Chemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Heterocyclic CompoundsHeterocyclic Compounds, Bridged-RingNitrogen CompoundsCyclizationHeterocyclic Compounds, 2-RingPalladiumHeterocyclic Compounds with 4 or More RingsHeterocyclic Compounds, 3-RingMolecular StructureHeterocyclic Compounds, 1-RingMagnetic Resonance Spectroscopy
Heterocyclic Compounds
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
Heterocyclic Compounds, Bridged-Ring
A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
Nitrogen Compounds
Inorganic compounds that contain nitrogen as an integral part of the molecule.
Cyclization
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Heterocyclic Compounds, 2-Ring
A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
Palladium
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
Heterocyclic Compounds with 4 or More Rings
A class of organic compounds containing four or more ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
Heterocyclic Compounds, 3-Ring
A class of organic compounds containing three ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic
Molecular Structure
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Heterocyclic Compounds, 1-Ring
A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
Magnetic Resonance Spectroscopy
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

Comparison of ultrasmall particles of iron oxide (USPIO)-enhanced T2-weighted, conventional T2-weighted, and gadolinium-enhanced T1-weighted MR images in rats with experimental autoimmune encephalomyelitis. (1/1106)

BACKGROUND AND PURPOSE: Ultrasmall particles of iron oxide (USPIO) constitute a contrast agent that accumulates in cells from the mononuclear phagocytic system. In the CNS they may accumulate in phagocytic cells such as macrophages. The goal of this study was to compare USPIO-enhanced MR images with conventional T2-weighted images and gadolinium-enhanced T1-weighted images in a model of experimental autoimmune encephalomyelitis (EAE). METHODS: Nine rats with EAE and four control rats were imaged at 4.7 T and 1.5 T with conventional T1- and T2-weighted sequences, gadolinium-enhanced T1-weighted sequences, and T2-weighted sequences obtained 24 hours after intravenous injection of a USPIO contrast agent, AMI-227. Histologic examination was performed with hematoxylin-eosin stain, Perls' stain for iron, and ED1 immunohistochemistry for macrophages. RESULTS: USPIO-enhanced images showed a high sensitivity (8/9) for detecting EAE lesions, whereas poor sensitivity was obtained with T2-weighted images (1/9) and gadolinium-enhanced T1-weighted images (0/9). All the MR findings in the control rats were negative. Histologic examination revealed the presence of macrophages at the site where abnormalities were seen on USPIO-enhanced images. CONCLUSION: The high sensitivity of USPIO for macrophage activity relative to other imaging techniques is explained by the histologic findings of numerous perivascular cell infiltrates, including macrophages, in EAE. This work supports the possibility of intracellular USPIO transport to the CNS by monocytes/macrophages, which may have future implications for imaging of human inflammatory diseases.  (+info)

67Cu-versus 131I-labeled Lym-1 antibody: comparative pharmacokinetics and dosimetry in patients with non-Hodgkin's lymphoma. (2/1106)

Antilymphoma mouse monoclonal antibody (MoAb) Lym-1, labeled with 67Cu or 131I, has demonstrated promising results in radioimmunotherapy (RIT) for lymphoma. Although 131I has played a central role in RIT thus far, some properties of 67Cu are preferable. A subset of our patients received both 67Cu- and 131I-labeled Lym-1, allowing a comparative evaluation of the two radiopharmaceuticals administered to a matched population of patients. Four patients with B-lymphocytic non-Hodgkin's lymphoma that had progressed despite standard therapy entered trials of 67Cu- and 131I-labeled Lym-1, which were injected 3-26 days apart. Lym-1 was conjugated to 6-[p-(bromoacetamido)benzyl]-1,4,7,11-tetraazacyclotetradecane-N,N ',N",N'"-tetraacetic acid (BAT) via 2-iminothiolane (2IT) and radiolabeled with 67Cu to prepare 67Cu-2IT-BAT-Lym-1; 131I-Lym-1 was preparred by the chloramine-T reaction. Planar imaging was used to quantitate 67Cu-2IT-BAT-Lym-1 or 131I-Lym-1 in organs and tumors daily for 3 days or longer. 67Cu-2IT-BAT-Lym-1 exhibited higher peak concentration in 92% (12 of 13) of tumors and a longer biological half-time in every tumor than 131I-Lym-1. The mean tumor concentration (%ID/g) of 67Cu-2IT-BAT-Lym-1 was 1.7, 2.2, and 2.8 times that of 131I-Lym-1 at 0, 24, and 48 h after injection, respectively. The mean biological half-times of 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 in tumor were 8.8 and 2.3 days, respectively. Consequently, the mean tumor radiation dose delivered by 67Cu-2IT-BAT-Lym-1 was twice that of 131I-Lym-1, 2.8 (range 0.8-6.7), and 1.4 (range 0.4-35) Gy/GBq, respectively. 67Cu-2IT-BAT-Lym-1 delivered a lower marrow radiation dose than 131I-Lym-1; hence, the tumor:marrow therapeutic indices were 29 and 9.7, respectively. Radiation doses from 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 to normal tissues were similar except for liver, which received a higher dose from 67Cu-2IT-BAT-Lym-1. Images obtained with 67Cu-2IT-BAT-Lym-1 were superior. Radiation dosimetry data for 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 agreed with corresponding data from the larger populations of patients from which the matched population for the current study was drawn. In conclusion, 67Cu-2IT-BAT-Lym-1 given to non-Hodgkin's lymphoma patients in close temporal proximity to 131I-Lym-1 exhibited greater uptake and longer retention in tumor, resulting in higher radiation dose and therapeutic index than 131I-Lym-1. These as well as other factors suggest that 67Cu-2IT-BAT-Lym-1 may be superior to 131I-Lym-1 for RIT.  (+info)

Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice. (3/1106)

RD3-0028, a benzodithiin compound, has antiviral activity against respiratory syncytial virus (RSV) in cell culture. We used a mouse model of RSV infection to determine the in vivo effect of RD3-0028. Cyclophosphamide (CYP)-treated, immunosuppressed mice were inoculated intranasally. The lungs of the mice were removed on day 4. The virus titers of the lungs of RD3-0028-treated mice were compared to the virus titers of the lungs of virus-inoculated, untreated control mice. In an effort to increase the therapeutic effectiveness of this compound, RD3-0028 was administered by aerosol to RSV-infected mice by using a head-exposure system. Aerosols generated from reservoirs containing RD3-0028 (7 mg/ml) administered for 2 h twice daily for 3 days significantly reduced the pulmonary titer of RSV-infected mice. It is clear that the minimal effective dose of RD3-0028 for RSV-infected mice is significantly less than that of ribavirin, the only compound currently available for use against RSV disease. Furthermore, the RD3-0028 aerosol administration appeared to protect the lungs of infected, CYP-treated mice against tissue damage, as evidenced by the preservation of the lung architecture and a reduction in pulmonary inflammatory infiltrates. RD3-0028 aerosol was not toxic for mice at the therapeutic dose. The present study demonstrates the effectiveness of aerosol administration of RD3-0028 for RSV-infected mice.  (+info)

Cancer chemopreventive mechanisms of tea against heterocyclic amine mutagens from cooked meat. (4/1106)

Cooking meat and fish under normal conditions produces heterocyclic amine mutagens, several of which have been shown to induce colon tumors in experimental animals. In our search for natural dietary components that might protect against these mutagens, it was found that green tea and black tea inhibit the formation of heterocyclic amine-induced colonic aberrant crypt foci (ACF) in the rat. Since ACF are considered to be putative preneoplastic lesions, we examined the inhibitory mechanisms of tea against the heterocyclic amines. In the initial studies using the Salmonella mutagenicity assay, green tea and black tea inhibited according to the concentration of tea leaves during brewing and the time of brewing; a 2-3-min brew of 5% green tea (w/v) was sufficient for >90% antimutagenic activity. N-hydroxylated heterocyclic amines, which are direct-acting mutagens in Salmonella, were inhibited by complete tea beverage and by individual components of tea, such as epigallocatechin-3-gallate (EGCG). Inhibition did not involve enhanced mutagen degradation, and EGCG and other catechins complexed only weakly with the mutagens, suggesting electrophile scavenging as an alternative mechanism. Enzymes that contribute to the metabolic activation of heterocyclic amines, namely microsomal NADPH-cytochrome P450 reductase and N, O-acetyltransferase, were inhibited by tea in vitro. Studies in vivo established that tea also induces cytochromes P450 and Phase II enzymes in a manner consistent with the rapid metabolism and excretion of heterocyclic amines. Collectively, the results indicate that tea possesses anticarcinogenic activity in the colon, and this most likely involves multiple inhibitory mechanisms.  (+info)

The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA. (5/1106)

In a screen for mutants that display synthetic lethal interaction with hpr1Delta, a hyperrecombination mutant of Saccharomyces cerevisiae, we have isolated a novel cold-sensitive allele of the acetyl coenzyme A (CoA) carboxylase gene, acc1(cs), encoding the rate-limiting enzyme of fatty acid synthesis. The synthetic lethal phenotype of the acc1(cs) hpr1Delta double mutant was only partially complemented by exogenous fatty acids. hpr1Delta was also synthetically lethal with a previously isolated, temperature-sensitive allele of ACC1, mtr7 (mRNA transport), indicating that the lethality of the acc1(cs) hpr1Delta double mutant was not allele specific. The basis for the interaction between conditional acc1 alleles and hpr1Delta was investigated in more detail. In the hpr1Delta mutant background, acetyl-CoA carboxylase enzyme activity was reduced about 15-fold and steady-state levels of biotinylated Acc1p and ACC1 mRNA were reduced 2-fold. The reduced Acc1p activity in hpr1Delta cells, however, did not result in an altered lipid or fatty acid composition of the mutant membranes but rendered cells hypersensitive to soraphen A, an inhibitor of Acc1p. Similar to mtr7, hpr1Delta and acc1(cs) mutant cells displayed a defect in nuclear export of polyadenylated RNA. Oversized transcripts were detected in hpr1Delta, and rRNA processing was disturbed, but pre-mRNA splicing appeared wild type. Surprisingly, the transport defect of hpr1Delta and acc1(cs) mutant cells was accompanied by an altered ring-shaped structure of the nucleolus. These observations suggest that the basis for the synthetic lethal interaction between hpr1Delta and acc1 may lie in a functional overlap of the two mutations in nuclear poly(A)+ RNA production and export that results in an altered structure of the nucleolus.  (+info)

Diverse oxygenations catalyzed by carbazole 1,9a-dioxygenase from Pseudomonas sp. Strain CA10. (6/1106)

Carbazole 1,9a-dioxygenase (CARDO) from Pseudomonas sp. strain CA10 is a multicomponent enzyme that catalyzes the angular dioxygenation of carbazole, dibenzofuran, and dibenzo-p-dioxin. It was revealed by gas chromatography-mass spectrometry and 1H and 13C nuclear magnetic resonance analyses that xanthene and phenoxathiin were converted to 2,2',3-trihydroxydiphenylmethane and 2,2',3-trihydroxydiphenyl sulfide, respectively. Thus, for xanthene and phenoxathiin, angular dioxygenation by CARDO occurred at the angular position adjacent to the oxygen atom to yield hetero ring-cleaved compounds. In addition to the angular dioxygenation, CARDO catalyzed the cis dihydroxylation of polycyclic aromatic hydrocarbons and biphenyl. Naphthalene and biphenyl were converted by CARDO to cis-1, 2-dihydroxy-1,2-dihydronaphthalene and cis-2,3-dihydroxy-2, 3-dihydrobiphenyl, respectively. On the other hand, CARDO also catalyzed the monooxygenation of sulfur heteroatoms in dibenzothiophene and of the benzylic methylenic group in fluorene to yield dibenzothiophene-5-oxide and 9-hydroxyfluorene, respectively. These results indicate that CARDO has a broad substrate range and can catalyze diverse oxygenation: angular dioxygenation, cis dihydroxylation, and monooxygenation. The diverse oxygenation catalyzed by CARDO for several aromatic compounds might reflect the differences in the binding of the substrates to the reaction center of CARDO.  (+info)

Pharmacokinetics and pharmacodynamics of Ro 44-3888 after single ascending oral doses of sibrafiban, an oral platelet aggregation inhibitor, in healthy male volunteers. (7/1106)

AIMS: This study constituted the first administration of the oral platelet inhibitor, sibrafiban, to humans. The aim was to investigate the pharmacokinetics and pharmacodynamics of Ro 44-3888, the active principle of sibrafiban, after single ascending oral doses of sibrafiban. Particular emphasis was placed on intersubject variability of the pharmacokinetic and pharmacodynamic parameters of Ro 44-3888. METHODS: The study consisted of three parts. Part I was an open ascending-dose study to determine target effect ranges of sibrafiban. Part II, a double-blind, placebo-controlled, parallel-group study, addressed the intersubject variability of pharmacokinetic and pharmacodynamic parameters of the active principle at a sibrafiban dose achieving an intermediate effect. Part III was a double-blind, placebo-controlled, ascending-dose design covering the complete plasma concentration vs pharmacodynamic response curve of sibrafiban. RESULTS: At sibrafiban doses between 5 mg and 12 mg, the pharmacokinetics of free Ro 44-3888 in plasma were linear whereas those of total Ro 44-3888 were non-linear because of the saturable binding to the glycoprotein IIb-IIIa receptor. Saturation of the GP IIb-IIIa receptor was reached at plasma concentrations of 15.9 ng ml-1. At sibrafiban doses up to 2 mg, ADP-induced platelet aggregation was inhibited by 50%, whereas the inhibition of TRAP-induced platelet aggregation was about 20-30%. At the higher doses, ADP-induced platelet aggregation was almost completely inhibited while a clear dose-response could be observed with TRAP-induced inhibition of platelet aggregation at sibrafiban doses of 5 to 12 mg. Ivy bleeding time increased very steeply with dose with a significant prolongation observed at doses of 5 to 7 mg of sibrafiban (5-7 min, >30 min in one case). At a sibrafiban dose of 12 mg, the stopping criterion for dose escalation (prolongation of the Ivy bleeding time >30 min in three out of four subjects per dose group) was reached. The interindividual coefficients of variation of the integrated pharmacokinetic and pharmacodynamic parameters (AUC and AUE) were below 20%, thus lying well within the pre-set level of acceptance. CONCLUSIONS: With a low intersubject variability of its pharmacokinetic and pharmacodynamic parameters, linear pharmacokinetics and pharmacodynamic effects closely related to its plasma concentrations, Ro 44-3888 has good pharmacological prerequisites for a well controllable therapy of secondary prevention of arterial thrombosis in patients with acute coronary syndrome.  (+info)

Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4. (8/1106)

The emergence of X4 human immunodeficiency virus type 1 (HIV-1) strains in HIV-1-infected individuals has been associated with CD4(+) T-cell depletion, HIV-mediated CD8(+) cell apoptosis, and an impaired humoral response. The bicyclam AMD3100, a selective antagonist of CXCR4, selected for the outgrowth of R5 virus after cultivation of mixtures of the laboratory-adapted R5 (BaL) and X4 (NL4-3) HIV strains in the presence of the compound. The addition of AMD3100 to peripheral blood mononuclear cells infected with X4 or R5X4 clinical HIV isolates displaying the syncytium-inducing phenotype resulted in a complete suppression of X4 variants and a concomitant genotypic change in the V2 and V3 loops of the envelope gp120 glycoprotein. The recovered viruses corresponded genotypically and phenotypically to R5 variants in that they could no longer use CXCR4 as coreceptor or induce syncytium formation in MT-2 cells. Furthermore, the phenotype and genotype of a cloned R5 HIV-1 virus converted to those of the R5X4 virus after prolonged culture in lymphoid cells. However, these changes did not occur when the infected cells were cultured in the presence of AMD3100, despite low levels of virus replication. Our findings indicate that selective blockade of the CXCR4 receptor prevents the switch from the less pathogenic R5 HIV to the more pathogenic X4 HIV strains, a process that heralds the onset of AIDS. In this article, we show that it could be possible to redirect the evolution of HIV so as to impede the emergence of X4 strains or to change the phenotype of already-existing X4 isolates to R5.  (+info)

Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis - Chemical Communications (RSC Publishing)Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis - Chemical Communications (RSC Publishing)
The Pd-catalysed asymmetric intramolecular α-arylation of amideenolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used.
http://pubs.rsc.org/en/Content/ArticleLanding/2008/CC/b810858g
Chemistry of Heterocyclic Compounds
Advances in Heterocyclic Chemistry - 1st Edition - ISBN: 9780124201606, 9780124202092. Paal-Knorr Reaction in the Synthesis of Heterocyclic Compounds.. Thiophene and Its Derivatives, Part 2 (The Chemistry of ... Buy Thiophene and Its Derivatives, Part 2 (The Chemistry of Heterocyclic Compounds, Vol. 44) on Amazon.com ✓ FREE SHIPPING on qualified orders. Chemistry of Heterocyclic Compounds Profession. Heterocyclic compounds are presumably the largest class of organic compounds, obtaining great diversity in chemical and physical properties. Thus Chemistry of Heterocyclic Compounds - CRC Press Book Dec 22, 2014 This book discusses the structure, synthesis, and reactivity of heterocyclic compounds. It covers nomenclature, conformational aspects, Heterocyclic Chemistry - MSU Chemistry Devising a systematic nomenclature system for heterocyclic compounds presented a formidable challenge, which has not been uniformly concluded. Thiophene and Its Derivatives, Part 2 (The Chemistry of ... Buy Thiophene ...
https://plancul-belge.be/16489.php
Wholesale Chemistry Heterocyclic Compounds from Chemistry Heterocyclic Compounds Supplier - benzophenonederivatives
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Design and Synthesis of Polycyclic Imidazole-Containing N-Heterocycles based on C-H Activation/Cyclization Reactions - EnamineDesign and Synthesis of Polycyclic Imidazole-Containing N-Heterocycles based on C-H Activation/Cyclization Reactions - Enamine
A new strategy for the synthesis of polycyclic imidazole-containing N-heterocycles, based on the two general synthetic ways, namely the Pd(II)-catalyzed intramolecular arylation via CH/C-Hal and CH/CH coupling reactions, was developed. The method proposed here enables the synthesis of many fused N-heterocycles containing purine, 1-deazapurines and benzimidazole structural units.. ...
https://enamine.net/research/publications/392-design-and-synthesis-of-polycyclic-imidazole-containing-n-heterocycles-based-on-c-h-activation-cyclization-reactions
9780470380826:The Chemistry of Heterocyclic Compounds, Heterocyclic Systems with Bridgehead Nitrogen Atoms : Printsasia.com9780470380826:The Chemistry of Heterocyclic Compounds, Heterocyclic Systems with Bridgehead Nitrogen Atoms : Printsasia.com
Book The Chemistry of Heterocyclic Compounds, Heterocyclic Systems with Bridgehead Nitrogen Atoms: 9780470380826, 0470380829 by W.L. Mosby.Free shipping within USA.
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Heterocyclic CompoundHeterocyclic Compound
The list of heterocyclic compounds includes many different classifications of heterocyclic compounds, such as aromatic and nitrogen compounds. Find the best heterocyclic compound supplier and product from Echemi.com
http://www.echemi.com/category/heterocyclic-compound-c1111.html
Heterocyclic compound - WikipediaHeterocyclic compound - Wikipedia
Although heterocyclic chemical compounds may be inorganic compounds or organic compounds, most contain at least one carbon. While atoms that are neither carbon nor hydrogen are normally referred to in organic chemistry as heteroatoms, this is usually in comparison to the all-carbon backbone. But this does not prevent a compound such as borazine (which has no carbon atoms) from being labelled heterocyclic. IUPAC recommends the Hantzsch-Widman nomenclature for naming heterocyclic compounds. Heterocyclic compounds can be usefully classified based on their electronic structure. The saturated heterocycles behave like the acyclic derivatives. Thus, piperidine and tetrahydrofuran are conventional amines and ethers, with modified steric profiles. Therefore, the study of heterocyclic chemistry focuses especially on unsaturated derivatives, and the preponderance of work and applications involves unstrained 5- and 6-membered rings. Included are pyridine, thiophene, pyrrole, and furan. Another large class ...
https://en.wikipedia.org/wiki/Heterocyclic_ring
Heterocyclic compound - Comparison with carbocyclic compounds | chemistry | Britannica.comHeterocyclic compound - Comparison with carbocyclic compounds | chemistry | Britannica.com
Heterocyclic compound - Comparison with carbocyclic compounds: The molecules of organic chemical compounds are built up from a framework or backbone of carbon atoms to which are attached hydrogen (H), oxygen, or other heteroatoms. Carbon atoms have the unique property of being able to link with one another to form chains of atoms. When the ends of the chains are joined together into a ring, cyclic compounds result; such substances often are referred to as carbocyclic or alicyclic compounds. Substitution of one or more of the ring carbon atoms in the molecules of a carbocyclic compound with a heteroatom gives a heterocyclic compound. A typical carbocyclic compound
https://www.britannica.com/science/heterocyclic-compound/Comparison-with-carbocyclic-compounds
Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands - University of Huddersfield...Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands - University of Huddersfield...
A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.. ...
http://eprints.hud.ac.uk/id/eprint/23474/
Dearomatization of electron poor six-membered N-heterocycles through [3 + 2] annulation with aminocyclopropanes - Chemical...Dearomatization of electron poor six-membered N-heterocycles through [3 + 2] annulation with aminocyclopropanes - Chemical...
Many abundant and highly bioactive natural alkaloids contain an indolizidine skeleton. A simple, high yielding method to synthesize this scaffold from N-heterocycles was developed. A wide range of pyridines, quinolines and isoquinolines reacted with donor-acceptor (DA)-aminocyclopropanes via an ytterbium(iii
http://pubs.rsc.org/en/content/articlelanding/2017/sc/c7sc03197a
Plerixafor (AMD3100) and Bevacizumab for Recurrent High-Grade Glioma - Full Text View - ClinicalTrials.govPlerixafor (AMD3100) and Bevacizumab for Recurrent High-Grade Glioma - Full Text View - ClinicalTrials.gov
Plerixafor in combination with bevacizumab is a drug combination that may stop cancer cells from growing abnormally. Bevacizumab, also known as Avastin, is FDA approved for use in patients with recurrent glioblastoma and has been studied extensively in other types of solid tumors. Plerixafor, also known as Mozobil, is FDA approved for use in patients with non-Hodgkins lymphoma and multiple myeloma and has been used in treatment for other cancers. Information from experiments in laboratories suggests that the combination of plerixafor and bevacizumab may help prevent the growth of gliomas.. Part 1: The investigators are looking for the highest dose of plerixafor that can be given safely with bevacizumab (with a 21 days on/7 days off regimen of plerixafor). The investigators will also do blood tests to find out how the body uses and breaks down the drug combination.. Part 2: The investigators are looking to see if plerixafor can get past the blood-brain barrier and into brain tumors. The ...
https://clinicaltrials.gov/ct2/show/NCT01339039?cond=%22Anaplastic+oligoastrocytoma%22&rank=19
Plerixafor (AMD3100) and Bevacizumab for Recurrent High-Grade Glioma - Full Text View - ClinicalTrials.govPlerixafor (AMD3100) and Bevacizumab for Recurrent High-Grade Glioma - Full Text View - ClinicalTrials.gov
Plerixafor in combination with bevacizumab is a drug combination that may stop cancer cells from growing abnormally. Bevacizumab, also known as Avastin, is FDA approved for use in patients with recurrent glioblastoma and has been studied extensively in other types of solid tumors. Plerixafor, also known as Mozobil, is FDA approved for use in patients with non-Hodgkins lymphoma and multiple myeloma and has been used in treatment for other cancers. Information from experiments in laboratories suggests that the combination of plerixafor and bevacizumab may help prevent the growth of gliomas.. Part 1: The investigators are looking for the highest dose of plerixafor that can be given safely with bevacizumab (with a 21 days on/7 days off regimen of plerixafor). The investigators will also do blood tests to find out how the body uses and breaks down the drug combination.. Part 2: The investigators are looking to see if plerixafor can get past the blood-brain barrier and into brain tumors. The ...
https://clinicaltrials.gov/ct2/show/NCT01339039?cond=%22Anaplastic+oligoastrocytoma%22&rank=14
Heterocyclic compound
The study of heterocyclic chemistry focuses especially on unsaturated derivatives, and the preponderance of work and applications involves unstrained 5- and 6-membered rings. Included are pyridine, thiophene, pyrrole, and furan. Another large class of heterocycles refers to those fused to benzene rings. For example, the fused benzene derivatives of pyridine, thiophene, pyrrole, and furan are quinoline, benzothiophene, indole, and benzofuran, respectively. The fusion of two benzene rings gives rise to a third large family of compounds. Analogs of the previously mentioned heterocycles for this third family of compounds are acridine, dibenzothiophene, carbazole, and dibenzofuran, respectively. Heterocyclic compounds can be usefully classified based on their electronic structure. The saturated heterocycles behave like the acyclic derivatives. Thus, piperidine and tetrahydrofuran are conventional amines and ethers, with modified steric profiles. Therefore, the study of heterocyclic chemistry focuses ...
https://library.kiwix.org/wikipedia_en_top_maxi/A/Heterocyclic_compound
Akhilesh Kumar VermaAkhilesh Kumar Verma
An efficient strategy for the synthesis of α,β-unsaturated enaminones by the nucleophilic addition of N-heterocycles such as indole and imidazoles onto electronically bias alkynones under mild reaction conditions is described. Key feature of this reaction is the chemoselective addition of N-heterocycles onto ynones without affecting the 1° amino groups (aromatic and aliphatic) of 5-aminoindole and tryptamine. The stereochemistry of the products was controlled by the tuning of reaction time. The mechanism of the reaction involves the Michael type addition of N-heterocycles on ynones via allene formation.. ...
https://www.ias.ac.in/listing/bibliography/jcsc/Akhilesh_Kumar_Verma
IE59144B1 - Heterocyclic compounds as fungicides - Google Patents
C07D207/34-Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms ...
https://patents.google.com/patent/IE59144B1/en
844-Mobilisation of peripheral blood stem cells using plerixafor and G-CSF | eviQ844-Mobilisation of peripheral blood stem cells using plerixafor and G-CSF | eviQ
In the two phase III randomized trials, 298 patients with NHLr and 302 with MMr were recruited. In the NHL group, the primary end point (,5 x 106 CD34+ cells/kg) was reached in 59% of the plerixafor-treated patients and 20% of those who received placebo (P,0.001). In the plerixafor group, 86.7% obtained at least 2 x 106 CD34+ cells/kg, compared to 47.3% in the placebo group, which is considered the minimum requirement to safely proceed to autologous transplant (P,0.001). Results were similar in the MM study, where the primary end point (,6 x 106 CD34+ cells/kg) was reached in 71.6% in the plerixafor group and 34.4% in the placebo group (P,0.001). Comparing between groups for the achievement of at least 2 x 106 CD34+ cells/kg, this was also higher in patients given plerixafor at 95.3% versus 88.3% (P=.031). Fifty-four percent of patients met the primary endpoint after one apheresis following plerixafor, while 56% of patients receiving placebo required four apheresis sessions to reach this ...
https://www.eviq.org.au/haematology-and-bmt/blood-and-marrow-transplant/mobilisation/844-mobilisation-of-peripheral-blood-stem-cells-us
Plerixafor HCl | AMD3100 | CAS#110078-46-1 | CAS#155148-31-5 | MedKoo BiosciencesPlerixafor HCl | AMD3100 | CAS#110078-46-1 | CAS#155148-31-5 | MedKoo Biosciences
Plerixafor, also known as AMD3100, is a bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Plerixafor was approved by the U.S. Food and Drug Administration for this indication on December 15, 2008. In Europe, the drug was approved on 29 May 2009.
https://www.medkoo.com/products/4726
The Chemistry of Heterocyclic Compounds, Pyridine and Its Derivatives: Supplement | Ebook | Ellibs EbookstoreThe Chemistry of Heterocyclic Compounds, Pyridine and Its Derivatives: Supplement | Ebook | Ellibs Ebookstore
Ellibs Ebookstore - Ebook: The Chemistry of Heterocyclic Compounds, Pyridine and Its Derivatives: Supplement - Author: Abramovitch, R. A. - Price: 422,40€
https://www.ellibs.com/book/9780470188132/the-chemistry-of-heterocyclic-compounds-pyridine-and-its-derivatives-supplement
Download Chemistry Of Heterocyclic Compounds: The Pyrimidines: Supplement Ii, Volume 16 1985
download Chemistry of Heterocyclic Compounds: The Pyrimidines: Supplement II, Volume 16 1985 told with a V on the typewriter need, Checking the Inertial value. The common SmartApps of the cell diffusion found to travel cell 8 cases almost, providing as a supply in a unstylish chance information. 10 64 discourse, product service language.
http://divemasterexi.de/BILDER/freebooks.php?q=download-Chemistry-of-Heterocyclic-Compounds%3A-The-Pyrimidines%3A-Supplement-II%2C-Volume-16-1985.php
Heterocyclic Compounds, 4 or More Rings | Semantic ScholarHeterocyclic Compounds, 4 or More Rings | Semantic Scholar
A class of heterocyclic compounds that include four or more fused rings. Both aromatic or non-aromatic ring structures are included in this category.
https://www.semanticscholar.org/topic/Heterocyclic-Compounds%2C-4-or-More-Rings/4139238
Nitrogen only heterocyclic compounds sales value UK 2010-2018 | StatistaNitrogen only heterocyclic compounds sales value UK 2010-2018 | Statista
This statistic shows the sales value of heterocyclic compounds with nitrogen only hetero-atom(s) based on PRODCOM estimates** in the United Kingdom (UK) between 2010 and 2018.
https://www.statista.com/statistics/328479/heterocyclic-compounds-nitrogen-only-hetero-atoms-sales-value-in-the-united-kingdom-uk/
Acyclic, Carbocyclic, or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen,...Acyclic, Carbocyclic, or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen,...
The invention relates to an N-heterocyclic carbene complex of general formulas I to IV (I) (II) (III) (IV), according to which A1 stands for NR2 or PR2, A2 stands for CR2R2, NR2, PR2, O or S, A3 stands for N or P, and C stands for a car ...
http://www.sumobrain.com/ICL-C07F11.html
CG-DRUG-76 Plerixafor Injection (Mozobil™)
Collecting sufficient CD34+ autologous stem cells could enable eligible individuals with specific malignancies to proceed to autologous hematopoietic stem cell transplantation (HSCT). Plerixafor injection is a hematopoietic stem cell mobilizer that is given subcutaneously (SQ) with granulocyte colony stimulating factor (G-CSF). Also known as AMD3100 in early clinical studies, plerixafor injection is the first agent in a class of small molecules that reversibly inhibits the CXCR4 chemokine receptor and blocks binding of the stromal cell-derived factor-1α (SDF-1α). CXCR4 and SDF-1α play a role in the homing of human HSC to the bone marrow (DiPersio, 2009b; Product Information Label, 2013). HSC binding is inhibited with plerixafor injection which releases (mobilizes) CD34+ stem cells from the marrow into the bloodstream where they can be collected through apheresis for subsequent autologous HSCT to treat individuals with multiple myeloma (MM) or non-Hodgkin lymphoma (NHL) (Giralt, 2009).. The ...
https://www.unicare.com/medicalpolicies/guidelines/gl_pw_d056016.htm
NHC Organocatalytic Formal LUMO Activation of α,β-Unsaturated Esters for Reaction with Enamides - Cheng - 2013 - Angewandte...NHC Organocatalytic Formal LUMO Activation of α,β-Unsaturated Esters for Reaction with Enamides - Cheng - 2013 - Angewandte...
An effective wake-up call: Stable α,β-unsaturated esters were activated by the addition of a chiral N-heterocyclic carbene (NHC) organocatalyst, and the resulting reactive Michael acceptor intermediates reacted with enamide nucleophiles to furnish optically pure products (see scheme; Ts=p-toluenesulfonyl). These products can be converted readily into bioactive δ-lactams, piperidines, and their derivatives. ...
http://onlinelibrary.wiley.com/doi/10.1002/anie.201303247/full
Easton Axis N-Fused Carbon Arrow | Sportsmans WarehouseEaston Axis N-Fused Carbon Arrow | Sportsmans Warehouse
Easton Axis N-Fused Carbon Arrow 6 pack- These pre-fletched arrows are a favorite choice of serious bowhunters. The small diameter high strength Axis N-Fused arrow is deep penetrating on big game. - Sportsmans Warehouse
http://www.sportsmanswarehouse.com/sportsmans/Easton-Axis-N-Fused-Carbon-Arrow/productDetail/Carbon-Arrows/prod999901362503/cat100545
The synthesis of five- and six-membered heterocyclic compounds | Principles of Organic Synthesis | Taylor & Francis GroupThe synthesis of five- and six-membered heterocyclic compounds | Principles of Organic Synthesis | Taylor & Francis Group
Heterocyclic systems are of widespread occurrence in nature, particularly in such natural products as nucleic acids, plant alkaloids, anthocyanins and flavones,
https://www.taylorfrancis.com/books/9780203742068/chapters/10.1201/9780203742068-23
Caffeine-Based Gold(I) N-Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological PropertiesCaffeine-Based Gold(I) N-Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological Properties
A new series of gold(I) N-heterocyclic carbene (NHC) complexes based on xanthine ligands have been synthesized and characterized by mass spectrometry, NMR, and X-ray diffraction. The compounds hav ...
http://www.chemeurope.com/en/publications/654923/caffeine-based-gold-i-n-heterocyclic-carbenes-as-possible-anticancer-agents-synthesis-and-biological-properties.html
Johnson Group Journal Blog: (N-heterocyclic carbene)-Pd catalyzed synthesis of poly(triarylamine)s by Buchwald-Hartwig coupling...Johnson Group Journal Blog: (N-heterocyclic carbene)-Pd catalyzed synthesis of poly(triarylamine)s by Buchwald-Hartwig coupling...
The use of an air and moisture stable, commercially available (N-heterocyclic carbene)-Pd complex as precatalyst allows for the Buchwald-Hartwig polyamination of aryl chlorides with primary amines. Different approaches for the end-capping of the polymers have also been evaluated. The step growth polymerizations exhibit molecular weight from 2000 to 15000 Da and PDI from 1.1 (2000 Da) to 3.0 ...
http://johnsonmit.blogspot.com/2012/08/n-heterocyclic-carbene-pd-catalyzed.html
One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines<...
TY - JOUR. T1 - One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines. AU - Martinez-Ariza, Guillermo. AU - McConnell, Nicholas. AU - Hulme, Christopher. PY - 2016/4/15. Y1 - 2016/4/15. N2 - A cesium carbonate promoted three-component reaction of N-H containing heterocycles, primary or secondary amines, arylglyoxaldehydes, and anilines is reported. The key step involves a tandem sequence of N-1 addition of a heterocycle or an amine to preformed α-iminoketones, followed by an air- or oxygen-mediated oxidation to form α-oxo-acetamidines. The scope of the reaction is enticingly broad, and this novel methodology is applied toward the synthesis of various polycyclic heterocycles.. AB - A cesium carbonate promoted three-component reaction of N-H containing heterocycles, primary or secondary amines, arylglyoxaldehydes, and anilines is reported. The key step involves a tandem sequence of N-1 addition of a heterocycle or an amine to ...
https://arizona.pure.elsevier.com/en/publications/one-pot-two-step-multicomponent-process-of-indole-and-other-nitro
Plerixafor - AdisInsightPlerixafor - AdisInsight
Plerixafor is a bicyclam derivative that acts as a stem cell mobiliser by blocking the CXCR4 chemokine receptor. Plerixafor was synthesized by Johnson Matthey
http://adisinsight.springer.com/drugs/800002496?error=cookies_not_supported&code=72b00056-9c52-4f51-a7dd-dc45a8c381c1
Phosphorus-sulfur heterocycles incorporating an O-P(S)-O or O-P(S)-S-S-P(S)-O scaffold : one-pot synthesis and crystal...Phosphorus-sulfur heterocycles incorporating an O-P(S)-O or O-P(S)-S-S-P(S)-O scaffold : one-pot synthesis and crystal...
A new one-pot preparative route was developed to synthesize novel organophosphorus sulfur heterocycles via the reaction of the four-membered ring thionation reagent [2,4-diferrocenyl 1,3,2,4-diathiadiphosphetane 2,4-disulfide (FcLR, a ferrocene analogue of Lawessons reagent)] and alkenyl/aryl-diols and I2 (or SOCl2) in the presence of triethylamine. Therefore, a series of five- to ten-membered heterocycles bearing an O-P(S)-O or an O-P(S)-S-S-P(S)-O linkage were synthesized. The synthesis features a novel application of the multicomponent reaction, providing an efficient and environmentally benign method for the preparation of the unusual phosphorus-sulfur heterocycles. Seven representative X-ray structures confirm the formation of these heterocycles ...
https://research-repository.st-andrews.ac.uk/handle/10023/11878
CHEMISTRY OF HETEROCYCLIC COMPOUNDSCHEMISTRY OF HETEROCYCLIC COMPOUNDS
Nomenclature. Electrophilic substitutions reactions of fNomenclature. Electrophilic substitutions reactions of furan, thiophene, pyrrole, indole, benzofuran and benzothiophene; reactions with bases, nucleophiles and metallations reactions. Synthesis of Paal-Knorr, Knorr, Hantzsch, Feist-Benary, Fischer, Reissert. The use of N-oxides of pyridine in substitution reactions of the pyridine nucleus. Reaction of Chichibabin and metallation of the alkyl pyridines. Synthesis from 1,5-diketones, followed by oxidation, synthesis of Hantzsch. Synthesis of pyrimidine nucleus from 1,3-dicarbonyl compounds (β-diketones + amidine, β-diketones + guanidine). Electrophilic and nucleophilic substitutions reactions of quinolines and isoquinolines. Skraup and Bischler-Napieralski synthesis.. ...
https://en.uniss.it/ugov/degreecourse/78215
OPUS Würzburg | SearchOPUS Würzburg | Search
The addition of alkynes to a staturated N-heterocyclic carbene (NHC)-supported diboryne results in spontaneous cycloaddition, with complete B≡B and C≡C triple bond cleavage, NHC ring- expansion and activation of a variety of C-H bonds, leading to the formation of complex mixtures of fused B,N-heterocycles ...
https://opus.bibliothek.uni-wuerzburg.de/solrsearch/index/search/searchtype/all/rows/20/languagefq/eng/sortfield/year/sortorder/desc/start/0/facetNumber_author_facet/all/author_facetfq/He%C3%9F%2C+Merlin/yearfq/2019/subjectfq/alkynes
Institute of Cancer Research Repository - A large potentiation effect of serum on the invitro potency of tulathromycin against...
The antimicrobial properties of tulathromycin were investigated for M.haemolytica and P.multocida. Three invitro indices of antimicrobial activity, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill curves, were established for six isolates of each organism. Each index was measured in two growth media: Mueller-Hinton broth (MHB) and calf serum. It was shown that MICs and MBCs were markedly lower in serum than in MHB. MHB:serum ratios for MIC were 47:1 (M.haemolytica) and 53:1 (P.multocida). For both serum and MHB, adjustment of pH led to greater potency at alkaline compared to acid pH. Tulathromycin MIC was influenced by size of inoculum count, being 4.0- to 7.7-fold greater for high compared to low initial counts. It was concluded that for the purpose of determining dosages for therapeutic use, pharmacodynamic data for tulathromycin should be derived in biological fluids such as serum. It is hypothesized that invitro measurement of MIC in broth, ...
http://publications.icr.ac.uk/16273/
BALLYA Tulathromycin Test - BALLYABALLYA Tulathromycin Test - BALLYA
BALLYA test for tulathromycin used for detection tulathromycin residues in feed and food. Just only 15 minutes to result. Rapid test manufacturer directly supply. Low cost, worldwide shipping. BALLYA Tulathromycin test kit wholesale.
https://ballyabio.com/ballya-tulathromycin-test/
Molecules | Free Full-Text | Aminoacids in the Synthesis of Heterocyclic Systems: The Synthesis of Triazinoquinazolinones,...Molecules | Free Full-Text | Aminoacids in the Synthesis of Heterocyclic Systems: The Synthesis of Triazinoquinazolinones,...
A number of novel triazinoquinazolinones (5b,c and 8), triazepinoquinazolinones(5a, 6b, 7 and 9) and triazocinoquinazolinones (6a and 10) were obtained via nucleophilic interaction of 3-aminoquinazolinone derivatives 3 with different reagents.
http://www.mdpi.com/1420-3049/6/3/267
Professor Satoshi Omura | Molecules | Macrosphelide
MSB inhibits adhesion of sialyl Lewisx (sLex)-expressing HL-60 cells to LSP-activated (E-selectin-expressing) HUVECs in vitro. When MSB was administered to B16/BL6 mice at 20 mg/kg/day, lung metastatic nodules of B16/BL6 mouse melanoma cells (B16/BL6 cells) were significantly decreased (T/C = 45%). Flow cytometry analysis showed that B16/BL6 cells expressed high levels of sLex antigens. Under in vitro conditions, B16/BL6 cells demonstrated a greater degree of adhesion to LSP-activated HUVECs, but adhesion was significantly inhibited by MSB and sLex antibodies. Combined therapy of MSB and cisplatin (CDDP) induced remarkable lung metastasis inhibition without the adverse effects, of CDDP to the host.. ...
http://satoshi-omura.info/molecules/macrosphelidee.html
N-Heterocyclic Carbene (NHC) Compounds | Sigma-AldrichN-Heterocyclic Carbene (NHC) Compounds | Sigma-Aldrich
Beginning in 2004, Bode and co-workers extended the use of NHCs as organocatalysts by developing new approaches to the catalytic generation of reactive species including activated carboxylates, homoenolates, and enolates. Critical to the success of these processes is an N-mesityl substituent on an imidazolium or triazolium NHC precursor. These novel catalysts and reactions make possible a new generation of highly enantioselective annulations from simple starting materials under mild reaction conditions, usually at room temperature and without added reagents. For example, chiral (683973) catalyzes an inverseelectron demand Diels-Alder reaction of activated enals and α,β-unsaturated imines to afford cis-dihydropyridinones with outstanding selectivity (Scheme 2).3 The use of α-chloro aldehydes as starting materials is viable, and also makes possible enantioselective annulations with enones using less than 1 mol % of the chiral NHC catalysts (Scheme 3).4 These catalysts promote highly ...
https://www.sigmaaldrich.com/technical-documents/articles/chemfiles/n-heterocyclic-carbene.html
Application # 2016/0229812. SALT OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR CRYSTAL THEREOF, PHARMACEUTICAL...
An object of the present invention is to provide a compound and pharmaceutical composition showing superior stability and/or solubility, etc. and having superior FLT3 inhibitory activity. The present
http://patents.com/us-20160229812.html
Heterocyclic CompoundsHeterocyclic Compounds
ChemApproach is a worldwide supplier of the unique high-quality building blocks to R&D facilities in pharmaceutical and agriculture industries, academical institutions, aromatic compounds, Hi-Tech companies, etc.
https://chemapproach.com/heterocyclic-compounds.html?cat=145
[email protected]: Synthesis and studies on some substituted pyrazole pyrimidine heterocyclic compounds and their metal...
The [email protected] Centre provides a platform for research students to deposit their Ph.D. theses and make it available to the entire scholarly community in open access. Shodhganga Mirror Site ...
http://shodhganga.inflibnet.ac.in:8080/jspui/handle/10603/81653
Acyclic, Carbocyclic, or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen,...Acyclic, Carbocyclic, or Heterocyclic Compounds Containing Elements Other Than Carbon, Hydrogen, Halogen, Oxygen, Nitrogen,...
The present invention relates to the compounds of Formula 1 wherein M is Sc or Y, Hal is CI, Br, F or I R is alkyl with 1 - 4 atoms of C X is CI, Br, F or I or a group such as that shown hereinafter wherein R is alkyl with 1 - 4 atoms of ...
http://www.sumobrain.com/ICL-C07F17.html
6-Membered Heterocyclic Compounds [Chemical Structural Class] | TCI EUROPE N.V.6-Membered Heterocyclic Compounds [Chemical Structural Class] | TCI EUROPE N.V.
TCI uses cookies to personalize and improve your user experience. By continuing on our website, you accept the use of cookies. You can change or update your cookiesettings at any time.. ...
https://www.tcichemicals.com/BE/en/c/00548/
Indian Patents. 212547:A PROCESS FOR THE PREPARATION OF A MAGNESIUM SALT OF A SUBSTITUTED SULPHINYL HETEROCYCLIC COMPOUNDS.
5 -Methoxy-2 [ [(4-methoxy-3,5 -dimethyl-2-pyridinyl)methyl]sulfinyl] -1 H-benzimidazole (25 g, 72.4 mmol) together with isopropylamine (7.4 ml, 86.9 mmol) was added to methanol (100 ml). To the mixture Mg(NO3)2 x 6 H2O (11.2 g, 43.7 mmol) was added at ambient temperature. After the reaction was completed inorganic salts were removed by means of filtration. Water was added to the filtrate, the mixture was filtered and the filter cake was washed with methanol (10 ml). Water (100 ml) was added dropwise to the combined organic layers. The product was filtered off and was washed with a mixture of MeOH/water (50 ml, 1:1). The product was dried overnight. Yield: 89%. (Mg content: 3.39; calculated theoretically: 3.41 ...
http://www.allindianpatents.com/patents/212547-a-process-for-the-preparation-of-a-magnesium-salt-of-a-substituted-sulphinyl-heterocyclic-compounds
鐘萼木枝葉之含硫生物鹼成分研究 臺灣博碩士論文知識加值系統鐘萼木枝葉之含硫生物鹼成分研究 臺灣博碩士論文知識加值系統
本論文主要研究鍾萼木 (Bretshneidera sinensis Hemsley)的含硫生物鹼成分，先將其枝葉部分用酒精萃取後，得到的萃取物再利用各種管柱色層分離方法進行分離，最後再用儀器鑑定其所含的化學組成成分。實驗結果共分離了六個化合物，六個都為首次發現的含硫之生物鹼 (sulfur-containing alkaloids)。分離得到的新化合物中，共有四個屬於3-methyl-1,3-benzothiazine-2,4-dione骨架的雜環化合物 (heterocyclic compounds, 1-4)及兩個骨架為 N-benzyl-S-methyl-thiocarbamate的含硫生物鹼 (5-6)分離得到的化合物結構利用核磁共振圖譜1D NMR (1H NMR 和 13C NMR)及2D NMR (HSQC、HMBC)進行結構解析，再加上各種物理數據分析，包含熔點、紫外線吸收光普及高解析電灑式質譜儀，最後再利用化學結構資料庫 (Reaxys)進行相關文獻比對確認。所分離得到的新化合物已送測抗發炎以及抗癌細胞的生物活性檢測。
https://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22102NTU05551004%22.&searchmode=basic
2017/Nr 6] Effects of two new synthesized heterocyclic compounds on proliferation and tube... - Acta Poloniae Pharmaceutica -...2017/Nr 6] Effects of two new synthesized heterocyclic compounds on proliferation and tube... - Acta Poloniae Pharmaceutica -...
Towarzystwo o profilu zawodowo-naukowym, którego działalność skupia się głównie na wspieraniu rozwoju nauk farmaceutycznych oraz reprezentacji zawodu farmaceuty, założone w 1947 z siedzibą w Warszawie.
https://ptfarm.pl/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/27136
Patents 5162466 - 5162723
ORGANIC COMPOUNDS -- PART OF THE CLASS 532-570 SERIES : : : Hetero ring is five-membered consisting of one nitrogen and four carbons (e.g., halopyrrolidines, etc.) : Polycyclo ring system having the five-membered hetero ring as one of the cyclos : Bicyclo ring system having the five-membered hetero ring as one of the cyclos (e.g., octahydroindoles, etc.) : Additional polycyclo heterocyclic ring system attached directly or indirectly to the bicyclo ring system by nonionic bonding : The additional polycyclo heterocyclic ring system has a lactone ring as one of the cyclos : Ring carbon of each of the two five-membered hetero rings is bonded directly to chalcogen or nitrogen (e.g., both rings may be bonded to the same nitrogen atom or to different nitrogen atoms, etc ...
http://www.everypatent.com/idx/pdir639.html
PDF] Ag(I) N-heterocyclic carbene complexes: synthesis, structure, and application. | Semantic ScholarPDF] Ag(I) N-heterocyclic carbene complexes: synthesis, structure, and application. | Semantic Scholar
Öfele and Wanzlick first pioneered the metalation of imidazol-2-ylidenes, better known as N-heterocyclic carbenes (NHCs), from imidazolium salts in 1968.1,2 Lappert and co-workers followed this work with the investigation of N-heterocyclic carbene complexes synthesized from electron-rich olefins.3,4 However, it was not until the isolation of the first free carbene by Arduengo, in 1991, that significant interest was given to the area.5 Since then the complexation chemistry of these new ligands has become a major area of research.6-10 This new class of ligand has shown to equal, if not exceed, phosphines in their ability to bind to a variety of metals. Complexes of N-heterocyclic carbenes with virtually every transition metal and many main group elements have been reported.1-10 N-Heterocyclic carbenes bind to both hard and soft metals making it a very versatile ligand system. NHCs bond to metals primarily through σ donation of the carbene lone pair to the metal. The bonding of the carbene was believed
https://www.semanticscholar.org/paper/Ag
Polycyclic N-heterocyclic compounds. Part 70: Synthesis of 5-amino-1,2-dihydrofuro[2,3-b]pyrido[3,2:4,5]-thieno[3,2-d...
TY - JOUR. T1 - Polycyclic N-heterocyclic compounds. Part 70. T2 - Synthesis of 5-amino-1,2-dihydrofuro[2,3-b]pyrido[3,2:4,5]-thieno[3,2-d]pyridines and related compounds. Evaluation of effects on lipoprotein lipase mRNA expression. AU - Okuda, Kensuke. AU - Takechi, Hideyasu. AU - Hirota, Takashi. AU - Sasaki, Kenji. PY - 2011/5/26. Y1 - 2011/5/26. N2 - Reaction of 3-(3-cyanopropoxy)thieno[2,3-b]pyridine-2-carbonitriles with potassium tert-butoxide gave 5-amino-1,2-dihydrofuro[2,3-b]pyrido- [3,2:4,5]thieno[3,2-d]pyridines via a Truce-Smiles rearrangement. The 5-amino group was transformed to the chloro derivatives which were allowed to react with various nucleophiles. Effects of the newly synthesized compounds on lipoprotein lipase mRNA expression were also evaluated. The previously unreported parent compound, furo[2,3-b]pyrido[3,2:4,5]thieno[3,2-d]pyridine, was also synthesized.. AB - Reaction of 3-(3-cyanopropoxy)thieno[2,3-b]pyridine-2-carbonitriles with potassium tert-butoxide gave ...
https://okayama.pure.elsevier.com/en/publications/polycyclic-n-heterocyclic-compounds-part-70-synthesis-of-5-amino-
Ruthenium complexes bearing two N-heterocyclic carbene ligands in low catalyst loading olefin metathesis reactionsRuthenium complexes bearing two N-heterocyclic carbene ligands in low catalyst loading olefin metathesis reactions
article{8169264, abstract = {The synthesis of ruthenium indenylidene complexes containing mixed N-heterocyclic carbene ligands featuring one sterically small NHC [IMe(Me) (1,3,4,5-tetramethylimidazol-2-ylidene), I(i)Pr(Me) (1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene), and ICy (1,3-dicyclohexylimidazol-2-ylidene)] and one larger congener SIMes (1,3-bis-(2,4,6 trimethylphenyl)imidazolin-2-ylidene) is described. Characterization by X-ray diffraction allowed for calculation of percent buried volume of the small NHCs in these complexes and for speculation on the relationship NHC/catalytic activity. In addition, these complexes displayed an enhanced stability but also a high ability to promote ring-closing metathesis reactions at catalyst loadings as low as 0.05 mol %.}, author = {Bantreil, Xavier and Randall, Rebecca AM and Slawin, Alexandra MZ and Nolan, Steven}, issn = {0276-7333}, journal = {ORGANOMETALLICS}, keywords = {RING-CLOSING METATHESIS,INDENYLIDENE COMPLEXES,TETRASUBSTITUTED ...
https://biblio.ugent.be/publication/8169264
Metal-mediated Heterocyclization: Synthesis of Heterocyclic Compounds Containing More Than One Heteroatom Through Carbon...Metal-mediated Heterocyclization: Synthesis of Heterocyclic Compounds Containing More Than One Heteroatom Through Carbon...
Title: Metal-mediated Heterocyclization: Synthesis of Heterocyclic Compounds Containing More Than One Heteroatom Through Carbon-Heteroatom Bond Forming Reactions. VOLUME: 14 ISSUE: 8. Author(s):K. C. Majumdar, B. Roy, P. Debnath and A. Taher. Affiliation:Department of Chemistry, University of Kalyani, Kalyani- 741 235, India.. Abstract: Heterocyclic compounds are versatile building blocks in organic synthesis. These are important part in various natural products and bioactive compounds. Several methodologies have been developed to synthesize these heterocyclic compounds. This review article covers an updated (published during 2005 to 2008) summary of transition-metal catalyzed approaches for the syntheses of commonring heterocycles containing more than one heteroatom via the selective formation of carbon-heteroatom bonds. The five-membered ring heterocycles with two nitrogen atoms include imidazoles, pyrazoles, indazoles, imidazoindolones etc. and heterocycles with one nitrogen and one oxygen ...
https://www.eurekaselect.com/71436/article/metal-mediated-heterocyclization-synthesis-heterocyclic-compounds-containing-more-one
DFT and Quantum Chemical Studies for Heterocyclic Compounds / 978-3-659-21601-5 / 9783659216015 / 3659216011DFT and Quantum Chemical Studies for Heterocyclic Compounds / 978-3-659-21601-5 / 9783659216015 / 3659216011
DFT and Quantum Chemical Studies for Heterocyclic Compounds, 978-3-659-21601-5, 9783659216015, 3659216011, Inorganic chemistry , The study of corrosion processes and their inhibition by organic inhibitors is a very active field of research. The presence of nitrogen, oxygen, phosphorous and sulphur in the organic molecules has a major effect on the inhibition efficiency and consequently on the phenomenon of adsorption on some metals surface. A great number of heterocyclic compounds were found to be excellent inhibitors of copper and steel corrosion. The inhibition effect mainly depends on some physicochemical and electronic properties of the organic inhibitor which relate to its functional groups, steric effects, electronic density of donor atoms, and orbital character of donating electrons. DFT Quantum chemical methods have already proven to be very useful in determining the molecular structure as well as elucidating the electronic structure and reactivity. Thus, it has become a common practice to
https://www.lap-publishing.com/catalog/details/store/ru/book/978-3-659-21601-5/dft-andquantum-chemical-studies-for-heterocyclic-compounds
US Patent for Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors Patent (Patent # 6,207,669 issued March...US Patent for Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors Patent (Patent # 6,207,669 issued March...
Substituted heteroaromatic compounds, and in particular substituted bicyclic heteroaromatic compounds in which one ring is a pyridine or pyrimidine of formula (I) are protein tyrosine kinase inhibitors. The compounds are described as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of cancer and psoriasis.
https://patents.justia.com/patent/6207669
Efficient and phosphine-free bidentate N-heterocyclic carbene/ruthenium catalytic systems for the dehydrogenative amidation of...
TY - JOUR. T1 - Efficient and phosphine-free bidentate N-heterocyclic carbene/ruthenium catalytic systems for the dehydrogenative amidation of alcohols and amines. AU - Wu, Xuan Jun. AU - Wang, Hua Jing. AU - Yang, Zhao Qi. AU - Tang, Xiao Sheng. AU - Yuan, Ye. AU - Su, Wei. AU - Chen, Cheng. AU - Verpoort, Francis. PY - 2019/3/7. Y1 - 2019/3/7. N2 - The direct amide synthesis from alcohols and amines applying various transition metal catalysts has been demonstrated as an attractive and promising process. Among various catalytic systems, N-heterocyclic carbene (NHC)-based ruthenium (Ru) ones have been testified to be active for this atom-economic transformation. Although a variety of imidazole-based NHC/Ru catalytic systems were reported to be active for this reaction, the benzimidazole-based analogs exhibited higher catalytic performance in most cases. However, these catalytic systems, which comprise a monodentate NHC ligand and a Cl or phosphine ligand as the key components, require relatively ...
https://tpu.pure.elsevier.com/en/publications/efficient-and-phosphine-free-bidentate-n-heterocyclic-carbeneruth
Palladium (0) olefin complexes bearing purine-based N-heterocyclic carbenes and 1,3,5-triaza-7-phosphaadamantane (PTA):...
TY - JOUR. T1 - Palladium (0) olefin complexes bearing purine-based N-heterocyclic carbenes and 1,3,5-triaza-7-phosphaadamantane (PTA). T2 - Synthesis, characterization and antiproliferative activity toward human ovarian cancer cell lines. AU - Scattolin, Thomas. AU - Pangerc, Nicola. AU - Lampronti, Ilaria. AU - Tupini, Chiara. AU - Gambari, Roberto. AU - Marvelli, Lorenza. AU - Rizzolio, Flavio. AU - Demitri, Nicola. AU - Canovese, Luciano. AU - Visentin, Fabiano. PY - 2019/10/30. Y1 - 2019/10/30. N2 - A complete series of new η2-olefin palladium (0) complexes bearing purine-based N-heterocyclic carbenes or PTA (1,3,5-triaza-7-phospaadamantane) as spectator ligands have been synthetized and exhaustively characterized. The first single-crystal X-ray structure of a PTA complex of palladium (0) have been also reported. The most part of these compounds have been tested as antiproliferative agents toward two different human ovarian cancer cell lines A2780 and A2780cis, respectively cisplatin ...
https://moh-it.pure.elsevier.com/en/publications/palladium-0-olefin-complexes-bearing-purine-based-n-heterocyclic-
N-Methyl-N-nitrosotoluene-4-sulphonamide - Buy Heterocyclic compound, Thiophene compounds, Aromatics Product on Baoji GuoKang...N-Methyl-N-nitrosotoluene-4-sulphonamide - Buy Heterocyclic compound, Thiophene compounds, Aromatics Product on Baoji GuoKang...
N-Methyl-N-nitrosotoluene-4-sulphonamide, find complete details about N-Methyl-N-nitrosotoluene-4-sulphonamide, Heterocyclic compound, Thiophene compounds, Aromatics - Baoji GuoKang Bio-Technology Co., Ltd.
http://www.gk-bio.com/N-Methyl-N-nitrosotoluene-4-sulphonamide-pd6535224.html
N-Heterocyclic Carbene as Self-Assembled Monolayers on Gold and CarbonN-Heterocyclic Carbene as Self-Assembled Monolayers on Gold and Carbon
N-Heterocyclic carbenes (NHCs) have been shown to be exceptional ligands for molecular coordination chemistry due to their ability to form strong carbon-metal bonds. Only recent, our group and others have demonstrated that the strong carbon-metal bonding properties of NHCs can be leveraged for materials chemistry. In 2014, Crudden and co-workers showed that self-assembled monolayers (SAMs) derived from NHCs on gold surfaces were significantly more stable than thiolate SAMs; which, for decades, have been considered the state-of-the-art in SAM chemistry. Since then, our group has continued to advance the field by incorporating unique functionalities to NHCs and new methods of SAM formation. In addition, stability of NHCs in different chemical and electrochemical conditions was critical to determine NHCs use in biological and industrial applications. In this thesis, I will present the use of electrochemical measurement of NHCs in phosphate buffer are discussed to confirm the prospective use of ...
https://qspace.library.queensu.ca/handle/1974/27818?show=full
Heterocyclic Derivatives Of Phosphorous, Arsenic, Antimony And Bismuth (The Chemistry Of Heterocyclic Compounds, Volume 1, 2Nd...Heterocyclic Derivatives Of Phosphorous, Arsenic, Antimony And Bismuth (The Chemistry Of Heterocyclic Compounds, Volume 1, 2Nd...
in a system of third chromosomiche. Isaac, Mike( April 30, 2019). Facebook Unveils Redesign as It oude to be Past Privacy Scandals . All the pre-Columbian independence from Facebooks F8 seller . artifacts from F8 and Facebooks own need . Facebook Investor Relations. men, Alexia( February 1, 2012). Facebooks future: An spring To All The attachment placement . Arrington, Michael( May 19, 2009). Facebook Turns Down billion Valuation Term Sheet, Claims 2009 movies Will be authoritative million . ties, Alexia( January 5, 2011). aloneness: Facebook Revenue had similar Million In 2009, early Income 0 Million . Womack, Brian( December 16, 2010). Heterocyclic Derivatives of Phosphorous, Arsenic, Antimony and Bismuth (The Chemistry of Heterocyclic Compounds, Volume 1, 2nd Edition) 2010 subgroupings represented much to Reach Billion, More Than been . Facebook Reports other moment and synonymous internet 2012 Drugs . been February 7, 2014. Facebook Reports celestial immortality and small toddler ...
http://dataprintusa.com/dpsite/wp-content/themes/pdf.php?q=Heterocyclic-Derivatives-of-Phosphorous%2C-Arsenic%2C-Antimony-and-Bismuth-%28The-Chemistry-of-Heterocyclic-Compounds%2C-Volume-1%2C-2nd-Edition%29/
From Heterocyclic Compound Containing A Sulfur Atom As A Ring Member Patents and Patent Applications (Class 528/377) - Justia...From Heterocyclic Compound Containing A Sulfur Atom As A Ring Member Patents and Patent Applications (Class 528/377) - Justia...
Search for From Heterocyclic Compound Containing A Sulfur Atom As A Ring Member Patents and Patent Applications (Class 528/377) Filed with the USPTO
https://patents.justia.com/patents-by-us-classification/528/377
Chemistry Of Heterocyclic Compounds Isoxazoles Part 2 Volume 49 1999
You begin chemistry of heterocyclic compounds isoxazoles part 2 volume is originally deliver! Your Web Introduction is right dated for work. Some blocks of WorldCat will well offer internal.
https://octavachamberorchestra.com/audio/steve/book/chemistry-of-heterocyclic-compounds-isoxazoles-part-2-volume-49-1999/
Heterocyclic compounds; lactams; other than 6-hexanelactam (epsilon caprolactam) exports by country |2018Heterocyclic compounds; lactams; other than 6-hexanelactam (epsilon caprolactam) exports by country |2018
In 2018, Top exporters of Heterocyclic compounds; lactams; other than 6-hexanelactam (epsilon caprolactam) are Ireland ($7,633,206.93K , 27,279 Kg), Belgium ($7,187,788.89K , 15,915,500 Kg), European Union ($2,162,593.57K , 38,129,100 Kg), Singapore ($1,075,335.30K , 712,056 Kg), United Kingdom ($823,439.86K , 254,932 Kg ...
https://wits.worldbank.org/trade/comtrade/en/country/ALL/year/2018/tradeflow/Exports/partner/WLD/product/293379
Heterocyclic amine formation in meat - WikipediaHeterocyclic amine formation in meat - Wikipedia
Heterocyclic amines are a group of chemical compounds, many of which can be formed during cooking. They are found in meats that are cooked to the well done stage, in pan drippings and in meat surfaces that show a brown or black crust. Epidemiological studies show associations between intakes of heterocyclic amines and cancers of the colon, rectum, breast, prostate, pancreas, lung, stomach/esophagus and animal feeding experiments support a causal relationship. The U.S. Department of Health and Human Services Public Health Service labeled several heterocyclic amines as likely carcinogens in its 13th Report on Carcinogens. Changes in cooking techniques reduce the level of heterocyclic amines. More than 20 compounds fall into the category of heterocyclic amines, often abbreviated HCAs[1]. Table 1 shows the chemical name and abbreviation of those most commonly studied. All four of these compounds are included in the 13th Report on Carcinogens. The compounds found in food are formed when creatine (a ...
https://en.wikipedia.org/wiki/Heterocyclic_amine_formation_in_meat
Heteroaromatic compounds and their use as dopamine D1 ligands - UTMB Health Research Expert ProfilesHeteroaromatic compounds and their use as dopamine D1 ligands - UTMB Health Research Expert Profiles
TY - PAT. T1 - Heteroaromatic compounds and their use as dopamine D1 ligands. AU - Allen, John. PY - 2017/4/11. Y1 - 2017/4/11. UR - http://pdfpiw.uspto.gov/.piw?Docid=09617275&homeurl=http%3A%2F%2Fpatft.uspto.gov%2Fnetacgi%2Fnph-Parser%3FSect1%3DPTO2%2526Sect2%3DHITOFF%2526p%3D1%2526u%3D%25252Fnetahtml%25252FPTO%25252Fsearch-bool.html%2526r%3D4%2526f%3DG%2526l%3D50%2526co1%3DAND%2526d%3DPTXT%2526s1%3D9,617,275%2526OS%3D9,617,275%2526RS%3D9,617,275&PageNum=&Rtype=&SectionNum=&idkey=NONE&Input=View+first+page. M3 - Patent. M1 - 9,617,275 B2. PB - United States Patent Office. ER - ...
https://researchexperts.utmb.edu/en/publications/heteroaromatic-compounds-and-their-use-as-dopamine-d1-ligands-2/
Room temperature synthesis of glycerol carbonate catalyzed by N-heterocyclic carbenes - Fingerprint - Research Nebraska
Dive into the research topics of Room temperature synthesis of glycerol carbonate catalyzed by N-heterocyclic carbenes. Together they form a unique fingerprint. ...
https://experts.nebraska.edu/en/publications/room-temperature-synthesis-of-glycerol-carbonate-catalyzed-by-n-h/fingerprints/
Synthesis of medicinally privileged heterocycles through dielectric heatingSynthesis of medicinally privileged heterocycles through dielectric heating
Heterocyclic compounds are enormously crucial in various industries including food, agricultural, cosmetics and pharmaceuticals. Heterocyclic pharmacophores are one of the main chemical components in drug discovery research. A report in 2013 claims that four out of six and nine out of twenty one highest selling medicines in the world are small molecule heterocyclic compounds. Therefore, easy access of medicinally active heterocycles or drug candidates is essential for a routine structure-activity relationship (SAR) study. Reactions under environmentally benign conditions following green chemistry techniques are a subject of intensive investigation. Microwave-induced rapid synthesis of organic compounds helps to reduce waste formation by reducing unwanted side reactions, maintaining atom economy, and providing products with high yield and, in many instances, with predictable stereochemistry.. Since the discovery of microwave-induced reactions in synthetic organic chemistry in 1986, this method ...
https://mail.benthamscience.com/recent-trends/RT-20170616-001/
Umicore Hoveyda-Grubbs Catalyst M710 | Precious Metals ChemistryUmicore Hoveyda-Grubbs Catalyst M710 | Precious Metals Chemistry
CAS Number: 1025728-56-6. Product class: Homogeneous Catalysts, Hoveyda-Grubbs Catalyst® 2nd Generation, M-C, Carbene Ligands, Alkoxybenzylidene Ligands, N-Heterocyclic Carbene Ligands, SIMes. Reaction type: Alkene Metathesis, Cross Metathesis, Ring Closing Metathesis, Self Metathesis. ...
https://pmc.umicore.com/en/products/umicore-hoveyda-grubbs-catalyst-m710/
Adelaide Research & Scholarship: The Role of Lysine Amino Nitrogen in the Biosynthesis of Mousy Off-Flavor Compounds by Dekkera...Adelaide Research & Scholarship: The Role of Lysine Amino Nitrogen in the Biosynthesis of Mousy Off-Flavor Compounds by Dekkera...
Mousy off-flavor is an insidious and economically disastrous microbiologically derived spoilage characteristic of wine and other fermented beverages. Tainted wines are rendered unpalatable and there is currently no satisfactory procedure for removal of the off-flavor. Here we report the confirmation of that both D- and L-lysine can act as a precursor for the formation of mousy off-flavor N-heterocycles. Further, through the use of stable isotope feeding experiments, we could establish that a pentylamine group from lysine is incorporated into the piperideine moiety of two off-flavor N-heterocycles. A biochemical pathway for the formation of mousy off-flavor compounds is proposed ...
https://digital.library.adelaide.edu.au/dspace/handle/2440/40821
METHODS FOR DIAGNOSIS AND TREATMENT OF ENDOMETRIAL CANCER - Patent applicationMETHODS FOR DIAGNOSIS AND TREATMENT OF ENDOMETRIAL CANCER - Patent application
0118] wherein R1 is a cycloalkyl group, a cycloalkyl group having a substituent(s), wherein, when the cycloalkyl group is a cyclopropyl group said cyclopropyl group has a substituent(s), a cycloalkenyl group or a cycloalkenyl group having a substituent(s); each R2 and R3 is a hydrogen atom or an alkyl group; R4 is an alkyl group, an alkyl group having a substituent(s), an alkenyl group, an alkenyl group having a substituent(s), a cycloalkyl group, a cycloalkyl group having a substituent(s), a cycloalkenyl group, a cycloalkenyl group having a substituent(s), an aryl group, an aryl group having a substituent(s), an aromatic heterocyclic group having at least one hetero-atom within a ring or an aromatic heterocyclic group having a substituent(s) and at least one hetero-atom within a ring; A is a heterocyclic ring or a heterocyclic ring having a substituent(s); B is an aromatic ring, an aromatic ring having a substituent(s), a heterocyclic ring or a heterocyclic ring having a substituent(s); n is an ...
http://www.patentsencyclopedia.com/app/20120264620
John L Lemanowicz - Attorney Patent Directory, Page 1
Directory of patents filed by John L Lemanowicz (123 patents): Method for forming pluralities of droplets and polymer particles having low polydispersity; Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors; Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors; Fused heterocyclic compounds as protein tyrosine kinase inhibitors; Process and apparatus for forming plastic sheet
http://patent.ipexl.com/attorney/john_l_lemanowicz_1.html
Synthesis and Reactions of Binuclear Diolefin Rhodium(I) Compounds bridged by Nitrogen Heterocycles, Crystal Structure of...
Binuclear complexes of rhodium(I) of the type [(dien)(X)Rh(μ-N-N)Rh(X)(dien)] (dien = 1,5-cyclooctadiene or norbornadiene; N-N = pyrazine, 4,4′-bipyridine or Phenazine and X = Cl or Br) with bridging heterocycles have been isolated and their reactions with carbon monoxide, 2,2′-bipyridine and 1,10-phenanthroline investigated. The crystal structure of [(COD)(Cl)Rh(μ-pyrazine)Rh(Cl)(COD)] has been determined.. ...
http://eprints.iisc.ernet.in/20530/
Chemical markers of heterocyclic aromatic amines for human biomonitoring | National Agricultural LibraryChemical markers of heterocyclic aromatic amines for human biomonitoring | National Agricultural Library
Prostate Cancer is the most frequently diagnosed malignancy and second leading cause of cancer-related Death among men in the United States. Identifying risk factors of this disease and developing strategies for prevention are critical. A number of epidemiologic studies have reported an association between frequent consumption of well-done cooked meats, containing the heterocyclic aromatic amine (HAA) 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine (PhIP) and Prostate Cancer risk. PhIP is a potent rodent prostate carcinogen, and it induces oxidative stress, atrophy of the acini, and inflammation of the prostate. These are critical features that occur in human prostate carcinogenesis. A paradigm has been put forth for a causal role of consumption of well-done cooked meats containing PhIP (and other HAAs) in the etiology of Prostate Cancer; however, biomarkers of exposure and DNA damage are lacking to validate this model. Our long-term goal is to assess the cancer risk posed by HAAs, by employing ...
https://www.nal.usda.gov/fsrio/research-projects/chemical-markers-heterocyclic-aromatic-amines-human-biomonitoring
Potential of synchronous fluorescence spectroscopy coupled with chemometrics to determine the heterocyclic aromatic amines in...Potential of synchronous fluorescence spectroscopy coupled with chemometrics to determine the heterocyclic aromatic amines in...
In this study, the potential of synchronous front-face fluorescence spectroscopy (SFS) coupled with chemometrics was investigated for the determination of heterocyclic aromatic amines (HAA) in coo ...
https://www.bionity.com/en/publications/188882/potential-of-synchronous-fluorescence-spectroscopy-coupled-with-chemometrics-to-determine-the-heterocyclic-aromatic-amines-in-grilled-meat.html
The synthesis and antimicrobial activity of heterocyclic derivatives of totarol<...
TY - JOUR. T1 - The synthesis and antimicrobial activity of heterocyclic derivatives of totarol. AU - Kim, Michelle B.. AU - OBrien, Terrence E.. AU - Moore, Jared T.. AU - Anderson, David E.. AU - Foss, Marie H.. AU - Weibel, Douglas B.. AU - Ames, James B.. AU - Shaw, Jared T.. PY - 2012/10/11. Y1 - 2012/10/11. N2 - The synthesis and antimicrobial activity of heterocyclic analogues of the diterpenoid totarol are described. An advanced synthetic intermediate with a ketone on the A-ring is used to attach fused heterocycles, and a carbon-to-nitrogen atom replacement is made on the B-ring by de novo synthesis. A-ring analogues with an indole attached exhibit, for the first time, enhanced antimicrobial activity relative to the parent natural product. Preliminary experiments demonstrate that the indole analogues do not target the bacterial cell division protein FtsZ as had been hypothesized for totarol.. AB - The synthesis and antimicrobial activity of heterocyclic analogues of the diterpenoid ...
https://ucdavis.pure.elsevier.com/en/publications/the-synthesis-and-antimicrobial-activity-of-heterocyclic-derivati
Patent US6927294 - Nitrogen-containing heterocycles - Google PatentsPatent US6927294 - Nitrogen-containing heterocycles - Google Patents
Functionalized nitrogen heterocyclic compounds, including benzodiazepines and azasugars, and synthetic methods for preparing such compounds. Nitrogen-containing heterocycles are prepared by reacting amino-carbonyl compounds that contain an amine moiety connected via a linker to a carbonyl moiety with an organoboron derivative.
http://www.google.com/patents/US6927294?dq=6,563,928
Umicore Grubbs Catalyst M201 | Precious Metals ChemistryUmicore Grubbs Catalyst M201 | Precious Metals Chemistry
CAS Number: 1307233-23-3. Product class: Homogeneous Catalysts, Grubbs Catalyst® 2nd Generation, M-C, N-Heterocyclic Carbene Ligands, SIPr, M-P, Phosphorus Ligands - Achiral. Reaction type: Alkene Metathesis, Cross Metathesis, Enyne Metathesis, Ring Closing Metathesis, Self Metathesis. ...
https://pmc.umicore.com/en/products/umicore-hoveyda-grubbs-catalyst-m720/umicore-grubbs-catalyst-m201/
IUCr) Di-hydro-cyclam dimaleate [H2(cyclam)(maleate)2]IUCr) Di-hydro-cyclam dimaleate [H2(cyclam)(maleate)2]
Cyclam is doubly protonated in [H2(cyclam)(maleate)2], resulting in a maleate monoanion. The di-protonated cyclam [C10H26N4]2+ exhibits bond distances and angles in the range usually found in the literature (Melson, 1979). The two additional protons on N1 and N1A are trans to each other and interact through hydrogen bonds with the nonprotonated N2 and N2A nitrogen atoms [N1···N2= 2.800 (1) Å, N3···N4= 2.805 (1) Å]. The diprotonated macrocycle adopts an quadrangular (3,4,3,4)-C conformation (Fig. 1) according to Dales nomenclature [(Dale, 1973 and 1976, (Hancock et al., 1996)], where the exo-cyclic nitrogen atom N2 is located two bonds away from the adjacent corner atoms C9A and C11, while the amine nitrogen atom N1A is located one bond away from the corresponding corner atom C9A and two bonds away from C11A. According to the stereochemical classification of 1,4,8,11 tetraazacyclotetradecane introduced by Bosnich et al. (1965), the cyclam ring adopts a trans-III geometry type, which, ...
http://journals.iucr.org/e/issues/2013/10/00/hb7135/index.html
SYNTHESIS AND ANTICANCER SCREENING OF HETEROCYCLIC COMPOUNDS BEARING PYRIMIDO [4, 5-B] QUINOLINE MOIETY | INTERNATIONAL JOURNAL...SYNTHESIS AND ANTICANCER SCREENING OF HETEROCYCLIC COMPOUNDS BEARING PYRIMIDO [4, 5-B] QUINOLINE MOIETY | INTERNATIONAL JOURNAL...
Abstract Due to your efforts diligent on quinoline nucleus new series containing pyrimido [4, 5-b] quinoline were synthesized via starting with the strategic 2-aminoquinoline-3-carbonitrile (2) intermediates to afford various pyrimido [4, 5-b] quinoline via cyclization with different reagents to get compounds 3-24. Compounds 3, 6, 9a, 9b, 12, 15, 16a, 16b, 17, 21 and 24 were tested for in vitro antitumor activity against human breast carcinoma (MCF-7) cell line, We found what we were hoping for where compound 6 was found the most active member (IC50= 48.54 μM) than the Doxorubicin as a reference drug with (IC50= 71.80 μM). To understand the interaction of binding sites with the target protein receptor, the docking study was performed using topoisomerase II. The results of in vitro cancer activity and docking study revealed that the synthesized compounds have potential cancer activity and can be further optimized and developed as a lead compound.. ...
https://ijpsr.com/bft-article/synthesis-and-anticancer-screening-of-heterocyclic-compounds-bearing-pyrimido-4-5-b-quinoline-moiety/
COMPOSITIONS AND METHODS FOR TREATMENT - Patent applicationCOMPOSITIONS AND METHODS FOR TREATMENT - Patent application
0121] U4 is an optionally substituted bivalent radical selected from the group C1-C6alkyl, C0-C6alkyl-Q, C2-C6alkenyl-Q, and C2-C6alkynyl-Q: where the substituents on any alkyl, alkenyl or alkynyl are 1-3 R38; Q4 is absent or is selected from the group --O--, --S(O)s--, --SO2--N(R30)--, --N(R30)--, --N(R30)--C(═O)--, --N(R30)--C(═O)--N(R30--), --N(R30)--C(═O)--O--, --N(R30)--SO2--, --C(═O)--O--, C(═O)--O--, -het-, --C(═O)--N(R30)--, --O--C(═O)--N(R30)--, --PO(OR30)O-- and --P(O)O--; where s is 0-2 and het is a mono- or bicyclic 5, 6, 7, 9 or 10 member heterocyclic ring, each ring containing 1-4 heteroatoms selected from N, O and S, where the heterocyclic ring may be saturated, partially saturated, or aromatic and any N or S being optionally oxidized, the heterocyclic ring being substituted with 0-3 R41; V4 is absent or is an optionally substituted bivalent group selected from C1-C6alkyl, C3-C8cycloalkyl, C0-C6alkyl-C6-C10aryl, and C0-C6alky-het; where the substituents on any alkyl ...
http://www.patentsencyclopedia.com/app/20140161872
Download Chemistry of Heterocyclic Compounds: Thiazole and Its by Metzger PDF - MAXLIFECO.COM Books
30e V for the second: it corresponds to the ionization of the lone pair of the amino group that is conjugated with the ring T system. 75 eV. 5 eV corresponding to the nitro group. All the assignments could be confirmed with good precision by CNDO/S calculations (Table 1-20). Bernardi et al. (131) have studied the halogen derivatives experimentally and theoretically. The experimental assignments have been compared successfully to theoretical results obtained by ab initio STO-3G and 4-31G methods (192, 193). Various isotopically labeled thiazoles have been synthezised for physicochemical purposes: 2- and 5-deutero and 25 I. 6N D2S0, at 118 for 8 days (111). 5 moles of nondeuterated thiazole, resulted from the thermal decarboxylation of thiazol-4-yldeuterocarboxylicacid (1 13). N-Thiazole was prepared from labeled thiourea through the Hantzsch cyclization with 1,2-dichloroethoxyethane, Sandmeyer bromination of the 2-aminothiazole, and reduction by zinc and acetic acid of the 15N-2-bromothiazole ...
http://maxlifeco.com/lib/chemistry-of-heterocyclic-compounds-thiazole-and-its-derivatives-part-one
Indian Patents. 211270:PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS
Process for preparing compounds of the formula (I) in which R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group, which may be substituted by alkyl, or a trimethylene group, which may be substituted by alkyl, X represents an oxygen or sulphur atom or the group in which R3 represents a hydrogen atom or an alkyl group, and Z represents an optionally substituted 5- or 6-membered heterocyclic group which contains at least two heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, or denotes an optionally substituted 3- or 4-pyridyl group, characterized in that compounds of the formula (II) in which A and X are each as defined above are reacted with compounds of the formula (III) in which R1 and Z are each as defined above and M1 denotes a halogen atom or the group -OSO2-M2, in which M2 denotes a C1-C6-alkyl group, an aryl group or OM3, where M3 denotes a C1-C6-alkyl group or an alkali metal, in the presence of an alcohol which is not or is ...
http://www.allindianpatents.com/patents/211270-process-for-preparing-heterocyclic-compounds
Polycyclic organic compounds, Heterocyclic compound, Alpha blockers, Drugs acting on the nervous system, Cyclic compounds,...
Oxetorone (INN), as oxetorone fumarate (USAN) (brand names Nocertone, Oxedix), is a serotonin antagonist, antihistamine, and alpha blocker used as an antimigraine drug. Association with hyperprolactinemia has been described ...
https://api.chemchart.com/search?search=Polycyclic+organic+compounds%2C+Heterocyclic+compound%2C+Alpha+blockers%2C+Drugs+acting+on+the+nervous+system%2C+Cyclic+compounds%2C+Analgesic%2C+Drugs+for+benign+prostatic+hyperplasia%2C+Drugs+acting+on+the+cardiovascular+system%2C+Urologicals%2C+Analgesics
Polycyclic organic compounds, Kappa agonists, Alkaloids, Heterocyclic compounds (4 or more rings), Drugs acting on the nervous...
Nonene is an alkene with the molecular formula C9H18. Many structural isomers are possible, depending on the location of the C=C double bond and the branching of the other parts of the molecule. Industrially, the most important nonenes are trimers of propene ...
http://api.chemchart.com/search?search=Polycyclic+organic+compounds%2C+Kappa+agonists%2C+Alkaloids%2C+Heterocyclic+compounds+%284+or+more+rings%29%2C+Drugs+acting+on+the+nervous+system
5-Membered Heterocyclic Compounds [Chemical Structural Class] | Tokyo Chemical Industry UK Ltd.5-Membered Heterocyclic Compounds [Chemical Structural Class] | Tokyo Chemical Industry UK Ltd.
TCI uses cookies to personalize and improve your user experience. By continuing on our website, you accept the use of cookies. You can change or update your cookiesettings at any time.. ...
https://www.tcichemicals.com/GB/en/c/00549
Nitro azines. 21. Reactivities and electron structures of 6-nitroazolo[1,5-a]pyrimidines<...
TY - JOUR. T1 - Nitro azines. 21. Reactivities and electron structures of 6-nitroazolo[1,5-a]pyrimidines. AU - Myasnikov, A. V.. AU - Torgashev, P. A.. AU - Pilicheva, T. L.. AU - Rusinov, V. L.. AU - Gromova, S. A.. AU - Trofimova, M. G.. AU - Velik, A. V.. AU - Chupakhin, O. N.. PY - 1993/6/1. Y1 - 1993/6/1. UR - http://www.scopus.com/inward/record.url?scp=34249772154&partnerID=8YFLogxK. U2 - 10.1007/BF00531550. DO - 10.1007/BF00531550. M3 - Article. AN - SCOPUS:34249772154. VL - 29. SP - 694. EP - 700. JO - Chemistry of Heterocyclic Compounds. JF - Chemistry of Heterocyclic Compounds. SN - 0009-3122. IS - 6. ER - ...
https://science.urfu.ru/ru/publications/nitro-azines-21-reactivities-and-electron-structures-of-6-nitroaz
Heterocyclic compoundHeterocyclic compound
Many drugs are heterocyclic compounds. IUPAC Gold Book heterocyclic compounds Thomas L. Gilchrist "Heterocyclic Chemistry" 3rd ... Wikimedia Commons has media related to heterocyclic compounds. Wikiquote has quotations related to Heterocyclic compound. ... highlighting the role of heterocyclic compounds (purines and pyrimidines) in the genetic code. Heterocyclic compounds are ... A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of ...
https://en.wikipedia.org/wiki/Heterocyclic_compound
Indole alkaloidIndole alkaloid
Orekhov, p. 616 L. Elderfild (1954). Heterocyclic compounds. Vol. 3. Moscow. p. 5.. Dewick, pp. 346-376. Hesse, pp. 14-30. ... Containing more than 4100 known different compounds, it is one of the largest classes of alkaloids. Many of them possess ... about 30 compounds, the most important of which is peduncularine - which contain a monoterpenoid C10 part originating not from ...
https://en.wikipedia.org/wiki/Indole_alkaloid
Hinsberg oxindole synthesisHinsberg oxindole synthesis
Friedel-Crafts alkylation Stolle synthesis Hinsberg reaction Elderfield, R.C. (1952). Heterocyclic Compounds. Vol. 3. New York ...
https://en.wikipedia.org/wiki/Hinsberg_oxindole_synthesis
PyrimidinePyrimidine
Kenner, G. W.; Todd, Alexander (1957). Elderfield, R.C. (ed.). Heterocyclic Compounds. Vol. 6. New York: Wiley. p. 235. Pinner ... Pyrimidine (C4H4N2; /pɪˈrɪ.mɪˌdiːn, paɪˈrɪ.mɪˌdiːn/) is an aromatic, heterocyclic, organic compound similar to pyridine (C5H5N ... The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6- ... However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic ...
https://en.wikipedia.org/wiki/Pyrimidine
UracilUracil
Heterocyclic Compounds. Vol. 52. New York, NY: Wiley. ISBN 9780471506560. Archived from the original on 12 May 2018. Horton HR ... The same compound is therefore represented as the methyl derivative of the compound, which I will arbitrarily endow with the ... It is a planar, unsaturated compound that has the ability to absorb light. Based on 12C/13C isotopic ratios of organic ... Myers RL, Myers RL (2007). The 100 Most Important Chemical Compounds. pp. 92-93. ISBN 9780313337581.[full citation needed] ...
https://en.wikipedia.org/wiki/Uracil
Phosphoryl chloridePhosphoryl chloride
ISBN 978-0-471-60180-7. Elderfield, R. C. (ed.). Heterocyclic Compound. Vol. 6. New York, NY: John Wiley & Sons. p. 265. Hurd, ... Bettermann, Gerhard; Krause, Werner; Riess, Gerhard; Hofmann, Thomas (2000). "Phosphorus Compounds, Inorganic". Ullmann's ... Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Articles without KEGG source ... which subsequently reacts with electron-rich aromatic compounds to produce aromatic aldehydes upon aqueous work-up. ...
https://en.wikipedia.org/wiki/Phosphoryl_chloride
Satinder Vir KessarSatinder Vir Kessar
Azasteroid Aporphine Heterocyclic compound India portal Chemistry portal His adviser for master's degree was S. M. Mukherji ... Kessar, Satinder; Kloetzal, Milton C. (1962). "Heterocyclic Compounds. X. Hydrogenated Derivatives of Isoindole and 2- ... Kessar, Satinder; Kloetzal, Milton C. (1962). "Heterocyclic Compounds. X. Hydrogenated Derivatives of Isoindole and 2- ... He is known for his researches in steroidal and heterocyclic chemistry. He is an elected fellow of The World Academy of ...
https://en.wikipedia.org/wiki/Satinder_Vir_Kessar
Ethylene oxideEthylene oxide
Section 4. Heterocyclic compounds. Triplex heterocyclic compounds". ChemAnalitica.com. 1 April 2009. Retrieved 21 September ... A series of polynomial heterocyclic compounds, known as crown ethers, can be synthesized with ethylene oxide. One method is the ... Ethylene oxide is an organic compound with the formula C2H4O. It is a cyclic ether and the simplest epoxide: a three-membered ... The heterocyclic triangular structure of ethylene oxide was proposed by 1868 or earlier. Wurtz's 1859 synthesis long remained ...
https://en.wikipedia.org/wiki/Ethylene_oxide
PyrrolePyrrole
... is a heterocyclic aromatic organic compound, a five-membered ring with the formula C4H4NH. It is a colorless volatile ... The Chemistry of Heterocyclic Compounds. Vol. 48. Chichester: John Wiley & Sons. p. 351. doi:10.1002/recl.19911100712. ISBN 978 ... Mosher, H. S. (1950). Elderfield, Robert Cooley (ed.). Heterocyclic Compounds. Vol. 1. New York, NY: Wiley. p. 475. "DPP ... Corwin, Alsoph Henry (1950). Elderfield, Robert Cooley (ed.). Heterocyclic Compounds. Vol. 1. New York, NY: Wiley. p. 309. ...
https://en.wikipedia.org/wiki/Pyrrole
Niementowski quinazoline synthesisNiementowski quinazoline synthesis
Williamson, T. A. (1957). "The chemistry of quinazoline". In Elderfield, R. C. (ed.). Heterocyclic Compounds. Vol. 6. New York ...
https://en.wikipedia.org/wiki/Niementowski_quinazoline_synthesis
Knorr pyrrole synthesisKnorr pyrrole synthesis
Heterocyclic Compounds. Vol. 1. New York: Wiley. pp. 287 ff. Fischer, Hans (1935). "2,4-Dimethyl-3,5-dicarbethoxypyrrole (2,4- ... Zanetti, C. U.; Levi, E. (1894). "Sintesi di composti pirrolici dai nitrosochetoni" [Synthesis of pyrrole compounds from ... and a compound containing an electron-withdrawing group (e.g. an ester as shown) α to a carbonyl group (2). The mechanism ...
https://en.wikipedia.org/wiki/Knorr_pyrrole_synthesis
Friedländer synthesisFriedländer synthesis
Bergstrom, F. W. (1944). "Heterocyclic Nitrogen Compounds. Part IIA. Hexacyclic Compounds: Pyridine, Quinoline, and ... In the first mechanism 2-amino substituted carbonyl compound 1 and carbonyl compound 2 react in a rate-limiting step to aldol ... adduct 3. This intermediate loses water in an elimination reaction to unsaturated carbonyl compound 4 and then loses water ...
https://en.wikipedia.org/wiki/Friedländer_synthesis
Doebner-Miller reactionDoebner-Miller reaction
Bergström, F. W. (1944). "Heterocyclic Nitrogen Compounds. Part IIA. Hexacyclic Compounds: Pyridine, Quinoline, and ... β-unsaturated carbonyl compound is prepared in situ from two carbonyl compounds (via an Aldol condensation), the reaction is ... The Doebner-Miller reaction is the organic reaction of an aniline with α,β-unsaturated carbonyl compounds to form quinolines. ... Because α-amino protons are not available in this model compound the reaction is not taken to the fully fledged quinoline. The ...
https://en.wikipedia.org/wiki/Doebner–Miller_reaction
Pfitzinger reactionPfitzinger reaction
Bergstrom, F. W. (1944). "Heterocyclic Nitrogen Compounds. Part IIA. Hexacyclic Compounds: Pyridine, Quinoline, and ... is the chemical reaction of isatin with base and a carbonyl compound to yield substituted quinoline-4-carboxylic acids. Several ...
https://en.wikipedia.org/wiki/Pfitzinger_reaction
BenzeneBenzene
"Heterocyclic Chemistry: Heterocyclic Compounds". Michigan State University, Department of Chemistry. Archived from the original ... He gave the compound the name benzin. In 1836, the French chemist Auguste Laurent named the substance "phène"; this word has ... Many important chemical compounds are derived from benzene by replacing one or more of its hydrogen atoms with another ... The aromatic compounds. Benzene.), pp. 125-129. Archived 2020-03-10 at the Wayback Machine See further: Thiele (1901) "Zur ...
https://en.wikipedia.org/wiki/Benzene
5-Hydroxy-2(5H)-furanone5-Hydroxy-2(5H)-furanone
Chemistry of Heterocyclic Compounds. 39 (5): 594-597. doi:10.1023/A:1025137914137. S2CID 98418207. (Articles without InChI ... Under some conditions the compound will isomerize into succinic anhydride. Upon heating in strongly basic solution (pH > 9) ...
https://en.wikipedia.org/wiki/5-Hydroxy-2(5H)-furanone
NitroethyleneNitroethylene
Chemistry of Heterocyclic Compounds. 45 (6): 748-749. doi:10.1007/s10593-009-0318-3. ISSN 0009-3122. Jasiński, Radomir (2009-09 ... Like most nitro compounds, a platinum/palladium catalyzed reaction with hydrogen gas can reduce the nitro group to an amine ... Nitroethylene (also known as nitroethene) is a liquid organic compound with the formula C2H3NO2. It is the simplest nitroalkene ...
https://en.wikipedia.org/wiki/Nitroethylene
2,4,6-Tris(trinitromethyl)-1,3,5-triazine2,4,6-Tris(trinitromethyl)-1,3,5-triazine
3. Reaction of 2,4,6-Tris(trinitromethyl)-1,3,5-triazine with Azides and Hydrazine". Chemistry of Heterocyclic Compounds. 39 (3 ... 2,4,6-Tris(trinitromethyl)-1,3,5-triazine is a chemical compound that is a derivative of triazine first prepared in 1995. It is ... Nitro compounds, Explosive chemicals, All stub articles, Explosives stubs). ...
https://en.wikipedia.org/wiki/2,4,6-Tris(trinitromethyl)-1,3,5-triazine
MeticraneMeticrane
Ukrainets IV, Bereznyakova NL (April 2012). "Heterocyclic diuretics". Chemistry of Heterocyclic Compounds. 48 (1): 155-65. doi: ...
https://en.wikipedia.org/wiki/Meticrane
MMB-2201MMB-2201
Chemistry of Heterocyclic Compounds. 50 (4): 583-586. doi:10.1007/s10593-014-1511-6. S2CID 97489753. Shevyrin V, Melkozerov V, ... Synthetic cannabinoid compounds with an indole-3-carboxamide or indazole-3-carboxamide core bearing a N-1-methoxycarbonyl group ... have proved to be much more dangerous than older synthetic cannabinoid compounds previously reported, and have been linked to ...
https://en.wikipedia.org/wiki/MMB-2201
Azomethine ylideAzomethine ylide
Chemistry of Heterocyclic Compounds: A Series of Monographs. Vol. 59. pp. 169-252. doi:10.1002/0471221902.ch3. ISBN ... Chemistry of Heterocyclic Compounds. 49 (1): 152-176. doi:10.1007/s10593-013-1236-y. S2CID 96192354. Nyerges, Miklós (2006). "1 ... The compounds resulting from this type of electrocyclization have been used as dienes in Diels-Alder reactions to attach ... While dipolarophiles are typically α,β-unsaturated carbonyl compounds, there have been many recent advances in developing new ...
https://en.wikipedia.org/wiki/Azomethine_ylide
Edwin VedejsEdwin Vedejs
Pēteris Trapencieris (2018). "Edwin Vedejs (1941-2017)". Chemistry of Heterocyclic Compounds. 53 (12): 1373-1374. doi:10.1007/ ...
https://en.wikipedia.org/wiki/Edwin_Vedejs
Kostanecki acylationKostanecki acylation
Synthesis and Structure of 2-Oxo-4-phenylpyrano[2,3-b]quinoxaline". Chemistry of Heterocyclic Compounds. 39 (1): 96-100. doi: ... Ellis, G. P. (1977) Chromenes, Chromanones, and Chromones from The Chemistry of Heterocyclic Compounds, Weissberger, A. and ...
https://en.wikipedia.org/wiki/Kostanecki_acylation
QuinazolineQuinazoline
Chemistry of Heterocyclic Compounds. Chemistry of Heterocyclic Compounds: A Series of Monographs. pp. 11-38. doi:10.1002/ ... W. L. F. Armarego (1967). "Halogenoquinazolines". In W. L. F. Armarego (ed.). Chemistry of Heterocyclic Compounds. pp. 11-38. ... Quinazoline is an organic compound with the formula C8H6N2. It is an aromatic heterocycle with a bicyclic structure consisting ... ISBN 978-0-85404-182-4. Armarego, W. L. F. (1963). "Quinazolines". Advances in Heterocyclic Chemistry Volume 1. Advances in ...
https://en.wikipedia.org/wiki/Quinazoline
2,3-Dihydrothiophene2,3-Dihydrothiophene
... is a heterocyclic compound and an organosulfur compound with the formula SC4H6. It is isomeric with the ... Synthesis and Properties (review)". Chemistry of Heterocyclic Compounds. 34 (10): 1101-1122. doi:10.1007/BF02319487. S2CID ... v t e (Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Articles without EBI ...
https://en.wikipedia.org/wiki/2,3-Dihydrothiophene
2-Bromoethyl ether2-Bromoethyl ether
Chemistry of Heterocyclic Compounds. 33 (1): 106-111. doi:10.1007/BF02290756. S2CID 95541398. Hansen, Thomas K.; Jørgensen, ... 2-Bromoethyl ether (or Bis(2-bromoethyl) ether) is an organobromine compound that is also an ether. It is used in the ...
https://en.wikipedia.org/wiki/2-Bromoethyl_ether
2,1,3-Benzothiadiazole2,1,3-Benzothiadiazole
Pesin, V. G.; Sergeev, V. A. (1969). "Research on 2,1,3-thia- and selenadiazole". Chemistry of Heterocyclic Compounds. 3 (5): ... Fedin, E. I.; Todres, Z. V. (1970). "Studies in the field of aromatic heterocycles" (pdf). Chemistry of Heterocyclic Compounds ... Pesin, V. G.; d'Yachenko, E. K. (1969). "Researches on 2,1,3-thia-and selenadiazole". Chemistry of Heterocyclic Compounds. 3: ... The crystal structure of the compound was determined in 1951, when it had the common name piazthiol(e). The extent of the ...
https://en.wikipedia.org/wiki/2,1,3-Benzothiadiazole
ImidazoloneImidazolone
... s are a family of heterocyclic compounds, the parents of which have the formula OC(NH)2(CH)2. Two isomers are ... Chemistry of Heterocyclic Compounds. 51: 395-420. doi:10.1007/s10593-015-1716-3. (Imidazoles). ...
https://en.wikipedia.org/wiki/Imidazolone
ArsoleArsole
... belongs to the series of heterocyclic pnictogen compounds. The naming of cyclic organoarsenic compounds such as arsole ... Tadeusz Marek Krygowski; Michal K. Cyrański; M. Agostinha R. Matos (2009). Aromaticity in Heterocyclic Compounds. Springer. pp ... Arsole, also called arsenole or arsacyclopentadiene, is an organoarsenic compound with the formula C4H4AsH. It is classified as ... Braye, E. H.; Hubel, W.; Caplier, I. (1961). "New Unsaturated Heterocyclic Systems. I". Journal of the American Chemical ...
https://en.wikipedia.org/wiki/Arsole
1,3,5-Triazine1,3,5-Triazine
Chemistry of Heterocyclic Compounds. 45 (2): 130-150. doi:10.1007/s10593-009-0243-5. S2CID 94191027. (Webarchive template ... 1,3,5-Triazine, also called s-triazine, is an organic chemical compound with the formula (HCN)3. It is a six-membered ... heterocyclic aromatic ring, one of several isomeric triazines. S-triazine-the "symmetric" isomer-and its derivatives are useful ...
https://en.wikipedia.org/wiki/1,3,5-Triazine
2C-B-DRAGONFLY2C-B-DRAGONFLY
Heterocyclic compounds with 3 rings, All stub articles, Nervous system drug stubs). ...
https://en.wikipedia.org/wiki/2C-B-DRAGONFLY
ChunganenolChunganenol
Heterocyclic compounds with 3 rings, Heterocyclic compounds with 5 rings, All stub articles, Aromatic compound stubs). ...
https://en.wikipedia.org/wiki/Chunganenol
MetabolismMetabolism
Organic compounds (proteins, lipids and carbohydrates) contain the majority of the carbon and nitrogen; most of the oxygen and ... These bases are heterocyclic rings containing nitrogen, classified as purines or pyrimidines. Nucleotides also act as coenzymes ... These compounds are made by the assembly and modification of isoprene units donated from the reactive precursors isopentenyl ... The fats are a large group of compounds that contain fatty acids and glycerol; a glycerol molecule attached to three fatty ...
https://en.wikipedia.org/wiki/Metabolism
G2ZTG2ZT
Azo compounds, Triazoles, All stub articles, Heterocyclic compound stubs). ... The compound is thus considered by its advocates to be an environmentally friendlier explosive than traditional nitroamine- ... Insensitive Energetic Compounds". Chemistry of Materials. 20 (11): 3629. doi:10.1021/cm703657k. v t e (Chemicals without a ...
https://en.wikipedia.org/wiki/G2ZT
MünchnoneMünchnone
doi:10.1002/anie.196401361) Gingrich, H. L.; Baum, J. S. In Oxazoles, Chemistry of Heterocyclic Compounds; Turchi, I. J., Ed.; ... is a mesoionic heterocyclic aromatic chemical compound, with the molecular formula C3H3NO2. The name refers to the city of ... Some new mesoionic compounds". Journal of the Chemical Society (Resumed): 2865-2871. doi:10.1039/JR9590002865. Huisgen, R.; ... Chemical compounds with unusual names Montréalone 5-Oxazolone (tautomer) Sydnone Sydnone imine Reissig, Hans-Ulrich; Zimmer, ...
https://en.wikipedia.org/wiki/Münchnone
DiazaquinoneDiazaquinone
A diazaquinone is a chemical compound that has an heterocyclic aromatic core including two consecutive doubly-bonded nitrogen ... doi:10.1021/ja00865a018 v t e (All stub articles, Organic chemistry stubs, Nitrogen compounds). ...
https://en.wikipedia.org/wiki/Diazaquinone
PyrrolobenzodiazepinePyrrolobenzodiazepine
Heterocyclic compound stubs). ... Pyrrolobenzodiazepines (PBD) are a class of compound that may ...
https://en.wikipedia.org/wiki/Pyrrolobenzodiazepine
Three Rings (disambiguation)Three Rings (disambiguation)
... a type of paper filing container Tricyclic chemical compounds (3-ringed chemical compounds) Heterocyclic compounds, 3-ring ...
https://en.wikipedia.org/wiki/Three_Rings_(disambiguation)
OxazolineOxazoline
It was named in-line with the Hantzsch-Widman nomenclature and is part of a family of heterocyclic compounds, where it exists ... Oxazoline is a five-membered heterocyclic chemical compound containing one atom each of oxygen and nitrogen. It was likely ... Oxazoline itself has no current applications however compounds containing the ring, which are referred to as oxazolines or ... CS1 German-language sources (de), CS1 maint: uses authors parameter, Chemical articles with multiple compound IDs, Multiple ...
https://en.wikipedia.org/wiki/Oxazoline
Bischler-Möhlau indole synthesisBischler-Möhlau indole synthesis
Carcinogenic nitrogen compounds. Part XXIV. The synthesis of indole and quinoline compounds from cyclic ketones". J. Chem. Soc ... Some heterocyclic quinols". Journal of the Chemical Society (Resumed): 3916. doi:10.1039/jr9540003916. ISSN 0368-1769. Japp, ...
https://en.wikipedia.org/wiki/Bischler–Möhlau_indole_synthesis
DibenzothiepinDibenzothiepin
Heterocyclic compound stubs, Dibenzothiepines). ... Dibenzothiepins are chemical compounds which are derivatives of ...
https://en.wikipedia.org/wiki/Dibenzothiepin
FlucindoleFlucindole
Heterocyclic compounds with 3 rings, All stub articles, Nervous system drug stubs). ... Dimethylamino compounds, Antipsychotics, Carbazoles, Fluoroarenes, Abandoned drugs, Nitrogen heterocycles, ...
https://en.wikipedia.org/wiki/Flucindole
PorphyrinPorphyrin
... s (/ˈpɔːrfərɪn/ POR-fər-in) are a group of heterocyclic macrocycle organic compounds, composed of four modified ... When there is no metal ion (or atom) bound to the nitrogens in the center, then the compounds are called free porphine or free ... Porphyrin-based compounds are of interest as possible components of molecular electronics and photonics. Synthetic porphyrin ... Porphin is the simplest porphyrin, a rare compound of theoretical interest. Representative porphyrins and derivatives ...
https://en.wikipedia.org/wiki/Porphyrin
C286C286
... gave heterocyclic compounds that were selective as RARβ agonists. The best was the highly potent RARβ agonist oxadiazole 2, ... A key element of this success has been the incorporation of heterocyclic linkers culminating in the discovery of the selective ... Replacing the amide linkage in the novel selective RARα agonist 1 with a series of 5-membered heterocyclic rings, ...
https://en.wikipedia.org/wiki/C286
ThienothiopheneThienothiophene
Heterocyclic compounds with 2 rings). ... Advances in Heterocyclic Chemistry. Advances in Heterocyclic ...
https://en.wikipedia.org/wiki/Thienothiophene
PirquinozolPirquinozol
Heterocyclic compounds with 3 rings, Nitrogen heterocycles, All stub articles, Respiratory system drug stubs). ...
https://en.wikipedia.org/wiki/Pirquinozol
Methyl isocyanideMethyl isocyanide
... is mainly used for making 5-membered heterocyclic rings. The C-N distance in methyl isocyanide is very short ... Methyl isocyanide or isocyanomethane is an organic compound and a member of the isocyanide family. This colorless liquid is ...
https://en.wikipedia.org/wiki/Methyl_isocyanide
Pyrrolidonyl-β-naphthylamidePyrrolidonyl-β-naphthylamide
PicralinalPicralinal
Heterocyclic compounds with 6 rings, All stub articles, Alkaloid stubs). ...
https://en.wikipedia.org/wiki/Picralinal
DPEphosDPEphos
"New Diphosphine Ligands Based on Heterocyclic Aromatics Inducing Very High Regioselectivity in Rhodium-Catalyzed ... Phenyl compounds). ...
https://en.wikipedia.org/wiki/DPEphos
SibiricineSibiricine
Heterocyclic compounds with 3 rings, Nitrogen heterocycles, Oxygen heterocycles, Spiro compounds). ... CID 632652 from PubChem (PubChem ID (CID) same as Wikidata, Chemical articles with multiple compound IDs, Chemicals using ...
https://en.wikipedia.org/wiki/Sibiricine
Intramolecular Heck reactionIntramolecular Heck reaction
The reaction may be used to produce carbocyclic or heterocyclic organic compounds with a variety of ring sizes. Chiral ... The high stability of Heck reaction catalysts permits the synthesis of highly strained compounds at elevated temperatures. In ...
https://en.wikipedia.org/wiki/Intramolecular_Heck_reaction
DianhydrohexitolsDianhydrohexitols
... are heterocyclic compounds with the formula [OCH2CH(OH)CH]2. These diols are colorless solids that are ... v t e (Diols, Furofurans, All stub articles, Heterocyclic compound stubs). ...
https://en.wikipedia.org/wiki/Dianhydrohexitols
Sonogashira couplingSonogashira coupling
N-heterocyclic carbenes (NHCs) have become one of the most important ligands in transition-metal catalysis. The success of ... The versatility of the Sonogashira reaction makes it a widely used reaction in the synthesis of a variety of compounds. One ... In an inverse Sonogashira coupling the reactants are an aryl or vinyl compound and an alkynyl halide. In some cases ... The 1,3-enyne moiety is an important structural unit for biologically active and natural compounds.[citation needed] It can be ...
https://en.wikipedia.org/wiki/Sonogashira_coupling
DarienineDarienine
Heterocyclic compounds with 3 rings, Nitrogen heterocycles, Methoxy compounds, Ketones, All stub articles, Alkaloid stubs). ...
https://en.wikipedia.org/wiki/Darienine
Albert MeyersAlbert Meyers
For his work in the area of synthetic organic chemistry, particularly in synthesis of heterocyclic compounds, Meyers was ...
https://en.wikipedia.org/wiki/Albert_Meyers
Maralixibat chlorideMaralixibat chloride
Heterocyclic compounds with 2 rings, Sulfur heterocycles, Nitrogen heterocycles, Quaternary ammonium compounds, Tertiary amines ...
https://en.wikipedia.org/wiki/Maralixibat_chloride
DioxazoloneDioxazolone
It is an uncommon heterocyclic compound. They arise by the phosgenation of hydroxamic acids: RC(O)NHOH + COCl2 → RC=NO2CO + 2 ... Middleton, William J. (1983). "1,3,4-Dioxazol-2-ones: a potentially hazardous class of compounds". Journal of Organic Chemistry ...
https://en.wikipedia.org/wiki/Dioxazolone
Pi-interactionPi-interaction
S-Adenosyl methionine (SAM) can act as a catalyst for the transfer of methyl group from the sulfonium compound to nucleophile. ... N-heterocyclic carbene) Ligands Containing [Ni2(μ-OH)] Cores as Highly Efficient Catalysts for the Coupling of Aryl Chlorides ... These interactions are commonly referred to as sandwich compounds. Specific research Due to reasons explained earlier in the ...
https://en.wikipedia.org/wiki/Pi-interaction
Index of biochemistry articlesIndex of biochemistry articles
... heterocyclic compound - heterotroph - heterozygote - Hfr cell - Hill reaction - His tag - histamine H1 receptor - histamine H2 ... alicyclic compound - aliphatic compound - alkali - allosteric site - allostery - allotrope - allotropy - alpha adrenergic ... list of compounds - list of gene families - locus - luminescent protein - lymphocyte homing receptor - lysine - lysis - lysis ... organic compound - organic nomenclature - organic reaction - organism - osmosis - osteocalcin - outer hair cell - outline of ...
https://en.wikipedia.org/wiki/Index_of_biochemistry_articles
2023 Heterocyclic Compounds Conference GRC2023 Heterocyclic Compounds Conference GRC
The 2023 Gordon Research Conference on Heterocyclic Compounds will be held in Newport, RI. Apply today to reserve your spot. ... The Heterocyclic Compounds GRC is a premier, international scientific conference focused on advancing the frontiers of science ... Heterocyclic compounds are fundamental to catalysis, synthesis, natural products, materials, biology, medicine, and beyond, and ... From a foundation of heterocyclic compounds, scientists forge solutions to benefit humans and to expand human knowledge. As one ...
https://www.grc.org/heterocyclic-compounds-conference/2023/
EP2455376A1 - Heterocyclic compounds as inhibitors of hepatitis C virus (HCV) - Google Patents
This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using ... Compounds effective in inhibiting replication of Hepatitis C virus (HCV) are described. ... EP2455376A1 - Heterocyclic compounds as inhibitors of hepatitis C virus (HCV) - Google Patents. Heterocyclic compounds as ... 150000002391 heterocyclic compounds Chemical class 0.000 title 1 * 150000001875 compounds Chemical class 0.000 claims abstract ...
https://patents.google.com/patent/EP2455376A1/en
2932.19.10 - Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, containing an unfused furan ring, nesoi - United...2932.19.10 - Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, containing an unfused furan ring, nesoi - United...
Description: Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, containing an unfused furan ring, nesoi MFN Duty ... Next Tariff (2932.19.50 - Nonaromatic heterocyclic compounds with oxygen hetero-atom(s) only, containing an unfused furan ring ... Next Tariff (2932.19.50 - Nonaromatic heterocyclic compounds with oxygen hetero-atom(s) only, containing an unfused furan ring ...
http://www.faqs.org/rulings/tariffs/29321910.html
British Library EThOS: Novel one-pot multi-reaction methods for the synthesis of carbocyclic and heterocyclic compoundsBritish Library EThOS: Novel one-pot multi-reaction methods for the synthesis of carbocyclic and heterocyclic compounds
Novel one-pot multi-reaction methods for the synthesis of carbocyclic and heterocyclic compounds ... including a series of biologically active compounds. ...
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.788798
The Chemistry of Heterocyclic Compounds, Condensed Imidazoles, 5-5 Ring Systems | Ebook | Ellibs EbookstoreThe Chemistry of Heterocyclic Compounds, Condensed Imidazoles, 5-5 Ring Systems | Ebook | Ellibs Ebookstore
The Chemistry of Heterocyclic Compounds, Condensed Imidazoles, 5-5 Ring Systems - Author: Preston, P. N. - Price: 422,40€ ... The Chemistry of Heterocyclic Compounds, Six Membered Heterocyclic Nitrogen Compounds with Three Condensed Rings. Allen, C. F. ... The Chemistry of Heterocyclic Compounds, Benzimidazoles and Cogeneric Tricyclic Compounds. Preston, P. N. ... The Chemistry of Heterocyclic Compounds, Benzimdazoles and Cogeneric Tricyclic Compounds. Preston, P. N. ...
https://www.ellibs.com/book/9780470188811/the-chemistry-of-heterocyclic-compounds-condensed-imidazoles-5-5-ring-systems
HKU Scholars Hub: Anticancer Gold(III) Compounds With Porphyrin or N-heterocyclic Carbene LigandsHKU Scholars Hub: Anticancer Gold(III) Compounds With Porphyrin or N-heterocyclic Carbene Ligands
Article: Anticancer Gold(III) Compounds With Porphyrin or N-heterocyclic Carbene Ligands. *Show simple item record ... Coordination ligands containing C and/or N donor atom(s) such as porphyrin, pincer-type cyclometalated and/or N-heterocyclic ... In this review, we described our recent work on the anticancer properties of gold(III) compounds and the identification of ... Coordination ligands containing C and/or N donor atom(s) such as porphyrin, pincer-type cyclometalated and/or N-heterocyclic ...
https://hub.hku.hk/handle/10722/302371
Heterocyclic Compounds, Bridged-Ring | Colorado PROFILES
"Heterocyclic Compounds, Bridged-Ring" by people in this website by year, and whether "Heterocyclic Compounds, Bridged-Ring" was ... "Heterocyclic Compounds, Bridged-Ring" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... Below are the most recent publications written about "Heterocyclic Compounds, Bridged-Ring" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Heterocyclic Compounds, Bridged-Ring". ...
https://profiles.ucdenver.edu/display/206105
MODIP - Aristotle University of Thessaloniki | Chemistry of Heterocyclic CompoundsMODIP - Aristotle University of Thessaloniki | Chemistry of Heterocyclic Compounds
ΧΗΜΕΙΑ ΕΤΕΡΟΚΥΚΛΙΚΩΝ ΕΝΩΣΕΩΝ / Chemistry of Heterocyclic ...
https://qa.auth.gr/fr/class/1/600062385
Solid-phase organic synthesis of heterocyclic compounds - Fingerprint - Okayama University
Dive into the research topics of Solid-phase organic synthesis of heterocyclic compounds. Together they form a unique ...
https://okayama.pure.elsevier.com/en/publications/solid-phase-organic-synthesis-of-heterocyclic-compounds/fingerprints/
Results of search for 'su:{Heterocyclic compounds}' › WHO HQ Library catalog
Certain polycyclic aromatic hydrocarbons and heterocyclic compounds / this publication is the outcome of the meeting of the ... Bitumens and bitumen emissions, and some n- and s-heterocyclic polycyclic aromatic hydrocarbons by International Agency for ...
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Treatment of Nitrogen Heterocyclic Compounds (NHCs) in Coking Wastewater by White-Rot Fungi | Tecnología y ciencias del...Treatment of Nitrogen Heterocyclic Compounds (NHCs) in Coking Wastewater by White-Rot Fungi | Tecnología y ciencias del...
Treatment of Nitrogen Heterocyclic Compounds (NHCs) in Coking Wastewater by White-Rot Fungi Autores/as. * Chaofan Huang College ... White-rot fungi, Coking wastewater, Nitrogen heterocyclic compounds, Co-substrate, Laccase Resumen. In the present study the ... Huang, C., Ren, D., Kang, C., Deng, Z., Guo, H., Zhang, S., & Zhang, X. (2019). Treatment of Nitrogen Heterocyclic Compounds ( ... mechanism of action of white-rot fungi on nitrogen heterocyclic compounds, changes of enzyme activity and white-rot fungi ...
http://www.revistatyca.org.mx/ojs/index.php/tyca/article/view/2021
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Aniruddha Deb - Inorganic Heterocyclic compoundsAniruddha Deb - Inorganic Heterocyclic compounds
Inorganic Heterocyclic compounds. Posted on Sun 03 May 2020 in Chemistry The 45th IChO preparatory problem list had this as ... Thus, the formula of the compound is $\ce{(NSOCl)3}$. This compound has been synthesized and its name is sulphanuric chloride ... Lets try getting some values for x,y,z and a. If we let all of them be 1, then the compound becomes $\ce{(SO(Cl)N)3}$. We can ... This structure has been proposed keeping in mind the physical properties of the compound. ...
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Heterocyclic compounds - Catalog - LiMac ScienceHeterocyclic compounds - Catalog - LiMac Science
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Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds<...Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds<...
Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds. ... Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds. ... Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds. ... Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds. ...
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IMSEAR at SEARO: Antifeedant activity of some new heterocyclic compounds against the larvae of Spodoptera litura F.
Antifeedant activity of some new heterocyclic compounds against the larvae of Spodoptera litura F. Indian Journal of ... Antifeedant activity of some new heterocyclic compounds against the larvae of Spodoptera litura F. ...
https://imsear.searo.who.int/handle/123456789/56250
SPIROPYRANS: MOLECULES IN MOTION | Козленко | Chemistry of Heterocyclic CompoundsSPIROPYRANS: MOLECULES IN MOTION | Козленко | Chemistry of Heterocyclic Compounds
Upadacitinib as monotherapy and in combination with non-biologic disease-modifying antirheumatic drugs for psoriatic arthritisUpadacitinib as monotherapy and in combination with non-biologic disease-modifying antirheumatic drugs for psoriatic arthritis
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Heterocyclic Acids < Heterocyclic Compounds << Cyclic Compounds <<< Molecules @...
Heterocyclic Acids are a class of acids containing a ring structure in which at least one atom other than carbon is ... Heterocyclic Acids ⌊Alchemy Center. ⌊Atoms. ⌊Polyatomic entities. ⌊Molecules. ⌊Cyclic Compounds. ⌊Heterocyclic Compounds. ⌊ ... Heterocyclic Acids "Heterocyclic Acids" In organic chemistry, Heterocyclic Acids are a class of acids containing a ring ... In chemistry, Picolinic Acid, a heterocyclic acid compound and an isomer of nicotinic acid, is a pyridine compound with a ...
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Succinimides | Harvard Catalyst Profiles | Harvard CatalystSuccinimides | Harvard Catalyst Profiles | Harvard Catalyst
Heterocyclic Compounds [D03]. *Heterocyclic Compounds, 1-Ring [D03.383]. *Pyrrolidines [D03.383.773]. *Pyrrolidinones [D03.383. ... They are sweet-tasting compounds that are used as chemical intermediates and plant growth stimulants. ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Succinimides
New heterocyclic compounds useful for treating e.g. diabetes, obesity, hypertension, glaucoma, arthritis, asthma, osteoporosis,...New heterocyclic compounds useful for treating e.g. diabetes, obesity, hypertension, glaucoma, arthritis, asthma, osteoporosis,...
New heterocyclic compounds useful for treating e.g. diabetes, obesity, hypertension, glaucoma, arthritis, asthma, osteoporosis ... New heterocyclic compounds useful for treating e.g. diabetes, obesity, hypertension, glaucoma, arthritis, asthma, osteoporosis ...
https://www.pharm.ox.ac.uk/publications/682487
2932: Heterocyclic compounds with oxygen hetero-atom(s) onl - All That Stats2932: Heterocyclic compounds with oxygen hetero-atom(s) onl - All That Stats
... organo-inorganic compounds, nes 293100 organo-inorganic compounds, nes 2932 Heterocyclic compounds with oxygen hetero-atom(s) ... Heterocyclic compounds, nes 293410 Heterocyclic compounds containg an unfusd thiazole rg in the structur 293420 Heterocycl ... nes and their compounds 284510 Heavy water (deuterium oxide) 284590 Isotopes nes and their compounds 2846 Compounds of rare- ... 292690 Nitrile-function compounds, nes 2927 Diazo-, azoor azoxy-compounds 292700 Diazo-, azoor azoxy-compounds 2928 organic ...
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Chemistry Of Heterocyclic Compounds: Thiophene And Its Derivatives, Part Three, Volume 44
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Candida albicans biofilm effect of novel heterocyclic compounds. J. Antimicrob. Chemother. 2014, 69, 416-427. [Google Scholar ... Natural and quorum sensing compounds, such as marine compounds, essential oils (EOs), and extracts, have also been analyzed. ... This compound also exposed antibiofilm activity against C. albicans and mixed cultures of C. albicans-A. baumannii. After a ... It was concluded that EntV, or an analogous compound, should be explored as a therapeutic alternative, alone or in combination ...
https://www.mdpi.com/2309-608X/6/1/5
ChemistryDerivativesPolycyclic CompoundsBiologically active compoundsAminesSubstancesHydrocarbonsSynthesisThiopheneDrugsNitrogenHumansCarbeneMoleculesChemicalAntiviralMonomersAcidAnticancerTerpenoidsReactionsBiologicalTherapeuticDrug DiscoveryBiologyMeSHGroup
Chemistry27
  • In organic chemistry , Heterocyclic Acids are a class of acids containing a ring structure in which at least one atom other than carbon (C) is incorporated. (wellnessadvantage.com)
  • In chemistry, Isonicotinic Acids are heterocyclic acids that are derivatives of 4-pyridinecarboxylic acid (isonicotinic acid). (wellnessadvantage.com)
  • In chemistry, Picolinic Acid , a heterocyclic acid compound and an isomer of nicotinic acid, is a pyridine compound with a carboxyl side chain at the 2-position. (wellnessadvantage.com)
  • In chemistry , the heterocyclic indole compounds , Indoleacetic Acids are acetic acid derivatives. (wellnessadvantage.com)
  • In organic chemistry , Isonipecotic Acid is a heterocyclic compound , consisting of a piperidine ring with a carboxylic acid moiety in the iso position, which act as a GABAA receptor partial agonist. (wellnessadvantage.com)
  • A Much Chemistry of Heterocyclic girl 's that the most s metricsRESULTSView for play pages has that which is the peer-reviewed cases and People of text, back than Following downloading in an inherited INTRODUCTION. (reparierladen.de)
  • When you appreciate on a Technical Chemistry of Heterocyclic Compounds: Thiophene and F, you will ok aligned to an Amazon 9tailsfox professor where you can drill more about the card and Sign it. (reparierladen.de)
  • Chemistry of Heterocyclic Compounds: Thiophene and its Derivatives, Part Three, end employees: new l level has a Elizabethan administration g that should develop at a jealous site contact in your people. (reparierladen.de)
  • From 2003 to 2005, he was as the hard Chemistry of Heterocyclic Compounds: Thiophene and its Derivatives, Part Three, of the Center for USA-Studies at the Leucorea in Wittenberg. (reparierladen.de)
  • 1818014, ' Chemistry of Heterocyclic Compounds: Thiophene and its Derivatives, ': ' Please complete Instead your g is next. (reparierladen.de)
  • At Chemistry of Heterocyclic Compounds: Thiophene and its Derivatives, Part Three, had the Asian species of the welcome campus: if the systems loved or examined steamed, the ancient transition to study the Taliban did even found. (reparierladen.de)
  • In organic chemistry, Thiepanes are a class of organic compounds in the organoheterocyclic compound superclass , containing a heptane ring (seven-membered ring heterocycles) in which one of the carbon atoms is replaced by a sulfur atom (S) . (wellnessadvocate.com)
  • The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. (ergodebooks.com)
  • With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists. (ergodebooks.com)
  • Green chemistry}, abstract = { The catalytic efficiency of silver nanoparticles supported on chitosan as a green, robust, and efficient nanocatalyst for the direct synthesis of biologically active compounds, such as: imidazole derivatives as well as pyrazine scaffolds through multi-component reactions strategy, have been demonstrated. (undip.ac.id)
  • The fourth Springer Heterocyclic Chemistry Award will be presented to Chris Vanderwal, Professor of Chemistry and of Pharmaceutical Sciences at the University of California, Irvine. (springer.com)
  • The award will be presented at the European Colloquium on Heterocyclic Chemistry in Rouen, France, from 25 to 28 August 2020. (springer.com)
  • His research has been recognized with numerous awards including an ACS A. C. Cope Scholar Award and the A. R. Katritzky Junior Award in Heterocyclic Chemistry in 2017. (springer.com)
  • Chris Vanderwal said: "I am honoured to have been chosen as the 2020 Springer Heterocyclic Chemistry Award winner, and to be added to the list that includes Profs. (springer.com)
  • I relish the opportunity to meet and interact with my European colleagues in heterocyclic chemistry at the ECHC meeting in Rouen. (springer.com)
  • The Springer Heterocyclic Chemistry Award was created by Springer and the series editors of the book review series Topics in Heterocyclic Chemistry. (springer.com)
  • The award is presented every two to three years to an outstanding independent academic researcher working in the field of heterocyclic chemistry. (springer.com)
  • All aspects of heterocyclic chemistry, including experimental and theoretical work, are eligible. (springer.com)
  • Heterocyclic chemistry makes up an important part of our organic chemistry publication programme at Springer, and it is therefore our pleasure to acknowledge Chris Vanderwal's highly creative research in this field through the Springer Heterocyclic Chemistry Award 2020," said Charlotte Hollingworth, executive editor at Springer. (springer.com)
  • The award winner receives a travel grant to attend the European Colloquium on Heterocyclic Chemistry (ECHC), at which he or she holds a special lecture. (springer.com)
  • In addition, there is a €1,000 cash prize and a lifelong online subscription to Topics in Heterocyclic Chemistry. (springer.com)
  • The first of these introduces the allenic functionality highlighting the special properties associated with allenic compounds and the recent advances in allene chemistry with particular emphasis on the application of allenic substrates to heterocyclisation, carbocyclisation and carbometallation. (ucl.ac.uk)
Derivatives2
  • Coordination compounds with heterocyclic ester derivatives. (bvsalud.org)
  • This compound belongs to the class of organic compounds known as tetrahydrofolic acids and derivatives. (drugbank.com)
Polycyclic Compounds1
  • Investigations into the use of the intramolecular Diels-Alder furan cycloaddition (IMDAF) reaction for synthesis of complex polycyclic compounds were carried out. (hud.ac.uk)
Biologically active compounds2
  • The third section describes a one-pot diazotisation-intramolecular cyclisation process for the synthesis of 1H-benzotriazoles and the regioselective preparation of N1-substituted benzotriazoles, including a series of biologically active compounds. (bl.uk)
  • Phytochemicals are biologically active compounds found in plants which reduce inflammation and oxidative damage that spark cancer growth. (nutriformance.com)
Amines5
  • Matching to Harvard Well being Building , you wish to keep away from uncovering the steak to heterocyclic amines, compounds form when the fats drips low and brings about the hearth to appear and light up with the grilling. (motefakeranaria.com)
  • The high heat and flame with either a charcoal or gas grill can increase your exposure to chemical compounds like AGEs, (advanced glycation end products) HCAs, (heterocyclic amines), and PAHs (polycyclic hydrocarbons) which are known as "carcinogens", a chemical compound that may contribute to an increased risk of cancer if inhaled or consumed. (nutritionwithsusan.com)
  • Cooking meat at high temperatures while grilling, boiling, and frying over an open flame creates 2 cancer-causing substances such as "heterocyclic amines" (HCAs) and "polycyclic aromatic hydrocarbons" (PAHs). (nutriformance.com)
  • Nitrates are reduced to nitrites and can react with amines to form N-nitrosamine compounds. (cdc.gov)
  • IARC Monographs, volume 56: some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins - summary of data reported and evaluation. (bvsalud.org)
Substances1
  • Analysis of organic trace compounds in the atmosphere and the correlation between meteorological situation and concentration of reference substances. (cdc.gov)
Hydrocarbons3
  • Certain polycyclic aromatic hydrocarbons and heterocyclic compounds / this publication is the outcome of the meeting of the IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man, Lyon, 5-11 December 1972. (who.int)
  • Asphalt is a complex mixture of paraffinic and aromatic hydrocarbons and heterocyclic compounds. (cdc.gov)
  • Asphalt fume is a complex mixture of aliphatic and aromatic hydrocarbons, cyclic alkanes, and heterocyclic compounds containing S, N, or O. Irritation has been reported and low levels of possible carcinogenic polycyclic aromatic compounds (PAC) are present in asphalt fume. (cdc.gov)
Synthesis4
  • As one of the longest-running Gordon Research Conferences, the 2023 Heterocyclic Compounds GRC will continue to provide a platform for disclosures of new strategies for the discovery, synthesis, incorporation, and application of powerful heterocycles. (grc.org)
  • Chris Vanderwal's research mainly focuses on the chemical synthesis of complex, bioactive natural products, including alkaloids, terpenoids, and polyhalogenated compounds. (springer.com)
  • His group is currently working on compounds with antibacterial, antiviral, antimalarial, anticancer, and immunosuppressive activities, with the ultimate goal of using the tools of chemical synthesis to better understand their mechanisms of action. (springer.com)
  • This thesis describes the development of novel tandem reactions of allenic substrates, designed for the synthesis of structurally complex heterocyclic and carbocyclic systems together with the development of methodology for stereocontrolled preparation of functionalised olefins. (ucl.ac.uk)
Thiophene1
  • Buy Heterocyclic compound, Thiophene compounds, INORGANIC & ORGANIC CHEMICALS Product on Baoji GuoKang Bio-Technology Co., Ltd. (gk-bio.com)
Drugs3
  • Once inside the body, thiopurine drugs are converted to toxic compounds that kill immune system cells in the bone marrow. (medlineplus.gov)
  • The TPMT enzyme "turns off" thiopurine drugs by metabolizing them to inactive, nontoxic compounds. (medlineplus.gov)
  • Without enough of this enzyme, the body cannot "turn off" thiopurine drugs by metabolizing them into inactive compounds. (medlineplus.gov)
Nitrogen4
  • In the present study the white-rot fungi BP was selected to study the degradation of nitrogen heterocyclic compounds in real and simulated coking wastewater. (revistatyca.org.mx)
  • The study incorporated analysis of the degradation process, mechanism of action of white-rot fungi on nitrogen heterocyclic compounds, changes of enzyme activity and white-rot fungi biomass growth rate in coking wastewater (simulated and actual). (revistatyca.org.mx)
  • Reversing this reaction towards carbon-nitrogen bond formation can be a powerful approach to prepare valuable compounds that could find applications in everyday life. (rug.nl)
  • It is a cage compound with three ethyl groups attached to two nitrogen atoms. (polygsy.com)
Humans3
  • From a foundation of heterocyclic compounds, scientists forge solutions to benefit humans and to expand human knowledge. (grc.org)
  • It presents data reported and results of carcinogenicity evaluation for humans and animals of some chemical compounds. (bvsalud.org)
  • It presents data reported and results of carcinogenicity evaluation for humans and animals of printing processes and inks, carbon black and some nitro compounds. (bvsalud.org)
Carbene2
  • Coordination ligands containing C and/or N donor atom(s) such as porphyrin, pincer-type cyclometalated and/or N-heterocyclic carbene (NHC) can be employed to stabilize gold(III) ion for the preparation of anticancer active compounds. (hku.hk)
  • 75. N-Heterocyclic Carbene-Catalyzed Formal [6+2] Annulation Reaction via Cross-Conjugated Aza-Trienolate Intermediates. (insa-rouen.fr)
Molecules2
  • This enzyme carries out a specific chemical reaction called S-methylation of a group of molecules known as aromatic and heterocyclic sulphydryl compounds. (medlineplus.gov)
  • The molecules at the heart of this proposal are cyclic compounds (called heterocyclic compounds), which are widespread materials with a variety of useful properties. (ukri.org)
Chemical2
  • We also summarized the chemical formulation strategies that have been adopted for the delivery of cytotoxic gold compounds, and for ameliorating the in vivo toxicity. (hku.hk)
  • They are sweet-tasting compounds that are used as chemical intermediates and plant growth stimulants. (harvard.edu)
Antiviral1
  • A molecular modelling approach for identifying antiviral selenium-containing heterocyclic compounds that inhibit the main protease of SARS-CoV-2: an in silico investigation. (cdc.gov)
Monomers1
  • It has been demonstrated that most of these polymers can be prepared by oxidative methods, electrodeposition, and metal-catalyzed coupling reactions of the aromatic and heterocyclic monomers. (elsevier.com)
Acid3
  • Orotic Acid (Pyrimidinecarboxylic Acid) is a heterocyclic compound and an acid. (wellnessadvantage.com)
  • Phytotoxic activity in Flourensia campestris and isolation of (--)-hamanasic acid A as its active principle compound. (semanticscholar.org)
  • Compounds 2a-2h and 3a-3h were obtained in 55% - 90% yield after briefly maintaining equimolar quantities of 2-mercaptobenzoic acid hydrazide 1 and the appropriate aldehyde during 10 - 15 min in methanol solution at room temperature (Experimental part). (scirp.org)
Anticancer1
  • In this review, we described our recent work on the anticancer properties of gold(III) compounds and the identification of molecular targets involved in the mechanisms of action. (hku.hk)
Terpenoids1
  • Bioactive terpenoids 1 and 2 along with a known compound, β-sitosterol, have been isolated from the DCM extract of the fruits of Lagerstroemia speciosa. (usda.gov)
Reactions1
  • New and smarter ways of making these important compounds is a useful goal because it enables reactions to be run faster, cleaner and with less waste- this is a good thing for industry and for the environment. (ukri.org)
Biological1
  • The complex interactions leading to a wide range of biological activity can be probed, enhanced, and harnessed through heterocyclic compounds. (grc.org)
Therapeutic1
  • Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis. (cdc.gov)
Drug Discovery1
  • At each step of the drug discovery process, API or target compounds have to be isolated, purified and filtered prior to analysis. (silicycle.com)
Biology1
  • Antifeedant activity of some new heterocyclic compounds against the larvae of Spodoptera litura F. Indian Journal of Experimental Biology. (who.int)
MeSH1
  • Heterocyclic Compounds, Bridged-Ring" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Group1
  • Plant products form a very large group of natural products including compounds from the animal kingdom. (cbspd.co.in)
JoF | Free Full-Text | Candida spp./Bacteria Mixed Biofilms
JoF | Free Full-Text | Candida spp./Bacteria Mixed Biofilms (mdpi.com)
SYNTHESIS OF ANABASINE-CONTAINING AMINOMETHYL DERIVATIVES OF 6-HYDROXYAURONES | Попова | Chemistry of Heterocyclic Compounds
SYNTHESIS OF ANABASINE-CONTAINING AMINOMETHYL DERIVATIVES OF 6-HYDROXYAURONES | Попова | Chemistry of Heterocyclic Compounds (hgs.osi.lv)
SYNTHESIS AND OXIDATION OF ALL ISOMERIC 2-(PYRAZOLYL)ETHANOLS | Ivonin | Chemistry of Heterocyclic Compounds
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I|N|/i|-3,3,3-TRIFLUOROPROPENYL DERIVATIVES OF AZOLES | Петко | Chemistry of Heterocyclic Compounds
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2-propyl-1H-imidazole-4,5-dicarboxy acid 58954-23-7, China 2-propyl-1H-imidazole-4,5-dicarboxy acid 58954-23-7 Manufacturers,...
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2-YLIDENE-1,3-THIAZOLIDINES AND THEIR NONHYDROGENATED ANALOGS: METHODS OF SYNTHESIS AND CHEMICAL PROPERTIES | Литвинчук |...
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Laboratory Evaluations of Lepidopteran-Active Soybean Seed Treatments on Survivorship of Fall Armyworm (Lepidoptera: Noctuidae)...
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Israpafant (CHEBI:31736)
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The Chemistry of Heterocyclic Compounds, Condensed Imidazoles, 5-5 Ring Systems | Ebook | Ellibs Ebookstore
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Find Research outputs - Heriot-Watt Research Portal
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Hansen, Jørn H | UiT
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Prazepam | Harvard Catalyst Profiles | Harvard Catalyst
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Heteroarene - Ontology Report - Rat Genome Database
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Construction of catalytically proficient enzymes from de novo designed proteins - University of Bristol
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Pyrazole Definition & Meaning | Merriam-Webster Medical
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Alcatrão de hulha - Wikipédia, a enciclopédia livre
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MeSH Coming Attractions. NLM Technical Bulletin. Sep-Oct 1998
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Molecules | February 2017 - Browse Articles
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CN106456573 Novel functionalized 1,3-benzene diols for the treatment of hepatic encephalopathy and their method of use
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