A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
Conditions with abnormally low levels of ALPHA-LIPOPROTEINS (high-density lipoproteins) in the blood. Hypoalphalipoproteinemia can be associated with mutations in genes encoding APOLIPOPROTEIN A-I; LECITHIN CHOLESTEROL ACYLTRANSFERASE; and ATP-BINDING CASSETTE TRANSPORTERS.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
The sum of the weight of all the atoms in a molecule.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.
The application of repeated, brief periods of vascular occlusion at the onset of REPERFUSION to reduce REPERFUSION INJURY that follows a prolonged ischemic event. The techniques are similar to ISCHEMIC PRECONDITIONING but the time of application is after the ischemic event instead of before.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Solutions which, upon administration, will temporarily arrest cardiac activity. They are used in the performance of heart surgery.
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The circulation of blood through the CORONARY VESSELS of the HEART.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Cell adhesion molecule and CD antigen that mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
The hollow, muscular organ that maintains the circulation of the blood.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Contractile activity of the MYOCARDIUM.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Elements of limited time intervals, contributing to particular results or situations.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Surgical removal of an obstructing clot or foreign material from a blood vessel at the point of its formation. Removal of a clot arising from a distant site is called EMBOLECTOMY.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.
The removal of secretions, gas or fluid from hollow or tubular organs or cavities by means of a tube and a device that acts on negative pressure.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
The valve between the left atrium and left ventricle of the heart.
The dormant state in which some warm-blooded animal species pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs.
The family of carnivorous or omnivorous bears, having massive bodies, coarse heavy fur, relatively short limbs, and almost rudimentary tails.
A phylum of gram-negative bacteria containing seven class-level groups from a wide variety of environments. Most members are chemoheterotrophs.
Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions.
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
A beverage made from ground COFFEA beans (SEEDS) infused in hot water. It generally contains CAFFEINE and THEOPHYLLINE unless it is decaffeinated.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
Drinkable liquids combined with or impregnated with carbon dioxide.
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.
A country spanning from central Asia to the Pacific Ocean.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Bears exhibited largely the active high-molecular weight (HMW) versus the low-molecular weight isoforms of myocardial ... In both dogs and bears, myocardial adiponectin was expressed independent of circulating adiponectin concentrations, suggesting ... Serum adiponectin levels are often conflicting, with higher levels associated with poor survival in humans with congestive ... In humans with dilated cardiomyopathy, myocardial adiponectin protein expression is reduced compared to normal hearts and has ...
T. Inoue, N. Kotooka, T. Morooka et al., "High molecular weight adiponectin as a predictor of long-term clinical outcome in ... R. Shibata, K. Sato, D. R. Pimentel et al., "Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- ... "Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes," American Journal of Physiology- ... L. Tao, E. Gao, X. Jiao et al., "Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of ...
T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A. 2004; ... Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med. 2005 ... Selective downregulation of the high molecular weight form (HMW) of adiponectin in hyperinsulinemia and in type 2 diabetes: ... APN indicates adiponectin; Cav3, caveolin-3; iNOS, inducible nitric oxide synthase; MI/R, myocardial ischemia/reperfusion; WT, ...
2007 May;20(5):565-72 - There was a significant increase in high molecular weight adiponectin in the telmisartan group ... The ... 2011 Nov 3 - myocardial ischemia/reperfusion (I/R) injury ... Telmisartan reduced the extension of the infarct size in a dose- ... Telmisartan at 80 mg/Day Increases High-Molecular-Weight Adiponectin Levels and Improves Insulin Resistance in Diabetic ... Body weight was significantly higher in SHR-HF (368 +/- 5 g) compared to SHR-NF (328 +/- 7 g). Telmisartan but not valsartan ...
Synergistic effects of ascorbic acid and thiazolidinedione on secretion of high molecular weight adiponectin from human ... of High-dose Vitamin C on Oxygen Free Radical Production and Myocardial Enzyme after Tourniquet Ischaemia-Reperfusion Injury ... adiponectin. Similar results were seen in cells co-treated with TNFα - See my adiponectin page. High adiponectin is a good ... Lower Adiponectin Levels at First Trimester of Pregnancy Are Associated With Increased Insulin Resistance and Higher Risk of ...
Open Access journal that publishes original research and review articles on the molecular basis, cell biology and pharmacology ... of inflammation, including acute/chronic inflammation, mediators of inflammation, as well as cellular processes and molecular ... R. Shibata, K. Sato, D. R. Pimentel et al., "Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- ... and high-molecular weight. Adiponectin shares sequence homology with collagens VIII and X as well as complement factor C1q. It ...
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms ... Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and ... Association of ADIPOQ variants, total and high in patients with type 2 diabetes. Diabetes. 2006;55:1512-6. molecular weight ... Association of ADIPOQ variants, total and high in patients with type 2 diabetes. Diabetes. 2006;55:1512-6. molecular weight ...
The oligomeric structure of high molecular weight adiponectin. FEBS Lett. 2007; 581: 809-814. ... Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med. 2005 ... Adiponectin levels in serum are 1000-fold higher than many growth factors and cytokines. Thus, it is difficult to understand ... Because of its high abundance, it is conceivable that adiponectin possesses another function that involves low affinity ...
Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over the past 15 years. A multitude of ... Zhu N, Pankow JS, Ballantyne CM et al (2010) High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC ... Shibata R, Sato K, Pimentel DR et al (2005) Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- ... Hara K, Horikoshi M, Yamauchi T et al (2006) Measurement of the high-molecular weight form of adiponectin in plasma is useful ...
Ischaemia and protection: Platelet serotonin aggravates myocardial reperfusion injury via degranulation. *Dr. Anna Reid. ... Direct comparison of four very early rule-out strategies for acute myocardial infarction using high-sensitivity cardiac ... Lifestyle and blood pressure: The impact of obesity and diet-induced weight loss on non-dippers and circadian BP patterns ... Cellular and molecular electrophysiology: Local epicardial light pulse terminates ventricular arrhythmias in the adult rat ...
Increase in high molecular weight adiponectin by bariatric surgery-induced weight loss. Diabetes, Obesity and Metabolism, 10(2 ... Erythropoietin protects from reperfusion-induced myocardial injury by enhancing coronary endothelial nitric oxide production. ... Thiersch, Markus; Swenson, Erik R (2018). High altitude and cancer mortality. High Altitude Medicine & Biology, 19(2):116-123. ... Chronic central infusion of amylin lowers body weight gain independent of initial body weight in chow fed rats but not in rats ...
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med. 2005 ... the ratio of LV plus septal weight to body weight, and the ratio of RV weight to body weight among all groups (the Table). ... Cardiac Molecular Parameters To assess the molecular basis of the improvement in cardiac performance achieved by metformin ... We need to consider the dose of metformin used in the present study, which was at least 3-fold higher than that used clinically ...
Global ischemia for 30 minutes followed by reperfusion for 120 minutes was employed to produce myocardial injury. Myocardial ... The hypothetical trigger of remote postconditioning (RPost) of the heart is the highmolecular weight hydrophobic peptide(s). ... It was established that oxidative stress induces a decrease in adiponectin production by adipocytes. It has also been shown ... However, the underlying cellular and molecular mechanisms of CIHH treatment improving energy metabolism in cardiomyocytes are ...
Another study demonstrates that in 9-week-old mice fed a high-fat diet, serum and myocardial ET-1, myocardial leptin, and Ob-R ... Protection in Ischemia/Reperfusion Injury. Timely reperfusion is necessary to salvage myocardium from acute infarction, but ... In C57BL/6J mice fed a 10-week high-fat diet, intraperitoneal leptin administration failed to decrease appetite and body weight ... Molecular and anatomical determinants of central leptin resistance. Nat Neurosci. 2005; 8: 566-570. ...
Myocardial Infarction (MI) is the most common cardiovascular disease. An average-sized MI causes the loss of up to 1 billion ... Myocardial Infarction (MI) is the most common cardiovascular disease. An average-sized MI causes the loss of up to 1 billion ... High, but not low, molecular weight hyaluronan prevents T-cell-mediated liver injury by reducing proinflammatory cytokines in ... TNF-α antagonism ameliorates myocardial ischemia-reperfusion injury in mice by upregulating adiponectin. Am J Physiol Heart ...
Heart weight, body weight, abdominal-fat weight, total cholesterol level and fasting blood glucose were higher in obesity than ... HO-1 and NQO1 are markedly deceased in acute lung and kidney ischemia-reperfusion injury [36, 37]. These two anti-oxidant ... Proposed molecular-cellular factors underlying the effects of obesity control (i.e., body weight reduction) on heart function ... Levels and values of serum high-sensitivity C-reactive protein within 6 hours after the onset of acute myocardial infarction. ...
Vinten-Johansen J. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res 2004; ... higher perforin levels and more than three-fold higher CD40 ligand, accounting for their higher cytotoxicity 116. In CD4+ T- ... Adiponectin. Adiponectin is the most abundant of all circulating adipokines, and is exclusively produced by adipose tissue. It ... Although the nature of this association is not clear, gaining weight aggravates the severity of OSAHS, while drastic weight ...
We previously found that myocardial ischemia/reperfusion (I/R) initiates expression of tumor necrosis factor-alpha (TNF) ... Direct relationship between levels of TNF-alpha expression and endothelial dysfunction in reperfusion injury. ... Expression of Grb10 was increased in islets isolated from rats fed a high-fat plus high-sugar diet compared with islets ... The VLCD caused a weight loss of -8.7 ± 0.6?kg (mean?±?standard error (SE), P < 0.0001) combined with a significant improvement ...
AdipoR1, adiponectin, Ob-R, leptin, COX-1, COX-2, aromatase, PGF(2a), F-2-isoprostanes and alpha-SMA were localised on higher ... Ischaemia-reperfusion injury resulting from interruption and restoration of blood flow might be related to free radical ... Compared with SFA intake, n-6 PUFAs reduce liver fat and modestly improve metabolic status, without weight loss. A high n-6 ... Also, a likely beneficial effect upon myocardial injury was noticed. Although none of the genes known to be involved in ...
Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular ... an appreciable increase in the high-molecular-weight form of Fstl1 could be detected in mouse serum after myocardial infarction ... The expression of Fstl1 protein (both the high- and low-molecular-weight forms) was increased in heart by Akt transgene ... Figure 8. Fstl1 protects against myocardial ischemia/reperfusion injury in vivo. A, Western blot analysis of serum proteins ...
increased birth weight*heterozygous fetuses carried by wild-type dams exhibit a 5% higher birth weight than wild-type ... Peripheral neuropathy and myocardial disease are seen in C57BLKS Leprdb homozygotes. Wound healing is delayed and metabolic ... Molecular Note. An intronic G-to-T transversion in this allele created a donor splice site that causes abnormal splicing and ... homozygotes subjected to 30, 45, and 60 min of left coronary artery ischemia-reperfusion exhibit survival rates of 71%, 53%, ...
Am J Physiol Heart Circ Ouchi N, Walsh K. Adiponectin protects against myocardial ischemia- reperfusion injury through AMPK- ... high molecular weight (HMW) adiponectin. Although there erages, of questionable nutritional value. According to a is no ... Low levels of adiponectin are novirus, and recombinant adiponectin infusion prior to orduring the ischaemia-reperfusion ... tin or, alternatively, a higher ratio of inert adiponectincomplexes, despite high levels of total plasma adiponectin.. Future ...
Body weight, blood glucose, triglycerides (TGs), total cholesterol (TC), urea nitrogen (UN), creatinine (Cr), and microalbumin/ ... Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms ... Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling. Exp Ther Med. ... Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth ...
Role of adiponectin in diabetes myocardial ischemia-reperfusion injury and ischemic postconditioning ... Relative molecular weight of the target protein was detected by SDS-PAGE electrophoresis. The CARD9-MBP fusion protein was ... MXF had good therapeutic effects on the abnormity of body weight, rectal temperature, lung index and high mortality rate of ... Methods Diabetic rats were subjected to I/R injury (30 min of LAD occlusion followed by 120 min of reperfusion). Myocardial ...
High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease. Am J ... Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010;4(3):214-222.. View this article ... T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci USA. 2004;101( ... Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure. Eur Heart J. ...
Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease. Circ J. 2008 ... Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular ... Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med. 2005 ... Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res. 2004; 94: e27- ...
... most studies available suggest a higher incidence and severity of acute kidney injury in obese patients when compared with lean ... effects during kidney I/R injury were reported. Consequently, assessment of overall or high-molecular-weight adiponectin ... Impact of a single intracoronary administration of adiponectin on myocardial ischemia/reperfusion injury in a pig model. Circ ... Protective effects of adiponectin against renal ischemia-reperfusion injury via prostacyclin-PPARα-heme oxygenase-1 signaling ...
Regulation and actions of activin A and follistatin in myocardial ischaemia-reperfusion injury. Cytokine 2014;69:255-62.. 80. ... High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress- ... Molecular understanding of hyperglycemias adverse effects for diabetic complications. JAMA. 2002;288:2579-88.. 34. Asahara T, ... Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes. 2003;52:239-43. ...
... while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin ... On the other hand, there are many clinical cases where the loss of skeletal muscle due to a traumatic injury, an aggressive ... Recovery from AMI and reperfusion is still less than ideal. Stem cell therapy may represent a valid treatment. However, ... integrate into the myocardium because they are not subjected to the mechanical forces that are known to drive myocardial ...
In this study, we investigated the anti-myocardial ischemia and reperfusion (I/R) injury effects of ND01 in vivo and elucidated ... The standard medical treatment includes heparin or low molecular weight heparin in the hospital, antiplatelet agents in the ... A higher rate of hospitalizations determines higher mortality. The most reliable way to decrease admissions is to monitor for ... similar to adiponectin. The aim of the present study was to determine whether CTRP3 may regulate postischemic cardiac ...
  • In a mouse model of acute MI, adiponectin with males, obese subjects vs. lean subjects, and type 2 null mice responded with larger infarct sizes, greater myo- diabetics vs. non-diabetics. (pdfmedarticles.com)
  • The obesity paradox and acute kidney injury: beneficial effects of hyper-inflammation? (biomedcentral.com)
  • The study is discussed in the context of the controversial findings that, in contrast to the existing literature on improved survival, most studies available suggest a higher incidence and severity of acute kidney injury in obese patients when compared with lean controls. (biomedcentral.com)
  • Acute coronary syndromes (ACS) cause cessation of myocardial blood flow leading to coronary ischemia. (biomedsearch.com)
  • In cardiopulmonary bypass-induced acute renal injury and cisplatin-induced nephrotoxic injury, increased de novo synthesis of LCN2 in proximal tubule cells leads to sharply increased concentration of this protein in both urine and serum. (biovendor.com)
  • We have also been able to correlate better adherence to guidelines within a hospital to improved outcome in patients with acute myocardial infarction. (slideshare.net)
  • We investigated whether microdialysis results obtained from epicardial (surface) sampling reflect acute changes in the same way as myocardial sampling from within the substance of the ventricular wall. (diva-portal.org)
  • This study aimed to evaluate the impact of DPP-4 inhibitors on the survival of diabetic patients after first acute myocardial infarction (AMI). (biomedcentral.com)
  • This study aimed to evaluate the impact of DPP-4i on survival of diabetic patients after first acute myocardial infarction (AMI) through analysis of the data from the Taiwan National Health Insurance Research Database. (biomedcentral.com)
  • Acute kidney injury (AKI) is a common complication in COVID-19 patients 7 . (randox.com)
  • The National Institute of Care Excellence (NICE), have set out four guidelines for acute kidney injury in hospitalised suspected or confirmed COVID-19 patients and highlights the importance of creatinine testing 9 . (randox.com)
  • The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction. (biomedsearch.com)
  • We investigated the influence of mBMC on circulating levels of MMP-9, TIMP-1, and EMMPRIN at different time points in patients included in the randomized Autologous Stem-Cell Transplantation in Acute Myocardial Infarction (ASTAMI) trial (n = 100). (biomedsearch.com)
  • The early and late mortality after acute myocardial infarction (AMI) is declining, but cardiovascular disease (CVD) is still one of the leading causes of morbidity and death in the Western world. (biomedsearch.com)
  • Acute myocardial infarction (AMI) is an acute disease with high mortality and seriously threatens human health. (amegroups.com)
  • Acute myocardial infarction (AMI) is a myocardial necrosis caused by acute and persistent ischemia and hypoxia of the coronary artery. (amegroups.com)
  • Patients with definite diagnosis of acute myocardial infarction (AMI) were excluded. (bvsalud.org)
  • Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. (mdc-berlin.de)
  • Dazomet when given for prolonged periods in high doses has been associated with elevations in serum enzyme levels, and rare instances of acute, clinically apparent liver injury have been linked to its use. (storysteel.cf)
  • The study was to evaluate the roles of Adiponectin (ADP) in alleviating myocardial ischemia-reperfusion injury in rats with Remote Ischemic Postconditioning (RIP). (alliedacademies.org)
  • ADP is involved in RIP that can alleviate the myocardial ischemia-reperfusion injury in rats. (alliedacademies.org)
  • The larger adipocytes found in obese subjects produce lower levels of adiponectin but higher levels of proinflammatory cytokines, such as TNF α [ 7 ]. (hindawi.com)
  • Given that the levels of adiponectin vary in different inflammatory diseases as discussed above, these data suggest that the metabolic consequences observed in obesity may be related to an imbalance of pro- and anti-inflammatory cytokines. (hindawi.com)
  • Keywords: ADIPOQ, Single nucleotide polymorphisms, Cardiovascular disease, Association, Meta-analysis Background Adiponectin is involved in CVD: low levels of adipo- Cardiovascular disease (CVD) is the primary cause of nectin (hypoadipoectinemia) positively correlate with the death worldwide, leading to 32% of all deaths worldwide risk of CVD, and higher levels of adiponectin protect in 2013 [1]. (deepdyve.com)
  • Low levels of adiponectin are novirus, and recombinant adiponectin infusion prior to orduring the ischaemia-reperfusion procedure, amelioratedall the associated damaging effects,9 suggesting that The opinions expressed in this article are not necessarily those of the exogenous adiponectin protects the heart against ischaemic Editors of the European Heart Journal or of the European Society ofCardiology. (pdfmedarticles.com)
  • Therefore, low levels of adiponectin are associated with a higher risk for diabetes and cardiovascular disease. (biomedcentral.com)
  • The effects of leptin on the cardiovascular system are discussed in detail, including its contributions to hypertension, atherosclerosis, depressed myocardial contractile function, fatty acid metabolism, hypertrophic remodeling, and reduction of ischemic/reperfusion injury. (ahajournals.org)
  • 9 Leptin treatment reduced her weight to the normal range for her age, and the same effects were observed in her similarly affected cousin. (ahajournals.org)
  • 14 The failure of leptin to induce weight loss in these cases is thought to be the result of leptin resistance. (ahajournals.org)
  • Adipose tissue also produces a variety of secreted factors called adipocytokines, including leptin and adiponectin. (jci.org)
  • This is due largely to their secretory profile of adipokines such as leptin, adiponectin, hepatocyte growth factor, collagen VI, interleukin 6, and tumor necrosis factor α ( 3 ). (aacrjournals.org)
  • We measured superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, total antioxidant capacity (TAC), and levels of 8-iso-prostaglandin F2α (8-iso-PGF2α), adiponectin, leptin, and resistin in 63 diabetic patients with hyperglycemic crises. (springer.com)
  • Adiponectin, leptin, and resistin are known adipokines. (springer.com)
  • In contrast to other adipokines, serum adiponectin is inversely related to visceral obesity in humans [ 1 , 8 ]. (mdpi.com)
  • Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects," Arteriosclerosis, Thrombosis, and Vascular Biology , vol. 27, no. 9, pp. 1918-1925, 2007. (hindawi.com)
  • Low adiponectin levels are inversely related to high levels of C-reactive protein (CRP) in patients with obesity, type 2 diabetes, and CAD [ 13 - 15 ]. (hindawi.com)
  • Thus, adiponectin mediates protective effects in obesity-related metabolic and vascular disease presumably by its anti-inflammatory actions and protects the heart against ischemia-reperfusion injury through its ability to suppress myocardial inflammation and apoptosis [ 23 ]. (hindawi.com)
  • 2,3 High levels of CRP are also associated with obesity and coronary heart disease, 4,5 suggesting that CRP is a useful biomarker for obesity-linked chronic inflammatory states. (ahajournals.org)
  • Low plasma adiponectin levels, also known as hypoadiponectinemia, are closely associated with the increased prevalence of obesity-linked disorders including type 2 diabetes, coronary heart disease, and hypertension. (ahajournals.org)
  • 14 Thus, adiponectin exerts beneficial actions on the obesity-related metabolic and cardiovascular complications, at least in part, through its ability to control inflammatory responses. (ahajournals.org)
  • Inhibition of vascular c-Jun N-terminal kinase 2 improves obesity-induced endothelial dysfunction after Roux-en-Y gastric bypass. (uzh.ch)
  • The widely distributed Ob-Rs make the hormone an attractive candidate for a molecular link in the pathogenesis of obesity-related diseases. (ahajournals.org)
  • on page 2300 Cavusoglu et al.6 reported on a 2-year study that included Once considered a disease of the affluent, obesity now pre- 325 high-risk males with cardiac-related chest pain and under- vails in the poorer developing nations as well.1 Although it is went coronary angiography. (pdfmedarticles.com)
  • Elevated circulating adiponectin widely acknowledged that obesity, together with its allied levels at presentation were found to be independent metabolic disorders, is closely associated with the patho- markers of both myocardial infarction (MI) and all-cause mor- genesis of cardiovascular diseases (CVDs),1,2 the precise tality at 2 years, challenging the accumulated cellular, molecular links between obesity and CVD remain speculat- animal, and human epidemiological data that support adipo- ive. (pdfmedarticles.com)
  • Adiponectin is known to be a pleiotropic organ-protective protein that is exclusively produced by adipocytes and decreased in obesity. (jci.org)
  • While anthropometric measurements of weight-for-height have been traditionally used to evaluate obesity, more recently, BMI has become a standard parameter. (pubmedcentralcanada.ca)
  • The molecular mechanisms linking obesity and adipocytes to increased arrhythmogenicity in both the atria and ventricles remain poorly understood. (frontiersin.org)
  • By better understanding the molecular mechanisms connecting dysfunctional adipocytes and arrhythmias, novel therapies may be developed to sever the link between obesity and arrhythmias. (frontiersin.org)
  • High serum fasting peptide YY (3-36) is associated with obesity-associated insulin resistance and type 2 diabetes. (oulu.fi)
  • Obesity and its complications lead to vascular injury, atherosclerosis, diabetes and pathological angiogenesis. (biomedcentral.com)
  • At the root of many age-related chronic conditions lies the cluster of disorders known as the metabolic syndrome, which includes insulin resistance, obesity, elevated triglycerides, low high-density lipoprotein (HDL), and hypertension. (prohealth.com)
  • In humans with dilated cardiomyopathy, myocardial adiponectin protein expression is reduced compared to normal hearts and has been implicated in the pathology of cardiomyopathy. (mdpi.com)
  • We evaluated adiponectin serum concentrations and myocardial protein expression in dogs with naturally occurring myxomatous mitral valve disease and CHF. (mdpi.com)
  • Finally, pharmacological activation of both AMPK plus protein kinase A significantly reduced myocardial infarct size and improved cardiac function in Cav-3KO animals. (ahajournals.org)
  • In contrast, adiponectin, also referred to as adipocyte complement-related protein 30 (ACRP30), is an antiinflammatory adipokine that is abundantly present in blood stream. (ahajournals.org)
  • Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over the past 15 years. (springer.com)
  • Background- Some studies have shown that metformin activates AMP-activated protein kinase (AMPK) and has a potent cardioprotective effect against ischemia/reperfusion injury. (ahajournals.org)
  • MicroRNAs, Akt, the phosphate and tension homology deleted on chromosome 10 protein (PTEN), pyruvate dehydrogenase and sirtuin-1 reportedly modulate inflammation in cardiomyocytes during I/R. Cryopyrin and caspase-1/4 inhibitors are reported to increase cardiac tolerance to ischemic and reperfusion cardiac injury, presumably by suppressing inflammasome-dependent inflammation. (bvsalud.org)
  • The serine/threonine protein kinase Akt is a key regulator of myocardial growth that is essential for cardiac adaptation to diverse stress. (ahajournals.org)
  • Only C-reactive protein (CRP),2 a recognized ecules, complement factors, growth factors, and signalling inflammatory factor, and adiponectin persistently and inde- proteins2 that modulate inflammatory, metabolic, and cardio- pendently transpired as risk factors for MI and mortality, regardless of further statistical adjustments. (pdfmedarticles.com)
  • Adiponectin is an adipocyte-specific protein that circulates A similar correlation of adiponectin levels with cardiovas- in concentrations greater than any other hormone in the cular mortality was also evident in patients with congestive body. (pdfmedarticles.com)
  • The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. (doabooks.org)
  • We administered candesartan therapy (12 mg daily) for 6 months and evaluated whether there was improvement in serum inflammatory parameters high molecular weight adiponectin (HMW-ADN), plasminogen activator inhibitor-1 (PAI-1), highly sensitive C-reactive protein (Hs-CRP), vascular cell adhesion molecule-1 (VCAM-1) in serum and urinary-8-hydroxydeoxyguanosine (U-8-OHdG). (springermedizin.de)
  • Clq/TNF-Related Protein 9 Protects Diabetic Rat Heart against Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress. (thefreelibrary.com)
  • Today it is generally accepted that B cells require cognate relationships with Compact disc4+ T cells to build up high-affinity antibodies against protein. (world-of-links.com)
  • Adiponectin, an adipose-specific protein, is negatively correlated with pro-atherogenic low-density lipoprotein cholesterol (LDL-C) and other cardiovascular risk factors such as insulin resistance. (biomedcentral.com)
  • Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study. (lifeextensionvitamins.com)
  • In mice fed a high-cholesterol diet, adipose tissue macrophage (ATM) infiltration and M1-to-M2 ratio were decreased in ATIP1 transgenic mice (ATIP1-Tg) compared with wild-type mice (WT), with decreased expression of inflammatory cytokines such as tumor necrosis factor-α and monocyte chemoattractant protein-1 in white adipose tissue (WAT), but an increase in interleukin-10, an anti-inflammatory cytokine. (pubmedcentralcanada.ca)
  • By contrast, there was a decrease of 19 proteins, such as adiponectin (ADIPOQ ratio =0.70), insulin-like growth factor binding protein6 (IGFBP6 ratio =0.70), Dickkopf-related protein 3 (DKK3 ratio =0.70) and complement 4B (C4B ratio =0.68). (amegroups.com)
  • Adiponectin (ADP) is one adipose cell-derived hormone protein secreted by the adipose tissue, abundant in human plasma, and can be expressed in the bone marrow, osteoblasts, cardiomyocytes, etc. (alliedacademies.org)
  • S100 calcium binding protein B (S100B) has been found to be useful in detection of CNS injury and hence can be used to avoid unnecessary radiation to patients in the form of CT scans. (intechopen.com)
  • Renoprotection of adiponectin is associated with improvement of the endothelial dysfunction, reduction of oxidative stress, and upregulation of endothelial nitric oxide synthase expression through activation of adenosine 5'-monophosphate-activated protein kinase by AdipoR1 and activation of peroxisome proliferator-activated receptor (PPAR)-alpha signaling pathway by AdipoR2. (antibodies-online.cn)
  • Liver function in alcoholic delirium in the light of studies using J-131 labeled rose bengal The biological function of refolded and purified recombinant envelope 2 protein of Chikungunya virus was confirmed by its ability to generate envelope 2 specific antibodies with high titers in animal models. (storysteel.cf)
  • Hyperglycemia and hyperlipidemia not only cause vascular injury resulting in myocardial ischemia but also directly adversely impact ischemic cardiomyocytes, causing larger infarct size, and more severe heart failure after myocardial ischemia. (ahajournals.org)
  • Myocardial infarct area was determined by TTC staining. (bvsalud.org)
  • In depolarized myocardial infarct epicardial border zones, the cardiac sodium channel is largely inactivated, contributing to slow conduction and reentry. (biomedsearch.com)
  • The myocardial calcium content and the logarithm of the creatine kinase release during reperfusion were linearly related to the infarct size. (faintpower.gq)
  • The infarct size, neurological deficit score, TUNEL staining and the expression of proinflammatory factors or anti-inflammatory cytokines were evaluated at 72 h after reperfusion in the presence or absence of either α7nAChR antagonist (α-BGT) or agonist (PHA-543,613). (biomedcentral.com)
  • At the end of the experiment, the rats were sacrificed to measure the myocardial Infarct Size (IS) and sample the myocardial tissue to detect the content of ADP. (alliedacademies.org)
  • 1 Defining the molecular basis linking diabetes and ischemic heart disease may help in identifying novel therapeutic targets that will not only reduce myocardial infarction risk but also decrease cardiovascular mortality in diabetic patients. (ahajournals.org)
  • Remote Ischemic Postconditioning (RIP) refers to repeated short-term intermittent remote organ reperfusion and re-ischemia before the reperfusion toward one long-term myocardial ischemic period, and it can reduce myocardial ischemia/reperfusion (M-I/R) injury and enhance myocardial tolerance against relatively long-time ischemia and hypoxia [ 1 - 3 ]. (alliedacademies.org)
  • This review explores the recently described role of adiponectin as an immunomodulatory factor and how it intersects with the inflammation associated with both cardiovascular and autoimmune pathologies. (hindawi.com)
  • Since the first report of its discovery in the mid-1990s [ 1 ], adiponectin has been the focus of an increasing amount of research given its pleiotropic, beneficial effects on insulin sensitivity and systemic inflammation. (springer.com)
  • Here we review the role of inflammation and possible pyroptosis in myocardial reperfusion injury. (bvsalud.org)
  • Inhibition of inflammation enhances cardiac tolerance to ischemia and reperfusion injury. (bvsalud.org)
  • Stimulation of the purinergic P2X7 receptor and the ß-adrenergic receptor and activation of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) by toll-like receptor (TLR) agonists are all known to contribute to ischemia/reperfusion (I/R) cardiac injury through inflammation, potentially by pyroptosis. (bvsalud.org)
  • These findings indicate that the PI3K/Akt signaling pathway might play a role in DN, and alternative approaches which activate the PI3K/Akt signaling pathway and inhibit NF-κB-dependent inflammation might be a potential method of protecting against renal injury. (biomedcentral.com)
  • Basic and clinical studies have shown that hyperglycemic crises aggravate inflammation and increase the risks of myocardial infarction, heart failure, and cardiogenic shock. (springer.com)
  • High fat (HF) diet promotes progression of impaired glucose tolerance, induces insulin resistance and with chronic inflammation lead to endothelial dysfunction. (biomedcentral.com)
  • We demonstrated that neointimal formation following inflammation-associated vascular injury of the femoral artery, which was induced by polyethylene cuff placement around the artery, was significantly smaller, with decreased superoxide anion production and expression of proinflammatory cytokines compared to those in WT littermates. (pubmedcentralcanada.ca)
  • In addition to playing a critical role in antiviral immune response, cGAS has also been shown to be involved in some other important biological processes such as macular degeneration ( 8 ), cellular senescence ( 9 - 11 ), myocardial infarction-related inflammation ( 12 ), and macrophage transformation ( 13 ). (diabetesjournals.org)
  • As an integrated platform for triggering inflammation, inflammasome contributes to the pathogenesis of initiating innate immune response after cerebral ischemia/reperfusion (I/R)(Ismael et al. (biomedcentral.com)
  • In contrast to many of the other adipokines, adiponec- heart failure.8 In this study, patients with adiponectin levels tin appears to offer cardiovascular and metabolic protection in the upper two tertiles had triple the mortality risk when via insulin sensitizing, anti-inflammatory, lipid metabolism, compared with those patients within the lowest tertile. (pdfmedarticles.com)
  • Metabolically, one of the more important fat-derived factors ("adipokines") is adiponectin (APN). (aacrjournals.org)
  • Adiponectin is a primarily adipose tissue-derived cytokine that plays a key role in both metabolic and cardiac health. (mdpi.com)
  • Adiponectin (APN) is an adipocytokine secreted from adipose tissue. (ahajournals.org)
  • Adiponectin is a cytokine, "adipokine", produced almost exclusively in adipose tissue and is expressed at high levels by lean, healthy individuals. (hindawi.com)
  • Whereas adiponectin is expressed almost exclusively in adipose tissue, 11,12 plasma adiponectin levels are paradoxically decreased in obese individuals. (ahajournals.org)
  • 14 In addition, it has been shown that CRP is also produced in adipose tissues and that a significant negative relationship is found between CRP and adiponectin mRNA levels in adipose tissues. (ahajournals.org)
  • Originating in adipose tissue, generally positive metabolic effects have been attributed to adiponectin. (springer.com)
  • This type of regulation in which an unfavourable adipose tissue status triggers a more limited release of adiponectin allows it to be used as a powerful biomarker that integrates many environmental cues on the adipocyte to a circulating, easily measured plasma variable. (springer.com)
  • Adipose tissue has autocrine, paracrine, ship previously reported with type 2 diabetes mellitus-related and endocrine functions and synthesizes and releases a hypertension, HbA1c levels, insulin, BMI, and triglycerides5,7 wide array of cytokine-like products collectively termed adi- was seen despite adiponectin levels paralleling cardiovascular pokines. (pdfmedarticles.com)
  • This review focuses on intra-adipose and interorgan communication by exosomes, adiponectin-stimulated exosome production, and their dysregulation in metabolic diseases. (jci.org)
  • Adiponectin (APN) is an adipocytokine with a collagenous domain and a C-terminal globular domain and was predominantly secreted by adipose tissue [3]. (thefreelibrary.com)
  • Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress," Circulation , vol. 115, no. 11, pp. 1408-1416, 2007. (hindawi.com)
  • Negative regulation of adiponectin expression also results from hypoxia and oxidative stress [ 11 , 12 ]. (hindawi.com)
  • Molecular hydrogen is an effective antioxidant that reduces only cytotoxic reactive oxygen species (ROS) and several diseases associated with oxidative stress are sensitive to hydrogen. (beds.ac.uk)
  • The injury mechanism involves metabolic and oxidative stress, excitotoxicity, apoptosis and inflammatory processes, including activation of glial cells and infiltration of leukocytes. (biomedcentral.com)
  • 2,13 Scientists have repeatedly demonstrated that high consumption of carotenoids is protective against many oxidative stress-induced, age-related conditions. (prohealth.com)
  • Oxidative stress is an important factor related to endothelial dysfunction and ischemia-reperfusion injury, and may be implicated in the pathogenesis of heart failure, hypertension, and ischemic heart disease. (readbyqxmd.com)
  • Objective- Adiponectin (APN) system malfunction is causatively related to increased cardiovascular morbidity/mortality in diabetic patients. (ahajournals.org)
  • Reduced APN levels in type-2 diabetic patients not only contribute to increased vascular injury and MI morbidity but also play a causative role in increased cardiomyocyte death, and greater mortality in diabetic individuals post-MI. (ahajournals.org)
  • We hypothesized that decreased cardiac Adiponectin (APN) is responsible for the loss of diabetic heart sensitivity to IPO cardioprotecton. (bvsalud.org)
  • Methods Diabetic rats were subjected to I/R injury (30 min of LAD occlusion followed by 120 min of reperfusion). (bvsalud.org)
  • IPO significantly attenuated myocardial injury and up-regulated plasma APN content and cardiac p-Akt expression in non-diabetic rats but not in diabetic rats. (bvsalud.org)
  • Similarly, in the streptozotocin-induced diabetic animal model, myocardial ischemia/reperfusion-induced HIF-1α expression is impaired, indicating a critical role of hyperglycemia in HIF-1α stabilization and the impairment of angiogenesis ( 13 ). (diabetesjournals.org)
  • Studies have revealed that APN protects against myocardial IR injury, while the cardioprotective effect is attenuated in diabetic condition [4-6]. (thefreelibrary.com)
  • However, unlike APN, CTRP9 protects diabetic heart against IR injury [14], but with partially understood mechanisms. (thefreelibrary.com)
  • The aim of the present study was to investigate the role of ERS in CTRP9 induced cardioprotection against IR injury in HFD induced type 2 diabetic heart and the underlying mechanism. (thefreelibrary.com)
  • 11,12 In addition, Russell et al 9 have demonstrated that isolated hearts of AMPK-deleted mice show increased apoptosis and dysfunction after ischemia/reperfusion. (ahajournals.org)
  • Activation of AMPK by adiponectin also has been reported to protect cardiomyocytes against apoptosis and to attenuate myocardial ischemia/reperfusion injury in mice. (ahajournals.org)
  • There is a strong negative cardial cell apoptosis, and increased tumour necrosis factor a expression when compared with wild-type con- visceral fat, as well as body mass index (BMI) in both trols.9 Rescue attempts with adiponectin delivered by ade- humans and animals. (pdfmedarticles.com)
  • The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: antiinvasion activity at low concentration and apoptosis induction at high concentration. (wordpress.com)
  • Adiponectin is the most abundant plasma adipokine, and is well known for its role in energy homeostasis and insulin sensitivity [ 1 , 2 , 3 ]. (mdpi.com)
  • A number of experimental studies with genetic loss-of-function manipulations indicate that ablation of adiponectin contributes to diet-induced insulin resistance, increased vascular remodeling in response to injury, and severe cardiac damage under ischemic conditions. (ahajournals.org)
  • 21 Adiponectin activates AMPK signaling in hepatocytes, myocytes, and endothelial cells, and this increase in AMPK signaling is believed to contribute to the insulin-sensitizing and cardioprotective actions of adiponectin. (ahajournals.org)
  • In this review, we briefly discuss the key characteristics of this interesting but very complex molecule, highlight recent results in the context of its mechanism of action and summarise some of the key epidemiological data that helped establish adiponectin as a robust biomarker for insulin sensitivity, cardiovascular disease and many additional disease phenomena. (springer.com)
  • Although normal in body weight, blood glucose, and plasma insulin, heterozygotes ( Lepr db /+) also have increased metabolic efficiency and can survive a prolonged fast longer than controls. (jax.org)
  • Recently, adiponectin was found to enhance exosome biogenesis and secretion, leading to a decrease in cellular ceramides, excess of which is known to cause insulin resistance and cardiovascular disease phenotypes. (jci.org)
  • Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. (ncl.edu.tw)
  • Increased adiponectin levels improve atherosclerosis in patients with T2DM or insulin resistance. (biomedcentral.com)
  • Insulin-resistant individuals are at higher risk of developing type 2 diabetes mellitus (T2DM) and cardiovascular disease compared with subjects with normal insulin sensitivity. (ahajournals.org)
  • Effect of gestational diabetes and insulin resistance on offspring's myocardial relaxation kinetics at three years of age. (usherbrooke.ca)
  • Variants of ADIPOR2 could be a determinant for higher FFA levels, and among Chinese Han population, carriers of the CT and TT genotypes for rs2370055 even with normal glucose levels may have significantly higher insulin resistance susceptibility. (antibodies-online.cn)
  • Adiponectin is the most abundant plasma adipokine, and is well known for its role in energy homeostasis and cardiac protection. (mdpi.com)
  • 14 A series of in vitro experiments have demonstrated that adiponectin inhibits the production and action of TNFα, a key proinflammatory cytokine, in various types of cells including cardiac and vascular cells. (ahajournals.org)
  • Blockade of ß1-adrenergic receptor (AR) prevented stress-induced cardiac injury (SICI). (bvsalud.org)
  • Blockade of ß2-AR aggravated stress-induced cardiac injury. (bvsalud.org)
  • In contrast, stimulation of the cannabinoid CB2 receptor reduces I/R cardiac injury and inhibits this pathway. (bvsalud.org)
  • 1 The cardioprotective and antiapoptotic properties of Akt have been documented in cultured cardiac myocytes 2 and in myocardial ischemia/reperfusion and heart failure models. (ahajournals.org)
  • Loss of cardiomyocytes impairs cardiac function after myocardial infarction (MI). (biomedsearch.com)
  • Disturbed myocardial calcium (Ca(+)) handling is one of the pathophysiologic hallmarks of cardiovascular diseases such as congestive heart failure, cardiac hypertrophy, and certain types of tachyarrhythmias. (biomedsearch.com)
  • The role of cardiac troponins and CK-MB has been well established in the clinical algorithms to detect myocardial infarction. (intechopen.com)
  • Adiponectin translation is increased by the PPAR γ agonists pioglitazone and ω -3 fatty acids," American Journal of Physiology-Endocrinology and Metabolism , vol. 296, no. 3, pp. (hindawi.com)
  • N. Rasouli, A. Yao-Borengasser, L. M. Miles, S. C. Elbein, and P. A. Kern, "Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression," American Journal of Physiology-Endocrinology and Metabolism , vol. 290, no. 1, pp. (hindawi.com)
  • Molecular Metabolism, 14:53-59. (uzh.ch)
  • Molecular Metabolism, 8:203-210. (uzh.ch)
  • These proteins included immune proteins, blood coagulation proteins, lipid metabolism proteins, cytoskeleton proteins, energy metabolism proteins, gene regulation proteins, myocutaneous proteins, and myocardial remodeling proteins and were highly connected with each other, which indicates that the functional network of these processes contribute to the pathophysiology of AMI. (amegroups.com)
  • Age-associated characteristics of the effect of adrenomimetics on myocardial energy metabolism Protocol for its management must be developed and incorporated into daily practice. (storysteel.cf)
  • However, 5 RCTs of 3 structurally distinct inhibitors also indicate that such compounds elevate the risk of myocardial infarction and stroke. (jci.org)
  • 24. Ridker PM. Inflammatory biomarkers and risks of myocardial infarction, stroke, diabetes, and total mortality: implications for longevity. (lifeextensionvitamins.com)
  • Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor- γ -dependent mechanism in mice," Diabetes , vol. 55, no. 4, pp. 924-928, 2006. (hindawi.com)
  • The study compared mice fed with of inositol hexaphosphate (IP6) , a major component of high-fiber diets, to control mice that were not. (qualitycounts.com)
  • We investigated the potential roles and intracellular mechanisms of angiopoietin-1 (Ang-1) gene therapy on myocardial HIF-1α stabilization and vascular maturation in db/db mice. (diabetesjournals.org)
  • Aim of this study was to check the effect of high fat diet on changes in biochemical parameters as well as on process of angiogenesis in NZO mice. (biomedcentral.com)
  • NZO mice were fed with standard (ST) or high fat (HF) diet for seven weeks. (biomedcentral.com)
  • In this study the NZO mice model was implemented to investigate the correlation between main biochemical parameters and the pathological angiogenesis after feeding mice with high fat diet. (biomedcentral.com)
  • In this issue of ATVB , Devaraj et al demonstrate that physiological concentrations of adiponectin suppress CRP synthesis and secretion in human aortic endothelial cells under hyperglycemic conditions. (ahajournals.org)
  • 17,18 Adiponectin has also been shown to inhibit agonist-stimulated NF-κB signaling and suppress TNF-α secretion from a number of cell types including macrophages. (ahajournals.org)
  • We hypothesized that in response to high glucose (HG) and secretion of HepL from the endothelial cell (EC), HepL uptake and function can protect the cardiomyocyte by modifying its cell death signature. (ubc.ca)
  • In both dogs and bears, myocardial adiponectin was expressed independent of circulating adiponectin concentrations, suggesting a local regulatory mechanism within the heart. (mdpi.com)
  • Clinically, serum adiponectin concentrations are also inversely related to the risk of developing type II diabetes and cardiovascular disease, but directly related to decompensated congestive heart failure (CHF) [ 1 , 8 , 9 , 10 , 11 , 12 , 13 ]. (mdpi.com)
  • Serum adiponectin concentrations in newborn infants in early postnatal life. (diflucan2020.site)
  • To assess the linearity of the assay, samples were spiked with high concentrations of rat E-Cad in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. (cusabio.com)
  • Abstract Purpose Patients with diabetes are vulnerable to myocardial I/R (ischaemia/reperfusion) injury, but are not responsive to IPO (ischaemic post-conditioning). (bvsalud.org)
  • Serum adiponectin levels are often conflicting, with higher levels associated with poor survival in humans with congestive heart failure (CHF). (mdpi.com)
  • Sitagliptin and vildagliptin increased serum adiponectin levels and had no stronger effect than traditional oral antidiabetic drugs. (biomedcentral.com)
  • Further trials with larger sample size are needed to confirm the results and investigate the association between serum adiponectin levels and treatment of other DPP-4 inhibitors. (biomedcentral.com)
  • Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype - Atherosclerosis. (qualitycounts.com)
  • 2015 Jul 4 - 'Combination of pioglitazone and losartan is more effective in reducing renal injury-induced atherosclerosis than either treatment alone. (qualitycounts.com)
  • Previous studies have shown the associ- tion (MI)' or 'stroke' or 'atherosclerosis' or 'arteriosclerosis' ation between SNPs in ADIPOQ (rs3774261, rs1063537, or 'coronary stenosis' combined with 'ADIPOQ' or 'APM1' rs2082940, rs2241766, rs266729, and rs1501299) and or 'ACDC' or 'adiponectin gene' and 'polymorphisms' or CVD/subclinical CVD [30, 37, 38]. (deepdyve.com)
  • Moreover, patients with OSAHS without overt cardiovascular diseases show subclinical signs of atherosclerosis that are related both to the structure of the vasculature, such as increased intima-media thickness, arterial plaque formation and calcified artery atheromas 9 - 12 , and to its function, such as endothelial dysfunction and higher pulse wave velocity 13 - 16 . (ersjournals.com)
  • 7 Before the study, subjects with low pre-supplementation levels of vitamin C had 30% greater monocyte adhesion than normal, putting them at higher risk for atherosclerosis. (lifeextension.com)
  • Mitochondrial Dysfunction in Atherosclerosis Defective Mitochondrial Biogenesis: A Hallmark of the High Cardiovascular Risk in the Metabolic Syndrome? (ahajournals.org)
  • Adiponectin also exerts anti-hypertrophic effects and protects against ischemia-reperfusion injury [ 16 , 17 ]. (hindawi.com)
  • Sitosterol Protects against Myocardial Ischemia/Reperfusion Injury via Targeting PPAR? (japtr.org)
  • Devaraj et al demonstrate that adiponectin inhibits CRP production 16 in endothelial cells through its ability to modulate the AMP-kinase (AMPK) signaling pathways ( Figure ). (ahajournals.org)
  • Specifically they show that AMPK inhibition attenuates the ability of adiponectin to suppress NF-κB activity and CRP production. (ahajournals.org)
  • 6 AMPK is activated by ischemia/reperfusion, 7-9 as well as in hearts with pressure overload hypertrophy 10 and subsequent heart failure. (ahajournals.org)
  • The aim of the current study was to investigate molecular mechanisms responsible for APN transmembrane signaling and cardioprotection. (ahajournals.org)
  • 2 - 5 However, knowledge of the molecular mechanisms responsible for APN-induced cardiomyocyte protection against MI injury remains elusive. (ahajournals.org)
  • Therefore, the aims of the present study were to (1) determine the role of caveolin-3 (Cav-3) (the predominant form of caveolin expressed in cardiomyocytes) in the cardioprotective actions of APN, and (2) investigate the molecular mechanisms responsible for Cav-3 regulation of APN transmembrane signaling. (ahajournals.org)
  • High intakes of whole grain foods are inversely related to the incidence of coronary heart diseases and type 2 diabetes, but the mechanisms remain unclear. (diva-portal.org)
  • Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms. (biomedcentral.com)
  • The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. (doabooks.org)
  • So far, the intracellular molecular mechanisms by which hyperglycemia decreases HIF-1α expression have not been identified. (diabetesjournals.org)
  • In a previous study, we demonstrated that Ang-1 is an important component in regulating coronary artery endothelial NO production and that Ang-1 mediates myocardial angiogenesis in endothelial NO synthase (eNOS)/NO-dependent mechanisms ( 18 ). (diabetesjournals.org)
  • Molecular mechanisms of peritoneal permeability--research in growth factors. (faintpower.gq)
  • Adiponectin accumulates in tissues such as heart, muscle, and vascular endothelium through binding with T-cadherin, a glycosylphosphatidylinositol-anchored (GPI-anchored) cadherin. (jci.org)
  • Myocardial HIF-1α, vascular endothelial growth factor (VEGF), hemeoxygenase-1 (HO-1), endothelial nitric oxide synthase (eNOS), Akt, and HIF-1α-prolyl-4-hydroxylase-2 (PHD)2 expression were measured. (diabetesjournals.org)
  • Taken together, our data show that Ang-1 increases myocardial vascular maturation and angiogenesis together with suppression of PHD2 and the upregulation of HIF-1α signaling. (diabetesjournals.org)
  • Even after a vascular "event" such as a heart attack or stroke, astaxanthin helps mitigate the damage by reducing the burst of oxygen free radicals generated in the destructive "ischemia-reperfusion" injury. (prohealth.com)
  • High altitude and cancer mortality. (uzh.ch)
  • A higher rate of hospitalizations determines higher mortality. (biomedsearch.com)
  • An understanding of the internal link between type 2 diabetes and cardiovascular injury may help identifying novel therapies alleviating ischemic myocardial injury to reduce cardiovascular morbidity and mortality. (thefreelibrary.com)
  • Changes in ischemic tolerance and cardioprotective signaling may contribute to substantially higher mortality and morbidity following ischemic insult in DM patients. (paperity.org)
  • In contrast to humans, serum adiponectin was significantly lower in dogs with CHF and lowest levels in the severest CHF class. (mdpi.com)
  • The expression of HIF-1α and VEGF is significantly increased in the human heart during ischemia, which may contribute to the limitation of ischemic injury by promoting angiogenesis and collateral vessel formation ( 11 ). (diabetesjournals.org)
  • Compared with placebo, DPP4i (sitagliptin and vildagliptin) treatment significantly elevated adiponectin levels by 0.74 μg/mL (95% confidence interval [CI], 0.45 to 1.03) relative to that using an active-comparison by 0.00 μg/mL (95% CI, −0.57 to 0.56). (biomedcentral.com)
  • Moreover, serum adiponectin concentration in ATIP1 chimera was significantly higher than that in WT chimera (WT as BM donor) and KKAy chimera (KKAy as BM donor). (pubmedcentralcanada.ca)
  • Abstract Background and objectives: Dexmedetomidine has demonstrated protective effects against lung injury in vitro. (bvsalud.org)
  • Adiponectin inhibits the expression of TNF- α in adipocytes, and both TNF- α and IL-6 inhibit the production of adiponectin [ 9 , 10 ]. (hindawi.com)
  • In this focused review, we highlight areas of potential molecular interplay between adipocytes and cardiomyocytes. (frontiersin.org)
  • Direct effect refers to adipocyte or fatty infiltration of the atrial and ventricular myocardium itself, possibly causing increased dispersion of normal myocardial electrical signals and fibrotic substrate of adipocytes that promote reentry or adipocytes serving as a direct source of aberrant signals. (frontiersin.org)
  • Lipids in Health and Disease (2018) 17:126 Page 2 of 21 kidney disease [33, 34], and even gynecological condi- 'ischemic heart disease' or 'angina' or 'myocardial infarc- tions [35, 36]. (deepdyve.com)
  • Patients with type 2 diabetes have increased risk of developing ischemic heart disease and more severe and fatal myocardial infarctions than nondiabetic population [1, 2]. (thefreelibrary.com)
  • Science Daily, 9/21/15 - 'in an animal model, brain injury produces an inflammatory response in the blood and body's organs, especially the liver. (qualitycounts.com)
  • In obese subjects, adiponectin levels are decreased, and the ability of adiponectin to inhibit the inflammatory processes is limited. (hindawi.com)
  • The contents of inflammasome proteins were gradually increased after cerebral ischemia/reperfusion (I/R). EA stimulus attenuated NLRP3 inflammasome mediated inflammatory reaction and regulated the balance between proinflammatory factors and anti-inflammatory cytokines. (biomedcentral.com)
  • A, The longitudinal normal myocardial mitochondrial morphology in the Sprague-Dawley control male rat model at 10 weeks of age. (ahajournals.org)
  • In addition to promoting adipocyte differentiation, PPAR- γ agonists are known to increase adiponectin expression both in vitro and in vivo [ 9 ]. (hindawi.com)
  • Sensitive quantification of the somatostatin analog AP102 in plasma by ultra-high pressure liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study in rats. (uzh.ch)
  • Coronary artery occlusion (45 min) and reperfusion (2 h) was performed in rats anesthetized with α-chloralose. (bvsalud.org)
  • Here, we investigated whether dexmedetomidine preconditioning protected against lung injury in hemorrhagic shock rats. (bvsalud.org)
  • Conclusion: Dexmedetomidine preconditioning has a protective effect against lung injury caused by hemorrhagic shock in rats. (bvsalud.org)
  • In adult male Sprague-Dawley rats, the focal cerebral ischemic injury was induced by middle cerebral artery occlusion (MCAO) models for 1.5 h. (biomedcentral.com)
  • 2013 ). In addition, we demonstrated that EA could attenuate cerebral ischemic injury via regulation of α7nAChR-mediated inhibition of HMGB1 release in rats (Wang et al. (biomedcentral.com)
  • A total of 57 healthy male SD rats were randomly divided into 3 groups (the sham operation group (S), the myocardial ischemia-reperfusion group (I/R), and the RIP group (R). The myocardial ischemia-reperfusion injury model was established by ligating the left coronary artery for 30 min followed by 180-min reperfusion. (alliedacademies.org)
  • In this study, we established the rat RIP model and the M-I/R model, aiming to observe the myocardial protective roles of RIP and the serum and myocardial ADP changes in rats. (alliedacademies.org)
  • A large-scale clinical trial (the UK Prospective Diabetes Study [UKPDS] 34) has shown that metformin therapy decreased the risk of cardiovascular death and the incidence of myocardial infarction associated with diabetes mellitus, 1 suggesting that this drug may be useful for patients who have both cardiovascular disease and diabetes mellitus. (ahajournals.org)
  • Myocardial Infarction (MI) is the most common cardiovascular disease. (frontiersin.org)
  • 8 The findings indicated that through supplementation with vitamin C, scientists were able to regulate how specific genes produce vital proteins, thereby reducing the risk of cardiovascular disease at the molecular level. (lifeextension.com)
  • Szeker K, Niemitalo O, Casteleijn MG, Juffer AH, Neubauer P. High-temperature cultivation and 5' mRNA optimization are key factors for the efficient overexpression of thermostable Deinococcus geothermalis purine nucleoside phosphorylase in Escherichia coli. (oulu.fi)
  • Molecular and cellular experiments revealed that APN receptor 1 (AdipoR1) colocalized with Cav-3, forming AdipoR1/Cav-3 complex via specific Cav-3 scaffolding domain binding motifs. (ahajournals.org)
  • 5 CSIR-Center for Cellular and Molecular Biology, Hyderabad, India. (sciencemag.org)
  • Molecular and Cellular Biology 24 (12): 5404-5420. (mdc-berlin.de)
  • However, it has been reported that in pathological conditions such as coronary artery disease (CAD), diabetes mellitus, and hypertension that adiponectin levels decline [ 1 - 4 ]. (hindawi.com)
  • Conclusion Protective effect of IPO was tightly correlated with the expression of adiponectin, exacerbation of I/R injury and ineffectiveness of IPO was partially due to the decline of adiponectin and inactivation of Akt in diabetes mellitus. (bvsalud.org)
  • 16 Devaraj et al demonstrated that adiponectin inhibits high glucose-induced CRP production through its ability to suppress nuclear factor-κ B (NF-κB) activation. (ahajournals.org)
  • Although it binds adiponectin, it is not a signalling receptor per se, as it lacks an intracellular signalling domain. (springer.com)
  • Opioid receptor agonists were administered intravenously 5 min before reperfusion, while opioid receptor antagonists were administered 10 min before reperfusion. (bvsalud.org)
  • Our previous research confirmed that electroacupuncture (EA) stimulus elicits neuroprotective effects against cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR)-mediated inhibition of high-mobility group box 1 release mechanism. (biomedcentral.com)
  • 2009 ) and regulate the Reperfusion Injury Salvage Kinase (RISK) signaling pathway (ERKε, PKC, GSK-3β, STAT3) via cannabinoid receptor 1 (CB1R)(Wang et al. (biomedcentral.com)
  • 13 This regulation of adiponectin results, at least in part, from the upregulation of tumor necrosis factor (TNF)-α and other proinflammatory cytokines which inhibits the synthesis of adiponectin in the obese state. (ahajournals.org)
  • Routine virologic study revealed a high antimeasles virus antibody titer (1:1280 by hemagglutination-inhibition) which progressively decreased. (faintpower.gq)
  • Vitamin C is rapidly finding new applications in protecting against endothelial dysfunction, high blood pressure, and the blood vessel changes that precede heart disease. (lifeextension.com)
  • Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway. (mdc-berlin.de)
  • Lifestyle interventions such as exercise, weight reduction, low consumption of purine-rich meat, or avoiding high fructose intake are recommended for all hyperuricemic patients. (readbyqxmd.com)
  • A molecular pathogenesis for transcription factor associated poly-alanine tract expansions. (mdc-berlin.de)
  • This study evaluated the usefulness of speckle tracking imaging (STI) in assessment of myocardial contractility in intra-abdominal hypertension experimentally induced in mini-pigs. (biomedsearch.com)
  • Adiponectin is encoded by ADIPOQ which is located in chromosome 3q27 [21], and adiponectin levels are influenced by single-nucleotide polymorphisms (SNPs) * Correspondence: [email protected] † in ADIPOQ [22]. (deepdyve.com)
  • Variations could be seen in all evidence based therapies including antiplatelet therapy, beta-blockers, ACE-inhibitors, statins, reperfusion therapy, and use of coronary angiography. (slideshare.net)
  • Brain vessel occlusion by thrombus or embolus is a primary event triggering tissue injury. (biomedsearch.com)
  • In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. (doabooks.org)
  • The expression of NLRP3 inflammasome in the penumbral tissue following reperfusion was assessed by western blotting and immunoflourescent staining. (biomedcentral.com)
  • Astaxanthin promotes the strength of the heart muscle's "squeeze," which may help the heart to maintain normal blood flows both before and after an injury to the tissue. (prohealth.com)
  • However, consistent with these unusual properties, adiponectin release from the adipocyte is generally downregulated under metabolically unfavourable conditions, resulting in reduced circulating levels in the plasma. (springer.com)
  • Plasma adiponectin - an independent indicator of liver fat accumulation. (oulu.fi)
  • In this study, immunodepletion of high-abundance plasma proteins followed by an isobaric tagging for relative and absolute quantitation (iTRAQ)-based quantitative proteomic approach was used to analyze plasma samples from 5 control individuals and 10 AMI patients. (amegroups.com)
  • CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations. (mdc-berlin.de)