Hexuronic Acids
Iduronic Acid
Uronic Acids
Glucuronates
Glucuronic Acid
Heparitin Sulfate
Glycosaminoglycans
Chondroitin Sulfates
Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.
Carbohydrate Sequence
Oligosaccharides
Ascorbic Acid
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
Nutrition Policy
Encyclopedias as Topic
Recommended Dietary Allowances
Nutritional Requirements
Ascorbic Acid Deficiency
A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
Food, Fortified
Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the food normally. Fortified food includes also food to which various nutrients have been added to compensate for those removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)
Parapsychology
Sexology
Psychoanalysis
The separation or resolution of the psyche into its constituent elements. The term has two separate meanings: 1. a procedure devised by Sigmund Freud, for investigating mental processes by means of free association, dream interpretation and interpretation of resistance and transference manifestations; and 2. a theory of psychology developed by Freud from his clinical experience with hysterical patients. (From Campbell, Psychiatric Dictionary, 1996).
Occultism
Chemistry, Physical
Antioxidants
Tannins
Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.
Klebsiella pneumoniae
Strongyloides stercoralis
MedlinePlus
Consumer Health Information
Social Media
Dissent and Disputes
Scurvy
An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs.
Adrenal Glands
L-Gulonolactone Oxidase
Arteriosclerosis
Lipoproteins
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
Atherosclerosis
Lipoproteins, LDL
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
Cholesterol
Study of the response of a biofilm bacterial community to UV radiation. (1/801)
We have developed a bioluminescent whole-cell biosensor that can be incorporated into biofilm ecosystems. RM4440 is a Pseudomonas aeruginosa FRD1 derivative that carries a plasmid-based recA-luxCDABE fusion. We immobilized RM4440 in an alginate matrix to simulate a biofilm, and we studied its response to UV radiation damage. The biofilm showed a protective property by physical shielding against UV C, UV B, and UV A. Absorption of UV light by the alginate matrix translated into a higher survival rate than observed with planktonic cells at similar input fluences. UV A was shown to be effectively blocked by the biofilm matrix and to have no detectable effects on cells contained in the biofilm. However, in the presence of photosensitizers (i.e., psoralen), UV A was effective in inducing light production and cell death. RM4440 has proved to be a useful tool to study microbial communities in a noninvasive manner. (+info)The A modules of the Azotobacter vinelandii mannuronan-C-5-epimerase AlgE1 are sufficient for both epimerization and binding of Ca2+. (2/801)
The industrially important polysaccharide alginate is composed of the two sugar monomers beta-D-mannuronic acid (M) and its epimer alpha-L-guluronic acid (G). In the bacterium Azotobacter vinelandii, the G residues originate from a polymer-level reaction catalyzed by one periplasmic and at least five secreted mannuronan C-5-epimerases. The secreted enzymes are composed of repeats of two protein modules designated A (385 amino acids) and R (153 amino acids). The modular structure of one of the epimerases, AlgE1, is A1R1R2R3A2R4. This enzyme has two catalytic sites for epimerization, each site introducing a different G distribution pattern, and in this article we report the DNA-level construction of a variety of truncated forms of the enzyme. Analyses of the properties of the corresponding proteins showed that an A module alone is sufficient for epimerization and that A1 catalyzed the formation of contiguous stretches of G residues in the polymer, while A2 introduces single G residues. These differences are predicted to strongly affect the physical and immunological properties of the reaction product. The epimerization reaction is Ca2+ dependent, and direct binding studies showed that both the A and R modules bind this cation. The R modules appeared to reduce the Ca2+ concentration needed for full activity and also stimulated the reaction rate when positioned both N and C terminally. (+info)Modes of action of five different endopectate lyases from Erwinia chrysanthemi 3937. (3/801)
Five endopectate lyases from the phytopathogenic bacterium Erwinia chrysanthemi, PelA, PelB, PelD, PelI, and PelL, were analyzed with respect to their modes of action on polymeric and oligomeric substrates (degree of polymerization, 2 to 8). On polygalacturonate, PelB showed higher reaction rates than PelD, PelI, and PelA, whereas the reaction rates for PelL were extremely low. The product progression during polygalacturonate cleavage showed a typical depolymerization profile for each enzyme and demonstrated their endolytic character. PelA, PelI, and PelL released oligogalacturonates of different sizes, whereas PelD and PelB released mostly unsaturated dimer and unsaturated trimer, respectively. Upon prolonged incubation, all enzymes degraded the primary products further, to unsaturated dimer and trimer, except for PelL, which degraded the primary products to unsaturated tetramer and pentamer in addition to unsaturated dimer and trimer. The bond cleavage frequencies on oligogalacturonates revealed differences in the modes of action of these enzymes that were commensurate with the product progression profiles. The preferential products formed from the oligogalacturonates were unsaturated dimer for PelD, unsaturated trimer for PelB, and unsaturated tetramer for PelI and PelL. For PelA, preferential products were dependent on the sizes of the oligogalacturonates. Whereas PelB and PelD displayed their highest activities on hexagalacturonate and tetragalacturonate, respectively, PelA, PelI, and PelL were most active on the octamer, the largest substrate used. The bond cleavage frequencies and reaction rates were used to estimate the number of subsites of each enzyme. (+info)Biodegradable alginate microspheres as a delivery system for naked DNA. (4/801)
Sodium alginate is a naturally occurring polysaccharide that can easily be polymerized into a solid matrix to form microspheres. These biodegradable microspheres were used to encapsulate plasmid DNA containing the bacterial beta-galactosidase (LacZ) gene under the control of either the cytomegalovirus (CMV) immediate-early promoter or the Rous sarcoma virus (RSV) early promoter. Mice inoculated orally with microspheres containing plasmid DNA expressed LacZ in the intestine, spleen and liver. Inoculation of mice with microspheres containing both the plasmid DNA and bovine adenovirus type 3 (BAd3) resulted in a significant increase in LacZ expression compared to those inoculated with microspheres containing only the plasmid DNA. Our results suggest that adenoviruses are capable of augumenting transgene expression by plasmid DNA both in vitro and in vivo. (+info)Salt-resistant alpha-helical cationic antimicrobial peptides. (5/801)
Analogues based on the insect cecropin-bee melittin hybrid peptide (CEME) were studied and analyzed for activity and salt resistance. The new variants were designed to have an increase in amphipathic alpha-helical content (CP29 and CP26) and in overall positive charge (CP26). The alpha-helicity of these peptides was demonstrated by circular dichroism spectroscopy in the presence of liposomes. CP29 was shown to have activity against gram-negative bacteria that was similar to or better than those of the parent peptides, and CP26 had similar activity. CP29 had cytoplasmic membrane permeabilization activity, as assessed by the unmasking of cytoplasmic beta-galactosidase, similar to that of CEME and its more positively charged derivative named CEMA, whereas CP26 was substantially less effective. The activity of the peptides was not greatly attenuated by an uncoupler of membrane potential, carbonyl cyanide-m-chlorophenylhydrazone. The tryptophan residue in position 2 was shown to be necessary for interaction with cell membranes, as demonstrated by a complete lack of activity in the peptide CP208. Peptides CP29, CEME, and CEMA were resistant to antagonism by 0.1 to 0.3 M NaCl; however, CP26 was resistant to antagonism only by up to 160 mM NaCl. The peptides were generally more antagonized by 3 and 5 mM Mg2+ and by the polyanion alginate. It appeared that the positively charged C terminus in CP26 altered its ability to permeabilize the cytoplasmic membrane of Escherichia coli, although CP26 maintained its ability to kill gram-negative bacteria. These peptides are potential candidates for future therapeutic drugs. (+info)Atomic levers control pyranose ring conformations. (6/801)
Atomic force microscope manipulations of single polysaccharide molecules have recently expanded conformational chemistry to include force-driven transitions between the chair and boat conformers of the pyranose ring structure. We now expand these observations to include chair inversion, a common phenomenon in the conformational chemistry of six-membered ring molecules. We demonstrate that by stretching single pectin molecules (1 --> 4-linked alpha-D-galactouronic acid polymer), we could change the pyranose ring conformation from a chair to a boat and then to an inverted chair in a clearly resolved two-step conversion: 4C1 right arrow over left arrow boat right arrow over left arrow 1C4. The two-step extension of the distance between the glycosidic oxygen atoms O1 and O4 determined by atomic force microscope manipulations is corroborated by ab initio calculations of the increase in length of the residue vector O1O4 on chair inversion. We postulate that this conformational change results from the torque generated by the glycosidic bonds when a force is applied to the pectin molecule. Hence, the glycosidic bonds act as mechanical levers, driving the conformational transitions of the pyranose ring. When the glycosidic bonds are equatorial (e), the torque is zero, causing no conformational change. However, when the glycosidic bond is axial (a), torque is generated, causing a rotation around C---C bonds and a conformational change. This hypothesis readily predicts the number of transitions observed in pyranose monomers with 1a-4a linkages (two), 1a-4e (one), and 1e-4e (none). Our results demonstrate single-molecule mechanochemistry with the capability of resolving complex conformational transitions. (+info)Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung. (7/801)
The leading cause of mortality in patients with cystic fibrosis (CF) is respiratory failure due in large part to chronic lung infection with Pseudomonas aeruginosa strains that undergo mucoid conversion, display a biofilm mode of growth in vivo and resist the infiltration of polymorphonuclear leukocytes (PMNs), which release free oxygen radicals such as H2O2. The mucoid phenotype among the strains infecting CF patients indicates overproduction of a linear polysaccharide called alginate. To mimic the inflammatory environment of the CF lung, P. aeruginosa PAO1, a typical non-mucoid strain, was grown in a biofilm. This was treated with low levels of H2O2, as if released by the PMNs, and the formation of mucoid variants was observed. These mucoid variants had mutations in mucA, which encodes an anti-sigma factor; this leads to the deregulation of an alternative sigma factor (sigma22, AlgT or AlgU) required for expression of the alginate biosynthetic operon. All of the mucoid variants tested showed the same mutation, the mucA22 allele, a common allele seen in CF isolates. The mucoid mucA22 variants, when compared to the smooth parent strain PA01, (i) produced 2-6-fold higher levels of alginate, (ii) exhibited no detectable differences in growth rate, (iii) showed an unaltered LPS profile, (iv) were approximately 72% reduced in the amount of inducible-beta-lactamase and (v) secreted little or no LasA protease and only showed 44% elastase activity. A characteristic approximately 54 kDa protein associated with alginate overproducing strains was identified as AlgE (Alg76) by N-terminal sequence analysis. Thus, the common phenotype of the mucoid variants, which included a genetically engineered mucA22 mutant, suggested that the only mutation incurred as a result of H2O2 treatment was in mucA. When a P. aeruginosa biofilm was repeatedly exposed to activated PMNs in vitro, mucoid variants were also observed, mimicking in vivo observations. Thus, PMNs and their oxygen by-products may cause P. aeruginosa to undergo the typical adaptation to the intractable mu- coid form in the CF lung. These findings indicate that gene activation in bacteria by toxic oxygen radicals, similar to that found in plants and mammalian cells, may serve as a defence mechanism for the bacteria. This suggests that mucoid conversion is a response to oxygen radical exposure and that this response is a mechanism of defence by the bacteria. This is the first report to show that PMNs and their oxygen radicals can cause this phenotypic and genotypic change which is so typical of the intractable form of P. aeruginosa in the CF lung. These findings may provide a basis for the development of anti-oxidant and anti-inflammatory therapy for the early stages of infection in CF patients. (+info)Transfer and subsequent metabolism of lysolipids studied by immobilizing subcellular compartments in alginate beads. (8/801)
The transfer and subsequent metabolism of lysophosphatidylcholine between subcellular compartments were studied in vitro by embedding membranes in alginate beads. After several experiments to validate the process, it was demonstrated that lysophosphatidylcholine was transferred from microsomes embedded in alginate beads to immobilized chloroplasts, that this transfer involved the partition of this molecule, and that the imported lysophosphatidylcholine was further used as substrate for phosphatidylcholine biosynthesis. More generally, the technique used makes it possible to avoid any cross-contamination between compartments, to evidence a transfer of molecules, and to study the metabolism of the imported molecules in the acceptor compartment. (+info)
Effects of mannuronic acid (M2000) on gene expression profile of signal transducer and activator of transcription proteins ...
Hexuronate transporter elisa and antibody
3D porous chitosan-alginate scaffolds: A new matrix for studying prostate cancer cell-lymphocyte interactions in vitro<...
Probable exopolygalacturonase elisa and antibody
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Property of Alginate - IRO Alginate Industry Co., Ltd.
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Albert Szent-Györgyi
His research involved isolating an organic acid, which he then called "hexuronic acid", from adrenal gland tissue. He accepted ... There Szent-Györgyi and his research fellow Joseph Svirbely found that "hexuronic acid" was actually the thus far unidentified ... He is credited with first isolating vitamin C and discovering the components and reactions of the citric acid cycle. He was ... identifying fumaric acid and other steps in what would become known as the Krebs cycle. In Szeged he also met Zoltán Bay, ...
Amygdalin
US 2985664, Krebs, Ernst T. & Ernst T. Krebs, Jr., "Hexuronic acid derivatives" Carpenter D (2010). Reputation and Power: ... and prussic acid; while hydrochloric acid gives mandelic acid, D-glucose, and ammonia. In 1845 amygdalin was used as a cancer ... Ernst T. Krebs (not to be confused with Hans Adolf Krebs, the discoverer of the citric acid cycle) branded laetrile as a ... J. W. Walker; V. K. Krieble (1909). "The hydrolysis of amygdalin by acids. Part I". Journal of the Chemical Society. 95 (11): ...
Scurvy
... "hexuronic acid".[65] Szent-Györgyi suspected hexuronic acid, which he had isolated from adrenal glands, to be the antiscorbutic ... Because of this, hexuronic acid was subsequently renamed ascorbic acid. 21st century[edit]. Rates of scurvy in most of the ... In 1932, the connection between hexuronic acid and scurvy was finally proven by American researcher Charles Glen King of the ... King's laboratory was given some hexuronic acid by Szent-Györgyi and soon established that it was the sought-after anti- ...
Kwas askorbinowy, wolna encyklopedia
Wykazał, że wyodrębniony związek ma właściwości przeciwszkorbutowe i nadał mu nazwę „kwas heksauronowy" (hexuronic acid). W ... Oxalic acid excretion after intravenous ascorbic acid administration. „Metabolism". 58 (2), s. 263-269, 2009. DOI: 10.1016/j. ... Effect of large intake of ascorbic acid on urinary and plasma oxalic acid levels. „International Journal of Vitamin and ... a b Nutrients: Vitamin C, total ascorbic acid(mg). Food Groups: Finfish and Shellfish Products (ang.). W: USDA Food Composition ...
Charles Glen King
... focusing on hexuronic acid. The chemical identity of King's active substance was almost identical to Szent-Györgyi's hexuronic ... acid, but the research of S.S. Silva had declared the hexuronic acid was not vitamin C. However, within two weeks of each other ... published articles declaring that vitamin C and hexuronic acid were indeed the same compound. Szent-Györgyi would later win a ...
Polysulfated glycosaminoglycan
It is made of repeat disaccharide units (comprising hexosamine and hexuronic acid), and is similar to glycosaminoglycans ... PSGAG inhibits many of the catabolic enzymes that degrade cartilage, proteoglycans, and hyaluronic acid. The enzymes that are ... PSGAG also stimulates the synthesis of glycosaminoglycans, hyaluronic acid, and collagen, which increase synovial viscosity. It ... where hyaluronic acid is the stem and the side chains are the bristles. When pressure is exerted on the joint, fluids move ...
L-gulonolactone oxidase
The L-xylo-hex-3-gulonolactone (2-keto-gulono-gamma-lactone) is able to convert to hexuronic acid (ascorbic acid) spontaneously ... Ascorbic acid/Vitamin C Oxidoreductase Scurvy GULOP Archived 2007-09-27 at the Wayback Machine - iHOP Nishikimi M, Koshizaka T ... However, the tissues of animal models with a GULO gene generally have high levels of ascorbic acid and so are often only ... There exists a wide discrepancy between the amounts of ascorbic acid other primates consume and what is recommended as " ...
Glycosaminoglycan
... hexose or hexuronic acid unit they contain (e.g. glucuronic acid, iduronic acid, galactose, galactosamine, glucosamine). ... Distinguished from chondroitin sulfate by the presence of iduronic acid, although some hexuronic acid monosaccharides may be ... Hexuronic acid / Hexose. Hexosamine. Linkage geometry between predominant monomeric units. Unique features ... Hyaluronic acid[edit]. The fourth class of GAG, hyaluronan (or hyaluronic acid), is not sulfated and is synthesized by three ...
Albert Szent-Györgyi
... "hexuronic acid", from adrenal gland tissue.. He accepted a position at the University of Szeged in 1930.[7] There, Szent- ... "hexuronic acid" was actually the thus far unidentified antiscorbutic factor, known as vitamin C. After Walter Norman Haworth ... He received his PhD from Fitzwilliam College, Cambridge in 1927 for work on isolating an organic acid, which he then called " ... vitamin C, discovering the components and reactions of the citric acid cycle. ...
Heparan sulfate 2-O-sulfotransferase
... catalysing the transfer of sulfate to the C2-position of selected hexuronic acid residues within the nascent HS chain. Mice ...
Glucuronolactone
... which may be oxidized to glucaric acid, or isomerized to another hexuronic acid, so there is no reasonable toxicity mechanism. ... "Effect of D-glucuronic acid and D-glucuronolactone on ascorbic acid levels in blood and urine of man and dog". Am J Clin Nutr. ... and humans may also be able to use glucuronolactone as a precursor for ascorbic acid synthesis. Glucuronic acid Glucono delta- ... Free glucuronic acid (or its self-ester glucuronolactone) has less effect on detoxification than glucose,[citation needed] ...
Vitamin deficiency
In 1931, Albert Szent-Györgyi and a fellow researcher Joseph Svirbely suspected that "hexuronic acid" was actually vitamin C, ... "Pantothenic Acid". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid ... Niacin deficiency is a consequence of a diet low in both niacin and the amino acid tryptophan, a precursor for the vitamin. ... Pantothenic acid (Vitamine B5) deficiency is extremely rare. Symptoms include irritability, fatigue, and apathy. Vitamin B6 ...
Vitamin C
Haworth and Szent-Györgyi proposed that L-hexuronic acid be named a-scorbic acid, and chemically L-ascorbic acid, in honor of ... Ascorbic acid is a weak sugar acid structurally related to glucose. In biological systems, ascorbic acid can be found only at ... The biosynthesis of ascorbic acid in vertebrates starts with the formation of UDP-glucuronic acid. UDP-glucuronic acid is ... E304 fatty acid esters of ascorbic acid such as ascorbyl palmitate (approved for use as a food additive in the EU,[88] U.S.[89] ...
List of MeSH codes (D09)
... hexuronic acids MeSH D09.811.922.400.500 - iduronic acid MeSH D09.853.329.225 - erythrityl tetranitrate MeSH D09.853.400.350 - ... n-acetylneuraminic acid MeSH D09.811.922.325 - glucuronic acids MeSH D09.811.922.325.300 - glucuronic acid MeSH D09.811.922.325 ... sialic acids MeSH D09.067.687.668.250 - cytidine monophosphate n-acetylneuraminic acid MeSH D09.067.687.668.550 - n- ... sialic acids MeSH D09.811.589.668.250 - cytidine monophosphate n-acetylneuraminic acid MeSH D09.811.589.668.550 - ...
Vitamin
In 1931, Albert Szent-Györgyi and a fellow researcher Joseph Svirbely suspected that "hexuronic acid" was actually vitamin C, ... folic acid or folate), vitamin B12 (cobalamins), vitamin C (ascorbic acid), vitamin D (calciferols), vitamin E (tocopherols and ... For example, B9 is folic acid and five of the folates are in the range B11 through B16. Others, such as PABA (formerly B10), ... Recommendations for folic acid supplementation during pregnancy reduced risk of infant neural tube defects. The term vitamin is ...
Norman Haworth
Haworth had been given his initial reference sample of "water-soluble vitamin C" or "hexuronic acid" (the previous name for the ... In honour of the compound's antiscorbutic properties, Haworth and Szent-Györgyi now proposed the new name of "a-scorbic acid" ... for the molecule, with L-ascorbic acid as its formal chemical name. During World War II, he was a member of the MAUD Committee ... was a British chemist best known for his groundbreaking work on ascorbic acid (vitamin C) while working at the University of ...
Glucuronic acid
... is a precursor of ascorbic acid (vitamin C, formerly called as L-hexuronic acid). Ascorbate can be ... Gluconic acid Isosaccharinic acid Uronic acid D-Glucuronic acid at Sigma-Aldrich Ohno, Shuji; Nakajin, Shizuo (2008-10-06). " ... Glucuronic acid is a sugar acid derived from glucose, with its sixth carbon atom oxidized to a carboxylic acid. In living ... Glucuronic acid (from Greek γλυκύς "sweet" and οὖρον "urine") is a uronic acid that was first isolated from urine (hence the ...
Uronic acid
Gluconic acid Glucuronic acid Isosaccharinic acid "Hexuronic acid". encyclopedia.com. Uronic+Acids at the US National Library ... the uronic acid analog of glucose is glucuronic acid. Uronic acids derived from hexoses are known as hexuronic acids and uronic ... Uronic acids (/ʊˈrɒnɪk/) are a class of sugar acids with both carbonyl and carboxylic acid functional groups. They are sugars ... while oxidation of both the terminal hydroxyl group and the aldehyde yields an aldaric acid. The names of uronic acids are ...
Hexuronic acid
... is any uronic acid derived from a hexose. These include fructuronic acids, galacturonic acids, glucuronic acids ... mannuronic acids, and tagaturonic acids. In the early 1900s, ascorbic acid (vitamin C) was also known as hexuronic acid. This ... "hexuronic acid (CHEBI:24592)". www.ebi.ac.uk. Retrieved 31 March 2018. HERBERT, R. W.; HIRST, E. L. (6 August 1932). "The ... Absorption Spectrum of Hexuronic Acid". Nature. 130 (3275): 205. doi:10.1038/130205a0. ISSN 1476-4687. This set index page ...
D-Galacturonic acid
It is also a uronic acid or hexuronic acid. Naturally occurring uronic acids are d-glucuronic acid, d-galacturonic acid, l- ... Other oxidized forms of d-galactose are d-galactonic acid (carboxylic group at C1) and meso-galactaric acid (mucic acid) ( ... d-Galacturonic acid is a sugar acid, an oxidized form of d-galactose. It is the main component of pectin, in which it exists as ... iduronic acid and d-mannuronic acid. Debra Mohnen "Pectin structure and biosynthesis" Current Opinion in Plant Biology 2008, 11 ...
Chemistry of ascorbic acid
Ascorbic acid is an organic compound with formula C 6H 8O 6, originally called hexuronic acid. It is a white solid, but impure ... Colour retention agent Erythorbic acid: a diastereomer of ascorbic acid. Mineral ascorbates: salts of ascorbic acid Acids in ... xylonic acid, threonic acid and oxalic acid. Reactive oxygen species are damaging to animals and plants at the molecular level ... Between 1928 and 1932, Albert Szent-Györgyi isolated a candidate for this substance, which he called it "hexuronic acid", first ...
ಆಲ್ಬರ್ಟ್ ಝೆಂಟ್-ಗಿಯೋಗ್ರ್ಯಿ - ವಿಕಿಪೀಡಿಯ
... hexuronic acid) ಎಂಬುದಾಗಿ ನಾಮಕರಣ ಮಾಡಿದರು. ಸ್ವಾರಸ್ಯವೆಂದರೆ ಝೆಂಟ್-ಗಿಯೋಗ್ರ್ಯಿಯವರು ಸಿ-ಜೀವಸತ್ವವನ್ನು ಹೊಂದಿರುದ ಕೋಸುಗಳು ಮತ್ತು ... ಕೊನೆಗೆ ಆ ಆಮ್ಲಕ್ಕೆ ಕಅಸ್ಕಾರ್ಬಿಕ್ ಆಮ್ಲಕಿ (ascorbic acid) ಎಂದು ಕರೆಯಲಾಯಿತು.ಝೆಂಟ್-ಗಿಯೋಗ್ರ್ಯಿಯವರ ಈ ಸಂಶೋಧನೆ ಮುಂದೆ ಇತರ ವಿಜ್ಞಾನಿಗಳಾದ ...
Vitamin C
Haworth and Szent-Györgyi proposed that L-hexuronic acid be named a-scorbic acid, and chemically l-ascorbic acid, in honor of ... Ascorbic acid is a weak sugar acid structurally related to glucose. In biological systems, ascorbic acid can be found only at ... to produce ascorbic acid. l-Ascorbic acid has a negative feedback on l-galactose dehydrogenase in spinach. Ascorbic acid efflux ... The biosynthesis of ascorbic acid in vertebrates starts with the formation of UDP-glucuronic acid. UDP-glucuronic acid is ...
Vitamin C
Haworth and Szent-Györgyi proposed that L-hexuronic acid be named a-scorbic acid, and chemically l-ascorbic acid, in honor of ... Ascorbic acid is a weak sugar acid structurally related to glucose. In biological systems, ascorbic acid can be found only at ... The biosynthesis of ascorbic acid in vertebrates starts with the formation of UDP-glucuronic acid. UDP-glucuronic acid is ... Vitamin C, also known as ascorbic acid and l-ascorbic acid, is a vitamin found in various foods and sold as a dietary ...
Hexuronic acid - Wikipedia
Hexuronic acid is any uronic acid derived from a hexose. These include fructuronic acids, galacturonic acids, glucuronic acids ... mannuronic acids, and tagaturonic acids. In the early 1900s, ascorbic acid (vitamin C) was also known as hexuronic acid. This ... "hexuronic acid (CHEBI:24592)". www.ebi.ac.uk. Retrieved 31 March 2018. HERBERT, R. W.; HIRST, E. L. (6 August 1932). "The ... Absorption Spectrum of Hexuronic Acid". Nature. 130 (3275): 205. doi:10.1038/130205a0. ISSN 1476-4687. This set index page ...
Table of Contents - October 14, 1932, 76 (1972) | Science
Forest Journal - Influence of Sulfate Cooking on Residual Lignin Content and Groups of Hexuronic Acid in Hardwood Pulp
vitamin C
Alternative Titles: ascorbic acid, cevitamic acid, hexuronic acid. Vitamin C, also called ascorbic acid, water-soluble, ... folic acid. folate, folacin, pteroylglutamic acid. component of coenzymes in DNA synthesis, metabolism of amino acids; required ... cofactor for enzymes in metabolism of amino acids (including folic acid) and fatty acids; required for new cell synthesis, ... ascorbic acid. antioxidant; synthesis of collagen, carnitine, amino acids, and hormones; immune function; enhances absorption ...
Engineering of Corynebacterium glutamicum for growth and production of L-ornithine, L-lysine, and lycopene from hexuronic acids...
Utilization of the hexuronic acids D-galacturonic acid (abundant in pectin-rich waste streams such as peels and pulps) and D- ... Heterologous expression of the genes for both uptake and catabolism of D-galacturonic acid and D-glucuronic acid was required ... Neither aldohexuronic acid supported growth of C. glutamicum as sole or combined carbon source, although its genome encodes a ... Corynebacterium glutamicum, which is used in industrial amino acid production at a million-ton scale, has been engineered ...
Plus it
hexuronic acid. ISPD. isoprenoid synthase domain containing. KO. knockout. LC. liquid chromatography. HexNAc. N-acetyl ... formic acid, and 50% acetonitrile/1% formic acid, dried down, and then redissolved in 0.1% formic acid for further cleaned up ... formic acid) in 60 min. Solvent A was 0.1% formic acid in water. The parameters used for MS and MS/MS data acquisition under ... glucuronic acid. Gro. glycerol. GroP. glycerol phosphate. HCD. higher-energy collisional dissociation. HRP. horseradish ...
Device design and materials optimization of conformal coating for islets of Langerhans
Development of a quantitative method for determination of the optimal conditions for protoplast isolation from cultured plant...
Identification, Genomic Organization, and Analysis of the Group III Capsular Polysaccharide Genes kpsD, kpsM,kpsT, and kpsE...
... hexuronic acids; N-acetyl neuraminic acid, phosphate, or 2-keto-3-deoxyoctonic acid (KDO) as acidic components; a higher charge ... an acidic component usually consisting of hexuronic acid or pyruvate, a low charge density and electrophoretic mobility, and ... Nucleotide sequence and deduced amino acid sequence ofkps K54 D,kps K54 M,kps K54 T, andkps K54 E. Arrows identify putative ... CLUSTAL alignment of the predicted amino acid sequences of E. coli kps K54 D (this study),kps K1 D, andkps K5 D. The boxed ...
Format: Text / Genre: Articles / Language: English - Albert Szent-Gyorgyi - Profiles in Science Search Results
Exhibit Tags: szeged / Creator: Cox, Gerald J. / Format: Text / Genre: Articles / Language: English / Publisher: American...
Vitamin C - Wikipedia
Haworth and Szent-Györgyi proposed that L-hexuronic acid be named a-scorbic acid, and chemically l-ascorbic acid, in honor of ... Ascorbic acid is a weak sugar acid structurally related to glucose. In biological systems, ascorbic acid can be found only at ... The biosynthesis of ascorbic acid in vertebrates starts with the formation of UDP-glucuronic acid. UDP-glucuronic acid is ... Vitamin C, also known as ascorbic acid and l-ascorbic acid, is a vitamin found in various foods and sold as a dietary ...
Flow behavior characteristics of ice cream mix made with buffalo milk and various stabilizers.
Glucuronic Acid. Gum Arabic / analysis. Hexuronic Acids. Ice Cream* / analysis. Karaya Gum / analysis. Mannans / analysis. Milk ... 0/Alginates; 0/Galactans; 0/Hexuronic Acids; 0/Mannans; 0/Plant Gums; 576-37-4/Glucuronic Acid; 9000-01-5/Gum Arabic; 9000-30-0 ... Previous Document: Protein digestibility using corrected amino acid score method (PDCAAS) of four types of mushrooms gr.... ...
Synthesis of a Kunitz-type serine proteinase inhibitory protein that shares homology with bovine pancreatic trypsin inhibitor...
Glucuronic Acid. Hexuronic Acids. Immunohistochemistry. Intervertebral Disk / cytology*, metabolism*. Peptides*. Plant Proteins ... 0/Alginates; 0/Culture Media, Serum-Free; 0/Hexuronic Acids; 0/Kunitz-type protease inhibitor, plant; 0/Peptides; 0/Plant ... Proteins; 0/Serine Proteinase Inhibitors; 0/Trypsin Inhibitors; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid; 9087-70-1/ ...
MEDLINE - Resultado p gina 1
0 (Alginates); 0 (Hexuronic Acids); 0 (Hydrogels); 0 (Ions); 0 (Magnetite Nanoparticles); 0 (Solutions); 0 (Uranium Compounds ... 0 (Alginates); 0 (Arsenates); 0 (Arsenites); 0 (Hexuronic Acids); 0 (Powders); 0 (Water Pollutants, Chemical); 0 (sericite); ... 0 (Water Pollutants, Chemical); 789U1901C5 (Copper); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); 9012-76-4 ( ... 7631-86-9 (Silicon Dioxide); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); E1UOL152H7 (Iron). ...
MEDLINE - Resultado p gina 1
Hexuronic Acids); 0 (Sclerosing Solutions); 339NCG44TV (Phenol); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid). ... These adverse effects have brought forward the use of chemical agents such as sodium hydroxide and trichloroacetic acid for ... The Effectiveness of Matrix Cauterization With Bichloracetic Acid in the Treatment of Ingrown Toenails.. ... bichloracetic acid (BCA) in the treatment of the ingrown nails. MATERIALS AND METHODS: A total of 30 patients with 58 ingrown ...
TNO Repository search for: subject:'Cell Culture Techniques'
Biology · Biomedical Research · alginic acid · cysteine · methionine · collagen · glucuronic acid · hexuronic acid · messenger ... Glucuronic Acid · Hexuronic Acids · Kinetics · Metacarpophalangeal Joint · Methionine · Protein Biosynthesis · Protein ... Glucuronic Acid, 576-37-4; Hexuronic Acids; Methionine, 63-68-3; Protein Synthesis Inhibitors; RNA, Messenger; Sulfur ... 5 methyltetrahydrofolic acid · caffeine · folate binding protein · folic acid · mannitol · article · cell growth · cell ...
Maria Serena Longhi, Ph.D., M.D. | Harvard Catalyst Profiles | Harvard Catalyst
Uronic acid - Wikipedia
Gluconic acid Glucuronic acid Isosaccharinic acid "Hexuronic acid". encyclopedia.com. Uronic+Acids at the US National Library ... the uronic acid analog of glucose is glucuronic acid. Uronic acids derived from hexoses are known as hexuronic acids and uronic ... Uronic acids (/ʊˈrɒnɪk/) are a class of sugar acids with both carbonyl and carboxylic acid functional groups. They are sugars ... while oxidation of both the terminal hydroxyl group and the aldehyde yields an aldaric acid. The names of uronic acids are ...
Albert von Szent-Gyorgyi facts, information, pictures | Encyclopedia.com articles about Albert von Szent-Gyorgyi
On the basis of these results Szent-Györgyi and Haworth changed the name hexuronic acid to ascorbic acid. ... He found that the reducing agent had the empirical composition C6H8O6, and he called it provisionally hexuronic acid. As the ... He had long thought that hexuronic acid was vitamin C, and he was now joined by J. Svirbely, who was experienced in the ... In 1929 he returned to Cambridge with 25 grams of hexuronic acid. Most of this he gave to (Sir) Norman Haworth of the ...
IJMS | Free Full-Text | In Vitro Antioxidant, Anticoagulant and Antimicrobial Activity and in Inhibition of Cancer Cell...
Xylan obtained exhibited total antioxidant activity corresponding to 48.5 mg of ascorbic acid equivalent/g of xylan. ... Dische, Z. A new specific color reactions of hexuronic acids. J. Biol. Chem 1974, 167, 189-198. [Google Scholar] ... Xyl: Xylose; Ara: Arabinose; Glc: Glucose; Gal: Galactose; Man: Mannose; Glu A: Glucuronic acid;aAnalyzed by HPLC after acid ... The antioxidant capacity was expressed as mg of ascorbic acid/g of polysaccharide, described as an ascorbic acid equivalent. ...
Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria | Journal of Bacteriology
Hexuronic acids d-galacturonic (d-GalA) and d-glucuronic acid (d-GlcA) are commonly found in all three domains of life. d-GalA ... d-Glucaric acid and meso-galactaric acid (also known as mucic acid) are natural products found in a variety of plants, ... The expanded GguR regulon is in agreement with reconstructed hexuronic acid catabolic pathways that have aldaric acids as ... Hexuronic and aldaric acids are naturally abundant six-carbon sugar acids that are often utilized as carbon and energy sources ...
Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with...
A) Characteristic disaccharide of HS consisting of a hexuronic acid and a glucosamine residue. The positions within the HS ... All identified HS6ST1 variants change amino acids that are perfectly conserved in HS6ST1s (Fig. 1B). The amino acids R296 and ... The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid ... First, all identified mutations affect amino acid residues that are highly conserved in HS6ST1 (Fig. 1B) and are absent from ...
Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity | Biochemical Journal
... hexuronic acid; VEGF, vascular endothelial growth factor; ΔUA, Δ-4,5-unsaturated UA ... Abbreviations: dp, degree of depolymerization; E, embryonic day; FGF, fibroblast growth factor; GlcA, glucuronic acid; GlcNAc, ... N-acetylglucosamine; GlcNS, N-sulfoglucosamine; HGF, hepatocyte growth factor; HS, heparan sulfate; IdoA, iduronic acid; m, ...
Scurvy - Wikipedia
... "hexuronic acid".[65] Szent-Györgyi suspected hexuronic acid, which he had isolated from adrenal glands, to be the antiscorbutic ... Because of this, hexuronic acid was subsequently renamed ascorbic acid. 21st century[edit]. Rates of scurvy in most of the ... In 1932, the connection between hexuronic acid and scurvy was finally proven by American researcher Charles Glen King of the ... Kings laboratory was given some hexuronic acid by Szent-Györgyi and soon established that it was the sought-after anti- ...
Kwas askorbinowy - Wikipedia, wolna encyklopedia
Wykazał, że wyodrębniony związek ma właściwości przeciwszkorbutowe i nadał mu nazwę „kwas heksauronowy" (hexuronic acid). W ... Oxalic acid excretion after intravenous ascorbic acid administration. „Metabolism". 58 (2), s. 263-269, 2009. DOI: 10.1016/j. ... Effect of large intake of ascorbic acid on urinary and plasma oxalic acid levels. „International Journal of Vitamin and ... a b Nutrients: Vitamin C, total ascorbic acid(mg). Food Groups: Finfish and Shellfish Products (ang.). W: USDA Food Composition ...
Category:Ascorbic acid - Wikimedia Commons
At the Mayo clinic, Szent-Györgyi had isolated the chemical hexuronic acid from animal adrenal glands. ... English: This category contains pictures of ascorbic acid (vitamin C is L-ascorbic acid) and its derivatives (isoascorbic acid ... Ascorbic-acid-vs-erythorbic-acid-2D-skeletal.png 2,000 × 1,879; 94 KB. ... Media in category "Ascorbic acid". The following 109 files are in this category, out of 109 total. ...
Age-Related Changes in Populations of Aortic Glycosaminoglycans | Arteriosclerosis, Thrombosis, and Vascular Biology
Contents are given in micrograms of hexuronic acid per milligram of dry, defatted tissue. Hexuronic acid content in total ... About 200 μg (as hexuronic acid) of aortic dermatan sulfate+chondroitin 4/6-sulfate, purified by Mono Q-FPLC (see Fig 2⇑), was ... Eluted fractions were analyzed by their metachromatic property29 and by their hexuronic acid content.28 On a control column, ... About 200 μg (as hexuronic acid) of the dermatan sulfate+chondroitin 4/6-sulfate-rich aortic proteoglycans (see Fig 7A⇑) (A) or ...
Frontiers | Vitamin C Content in Fruits: Biosynthesis and Regulation | Plant Science
In certain fruits and developmental conditions, an alternative pathway from D-galacturonic acid might be also relevant. We here ... a number of animals including humans have lost the ability to synthesize ascorbic acid (ascorbate, vitamin C), an essential ... a number of animals including humans have lost the ability to synthesize ascorbic acid (ascorbate, vitamin C), an essential ... Thus, that molecule, previously called hexuronic acid, was renamed as ascorbic acid. One of the main symptoms in scurvy is skin ...
Frontiers | Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules |...
Abbreviations: HexA, hexuronic acid (either glucuronic acid or iduronic acid); GlcNAc, N-acetyl-glucosamine; GlcN, glucosamine. ... HexA, hexuronic acid (either glucuronic or iduronic acid); GalNAc, N-acetyl-galactosamine (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 ... Heparin/HS is built up by repeating glucuronic acid (GlcUA)/iduronic acid (IdoUA)-N-acteylglucosamine (GlcNAc) disaccharide ... glucuronic acid; IdoUA, iduronic acid; GlcNAc, N-acteylglucosamine; GalNAc, N-acetylgalactosamine. ...
AscorbicGlucuronicUronic acidResiduesSugarsVitaminIdoAHexoseAlginicHeparanFolic acidFatty acidsCorresponding to amino acidsAdrenal glandsOrganicResiduePentoseAmino acidMannuronic acidOxidationHydrogelHyaluronicPolysaccharideMethylSugar acidsScurvyHexosesGlycosaminoglycansCollagenGlucosamineSulfate groupsCarboxylic acidPectinCarbohydratesProteinsCapsules
Ascorbic35
- In the early 1900s, ascorbic acid (vitamin C) was also known as hexuronic acid. (wikipedia.org)
- Vitamin C , also called ascorbic acid , water-soluble, carbohydrate-like substance that is involved in certain metabolic processes of animals. (britannica.com)
- l -ascorbic acid , is a vitamin found in various foods and sold as a dietary supplement . (wikipedia.org)
- Ascorbate and ascorbic acid are both naturally present in the body, since the forms interconvert according to pH . (wikipedia.org)
- Oxidized forms of the molecule such as dehydroascorbic acid are converted back to ascorbic acid by reducing agents. (wikipedia.org)
- Xylan obtained exhibited total antioxidant activity corresponding to 48.5 mg of ascorbic acid equivalent/g of xylan. (mdpi.com)
- Scurvy is a disease resulting from a lack of vitamin C (ascorbic acid). (wikipedia.org)
- [6] Ascorbic acid is needed for a variety of biosynthetic pathways, by accelerating hydroxylation and amidation reactions. (wikipedia.org)
- In the synthesis of collagen , ascorbic acid is required as a cofactor for prolyl hydroxylase and lysyl hydroxylase . (wikipedia.org)
- Throughout evolution, a number of animals including humans have lost the ability to synthesize ascorbic acid (ascorbate, vitamin C), an essential molecule in the physiology of animals and plants. (frontiersin.org)
- L-Ascorbic Acid (L-threo-hex-2-enono-1,4-lactone, ascorbate), also called vitamin C, is an essential antioxidant molecule in plant and animal metabolism and also functioning as a cofactor in many enzymes. (frontiersin.org)
- Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement. (nih.gov)
- In vitro studies have found that oxidized vitamin C, or dehydroascorbic acid, enters cells via some facilitated glucose transporters and is then reduced internally to ascorbic acid. (nih.gov)
- However, at doses above 1 g/day, absorption falls to less than 50% and absorbed, unmetabolized ascorbic acid is excreted in the urine [ 4 ]. (nih.gov)
- Results from pharmacokinetic studies indicate that oral doses of 1.25 g/day ascorbic acid produce mean peak plasma vitamin C concentrations of 135 micromol/L, which are about two times higher than those produced by consuming 200-300 mg/day ascorbic acid from vitamin C-rich foods [ 10 ]. (nih.gov)
- Pharmacokinetic modeling predicts that even doses as high as 3 g ascorbic acid taken every 4 hours would produce peak plasma concentrations of only 220 micromol/L [ 10 ]. (nih.gov)
- Ascorbic acid is a water soluble antioxidant. (naturalremedies.org)
- Ascorbic acid is also referred to as vitamin C. The sugar acid, ascorbic acid, is white or pale yellow. (naturalremedies.org)
- The name ascorbic acid originates from the word "scorbutus," which means "scurvy" and "a," which means "no. (naturalremedies.org)
- Walter Haworth discovered the ascorbic acid structure in 1937. (naturalremedies.org)
- At that time, ascorbic acid was referred to as hexuronic acid. (naturalremedies.org)
- Later, Albert Szent-Gyorgyi was awarded a prize in Medicine for his findings related to the functionality of L-ascorbic acid. (naturalremedies.org)
- Ascorbic acid is responsible for producing a protein in the body called collagen. (naturalremedies.org)
- Ascorbic acid aids the body in the healing of wounds, cuts, and abrasions. (naturalremedies.org)
- Ascorbic acid assists with these diseases by enlarging the blood vessels when consumed. (naturalremedies.org)
- Vitamin C or ascorbic acid comes in a variety of forms. (naturalremedies.org)
- While working at the University of Cambridge (1927, 1929) and at the Mayo Foundation, Rochester, Minn., U.S. (1928), Szent-Györgyi found and isolated an organic reducing agent, which he called hexuronic acid (now known as ascorbic acid), from plant juices and adrenal gland extracts. (britannica.com)
- In 1928 he isolated what he at first called "hexuronic acid," but is now called "ascorbic acid" or vitamin C. He also "discovered" the muscle protein actin, actomyosin and their relationship to ATP. (healthy.net)
- [7] There, Szent-Györgyi and his research fellow Joseph Svirbely found that "hexuronic acid" was actually the thus far unidentified antiscorbutic factor, known as vitamin C . After Walter Norman Haworth had determined the structure of vitamin C, and in honour of its antiscorbutic properties, it was given the formal chemical name of L-ascorbic acid . (wikipedia.org)
- For example, ascorbic acid functions as vitamin C for some animals but not others, and vitamins D and K are required in the human diet only in certain circumstances. (wikidoc.org)
- For example, ascorbic acid functions as vitamin C for some animals but not others. (thefullwiki.org)
- ಕೊನೆಗೆ ಆ ಆಮ್ಲಕ್ಕೆ ಕಅಸ್ಕಾರ್ಬಿಕ್ ಆಮ್ಲಕಿ (ascorbic acid) ಎಂದು ಕರೆಯಲಾಯಿತು.ಝೆಂಟ್-ಗಿಯೋಗ್ರ್ಯಿಯವರ ಈ ಸಂಶೋಧನೆ ಮುಂದೆ ಇತರ ವಿಜ್ಞಾನಿಗಳಾದ ವಾಲ್ಟರ್ ಹಾವರ್ತ್ (1883-1950) ಮತ್ತು ಪಾಲ್ ಕರೆರ್ (1889-1971) ಅವರುಗಳು ಅಸ್ಕಾರ್ಬಿಕ್ ಆಮ್ಲ ಅಥವಾ ಸಿ-ಜೀವಸತ್ವವನ್ನು (vitamin C) ಸಂಶ್ಲೇಷಿಸಲು ಸಾಧ್ಯವಾಯಿತು. (wikipedia.org)
- It was successfully synthesized, and the name was changed to ascorbic acid. (emailbliss.com)
- Vitamin C exists in nature in both its reduced form, l-ascorbic acid, and in its oxidized form, l-dehydroascorbic acid. (emailbliss.com)
- L-ascorbic acid is the most active form. (emailbliss.com)
Glucuronic20
- Utilization of the hexuronic acids D-galacturonic acid (abundant in pectin-rich waste streams such as peels and pulps) and D-glucuronic acid (a component of the side-chains of plant xylans) for growth and production with C. glutamicum has not yet been studied. (springeropen.com)
- Heterologous expression of the genes for both uptake and catabolism of D-galacturonic acid and D-glucuronic acid was required to enable growth of C. glutamicum with either aldohexuronic acid as the sole carbon source. (springeropen.com)
- The names of uronic acids are generally based on their parent sugars, for example, the uronic acid analog of glucose is glucuronic acid. (wikipedia.org)
- We used comparative genomics to reconstruct d -galacturonic and d -glucuronic acid catabolic pathways and associated transcriptional regulons involving the tripartite ATP-independent periplasmic (TRAP) family transporters that bind hexuronates in proteobacteria. (asm.org)
- Hexuronic acids d -galacturonic ( d -GalA) and d -glucuronic acid ( d -GlcA) are commonly found in all three domains of life. (asm.org)
- Heparin/HS is built up by repeating glucuronic acid (GlcUA)/iduronic acid (IdoUA)- N -acteylglucosamine (GlcNAc) disaccharide units whereas CS is built up by repeating GlcUA- N -acetylgalactosamine (GalNAc) disaccharide units ( 10 ). (frontiersin.org)
- d -glucuronic acid (GlcA) and l -iduronic acid (IdoA). (rupress.org)
- HS consists of repeating disaccharides, each of which is composed of hexuronic acid (glucuronic acid or iduronic acid) and N -acetylglucosamine. (nature.com)
- Naturally occurring uronic acids are D-glucuronic acid, D-galacturonic acid, L-iduronic acid and D-mannuronic acid. (rnrmarketresearch.com)
- Uronic acid residues can be either glucuronic or iduronic acid and substituted with 2- O -sulfo groups ( 3 , 4 ). (mcponline.org)
- Distinguishing glucuronic from iduronic acid in glycosaminoglycan tetrasaccharides by using electron detachment dissociation. (nih.gov)
- Distinguishing the epimers iduronic acid (IdoA) and glucuronic acid (GlcA) has been a long-standing challenge for the mass spectrometry analysis of glycosaminoglycan (GAG) oligosaccharides. (nih.gov)
- CS/DS polysaccharides are unbranched polymers consisting of repeated alternating hexuronic acid [either glucuronic acid (GlcA) or iduronic acid (IdoA)] and N -acetyl-galactosamime (GalNAc). (aacrjournals.org)
- All three enzymes catalyzed 6- O -sulfation of both N -acetylated (GlcNAc) as well as N -sulfated (GlcNS) glucosamines next to a nonreducing iduronic acid (IdoA) or glucuronic acid (GlcA). (diva-portal.org)
- Heparan sulfate (HS) chains attached to a core protein consist of alternating glucuronic acid and N-acetylglucosamine residues, which undergo a series of modifications, including sulfation, to produce mature long, unbranched HS chains. (biologists.org)
- Heparan sulphate (HS), one of the most abundant GAGs, is synthesised as a repeated disaccharide of glucosamine and glucuronic acid, which is modified by a variable series of reactions including sulphation. (biologists.org)
- The HS copolymer is attached to a core protein via a tetrasaccharide linkage and extended by alternate transfer from UDP-sugar donors of N-acetyl-D-glucosamine and D-glucuronic acid monomers. (biologists.org)
- Additionally, glucuronic acid may be modified by epimerisation of carbon 5 (C-5) to form iduronic acid. (biologists.org)
- The invention is also directed to the use of the receptor for diagnostics of Helicobacter pylori, to a method of producing chondroitin oligosaccharides from chondroitin sulphates, and a method for production of amidated glucuronic acid comprising oligosaccharides and monosaccharides from glucuronic acid comprising polysaccharides. (sumobrain.com)
- It is also present in heparan sulfate although here in a minor amount relative to its carbon-5 epimer glucuronic acid . (chemeurope.com)
Uronic acid4
- Hexuronic acid is any uronic acid derived from a hexose. (wikipedia.org)
- It is also a uronic acid or hexuronic acid. (rnrmarketresearch.com)
- Heparin (Hp) 1 and heparan sulfate (HS) are linear, polydisperse, and highly sulfated glycosaminoglycans (GAGs), with a repeating disaccharide building block composed of a 1-4-linked glucosamine and a uronic acid residue ( 1 ). (mcponline.org)
- L- Iduronic acid (IdoA) is the major uronic acid component of the glycosaminoglycans (GAGs) dermatan sulfate and heparin . (chemeurope.com)
Residues4
- During biosynthesis, its sugar backbone undergoes extensive sulfation at some of the 2- O -positions of iduronic acids and the 3- O -, 6- O -, and N -positions of glucosamine residues. (nature.com)
- In contrast, HS from glucuronyl C5-epimerase mutants, which is extensively N- and 6- O- sulfated, but lacks 2- O -sulfated L-iduronic acid residues, retained PDGF-BB in vitro, and pericyte recruitment in vivo was only transiently delayed. (diva-portal.org)
- Alginate is a linear, anionic polysaccharide consisting of two form of 1, 4-linked hexuronic acid residues, β-d-mannuronopyranosyl (M) and α-l- guluronopyranosyl (G) residues. (chemicalbook.com)
- Sodium alginate consists mainly of the sodium salt of alginic acid, which is a mixture of polyuronic acids composed of residues of D-mannuronic acid and L-guluronic acid. (steunmijnclub.nl)
Sugars6
- This bacterium is capable of utilizing various sugars as well as organic acids [ 2 ]. (springeropen.com)
- They are sugars in which the terminal carbon's hydroxyl group has been oxidized to a carboxylic acid. (wikipedia.org)
- Surface analysis with XPS revealed no significant changes in the surface structure of the dried MFC cakes but the filtrates after the hydrothermal treatment were complex mixtures of sugars, organic acids and furans. (springer.com)
- It contains sugars such as 2-keto-3-deoxy-d-lyxo-heptulosaric acid (Dha) and 2-keto-3-deoxy-d-manno-octulosonic acid (Kdo), and within the wall RG-II is mostly found as a dimer via a borate diester cross-link. (jove.com)
- The human body is made up of chemical compounds such as water, amino acids (proteins), fatty acids (lipids), nucleic acids (DNA/RNA), and carbohydrates (e.g. sugars and fiber). (consumersresearchcncl.org)
- In carbohydrate science , Sugar Acids , as an acyclic acid , are acidic sugars. (wellnessadvocate.com)
Vitamin9
- [3] Doing so converts vitamin C to an oxidized state - either as semidehydroascorbic acid or dehydroascorbic acid . (wikipedia.org)
- He had long thought that hexuronic acid was vitamin C, and he was now joined by J. Svirbely, who was experienced in the necessary animal tests. (encyclopedia.com)
- The physiologic importance of dehydroascorbic acid uptake and its contribution to overall vitamin C economy is unknown. (nih.gov)
- Hungarian-American biochemist who was awarded the 1937 Nobel Prize for Physiology or Medicine for his discoveries in connection with the biological combustion processes, with special reference to vitamin C and the catalysis of fumaric acid. (todayinsci.com)
- Four years later, as a professor at the University of Szeged, Hungary (1931-45), he helped prove that the acid is identical to the antiscurvy vitamin C, which had been discovered in 1907 by Axel Holst and Alfred Fröhlich. (britannica.com)
- He was awarded the Nobel Prize in Medicine in 1937 for his discovery of the biological oxidation process with special regard to vitamin C and fumaric acid catalysis. (healthy.net)
- [1] He is credited with first isolating vitamin C and discovering the components and reactions of the citric acid cycle . (wikipedia.org)
- In some experiments they used paprika as the source for their vitamin C. Also during this time, Szent-Györgyi continued his work on cellular respiration, identifying fumaric acid and other steps in what would become known as the Krebs cycle . (wikipedia.org)
- The term vitamin does not include other essential nutrients such as dietary minerals , essential fatty acids , or essential amino acids , nor does it encompass the large number of other nutrients that promote health but that are not essential for life. (wikidoc.org)
IdoA2
- The unique feature that distinguishes DS from CS is the presence of iduronic acid (IdoA) in DS. (aacrjournals.org)
- IdoA may be modified by the addition of a O-sulfate group at carbon position 2 to form 2-O-sulfo-L-iduronic acid (IdoA2S). (chemeurope.com)
Hexose2
- The major GIPC has one hexose residue, one hexuronic acid residue, inositol phosphate, and a ceramide moiety with a C18 trihydroxylated mono-unsaturated long-chain base and a C24 monohydroxylated saturated fatty acid. (jove.com)
- and confirming that the tetrasaccharide repeating unit of Escherichia coli serotype K9 is composed of two hexoses, one acetamido hexose and one N-acetyl neuraminic acid. (ubc.ca)
Alginic3
- Breaks down alginate or alginic acid to smaller molecules and reduces viscosity. (steunmijnclub.nl)
- Sodium alginate is the sodium salt of alginic acid, which is a polyuronide made up of a sequence of two hexuronic acids: beta-D mannuronic acid and alpha-L guluronic acid. (steunmijnclub.nl)
- The chemical compound Sodium Alginate is the sodium salt of alginic acid. (steunmijnclub.nl)
Heparan2
- Changes in the content of hyaluronic acid and heparan sulfate are less noticeable. (ahajournals.org)
- 1996 ). An animal cell mutant defective in heparan sulfate hexuronic acid 2-0-sulfation. (biologists.org)
Folic acid3
- For example, folic acid carries various forms of carbon group - methyl , formyl and methylene - in the cell. (wikidoc.org)
- folinic acid (foh- lin -ik) n. a derivative of folic acid involved in purine synthesis. (encyclopedia.com)
- more stable to oxidation than folic acid itself, and commonly used in pharmaceutical preparations. (encyclopedia.com)
Fatty acids1
- For example, biotin is part of enzymes involved in making fatty acids . (wikidoc.org)
Corresponding to amino acids1
- The white bar represents the signal peptide, corresponding to amino acids 1-68. (prolekare.cz)
Adrenal glands2
- At the Mayo clinic, Szent-Györgyi had isolated the chemical hexuronic acid from animal adrenal glands. (wikimedia.org)
- It was first isolated by Albert Szent-Gyorgyi in 1928 from pork adrenal glands and called hexuronic acid. (emailbliss.com)
Organic3
- He received his PhD from Fitzwilliam College, Cambridge in 1927 for work on isolating an organic acid , which he then called "hexuronic acid", from adrenal gland tissue. (wikipedia.org)
- In organic chemistry , Acyclic Acids (Ethanoic Acids) , as organic compounds are 2 carbon straight-chain saturated carboxylic acids , that have an open-chain molecular structures as opposed to ring-shaped structures. (wellnessadvocate.com)
- The changes in the concentrations of sugar, alcohol, organic acids, and flavor compounds were analyzed using gas chromatography-mass spectrometry (GC-MS) and high pressure liquid chromatography (HPLC). (bvsalud.org)
Residue1
- A ) Characteristic disaccharide of HS consisting of a hexuronic acid and a glucosamine residue. (pnas.org)
Pentose1
- We found that only mutations in sugar pathways affected colonization, not phospholipid and amino acid catabolism, not gluconeogenesis, not the tricarboxylic acid cycle, and not the pentose phosphate pathway. (pnas.org)
Amino acid3
- Corynebacterium glutamicum , which is used in industrial amino acid production at a million-ton scale, has been engineered towards utilization of alternative carbon sources. (springeropen.com)
- Protein digestibility using corrected amino acid score method (PDCAAS) of four types of mushrooms gr. (biomedsearch.com)
- In protein science , an Imino Acid (Secondary Amino Acid) is a molecule, related to amino acids (differing in the bonding to the nitrogen), that contains both an imino (>C=NH) and a carboxyl (-C(=O)-OH) functional group, which occurs as either an acyclic acid or a cyclic imino acid . (wellnessadvocate.com)
Mannuronic acid1
- Aly-SJ02 showed activities toward both polyG (α-l-guluronic acid) and polyM (β-D-mannuronic acid), indicating that it is a bifunctional alginate lyase. (nih.gov)
Oxidation1
- Oxidation of the terminal aldehyde instead yields an aldonic acid, while oxidation of both the terminal hydroxyl group and the aldehyde yields an aldaric acid. (wikipedia.org)
Hydrogel1
- AJOU Open Repository: Mechanical stimulation by ultrasound enhances chondrogenic differentiation of mesenchymal stem cells in a fibrin-hyaluronic acid hydrogel. (ajou.ac.kr)
Hyaluronic2
- Serum Levels of glycosaminoglycans and chondroitin sulfate/hyaluronic acid disaccharides as diagnostic markers for liver diseases. (thefreedictionary.com)
- This study investigated whether or not fibrin-hyaluronic acid (HA) coupled with low-intensity ultrasound (LIUS), a mechanical stimulation, produces an additive or synergistic effect on the chondrogenesis of rabbit mesenchymal stem cells (MSCs) derived from bone marrow. (ajou.ac.kr)
Polysaccharide1
- The HS polysaccharide is composed of alternating hexuronic acid and d -glucosamine units and is substituted with sulfate groups in various positions. (rupress.org)
Methyl1
- Aspinall , G. O.: The methyl ethers of hexuronic acids. (springer.com)
Sugar acids1
- Uronic acids (/ʊˈrɒnɪk/) are a class of sugar acids with both carbonyl and carboxylic acid functional groups. (wikipedia.org)
Scurvy1
- In April 1932 they announced that they had, by the administration of one milligram of hexuronic acid daily, protected guinea pigs from scurvy for 56 days. (encyclopedia.com)
Hexoses1
- Uronic acids derived from hexoses are known as hexuronic acids and uronic acids derived from pentoses are known as penturonic acids. (wikipedia.org)
Glycosaminoglycans2
- This fine technology brings more sensitive, specific, and reliable methods than the previous biochemical ones for the analysis of urinary glycosaminoglycans, oligosaccharides, and sialic acid. (springer.com)
- Glycosaminoglycans (GAGs) are linear polymers of repeated disaccharides, in most cases containing an O-sulphated N-acetylhexosamine and an hexuronic acid, commonly expressed in a variety of tissues. (thefreedictionary.com)
Collagen1
- 2. Soaking the particulate collagen in dilute acetic acid. (google.com)
Glucosamine1
- These HS chains are linear glycosaminoglycan polysaccharides of variable length ( n = 50-150) composed of hexuronic acid and glucosamine repeat units. (genetics.org)
Sulfate groups1
- To address their structure, the nature of the hexuronic acids and the position of sulfate groups must be determined. (infona.pl)
Carboxylic acid1
- 1] In its open form, it has an aldehyde group at C1 and a carboxylic acid group at C6. (rnrmarketresearch.com)
Pectin2
- Among the sugar constituents of plant cell wall are the hexuronic acids D-galacturonate and D-glucuronate found in pectin. (springeropen.com)
- It is the main component of pectin, in which it exists as the polymer polygalacturonic acid. (rnrmarketresearch.com)
Carbohydrates1
- On analyzing the chemical composition of reed fibers, extractives of lignin, carbohydrates, uronic acids and minerals were reported. (scielo.br)
Proteins2
- Amino acids 1-68 represent an atypical signal peptide and direct the pre-pro-proteins to the Sec apparatus, where they are cleaved by signal peptidase I [18] . (prolekare.cz)
- The resulting pro-proteins are targeted to the HMW1B and HMW2B outer membrane translocators and undergo cleavage between amino acids 441 and 442, removing the pro-pieces and generating mature species that are 125 kDa and 120 kDa, respectively [18] - [21] ( Figure 1A ). (prolekare.cz)
Capsules1
- 100,000), an acidic component usually consisting of hexuronic acid or pyruvate, a low charge density and electrophoretic mobility, and stability at pH 5 to 6 at 100°C. Group I capsules may protect against desiccation and may contribute to adherence in enteric disease-producing isolates of E. coli ( 17 , 27 , 30 ). (asm.org)