Histamine. Medical search

An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)

The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.

A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5)

Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.

Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.

A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H3 receptors were first recognized as inhibitory autoreceptors on histamine-containing nerve terminals and have since been shown to regulate the release of several neurotransmitters in the central and peripheral nervous systems. (From Biochem Soc Trans 1992 Feb;20(1):122-5)

Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.

An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to histamine, forming N-methylhistamine, the major metabolite of histamine in man. EC 2.1.1.8.

A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.

Histamine substituted in any position with one or more methyl groups. Many of these are agonists for the H1, H2, or both histamine receptors.

An enzyme that catalyzes the decarboxylation of histidine to histamine and carbon dioxide. It requires pyridoxal phosphate in animal tissues, but not in microorganisms. EC 4.1.1.22.

A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.

Drugs that selectively bind to but do not activate HISTAMINE H3 RECEPTORS. They have been used to correct SLEEP WAKE DISORDERS and MEMORY DISORDERS.

Drugs used for their actions on histaminergic systems. Included are drugs that act at histamine receptors, affect the life cycle of histamine, or affect the state of histaminergic cells.

A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.

A histamine H2 receptor antagonist that is used as an anti-ulcer agent.

A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.

Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.

A potent mast cell degranulator. It is involved in histamine release.

Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.

A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.

A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.

A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.

An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.

An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.

A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.

Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.

Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.

An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.

The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)

Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.

A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)

Hydrochloric acid present in GASTRIC JUICE.

A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.

A group of compounds that are derivatives of beta-methylacetylcholine (methacholine).

A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.

A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.

The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)

Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)

Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.

Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.

The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.

Neuroendocrine cells in the glands of the GASTRIC MUCOSA. They produce HISTAMINE and peptides such as CHROMOGRANINS. ECL cells respond to GASTRIN by releasing histamine which acts as a paracrine stimulator of the release of HYDROCHLORIC ACID from the GASTRIC PARIETAL CELLS.

Histidine substituted in any position with one or more methyl groups.

An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.

A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.

A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

A family of hexahydropyridines.

A plant genus of the family FABACEAE that is the source of mucuna gum.

An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.

A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.

The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.

Spasmodic contraction of the smooth muscle of the bronchi.

A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.

Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).

The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.

A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Abnormal passage communicating with the STOMACH.

Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.

Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.

A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.

A subtype of enteroendocrine cells found in the gastrointestinal MUCOSA, particularly in the glands of PYLORIC ANTRUM; DUODENUM; and ILEUM. These cells secrete mainly SEROTONIN and some neuropeptides. Their secretory granules stain readily with silver (argentaffin stain).

An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.

A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.

The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.

A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.

An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.

The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.

A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.

A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.

The sudden, forceful, involuntary expulsion of air from the NOSE and MOUTH caused by irritation to the MUCOUS MEMBRANES of the upper RESPIRATORY TRACT.

Major changes in the brain histamine system of the ground squirrel Citellus lateralis during hibernation. (1/3980)

Hibernation in mammals such as the rodent hibernator Citellus lateralis is a physiological state in which CNS activity is endogenously maintained at a very low, but functionally responsive, level. The neurotransmitter histamine is involved in the regulation of diurnal rhythms and body temperature in nonhibernators and, therefore, could likely play an important role in maintaining the hibernating state. In this study, we show that histamine neuronal systems undergo major changes during hibernation that are consistent with such a role. Immunohistochemical mapping of histaminergic fibers in the brains of hibernating and nonhibernating golden-mantled ground squirrels (C. lateralis) showed a clear increase in fiber density during the hibernating state. The tissue levels of histamine and its first metabolite tele-methylhistamine were also elevated throughout the brain of hibernating animals, suggesting an increase in histamine turnover during hibernation, which occurs without an increase in histidine decarboxylase mRNA expression. This hibernation-related apparent augmentation of histaminergic neurotransmission was particularly evident in the hypothalamus and hippocampus, areas of importance to the control of the hibernating state, in which tele-methylhistamine levels were increased more than threefold. These changes in the histamine neuronal system differ from those reported for the metabolic pattern in other monoaminergic systems during hibernation, which generally indicate a decrease in turnover. Our results suggest that the influence of histamine neuronal systems may be important in controlling CNS activity during hibernation. (+info)

Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea. (2/3980)

The ability of the M2 muscarinic receptor to mediate an inhibition of the relaxant effects of forskolin and isoproterenol was investigated in guinea pig ileum and trachea. In some experiments, trachea was first treated with 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) mustard to inactivate M3 receptors. The contractile response to oxotremorine-M was measured subsequently in the presence of both histamine (10 microM) and isoproterenol (10 nM). Under these conditions, [[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5, 11-dihydro-6H-pyrido[2,3b]-[1,4]benzodiazepine-6-one (AF-DX 116) antagonized the contractile response to oxotremorine-M in a manner consistent with an M3 mechanism. However, when the same experiment was repeated using forskolin (4 microM) instead of isoproterenol, the response to oxotremorine-M exhibited greater potency and was antagonized by AF-DX 116 in a manner consistent with an M2 mechanism. We also measured the effects of pertussis toxin treatment on the ability of isoproterenol to inhibit the contraction elicited by a single concentration of either histamine (0.3 microM) or oxotremorine-M (40 nM) in both the ileum and trachea. Pertussis toxin treatment had no significant effect on the potency of isoproterenol for inhibiting histamine-induced contractions in the ileum and trachea. In contrast, pertussis toxin treatment enhanced the relaxant potency of isoproterenol against oxotremorine-M-induced contractions in the ileum but not in the trachea. Also, pertussis toxin treatment enhanced the relaxant potency of forskolin against oxotremorine-M-induced contractions in the ileum and trachea. We investigated the relaxant potency of isoproterenol when very low, equi-effective (i.e., 20-34% of maximal response) concentrations of either histamine or oxotremorine-M were used to elicit contraction. Under these conditions, isoproterenol exhibited greater relaxant potency against histamine in the ileum but exhibited similar relaxant potencies against histamine and oxotremorine-M in the trachea. Following 4-DAMP mustard treatment, a low concentration of oxotremorine-M (10 nM) had no contractile effect in either the ileum or trachea. Nevertheless, in 4-DAMP mustard-treated tissue, oxotremorine-M (10 nM) reduced the relaxant potency of isoproterenol against histamine-induced contractions in the ileum, but not in the trachea. We conclude that in the trachea the M2 receptor mediates an inhibition of the relaxant effects of forskolin, but not isoproterenol, and the decreased relaxant potency of isoproterenol against contractions elicited by a muscarinic agonist relative to histamine is not due to activation of M2 receptors but rather to the greater contractile stimulus mediated by the M3 receptor compared with the H1 histamine receptor. (+info)

Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. (3/3980)

Urocortin (Ucn) is related to corticotropin-releasing hormone (CRH), and both are released in the brain under stress where they stimulate CRH 1 and 2 receptors (CRHR). Outside the brain, they may have proinflammatory actions through activation of mast cells, which are located perivascularly close to nerve endings and degranulate in response to acute psychological stress. Here, we report that a concentration of intradermal Ucn as low as 10 nM induced dose-dependent rat skin mast cell degranulation and increased vascular permeability. This effect appeared to be equipotent to that of calcitonin gene-related peptide and neurotensin. Ucn-induced skin vasodilation was inhibited by pretreatment with the mast cell stabilizer disodium cromoglycate (cromolyn) and was absent in the mast cell-deficient W/Wv mice. The selective nonpeptide CRH receptor 1 antagonist, antalarmin and the nonselective peptide antagonist astressin both reduced vascular permeability triggered by Ucn but not that by Substance P or histamine. In contrast, the peptide antagonist alpha-helical CRH-(9-41) reduced the effect of all three. The vasodilatory effect of Ucn was largely inhibited by pretreatment with H1 receptor antagonists, suggesting that histamine is the major mediator involved in vitro. Neuropeptide depletion of sensory neurons, treatment with the ganglionic blocker hexamethonium, or in situ skin infiltration with the local anesthetic lidocaine did not affect Ucn-induced vascular permeability, indicating that its in situ effect was not mediated through the peripheral nervous system. These results indicate that Ucn is one of the most potent triggers of rat mast cell degranulation and skin vascular permeability. This effect of Ucn may explain stress-induced disorders, such as atopic dermatitis or psoriasis, and may lead to new forms of treatment. (+info)

Dynamic and quantitative Ca2+ measurements using improved cameleons. (4/3980)

Cameleons are genetically-encoded fluorescent indicators for Ca2+ based on green fluorescent protein variants and calmodulin (CaM). Because cameleons can be targeted genetically and imaged by one- or two-photon excitation microscopy, they offer great promise for monitoring Ca2+ in whole organisms, tissues, organelles, and submicroscopic environments in which measurements were previously impossible. However, the original cameleons suffered from significant pH interference, and their Ca2+-buffering and cross-reactivity with endogenous CaM signaling pathways was uncharacterized. We have now greatly reduced the pH-sensitivity of the cameleons by introducing mutations V68L and Q69K into the acceptor yellow green fluorescent protein. The resulting new cameleons permit Ca2+ measurements despite significant cytosolic acidification. When Ca2+ is elevated, the CaM and CaM-binding peptide fused together in a cameleon predominantly interact with each other rather than with free CaM and CaM-dependent enzymes. Therefore, if cameleons are overexpressed, the primary effect is likely to be the unavoidable increase in Ca2+ buffering rather than specific perturbation of CaM-dependent signaling. (+info)

On the mechanism of histaminergic inhibition of glutamate release in the rat dentate gyrus. (5/3980)

1. Histaminergic depression of excitatory synaptic transmission in the rat dentate gyrus was investigated using extracellular and whole-cell patch-clamp recording techniques in vitro. 2. Application of histamine (10 microM, 5 min) depressed synaptic transmission in the dentate gyrus for 1 h. This depression was blocked by the selective antagonist of histamine H3 receptors, thioperamide (10 microM). 3. The magnitude of the depression caused by histamine was inversely related to the extracellular Ca2+ concentration. Application of the N-type calcium channel blocker omega-conotoxin (0. 5 or 1 microM) or the P/Q-type calcium channel blocker omega-agatoxin (800 nM) did not prevent depression of synaptic transmission by histamine. 4. The potassium channel blocker 4-aminopyridine (4-AP, 100 microM) enhanced synaptic transmission and reduced the depressant effect of histamine (10 microM). 4-AP reduced the effect of histamine more in 2 mM extracellular calcium than in 4 mM extracellular calcium. 5. Histamine (10 microM) did not affect the amplitude of miniature excitatory postsynaptic currents (mEPSCs) and had only a small effect on their frequency. 6. Histaminergic depression was not blocked by an inhibitor of serine/threonine protein kinases, H7 (100 microM), or by an inhibitor of tyrosine kinases, Lavendustin A (10 microM). 7. Application of adenosine (20 microM) or the adenosine A1 agonist N6-cyclopentyladenosine (CPA, 0.3 microM) completely occluded the effect of histamine (10 microM). 8. We conclude that histamine, acting on histamine H3 receptors, inhibits glutamate release by inhibiting presynaptic calcium entry, via a direct G-protein-mediated inhibition of multiple calcium channels. Histamine H3 receptors and adenosine A1 receptors act upon a common final effector to cause presynaptic inhibition. (+info)

Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. (6/3980)

Neutrophilic inflammation in small airways (SA) and bronchospasm mediated via muscarinic receptors are features of chronic obstructive pulmonary disease in horses (COPD). Histamine, serotonin, and leukotrienes (LTs) are reported to be involved in the exacerbation of COPD, and currently, histamine has been shown to increase tension response to electrical field simulation (EFS) in equine SA. We tested the effects of these mediators and the effects of activated neutrophils on the cholinergic responses in SA. Histamine, serotonin, and LTD4 had a synergistic effect on EFS responses and only an additive effect on the tension response to exogenous ACh or methacholine. Atropine and TTX entirely eliminated the EFS-induced tension response in the presence of all three inflammatory mediators, indicating that augmentation of the EFS response applies only to the endogenous cholinergic response. Neutrophils isolated from control and COPD-affected horses were activated by zymosan, producing 18.1 +/- 2.3 and 25.0 +/- 2.3 nmol superoxide. 10(6) cells-1. 30 min-1, respectively. However, in contrast to the profound effect of mediators, incubation of SA for over 1 h in a suspension of up to 30 x 10(6) zymosan-treated neutrophils/ml did not significantly affect EFS responses of SA isolated from either control or COPD-affected horses. We conclude that in equine SA 1) the endogenous cholinergic responses are subject to strong facilitation by inflammatory mediators; 2) activated neutrophils do not affect cholinergic responses in SA; and 3) in acute bouts of equine COPD, histamine, LTD4, and serotonin (mediators primarily associated with type I allergic reaction) rather than mediators derived from neutrophils most likely contribute to increased cholinergic airway tone. (+info)

Exhaled nitric oxide; relationship to clinicophysiological markers of asthma severity. (7/3980)

Bronchial asthma is an airway disorder associated with bronchial hyperresponsiveness, variable airflow obstruction and elevated levels of nitric oxide (NO) in exhaled air. The variables all reflect, in part, the underlying airway inflammation in this disease. To understand their interrelationships we have investigated the relationship between exhaled NO levels and clinicophysiological markers of asthma severity. Twenty-six steroid naive atopic asthmatics participated in the analysis. All were given diary cards and were asked to record their peak expiratory flow (PEF) rates twice daily together with their asthma symptom scores and beta-agonist use. Diary cards were collected 2 weeks later and measurements of exhaled NO levels, FEV1 and histamine bronchial hyperreactivity (PC20 histamine) were undertaken. Exhaled NO levels were significantly higher in our study population than in normal control subjects and correlated negatively with PC20 histamine (r = -0.51; P = 0.008) and positively with PEF diurnal variability (r = 0.58; P = 0.002), but not with symptom scores, beta-agonist use of FEV1 (%). We conclude that a significant relationship exists between exhaled NO levels and the two characteristic features and markers of asthma severity, namely bronchial hyperreactivity and PEF diurnal variability. The lack of correlation between symptom score and beta-agonist use, of FEV1 (%) predicted and exhaled NO suggests that these measures are reflective of differing aspects of asthma. (+info)

Strain-dependent induction of allergic sensitization caused by peanut allergen DNA immunization in mice. (8/3980)

To investigate the potential application of allergen gene immunization in the modulation of food allergy, C3H/HeSn (C3H) mice received i.m. injections of pAra h2 plasmid DNA encoding one of the major peanut allergens, Ara h2. Three weeks following pDNA immunization, serum Ara h2-specific IgG2a, IgG1, but not IgE, were increased significantly in a dose-dependent manner. IgG1 was 30-fold higher in multiply compared with singly immunized mice. Ara h2 or peanut protein injection of immunized mice induced anaphylactic reactions, which were more severe in multiply immunized mice. Heat-inactivated immune serum induced passive cutaneous anaphylaxis, suggesting that anaphylaxis in C3H mice was mediated by IgG1. IgG1 responses were also induced by intradermal injection of pAra h2, and by i.m. injection of pOMC, the plasmid DNA encoding the major egg allergen protein, ovomucoid. To elucidate whether the pDNA immunization-induced anaphylaxis was a strain-dependent phenomenon, AKR/J and BALB/c mice also received multiple i.m. pAra h2 immunizations. Injection of peanut protein into these strains at weeks 3 or 5 following immunization did not induce reactions. Although IgG2a was increased significantly from week 2 in AKR/J mice and from week 4 in BALB/c mice and remained elevated for at least 6 wk, no IgG1 or IgE was detected. These results indicate that the type of immune responses to pDNA immunization in mice is strain dependent. Consequently, models for studying human allergen gene immunization require careful selection of suitable strains. In addition, this suggests that similar interindividual variation is likely in humans. (+info)

The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine. Histamine has two ... Histamine intolerance Histamine receptor antagonist Scombroid food poisoning Photic sneeze reflex Histamine Material Safety ... Sake contains histamine in the 20-40 mg/L range; wines contain it in the 2-10 mg/L range. Most histamine in the body is ... In humans, histamine exerts its effects primarily by binding to G protein-coupled histamine receptors, designated H1 through H4 ...

https://en.wikipedia.org/wiki/Histamine

Holger Stark: Histamine Receptors, BIOTREND Reviews No. 01, November 2007 The Histamine Receptor Histamine+Receptor at the US ... The histamine receptors are a class of G protein-coupled receptors which bind histamine as their primary endogenous ligand. ... "Histamine Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ... There are four known histamine receptors: H1 receptor H2 receptor H3 receptor H4 receptor There are several splice variants of ...

https://en.wikipedia.org/wiki/Histamine_receptor

... are substances that contain low amounts of histamine themselves but are capable of releasing histamine ... Some histamine liberators were thought to be organic bases as they are synonymous with histamine since it is a base as well, ... However, other histamine-liberating substances, such as decylamine, manifested a steady increase in histamine activity with ... The crux of this theory lies in the assumption that histamine liberators release histamine by displacing it from cells. The ...

https://en.wikipedia.org/wiki/Histamine_liberators

... , sometimes called histaminosis, is an over-accumulation of dietary histamine in the human body. Histamine ... because they are known to release histamine stored in the body (histamine liberation). If eating histamine-containing foods is ... The imbalance in histamine intolerance is between the synthesis and selective release of histamine from certain granulocytes (i ... At the same time, the histamine blood level halves and the DAO increases significantly. If there is no histamine intolerance, ...

https://en.wikipedia.org/wiki/Histamine_intolerance

... (INN, trade name Ceplene) is a salt of histamine that is used as a drug for the prevention of relapse ... The combination of histamine dihydrochloride and interleukin-2 was approved for use in AML patients within the European Union ... Histamine dihydrochloride is administered in conjunction with low doses of the immune-activating cytokine interleukin-2 (IL-2) ... Histamine dihydrochloride has been developed by researchers at the University of Gothenburg, Sweden. Federal Register, volume ...

https://en.wikipedia.org/wiki/Histamine_dihydrochloride

A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes. H2: ... Histamine antagonist Histamine+agonist at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of ... H3: Betahistine is a weak Histamine1 agonist and a very strong Histamine3 antagonist (paradoxically histamine increasing). ... Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine. ...

https://en.wikipedia.org/wiki/Histamine_agonist

Histamine receptor antagonists H1-receptor antagonist Histamine H2-receptor Histamine H3-receptor Histamine H4-receptor GRCh38 ... Histamine H1 receptors are activated by endogenous histamine, which is released by neurons that have their cell bodies in the ... While the best characterized function of the histamine system in the brain is regulation of sleep and arousal, histamine is ... Horváth BV, Szalai C, Mándi Y, László V, Radvány Z, Darvas Z, Falus A (Nov 1999). "Histamine and histamine-receptor antagonists ...

https://en.wikipedia.org/wiki/Histamine_H1_receptor

... histamine receptor antagonists H3-receptor antagonist Histamine H1-receptor Histamine H2-receptor Histamine H4-receptor GRCh38 ... "Histamine and Histamine Receptors in Tourette Syndrome and Other Neuropsychiatric Conditions." Neuropharmacology 106 (July 2016 ... Mouse-models and other research demonstrated that reducing histamine concentration in the H3R causes tics, but adding histamine ... Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where ...

https://en.wikipedia.org/wiki/Histamine_H3_receptor

Inhibition of neutrophil activation and chemotaxis H2-receptor antagonist Histamine H1-receptor Histamine H3-receptor Histamine ... Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The histamine receptor H2 belongs to the rhodopsin- ... The drug betazole is an example of a histamine H2 receptor agonist. Histamine is a ubiquitous messenger molecule released from ... Classification of histamine receptors". Pharmacological Reviews. 49 (3): 253-78. PMID 9311023. "Entrez Gene: HRH2 histamine ...

https://en.wikipedia.org/wiki/Histamine_H2_receptor

... (HNMT, HMT) is an enzyme involved in the metabolism of histamine. It is one of two enzymes ... In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative ... Methylated histamine metabolites are excreted with urine. In mammals, histamine is metabolized by two major pathways: oxidative ... Although the relationship between histamine and IL-8 has not been fully studied as of 2020[update], it is known that histamine ...

https://en.wikipedia.org/wiki/Histamine_N-methyltransferase

Histamine H1-receptor Histamine H2-receptor Histamine H3-receptor GRCh38: Ensembl release 89: ENSG00000134489 - Ensembl, May ... The histamine H4 receptor, like the other three histamine receptors, is a member of the G protein-coupled receptor superfamily ... "Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor". Mol. Pharmacol. ... Unlike the histamine receptors discovered earlier, H4 was found in 2000 through a search of the human genomic DNA data base. H4 ...

https://en.wikipedia.org/wiki/Histamine_H4_receptor

... (HTFMT) is a mixed H1/H2 histamine agonist which is significantly more potent than ... Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. Journal of ... It also produces additional actions which appear to be independent of histamine receptors. Whyment AD, Blanks AM, Lee K, Renaud ... Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of ...

https://en.wikipedia.org/wiki/Histamine_trifluoromethyl_toluidide

Histamines are proteins associated with many allergic reactions. When the UV radiation or light comes in contact with a person ... "Histamine". Davidson College. 2000. Retrieved 2008-11-01. Taranova, NP (1975). "[Effect of whole-body x-irradiation on the ... When this occurs, the permeability of vessels near the area of histamine release is increased. This allows blood fluid to enter ... Antihistamines suppress the activity of the histamine. Diphenhydramine, a first-generation H1 receptor antagonist or medicine ...

https://en.wikipedia.org/wiki/Solar_urticaria

Hamlin, K. E.; Weston, Arthur W.; Fischer, Francis E.; Michaels, R. J. (1949). "Histamine Antagonists. II.1Unsymmetrical 1,4- ... N-METHYL-N'-BENZHYDRYLPIPERAZINES AS HISTAMINE ANTAGONISTS1". The Journal of Organic Chemistry. 14 (5): 775-782. doi:10.1021/ ...

https://en.wikipedia.org/wiki/Chlorcyclizine

Histamine alkaloids. Acacia sophorae, Tryptamine in leaves, bark Acacia macradenia, Tryptamine Acacia maidenii, 0.6% NMT and ...

https://en.wikipedia.org/wiki/List_of_psychoactive_plants

... are a class of medications that block the action of histamine at the histamine H2 receptors of the parietal cells in the ... Ranitidine was also the result of a rational drug design process utilising the by-then-fairly-refined model of the histamine H2 ... They designated the one acted upon by the traditional antihistamines as H1, and the one acted upon by histamine to stimulate ... The SK&F team used a classical design process starting from the structure of histamine. Hundreds of modified compounds were ...

https://en.wikipedia.org/wiki/H2_receptor_antagonist

Histamine also promotes angiogenesis. Antihistamines suppress the histamine-induced wheal response (swelling) and flare ... by blocking the binding of histamine to its receptors or reducing histamine receptor activity on nerves, vascular smooth muscle ... which modulate the release of histamine. Histamine release in the brain triggers secondary release of excitatory ... Normally, histamine acts on H2 to stimulate acid secretion; drugs that inhibit H2 signaling thus reduce the secretion of ...

https://en.wikipedia.org/wiki/Antihistamine

Maintz L, Novak N (2007). "Histamine and histamine intolerance". Am J Clin Nutr. 85 (5): 1185-96. doi:10.1093/ajcn/85.5.1185. ... Food allergies are immune reactions, typically an IgE reaction caused by the release of histamine but also encompassing non-IgE ... Maintz L, Benfadal S, Allam JP, Hagemann T, Fimmers R, Novak N (May 2006). "Evidence for a reduced histamine degradation ... Götz M (1996). "[Pseudo-allergies are due to histamine intolerance]". Wien Med Wochenschr (in German). 146 (15): 426-30. PMID ...

https://en.wikipedia.org/wiki/Food_intolerance

By reversing the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms. It also crosses the ... Histamine, Bradykinin, and Their Antagonists". In Brunton L (ed.). Goodman & Gilman's The Pharmacological Basis of Therapeutics ... Krystal AD, Richelson E, Roth T (August 2013). "Review of the histamine system and the clinical effects of H1 antagonists: ... Ghoneim OM, Legere JA, Golbraikh A, Tropsha A, Booth RG (October 2006). "Novel ligands for the human histamine H1 receptor: ...

https://en.wikipedia.org/wiki/Diphenhydramine

... anti-histamine); Atovaquone (PCP/Malaria); Exosurf (infant respiratory distress); Mivacron and Nuromax (neuromuscular blockade ...

https://en.wikipedia.org/wiki/Trevor_M._Jones

Histaminergic neurons-histamine. Histamine is a monoamine neurotransmitter and neuromodulator. Histamine-producing neurons are ... Histamine is involved in arousal and regulating sleep/wake behaviors. Since 2012 there has been a push from the cellular and ... Scammell TE, Jackson AC, Franks NP, Wisden W, Dauvilliers Y (January 2019). "Histamine: neural circuits and new medications". ...

https://en.wikipedia.org/wiki/Neuron

Before the test each subject was given an antihistamine which blocked all of the effects of histamine apart from its effect on ... His paper describing this test, Effect of Large Doses of Histamine on Gastric Secretion of HCl, became the single most cited ... He developed the augmented histamine test, which bore his name, and was widely used in the investigation and treatment of ... Kay used increasing doses of histamine to stimulate acid production and found that acid production was higher in patients with ...

https://en.wikipedia.org/wiki/Andrew_Watt_Kay

... and histamine N-methyltransferase (HNMT), which methylates histamine in the process of histamine metabolism. Catechol-O- ... "HNMT histamine N-methyltransferase". NCBI Genetic Testing Registry. Retrieved 18 February 2014. "COMT catechol-O- ...

https://en.wikipedia.org/wiki/Methyltransferase

Rapanelli M, Pittenger C (July 2016). "Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric ... Histamine and the H3 receptor may play a role in the alterations of neural circuitry. A reduced level of histamine in the H3 ... Sadek B, Saad A, Sadeq A, Jalal F, Stark H (October 2016). "Histamine H3 receptor as a potential target for cognitive symptoms ... Rapanelli M (February 2017). "The magnificent two: histamine and the H3 receptor as key modulators of striatal circuitry". Prog ...

https://en.wikipedia.org/wiki/Tourette_syndrome

Maintz, Laura; Novak, N (May 2007). "Histamine and histamine intolerance". The American Journal of Clinical Nutrition. 85 (5): ... alcohol consumption may lead to elevated plasma histamine levels even in the absence of histamines in the beverage consumed. A ... Histamine is present in a variety of fermented products such as wine, aged cheeses, and sauerkraut. Red wine has 20-200% more ... Alcohol flush reaction Browning in red wine Food intolerance Headache Histamine intolerance Wine and health Wine fault K. ...

https://en.wikipedia.org/wiki/Red_wine_headache

For example, histamine is biosynthesised strictly via the enzyme histidine decarboxylase in humans and other organisms. In ... Huang H, Li Y, Liang J, Finkelman FD (2018). "Molecular Regulation of Histamine Synthesis". Frontiers in Immunology. 9: 1392. ... chikawa A, Tanaka S (2012). "Histamine Biosynthesis and Function". eLS. American Cancer Society. doi:10.1002/9780470015902. ... a trace amine neuromodulator L-Histidine to histamine - a neurotransmitter L-Tryptophan to tryptamine - a trace amine ...

https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase

R. Bowen (2008). "Histamine and Histamine Receptors". "Excitotoxicity and Cell Damage". 2010. M. Aarts; M. Tymianski (2003-09- ... Histamine acts as an excitatory neurotransmitter by binding G-protein coupled receptors in neurons of the hypothalamus. These ... Of the four types of histamine receptors (H1 - H4), H3 is found in the central nervous system and is responsible for regulating ... histamine effects on neurotransmission. Excitatory synapses have a fundamental role in information processing within the brain ...

https://en.wikipedia.org/wiki/Excitatory_synapse

"Histamine: Friend or Foe? , House Online Neurotology Education Program." YouTube, YouTube, 19 May 2021, www.youtube.com/watch?v ...

https://en.wikipedia.org/wiki/Cochlear_hydrops

Ganellin, C. R.; Parsons, M. E. (1982). Pharmacology of Histamine Receptors. Butterworth-Heinemann. ISBN 978-0-7236-0589-8. " ...

https://en.wikipedia.org/wiki/The_Frythe

Patients were given injections of histamine of increasing strength for up to 24 days. The treatment caused their blood pressure ... Some patients received combination treatments of histamine coupled with insulin or ECT. Sackler and his wife Else began ... S2CID 35613071.{{cite journal}}: CS1 maint: multiple names: authors list (link) Lucy, John D. (1954). "Histamine Tolerance in ... "The Technique of Histamine Biochemo-therapy and Suggestions for its Use in Psychiatry". The Journal of Nervous and Mental ...

https://en.wikipedia.org/wiki/Arthur_M._Sackler

The histamine response can produce sneezing, itching, hives and watery eyes. ... Mast cells release histamine when an allergen is encountered. ... Mast cells release histamine when an allergen is encountered. ...

https://medlineplus.gov/ency/imagepages/19333.htm

Histamine H2-Receptor Antagonists. Class Summary. These agents are usually given in addition to H1 blockers. ... This agent inhibits histamine at H2 receptors of gastric parietal cells, which results in reduced gastric acid secretion, ... Fexofenadine competes with histamine for H1 receptors in the GI tract, blood vessels, and respiratory tract, reducing ... Famotidine competitively inhibits histamine at the H2 receptors in gastric parietal cells, reducing gastric acid secretion, ...

https://emedicine.medscape.com/article/1050485-medication

Histamine in Salmonids: joint FAO/WHO literature review World Health Organization; Food and Agriculture Organization of the ... Joint FAO/WHO expert meeting on the public health risks of histamine and other biogenic amines from fish and fishery products: ... Histamine poisoning associated with fish, cheese, and other foods / by Steve L. Taylor ...

https://extranet.who.int/iris/restricted/browse?authority=Histamine&type=mesh

In this podcast DrA will answer questions around histamine pathology and management and those questions that followed the ... https://www.consultdranderson.com/product/histamine-role-brain-body/ https://www.consultdranderson.com/product/ ...

https://www.podbean.com/site/EpisodeDownload/PBB1236078EBH

... - The Environmental Illness Resource , Information & Community ... Biogenic Amines and Histamine Intolerance Featured When thinking about how food sensitivities and/or intolerances may be ... The most well known biogenic amines are the neurotransmitters serotonin, dopamine, and noradrenaline, and histamine, best known ... such as the inflammation produced by histamine release), or regulate functions of the gut. The classic neurotransmitters ...

https://www.ei-resource.org/easyblog/tags/tag/histamine/

Histamine H2 antagonists. Class Summary. This class is for the symptomatic relief of reflux resulting from esophageal ... Ranitidine inhibits histamine stimulation of the H2 receptor in gastric parietal cells, which, in turn, reduces gastric acid ... Nizatidine competitively inhibits histamine at the H2 receptor of the gastric parietal cells, resulting in reduced gastric acid ... Famotidine competitively inhibits histamine at the H2 receptor of gastric parietal cells, resulting in reduced gastric acid ...

https://www.medscape.com/answers/1064663-80875/which-medications-in-the-drug-class-calcium-channel-blockers-are-used-in-the-treatment-of-crest-syndrome

Histamine dihydrochloride , C5H11Cl2N3 , CID 5818 - structure, chemical names, physical and chemical properties, classification ...

https://pubchem.ncbi.nlm.nih.gov/compound/5818

The full functional implications of pharmacogenetic variation in the activities of catechol O-methyltransferase and histamine N ... Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase ... and histamine N-methyltransferase. In recent years, characterization of these genetic polymorphisms has been extended to ...

https://pubmed.ncbi.nlm.nih.gov/10331075/?dopt=Abstract

Although interest in histamine intolerance has considerably grown in recent years, more scientific evidence is still required ... In this work, a glance on histamine intoxication will also be provided, as well as the analysis of some uncertainties ... This article will provide an updated review on histamine intolerance, mainly focusing on its etiology and the existing ... is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning of the ...

https://www.mdpi.com/2218-273X/10/8/1181

Histamine H2 Antagonists. Class Summary. Cytochrome P-450 inhibitors are recommended only for patients with methemoglobinemia ...

https://emedicine.medscape.com/article/204178-medication

Learn more about high histamine foods that some people choose to avoid. ... Histamine produced in the body is a key mediator in allergic reactions. ... Low-Histamine Diet Some people choose a low-histamine diet. This diet reduces the amount of high-histamine foods and those ... Histamine Intolerance Histamine intolerance is also called food histaminosis and hypersensitivity to food histamine, but it has ...

https://www.verywellhealth.com/high-histamine-foods-5223261

J:4933 Sudweeks JD, et al., Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune ...

http://www.informatics.jax.org/marker/MGI:107619

Diagnostic value of the insulin-histamine test in stomach diseases]. Download Prime PubMed App to iPhone, iPad, or Android ... AdultDuodenal UlcerGastric JuiceGastric MucosaGastritisHistamineHumansInsulinMiddle AgedStomach Neoplasms ... Kravets, M G.. "[Diagnostic Value of the Insulin-histamine Test in Stomach Diseases]." Vrachebnoe Delo, vol. 2, 1972, pp. 21-4. ... Kravets, M. G. (1972). [Diagnostic value of the insulin-histamine test in stomach diseases]. Vrachebnoe Delo, 2, 21-4. ...

https://www.unboundmedicine.com/medline/citation/5084736/%5BDiagnostic_value_of_the_insulin_histamine_test_in_stomach_diseases%5D_

Low histamine, corn, egg, nightshade, nut, peanut, sesame, soya free; can be gluten, lactose, milk & wheat free ... Low histamine, corn, egg, nightshade, nut, peanut, sesame, soya free; can be gluten, lactose, milk & wheat free ...

https://foodsmatter.com/freefrom_recipes/recipes/histamine/mbj-apricot-brown-betty-08-17.html

... experts discuss the uniqueness of pitolisant as a treatment option within the setting of narcolepsy and the role histamine ... If you cut the brake cable, guess what? Histamine comes out, and the histamine comes out and wakes you up. ... It is pro histamine. Usually I say its histaminergic, but every audience Ive had since I started talking about this hears ... You want to boost histamine in your brain, and you can do that by a couple of different mechanisms. Did you know that the ...

https://www.psychiatrictimes.com/view/pitolisant-and-the-role-of-histamine-in-narcolepsy

I posted previously about how I think the methylated supplements contributed to my food/med/supp sensitivites. However, I ve recently remembered that just before I expereinced these symptoms I got 3 vaccinations before taking a trip to Brazil earlier this year. It was within just days of getting these vacinnes that my symptoms began, head pressure, food reactions and difficulty breathing. I thought the breathing issue was due to the higher humidity in Brazil. I never suspected the vaccines until recently and instead thought it was the supps b/c I d read they can cause sulfur issues. ...

https://www.curezone.com/forums/fmi.asp?i=2124749

About Us , Contact Us , Advertise With Us WholeFoods Magazine is the industrys leading resource for health and nutrition articles. We provide important information regarding industry news, research, and trends.. NOTE: WholeFoods Magazine is a business-to-business publication. Information on this site should not be considered medical advice or a way to diagnose or treat any disease or illness. Always seek the advice of a medical professional before making lifestyle changes, including taking a dietary supplement. The opinions expressed by contributors and experts quoted in articles are not necessarily those of the publisher or editors of WholeFoods. ...

https://wholefoodsmagazine.com/tag/histamine-intolerance/

Ezeamuzie, C.I. & Philips, E. Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil ... and can be used to inhibit the release of histamine from human basophils and mast cells 60. Histamine may act as an autocrine ... these and other associated lung cells that are positive for histamine receptors H1 and H2 could respond to local histamine ... off-target binding of a non-histamine H2 G-coupled protein receptor 4) histamine H2 receptor inhibition. ...

https://www.researchsquare.com/article/rs-30934/v1

An introduction to the pharmacology of histamine and its antagonists is presented. ... Clinical Uses: H1 Histamine Receptor Blockers * Allergic Reactions * H1 histamine receptor blockers ... Histamine: Storage and Release * Immunologic Release: The most important mechanism for histamine release is in response to an ... Histamine: Clinical Pharmacology-- Uses * Pulmonary Function: histamine aerosol may be used to test for bronchial ...

https://pharmacology2000.com/Histamine/histamine1.htm

The DAO enzyme in our Histamine Reducing Probiotic Powder is responsible for breaking down histamine in the intestines. Our ... Body Ecology Histamine Reducing Probiotic Powder is a blend of beneficial bacteria that support the DAO enzyme and helps to ... Our Histamine Reducing Probiotic Powder breaks down excessive histamine and assists with histamine intolerance and low ... Home / Energy Boosters / Histamine Reducing Probiotic (powder probiotic) Histamine Reducing Probiotic (powder probiotic). ...

https://shop.bodyecology.com/collections/products-to-boost-energy-and-support-immunity/products/histamine-reducing-probiotic

Histamine (100 microM) induced a rapid increase in vascular tension in physiologic buffer which rapidly faded or desensitized ... The differences in responsiveness of potassium chloride, histamine, and PGF2 alpha under the various conditions used suggest ... The potential roles of PGF2 alpha, histamine, and calcium channel blockers in modulating the fetoplacental circulation is ... The calcium dependence of potassium chloride-, prostaglandin F2 alpha (PGF2 alpha)-, and histamine-induced contractions of ...

https://www.semanticscholar.org/paper/Regulation-of-the-tension-of-human-chorionic-by-and-Quist-Adams/e452537948a296fc8599946471b08c0f78faf329

Histamine intolerance is not a sensitivity to histamine, but an indication that youve developed too much of it. Histamine is a ... When histamine levels get too high or when histamine cannot break down properly, it can affect your normal bodily functions.. ... As a neurotransmitter, histamine communicates messages to your brain.. *Histamine is a component of stomach acid that helps to ... Home - Skincare Routine - Self Care - High histamines - do I have a histamine intolerance? ...

https://www.hellodollface.com/skincare-routine/self-care/high-histamines-do-i-have-a-histamine-intolerance/

Histamine is formed by microbial decarboxylation of histidine. Histidine is an essential amino acid which is present in all ... Histamine may lead to Scombroid food poisoning, which resembles allergic reactions. This method is intended for quantification ... Histamine in fish: Liquid chromatographic determination with post-column derivatization and fluorescence detection. ... Histamine in fish: Liquid chromatographic determination with post-column derivatization and fluorescence detection. ...

https://nofima.no/publikasjon/1236177/

GPCR97-Expressing Cells Bind the High-Affinity Histamine H3 LigandR-α-Methyl[3H]histamine.. To confirm the H3 pharmacology, we ... 1983) Autoinhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature (London) 302:832- ... a third subtype of histamine receptor, H3, was identified as a presynaptic autoreceptor on histamine neurons in the brain ... Cloning and Functional Expression of the Human Histamine H3 Receptor. Timothy W. Lovenberg, Barbara L. Roland, Sandy J. Wilson ...

https://molpharm.aspetjournals.org/content/55/6/1101?ijkey=5c83dab749cecebed0ed48d06e1bf033e8a6e6d8&keytype2=tf_ipsecsha

HISTAMINE DIHYDROCHLORIDE (UNII: 3POA0Q644U) (HISTAMINE - UNII:820484N8I3) HISTAMINE DIHYDROCHLORIDE. 8 [hp_X]. ... Label: BHI ALLERGY- antimony trisulfide, arnica montana root, formic acid, graphite, histamine dihydrochloride,strychnos ... BHI ALLERGY- antimony trisulfide, arnica montana root, formic acid, graphite, histamine dihydrochloride,strychnos ignatii seed ... BHI ALLERGY- antimony trisulfide, arnica montana root, formic acid, graphite, histamine dihydrochloride,strychnos ignatii seed ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e985b147-fec1-42c2-819a-67796cc2ced1

Randomized Controlled Study of the Histamine H3 Inverse Agonist MK-0249 in Adult Attention-Deficit/Hyperactivity Disorder. W. ... Background: It has been suggested that the histamine subtype 3 receptor inverse agonists such as MK-0249 might be effective in ...

https://www.psychiatrist.com/jcp/neurodevelopmental/adhd/randomized-controlled-study-histamine-h-inverse-agonist/

Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines.. G W Read and E ... Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines.. G W Read and E ... Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines.. G W Read and E ... BAC caused histamine release by itself at concentrations over 5 microgram/ml. Heat inactivation (50 degrees C for 15 min) of ...

https://jpet.aspetjournals.org/content/211/3/711

Here are tips on how to follow a low histamine diet. ... Histamine intolerance is difficult to diagnose and is often ... Im a little confused, Ive been led to believe broccoli is a low histamine food, although its on the high histamine list on ... If you are experiencing a histamine intolerance, its important to follow a LOW histamine diet for quite awhile until your body ... The tricky thing about histamines is that the reaction to foods is not immediate. Histamine intolerance is also closely linked ...

https://thehealthyapple.com/low-histamine-foods/

Histamine and Sir Henry Dale. Br Med J 1965; 1488-90.. 16 Riley JF, West GB. The presence of histamine in tissue mast cells. J ... both the general release of histamine into the blood stream of the dog and the local release of histamine into the skin of the ... You imply that histamine may be carried in the acid granules of the mast cell. This is very curious. You must do some more work ... As for histamine itself, no one yet knew where it was made, how it was stored or by what mechanism it was released. Valuable ...

https://www.rcpe.ac.uk/college/journal/dr-james-riley-pioneer-histamine-and-mast-cell-studies

... a histamine H2-blocking drug, in delaying the progression of cognitive impairment in older adults with Alzheimer disease (AD). ... H2 Histamine Receptor Blockade in the Treatment of Alzheimers Disease: A Randomized, Double-Blind Placebo-Controlled Trial of ... Histamine Receptor Blockade in the Treatment of Alzheimers Disease: A Randomized, Double-Blind Placebo-Controlled Trial of ... Objectives: To evaluate the efficacy of nizatidine, a histamine H2-blocking drug, in delaying the progression of cognitive ...

https://digitalcommons.usu.edu/psych_facpub/211/

Histamine intolerance, also referred to as enteral histaminosis or sensitivity to dietary histamine, is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning of the 21st century. (mdpi.com)
Histamine intolerance has never been proven to be a true medical disorder, but some people think that they feel better when they avoid some of these foods. (verywellhealth.com)
Vacinations contributed to my histamine intolerance/MCS. (curezone.com)
Our Histamine Reducing Probiotic Powder breaks down excessive histamine and assists with histamine intolerance and low histamine. (bodyecology.com)
do I have a histamine intolerance? (hellodollface.com)
Home - Skincare Routine - Self Care - High histamines - do I have a histamine intolerance? (hellodollface.com)
Histamine intolerance is not a sensitivity to histamine, but an indication that you've developed too much of it. (hellodollface.com)
Many Western medicine doctors do not understand the connection between high histamine foods and these symptoms, however if you are experiencing symptoms like the ones listed above, you may be suffering from a common cause of food intolerance and disease, called Histamine Intolerance. (thehealthyapple.com)
Many people haven't heard of histamine intolerance but it is a food intolerance that's difficult to diagnose and is often confused with many other conditions. (thehealthyapple.com)
Histamine intolerance is also closely linked to dysbiosis and SIBO (Small Intestinal Bacteria Overgrowth) . (thehealthyapple.com)
My Integrative doctors believe that the main cause of histamine intolerance is from an overgrowth of bad bacteria int he gut that makes histamine from foods that are not digested. (thehealthyapple.com)
If you are experiencing a histamine intolerance, it's important to follow a LOW histamine diet for quite awhile until your body is able to tolerate eating histamines again. (thehealthyapple.com)
A Cup of Coffee - Do You Have A Histamine Intolerance? (nwosteo.org)
This week we are going to talk about Histamine Intolerance. (nwosteo.org)
To date there is no clear cause of histamine intolerance, and the diagnosis is therefore difficult. (frusano.com)
Diagnosing histamine intolerance requires a comprehensive physician's review of the patient's lifestyle, nutritional habits, and symptoms. (frusano.com)
Since the symptoms are unspecific, other diagnoses should be considered along with histamine intolerance. (frusano.com)
If, after other causes have been ruled out, the suspicion of a histamine intolerance still exists, the next step is an elimination diet followed by a provocation test (also known as a histamine challenge). (frusano.com)
If the symptoms improve during this time, this provides evidence of histamine intolerance. (frusano.com)
If they detect the known symptoms from a certain histamine load, this is considered to be evidence of the histamine intolerance. (frusano.com)
Almost a month ago I blogged about Histamine Intolerance, a widespread and under diagnosed condition. (judytsafrirmd.com)
Histamine Intolerance can be used as a frame work to understand the connection between many different symptoms, and to provide an understanding of the way that they are linked by a common underlying pathophysiology. (judytsafrirmd.com)
Histamine intolerance flies beneath the radar of most doctors, and can easily result in a misguided treatment approach. (judytsafrirmd.com)
Histamine Intolerance is a modern day Great Pretender. (judytsafrirmd.com)
I continued to research on the internet, and came upon a site called The Reluctant Raw Foodist , which was written by a woman with severe Histamine Intolerance who had similar symptoms to Sandra. (judytsafrirmd.com)
Prominent psychiatric symptoms can be the presenting complaint of a patient suffering from Histamine Intolerance, with anxiety, panic and insomnia. (judytsafrirmd.com)
When a patient tries to discontinue the drug, symptoms of histamine intolerance can manifest, such as profound insomnia and anxiety, and it can be difficult to come off the medications. (judytsafrirmd.com)
Causes include the possibility of a genetic component, histamine intolerance, and possible food allergies. (cdc.gov)
Learn the root causes behind this as well as treatment solutions for this and histamine intolerance. (mindbodyfunctionalmedicine.com)

Fexofenadine competes with histamine for H1 receptors in the GI tract, blood vessels, and respiratory tract, reducing hypersensitivity reactions. (medscape.com)
Desloratadine is a long-acting tricyclic histamine antagonist selective for H1 receptors. (medscape.com)
Famotidine competitively inhibits histamine at the H2 receptors in gastric parietal cells, reducing gastric acid secretion, gastric volume, and hydrogen concentrations. (medscape.com)
It's going to be dancing on those postsynaptic H1 receptors-histamine itself, but the drug releases histamine. (psychiatrictimes.com)
Histamine mediates its effects by interacting with receptors. (pharmacology2000.com)
Histamine regulates neurotransmitter release in the central and peripheral nervous systems through H 3 presynaptic receptors. (aspetjournals.org)
In contrast, in humans, expression and distribution of histamine receptors (HR) within the human gastrointestinal tract are unclear. (bmj.com)
Drugs that selectively bind to but do not activate HISTAMINE H3 RECEPTORS. (uams.edu)
In an attempt to extend recent studies showing that some clinically evaluated histamine H3 receptor (H3R) antagonists possess nanomolar affinity at sigma-1 receptors (σ1R), we selected 20 representative structures among our previously reported H3R ligands to investigate their affinity at σRs. (ugr.es)

The so-called antihistamines are H1 postsynaptic antagonists, and you must know that histamine is a neurotransmitter in the brain. (psychiatrictimes.com)
Histamine H3 Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
This graph shows the total number of publications written about "Histamine H3 Antagonists" by people in UAMS Profiles by year, and whether "Histamine H3 Antagonists" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Histamine H3 Antagonists" by people in Profiles over the past ten years. (uams.edu)
Interestingly, both ligands turned out to be high-affinity histamine H3 and σ1 receptor antagonists with negligible affinity at the other histamine receptor subtypes and promising antinociceptive activity in vivo. (ugr.es)
Examples include proton pump inhibitors (PPIs) and histamine H2-receptor antagonists (H2 blockers), which are used to reduce acid reflux symptoms and may be available without a prescription. (cyberincomesolutions.com)
15. Anti-histamines (H1-receptor antagonists) (M. Andersen). (who.int)

As a neurotransmitter, histamine communicates messages to your brain. (hellodollface.com)
Its widespread and abundant neuronal expression in the brain highlights the significance of histamine as a general neurotransmitter modulator. (aspetjournals.org)

This undigested food builds up in your body and overwhelms your body- therefore you're left with excess histamine. (thehealthyapple.com)
Answer: They could all be manifestations of excess histamine in the body. (judytsafrirmd.com)

Transfection of GPCR97 into a variety of cell lines conferred an ability to inhibit forskolin-stimulated cAMP formation in response to histamine, but not to acetylcholine or any other biogenic amine. (aspetjournals.org)
Gastric acid secretion is regulated by three primary components that activate the parietal cell: histamine, gastrin, and acetylcholine (ACh). (warwick.ac.uk)
We investigated how NO derived from the airway nervous system would affect the airway responsiveness to histamine and acetylcholine in mechanically ventilated guinea pigs. (elsevier.com)
An NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L- NAME) (1 mmol/kg ip) significantly enhanced airway responsiveness to histamine but not to acetylcholine. (elsevier.com)

Histamine is formed by microbial decarboxylation of histidine. (nofima.no)
Histidine decarboxylase (HDC), found in Escherichia coli , Morganella morganii, and in Proteus and Klebsiella species, converts histidine, present in fish tissue, to histamine. (medscape.com)
Without adequate cooling, these bacteria multiply, increasing the histidine-to-histamine conversion rate and raising histamine levels. (medscape.com)
Toxin production occurs when inadequate refrigeration after the catch allows the multiplication of bacteria that contain histidine decarboxylase, which converts amino acid histidine in the fish tissues to histamine. (medscape.com)
Investigation on beneficial role of l-carnosine in neuroprotective mechanism of ischemic postconditioning in mice: possible role of histidine histamine pathway. (bvsalud.org)
The present study was undertaken to investigate the possible role of histidine - histamine pathway in the neuroprotective effects produced by L-carnosine hand in hand with ischemic postconditioning in the animal model of cerebral ischemia . (bvsalud.org)
It is concluded that L-carnosine exerts neuroprotective effect via involvement of histidine - histamine pathway since the beneficial effects of L-carnosine were abolished by the H2-blocker. (bvsalud.org)

High histamine foods are often aged, fermented, or soured. (verywellhealth.com)

Histamine is released after injury or allergic reaction as part of the body's immune response. (hellodollface.com)
Histamine may lead to Scombroid food poisoning, which resembles allergic reactions. (nofima.no)
Riley and pharmacologist Dr Geoffrey West went on to galvanise this area of study by showing in a notable series of experiments that the mast cell granules are also the main repository of histamine, a key participant in allergic and anaphylactic reactions. (rcpe.ac.uk)
The authors, led by entomologist Zachary DeVries, conclude that the study's findings are "substantial, because exogenous histamine can provoke allergic responses and asthma. (arstechnica.com)
In the pathogenetic mechanism of allergic asthma, histamine is an independent, as it were, decisive factor involved in the occurrence of an allergic (asthmatic) phenomenon. (pedobearpics.com)
In an allergic body, histamine is contained in an abnormally large amount. (pedobearpics.com)
In an allergic organism, even an antipectic substance is formed, antipexin, which prevents the capture of histamine from plasma. (pedobearpics.com)
Symptoms of histamine fish poisoning resemble an acute allergic reaction and usually appear 10-60 minutes after eating contaminated fish. (medscape.com)

The availability of the human H 3 receptor cDNA should greatly aid in the development of chemical and biological reagents, allowing a greater appreciation of the role of histamine in brain function. (aspetjournals.org)

In the end, they found that infested apartments averaged 54 micrograms of histamine per 100 milligrams of dust. (arstechnica.com)
Twenty micrograms of histamine acid phosphate was then injected intradermally at 4, 8, 12 and 24 h. (medicaljournals.se)

Because solar urticaria involves IgE-mediated mast cell degranulation with consequent histamine release, the first line of treatment for this disease consists of long-acting, nonsedating H1-receptor blockers. (medscape.com)
Degranulation means liberation of the contents of the mast cell granules, including histamine. (pharmacology2000.com)
In these injuries caused degranulation as noted above including again histamine release. (pharmacology2000.com)
More recently, the role of mast cell degranulation (which releases histamine, among other things) in triggering migraines has come to light and is a topic of increasing research interest. (thedailyheadache.com)
The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. (kegg.jp)

Tradename for histamine dihydrochloride. (bvsalud.org)

This agent competitively inhibits histamine at the H2 receptor of the gastric parietal cells, resulting in reduced gastric acid secretion, gastric volume, and reduced hydrogen concentrations. (medscape.com)
Ranitidine inhibits histamine stimulation of the H2 receptor in gastric parietal cells, which, in turn, reduces gastric acid secretion, gastric volume, and hydrogen concentrations. (medscape.com)
Under basal conditions, gastrin was shown to be the main regulatory component of the total acid secretion and directly activated the parietal cell rather than by mediating gastric acid secretion through the release of histamine from the enterochromaffin-like cell, although both pathways were active. (warwick.ac.uk)

The term histamine fish poisoning is now considered more appropriate because many cases are from nonscombroid fish. (medscape.com)

Most of the time very little histamine is excreted unchanged because of these metabolic steps. (pharmacology2000.com)
For two to four weeks, the patient should consume as little histamine as possible and keep a symptom diary. (frusano.com)

In contrast, samples of fish that produce poisoning contain histamine levels of at least 20-50 mg per 100 g of fish. (medscape.com)

The histamine response can produce sneezing, itching, hives and watery eyes. (medlineplus.gov)
When this happens, histamine over activates, producing allergy symptoms like sneezing, itchy and watery eyes, and rashes. (verywellhealth.com)

I was diagnosed with having extremely high histamine levels and I blew off the diagnosis because I don't really have allergy symptoms. (hellodollface.com)
When you are exposed to the allergen again, these antibodies release immune system chemicals, such as histamine, that cause allergy symptoms. (rxwiki.com)
Rather than blocking the action of histamine, one of the body's natural chemicals, as a conventional allergy medicine would, this homeopathic remedy works by gently helping our immune system reduce the histamine load on the body without any drowsiness. (zocalopublicsquare.org)

The most well known biogenic amines are the neurotransmitters serotonin, dopamine, and noradrenaline, and histamine, best known for its role in allergies. (ei-resource.org)
These biogenic amines may act as neurotransmitters, be involved in local immune responses (such as the inflammation produced by histamine release), or regulate functions of the gut. (ei-resource.org)

Mast cells release histamine when an allergen is encountered. (medlineplus.gov)
It's called an H3 receptor, and it's there to be a brake and shut off histamine release. (psychiatrictimes.com)
We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H 2 activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release. (researchsquare.com)
The most important mechanism for histamine release is in response to an immunological stimulus. (pharmacology2000.com)
Following local injury, histamine first produces a local vasodilation (reddening of the area) followed by an the release of acute inflammation mediators. (pharmacology2000.com)
Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines. (aspetjournals.org)
BAC caused histamine release by itself at concentrations over 5 microgram/ml. (aspetjournals.org)
Structure-activity relations studies on various members of the BAC family for their ability to inhibit 48/80-induced histamine release indicated that benzyldimethyltridecylammonium chloride was the most potent. (aspetjournals.org)
Histamine release from human leukocytes by anti-gamma E antibodies. (elsevier.com)
The medication a patient regularly takes can also play a role, as some can cause the body to release its own histamine. (frusano.com)
By stabilizing cells that release histamine, it provides anti-inflammatory protection to help resist heart disease and cancer. (naturalnews.com)
Mast Cell Activation syndrome occurs when something causes the mast cells to release abnormal amounts of histamine. (mindbodyfunctionalmedicine.com)
[3] The underlying mechanism involves immunoglobulin E antibodies (IgE), part of the body's immune system, binding to an allergen and then to a receptor on mast cells or basophils where it triggers the release of inflammatory chemicals such as histamine . (mdwiki.org)

If you have allergies, an allergen triggers histamine production. (verywellhealth.com)

The way I understand histamines is like a bucket, you can tolerate so much until the bucket is full and then you begin having symptoms. (hellodollface.com)
A second agent in fish tissues has been theorized to play a role in histamine toxicity because attempts to recreate the symptoms by orally feeding people histamine have failed. (medscape.com)
7 Ten years on, these children are reported to be at least twice as likely to have asthma symptoms as matched controls and have increased incidence of bronchial lability as measured by exercise or histamine challenge tests. (bmj.com)

The covalent agonists are derived from the monoamine neurotransmitters noradrenaline, dopamine, serotonin, and histamine, and they were accessed using a general and versatile synthetic strategy. (rcsb.org)

abstract = "The production of large quantities of the lymphokine(s) histamine-releasing activity (HRA) and its partial purification by Sephadex G-75 and ion-exchange chromatography on carboxymethyl (CM) Sepharose 6B have been detailed (M. A. Lett-Brown, D. O. Thueson, D. E. Plank, M. P. Langford, and J. A. Grant, Cell. (utmb.edu)

Histamine toxicity is a form of food poisoning called scombroid poisoning that occurs from eating spoiled fish. (verywellhealth.com)
Previous terms for histamine fish poisoning were scombroid fish poisoning, pseudoallergic fish poisoning, histamine overdose, or mahi-mahi flush. (medscape.com)

Body Ecology Histamine Reducing Probiotic Powder is a blend of beneficial bacteria that support the DAO enzyme and helps to lower high levels of mast cells in the gut. (bodyecology.com)
This comprehensive blend is especially for individuals wanting to optimize effectiveness of a histamine-free probiotic bacteria on their intestinal flora. (bodyecology.com)

Histamine Modulation is associated with the inflammatory responses. (pharmacology2000.com)
As the creepy critters bite you while you slumber, they also squeeze out poops loaded with histamine, a chemical that our own bodies push out during an inflammatory response to allergens. (arstechnica.com)
Histamine is a potent pro-inflammatory mediator that is principally released from mast cells. (guidetopharmacology.org)

Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. (bvsalud.org)

The DAO enzyme in our Histamine Reducing Probiotic Powder is responsible for breaking down histamine in the intestines. (bodyecology.com)
The enzyme diamine oxidase (DAO) is what breaks down the histamines but in some people, like me, are deficient in it. (hellodollface.com)
Apart from provocation testing, it is possible to measure DAO enzyme activity in the blood, which can affect histamine levels. (frusano.com)

Objectives: To evaluate the efficacy of nizatidine, a histamine H2-blocking drug, in delaying the progression of cognitive impairment in older adults with Alzheimer disease (AD). (usu.edu)

Alpha 1-adrenergic and H1-histamine receptor control of intracellular Ca2+ in a muscle cell line: the influence of prior agonist exposure on receptor responsiveness. (semanticscholar.org)
5. During the refractory period after methacholine desensitization, muscle strips were still responsive to 40 mM KCl but did not contract in response to 10 mM caffeine, suggesting that the heterologous desensitization is caused by a modification of an intracellular Ca2(+)-store, which is used by both histamine and methacholine. (vu.nl)

Histamine is active biologically, but the first step for its inactivation involves the addition of a methyl group (CH 3 ) followed by a chemical oxidation. (pharmacology2000.com)
This putative second causative agent, possibly saurine (histamine hydrochloride), may enhance the activity of histamine, facilitate its absorption, or prevent its inactivation by histamine N- methyltransferase or diamine oxidase. (medscape.com)

Histamine deficiency promotes inflammation-associated carcinogenesis t" by Xiang Dong Yang, Walden Ai et al. (uwo.ca)

Histamine Receptor Blockade in the Treatment of Alzheimer's Disease: " by Michelle C. Carlson, JoAnn T. Tschanz et al. (usu.edu)

Together, these data have been interpreted as indicating that this increased survival pattern is due to an off-target, non-histamine receptor-mediated property of famotidine that is not shared with cimetidine. (researchsquare.com)
The most likely mechanisms of actions include: via antiviral activity, via novel human targets, or via the on-target mechanism described in the current FDA market authorization - famotidine is a histamine receptor H 2 antagonist (and inverse agonist). (researchsquare.com)

Over the last couple of years, medication and diet have established that histamine is a major migraine trigger for me. (thedailyheadache.com)

Since its first pharmacological description as an endogenous substance in 1910 ( Barger and Dale, 1910 ), histamine has proven to exert tremendous influence over a variety of physiological processes. (aspetjournals.org)
When this happens, the eyes produce a substance called histamine which can cause you to feel a gritty feeling in your eyes as well as burning, itching, swelling, redness, and tearing. (medium.com)

An example of a typical histamine toxicity rash, in this case from tuna. (medscape.com)

It has been suggested that the histamine subtype 3 receptor inverse agonists such as MK-0249 might be effective in treating attention-deficit/hyperactivity disorder (ADHD). (psychiatrist.com)

Transdermal histamine offers promise, and adenosine monophosphate may sometimes benefit. (altmedrev.com)

Results suggest that NO that was presumably derived from the sympathetic nervous system regulates airway responsiveness to histamine in guinea pigs. (elsevier.com)

Histamine is a chemical in the body that acts as a messenger in the immune system . (verywellhealth.com)
Body Ecology's Histamine Reducing Probiotic is a high-quantity blend of 6 highly potent probiotic strains, formulated to maximize health benefits and maintain a well-balanced immune system. (bodyecology.com)

It was a Trigger, my histamine levels shoot up, and although I didn't swell up, I felt vertigo, blood pressure drop, heart rate up, dizzy, a pressure in my jaw, face, my body temperature inside was changing from cold to hot. (thehealthyapple.com)

The calcium dependence of potassium chloride-, prostaglandin F2 alpha (PGF2 alpha)-, and histamine-induced contractions of human chorionic vasculature segments was investigated. (semanticscholar.org)

Sgnificant histamine is excreted unchanged in the presence of these diseases: (a) systemic mastocytosis, (b) gastric carcinoid syndrome or (c) urticaria pigmentosa. (pharmacology2000.com)
Histamine is known as a regulator of gastrointestinal functions, such as gastric acid production, intestinal motility, and mucosal ion secretion. (bmj.com)

Asthma endophenotypes and polymorphisms in the histamine receptor HRH4 gene. (cdc.gov)

Genetic Variation in the Histamine Production, Response, and Degradation Pathway Is Associated with Histamine Pharmacodynamic Response in Children with Asthma. (cdc.gov)
Genetic variation within the histamine pathway among patients with asthma--a pilot study. (cdc.gov)

We utilized a novel dual-sensing approach, where an iridium oxide sensor was used to monitor pH and a boron-doped diamond electrode was used for the detection of histamine from in vitro guinea pig stomach mucosal sections. (warwick.ac.uk)

2. Histamine H1-receptor-mediated contractions appear to be rapidly reduced after application of 100 microM histamine. (vu.nl)
3. Initial contractions to 0.3 microM histamine were reduced by 90%, recovered quickly, but did not reach control levels within 1 h. (vu.nl)
7. The protein kinase C activator, phorbol-12,13-dibutyrate, concentration-dependently inhibited histamine- and methacholine-induced contractions. (vu.nl)

This article explains foods with high levels of histamines and how to eat a low-histamine diet. (verywellhealth.com)
Aged cheeses have the highest levels of histamine. (verywellhealth.com)
I just bought a supplement called UmbrellexDAO to help with my histamine levels as well as Quercetin. (hellodollface.com)
When histamine levels get too high or when histamine cannot break down properly, it can affect your normal bodily functions. (hellodollface.com)
Going on a low-histamine, low carb diet is what I am doing right now as well as taking the UmbrellexDAO and quercetin, I also watch oxalate levels and consume high oxalate foods sparingly. (hellodollface.com)
Recovery experiments showed that the recovery of histamine is good, between 97.7 and 102 %, for all tested sample matrixes and concentration levels (approximately 2-180 mg/kg). (nofima.no)
Histamine levels in infested homes were 20X higher than normal. (arstechnica.com)
The researchers found that histamine levels in infested homes were at least 20-times higher than levels in bed-bug free homes. (arstechnica.com)
Researchers writing in PLOS ONE also found that those histamine levels linger. (arstechnica.com)
In infested homes that were heat treated-which involves circulating hot air (~50 ̊C) into a home to wipe out the bugs-histamine levels remained high for months afterward. (arstechnica.com)
To begin to answer the question, they set out to see if histamine levels are even a measurable problem in infested houses. (arstechnica.com)
They also noted that heat treatments did not significantly flush histamine levels in the subsequent 12 weeks. (arstechnica.com)
Under stimulated conditions with ACh, the gastrin and histamine components of the total acid secretion were not altered compared with levels observed under basal conditions, suggestive that ACh had no direct effect on the enterochromaffin-like cell and G cell. (warwick.ac.uk)
Clinical evidence as far back as the early 80s supports this notion, with research showing migraineurs have increased levels of histamine in their blood and in studying the role of antihistamines in migraine prevention. (thedailyheadache.com)
If confirmation is required, histamine levels in uneaten portions of the suspect fish can be measured. (medscape.com)
In addition, elevated histamine levels can be measured in patients' urine. (medscape.com)
In healthy fish, histamine is normally present at levels less than 0.1 mg per 100 g. (medscape.com)

Anatomy15

Organisms2

Diseases9

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes9

Major changes in the brain histamine system of the ground squirrel Citellus lateralis during hibernation. (1/3980)

Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea. (2/3980)

Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. (3/3980)

Dynamic and quantitative Ca2+ measurements using improved cameleons. (4/3980)

On the mechanism of histaminergic inhibition of glutamate release in the rat dentate gyrus. (5/3980)

Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. (6/3980)

Exhaled nitric oxide; relationship to clinicophysiological markers of asthma severity. (7/3980)

Strain-dependent induction of allergic sensitization caused by peanut allergen DNA immunization in mice. (8/3980)

Histamine

Receptors, Histamine H1

Histamine Release

Receptors, Histamine H2

Receptors, Histamine

Histamine Antagonists

Histamine Agonists

Histamine H1 Antagonists

Receptors, Histamine H3

Histamine H2 Antagonists

Histamine N-Methyltransferase

Pyrilamine

Methylhistamines

Histidine Decarboxylase

Dimaprit

Histamine H3 Antagonists

Histamine Agents

Cimetidine

Chlorpheniramine

Metiamide

Diphenhydramine

Mast Cells

p-Methoxy-N-methylphenethylamine

Basophils

Impromidine

Thiourea

Guinea Pigs

Anaphylaxis

Burimamide

Histamine H1 Antagonists, Non-Sedating

Bronchial Provocation Tests

Ranitidine

Triprolidine

Immunoglobulin E

Cromolyn Sodium

Pruritus

Terfenadine

Dose-Response Relationship, Drug

Famotidine

Amine Oxidase (Copper-Containing)

Gastric Juice

Gastric Mucosa

SRS-A

Gastric Acid

Cetirizine

Methacholine Compounds

Pentagastrin

Ketotifen

Tripelennamine

Bronchi

Anti-Allergic Agents

Muscle, Smooth

Airway Resistance

Bronchoconstriction

Trachea

Enterochromaffin-like Cells

Methylhistidines

Passive Cutaneous Anaphylaxis

Gastrins

Serotonin

Piperidines

Mucuna

Stomach

Muscle Contraction

Nasal Provocation Tests

Capillary Permeability

Bronchial Spasm

Bradykinin

Imidazoles

Stimulation, Chemical

Asthma

Hypersensitivity

Gastric Fistula

Parietal Cells, Gastric

Hypersensitivity, Immediate

Clemastine

Enterochromaffin Cells

Atropine

Urticaria

Cells, Cultured