An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.
A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.
Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H3 receptors were first recognized as inhibitory autoreceptors on histamine-containing nerve terminals and have since been shown to regulate the release of several neurotransmitters in the central and peripheral nervous systems. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to histamine, forming N-methylhistamine, the major metabolite of histamine in man. EC
A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
Histamine substituted in any position with one or more methyl groups. Many of these are agonists for the H1, H2, or both histamine receptors.
An enzyme that catalyzes the decarboxylation of histidine to histamine and carbon dioxide. It requires pyridoxal phosphate in animal tissues, but not in microorganisms. EC
A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.
Drugs that selectively bind to but do not activate HISTAMINE H3 RECEPTORS. They have been used to correct SLEEP WAKE DISORDERS and MEMORY DISORDERS.
Drugs used for their actions on histaminergic systems. Included are drugs that act at histamine receptors, affect the life cycle of histamine, or affect the state of histaminergic cells.
A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
A histamine H2 receptor antagonist that is used as an anti-ulcer agent.
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
A potent mast cell degranulator. It is involved in histamine release.
Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.
A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.
The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)
Hydrochloric acid present in GASTRIC JUICE.
A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
A group of compounds that are derivatives of beta-methylacetylcholine (methacholine).
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.
A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
Neuroendocrine cells in the glands of the GASTRIC MUCOSA. They produce HISTAMINE and peptides such as CHROMOGRANINS. ECL cells respond to GASTRIN by releasing histamine which acts as a paracrine stimulator of the release of HYDROCHLORIC ACID from the GASTRIC PARIETAL CELLS.
Histidine substituted in any position with one or more methyl groups.
An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.
A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A family of hexahydropyridines.
A plant genus of the family FABACEAE that is the source of mucuna gum.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Spasmodic contraction of the smooth muscle of the bronchi.
A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Abnormal passage communicating with the STOMACH.
Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
A subtype of enteroendocrine cells found in the gastrointestinal MUCOSA, particularly in the glands of PYLORIC ANTRUM; DUODENUM; and ILEUM. These cells secrete mainly SEROTONIN and some neuropeptides. Their secretory granules stain readily with silver (argentaffin stain).
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.
A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
The sudden, forceful, involuntary expulsion of air from the NOSE and MOUTH caused by irritation to the MUCOUS MEMBRANES of the upper RESPIRATORY TRACT.

Major changes in the brain histamine system of the ground squirrel Citellus lateralis during hibernation. (1/3980)

Hibernation in mammals such as the rodent hibernator Citellus lateralis is a physiological state in which CNS activity is endogenously maintained at a very low, but functionally responsive, level. The neurotransmitter histamine is involved in the regulation of diurnal rhythms and body temperature in nonhibernators and, therefore, could likely play an important role in maintaining the hibernating state. In this study, we show that histamine neuronal systems undergo major changes during hibernation that are consistent with such a role. Immunohistochemical mapping of histaminergic fibers in the brains of hibernating and nonhibernating golden-mantled ground squirrels (C. lateralis) showed a clear increase in fiber density during the hibernating state. The tissue levels of histamine and its first metabolite tele-methylhistamine were also elevated throughout the brain of hibernating animals, suggesting an increase in histamine turnover during hibernation, which occurs without an increase in histidine decarboxylase mRNA expression. This hibernation-related apparent augmentation of histaminergic neurotransmission was particularly evident in the hypothalamus and hippocampus, areas of importance to the control of the hibernating state, in which tele-methylhistamine levels were increased more than threefold. These changes in the histamine neuronal system differ from those reported for the metabolic pattern in other monoaminergic systems during hibernation, which generally indicate a decrease in turnover. Our results suggest that the influence of histamine neuronal systems may be important in controlling CNS activity during hibernation.  (+info)

Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea. (2/3980)

The ability of the M2 muscarinic receptor to mediate an inhibition of the relaxant effects of forskolin and isoproterenol was investigated in guinea pig ileum and trachea. In some experiments, trachea was first treated with 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) mustard to inactivate M3 receptors. The contractile response to oxotremorine-M was measured subsequently in the presence of both histamine (10 microM) and isoproterenol (10 nM). Under these conditions, [[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5, 11-dihydro-6H-pyrido[2,3b]-[1,4]benzodiazepine-6-one (AF-DX 116) antagonized the contractile response to oxotremorine-M in a manner consistent with an M3 mechanism. However, when the same experiment was repeated using forskolin (4 microM) instead of isoproterenol, the response to oxotremorine-M exhibited greater potency and was antagonized by AF-DX 116 in a manner consistent with an M2 mechanism. We also measured the effects of pertussis toxin treatment on the ability of isoproterenol to inhibit the contraction elicited by a single concentration of either histamine (0.3 microM) or oxotremorine-M (40 nM) in both the ileum and trachea. Pertussis toxin treatment had no significant effect on the potency of isoproterenol for inhibiting histamine-induced contractions in the ileum and trachea. In contrast, pertussis toxin treatment enhanced the relaxant potency of isoproterenol against oxotremorine-M-induced contractions in the ileum but not in the trachea. Also, pertussis toxin treatment enhanced the relaxant potency of forskolin against oxotremorine-M-induced contractions in the ileum and trachea. We investigated the relaxant potency of isoproterenol when very low, equi-effective (i.e., 20-34% of maximal response) concentrations of either histamine or oxotremorine-M were used to elicit contraction. Under these conditions, isoproterenol exhibited greater relaxant potency against histamine in the ileum but exhibited similar relaxant potencies against histamine and oxotremorine-M in the trachea. Following 4-DAMP mustard treatment, a low concentration of oxotremorine-M (10 nM) had no contractile effect in either the ileum or trachea. Nevertheless, in 4-DAMP mustard-treated tissue, oxotremorine-M (10 nM) reduced the relaxant potency of isoproterenol against histamine-induced contractions in the ileum, but not in the trachea. We conclude that in the trachea the M2 receptor mediates an inhibition of the relaxant effects of forskolin, but not isoproterenol, and the decreased relaxant potency of isoproterenol against contractions elicited by a muscarinic agonist relative to histamine is not due to activation of M2 receptors but rather to the greater contractile stimulus mediated by the M3 receptor compared with the H1 histamine receptor.  (+info)

Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. (3/3980)

Urocortin (Ucn) is related to corticotropin-releasing hormone (CRH), and both are released in the brain under stress where they stimulate CRH 1 and 2 receptors (CRHR). Outside the brain, they may have proinflammatory actions through activation of mast cells, which are located perivascularly close to nerve endings and degranulate in response to acute psychological stress. Here, we report that a concentration of intradermal Ucn as low as 10 nM induced dose-dependent rat skin mast cell degranulation and increased vascular permeability. This effect appeared to be equipotent to that of calcitonin gene-related peptide and neurotensin. Ucn-induced skin vasodilation was inhibited by pretreatment with the mast cell stabilizer disodium cromoglycate (cromolyn) and was absent in the mast cell-deficient W/Wv mice. The selective nonpeptide CRH receptor 1 antagonist, antalarmin and the nonselective peptide antagonist astressin both reduced vascular permeability triggered by Ucn but not that by Substance P or histamine. In contrast, the peptide antagonist alpha-helical CRH-(9-41) reduced the effect of all three. The vasodilatory effect of Ucn was largely inhibited by pretreatment with H1 receptor antagonists, suggesting that histamine is the major mediator involved in vitro. Neuropeptide depletion of sensory neurons, treatment with the ganglionic blocker hexamethonium, or in situ skin infiltration with the local anesthetic lidocaine did not affect Ucn-induced vascular permeability, indicating that its in situ effect was not mediated through the peripheral nervous system. These results indicate that Ucn is one of the most potent triggers of rat mast cell degranulation and skin vascular permeability. This effect of Ucn may explain stress-induced disorders, such as atopic dermatitis or psoriasis, and may lead to new forms of treatment.  (+info)

Dynamic and quantitative Ca2+ measurements using improved cameleons. (4/3980)

Cameleons are genetically-encoded fluorescent indicators for Ca2+ based on green fluorescent protein variants and calmodulin (CaM). Because cameleons can be targeted genetically and imaged by one- or two-photon excitation microscopy, they offer great promise for monitoring Ca2+ in whole organisms, tissues, organelles, and submicroscopic environments in which measurements were previously impossible. However, the original cameleons suffered from significant pH interference, and their Ca2+-buffering and cross-reactivity with endogenous CaM signaling pathways was uncharacterized. We have now greatly reduced the pH-sensitivity of the cameleons by introducing mutations V68L and Q69K into the acceptor yellow green fluorescent protein. The resulting new cameleons permit Ca2+ measurements despite significant cytosolic acidification. When Ca2+ is elevated, the CaM and CaM-binding peptide fused together in a cameleon predominantly interact with each other rather than with free CaM and CaM-dependent enzymes. Therefore, if cameleons are overexpressed, the primary effect is likely to be the unavoidable increase in Ca2+ buffering rather than specific perturbation of CaM-dependent signaling.  (+info)

On the mechanism of histaminergic inhibition of glutamate release in the rat dentate gyrus. (5/3980)

1. Histaminergic depression of excitatory synaptic transmission in the rat dentate gyrus was investigated using extracellular and whole-cell patch-clamp recording techniques in vitro. 2. Application of histamine (10 microM, 5 min) depressed synaptic transmission in the dentate gyrus for 1 h. This depression was blocked by the selective antagonist of histamine H3 receptors, thioperamide (10 microM). 3. The magnitude of the depression caused by histamine was inversely related to the extracellular Ca2+ concentration. Application of the N-type calcium channel blocker omega-conotoxin (0. 5 or 1 microM) or the P/Q-type calcium channel blocker omega-agatoxin (800 nM) did not prevent depression of synaptic transmission by histamine. 4. The potassium channel blocker 4-aminopyridine (4-AP, 100 microM) enhanced synaptic transmission and reduced the depressant effect of histamine (10 microM). 4-AP reduced the effect of histamine more in 2 mM extracellular calcium than in 4 mM extracellular calcium. 5. Histamine (10 microM) did not affect the amplitude of miniature excitatory postsynaptic currents (mEPSCs) and had only a small effect on their frequency. 6. Histaminergic depression was not blocked by an inhibitor of serine/threonine protein kinases, H7 (100 microM), or by an inhibitor of tyrosine kinases, Lavendustin A (10 microM). 7. Application of adenosine (20 microM) or the adenosine A1 agonist N6-cyclopentyladenosine (CPA, 0.3 microM) completely occluded the effect of histamine (10 microM). 8. We conclude that histamine, acting on histamine H3 receptors, inhibits glutamate release by inhibiting presynaptic calcium entry, via a direct G-protein-mediated inhibition of multiple calcium channels. Histamine H3 receptors and adenosine A1 receptors act upon a common final effector to cause presynaptic inhibition.  (+info)

Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. (6/3980)

Neutrophilic inflammation in small airways (SA) and bronchospasm mediated via muscarinic receptors are features of chronic obstructive pulmonary disease in horses (COPD). Histamine, serotonin, and leukotrienes (LTs) are reported to be involved in the exacerbation of COPD, and currently, histamine has been shown to increase tension response to electrical field simulation (EFS) in equine SA. We tested the effects of these mediators and the effects of activated neutrophils on the cholinergic responses in SA. Histamine, serotonin, and LTD4 had a synergistic effect on EFS responses and only an additive effect on the tension response to exogenous ACh or methacholine. Atropine and TTX entirely eliminated the EFS-induced tension response in the presence of all three inflammatory mediators, indicating that augmentation of the EFS response applies only to the endogenous cholinergic response. Neutrophils isolated from control and COPD-affected horses were activated by zymosan, producing 18.1 +/- 2.3 and 25.0 +/- 2.3 nmol superoxide. 10(6) cells-1. 30 min-1, respectively. However, in contrast to the profound effect of mediators, incubation of SA for over 1 h in a suspension of up to 30 x 10(6) zymosan-treated neutrophils/ml did not significantly affect EFS responses of SA isolated from either control or COPD-affected horses. We conclude that in equine SA 1) the endogenous cholinergic responses are subject to strong facilitation by inflammatory mediators; 2) activated neutrophils do not affect cholinergic responses in SA; and 3) in acute bouts of equine COPD, histamine, LTD4, and serotonin (mediators primarily associated with type I allergic reaction) rather than mediators derived from neutrophils most likely contribute to increased cholinergic airway tone.  (+info)

Exhaled nitric oxide; relationship to clinicophysiological markers of asthma severity. (7/3980)

Bronchial asthma is an airway disorder associated with bronchial hyperresponsiveness, variable airflow obstruction and elevated levels of nitric oxide (NO) in exhaled air. The variables all reflect, in part, the underlying airway inflammation in this disease. To understand their interrelationships we have investigated the relationship between exhaled NO levels and clinicophysiological markers of asthma severity. Twenty-six steroid naive atopic asthmatics participated in the analysis. All were given diary cards and were asked to record their peak expiratory flow (PEF) rates twice daily together with their asthma symptom scores and beta-agonist use. Diary cards were collected 2 weeks later and measurements of exhaled NO levels, FEV1 and histamine bronchial hyperreactivity (PC20 histamine) were undertaken. Exhaled NO levels were significantly higher in our study population than in normal control subjects and correlated negatively with PC20 histamine (r = -0.51; P = 0.008) and positively with PEF diurnal variability (r = 0.58; P = 0.002), but not with symptom scores, beta-agonist use of FEV1 (%). We conclude that a significant relationship exists between exhaled NO levels and the two characteristic features and markers of asthma severity, namely bronchial hyperreactivity and PEF diurnal variability. The lack of correlation between symptom score and beta-agonist use, of FEV1 (%) predicted and exhaled NO suggests that these measures are reflective of differing aspects of asthma.  (+info)

Strain-dependent induction of allergic sensitization caused by peanut allergen DNA immunization in mice. (8/3980)

To investigate the potential application of allergen gene immunization in the modulation of food allergy, C3H/HeSn (C3H) mice received i.m. injections of pAra h2 plasmid DNA encoding one of the major peanut allergens, Ara h2. Three weeks following pDNA immunization, serum Ara h2-specific IgG2a, IgG1, but not IgE, were increased significantly in a dose-dependent manner. IgG1 was 30-fold higher in multiply compared with singly immunized mice. Ara h2 or peanut protein injection of immunized mice induced anaphylactic reactions, which were more severe in multiply immunized mice. Heat-inactivated immune serum induced passive cutaneous anaphylaxis, suggesting that anaphylaxis in C3H mice was mediated by IgG1. IgG1 responses were also induced by intradermal injection of pAra h2, and by i.m. injection of pOMC, the plasmid DNA encoding the major egg allergen protein, ovomucoid. To elucidate whether the pDNA immunization-induced anaphylaxis was a strain-dependent phenomenon, AKR/J and BALB/c mice also received multiple i.m. pAra h2 immunizations. Injection of peanut protein into these strains at weeks 3 or 5 following immunization did not induce reactions. Although IgG2a was increased significantly from week 2 in AKR/J mice and from week 4 in BALB/c mice and remained elevated for at least 6 wk, no IgG1 or IgE was detected. These results indicate that the type of immune responses to pDNA immunization in mice is strain dependent. Consequently, models for studying human allergen gene immunization require careful selection of suitable strains. In addition, this suggests that similar interindividual variation is likely in humans.  (+info)

TY - JOUR. T1 - Regulation of plasma histamine levels by the mast cell clock and its modulation by stress. AU - Nakamura, Yuki. AU - Ishimaru, Kayoko. AU - Shibata, Shigenobu. AU - Nakao, Atsuhito. PY - 2017/1/11. Y1 - 2017/1/11. N2 - At steady state, plasma histamine levels exhibit circadian variations with nocturnal peaks, which is implicated in the nighttime exacerbation of allergic symptoms. However, the regulatory mechanisms are largely unexplored. This study determined how steady-state plasma histamine levels are regulated and affected by environmental factors. We found that plasma histamine levels decreased in mast cell-deficient mice and their circadian variations were lost in mast cell-deficient mice reconstituted with bone marrow-derived mast cells (BMMCs) harboring a mutation in the circadian gene Clock. Clock temporally regulates expression of organic cation transporter 3 (OCT3), which is involved in histamine transport, in mast cells; OCT inhibition abolished circadian variations in ...
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Global and Chinese Histamine Dihydrochloride Industry, 2017 Market Research Report The Global and Chinese Histamine Dihydrochloride Industry, 2012-2022 Market Research Report is a professional and - Market research report and industry analysis - 10790459
TY - JOUR. T1 - Airway blood flow distribution and lung edema after histamine infusion in awake sheep. AU - Kramer, G. C.. AU - Lindsey, D. C.. AU - Wu, C. H.. AU - Mertens, S.. AU - Russell, L. A.. AU - Cross, Carroll E. PY - 1988. Y1 - 1988. N2 - The present study was designed to evaluate the distribution of bronchial blood flow to major airways and peripheral lung and to quantitate lung edema during a 2-h histamine infusion (2 μg·kg-1·min-1) in unanesthetized sheep. By the use of radioactive microspheres, the blood flow to trachea and to tracheal cartilage, smooth muscle, and mucosa/submucosa was determined along with measurements of blood flow to different sized airway segments and the systemic blood flow to lung parenchyma. Histamine greatly increased blood flow to medium-sized (5- to 10-mm-diam) central airways in which blood flow increased 5-10 times base line, whereas in small (1- to 5-mm-diam) central airways the increase was 10-15 times. Blood flow in tracheal mucosa/submucosa ...
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TY - JOUR. T1 - Results from a randomized phase III study comparing combined treatment with histamine dihydrochloride plus interleukin-2 versus interleukin-2 alone in patients with metastatic melanoma. AU - Agarwala, S. S.. AU - Glaspy, J.. AU - ODay, S. J.. AU - Mitchell, M.. AU - Gutheil, J.. AU - Whitman, E.. AU - Gonzalez, R.. AU - Hersh, E.. AU - Feun, L.. AU - Belt, R.. AU - Meyskens, F.. AU - Hellstrand, K.. AU - Wood, D.. AU - Kirkwood, J. M.. AU - Gehlsen, K. R.. AU - Naredi, P.. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Purpose: Reactive oxidative species (ROS) produced by phagocytic cells have been ascribed a role in the localized suppression of lymphocyte function within malignant tumors. Histamine has been shown to inhibit ROS formation and possibly synergize with cytokines to permit activation of natural killer cells and T cells. This study was designed to determine whether the addition of histamine to a subcutaneous (SC) regimen of interleukin-2 (IL-2) would improve the survival of ...
TY - JOUR. T1 - Role of endogenous histamine in altered lung mechanics in rabbits. AU - Habre, Walid. AU - Babik, Barna. AU - Chalier, Michel. AU - Peták, F.. PY - 2002. Y1 - 2002. N2 - Background: Unlike the effects of exogenous histamine, those of endogenous histamine on the lung mechanics have not yet been characterized. The site of endogenous histamine liberation by mivacurium was determined, as were the effects of this histamine on the airway and parenchymal mechanics in control rabbits (group C) and rabbits pretreated with H1 and H2 receptor blockers (group AH). The effectiveness of the receptor blockade was ensured by challenges with exogenous histamine. Methods: Pulmonary input impedance at low frequencies (ZL) was measured in anesthetized mechanically ventilated open-chest rabbits under control conditions and every minute after administration of an intravenous bolus of mivacurium (2 mg/kg) and exogenous histamine (10 μg/kg). Histamine levels were determined in serum samples taken from ...
Histamine intolerance occurs when the body is unable to adequately process the level of histamine present in the body. When DAO levels are low or its activity is inhibited, signs of excess histamine can appear.. Histamine is a powerful compound that is essential to our health. Excess histamine, however, can cause discomfort and distress. Those who are histamine sensitive or histamine intolerant experience allergy-like symptoms in response to excess histamine consumed in foods, triggered by foods, or released in response to environmental factors. In rare cases, excess histamine is produced to excess by the bodys own mast cells (see Histamine and Mast Cells).. Common signs of histamine sensitivity or intolerance include flushing of the skin, rash, itching (esp. eyes, ears, nose), acute temporary rhinitis (sneezing, stuffy or runny nose), red/watery eyes, digestive disturbances and diarrhea. Less common signs include racing heart, chest pain, headache and dizziness.. ...
This is a non-interventional multi-center study (NIS) in adult patients with AML in first complete remission with measurable minimal residual disease (MRD). Patients are eligible when gene status was already determined for previous induction and consolidation therapy of AML and showed carrier of NPM1, CBFβ-MYH11, or MLL-AF9 mutation. The study objective is to observe the impact of pre-emptive therapy with histamine dihydrochloride (HDC) and interleukin-2 (IL-2) with regard to assess leukemia-free survival/time to relapse and to monitor MRD level trend over time. HDC and IL-2 are approved drugs for AML patients in first complete remission. Therapy is administered for 10 treatment cycles as outlined in the Summary of Product Characteristics ...
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It was recently reported that caffeine may reduce the clinical symptoms of asthma and may prevent the clinical manifestations of this disease. The effect of caffeine on histamine responsiveness is unknown. The effect of caffeine (5 mg/kg) and placebo on histamine responsiveness (the provocation concentration causing a 20% fall in FEV1, PC20) was studied in 10 subjects with mild asthma (prechallenge FEV1 84% of predicted value). The PC20 for histamine bronchoprovocation after caffeine ingestion was 2.65 (95% confidence limits 0.99, 7.10) mg/ml. After placebo the PC20 was 1.89 (0.96, 3.71) mg/ml. It is concluded that caffeine in a dose equivalent to about three cups of coffee has a very small effect, if any, on histamine bronchoprovocation in those with mild asthma. Specific instructions about not having drinks containing caffeine before histamine challenge are therefore not necessary.. ...
Histamine. Its an important neurotransmitter found in the brain, in the gut, and even in the food we eat. Commonly associated with allergy, theres more to histamine than meets the eye. In this episode of the podcast, we get into all things histamine and histamine intolerance. We discuss the genes that play an important role in clearing histamine from the body, the link between histamine intolerance and leaky gut, how to determine whether your histamine levels have gotten too high, supplements to consider for quieting down the immune system and keeping histamine in check, and whether low histamine diets are sustainable. You can view my histamine intolerance blog here and the American Journal of Clinical Nutrition article referenced in the podcast episode here.. ...
Pharmacological studies in mammals and zebrafish suggest that histamine plays an important role in promoting arousal. However, genetic studies using rodents with disrupted histamine synthesis or signaling have revealed only subtle or no sleep/wake phenotypes. Studies of histamine function in mammalian arousal are complicated by its production in cells of the immune system and its roles in humoral and cellular immunity, which can have profound effects on sleep/wake states. To avoid this potential confound, we used genetics to explore the role of histamine in regulating sleep in zebrafish, a diurnal vertebrate in which histamine production is restricted to neurons in the brain. Similar to rodent genetic studies, we found that zebrafish that lack histamine due to mutation of histidine decarboxylase (hdc) exhibit largely normal sleep/wake behaviors. Zebrafish containing predicted null mutations in several histamine receptors also lack robust sleep/wake phenotypes, although we are unable to verify ...
TY - JOUR. T1 - Determination of histamine content in vegetable juices by using direct and competitive immunosensors. AU - Adányi, Nóra. AU - Székács, Inna. AU - Szendro, István. AU - Székács, András. PY - 2014/1/1. Y1 - 2014/1/1. N2 - An Optical Waveguide Lightmode Spectroscopy (OWLS)-based immunosensor was developed for selective and sensitive determination of histamine content in fermented vegetable juices. The conjugate of the antigen (histamine-bovine serum albumin 10 μg mL-1) was attached on the amino modified sensor surface with glutaraldehyde. During the measurement standard solutions or samples were mixed with antibodies of appropriate concentration (1:1000), the mixture was incubated for 1 minute and injected into the OWLS system. The amount of antibodies bound to immobilised antigen conjugates was inversely proportional to the histamine content. Relative substrate specificity of the antibody was studied, and besides histamine, only putrescine, cadaverine and agmatine were ...
This book introduces a novel concept to reduce histamine in food that would benefit both food processors and food consumers. Histamine oxidizing bacteria and enzymes were utilized to degrade preformed histamine, as an emerging approach. This is the first time that an enzyme has been used to reduce histamine in food for human consumption. The histamine oxidizing enzyme was found to completely degrade histamine in tuna soup used to produce Rihaakuru, which is a nutritious and shelf-stable, cooked fish paste of the Maldives, consumed as a side dish. It is generally produced from poor quality fish therefore presence of biogenic amines is suspected. Rihaakuru was found to contain ten different biogenic amines, with histamine in excess of 500 ppm. This may cause histamine poisoning with symptoms such as skin rashes, vomiting and fever. Most of the histamine is likely to be produced by bacteria in raw fish. These bacteria are likely to die during the production of Rihaakuru, however, the histamine ...
Hello arek, You don?t tell why you have a high histamine. Histamine levels can become elevated for many reasons,and are usually temporary. Anything recommended for lowering your level must be run by your physician. Drug interactions can be problematic and even fatal in persons with an elevated histamine, so please check before attempting to treat yourself. Allergies, surgical procedures, parasitic infections (real parasitic infections such as those contracted from eating raw fish), certain fish and shellfish, fermented foods, wines, salamis, etc. can cause an elevated histamine. ?In humans, histamine ( -imidazole ethylamine) is the most important mediator and is mostly found in the initial phase of an anaphylactic reaction (immediate type allergy). Histamine is produced by the enzymatic decarboxylation of histidine. In the organism, histamine is present in nearly all tissues, and it is mainly ...
Published November 3 2014. Histamine is a chemical which plays a role in the inflammatory process, and also acts as a neurotransmitter. It is produced by certain white blood cells, specifically basophils and mast cells, although a few other cells can produce it as well, such as platelets and microglial cells. Some people have an intolerance to histamine, and as a result can experience symptoms such as itching, redness of the skin, hives, congestion or a runny nose, swelling, low blood pressure, arrhythmia, diarrhea, and other symptoms. In addition to talking about histamine intolerance in this article, Ill also discuss how thyroid conditions can affect the production of histamine, and Ill also talk about the relationship between histamine and autoimmunity.. Id first like to talk briefly about histamine metabolism. Histamine is synthesized from the amino acid histidine. It is dependent on vitamin B6, and so a deficiency in this vitamin can in turn affect the production of histamine. Histamine ...
Low fodmap low histamine recipes. These low histamine recipes are largely compliant with the Swiss Interest Group Histamine Intolerance food compatibility list using food items that score as 0-1 on their scale. Once you move to Autoimmune Paleo Low-FODMAP low histamine low salicylate oxalate or sulphur diets these are all working from a slightly different basis. Low Histamine Spring Roll Stir Fry Also Low Salicylate Low FODMAP Low Lectin Low Oxalate for people with Mast Cell Activation Syndrome and Histamine Intolerance Salicylates and Salicylate Foods What to know when you have Mast Cell Activation Syndrome or Histamine Intolerance. See more ideas about low fodmap recipes fodmap recipes low fodmap diet. Although strawberries are low in histamine content they are thought to trigger release of histamine and should be avoided. Easy to prepare fresh meals. Preheat a skillet to medium-high heat and spray liberally with nonstick cooking spray. I originally posted this roundup on January 13 2020 but ...
Histamine is one type of biogenic amine that occurs in many foods. When we consume food that contains histamine, our gut uses its special enzymes to destroy the histamine before its absorbed into the bloodstream. The enzyme, Diamine Oxidase (DAO), is released into the gastrointestinal tract as the first line of defence against histamine exposure. Histamine intolerance occurs when there isnt enough of these enzymes in the body. The average human can cope with 50 to 100 mg/kg but people with a histamine intolerance react to much lower levels. The reactions can vary from anaphylaxis to mild localised allergic reactions. Around 80% of people with histamine intolerances are women. Estrogen and histamine can increase histamine levels and vice versa. Histamine sensitivity is difficult to diagnose because a food can cause symptoms one day and no symptoms another. Common symptoms include heachaches, migraines, nasal congestion, hives, fatigue, nausea and vomiting. Some drugs including opioids, muscle ...
We have known about histamine receptors in the heart for many years (1). The human H1- and H2-histamine receptors were cloned and characterized in the early 1990s (2,3), followed closely by the human H3- and H4-histamine receptors several years later (4,5). Histamine is a natural body constituent that is found throughout the body, especially the central nervous system, mast cells, gastric mucosa parietal cells, and basophils. The H1-receptor is coupled to Gα-q11 and activates a number of intracellular signals, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate. In the heart, histamine decreases atrioventricular node conduction time via H1-receptors. The H2-histamine receptors are also found in the heart, and couple to Gαs proteins to signal through cAMP to produce chronotropic and inotropic activity. The H2-histamine receptors also subserve hypotension, flushing, headache, increased gastric acid production, and enhanced vascular permeability. Therefore, in ...
As you are navigating the world of histamine intolerance and mast cell activation disorder, you will come across the term histamine bucket or histamine cup often. What do these terms reference?. From Chris Kresser:. Histamine intolerance is unlike other food allergies or sensitivities in that the response is cumulative, not immediate. Imagine it like a cup of water. When the cup is very full (high amounts of histamine in the diet), even a drop of additional water will cause the cup to overflow (symptoms activated). But when the cup is less full, it would take more water (histamine) to cause a response. This makes histamine intolerance tricky to recognise.. Food, hormones, environment, weather, medications, and stress all serve to fill up the histamine bucket.. So how knowing this useful? If you know your histamine bucket is going to be overflowing, perhaps from a range of factors such as weather (allergy season), timing of your cycle, stress or exposure to other triggers (such as chemicals ...
Biogenic amines, more generally called histamines are chemicals made by our digestive and immune systems. They are also naturally found in many foods and fermented beverages. The histamines in our bodies provide important benefits such as fighting infections and regulating sleep. The histamines found in foods and beverages are surprisingly common. They are especially prevalent in food/drink that is aged or fermented, such as cured meats, aged cheeses or fermented beer, ale and wine. These consumable histamines can trigger allergy-like responses that are unmistakable to the sufferer. As is true with most food intolerances, some people are more sensitive to histamines than others and need to incorporate low histamine diets into their lifestyle.. In the case of wine, histamine precursors are found in the proteins that are in the skin of grapes. The histamines are formed when the juices produced from the grapes are fermented. As a rule of thumb, the thicker the skin and the darker the wine grape - ...
H2 receptors are positively coupled to adenylate cyclase via Gs. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. PKA functions to phosphorylate certain proteins, affecting their activity. The drug betazole is an example of a histamine H2 receptor agonist. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The histamine receptor H2 belongs to the rhodopsin-like family of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Histamine H2 receptors are expressed in the following tissues: Peripheral tissues Gastric parietal cells (oxyntic cells) Vascular smooth muscle Neutrophils Mast cells Heart Uterus Central nervous system ...
There are discrepancies on the criteria that helps consider food rich in histamine or not.. Some authors suggest eliminating from diet those foods with concentrations higher than 20 mg/kg, while other authors are more demanding and consider low histamine foods those with quantities below 1mg/kg. What is clear, however, is that the symptomatic dose is much lower in histaminosis than in toxicity, 15-20mg and 150mg respectively, since the tolerable dose in both cases is 100mg/kg.. Traditionally, research on histamine contents had been focused on foods related to histamine poisoning episodes, such as oily fish, but this is a mistake since its mechanism of rising histamine levels is different. They are sporadic outbreaks which affect general population as a result of unsanitary food effects.. Even so, in Europe there are some initiatives (ALBA, Allergen dataBAnk; TNO Nutrition & Food Research) that seek to provide an exhaustive database about histamine contents in food, due to the decarboxylation of ...
Histamine is a neurotransmitter involved in a number of physiological and neuronal functions. In mammals, such as humans and rodents, the histaminergic neurons found in the tuberomamillary nucleus (TMN) project widely throughout the central nervous system (CNS). Histamine acts as positive modulator of GABA(A) receptors (GABA(A)Rs) and, in high concentrations (10 mM), as negative modulator of the strychnine-sensitive glycine receptor. However, the exact molecular mechanisms by which histamine acts on GABA(A)Rs are unknown. In our study, we aimed to identify amino acids potentially involved in the modulatory effect of histamine on GABA(A)Rs. We expressed GABA(A)Rs with 12 different point mutations in Xenopus laevis oocytes and characterized the effect of histamine on GABA-induced currents using the two-electrode voltage clamp technique. Our data demonstrate that the amino acid residues ß2(N265) and ß2(M286), which are important for modulation by propofol, are not involved in the action of
1. The effect of intra-arterial histamine on fingertip blood flow (FBF) and vascular resistance (FVR) was studied in normal subjects during reflex sympathetic vascoconstriction induced by body cooling and vasoconstriction caused by intra-arterial noradrenaline.. 2. In a room at 20°C, FBF increased from 15.3 ± 35.5 (sd) to 28.3 ± 55.9 ml min−1 100 ml−1 of tissue and FVR decreased from 23.7 ± 17.7 to 11.9 ± 9.9 mmHg·min−1 100 ml−1 (P , 0.01) during infusions of histamine (0.5-4 μg/min) in 14 subjects. In nine of these subjects, the disappearance half times of local injections of Na131I were measured and decreased from 19.8 ± 10.9 to 12.9 ± 7.3 min during histamine infusions, indicating an increase in nutritional flow. Arteriovenous shunt flow was also probably affected, for increases in FBF were sometimes large and FBF increased without a change in the radioisotope half time in two subjects.. 3. Neither cimetidine nor pyrilamine (mepyramine) consistently prevented the FBF ...
A dihydrochloride salt form of histamine, Ceplene®, is being developed by Immune Pharmaceuticals Inc (formerly, known as EpiCept Corporation) for the
How Mast Cells and Histamines Can Confuse Your Immune System Lately, prospective clients call the Healing Place looking for help to address various health issues including digestive problems, eczema, fatigue and brain fog. These health issues could be the result of dysfunctional mast cells. I can hear people saying,
The potential for itch production in human skin of the synthetic analogues of histamine, 2-methyl histamine (an H1-receptor agonist) and 4-methyl histamine and dimaprit (H2-receptor agonists) has been studied in vivo and compared with histamine. Itch thresholds for 2-methyl histamine were consistent …
TY - JOUR. T1 - Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes. AU - Osna, Natalia. AU - Elliott, Kathleen. AU - Khan, Manzoor M.. PY - 2001/3/15. Y1 - 2001/3/15. N2 - Interleukin-10 is a potent suppressive factor that down-regulates cellular immune response via inhibition of the production of TH1 cytokines. Histamine shifts the TH1/TH2 balance from TH1 to TH2 cytokines making the effects of histamine on IL-10 secretion an important factor in this switch. This study was designed to assess the role of histamine in the regulation of IL-10 production and the involvement of PKA and STAT factors in this process. TH2 cells (D10.G4.1) and AKR/j splenocytes were pretreated with histamine at a concentration range of 10-8-10-5 M for 1 h and then activated with PMA + ionomycin or anti-CD3 for 24 h. The supernatants were collected and tested for IL-10 content by ELISA. Histamine stimulated IL-10 production in TH2 cells in a dose-dependent manner that was reversed by both ...
So here are some of the strains that my wonderful research scientist friend Katerina has found that are particularly beneficial for both histamine intolerance and leaky gut/intestinal permeability:. Lactobacillus rhamnosus 19070-2. L reuteri DSM 12246. bifidobacteria infantis (B. infantis) 35624. Additionally, quercetin has been shown to be a very effective gut barrier fixer thanks to it stopping mast cells found in the area from leaking histamine and other inflammatory agents.. --REFERENCES--. Bjarnason, Ingvar. Faculty of 1000 evaluation for Intestinal permeability in patients with adverse reactions to food. F1000 - Post-publication peer review of the biomedical literature (n.d.): n. pag. Web.. 7 Signs and Symptoms You Have Leaky Gut. Dr. Axe. N.p., 24 Feb. 2017. Web. 24 Feb. 2017.. Potts, Rashaun A., Caitlin M. Tiffany, Nazzy Pakpour, Kristen L. Lokken, Connor R. Tiffany, Kong Cheung, Renée M. Tsolis, and Shirley Luckhart. Mast cells and histamine alter intestinal permeability during ...
TY - JOUR. T1 - Effects of histamine on dentate granule cells in vitro. AU - Greene, R. W.. AU - Haas, H. L.. PY - 1990. Y1 - 1990. N2 - Hippocampal slices from rat brain were exposed to histamine and related substances in a perfusion chamber. Granule cells of the dentate gyrus were studied with conventional extra- and intracellular recording and a single electrode voltage clamp. Histamine caused, through activation of H2-receptors, a small depolarization, an increase in the number of synaptic and action potentials, a block of the long lasting (but not the early) component of spike afterhyperpolarizations and a reduction of the accommodation of action potential firing. These effects were mimicked by forskolin (suggests activation of adenylate cyclase). In voltage clamp, histamine blocked a long lasting calcium-dependent outward tail current without any reduction of inward current. Thus histamine selectively blocks the late calcium-dependent potassium current in dentate granule cells which ...
The present study examined the effect of histamine H2-receptor antagonists and exogenous histamine on growth of malignant melanoma implant in mice. Drugs were administered to B16BL6 malignant-melanoma-implanted syngeneic mice, and the tumor volume was measured throughout the experiments. Cell proliferation was assessed by MTT assay and mRNA expression was determined by RT-PCR. Both roxatidine and cimetidine significantly suppressed growth of B16BL6 implant compared with vehicle. On the other hand, systemically administered histamine significantly stimulated growth of B16BL6 implants. In addition, the histamine-stimulated B16BL6 implant growth was markedly suppressed by co-administration of cimetidine in a dose-dependent manner. H2-receptor antagonists, however, failed to affect in vitro proliferation of B16BL6 cells. H2-receptor mRNA was detected in B16BL6 implants but not in the cell line. These results indicated that both endogenous and exogenous histamine have ability to stimulate growth of malignant
Histamines cause swollen ankles - What may cause swollen ankles? A few things. Excess dietary sodium can cause fluid retention, which can explain swelling in the foot, ankles and legs. Prolonged sitting or standing in place may cause swelling. It can also be due to other medical issues as well: congestive heart disease, htn, diabetes, uremia and many other issues. Discuss this with your doctor.
TY - JOUR. T1 - Histamine utilizes JAK-STAT pathway in regulating cytokine production. AU - Osna, Natalia. AU - Elliott, Kathleen. AU - Chaika, Oleg. AU - Patterson, Eric. AU - Lewis, Robert E.. AU - Khan, Manzoor M.. PY - 2001/3/22. Y1 - 2001/3/22. N2 - Histamine shifts TH1/TH2 cytokine balance from TH1 to TH2 cytokines. The phosphorylation of STAT factors and their translocation to nucleus are important steps in the regulation of TH1/TH2 cytokine balance. This study was designed to investigate the effects of histamine on Janus kinases-signal transducers and activators of transcription (JAK-STAT) pathway. The splenocytes were treated with histamine in the presence or absence of JAK-STAT inhibitor, tyrphostin, activated with IFNγ for 30 min, and phosphorylated STAT1 was detected by immunoblotting. We found that histamine up-regulated the phosphorylation of STAT1 and tyrphostin prevented this phosphorylation. We then studied the effects of tyrphostin on histamine-mediated inhibition of IFNγ ...
The effects of compound 48/80, adenosine-5-triphosphate (ATP) and exogenous histamine (Hi) on the healing of excised surface wound and tensile strength of surgical skin wound in rat were studied. The...
If a patient is seen shortly after an episode, plasma histamine or urinary histamine metabolites, or serum tryptase measurements may be helpful in confirming the diagnosis.{ref2} Plasma histamine leve... more
Histamine receptors provide feedback inhibition for the synthesis and release of histamine from the hypothalamus, as well as inhibition of other neurotransmitters, such as acetylcholine from intestinal cholinergic nerves, and norepinephrines from the retina and cerebral cortex. Our previous results suggest that the regulation of histamine release by histamine H3 receptors changes with the progression of hypertension in Spontaneously Hypertensive Rats (SHR). Therefore, we believe that the histamine H3 receptor plays a role in the promotion and sustained development of hypertension. Analysis of saturation binding data from Spontaneously Hypertensive Rat cerebral cortex indicate that as animals aged from six to sixteen weeks the maximal number of receptor sites (Bmax) increased whereas the affinity of [3H]-N-a-methylhistamine for these sites decreased. B max was 38 + 1.58, 59.63 + 2.48, 79.17 + 5.02, and 84.41 + 3.72 fmol/mg of protein at six, nine, twelve, and sixteen weeks, respectively. High performance
Follow a lower histamine diet. This is job one: stop filling up the bucket. This diet is restrictive, Im not going to lie but the good news is that if you suspect histamine issues and you avoid it for even just two weeks you will start to see improvement. Get my Histamine Avoidance Diet Handout right here.. A ketogenic diet may be an option too. Learn more about that on this recent podcast with Mike Mutzel, MS. I find most people do well following my Histamine Avoidance Diet but if youre still struggling you can also keto or at least limiting protein intake and opting for more fat (remember protein contains histidine which converts to histamine).. Heal your gut. Start with a good rotation of probiotics but avoid any that are made via fermentation such as soil based probiotics which are normally great dont work as well when you have histamine issues. These include Garden of Life Primal Defense, Prescript Assist or Megaspore.. Consider a gut healing product that lessens inflammation and ...
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Semantic Scholar extracted view of [The blood gastrin curve after histamine stimulation and a protein meal in common diseases of the digestive tract]. by Francesco Di Mario et al.
After the last post, a reader sent me some articles showing the relationship between TNF-Alpha and Histamines. Earlier on this blog, I have discussed the possibility of some CFS patients having histamine sensitivity. It turns out that reducing histamines may increase the inflammatory response :-(. Things are never simple - unfortunately. These results suggest that…
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose ...
[Studies with experimental bronchospasm (histamine provocation test) for determination of the efficacy of an antihistaminic]. - H M Beumer
Histamine causes massive inflammation in the body. Rather than just blocking the receptors with antihistamines, we need to give the body ammunition to help it deal with it. Why do you use X food? Dont you know its high in histamine?:: I get a lot of emails asking why my books include this or that food - after all, dont I realise its high histamine? Were usually speaking of chickpeas, bananas, sunflower seeds or blueberries, rather than burgers, spaghetti, whatever. Thats because in my cookbooks you will never, ever, find junk food or any medium/high histamine food thats nutritionally null. Interestingly I am often asked this question by people who still feel its OK for them to indulge in pizza (no tomato though!), or the infrequent Taco Bell; those who still drink coffee or black tea (with just one spoon of sugar!), or who restrain themselves to only licking off the frosting when baking cupcakes for the family. Present them with the idea of eating a banana though, and they run a ...
1. In bovine coronary arteries, cholinesterase staining showed an extensive cholinergic innervation at the adventitia-media junction, and some cholinesterase in the outer but not inner smooth muscle.2. Acetylcholine or methacholine caused large, atropine-sensitive contractions of outer muscle but caused little contraction of inner muscle.3. Fluorescence microscopy for monoamines and for histamine, supported by chemical assays, showed no adrenergic innervation but showed numerous fluorescent cells in the adventitia and the outer 50% of the media which stained as mast cells and contained large amounts of histamine and noradrenaline and some dopamine, but little 5-hydroxytryptamine (5-HT).4. 5-hydroxytryptamine (acting by D receptors) and histamine (acting by H(1) receptors) in high concentrations caused large contractions, of similar size, in inner and outer muscle. In given submaximal concentrations they generally caused more contraction of outer than inner muscle, particularly in the case of histamine,
1. The specificity of intracellular Ca2+ stores to Ca2+-mobilizing agonists was studied in DDT1 MF-2 vas deferens cells of the Syrian hamster.. 2. Application of histamine (100-mu-M or ATP (100-mu-m) to the DDT, MF-2 cells caused an initial increase of intracellular Ca2+ followed by a lower phase as measured by using Indo-1 as fluorescent probe at 22-degrees-C. The basal Ca2+ level (146 nM) was enhanced to 309 nm by histamine and to 379 nM by ATP.. 3. A transient rise in intracellular Ca2+ lasting for about 2 min was measured in the presence of histamine or ATP in the absence of extracellular Ca2+. The basal Ca2+ level (78 nm) was increased to 128 nm by histamine and to 145 nm by ATP.. 4. A transient hyperpolarization was elicited in single cells as measured with microelectrodes by both agonists under Ca2+-free conditions with a similar time course as the change in internal Ca2+ . The hyperpolarization observed in the presence of histamine amounted to 23 mV and 31 mV with ATP. The ...
If youve ever dealt with seasonal allergies, or you happen to have a serious food allergy, then youve likely heard the term histamine in one context or another. While histamine is directly related to allergic reactions, its technically a chemical in your immune system which cause an immediate inflammatory response after coming in contact with any food or drink item that your body deems a potential health threat.. It works a bit like this: imagine a peanut allergy. When you eat a peanut, histamine automatically inflames your blood vessels. This lets your body know it needs to send as many white blood cells - the kinds that attack infection - to the affected areas as possible. However, too much histamine sent at once can obviously cause a severe allergic reaction that, if not treated quickly, can cause anaphylaxis.. However, its also possible to have too much histamine present in your immune system - even if youre not allergic to any food or dont have seasonal allergies. Its also possible ...
The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. Histamine has two ... Histamine intolerance Histamine receptor antagonist Scombroid food poisoning Photic sneeze reflex Histamine Material Safety ... Sake contains histamine in the 20-40 mg/L range; wines contain it in the 2-10 mg/L range. Most histamine in the body is ... In humans, histamine exerts its effects primarily by binding to G protein-coupled histamine receptors, designated H1 through H4 ...
Holger Stark: Histamine Receptors, BIOTREND Reviews No. 01, November 2007 The Histamine Receptor Histamine+Receptor at the US ... The histamine receptors are a class of G protein-coupled receptors which bind histamine as their primary endogenous ligand. ... "Histamine Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ... There are four known histamine receptors: H1 receptor H2 receptor H3 receptor H4 receptor There are several splice variants of ...
... are substances that contain low amounts of histamine themselves but are capable of releasing histamine ... Some histamine liberators were thought to be organic bases as they are synonymous with histamine since it is a base as well, ... However, other histamine-liberating substances, such as decylamine, manifested a steady increase in histamine activity with ... The crux of this theory lies in the assumption that histamine liberators release histamine by displacing it from cells. The ...
... , sometimes called histaminosis, is an over-accumulation of dietary histamine in the human body. Histamine ... because they are known to release histamine stored in the body (histamine liberation). If eating histamine-containing foods is ... The imbalance in histamine intolerance is between the synthesis and selective release of histamine from certain granulocytes (i ... At the same time, the histamine blood level halves and the DAO increases significantly. If there is no histamine intolerance, ...
... (INN, trade name Ceplene) is a salt of histamine that is used as a drug for the prevention of relapse ... The combination of histamine dihydrochloride and interleukin-2 was approved for use in AML patients within the European Union ... Histamine dihydrochloride is administered in conjunction with low doses of the immune-activating cytokine interleukin-2 (IL-2) ... Histamine dihydrochloride has been developed by researchers at the University of Gothenburg, Sweden. Federal Register, volume ...
A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes. H2: ... Histamine antagonist Histamine+agonist at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of ... H3: Betahistine is a weak Histamine1 agonist and a very strong Histamine3 antagonist (paradoxically histamine increasing). ... Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine. ...
Histamine receptor antagonists H1-receptor antagonist Histamine H2-receptor Histamine H3-receptor Histamine H4-receptor GRCh38 ... Histamine H1 receptors are activated by endogenous histamine, which is released by neurons that have their cell bodies in the ... While the best characterized function of the histamine system in the brain is regulation of sleep and arousal, histamine is ... Horváth BV, Szalai C, Mándi Y, László V, Radvány Z, Darvas Z, Falus A (Nov 1999). "Histamine and histamine-receptor antagonists ...
... histamine receptor antagonists H3-receptor antagonist Histamine H1-receptor Histamine H2-receptor Histamine H4-receptor GRCh38 ... "Histamine and Histamine Receptors in Tourette Syndrome and Other Neuropsychiatric Conditions." Neuropharmacology 106 (July 2016 ... Mouse-models and other research demonstrated that reducing histamine concentration in the H3R causes tics, but adding histamine ... Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where ...
Inhibition of neutrophil activation and chemotaxis H2-receptor antagonist Histamine H1-receptor Histamine H3-receptor Histamine ... Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The histamine receptor H2 belongs to the rhodopsin- ... The drug betazole is an example of a histamine H2 receptor agonist. Histamine is a ubiquitous messenger molecule released from ... Classification of histamine receptors". Pharmacological Reviews. 49 (3): 253-78. PMID 9311023. "Entrez Gene: HRH2 histamine ...
... (HNMT, HMT) is an enzyme involved in the metabolism of histamine. It is one of two enzymes ... In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative ... Methylated histamine metabolites are excreted with urine. In mammals, histamine is metabolized by two major pathways: oxidative ... Although the relationship between histamine and IL-8 has not been fully studied as of 2020[update], it is known that histamine ...
Histamine H1-receptor Histamine H2-receptor Histamine H3-receptor GRCh38: Ensembl release 89: ENSG00000134489 - Ensembl, May ... The histamine H4 receptor, like the other three histamine receptors, is a member of the G protein-coupled receptor superfamily ... "Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor". Mol. Pharmacol. ... Unlike the histamine receptors discovered earlier, H4 was found in 2000 through a search of the human genomic DNA data base. H4 ...
... (HTFMT) is a mixed H1/H2 histamine agonist which is significantly more potent than ... Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. Journal of ... It also produces additional actions which appear to be independent of histamine receptors. Whyment AD, Blanks AM, Lee K, Renaud ... Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of ...
Histamines are proteins associated with many allergic reactions. When the UV radiation or light comes in contact with a person ... "Histamine". Davidson College. 2000. Retrieved 2008-11-01. Taranova, NP (1975). "[Effect of whole-body x-irradiation on the ... When this occurs, the permeability of vessels near the area of histamine release is increased. This allows blood fluid to enter ... Antihistamines suppress the activity of the histamine. Diphenhydramine, a first-generation H1 receptor antagonist or medicine ...
Hamlin, K. E.; Weston, Arthur W.; Fischer, Francis E.; Michaels, R. J. (1949). "Histamine Antagonists. II.1Unsymmetrical 1,4- ... N-METHYL-N'-BENZHYDRYLPIPERAZINES AS HISTAMINE ANTAGONISTS1". The Journal of Organic Chemistry. 14 (5): 775-782. doi:10.1021/ ...
Histamine alkaloids. Acacia sophorae, Tryptamine in leaves, bark Acacia macradenia, Tryptamine Acacia maidenii, 0.6% NMT and ...
... are a class of medications that block the action of histamine at the histamine H2 receptors of the parietal cells in the ... Ranitidine was also the result of a rational drug design process utilising the by-then-fairly-refined model of the histamine H2 ... They designated the one acted upon by the traditional antihistamines as H1, and the one acted upon by histamine to stimulate ... The SK&F team used a classical design process starting from the structure of histamine. Hundreds of modified compounds were ...
Histamine also promotes angiogenesis. Antihistamines suppress the histamine-induced wheal response (swelling) and flare ... by blocking the binding of histamine to its receptors or reducing histamine receptor activity on nerves, vascular smooth muscle ... which modulate the release of histamine. Histamine release in the brain triggers secondary release of excitatory ... Normally, histamine acts on H2 to stimulate acid secretion; drugs that inhibit H2 signaling thus reduce the secretion of ...
Maintz L, Novak N (2007). "Histamine and histamine intolerance". Am J Clin Nutr. 85 (5): 1185-96. doi:10.1093/ajcn/85.5.1185. ... Food allergies are immune reactions, typically an IgE reaction caused by the release of histamine but also encompassing non-IgE ... Maintz L, Benfadal S, Allam JP, Hagemann T, Fimmers R, Novak N (May 2006). "Evidence for a reduced histamine degradation ... Götz M (1996). "[Pseudo-allergies are due to histamine intolerance]". Wien Med Wochenschr (in German). 146 (15): 426-30. PMID ...
By reversing the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms. It also crosses the ... Histamine, Bradykinin, and Their Antagonists". In Brunton L (ed.). Goodman & Gilman's The Pharmacological Basis of Therapeutics ... Krystal AD, Richelson E, Roth T (August 2013). "Review of the histamine system and the clinical effects of H1 antagonists: ... Ghoneim OM, Legere JA, Golbraikh A, Tropsha A, Booth RG (October 2006). "Novel ligands for the human histamine H1 receptor: ...
... anti-histamine); Atovaquone (PCP/Malaria); Exosurf (infant respiratory distress); Mivacron and Nuromax (neuromuscular blockade ...
Histaminergic neurons-histamine. Histamine is a monoamine neurotransmitter and neuromodulator. Histamine-producing neurons are ... Histamine is involved in arousal and regulating sleep/wake behaviors. Since 2012 there has been a push from the cellular and ... Scammell TE, Jackson AC, Franks NP, Wisden W, Dauvilliers Y (January 2019). "Histamine: neural circuits and new medications". ...
Before the test each subject was given an antihistamine which blocked all of the effects of histamine apart from its effect on ... His paper describing this test, Effect of Large Doses of Histamine on Gastric Secretion of HCl, became the single most cited ... He developed the augmented histamine test, which bore his name, and was widely used in the investigation and treatment of ... Kay used increasing doses of histamine to stimulate acid production and found that acid production was higher in patients with ...
... and histamine N-methyltransferase (HNMT), which methylates histamine in the process of histamine metabolism. Catechol-O- ... "HNMT histamine N-methyltransferase". NCBI Genetic Testing Registry. Retrieved 18 February 2014. "COMT catechol-O- ...
Rapanelli M, Pittenger C (July 2016). "Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric ... Histamine and the H3 receptor may play a role in the alterations of neural circuitry. A reduced level of histamine in the H3 ... Sadek B, Saad A, Sadeq A, Jalal F, Stark H (October 2016). "Histamine H3 receptor as a potential target for cognitive symptoms ... Rapanelli M (February 2017). "The magnificent two: histamine and the H3 receptor as key modulators of striatal circuitry". Prog ...
Maintz, Laura; Novak, N (May 2007). "Histamine and histamine intolerance". The American Journal of Clinical Nutrition. 85 (5): ... alcohol consumption may lead to elevated plasma histamine levels even in the absence of histamines in the beverage consumed. A ... Histamine is present in a variety of fermented products such as wine, aged cheeses, and sauerkraut. Red wine has 20-200% more ... Alcohol flush reaction Browning in red wine Food intolerance Headache Histamine intolerance Wine and health Wine fault K. ...
For example, histamine is biosynthesised strictly via the enzyme histidine decarboxylase in humans and other organisms. In ... Huang H, Li Y, Liang J, Finkelman FD (2018). "Molecular Regulation of Histamine Synthesis". Frontiers in Immunology. 9: 1392. ... chikawa A, Tanaka S (2012). "Histamine Biosynthesis and Function". eLS. American Cancer Society. doi:10.1002/9780470015902. ... a trace amine neuromodulator L-Histidine to histamine - a neurotransmitter L-Tryptophan to tryptamine - a trace amine ...
R. Bowen (2008). "Histamine and Histamine Receptors". "Excitotoxicity and Cell Damage". 2010. M. Aarts; M. Tymianski (2003-09- ... Histamine acts as an excitatory neurotransmitter by binding G-protein coupled receptors in neurons of the hypothalamus. These ... Of the four types of histamine receptors (H1 - H4), H3 is found in the central nervous system and is responsible for regulating ... histamine effects on neurotransmission. Excitatory synapses have a fundamental role in information processing within the brain ...
"Histamine: Friend or Foe? , House Online Neurotology Education Program." YouTube, YouTube, 19 May 2021, ...
Ganellin, C. R.; Parsons, M. E. (1982). Pharmacology of Histamine Receptors. Butterworth-Heinemann. ISBN 978-0-7236-0589-8. " ...
Patients were given injections of histamine of increasing strength for up to 24 days. The treatment caused their blood pressure ... Some patients received combination treatments of histamine coupled with insulin or ECT. Sackler and his wife Else began ... S2CID 35613071.{{cite journal}}: CS1 maint: multiple names: authors list (link) Lucy, John D. (1954). "Histamine Tolerance in ... "The Technique of Histamine Biochemo-therapy and Suggestions for its Use in Psychiatry". The Journal of Nervous and Mental ...
The histamine response can produce sneezing, itching, hives and watery eyes. ... Mast cells release histamine when an allergen is encountered. ... Mast cells release histamine when an allergen is encountered. ...
Histamine H2-Receptor Antagonists. Class Summary. These agents are usually given in addition to H1 blockers. ... This agent inhibits histamine at H2 receptors of gastric parietal cells, which results in reduced gastric acid secretion, ... Fexofenadine competes with histamine for H1 receptors in the GI tract, blood vessels, and respiratory tract, reducing ... Famotidine competitively inhibits histamine at the H2 receptors in gastric parietal cells, reducing gastric acid secretion, ...
Histamine in Salmonids: joint FAO/WHO literature review  World Health Organization; Food and Agriculture Organization of the ... Joint FAO/WHO expert meeting on the public health risks of histamine and other biogenic amines from fish and fishery products: ... Histamine poisoning associated with fish, cheese, and other foods / by Steve L. Taylor  ...
In this podcast DrA will answer questions around histamine pathology and management and those questions that followed the ... ...
... - The Environmental Illness Resource , Information & Community ... Biogenic Amines and Histamine Intolerance Featured When thinking about how food sensitivities and/or intolerances may be ... The most well known biogenic amines are the neurotransmitters serotonin, dopamine, and noradrenaline, and histamine, best known ... such as the inflammation produced by histamine release), or regulate functions of the gut. The classic neurotransmitters ...
Histamine H2 antagonists. Class Summary. This class is for the symptomatic relief of reflux resulting from esophageal ... Ranitidine inhibits histamine stimulation of the H2 receptor in gastric parietal cells, which, in turn, reduces gastric acid ... Nizatidine competitively inhibits histamine at the H2 receptor of the gastric parietal cells, resulting in reduced gastric acid ... Famotidine competitively inhibits histamine at the H2 receptor of gastric parietal cells, resulting in reduced gastric acid ...
Histamine dihydrochloride , C5H11Cl2N3 , CID 5818 - structure, chemical names, physical and chemical properties, classification ...
The full functional implications of pharmacogenetic variation in the activities of catechol O-methyltransferase and histamine N ... Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase ... and histamine N-methyltransferase. In recent years, characterization of these genetic polymorphisms has been extended to ...
Although interest in histamine intolerance has considerably grown in recent years, more scientific evidence is still required ... In this work, a glance on histamine intoxication will also be provided, as well as the analysis of some uncertainties ... This article will provide an updated review on histamine intolerance, mainly focusing on its etiology and the existing ... is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning of the ...
Histamine H2 Antagonists. Class Summary. Cytochrome P-450 inhibitors are recommended only for patients with methemoglobinemia ...
Learn more about high histamine foods that some people choose to avoid. ... Histamine produced in the body is a key mediator in allergic reactions. ... Low-Histamine Diet Some people choose a low-histamine diet. This diet reduces the amount of high-histamine foods and those ... Histamine Intolerance Histamine intolerance is also called food histaminosis and hypersensitivity to food histamine, but it has ...
J:4933 Sudweeks JD, et al., Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune ...
Diagnostic value of the insulin-histamine test in stomach diseases]. Download Prime PubMed App to iPhone, iPad, or Android ... AdultDuodenal UlcerGastric JuiceGastric MucosaGastritisHistamineHumansInsulinMiddle AgedStomach Neoplasms ... Kravets, M G.. "[Diagnostic Value of the Insulin-histamine Test in Stomach Diseases]." Vrachebnoe Delo, vol. 2, 1972, pp. 21-4. ... Kravets, M. G. (1972). [Diagnostic value of the insulin-histamine test in stomach diseases]. Vrachebnoe Delo, 2, 21-4. ...
Low histamine, corn, egg, nightshade, nut, peanut, sesame, soya free; can be gluten, lactose, milk & wheat free ... Low histamine, corn, egg, nightshade, nut, peanut, sesame, soya free; can be gluten, lactose, milk & wheat free ...
... experts discuss the uniqueness of pitolisant as a treatment option within the setting of narcolepsy and the role histamine ... If you cut the brake cable, guess what? Histamine comes out, and the histamine comes out and wakes you up. ... It is pro histamine. Usually I say its histaminergic, but every audience Ive had since I started talking about this hears ... You want to boost histamine in your brain, and you can do that by a couple of different mechanisms. Did you know that the ...
I posted previously about how I think the methylated supplements contributed to my food/med/supp sensitivites. However, I ve recently remembered that just before I expereinced these symptoms I got 3 vaccinations before taking a trip to Brazil earlier this year. It was within just days of getting these vacinnes that my symptoms began, head pressure, food reactions and difficulty breathing. I thought the breathing issue was due to the higher humidity in Brazil. I never suspected the vaccines until recently and instead thought it was the supps b/c I d read they can cause sulfur issues. ...
About Us , Contact Us , Advertise With Us WholeFoods Magazine is the industrys leading resource for health and nutrition articles. We provide important information regarding industry news, research, and trends.. NOTE: WholeFoods Magazine is a business-to-business publication. Information on this site should not be considered medical advice or a way to diagnose or treat any disease or illness. Always seek the advice of a medical professional before making lifestyle changes, including taking a dietary supplement. The opinions expressed by contributors and experts quoted in articles are not necessarily those of the publisher or editors of WholeFoods. ...
Ezeamuzie, C.I. & Philips, E. Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil ... and can be used to inhibit the release of histamine from human basophils and mast cells 60. Histamine may act as an autocrine ... these and other associated lung cells that are positive for histamine receptors H1 and H2 could respond to local histamine ... off-target binding of a non-histamine H2 G-coupled protein receptor 4) histamine H2 receptor inhibition. ...
An introduction to the pharmacology of histamine and its antagonists is presented. ... Clinical Uses: H1 Histamine Receptor Blockers * Allergic Reactions * H1 histamine receptor blockers ... Histamine: Storage and Release * Immunologic Release: The most important mechanism for histamine release is in response to an ... Histamine: Clinical Pharmacology-- Uses * Pulmonary Function: histamine aerosol may be used to test for bronchial ...
The DAO enzyme in our Histamine Reducing Probiotic Powder is responsible for breaking down histamine in the intestines. Our ... Body Ecology Histamine Reducing Probiotic Powder is a blend of beneficial bacteria that support the DAO enzyme and helps to ... Our Histamine Reducing Probiotic Powder breaks down excessive histamine and assists with histamine intolerance and low ... Home / Energy Boosters / Histamine Reducing Probiotic (powder probiotic) Histamine Reducing Probiotic (powder probiotic). ...
Histamine (100 microM) induced a rapid increase in vascular tension in physiologic buffer which rapidly faded or desensitized ... The differences in responsiveness of potassium chloride, histamine, and PGF2 alpha under the various conditions used suggest ... The potential roles of PGF2 alpha, histamine, and calcium channel blockers in modulating the fetoplacental circulation is ... The calcium dependence of potassium chloride-, prostaglandin F2 alpha (PGF2 alpha)-, and histamine-induced contractions of ...
Histamine intolerance is not a sensitivity to histamine, but an indication that youve developed too much of it. Histamine is a ... When histamine levels get too high or when histamine cannot break down properly, it can affect your normal bodily functions.. ... As a neurotransmitter, histamine communicates messages to your brain.. *Histamine is a component of stomach acid that helps to ... Home - Skincare Routine - Self Care - High histamines - do I have a histamine intolerance? ...
Histamine is formed by microbial decarboxylation of histidine. Histidine is an essential amino acid which is present in all ... Histamine may lead to Scombroid food poisoning, which resembles allergic reactions. This method is intended for quantification ... Histamine in fish: Liquid chromatographic determination with post-column derivatization and fluorescence detection. ... Histamine in fish: Liquid chromatographic determination with post-column derivatization and fluorescence detection. ...
GPCR97-Expressing Cells Bind the High-Affinity Histamine H3 LigandR-α-Methyl[3H]histamine.. To confirm the H3 pharmacology, we ... 1983) Autoinhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature (London) 302:832- ... a third subtype of histamine receptor, H3, was identified as a presynaptic autoreceptor on histamine neurons in the brain ... Cloning and Functional Expression of the Human Histamine H3 Receptor. Timothy W. Lovenberg, Barbara L. Roland, Sandy J. Wilson ...
HISTAMINE DIHYDROCHLORIDE (UNII: 3POA0Q644U) (HISTAMINE - UNII:820484N8I3) HISTAMINE DIHYDROCHLORIDE. 8 [hp_X]. ... Label: BHI ALLERGY- antimony trisulfide, arnica montana root, formic acid, graphite, histamine dihydrochloride,strychnos ... BHI ALLERGY- antimony trisulfide, arnica montana root, formic acid, graphite, histamine dihydrochloride,strychnos ignatii seed ... BHI ALLERGY- antimony trisulfide, arnica montana root, formic acid, graphite, histamine dihydrochloride,strychnos ignatii seed ...
Randomized Controlled Study of the Histamine H3 Inverse Agonist MK-0249 in Adult Attention-Deficit/Hyperactivity Disorder. W. ... Background: It has been suggested that the histamine subtype 3 receptor inverse agonists such as MK-0249 might be effective in ...
Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines.. G W Read and E ... Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines.. G W Read and E ... Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines.. G W Read and E ... BAC caused histamine release by itself at concentrations over 5 microgram/ml. Heat inactivation (50 degrees C for 15 min) of ...
Here are tips on how to follow a low histamine diet. ... Histamine intolerance is difficult to diagnose and is often ... Im a little confused, Ive been led to believe broccoli is a low histamine food, although its on the high histamine list on ... If you are experiencing a histamine intolerance, its important to follow a LOW histamine diet for quite awhile until your body ... The tricky thing about histamines is that the reaction to foods is not immediate. Histamine intolerance is also closely linked ...
Histamine and Sir Henry Dale. Br Med J 1965; 1488-90.. 16 Riley JF, West GB. The presence of histamine in tissue mast cells. J ... both the general release of histamine into the blood stream of the dog and the local release of histamine into the skin of the ... You imply that histamine may be carried in the acid granules of the mast cell. This is very curious. You must do some more work ... As for histamine itself, no one yet knew where it was made, how it was stored or by what mechanism it was released. Valuable ...
... a histamine H2-blocking drug, in delaying the progression of cognitive impairment in older adults with Alzheimer disease (AD). ... H2 Histamine Receptor Blockade in the Treatment of Alzheimers Disease: A Randomized, Double-Blind Placebo-Controlled Trial of ... Histamine Receptor Blockade in the Treatment of Alzheimers Disease: A Randomized, Double-Blind Placebo-Controlled Trial of ... Objectives: To evaluate the efficacy of nizatidine, a histamine H2-blocking drug, in delaying the progression of cognitive ...
  • Histamine intolerance, also referred to as enteral histaminosis or sensitivity to dietary histamine, is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning of the 21st century. (
  • Histamine intolerance has never been proven to be a true medical disorder, but some people think that they feel better when they avoid some of these foods. (
  • Vacinations contributed to my histamine intolerance/MCS. (
  • Our Histamine Reducing Probiotic Powder breaks down excessive histamine and assists with histamine intolerance and low histamine. (
  • do I have a histamine intolerance? (
  • Home - Skincare Routine - Self Care - High histamines - do I have a histamine intolerance? (
  • Histamine intolerance is not a sensitivity to histamine, but an indication that you've developed too much of it. (
  • Many Western medicine doctors do not understand the connection between high histamine foods and these symptoms, however if you are experiencing symptoms like the ones listed above, you may be suffering from a common cause of food intolerance and disease, called Histamine Intolerance. (
  • Many people haven't heard of histamine intolerance but it is a food intolerance that's difficult to diagnose and is often confused with many other conditions. (
  • Histamine intolerance is also closely linked to dysbiosis and SIBO (Small Intestinal Bacteria Overgrowth) . (
  • My Integrative doctors believe that the main cause of histamine intolerance is from an overgrowth of bad bacteria int he gut that makes histamine from foods that are not digested. (
  • If you are experiencing a histamine intolerance, it's important to follow a LOW histamine diet for quite awhile until your body is able to tolerate eating histamines again. (
  • A Cup of Coffee - Do You Have A Histamine Intolerance? (
  • This week we are going to talk about Histamine Intolerance. (
  • To date there is no clear cause of histamine intolerance, and the diagnosis is therefore difficult. (
  • Diagnosing histamine intolerance requires a comprehensive physician's review of the patient's lifestyle, nutritional habits, and symptoms. (
  • Since the symptoms are unspecific, other diagnoses should be considered along with histamine intolerance. (
  • If, after other causes have been ruled out, the suspicion of a histamine intolerance still exists, the next step is an elimination diet followed by a provocation test (also known as a histamine challenge). (
  • If the symptoms improve during this time, this provides evidence of histamine intolerance. (
  • If they detect the known symptoms from a certain histamine load, this is considered to be evidence of the histamine intolerance. (
  • Almost a month ago I blogged about Histamine Intolerance, a widespread and under diagnosed condition. (
  • Histamine Intolerance can be used as a frame work to understand the connection between many different symptoms, and to provide an understanding of the way that they are linked by a common underlying pathophysiology. (
  • Histamine intolerance flies beneath the radar of most doctors, and can easily result in a misguided treatment approach. (
  • Histamine Intolerance is a modern day Great Pretender. (
  • I continued to research on the internet, and came upon a site called The Reluctant Raw Foodist , which was written by a woman with severe Histamine Intolerance who had similar symptoms to Sandra. (
  • Prominent psychiatric symptoms can be the presenting complaint of a patient suffering from Histamine Intolerance, with anxiety, panic and insomnia. (
  • When a patient tries to discontinue the drug, symptoms of histamine intolerance can manifest, such as profound insomnia and anxiety, and it can be difficult to come off the medications. (
  • Causes include the possibility of a genetic component, histamine intolerance, and possible food allergies. (
  • Learn the root causes behind this as well as treatment solutions for this and histamine intolerance. (
  • Fexofenadine competes with histamine for H1 receptors in the GI tract, blood vessels, and respiratory tract, reducing hypersensitivity reactions. (
  • Desloratadine is a long-acting tricyclic histamine antagonist selective for H1 receptors. (
  • Famotidine competitively inhibits histamine at the H2 receptors in gastric parietal cells, reducing gastric acid secretion, gastric volume, and hydrogen concentrations. (
  • It's going to be dancing on those postsynaptic H1 receptors-histamine itself, but the drug releases histamine. (
  • Histamine mediates its effects by interacting with receptors. (
  • Histamine regulates neurotransmitter release in the central and peripheral nervous systems through H 3 presynaptic receptors. (
  • In contrast, in humans, expression and distribution of histamine receptors (HR) within the human gastrointestinal tract are unclear. (
  • Drugs that selectively bind to but do not activate HISTAMINE H3 RECEPTORS. (
  • In an attempt to extend recent studies showing that some clinically evaluated histamine H3 receptor (H3R) antagonists possess nanomolar affinity at sigma-1 receptors (σ1R), we selected 20 representative structures among our previously reported H3R ligands to investigate their affinity at σRs. (
  • The so-called antihistamines are H1 postsynaptic antagonists, and you must know that histamine is a neurotransmitter in the brain. (
  • Histamine H3 Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (
  • This graph shows the total number of publications written about "Histamine H3 Antagonists" by people in UAMS Profiles by year, and whether "Histamine H3 Antagonists" was a major or minor topic of these publications. (
  • Below are the most recent publications written about "Histamine H3 Antagonists" by people in Profiles over the past ten years. (
  • Interestingly, both ligands turned out to be high-affinity histamine H3 and σ1 receptor antagonists with negligible affinity at the other histamine receptor subtypes and promising antinociceptive activity in vivo. (
  • Examples include proton pump inhibitors (PPIs) and histamine H2-receptor antagonists (H2 blockers), which are used to reduce acid reflux symptoms and may be available without a prescription. (
  • 15. Anti-histamines (H1-receptor antagonists) (M. Andersen). (
  • As a neurotransmitter, histamine communicates messages to your brain. (
  • Its widespread and abundant neuronal expression in the brain highlights the significance of histamine as a general neurotransmitter modulator. (
  • This undigested food builds up in your body and overwhelms your body- therefore you're left with excess histamine. (
  • Answer: They could all be manifestations of excess histamine in the body. (
  • Transfection of GPCR97 into a variety of cell lines conferred an ability to inhibit forskolin-stimulated cAMP formation in response to histamine, but not to acetylcholine or any other biogenic amine. (
  • Gastric acid secretion is regulated by three primary components that activate the parietal cell: histamine, gastrin, and acetylcholine (ACh). (
  • We investigated how NO derived from the airway nervous system would affect the airway responsiveness to histamine and acetylcholine in mechanically ventilated guinea pigs. (
  • An NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L- NAME) (1 mmol/kg ip) significantly enhanced airway responsiveness to histamine but not to acetylcholine. (
  • Histamine is formed by microbial decarboxylation of histidine. (
  • Histidine decarboxylase (HDC), found in Escherichia coli , Morganella morganii, and in Proteus and Klebsiella species, converts histidine, present in fish tissue, to histamine. (
  • Without adequate cooling, these bacteria multiply, increasing the histidine-to-histamine conversion rate and raising histamine levels. (
  • Toxin production occurs when inadequate refrigeration after the catch allows the multiplication of bacteria that contain histidine decarboxylase, which converts amino acid histidine in the fish tissues to histamine. (
  • Investigation on beneficial role of l-carnosine in neuroprotective mechanism of ischemic postconditioning in mice: possible role of histidine histamine pathway. (
  • The present study was undertaken to investigate the possible role of histidine - histamine pathway in the neuroprotective effects produced by L-carnosine hand in hand with ischemic postconditioning in the animal model of cerebral ischemia . (
  • It is concluded that L-carnosine exerts neuroprotective effect via involvement of histidine - histamine pathway since the beneficial effects of L-carnosine were abolished by the H2-blocker. (
  • Histamine is released after injury or allergic reaction as part of the body's immune response. (
  • Histamine may lead to Scombroid food poisoning, which resembles allergic reactions. (
  • Riley and pharmacologist Dr Geoffrey West went on to galvanise this area of study by showing in a notable series of experiments that the mast cell granules are also the main repository of histamine, a key participant in allergic and anaphylactic reactions. (
  • The authors, led by entomologist Zachary DeVries, conclude that the study's findings are "substantial, because exogenous histamine can provoke allergic responses and asthma. (
  • In the pathogenetic mechanism of allergic asthma, histamine is an independent, as it were, decisive factor involved in the occurrence of an allergic (asthmatic) phenomenon. (
  • In an allergic body, histamine is contained in an abnormally large amount. (
  • In an allergic organism, even an antipectic substance is formed, antipexin, which prevents the capture of histamine from plasma. (
  • Symptoms of histamine fish poisoning resemble an acute allergic reaction and usually appear 10-60 minutes after eating contaminated fish. (
  • The availability of the human H 3 receptor cDNA should greatly aid in the development of chemical and biological reagents, allowing a greater appreciation of the role of histamine in brain function. (
  • In the end, they found that infested apartments averaged 54 micrograms of histamine per 100 milligrams of dust. (
  • Twenty micrograms of histamine acid phosphate was then injected intradermally at 4, 8, 12 and 24 h. (
  • Because solar urticaria involves IgE-mediated mast cell degranulation with consequent histamine release, the first line of treatment for this disease consists of long-acting, nonsedating H1-receptor blockers. (
  • Degranulation means liberation of the contents of the mast cell granules, including histamine. (
  • In these injuries caused degranulation as noted above including again histamine release. (
  • More recently, the role of mast cell degranulation (which releases histamine, among other things) in triggering migraines has come to light and is a topic of increasing research interest. (
  • The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. (
  • This agent competitively inhibits histamine at the H2 receptor of the gastric parietal cells, resulting in reduced gastric acid secretion, gastric volume, and reduced hydrogen concentrations. (
  • Ranitidine inhibits histamine stimulation of the H2 receptor in gastric parietal cells, which, in turn, reduces gastric acid secretion, gastric volume, and hydrogen concentrations. (
  • Under basal conditions, gastrin was shown to be the main regulatory component of the total acid secretion and directly activated the parietal cell rather than by mediating gastric acid secretion through the release of histamine from the enterochromaffin-like cell, although both pathways were active. (
  • The term histamine fish poisoning is now considered more appropriate because many cases are from nonscombroid fish. (
  • Most of the time very little histamine is excreted unchanged because of these metabolic steps. (
  • For two to four weeks, the patient should consume as little histamine as possible and keep a symptom diary. (
  • In contrast, samples of fish that produce poisoning contain histamine levels of at least 20-50 mg per 100 g of fish. (
  • The histamine response can produce sneezing, itching, hives and watery eyes. (
  • When this happens, histamine over activates, producing allergy symptoms like sneezing, itchy and watery eyes, and rashes. (
  • I was diagnosed with having extremely high histamine levels and I blew off the diagnosis because I don't really have allergy symptoms. (
  • When you are exposed to the allergen again, these antibodies release immune system chemicals, such as histamine, that cause allergy symptoms. (
  • Rather than blocking the action of histamine, one of the body's natural chemicals, as a conventional allergy medicine would, this homeopathic remedy works by gently helping our immune system reduce the histamine load on the body without any drowsiness. (
  • The most well known biogenic amines are the neurotransmitters serotonin, dopamine, and noradrenaline, and histamine, best known for its role in allergies. (
  • These biogenic amines may act as neurotransmitters, be involved in local immune responses (such as the inflammation produced by histamine release), or regulate functions of the gut. (
  • Mast cells release histamine when an allergen is encountered. (
  • It's called an H3 receptor, and it's there to be a brake and shut off histamine release. (
  • We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H 2 activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release. (
  • The most important mechanism for histamine release is in response to an immunological stimulus. (
  • Following local injury, histamine first produces a local vasodilation (reddening of the area) followed by an the release of acute inflammation mediators. (
  • Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines. (
  • BAC caused histamine release by itself at concentrations over 5 microgram/ml. (
  • Structure-activity relations studies on various members of the BAC family for their ability to inhibit 48/80-induced histamine release indicated that benzyldimethyltridecylammonium chloride was the most potent. (
  • Histamine release from human leukocytes by anti-gamma E antibodies. (
  • The medication a patient regularly takes can also play a role, as some can cause the body to release its own histamine. (
  • By stabilizing cells that release histamine, it provides anti-inflammatory protection to help resist heart disease and cancer. (
  • Mast Cell Activation syndrome occurs when something causes the mast cells to release abnormal amounts of histamine. (
  • [3] The underlying mechanism involves immunoglobulin E antibodies (IgE), part of the body's immune system, binding to an allergen and then to a receptor on mast cells or basophils where it triggers the release of inflammatory chemicals such as histamine . (
  • The way I understand histamines is like a bucket, you can tolerate so much until the bucket is full and then you begin having symptoms. (
  • A second agent in fish tissues has been theorized to play a role in histamine toxicity because attempts to recreate the symptoms by orally feeding people histamine have failed. (
  • 7 Ten years on, these children are reported to be at least twice as likely to have asthma symptoms as matched controls and have increased incidence of bronchial lability as measured by exercise or histamine challenge tests. (
  • The covalent agonists are derived from the monoamine neurotransmitters noradrenaline, dopamine, serotonin, and histamine, and they were accessed using a general and versatile synthetic strategy. (
  • abstract = "The production of large quantities of the lymphokine(s) histamine-releasing activity (HRA) and its partial purification by Sephadex G-75 and ion-exchange chromatography on carboxymethyl (CM) Sepharose 6B have been detailed (M. A. Lett-Brown, D. O. Thueson, D. E. Plank, M. P. Langford, and J. A. Grant, Cell. (
  • Histamine toxicity is a form of food poisoning called scombroid poisoning that occurs from eating spoiled fish. (
  • Previous terms for histamine fish poisoning were scombroid fish poisoning, pseudoallergic fish poisoning, histamine overdose, or mahi-mahi flush. (
  • Body Ecology Histamine Reducing Probiotic Powder is a blend of beneficial bacteria that support the DAO enzyme and helps to lower high levels of mast cells in the gut. (
  • This comprehensive blend is especially for individuals wanting to optimize effectiveness of a histamine-free probiotic bacteria on their intestinal flora. (
  • Histamine Modulation is associated with the inflammatory responses. (
  • As the creepy critters bite you while you slumber, they also squeeze out poops loaded with histamine, a chemical that our own bodies push out during an inflammatory response to allergens. (
  • Histamine is a potent pro-inflammatory mediator that is principally released from mast cells. (
  • Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. (
  • The DAO enzyme in our Histamine Reducing Probiotic Powder is responsible for breaking down histamine in the intestines. (
  • The enzyme diamine oxidase (DAO) is what breaks down the histamines but in some people, like me, are deficient in it. (
  • Apart from provocation testing, it is possible to measure DAO enzyme activity in the blood, which can affect histamine levels. (
  • Objectives: To evaluate the efficacy of nizatidine, a histamine H2-blocking drug, in delaying the progression of cognitive impairment in older adults with Alzheimer disease (AD). (
  • Alpha 1-adrenergic and H1-histamine receptor control of intracellular Ca2+ in a muscle cell line: the influence of prior agonist exposure on receptor responsiveness. (
  • 5. During the refractory period after methacholine desensitization, muscle strips were still responsive to 40 mM KCl but did not contract in response to 10 mM caffeine, suggesting that the heterologous desensitization is caused by a modification of an intracellular Ca2(+)-store, which is used by both histamine and methacholine. (
  • Histamine is active biologically, but the first step for its inactivation involves the addition of a methyl group (CH 3 ) followed by a chemical oxidation. (
  • This putative second causative agent, possibly saurine (histamine hydrochloride), may enhance the activity of histamine, facilitate its absorption, or prevent its inactivation by histamine N- methyltransferase or diamine oxidase. (
  • Histamine deficiency promotes inflammation-associated carcinogenesis t" by Xiang Dong Yang, Walden Ai et al. (
  • Histamine Receptor Blockade in the Treatment of Alzheimer's Disease: " by Michelle C. Carlson, JoAnn T. Tschanz et al. (
  • Together, these data have been interpreted as indicating that this increased survival pattern is due to an off-target, non-histamine receptor-mediated property of famotidine that is not shared with cimetidine. (
  • The most likely mechanisms of actions include: via antiviral activity, via novel human targets, or via the on-target mechanism described in the current FDA market authorization - famotidine is a histamine receptor H 2 antagonist (and inverse agonist). (
  • Over the last couple of years, medication and diet have established that histamine is a major migraine trigger for me. (
  • Since its first pharmacological description as an endogenous substance in 1910 ( Barger and Dale, 1910 ), histamine has proven to exert tremendous influence over a variety of physiological processes. (
  • When this happens, the eyes produce a substance called histamine which can cause you to feel a gritty feeling in your eyes as well as burning, itching, swelling, redness, and tearing. (
  • An example of a typical histamine toxicity rash, in this case from tuna. (
  • It has been suggested that the histamine subtype 3 receptor inverse agonists such as MK-0249 might be effective in treating attention-deficit/hyperactivity disorder (ADHD). (
  • Transdermal histamine offers promise, and adenosine monophosphate may sometimes benefit. (
  • Results suggest that NO that was presumably derived from the sympathetic nervous system regulates airway responsiveness to histamine in guinea pigs. (
  • Histamine is a chemical in the body that acts as a messenger in the immune system . (
  • Body Ecology's Histamine Reducing Probiotic is a high-quantity blend of 6 highly potent probiotic strains, formulated to maximize health benefits and maintain a well-balanced immune system. (
  • It was a Trigger, my histamine levels shoot up, and although I didn't swell up, I felt vertigo, blood pressure drop, heart rate up, dizzy, a pressure in my jaw, face, my body temperature inside was changing from cold to hot. (
  • The calcium dependence of potassium chloride-, prostaglandin F2 alpha (PGF2 alpha)-, and histamine-induced contractions of human chorionic vasculature segments was investigated. (
  • Sgnificant histamine is excreted unchanged in the presence of these diseases: (a) systemic mastocytosis, (b) gastric carcinoid syndrome or (c) urticaria pigmentosa. (
  • Histamine is known as a regulator of gastrointestinal functions, such as gastric acid production, intestinal motility, and mucosal ion secretion. (
  • Asthma endophenotypes and polymorphisms in the histamine receptor HRH4 gene. (
  • Genetic Variation in the Histamine Production, Response, and Degradation Pathway Is Associated with Histamine Pharmacodynamic Response in Children with Asthma. (
  • Genetic variation within the histamine pathway among patients with asthma--a pilot study. (
  • We utilized a novel dual-sensing approach, where an iridium oxide sensor was used to monitor pH and a boron-doped diamond electrode was used for the detection of histamine from in vitro guinea pig stomach mucosal sections. (
  • 2. Histamine H1-receptor-mediated contractions appear to be rapidly reduced after application of 100 microM histamine. (
  • 3. Initial contractions to 0.3 microM histamine were reduced by 90%, recovered quickly, but did not reach control levels within 1 h. (
  • 7. The protein kinase C activator, phorbol-12,13-dibutyrate, concentration-dependently inhibited histamine- and methacholine-induced contractions. (
  • This article explains foods with high levels of histamines and how to eat a low-histamine diet. (
  • Aged cheeses have the highest levels of histamine. (
  • I just bought a supplement called UmbrellexDAO to help with my histamine levels as well as Quercetin. (
  • When histamine levels get too high or when histamine cannot break down properly, it can affect your normal bodily functions. (
  • Going on a low-histamine, low carb diet is what I am doing right now as well as taking the UmbrellexDAO and quercetin, I also watch oxalate levels and consume high oxalate foods sparingly. (
  • Recovery experiments showed that the recovery of histamine is good, between 97.7 and 102 %, for all tested sample matrixes and concentration levels (approximately 2-180 mg/kg). (
  • Histamine levels in infested homes were 20X higher than normal. (
  • The researchers found that histamine levels in infested homes were at least 20-times higher than levels in bed-bug free homes. (
  • Researchers writing in PLOS ONE also found that those histamine levels linger. (
  • In infested homes that were heat treated-which involves circulating hot air (~50 ̊C) into a home to wipe out the bugs-histamine levels remained high for months afterward. (
  • To begin to answer the question, they set out to see if histamine levels are even a measurable problem in infested houses. (
  • They also noted that heat treatments did not significantly flush histamine levels in the subsequent 12 weeks. (
  • Under stimulated conditions with ACh, the gastrin and histamine components of the total acid secretion were not altered compared with levels observed under basal conditions, suggestive that ACh had no direct effect on the enterochromaffin-like cell and G cell. (
  • Clinical evidence as far back as the early 80s supports this notion, with research showing migraineurs have increased levels of histamine in their blood and in studying the role of antihistamines in migraine prevention. (
  • If confirmation is required, histamine levels in uneaten portions of the suspect fish can be measured. (
  • In addition, elevated histamine levels can be measured in patients' urine. (
  • In healthy fish, histamine is normally present at levels less than 0.1 mg per 100 g. (