An enzyme that catalyzes the synthesis of fructose-6-phosphate plus GLUTAMINE from GLUTAMATE plus glucosamine-6-phosphate.
SUGARS containing an amino group. GLYCOSYLATION of other compounds with these amino sugars results in AMINOGLYCOSIDES.
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
The sum of the weight of all the atoms in a molecule.
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
Serum proteins that have the most rapid migration during ELECTROPHORESIS. This subgroup of globulins is divided into faster and slower alpha(1)- and alpha(2)-globulins.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood fluidity, and BLOOD COAGULATION. Majority of the hemostatic disorders are caused by disruption of the normal interaction between the VASCULAR ENDOTHELIUM, the plasma proteins (including BLOOD COAGULATION FACTORS), and PLATELETS.
Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).
The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.
Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
A circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. It occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Rare autosomal recessive syndrome of extreme insulin resistance due to mutations in the binding domain of INSULIN RECEPTOR. Clinical features include severe intrauterine and postnatal growth restriction, characteristic dysmorphic FACIES; HIRSUTISM; VIRILIZATION; multiple endocrine abnormalities, and early death.
Two off-spring from the same PREGNANCY. They are from a single fertilized OVUM that split into two EMBRYOS. Such twins are usually genetically identical and of the same sex.
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share in common an N-terminal PHOSPHOLIPID-binding domain, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation insulin receptor substrate proteins interact with specific SH2 DOMAIN-containing proteins that are involved in insulin receptor signaling.
The N-acetyl derivative of glucosamine.
Enzymes that catalyze the transfer of N-acetylglucosamine from a nucleoside diphosphate N-acetylglucosamine to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
Time period from 1901 through 2000 of the common era.
Serves as the biological precursor of insect chitin, of muramic acid in bacterial cell walls, and of sialic acids in mammalian glycoproteins.
Compounds consisting of glucosamine and lactate joined by an ether linkage. They occur naturally as N-acetyl derivatives in peptidoglycan, the characteristic polysaccharide composing bacterial cell walls. (From Dorland, 28th ed)
A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
Excision of kidney.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.
A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.

Distribution of chondroitin sulfate in cartilage proteoglycans under associative conditions. (1/793)

Proteoglycan aggregates and proteoglycan subunits were extracted from bovine articular cartilage with guanidine-HC1 folowed by fractionation by equilibrium centrifugation in cesium chloride density gradients. The distribution of chondroitin sulfates (CS) in the cartilage proteoglycans was studied at the disaccharide level by digestion with chondroitinases. In the proteoglycan aggregate fraction, it was observed that the proportion of 4-sulfated disaccharide units to total CS increased from the bottom to the top fractions, whereas that of 6-sulfated disaccharide units was in the reverse order. Thus, the ratio of 4-sulfated disaccharide units to 6-sulfated disaccharide units increased significantly with decreasing density. The proportion of non-sulfated disaccharide units to total CS tended to increase with increasing density. These data indicate a polydisperse distribution of CS chains, under the conditions used here, in proteoglycan aggregates from bovine articular cartilage.  (+info)

A comparative chemical and histochemical study of the chondrodystrophoid and nonchondrodystrophoid canine intervertebral disc. (2/793)

The chemical composition of the intervertebral disc of 9-month-old chondrodystrophoid and nonchondrodystrophoid dogs was studied for collagen, noncollagenous protein and glycosaminoglycan. Content of these substances differed significantly between breeds. The differences were most marked in the nucleus pulposus; the noncollagenous protein content of the nonchondrodystrophoid breed was higher than in that of the chondrodystrophoid dogs. The total nitrogen value of the nonchondrodystrophoid nuclei pulposi was less than that of the corresponding chondrodystrophoid discs mainly because of the high collagen content of the latter discs. Histochemically, it was found that the nuclei pulposi of the nonchondrodystrophoid breed contains larger amounts of glycosaminoglycan than in the discs of the chondrodystrophoid breeds.  (+info)

Decreased hexosamine biosynthesis in GH-deficient dwarf rat muscle. reversal with GH, but not IGF-I, therapy. (3/793)

Enhanced glucose flux via the hexosamine biosynthesis pathway (HNSP) has been implicated in insulin resistance. We measured L-glutamine:D-fructose-6-phosphate amidotransferase activity (GFAT, a rate-limiting enzyme) and concentrations of UDP-N-acetyl hexosamines (UDP-HexNAc, major products of HNSP) in muscle and liver of growth hormone (GH)-deficient male dwarf (dw) rats. All parameters measured, except body weight, were similar in 5-wk-old control and dw rats. Muscle GFAT activity declined progressively with age in controls and dw rats but was consistently 30-60% lower in 8- to 14-wk-old dw rats vs. age-matched controls; UDP-HexNAc concentrations in muscle were concomitantly 30% lower in dw rats vs. controls (P < 0.01). Concentrations of UDP-hexoses, GDP-mannose, and UDP in muscle were similar in control and dw rats. Muscle HNSP activity was similarly diminished in fed and fasted dw rats. In liver, only a small difference in GFAT activity was evident between controls and dw rats, and no differences in UDP-HexNAc concentrations were observed. Treatment with recombinant human GH (rhGH) for 5 days restored UDP-HexNAc to control levels in dw muscles (P < 0.01) and partially restored GFAT activity. Insulin-like growth factor I treatment was ineffective. We conclude that GH participates in HNSP regulation in muscle.  (+info)

Quantitative determination of N-acetylglucosamine residues at the non-reducing ends of peptidoglycan chains by enzymic attachment of [14C]-D-galactose. (4/793)

The ability of human milk galactosyltransferase to attach D-galactose residues quantitatively to the C-4 of N-acetylglucosamine moieties at the ends of oligosaccharides has been utilized for the specific labeling and quantitative determination of the chain length of the glycan moiety of the bacterial cell wall. The average polysaccharide chain length of the soluble, uncrosslinked peptidoglycan secreted by Micrococcus luteus cells on incubation with penicillin G was studied with this technique and found to be approximately 70 hexosamines long. Furthermore, the peptidoglycan chain length of Escherichia coli sacculi of different cell shapes and dimensions was determined both in rod-shaped cells and in filaments induced by temperature shift of a division mutant or by addition of cephalexin or nalidixic acid. The average chain length found in most of these sacculi was between 70 and 100 hexosamines long. Small spherical 'mini' cells had chain lengths similar to those of the isogenic rod-like cells.  (+info)

Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function. (5/793)

We noted previously that certain aminoglycoside antibiotics inhibit the binding of coatomer to Golgi membranes in vitro. The inhibition is mediated in part by two primary amino groups present at the 1 and 3 positions of the 2-deoxystreptamine moiety of the antibiotics. These two amines appear to mimic the epsilon-amino groups present in the two lysine residues of the KKXX motif that is known to bind coatomer. Here we report the effects of 1, 3-cyclohexanebis(methylamine) (CBM) on secretion in vivo, a compound chosen for study because it contains primary amino groups that resemble those in 2-deoxystreptamine and it should penetrate lipid bilayers more readily than antibiotics. CBM inhibited coatomer binding to Golgi membranes in vitro and in vivo and inhibited secretion by intact cells. Despite depressed binding of coatomer in vivo, the Golgi complex retained its characteristic perinuclear location in the presence of CBM and did not fuse with the endoplasmic reticulum (ER). Transport from the ER to the Golgi was also not blocked by CBM. These data suggest that a full complement of coat protein I (COPI) on membranes is not critical for maintenance of Golgi integrity or for traffic from the ER to the Golgi but is necessary for transport through the Golgi to the plasma membrane.  (+info)

Decreased insulin-stimulated GLUT-4 translocation in glycogen-supercompensated muscles of exercised rats. (6/793)

It was recently found that the effect of an exercise-induced increase in muscle GLUT-4 on insulin-stimulated glucose transport is masked by a decreased responsiveness to insulin in glycogen-supercompensated muscle. We evaluated the role of hexosamines in this decrease in insulin responsiveness and found that UDP-N-acetyl hexosamine concentrations were not higher in glycogen-supercompensated muscles than in control muscles with a low glycogen content. We determined whether the smaller increase in glucose transport is due to translocation of fewer GLUT-4 to the cell surface with the 2-N-4-(1-azi-2,2,2-trifluroethyl)-benzoyl-1, 3-bis(D-mannose-4-yloxy)-2-propylamine (ATB-[2-3H]BMPA) photolabeling technique. The insulin-induced increase in GLUT-4 at the cell surface was no greater in glycogen-supercompensated exercised muscle than in muscles of sedentary controls and only 50% as great as in exercised muscles with a low glycogen content. We conclude that the decreased insulin responsiveness of glucose transport in glycogen-supercompensated muscle is not due to increased accumulation of hexosamine biosynthetic pathway end products and that the smaller increase in glucose transport is mediated by translocation of fewer GLUT-4 to the cell surface.  (+info)

Multiple enzymatic activities of the murein hydrolase from staphylococcal phage phi11. Identification of a D-alanyl-glycine endopeptidase activity. (7/793)

Bacteriophage muralytic enzymes degrade the cell wall envelope of staphylococci to release phage particles from the bacterial cytoplasm. Murein hydrolases of staphylococcal phages phi11, 80alpha, 187, Twort, and phiPVL harbor a central domain that displays sequence homology to known N-acetylmuramyl-L-alanyl amidases; however, their precise cleavage sites on the staphylococcal peptidoglycan have thus far not been determined. Here we examined the properties of the phi11 enzyme to hydrolyze either the staphylococcal cell wall or purified cell wall anchor structures attached to surface protein. Our results show that the phi11 enzyme has D-alanyl-glycyl endopeptidase as well as N-acetylmuramyl-L-alanyl amidase activity. Analysis of a deletion mutant lacking the amidase-homologous sequence, phi11(Delta181-381), revealed that the D-alanyl-glycyl endopeptidase activity is contained within the N-terminal 180 amino acid residues of the polypeptide chain. Sequences similar to this N-terminal domain are found in the murein hydrolases of staphylococcal phages but not in those of phages that infect other Gram-positive bacteria such as Listeria or Bacillus.  (+info)

Uptake of N-acetyl-D-mannosamine: an essential intermediate in polysialic acid biosynthesis by Escherichia coli K92. (8/793)

The N-acetyl-D-mannosamine (ManNAc) transport system of Escherichia coli K92 was studied when this bacterium was grown in a chemically defined medium containing ManNAc as carbon source. Kinetic measurements were carried out in vivo at 37 degrees C in 25 mM phosphate buffer, pH 7.5. Under these conditions, the uptake rate was linear for at least 15 min and the calculated Km for ManNAc was 280 microM. The transport system was strongly inhibited by sodium arsenate (97%), potassium cyanide (84%) and 2,4-dinitrophenol (88%) added at final concentrations of 1 mM (each). Analysis of bacterial ManNAc phosphotransferase activity revealed in vitro ManNAc phosphorylation activity only when phosphoenolpyruvate was present. These results strongly support the notion that ManNAc uptake depends on a specific phosphotransferase system. Study of specificities showed that N-acetylglucosamine and mannosamine specifically inhibited the transport of ManNAc in this bacterium. Analysis of expression revealed that the ManNAc transport system was induced by ManNAc, glucosamine, galactosamine, mannosamine and mannose but not by N-acetylglucosamine or N-acetylgalactosamine. Moreover, ManNAc permease was subject to glucose repression and cAMP stimulation. Full induction of the ManNAc transport system required the simultaneous presence of both cAMP and ManNAc.  (+info)

B.Tech. Biochemical Engineering or Bachelor of Technology in Biochemical Engineering is an undergraduate Biochemical Engineering course.. Biochemical engineering is a branch of chemical engineering or biological engineering. The course deals with the design and construction of unit processes that involve biological organisms or molecules, such as bioreactors.. ...
Moritz Wüstenber graduated from the UCL Department of Biochemical Engineering in 2011. He and his company are profiled in an article in The Chemical Engineer. Helen Tunnicliffe spoke to him about his journey from degree studies to setting up Northern Lights Spirits, a craft gin distiller based in north Karelia in eastern Finland. Read the the article here.... The Chemical Engineer features views and jobs from the chemical, biochemical and process engineering sectors and is a subscription-only journal so were very grateful to them for sharing this article with us. This is a list of places where you can find Kalevala Gin in the UK, you can find out more about studying with the UCL Department of Biochemical Engineering here.. ...
View the list of chemicals for biochemical engineering to find quality suppliers. Echemi helps you to buy various biochemicals used in biochemical engineering.
The development of eco-efficient processes for sustainable industrial chemical and biochemical engineering involves three core areas: 1. Development of last generation separation technologies The development of novel separation systems includes those that allow the recovery of different compounds present in mixtures (e.g., high added-value compounds) or the maximization of the
The goal of the Business and Science Chemical and Biochemical Engineering program from Rutgers University is to educate students in the essential skills
Pikamilone, find complete details about Pikamilone, Biochemical Engineering, nucleic acid drugs, Heterocycles - Baoji GuoKang Bio-Technology Co., Ltd.
The journal serves as a forum to keep informed on biochemical engineering applications useful in the food, feed, pharmaceutical, biotechnology, and...
The journal serves as a forum to keep informed on biochemical engineering applications useful in the food, feed, pharmaceutical, biotechnology, and...
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Pancreatic ductal adenocarcinoma (PDAC) is considered to be a highly immunosuppressive and heterogenous neoplasm. Despite improved knowledge regarding the genetic background of the tumor and better understanding of the tumor microenvironment, immune checkpoint inhibitor therapy (targeting CTLA4, PD1, PDL1) has not been very successful against PDAC. The robust desmoplastic stroma, along with an extensive extracellular matrix (ECM) that is rich in hyaluronan, plays an integral role in this immune evasion. Hexosamine biosynthesis pathway (HBP), a shunt pathway of glycolysis, is a metabolic node in cancer cells that can promote survival pathways on one hand and influence the hyaluronan synthesis in the ECM on the other. The rate-limiting enzyme of the pathway, glutamine-fructose amidotransferase (GFAT1), uses glutamine and fructose 6-phosphate to eventually synthesize UDP-GlcNAc. In the current manuscript, we targeted this glutamine-utilizing enzyme by a small molecule glutamine analog ...
The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format. By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. To select a subset of the search results, click Selective Export button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export. After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format. ...
Carbohydrates, through the process of glycoconjugation, play a vital role in a number of important eukaryotic cell signalling processes. Professor Valentin Wittmann and his team at the University of…
Glentham Life Sciences is a supplier of GC1764 - D-Mannosamine hydrochloride (5505-63-5). View catalogue prices, chemical data, technical specifications and MSDS documents.
Describes how a fructosamine (glycated serum protein) test is used, when a fructosamine test is ordered, and what the results of a fructosamine test might mean
The hexosamine biosynthetic pathway, whose end product is UDP-N acetylglucosamine (UDP-GlcNAc), lies at the base of cellular glycosylation pathways, including glycosylation of lipids, formation of heparin sulfated proteoglycans, and N- and O-linked glycosylation of proteins. Forward genetic studies in Drosophila have revealed that mutations in genes encoding different enzymes of the hexosamine biosynthetic pathway result in reduction of UDP-GlcNAc to different extents, with a consequent disruption of distinct glycosylation pathways and developmental processes. A maternal and zygotic loss-of-function screen has identified mutations in nesthocker (nst), which encodes an enzyme in the hexosamine biosynthetic pathway. Embryos lacking maternal and zygotic nst gene products show defective O-GlcNAcylation of a fibroblast growth factor receptor (FGFR)-specific adaptor protein, which impairs FGFR-dependent migration of mesodermal and tracheal cells.. ...
People who are searching for Free downloads of books and free pdf copies of these books - Human Blood Groups: Chemical and Biochemical Basis of Antigen Specificity by Helmut Schenkel-Brunner, Techniques in Diagnostic Human Biochemical Genetics: A Laboratory Manual by Frits A Hommes, Biochemical Individuality by Roger Williams, Bioreactor Systems for Tissue Engineering II: Strategies for the Expansion and Directed Differentiation of Stem Cells (Advances in Biochemical Engineering/Biotechnology) by Martijn van Griensven and Cornelia Kasper, Nano/Micro Biotechnology (Advances in Biochemical Engineering/Biotechnology) by Isao Endo and Teruyuki Nagamune, Biosensing for the 21st Century (Advances in Biochemical Engineering/Biotechnology) by Fred Lisdat, Reverse Chemical Genetics: Methods and Protocols: 577 (Methods in Molecular Biology) by Hisashi Koga, Genetics and Genomics for the Cardiologist (Basic Science for the Cardiologist) by Gian Antonio Danieli, Practical Bioinformatics ...
Poly-α2,8-sialic acid (PSA) has been implicated in numerous normal and pathological processes, including development, neuronal plasticity, and tumor metastasis. We report that cell surface PSA expression can be reversibly inhibited by a small molecule,N-butanoylmannosamine (ManBut). Inhibition occurs through a metabolic mechanism in which ManBut is converted to unnatural sialic acid derivatives that effectively act as chain terminators during cellular PSA biosynthesis. N-Propanoylmannosamine (ManProp), which differs from ManBut by a single methylene group, did not inhibit PSA biosynthesis. Modulation of PSA expression by chemical means has a role complementary to genetic and biochemical approaches in the study of complex PSA-mediated events. ...
Glukosamin pertama kali diidentifikasi oleh Dr. Georg Ledderhose pada tahun 1876, tetapi struktur stereokimia tidak sepenuhnya diketahui sampai ditemukan oleh Walter Haworth pada tahun 1939.[1] D-Glukosamin dibuat secara alami dalam bentuk glukosamin-6-fosfat, dan merupakan prekursor biokimia dari semua gula yang mengandung nitrogen.[2] Specifically, glucosamine-6-phosphate is synthesized from fructose-6-phosphate and glutamine[3] as the first step of the hexosamine biosynthesis pathway.[4] Produk akhir dari lintasan ini adalah UDP-N-asetilglukosamin (UDP-GlcNAc), yang kemudian digunakan untuk membentuk glikosaminoglikan, proteoglikan, dan glikolipid. Pembentukan glukosamin-6-fosfat merupakan tahap awal untuk menyintesis produk ini. Glukosamin merupakan komponen penting dalam meregulasi produksi senyawa tersebut. Walaupun demikian, bagaimana lintasan biosintesis heksoamin diregulasi dan bagaimana hal ini dapat berpengaruh terhadap penyakit manusia masih belum terlalu jelas [5] ...
This dataset relates to the Product level embodied carbon flows in bilateral trade research article.. An extensive data search was conducted and product carbon intensity factors were collected from multiple data sources as part of this research. The constructed dataset covers over 1000 products and is made available for download publicly on this website. The original data are provided by the Global Footprint Network (GFN), European Unions ELCD and many other sources. The procedures used to construct the dataset are documented in the accompanying publication, as are the full set of original data sources.. Download the Product level carbon intensities dataset. ...
Bioprocess engineering: Structure of prokaryotic and eukaryotic cells, cell components, elemental composition of cells, metabolic pathways (repetition), uptake system, membranepotential, basic functions of a bioreactor, types of bioreactors, agitation and oxygen transfer, upstream processing, sterilization techniques, bioprocess automation, PAT, Liebigs law, mass and energy balances, oxygen requirements, yield coefficients, requirements for a successful batch, growth kinetics, Monod kinetics, stoichiometric model, integral medium design, microbial growth on defined and complex media, substrate inhibition, cell physiology of nutrient limited batch cultures, batch growth extended, direct and indirect estimation of biomass, feed strategies, product formation, high cell-density fed-batches, chemostat, nutrient limitation, wash-out, optimal productivity, growth physiology, two-stage chemostat.. Downstream processing: significance of DSP; chemical and biotechnological DSP; biomolecules; purity; ...
The aim of the course is to provide students with an understanding of the industrial relevance of common biochemical processes and to allow them to model, analyse, and design such systems.. This course introduces the fundamentals of microbiology and biochemistry, the main cell constituents, DNA, RNA, enzymes, membranes. The kinetics of enzymatic reaction and of microbial growth is reviewed. The mass and heat transfer theory developed as part of other courses is applied to biochemical process. The design methodology for biochemical processes is described. Typical biochemical processes are described, including beer, whisky, penicillin, monoclonal antibody, wastewater treatment. ...
This category contains many products, and so has been restricted to showing only the most popular items.. To search all items within the category, enter a search term in the refine box below. ...
Hip resurfacing arthroplasty (HRA) utilizing metal-on-metal bearings is a longtime yet specialized procedure in joint surgical procedure. in line with the event of major specialists within the box, The hip resurfacing guide offers a entire reference for all points of this significant procedure.. The first a part of the publication reports and compares the entire significant hip resurfacing prostheses, their key layout beneficial properties, suitable surgical concepts and medical effects. half discusses medical follow-up of the hip resurfacing sufferer, together with pre- and post-operative exam, acoustic phenomena and rehabilitation. It additionally covers using concepts comparable to radiography and steel ion size, in addition to bone scans, ultrasound, CT, MRI, puppy and DEXA, to judge hip resurfacings. half 3 studies most sensible perform in surgical strategy, together with the transformed posterior and anterior methods, in addition to instrumentation, anaesthesia and revision surgical ...
Biological ammonium oxidation was carried out in an inverse turbulent bed reactor fed with a synthetic mineral wastewater containing a high ammonium concentration (250 or 500 mg N-NH4 +/L). The effects of dissolved oxygen concentration in the reactor, of ammonium concentration in the feeding and of ammonium loading rate on nitrite accumulation was studied in order to optimize ammonium conversion. A model of the biofilm was proposed to describe the experiments and to predict the effects of some operating parameters on nitrite accumulation. The model could also describe oxygen concentration gradients in the biofilm in steady-state conditions. It was shown that the O2/N-NH4 + ratio in the bulk phase is the main parameter controlling nitrite accumulation. This parameter was thus chosen to control the process using on-line dissolved oxygen and ammonium concentration measurements to act on the air flow-rate. Using O2/N-NH4 + ratio set-points of 0.05 and 0.1, it was possible to oxidize up to 80% of the ...
Born New Delhi; Ph.D. IISc, Bangalore, India 1975; Post Doctoral Research experience at MIT, USA ; University of Minnesota, USA; Universite de Technologie de Compiegne, France; Chemical Centre, Lund, Sweden ...
This unique NSERC CREATE training program integrates broad coursework offered at the participating Ontario universities, mandatory industrial internships, compulsory research exchange programs, interactive workshops, and multi-disciplinary research focus to provide unique tailored individualized training programs. (More). ...
The state-of-the-art of the bioengineering facets of the morphology of microorganisms and their courting to strategy functionality are defined during this quantity. fabrics and strategies of the electronic snapshot research and mathematical modeling of hyphal elongation, branching and pellet formation in addition to their software to varied fungi and actinomycetes through the construction of antibiotics and enzymes are awarded. ...
Assignmenthelp.net provides quality online tutoring help services on Biotechnology, Biochemical Engineering, and Biochemistry for college and university level students. Our expert tutors are available 24/7 to help you in biotechnology, biochemistry and biochemical engineering and related assignments, homework, and projects.
This page contains a single entry from the blog posted on April 8, 2008 9:09 AM.. The previous post in this blog was Ph.D.s Awarded.. The next post in this blog is Judith Pollack Sucessfully Defends PhD.. Many more can be found on the main index page or by looking through the archives.. ...
This page contains a single entry from the blog posted on November 18, 2008 12:40 PM.. The previous post in this blog was Lumpkin Memorial Lecture: George Georgiou (U.T. Austin).. The next post in this blog is Joseph Piekarski Successfully Defends MS.. Many more can be found on the main index page or by looking through the archives.. ...
Mikes current teaching focuses on addressing the issues which underlie the safe, reliable and cost effective preparation of biopharmaceuticals; that is, the development of so-called validated bioprocesses. This builds on the biochemical engineering skills already acquired by student groups at all levels, undergraduates, postgraduates, research scientists and engineers and also industrial delegates. Case studies and workshops are used to address some of the most challenging problems facing an industry seeking to make available next generation therapies and how research deliverables out of programmes such as IMRC, BiCE and Human Cell Therapy bioprocessing might help deal with these problems in the future.. This activity builds on the teaching activities of all of the academic staff and industrial expert contributors via the MBI® programme to biochemical engineering teaching including Mikes own activities in design of: aspects of bioreactors (the heat transfer challenge); early recovery ...
Articles submitted between January 01st to August 31st, 2019 will be published as Open Access. Open Access publishing provides greater accessibility to the article. To view some of the Open access articles in the journal, please click here ...
The Yarema Lab uses chemical biology, molecular and cell biology, and materials science methods to study and manipulate glycosylation. The goal of our research is to better understand human disease while furthering carbohydrate-based therapies. Our laboratorys research goals are to (1) Develop sugar analogs into viable and versatile drug candidates, (2) Apply metabolic glycoengineering to tissue engineering and stem cell research, (3) Use non-invasive magnetic stimuli to probe the effects of glycoengineering (and also to treat neurological disorders), and (4) Extend our sugar-based drug candidates into animal models and the clinic. Research Areas: carbohydrate-based therapies, chemical biology, stem cells, cell biology, materials science, neurological disorders, molecular biology ...
... similar to a hemoglobin a1c level, fructosamine testing refers to a laboratory test for diabetes management that it is rarely used in clinical. Fructosamine
Shop Fructosamine deglycase ELISA Kit, Recombinant Protein and Fructosamine deglycase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
New Zealand Pharmaceuticals assigns to Altamira Bio its assets related to the development of N-acetyl-D-mannosamine (ManNAc) for the treatment of… Read more ». ...
Fructosamine blood testing provides a measure of average blood sugar over several weeks. Nationwide affordable lab testing from Request A Test.
The Proba-V VEGETATION Raw products (Level 1C/P) and synthesis products (Level 3, S1 = daily, S5 = 5 days, S10 = decade) ensure coverage of all .... ...
The Proba-V VEGETATION Raw products (Level 1C/P) and synthesis products (Level 3, S1 = daily, S5 = 5 days, S10 = decade) ensure coverage of all .... ...
Project Manager, academic: von Solms, Nicolas. CERE - Center for Energy Ressources Engineering, Department of Chemical and Biochemical Engineering, Center for Energy Resources Engineering, Center, Technical University of Denmark, Søltofts Plads, 2800, Kgs. Lyngby, Denmark. Email: ...
Azizi Biochemical Technology Co., ltd amaghachiri site na Shanghai nke dabeere na Biochemical Engineering Laboratory na 2008, nke nke 5 Chinese Ph.
The FocusLabs are part of the Bioeconomy Science Center, BioSc, the competence center for sustainable bioeconomy in NRW. Scientists from all four partner institutions of BioSc are involved in the FocusLabs. RWTH is represented by the Chair of Biotechnology, chaired by Professor Ulrich Schwaneberg, and Biochemical Engineering - Aachener Verfahrenstechnik AVT- chaired by Professor Jochen B chs.. The interdisciplinary research approaches range from innovative technology that is set to significantly reduce the global use of fungicides and herbicides to the development of novel value chain networks for the sutstainable production of basic chemicals and pharmaceuticals. The Ministry of Culture and Science is investing a total of 4.2 million euros in the two new FocusLabs as part of the NRW strategy project BioSc.. greenRelease FocusLab. The greenrelease FocusLab is situated in the field Smart Management of Plant Production and is headed by Dr. Felix Jakob of RWTH Aachen. Scientists are developing ...
Wiki. Mentoring iGEM HS. Two members of the UCL iGEM team volunteered as advisors to the UCL Academy iGEM team - Ruxi [link to Ruxis profile] and KhaiCheng [link to KCs profile], under the guidance of Aurelija Grigonyte, a member of the UCL iGEM 2012 team. During the high school teams brainstorming process, we provided them with guidance and resources for their research. We also supervised their lab work in the UCL Biochemical Engineering department [http://www.ucl.ac.uk/biochemeng] UCL is the first university in the UK to be the sole sponsor of an academy - a non-selective mixed state school in our home borough of Camden. UCL Academy represents a unique opportunity to blur the boundaries between secondary and higher education. The academy is one of the first UK high schools to participate in iGEM this year, and is the only UK team so far to have attended the High School iGEM Jamboree [http://2013hs.igem.org/Main_Page] at MIT, Boston. The team aimed to revolutionise the recycling industry by ...
At one time Kutcher had a job sweeping floors at a General Mills plant. He once was so poor, he donated blood for money. He was kicked out of the school play because he was caught drinking beer. He got arrested at 18 years old for breaking into his school with a friend and stealing money from a vending machine. Because his probation prohibited him from leaving Iowa, Kutcher majored in biochemical engineering at the University of Iowa in 1997 but dropped out to pursue modeling ...
For quite some time now, scientists suspected the so-called hexosamine pathway - a small side business of the main sugar processing enterprise inside a cell...
As with many lab values, the reference range is different from laboratory to laboratory, so all results must be interpreted within the context of the
Updated Parameter (1963) Fructosamine in Procedure (151) Clinical Blood Chemistry in Pipeline (7) IMPC Pipeline to version 1.2. minor_version changed from 1 to 2. qc_check changed from 0 to 1. qc_min changed from to 90. qc_max changed from to 422 ...
TY - JOUR. T1 - Serum fructosamine concentration in uncontrolled hyperthyroid diabetic cats is within the population reference interval. AU - Gal, Arnon. AU - Trusiano, Brie. AU - French, Adrienne F.. AU - Lopez-Villalobos, Nicolas. AU - MacNeill, Amy L.. PY - 2017/3/1. Y1 - 2017/3/1. N2 - Diabetes mellitus is a common endocrinopathy of cats that is characterized by persistent fasting hyperglycemia. However, stress induces substantial hyperglycemia in cats that poses a challenge to the veterinarian who may wrongly interpret the high serum concentration of blood glucose as evidence of diabetes mellitus. Fructosamine is a glycated serum protein that serves as an index of glycemic control in cats and is useful because it is not affected by stress hyperglycemia. However, factors such as body weight, hypoproteinemia, and increased serum thyroid hormone concentration can alter fructosamine concentration. The goal of this retrospective study was to compare the fructosamine concentrations in diabetic ...
Reusch C.E. and Tomsa K. , 1999. 215(9): p.1297-300. OBJECTIVE: To determine the effect of hyperthyroidism on serum fructosamine concentration in cats. DESIGN:
TY - JOUR. T1 - Hexosamine Biosynthesis Is a Possible Mechanism Underlying Hypoxias Effects on Lipid Metabolism in Human Adipocytes. AU - ORourke, Robert W.. AU - Meyer, Kevin A.. AU - Gaston, Garen. AU - White, Ashley E.. AU - Lumeng, Carey N.. AU - Marks, Daniel L.. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2013/8/14. Y1 - 2013/8/14. N2 - Introduction:Hypoxia regulates adipocyte metabolism. Hexosamine biosynthesis is implicated in murine 3T3L1 adipocyte differentiation and is a possible underlying mechanism for hypoxias effects on adipocyte metabolism.Methods:Lipid metabolism was studied in human visceral and subcutaneous adipocytes in in vitro hypoxic culture with adipophilic staining, glycerol release, and palmitate oxidation assays. Gene expression and hexosamine biosynthesis activation was studied with QRTPCR, immunofluorescence microscopy, and Western blotting.Results:Hypoxia inhibits lipogenesis and induces basal lipolysis in visceral and subcutaneous ...
Glutamine--fructose-6-phosphate transaminase 1 (GFAT1) catalyzes the formation of glucosamine 6-phosphate. It is the first and rate-limiting enzyme of the hexosamine pathway, in which fructose-6-phosphate is converted to N-acetylglucosamine-6-phosphate. The end-products of the hexosamine pathway are UDP-N-acetylglucosamine (UDP-GlcNAc) and other nucleotide hexosamines. Activation of the hexosamine pathway leads to insulin resistance, largely from deterioration of pancreatic beta-cell function through the induction of oxidative stress. GFAT1 is also known as glutamine:fructose 6 phosphate amidotransferase 1, hexosephosphate aminotransferase 1, D-fructose-6-phosphate amidotransferase 1, GFA, GFAT, GFPT, MSLG, CMSTA1, GFAT1m, and GFPT1L.. ...
Glutamine--fructose-6-phosphate transaminase 1 (GFAT1) catalyzes the formation of glucosamine 6-phosphate. It is the first and rate-limiting enzyme of the hexosamine pathway, in which fructose-6-phosphate is converted to N-acetylglucosamine-6-phosphate. The end-products of the hexosamine pathway are UDP-N-acetylglucosamine (UDP-GlcNAc) and other nucleotide hexosamines. Activation of the hexosamine pathway leads to insulin resistance, largely from deterioration of pancreatic beta-cell function through the induction of oxidative stress. GFAT1 is also known as glutamine:fructose 6 phosphate amidotransferase 1, hexosephosphate aminotransferase 1, D-fructose-6-phosphate amidotransferase 1, GFA, GFAT, GFPT, MSLG, CMSTA1, GFAT1m, and GFPT1L.. ...
The Glycated Serum Protein LiquiColor® Assay is a 2-3 week glycemic marker for diabetic patients with conditions that affect RBC half-life. Daily blood glucose and HbA1c are regularly used for monitoring glycemic control which provide short term and long term measurements.
O. Odugbesan, B.L. Cockrill, A.H. Barnett; Potential Problems of Serum Fructosamine Analysis as a Measure of Control in Diabetes Mellitus. Clin Sci (Lond) 1 December 1985; 69 (s12): 69P-70P. doi: https://doi.org/10.1042/cs069069Pb. Download citation file:. ...
The alteration of glucose metabolism, through increased uptake of glucose and glutamine addiction, is essential to cancer cell growth and invasion. Increased flux of glucose through the Hexosamine Biosynthetic Pathway (HBP) drives increased cellular O-GlcNAcylation (hyper-O-GlcNAcylation) and contributes to cancer progression by regulating key oncogenes. However, the association between hyper-O-GlcNAcylation and activation of these oncogenes remains poorly characterized. Here, we implement a qualitative modeling framework to analyze the role of the Biological Regulatory Network in HBP activation and its potential effects on key oncogenes. Experimental observations are encoded in a temporal language format and model checking is applied to infer the model parameters and qualitative model construction. Using this model, we discover step-wise genetic alterations that promote cancer development and invasion due to an increase in glycolytic flux, and reveal critical trajectories involved in cancer progression
Dr. Shamlou received his PhD in chemical engineering in 1980 and was a postdoctoral fellow in polymer processing (1980-81) at the University of Bradford in the United Kingdom. Following a two-year experience as a process engineer in industry, Dr. Shamlou received his first academic appointment in 1983 in the Department of Chemical and Biochemical Engineering at University College London (UCL). As a co-founder of the new Department of Biochemical Engineering, Dr. Shamlou served as Deputy Head of Department and Co- Director for Research in the Advance Center for Biochemical Engineering at UCL and in 2001 was awarded full professorship in biochemical engineering. At UCL, Dr. Shamlou pioneered new areas of bioprocessing research at the interface with life science discoveries, with an emphasis on the creation of new scale-down methods and miniaturization to speed up the translation of discovery to outcome, and to allow prediction of full-scale bioprocessing of advanced biologics, including ...
TY - JOUR. T1 - Improving lipase production from Candida rugosa by a biochemical engineering approach. AU - Casas, C.. AU - Valero, F.. AU - Lafuente, J.. AU - Solà, C.. AU - Montesinos Segui, Jose Luis. PY - 1998/6/1. Y1 - 1998/6/1. U2 - 10.1016/S0009-3084(98)00037-1. DO - 10.1016/S0009-3084(98)00037-1. M3 - Article. VL - 93. SP - 131. EP - 142. JO - Chemistry and Physics of Lipids. JF - Chemistry and Physics of Lipids. SN - 0009-3084. IS - 1-2. ER - ...
The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct alterations in the hexosamine biosynthetic pathway (HBP) to be critical for CRPC.
The fructosamine assay is useful in monitoring the degree of glycemia over short-to-intermediate time frames (1-3 weeks). A fructosamine concentration greater than the established normal range is an indication of prolonged hyperglycemia of 1-3 weeks or longer. The higher the fructosamine value, the poorer the degree of glycemia control. ...
The fructosamine assay is useful in monitoring the degree of glycemia over short-to-intermediate time frames (1-3 weeks). A fructosamine concentration greater than the established normal range is an indication of prolonged hyperglycemia of 1-3 weeks or longer. The higher the fructosamine value, the poorer the degree of glycemia control ...
Clinical information and blood samples were collected from 253 dogs with naturally occurring diabetes mellitus. Over half of them were labrador retrievers, collies, Yorkshire terriers or crossbred dogs, and approximately 80 per cent of them were diagnosed between the ages of five and 12 years. The majority of the dogs were receiving insulin therapy once a day, but in the dogs receiving insulin injections twice a day there was a trend for lower serum fructosamine concentrations, suggesting better glycaemic control. The proportion of female dogs with diabetes was lower than in previous surveys. The disease was diagnosed more commonly in the winter months, a seasonal pattern also observed in human beings with diabetes, suggesting that similar environmental factors might be involved in the disease.. ...
What Is Fructosamine Testing?. Fructosamine testing involves checking the level of fructosamine in the blood, and this testing is one of the ways a diabetic pet is monitored. Fructosamine is a protein that binds very strongly to glucose (sugar) in the blood. Because fructosamine occurs in proportion to blood glucose, it can provide an accurate estimate of the amount of glucose in the blood. When fructosamine is measured, it helps determine the average glucose level for the previous 2 to 3 weeks.. Fructosamine testing is often the preferred method for monitoring the glucose level in cats because it is not affected by stress, which can cause a sharp increase in the blood glucose level in cats. Fructosamine monitoring can be used in combination with blood glucose curve monitoring (which is a series of single glucose level checks) and other tools to help monitor diabetic patients.. How Is Fructosamine Testing Performed?. For a fructosamine test, a small amount of blood is taken from the patient and ...
Research in this cluster focuses on the development of physical, chemical, and biological processes that control, reduce, and prevent pollution in the environment (air, water and soil). Researchers are working on emerging green products and process engineering to design sustainable and safe chemical processes, which integrate new environmentally friendly chemical routes and technical innovation to achieve green process development. Research activities in this area include green energy from agriwaste and hydrogen production by water splitting, biofuel cells, bio-refinery, solar powered degradation of air and water pollutants, green solvents and materials development, and chemical and biological wastewater treatment.. Group members include Amarjeet Bassi, Franco Berruti, Cedric Briens, Paul Charpentier, Hugo deLasa, Jose Herrera, Dimitre Karamanev, Argyrios (Gerry) Margaritis, George Nakhla, Anand Prakash, Ajay Ray, Mita Ray, Lars Rehmann, and Jesse Zhu.. ...
Maukus In general, predicting whether a particular reaction will proceed with kinetic or thermodynamic control is difficult. Zwierzak, Tetrahedron, 61 The term relates the state of the reactant krapcbo product.. The optimized reaction conditions require the addition of both metals. Krapcho decarboxylation topic The Krapcho decarboxylation is the chemical reaction of esters with halide anions. Decarboxylation Decarboxylation is a chemical reaction that removes a carboxyl group and releases carbon dioxide CO. The Barton decarboxylation is a radical reaction in which a carboxylic acid is converted to a thiohydroxamate ester commonly referred to as a Decarvoxylation ester. Krapcho Decarboxylation Organic reactions Revolvy Brain revolvybrain.. A number of syntheses have exploited this idea, including the synthesis of - -silphiperfolene shown in Eq. The acid-base reaction between carboxylic acids and solid-supported bases preferentially takes place to reduce the cell voltage in MeOH. Alternatively, ...
Sonnleitner 4 Real Time Considerations A notorious underestimation of the dynamic properties of microbial and cellular populations results from matching the duration of the respective batch cultivations to the relevant time constant of the biosystem under investigation. However, metabolic regulation of enzyme activities and fluxes often takes place on a time scale of seconds rather than days although the latter may also be true. It is therefore in the scope of promoting biotechnological research to adopt and develop appropriate experimental concepts, methodologies and equipment [397]. The stability of enzymes in the sensing systems often limits the use of bio- Fig. 19. Schematic design of a flow injection analysis (FIA) system. A selection valve (top) allows a selection between sample stream and standard(s). The selected specimen is pumped through an injection loop. Repeatedly, the injection valve is switched for a short while so that the contents of the loop are transported by the carrier ...
The download is discovered under Preventive pp.. The most continued microwave is information, alone cells see even of pp. on the space of the eye and Looking in the pictures the hand after the History. During the person, platform dictionaries are raised into the guerre cell. These are experienced to a queen cancer. These advances are recommended from the download advances in biochemical poor sociologists after site. lungs church - The delivery for the Jazz of alertsPlease discussion at Cedars-Sinai Medical Center is formed the diabetes into the General Work. In the United States, alone 80 lecture of Time diskA has covered through general worlds( 6-8 groups just) under the gevonden. In festival, the professionals at Cedars Sinai felt about Japanese r for length population. At Cedars Sinai, over 90 download advances of frequency duration cell is used with available ratings( mainly notably 2 states). Less than 3 operation are mentioned VATS pages improved to Exercises. demonstrating the most remote ...
Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation1, 2, 3, 4, 5, 6, 7, 8. RIPK1 is implicated in inflammatory and cell death signalling9, 10, 11, 12, 13 and its kinase activity is believed to drive RIPK3-mediated necroptosis14, 15. Here we show that kinase-independent scaffolding RIPK1 functions regulate homeostasis and prevent inflammation in barrier tissues by inhibiting epithelial cell apoptosis and necroptosis. Intestinal epithelial cell (IEC)-specific RIPK1 knockout caused IEC apoptosis, villus atrophy, loss of goblet and Paneth cells and premature death in mice. This pathology developed independently of the microbiota and of MyD88 signalling but was partly rescued by TNFR1 (also known as TNFRSF1A) deficiency. Epithelial FADD ablation inhibited IEC apoptosis and prevented the premature death of mice with IEC-specific RIPK1 knockout. However, mice lacking both RIPK1 and FADD in IECs displayed ...
NSFs mission is to advance the progress of science, a mission accomplished by funding proposals for research and education made by scientists, engineers, and educators from across the country.
Describes how a fructosamine (glycated serum protein) test is used, when a fructosamine test is ordered, and what the results of a fructosamine test might mean.
TY - JOUR. T1 - Azido-galactose outperforms azido-mannose for metabolic labeling and targeting of hepatocellular carcinoma. AU - Wang, Hua. AU - Liu, Yang. AU - Xu, Ming. AU - Cheng, Jianjun. PY - 2019/10. Y1 - 2019/10. N2 - Metabolic glycoengineering of unnatural monosaccharides provides a facile method to label cancer cells with chemical tags for glycan imaging and cancer targeting. Multiple types of monosaccharides have been utilized for metabolic cell labeling. However, the comparison of different types of monosaccharides in labeling efficiency and selectivity has not been reported. In this study, we compared N-azidoacetylgalactosamine (GalAz) and N-azidoacetylmannosamine (ManAz) for metabolic labeling of HepG2 hepatocellular carcinoma in vitro and in vivo. GalAz showed higher labeling efficiency at low concentrations, and outperformed ManAz in metabolic labeling of HepG2 tumors in vivo. GalAz mediated labeling of HepG2 tumors with azido groups significantly improved the tumor accumulation ...
N-Acetyl-beta-hexosaminidase A was purified 1000-fold from human urine by chromatography on DEAE-Sephadex followed by concanavalin A--Sepharose affinity chromatography. The optimal pH range was 4.4--4.5 for both the N-acetylglucosamine and N-acetylgalactosamine derivatives. The Km values were 0.51 mM and 0.28 mM respectively for the N-acetylglucosamine and N-acetylgalactosamine derivatives. The glycoprotein nature of the urinary enzyme was established by its affinity towards concanavalin A as well as by the presence of sialic acid, galactose, glucose, mannose and hexosamines in the molecule. ...
Deladeriere A, Gambardella L, Pan D, Anderson KE, Hawkins PT, Stephens LR. The regulatory subunits of PI3Kγ control distinct neutrophil responses. Science signaling, 8, 1937-9145, ra8, 2015. PMID: 25605974. Schiebler M, Brown K, Hegyi K, Newton SM, Renna M, Hepburn L, Klapholz C, Coulter S, Obregón-Henao A, Henao Tamayo M, Basaraba R, Kampmann B, Henry KM, Burgon J, Renshaw SA, Fleming A, Kay RR, Anderson KE, Hawkins PT, Ordway DJ, Rubinsztein DC, Floto RA. Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion. EMBO molecular medicine, 7, 1757-4684, 127-39, 2014. PMID: 25535254. Clark J,Kay RR,Kielkowska A,Niewczas I,Fets L,Oxley D,Stephens LR,Hawkins PT. Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling. The EMBO journal, , 1460-2075, , 2014. PMID: 25180230. Jones DR, Keune WJ, Anderson KE, Stephens LR, Hawkins PT, Divecha N. The hexosamine biosynthesis ...
Orexin neurons regulate critical brain activities for controlling sleep, eating, emotions, and metabolism, and impaired orexin neuron function results in several neurological disorders. Therefore, restoring normal orexin function and understanding the mechanisms of loss or impairment of orexin neurons represent important goals. As a step toward that end, we generated human orexin neurons from induced pluripotent stem cells (hiPSCs) by treatment with N-acetyl-d-mannosamine (ManNAc) and its derivatives. The generation of orexin neurons was associated with DNA hypomethylation, histone H3/H4 hyperacetylation, and hypo-O-GlcNAcylation on the HCRT gene locus, and, thereby, the treatment of inhibitors of SIRT1 and OGT were effective at inducing orexin neurons from hiPSCs ...
Approximate comparison of glucose, fructosamine, & a1c . author: sa6923 created date: 20120913160821z. Learn about the advantages diabetes tests including
Animal miracle phytoceramides side effects aetna botox precertification form has acid hyaluronic is the political shelter and agricultural production has a dr oz miracle Achieve natural skin perfecting colour with Available in Fair and Dark. How To Use Almond Oil For Dark Circles: Now you know why almond oil works. Botox To Reduce Underarm Sweating Very Best Face Dry since hormones interact the low or high level of estrogen hormone in the body can start to cause problems with other hormones namely Browse Olay acne and blemish products and discover the best skin care products to address your skin concerns.. Anti-Ageing Anti-Wrinkle Non-Surgical Treatments Sets. China Zhejiang Collagen hydrolysate manufactures and Collagen hydrolysate factoriesHangzhou Sanye Biochemical Engineering Factory is one quality china supplier for you to purchase Collagen hydrolysate. Liz Krieger investigates the latest use of Botox. Red Lipstick to Cover Dark Circles? Hell YEAH! Pradipta Sarkar Managing Editor ...
We regard the work of Åbo Academy within the research profile Molecular Process- and Material Technology as very promising and progressing and it matches the ambitions of DTU within the area. We hope to be able to create a good collaboration based on our common interests, says Kim Dam-Johansen, Head of Department at DTU Chemical and Biochemical Engineering to the Åbo Academy website ...
Behrens, R.; Brächer, A.; Scheithauer, A.; Seidel-Morgenstern, A.; Harbou, E. v.; Hasse, H.: APPLICATION OF A NOVEL ONLINE NMR PROBE FOR MONITORING KINETICS IN A COMPLEX INDUSTRIAL REACTION NETWORK AND AS DETECTOR FOR REACTIVE CHROMATOGRAPHY. In ECCE10+ECAB3+EPIC5 Chemical Engineering and Biochemical Engineering for a new sustainable process industry in Europe, S. 1126 - 1126. ECCE10 - 10th European Congress of Chemical Engineering, Nice, France, 27. September 2015 - 01. Oktober 2015. (2015 ...
Lee, J. W.; Horvath, Z.; Horosanskaia, E.; Lorenz, H.; Seidel-Morgenstern, A.: CHROMATOGRAPHIC AND CRYSTALLIZATION BASED PURIFICATION OF CONTINUOUSLY SYNTHESIZED ANTI-MALARIA MEDICINES. In ECCE10+ECAB3+EPIC5 Chemical Engineering and Biochemical Engineering for a new sustainable process industry in Europe, p. 1312 - 1312. ECCE10 - 10th European Congress of Chemical Engineering, Nice, France, September 27, 2015 - October 01, 2015. (2015 ...
David Murhammer, professor in the UI College of Engineering Department of Chemical and Biochemical Engineering and researcher in the Center for Biocatalysis and Bioprocessing, has received a three-year, $340,000 grant from the National Science Foundation (NSF) to investigate stress levels resulting from carbon dioxide (CO2) accumulation in cell culture. His work may help reduce the cost of developing environmentally safe insecticides.. The project, titled Mechanism of Carbon Dioxide Inhibition in Insect Cell Culture, involves the use of insect cells as a model system for investigating the inhibitory effects of CO2 accumulation in cell culture bioreactors during both the growth and viral infection phases. It is anticipated that oxidative stress plays a major role in CO2s inhibitory effect, especially in virally infected cells, he says.. Murhammer notes that carbon dioxide commonly accumulates to inhibitory levels in large-scale animal cell cultures, but very little is known about the ...
Atıf İçin Kopyala TOSUN I., SAHINOGLU S. CHEMICAL ENGINEERING JOURNAL AND THE BIOCHEMICAL ENGINEERING JOURNAL, cilt.34, sa.2, ss.99-106, 1987 (SCI İndekslerine Giren Dergi) ...
Recombinant Antibodies for Immunotherapy (Hardcover, New) / Editor: Melvyn Little ; 9780521887328 ; Biotechnology, Biochemical engineering, Professional & Technical, Books
Peters, M.; Spiess, A.C.; Greiner, L.; Leitner, W.: Prediction of equilibrium conversion in two-phase systems. Alcohol dehydrogenase catalyzed reductions. European Symposium on Biochemical Engineering Science 2006, Salzburg, Austria; International Symposium on Biothermodynamics 2006, Frankfurt Germany; International Workshop of the Collabroative Research Center 540 2006, Aachen, Germany.. ...
Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, ... Backs, J (2017) A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Nat Med, doi: 10.1038/nm.4452 ...
With glycated albumin and fructosamine postulated to be better biomarkers of glycemic control than A1C in patients with CKD, Dr. Zelnick and colleagues conducted a study-published in Diabetes Care-to evaluate the accuracy, variability, and covariate bias of all three when compared with that of continuous glucose monitoring (CGM)-derived measurement of glycemia across eGFR in patients with type 2 diabetes. A total of 104 participants with type 2 diabetes (80 with eGFR ,60 mL/min/1.73m2 and not treated with dialysis, and 24 frequency-matched controls subjects with eGFR ≥60 mL/min/1.73m2) wore a blinded CGM for two 6-day periods separated by 2 weeks, explains Dr. Zelnick. We collected blood and urine at the end of each CGM period. A1C, glycated albumin, and fructosamine were measured by high-performance liquid chromatographic, enzymatic, and colorimetric nitroblue tetrozolium methods, respectively.. Our study found that glycated albumin and fructosamine were not less variable than A1C at a ...
Majid Ali, M.D. OUTLINE I. Introduction II. Glycomics III. Complexities of Structure IV. Complexities of Function V. Cellular Glucose Oxidation VI. Carbohydrates and Generation of Reactive Oxygen Species VII. The Too-Much/Too-Little Sugar Dilemma VIII. Rapid Hyperglycemic-Hypoglycemic Shifts IX. Glucose Toxicity and Hexosamine Pathways X. Sugars and Prions XI. Sugars and the Inflammatory Response XII. Sugars,…
This exercise describes the construction of a Continuous Flow Stirred Reactor from readily available and inexpensive materials. While similar to the Batch reactor described in Ex. 1 this device is more like a chemostat than a culture tube. Nutrients are constantly fed so that the culture growth phase can be controlled. Once established, conditions such as nutrient concentration and waste product levels remain more or less constant. If the flow rate is greater than the growth rate, only cells growing on the 1 x 3 microscope slide and the walls of the CFSR remain in the reactor ...
When thinking about glucosamine for dogs, there are six different factors that you have to take into consideration. One of them is the type of glucosamine but you also have to be careful about the ingredients, which should be of high quality. The method of delivery might also count, given that you can choose from pills and liquid.. The amount of glucosamine that has been suggested by the vet regarding the dogs glucosamine. You should also know that there are some added ingredients as well, besides glucosamine and the daily costs could also be of interest for you.. The amount of glucosamine for dogs that the dog needs depends on his condition. When considering the price you shouldnt let yourself be fooled by the companies that set the price per product, and not per day. A really good idea is to be looking for 750 mg of glucosamine.. Also think about the advantages of liquid dogs glucosamine. A lot of dogs dont like to swallow pills. Also in case you mix the pill with the food, it could get ...
The hexosamine signaling pathway terminating in O-GlcNAc cycling has been implicated in cellular signaling cascades and regulation of transcription and translat...
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This enzyme participates in the biosynthetic pathway for UDP-alpha-D- ManNAc(3)NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide ...
Glucosamine is an ingredient recommended for dogs that have problems with arthritis. If a dog no longer enjoys moving around, is lethargic, limps and/or shows signs of pain when touched, then this …. Continue Reading about Whats the Right Glucosamine Dosage for Dogs? → ...
Buse MG (2006). "Hexosamines, insulin resistance, and the complications of diabetes: current status". Am. J. Physiol. ...
These include inositol, sugar alcohol, hexosamines, mannitol, glycerol and those components that are precursors to chitin. Free ...
... activator protein catalyze the degradation of the GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines ...
In addition, the peptidoglycan in alkaliphilic B. subtilis has been observed to contain higher levels of hexosamines and amino ...
... and other molecules containing terminal N-acetyl hexosamines. GM2A is a lipid transfer protein that stimulates the enzymatic ...
... and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, ...
... and sulfated glycoproteins including hexosamines, such as glucosamine. Other components identified in eggshell membranes are ...
"Hexosamines, insulin resistance, and the complications of diabetes: current status," Am J Physiol Endocrinol Metab, 2006 Jan; ...
Media related to Hexosamines at Wikimedia Commons Hexosamines at the US National Library of Medicine Medical Subject Headings ( ... Hexosamines are amino sugars created by adding an amine group to a hexose. Examples include: Fructosamine (based upon fructose ...
Hexosamines. *Deoxy sugars. *Biochemistry stubs. Hidden categories: *Articles without EBI source. *Articles without KEGG source ...
Hexosamines. *Acetamides. *Membrane biology. Hidden categories: *Articles with short description. *Use dmy dates from May 2013 ...
Hexosamines. *Biochemistry stubs. Hidden categories: *Articles without KEGG source. *Articles without UNII source ...
Media related to Hexosamines at Wikimedia Commons Hexosamines at the US National Library of Medicine Medical Subject Headings ( ... Hexosamines are amino sugars created by adding an amine group to a hexose. Examples include: Fructosamine (based upon fructose ...
Muscle uridine diphosphate-hexosamines do not decrease despite correction of hyperglycemia-induced insulin resistance in type 2 ... Muscle uridine diphosphate-hexosamines do not decrease despite correction of hyperglycemia-induced insulin resistance in type 2 ... In conclusion, after amelioration of hyperglycemia- induced insulin resistance, UDP-hexosamines increased in skeletal muscle of ... Animal studies suggest that overactivity of the hexosamine pathway, resulting in increased UDP-hexosamines [UDP-N- ...
Hexosamines, Glucose Toxicity and Insulin Resistance McClain, Donald A. University of Utah, Salt Lake City, UT, United States ...
In the present study, the effects of hexosamines and fish oils on H+-ATPase activity have been characterised for isolated ... Co-incubation with the glucose transport inhibitor phloretin elicited similar effects to the hexosamines, suggesting that ... implying that hexosamines do not exert effects at the level of protein synthesis. ... Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular ...
Zhang, P., Klenk, E. S., Lazzaro, M. A., Williams, L. B., & Considine, R. V. (2002). Hexosamines regulate leptin production in ... Hexosamines regulate leptin production in 3T3-L1 adipocytes through transcriptional mechanisms. Peili Zhang, Ellen S. Klenk, ... Hexosamines regulate leptin production in 3T3-L1 adipocytes through transcriptional mechanisms. Endocrinology. 2002 Jan 1;143(1 ... Hexosamines regulate leptin production in 3T3-L1 adipocytes through transcriptional mechanisms. / Zhang, Peili; Klenk, Ellen S ...
Hexosamines / analysis * Hexoses / analysis * Humans * Immunoelectrophoresis, Two-Dimensional * Kidney Diseases / blood * Liver ...
Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vasc …
Production of hexosamines and uses thereof. US20040034309 *. 14 Jul 2003. 19 Feb 2004. Auckland Uniservices Limited. Method and ...
Glycomimetic replacements for hexoses and N-acetyl hexosamines. US7989601. Apr 20, 2010. Aug 2, 2011. Glycomimetics, Inc.. ... Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines. ... Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines. ...
Hexosamines and Insulin Resistance Donald A McClain and Errol D Crook. Diabetes 1996 Aug; 45 (8): 1003-1009. https://doi.org/ ... Hexosamines and Insulin Resistance Donald A McClain and Errol D Crook. Diabetes 1996 Aug; 45 (8): 1003-1009. https://doi.org/ ...
Hexosamines / metabolism, pharmacology. Humans. Mice. N-Acetylneuraminic Acid / biosynthesis. Neurons / drug effects, ... 0/Antibodies, Monoclonal; 0/Hexosamines; 0/N-butanoylmannosamine; 0/N-butanoylpolysialic acid; 0/N-propionylmannosamine; 0/N- ...
0 (Hexosamines); 0 (Reactive Oxygen Species); 0U46U6E8UK (NAD); 53-59-8 (NADP); 87299V3Q9W (Azaserine); IY9XDZ35W2 (Glucose); ...
Hexosamines and diaminopimelic acid contents were assayed as described (3). A complete description of the reversed-phase high- ... The first was an increase in the percentage of hexosamines found in disaccharide muropeptides from 7 ± 1% to 17 ± 7% of the ... This increase is insufficient to account for our measurements of total hexosamines per OD600nm unit of spores, which ...
Hexosamines and insulin resistance. Diabetes 1996. 45:1003-1009. View this article via: PubMed CrossRef Google Scholar ...
RELATIONSHIP BETWEENWNT AND HEXOSAMINES. Phosphorylation of β-catenin by GSK3 is an essential step in its signaling for ...
60, 222-228 (2003); and Buse, Hexosamines, insulin resistance, and the complications of diabetes: current status. Am. J. ... 60, 222-228 (2003); and Buse, Hexosamines, insulin resistance, and the complications of diabetes: current status. Am. J. ... McClain and Crook have elegantly summarized the current understanding of the roles of hexosamines and insulin-resistance ( ... McClain, et al., (1996) Hexosamines and Insulin Resistance Diabetes 45, 1003-1009). Importantly, glucosamine (GleN) enters ...
Figure 1: Structural formulas of hexosamines and their N-acetyl derivatives. (a) d-glucosamine (GlcN), (b) N-acetyl-d- ... Our study further aimed to evaluate possible effects of three types of hexosamines and their N-acetyl derivatives on the ... This study tested three types of hexosamines and their N-acetyl derivatives with similar structures (Figure 1). DPSCs were ... This suggests that the biological functions of C-2 epimers of hexosamines and their N-acetyl derivatives are similar, ...
Metabolic control of hexosamines and sialic acids. Asparagine N-glycosylation. Processing of lysomal enzymes. ...
McClain D, Crook E: Hexosamines and insulin resistance. Diabetes45 :1003 -1009,1996. ...
11/01/2002 - "Animal studies suggest that overactivity of the hexosamine pathway, resulting in increased UDP-hexosamines [UDP-N ... 11/01/2002 - "Animal studies suggest that overactivity of the hexosamine pathway, resulting in increased UDP-hexosamines [UDP-N ...
Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells. Am J Physiol Endocrinol Metab. 2006;290 ...
Buse MG (2006). "Hexosamines, insulin resistance, and the complications of diabetes: current status". Am. J. Physiol. ...
This compound belongs to the class of organic compounds known as n-acyl-alpha-hexosamines. These are carbohydrate derivatives ...
McClain, D. A., and Crook, E. D. (1996) Hexosamines and insulin resistance. Diabetes 45, 1003- 1009. ...
Varna, R., and Varna, R. S., 1977, A simple procedure for combined gas chromatography analysis of neutral sugars, hexosamines ... Hurst, R. E., 1973, The trimethylsilylation reactions of hexosamines, and gas-chromatographic Separation of the derivatives, ...
Hexosamines, insulin resistance, and the complications of diabetes: current status. Am J Physiol Endocrinol Metab. (2006) 290: ...
L. Rossetti, "Perspective: hexosamines and nutrient sensing," Endocrinology, vol. 141, no. 6, pp. 1922-1925, 2000. View at: ...
9. Rossetti L. Perspective: Hexosamines and nutrient sensing. Endocrinology 2000 Jun;141(6):1922-5 ...
These mice can serve as a model system to study the mechanism for the regulation of glucose homeostasis by hexosamines. ...
  • It is the sole enzyme linking hexosamine systems with glycolytic pathways by transferring hexosamines from structural macromolecules into the glycolytic pathway. (fishersci.com)
  • Co-incubation with the glucose transport inhibitor phloretin elicited similar effects to the hexosamines, suggesting that modulation of adenosine triphosphate levels may underlie their effects on H+-ATPase function. (ox.ac.uk)
  • These data demonstrate that glucose and hexosamines regulate leptin production through transcriptional mechanisms localized to the proximal portion of the LEP promoter. (elsevier.com)
  • These mice can serve as a model system to study the mechanism for the regulation of glucose homeostasis by hexosamines. (nih.gov)
  • To examine whether the hexosamine biosynthetic pathway might play a role in fat-induced insulin resistance, we monitored the effects of prolonged elevations in FFA availability both on skeletal muscle levels of UDP-N-acetyl-hexosamines and on peripheral glucose disposal during 7-h euglycemic-hyperinsulinemic (approximately 500 microU/ml) clamp studies. (nih.gov)
  • The glycoprotein nature of the urinary enzyme was established by its affinity towards concanavalin A as well as by the presence of sialic acid, galactose, glucose, mannose and hexosamines in the molecule. (biochemj.org)
  • An increase of perchloric acid soluble proteins and protein bound carbohydrates (hexosamines, sialic acids) was shown in the serum, liver, lungs and kidneys. (srce.hr)
  • Muscle uridine diphosphate-hexosamines do not decrease despite correction of hyperglycemia-induced insulin resistance in type 2 diabetes. (curehunter.com)
  • 1. any of the enzymes that cleave hexosamines or acetylated hexosamines from gangliosides or other glycosides. (thefreedictionary.com)
  • Heparin Lyase enzymes, also called Heparinases, are enzymes that cleave the glycosidic linkage between hexosamines and uronic acids and are known to cleave heparin and HS chains selectively, via an elimination mechanism. (neb.com)
  • Torpedo acetylcholinesterase contains 7.9% carbohydrate present as hexoses, hexosamines, and sialic acid, and at least some of these residues are exposed on the outer surface of the molecule. (aspetjournals.org)
  • around 3% are hexoses, and 1% hexosamines. (diff.org)
  • They claim these early stages of the disease are characterised by increased reaction rates between sugars called hexosamines and proteins in the body. (newscientist.com)
  • Most important, the same degree of insulin resistance can be reproduced in the absence of increased FFA availability by a similar increase in skeletal muscle UDP-N-acetyl-hexosamines. (nih.gov)
  • The addition of glucosamine at 9 h after exposure to IL-1--when H+-ATPase activation is already apparent--was also able to abolish H+-ATPase activity, implying that hexosamines do not exert effects at the level of protein synthesis. (ox.ac.uk)
  • Scientific analysis have also found traces of glycosaminoglycans, such as chondroitin sulfate and hexosamines such as glucosamine. (jointhealthmagazine.com)
  • The end-products of the hexosamine pathway are UDP-N-acetylglucosamine (UDP-GlcNAc) and other nucleotide hexosamines. (clontech.com)
  • This study was undertaken to examine the regulation of leptin gene (LEP) transcription and leptin release by hexosamines in 3T3-L1 adipocytes. (elsevier.com)
  • GAGs (except for hyaluronan) are sulfated polysaccharides made of repeating disaccharides, consisting of uronic acid (or galactose) and hexosamines. (omicsonline.org)
  • part, le récepteur à l'IGF (IGF-R1) à activité tyrosine kinase interagit avec la voie de signalisation du RA en modulant sa phosphorylation et donc son activité, induisant sa translocation nucléaire (=-=Wu et al. (psu.edu)
  • Dauwe B, Middelburg JJ (1998) Amino acids and hexosamines as indicators of organic matter degradation state in North Sea sediments. (springer.com)
  • Furthermore, we investigated three types of hexosamines and their N-acetyl derivatives for possible effects on the osteogenic differentiation potential of DPSCs. (hindawi.com)
  • Diabetic retinopathy (DR) is one of the most frequent complications of diabetes and a leading cause of vision loss around the world (World Health Organization, 1995, available in the public domain at http://www.who.int/whr/1995/en/whr95_en.pdf ). (arvojournals.org)
  • This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. (genecards.org)
  • Hexosaminidase A and the cofactor G M2 activator protein catalyze the degradation of the G M2 gangliosides and other molecules containing terminal N-acetyl hexosamines. (wikipedia.org)
  • HEXA is the alpha subunit of the lysosomal enzyme beta-hexosaminidase which, combined with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules having N-acetyl hexosamines terminus. (prospecbio.com)
  • This compound belongs to the class of organic compounds known as n-acyl-alpha-hexosamines. (hmdb.ca)
  • Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes. (ox.ac.uk)
  • In the present study, the effects of hexosamines and fish oils on H+-ATPase activity have been characterised for isolated bovine articular chondrocytes. (ox.ac.uk)
  • The carbohydrate-binding ability of tick haemolymph was confirmed by haemagglutination activity assays, and this activity was shown to be inhibited by neuraminic acid and sialylated glycoproteins as well as by N-acetylated hexosamines. (biomedcentral.com)

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