Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Substances that are recognized by the immune system and induce an immune reaction.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*44 allele family.
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Substances elaborated by bacteria that have antigenic activity.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Substances elaborated by viruses that have antigenic activity.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*08 allele family.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*37 allele family.
A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.
An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Sites on an antigen that interact with specific antibodies.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*35 allele family.
Substances of fungal origin that have antigenic activity.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
The immovable joint formed by the lateral surfaces of the SACRUM and ILIUM.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
The major group of transplantation antigens in the mouse.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*07 allele family.
Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).
Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
A technique to study CELL MIGRATION in the INFLAMMATION process or during immune reactions. After an area on the skin is abraded, the movement of cells in the area is followed via microscopic observation of the exudate through a coverslip or tissue culture chamber placed over the area.
Antibodies produced by a single clone of cells.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*51 allele family.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Persons who have experienced prolonged survival of HIV infection. This includes the full spectrum of untreated, HIV-infected long-term asymptomatics to those with AIDS who have survived due to successful treatment.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Established cell cultures that have the potential to propagate indefinitely.
T-cell receptors composed of CD3-associated alpha and beta polypeptide chains and expressed primarily in CD4+ or CD8+ T-cells. Unlike immunoglobulins, the alpha-beta T-cell receptors recognize antigens only when presented in association with major histocompatibility (MHC) molecules.
Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.
Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.
Transmembrane proteins that form the beta subunits of the HLA-DQ antigens.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.
An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A species of the genus YERSINIA, isolated from both man and animal. It is a frequent cause of bacterial gastroenteritis in children.
Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and in the I region in mice.
Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (LAV) antigens.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*01 allele family.
A melanosome-specific protein that plays a role in the expression, stability, trafficking, and processing of GP100 MELANOMA ANTIGEN, which is critical to the formation of Stage II MELANOSOMES. The protein is used as an antigen marker for MELANOMA cells.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
A subspecialty of internal medicine concerned with the study of inflammatory or degenerative processes and metabolic derangement of connective tissue structures which pertain to a variety of musculoskeletal disorders, such as arthritis.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man.
Antigens stimulating the formation of, or combining with heterophile antibodies. They are cross-reacting antigens found in phylogenetically unrelated species.
Differentiation antigens expressed on B-lymphocytes and B-cell precursors. They are involved in regulation of B-cell proliferation.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion.
An encapsulated lymphatic organ through which venous blood filters.
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Infections with bacteria of the genus SALMONELLA.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
DNA probes specific for the human leukocyte antigen genes, which represent the major histocompatibility determinants in humans. The four known loci are designated as A, B, C, and D. Specific antigens are identified by a locus notation and number, e.g., HLA-A11. The inheritance of certain HLA alleles is associated with increased risk for certain diseases (e.g., insulin-dependent diabetes mellitus).
Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.
Proteins conjugated with nucleic acids.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
The sum of the weight of all the atoms in a molecule.
A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. Originally identified in the mouse, they are also found in other species including humans, and are expressed on brain neurons and other cells.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
A glycolipid, cross-species antigen that induces production of antisheep hemolysin. It is present on the tissue cells of many species but absent in humans. It is found in many infectious agents.
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Time period from 2001 through 2100 of the common era.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*03 allele family.
An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.
A bacterium which is one of the etiologic agents of bacillary dysentery (DYSENTERY, BACILLARY) and sometimes of infantile gastroenteritis.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*24 allele family.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Proteins prepared by recombinant DNA technology.
A broad specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*01:15 and DRB1*01:16 alleles.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A melanosome-associated protein that plays a role in the maturation of the MELANOSOME.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
A HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*07 alleles.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.
Diagnostic procedures involving immunoglobulin reactions.
Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the H-Y antigen.
A component of the B-cell antigen receptor that is involved in B-cell antigen receptor heavy chain transport to the PLASMA MEMBRANE. It is expressed almost exclusively in B-LYMPHOCYTES and serves as a useful marker for B-cell NEOPLASMS.
A broad-specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*11 and DRB1*12 alleles.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
Sialylated Lewis blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic hepatitis B, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins G.
Immunoglobulins produced in a response to HELMINTH ANTIGENS.
Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.
The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitized lymphocyte, an antibody, or complement.
Class I human histocompatibility (HLA) surface antigens encoded by alleles on locus B of the HLA complex. The HLA-G antigens are considered non-classical class I antigens due to their distinct tissue distribution which differs from HLA-A; HLA-B; and HLA-C antigens. Note that several isoforms of HLA-G antigens result from alternative splicing of messenger RNAs produced from the HLA-G*01 allele.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.
Antigens which may directly stimulate B lymphocytes without the cooperation of T lymphocytes.
Glycoprotein members of the immunoglobulin superfamily which participate in T-cell adhesion and activation. They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex.
Glycoproteins found on the membrane or surface of cells.
Transmembrane proteins that form the alpha subunits of the HLA-DQ antigens.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Adherent debris produced when cutting the enamel or dentin in cavity preparation. It is about 1 micron thick and its composition reflects the underlying dentin, although different quantities and qualities of smear layer can be produced by the various instrumentation techniques. Its function is presumed to be protective, as it lowers dentin permeability. However, it masks the underlying dentin and interferes with attempts to bond dental material to the dentin.
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
Carbohydrate antigen most commonly seen in tumors of the ovary and occasionally seen in breast, kidney, and gastrointestinal tract tumors and normal tissue. CA 125 is clearly tumor-associated but not tumor-specific.
Immunologically detectable substances found in the CELL NUCLEUS.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
An HLA-DR antigen associated with HLA-DRB1 CHAINS that are encoded by DRB1*01 alleles.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Elements of limited time intervals, contributing to particular results or situations.
Subunits of the antigenic determinant that are most easily recognized by the immune system and thus most influence the specificity of the induced antibody.
Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.
HLA-DR antigen subtypes that have been classified according to their affinity to specific ANTIBODIES. The DNA sequence analyses of HLA-DR ALPHA-CHAINS and HLA-DR BETA-CHAINS has for the most part revealed the specific alleles that are responsible for each serological subtype.
Antigens produced by various strains of HEPATITIS D VIRUS.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Glycoproteins with a wide distribution on hematopoietic and non-hematopoietic cells and strongly expressed on macrophages. CD58 mediates cell adhesion by binding to CD2; (ANTIGENS, CD2); and this enhances antigen-specific T-cell activation.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
A major histocompatibily complex class I-like protein that plays a unique role in the presentation of lipid ANTIGENS to NATURAL KILLER T-CELLS.

Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response. (1/17)

In an attempt to transduce monocyte-derived dendritic cells (DCs) with a retroviral vector coding for an intracytoplasmic tumor antigen (TAA), we were confronted by the evident dissociation between the ability of the treated DCs to induce a TAA-specific response, and the presence of integrated vector proviral DNA. The TAA, i.e., MAGE-3, was acquired by DCs and presented to immune effectors, thanks to the property of DCs to uptake the apoptotic bodies released by the irradiated vector-producing cells. Indeed, we observed that upon irradiation vector-producing cells underwent apoptotic cell death, monitored by annexin V and propidium iodide staining, and were phagocytosed by DCs. Lymphocytes obtained from a patient affected by a MAGE-3(+) melanoma, were stimulated in vitro with autologous DCs previously exposed to irradiated MAGE-3-expressing cells. This procedure led to the induction of MAGE-3-specific cytotoxic effectors, directed against a yet unknown MAGE-3 epitope presented by HLA-A*B5201 molecules. These data demonstrate that DCs can present engulfed human TAAs, thus providing strategies for cancer vaccination.  (+info)

Association of cytomegalovirus interstitial pneumonitis with HLA-type following allogeneic bone marrow transplantation. (2/17)

Certain human leukocyte antigens may increase the risk of cytomegalovirus interstitial pneumonitis, an important complication of bone marrow transplantation. The prevalence of this pneumonitis was compared between patients possessing either HLA-B51 or HLA-B52 and patients without either antigen. The role of tumor necrosis factor-alpha in cytomegalovirus interstitial pneumonitis was also studied. Among 72 patients undergoing allogeneic bone marrow transplantation at our institution during the past 5 years, HLA-B51 or -B52 was detected in 29. Among these 29 patients, 13 (45%) developed cytomegalovirus interstitial pneumonitis, a significantly higher rate (P < 0.001) than among patients without these HLA types (4/43, 9%). In the pre-conditioning and stable phases, tumor necrosis factor-alpha levels were higher in patients with HLA-B51 or HLA-B52 than in patients without (P < 0.05; t-test). Throughout the period from pre-conditioning to around day 40, except on day 0, tumor necrosis factor-alpha levels were also significantly higher (P < 0.05 to P < 0.001) in patients developing cytomegalovirus infection than in those without it. These results suggest that HLA-B51 and HLA-B52 may be risk factors for cytomegalovirus interstitial pneumonitis after bone marrow transplantation, with an increase of tumor necrosis factor-alpha also being involved.  (+info)

Identification of a 40S ribosomal protein S4-derived H-Y epitope able to elicit a lymphoblast-specific cytotoxic T lymphocyte response. (3/17)

PURPOSE: The superior graft-versus-leukemia (GVL) effect of the female-to-male stem cell transplantation is partially independent from the concomitant graft-versus-host reactivity. However, the antigenic basis of this selective GVL response remains enigmatic, because no H-Y antigens with hematopoietic-restricted expression were identified. In this study, we report a novel H-Y epitope that is preferentially recognized on activated proliferating lymphocytes. EXPERIMENTAL DESIGN: We generated a CTL clone YKIII.8 that showed reactivity toward male B*5201+ CD40-activated B cells, EBV-lymphoblastoid cell lines, and phytohemagglutinin-activated T-cell blasts but little or no reactivity toward fibroblasts, CD14+ cells, or unstimulated B and T cells. The antigen recognized by YKIII.8 was identified by screening of a cDNA expression library, and its pattern of expression was investigated. RESULTS: cDNA of the male isoform of 40S ribosomal protein S4 was found to encode the antigenic peptide TIRYPDPVI, which was recognized by YKIII.8. Western blot analysis showed that rapidly proliferating cells overexpress the RPS4 protein in comparison with nonrecognized cell subsets. Retroviral transfer of YKIII.8 T-cell receptor resulted in preservation of the lymphoblast-specific reactivity pattern. CONCLUSION: Our findings suggest that CTL specific to certain epitopes of ubiquitously expressed H-Y antigens may specifically target lymphoblasts, contributing to the selective GVL effect of female-to-male stem cell transplantation.  (+info)

Gender differences in chronic thromboembolic pulmonary hypertension in Japan. (4/17)

BACKGROUND: The predominance of chronic thromboembolic pulmonary hypertension (CTEPH) in females and association of HLA-B*5201 with CTEPH have been reported in Japan. However, the clinical characteristics of female CTEPH remain uncertain. The purpose of the present study is to clarify the clinical phenotype of female CTEPH in Japan. METHODS AND RESULTS: The 150 consecutive patients (female 103, male 47; age 52.8+/-12.4 years SD) were admitted to Chiba University Hospital, and diagnosis was confirmed using right cardiac catheterization and pulmonary angiography. Among these patients, 78 underwent pulmonary endarterectomy. Clinical characteristics, pulmonary hemodynamics, extent of central disease and surgical outcome in females were compared with those in males. The female patients were elderly and had less deep vein thrombosis, less acute embolic episodes, better cardiac function, lower arterial oxygen tension and more peripheral thrombi, and showed less improvement through surgery than males. When the patients were identified using HLA-B*5201, HLA-B*5201-positive female patients had less embolic episodes and better cardiac function with lower operative mortality. In contrast, HLA-B*5201-negative female patients had less embolic episodes, and more peripheral thrombi, resulting in less improvement by surgery. CONCLUSION: The clinical phenotype of female CTEPH differed from that of male CTEPH. Additionally, gender differences of HLA-B*5201-positive type were dissimilar to those of HLA-B*5201-negative type.  (+info)

Transfusion-related acute lung injury (TRALI) induced by donor-derived anti-HLA antibodies in aplastic anemia: possible priming effect of granulocyte-colony stimulating factor (G-CSF) on the recipient neutrophils. (5/17)

Transfusion-related acute lung injury (TRALI) is currently the leading cause of transfusion-related death. A 67-year-old man with severe aplastic anemia developed TRALI, consisting of acute respiratory insufficiency with severe hypoxia and diffuse pulmonary infiltration 2 hours after the transfusion of platelet concentrates. Although he required intensive respiratory support, he promptly recovered within 4 days. The presence of anti-HLA antibody (anti-HLA B52) in the donated blood product was demonstrated, and a lymphocytotoxicity test disclosed antibody-mediated cytotoxicity against the patient's cells. Furthermore, administration of granulocyte-colony stimulating factor was suggested to predispose the patient to TRALI by priming the neutrophils.  (+info)

Close association of HLA-B51 and B52 in Israeli patients with Behcet's syndrome. (6/17)

Epidemiological data, family history, clinical data, and HLA typing were studied in three groups of patients with Behcet's syndrome: six Israeli Ashkenazi Jews, 29 non-Ashkenazi Jews, and three Israeli Arabs. HLA-B51 and B52 were present in 24/38 (63%) and 8/38 (21%), respectively, of the patients compared with 13/151 (9%) of the control group for both cases, a relative risk of 18.2 and 2.8 respectively. The syndrome was found in six of the 34 families. Ninety five per cent of the affected family members were either B51 or B52 positive. Eleven of the 14 families (79%) chosen for study contained a close relative of the proband who had recurrent oral ulcers. All the relatives with ulcers, except for one, were B51 or B52 carriers. Recurrent oral ulcers in the patients with Behcet's syndrome began a few years before other manifestations of the syndrome occurred. Our findings suggest that (a) HLA-B51 and HLA-B52 are primarily associated with Behcet's disease of Israeli patients; (b) the familial occurrence of this syndrome is high and occurs predominantly in the B5 positive group; (c) recurrent oral ulcers may be the first symptom of Behcet's syndrome, appearing early in life; HLA analysis can provide the clue for a correct diagnosis; (d) ulcer recurrence is common among members of a family containing a patient with Behcet's syndrome.  (+info)

A case of Takayasu's arteritis associated with human leukocyte antigen A24 and B52 following resolution of ulcerative colitis and subacute thyroiditis. (7/17)

A 46-year-old female with a past history of ulcerative colitis (UC) was diagnosed with subacute thyroiditis (SAT), which improved with prednisolone (PSL) treatment (60 mg/day). The dose of PSL was gradually decreased, however upper back and neck pain and chest discomfort developed. The patient was diagnosed with Takayasu's arteritis (TA) based on wall thickening and luminal narrowing of the left common carotid artery and the left subclavian artery. The result of human leukocyte antigen typing analysis was A24 and B52 positive. These findings suggested that common genetic factors may be important for the etiology of TA, UC and SAT. This is the first report of TA that developed following UC and SAT.  (+info)

Association between Takayasu arteritis and ulcerative colitis - case report and review of serological HLA analysis. (8/17)

BACKGROUND: Takayasu arteritis and ulcerative colitis are immune-mediated inflammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported. CASE REPORT: In this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Takayasu arteritis. He was found to carry the following human leukocyte antigens (HLA): A11, A24, B52, B62, DR4, and DR9. CONCLUSIONS: We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases. In patients with both Takayasu arteritis and ulcerative colitis, high frequency of HLA-A24, B52, and DR 2 is observed. The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.  (+info)

The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Tumor Necrosis Factor Beta (TNFb) were tested on 3 different plates, 8 replicates in each ...
This antibody neutralizes TNF alpha biological activities. It prevents TNF alpha induced apoptosis in Jurkat cells. It also neutralizes HurTNFamediated cytotoxicity of L929 cells and inhibits tumor growth in mice. It protects mice against toxicity of HurTNFa. Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal ...
MSD offers a range of individual assays utilizing U-PLEX Antibody Sets that provide a rapid and convenient method for measuring biomarkers in complex matrices. The individual assays are offered on MSD GOLD Small Spot Streptavidin Plates and use the same antibody sets and diluents as the U-PLEX multiplex assays. This allows for efficient transfer between the individual assay and a higher throughput multiplex configuration. Typical of assays developed on the MSD platform, the individual assays have high sensitivity, excellent precision, provide up to five-logs of linear dynamic range, and require minimal sample volume. Tumor necrosis factor beta (TNF-β), also known as lymphotoxin-alpha (LT-alpha) and TNFSF1, is a glycosylated 22.3 kDa protein. It is produced by lymphocytes, and in its homotrimeric form, it binds to TNFR1, TNFRII, and TNFRSF14. In its heterotrimeric form with lymphotoxin-beta, it binds to TNFRSF3. It is cytotoxic for a wide range of tumor cells. A polymorphism of the TNF-β gene ...
Human tumor necrosis factor beta (TNF-β), also known as lymphotoxin-alpha (LT-alpha) and TNFSF1, is a glycosylated 22.3 kDa protein. It is produced by lymphocytes, and in its homotrimeric form, it binds to TNFR1, TNFRII, and TNFRSF14. In its heterotrimeric form with lymphotoxin-beta, it binds to TNFRSF3. It is cytotoxic for a wide range of tumor cells. A polymorphism of the TNF-β gene is identified as a major risk factor for early-onset leprosy. The Human TNF-β Kit provides assay-specific components for the quantitative determination of endogenous TNF-β in human urine, serum, plasma, and cell culture supernatants. ...
Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them.[1] It is also known to be required for normal development of Peyers patches.[2] Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs. ...
The clinical characteristics of Takayasu arteritis (TAK) developing in individuals older than 40 years (TAK |40) are little-known. We retrospectively analyzed 43 patients with TAK treated at three hospitals in Japan from April 2000 to March 2016. From medical records we collected baseline variables at diagnosis including clinical symptoms, laboratory data, and subsequent relapses. We compared these indices in the patients with TAK onset at |40 years of age (TAK |40) to those with TAK onset ≤40 years (TAK ≤40). Multiplex cytokine/chemokine bead assays were performed using preserved serum supernatants from 24 patients with TAK and 40 healthy donors. Of the 43 patients, 20 had TAK |40; this group had significantly fewer instances of orthostatic hypotension (2 (10%) vs. 10 (43%), p = 0.019), carotid bruit (7 (35%) vs. 16 (70%), p = 0.034), and chest pain (0 (0%) vs. 6 (26%), p = 0.023) compared to patients with TAK ≤40 (n = 23). The initial prednisolone dose was significantly lower in TAK |40 (median
Takayasu arteritis is a chronic inflammatory disease of the aorta and its major branches. The disorder is a large vessel vasculitis of unknown origin that most often affects young women in the second and third decades of life (see the image below).
Citation: Aydın F, Acar B, Uncu N, Başaran Ö, Adalet Yıldız E, Güven A, et al. Takayasu Arteritis: A Case Presenting With Neurological Symptoms and Proteinuria. Arch Rheumatol 2020;35(2):287-291. ...
ENFERMEDAD DE TAKAYASU PEDIATRIA PDF - PDF | Takayasu arteritis is an idiopathic granulomatous vasculitis of the Service of Immunology & Rheumatology, Hospital de Pediatría
Statistiche di Mappa - Arterite di Takayasu - Controlla come questa condizione influisce sulla vita quotidiana delle persone che ne soffrono.
The chromatographic behaviour of recombinant human tumour necrosis factor beta (rhTNF-β) (pI ~9.0) during cation-exchange chromatography at pH 7.5 is investigated. Without prior treatment of the Escherichia coli cell extract with polyethyleneimine (PEI), very little rhTNF-β was bound to the column. However, upon addition of 5% PEI (100 μl ml-1) to the cell lysate, rhTNF-β was shown to bind to cation-exchange columns normally. TNF-β was readily precipitated from the clarified cell extract by 20% ammonium sulphate, but only ca. 25% of this precipitate could be re-solubilized for further purification. However, when 5% PEI was included in the solubilization buffer, the balance of the rhTNF-β could be recovered. It is proposed that charge interaction between rhTNF-β and nucleic acids in the cell extract is responsible for both of these anomalous phenomena, and that PEI (a cationic polyelectrolyte) was able to disrupt this interaction by displacing rhTNF-β from the charge complex ...
On average it takes 44 months from onset of symptoms to diagnose Takayasu arteritis. Because of its rarity and the often subtle physical findings, Takayasu arteritis frequently fails to enter the differential diagnosis for patients with fever of unknown origin (FUO). Thus it is critical to consider Takayasu arteritis in patients under 40 with FUO, aortic regurgitation, hypertension, or absent pulses. Rarely, patients older than 40 years of age meet the criteria for Takayasu arteritis because of a prolonged pre-diagnostic period or late onset of symptoms. In this case, giant cell arteritis may be indistinguishable from Takayasu arteritis; however, initial treatment for both is nearly identical ...
TY - JOUR. T1 - Subclavian steal syndrome secondary to Takayasu Arteritis in a young female Caucasian patient. AU - Tsivgoulis, Georgios. AU - Heliopoulos, Ioannis. AU - Vadikolias, Konstantinos. AU - Birbilis, Theodosios. AU - Piperidou, Charitomeni. PY - 2010/9/15. Y1 - 2010/9/15. N2 - Subclavian steal syndrome (SSS) is most frequently described in Caucasians aged over 50 years because of increased incidence of atherosclerosis in this population. Non-atherosclerotic etiologies of SSS are rare in Caucasians. We present a case of Subclavian Steal Syndrome secondary to Takayasu Arteritis (TA) in a 26 year-old female Caucasian patient. The present case underscores that despite the very low incidence of TA in Caucasians (0.8/1,000,000), this large-vessel vasculitis of unknown etiology should always be considered in the differential diagnosis of subclavian steal syndrome in Caucasian women aged less than 40 years.. AB - Subclavian steal syndrome (SSS) is most frequently described in Caucasians aged ...
Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare, but fatal complication of blood transfusions. TA-GVHD occurs when donor lymphocytes, not recognized as foreign antigen, mount an immune response against the recipients tissue. While host immune defects, component characteristics and donor-recipient HLA relationships have all been identified as factors associated with TA-GVHD, the relative importance of each […]. [Read More] ...
RefSeq Summary (NM_021160): A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010 ...
Vessel imaging in Takayasu arteritis (TAK) is often performed in clinical practice following laboratory test abnormalities or clinical symptoms, such as limb claudication. Conversely, the association between limb claudication and vessel imaging manifestations has not been assessed. This observational, cross-sectional study analyzed 139 adult TAK patients from 2000 to 2018. Their arterial vessel imaging information (especially significant stenosis and occlusion data) was registered and crosschecked with clinical and laboratory data. When vessel imaging was performed, the median age and disease duration of the patients were 38 (27.3-47.0) and 5.0 (1.0-12.0) years, respectively. There was no association between arterial abnormalities and demographic data, constitutional symptoms or laboratory parameters. Limb claudication was reported in 42 patients (30.2%): 17.3% reported it in the upper left limb (ULL), 12.2% reported it in the upper right limb (URL), 12.9% reported it in the lower left limb ...
Rosenberg IL, Jarjour WN. Rosenberg I.L., Jarjour W.N. Rosenberg, Irving L., and Wael N. Jarjour.GIANT CELL AND TAKAYASU ARTERITIS. In: Dean SM, Satiani B, Abraham WT. Dean S.M., Satiani B, Abraham W.T. Eds. Steven M. Dean, et al.eds. Color Atlas and Synopsis of Vascular Diseases New York, NY: McGraw-Hill; 2014. http://accesscardiology.mhmedical.com/content.aspx?bookid=1201§ionid=71015746. Accessed February 23, 2018 ...
This study is the first double-blind, randomised controlled trial of anti-cytokine therapy for the treatment of patients with TAK. It was designed to investigate whether tocilizumab treatment enables GC tapering. Investigating the efficacy of therapeutic agents in TAK is challenging because no efficacy endpoint has been validated. Kerrs definition of active disease3 has been used in case reports and cohort studies,11 16 21 23 28-30 but the requirement for imaging studies such as CT, MRI and/or positron emission tomography places a greater burden on patients in terms of exposure and risk from contrast dyes, and it may not be possible to perform imaging for every suspected relapse. Therefore, this study adopted a definition of relapse that was based on the signs and symptoms of TAK without imaging evaluations.. The current study was designed to evaluate time to relapse of TAK with mandatory GC tapering. To induce remission, patients who experienced relapse received GCs at a dose at least twice ...
Learn about Takayasu disease, a chronic inflammation of the aorta. Takayasu disease symptoms include dizziness, headaches, chest pain, and abdominal pain.
16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, 30S ribosomal protein S5, 30S ribosomal protein S6, 30S ribosomal protein S7, 30S ribosomal protein S8, 30S ribosomal protein S9, 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, 30S ribosomal protein S13, 30S ribosomal protein S14, 30S ribosomal protein S15, 30S ribosomal protein S16, 30S ribosomal protein S17, 30S ribosomal protein S18, 30S ribosomal protein S19, 30S ribosomal protein S20, 30S ribosomal protein Thx, RNA (5-R(*AP*AP*AP*AP*AP*GP*GP*AP*AP*AP*UP*A*AP*AP*AP*AP*UP*GP*CP*AP*GP*UP*UP*CP*AP*AP*UP*CP*UP*A)-3), tRNA-Gln, tRNA-Met, tRNA-Gln, capreomycin IA, 50S ribosomal protein L27, 50S ribosomal protein L28, 50S ribosomal protein L29, 50S ribosomal protein L30, 50S ribosomal protein L31, 50S ribosomal protein L32, 50S ribosomal protein L33, 50S ribosomal protein L34, 50S ribosomal protein L35, 50S ribosomal protein L36, 23S ribosomal RNA, 5S ribosomal RNA, ...
TY - JOUR. T1 - The acute diagnosis of takayasus arteritis based on helical CT angiography of the chest and neck in the emergency room. AU - Pinheiro, Lisa Winer. AU - LeBlang, Suzanne D.. AU - Romano, Jose. AU - Forteza, Alex. PY - 1999/11/30. Y1 - 1999/11/30. N2 - Recently, a young woman presented acutely with a left hemispheric stroke and differing blood pressures in the arms as her initial manifestation of Takayasus arteritis. Helical CT angiography, performed to rule out aortic dissection, revealed a thickened wall of the aortic arch with stenoses and occlusions of the great vessels, suggesting the diagnosis. The sequence of imaging studies and findings in this unusually catastrophic presentation of a typically insidious disease are highlighted.. AB - Recently, a young woman presented acutely with a left hemispheric stroke and differing blood pressures in the arms as her initial manifestation of Takayasus arteritis. Helical CT angiography, performed to rule out aortic dissection, ...
Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of blood transfusion, in which the donor T lymphocytes mount an immune response against the recipients lymphoid tissue. Donor lymphocytes are usually identified as foreign and destroyed by the recipients immune system. However, in situations where the recipient is immunocompromised (inborn immunodeficiency, acquired immunodeficiency, malignancy), or when the donor is homozygous and the recipient is heterozygous for an HLA haplotype (as can occur in directed donations from first-degree relatives), the recipients immune system is not able to destroy the donor lymphocytes. This can result in graft-versus-host disease. The incidence of TA-GvHD in immunocompromised patients receiving blood transfusions is estimated to be 0.1 - 1.0%, and mortality around 80 - 90%. Mortality is higher in TA-GvHD than in GvHD associated with bone marrow transplantation, where the engrafted lymphoid cells in the bone marrow are of donor ...
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A man aged 20 with sudden onset of headaches and rapidly evolving spastic quadriparesis died within 3 weeks. Pathologic examination revealed intensive inflammation confined mainly to the adventitia of the aorta, the internal carotids, and all the major intracranial arteries. The gross changes and the lymphocytic and plasma cell nature of the inflammatory infiltrates were typical of Takayasus arteritis. Thrombosis of the right internal carotid artery resulted in ischemic necrosis of the ipsilateral hemisphere. Quite recent thrombus occluded the left internal carotid artery. This seems to be the first case report on histologically proven extensive direct involvement of intracranial vessels in Takayasus disease. The differential diagnostic aspects of the case are also briefly discussed. ...
Define Takayasu. Takayasu synonyms, Takayasu pronunciation, Takayasu translation, English dictionary definition of Takayasu. Noun 1. Takayasus arteritis - disorder characterized by the absence of a pulse in both arms and in the carotid arteries pulseless disease arteritis -...
A 9-year-old girl presented with cervical mass 2 months before heart failure. Her grandfather had died of tuberculosis 6 years previously. Tuberculous lymphadenitis was proved by biopsy of a neck mass, and chest radiography revealed no pulmonary tuberculosis or cardiomegaly (A). She developed heart failure and cardiomegaly (B) 1 month after the initiation of an antituberculosis regimen.. Echocardiography revealed a dilated left atrium and left ventricle with decreased left ventricular ejection fraction (35%). Computed tomography showed severe discrete stenosis in the thoracic aorta, with the narrowest diameter measured as 3 mm (C, D). The diagnosis of Takayasu arteritis was established because the patient had evident angiographic abnormalities, high blood pressure at the bilateral upper extremities (150/96 mm Hg), an undetectable pulse at the bilateral lower extremities, and bruit over the aorta (1-3). Methylprednisolone was administered for 4 weeks, but heart failure and aortic stenosis did not ...
casSAR Dugability of A4FWE8 | rps10 | 30S ribosomal protein S10 - Also known as RS10_METM5, rps10. Involved in the binding of tRNA to the ribosomes. Part of the 30S ribosomal subunit.
Recombinant Human 40S ribosomal protein S18 Protein. Synthesized in e. coli. Protein Tag: GST. Purity: Greater than 90% as determined by SDS-PAGE. From $88
casSAR Dugability of A6U858 | rpsJ | 30S ribosomal protein S10 - Also known as RS10_SINMW, rpsJ. Involved in the binding of tRNA to the ribosomes. Part of the 30S ribosomal subunit.
casSAR Dugability of Q03UD8 | rpsF | 30S ribosomal protein S6 - Also known as RS6_LACBA, rpsF. Binds together with S18 to 16S ribosomal RNA.
BACKGROUND: The present paper reports the preliminary experience with surgical treatment of 49 cases of cerebral ischaemia caused by cervical arterial lesions due to Takayasus arteritis (TA). METHODS: Six men and 43 women were treated between June 1
We used FDG-PET/CT to assess TA disease activity, because this modality can identify sites of accelerated metabolism indicative of an inflammatory reaction, and max SUV can be used to quantitatively represent the degree of inflammation. Our present results thus support the concept that max SUV provides a valid means of comparing patients with active and inactive TA. We examined whether changes in blood glucose levels and venous mean SUV would impact the validity of our arterial max SUV data but found that these data did not differ between active and inactive TA.. Webb et al. (5) were the first to report the diagnostic accuracy of FDG-PET in 18 TA cases. Their SE was 92%, and SP was 100%. Disease activity was determined by a combination of clinical symptoms of TA in this report. Kobayashi et al. (10) were the first to establish a cutoff for max SUV in their study of 14 TA patients. Their SE was 90.9%, and SP was 88.8%, but they defined active disease as a clinical requirement for prednisolone. ...
Takayasu Arteritis is a vasculitis occurring mostly in young females which may present in diverse ways. Here we report a teenager with Takayasu Arteritis who presented with uncontrolled hypertension. This case depicts an atypical presentation of this
Results A total of 184 patients with TA were identified. The mean age at diagnosis was 35.3±16.4 years and 160 (87.2%) were female. Forty-four (23.9%) patients underwent open surgery and 25 (13.6%) patients underwent a percutaneous endovascular intervention. After median follow-up of 20.1±1.4 years, 17 (38.6%) patients in the open surgery group and 11 (44%) patients in the percutaneous intervention group developed significant restenosis requiring a second intervention (Fig. 1). The use of corticosteroid, azathioprine or cyclophosphamide did not affect restenosis rate (HR=0.77, 95% CI: 0.3-2.0). Nor did disease activity or traditional cardiovascular risk factors such as diabetes and hypertension (P,0.05). However, use of methotrexate was associated with a higher risk of significant restenosis (HR=2.48, 95% CI 1.074-5.747).. ...
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TY - JOUR. T1 - Controversial findings in three-Dimensional Vvelocity Mapping of Thoracic Aorta and Supra-aortic Arteries in Takayasu Arteritis. AU - Frydrychowicz, Alex. AU - Landgraf, Ben. AU - Markl, Michael. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/1. Y1 - 2011/1. UR - http://www.scopus.com/inward/record.url?scp=78650668893&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=78650668893&partnerID=8YFLogxK. U2 - 10.1002/jmri.22403. DO - 10.1002/jmri.22403. M3 - Letter. C2 - 21182148. AN - SCOPUS:78650668893. VL - 33. SP - 252. EP - 253. JO - Journal of Magnetic Resonance Imaging. JF - Journal of Magnetic Resonance Imaging. SN - 1053-1807. IS - 1. ER - ...
In LANCE Ultra kinase assays, the binding of a Eu-labeled anti-phosphosubstrate antibody to the phosphorylated ULight-labeled substrate brings donor and acceptor molecules into close proximity. After irradiation of the kinase reaction at 320 or 340 nm, the energy from the Eu donor is transferred to the ULight acceptor dye, which in turn generates light at 665 nm. The intensity of the light emission is proportional to the level of ULight-substrate phosphorylation.. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Full Papers; Authors: C. Arslan>, C. Tel>, B. Arapi>, S. Esatoglu>, K. Besirli>, A. Bozkurt>, V. Hamuryudan>, H. Tuzun>, E. Seyahi>
Takayasus arteritis is a chronic systemic inflammatory disease that usually affects the aorta, its primary branches and occasionally the pulmonary and coronary arteries. Female gender in reproductive age and Asian origin are known factors associated with higher disease prevalence. The clinical manifestations vary considerably and are typically caused by limb or organ ischemia illness and fever. The estimated incidence rate in the western world is 2.6 cases per million persons per year. Occasionally, exertional dyspnea can be the sole primary clinical manifestation of Takayasus arteritis. We report the case of a 57-year-old woman who was referred to our institution with increasing exertional dyspnea caused by pulmonary artery involvement in Takayasus arteritis. In a review of the literature we discuss demographic data, clinical and radiographic findings and available therapeutic options. Dyspnea due to pulmonary artery involvement can be the initial symptom of Takayasus arteritis. Simple clinical
Takayasu arteritis (TA) is a chronic large vessel vasculitis that affects aorta, its main branches and pulmonary arteries. The inflammatory process results in stenosis, occlusion, dilation or aneurysm formation in the arterial wall.. Continue reading Criteria for the Classification of Takayasu Arteritis. ...
Figure 2 The American Journal of Human Genetics , DOI: ( /j.ajhg ) Copyright © 2013 The American Society of Human Genetics Terms and Conditions Terms and Conditions
Takayasu arteritis is a granulomatous panarteritis that predominantly affects the aorta and its major branches. The initial manifestations of this large-vessel vasculitis are usually nonspecific; however, as the disease progresses, typical symptoms of arterial occlusion, aneurysmal formation, and vascular pain become evident. Ischemic ocular complications of Takayasu arteritis which could lead to complete loss of vision are not uncommon and depend on the obliterated portion(s) of carotid(s), the intensity and rate of progression of ocular vascular insufficiency, and sufficiency of the collateral blood supply to the eye. A 24-year-old woman of African descent with prior normal vision was referred to us with a 3-year history of gradual decline in visual acuity in both eyes and unintentional weight loss (17 kg) within the past 1 year. A physical examination revealed feeble brachial and radial arterial pulses on her left side. She had sinus tachycardia (136 beats/minute) and her blood pressure was 85/59
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008 ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
B51 is a split antigen of the broad antigen B5, and is a sister serotype of B52. There are many alleles within the B*51 allele ... HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products. ... Several alleles of B51 (B*5101, B*5108, B*5105, and B*5104) are found in disease, and linkage to markers, D6S285, in the HLA ...
... (B5) is an HLA-B serotype. B5 is a broad antigen serotype that recognizes the B51 and B52 split antigen serotypes. Marsh ... "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291-455. doi:10.1111/j.1399-0039.2010.01466.x. PMC ... Robinson J, Waller MJ, Fail SC, Marsh SG (2006). "The IMGT/HLA and IPD databases". Hum. Mutat. 27 (12): 1192-9. doi:10.1002/ ...
"HL-A antigens in congenital rubella and the role of antigens 1 and 8 in the epidemiology of natural rubella". Tissue Antigens. ... Italy A1-B52 Bharghavas-India, Tribal-India, Italy, Iberia, France A1-B57 (See tables on discussion page) A1-B58 (See tables on ... HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody ... antigens were first being described. The associations rapidly expanded to include 'HL-A8' HLA-B8, as the HLA A1 and B8 were ...
... (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products. B52 is a split antigen of ... HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan. This form of disease is frequently found with ... January 1989). "HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain". J. ... January 2003). "Cloning and sequencing full-length HLA-B and -C genes" (PDF). Tissue Antigens. 61 (1): 20-48. doi:10.1034/j. ...
... antigen groups, A23 & A24 and B51 & B52, respectively. As the HL-A serotyping developed, so did identification of new antigens ... Human leukocyte antigens (HLA) began as a list of antigens identified as a result of transplant rejection. The antigens were ... Classification and description of DP antigens is ongoing. The naming of human leukocyte antigens HLA "antigens" is deeply ... HLA-A or HLA-B) identifies which gene the allele is a modification of. The first two numbers (HLA-A*02) signifies what antigen ...
Serotypes of HLA-B gene products antigen. -. Broad. antigen. Split antigens B7. B5. B51. B52. ... HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA- ... HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system ... They are HLA-A, HLA-B, (both Class I MHCs) and HLA-DR (a Class II MHC).[5] If the two tissues have the same genes coding for ...
... (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the ... A*02:Cw*16 is associated with increased higher viral load in HIV A2-B7 (Node in Netherlands) A2-B5 A2-B51 A2-B52 A2-B8 A2-B13 ... Before this revision, HLA-A*02 was also referred to as HLA-A2, HLA-A02, and HLA-A*2. HLA-A*02 is one particular class I major ... Tissue Antigens. 11 (2): 96-112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067. "HLA Nomenclature @ hla.alleles.org". ...
Compound: HLA class I histocompatibility antigen, B-52 alpha chain. Species: Homo sapiens [TaxId:9606]. Gene: HLA-B. Database ... Compound: HLA class I histocompatibility antigen, B-52 alpha chain. Species: Homo sapiens [TaxId:9606]. Gene: HLA-B. Database ... Description: Crystal structure of HLA-B*5201 in complexed with HIV immunodominant epitope (TAFTIPSI). Class: immune system. ...
1995) Peptide motifs of HLA-B51, -B52 and -B72 molecules, and implications for Behcets disease. Int Immunol 7:223-228, pmid: ... On comparing the primary structure of HLA-G to HLA-A, -B, and -C sequences, a high homology for HLA-A2 can be found ((45)). ... 1996) Antigen-presenting function(s) of the non-classical HLA-E, -F and -G class I molecules: the beginning of a story. Res ... 1990) A class I antigen, HLA-G, expressed in human trophoblasts. Science (Wash DC) 248:220-223, pmid:2326636.. ...
For certain numbers of specificity e.g. HLA- A26, A29, B39, B52, B56, Cw5, Cw6 the percentage of sera, where the s-HLA ... For most of numbers of the allelic specificity the concentration of antigen material in soluble form (s-HLA-I) in blood serum ... Soluble HLA class I antigens in serum of healthy individuals-population study ... Authors point on usefulness of results for s-HLA comparative analysis of particular HLA allelic specificity, specific for ...
Close association of HLA-B52 and HLA-B44 antigens in Israeli Arab adolescents with recurrent aphthous stomatitis ... HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance?. Albanidou-Farmaki, E.; Deligiannidis, A.; Markopoulos ...
HLA*0207 and dengue 1, HLA*B52 and dengue 2).. Polymorphisms in the vitamin D receptor and Fc-gamma receptor genes may be ... Detection of NS1 antigen, IgM and IgG from oral swabs, and dengue RNA in urine are being evaluated and may prove useful, ... Certain HLA alleles appear to be protective (e.g. HLA DR alleles in Mexican and Vietnamese populations), whereas others are ... NS1 antigen test (by ELISA or lateral flow rapid test) - not currently available in the US. For primary infections, NS1 Ag test ...
Increased frequency of certain human leukocyte antigen (HLA) types as HLA-Cw7 [7] HLA-B51 [7, 8], HLA-B52, and HLA-B44 [9] was ... L. Jaber, A. Weinberger, T. Klein, I. Yaniv, and M. Mukamel, "Close association of HLA-B52 and HLA-B44 antigens in Israeli Arab ... A. Weinberger, "Human lymphocyte antigen (HLA) B51 is more frequent in patients with recurrent aphthous stomatitis (RAS)," ... Human milk contains many components (i.e., TGF-β and IL-10) that promote tolerance to the dietary and microflora antigens. In ...
HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products. B52 is a split antigen of ... HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan. This form of disease is frequently found with ... January 1989). "HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain". J. ... January 2003). "Cloning and sequencing full-length HLA-B and -C genes" (PDF). Tissue Antigens. 61 (1): 20-48. doi:10.1034/j. ...
HLA A30 (19) split antigen was not identified in immunized women while HLA A23 (9) split antigen was not identified in non ... The genotype frequencies of HLA A2, A3, A28, B13, B17, B35, B52, B60, Cw2, Cw6, DR4, and DQ3 were significantly increased, ... We have studied the incidence of HLA A, B, C, DR and DQ loci antigen in Rh (D) antigen isoimmunized mothers compared to those ... Role of HLA antigens in Rh (D) alloimmunized pregnant women from Mumbai, Maharashtra, India ...
HLA A2 polymer type = MHC Class I, A cell surface antigen image source = Rendering of PDB2,2git: α (A*0201 gene product), β2 ... HLA-B5 - (B5) is an HLA B serotype. B5 is a serotype that recognizes the B51 and B52 serotypes.cite journal , author = Marsh SG ... HLA-A9 - (A9) is a broad antigen HLA A serotype that recognized the HLA A23 and HLA A24 serotypescite journal , author = ... HLA-G - histocompatibility antigen, class I, G, also known as HLA G, or Human Leukocyte Antigen G, is a human gene. PBB Summary ...
Antigen of human leukocyte B52(5) Current Synonym true false 3435203019 HLA-B52(5) antigen Current Synonym true false ... Antigen of human leukocyte B52(5) (substance). Code System Preferred Concept Name. Antigen of human leukocyte B52(5) (substance ... Human leukocyte antigen class I type antigen A1 - B57 (substance) {259989002 , SNOMED-CT } ...
HLA Antigens Broad, Splits and Associated Antigens. The listing of broad specificities in parenthesis after a narrow ... B51, B52, B5102#, B5103#. B7. B703#. B12. B44, B45. B14. B64, B65. ... specificity, e.g. HLA-A23(9) is optional. The following is a list of those specificities which arose as clear-cut splits of ... other specificities and of associated antigens (#) which are variants of the original broad specificity and not splits as ...
Alloreactive cytolytic T cell clones with dual recognition of HLA-B27 and HLA-DR2 antigens: selective involvement of CD8 in ... Five of the HLA class I alleles analyzed in this study, B35, B51, B52, B53, and B78, are members of a serologically cross- ... The amino acid sequences of the α1 and α2 regions of HLA-B*3501, HLA-B*5101, HLA-B*5201, HLA-B*5301, HLA-B*7801, and HLA-B*0702 ... Peptide binding to HLA class I molecules. Peptide-binding affinity for HLA class I molecules was assessed by an HLA ...
class I MHC B52 p-Y1007-JAK2 class I MHC B37 GBP7 GBP5 p-Y440-IFNGR1 HLA class I histocompatibility antigen, A-30 alpha chain ... HLA class I histocompatibility antigen, A-33 alpha chain HLA class II histocompatibility antigen, DRB1-1 beta chain HLA class I ... HLA class I histocompatibility antigen, Cw-6 alpha chain precursor HLA class I histocompatibility antigen, A-80 alpha chain HLA ... HLA class II histocompatibility antigen, DRB1-10 beta chain HLA class II histocompatibility antigen, DRB1-8 beta chain HLA ...
HLA-B5 (B5) is an HLA-B serotype. B5 is a broad antigen serotype that recognizes the B51 and B52 split antigen serotypes. Marsh ... "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291-455. doi:10.1111/j.1399-0039.2010.01466.x. PMC ... Robinson J, Waller MJ, Fail SC, Marsh SG (2006). "The IMGT/HLA and IPD databases". Hum. Mutat. 27 (12): 1192-9. doi:10.1002/ ...
HLA - Human leukocyte antigen B52 Current Synonym true false 387337017 Human leukocyte antigen B52 Current Synonym true false ... Human leukocyte antigen class I type antigen A1 - B57 (substance) {259989002 , SNOMED-CT } ... Human leucocyte antigen B52 Current Synonym true false 387339019 HLA - Human leucocyte antigen B52 Current Synonym true false ... Human leukocyte antigen B52 (substance). Code System Preferred Concept Name. Human leukocyte antigen B52 (substance). ...
HLA-B52 Antigen 1 Citation (Scopus) Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice ...
The results suggest that immune responses mediated by class I HLA molecules are associated with susceptibility to CC. ... HLA-B52 Antigen / analysis Actions. * Search in PubMed * Search in MeSH * Add to Search ... An MHC fine-mapping study was conducted on CC risk in the Japanese population by applying a human leukocyte antigen (HLA) ... HLA amino acid positions associated with CC risk in HLA-B molecule are indicated in a 3-dimensional ribbon model. The protein ...
HLA-B52 Antigen / genetics* Actions. * Search in PubMed * Search in MeSH * Add to Search ... In the HLA association studies, HLA-A*11:01:01:01 [Pc = 0.013, OR = 2.26 (1.27-3.91)] and HLA-C*12:02:02:01-HLA-B*52:01:01:02 [ ... HLA haplotype distributions of HLA-A, HLA-B and HLA-C in sCOVID-19 patients. The height of each orange boxes represents the ... HLA haplotype distributions of HLA-A, HLA-B and HLA-C in sCOVID-19 patients. The height… ...
Combined analysis of HLA-antigen frequencies in patients with chronic periodontitis.. Tab 3: Combined analysis of HLA-antigen ... HLA-A23, -A24 and HLA-B51, -B52).. This meta-analysis shows evidence that aggressive periodontitis among Caucasians is ... Meta-analysis of all HLA antigen frequencies in chronic periodontitis revealed no positive associations, however HLA-A2 turned ... Cullinan MP, Sachs J, Wolf E, Seymour GJ: The distribution of HLA-A and -B antigens in patients and their families with ...
Jaber L, Weinberger A, Klein T, Yaniv I, Mukamel M. Close association of HLA-B52 and HLA-B44 antigens in Israeli Arab ... Correlation between histocompatibility antigens and recurrent aphthous stomatitis in the Brazilian population. Braz J ...
HLA-B51 differs in only two amino acids from HLA-B52, other split antigen of HLA-B5, which is not associated with Behçets ... For HLA-B51, all bound peptides fluctuated to larger extent than HLA-B52. Free energy profiles of unbinding process for ... Antígeno HLA-B51/metabolismo , Antígeno HLA-B52/metabolismo , Humanos , Simulação de Dinâmica Molecular , Peptídeos/metabolismo ... Genetic tendency has an important role in its pathogenesis, and HLA-B51, a class I MHC antigen, has been recognized as the ...
HLA class I histocompatibility antigen, B-52 alpha chain. Protein function. Involved in the presentation of foreign antigens to ... antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479];. antigen ... antigen processing and presentation of peptide antigen via MHC class I [GO:0002474];. interferon-gamma-mediated signaling ... peptide antigen binding [GO:0042605]. Gene Ontology. (Cellular Component). Complete annatation. cell surface [GO:0009986];. ...
Serotypes of HLA-B gene products antigen. -. Broad. antigen. Split antigens B7. B5. B51. B52. ... HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA- ... HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system ... They are HLA-A, HLA-B, (both Class I MHCs) and HLA-DR (a Class II MHC).[5] If the two tissues have the same genes coding for ...
... split antigen (plural split antigens) (biochemistry) In the testing of cell surface antigens, an antigen that has a more ... HLA-B51 and HLA-B52 are split antigens of HLA-B5) Cancel You agree with international-dictionary.com terms of use and privacy ... split antigen (plural split antigens) (biochemistry) In the testing of cell surface antigens, an antigen that has a more ... split antigen. See a mistake? Help us improve the quality of the definitions. Its fast and easy - simply click the edit icons ...
The HLA type was A24, A31, B7, B52, DR1, and DR15 in the donor and A31, A33, B7, B44, DR1, and DR12 in the recipient. A pre- ... and HLA class 1 and 2 antibodies were negative by LABScreen single antigen testing. Induction immunosuppressive therapy was ... HLA class 1 and 2 antibodies were negative during this period, and MICA019 antibody was higher before transplantation ... MICA was originally pointed out to be an HLA-related polymorphic gene, the product of which may be recognized by a ...
B51 is a split antigen of the broad antigen B5, and is a sister serotype of B52.[2] There are a large number of alleles within ... derived from IMGT/HLA *^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ... EBI-HLA B*5101 1e28​, 1e27​ HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products. ... Serotypes B51, B5, B52, and B53 recognition of some HLA B*51 allele-group gene products[3] B*51. B51 B5 B52 B53. Sample ...
1981) Behçets disease: lack of correlation of clinical manifestations with HLA antigens. Tissue Antigens 17:226-230PubMed ... 1995) Peptide motifs of HLA-B*51,-B52 and-B78 molecules, and implications for Behcets disease. Int Immunol 7:223-228PubMed ... 1999) HLA and tumour necrosis factor (TNF) polymorphisms in ocular Behcets disease. Tissue Antigens 54:264-272CrossRefPubMed ... Paul M, Klein T, Krause I, Molad Y, Narinsky R, Weinberger A (2001) Allelic distribution of HLA-B* 5 in HLA-B5-positive Israeli ...
The most and least frequent HLA-B antigens were B5 group [B51/B52] and B16 [38,39] respectively. Because of low resolution of ... In this study our aim was to determine HLA-Class I and II antigens freguencies of Hamedani ethnic group. In addition to ... HLA-Class I and II frequencies in ethnic Hamedani people, and the comparison of serological and molecular [PCR] methods for HLA ... In addition, typing of Rh and Kell antigens in some regular blood donors could be helpdul for selecting antigen-negative RBCs ...
  • There are 18 alleles, with 14 amino acid sequence variants in B52. (wikipedia.org)
  • Certain HLA alleles appear to be protective (e.g. (renalandurologynews.com)
  • HLA DR alleles in Mexican and Vietnamese populations), whereas others are associated with greater susceptibility to disease (eg. (renalandurologynews.com)
  • The serotype identifies the gene product s of many HLA-A*02 alleles, including HLA-A*0201, *0202, *0203, *0206, and *0207 gene products. (academic.ru)
  • title = Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1. (academic.ru)
  • The objective of this study was to identify susceptible HLA alleles and clinical markers that can be used in risk prediction model for the early identification of severe COVID-19 among hospitalized COVID-19 patients. (cdc.gov)
  • Hundreds of versions (alleles) of HLA-B are known, each of which is given a particular number (such as HLA-B27 ). (wikipedia.org)
  • for example, at least 28 very similar alleles are subtypes of HLA-B27. (wikipedia.org)
  • Choukri F, Chakib A, Himmich H, Hue S, Caillat-Zucman S (2001) HLA-B*51 and B*15 alleles confer predisposition to Behcet's disease in Moroccan patients. (springer.com)
  • 3.In naturally exposed, partially immune Africans in The Gambia, eight largely conserved cytotoxic T-lymphocyte epitopes in P. falciparum, restricted by several different HLA class I alleles, were identified. (ox.ac.uk)
  • We also found a new haplotype, A25-Cw*12-B39-DRB1*11-DQB1*03(3.5%), in Ibizans and a more limited variability in the HLA alleles that were expressed, perhaps because of genetic isolation. (skadi.net)
  • We identified a number of HLA class I alleles in a population from Central Uganda which will enable us to carry out a functional characterization of CD8+ T-cell mediated immune responses to MTB. (biomedcentral.com)
  • Our results do not show a positive association between the HLA class I alleles and TB in this Ugandan population however the study sample was too small to draw any firm conclusions about the role of HLA class I alleles and TB development in Uganda. (biomedcentral.com)
  • Despite the fact that little significant association between HLA class I alleles and MTB susceptibility has been found, interallelic variations in the HLA class I locus may still have an impact on immune recognition due to their ability to present different peptide repertoires and thereby influencing immune recognition by antigen-specific T-cells. (biomedcentral.com)
  • The identification of HLA alleles in individuals exposed to TB in Uganda as well as determining which alleles are associated with the various TB outcomes will help in screening individuals in high-risk areas in Uganda for susceptibility to TB and also to predict their resistance to MTB infection or their progression to active TB. (biomedcentral.com)
  • Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. (uchicago.edu)
  • To the best of our knowledge, this is the first article that describes associations of HLA alleles with COVID-19 at the 4-field (highest) resolution level. (bvsalud.org)
  • Yet most HLA-associated diseases (which include infectious diseases and some forms of cancer) do not reveal a simple Mendelian mode of inheritance, either recessive or dominant, are only partially penetrant, and may involve a number of different HLA alleles in addition to non-HLA loci (3). (springer.com)
  • We applied four-color multiparameter flow cytometry (FCM), using a large panel of alloantigen-specific anti-HLA-A and -B monoclonal antibodies, to study membranous expression of individual HLA alleles in freshly isolated colorectal cancer cell suspensions from 21 patients. (beds.ac.uk)
  • Alterations in HLA class I phenotype were observed in 8 (38%) of the 21 tumors and comprised loss of a single A or B alleles in 4 cases, and loss of all four A and B alleles in the other 4 cases. (beds.ac.uk)
  • Tissue Antigens. (wikipedia.org)
  • The most accepted hypothesis proposes that for the initiation of an autoimmune disease, an immune response with pro-inflammatory characteristics needs to be directed against specific tissue antigens in genetically susceptible individuals. (frontiersin.org)
  • The crucial immunological function of the classical human major histocompatibility complex (MHC) class I molecules, human histocompatibility leukocyte antigen (HLA)-A, -B, and -C, is the presentation of peptides to T cells. (rupress.org)
  • HLA-A2 (A2) is a human leukocyte antigen " serotype " within HLA-A "A" serotype group. (academic.ru)
  • HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. (wikipedia.org)
  • Behcet's disease is an inflammation of the wall of blood vessels that can involve the eyes, skin, and the rest of the body.Human leukocyte antigen (HLA)-B5 and HLA- B51 genes are important in the pathogenesis of a disease. (apollodiagnostics.in)
  • Although cytotoxic T lymphocyte (CTL)-directed epitopes binding to human histocompatibility leukocyte antigen (HLA)-A molecules have been well characterized, those binding to HLA-B molecules have not, largely due to their large diversity. (elsevier.com)
  • Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. (nih.gov)
  • To determine the distribution of Human leukocyte antigen (HLA) class I genotypes in a Ugandan population of persons with tuberculosis (TB) and establish the relationship between class I HLA types and Mycobacterium tuberculosis (MTB) disease. (biomedcentral.com)
  • Human leukocyte antigens (HLA) are important molecules for the initiation of adaptive immune responses to infectious agents. (biomedcentral.com)
  • Human leukocyte antigen (HLA)-DR4 positivity. (mhmedical.com)
  • Ultimately, disease association with genetic factors has often been defined in terms of human leukocyte antigens (HLA), particularly those for the highly polymorphic class I and class II genes. (springer.com)
  • Human leukocyte antigen (HLA) B*51:01 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly genetically associated with Behçet's disease (BD). (mcponline.org)
  • Previous work showed an association of the hemorrhagic form with human leukocyte antigens (HLA), suggesting a role of genetic factors in disease susceptibility. (fiocruz.br)
  • Human leukocyte antigens (HLA) have been found to be associated with the pathogenesis of autoimmune diseases, allergies and inflammatory bowel diseases, and there are emerging evidences of correlations between HLA genotypes and renal diseases such as diabetic nephropathy, IgA nephropathy, and glomerulonephritis. (biomedcentral.com)
  • HLA-A80 is a human leukocyte antigen serotype HLA-a serotype group. (pp.ua)
  • Previous studies indicate that alterations in Human Leukocyte Antigen (HLA) class I expression are frequent in colorectal tumors. (beds.ac.uk)
  • Human Leukocyte Antigen (HLA) class I molecules are of major importance for cell-mediated anti-tumor immune responses. (beds.ac.uk)
  • 4.In tuberculosis patients with HLA-B52, a CD8+ cytotoxic T-lymphocyte epitope was identified in ESAT-6, a secreted antigen specific for M. tuberculosis complex but absent in BCG. (ox.ac.uk)
  • Because invasive bladder cancers are frequently reported to express MAGE, we explored the possibility of establishing a new immunotherapeutic modality against advanced bladder cancer using autologous DCs pulsed with one of the MAGE-3 epitope peptides (IMPKAGLLI), which is synthesized to bind specifically to HLA-A24. (aacrjournals.org)
  • Using this particular model, we explored the possibility of inducing a significant MAGE-specific CTL response by the in vitro stimulation of PBMCs with autologous DCs pulsed with the MAGE-3 synthetic epitope peptide, IMPKAGLLI, which binds to HLA-A24 molecules with a very high affinity. (aacrjournals.org)
  • Although the algorithms have been updated and improved over time, this approach was initially used almost 15 years ago to identify an HLA-B7-restricted T-cell epitope derived from the tumor-associated antigen carcinoembryonic antigen ( 9 ). (aacrjournals.org)
  • Additional variables considered were the host in which the epitopes were defined, the specific TB disease state associated with epitope recognition, and the HLA associated with disease susceptibility and endemic regions were also scrutinized. (neueve.com)
  • The serotype identifies the more common HLA-B*52 gene products. (wikipedia.org)
  • The serotype identifies the more common HLA-B*51 gene products. (wikipedia.org)
  • The serotype identifies the HLA-B*8101 and B*8102 (very rare) gene products . (wikidoc.org)
  • Moreover, the incidence of anti-HLA antibodies was correlated with the allelic frequencies in the Maharastrian population. (ias.ac.in)
  • Meta-analysis of all HLA antigen frequencies in chronic periodontitis revealed no positive associations, however HLA-A2 turned out to have a significantly negative association with a decreased odds ratio (Table 2 & Fig. Tab 2: Combined analysis of HLA-antigen frequencies in patients with chronic periodontitis. (amazonaws.com)
  • Tab 3: Combined analysis of HLA-antigen frequencies in patients with aggressive periodontitis. (amazonaws.com)
  • Their clinical data, including endocrine functions, were retrospectively assessed and human leucocyte antigen (HLA) genotypes were determined to compare the HLA allele frequencies in these patients and healthy controls. (elsevier.com)
  • The fetus, semiallograft by its genotype, escapes maternal allorecognition by downregulation of HLA-A and HLA-B molecules at this interface. (rupress.org)
  • We present three NK lines that are inhibited via the interaction of their NKAT3 receptor with HLA-G and with HLA-Bw4 molecules. (rupress.org)
  • Remarkably, the Vα12.1/Vβ5.6 TCR also recognized the same peptide presented by allogeneic HLA class I molecules that share the similar peptide-binding motifs, such as HLA-B*5301 and HLA-B*0702. (jimmunol.org)
  • The sensitivity of peptide recognition by the Vα12/Vβ5.6 TCR appeared to be comparable when the peptide was presented by syngeneic and allogeneic HLA class I molecules, with changes in T cell responsiveness caused largely by peptide-binding capacity. (jimmunol.org)
  • Moreover, the CTL clone bearing Vα12.1/Vβ5.6 TCR showed substantial cytolytic activity against the peptide-loaded cells expressing HLA-B*3501, HLA-B*5101, HLA-B*5301, or HLA-B*0702, providing further evidence that a single TCR complex can recognize the same peptide presented by a broad range of HLA class I molecules. (jimmunol.org)
  • A TCR with fine specificity for an HIV Ag but broad specificity to multiple HLA molecules may provide an advantage to the generation of allorestricted, peptide-specific T cells, and thus could be a potent candidate for immunotherapy against HIV infection. (jimmunol.org)
  • Cross-reactive CTLs showing dual recognition for both HLA class I and class II molecules have similarly been reported ( 3 , 4 ). (jimmunol.org)
  • In addition, self HLA-restricted CTL clones have been shown to be cross-reactive, recognizing the same peptide presented by two different syngeneic HLA class I molecules that share similar peptide-binding motifs ( 6 , 7 , 8 ). (jimmunol.org)
  • In a recent study, TCR gene transfer showed that the dual specificity of an alloreactive T cell clone that recognizes undefined peptides presented by HLA class I and class II molecules was mediated by a single TCR complex ( 10 ). (jimmunol.org)
  • It has been reported, despite their genetic diversity, that different HLA class I molecules share peptide-binding motifs ( 11 , 12 , 13 , 14 ) and that some antigenic peptides that bind to more than one HLA class I molecule are recognized by CD8 T cells in the context of one or more HLA class I restriction elements ( 6 , 7 , 15 ). (jimmunol.org)
  • In this study we report a unique cancer antigen gene, tentatively named Testin-related gene (TRG), which encodes CTL-directed epitopes on the HLA-B52 molecules most frequently expressed in Asians. (elsevier.com)
  • Therefore, this TRG-derived peptide might be appropriate for use in peptide-based immunotherapy for relatively large numbers of cancer patients throughout the world, given that 34% of Japanese, 27% of Chinese, and 13% of Caucasians express either HLA-B52 or HLA-B62 molecules. (elsevier.com)
  • Biochemical characterization of a second family of human la molecules, HLA-DS, equivalent to murine I-A subregion molecules. (springer.com)
  • These peptides were synthesized and tested for their binding ability to purified HLA-A24 molecules. (aacrjournals.org)
  • HLA genes encode cell surface molecules specialized to present antigenic peptides to T-cell receptors. (biomedcentral.com)
  • The main function of MHC molecules is to present processed peptides for the recognition of antigen-specific T cells. (frontiersin.org)
  • CD4 + T-cell epitopes are longer and are processed differently, but also must be exposed and not destroyed, and they must have affinity for HLA class II molecules instead of HLA class I. (aacrjournals.org)
  • Because only peptides that can bind to HLA class I or II provide eligible T-cell targets, one possible strategy for selecting vaccine targets is to choose candidate neoepitopes based on their predicted affinities for the HLA molecules expressed by the patient, determined using HLA-binding affinity prediction algorithms ( 6-8 ). (aacrjournals.org)
  • Researchers speculate that HLA-B27 may abnormally display to the immune system peptides that trigger arthritis. (wikipedia.org)
  • Enrichment of the unconventional non-Pro/Ala2 HLA-B*51 peptides following ERAP1 silencing. (mcponline.org)
  • Little is known about the unconventional non-Pro/Ala2 HLA-B*51-bound peptides. (mcponline.org)
  • Peptides bound to HLA-B*51:01 were eluted and analyzed by mass spectrometry. (mcponline.org)
  • More than 20% of peptides eluted from HLA-B*51:01 lacked Pro or Ala at P2. (mcponline.org)
  • This unconventional group of HLA-B*51:01-bound peptides was relatively enriched for 8-mers (with relatively fewer 9-mers) compared with the Pro2 and Ala2 subpeptidomes and had similar N-terminal and C-terminal residue usages to Ala2 peptides (with the exception of the less abundant leucine at position Ω). (mcponline.org)
  • Knockdown of ERAP1 increased the percentage of non-Pro/Ala2 from 20% to ∼40%, increased the percentage of longer (10-mer and 11-mer) peptides eluted from HLA-B*51:01 complexes, and abrogated the predominance of leucine at P1. (mcponline.org)
  • In this previous report, five peptides of nine amino acids were found to contain the binding motif for HLA-A24 in the known sequence of MAGE-3. (aacrjournals.org)
  • Only considering CD8 + T cells that recognize peptide epitopes typically 8 to 10 amino acids long, and occasionally 11 amino acids long, each mutation could generate 38 different peptides that could potentially bind to an HLA class I molecule. (aacrjournals.org)
  • It has been suggested that the maternal NK recognition of this downregulation is balanced by the expression of HLA-G, thus preventing damage to the placenta. (rupress.org)
  • The serotype is determined by the antibody recognition of α 2 subset of HLA-A α-chains. (academic.ru)
  • The serotype is determined by the antibody recognition of α 69 the subset of HLA-in the α-chain. (pp.ua)
  • In the case of B14 the recognition of the broad antigen is more useful than split antigen recognition because of the relatively poor discrimination of the split antigens see Table below. (pp.ua)
  • Defined phenotypes from tissue typing of polymorphic HLA complex enabled concentrations measurements of 1553 serum samples for HLA - A, B, and C loci determined antigens. (medscimonit.com)
  • We have studied the incidence of HLA A, B, C, DR and DQ loci antigen in Rh (D) antigen isoimmunized mothers compared to those nonimmunized isoimmunized Rh negative mothers. (ias.ac.in)
  • We have studied the allele distribution of HLA-A, -B, -Cw, -DRB1 and -DQB1 loci of 103 random, healthy, unrelated individuals belonging to the ancient Majorcan Jewish community, known locally as Chuetas, and 589 individuals from the Balearic population selected because of their typical Balearic - Majorca, Minorca or Ibiza - lineages and according to their ancestor's place of birth. (skadi.net)
  • In the current study, a retrovirus-mediated TCR transfer of individual α- and β-chains to TCR-negative hybridoma showed that Vα12.1 TCR in complex with Vβ5.6 were responsible for the peptide-specific response in the context of both HLA-B*3501 and HLA-B*5101, confirming single TCR-mediated dual specificity. (jimmunol.org)
  • However, the important question of whether a single TCR complex can recognize a single peptide presented by distinct HLA class I restriction elements remains to be examined. (jimmunol.org)
  • 2.Using a reverse immunogenetic approach, candidate epitopes from selected antigens of P. falciparum and M. tuberculosis were used to detect peptide-specific cytotoxic T-lymphocyte responses in individuals exposed to these pathogens. (ox.ac.uk)
  • Cytotoxic T-lymphocytes exhibited HLA-B52-restricted peptide-specific interferon-γ release and lytic activity and recognized endogenously processed antigen. (ox.ac.uk)
  • One TRG peptide had the ability to induce HLA-B52-restricted CTL cytotoxic to TRG + tumor cells in peripheral blood mononuclear cells (PBMC) of epithelial cancer patients. (elsevier.com)
  • This peptide also induced HLA-B62-restricted and tumor-reactive CTL in PBMC of cancer patients. (elsevier.com)
  • (14) reported the successful induction of antitumor CTLs with a MAGE-3-encoded synthetic peptide presented by HLA-A24. (aacrjournals.org)
  • HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance? (deepdyve.com)
  • HLA B*48 haplotypes indicate a means of passage to the New World along the Siberian Coast, a possible land route of passage through Beringia or later by boat across the bering strait into the New World. (wikidoc.org)
  • Characteristic Jewish haplotypes, A26-B38-DRB1*13, A24-B38-DRB1*11, A1-B52-DRB1*15/16, were found in our study. (skadi.net)
  • Using HLA haplotypes as pituitary irAE predictive markers, we could provide safe ICPi treatment and understand irAE pathogenesis. (elsevier.com)
  • Cloning and sequencing full-length HLA-B and -C genes" (PDF). (wikipedia.org)
  • The HLA-G gene has the same general structure as the classical MHC class I genes with five exons and three introns. (rupress.org)
  • Polymorphisms in the vitamin D receptor and Fc-gamma receptor genes may be protective for severe dengue, whereas certain human platelet antigen allele polymorphisms are seen more frequently in patients with DSS. (renalandurologynews.com)
  • High-resolution sequencing-based typing for eight HLA genes was performed using next-generation sequencing. (cdc.gov)
  • In humans, the HLA-B gene and two related genes, HLA-A and HLA-C , are the major genes in MHC class I. (wikipedia.org)
  • HLA class I antigens are encoded by a family of highly polymorphic genes, with each allele responsible for a different repertoire of antigen presentation. (beds.ac.uk)
  • B5 is a broad antigen serotype that recognizes the B51 and B52 split antigen serotypes. (wikipedia.org)
  • HLA-A28 HLA broad antigen is one serotype that recognized the A68 and A69 serotypes. (pp.ua)
  • HLA-A9 broad antigen HLA-a single serotype that recognized the HLA-A23 and HLA-A24 serotypes. (pp.ua)
  • The phenotypes and genotypes of 53 blood antigens of 26 patients were incompatible. (bvsalud.org)
  • MICA was originally pointed out to be an HLA-related polymorphic gene, the product of which may be recognized by a subpopulation of intestinal gamma delta T-cells and may play a role in the activation of a subpopulation of natural killer cells. (terasaki.org)
  • Several epitopes were also recognized in Tanzanians and cytotoxic T-lymphocytes recognized endogenously processed antigen. (ox.ac.uk)
  • Furthermore, regardless of the total number, only a fraction of mutations are expected to generate HLA-binding (known as MHC in mice) epitopes capable of serving as relevant vaccine targets, and it is possible that attempting to target all possible mutant neoepitopes may drown out the relevant targets and reduce efficacy. (aacrjournals.org)
  • At a minimum, it will be necessary to choose (or at least enrich for) vaccine targets that are actually processed and presented by antigen-presenting cells and presented on HLA by the tumor to activate the T cells that can recognize these epitopes and mediate tumor lysis. (aacrjournals.org)
  • Most importantly epitopes have apparently been defined from only 7% of all ORFs, and the top 30 most frequently studied protein antigens contain 65% of the epitopes, leaving the majority of M. tuberculosis genome unexplored. (neueve.com)
  • Variability of concentrations of s-HLA-I depending on allelic specificity substantiated realisation of research in population of 248 healthy, unrelated individuals. (medscimonit.com)
  • For most of numbers of the allelic specificity the concentration of antigen material in soluble form (s-HLA-I) in blood serum were nominally very high and high. (medscimonit.com)
  • Authors point on usefulness of results for s-HLA comparative analysis of particular HLA allelic specificity, specific for certain diseases e.g. (medscimonit.com)
  • The following is a list of those specificities which arose as clear-cut splits of other specificities and of associated antigens (#) which are variants of the original broad specificity and not splits as previously defined. (alleles.org)
  • Specificity, sensitivity, positive and negative predictive values of hemagglutination method for RhD antigen had good values in comparison to the molecular method. (bvsalud.org)
  • The area under the curve of the risk prediction model utilizing HLA-A*11:01:01:01, age at diagnosis, and sex at birth was 0.772, with sensitivity of 0.715 and specificity of 0.717. (bvsalud.org)
  • In RAU, genetic and environment factors affecting the Th1/Th2 balance may contribute to low tolerance, thereby permitting a cytotoxic immune response against antigens present on normal oral epithelium that are similar to foreign ones. (hindawi.com)
  • A pre-operative direct cross-match was negative by a conventional cytotoxic test, and HLA class 1 and 2 antibodies were negative by LABScreen single antigen testing. (terasaki.org)
  • 5.These studies demonstrate that CD8+ cytotoxic T-lymphocytes specific for mycobacterial and protozoal antigens are induced during natural infections in humans. (ox.ac.uk)
  • The identification of these T-cells endorses current strategies to develop cytotoxic T-lymphocyte-inducing vaccines against P. falciparum and M. tuberculosis and highlights candidate antigens for inclusion in subunit vaccines. (ox.ac.uk)
  • 1981). "Host factors and susceptibility to rubella virus infection: the association of HLA antigens" . (wikipedia.org)
  • An individual's HLA profile can determine resistance or susceptibility to certain infectious diseases, e.g. (biomedcentral.com)
  • HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. (springer.com)
  • The current work suggests that HLA-DR3 (odds ratio = 1.91, 95 % CI = 1.098-3.324, P = 0.024, Pc = 0.312) and HLA-DR11 (odds ratio = 2.06, 95 % CI = 1.133-3.761, P = 0.021, P c = 0.273) may represent susceptibility risk factors for the development of ESRD in Taiwanese individuals. (biomedcentral.com)
  • A dual specific human CTL clone harboring one β and two inframe α transcripts of TCR was previously reported to recognize an HIV Pol-derived nonapeptide (IPLTEEAEL) endogenously presented by both syngeneic HLA-B*3501 and HLA-B*5101. (jimmunol.org)
  • HLA-B ( major histocompatibility complex, class I, B ) is a human gene that provides instructions for making a protein that plays a critical role in the immune system . (wikipedia.org)
  • HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (wikipedia.org)
  • Among people with human immunodeficiency virus (HIV) infection, a version of HLA-B designated HLA-B*5701 is associated with an extreme sensitivity to abacavir . (wikipedia.org)
  • HLA disease associations-Models for the study of complex human genetic disorders. (springer.com)
  • To determine the frequency of different HLA- antigens in patients with plaque psoriasis in the Omani Arab population. (bvsalud.org)
  • The Yucpa have an HLA-DQ8 frequency of ~80%, the highest DQ allele frequency in the world, this tribe shows little evidence of European genetic introgression, in addition the closest DQ8 frequency in terms of Africa are the isolated !Kung of Namibia. (wikidoc.org)
  • The decline in ESAT-6-specific T cells with effective chemotherapy, which reduces bacterial load by several orders of magnitude, suggests that, within a given individual, for the frequency of ESAT-6-specific T cells, as enumerated by the ex vivo ELISPOT, is related to antigen load. (allindianpatents.com)
  • In biological systems where the in vivo burden of a pathogen and the corresponding antigen load are measurable, it is recognised that the frequency .of antigen-specific T cells enumerated ex vivo, correlates with, and is in part driven by, the antigen load. (allindianpatents.com)
  • B58 baron manuals katzenstore, internal dynamic shadows on vc, volumetric normal mapping, specular mapping and bloom lights polygon optimized The HLA-B58 allele was present in all patients with allopurinol-induced SCARs, while the frequency of HLA-B58 was only 9. (nvision08.com)
  • However, Lee (2001), gives a general idea of the odds with the following statement: "In humans, Behçet's disease occurs in only 1 of 1000 individuals who have the HLA-B51 phenotype. (blogspot.com)
  • Seven of these 8 tumors were located on the right side of the colon, and those showing loss of both HLA-A and -B membranous expression were all of the MSI-H phenotype. (beds.ac.uk)
  • Hence, an effective tumor immune escape mechanism could occur through a subtle alteration of the tumor cell HLA phenotype, circumventing both CTL and NK cell attack. (beds.ac.uk)
  • The serotype identifies the B*45 gene-allele protein products of HLA-B. (pp.ua)
  • B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101. (wikipedia.org)
  • Recent investigations have demonstrated the efficacy of autologous dendritic cells (DCs) pulsed with tumor antigens to generate tumor-specific CTLs against cancer cells. (aacrjournals.org)
  • 2003) Mapping the HLA association in Behcet's disease: a role for tumor necrosis factor polymorphisms? (springer.com)
  • Interestingly, ERAP1 polymorphisms only affect BD risk in HLA-B*51-positive individuals ( 2 , 3 ). (mcponline.org)
  • The polymorphisms of HLA class I and II antigens in ESRD patients and a healthy control group were retrospectively analyzed. (biomedcentral.com)
  • In this study, HLA class I and II polymorphisms of ESRD patients were compared to a healthy control group in an effort to provide a better understanding of the etiology of this disease. (biomedcentral.com)
  • Involved in the presentation of foreign antigens to the immune system. (monash.edu)
  • The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria . (wikipedia.org)
  • The HLA-B gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign invaders. (wikipedia.org)
  • In many cases, chronic inflammatory diseases are autoimmune diseases that are caused by a loss of tolerance to self-antigens due to inappropriate activation of the immune system. (frontiersin.org)
  • 1987) HLA-B*51 may serve as an immunogenetic marker for a subgroup of patients with Behcet's syndrome. (springer.com)
  • This test is useful in the pathogenesis of a disease called Behcet's disease.HLA B5 has two splits B51 and B52. (apollodiagnostics.in)
  • Positive result in the HLA- B51 test indicates increase in the risk for Behcet's disease by six times. (apollodiagnostics.in)
  • HLA blood testing can help in diagnosis of Behcet's disease, although patients need to understand that the results are not specific to Behçet's (they also appear in people with other illnesses, and in people who are perfectly healthy), the test is expensive, it may not be covered by health insurance, and the final report can take weeks to arrive. (blogspot.com)
  • If doctors are on the borderline between diagnosing you with Behcet's, MS, or lupus (or a combination of 2 of them, which is also possible), your total HLA "picture" will give them more information to work with. (blogspot.com)
  • It's important to know that you don't have to show ANY of the typical Behcet's-related HLA types in order to be diagnosed with Behçet's: physicians base a diagnosis on a combination of observed physical signs and symptoms, their personal experience in treating Behçet's patients, the patient's medical history, and the patient's test results. (blogspot.com)
  • Melanoma antigens (MAGE) are a family of tumor-specific antigens shown to be expressed in various tumors, including bladder cancers and melanoma, but not in normal tissues except for the testis. (aacrjournals.org)
  • HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. (uchicago.edu)
  • Cullinan MP, Sachs J, Wolf E, Seymour GJ: The distribution of HLA-A and -B antigens in patients and their families with periodontosis. (amazonaws.com)
  • Although most patients with ankylosing spondylitis have the HLA-B27 variation, many people with this particular variation never develop the disorder. (wikipedia.org)
  • Accurate determination of red blood cells [RBCs] antigens is very important in multitransfused patients including beta-thalassemics and sickle cell anemics. (bvsalud.org)
  • So, the aim of this study was to evaluate DNA- based methods as supplement to the hemagglutination technique to determine the red blood cell [RBC] antigen profile of multitransfused patients with beta- thalassemia. (bvsalud.org)
  • Blood typing by serologic method was not accurate in this study but genotyping could determine true blood groups in multitransfused patients and help in selection of RBCs without alloimmunized antigens in future transfusion attempts. (bvsalud.org)
  • Fifty four Omani patients clinically diagnosed with plaque psoriasis attending the dermatology outpatient clinic in Al-Nahdah Hospital [the tertiary dermatology centre in Oman] were selected for HLA studies. (bvsalud.org)
  • HLA-B52 was present in 20.4% of patients 11/54 and in 5% of controls without psoriasis 5/100. (bvsalud.org)
  • HLA type screening results revealed that HLA-DR15, B52 and Cw12 were observed in 9, 7, and 7 patients with pituitary irAE, respectively. (elsevier.com)
  • Research over several decades has shown that HLA-B5 is found more often in the blood of Behçet's patients in Japan, Italy, Korea and Turkey, than in healthy people. (blogspot.com)
  • There is apparently no relationship between HLA results and Behçet's disease for patients in the US(12) and the UK(13). (blogspot.com)
  • Patients and controls - Sixty-four white Brazilian patients, living in the state of Paraná, Southern Brazil, were serologically typed for HLA class I and II antigens. (fiocruz.br)
  • A total of four HLA-A24+ patients with advanced MAGE-3+ bladder cancers were treated with s.c. injections of autologous DCs pulsed with IMPKAGLLI every 2 weeks for a minimum of 6 and a maximum of 18 times. (aacrjournals.org)
  • The information of 141 ESRD patients was obtained from the medical record of the Keelung branch of Chang Gung Memorial Hospital and was compared to the HLA type of a control group comprized of 190 healthy unrelated Taiwanese from one of our previous studies. (biomedcentral.com)
  • HLA typing might be a useful clinical method for screening patients with high risk of progression to ESRD. (biomedcentral.com)
  • Dannenmann SR, Hermanns T, Bransi A, Matter C, von Boehmer L, Stevanovic S, Schraml P, Moch H, Knuth A, van den Broek M (2013) Spontaneous peripheral T cell responses towards the tumor-associated antigen Cyclin D1 in patients with clear cell renal cell carcinoma. (immunology-tuebingen.de)
  • The positive rate of HLA-B58 was significantly higher in patients with SCARs than in the allopurinol-tolerant group [odds ratio (OR) = 179. (nvision08.com)
  • Although there are no quantitative absolute measures of bacterial or antigen load in TB, they must be directly and closely inter-related, and ex vivo quantitation of ESAT-6-specific T cells thus offers a means for longitudinally tracking changes inM tuberculosis bacterial load within an individual. (allindianpatents.com)
  • Conclusions: HLA-DR15, B52 and Cw12 are possible predisposing factors for pituitary irAEs. (elsevier.com)
  • A version of the HLA-B gene called HLA-B27 increases the risk of developing ankylosing spondylitis. (wikipedia.org)
  • HLA-B27 is associated with the spondyloarthropathies , a group of disorders that includes ankylosing spondylitis and other inflammatory joint diseases. (wikipedia.org)
  • Similar epistatic interactions between HLA class I and ERAP1 have been reported in HLA-B*27-associated ankylosing spondylitis and HLA-C*0602-associated psoriasis ( 4 , 5 ). (mcponline.org)
  • B52 is a split antigen of the broad antigen B5, and is a sister type of B51. (wikipedia.org)
  • HLA A30 (19) split antigen was not identified in immunized women while HLA A23 (9) split antigen was not identified in non immunized women. (ias.ac.in)
  • There is not enough data to demonstrate whether the associations of HLA-A9 and -B5 in aggressive periodon-titis were caused by association of only one or both of their split antigens (HLA-A23, -A24 and HLA-B51, -B52). (amazonaws.com)
  • split antigen (plural split antigens) (biochemistry) In the testing of cell surface antigens, an antigen that has a more refined or specific cell surface reaction relative to a broad antigen. (international-dictionary.com)
  • Visitors are welcome to help us expand the meaning of split antigen . (international-dictionary.com)
  • Please help us expand the meaning of split antigen by providing an alternate definition or example above. (international-dictionary.com)
  • The serotype is a split antigen serotype also recognized by the broad antigen serotype A28 . (wikidoc.org)
  • B14 is a broad antigen composed to two, B64 and B65, split antigens. (pp.ua)
  • Antenatal sera from 1334 pregnant women attending the Nowrojee B J Wadia Maternity Hospital and KEM Hospital in Parel, Mumbai were collected and screened for anti HLA A and B antibodies to produce an indigenous HLA tissue typing tray. (ias.ac.in)
  • One hundred and sixty three sera (12.2%) were found positive for HLA antibodies. (ias.ac.in)
  • Standard methods of serological HLA typing, ABO and Rh (D) groups, and screening for Rh D antibodies were used. (ias.ac.in)
  • HLA class 1 and 2 antibodies were negative during this period, and MICA019 antibody was higher before transplantation retrospectively. (terasaki.org)
  • This meta-analysis shows evidence that aggressive periodontitis among Caucasians is associated with HLA-A9 and -B15. (amazonaws.com)
  • DR15: 81.8% vs 33.5% (n = 11, P = 0.0014), B52: 63.6% vs 21.0% (n = 11, P = 0.0026) and Cw12: 70% vs 21.3% (n = 10, P = 0.0013). (elsevier.com)
  • HLA-DR15 is reportedly associated with autoimmune disease via interleukin-17 regulation, suggesting its involvement in pituitary irAE development. (elsevier.com)
  • Therefore, these antigens are considered to be attractive targets for anticancer immunotherapy. (aacrjournals.org)
  • FCM allows the discrimination of complex phenotypes related to the expression of HLA class I. The different patterns of HLA class I expression might underlie different tumor behavior and influence the success rate of immunotherapy. (beds.ac.uk)
  • Shapira L, Eizenberg S, Sela MN, Soskolne A, Brautbar H: HLA A9 and B15 are associated with the generalized form, but not the localized form, of early-onset periodontal diseases. (amazonaws.com)
  • Kaslick RS, West TL, Chasens AI, Terasaki PI, Lazzara R, Weinberg S: Association between HL-A2 antigen and various periodontal diseases in young adults. (amazonaws.com)
  • HLA-C and HLA-D testing was not performed (although I wish it had been, because new HLA links to various diseases are being found every year). (blogspot.com)
  • Even if you don't carry any of the typical BD-type results, researchers have found links between some HLA results and other autoimmune and/or rheumatic diseases. (blogspot.com)
  • Failing immunological tolerance for critical self-antigens is the problem underlying most chronic inflammatory diseases of humans. (frontiersin.org)
  • However, there is an increasing understanding that pro-inflammatory responses directed to self-antigens become chronic in autoimmune diseases because regulatory mechanisms fail to control them. (frontiersin.org)
  • Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. (springer.com)