Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
Inorganic compounds that contain nitrogen as an integral part of the molecule.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
A class of organic compounds containing four or more ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
A class of organic compounds containing three ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.
Carboxylic acids that have a homocyclic ring structure in which all the ring atoms are carbon.
The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.
A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.
Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.
A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.
Compounds with two peroxide groups, that is, two pairs of adjacent OXYGEN atoms. They may have activity against PLASMODIUM similar to the ARTEMISININS.
Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Substances that reduce the growth or reproduction of BACTERIA.

Comparison of ultrasmall particles of iron oxide (USPIO)-enhanced T2-weighted, conventional T2-weighted, and gadolinium-enhanced T1-weighted MR images in rats with experimental autoimmune encephalomyelitis. (1/1106)

BACKGROUND AND PURPOSE: Ultrasmall particles of iron oxide (USPIO) constitute a contrast agent that accumulates in cells from the mononuclear phagocytic system. In the CNS they may accumulate in phagocytic cells such as macrophages. The goal of this study was to compare USPIO-enhanced MR images with conventional T2-weighted images and gadolinium-enhanced T1-weighted images in a model of experimental autoimmune encephalomyelitis (EAE). METHODS: Nine rats with EAE and four control rats were imaged at 4.7 T and 1.5 T with conventional T1- and T2-weighted sequences, gadolinium-enhanced T1-weighted sequences, and T2-weighted sequences obtained 24 hours after intravenous injection of a USPIO contrast agent, AMI-227. Histologic examination was performed with hematoxylin-eosin stain, Perls' stain for iron, and ED1 immunohistochemistry for macrophages. RESULTS: USPIO-enhanced images showed a high sensitivity (8/9) for detecting EAE lesions, whereas poor sensitivity was obtained with T2-weighted images (1/9) and gadolinium-enhanced T1-weighted images (0/9). All the MR findings in the control rats were negative. Histologic examination revealed the presence of macrophages at the site where abnormalities were seen on USPIO-enhanced images. CONCLUSION: The high sensitivity of USPIO for macrophage activity relative to other imaging techniques is explained by the histologic findings of numerous perivascular cell infiltrates, including macrophages, in EAE. This work supports the possibility of intracellular USPIO transport to the CNS by monocytes/macrophages, which may have future implications for imaging of human inflammatory diseases.  (+info)

67Cu-versus 131I-labeled Lym-1 antibody: comparative pharmacokinetics and dosimetry in patients with non-Hodgkin's lymphoma. (2/1106)

Antilymphoma mouse monoclonal antibody (MoAb) Lym-1, labeled with 67Cu or 131I, has demonstrated promising results in radioimmunotherapy (RIT) for lymphoma. Although 131I has played a central role in RIT thus far, some properties of 67Cu are preferable. A subset of our patients received both 67Cu- and 131I-labeled Lym-1, allowing a comparative evaluation of the two radiopharmaceuticals administered to a matched population of patients. Four patients with B-lymphocytic non-Hodgkin's lymphoma that had progressed despite standard therapy entered trials of 67Cu- and 131I-labeled Lym-1, which were injected 3-26 days apart. Lym-1 was conjugated to 6-[p-(bromoacetamido)benzyl]-1,4,7,11-tetraazacyclotetradecane-N,N ',N",N'"-tetraacetic acid (BAT) via 2-iminothiolane (2IT) and radiolabeled with 67Cu to prepare 67Cu-2IT-BAT-Lym-1; 131I-Lym-1 was preparred by the chloramine-T reaction. Planar imaging was used to quantitate 67Cu-2IT-BAT-Lym-1 or 131I-Lym-1 in organs and tumors daily for 3 days or longer. 67Cu-2IT-BAT-Lym-1 exhibited higher peak concentration in 92% (12 of 13) of tumors and a longer biological half-time in every tumor than 131I-Lym-1. The mean tumor concentration (%ID/g) of 67Cu-2IT-BAT-Lym-1 was 1.7, 2.2, and 2.8 times that of 131I-Lym-1 at 0, 24, and 48 h after injection, respectively. The mean biological half-times of 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 in tumor were 8.8 and 2.3 days, respectively. Consequently, the mean tumor radiation dose delivered by 67Cu-2IT-BAT-Lym-1 was twice that of 131I-Lym-1, 2.8 (range 0.8-6.7), and 1.4 (range 0.4-35) Gy/GBq, respectively. 67Cu-2IT-BAT-Lym-1 delivered a lower marrow radiation dose than 131I-Lym-1; hence, the tumor:marrow therapeutic indices were 29 and 9.7, respectively. Radiation doses from 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 to normal tissues were similar except for liver, which received a higher dose from 67Cu-2IT-BAT-Lym-1. Images obtained with 67Cu-2IT-BAT-Lym-1 were superior. Radiation dosimetry data for 67Cu-2IT-BAT-Lym-1 and 131I-Lym-1 agreed with corresponding data from the larger populations of patients from which the matched population for the current study was drawn. In conclusion, 67Cu-2IT-BAT-Lym-1 given to non-Hodgkin's lymphoma patients in close temporal proximity to 131I-Lym-1 exhibited greater uptake and longer retention in tumor, resulting in higher radiation dose and therapeutic index than 131I-Lym-1. These as well as other factors suggest that 67Cu-2IT-BAT-Lym-1 may be superior to 131I-Lym-1 for RIT.  (+info)

Efficacy of RD3-0028 aerosol treatment against respiratory syncytial virus infection in immunosuppressed mice. (3/1106)

RD3-0028, a benzodithiin compound, has antiviral activity against respiratory syncytial virus (RSV) in cell culture. We used a mouse model of RSV infection to determine the in vivo effect of RD3-0028. Cyclophosphamide (CYP)-treated, immunosuppressed mice were inoculated intranasally. The lungs of the mice were removed on day 4. The virus titers of the lungs of RD3-0028-treated mice were compared to the virus titers of the lungs of virus-inoculated, untreated control mice. In an effort to increase the therapeutic effectiveness of this compound, RD3-0028 was administered by aerosol to RSV-infected mice by using a head-exposure system. Aerosols generated from reservoirs containing RD3-0028 (7 mg/ml) administered for 2 h twice daily for 3 days significantly reduced the pulmonary titer of RSV-infected mice. It is clear that the minimal effective dose of RD3-0028 for RSV-infected mice is significantly less than that of ribavirin, the only compound currently available for use against RSV disease. Furthermore, the RD3-0028 aerosol administration appeared to protect the lungs of infected, CYP-treated mice against tissue damage, as evidenced by the preservation of the lung architecture and a reduction in pulmonary inflammatory infiltrates. RD3-0028 aerosol was not toxic for mice at the therapeutic dose. The present study demonstrates the effectiveness of aerosol administration of RD3-0028 for RSV-infected mice.  (+info)

Cancer chemopreventive mechanisms of tea against heterocyclic amine mutagens from cooked meat. (4/1106)

Cooking meat and fish under normal conditions produces heterocyclic amine mutagens, several of which have been shown to induce colon tumors in experimental animals. In our search for natural dietary components that might protect against these mutagens, it was found that green tea and black tea inhibit the formation of heterocyclic amine-induced colonic aberrant crypt foci (ACF) in the rat. Since ACF are considered to be putative preneoplastic lesions, we examined the inhibitory mechanisms of tea against the heterocyclic amines. In the initial studies using the Salmonella mutagenicity assay, green tea and black tea inhibited according to the concentration of tea leaves during brewing and the time of brewing; a 2-3-min brew of 5% green tea (w/v) was sufficient for >90% antimutagenic activity. N-hydroxylated heterocyclic amines, which are direct-acting mutagens in Salmonella, were inhibited by complete tea beverage and by individual components of tea, such as epigallocatechin-3-gallate (EGCG). Inhibition did not involve enhanced mutagen degradation, and EGCG and other catechins complexed only weakly with the mutagens, suggesting electrophile scavenging as an alternative mechanism. Enzymes that contribute to the metabolic activation of heterocyclic amines, namely microsomal NADPH-cytochrome P450 reductase and N, O-acetyltransferase, were inhibited by tea in vitro. Studies in vivo established that tea also induces cytochromes P450 and Phase II enzymes in a manner consistent with the rapid metabolism and excretion of heterocyclic amines. Collectively, the results indicate that tea possesses anticarcinogenic activity in the colon, and this most likely involves multiple inhibitory mechanisms.  (+info)

The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA. (5/1106)

In a screen for mutants that display synthetic lethal interaction with hpr1Delta, a hyperrecombination mutant of Saccharomyces cerevisiae, we have isolated a novel cold-sensitive allele of the acetyl coenzyme A (CoA) carboxylase gene, acc1(cs), encoding the rate-limiting enzyme of fatty acid synthesis. The synthetic lethal phenotype of the acc1(cs) hpr1Delta double mutant was only partially complemented by exogenous fatty acids. hpr1Delta was also synthetically lethal with a previously isolated, temperature-sensitive allele of ACC1, mtr7 (mRNA transport), indicating that the lethality of the acc1(cs) hpr1Delta double mutant was not allele specific. The basis for the interaction between conditional acc1 alleles and hpr1Delta was investigated in more detail. In the hpr1Delta mutant background, acetyl-CoA carboxylase enzyme activity was reduced about 15-fold and steady-state levels of biotinylated Acc1p and ACC1 mRNA were reduced 2-fold. The reduced Acc1p activity in hpr1Delta cells, however, did not result in an altered lipid or fatty acid composition of the mutant membranes but rendered cells hypersensitive to soraphen A, an inhibitor of Acc1p. Similar to mtr7, hpr1Delta and acc1(cs) mutant cells displayed a defect in nuclear export of polyadenylated RNA. Oversized transcripts were detected in hpr1Delta, and rRNA processing was disturbed, but pre-mRNA splicing appeared wild type. Surprisingly, the transport defect of hpr1Delta and acc1(cs) mutant cells was accompanied by an altered ring-shaped structure of the nucleolus. These observations suggest that the basis for the synthetic lethal interaction between hpr1Delta and acc1 may lie in a functional overlap of the two mutations in nuclear poly(A)+ RNA production and export that results in an altered structure of the nucleolus.  (+info)

Diverse oxygenations catalyzed by carbazole 1,9a-dioxygenase from Pseudomonas sp. Strain CA10. (6/1106)

Carbazole 1,9a-dioxygenase (CARDO) from Pseudomonas sp. strain CA10 is a multicomponent enzyme that catalyzes the angular dioxygenation of carbazole, dibenzofuran, and dibenzo-p-dioxin. It was revealed by gas chromatography-mass spectrometry and 1H and 13C nuclear magnetic resonance analyses that xanthene and phenoxathiin were converted to 2,2',3-trihydroxydiphenylmethane and 2,2',3-trihydroxydiphenyl sulfide, respectively. Thus, for xanthene and phenoxathiin, angular dioxygenation by CARDO occurred at the angular position adjacent to the oxygen atom to yield hetero ring-cleaved compounds. In addition to the angular dioxygenation, CARDO catalyzed the cis dihydroxylation of polycyclic aromatic hydrocarbons and biphenyl. Naphthalene and biphenyl were converted by CARDO to cis-1, 2-dihydroxy-1,2-dihydronaphthalene and cis-2,3-dihydroxy-2, 3-dihydrobiphenyl, respectively. On the other hand, CARDO also catalyzed the monooxygenation of sulfur heteroatoms in dibenzothiophene and of the benzylic methylenic group in fluorene to yield dibenzothiophene-5-oxide and 9-hydroxyfluorene, respectively. These results indicate that CARDO has a broad substrate range and can catalyze diverse oxygenation: angular dioxygenation, cis dihydroxylation, and monooxygenation. The diverse oxygenation catalyzed by CARDO for several aromatic compounds might reflect the differences in the binding of the substrates to the reaction center of CARDO.  (+info)

Pharmacokinetics and pharmacodynamics of Ro 44-3888 after single ascending oral doses of sibrafiban, an oral platelet aggregation inhibitor, in healthy male volunteers. (7/1106)

AIMS: This study constituted the first administration of the oral platelet inhibitor, sibrafiban, to humans. The aim was to investigate the pharmacokinetics and pharmacodynamics of Ro 44-3888, the active principle of sibrafiban, after single ascending oral doses of sibrafiban. Particular emphasis was placed on intersubject variability of the pharmacokinetic and pharmacodynamic parameters of Ro 44-3888. METHODS: The study consisted of three parts. Part I was an open ascending-dose study to determine target effect ranges of sibrafiban. Part II, a double-blind, placebo-controlled, parallel-group study, addressed the intersubject variability of pharmacokinetic and pharmacodynamic parameters of the active principle at a sibrafiban dose achieving an intermediate effect. Part III was a double-blind, placebo-controlled, ascending-dose design covering the complete plasma concentration vs pharmacodynamic response curve of sibrafiban. RESULTS: At sibrafiban doses between 5 mg and 12 mg, the pharmacokinetics of free Ro 44-3888 in plasma were linear whereas those of total Ro 44-3888 were non-linear because of the saturable binding to the glycoprotein IIb-IIIa receptor. Saturation of the GP IIb-IIIa receptor was reached at plasma concentrations of 15.9 ng ml-1. At sibrafiban doses up to 2 mg, ADP-induced platelet aggregation was inhibited by 50%, whereas the inhibition of TRAP-induced platelet aggregation was about 20-30%. At the higher doses, ADP-induced platelet aggregation was almost completely inhibited while a clear dose-response could be observed with TRAP-induced inhibition of platelet aggregation at sibrafiban doses of 5 to 12 mg. Ivy bleeding time increased very steeply with dose with a significant prolongation observed at doses of 5 to 7 mg of sibrafiban (5-7 min, >30 min in one case). At a sibrafiban dose of 12 mg, the stopping criterion for dose escalation (prolongation of the Ivy bleeding time >30 min in three out of four subjects per dose group) was reached. The interindividual coefficients of variation of the integrated pharmacokinetic and pharmacodynamic parameters (AUC and AUE) were below 20%, thus lying well within the pre-set level of acceptance. CONCLUSIONS: With a low intersubject variability of its pharmacokinetic and pharmacodynamic parameters, linear pharmacokinetics and pharmacodynamic effects closely related to its plasma concentrations, Ro 44-3888 has good pharmacological prerequisites for a well controllable therapy of secondary prevention of arterial thrombosis in patients with acute coronary syndrome.  (+info)

Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4. (8/1106)

The emergence of X4 human immunodeficiency virus type 1 (HIV-1) strains in HIV-1-infected individuals has been associated with CD4(+) T-cell depletion, HIV-mediated CD8(+) cell apoptosis, and an impaired humoral response. The bicyclam AMD3100, a selective antagonist of CXCR4, selected for the outgrowth of R5 virus after cultivation of mixtures of the laboratory-adapted R5 (BaL) and X4 (NL4-3) HIV strains in the presence of the compound. The addition of AMD3100 to peripheral blood mononuclear cells infected with X4 or R5X4 clinical HIV isolates displaying the syncytium-inducing phenotype resulted in a complete suppression of X4 variants and a concomitant genotypic change in the V2 and V3 loops of the envelope gp120 glycoprotein. The recovered viruses corresponded genotypically and phenotypically to R5 variants in that they could no longer use CXCR4 as coreceptor or induce syncytium formation in MT-2 cells. Furthermore, the phenotype and genotype of a cloned R5 HIV-1 virus converted to those of the R5X4 virus after prolonged culture in lymphoid cells. However, these changes did not occur when the infected cells were cultured in the presence of AMD3100, despite low levels of virus replication. Our findings indicate that selective blockade of the CXCR4 receptor prevents the switch from the less pathogenic R5 HIV to the more pathogenic X4 HIV strains, a process that heralds the onset of AIDS. In this article, we show that it could be possible to redirect the evolution of HIV so as to impede the emergence of X4 strains or to change the phenotype of already-existing X4 isolates to R5.  (+info)

The Pd-catalysed asymmetric intramolecular α-arylation of amideenolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used.
Advances in Heterocyclic Chemistry - 1st Edition - ISBN: 9780124201606, 9780124202092. Paal-Knorr Reaction in the Synthesis of Heterocyclic Compounds.. Thiophene and Its Derivatives, Part 2 (The Chemistry of ... Buy Thiophene and Its Derivatives, Part 2 (The Chemistry of Heterocyclic Compounds, Vol. 44) on Amazon.com ✓ FREE SHIPPING on qualified orders. Chemistry of Heterocyclic Compounds Profession. Heterocyclic compounds are presumably the largest class of organic compounds, obtaining great diversity in chemical and physical properties. Thus Chemistry of Heterocyclic Compounds - CRC Press Book Dec 22, 2014 This book discusses the structure, synthesis, and reactivity of heterocyclic compounds. It covers nomenclature, conformational aspects, Heterocyclic Chemistry - MSU Chemistry Devising a systematic nomenclature system for heterocyclic compounds presented a formidable challenge, which has not been uniformly concluded. Thiophene and Its Derivatives, Part 2 (The Chemistry of ... Buy Thiophene ...
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A new strategy for the synthesis of polycyclic imidazole-containing N-heterocycles, based on the two general synthetic ways, namely the Pd(II)-catalyzed intramolecular arylation via CH/C-Hal and CH/CH coupling reactions, was developed. The method proposed here enables the synthesis of many fused N-heterocycles containing purine, 1-deazapurines and benzimidazole structural units.. ...
Book The Chemistry of Heterocyclic Compounds, Heterocyclic Systems with Bridgehead Nitrogen Atoms: 9780470380826, 0470380829 by W.L. Mosby.Free shipping within USA.
The list of heterocyclic compounds includes many different classifications of heterocyclic compounds, such as aromatic and nitrogen compounds. Find the best heterocyclic compound supplier and product from Echemi.com
Although heterocyclic chemical compounds may be inorganic compounds or organic compounds, most contain at least one carbon. While atoms that are neither carbon nor hydrogen are normally referred to in organic chemistry as heteroatoms, this is usually in comparison to the all-carbon backbone. But this does not prevent a compound such as borazine (which has no carbon atoms) from being labelled heterocyclic. IUPAC recommends the Hantzsch-Widman nomenclature for naming heterocyclic compounds. Heterocyclic compounds can be usefully classified based on their electronic structure. The saturated heterocycles behave like the acyclic derivatives. Thus, piperidine and tetrahydrofuran are conventional amines and ethers, with modified steric profiles. Therefore, the study of heterocyclic chemistry focuses especially on unsaturated derivatives, and the preponderance of work and applications involves unstrained 5- and 6-membered rings. Included are pyridine, thiophene, pyrrole, and furan. Another large class ...
Heterocyclic compound - Comparison with carbocyclic compounds: The molecules of organic chemical compounds are built up from a framework or backbone of carbon atoms to which are attached hydrogen (H), oxygen, or other heteroatoms. Carbon atoms have the unique property of being able to link with one another to form chains of atoms. When the ends of the chains are joined together into a ring, cyclic compounds result; such substances often are referred to as carbocyclic or alicyclic compounds. Substitution of one or more of the ring carbon atoms in the molecules of a carbocyclic compound with a heteroatom gives a heterocyclic compound. A typical carbocyclic compound
A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.. ...
Many abundant and highly bioactive natural alkaloids contain an indolizidine skeleton. A simple, high yielding method to synthesize this scaffold from N-heterocycles was developed. A wide range of pyridines, quinolines and isoquinolines reacted with donor-acceptor (DA)-aminocyclopropanes via an ytterbium(iii
Plerixafor in combination with bevacizumab is a drug combination that may stop cancer cells from growing abnormally. Bevacizumab, also known as Avastin, is FDA approved for use in patients with recurrent glioblastoma and has been studied extensively in other types of solid tumors. Plerixafor, also known as Mozobil, is FDA approved for use in patients with non-Hodgkins lymphoma and multiple myeloma and has been used in treatment for other cancers. Information from experiments in laboratories suggests that the combination of plerixafor and bevacizumab may help prevent the growth of gliomas.. Part 1: The investigators are looking for the highest dose of plerixafor that can be given safely with bevacizumab (with a 21 days on/7 days off regimen of plerixafor). The investigators will also do blood tests to find out how the body uses and breaks down the drug combination.. Part 2: The investigators are looking to see if plerixafor can get past the blood-brain barrier and into brain tumors. The ...
Plerixafor in combination with bevacizumab is a drug combination that may stop cancer cells from growing abnormally. Bevacizumab, also known as Avastin, is FDA approved for use in patients with recurrent glioblastoma and has been studied extensively in other types of solid tumors. Plerixafor, also known as Mozobil, is FDA approved for use in patients with non-Hodgkins lymphoma and multiple myeloma and has been used in treatment for other cancers. Information from experiments in laboratories suggests that the combination of plerixafor and bevacizumab may help prevent the growth of gliomas.. Part 1: The investigators are looking for the highest dose of plerixafor that can be given safely with bevacizumab (with a 21 days on/7 days off regimen of plerixafor). The investigators will also do blood tests to find out how the body uses and breaks down the drug combination.. Part 2: The investigators are looking to see if plerixafor can get past the blood-brain barrier and into brain tumors. The ...
An efficient strategy for the synthesis of α,β-unsaturated enaminones by the nucleophilic addition of N-heterocycles such as indole and imidazoles onto electronically bias alkynones under mild reaction conditions is described. Key feature of this reaction is the chemoselective addition of N-heterocycles onto ynones without affecting the 1° amino groups (aromatic and aliphatic) of 5-aminoindole and tryptamine. The stereochemistry of the products was controlled by the tuning of reaction time. The mechanism of the reaction involves the Michael type addition of N-heterocycles on ynones via allene formation.. ...
C07D207/34-Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms ...
Plerixafor, also known as AMD3100, is a bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Plerixafor was approved by the U.S. Food and Drug Administration for this indication on December 15, 2008. In Europe, the drug was approved on 29 May 2009.
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A class of heterocyclic compounds that include four or more fused rings. Both aromatic or non-aromatic ring structures are included in this category.
This statistic shows the sales value of heterocyclic compounds with nitrogen only hetero-atom(s) based on PRODCOM estimates** in the United Kingdom (UK) between 2010 and 2018.
The invention relates to an N-heterocyclic carbene complex of general formulas I to IV (I) (II) (III) (IV), according to which A1 stands for NR2 or PR2, A2 stands for CR2R2, NR2, PR2, O or S, A3 stands for N or P, and C stands for a car ...
Collecting sufficient CD34+ autologous stem cells could enable eligible individuals with specific malignancies to proceed to autologous hematopoietic stem cell transplantation (HSCT). Plerixafor injection is a hematopoietic stem cell mobilizer that is given subcutaneously (SQ) with granulocyte colony stimulating factor (G-CSF). Also known as AMD3100 in early clinical studies, plerixafor injection is the first agent in a class of small molecules that reversibly inhibits the CXCR4 chemokine receptor and blocks binding of the stromal cell-derived factor-1α (SDF-1α). CXCR4 and SDF-1α play a role in the homing of human HSC to the bone marrow (DiPersio, 2009b; Product Information Label, 2013). HSC binding is inhibited with plerixafor injection which releases (mobilizes) CD34+ stem cells from the marrow into the bloodstream where they can be collected through apheresis for subsequent autologous HSCT to treat individuals with multiple myeloma (MM) or non-Hodgkin lymphoma (NHL) (Giralt, 2009).. The ...
An effective wake-up call: Stable α,β-unsaturated esters were activated by the addition of a chiral N-heterocyclic carbene (NHC) organocatalyst, and the resulting reactive Michael acceptor intermediates reacted with enamide nucleophiles to furnish optically pure products (see scheme; Ts=p-toluenesulfonyl). These products can be converted readily into bioactive δ-lactams, piperidines, and their derivatives. ...
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Heterocyclic systems are of widespread occurrence in nature, particularly in such natural products as nucleic acids, plant alkaloids, anthocyanins and flavones,
A new series of gold(I) N-heterocyclic carbene (NHC) complexes based on xanthine ligands have been synthesized and characterized by mass spectrometry, NMR, and X-ray diffraction. The compounds hav ...
The use of an air and moisture stable, commercially available (N-heterocyclic carbene)-Pd complex as precatalyst allows for the Buchwald-Hartwig polyamination of aryl chlorides with primary amines. Different approaches for the end-capping of the polymers have also been evaluated. The step growth polymerizations exhibit molecular weight from 2000 to 15000 Da and PDI from 1.1 (2000 Da) to 3.0 ...
TY - JOUR. T1 - One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines. AU - Martinez-Ariza, Guillermo. AU - McConnell, Nicholas. AU - Hulme, Christopher. PY - 2016/4/15. Y1 - 2016/4/15. N2 - A cesium carbonate promoted three-component reaction of N-H containing heterocycles, primary or secondary amines, arylglyoxaldehydes, and anilines is reported. The key step involves a tandem sequence of N-1 addition of a heterocycle or an amine to preformed α-iminoketones, followed by an air- or oxygen-mediated oxidation to form α-oxo-acetamidines. The scope of the reaction is enticingly broad, and this novel methodology is applied toward the synthesis of various polycyclic heterocycles.. AB - A cesium carbonate promoted three-component reaction of N-H containing heterocycles, primary or secondary amines, arylglyoxaldehydes, and anilines is reported. The key step involves a tandem sequence of N-1 addition of a heterocycle or an amine to ...
Plerixafor is a bicyclam derivative that acts as a stem cell mobiliser by blocking the CXCR4 chemokine receptor. Plerixafor was synthesized by Johnson Matthey
A new one-pot preparative route was developed to synthesize novel organophosphorus sulfur heterocycles via the reaction of the four-membered ring thionation reagent [2,4-diferrocenyl 1,3,2,4-diathiadiphosphetane 2,4-disulfide (FcLR, a ferrocene analogue of Lawessons reagent)] and alkenyl/aryl-diols and I2 (or SOCl2) in the presence of triethylamine. Therefore, a series of five- to ten-membered heterocycles bearing an O-P(S)-O or an O-P(S)-S-S-P(S)-O linkage were synthesized. The synthesis features a novel application of the multicomponent reaction, providing an efficient and environmentally benign method for the preparation of the unusual phosphorus-sulfur heterocycles. Seven representative X-ray structures confirm the formation of these heterocycles ...
Nomenclature. Electrophilic substitutions reactions of fNomenclature. Electrophilic substitutions reactions of furan, thiophene, pyrrole, indole, benzofuran and benzothiophene; reactions with bases, nucleophiles and metallations reactions. Synthesis of Paal-Knorr, Knorr, Hantzsch, Feist-Benary, Fischer, Reissert. The use of N-oxides of pyridine in substitution reactions of the pyridine nucleus. Reaction of Chichibabin and metallation of the alkyl pyridines. Synthesis from 1,5-diketones, followed by oxidation, synthesis of Hantzsch. Synthesis of pyrimidine nucleus from 1,3-dicarbonyl compounds (β-diketones + amidine, β-diketones + guanidine). Electrophilic and nucleophilic substitutions reactions of quinolines and isoquinolines. Skraup and Bischler-Napieralski synthesis.. ...
The addition of alkynes to a staturated N-heterocyclic carbene (NHC)-supported diboryne results in spontaneous cycloaddition, with complete B≡B and C≡C triple bond cleavage, NHC ring- expansion and activation of a variety of C-H bonds, leading to the formation of complex mixtures of fused B,N-heterocycles ...
The antimicrobial properties of tulathromycin were investigated for M.haemolytica and P.multocida. Three invitro indices of antimicrobial activity, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill curves, were established for six isolates of each organism. Each index was measured in two growth media: Mueller-Hinton broth (MHB) and calf serum. It was shown that MICs and MBCs were markedly lower in serum than in MHB. MHB:serum ratios for MIC were 47:1 (M.haemolytica) and 53:1 (P.multocida). For both serum and MHB, adjustment of pH led to greater potency at alkaline compared to acid pH. Tulathromycin MIC was influenced by size of inoculum count, being 4.0- to 7.7-fold greater for high compared to low initial counts. It was concluded that for the purpose of determining dosages for therapeutic use, pharmacodynamic data for tulathromycin should be derived in biological fluids such as serum. It is hypothesized that invitro measurement of MIC in broth, ...
BALLYA test for tulathromycin used for detection tulathromycin residues in feed and food. Just only 15 minutes to result. Rapid test manufacturer directly supply. Low cost, worldwide shipping. BALLYA Tulathromycin test kit wholesale.
A number of novel triazinoquinazolinones (5b,c and 8), triazepinoquinazolinones(5a, 6b, 7 and 9) and triazocinoquinazolinones (6a and 10) were obtained via nucleophilic interaction of 3-aminoquinazolinone derivatives 3 with different reagents.
MSB inhibits adhesion of sialyl Lewisx (sLex)-expressing HL-60 cells to LSP-activated (E-selectin-expressing) HUVECs in vitro. When MSB was administered to B16/BL6 mice at 20 mg/kg/day, lung metastatic nodules of B16/BL6 mouse melanoma cells (B16/BL6 cells) were significantly decreased (T/C = 45%). Flow cytometry analysis showed that B16/BL6 cells expressed high levels of sLex antigens. Under in vitro conditions, B16/BL6 cells demonstrated a greater degree of adhesion to LSP-activated HUVECs, but adhesion was significantly inhibited by MSB and sLex antibodies. Combined therapy of MSB and cisplatin (CDDP) induced remarkable lung metastasis inhibition without the adverse effects, of CDDP to the host.. ...
Beginning in 2004, Bode and co-workers extended the use of NHCs as organocatalysts by developing new approaches to the catalytic generation of reactive species including activated carboxylates, homoenolates, and enolates. Critical to the success of these processes is an N-mesityl substituent on an imidazolium or triazolium NHC precursor. These novel catalysts and reactions make possible a new generation of highly enantioselective annulations from simple starting materials under mild reaction conditions, usually at room temperature and without added reagents. For example, chiral (683973) catalyzes an inverseelectron demand Diels-Alder reaction of activated enals and α,β-unsaturated imines to afford cis-dihydropyridinones with outstanding selectivity (Scheme 2).3 The use of α-chloro aldehydes as starting materials is viable, and also makes possible enantioselective annulations with enones using less than 1 mol % of the chiral NHC catalysts (Scheme 3).4 These catalysts promote highly ...
An object of the present invention is to provide a compound and pharmaceutical composition showing superior stability and/or solubility, etc. and having superior FLT3 inhibitory activity. The present
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The present invention relates to the compounds of Formula 1 wherein M is Sc or Y, Hal is CI, Br, F or I R is alkyl with 1 - 4 atoms of C X is CI, Br, F or I or a group such as that shown hereinafter wherein R is alkyl with 1 - 4 atoms of ...
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5 -Methoxy-2 [ [(4-methoxy-3,5 -dimethyl-2-pyridinyl)methyl]sulfinyl] -1 H-benzimidazole (25 g, 72.4 mmol) together with isopropylamine (7.4 ml, 86.9 mmol) was added to methanol (100 ml). To the mixture Mg(NO3)2 x 6 H2O (11.2 g, 43.7 mmol) was added at ambient temperature. After the reaction was completed inorganic salts were removed by means of filtration. Water was added to the filtrate, the mixture was filtered and the filter cake was washed with methanol (10 ml). Water (100 ml) was added dropwise to the combined organic layers. The product was filtered off and was washed with a mixture of MeOH/water (50 ml, 1:1). The product was dried overnight. Yield: 89%. (Mg content: 3.39; calculated theoretically: 3.41 ...
本論文主要研究鍾萼木 (Bretshneidera sinensis Hemsley)的含硫生物鹼成分,先將其枝葉部分用酒精萃取後,得到的萃取物再利用各種管柱色層分離方法進行分離,最後再用儀器鑑定其所含的化學組成成分。實驗結果共分離了六個化合物,六個都為首次發現的含硫之生物鹼 (sulfur-containing alkaloids)。分離得到的新化合物中,共有四個屬於3-methyl-1,3-benzothiazine-2,4-dione骨架的雜環化合物 (heterocyclic compounds, 1-4)及兩個骨架為 N-benzyl-S-methyl-thiocarbamate的含硫生物鹼 (5-6)分離得到的化合物結構利用核磁共振圖譜1D NMR (1H NMR 和 13C NMR)及2D NMR (HSQC、HMBC)進行結構解析,再加上各種物理數據分析,包含熔點、紫外線吸收光普及高解析電灑式質譜儀,最後再利用化學結構資料庫 (Reaxys)進行相關文獻比對確認。所分離得到的新化合物已送測抗發炎以及抗癌細胞的生物活性檢測。
Towarzystwo o profilu zawodowo-naukowym, którego działalność skupia się głównie na wspieraniu rozwoju nauk farmaceutycznych oraz reprezentacji zawodu farmaceuty, założone w 1947 z siedzibą w Warszawie.
ORGANIC COMPOUNDS -- PART OF THE CLASS 532-570 SERIES : : : Hetero ring is five-membered consisting of one nitrogen and four carbons (e.g., halopyrrolidines, etc.) : Polycyclo ring system having the five-membered hetero ring as one of the cyclos : Bicyclo ring system having the five-membered hetero ring as one of the cyclos (e.g., octahydroindoles, etc.) : Additional polycyclo heterocyclic ring system attached directly or indirectly to the bicyclo ring system by nonionic bonding : The additional polycyclo heterocyclic ring system has a lactone ring as one of the cyclos : Ring carbon of each of the two five-membered hetero rings is bonded directly to chalcogen or nitrogen (e.g., both rings may be bonded to the same nitrogen atom or to different nitrogen atoms, etc ...
Inconsistent risk estimates for dietary heterocyclic amine (HCA) exposure and cancers may be due to differences in exposure assessment methods and the associated measurement error. We evaluated repeatability and comparability of intake estimates of the HCA 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) among two food frequency questionnaire (FFQ) collections, three diary collections, and th
Heterocyclic compounds play an important role in our ongoing interest in developing new antimicrobial agents (Isloor et al., 2000; Isloor et al., 2009). The quinoline nucleus is one of the most important and widely exploited heterocyclic ring systems for the development of bioactive molecules (Caprio et al., 2000). Members of this family have a wide range of applications in pharmacology as antimalarial (Kaur et al., 2010), antitumor (Chou et al., 2010), anticancer (Chen et al., 2004), antimicrobial (Garudachari et al., 2012) and antiviral (Shingalapur et al., 2009) agents. In view of the promising biological and pharmaceutical activity, the title compound was synthesized to study its crystal structure.. The aromatic scaffold is essentially flat. The least-squares plane defined by all the non-hydrogen atoms (r.m.s. of all fitted atoms = 0.0175 Å) features the carbon atom bearing the trifluoromethyl group as the atom deviating most from this common plane by 0.029 (1) Å. The least-squares planes ...
TY - JOUR. T1 - Polycyclic N-heterocyclic compounds. Part 70. T2 - Synthesis of 5-amino-1,2-dihydrofuro[2,3-b]pyrido[3,2:4,5]-thieno[3,2-d]pyridines and related compounds. Evaluation of effects on lipoprotein lipase mRNA expression. AU - Okuda, Kensuke. AU - Takechi, Hideyasu. AU - Hirota, Takashi. AU - Sasaki, Kenji. PY - 2011/5/26. Y1 - 2011/5/26. N2 - Reaction of 3-(3-cyanopropoxy)thieno[2,3-b]pyridine-2-carbonitriles with potassium tert-butoxide gave 5-amino-1,2-dihydrofuro[2,3-b]pyrido- [3,2:4,5]thieno[3,2-d]pyridines via a Truce-Smiles rearrangement. The 5-amino group was transformed to the chloro derivatives which were allowed to react with various nucleophiles. Effects of the newly synthesized compounds on lipoprotein lipase mRNA expression were also evaluated. The previously unreported parent compound, furo[2,3-b]pyrido[3,2:4,5]thieno[3,2-d]pyridine, was also synthesized.. AB - Reaction of 3-(3-cyanopropoxy)thieno[2,3-b]pyridine-2-carbonitriles with potassium tert-butoxide gave ...
article{8169264, abstract = {The synthesis of ruthenium indenylidene complexes containing mixed N-heterocyclic carbene ligands featuring one sterically small NHC [IMe(Me) (1,3,4,5-tetramethylimidazol-2-ylidene), I(i)Pr(Me) (1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene), and ICy (1,3-dicyclohexylimidazol-2-ylidene)] and one larger congener SIMes (1,3-bis-(2,4,6 trimethylphenyl)imidazolin-2-ylidene) is described. Characterization by X-ray diffraction allowed for calculation of percent buried volume of the small NHCs in these complexes and for speculation on the relationship NHC/catalytic activity. In addition, these complexes displayed an enhanced stability but also a high ability to promote ring-closing metathesis reactions at catalyst loadings as low as 0.05 mol %.}, author = {Bantreil, Xavier and Randall, Rebecca AM and Slawin, Alexandra MZ and Nolan, Steven}, issn = {0276-7333}, journal = {ORGANOMETALLICS}, keywords = {RING-CLOSING METATHESIS,INDENYLIDENE COMPLEXES,TETRASUBSTITUTED ...
Title: Metal-mediated Heterocyclization: Synthesis of Heterocyclic Compounds Containing More Than One Heteroatom Through Carbon-Heteroatom Bond Forming Reactions. VOLUME: 14 ISSUE: 8. Author(s):K. C. Majumdar, B. Roy, P. Debnath and A. Taher. Affiliation:Department of Chemistry, University of Kalyani, Kalyani- 741 235, India.. Abstract: Heterocyclic compounds are versatile building blocks in organic synthesis. These are important part in various natural products and bioactive compounds. Several methodologies have been developed to synthesize these heterocyclic compounds. This review article covers an updated (published during 2005 to 2008) summary of transition-metal catalyzed approaches for the syntheses of commonring heterocycles containing more than one heteroatom via the selective formation of carbon-heteroatom bonds. The five-membered ring heterocycles with two nitrogen atoms include imidazoles, pyrazoles, indazoles, imidazoindolones etc. and heterocycles with one nitrogen and one oxygen ...
DFT and Quantum Chemical Studies for Heterocyclic Compounds, 978-3-659-21601-5, 9783659216015, 3659216011, Inorganic chemistry , The study of corrosion processes and their inhibition by organic inhibitors is a very active field of research. The presence of nitrogen, oxygen, phosphorous and sulphur in the organic molecules has a major effect on the inhibition efficiency and consequently on the phenomenon of adsorption on some metals surface. A great number of heterocyclic compounds were found to be excellent inhibitors of copper and steel corrosion. The inhibition effect mainly depends on some physicochemical and electronic properties of the organic inhibitor which relate to its functional groups, steric effects, electronic density of donor atoms, and orbital character of donating electrons. DFT Quantum chemical methods have already proven to be very useful in determining the molecular structure as well as elucidating the electronic structure and reactivity. Thus, it has become a common practice to
Substituted heteroaromatic compounds, and in particular substituted bicyclic heteroaromatic compounds in which one ring is a pyridine or pyrimidine of formula (I) are protein tyrosine kinase inhibitors. The compounds are described as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of cancer and psoriasis.
TY - JOUR. T1 - Efficient and phosphine-free bidentate N-heterocyclic carbene/ruthenium catalytic systems for the dehydrogenative amidation of alcohols and amines. AU - Wu, Xuan Jun. AU - Wang, Hua Jing. AU - Yang, Zhao Qi. AU - Tang, Xiao Sheng. AU - Yuan, Ye. AU - Su, Wei. AU - Chen, Cheng. AU - Verpoort, Francis. PY - 2019/3/7. Y1 - 2019/3/7. N2 - The direct amide synthesis from alcohols and amines applying various transition metal catalysts has been demonstrated as an attractive and promising process. Among various catalytic systems, N-heterocyclic carbene (NHC)-based ruthenium (Ru) ones have been testified to be active for this atom-economic transformation. Although a variety of imidazole-based NHC/Ru catalytic systems were reported to be active for this reaction, the benzimidazole-based analogs exhibited higher catalytic performance in most cases. However, these catalytic systems, which comprise a monodentate NHC ligand and a Cl or phosphine ligand as the key components, require relatively ...
TY - JOUR. T1 - Palladium (0) olefin complexes bearing purine-based N-heterocyclic carbenes and 1,3,5-triaza-7-phosphaadamantane (PTA). T2 - Synthesis, characterization and antiproliferative activity toward human ovarian cancer cell lines. AU - Scattolin, Thomas. AU - Pangerc, Nicola. AU - Lampronti, Ilaria. AU - Tupini, Chiara. AU - Gambari, Roberto. AU - Marvelli, Lorenza. AU - Rizzolio, Flavio. AU - Demitri, Nicola. AU - Canovese, Luciano. AU - Visentin, Fabiano. PY - 2019/10/30. Y1 - 2019/10/30. N2 - A complete series of new η2-olefin palladium (0) complexes bearing purine-based N-heterocyclic carbenes or PTA (1,3,5-triaza-7-phospaadamantane) as spectator ligands have been synthetized and exhaustively characterized. The first single-crystal X-ray structure of a PTA complex of palladium (0) have been also reported. The most part of these compounds have been tested as antiproliferative agents toward two different human ovarian cancer cell lines A2780 and A2780cis, respectively cisplatin ...
N-Methyl-N-nitrosotoluene-4-sulphonamide, find complete details about N-Methyl-N-nitrosotoluene-4-sulphonamide, Heterocyclic compound, Thiophene compounds, Aromatics - Baoji GuoKang Bio-Technology Co., Ltd.
N-Heterocyclic carbenes (NHCs) have been shown to be exceptional ligands for molecular coordination chemistry due to their ability to form strong carbon-metal bonds. Only recent, our group and others have demonstrated that the strong carbon-metal bonding properties of NHCs can be leveraged for materials chemistry. In 2014, Crudden and co-workers showed that self-assembled monolayers (SAMs) derived from NHCs on gold surfaces were significantly more stable than thiolate SAMs; which, for decades, have been considered the state-of-the-art in SAM chemistry. Since then, our group has continued to advance the field by incorporating unique functionalities to NHCs and new methods of SAM formation. In addition, stability of NHCs in different chemical and electrochemical conditions was critical to determine NHCs use in biological and industrial applications. In this thesis, I will present the use of electrochemical measurement of NHCs in phosphate buffer are discussed to confirm the prospective use of ...
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Search for From Heterocyclic Compound Containing A Sulfur Atom As A Ring Member Patents and Patent Applications (Class 528/377) Filed with the USPTO
You begin chemistry of heterocyclic compounds isoxazoles part 2 volume is originally deliver! Your Web Introduction is right dated for work. Some blocks of WorldCat will well offer internal.
In 2018, Top exporters of Heterocyclic compounds; lactams; other than 6-hexanelactam (epsilon caprolactam) are Ireland ($7,633,206.93K , 27,279 Kg), Belgium ($7,187,788.89K , 15,915,500 Kg), European Union ($2,162,593.57K , 38,129,100 Kg), Singapore ($1,075,335.30K , 712,056 Kg), United Kingdom ($823,439.86K , 254,932 Kg ...
Heterocyclic amines are a group of chemical compounds, many of which can be formed during cooking. They are found in meats that are cooked to the well done stage, in pan drippings and in meat surfaces that show a brown or black crust. Epidemiological studies show associations between intakes of heterocyclic amines and cancers of the colon, rectum, breast, prostate, pancreas, lung, stomach/esophagus and animal feeding experiments support a causal relationship. The U.S. Department of Health and Human Services Public Health Service labeled several heterocyclic amines as likely carcinogens in its 13th Report on Carcinogens. Changes in cooking techniques reduce the level of heterocyclic amines. More than 20 compounds fall into the category of heterocyclic amines, often abbreviated HCAs[1]. Table 1 shows the chemical name and abbreviation of those most commonly studied. All four of these compounds are included in the 13th Report on Carcinogens. The compounds found in food are formed when creatine (a ...
TY - PAT. T1 - Heteroaromatic compounds and their use as dopamine D1 ligands. AU - Allen, John. PY - 2017/4/11. Y1 - 2017/4/11. UR - http://pdfpiw.uspto.gov/.piw?Docid=09617275&homeurl=http%3A%2F%2Fpatft.uspto.gov%2Fnetacgi%2Fnph-Parser%3FSect1%3DPTO2%2526Sect2%3DHITOFF%2526p%3D1%2526u%3D%25252Fnetahtml%25252FPTO%25252Fsearch-bool.html%2526r%3D4%2526f%3DG%2526l%3D50%2526co1%3DAND%2526d%3DPTXT%2526s1%3D9,617,275%2526OS%3D9,617,275%2526RS%3D9,617,275&PageNum=&Rtype=&SectionNum=&idkey=NONE&Input=View+first+page. M3 - Patent. M1 - 9,617,275 B2. PB - United States Patent Office. ER - ...
Heterocyclic compounds are enormously crucial in various industries including food, agricultural, cosmetics and pharmaceuticals. Heterocyclic pharmacophores are one of the main chemical components in drug discovery research. A report in 2013 claims that four out of six and nine out of twenty one highest selling medicines in the world are small molecule heterocyclic compounds. Therefore, easy access of medicinally active heterocycles or drug candidates is essential for a routine structure-activity relationship (SAR) study. Reactions under environmentally benign conditions following green chemistry techniques are a subject of intensive investigation. Microwave-induced rapid synthesis of organic compounds helps to reduce waste formation by reducing unwanted side reactions, maintaining atom economy, and providing products with high yield and, in many instances, with predictable stereochemistry.. Since the discovery of microwave-induced reactions in synthetic organic chemistry in 1986, this method ...
CAS Number: 1025728-56-6. Product class: Homogeneous Catalysts, Hoveyda-Grubbs Catalyst® 2nd Generation, M-C, Carbene Ligands, Alkoxybenzylidene Ligands, N-Heterocyclic Carbene Ligands, SIMes. Reaction type: Alkene Metathesis, Cross Metathesis, Ring Closing Metathesis, Self Metathesis. ...
Mousy off-flavor is an insidious and economically disastrous microbiologically derived spoilage characteristic of wine and other fermented beverages. Tainted wines are rendered unpalatable and there is currently no satisfactory procedure for removal of the off-flavor. Here we report the confirmation of that both D- and L-lysine can act as a precursor for the formation of mousy off-flavor N-heterocycles. Further, through the use of stable isotope feeding experiments, we could establish that a pentylamine group from lysine is incorporated into the piperideine moiety of two off-flavor N-heterocycles. A biochemical pathway for the formation of mousy off-flavor compounds is proposed ...
0118] wherein R1 is a cycloalkyl group, a cycloalkyl group having a substituent(s), wherein, when the cycloalkyl group is a cyclopropyl group said cyclopropyl group has a substituent(s), a cycloalkenyl group or a cycloalkenyl group having a substituent(s); each R2 and R3 is a hydrogen atom or an alkyl group; R4 is an alkyl group, an alkyl group having a substituent(s), an alkenyl group, an alkenyl group having a substituent(s), a cycloalkyl group, a cycloalkyl group having a substituent(s), a cycloalkenyl group, a cycloalkenyl group having a substituent(s), an aryl group, an aryl group having a substituent(s), an aromatic heterocyclic group having at least one hetero-atom within a ring or an aromatic heterocyclic group having a substituent(s) and at least one hetero-atom within a ring; A is a heterocyclic ring or a heterocyclic ring having a substituent(s); B is an aromatic ring, an aromatic ring having a substituent(s), a heterocyclic ring or a heterocyclic ring having a substituent(s); n is an ...
Directory of patents filed by John L Lemanowicz (123 patents): Method for forming pluralities of droplets and polymer particles having low polydispersity; Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors; Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors; Fused heterocyclic compounds as protein tyrosine kinase inhibitors; Process and apparatus for forming plastic sheet
Binuclear complexes of rhodium(I) of the type [(dien)(X)Rh(μ-N-N)Rh(X)(dien)] (dien = 1,5-cyclooctadiene or norbornadiene; N-N = pyrazine, 4,4′-bipyridine or Phenazine and X = Cl or Br) with bridging heterocycles have been isolated and their reactions with carbon monoxide, 2,2′-bipyridine and 1,10-phenanthroline investigated. The crystal structure of [(COD)(Cl)Rh(μ-pyrazine)Rh(Cl)(COD)] has been determined.. ...
Prostate Cancer is the most frequently diagnosed malignancy and second leading cause of cancer-related Death among men in the United States. Identifying risk factors of this disease and developing strategies for prevention are critical. A number of epidemiologic studies have reported an association between frequent consumption of well-done cooked meats, containing the heterocyclic aromatic amine (HAA) 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine (PhIP) and Prostate Cancer risk. PhIP is a potent rodent prostate carcinogen, and it induces oxidative stress, atrophy of the acini, and inflammation of the prostate. These are critical features that occur in human prostate carcinogenesis. A paradigm has been put forth for a causal role of consumption of well-done cooked meats containing PhIP (and other HAAs) in the etiology of Prostate Cancer; however, biomarkers of exposure and DNA damage are lacking to validate this model. Our long-term goal is to assess the cancer risk posed by HAAs, by employing ...
In this study, the potential of synchronous front-face fluorescence spectroscopy (SFS) coupled with chemometrics was investigated for the determination of heterocyclic aromatic amines (HAA) in coo ...
TY - JOUR. T1 - The synthesis and antimicrobial activity of heterocyclic derivatives of totarol. AU - Kim, Michelle B.. AU - OBrien, Terrence E.. AU - Moore, Jared T.. AU - Anderson, David E.. AU - Foss, Marie H.. AU - Weibel, Douglas B.. AU - Ames, James B.. AU - Shaw, Jared T.. PY - 2012/10/11. Y1 - 2012/10/11. N2 - The synthesis and antimicrobial activity of heterocyclic analogues of the diterpenoid totarol are described. An advanced synthetic intermediate with a ketone on the A-ring is used to attach fused heterocycles, and a carbon-to-nitrogen atom replacement is made on the B-ring by de novo synthesis. A-ring analogues with an indole attached exhibit, for the first time, enhanced antimicrobial activity relative to the parent natural product. Preliminary experiments demonstrate that the indole analogues do not target the bacterial cell division protein FtsZ as had been hypothesized for totarol.. AB - The synthesis and antimicrobial activity of heterocyclic analogues of the diterpenoid ...
Functionalized nitrogen heterocyclic compounds, including benzodiazepines and azasugars, and synthetic methods for preparing such compounds. Nitrogen-containing heterocycles are prepared by reacting amino-carbonyl compounds that contain an amine moiety connected via a linker to a carbonyl moiety with an organoboron derivative.
CAS Number: 1307233-23-3. Product class: Homogeneous Catalysts, Grubbs Catalyst® 2nd Generation, M-C, N-Heterocyclic Carbene Ligands, SIPr, M-P, Phosphorus Ligands - Achiral. Reaction type: Alkene Metathesis, Cross Metathesis, Enyne Metathesis, Ring Closing Metathesis, Self Metathesis. ...
Cyclam is doubly protonated in [H2(cyclam)(maleate)2], resulting in a maleate monoanion. The di-protonated cyclam [C10H26N4]2+ exhibits bond distances and angles in the range usually found in the literature (Melson, 1979). The two additional protons on N1 and N1A are trans to each other and interact through hydrogen bonds with the nonprotonated N2 and N2A nitrogen atoms [N1···N2= 2.800 (1) Å, N3···N4= 2.805 (1) Å]. The diprotonated macrocycle adopts an quadrangular (3,4,3,4)-C conformation (Fig. 1) according to Dales nomenclature [(Dale, 1973 and 1976, (Hancock et al., 1996)], where the exo-cyclic nitrogen atom N2 is located two bonds away from the adjacent corner atoms C9A and C11, while the amine nitrogen atom N1A is located one bond away from the corresponding corner atom C9A and two bonds away from C11A. According to the stereochemical classification of 1,4,8,11 tetraazacyclotetradecane introduced by Bosnich et al. (1965), the cyclam ring adopts a trans-III geometry type, which, ...
Abstract Due to your efforts diligent on quinoline nucleus new series containing pyrimido [4, 5-b] quinoline were synthesized via starting with the strategic 2-aminoquinoline-3-carbonitrile (2) intermediates to afford various pyrimido [4, 5-b] quinoline via cyclization with different reagents to get compounds 3-24. Compounds 3, 6, 9a, 9b, 12, 15, 16a, 16b, 17, 21 and 24 were tested for in vitro antitumor activity against human breast carcinoma (MCF-7) cell line, We found what we were hoping for where compound 6 was found the most active member (IC50= 48.54 μM) than the Doxorubicin as a reference drug with (IC50= 71.80 μM). To understand the interaction of binding sites with the target protein receptor, the docking study was performed using topoisomerase II. The results of in vitro cancer activity and docking study revealed that the synthesized compounds have potential cancer activity and can be further optimized and developed as a lead compound.. ...
0121] U4 is an optionally substituted bivalent radical selected from the group C1-C6alkyl, C0-C6alkyl-Q, C2-C6alkenyl-Q, and C2-C6alkynyl-Q: where the substituents on any alkyl, alkenyl or alkynyl are 1-3 R38; Q4 is absent or is selected from the group --O--, --S(O)s--, --SO2--N(R30)--, --N(R30)--, --N(R30)--C(═O)--, --N(R30)--C(═O)--N(R30--), --N(R30)--C(═O)--O--, --N(R30)--SO2--, --C(═O)--O--, C(═O)--O--, -het-, --C(═O)--N(R30)--, --O--C(═O)--N(R30)--, --PO(OR30)O-- and --P(O)O--; where s is 0-2 and het is a mono- or bicyclic 5, 6, 7, 9 or 10 member heterocyclic ring, each ring containing 1-4 heteroatoms selected from N, O and S, where the heterocyclic ring may be saturated, partially saturated, or aromatic and any N or S being optionally oxidized, the heterocyclic ring being substituted with 0-3 R41; V4 is absent or is an optionally substituted bivalent group selected from C1-C6alkyl, C3-C8cycloalkyl, C0-C6alkyl-C6-C10aryl, and C0-C6alky-het; where the substituents on any alkyl ...
30e V for the second: it corresponds to the ionization of the lone pair of the amino group that is conjugated with the ring T system. 75 eV. 5 eV corresponding to the nitro group. All the assignments could be confirmed with good precision by CNDO/S calculations (Table 1-20). Bernardi et al. (131) have studied the halogen derivatives experimentally and theoretically. The experimental assignments have been compared successfully to theoretical results obtained by ab initio STO-3G and 4-31G methods (192, 193). Various isotopically labeled thiazoles have been synthezised for physicochemical purposes: 2- and 5-deutero and 25 I. 6N D2S0, at 118 for 8 days (111). 5 moles of nondeuterated thiazole, resulted from the thermal decarboxylation of thiazol-4-yldeuterocarboxylicacid (1 13). N-Thiazole was prepared from labeled thiourea through the Hantzsch cyclization with 1,2-dichloroethoxyethane, Sandmeyer bromination of the 2-aminothiazole, and reduction by zinc and acetic acid of the 15N-2-bromothiazole ...
Process for preparing compounds of the formula (I) in which R1 represents a hydrogen atom or an alkyl group, A represents an ethylene group, which may be substituted by alkyl, or a trimethylene group, which may be substituted by alkyl, X represents an oxygen or sulphur atom or the group in which R3 represents a hydrogen atom or an alkyl group, and Z represents an optionally substituted 5- or 6-membered heterocyclic group which contains at least two heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, or denotes an optionally substituted 3- or 4-pyridyl group, characterized in that compounds of the formula (II) in which A and X are each as defined above are reacted with compounds of the formula (III) in which R1 and Z are each as defined above and M1 denotes a halogen atom or the group -OSO2-M2, in which M2 denotes a C1-C6-alkyl group, an aryl group or OM3, where M3 denotes a C1-C6-alkyl group or an alkali metal, in the presence of an alcohol which is not or is ...
Oxetorone (INN), as oxetorone fumarate (USAN) (brand names Nocertone, Oxedix), is a serotonin antagonist, antihistamine, and alpha blocker used as an antimigraine drug. Association with hyperprolactinemia has been described ...
Nonene is an alkene with the molecular formula C9H18. Many structural isomers are possible, depending on the location of the C=C double bond and the branching of the other parts of the molecule. Industrially, the most important nonenes are trimers of propene ...
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TY - JOUR. T1 - Nitro azines. 21. Reactivities and electron structures of 6-nitroazolo[1,5-a]pyrimidines. AU - Myasnikov, A. V.. AU - Torgashev, P. A.. AU - Pilicheva, T. L.. AU - Rusinov, V. L.. AU - Gromova, S. A.. AU - Trofimova, M. G.. AU - Velik, A. V.. AU - Chupakhin, O. N.. PY - 1993/6/1. Y1 - 1993/6/1. UR - http://www.scopus.com/inward/record.url?scp=34249772154&partnerID=8YFLogxK. U2 - 10.1007/BF00531550. DO - 10.1007/BF00531550. M3 - Article. AN - SCOPUS:34249772154. VL - 29. SP - 694. EP - 700. JO - Chemistry of Heterocyclic Compounds. JF - Chemistry of Heterocyclic Compounds. SN - 0009-3122. IS - 6. ER - ...
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Thursday 6th December 2007, 16:15-17:15, Physics Lecture Theatre. Dr. Stuart Warren (Cambridge University) will lead this talk on how saturated oxygen and nitrogen heterocycles can be made by cyclisation-rearrangement chemistry with control of both ring size and stereochemistry. This approach facilitates the use of reactions such as stereoselective aldols and Sharpless AD as well as Heck and metathesis to create open chain compounds with many chiral centres and cyclise them stero- and regiospecifically under mild conditions. Attendance is free of charge - Refreshments provided. Contact: Jeremy Ireland - [email protected] for further information. ...
Heterocyclic compounds. Main article: Heterocyclic compound. The characteristics of the cyclic hydrocarbons are again altered ... Aromatic compounds. Benzene is one of the best-known aromatic compounds as it is one of the simplest and most stable aromatics. ... Aliphatic compounds. Main article: Aliphatic compound. The aliphatic hydrocarbons are subdivided into three groups of ... Converting individual petroleum compounds into different types of compounds by various chemical processes led to organic ...
Orekhov, p. 616 L. Elderfild (1954). Heterocyclic compounds. 3. Moscow. p. 5.. Dewick, pp. 346-376. Hesse, pp. 14-30. Hesse, pp ... Containing more than 4100 known different compounds, it is one of the largest classes of alkaloids. Many of them possess ... about 30 compounds, the most important of which is peduncularine - which contain a monoterpenoid C10 part originating not from ...
Friedel-Crafts alkylation Stolle synthesis Hinsberg reaction Elderfield, R.C. (1952). Heterocyclic Compounds. 3. New York. p. ...
Kenner, G. W.; Todd, Alexander (1957). Elderfield, R.C. (ed.). Heterocyclic Compounds. 6. New York: Wiley. p. 235. Pinner, A. ( ... Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered ... The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6- ... However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic ...
Heterocyclic Compounds. 52. New York, NY: Wiley. ISBN 9780471506560. Archived from the original on 12 May 2018. Horton HR, ... The same compound is therefore represented as the methyl derivative of the compound, which I will arbitrarily endow with the ... It is a planar, unsaturated compound that has the ability to absorb light. Based on 12C/13C isotopic ratios of organic ... Myers RL, Myers RL (2007). The 100 Most Important Chemical Compounds. pp. 92-93. ISBN 9780313337581.[full citation needed] ...
Elderfield, R. C. (ed.). Heterocyclic Compound. 6. New York, NY: John Wiley & Sons. p. 265. Hurd, Charles D.; Webb, Carl N. ( ... "Phosphorus Compounds, Inorganic". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a19 ... which subsequently reacts with electron-rich aromatic compounds to produce aromatic aldehydes upon aqueous work-up. ...
Azasteroid Aporphine Heterocyclic compound India portal Chemistry portal His adviser for master's degree was S. M. Mukherji ... Kessar, Satinder; Kloetzal, Milton C. (1962). "Heterocyclic Compounds. X. Hydrogenated Derivatives of Isoindole and 2- ... Kessar, Satinder; Kloetzal, Milton C. (1962). "Heterocyclic Compounds. X. Hydrogenated Derivatives of Isoindole and 2- ... He is known for his researches in steroidal and heterocyclic chemistry. He is an elected fellow of The World Academy of ...
Heterocyclic Compounds. 1. New York, NY: Wiley. p. 309. Mosher, H. S. (1950). Elderfield, Robert Cooley (ed.). Heterocyclic ... Pyrrole is a heterocyclic aromatic organic compound, a five-membered ring with the formula C4H4NH. It is a colorless volatile ... The Chemistry of Heterocyclic Compounds. 48. Chichester: John Wiley & Sons. p. 351. doi:10.1002/recl.19911100712. ISBN 978-0- ... Heterocyclic Compounds. 1. New York, NY: Wiley. p. 287. Paal, C. (1884), "Ueber die Derivate des Acetophenonacetessigesters und ...
Williamson, T. A. (1957). "The chemistry of quinazoline". In Elderfield, R. C. (ed.). Heterocyclic Compounds. 6. New York: John ...
Heterocyclic Compounds. 1. New York: Wiley. pp. 287 ff. Fischer, Hans (1935). "2,4-Dimethyl-3,5-dicarbethoxypyrrole (2,4- ... Zanetti, C. U.; Levi, E. (1894). "Sintesi di composti pirrolici dai nitrosochetoni" [Synthesis of pyrrole compounds from ... and a compound containing an electron-withdrawing group (e.g. an ester as shown) α to a carbonyl group (2). The mechanism ...
Bergstrom, F. W. (1944). "Heterocyclic Nitrogen Compounds. Part IIA. Hexacyclic Compounds: Pyridine, Quinoline, and ... In the first mechanism 2-amino substituted carbonyl compound 1 and carbonyl compound 2 react in a rate-limiting step to aldol ... adduct 3. This intermediate loses water in an elimination reaction to unsaturated carbonyl compound 4 and then loses water ...
Bergström, F. W. (1944). "Heterocyclic Nitrogen Compounds. Part IIA. Hexacyclic Compounds: Pyridine, Quinoline, and ... β-unsaturated carbonyl compound is prepared in situ from two carbonyl compounds (via an Aldol condensation), the reaction is ... The Doebner-Miller reaction is the organic reaction of an aniline with α,β-unsaturated carbonyl compounds to form quinolines. ... Because α-amino protons are not available in this model compound the reaction is not taken to the fully fledged quinoline. The ...
Bergstrom, F. W. (1944). "Heterocyclic Nitrogen Compounds. Part IIA. Hexacyclic Compounds: Pyridine, Quinoline, and ... is the chemical reaction of isatin with base and a carbonyl compound to yield substituted quinoline-4-carboxylic acids. Several ...
"Heterocyclic Chemistry: Heterocyclic Compounds". Michigan State University, Department of Chemistry. "Market Study: Benzene ( ... He gave the compound the name benzin. In 1836, the French chemist Auguste Laurent named the substance "phène"; this word has ... Many important chemical compounds are derived from benzene by replacing one or more of its hydrogen atoms with another ... The new understanding of benzene, and hence of all aromatic compounds, proved to be so important for both pure and applied ...
Chemistry of Heterocyclic Compounds. 39 (5): 594-597. doi:10.1023/A:1025137914137.. ... Under some conditions the compound will isomerize into succinic anhydride. Upon heating in strongly basic solution (pH > 9) ...
Chemistry of Heterocyclic Compounds. 45 (6): 748-749. doi:10.1007/s10593-009-0318-3. ISSN 0009-3122. Jasiński, Radomir (2009-09 ... Like most nitro compounds, a platinum/palladium catalyzed reaction with hydrogen gas can reduce the nitro group to an amine ... Nitroethylene (also known as nitroethene) is a liquid organic compound with the formula C2H3NO2. It is the simplest nitroalkene ...
3. Reaction of 2,4,6-Tris(trinitromethyl)-1,3,5-triazine with Azides and Hydrazine". Chemistry of Heterocyclic Compounds. 39 (3 ... 2,4,6-Tris(trinitromethyl)-1,3,5-triazine is a chemical compound that is a derivative of triazine first prepared in 1995. It is ...
Ukrainets IV, Bereznyakova NL (April 2012). "Heterocyclic diuretics". Chemistry of Heterocyclic Compounds. 48 (1): 155-65. doi: ...
Chemistry of Heterocyclic Compounds. 50 (4): 583-586. doi:10.1007/s10593-014-1511-6. S2CID 97489753. Shevyrin V, Melkozerov V, ... Synthetic cannabinoid compounds with an indole-3-carboxamide or indazole-3-carboxamide core bearing a N-1-methoxycarbonyl group ... have proved to be much more dangerous than older synthetic cannabinoid compounds previously reported, and have been linked to ...
Chemistry of Heterocyclic Compounds: A Series of Monographs. 59. pp. 169-252. doi:10.1002/0471221902.ch3. ISBN 9780471387268. ... Chemistry of Heterocyclic Compounds. 49 (1): 152-176. doi:10.1007/s10593-013-1236-y. Nyerges, Miklós (2006). "1,7- ... The compounds resulting from this type of electrocyclization have been used as dienes in Diels-Alder reactions to attach ... While dipolarophiles are typically α,β-unsaturated carbonyl compounds, there have been many recent advances in developing new ...
Pēteris Trapencieris (2018). "Edwin Vedejs (1941-2017)". Chemistry of Heterocyclic Compounds. 53 (12): 1373-1374. doi:10.1007/ ...
Mamedov, V. A.; Kalinin, A. A.; Gubaidullin, A. T.; Litvinov, I. A. (2003). Chemistry of Heterocyclic Compounds. 39: 96-100. ... and Chromones from The Chemistry of Heterocyclic Compounds, Weissberger, A. and Taylor, E. C., eds.; Wiley & Sons: New York, ...
W. L. F. Armarego (1967). "Quinazoline". In W. L. F. Armarego (ed.). Chemistry of Heterocyclic Compounds. pp. 11-38. doi: ... W. L. F. Armarego (1967). "Halogenoquinazolines". In W. L. F. Armarego (ed.). Chemistry of Heterocyclic Compounds. pp. 11-38. ... Quinazoline is an organic compound with the formula C8H6N2. It is an aromatic heterocycle with a bicyclic structure consisting ... Quinazolinone Niementowski quinazoline synthesis Armarego, W. L. F. (1963). "Quinazolines". Advances in Heterocyclic Chemistry ...
... is a heterocyclic compound and an organosulfur compound with the formula SC4H6. It is isomeric with the ... Synthesis and Properties (review)". Chemistry of Heterocyclic Compounds. 34: 1101-1122. doi:10.1007/BF02319487. Splivallo, R.; ...
Chemistry of Heterocyclic Compounds. 33 (1): 106-111. doi:10.1007/BF02290756. S2CID 95541398. Hansen, Thomas K.; Jørgensen, ... 2-Bromoethyl ether (or Bis(2-bromoethyl) ether) is an organobromine compound that is also an ether. It is used in the ...
Pesin, V. G.; Sergeev, V. A. (1969). "Research on 2,1,3-thia- and selenadiazole". Chemistry of Heterocyclic Compounds. 3 (5): ... Fedin, E. I.; Todres, Z. V. (1970). "Studies in the field of aromatic heterocycles" (pdf). Chemistry of Heterocyclic Compounds ... Pesin, V. G.; d'Yachenko, E. K. (1969). "Researches on 2,1,3-thia-and selenadiazole". Chemistry of Heterocyclic Compounds. 3: ... The crystal structure of the compound was determined in 1951, when it had the common name piazthiol(e). The extent of the ...
... s are a family of heterocyclic compounds, the parents of which have the formula OC(NH)2(CH)2. Two isomers are ... Chemistry of Heterocyclic Compounds. 51: 395-420. doi:10.1007/s10593-015-1716-3.. ...
... belongs to the series of heterocyclic pnictogen compounds. The naming of cyclic organoarsenic compounds such as arsole ... Tadeusz Marek Krygowski; Michal K. Cyrański; M. Agostinha R. Matos (2009). Aromaticity in Heterocyclic Compounds. Springer. pp ... doi:10.1007/s00214-007-0247-0. Braye, E. H.; Hubel, W.; Caplier, I. (1961). "New Unsaturated Heterocyclic Systems. I". Journal ... Arsole, also called arsenole or arsacyclopentadiene, is an organoarsenic compound with the formula C4H4AsH. It is classified as ...
Chemistry of Heterocyclic Compounds. 51 (3): 275-280. doi:10.1007/s10593-015-1695-4. S2CID 83702396. Karpenko I, Deev S, ...
Yoshina S, Tanaka A, Kuo SC (March 1978). "[Studies on heterocyclic compounds. XXXVI. Synthesis of furo[3,2-c]pyrazole ... Both compounds were tested in various preclinical studies on different animal models and appeared to improve systemic arterial ... To improve the pharmacologic and pharmacokinetic profile an additional 1000 compounds were screened leading to the discovery of ... the search began for novel indazole compounds that were more potent and more specific sGC stimulators. The result was the ...
Organic compounds (proteins, lipids and carbohydrates) contain the majority of the carbon and nitrogen; most of the oxygen and ... These bases are heterocyclic rings containing nitrogen, classified as purines or pyrimidines. Nucleotides also act as coenzymes ... These compounds are made by the assembly and modification of isoprene units donated from the reactive precursors isopentenyl ... The fats are a large group of compounds that contain fatty acids and glycerol; a glycerol molecule attached to three fatty acid ...
doi:10.1002/anie.196401361) Gingrich, H. L.; Baum, J. S. In Oxazoles, Chemistry of Heterocyclic Compounds; Turchi, I. J., Ed.; ... is a mesoionic heterocyclic aromatic chemical compound, with the molecular formula C3H3NO2. The first preparation of a ... Chemical compounds with unusual names Montréalone 5-Oxazolone (tautomer) Sydnone Sydnone imine Lawson, Alexander; Miles, D. H ... Some new mesoionic compounds". Journal of the Chemical Society (Resumed) (0): 2865-2871. doi:10.1039/JR9590002865. Huisgen, R ...
A diazaquinone is a chemical compound that has an heterocyclic aromatic core including two consecutive doubly-bonded nitrogen ...
There are also some heterocyclic and cluster organoaluminium compounds involving Al-N bonds. The industrially most important ... The coordination number of such compounds varies, but generally Al3+ is either six- or four-coordinate. Almost all compounds of ... Uhl, W. (2004). "Organoelement Compounds Possessing Al-Al, Ga-Ga, In-In, and Tl-Tl Single Bonds". Organoelement Compounds ... Although the great majority of aluminium compounds feature Al3+ centers, compounds with lower oxidation states are known and ...
It was named in-line with the Hantzsch-Widman nomenclature and is part of a family of heterocyclic compounds, where it exists ... Oxazoline is a five-membered heterocyclic chemical compound containing one atom each of oxygen and nitrogen. It was likely ... Oxazoline itself has no current applications however compounds containing the ring, which are referred to as oxazolines or ...
Carcinogenic nitrogen compounds. Part XXIV. The synthesis of indole and quinoline compounds from cyclic ketones". J. Chem. Soc ... Some heterocyclic quinols". Journal of the Chemical Society (Resumed): 3916. doi:10.1039/jr9540003916. ISSN 0368-1769. Japp, ...
... s (/ˈpɔːrfərɪn/ POR-fər-in) are a group of heterocyclic macrocycle organic compounds, composed of four modified ... Porphyrin-based compounds are of interest as possible components of molecular electronics and photonics. Synthetic porphyrin ... Representative porphyrins and derivatives Porphin is the simplest porphyrin, a rare compound of theoretical interest. ... Porphycenes showed interesting photophysical behavior and found versatile compound towards the photodynamic therapy. This ...
... gave heterocyclic compounds that were selective as RARβ agonists. The best was the highly potent RARβ agonist oxadiazole 2, ... A key element of this success has been the incorporation of heterocyclic linkers culminating in the discovery of the selective ... Replacing the amide linkage in the novel selective RARα agonist 1 with a series of 5-membered heterocyclic rings, ...
... is mainly used for making 5-membered heterocyclic rings. The C-N distance in methyl isocyanide is very short ... Methyl isocyanide or isocyanomethane is an organic compound and a member of the isocyanide family. This colorless liquid is ...
The reaction may be used to produce carbocyclic or heterocyclic organic compounds with a variety of ring sizes. Chiral ... The high stability of Heck reaction catalysts permits the synthesis of highly strained compounds at elevated temperatures. In ...
... are heterocyclic compounds that are obtained by double dehydration of hexitols such as mannitol and sorbitol ...
It was first synthesized by Curtius and Gloebel in 1888 and was the first compound containing a peptide bond to be studied by X ... conformationally constrained heterocyclic scaffolds in which diversity can be introduced at up to six positions and ... 2,5-Diketopiperazine, also known as piperazine-2,5-dione and as the cyclodipeptide cyclo(Gly-Gly), is an organic compound and ... In food systems, 2,5-diketopiperazines have been shown to be important sensory compounds contributing to the taste of the final ...
N-heterocyclic carbenes (NHCs) have become one of the most important ligands in transition-metal catalysis. The success of ... The versatility of the Sonogashira reaction makes it a widely used reaction in the synthesis of a variety of compounds. One ... In an inverse Sonogashira coupling the reactants are an aryl or vinyl compound and an alkynyl halide. In some cases ... The 1,3-enyne moiety is an important structural unit for biologically active and natural compounds.[citation needed] It can be ...
For his work in the area of synthetic organic chemistry, particularly in synthesis of heterocyclic compounds, Meyers was ...
It is an uncommon heterocyclic compound. They arise by the phosgenation of hydroxamic acids: RC(O)NHOH + COCl2 → RC=NO2CO + 2 ... Middleton, William J. (1983). "1,3,4-Dioxazol-2-ones: a potentially hazardous class of compounds". Journal of Organic Chemistry ...
... heterocyclic compound - heterotroph - heterozygote - Hfr cell - Hill reaction - His tag - histamine H1 receptor - histamine H2 ... alicyclic compound - aliphatic compound - alkali - Allosteric site - allostery - allotrope - allotropy - alpha adrenergic ... List of compounds - list of gene families - locus - luminescent protein - lymphocyte homing receptor - Lysine - lysis - lysis ... Organic compound - Organic nomenclature - Organic reaction - Organism - osmosis - osteocalcin - outer hair cell - outline of ...
Heme is a heterocyclic macrocycle ring shaped tetradentate ligand. It is an important molecule in red blood cells. Chlorophyll ... unlike nitrogen compounds which rapidly racemize. If all the feet of the tripod are symmetrical and identical to each other, ... Stereochemistry of Optically Active Transition Metal Compounds. p. 401. doi:10.1021/bk-1980-0119.ch021. "Coordination Chemistry ...
... are organic compounds containing the aziridine functional group, a three-membered heterocycle with one amine (-NR-) ... Gilchrist, T.L. (1987). Heterocyclic chemistry. ISBN 978-0-582-01421-3. Epoxides and Aziridines - A Mini Review Albert Padwa ... A banana bond model explains bonding in such compounds. Aziridine is less basic than acyclic aliphatic amines, with a pKa of ... The International Agency for Research on Cancer (IARC) classifies aziridine compounds as possibly carcinogenic to humans (IARC ...
... is the heterocyclic compound consisting of fused benzene and furan rings. This colourless liquid is a component of ... Benzofuran is the "parent" of many related compounds with more complex structures. For example, psoralen is a benzofuran ... CS1 maint: discouraged parameter (link) Bowden, K.; Battah, S. (1998). "Reactions of Carbonyl Compounds in Basic Solutions. ...
... is a theoretical heterocyclic organic compound, a five-membered ring with the formula C4H4BiH. It is classified as a ... The unsubstituted compound has not been isolated due to the high energy of the Bi-H bond. Substituted derivatives, which have ... Bismoles can be used to form ferrocene-like sandwich compounds. Organobismuth chemistry Suzuki, Hitomi; Komatsu, Naoki; Ogawa, ...
The heterocyclic NH groups are more reactive than amino groups, and their secondary chloramines are able to donate the chlorine ... The resulting compound is a chlorohydrin. The polar chlorine disrupts lipid bilayers and could increase permeability. When ... In similar manner, TMP with only a heterocyclic NH group that is reactive with HClO is the second-most reactive. AMP and CMP, ... Its compounds will be called hypochlorites.) Unangst, P. C. "Hypochlorous Acid" in Encyclopedia of Reagents for Organic ...
Like other difunctional benzene derivatives, catechol readily condenses to form heterocyclic compounds. Cyclic esters are ... This colorless compound occurs naturally in trace amounts. It was first discovered by destructive distillation of the plant ... A Guide to IUPAC Nomenclature of Organic Compounds (Recommendations 1993) R-5.5.1.1 Alcohols and phenols. Panico, R.; Powell, W ... Catechol (/ˈkætɪtʃɒl/ or /ˈkætɪkɒl/), also known as pyrocatechol or 1,2-dihydroxybenzene, is a toxic organic compound with the ...
... , or more formally known as bis(1,2,4-oxadiazole)bis(methylene) dinitrate, is a nitrated heterocyclic compound of ... these compounds are poised to release a large volume of very stable N2. It is a "melt-cast" explosive material that is ...
"Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds". Bioorganic & Medicinal ... A New Skeletal Basis for Antiplasmodial Compounds". Bioorganic & Medicinal Chemistry Letters. 13 (16): 2769-2772. doi:10.1016/ ... This compound shows an anti-chagasic activity. del Olmo, Esther; Armas, Marlon Garcia; Ybarra, Ma Inèss; Lopez, José Luis; ...
... , also known as tribulin, is an organic compound derived from indole with formula C8H5NO2. The compound was first ... Popp, Prank D. (1975). "The Chemistry of Isatin". Advances in Heterocyclic Chemistry Volume 18. Advances in Heterocyclic ... This represent the indigo pigment's red component and a highly effective cytotoxic compound. Reduction of the non-amide ... A direct route to -arylisatoic anhydrides". Journal of Heterocyclic Chemistry. 24 (5): 1249-1251. doi:10.1002/jhet.5570240503. ...
... is a seven-membered heterocyclic compound with two nitrogen atoms (e.g., in ring positions 1 and 2). Types include: 1 ...
Formyl compounds. Part II". J. Chem. Soc.: 1843. doi:10.1039/jr9580001843. ^ Campaigne, E.; Thompson, R. L.; Van Werth, J. E. ( ... 1959). "Some Heterocyclic Aldehyde Thiosemicarbazones Possing Anti-viral Activity". J. Med. Chem. 1 (6): 577. doi:10.1021/ ...
... as an extracted compound has been shown capable of killing Escherichia coli O157:H7 and Listeria monocytogenes, with ... "Acrolein contributes strongly to antimicrobial and heterocyclic amine transformation activities of reuterin". Scientific ... The name reuterin is derived from Lactobacillus reuteri, which produces the compound biosynthetically from glycerol as a broad- ... Reuterin is a potent antimicrobial compound produced by Lactobacillus reuteri. It is an intermediate in the metabolism of ...
Other compounds with related structure include terbinafine and NB598. Synthesis of amino acids β,γ-unsaturated, N-substituted ... Apart from vinyl boronic acids, aryl boronic acids and other heterocyclic derivatives can also be used in Petasis ... Petasis, N.A. (2005). "Multicomponent Reactions with Organoboron Compounds". In Zhu, J.; Bienayme, H. (eds.). Multicomponent ... γ-unsaturated compounds. One of the most attractive features of the Petasis reaction is its use of boronic acids as a ...
The transformation of a normal cell into cancer is akin to a chain reaction caused by initial errors, which compound into more ... Zheng W, Lee SA (2009). "Well-done meat intake, heterocyclic amine exposure, and cancer risk". Nutrition and Cancer. 61 (4): ... The errors that cause cancer are self-amplifying and compounding, for example: A mutation in the error-correcting machinery of ... refers to compounds used instead of conventional medicine. Most complementary and alternative medicines for cancer have not ...
Heterocyclic compounds are pervasive in many areas of life sciences and technology.[9] Many drugs are heterocyclic compounds.[ ... Although heterocyclic chemical compounds may be inorganic compounds or organic compounds, most contain at least one carbon. ... A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of ... IUPAC recommends the Hantzsch-Widman nomenclature for naming heterocyclic compounds. Heterocyclic compounds can be usefully ...
Many drugs are heterocyclic compounds. IUPAC Gold Book heterocyclic compounds Thomas L. Gilchrist "Heterocyclic Chemistry" 3rd ... highlighting the role of heterocyclic compounds (purines and pyrimidines) in the genetic code. Heterocyclic compounds are ... A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of ... Examples of heterocyclic compounds include all of the nucleic acids, the majority of drugs, most biomass (cellulose and related ...
... heterocyclic compound (CHEBI:5686). inorganic heterocyclic compound (CHEBI:33596) is a heterocyclic compound (CHEBI:5686). N-(3 ... heterocyclic compound (CHEBI:5686). organic heterocyclic compound (CHEBI:24532) is a heterocyclic compound (CHEBI:5686). ... heterocyclic compound (CHEBI:5686). heterobicyclic compound (CHEBI:33672) is a heterocyclic compound (CHEBI:5686). heterocyclic ... heterocyclic compound (CHEBI:5686). heteromonocyclic compound (CHEBI:33670) is a heterocyclic compound (CHEBI:5686). ...
... and biological activity of heterocyclic compounds including natural products. The ... ... Chemistry of Heterocyclic Compounds publishes articles, letters to the Editor, reviews, and minireviews on the synthesis, ... Chemistry of Heterocyclic Compounds. Editor-in-Chief: I. Kalvinsh. ISSN: 0009-3122 (print version). ISSN: 1573-8353 (electronic ... and biological activity of heterocyclic compounds including natural products. The journal covers investigations in heterocyclic ...
Polyfluorinated heterocyclic compounds. VIL Synthesis of 4,5,6,7-tetrafluorotryptophan; 4,5,6,7-tetrafluoroheteroauxin; and 4,5 ...
Heterocyclic compounds in which a 4-thia-1-aza-bicyclo[3.2.0] ring system is substituted at the 6-position with a carboxylic ... Heterocyclic compounds in which a 4-thia-1-azabicyclo[3.2.0]heptane ring system with a double bond is in between positions 2 ... Heterocyclic compounds in which a 4-thia-1-azabicyclo[3.2.0]heptane ring system with a double bond is in between positions 2 ... Heterocyclic compounds in which a 4-thia-1-azabicyclo[3.2.0]heptane ring system with a double bond is in between positions 2 ...
Aromaticity denotes the significant stabilization of a ring compound by a system of alternating single and double bonds-called ... More About Heterocyclic compound. 1 reference found in Britannica articles. Assorted References. *organosulfur compounds* In ... Physical properties of heterocyclic compounds*Melting and boiling points. *Ultraviolet, infrared, nuclear magnetic resonance, ... Physical properties of heterocyclic compounds. Physical properties are important as criteria for judging the purity of ...
... one or more of the ring carbon atoms in the molecules of a carbocyclic compound with a heteroatom gives a heterocyclic compound ... Comparison with carbocyclic compounds: The molecules of organic chemical compounds are built up from a framework or backbone of ... When the ends of the chains are joined together into a ring, cyclic compounds result; such substances often are referred to as ... Nomenclature of heterocyclic compounds. Naming heterocyclic compounds is complicated because of the existence of many common ...
For polycyclic heterocyclic compounds containing one or more heterocyclic nuclei of aromatic or nonaromatic character, together ... For polycyclic heterocyclic compounds containing one or more heterocyclic nuclei of aromatic or nonaromatic character, together ... The types of systems are more numerous than in the case of monocyclic heterocyclic compounds : the electroactive group may be ... Zuman P. (1967) Effects of Substituents in Polycyclic Heterocyclic Compounds. In: Substituent Effects in Organic Polarography. ...
... β-unsaturated compound) is a superb method for the construction of 1,4-dicarbonyl compounds bearing quaternary stereocenters ( ... Rovis has demonstrated that triazolium salt (667080) in the presence of a base can act as an N-heterocyclic carbene ...
The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated gene data at MGI are provided in Term Detail reports.
... compounds of Formula (II): compounds of Formula (III): and compounds of Formula (IV): compositions comprising these compounds ... NOVEL HETEROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS. The present invention relates to novel compounds of the general formula (I) ... NITROGENATED HETEROCYCLIC AMIDE COMPOUND, AND USE THEREOF FOR MEDICAL PURPOSES. The present invention provides a compound which ... HETEROCYCLIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF. The present application is directed to compounds of Formula (I ...
The compounds are substituted derivatives of 6p-N-heterocyclic naltrexamine (NAP) and are used in the trea... ... The compounds are exemplified by compounds of the Formula I. The method comprises providing in combinat... ... The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote ... The compounds are used in the treatment of opioi... WO/2017/184979A1 N-DEMETHYLATION OF MORPHINAN ALKALOIDS. The present ...
Treatment of the latter compound 8 with aldehydes in boiling ethanol in the presence of acetic acid afforded the corresponding ... Treatment of 3 with hydrazine hydrate in ethanol afforded amino imino compound 4. Reaction of 4 with diethyl dicarbonate at ... Utility of Styrylpyrazoloformimidate in the Synthesis of Fused Heterocyclic Compounds () Hamdi M. Hassaneen*, Zakaria Ahmed ... Hassaneen, H. and Gomaa, Z. (2015) Utility of Styrylpyrazoloformimidate in the Synthesis of Fused Heterocyclic Compounds. ...
T 1066/01 (Anti-inflammatory heterocyclic compounds/BOEHRINGER INGELHEIM) of 1.6.2005. European Case Law Identifier:. ECLI:EP: ... EPC if it does not result in singling out any hitherto not specifically mentioned individual compound or group of compounds, ... 5. Use of a compound in accordance with any of claims 1, 2, 3 or 4 for the manufacture of a pharmaceutical composition for the ... 8. Use of a compound in accordance with any of claims 1, 2, 3 or 4 for the manufacture of a pharmaceutical composition for the ...
ACHESON, R. M. - An Introduction to the Chemistry of Heterocyclic Compounds. Interscience Publishers. 1962. Hard Cover, 9.25 x ... A concise account of the more important properties and chemical reactions of the basic heterocyclic systems of organic ...
Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds. ... Disclosed compounds of formula (I) ##STR00001## which inhibit production of cytokines involved in inflammatory processes and ... Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.. ... 3. The method according to claim 2 wherein for the compound of the formula (I) Ar.sup.1 is chosen from (i) and (ii); R.sup.5 is ...
Heterocyclic azo compounds are well known for their use as antineoplastics [32], antidiabetics [33], antiseptics [34], and ... Compound 7 exhibited high degree of antibacterial activity against Gram-positive bacteria (SA). Compounds 3c and 7 have ... M. E. Azab, M. M. Youssef, and E. A. El-Bordany, "synthesis and antibacterial evaluation of novel heterocyclic compounds ... A facile and convenient synthesis of new heterocyclic compounds containing a sulfamoyl moiety suitable for use as antimicrobial ...
The present invention provides compounds of formula I, ,p,,chemistry id=CHEM-US-00001 num=00001,,img id=EMI-C00001 he= ... to give compounds of formula II. Compound II can be converted into a compound of formula I according to the methods of Scheme 1 ... provides compounds of formula II, wherein R2 is an oxetane. Compound II can be converted into a compound of formula I according ... Carbocyclic- And Heterocyclic-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds ...
heterocyclic compounds. heterocyclic. compounds. Prior art date. 1985-06-18. Application number. IE137786A. Other versions. ... C07D-HETEROCYCLIC COMPOUNDS * C07D409/00-Heterocyclic compounds containing two or more hetero rings, at least one ring having ... C07D-HETEROCYCLIC COMPOUNDS * C07D401/00-Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as ... C07D-HETEROCYCLIC COMPOUNDS * C07D401/00-Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as ...
The inhibition effect of the compounds was evaluated against bacteria, molds and yeasts; the activities were expressed as the ... Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds. Bianca Furdui 1. ... "Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds." Molecules 19, no. 8: ... Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds. Molecules 2014, 19, ...
The Chemistry of Heterocyclic Compounds: Small Ring Heterocycles, Part 3, Volume 42 als Download. Jetzt eBook herunterladen & ... The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. ... The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. ... The Chemistry of Heterocyclic Compounds: Small Ring Heterocycles, Part 3, Volume 42 (eBook / PDF). ...
... small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for ... small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for ... EN) HETEROCYCLIC KETONE AND THIOESTER COMPOUNDS AND USES. (FR) COMPOSES DE CETONE ET DE THIOESTER HETEROCYCLIQUES ET ... Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ...
A class of heterocyclic compounds that include four or more fused rings. Both aromatic or non-aromatic ring structures are ... Heterocyclic Compounds, 4 or More Rings. Known as: 4-ring or more heterocyclic compounds, Heterocyclic Compounds with Four or ... Heterocyclic Cpds, 4 or More Rings Expand. A class of heterocyclic compounds that include four or more fused rings. Both ...
Description: Heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline ring-system, not further fused, ...
108 introduction of heterocyclic compounds manufacturers & introduction of heterocyclic compounds suppliers from China. ... Buy introduction of heterocyclic compounds from introduction of heterocyclic compounds manufacturer, ... reactions of heterocyclic compounds uses of heterocyclic compounds applications of heterocyclic compounds importance of ... introduction of heterocyclic compounds. All introduction of heterocyclic compounds wholesalers & introduction of heterocyclic ...
... are a class of compounds that consist of carbon atoms and non-carbon atoms altogether forming a cyclic ... heterocyclic compounds can be divided into single-heterocyclic compounds and fused heterocyclic compounds. E.g., furan, ... heterocyclic compounds can be divided into five-membered compounds and six-membered heterocyclic compounds. E.g., furan, ... are single-heterocyclic compounds and indole, quinoline, dibenzofuran, purines, etc. are fused heterocyclic compounds. ...
Keeping this in mind our group has been making sustained efforts in developing heterocyclic compounds as noble leads because ... Azam A., Agarwal S.M. (2015) Heterocyclic Lead Compounds Against Amebiasis. In: Nozaki T., Bhattacharya A. (eds) Amebiasis. ... Cerecetto H, Gonzalez M (2008) Anti-T. cruzi agents: our experience in the evaluation of more than five hundred compounds. Mini ... Al-Masri AT, Saadeh HA, Mosleh IM, Mubarak MS (2012) Synthesis of new compounds derived from metronidazole and amino acids and ...
ETDEWEB / Search Results / On the radioprotective properties of heterocyclic nitrogenous compounds; Etude des proprietes ... Rinaldi, R, and Bernard, Y. On the radioprotective properties of heterocyclic nitrogenous compounds; Etude des proprietes ... Rinaldi, R, & Bernard, Y. On the radioprotective properties of heterocyclic nitrogenous compounds; Etude des proprietes ... Continuing their study of the possible radioprotective properties of heterocyclic nitrogenous compounds, the authors study ...
Indole is an aromatic heterocyclic organic compound. It has a bicyclic structure, consisting of a six-membered benzene ring ... Other indolic compounds include the plant hormone Auxin (indolyl-3-acetic acid, IAA), the anti-inflammatory drug indomethacin, ... The indole structure can be found in many organic compounds like the amino acid tryptophan and in tryptophan-containing protein ... and for some compounds the synthetic precursors for) the tryptophan-derived tryptamine alkaloids like the neurotransmitter ...
  • With heterocycles containing five atoms, the unsaturated compounds are frequently more stable because of aromaticity . (wikipedia.org)
  • Heterocycles incorporating elements other than C, H, halogen, N, O, S, Se or Te are classified in subclass C07F , but only if the metal-containing compound has a metal carbon bond or if the metal is attached to at least two different ligands. (uspto.gov)
  • Heterocyclic chemistry is the branch of organic chemistry dealing with the synthesis, properties, and applications of these heterocycles. (wikipedia.org)
  • More than half of known compounds are heterocycles. (wikipedia.org)
  • Analogs of the previously mentioned heterocycles for this third family of compounds are acridine, dibenzothiophene, carbazole, and dibenzofuran, respectively. (wikipedia.org)
  • Many natural soils contain a broad spectrum of organic compounds, including amino acids, amino sugars, and nitrogen heterocycles, particularly under conditions in which bacterial activity is inhibited. (plantcell.org)
  • Heterocyclic chemistry is the chemistry branch dealing exclusively with synthesis, properties, and applications of heterocycles. (en-academic.com)
  • Important drugs (80% of top-selling drugs contain heterocycles: benzodiazepines, quinine, penicillin, etc.) * and even Food (sugar has heterocyclic rings too! (asmolgam.com)
  • A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of its ring(s). [1] Heterocyclic chemistry is the branch of chemistry dealing with the synthesis, properties and applications of these heterocycles . (infogalactic.com)
  • The course of Chemistry of Heterocyclic Compounds is a preparative course to the course of Medicinal Chemistry I. Therefore the aim of this course is to study the main heterocycles (monocyclic, biciclic and policiclic) as basic components of pharmacologically active compounds. (uniss.it)
  • Nitrogen-containing heterocycles have been used as pharmaceutical compounds for centuries. (getnews.info)
  • Heterocyclic compounds have great diversity in chemical and physical properties, and that's why the heterocycles can be widely used in the fields of pharmacy, agrochemistry, electronics, and the like. (getnews.info)
  • Therefore, the study of heterocyclic chemistry focuses especially on unsaturated derivatives, and the preponderance of work and applications involves unstrained 5- and 6-membered rings. (wikipedia.org)
  • Other heterocyclic compounds can be envisioned similarly as derivatives of cyclopentane by substitution with other heteroatoms or of other carbocyclic compounds by substitution with nitrogen or other heteroatoms. (britannica.com)
  • The present disclosure refers to 10-(di(phenyl)methyl)-4- hydroxy-8,9,9a,10-tetrahydro-7H-pyrrolo[1';2':4,5]pyrazino[1 ,2- b]pyridazine-3,5-dione derivatives and related compounds of Formula (A) as inhibitors of the orthomyxovirus replic. (sumobrain.com)
  • The present invention relates to deuterated derivatives of 9-(2,5-difluorophenethyl)-4- ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one having pharmacological activity, to processes of preparation of such compounds, to pharmaceutic. (sumobrain.com)
  • The compounds are substituted derivatives of 6p-N-heterocyclic naltrexamine (NAP) and are used in the trea. (sumobrain.com)
  • Continuing their study of the possible radioprotective properties of heterocyclic nitrogenous compounds, the authors study certain derivatives of imidazole and other compounds of similar structure. (osti.gov)
  • Etude des proprietes radioprotectrices de composes heterocycliques azotes} author = {Rinaldi, R, and Bernard, Y} abstractNote = {Continuing their study of the possible radioprotective properties of heterocyclic nitrogenous compounds, the authors study certain derivatives of imidazole and other compounds of similar structure. (osti.gov)
  • Heterocyclic compounds with nitrogen only hetero-atom(s) containing an unfused imidazole ring excluding hydantoin and its derivatives. (statista.com)
  • Benzo[cicinnoline and its derivatives are important heterocyclic compounds with antirheumatoid, as well as antimitotic properties. (freethesaurus.com)
  • Buy Thiophene and Its Derivatives, Part 2 (The Chemistry of Heterocyclic Compounds, Vol. 44) on Amazon.com ✓ FREE SHIPPING on qualified orders. (plancul-belge.be)
  • This invention has as its purpose the provision of new compounds or new derivatives of condensed Pyh and exactlyonce heterocyclic compounds with low toxicity and high antitumor activity. (russianpatents.com)
  • A cyclic compound having as ring members atoms of at least two different elements. (ebi.ac.uk)
  • Aromaticity denotes the significant stabilization of a ring compound by a system of alternating single and double bonds-called a cyclic conjugated system -in which six π electrons generally participate. (britannica.com)
  • A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of its ring(s). (wikipedia.org)
  • Heterocyclic compounds are a class of compounds that consist of carbon atoms and non-carbon atoms altogether forming a cyclic skeletal structure. (chemicalbook.com)
  • Lactones, lactams, cyclic ethers that we've already learned are heterocyclic compounds. (chemicalbook.com)
  • The only exception to this requirement is that the compounds may contain metal atoms, but only as the cations of heterocyclic organic acid salts, alcoholates, phenolates or mercaptides, or as chelating atoms, e.g. in porphyrins. (uspto.gov)
  • In six-membered heteroaromatic rings, the heteroatoms (usually nitrogen) are pyridine-like-for example, the compounds pyrimidine , which contains two nitrogen atoms, and 1,2,4-triazine, which contains three nitrogen atoms. (britannica.com)
  • The molecules of organic chemical compounds are built up from a framework or backbone of carbon atoms to which are attached hydrogen (H), oxygen, or other heteroatoms. (britannica.com)
  • Substitution of one or more of the ring carbon atoms in the molecules of a carbocyclic compound with a heteroatom gives a heterocyclic compound. (britannica.com)
  • When one of the carbon atoms of cyclopentane is replaced with an atom of nitrogen, the compound pyrrolidine, a chemical relative of pyrrole , is produced. (britannica.com)
  • Nonaromatic unsaturated compounds are highly reactive-that is, they readily undergo additions of atoms or groups of atoms to the carbon atoms of their double bonds, giving each carbon four substituents. (britannica.com)
  • According to the number of hetero atoms, five-membered compounds and six-membered heterocyclic compounds can be divided into one-hetero-atom-containing heterocyclic compounds and two-hetero-atom-containing and several-hetero-atom-containing heterocyclic compounds. (chemicalbook.com)
  • purine, comprising more than two hetero atoms, is a several-hetero-atom-containing heterocyclic compound. (chemicalbook.com)
  • The Title "The Chemistry of Heterocyclic Compounds, Heterocyclic Systems with Bridgehead Nitrogen Atoms" is written by W.L. Mosby. (printsasia.com)
  • The Chemistry of Heterocyclic Compounds, Heterocyclic Systems with Bridgehead Nitrogen Atoms is currently Available with us. (printsasia.com)
  • heterocyclic compound - Any of a class of organic compounds whose molecules contain one or more rings of atoms with at least one atom (the heteroatom) being an element other than carbon, most frequently oxygen, nitrogen, or sulfur. (en-academic.com)
  • Heterocyclic compounds are organic compounds that contain a ring structure containing atoms in addition to carbon, such as sulfur, oxygen or nitrogen, as part of the ring. (primaryinfo.com)
  • Volume 20 deals with heterocyclic compounds which contain only one nitrogen atom as the ring-heteroatom and which bear no functional groups on the ring-carbon atoms. (bookdepository.com)
  • The asymmetrical carbon atoms contained in the compounds of formula (I) can independently from one other have the R, S or RS configuration, and a subject of the invention is also therefore, the compounds of formula (I) presented in the form of pure enantiomers or pure diastereoisomers or in the form of a mixture of enantiomers in particular racemates, or diastereoisomer mixtures. (allindianpatents.com)
  • Organic chemistry is the chemistry subdiscipline for the scientific study of structure, properties, and reactions of organic compounds and organic materials (materials that contain carbon atoms ). (wikipedia.org)
  • In contrast, the rings of homocyclic compounds consist entirely of atoms of the same element. (infogalactic.com)
  • Heterocyclic - denoting a compound whose molecule contains a ring of atoms of at least two elements (one of which is generally carbon). (larochelleairport.net)
  • The most common and also the most important heterocyclic compounds are that with five-membered or six-membered heterocyclic ring and their fused heterocyclic compounds. (chemicalbook.com)
  • Therefore, according to the size of the ring, heterocyclic compounds can be divided into five-membered compounds and six-membered heterocyclic compounds. (chemicalbook.com)
  • Drugs containing an aromatic five-membered nitrogen heterocyclic compound include cholesterol-lowering Atorvastatin, anti-inflammatory Celecoxib, anti-ulcer Cimetidine, antifungal Fluconazole, and antihypertensive Losartan. (getnews.info)
  • The 5-membered ring compounds containing two heteroatoms, at least one of which is nitrogen, are collectively called the azoles . (wikipedia.org)
  • A large group of 5-membered ring compounds with three heteroatoms also exists. (wikipedia.org)
  • Six-membered heteroaromatic compounds cannot normally contain pyrrolelike heteroatoms. (britannica.com)
  • The hypothetical compound with six nitrogen heteroatoms would be hexazine. (wikipedia.org)
  • Compounds with one heteroatom include: Those with two heteroatoms include: Borazocine is an eight-membered ring with four nitrogen heteroatoms and four boron heteroatoms. (wikipedia.org)
  • Systems with two heteroatoms are usually constructed from two compounds of which one contains both heteroatoms as nucleophiles and the other contains two electrophilic groups. (taylorfrancis.com)
  • A large group of 5-membered ring compounds with two heteroatoms are collectively called the azole s. (en-academic.com)
  • With 5-heteroatoms, the compound may be considered inorganic rather than heterocyclic. (infogalactic.com)
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  • and pyridine is a typical heterocyclic aromatic, or heteroaromatic, substance. (britannica.com)
  • Comparability and repeatability of methods for estimating the dietary intake of the heterocyclic amine contaminant 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP). (cdc.gov)
  • 2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist. (echemi.com)
  • Likewise, the compounds with two benzene rings fused to the central heterocycle are carbazole, acridine, and dibenzoazepine. (wikipedia.org)
  • The main direction of the group's research is the development of new approaches to the synthesis of heterocyclic compounds, as well as the application of these Chemistry of Heterocyclic Compounds - CRC Press Book Dec 22, 2014 This book discusses the structure, synthesis, and reactivity of heterocyclic compounds. (plancul-belge.be)
  • Paal-Knorr Reaction in the Synthesis of Heterocyclic Compounds. (plancul-belge.be)
  • Many heterocyclic compounds, including some amines , are carcinogenic . (en-academic.com)
  • Some heterocyclic amines (HCAs) found in cooked meat are known carcinogen s. (en-academic.com)
  • For example, heterocyclic amines are the carcinogenic chemicals formed from the cooking of muscle meats such as beef , pork , fowl , and fish . (en-academic.com)
  • Some heterocyclic amines (HCAs) found in cooked meat are known carcinogens. (primaryinfo.com)
  • Pentazole is the all nitrogen heteroatom unsaturated compound. (infogalactic.com)
  • Aromatic heterocyclic compounds are those which have a heteroatom in the ring and acting in a manner similar to benzene in some properties. (getnews.info)
  • Although heterocyclic chemical compounds may be inorganic compounds or organic compounds, most contain at least one carbon. (wikipedia.org)
  • Biocidal, pest attractant, or plant growth regulatory activity of chemical compounds or preparations is further classified in subclass A01P (this subclass does only exist in IPC).Therapeutic activity of chemical compounds is further classified in subclass A61P . (uspto.gov)
  • The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. (sumobrain.com)
  • This invention relates to novel oxazoles and thiazoles, to processes for the preparation thereof and to pharmaceutical compositions containing such compounds. (passivity.us)
  • The invention provides PDE9-inhibiting compounds of Formula (I), ##STR00001## and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , A, and n are as defined herein. (patentsencyclopedia.com)
  • Pharmaceutical compositions containing the compounds of Formula I, and uses thereof in treating neurodegenerative and cognitive disorders, such as Alzheimer's disease and schizophrenia, are also provided. (patentsencyclopedia.com)
  • or b) a pharmaceutical composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle, carrier or diluent. (patentsencyclopedia.com)
  • Journal of Heterocyclic Chemistry, 17, 1713-1717. (scirp.org)
  • Journal of Heterocyclic Chemistry, 17, 833-854. (scirp.org)
  • Journal of Heterocyclic Chemistry, 24, 1665-1668. (scirp.org)
  • Compounds, compositions and methods are provided for the inhibition of GBP1. (sumobrain.com)
  • Provided herein are oxa- and aza-tricyclic 4-pyridone-3-carboxylic acid compounds, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for inhibiting HBsAg secretion and HBV DNA production, and fo. (sumobrain.com)
  • The invention provides compounds, compositions, and methods for treating pain. (sumobrain.com)
  • The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to the opioid oxymorphone, in a manner that substantially decreases or deters the potential for opioid abuse, addiction, illicit and illegal. (sumobrain.com)
  • The present invention relates to heterocyclic compounds, their compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. (justia.com)
  • The invention also relates to pharmaceutical compositions containing such compounds in treating diseases disorders associated with calcium release-activated calcium (CRAC) channel modulators. (patentsencyclopedia.com)
  • Crosslinking has been produced in products from ethylenically unsaturated compositions such as acrylic compositions (e.g. a methyl methacrylate composition) by incorporation of from about 1 to about 10 percent by weight of a polyacrylic substituted compound as a crosslinking agent. (google.com)
  • The purpose of this invention is the provision of a method of obtaining these compounds and pharmaceutical compositions containing these compounds as active ingredient. (russianpatents.com)
  • Synthesis of pyrimidine nucleus from 1,3-dicarbonyl compounds (β-diketones + amidine, β-diketones + guanidine). (uniss.it)
  • Several heterocyclic compounds involved in biology include nucleic acids (nitrogen-containing purine and pyrimidine bases in DNA), vitamins (thiamine B1, riboflavin B2, nicotinamide B3), essential amino acids (proline, histidine and tryptophan) and heme (haemoglobin). (getnews.info)
  • The simplest organic compounds are the hydrocarbons , compounds of carbon and hydrogen only. (britannica.com)
  • A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. (umassmed.edu)
  • Nitro-carbon heterocyclic structures are found in various therapeutic agents, including numerous antihistamines, as well as antiseptic, antiarrythmic, antirheumatic, antibiotic and other pharmaceutical compounds. (primaryinfo.com)
  • The bonding patterns of carbon, with its valence of four-formal single, double, and triple bonds, plus structures with delocalized electrons-make the array of organic compounds structurally diverse, and their range of applications enormous. (wikipedia.org)
  • Heterocyclic compounds are presumably the largest class of organic compounds, obtaining great diversity in chemical and physical properties. (plancul-belge.be)
  • Sep 1, 2012 In general, the physical and chemical properties of heterocyclic compounds are best understood by comparing them with ordinary organic Chemistry of heterocyclic compounds . (plancul-belge.be)
  • This book covers the general properties of heterocyclic compounds and methods for their preparation to use in applications of green chemistry. (routledge.com)
  • All introduction of heterocyclic compounds wholesalers & introduction of heterocyclic compounds manufacturers come from members. (hfcletter.com)
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  • A possibility of introduction of heterocyclic ortho -aminoketones into promoted by TMSCI Friedländer reaction with a wide set of α-methylenecarbonyl compounds was studied. (enamine.net)
  • Various methods based on energetic, structural, and magnetic criteria have been widely used to measure the aromaticity of carbocyclic compounds. (britannica.com)
  • This chapter will mainly discuss heterocyclic compounds with relatively stable ring system and with a certain degree of aromaticity, also known as aromatic heterocyclic compound. (chemicalbook.com)
  • Once you get the basics we'll look at the trickier questions including fused rings, anion and cation aromaticity followed by heterocyclic compounds. (leah4sci.com)
  • All aromaticity in heterocyclic compounds wholesalers & aromaticity in heterocyclic compounds manufacturers come from members. (tjskl.org.cn)
  • The indole structure can be found in many organic compounds like the amino acid tryptophan and in tryptophan-containing protein, in alkaloids, and in pigments. (bayho.com)
  • Skatole - a mildly toxic white crystalline organic compound belonging to the indole family. (larochelleairport.net)
  • Three representations of an organic compound, 5α-Dihydroprogesterone (5α-DHP), a steroid hormone . (wikipedia.org)
  • What is heterocyclic organic compound? (getnews.info)
  • Cover compounds containing one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system, with or without other non-condensed hetero rings. (uspto.gov)
  • such substances often are referred to as carbocyclic or alicyclic compounds. (britannica.com)
  • Names in italics are retained by IUPAC and they do not follow the Hantzsch-Widman nomenclature Heterocyclic rings systems that are formally derived by fusion with other rings, either carbocyclic or heterocyclic, have a variety of common and systematic names. (wikipedia.org)
  • In this thesis, Anmber of heterocylic compound with five and six memberd, Such as substituted imidazole, triazin and thiazolidine. (iraqjournals.com)
  • From the reaction of compound(1) with phenyl thiourea attended imidazole -2-thione(7). (iraqjournals.com)
  • Assay 99% 4-Aminopyridine Heterocyclic CAS 504-24-5 EINECS 207-987-9 Avitrol 200 Product Description 4- aminopyridine, white crystal. (phrmg.org)
  • The purpose of the present invention is to provide a compound that is effective as a prophylactic agent or a therapeutic agent for various diseases and symptoms associated with the orexin receptor, as well as to provide a medical usage t. (sumobrain.com)
  • The present invention relates to novel compounds and probes which have a common chemical structure necessary to obtain potent inhibitory activity against KLK4. (patents.com)
  • The present invention is directed to a multi-sensor array compound including at least three chromophores, at least one receptor and an anchor. (patents.com)
  • The present invention provides a compound and a pharmaceutical composition for neuropsychological disorders or malignant tumors, the use of the compound and the. (patents.com)
  • An object of the present invention is to provide a compound and pharmaceutical composition showing superior stability and/or solubility, etc. and having superior FLT3 inhibitory activity. (patents.com)
  • The present invention is directed to certain amides and heterocyclic compounds. (justia.com)
  • The present invention also relates to uses of these compounds to treat several diseases including autoimmune disorders, cardiovascular disorders, inflammation, central nervous system disorders, arterial thrombotic disorders, fibrotic disorders, glaucoma, and neoplastic disorders. (justia.com)
  • The present invention relates to a novel process for preparing known heterocyclic compounds by alkylation of suitable precursors. (allindianpatents.com)
  • As a result, they have found that the new condensed Pyh and exactlyonce heterocyclic compounds having oralloy structure in their molecule, have high antitumor activity and low toxicity, which is the completion of the present invention. (russianpatents.com)
  • The invention relates to novel condensed polycyclic heterocyclic compounds of the formula I and the way they are received. (russianpatents.com)
  • According to the form of the ring in the molecule, heterocyclic compounds can be divided into single-heterocyclic compounds and fused heterocyclic compounds. (chemicalbook.com)
  • Heterocyclic compounds are organic compounds that contain a heterocyclic structure in the molecule and are the largest number of organic compounds. (echemi.com)
  • Salts, chelates, alcoholates (except Ti/Zr), phenates involving a single ligand are classified as the parent compound (metal containing porphyrin C07D 487/22 ). (uspto.gov)
  • Azabicyclic heterocyclic Compound of general formula (I), or one of its salts with a base or an acid: in which R1, R2, R3, X, A and n are as herein described in the specification and claims. (allindianpatents.com)
  • A subject of the invention is also the salts of these compounds which can be obtained with bases or organic or inorganic acids, together with the internal salts in which form certain compounds may, under certain conditions, be present. (allindianpatents.com)
  • The invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine for the treatment of diseases, disorders associated with the modulation of calcium release-activated calcium (CRAC) channel. (patentsencyclopedia.com)
  • About half of the existing medicines have heterocyclic structures. (chemicalbook.com)
  • Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the. (patents.com)
  • The structures of the compounds 2a-e were confirmed by their UV, IR, 1 H NMR, 13 C NMR and mass spectral data and elemental analyses. (banglajol.info)
  • That's why it's so useful to know the structures of major heterocyclic compounds for molecular biologists, pharmacists, organic chemists and for general public interested in what the stuff is made from. (asmolgam.com)
  • 1. This app has a bit aggressive "watermelon" design and its goal is not only to teach millions of iOS users about heterocyclic structures but also test the simplest possible "letter quiz" model. (asmolgam.com)
  • IUPAC recommends the Hantzsch-Widman nomenclature for naming heterocyclic compounds. (wikipedia.org)
  • Naming heterocyclic compounds is complicated because of the existence of many common names in addition to the internationally agreed-upon systematic nomenclature . (britannica.com)
  • It covers nomenclature, conformational aspects, Heterocyclic Chemistry - MSU Chemistry Devising a systematic nomenclature system for heterocyclic compounds presented a formidable challenge, which has not been uniformly concluded. (plancul-belge.be)
  • This study includes the nomenclature, reactivity and synthesis of such compounds. (uniss.it)
  • 1951: Chargaff's rules are described, highlighting the role of heterocyclic compounds (purines and pyrimidines) in the genetic code. (wikipedia.org)
  • Over a period of a decade hundreds of compounds corresponding to several classes (thiosemicarbazone, metronidazole analogues, azoles, pyrimidines, hydrazones, and triazines) have been synthesized, screened, and evaluated for their antiamoebic activity. (springer.com)
  • It is the main resource of polycyclic compounds and homologous heterocyclic compounds containing oxygen, nitrogen and sulfur. (freethesaurus.com)
  • About one hundred and ninety volatile compounds were detected using GC-MS which includes aldehydes ketones esters alcohols hydrocarbons ethers nitrogen oxygen sulfur phenols free acids heterocyclic compounds and lactones. (freethesaurus.com)
  • We collected house dust and indoor air samples in 49 California homes and analyzed for 76 semivolatile organic compounds-phthalates, polybrominated diphenyl ethers, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and pesticides. (ctdbase.org)
  • Aromatic compounds, though having double bonds, are extremely stable and do not readily undergo the addition reactions characteristic of other unsaturated compounds. (britannica.com)
  • Rovis has demonstrated that triazolium salt ( 667080 ) in the presence of a base can act as an N-heterocyclic carbene organocatalyst 1 in highly enantioselective intramolecular Stetter reactions. (sigmaaldrich.com)
  • A concise account of the more important properties and chemical reactions of the basic heterocyclic systems of organic chemisrty. (antiqbook.com)
  • Organic compounds containing at least one heterocyclic ring, and with no ring comprising a steroid, saccharide or peptide moiety. (uspto.gov)
  • A facile and convenient synthesis of new heterocyclic compounds containing a sulfamoyl moiety suitable for use as antimicrobial agents was reported. (hindawi.com)
  • Certain polycyclic aromatic hydrocarbons and heterocyclic compounds / this publication is the outcome of the meeting of the IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man, Lyon, 5-11 December 1972. (who.int)
  • More particularly provided is a compound shown in formula (I), an isomer, a hydrate, a solvate, a pharmaceutically acceptable. (sumobrain.com)
  • Treatment of 3 with hydrazine hydrate in ethanol afforded amino imino compound 4. (scirp.org)
  • For example, heterocyclic structure exists in chlorophyll in plants, hemoglobin in animal blood, alkaloids and glycosides as the active ingredient in herbs, some antibiotics and vitamins, certain composition of amino acids in protein and bases in nucleotide. (chemicalbook.com)
  • Mahmood, Z., Ahmad, A. Synthesis of Some Heterocyclic Compounds Derived From 2-Amino Benzothiazole. (iraqjournals.com)
  • The N-(1,3-benzothiazol-2-yl)-2-chloro acetamide compound(1) was prepared from the reaction of the compound (2-amino benzothiazole) with chloroacetyl chloride. (iraqjournals.com)
  • Also from the reaction of (2-amino benzothiazole) with phthalic anhydride or malic anhydride attended compounds (8) and (9) ,respectively. (iraqjournals.com)
  • Recently, 4-thiazolidones and the related heterocyclic compounds have been demonstrated to be a perspective source of innovative anticancer agents (Havrylyuk et al. (freethesaurus.com)
  • Within the modified compounds 7 b (4-nitro-substituted pyrazole) turn to be more potent against all bacterial strains. (elsevier.com)
  • A great number of heterocyclic compounds were found to be excellent inhibitors of copper and steel corrosion. (lap-publishing.com)
  • Antimicrobial evaluation of some selected examples from the synthesized products was carried out whereby four compounds were found to have moderate activities and one compound showed the highest activity. (hindawi.com)
  • Demeunynck, M. Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds. (mdpi.com)
  • Furdui B, Parfene G, Ghinea IO, Dinica RM, Bahrim G, Demeunynck M. Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds. (mdpi.com)
  • 2014. "Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds. (mdpi.com)
  • 2 The Stetter reaction (conjugate addition of an aldehyde to an α,β-unsaturated compound) is a superb method for the construction of 1,4-dicarbonyl compounds bearing quaternary stereocenters ( Scheme 1 ). (sigmaaldrich.com)
  • And by reaction compound(8) or (9) with o-phenylene diamine attended compounds (10) and (11) ,respectively. (iraqjournals.com)
  • The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). (patents.com)