A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and "classical" Kaposi sarcoma.
The type species of ROSEOLOVIRUS isolated from patients with AIDS and other LYMPHOPROLIFERATIVE DISORDERS. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter NK cell activity. HHV-6; (HBLV) antibodies are elevated in patients with AIDS, Sjogren's syndrome, sarcoidosis, chronic fatigue syndrome, and certain malignancies. HHV-6 is the cause of EXANTHEMA SUBITUM and has been implicated in encephalitis.
The type species of RHADINOVIRUS, in the subfamily GAMMAHERPESVIRINAE, isolated from squirrel monkeys. It produces malignant lymphomas (LYMPHOMA, MALIGNANT) in inoculated marmosets or owl monkeys.
A species of VARICELLOVIRUS causing abortion and respiratory disease in horses.
A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE.
A species of VARICELLOVIRUS that causes INFECTIOUS BOVINE RHINOTRACHEITIS and other associated syndromes in CATTLE.
Virus diseases caused by the HERPESVIRIDAE.
A species in the genus ROSEOLOVIRUS, of the family HERPESVIRIDAE. It was isolated from activated, CD4-positive T-lymphocytes taken from the blood of a healthy human.
A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting cattle.
A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
A species of VARICELLOVIRUS virus that causes a disease in newborn puppies.
The type species of the genus MARDIVIRUS in the family HERPESVIRIDAE. It is the etiologic agent of MAREK DISEASE, infecting domestic fowl and wild birds.
A species of VARICELLOVIRUS that causes a fatal MENINGOENCEPHALITIS in calves.
A species of VARICELLOVIRUS and the chief cause of rhinopneumonitis in horses.
Infection with ROSEOLOVIRUS, the most common in humans being EXANTHEMA SUBITUM, a benign disease of infants and young children.
A species of SIMPLEXVIRUS that causes vesicular lesions of the mouth in monkeys. When the virus is transmitted to man it causes an acute encephalitis or encephalomyelitis, which is nearly always fatal.
Proteins found in any species of virus.
A subfamily of HERPESVIRIDAE characterized by a short replication cycle. The genera include: SIMPLEXVIRUS; VARICELLOVIRUS; MAREK'S DISEASE-LIKE VIRUSES; and ILTOVIRUS.
A species of VARICELLOVIRUS producing a respiratory infection (PSEUDORABIES) in swine, its natural host. It also produces an usually fatal ENCEPHALOMYELITIS in cattle, sheep, dogs, cats, foxes, and mink.
A subfamily of HERPESVIRIDAE characterized by variable reproductive cycles. The genera include: LYMPHOCRYPTOVIRUS and RHADINOVIRUS.
Deoxyribonucleic acid that makes up the genetic material of viruses.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE. Its species include those causing CHICKENPOX and HERPES ZOSTER in humans (HERPESVIRUS 3, HUMAN), as well as several animal viruses.
A species of VARICELLOVIRUS causing coital exanthema in horses.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
A subfamily of HERPESVIRIDAE characterized by a relatively long replication cycle. Genera include: CYTOMEGALOVIRUS; MUROMEGALOVIRUS; and ROSEOLOVIRUS.
Established cell cultures that have the potential to propagate indefinitely.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
A species in the genus MAREK'S DISEASE-LIKE VIRUSES, in the family HERPESVIRIDAE, infecting turkeys.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Substances elaborated by viruses that have antigenic activity.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
The functional hereditary units of VIRUSES.
A species in the family AOTIDAE, inhabiting the forested regions of Central and South America (from Panama to the Amazon). Vocalizations occur primarily at night when they are active, thus they are also known as Northern night monkeys.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
The type species of the genus ILTOVIRUS found on every continent and affecting mainly chickens and occasionally pheasants.
The type species of VARICELLOVIRUS causing CHICKENPOX (varicella) and HERPES ZOSTER (shingles) in humans.
An acute, short-lived, viral disease of infants and young children characterized by a high fever at onset that drops to normal after 3-4 days and the concomitant appearance of a macular or maculopapular rash that appears first on the trunk and then spreads to other areas. It is the sixth of the classical exanthematous diseases and is caused by HHV-6; (HERPESVIRUS 6, HUMAN). (From Dorland, 27th ed)
A species of the family HERPESVIRIDAE, whose genus is so far unassigned. It is probably the causative agent of ADENOMA or ADENOCARCINOMA in the kidneys of certain frogs.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye.
Diseases of domestic and wild horses of the species Equus caballus.
A herpesvirus infection of CATTLE characterized by INFLAMMATION and NECROSIS of the mucous membranes of the upper RESPIRATORY TRACT.
A novel member of the tumor-necrosis factor receptor family that can also mediate HERPES SIMPLEX VIRUS TYPE 1 entry into cells. It has specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 and the homotrimeric form of LYMPHOTOXIN-ALPHA. The receptor is abundantly expressed on T-LYMPHOCYTES and may play a role in regulating lymphocyte activation. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
A subfamily in the family CEBIDAE that consists of four genera: CALLITHRIX (marmosets), CALLIMICO (Goeldi's monkey), LEONTOPITHECUS (lion tamarins), and SAGUINUS (long-tusked tamarins). The members of this family inhabit the tropical forests of South and Central America.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A herpesvirus infection of cattle characterized by catarrhal inflammation of the upper respiratory and alimentary epithelia, keratoconjunctivitis, encephalitis and lymph node enlargement. Syn: bovine epitheliosis, snotsiekte.
A species of SIMPLEXVIRUS associated with genital infections (HERPES GENITALIS). It is transmitted by sexual intercourse and close personal contact.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
A family of the New World monkeys inhabiting the forests of South and Central America. There is a single genus and several species occurring in this family, including AOTUS TRIVIRGATUS (Northern night monkeys).
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)
A species in the genus MAREK'S DISEASE-LIKE VIRUSES, in the family HERPESVIRIDAE, infecting chickens.
Any of various ruminant mammals of the order Bovidae. They include numerous species in Africa and the American pronghorn.
A highly contagious herpesvirus infection affecting the central nervous system of swine, cattle, dogs, cats, rats, and other animals.
Common name for a number of different species of fish in the family Cyprinidae. This includes, among others, the common carp, crucian carp, grass carp, and silver carp.
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.
Large woodland game BIRDS in the subfamily Meleagridinae, family Phasianidae, order GALLIFORMES. Formerly they were considered a distinct family, Melegrididae.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
A genus in the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, associated with malignancy in birds.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
Ribonucleic acid that makes up the genetic material of viruses.
A genus in the subfamily CALLITRICHINAE consisting of 12 species and found in Panama as well as South America. Species seen most frequently in the literature are S. oedipus (cotton-top marmoset), S. nigricollis, and S. fusicollis.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.
The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
The interactions between a host and a pathogen, usually resulting in disease.
A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Process of growing viruses in live animals, plants, or cultured cells.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
An unassigned genus in the family HERPESVIRIDAE, comprising one species Ictalurid herpesvirus 1 (Channel Catfish Virus).
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
A general term for various neoplastic diseases of the lymphoid tissue.
A genus of the subfamily CALLITRICHINAE occurring in forests of Brazil and Bolivia and containing seventeen species.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).
Genes that show rapid and transient expression in the absence of de novo protein synthesis. The term was originally used exclusively for viral genes where immediate-early referred to transcription immediately following virus integration into the host cell. It is also used to describe cellular genes which are expressed immediately after resting cells are stimulated by extracellular signals such as growth factors and neurotransmitters.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Diseases of animals within the order PRIMATES. This term includes diseases of Haplorhini and Strepsirhini.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
A member of tumor necrosis factor superfamily found on activated LYMPHOCYTES and MONOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to LYMPHOTOXIN BETA RECEPTOR and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A genus of the family CEBIDAE consisting of four species: S. boliviensis, S. orstedii (red-backed squirrel monkey), S. sciureus (common squirrel monkey), and S. ustus. They inhabit tropical rain forests in Central and South America. S. sciureus is used extensively in research studies.
A family of hoofed MAMMALS consisting of HORSES, donkeys, and zebras. Members of this family are strict herbivores and can be classified as either browsers or grazers depending on how they feed.
Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
A family of North American freshwater CATFISHES. It consists of four genera (Ameiurus, Ictalurus, Noturus, Pylodictis,) comprising several species, two of which are eyeless.
Premature expulsion of the FETUS in animals.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Methods used by pathogenic organisms to evade a host's immune system.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Nucleotide sequences repeated on both the 5' and 3' ends of a sequence under consideration. For example, the hallmarks of a transposon are that it is flanked by inverted repeats on each end and the inverted repeats are flanked by direct repeats. The Delta element of Ty retrotransposons and LTRs (long terminal repeats) are examples of this concept.
The process by which a DNA molecule is duplicated.
A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The relationships of groups of organisms as reflected by their genetic makeup.
A genus of the family Bovidae having two species: B. bison and B. bonasus. This concept is differentiated from BUFFALOES, which refers to Bubalus arnee and Syncerus caffer.
Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.
Immune status consisting of non-production of HIV antibodies, as determined by various serological tests.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Viruses whose nucleic acid is DNA.
An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
A genus of tree shrews of the family TUPAIIDAE which consists of about 12 species. One of the most frequently encountered species is T. glis. Members of this genus inhabit rain forests and secondary growth areas in southeast Asia.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.
Cultivation of natural faunal resources of water. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
A genus of the family HYLOBATIDAE consisting of six species. The members of this genus inhabit rain forests in southeast Asia. They are arboreal and differ from other anthropoids in the great length of their arms and very slender bodies and limbs. Their major means of locomotion is by swinging from branch to branch by their arms. Hylobates means dweller in the trees. Some authors refer to Symphalangus and Nomascus as Hylobates. The six genera include: H. concolor (crested or black gibbon), H. hoolock (Hoolock gibbon), H. klossii (Kloss's gibbon; dwarf siamang), H. lar (common gibbon), H. pileatus (pileated gibbon), and H. syndactylus (siamang). H. lar is also known as H. agilis (lar gibbon), H. moloch (agile gibbon), and H. muelleri (silvery gibbon).
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Serologic tests in which a positive reaction manifested by visible CHEMICAL PRECIPITATION occurs when a soluble ANTIGEN reacts with its precipitins, i.e., ANTIBODIES that can form a precipitate.
An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
A species of the genus VESIVIRUS infecting cats. Transmission occurs via air and mechanical contact.
A benign tumor of fibrous or fully developed connective tissue.
Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence A/AGCTT at the slash. HindIII is from Haemophilus influenzae R(d). Numerous isoschizomers have been identified. EC 3.1.21.-.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A genus of the family HERPESVIRIDAE, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans and new world primates. The type species human herpesvirus 4 (HERPESVIRUS 4, HUMAN) is better known as the Epstein-Barr virus.
One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence G/GATCC at the slash. BamHI is from Bacillus amyloliquefaciens N. Numerous isoschizomers have been identified. EC 3.1.21.-.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
A cell line generated from human embryonic kidney cells that were transformed with human adenovirus type 5.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Antibodies produced by a single clone of cells.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

Amplification of the six major human herpesviruses from cerebrospinal fluid by a single PCR. (1/1300)

We used a novel type of primer system, a system that uses stair primers, in which the primer sequences are based on consensus sequences in the DNA polymerase gene of herpesvirus to detect herpesviruses by PCR. A single PCR in a single tube detected the six major herpesviruses that infect the central nervous system: herpes simplex virus type 1 (HSV-1), and type 2 (HSV-2), cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella-zoster virus (VZV), and human herpesvirus 6 (HHV-6). We used the technique to analyze 142 cerebrospinal fluid (CSF) samples that had been stored at -80 degrees C and compared the results with those obtained previously for the same samples by standard, targeted PCR. Four hundred one targeted PCR tests had been run with the 142 samples to detect HSV-1, HSV-2, CMV, and VZV; screening for EBV and HHV-6 was not prescribed when the samples were initially taken. Eighteen CSF samples tested positive by classic targeted PCR. The herpesvirus consensus PCR detected herpesviruses in 37 samples, including 3 samples with coinfections and 17 viral isolates which were not targeted. Two samples identified as infected by the targeted PCR tested negative by the consensus PCR, and eight samples that tested positive by the consensus PCR were negative by the targeted PCR. One hundred three samples scored negative by both the targeted and the consensus PCRs. This preliminary study demonstrates the value of testing for six different herpesviruses simultaneously by a sensitive and straightforward technique rather than screening only for those viruses that are causing infections as suggested by clinical signs.  (+info)

Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (2/1300)

A retrospective evaluation of 215 consecutive recipients of high-dose chemotherapy (HDC) and autologous stem cell rescue (ASCR) was conducted to ascertain the incidence, temporal course, and outcome of varicella zoster virus (VZV) infection. Herpes zoster was identified in 40 individuals at a median of 69 days following ASCR. Six of these cases occurred at a median of 33 days prior to ASCR but following the initiation of high doses of stem cell mobilization chemotherapy. Twenty-five percent of patients demonstrated cutaneous or systemic dissemination and 32.5% required medical intervention for post-herpetic neuralgia. All except two individuals received antiviral chemotherapy. One patient with active VZV infection died of multiorgan failure 39 days after ASCR. Multivariate analysis of risk factors disclosed the significance of prophylactic acyclovir use in Herpes simplex virus seropositive individuals in reducing the risk of VZV infection. Moreover, the use of busulfan, thiotepa and carboplatin as the conditioning chemotherapy regimen was associated with an increased risk of subsequent VZV infection. The incidence of VZV reactivation after HDC and ASCR is similar to that observed following bone marrow transplantation but has an earlier onset. This may be related to an earlier induction of immunosuppression by stem cell mobilization chemotherapy administered prior to ASCR. We demonstrated a marked reduction in the proliferative and synthetic capacities of peripheral blood mononuclear cells obtained prior to and following stem cell mobilizing chemotherapy. Moreover, greater than 80% of VZV infections occurred within 6 months following ASCR and late cases were seldom observed compared to allogeneic and autologous bone marrow transplantation. The role of antiviral chemoprophylaxis during the period of maximum immunocompromise needs to be studied further in the HDC-ASCR setting.  (+info)

Characterization of Varicella-Zoster virus glycoprotein K (open reading frame 5) and its role in virus growth. (3/1300)

Varicella-zoster virus (VZV) is an alphaherpesvirus that is the causative agent of chickenpox and herpes zoster. VZV open reading frame 5 (ORF5) encodes glycoprotein K (gK), which is conserved among alphaherpesviruses. While VZV gK has not been characterized, and its role in viral replication is unknown, homologs of VZV gK in herpes simplex virus type 1 (HSV-1) and pseudorabies virus (PRV) have been well studied. To identify the VZV ORF5 gene product, we raised a polyclonal antibody against a fusion protein of ORF5 codons 25 to 122 with glutathione S-transferase and used it to study the protein in infected cells. A 40,000-molecular-weight protein was detected in cell-free virus by Western blotting. In immunogold electron microscopic studies, VZV gK was in enveloped virions and was evenly distributed in the cytoplasm in infected cells. To determine the function of VZV gK in virus growth, a series of gK deletion mutants were constructed with VZV cosmid DNA derived from the Oka strain. Full and partial deletions in gK prevented viral replication when the gK mutant cosmids were transfected into melanoma cells. Insertion of the HSV-1 (KOS) gK gene into the endogenous VZV gK site did not compensate for the deletion of VZV gK. The replacement of VZV gK at a nonnative AvrII site in the VZV genome restored the phenotypic characteristics of intact recombinant Oka (rOka) virus. Moreover, gK complementing cells transfected with a full gK deletion mutant exhibited viral plaques indistinguishable from those of rOka. Our results are consistent with the studies of gK proteins of HSV-1 and PRV showing that gK is indispensable for viral replication.  (+info)

Laboratory diagnosis of common viral infections of the central nervous system by using a single multiplex PCR screening assay. (4/1300)

A multiplex PCR assay that detects the four commonest causes of viral meningitis and encephalitis in the United Kingdom (herpes simplex virus [HSV] type 1 [HSV-1], HSV type 2 [HSV-2], varicella-zoster virus [VZV], and enteroviruses) was developed, and its sensitivity was compared with those of similar assays described previously for this application. Compared to the previous assays, this single multiplex PCR assay had higher molecular sensitivities for the detection for each of the viruses and improved utility for routine use in a diagnostic laboratory. The assay was used to test a series of 1,683 consecutive cerebrospinal fluid (CSF) samples between June 1997 and March 1998 inclusively. Viral nucleic acid was detected in 138 (8.2%) of the CSF samples, including enteroviruses in 51 samples, HSV-2 in 33 samples, VZV in 28 samples, and HSV-1 in 25 samples. Compared to the accepted relative incidence of viral etiologies, aseptic meningitis due to HSV-2 infection was high, and in adult female patients with symptoms of aseptic meningitis, HSV-2 was the virus most commonly detected in the CSF.  (+info)

AIDS related eye disease in Burundi, Africa. (5/1300)

AIMS: To determine the prevalence of ocular manifestations in AIDS patients hospitalised in Bujumbura, Burundi, according to their CD4+ lymphocyte count, serological status for CMV and VZV, and general health status. METHODS: Prospective study of 154 consecutive patients who underwent general and ophthalmological examinations, including dilated fundus examination. AIDS was diagnosed on the basis of Bangui criteria and HIV-1 seropositivity. CD4+ lymphocyte counts were determined by the Capcellia method. CMV and VZV antibodies were detected with ELISA methods. RESULTS: The mean age was 37 (SD 9) years and 65% of the patients were male. Active tuberculosis was the most frequent underlying disease (61%). Almost all the patients (99%) were seropositive for CMV and VZV. Among the 115 patients for whom CD4+ lymphocyte counts were available, 86 (75%) had more than 100 cells x 10(6)/l. Ocular involvement comprised 16 cases of microangiopathy, six of opalescence of the anterior chamber, five of retinal perivasculitis, two of zoster ophthalmicus, two of viral retinitis, and one of opalescence of the vitreous. CONCLUSION: In Africa, the prevalence of ocular involvement in HIV infection is far lower than in Europe and the United States, possibly because most African patients die before ocular opportunistic infections occur.  (+info)

Transcript mapping and transregulatory behavior of varicella-zoster virus gene 21, a latency-associated gene. (6/1300)

Gene 21 is one of at least four genes transcribed during latent infection of varicella-zoster virus (VZV) in human ganglia. It may encode a nucleocapsid protein, but its function in lytic and latent infection is not clear. To characterize further the structure and the function of the gene 21 open reading frame (ORF 21), precise localization of its transcripts and their termini was determined by using Northern analysis, S1 nuclease or RNase protection, and primer extension assays. One abundant 3.5-kb transcript that spans ORF 21 was identified. A predominant transcription start site was defined at -78 nucleotide (nt) relative to the ORF 21 translation start codon ATG, and two potential TATA elements were identified at 26 and 83 nt upstream of the 5' end of gene 21 transcripts. Transcription was found to terminate 210 nt beyond the ORF 21 translation stop codon and immediately before the start codon of ORF 22. In transient expression assays, the ORF 21 showed no significant transregulatory activity on promoters of diverse kinetic classes. The ORF 21 promoter, however, was transactivated strongly by VZV infection or by ORF 62.  (+info)

Latent Varicella-zoster virus in human dorsal root ganglia. (7/1300)

To understand further the molecular events underlying the process of Varicella-zoster virus (VZV) latency in human ganglionic tissues, in situ hybridisation (ISH) for VZV RNA and DNA, and PCR in situ amplification for VZV DNA were used in human dorsal root ganglia from 12 individuals (3 normal and 9 who had died with AIDS). The results showed that (a) two separate regions of the VZV genome, represented by genes 4 and 40, were detected in neurons in two normal and three AIDS ganglia, (b) evidence of transcription of VZV genes 4, 21, 29, and 63 was found in normal and AIDS cases, and (c) VZV DNA and RNA for the same gene (gene 29) was detected in neurons in serial tissue sections in three cases. Thus more than one region of the VZV genome is present in neurons during VZV ganglionic latency, and the presence of both a VZV gene and its corresponding RNA transcript can be shown to occur in the same localised region of DRG tissue.  (+info)

Varicella-zoster virus-specific cellular immunity in subjects given acyclovir after household chickenpox exposure. (8/1300)

The time course of primary cell-mediated immune responses to varicella-zoster virus (VZV) among persons receiving acyclovir prophylaxis after exposure to chickenpox has not been well defined. Fifteen children who had household exposure to varicella received prophylactic acyclovir (40 mg/kg/day for 7-14 days after exposure) and were studied for development of both antibody and cell-mediated immunity (CMI) to VZV. Twelve developed antibodies and/or CMI; 10 had no symptoms and 2 manifested mild varicella. Two were already immune to varicella and had booster immune responses. One was not infected and subsequently developed full-blown varicella. Although acyclovir given after exposure to VZV is highly effective and does not appear to attenuate the immune response, it remains necessary to confirm whether, in the absence of clinical varicella, persons acquire specific immunity.  (+info)

Summary The major inverted repeat of 7319.5 base pairs is present at an internal site in the varicella-zoster virus genome and at one terminus. A DNA sequence of 7747 base pairs containing the repeat was determined and analysed. The G + C content of the repeat is not uniform, and is significantly higher than that of adjacent unique regions. The repeat contains a G + C-rich reiterated sequence, an A + T-rich sequence with the potential of forming a hairpin structure which may form part of an origin of DNA replication, and three open reading frames predicted to encode primary translation products with approximate molecular weights of 140 000, 30 000 and 20 000. The possibility is discussed that the expression of other open reading frames near the genome termini may depend upon genome conformation.
We describe three cases of patients with concomitant acute medullary or brainstem multiple sclerosis (MS) lesions and detectable spinal fluid varicella-zoster virus DNA. Herpes simplex virus PCR was also positive in two of the patients. One patient was re-punctured 2 weeks following the relapse, with negative results. The PCR findings greatly delayed correct diagnosis and treatment in all three patients. Based on our cases, we propose that inflammatory medullary and brainstem lesions could result in viral leakage, and possibly viral reactivation, from destroyed sensory neurons, yielding false-positive cerebrospinal fluid PCR results. As this can have diagnostic and therapeutic consequences, further studies are warranted to evaluate the clinical relevance of these findings.. Reference:. Torkildsen Ø, Power Ø, Storstein A. Detection of varicella-zoster virus DNA during medullary and brainstem relapses in multiple sclerosis. BMJ Case Rep. 2016 Feb 23;2016. ...
More than 500 hospital employees and 209 patients were exposed to varicella zoster virus (VZV) as a consequence of 22 uncontrolled hospital introductions that occurred over a period of 34 months. Five introductions of varicella were by hospital employees who acquired the infection outside the hospital. Successful infection control of VZV requires an accurate definition of the susceptible population and the limitation of transmission. Individuals with prior VZV infection are epidemiologically not at risk for developing clinical illness. Serologic screening of hospital employees with uncertain prior VZV history is effective in identifying those at risk of developing the infection. A prior history of intimate exposure to VZV does not imply immunity in the absence of clinical illness.. ...
Lab Reagents Human IgG antibody Laboratories manufactures the varicella zoster virus antibody immunity screen cost reagents distributed by Genprice. The Varicella Zoster Virus Antibody Immunity Screen Cost reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact virus Antibody. Other Varicella products are available in stock. Specificity: Varicella Category: Zoster Group: Virus Antibody. Virus Antibody information ...
Humoral and cellular immune responses to whole varicella-zoster virus (VZV) antigen and the VZV proteins glycoprotein I (gpI) and nonglycosylated protein p170 were evaluated in healthy children and adults given lyophilized live-attenuated varicella vaccine. Children received one dose of vaccine containing 950 pfu, whereas adults received two doses of 2500 pfu. After one year, the antibody titers of adult vaccinees to whole VZV and to gpI were significantly higher than those of children. Antibody titers to whole VZV, gpI, and p170 were lower among both vaccine populations than titers in naturally immune individuals, but vaccinees who seroconverted initially retained detectable VZV antibodies. Using T lymphocyte proliferation to measure cellular immunity, we found the mean (+/- SE) transformation index to whole VZV antigen to be 4.1 +/- 0.96 in children tested at one year, a mean significantly lower than the mean of 12.7 +/- 3.39 in adults and 13.0 +/- 1.67 in naturally immune subjects. These observations
Varicella zoster virus (VZV) is a highly neurotropic, exclusively human herpesvirus. Primary infection causes varicella (chickenpox), wherein VZV replicates in multiple organs, particularly the skin. Widespread infection in vivo is confirmed by the ability of VZV to kill tissue culture cells in vitro derived from any organ. After varicella, VZV becomes latent in ganglionic neurons along the entire neuraxis. During latency, virus DNA replication stops, transcription is restricted, and no progeny virions are produced, indicating a unique virus-cell (neuron) relationship. VZV reactivation produces zoster (shingles), often complicated by serious neurological and ocular disorders. The molecular trigger(s) for reactivation, and thus the identity of a potential target to prevent it, remains unknown due to an incomplete understanding of the VZV-neuron interaction. While no in vitro system has yet recapitulated the findings in latently infected ganglia, recent studies show that VZV infection of human neurons in
Varicella zoster virus Videos, Flashcards, High Yield Notes, & Practice Questions. Learn and reinforce your understanding of Varicella zoster virus.
Several vaccinia virus (VV)-varicella-zoster virus (VZV) recombinants expressing glycoprotein I (gpI) of VZV were isolated from the Prague strain of VV. One of these, v46, was inoculated intraperitoneally into mice. Groups of mice were bled 4 and 8 weeks later and their sera were examined for anti-VZV and anti-VV antibodies by ELISA. At 4 weeks, all mice inoculated with the three largest virus doses (107, 106 and 105 p.f.u.), and at 8 weeks all mice inoculated with the four highest virus doses (107, 106, 105 and 104 p.f.u.), had developed both anti-VV and anti-VZV antibodies. Antibodies were also detected in a high proportion of mice infected with lower doses of virus and in some instances VZV antibodies were present in the absence of VV antibodies. None of the animals inoculated in parallel with either a thymidine kinase-negative mutant of the original VV or diluent alone developed antibody reactive with VZV. The specificity of the reaction was assessed further by Western blotting using anti-gpI
Cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella-zoster virus (VZV) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection and are likely to impact the developing immune system. Little is known about the epidemiology of CMV and EBV infections in contemporary UK paediatric populations, particularly whether age at infection differs by ethnic group. Children enrolled in the Born in Bradford Allergy and Infection Study had a blood sample taken and a questionnaire completed at 12 and 24 months of age. Ordered logistic regression quantified associations between ethnicity and other risk factors and age at CMV/EBV/VZV infection (|12 months, 12-24 months, uninfected at 24 months). Pakistani children (n = 472) were more likely to be infected with CMV and EBV at a younger age than White British children (n = 391) (CMV: adjusted odds ratio (OR) 2.53, 95% confidence interval (CI) 1.47-4.33; EBV: adjusted OR 2.16, 95% CI 1.43-3.26). Conversely, Pakistani
This page includes the following topics and synonyms: Varicella Zoster Virus, Chickenpox, Chicken Pox, VZV, Human Herpesvirus 3, Varicella-Zoster Virus.
The varicella zoster virus (VZV) belongs to the Herpesviridaefamily that is responsible for varicella (chickenpox and shingles). Features of the varicella-zoster virus Like all viruses in the...
VZV gE is a multifunctional protein, involved in cell-cell fusion and cell-to-cell spread of viral particles and secondary envelopment of the cytoplasmic virions in the trans-Golgi network (9, 26, 27, 48). VZV gE has unique characteristics compared to gE in the other alphaherpesviruses. We have shown that, in contrast to these other viruses, VZV gE is required for VZV replication (25, 30) and that VZV gE has a nonconserved N-terminal region of the ectodomain that is essential for VZV replication (4). Importantly, specific VZV gE functional motifs are necessary for T-cell and skin tropisms involved in VZV pathogenesis (4, 31).. Given the importance of gE for VZV replication and pathogenesis, we investigated in detail the role of VZV transactivators and cellular transcriptional factors in the regulation of the VZV gE promoter in vitro and in vivo. We found that the major VZV transactivator, IE62 (38-40), is the viral regulatory protein with the most potent effect on the gE promoter compared to ...
Varicella-zoster virus (VZV) infection causes two clinically distinct forms of disease. Primary infection with VZV results in varicella (chickenpox), characterized by vesicular lesions in different stages of development on the face, trunk, and extrem
Varicella zoster virus (VZV) typically causes chickenpox upon primary infection. In rare cases, VZV can give rise to life-threatening disease in otherwise healthy people, but the immunological basis for this remains unexplained. We report 4 cases of acute severe VZV infection affecting the central nervous system or the lungs in unrelated, otherwise healthy children who are heterozygous for rare missense mutations in POLR3A (one patient), POLR3C (one patient), or both (two patients). POLR3A and POLR3C encode subunits of RNA polymerase III. Leukocytes from all 4 patients tested exhibited poor IFN induction in response to synthetic or VZV-derived DNA. Moreover, leukocytes from 3 of the patients displayed defective IFN production upon VZV infection and reduced control of VZV replication. These phenotypes were rescued by transduction with relevant WT alleles. This work demonstrates that monogenic or digenic POLR3A and POLR3C deficiencies confer increased susceptibility to severe VZV disease in ...
Varicella zoster virus (VZV) typically causes chickenpox upon primary infection. In rare cases, VZV can give rise to life-threatening disease in otherwise healthy people, but the immunological basis for this remains unexplained. We report 4 cases of acute severe VZV infection affecting the central nervous system or the lungs in unrelated, otherwise healthy children who are heterozygous for rare missense mutations in POLR3A (one patient), POLR3C (one patient), or both (two patients). POLR3A and POLR3C encode subunits of RNA polymerase III. Leukocytes from all 4 patients tested exhibited poor IFN induction in response to synthetic or VZV-derived DNA. Moreover, leukocytes from 3 of the patients displayed defective IFN production upon VZV infection and reduced control of VZV replication. These phenotypes were rescued by transduction with relevant WT alleles. This work demonstrates that monogenic or digenic POLR3A and POLR3C deficiencies confer increased susceptibility to severe VZV disease in ...
Varicella-zoster virus (VZV) is the etiological agent of chickenpox and shingles. Due to the viruss restricted host and cell type tropism and the lack of tools for VZV proteomics, it is one of the least-characterized human herpesviruses. We generated 251 monoclonal antibodies (MAbs) against 59 of the 71 (83%) currently known unique VZV proteins to characterize VZV protein expression in vitro and in situ. Using this new set of MAbs, 44 viral proteins were detected by Western blotting (WB) and indirect immunofluorescence (IF); 13 were detected by WB only, and 2 were detected by IF only. A large proportion of viral proteins was analyzed for the first time in the context of virus infection. Our study revealed the subcellular localization of 46 proteins, 14 of which were analyzed in detail by confocal microscopy. Seven viral proteins were analyzed in time course experiments and showed a cascade-like temporal gene expression pattern similar to those of other herpesviruses. Furthermore, selected MAbs ...
Varicella zoster virus (VZV) particle, coloured transmission electron micrograph (TEM). VZV is a member of the Herpes virus family and causes human chickenpox and shingles. Each particle (virion) consists of a deoxyribonucleic acid (DNA) core (red) surrounded by an icosahedral capsid (yellow), which is itself surrounded by an glycoprotein envelope (red ring). - Stock Image C002/3226
Press Release issued Jan 6, 2015: Infected with the varicella zoster virus (the virus that causes chickenpox and shingles)? The CBCD recommends taking Novirin or Gene-Eden-VIR. - Greg Bennett, CBCD
Objective:To study the correlation of clinical findings, histopathologic features, and detection of varicella-zoster virus (VZV) DNA in keratectomy specimens.Ma
Dissecting the mechanisms of this immunomodulation could provide important insights into varicella zoster virus pathogenesis and will be important when designing new vaccines and antivirals.|br /|  
1. ABSTRACT Varicella zoster virus (VZV) is the herpesvirus which causes the childhood disease varicella, also known as chickenpox, and the adult disease herpes zoster, also known as shingles. These distinct diseases are separated by a lengthy period of latency, often lasting decades, in which the virus resides within the ganglia of the host. VZV latency and reactivation from it have, for the most part, been extraordinarily difficult to examine. This is due to the lack of a good animal model for the VZV latent state, the inability to experimentally reactivate VZV under any circumstances and the caveats and problems encountered in examining human ganglionic tissue. However, insights into features of the molecular events of VZV latency have been gleaned from its pathogenesis and from recent advances in molecular probing of human and animal ganglia. Evidence suggests that the latent VZV genome may express transcripts unlike those of closely related herpesviruses, and some evidence suggests an ...
=pubmed_docsum Increased prevalence of varicella zoster virus DNA in cerebrospinal fluid from patients with multiple sclerosis. * Mancuso R, * Delbue S, * Borghi E, * Pagani E, * Calvo MG, * Caputo D, * Granieri E, * Ferrante P. ...
A case report of a a death in a 15-mo old girl who developed a varicella-like rash 20 d after varicella vaccination that lasted for 2 mo despite acyclovir treatment. The rash was confirmed to be due to vaccine-strain varicella-zoster virus.
Zerboni, L; Hinchliffe, S; Sommer, MH; Ito, H; Besser, J; Stamatis, S; Cheng, J; Distefano, D; Kraiouchkine, N; Shaw, A; +1 more... (2005) Analysis of varicella zoster virus attenuation by evaluation of chimeric parent Oka/vaccine Oka recombinant viruses in skin xenografts in the SCIDhu mouse model. Virology, 332 (1). pp. 337-46. ISSN 0042-6822 DOI: https://doi.org/10.1016/j.virol.2004.10.047 Full text not available from this repository ...
This test looks for antibodies in your blood that your body makes against the varicella-zoster virus. The virus causes chickenpox and shingles.
J Infect Dis. 2014 Mar 5. [Epub ahead of print] Focal encephalitis following varicella-zoster virus reactivation without rash in a healthy immunized...
Purpose : VZV keratitis is generally accepted to be an immune response rather than an active viral infection. Consequently, current treatment paradigms generally recommend steroids rather than antiviral agents. The purpose of this investigation is to determine the prevalence of positive polymerase chain reaction (PCR) in suspected cases and to identify predictive or associated factors. Methods : In this retrospective analysis, we identified 22 patients who presented to Geisinger Eye Institute with a clinical diagnosis of acute VZV keratitis and who underwent corneal swab and PCR for VZV. Univariate analysis of eyes positive (group 1) and negative (group 2) for VZV was performed to identify differentiating factors. Results : All participants had a history of VZV rash and all but one had pseudodendrites at the time of swab. Thirteen of 22 eyes (59.1%) had positive PCR for VZV. Mean time between rash and first ocular sign was 1.39 months (range -1 to 6.75) in group 1 and 10.63 months (range 0.1 to ...
With a total run time of just 50 minutes our Varicella-Zoster virus test kits will get you fast results. View product details and purchase online today.
With a total run time of just 50 minutes our Varicella-Zoster virus test kits will get you fast results. View product details and purchase online today.
Mouse mAb against varicella zoster virus (VZV) protein ORF19 (clone VZ 19N.01, #HR-VZV-10). Tested in ELISA; WB ISO 9001 certified.
Mouse mAb against varicella zoster virus (VZV) protein ORF16 (clone VZ 16.06, #HR-VZV-34). Tested in ELISA, IF, WB. ISO 9001 certified.
Diagnostic medical test Tzanck test for herpes and varicella-zoster viruses including diseases and symptoms diagnosed or ruled out by this test.
What is Famciclovir for? Famciclovir is an antiviral medication that is used for the treatment of symptoms of the herpes viruses including herpes simplex 1 and 2 as well as the varicella zoster virus. Herpes virus is responsible for cold sores and genital herpes while the varicella zoster virus is for chicken pox and shingles. […]. ...
Advances in Virology is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of virology.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Our analysis of IFN-α and IL-1α in VZV-infected and uninfected skin xenografts revealed a subtle interaction between VZV and epidermal cell cytokine responses. Type I interferons, IFN-α, and to a lesser extent, IFN-β, are the predominant mediators of innate antiviral activity. Constitutive IFN-α/β expression occurs in some cells or tissues, allowing an immediate antiviral response (13). IFN-α/β activation is induced by the Jak/Stat pathway when ligands bind to IFN-α/β receptors and stimulate transcription of the IFN regulatory factors (IRFs) (8). IRF3 and IRF7 are crucial for maximal expression of IFN-α/β (14, 15). Constitutive IFN-α/β signaling is thought to sustain IRF7 expression and enhance IFN-α/β production in a positive feedback loop in response to viral infection (16). Most viruses have mechanisms to inhibit synthesis of IFNs or evade downstream antiviral effects in order to allow viral spread before adaptive immunity develops. HSV, a human alphaherpesvirus closely ...
These are guidelines only and not intended to replace clinical judgment. Modification of therapy may be indicated based on patient comorbidities, previous antibiotic therapy or infection history. Doses provided are usual doses but may require modification based on patient age or comorbid conditions. Refer to Pediatric Antimicrobial Dosing Guideline for further guidance on dosing in children, and Neonatal Dosing Guideline for infants , 1 month of age. Consult a pediatric pharmacist for individualized renal or hepatic dose adjustment. For additional guidance, please contact Pediatric Infectious Diseases (ID) or the Pediatric Antimicrobial Stewardship Program (ASP).. ...
This webpage has been designed to provide readers a concise overview of some of the key characteristics associated with pathogens that are specifically known to cause human infection.
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This open-label, randomised, longitudinal crossover study includes healthy Kenyan VZV-seropositive women at low risk for HIV infection. Participants receive a single dose of a commercial live-attenuated VZVOka vaccine at either week 0 (n=22) or at week 12 (n=22) of the study and are followed for 48 and 36 weeks postvaccination, respectively. The primary outcome is the change on cervical CD4(+) T-cell immune activation measured by the coexpression of CD38 and HLA-DR 12 weeks postvaccination compared with the baseline (prevaccination). Secondary analyses include postvaccination changes in VZV-specific mucosal and systemic humoral and cellular immune responses, changes in cytokine and chemokine measures, study acceptability and feasibility of mucosal sampling and a longitudinal assessment of the bacterial community composition of the mucosa.. ETHICS AND DISSEMINATION ...
A recommendation for an expanded window for treatment with varicella-zoster immune globulin to prevent postexposure illness is now in harmony with advice from the American Academy of Pediatricians.
We demonstrate that under certain conditions this model can exhibit periodic behaviour as opposed to what is observed in VZV models that ignore the possibility of repeat varicella attacks. Periodicity can be induced by a combination of immune boosting and reinfection while the impact of zoster (shingles) recurrence on the onset of periodicity is negligible.. ...
Not only effectively lightens the skin, buy xenical pleasingly but also protects it from harmful UV rays and prevents pigmentation! Thank you for your feedback, perhaps levaquin cost it is very important for us? Die Tabletten Cialis Soft kann man mit einem Ausdruck „immer bereit, überall bereit bezeichnen. It probably isnt the best remedy for BP, Sorry not to be of any help. Frequent recurrences can be suppressed by taking a continuous daily dose of as little as 1 tablet daily? ранних симптомов губной лихорадки (те? Treatment of varicella-zoster virus infection in severely immunocompromised patients: a randomized comparison of acyclovir and vidarabine! Clinicians also should remain alert to the possibility of CMV-related corneal endotheliitis? Appellant cites no authority for why he should have been entitled to such an instruction? [4] Merișoarele (suc sau capsule) pot reduce incidența la cei cu infecții frecvente, [16] [17] dar toleranța pe termen lung ...
In the saliva samples, none tested positive for VZV DNA immediately following vaccination. However, during the first week of saliva testing post-inoculation, samples from 21 of the 36 participants tested positive for VZV DNA. On day 14, VZV was detected in samples from 11 participants, and at day 21, it was detected in 10 samples. By day 28, VZV remained present in just two of the study participants. VZV DNA was not detected in the saliva of 15 particpants throughout the 28-day experiment ...
Precipitin antigen was prepared from cultures infected with V-Z virus. Five separate antigens were identified. Reactions with radiolabeled antigen were detected by autoradiography. Partial purification of antigens could be accomplished in a discontinuous sucrose gradient, yet too little antigen was recovered from DEAE to make this a practicable purification method. Most of the antigenic activity was eluted from G-200 Sephadex. Antigens were identified by their degree of chemical stability. The α antigen was the only one which was stable at pH 3. The β antigen was destroyed by CsCl or DOC. DOC released the γ Δ, and ε antigens from the infectious viral particle.. ...
VZPG : Determination of immune status of individuals to the varicella-zoster virus (VZV)   Documentation of previous infection with VZV in an individual without a previous record of immunization to VZV
Herpes is a genus of viruses in the Herpesviridae family, the herpesviruses. This family includes the Herpes simplex virus, the cause of oral herpes (cold sores or fever blisters on the mouth or facial area) as well as genital herpes, the Epstein-Barr virus, the cause of mono, the Roseolovirus, the cause of roseola and the Varicella zoster virus, the cause of chicken pox and shingles.
Lab Reagents Human IgG antibody Laboratories manufactures the difference in varicella zoster pcr and varicella zoster ab reagents distributed by Genprice. The Difference In Varicella Zoster Pcr And Varicella Zoster Ab reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact Varicella PCR. Other Difference products are available in stock. Specificity: Difference Category: In Group: Varicella Zoster. Varicella Zoster information ...
Shingles is a viral infection which is medically recognized as herpes zoster. The natural remedies for shingles can effectively treat this viral infection. The varicella zoster virus is considered to be responsible for causing this disease. Additionally, this same virus causes chicken pox. The medicines for chicken pox do not eliminate the virus completely causing herpes zoster lately. Moreover, the herpes zoster disease is a short lived but irritating disease, and often occurs many years after the initial infection. The natural remedies for shingles can help a person to relieve this irritating disease. The herpes zoster virus becomes latent in the body without causing symptoms for many years. Moreover, this virus may remain in the non-neuronal satellite cells of dorsal root, autonomic ganglion or cranial nerve of the body, and causes herpes zoster lately. The natural remedies for shingles are very helpful in treating the herpes zoster virus by relieving the symptoms of the disease.. The very ...
To the Editor: I was quite pleased to see the article on varicella-zoster virus infections (1). Not only did this review provide a comprehensive synthesis of the current understanding of varicella-zoster immunology and molecular biology, but it also provided a much needed reminder that this virus is not as benign as we frequently think.. However, some of the epidemiologic statistics were either misinterpreted or else inadequately referenced. Specifically, the authors state that Adults with an underlying malignancy, who acquire varicella infection, may have a mortality rate as high as 50%. Because this rate seemed high, I consulted the article cited ...
Historically, varicella has been a disease predominantly affecting preschool and school-aged children in the United States. The live attenuated varicella vaccine was licensed in this country in 1995 and has been recommended for routine use in immunization of children 12 to 18 months of age. As an in …
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Varicella zoster virus (VZV) is a herpes virus that causes the chicken pox in children and shingles in adults. VZV first enters the body either through the respiratory tract or the eyes, and later infects the nervous system. Symptoms of fever and general discomfort are noticed between 10-21 days after initial exposure to the virus. A characteristic rash with red, spotted lesions will then appear in several stages, often spreading from the head downwards to the arms and legs. The rash will be more severe when seen in adults than in children.. Symptoms are most common in the winter and early spring. The disease may be spread through the air or by direct contact with infected individuals at any time until their rash has dried into crusted lesions. After symptoms clear, VZV remains inactive (latent) in nerves and results in lifetime immunity for most people. Reactivation later in life results in shingles (herpes zoster), which occurs in 50% of people by age 85. Shingles is most common in the elderly ...
Chickenpox (varicella zoster virus) lesions on a 2 year old girl. Shows two to four millimeter red papule which develops an irregular outline (rose petal). DSCN3668
Studies into the impact of vaccination against the varicella zoster virus (VZV) have increasingly focused on herpes zoster (HZ), which is believed to be increasing in vaccinated populations with decreasing infection pressure. This idea can be traced back to Hope-Simpsons hypothesis, in which a persons immune status determines the likelihood that he/she will develop HZ. Immunity decreases over time, and can be boosted by contact with a person experiencing varicella (exogenous boosting) or by a reactivation attempt of the virus (endogenous boosting). Here we use transmission models to estimate age-specific rates of reactivation and immune boosting, exogenous as well as endogenous, using zoster incidence data from the Netherlands (2002-2011, n=7026). The boosting and reactivation rates are estimated with splines, enabling these quantities to be optimally informed by the data. The analyses show that models with high levels of exogenous boosting and estimated or zero endogenous boosting, constant ...
The most striking finding of this study is the observation that VZV infection is associated with a 58-fold (95% CI: 40-85) increased risk of acquiring invasive GAS disease in children. It is not clear why chickenpox infection increases the risk for GAS infection so dramatically. One possibility is that invasive disease occurs as a consequence of the increased rate of superficial skin infection caused by the chickenpox lesions causing breakdown in the skin barrier. This is supported in part by the observation that the majority of chickenpox-associated infections occurring in this study had a soft tissue focus. However, the risk of invasive GAS infection at sites not directly related to skin was also increased, which suggests that other mechanisms predisposing to invasive infection are important. VZV infection itself may cause a predisposing immune aberration or may allow invasion via another less apparent portal, such as lesions on the oral mucosa or the respiratory tract. In favor of an immune ...
Varicella Zoster Virus gpI + gpIV antibody [SG1] for ELISA, ICC/IF, IP, WB. Anti-Varicella Zoster Virus gpI + gpIV mAb (GTX38719) is tested in Varicella Zoster Virus samples. 100% Ab-Assurance.
Simply put, Shingles is an attack on the bodys immune system. Shingles, also known as herpes zoster, is a viral infection that causes a painful skin rash which often include blisters. The blisters most commonly appear in a stripe like pattern, entering at the roots of nerves and follows them to the skin. Shingles is caused by a reactivation of the varicella zoster virus, also known as chicken pox. The chicken pox virus lies dormant for years, sometimes even decades, waiting to be reactivated. Approximately one in three Americans will experience Shingles in their lifetime. Typically, Shingles affect the elderly and the immunocompromised. As we age, our immune systems ability to fight off various illnesses naturally diminishes. Others who are fighting autoimmune disorders, being treated for cancer, or that have HIV are also at risk for developing the virus. Although rare, low risk healthy adults can develop shingles. Fortunately, they usually have an easier time recovering from the effects of ...
Shingles is a painful viral infection caused by the varicella zoster virus. This is the same virus that causes chicken pox. It isnt life threatening, but it does cause a painful rash. The shingles rash can appear anywhere on your body, but it usually appears as a band of blisters from the middle of your back around the side of the chest to the breastbone. Anyone who has had chicken pox can contract shingles. The virus lies inactive in nerve tissue near your spinal cord and brain. The virus may reactivate years later as shingles.. It is unknown why the virus is sometimes reactivated in the body. Experts believe that a weakened immune system could one explanation. As you grow older, your immune system becomes weaker. Shingles is more common in people over the age of 50. The risk also increases with age.. Shingles can also happen in younger people. This is more common when the immune system has been compromised by HIV/AIDS, cancer, cancer treatments, long use of steroids, or drugs that suppress ...
Varicella zoster virus DNA in mononuclear cells was studied by the polymerase chain reaction to obtain virological evidence of reactivation in the children who had contracted chickenpox in infancy. The results appear to explain why chickenpox in infancy is a risk factor for herpes zoster in immunocompetent children.. ...
Learn about the other conditions caused be herpes zoster, also called varicella zoster, that can be more dangerous than chicken pox or shingles.
Now heres a kicker. The shingles vaccine contains live, weakened [attenuated] varicella -zoster virus. It is 14 times as potent as the chicken pox vaccine. Putting this potency into a more aged body that may have less defenses doesnt make sense to me.. Ive heard of elderly people getting shingles after having the vaccine. It isnt fail safe and doesnt reduce the risk of lingering pain if shingles does erupt. Since all vaccines are suspect until theyve been monitored for decades for long term dangers, this new vaccine is only 50% effective.. It is not suggested for people with medical conditions suppressing their immune systems such as organ transplant patients. The vaccine is also the most expensive at 200.00. Merck is the manufacturer and has the ingredients listed as:. Live attenuated varicella-zoster virus. 31.16mg of sucrose [this is sugar]. 15.88mg of hydrolyzed porcine [animal protein usually gelatin pork]. 3.99mg of sodium chloride [salt]. 0.62mg of MSG [monosodium glutamate a meat ...
The virus lies dormant, lurking inside your body, and can become reactivated at any time. It sure sounds like something out of a science fiction movie, but the varicella zoster virus, which causes chickenpox and shingles, does just that. According to the Centers for Disease Control and Prevention, shingles affects about 1 million people in the United States each year. Once a person is infected with the varicella zoster virus, it remains in the nerve cell bodies even after the initial infection is past.. Unsightly shingles symptoms include a tender skin rash, usually on one side of the body. The initial rash forms blisters, which scab over in about a week. Additional symptoms may include chills, headache and fever.. Any area of the body can be affected, but the most common areas of occurrence are on the side of the body from the mid-back to the lower spine, says physician Bruce Ruben, MD, medical director of Encompass HealthCare in Michigan. Although it can occur at all ages, the incidence of ...
The term shingles refers to a condition caused by the varicella zoster virus, the same virus that causes chicken pox disease. After a person has had the chicken pox, the virus remains dormant, residing in nerve cells. Later on, as a result of many different factors, the virus may reactivate and leave the nerve cell and this is what causes herpes zoster, or shingles.. Reactivation usually occurs as a result of immune function abnormalities. Age, the presence of disease such as rheumatoid arthritis, or the use of immunosuppressive drugs all are risk factors.. Symptoms of shingles consist of an early prodrome or time before the storm. A patient will experience flu-like symptoms, headache, and possibly a low grade fever and chills.. Shortly thereafter, the patient will notice an itching, burning, uncomfortable sensation. This discomfort usually takes place on the chest or back, but it may also occur on the abdomen, head, face, neck, or an arm or leg.. Swelling of the lymph nodes near the area of ...
When a person becomes the victim of chicken pox, he gets rid of this disease within 10-15 days. Marks of chicken pox left behind the disease disappear after 5-6 months.
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We identified 13 studies involving 69,916 participants. The largest study included 38,546 participants. All studies were conducted in high-income countries and included only healthy Caucasian individuals ≥ 60 years of age without immunosuppressive comorbidities. Ten studies used live attenuated varicella zoster virus (VZV) vaccines. Three studies tested a new type of vaccine not yet available for clinical use. We judged five of the included studies to be at low risk of bias.. The incidence of herpes zoster, at up to three years of follow-up, was lower in participants who received the vaccine than in those who received a placebo: risk ratio (RR) 0.49; 95% confidence interval (CI) 0.43 to 0.56, risk difference (RD) 2%, number needed to treat to benefit (NNTB) 50; GRADE: moderate quality evidence. The vaccinated group had a higher incidence of mild to moderate intensity adverse events. These date came from one large study that included 38,546 people aged 60 years or older.. A study including 8122 ...
Good questions. The chickenpox virus was originally thought to be related to the much more dangerous smallpox virus, but in the early 1900s it was realized that it is not at all like smallpox. Chickenpox, or varicella, is a member of the herpesvirus family of virues. That means it is related to Epstein-Barr virus which causes mono, and herpesvirus which causes fever blisters and other things. As far as I can tell (Im looking at an introduction to the history of virology from 1978) the guys who first described the chickenpox virus were E. Paschen, 1919; EE Tyzzer, 1906; von Bokay 1909. In 1954 Weller discovered that chickenpox and shingles are caused by the same virus (sorry this isnt more useful). Chicken pox generally breakout in epidemic form. For instance, it is believed that 90% of susceptible people (people who havent had chicken pox before) will get it when they are exposed to the virus. It will often run through a school or daycare or house very rapidly. The good thing about chickenpox ...
January 12, 2018 /AccessWire/ - LAWRENCE, MA / ACCESSWIRE / January 12, 2018 / The goal of the Centers for Disease Control and Preventions immunization programs is to see a reduction in the appearance of a disease, but sometimes just the opposite occurs, states Frank Magliochetti, Parcae Capitals managing partner. With a B.S. in Pharmacy, Frank Magliochettis participation in Northeastern Universitys Masters of Toxicology Program provides the foundation for his expertise in pain management and disease control, which is why a 39% rise in Shingles over an 18-year period drew Mr. Magliochettis concern. Lingering dormant in the body following both infection and vaccination, the Varicella Zoster virus responsible for Chickenpox, can be reactivated, emerging as the Herpes Zoster Virus, or Shingles. To combat such re-emergent diseases, breakthrough pharmaceutical solutions are paramount.. Scientists and researchers have sought to discover why the Zoster virus is prone to make an appearance later ...
|strong|Mouse anti |em|Varicella zoster|/em| virus antibody, clone 5B7|/strong| recognizes |i|Varicella zoster |/i|virus (VZV) which is one of eight herpes viruses known to infect humans (and other ve…
Chicken pox is a virus that affects most of the children once in a life. Chicken pox is seen as a red-colored blister all over the body. It is considered as a childhood rite of passage. There are various symptoms of chicken pox but a rash is the most common symptom help to analyse this disease
What Does Chicken Pox Look Like | Day 1 To 12 What Does Chicken Pox Look Like Find out what does chicken pox look like, I had two over a weekend!
What Is Shingles? Shingles is a very painful disease caused by the same herpes virus that causes chicken pox (varicella zoster virus). Like other herpes ...
Infections are rare but important causes of stroke. Among these, varicella zoster virus has been known to cause ischemic stroke. During an attack of herpes zoster ophthal..
In northern China (Jilin, Liaoning, Beijing, Shanxi and Inner Mongolian provinces), all clinical samples from varicella patients since 2009 belonged to clade 2 [28, 31, 33]. However, three clade 1 or 3 VZV strains circulating before 2000 were identified in Beijing by Loparev [2]. We speculate that the three clade 1 or 3 strains, which were either imported or random cases, were not the predominate clades in light of the current studies. In western China, 120 VZV strains including four varicella and 116 zoster samples were described in Xinjiang. The results showed that four varicella strains belonged to clade 2 and 116 zoster strains were distributed into 3 clades: 75 in clade 2, 40 in clade 5, and one in clade 1 or 3. Geography might cause multiple clade strains to co-circulate because it borders Gansu province, where clade 2 strains predominate. Additionally, Southern Xinjiang borders Pakistan and India, where clade 5 strains have been circulating [34, 35]. Northern Xinjiang borders Russia, ...
TY - JOUR. T1 - Genetic variation in the HLA region is associated with susceptibility to herpes zoster. AU - Crosslin, D. R.. AU - Carrell, D. S.. AU - Burt, A.. AU - Kim, D. S.. AU - Underwood, J. G.. AU - Hanna, D. S.. AU - Comstock, B. A.. AU - Baldwin, E.. AU - De Andrade, M.. AU - Kullo, I. J.. AU - Tromp, G.. AU - Kuivaniemi, H.. AU - Borthwick, K. M.. AU - McCarty, C. A.. AU - Peissig, P. L.. AU - Doheny, K. F.. AU - Pugh, E.. AU - Kho, A.. AU - Pacheco, J.. AU - Hayes, M. G.. AU - Ritchie, M. D.. AU - Verma, S. S.. AU - Armstrong, G.. AU - Stallings, S.. AU - Denny, J. C.. AU - Carroll, R. J.. AU - Crawford, D. C.. AU - Crane, P. K.. AU - Mukherjee, S.. AU - Bottinger, E.. AU - Li, R.. AU - Keating, B.. AU - Mirel, D. B.. AU - Carlson, C. S.. AU - Harley, J. B.. AU - Larson, E. B.. AU - Jarvik, G. P.. PY - 2015/1/24. Y1 - 2015/1/24. N2 - Herpes zoster, commonly referred to as shingles, is caused by the varicella zoster virus (VZV). VZV initially manifests as chicken pox, most commonly in ...
Human varicella zoster-IgG ELISA kit is designed for analysing in-vitro quantitative concentrations of human IgG class antibodies against varicella zoster virus
We detected the presence of varicella zoster virus, as well as strong positivity for α-1 antitrypsin in the heart, kidneys, spleen, liver, skin, brain, lungs, pancreas, small and large intestines, and skeletal muscle. In regard to structural damage in the kidney and heart, we believe the observed damage is associated with the presence of autoantibodies to these organs, since both of them are rich in plakins and El Bagre-EPF patients present significant antibodies to plakin molecules.. ...
This study explored the neurologic vascular complications of varicella zoster virus (VZV). We describe four patients presenting at our institution with neurologic involvement by VZV. MR and MRA studies of the intracranial arterial circulation in the
Chicken Pox contagious viral disease. Causes itchy red rash turns to blisters Common childhood disease, epidemic is handiwork of Varicella Zoster Virus
Recently, the Judicial Panel on Multidistrict Litigation (JPML) created a new MDL for the federal lawsuits alleging injury caused by Zostavax, a live vaccine for the prevention of shingles. The lawsuits allege that the vaccine caused individuals to develop shingles or other injuries triggered from exposure to the live, attenuated varicella zoster virus contained in the vaccine,…. ...
An infectious diseases consultation should be sought for an immunocompromised patient who has VZV infection.. If you decide the patient has this disease, what therapies should you initiate immediately?. Chickenpox in the normal host is usually a benign infection and is treated at the discretion of both the family and physician. Chickenpox in the immunocompromised host should always be treated. Shingles should be treated regardless of the age of the patient.. 1. Anti-infective agents. If I am not sure what pathogen is causing the infection what anti-infective should I order?. Empiric therapy for the immune-competent adult without complications should be either valaciclovir or famciclovir. The oral suspension of aciclovir is used in children who are thought to require therapy. Table I summarizes treatment options. Of note, the second generation antiviral drugs, valaciclovir and famciclovir, are superior to aciclovir and have improved pharmacokinetics and pharmacodynamics. However, neither is ...
Varicella-Zoster disease (VZV) is a herpesvirus that becomes latent in sensory neurons after primary infection (chickenpox) and subsequently may reactivate to cause zoster. repression that is associated with latency of herpes simplex virus the prototypic alpha herpesvirus. Latency has been defined as the reversible nonproductive infection of a cell Amyloid b-peptide (25-35) (human) by a replication-competent virus (1). Several viruses have Amyloid b-peptide (25-35) (human) developed strategies to establish latency in the infected host to prevent their elimination by the host immune response. Varicella-Zoster virus (VZV) is an alpha herpesvirus that becomes latent in dorsal root ganglia (DRG) after primary infection and subsequently may reactivate to cause zoster. It is essential to understand the molecular mechanisms governing VZV latency and reactivation as approximately 15% of the human population will develop zoster (2 3 and possibly experience postherpetic neuralgia a debilitating pain ...
Herpes zoster (shingles) is caused by reactivation of the varicella-zoster virus that has been dormant since primary infection (i.e., chickenpox). It is characterised by pain in the area of the affected nerve, and crops of clustered vesicles (small fluid-filled spots) in the same area. Pain may occur days before the rash appears, or no rash may appear at all, which makes diagnosis difficult. Incidence is higher with age, and severity of symptoms is also much greater with age.. For more information on how acupuncture may be able to help with the symptoms of shingles, please download this factsheet. ...
Immediate Care centers, also known as urgent care facilities, provide an alternative to emergency room service that is useful in many cases. They help patients who need quick attention but arent suffering from a life-threatening injury or illness. For example, doctors commonly advise people who have developed a case of shingles to seek immediate care if they cannot get a quick appointment with their own primary care physician. Since shingles are so painful, people typically seek fast help even if they have not been instructed to.. Shingles can develop in individuals who have had chickenpox since the varicella-zoster virus never leaves the body. It only becomes dormant. The disorder causes a rash with inflammation and small blisters, and usually, significant pain. The rash develops on the skin along nerve lines since the condition actually is an infection of the nerves as well as of the skin.. A shingles vaccination is available, but it usually is only administered to people age 50 and older. ...
Shingles is an infection caused by the same virus that causes chickenpox (the varicella-zoster virus, which is a type of herpes virus).
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Sandhu on chicken pox stages: Chickenpox is highly infectious. Spread throughout households is very common with infection of up to 90% of vulnerable individuals who come into contact. Most infection occurs in those under 5 years of age and immunity increases with age until adulthood. http://patient.info/doctor/chickenpox-pro for topic: Chicken Pox Stages
Shingles, also known as herpes zoster, is a viral infection of a nerve and the skin supplied by the nerve. It is caused by the varicella-zoster (chicken pox) virus which lies dormant from childhood.. The symptoms of shingles include a blistering skin rash and pain. It occurs in the area of skin supplied by the infected nerve which is usually on the trunk may involve the eye and facial area. Pain (post herpetic neuralgia - PHN) may last for months or years even after the rash has healed and is very debilitating and affects quality of life.. Shingles occurs at any age, but the over 50s are considered at greatest risk . A vaccine against the varicella-zoster virus has become available in Ireland and is highly effective in preventing shingles and its associated complications.. In the UK there is a mass immunisation programme for the over 70s which is funded by the NHS which started in 2013. It is hoped that the HSE will provide a similar service in the coming years.. Whitemill Medical Centre is ...
The risk of varicella and herpes zoster in immunocompromised individuals necessitates the development of a safe and effective varicella-zoster virus (VZV) vaccine. live (< 0.005) vaccine, and that of perforin mRNA in the animals that received the inactivated vaccine i.d. (< 0.005). Importantly, raises in the manifestation of IFN- (= 0.025), granzyme B (= 0.004), and perforin (> 0.05) mRNAs were observed in the animals immunized i.d. with 1,995 PFU of inactivated vaccine relative to those immunized s.c. with the same dose. The proportion of animals expressing IFN- mRNA mirrored the proportion expressing IFN- protein (correlation coefficient of 0.88). VZV glycoprotein-specific and virus-neutralizing antibodies were produced with no significant intergroup variations. A booster i.d. administration of the 399-PFU dose of heat-inactivated vaccine enhanced the antibody reactions. These results demonstrate that i.d. administration of an inactivated VZV vaccine can be an efficient mode of immunization ...
Shingles is caused by the reactivation of varicella zoster virus in the spinal cord causing severe pain and rash. People usually develop chicken pox during
Question - What are the chances of getting chicken pox after vaccination?. Ask a Doctor about diagnosis, treatment and medication for Chicken pox, Ask an Internal Medicine Specialist
According to the CDC, only 1 of every 10 children experiences complications serious enough to see a pediatrician. Call a doctor if your childs fever lasts more than four days or peaks above 102 degrees F. Also, hot, red skin that seeps pus may be a sign of a bacterial infection. As mentioned, chicken pox has a mild effect on children; however, the disease can progress to pneumonia or encephalitis, both of which are serious - and potentially deadly. If your child is very sick - if he appears to be confused, has trouble walking, cant breathe or cant stop vomiting - this is cause for alarm. Contact your doctor immediately to discuss treatment options, if youre pregnant and havent had chicken pox or the vaccine for this disease.. ...
Are you worried that your baby has developed chicken pox symptoms? If the answer is yes, well, relax! Check out chicken pox in babies causes, symptoms & treatments
Chicken pox and pregnancy is a contagious viral infection that can be very serious. There are ways to protect you and your baby if you have chicken pox.
For many diseases, if you catch them once, you will never catch them again. Measles is a good example, as is chicken pox.When these diseases make it i
Online Doctor Chat - Infection of chicken pox during pregnancy, Ask a Doctor about diagnosis, treatment and medication for Chicken pox, Online doctor patient chat conversation by Dr. Raju A.T
Later, he studied the human pathogens, Helicobacter pylori and Plasmodium falciparum and their DNA replication and cell cycle ... Anindya Dutta, Suman Kumar Dhar (2001). "Geminin and ORC3N Inhibit Replication of Herpes Viruses, Pamiloma Viruses and Polyoma ... two pathogens affecting humans. An elected fellow of the National Academy of Sciences, India, Indian National Science Academy ... "Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin". Cell. 106 (3): 287-96. doi:10.1016 ...
... human herpesvirus 6 and human betaherpesvirus 7). It is also related to other herpesviruses within the Alphaherpesvirinae ... It is thus longer than all other human herpesviruses and one of the longest genomes of all human viruses in general. It has the ... Herpesviruses have some of the largest genomes among human viruses, often encoding hundreds of proteins. For instance, the ... Humans and monkeys serve as natural hosts. The eight species in this genus include the type species, human betaherpesvirus 5 ( ...
Davidson AJ (2007-08-16). "Comparative analysis of the genomes". Human Herpesviruses. Cambridge University Press. ISBN 978-0- ... also known by their taxonomical names Human alphaherpesvirus 1 and Human alphaherpesvirus 2, are two members of the human ... Play media Animal herpes viruses all share some common properties. The structure of herpes viruses consists of a relatively ... There exist commonly used vaccines to some herpesviruses, but only veterinary, such as HVT/LT (Turkey herpesvirus vector ...
There are nine known human herpesviruses. Of these, roseola has been linked to two: human herpesvirus 6 (HHV-6) and human ... It is caused by human herpesvirus 6 (HHV-6A, HHV-6B) or human herpesvirus 7 (HHV-7). Spread is usually through the saliva of ... "Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease ... Between the two types of human herpesvirus 6, HHV-6B has been detected much more frequently in hosts. HHV-6B has been shown to ...
Kaposi's sarcoma-associated herpesvirus and human T-lymphotropic virus. The most recently discovered human cancer virus is a ... Jordan MC, Jordan GW, Stevens JG, Miller G (June 1984). "Latent herpesviruses of humans". Annals of Internal Medicine. 100 (6 ... ISBN 978-0-7817-8215-9. Komaroff AL (December 2006). "Is human herpesvirus-6 a trigger for chronic fatigue syndrome?". Journal ... Infection by human T-lymphotropic virus can lead to tropical spastic paraparesis and adult T-cell leukaemia. Human ...
Jordan MC, Jordan GW, Stevens JG, Miller G (June 1984). "Latent herpesviruses of humans". Ann. Intern. Med. 100 (6): 866-80. ... For example, the human immunodeficiency virus (HIV) infects only human T cells, because its surface protein, gp120, can only ... Viral infections can cause disease in humans, animals and plants. In healthy humans and animals, infections are usually ... Alwine JC (2008). "Modulation of host cell stress responses by human cytomegalovirus". Human Cytomegalovirus. Curr. Top. ...
Human herpesvirus 8 (HHV8) is found in the lesions of all those who are affected. Risk factors include poor immune function, ... Ablashi DV, Chatlynne LG, Whitman JE, Cesarman E (July 2002). "Spectrum of Kaposi's sarcoma-associated herpesvirus, or human ... "Mucosal shedding of human herpesvirus 8 in men". The New England Journal of Medicine. 343 (19): 1369-77. doi:10.1056/ ... "Transmission of human herpesvirus 8 by blood transfusion". The New England Journal of Medicine. 355 (13): 1331-8. doi:10.1056/ ...
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press. ISBN 9780521827140. PMID 21348106 - ... One example is herpes virus family, Herpesviridae, all of which establish latent infection. Herpes virus include chicken-pox ... This is also seen with infections of the human papilloma virus in which persistent infection may lead to cervical cancer as a ... These viruses have incorporated into the human genome in the distant past, and are now transmitted through reproduction. ...
"The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro". ... Human Herpesvirus HHV-6A, HHV-6B AND HHV-7, L. Flamand, I. Lautenschlager, G.R.F. Krueger, D.V. Ablashi. Published by Elsevier ... Human Herpesvirus-6. G.R.F.Krueger and D.V. Ablashi (editors), 2006. Published by Elsevier Science Publishers, B.V.Amsterdam - ... Human Herpesvirus-6: Epidemiology, Molecular Biology, and Clinical Pathology, D.V. Ablashi, G.R.F. Krueger, and S.Z. Salahuddin ...
Similar observations have been made in the herpesvirus family; for example, Epstein-Barr virus encodes an interleukin protein ... with high sequence identity to the human interleukin-10, suggesting a recent evolutionary origin. McFadden, Grant (June 2000 ... 3 (1): 36-50. doi:10.1038/nri980. PMID 12511874. Lucas, A; McFadden, G (15 October 2004). "Secreted immunomodulatory viral ...
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nature Medicine. 1996;2(3):342-346. ... The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk ... Sexual Transmission and the Natural History of Human Herpesvirus 8 Infection. New England Journal of Medicine. 1998;338(14):948 ... "Researchers Find a Herpes Virus That Has a Role in an AIDS-Related Cancer". Howard Hughes Medical Institute. March 1, 1996. ...
"Psittacid Herpesviruses and Mucosal Papillomas of birds in Australia" (PDF). Wildlife Health Australia. 2017. Retrieved 24 May ... Although there is no exact route of transmission, Pacheco's disease is not transmissible by humans. It is also not ... However, due to the short and lack of severe clinical signs indicating a presence of the herpesvirus, the birds that experience ... This makes it essential for all recently imported psittacine birds to be tested for the presence of the herpesvirus before ...
pig skin has been shown to be the most similar to human skin. Pig skin is structurally similar to human epidermal thickness and ... Examples of viruses carried by pigs include porcine herpesvirus, rotavirus, parvovirus, and circovirus. Of particular concern ... Pigs are currently thought to be the best non-human candidates for organ donation to humans. The risk of cross-species disease ... physiological and anatomical similarities to human beings. For instance, human skin is very similar to pig skin, therefore pig ...
Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H (July 1999). "Overproduction of human Myt1 kinase induces a G2 cell cycle ... "Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency". The Journal of ... ISBN 978-0-87893-508-6. Booher RN, Holman PS, Fattaey A (August 1997). "Human Myt1 is a cell cycle-regulated kinase that ... Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (February 1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on ...
September 2018). Sandri-Goldin RM (ed.). "Human MxB Protein Is a Pan-herpesvirus Restriction Factor". Journal of Virology. 92 ( ... May 2018). "MxB is an interferon-induced restriction factor of human herpesviruses". Nature Communications. 9 (1): 1980. doi: ... October 2013). "Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection". Nature. 502 (7472): 559-62. doi: ... March 1988). "cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene". Somatic ...
The Kaposi sarcoma herpesvirus, KSHV, is a cancer virus that encodes four different IRF-like genes; including vIRF1, which is a ... Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ (December 1992). "Human interferon consensus sequence ... Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS (December 1994). "Identification of herpesvirus-like ... Moore PS, Boshoff C, Weiss RA, Chang Y (December 1996). "Molecular mimicry of human cytokine and cytokine response pathway ...
The presence of inherited, chromosomally integrated human herpesvirus 6 (HHV-6) DNA in the feto-placental unit is associated ... May 2020). "Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia". Nature ... The human placenta does not have a microbiome and placental bacterial infection is not a common cause of adverse pregnancy ... August 2019). "Human placenta has no microbiome but can contain potential pathogens". Nature. 572 (7769): 329-334. Bibcode: ...
Singh, V. K.; Lin, S. X.; Yang, V. C. (1998). "Serological Association of Measles Virus and Human Herpesvirus-6 with Brain ... 27 (3): 377-382. PMID 23606694. "AUTISM: PRESENT CHALLENGES, FUTURE NEEDS--WHY THE INCREASED RATES?". US Government Printing ... 13 (3): 252-259. doi:10.1080/13550280701278462. PMID 17613715. S2CID 35786437. Baird, G.; Pickles, A.; Simonoff, E.; Charman, T ... doi:10.1016/S0887-8994(97)00045-3. PMID 9308986. Singh, V. K. (1996). "Plasma increase of interleukin-12 and interferon-gamma. ...
Factors associated with human herpesvirus type 8 infection in an injecting drug user cohort. Sexually Transmitted Diseases. ... Medical Principles and Practice 115, 2009 Armenian HK, Khatib R. Developing an Instrument of Measuring Human Dignity and Its ... The Cambridge World History of Human Disease Edited by K.F. Kiple, Cambridge University Press, Cambridge England, 1993, 1176pp ... Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 16(5):400-406, 1997. Armenian HK, Pratt, LA, Gallo J, ...
"Human herpesvirus-6 entry into the central nervous system through the olfactory pathway". Proceedings of the National Academy ... 52 (3): 252-258. doi:10.1002/glia.20219. PMID 15920733. Barrilleaux, B.; Phinney, D. G.; Prockop, D. J. and O'Connor, K. C. ( ... 15 (1-2): 3-12. PMID 15623925.CS1 maint: multiple names: authors list (link) Norman, J. J.; Desai, T. A. (January 2006). " ... Bibcode:2006JNEng...3..172D. doi:10.1088/1741-2560/3/2/011. PMID 16705273. Niere, M.; Braun, B.; Gass, R.; Sturany, S. and ...
Human herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B that infect nearly all ... Human betaherpesvirus 7 Human betaherpesvirus 6A Human betaherpesvirus 6B Macacine betaherpesvirus 9 Murid betaherpesvirus 3 ... Like the other herpesviruses (Epstein-Barr virus, Human alphaherpesvirus 3, etc.), HHV-6 establishes lifelong latency and can ... Humans serve as natural hosts. There are currently three species in this genus including the type species Human betaherpesvirus ...
In the case of human herpesvirus-6, its entire genome is made over and over on a single strand. These long concatemers are ... Borenstein, Ronen; Frenkel, Niza (2009). "Cloning human herpes virus 6A genome into bacterial artificial chromosomes and study ... Arbuckle, Jesse (2011). "The molecular biology of human herpesvirus-6 latency and telomere integration". Microbes and Infection ... 77 (3): 355-61. doi:10.1016/0022-2836(73)90443-9. PMID 4580243. Oxford Dictionary of Biochemistry and Molecular Biology, 2nd ed ...
Allergy to human immunoglobulin is a contraindication. HIV has never been transmitted by HBIG. As with all blood-derived ... The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus. Bayhep B HepaGam B (US market; intravenous ... "HepaGam B- human hepatitis b virus immune globulin injection". DailyMed. 16 April 2020. Retrieved 14 July 2020. "Nabi-HB ( ... Hepatitis B immunoglobulin (HBIG) is a human immunoglobulin that is used to prevent the development of hepatitis B and is used ...
"Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200". Journal of Immunology. 175 (7): 4441-9. doi ... Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN (July 2004). "Human herpesvirus 8 K14 protein mimics CD200 in ... CD200R1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD200R1 genome location and ... Human HCRTR2 genome location and HCRTR2 gene details page in the UCSC Genome Browser. This article incorporates text from the ...
Except for human herpesvirus 8-positive diffuse large B-cell lymphoma, not otherwise specified, these lymphoid neoplasms are ... 6) Human herpesvirus 8-positive diffuse large B-cell lymphoma, not otherwise specified: This lymphoid neoplasm usually arises ... 4) Primary effusion lymphoma, human herpes virus-negative: Also termed primary effusion lymphoma, type II; it is characterized ... human herpes virus-positive: Also termed primary effusion lymphoma, type I; it is usually characterized by manifesting ...
Human herpesviruses have been treated as an exception (human rather than hominid). Following the host-derived term, species in ... The genus Herpesvirus was established in 1971 in the first report of the International Committee on Taxonomy of Viruses (ICTV ... All herpesviruses described since this system was adopted have been named in accordance with it. The recommended naming system ... A number of virus names (e.g. Epstein-Barr virus, also known as Human gammaherpesvirus 4) are so widely used that it may be ...
... human-to-human) or xenograft (animal-to-human), but it is helpful scientifically (for those searching or reading the scientific ... Examples of viruses carried by pigs include porcine herpesvirus, rotavirus, parvovirus, and circovirus. Porcine herpesviruses ... Human organs have been transplanted into animals as a powerful research technique for studying human biology without harming ... Since they are the closest relatives to humans, non-human primates were first considered as a potential organ source for ...
"Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus". Journal of ... Studies of non-human primates also show that social stress clogs arteries. Although humans cannot be randomized to receive ... In human research, the Trier Social Stress Task (TSST) is widely used to induce social stress in the laboratory. In the TSST, ... Humans are social beings by nature, as they typically have a fundamental need and desire to maintain positive social ...
Human herpesvirus 3 (HHV-3). Virus varicella-zoster adalah virus penyebab cacar air dan cacar ular (herper zoster).[1] Inang ... Clinical Microbiology Reviews 9 (3): 361-381. Diakses tanggal 13 Juni 2010. Cite uses deprecated parameter ,month=. (bantuan) ...
Genus Lymphocryptovirus (mit Species Human herpesvirus 4, en. Human gammaherpesvirus 4 (HHV-4), syn. Epstein-Barr-Virus (EBV)) ... Human metapneumovirus (HMPV), sowie Avianes Metapneumovirus - en. Avian metapneumovirus (AMPV). *Genus Orthopneumovirus, mit ... Genus Mastadenovirus (mit den Species Human mastadenovirus (Humane Adenoviren) A bis G) ... Human orthopneumovirus (HRSV), Bovines Respiratorisches Syncytialvirus - en. Bovine orthopneumovirus(BRSV), sowie Murines ...
U.S. Department of Health & Human Services.. *^ a b c Kaplan YC, Ozsarfati J, Etwel F, Nickel C, Nulman I, Koren G (November ... U.S. Department of Health and Human Services, Office of Public Health and Science, Office on Women's Health. July 2009. ... 3: CD011154. doi:10.1002/14651858.CD011154.pub2. PMC 7077870. PMID 32175593.. *^ a b c d Sagransky M, Yentzer BA, Feldman SR ( ... 978-3-642-64261-6. . ISSN 0171-2004.. *^ a b c d Kamangar F, Shinkai K (October 2012). "Acne in the adult female patient: a ...
... such as oral hygiene and human herpesviruses. This condition can develop into necrotizing ulcerative periodontitis. This is an ... Li, X; Lei, L; Tan, D; Jiang, L; Zeng, X; Dan, H; Liao, G; Chen, Q (May 2013). "Oropharyngeal Candida colonization in human ... The global human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) pandemic has been an important factor in ... About 35-50% of humans possess C. albicans as part of their normal oral microbiota. With more sensitive detection techniques, ...
Shiratori I., Yamaguchi M., Suzukawa M. et al. Down-regulation of basophil function by human CD200 and human herpesvirus-8 ... Douglas J., Albertson D.G., Barclay A.N. et al. RFLP and mapping of human MOX-1 gene on chromosome 3 (англ.) // Nucleic Acids ... Strausberg R.L., Feingold E.A., Grouse L.H. et al. Generation and initial analysis of more than 15,000 full-length human and ... McCaughan G.W., Clark M.J., Barclay A.N. Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein (англ ...
Herpesvirus: Cytomegalovirus,[17] Epstein Barr virus,[18] Varicella zoster virus, Human herpesvirus 6, Human herpesvirus 7 ve ... Arcay L (May 2001). "[Human microsporidiosis]". Invest Clin (Spanish; Castilian). 42 (Suppl 1), s. 3-42. PMID 11416983.. KB1 ... Atías A (June 1995). "[Update on microsporidiosis in humans]". Rev Med Chil (Spanish; Castilian). 123 (6), s. 762-72. PMID ... Pokora Z (2001). "[Role of gastropods in epidemiology of human parasitic diseases]". Wiad Parazytol (Polish). 47 (1), s. 3-24. ...
"Human herpesvirus-6 entry into the central nervous system through the olfactory pathway". Proceedings of the National Academy ... 52 (3): 252-8. doi:10.1002/glia.20219. PMID 15920733.. *^ a b c d Sandvig I, Hoang L, Sardella TC, Barnett SC, Brekken C, Tvedt ... 3 (7): 805-808.. *^ a b Pessach I, Shimoni A, Nagler A (November 2012). "Apoptotic cells in allogeneic hematopoietic stem cell ... doi:10.1007/s00018-010-0280-3. PMID 20143249.. *^ Quinn B (21 October 2014). "Paralysed man Darek Fidyka walks again after ...
Herpes virus cause a dendritic ulcer, which can recur and relapse over the lifetime of an individual. ... Corneal ulcers are a common human eye disease. They are caused by trauma, particularly with vegetable matter, as well as ... It is a common condition in humans particularly in the tropics and the agrarian societies. In developing countries, children ... Viral corneal ulceration caused by herpes virus may respond to antivirals like topical acyclovir ointment instilled at least ...
IL-17 je visoko homologan sa IL-17 kodiranim sa otvoreno čitajućim okvirom T limfotropnog rhadinovirusa Herpesvirus saimiri.[1] ... "Human IL-17: a novel cytokine derived from T cells". J. Immunol. 155 (12): 5483-6. PMID 7499828 ... IL-1 • IL-2 • IL-3 • IL-4 • IL-5 • IL-6 • IL-7 • IL-8 • IL-9 • IL-10 • IL-11 • IL-12 (B) • IL-13 • IL-14 • IL-15 • IL-16 • IL- ... Chem. 278 (3): 1910-4. PMID 12417590. doi:10.1074/jbc.M207577200. *↑ Cho ML, Kang JW, Moon YM, Nam HJ, Jhun JY, Heo SB, Jin HT ...
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press. ISBN 978-0-521-82714-0. Handsfield HH ... Fatahzadeh M, Schwartz RA (2007). "Human herpes simplex virus infections: epidemiology, pathogenesis, symptomatology, diagnosis ... 23 (3): 235-9. PMID 10939038. Davidovici BB, Grotto I, Balicer RD, Robinson NJ, Cohen D (November 2006). "Decline in the ... 80 (3): 185-91. doi:10.1136/sti.2003.005850. PMC 1744847 . PMID 15170000. Xu F, Sternberg MR, Gottlieb SL, Berman SM, Markowitz ...
"Medical Dictionary - Dictionary of Medicine and Human Biology. Archived from the original on 2013-02-05. Retrieved 2013-01-24. ... 22 (1): 90-3. doi:10.3171/2014.9.SPINE14159. PMID 25343407.. *^ a b Malik, Ali Irqam; Nelson, Richard L; Tou, Samson; Malik, ... doi:10.1007/s10096-011-1281-3. PMID 21553298.. *^ a b United Kingdom National Health Service 'Abscess' Archived 2014-10-30 at ... Rarely parasites can cause abscesses and this is more common in the developing world.[3] Specific parasites known to do this ...
The human IL-15 gene comprises nine exons (1 - 8 and 4A) and eight introns, four of which (exons 5 through 8) code for the ... or after infection of monocytes herpes virus, Mycobacterium tuberculosis and Candida albicans (Figure 2).[14] ... IL-15 is 14-15 kDa glycoprotein encoded by the 34 kb region of chromosome 4q31 in humans, and at the central region of ... In humans with history of acute infectious mononucleosis (the syndrome associated with primary Epstein-Barr virus infection), ...
Four orthopoxviruses cause infection in humans: variola, vaccinia, cowpox, and monkeypox. Variola virus infects only humans in ... If the mutation rate is assumed to be similar to that of the herpesviruses, the divergence date of variola from Taterapox has ... 978-3-642-76200-0. .. *^ a b c d e f g h Fenner, F. (1988). "The History of Smallpox and its Spread Around the World" (PDF). ... Hays, J.N. (2005). Epidemics and Pandemics: Their Impacts on Human History. ABC-CLIO. pp. 151-52. ISBN 978-1-85109-658-9. .. ...
This onshore time is important to the lifecycle, and can be disturbed when substantial human presence occurs.[14] The timing of ... including analysis of phocine herpesvirus.[20] In the San Francisco Bay, some harbor seals are fully or partially reddish in ... Harbor seals are sometimes reluctant to haul out in the presence of humans, so shoreline development and access must be ... The transmission of phocine herpesvirus-1 in rehabilitating and free-ranging Pacific harbor seals (Phoca vitulina) in ...
Several human activities have led to the emergence of zoonotic human pathogens, including viruses, bacteria, protozoa, and ... A typical example is the herpes virus, which tends to hide in nerves and become reactivated when specific circumstances arise. ... Many of the most common primary pathogens of humans only infect humans, however, many serious diseases are caused by organisms ... Krauss H, Weber A, Appel M (2003). Zoonoses: Infectious Diseases Transmissible from Animals to Humans (3rd ed.). Washington, D. ...
Cervical cancer, vulvar cancer & Genital warts (condyloma), Penile cancer, Anal cancer (Human papillomavirus (HPV)) ... Unlike herpesviruses, which can remain inactive in the body for months or years before reappearing, molluscum contagiosum does ... Wart (caused by the Human papillomavirus; also similar in appearance to molluscum) ... 132 (1): 1-3. doi:10.1542/peds.2013-0116. PMID 23796740.. *^ DailyMed. Aldara (imiquimod) Cream for Topical use (Prescribing ...
"Human Molecular Genetics. 20 (R1): R21-7. doi:10.1093/hmg/ddr137. PMC 3095054. PMID 21459775.. ... Other functions for RNAi in mammalian viruses also exist, such as miRNAs expressed by the herpes virus that may act as ... 55 (3): 334-58. doi:10.1007/s000180050296. PMID 10228554. S2CID 9448271.. *^ a b c d e f g Kupferschmidt, K. (2013). "A Lethal ... 45,000 miRNA target sites within human mRNA 3'UTRs are conserved above background levels, and ,60% of human protein-coding ...
... human papillomavirus infection, Epstein-Barr virus and human immunodeficiency virus (HIV).[2] These factors act, at least ... Kaposi's sarcoma herpesvirus (Kaposi's sarcoma and primary effusion lymphomas), hepatitis B and hepatitis C viruses ( ... 51 (3): 315-30. doi:10.1093/alcalc/agv110. PMID 26400678.. *^ a b c d e f World Cancer Report 2014. World Health Organization. ... Molecular Pathology: The Molecular Basis of Human Disease. Amsterdam: Elsevier Academic Press. p. 66. ISBN 978-0-12-374419-7.. ...
Aphthous-like ulceration also occurs in conditions involving systemic immuno-dysregulation, e.g. cyclic neutropenia and human ... herpetiform ulceration is not caused by herpes viruses. As with all types of aphthous stomatitis, it is not contagious. Unlike ... 978-1-4160-3435-3. .. *^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah Brocklehurst P, Tickle M, ... and HLA-DR2 are examples of human leukocyte antigen types associated with aphthous stomatitis.[2][5] However, these HLA types ...
Jeang, K. T. (1996) In: Human Retroviruses and AIDS: "A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences". Los ... Green M, Loewenstein PM (December 1988). "Autonomous functional domains of chemically synthesized human immunodeficiency virus ... "Direct interaction of human TFIID with the HIV-1 transactivator Tat". Nature. 367 (6460): 295-9. Bibcode:1994Natur.367..295K. ... III-3-III-18 *^ Kim JB, Sharp PA (April 2001). "Positive transcription elongation factor B phosphorylates hSPT5 and RNA ...
... human (Homo sapiens). miR-181 may have a regulatory role with tumor suppressors genes of the human chromosome 1. It has been ... Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR (April 2005). "Kaposi's sarcoma-associated herpesvirus expresses an ... In humans, this microRNA is involved in the mechanisms of immunity, and in many different cancers (see below) it was found to ... Human miR-181a1 and miR-181b1 are clustered together and located on the chromosome 1 (37.p5), miR-181a2 and miR-181b2 are ...
eds.). Human herpesviruses : biology, therapy, and immunoprophylaxis. Cambridge: Cambridge University Press. ISBN 978-0-521- ... Belshe, Robert B. (1984). Textbook of human virology (2nd ed.). Littleton MA: PSG. p. 829. ISBN 978-0-88416-458-6. .. ... Humans are the only known species that the disease affects naturally.[7] However, chickenpox has been caused in other animals, ... Weller TH (1997). "Varicella-herpes zoster virus". In Evans AS, Kaslow RA (eds.). Viral Infections of Humans: Epidemiology and ...
Human vaccines[edit]. Viral diseases[edit]. Virus. Diseases or conditions. Vaccine(s). Brands ... Talimogene laherparepvec (T-VEC), - Herpes virus engineered to produce immune-boosting molecule. Vaccine components[edit]. * ... "Human Vaccines. 7 (11): 1192-1197. doi:10.4161/hv.7.11.17017. PMC 3323497 . PMID 22048120.. ... "Human Vaccines. 7 (11): 1225-1233. doi:10.4161/hv.7.11.18203. PMC 3323498 . PMID 22205439.. ...
... human-to-human) or xenograft (animal-to-human), but it is helpful scientifically (for those searching or reading the scientific ... Examples of viruses carried by pigs include porcine herpesvirus, rotavirus, parvovirus, and circovirus. Porcine herpesviruses ... Human organs have been transplanted into animals as a powerful research technique for studying human biology without harming ... This technique has also been proposed as an alternative source of human organs for future transplantation into human patients.[ ...
Human herpesvirus 5/Herpesvirus 5 humano (HHV-5) Cercopithecine herpesvirus 5/Herpesvirus 5 cercopitecino (CeHV-5) ... Panine herpesvirus 2/Herpesvirus 2 panino (PoHV-2) Pongine herpesvirus 4/Herpesvirus 5 ponxino (PoHV-4) Aotine herpesvirus 1/ ... O Citomegalovirus humano (Human cytomegalovirus) ou HCMV, tamén chamado Herpesvirus 5 humano (Human herpesvirus 5) ou HHV-5.[2] ... Panine herpesvirus 2, PaHV-2) coma Herpesvirus 4 ponxino (Pongine herpesvirus 4, PoHV-4). O SCCMV denomínase Herpesvirus 5 ...
It is a vector for Avipoxvirus, Newcastle disease virus, Falconid herpesvirus 1 (and possibly other Herpesviridae), and some ... In many parts of its range, peregrines now also nest regularly on tall buildings or bridges; these human-made structures used ... 978-84-87334-15-3. .. *^ a b c d e f g h i j k l m n Snow, D.W. (1998). The Complete Birds of the Western Palaearctic on CD-ROM ... 3-13. ISBN 978-0-12-100130-8. .. *^ a b Cade, T.J.; Enderson, J.H.; Thelander, C.G.; White, C.M., eds. (1988). Peregrine Falcon ...
Humans can be infected by viruses from five of the eight genera in the subfamily Parvovirinae: i) Bocaparvovirus (e.g. human ... Dependoviruses require helper viruses (e.g. herpesviruses) to replicate. They are also perfect candidates as gene vectors. They ... human parv4 G1). As of 2014, there were no known human viruses in the remaining three recognized genera: vi) Amdoparvovirus (e. ... experiments showed that both human cells and HeLa cells have transferrin receptors but there is no evidence of humans ...
Rask-Andersen M, Olszewski PK, Levine AS, Schiöth HB (2009). «Molecular mechanisms underlying anorexia nervosa: Focus on human ... Cercopithecine herpesvirus 1) in clinical samples». Journal of Virological Methods. 109 (2): 245-51. PMID 12711069. doi:10.1016 ... 47 (Pt 3): 335. PMID 18208640. doi:10.1348/014466507X272475.. *^ Lopez C, Tchanturia K, Stahl D, Booth R, Holliday J, Treasure ... 141 (5): 702-3. PMID 6143508.. *^ Peñas-Lledó E, Vaz Leal FJ, Waller G (2002). «Excessive exercise in anorexia nervosa and ...
"American Journal of Human Genetics. 71 (5): 1060-1071. doi:10.1086/344289. ISSN 0002-9297. PMC 385085. PMID 12373647.. ... 16 (3): 250-2. PMID 9631744.. *^ a b c d e f Vasudevan AR, Ginzler EM (August 4, 2009). "Established and novel treatments for ... A study called BLISS-76 tested the drug belimumab, a fully human monoclonal anti-BAFF (or anti-BLyS) antibody.[85] BAFF ... Micrograph of a section of human skin prepared for direct immunofluorescence using an anti-IgG antibody. The skin is from a ...
... (KSHV) is the ninth known human herpesvirus; its formal name according to the ... Schulz, T. F. (2000). "Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): Epidemiology and pathogenesis". The ... "Human herpesvirus 8 - A novel human pathogen". Virology Journal. 2: 78. doi:10.1186/1743-422X-2-78. PMC 1243244. PMID 16138925. ... "Postnatal human herpesvirus 8 and human immunodeficiency virus type 1 infection in mothers and infants from Zambia". The ...
... Designation: DNA from VZV strain Ellen [ATCC ® VR-1367™] Application: It is appropriate ... Quantitative Genomic DNA from Human herpesvirus 3 (HHV-3) (ATCC® VR-1367DQ™) Add to ... infected with Human herpesvirus 3 (VZV) strain Ellen (ATCC VR-1367). Contact Technical Service if lot-specific concentration ...
... human herpesvirus-3 translation, English dictionary definition of human herpesvirus-3. n. Abbr. CMV Any of a group of ... herpesviruses that attack and enlarge epithelial cells. Such viruses also cause a disease of infants characterized by... ... Define human herpesvirus-3. human herpesvirus-3 synonyms, human herpesvirus-3 pronunciation, ... Human herpesvirus 8, human herpesvirus 7. cy·to·meg·a·lo·vi·rus. (sī′tə-mĕg′ə-lō-vī′rəs). n. Abbr. CMV. Any of a group of ...
Replication of Varicella-Zoster Virus in Human Skin Organ Culture Shannon L. Taylor, Jennifer F. Moffat ... Varicella-Zoster Virus Activates Inflammatory Cytokines in Human Monocytes and Macrophages via Toll-Like Receptor 2 Jennifer P ... Refining Estimates of the Quantity and Distribution of Latent Herpes Simplex Virus 1 and Varicella-Zoster Virus DNA in Human ... Varicella-Zoster Virus Gene Product Encoded by Open Reading Frame 35 in Viral Replication In Vitro and in Differentiated Human ...
Molecular characterization of Kaposis sarcoma-associated herpesvirus/human herpesvirus-8 strains from Russia. J Gen Virol. ... Cassar O, Afonso PV, Bassot S, Plancoulaine S, Duprez R, Capuano C, Novel human herpesvirus 8 subtype D strains in Vanuatu, ... Molecular epidemiology of Kaposis sarcoma-associated herpesvirus/human herpesvirus 8 strains from Russian patients with ... Age-dependent human herpesvirus 8 (HHV-8) seroprevalence rates for 745 persons in southern Siberia 25-98 years of age who lived ...
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2). ... Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) ... Human herpesvirus 2 (strain HG52) OX=10315 GN=UL11 PE=1 SV=3 MGLAFSGARPCCCRHNVITTDGGEVVSLTAHEFDVVDIESEEEGNFYVPPDVRVVTRAPG ... Homo sapiens (Human) [TaxID: 9606]. ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_taxonomy_section"> ...
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1). ... Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) ... Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1 ... Human herpesvirus 1 (strain 17) OX=10299 GN=UL11 PE=1 SV=3 MGLSFSGARPCCCRNNVLITDDGEVVSLTAHDFDVVDIESEEEGNFYVPPDMRGVTRAPG ...
Compared to other β-herpesviruses, HHV-6B exhibits high similarity in capsid structure but organizational differences in its ... belongs to the β-herpesvirus subfamily of the Herpesviridae. To understand capsid assembly and capsid-tegument interactions, ... Human herpesvirus 6B (HHV-6B) belongs to the β-herpesvirus subfamily of the Herpesviridae. To understand capsid assembly and ... First discovered in 1986 as a member of the β-herpesvirus subfamily of Herpesviridae1, human herpesvirus 6 (HHV-6) is now ...
Members of the human Herpesviridaefamily are candidates for representing the macroenvironmental factors associated with ... human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6), human herpesvirus 7 (HHV-7) and human herpesvirus 8 (HHV-8) was ... Association of human herpesvirus 6 and human herpesvirus 7 with demyelinating diseases of the nervous system. J Neurovirol 7: ... Huang LM, Lee CY, Lee PI, Chen JM, Wang PJ (1991) Meningitis caused by human herpesvirus-6. Arch Dis Child 66:1443-1444PubMed ...
Dewhurst, S (2004). "Human Herpesvirus Type 6 and Human Herpesvirus Type 7 Infections of the Central Nervous System". Herpes: ... Clark, DA (2002). "Human Herpesvirus 6 and Human Herpesvirus 7: Emerging Pathogens in Transplant Patients". International ... "Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and ... "Reactivation of human herpesvirus 6 by infection of human herpesvirus 7". Journal of Medical Virology. Wiley InterScience. 60 ( ...
Age- and sex-specific seroprevalence of human herpesvirus 8 in Jamaica [3] (multiple letters). / Manns, A.; Strickler, Howard; ... Age- and sex-specific seroprevalence of human herpesvirus 8 in Jamaica [3] (multiple letters). Journal of the National Cancer ... title = "Age- and sex-specific seroprevalence of human herpesvirus 8 in Jamaica [3] (multiple letters)", ... T1 - Age- and sex-specific seroprevalence of human herpesvirus 8 in Jamaica [3] (multiple letters) ...
Publications] 岡田 賢司: Human herpesvirus-6(HHV-6)感染症の臨床像-突発性発疹との関係- 小児科. 31(1). 105-111 (1990). *. Description. 「研究成果報告書概要(和文)」 ... Publications] 岡田賢司: Human herpesvirus-6(HHV-6)感染症の臨床像 小児科. 31. 105-111 (1990). *. Related Report. 1989 Annual Research Report ... Serological studies on mother-to-child transmission and virulence as an opportunistic pathogen of human herpesvirus-6 (HHV-6). ... Human
Human herpesvirus 6 stays in the body long after the initial infection. In situations that diminish the strength of a persons ... Initial human herpesvirus 6 infections were recognized years ago and named roseola, sixth disease or exantham subitum. Of the 2 ... The human herpesvirus 6, according to the Centers for Disease Control and Prevention, infects nearly 100 percent of Americans. ... Symptoms of Human Herpesvirus 6 by DIANE HELENTJARIS Last Updated: Aug 14, 2017. ...
Frequent detection of Kaposis sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency ... Presence of human herpesvirus 8 variants in the oral tissues of human immunodeficiency virus-infected persons.J. Infect. Dis. ... The seroepidemiology of human herpesvirus 8 (Kaposis sarcoma-associated herpesvirus): distribution of infection in KS risk ... The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high ...
Here we describe the ways that human herpesviruses interact and interfere with the cellular autophagy machinery in order to ... Here we describe the ways that human herpesviruses interact and interfere with the cellular autophagy machinery in order to ... Recent research on the human herpesvirus Epstein-Barr Virus (EBV) suggesting that localisation within the nucleus can shelter ... Recent research on the human herpesvirus Epstein-Barr Virus (EBV) suggesting that localisation within the nucleus can shelter ...
Use of Immunoglobulin G Antibody Avidity for Differentiation of Primary Human Herpesvirus 6 and 7 Infections. K. N. Ward, D. J ... Use of Immunoglobulin G Antibody Avidity for Differentiation of Primary Human Herpesvirus 6 and 7 Infections ... Use of Immunoglobulin G Antibody Avidity for Differentiation of Primary Human Herpesvirus 6 and 7 Infections ... Use of Immunoglobulin G Antibody Avidity for Differentiation of Primary Human Herpesvirus 6 and 7 Infections ...
The unique region of the human herpesvirus 6 genomes is essentially collinear with the UL segment of human cytomegalovirus ... Diverse tropism of human B-lymphotropic virus (human herpesvirus 6) LUSSO P. ... A case of human herpesvirus-6 lymphadenitis with infectious mononucleosis-like syndrome * * SUMIYOSHI Yoshiaki ... IgG antibodies to human herpesvirus-6 in children and adults both in primary Epstein-Barr virus and cytomegalovirus infections ...
Human herpesvirus 8 (HHV-8) is one of the few human viruses that primarily targets these APC for infection, altering their ... is one of the few human viruses that primarily targets these APC for infection, altering their cytokine profiles, manipulating ... 1996). Human herpesvirus-8/Kaposis sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J. Exp. ... Human herpesvirus 8 (HHV-8) is one of the few human viruses that primarily targets these APC for infection, altering their ...
Human herpesvirus-6 (HHV-6) is unique among human herpesviruses in its ability to integrate its genome in the telomeric region ... Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer. Annie Gravel, Isabelle Dubuc, Angela Brooks-Wilson, ... Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer. Annie Gravel, Isabelle Dubuc, Angela Brooks-Wilson, ... Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer. Annie Gravel, Isabelle Dubuc, Angela Brooks-Wilson, ...
Increased lymphoproliferative response to human herpesvirus type 6A variant in multiple sclerosis patients.. Soldan SS1, Leist ... Several reports have suggested an association of human herpesvirus 6 (HHV-6) and multiple sclerosis (MS) based on ...
Acute cerebellitis in primary human herpesvirus-6 infection.. Kato Z1, Kozawa R, Teramoto T, Hashimoto K, Shinoda S, Kondo N. ...
... varicella zoster virus and human herpesvirus 6 in patients with recurrent aphthous stomatitis. Download Prime PubMed App to ... HumanHerpesvirus 6, HumanHumansImmunoglobulin GImmunoglobulin MLichen Planus, OralMaleMiddle AgedMouth MucosaPrevalence ... Search for human herpesvirus 6, human cytomegalovirus and varicella zoster virus DNA in recurrent aphthous stomatitis tissue. ... TY - JOUR T1 - Detection of serum antibodies against cytomegalovirus, varicella zoster virus and human herpesvirus 6 in ...
Genomic DNA from Human herpesvirus 1 (HSV-1) Strain McIntyre [ATCC® VR-539™] (ATCC® VR-539D™) ATCC® Number: VR-539D™ Product ... Human herpesvirus 1 (ATCC® VR-1493™) ATCC® Number: VR-1493™ Classification: Herpesviridae, Simplexvirus ... Human herpesvirus 1 (ATCC® VR-1778™) ATCC® Number: VR-1778™ Classification: Herpesviridae, Simplexvirus ... Human herpesvirus 1 (ATCC® VR-1789™) ATCC® Number: VR-1789™ Classification: Herpesviridae, Simplexvirus ...
Daily News Thousands of Mutations Accumulate in the Human Brain Over a Lifetime Single-cell genome analyses reveal the amount ... Thousands of Mutations Accumulate in the Human Brain Over a Lifetime. By Ruth Williams , December 7, 2017 ... Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until ... In chapter 3, "The Sense of Sensibility," author Wendy Jones uses scenes from one of Jane Austens most celebrated novels to ...
Detection of Human Herpesvirus 6 DNA in Clinical Samples of Patients by Polymerase Chain Reaction Amplification ... AIDS CMV Human Viruses Humanpathogene Viren PCR RNA Viren Viruses diseases hepatitis retroviruses virology virus ... Human Immunodeficiency Virus Type 1 (HIV-1) Detection by Polymerase Chain Reaction in Children of Infected Mothers ... Detection of Human T-cell Leukemia Virus Type 1 Provirus: Semiquantitative, Nested, Double Polymerase Chain Reaction ...
2) discovered a novel human herpesvirus (human herpesvirus 8 [HHV8], or KS-associated herpesvirus [KSHV]) during systematic DNA ... Human herpesvirus 8 (HHV8, also known as Kaposis sarcoma [KS]-associated herpesvirus) has been implicated as an etiologic ... 1997) Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature. ... 1998) Transformation of primary human endothelial cells by Kaposis sarcoma-associated herpesvirus. Nature. 394:588-592, pmid: ...
These two viruses belong to ,i,γ,/i,-Herpesvirus subfamily and are associated with several human cancers. Besides the effects ... A particular attention has been given to Epstein-Barr and Kaposis sarcoma associated Herpesvirus, viruses studied for many ... 5. Kaposis Sarcoma-Associated Herpesvirus (KSHV). KSHV or Human Herpesvirus-8 (HHV-8) is the last human γ-Herpesvirus ... F. Liu and Z. H. Zhou, "Comparative virion structures of human herpesviruses," in Human Herpesviruses: Biology, Therapy, and ...
Human herpesvirus 8 (HHV-8), also called Kaposi sarcoma (KS)-associated herpesvirus (KSHV), is a gamma human herpesvirus most ... A Review of Human Herpesvirus 8, the Kaposis Sarcoma-Associated Herpesvirus, in the Pediatric Population. J Pediatric Infect ... Blood-borne and sexual transmission of human herpesvirus 8 in women with or at risk for human immunodeficiency virus infection ... Human herpesvirus 8-associated hemophagocytic lymphohistiocytosis in human immunodeficiency virus-infected patients. Clin ...
Human,Vaccine,for,Herpes,Virus,on,the,Anvil,medicine,medical news today,latest medical news,medical newsletters,current medical ... Human Vaccine for Herpes Virus on the Anvil. Researchers at the University of California San Diego (UCSD) Skaggs S... CMV a ... New standards for Human Research Safety. 6. Human wasting disease linked to a gene. 7. The Human Mad Cow Case. 8. Human Growth ... Human Antibody That Can Block SARS. 10. Human immunity system can battle HIV.. 11. Two New Human Papilloma virus (HPV) vaccines ...
Other opportunistic viruses, human cytomegalovirus and HHV-7, also infect or reactivate in persons at risk. Another disease ... herpesvirus of which two variant groups (A and B) are recognized, is very common, approaching 100% in seroprevalence. Primary ... Primary human herpesvirus 7 infection: a comparison of human herpesvirus 7 and human herpesvirus 6 infections in children. J ... Yalcin S, Karpuzoglu T, Suleymanlar G, Mutlu G, Mukai T, Yamamoto T, Human herpesvirus 6 and human herpesvirus 7 infections in ...
Human herpesvirus-6 is a lymphotropic virus which infectssusceptible individuals during the first year of life andusually ... Human herpesvirus-6 is a lymphotropic virus which infects susceptible individuals during the first year of life and usually ...
  • 180 "VΛ"-shaped CATCs are observed in HHV-6B, distinguishing from the 255 "Λ"-shaped dimeric CATCs observed in murine cytomegalovirus and the 310 "Δ"-shaped CATCs in human cytomegalovirus. (nature.com)
  • The presence of DNA of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6), human herpesvirus 7 (HHV-7) and human herpesvirus 8 (HHV-8) was searched by specific nested polymerase chain reaction. (springer.com)
  • In this study, sera from 22 patients with RAS, 24 patients with oral lichen planus (OLP) and 15 healthy controls were screened for IgG and IgM class antibodies to human cytomegalovirus (HCMV), varicella zoster virus (VZV) and human herpesvirus 6 (HHV-6). (unboundmedicine.com)
  • Researchers at the University of California, San Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences have patented a strategy for developing a human vaccine to prevent against Human Cytomegalovirus (hCMV) infection and disease. (bio-medicine.org)
  • Human herpesvirus 6 (HHV-6) belongs to the subfamily Betaherpesvirinae ( 30 ), which is represented by Human cytomegalovirus (HCMV). (asm.org)
  • CSF PCR was negative for herpes simplex virus (HSV), cytomegalovirus (CMV), varicella-zoster virus (HZV), enterovirus, and human herpesvirus 8. (ajnr.org)
  • More than 60 percent of the world's population is infected with a type of herpes virus called human cytomegalovirus. (medicalxpress.com)
  • Ghodratnama F, Riggio MP, Wray D. Search for human herpesvirus 6, human cytomegalovirus and varicella zoster virus DNA in recurrent aphthous stomatitis tissue. (springer.com)
  • they are most closely related to human herpesvirus 7 and then to human cytomegalovirus. (asm.org)
  • Other opportunistic viruses, human cytomegalovirus and HHV-7, also infect or reactivate in persons at risk. (cdc.gov)
  • The closest homology and similarity in genome organization is to HHV-7 and next to human cytomegalovirus (HCMV). (cdc.gov)
  • The human herpesvirus 6 (HHV-6) U69 gene product (pU69) is the presumed functional homolog of the human cytomegalovirus (HCMV) UL97-encoded kinase (pUL97), which converts ganciclovir to its monophosphate metabolite in HCMV-infected cells. (aspetjournals.org)
  • HHV-6 is a lymphotropic and neurotropic β-herpesvirus that is closely related to human cytomegalovirus (HCMV) and human herpesvirus 7. (aspetjournals.org)
  • Human herpes virus 5 (HHV5) is the official name of cytomegalovirus (CMV). (medbroadcast.com)
  • The open reading frame encodes a protein of 830 amino acids (93.2K) with the characteristics of a transmembrane glycoprotein and close similarity to the gp58/116 complex of human cytomegalovirus (HCMV). (microbiologyresearch.org)
  • Three human betaherpesviruses, human cytomegalovirus (HCMV), human herpesvirus-6 (HHV-6), and HHV-7, establish latency in mononuclear cells and can reactivate to cause visceral disease. (jci.org)
  • Consider the paper entitled "Human Cytomegalovirus Persistence" published February 13, 2012 in the journal, Cellular Microbiology (3). (prweb.com)
  • HHV-8 infection was determined by nested PCR that amplified a 737-bp fragment of the ORFK1 in peripheral blood buffy coats of 85 HHV-8-seropositive and 10 HHV-8-seronegative persons ( 3 ). (cdc.gov)
  • Bello-Morales R, Fedetz M, Alcina A, Tabares E, Lopez-Guerrero JA (2005) High susceptibility of a human oligodendroglial cell line to herpes simplex type 1 infection. (springer.com)
  • The clinical findings of 47 patients with exanthema subitum (ES) serologically confirmed human herpesvirus-6 (HHV-6) infection were analyzed. (nii.ac.jp)
  • Sudden high fever is a distinctive feature of human herpesvirus 6 infection, which is spread by contact with an infected person's saliva. (livestrong.com)
  • Human herpesvirus 6 stays in the body long after the initial infection. (livestrong.com)
  • Consultation with a health-care provider should be sought for concerns about reactivation symptoms in a person with a weak immune system or about children who appear to have severe symptoms from human herpesvirus 6 infection. (livestrong.com)
  • A recently identified gammaherpesvirus, human herpesvirus 8 (HHV8), may be the causative agent of Kaposi's sarcoma (KS), a tumor commonly associated with human immunodeficiency virus (HIV) infection ( 1 , 4 , 19 , 21 ). (asm.org)
  • Human herpesvirus 8 (HHV-8) is one of the few human viruses that primarily targets these APC for infection, altering their cytokine profiles, manipulating their surface expression of MHC molecules, and altering their ability to activate HHV-8-specific T cells. (frontiersin.org)
  • recapitulate human HHV-8 infection and development of KS or other cancers associated with this herpesvirus. (frontiersin.org)
  • Thus, although in vitro models are suspect to lacking certain in vivo characteristics, we will focus in this review on HHV-8 infection of human APC as being the most relevant to this human species-specific herpesvirus. (frontiersin.org)
  • Acute cerebellitis in primary human herpesvirus-6 infection. (nih.gov)
  • In recent years, epidemiological and experimental studies have strengthened the link between this lymphotropic herpesvirus and KS by showing that HHV8 infection precedes development of tumors, tracks tightly with KS risk, and targets spindle cells ( 3 )( 4 )( 5 ). (rupress.org)
  • Nine human herpesviruses are known so far, and each of them causes a variety of diseases in both primary infection and reactivation. (springer.com)
  • Seventeen additional cases of B virus infection in humans were described through 1973 (2)* and four cases, including the first known case of person-to-person transmission of the virus, occurred in Pensacola, Florida, in 1987 (5). (cdc.gov)
  • This extreme degree of morbidity and mortality has given the impression that B virus infection in humans nearly always results in severe or fatal disease. (cdc.gov)
  • The purpose of the working group was to supplement existing methods with specific guidelines intended to minimize transmission of B virus infection from macaque monkeys to humans. (cdc.gov)
  • As with herpes simplex virus I infection in humans, primary infection with B virus in macaques may result in gingivostomatitis with characteristic buccal mucosal lesions, but it probably occurs frequently without such signs. (cdc.gov)
  • Except for one instance of person-to-person transmission, however, all cases of B virus infection in humans have occurred in persons exposed to monkeys or monkey tissues. (cdc.gov)
  • Persons who have handled macaques since B virus infection was first reported in humans number in the thousands, yet only 22 well-documented cases of infection have been described. (cdc.gov)
  • Human Herpes Virus 6 (HHV-6) is a virus which especially causes infection in CD4 + T lymphocytes and ranks among the herpes group that is widely seen all over the world. (omicsonline.org)
  • Maja Arnež, Tatjana Avšič-Županc, Tina Uršič, and Miroslav Petrovec, "Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia," Case Reports in Pediatrics , vol. 2016, Article ID 2483183, 3 pages, 2016. (hindawi.com)
  • A frequent etiology seen in this context is human herpesvirus-6 (HHV6) infection. (ajnr.org)
  • 1 , 2 Although rare cases of acute CNS infection have been reported in immunocompetent adults 3 - 6 and HHV6 has been proposed as a factor in the development of multiple sclerosis, 1 latent HHV6 causes no ill effects in most healthy adults. (ajnr.org)
  • Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease. (medicalxpress.com)
  • Infection with T. gondii in humans can occur in various ways. (merckmanuals.com)
  • Which of the following is the most common mode of infection in humans? (merckmanuals.com)
  • After initial infection, all herpesviruses remain latent within specific host cells and may subsequently reactivate. (merckmanuals.com)
  • In June 1989, two men were admitted to a Kalamazoo, Michigan, hospital with B virus (Herpesvirus simiae) infection. (cdc.gov)
  • A cluster of four cases in Florida in 1987 (2) prompted CDC to convene a working group to formulate new guidelines for the prevention of B virus infection in monkey handlers (3). (cdc.gov)
  • Such training must include the following: prevention of monkey-inflicted wounds, appropriate care of such wounds when they occur, signs and symptoms that might indicate human infection with B virus, and recognition of the severity of such infection. (cdc.gov)
  • B-virus infection in humans--Pensacola, Florida. (cdc.gov)
  • Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection. (bmj.com)
  • Because Kaposi sarcoma may be associated with human immunodeficiency virus (HIV) infection, researchers want to test the drug in people with and without HIV infection. (clinicaltrials.gov)
  • EBV persists for life in the human host while facing vigorous antiviral responses that are induced upon primary infection. (jimmunol.org)
  • Recently, the possible correlation between genital infection by human herpesviruses (HHVs) and male infertility has attracted considerable attention. (intechopen.com)
  • 3 , 9 Moreover, posttransplantation KS can resolve when immunosuppressive therapy is reduced, 9 and the introduction of effective antiretroviral therapy for HIV infection has led to a decline in KS incidence. (bloodjournal.org)
  • Human herpesvirus 6 DNA levels in cerebrospinal fluid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis. (semanticscholar.org)
  • Herpesvirus latency requires the virus to establish a persistent infection in cells without destruction by the immune system. (jci.org)
  • After the primary infection, the human alphaherpesvirinae sub-family remains quiescent in the nerve ganglia from which it can periodically reactivate, causing clinical manifestations. (intechopen.com)
  • To date a total of 8 human HVs are known, having the characteristic of establishing a life-long latent infection: a state from which the virus can be reactivated and result in recurring disease. (intechopen.com)
  • The chronic infection is poorly defined molecularly, but clinically manifests as low-level virus shedding over extended periods of time and often in the absence of symptoms (3). (prweb.com)
  • Infection with each herpesvirus produces distinctive clinical features and imaging abnormalities. (uptodate.com)
  • Initial human herpesvirus 6 infections were recognized years ago and named roseola, sixth disease or exantham subitum. (livestrong.com)
  • Indeed, the primary tropism of B cells by these gamma herpesviruses is uncommon among human virus infections. (frontiersin.org)
  • Improved diagnostic reagents and testing are currently needed for the serological detection of human herpesvirus 8 (HHV-8) infections. (asm.org)
  • Human papillomavirus (HPV) infections and their associations with oral disease. (springer.com)
  • Infections with human herpesvirus 6 (HHV-6), a ß-herpesvirus of which two variant groups (A and B) are recognized, is very common, approaching 100% in seroprevalence. (cdc.gov)
  • Even in the face of functional antiviral immune responses, herpesviruses are capable of establishing lifelong persistent infections in their hosts. (jimmunol.org)
  • Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis Emerging Microbes &Infections 6, e45 (June 2017). (medworm.com)
  • The virus is harmless to macaques or may cause only a herpetic rash in macaques, but in humans it often produces fatal infections of the brain and meninges. (tabers.com)
  • Herpes viral infections use the ancient genetic material found in the human genome to proliferate, mimicking the same process tumors have been found to manipulate, Mount Sinai researchers have shown for the first time. (neurosciencenews.com)
  • Herpesvirus infections of the nervous system. (uptodate.com)
  • Viral infections often cause disease in humans and animals, however they are usually eliminated by the immune system, conferring lifetime immunity to the host for that virus. (wikibooks.org)
  • Given that HHV-6B has a genome size of 162 kb-much smaller than that of HCMV-the question arises whether its β-herpesvirus-specific tegument protein, pU11, binds capsids in the same way as HCMV's homologous protein pp150/pUL32 does. (nature.com)
  • This indicates that the HHV-6 gB homologue is probably processed by proteolytic cleavage similar to its equivalents in HCMV and various other herpesviruses. (microbiologyresearch.org)
  • HCMV, EBV, KSHV) express viral proteins when the cells divide that tether the viral genome to chromosomes so that episomes are partitioned to daughter cells (ref. 3 and Figure 1B ). (jci.org)
  • HCMV is another herpesvirus that can establish latency, just like HSV and VZV. (prweb.com)
  • 2 ) discovered a novel human herpesvirus (human herpesvirus 8 [HHV8], or KS-associated herpesvirus [KSHV]) during systematic DNA screening of KS lesions. (rupress.org)
  • Human herpesvirus 8 (HHV-8), also called Kaposi sarcoma (KS)-associated herpesvirus (KSHV), is a gamma human herpesvirus most closely related to Epstein-Barr virus. (nih.gov)
  • In contrast to other herpesviruses which are not associated with malignancy, Epstein-Barr virus (EBV) and human herpesvirus type 8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus (KSHV), can cause certain cancers. (merckmanuals.com)
  • KS-Bcl-2, encoded by Kaposi's sarcoma-associated herpesvirus (KSHV), is a structural and functional homologue of the Bcl-2 family of apoptosis regulators. (pubmedcentralcanada.ca)
  • Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), also referred to as human herpesvirus 8 (HHV-8), is a gamma 2 herpesvirus implicated in several cancers, including KS, primary effusion lymphoma (PEL), and a subset of multicentric Castleman's disease. (pubmedcentralcanada.ca)
  • Among human viruses, KSHV is most closely related to the Epstein-Barr virus (EBV), a tumorigenic gamma 1 herpesvirus known to be associated with lymphomas and nasopharyngeal carcinoma ( 10 , 12 ). (pubmedcentralcanada.ca)
  • Kaposi sarcoma-associated herpesvirus (KSHV) is etiologically linked to Kaposi sarcoma (KS), a tumor genetically akin to lymphatic endothelial cells (LECs). (bloodjournal.org)
  • 4 KS-associated herpesvirus (KSHV) is linked to the etiopathogenesis of KS 5 , 6 and certain lymphoproliferations, including primary effusion lymphoma (PEL) 7 and a plasmablastic variant of multicentric Castleman disease (MCD). (bloodjournal.org)
  • Two human gammaherpesviruses, EBV and Kaposi's sarcoma-associated herpesvirus (KSHV), establish latency in B cells. (jci.org)
  • Human herpesvirus-6 (HHV-6) is unique among human herpesviruses in its ability to integrate its genome in the telomeric region of host chromosomes (reviewed in ref. 1 ). (aacrjournals.org)
  • Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death. (the-scientist.com)
  • Identified a decade ago as the causative agent of KS, human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus, has an approximately 165-kb genome encoding about 90 gene products ( 21 ). (asm.org)
  • In all of the patients with acute retinal necrosis (n=16) that were tested, either the HSV1 (n=2), HSV2 (n=3), or VZV (n=11) genome was detected. (bmj.com)
  • The CMV genome was detected in 3 patients with anterior uveitis of immunocompetent patients and in one immunocompromised CMV retinitis patient. (bmj.com)
  • 3. Uncoating occurs when there is either the separation of the capsid from the genome or rearrangement of the capsid proteins exposing the genome for transcription and replication. (issuu.com)
  • Human herpesviruses 6A and 6B (HHV-6A/B) are unique among human herpesviruses in their ability to integrate their genome into host chromosomes. (prolekare.cz)
  • Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. (prolekare.cz)
  • The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. (prolekare.cz)
  • The gene for the homologue of herpesvirus glycoprotein B (gB) has been identified in the genome of human herpesvirus 6 (HHV-6), strain U1102, and the nucleotide sequence was determined. (microbiologyresearch.org)
  • Human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi sarcoma. (cdc.gov)
  • Kaposi sarcoma (KS) is an opportunistic disease in human immunodeficiency virus (HIV) patients and the most common cancer associated with AIDS worldwide ( 12 ). (asm.org)
  • The herpesviruses are a family of double-stranded DNA viruses that infect a wide variety of organisms. (frontiersin.org)
  • J Infect Dis Ther 3:224. (omicsonline.org)
  • After herpesviruses infect a cell, their genomes are assembled into specialized protein structures called nucelosomes. (medicalxpress.com)
  • Many viruses and bacteria infect humans through mucosal surfaces, such as those in the lungs, gastrointestinal tract and reproductive tract. (medicalxpress.com)
  • Ranid herpesvirus 1, along with Ranid herpesvirus 2 and 3, are the only herpes viruses known to infect amphibians. (wikipedia.org)
  • List the herpes viruses that infect humans. (brainscape.com)
  • They infect a variety of animal hosts, including humans and cause complex clinical outcomes. (intechopen.com)
  • Because the virus does not infect animals, it is considered a safe vehicle for antigen display in humans and other species. (thefreedictionary.com)
  • Herpesviruses infect virtually all humans and establish lifelong latency and reactivate to infect other humans. (jci.org)
  • Eight herpesviruses infect humans ( Table 1 ). (jci.org)
  • With the exception of varicella-zoster virus (VZV), all human herpesviruses spread through saliva, mucosal or skin lesions, or genital secretions and infect oropharyngeal or genital tract mucosal epithelial cells or skin. (jci.org)
  • Three human alphaherpesviruses, herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) and VZV, establish latency in sensory neurons and reactivate from neurons to infect epithelial cells in the mucosa or skin, resulting in a vesicular rash. (jci.org)
  • However, the precise role of human herpesvirus 6 in these problems is still being determined as the interplay with other viruses complicate the picture. (livestrong.com)
  • Here we describe recent research on the human herpesviruses that has contributed to our understanding of, and interactions between, viruses, autophagy, and the immune system. (frontiersin.org)
  • A particular attention has been given to Epstein-Barr and Kaposi's sarcoma associated Herpesvirus, viruses studied for many years in our laboratory. (hindawi.com)
  • These two viruses belong to γ -Herpesvirus subfamily and are associated with several human cancers. (hindawi.com)
  • These genes which are also found in other herpes viruses such as chicken pox or herpes simplex have the same or very similar sequence, structure and function whether in human or mouse viruses, and present a novel target for the hosts T-cells to muster forces and attack the virus. (bio-medicine.org)
  • Herpesvirus simiae (B virus) is a member of the herpes group of viruses that is enzootic in rhesus (Macaca mulatta), cynomolgus (M. fascicularis) and other Asiatic monkeys of the genus Macaca. (cdc.gov)
  • Viruses which integrate into the cellular DNA (such as human immunodeficiency virus, HIV -1, or hepatitis B virus) are difficult to identify by molecular techniques, while viruses which exist in the clinical material in low concentrations are even more formidable to identify. (springer.com)
  • Volume 1 of Frontiers of Virology provides new information on the advan- tages of the use of the peR for the diagnosis of many human disease-causing viruses, as well as on some problems with its use. (springer.com)
  • Human herpesvirus 6 variant A (HHV-6A) and human herpesvirus 6 variant B (HHV-6B) are two closely related yet distinct viruses. (asm.org)
  • To measure the genomic DNA of human herpes viruses (HHV) in the ocular fluids and to analyze the clinical relevance of HHV in uveitis. (bmj.com)
  • An extensive, multi-cohort, multi-network analysis of what goes wrong in the Alzheimer's brain and why, has turned up none other than human herpes and other viruses. (alzforum.org)
  • Recombinant vaccinia viruses (rVVs), expressing high levels of pU69 from two HHV-6 strains (representing the A and B variant), were constructed and used to compare the ganciclovir-phosphorylating capacity of pU69 and pUL97 in human cells. (aspetjournals.org)
  • In 2012 these two variants were officially recognised as distinct species by the International Committee on Taxonomy of Viruses and named Human betaherpesvirus 6A and Human betaherpesvirus 6B. (wikipedia.org)
  • The herpes family of viruses includes 8 different viruses that affect human beings. (medbroadcast.com)
  • The viruses are known by numbers as human herpes virus 1 through 8 (HHV1 - HHV8). (medbroadcast.com)
  • Like other human herpes viruses, HHV6 and HHV7 are so common that most of humankind has been infected at some point, usually early in life. (medbroadcast.com)
  • It was found that the Human Immunodeficiency Viruses (HIV-1) are RNA viruses at the origin of Acquired Immune Deficiency Syndrome (AIDS). (benthamopen.com)
  • SIV became Human Immune Deficiency viruses (HIV-1). (benthamopen.com)
  • 3. Viruses do not have a system to produce ATP. (issuu.com)
  • Large viruses, such as the herpesviruses and poxviruses, can have higher-ordered and more complex structures. (encyclopedia.com)
  • Herpesviruses belong to a family of double‐stranded DNA (dsDNA) viruses commonly causing herpes in animals. (intechopen.com)
  • Human herpes viruses 6 and 7 have been implicated in the etiology of pityriasis rosea . (tripdatabase.com)
  • The acknowledgment that viruses are potent biological factors in driving many cancers have seen a dramatic upsurge in recent years in large part to the success of the human papilloma virus vaccine against invasive cervical carcinomas and followed by the awarding of the noble prize in medicine in 2008 to Dr. Harald zurHausen who identified the link between papilloma virus and cervical cancers. (indigo.ca)
  • Over the last few years there have been some volumes addressing different aspects of viruses and cancers and to some extent focusing on the DNA viruses, more specifically the human DNA viruses. (indigo.ca)
  • We will also cover other known oncogenic viruses associated cancers in other mammals in addition to humans. (indigo.ca)
  • The Varicella zoster virus (VZV) is one of the eight herpes viruses known to affect humans (and other vertebrates). (abcam.com)
  • The researchers found that herpes viruses appear to manipulate an ancient RNA species that originated several million years ago, called human satellite II RNA (HSATII RNA). (neurosciencenews.com)
  • It suggests that genetically engineered viruses may have a significant impact on the outcomes of angioplasty performed in humans. (bio-medicine.org)
  • Human trigeminal ganglia (nerve cell clusters) are known to frequently harbor both viruses, and there is evidence to suggest the presence of both VZV and HSV1 DNA in the same neuron (nerve cell). (prweb.com)
  • Herpes and Herpes Zoster sound similar because the viruses that cause both diseases are members of the same herpesvirus family. (prweb.com)
  • Human herpesvirus 6B (HHV-6B) belongs to the β-herpesvirus subfamily of the Herpesviridae . (nature.com)
  • First discovered in 1986 as a member of the β-herpesvirus subfamily of Herpesviridae 1 , human herpesvirus 6 (HHV-6) is now understood to be a set of two closely related herpesvirus species known as HHV-6A and HHV-6B. (nature.com)
  • it shows that pp150, a β-herpesvirus subfamily-specific tegument protein, forms a " △ "-shaped group-of-three structure on each of the 320 triplexes in a capsid, leading to a net that encloses the capsid. (nature.com)
  • Human betaherpesvirus 6A (HHV-6A) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family Herpesviridae, and order Herpesvirales. (wikipedia.org)
  • The report of a case of encephalitis caused by B virus in a monkey handler in 1932 indicated that B virus can be highly pathogenic for humans (1). (cdc.gov)
  • It is transmitted to humans by the mosquito or tick bite and is implicated in some cases of encephalitis. (tabers.com)
  • Clinical and imaging findings suggesting human herpesvirus 6 encephalitis. (semanticscholar.org)
  • Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging. (semanticscholar.org)
  • Human herpesvirus 6 encephalitis. (semanticscholar.org)
  • Human herpesvirus-6 (HHV6) is a ubiquitous neurotropic virus latent in most adults. (ajnr.org)
  • We recommend that individuals that wish to reduce the number of latent herpesviruses in their bodies take Gene-Eden-VIR or Novirin. (prweb.com)
  • Antibodies against HHV-8 latency-associated nuclear antigen were identified by immunofluorescent antibody assay by using the BC3 cell line ( 3 ). (cdc.gov)
  • 3 showed significant rises in the HHV-6 lgG antibody titers and 2 of the 5 patients with previous afebrile attacks also showed rises. (nii.ac.jp)
  • Several reports have suggested an association of human herpesvirus 6 (HHV-6) and multiple sclerosis (MS) based on immunohistochemical demonstration of HHV-6 antigens in inflammatory lesions, detection of increased HHV-6 specific serum antibody titers, and amplification of HHV-6 DNA from sera and cerebrospinal fluid of MS patients but not in controls. (nih.gov)
  • In 1992 the two variants were recognised within Human herpesvirus 6 on the basis of differing restriction endonuclease cleavages, monoclonal antibody reactions, and growth patterns. (wikipedia.org)
  • The frequent shedding of most herpesviruses in salivary or genital secretions indicates that despite neutralizing antibody and potent cellular immunity, most of the herpesviruses have evolved mechanisms to evade these immune responses. (jci.org)
  • To verify the possible role of human herpesviruses (HHVs) as triggering or aggravating factors in relapsing-remitting multiple sclerosis clinical outcome, we studied the prevalence of all eight human herpesviruses in whole blood samples collected from 51 MS patients and from 51 healthy controls. (springer.com)
  • The purpose of this study was to ascertain if the human herpesviruses (HHVs) or human papillomaviruses (HPVs) act as possible factors or co-factors in the pathogenesis of OLP. (springer.com)
  • HHVs are divided into three subfamilies (α‐, β‐ and γ‐herpesviruses) based on their unique properties ( Table 1 ) [ 2 ]. (intechopen.com)
  • HHVs are widespread among humans to the extent that more than 90% of adults are thought to be infected with at least one variety [ 2 ]. (intechopen.com)
  • There are eight human herpesviruses (HHVs). (uptodate.com)
  • Our results offer insights into HHV-6B capsid assembly and the roles of its tegument proteins, including not only the β-herpesvirus-specific pU11 and pU14, but also those conserved across all subfamilies of Herpesviridae . (nature.com)
  • Members of the human Herpesviridae family are candidates for representing the macroenvironmental factors associated with multiple sclerosis (MS) pathogenesis. (springer.com)
  • Human herpesvirus 7 (HHV-7) is one of nine known members of the Herpesviridae family that infects humans. (wikipedia.org)
  • Seven gene blocks in the central region (I-VII) designated as herpesvirus core genes are common to all Herpesviridae. (cdc.gov)
  • Is there an indication for serologic testing for human herpesvirus 8 (HHV-8) in asymptomatic HIV-infected children (compared with not testing) to guide clinical management? (nih.gov)
  • Researchers at UCSD hope to begin pre-clinical work on development of a human vaccine. (bio-medicine.org)
  • Since the discovery of each human herpesvirus, an abundance of findings related to them has accumulated in basic research and clinical medicine. (springer.com)
  • Despite the fact that the herpesviruses are genetically and structurally similar, they cause a wide array of generally non-overlapping clinical syndromes. (merckmanuals.com)
  • Despite now being recognised as paraphyletic, the name Human herpesvirus 6 still sees usage in clinical contexts. (wikipedia.org)
  • We sought to distinguish patients testing positive for human herpesvirus 6 from those testing negative, based on clinical features and magnetic resonance images. (semanticscholar.org)
  • Human herpes virus 6 plasma DNA positivity after hematopoietic stem cell transplantation in children: an important risk factor for clinical outcome. (semanticscholar.org)
  • Human herpesvirus 6 DNA in plasma after allogeneic stem cell transplantation: incidence and clinical significance. (semanticscholar.org)
  • This trend in CATC quantity correlates with the increasing genomes sizes of these β-herpesviruses. (nature.com)
  • HHV-6 infects nearly all human beings by the age of three and often results in fever, diarrhea, and the roseola rash. (nature.com)
  • Roseola infantum is a childhood disease caused by herpesvirus 6 (and sometimes 7). (merckmanuals.com)
  • Roseola is caused by two human herpesviruses , human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7), which are sometimes referred to collectively as Roseolovirus . (wikipedia.org)
  • Most children get Roseola between 6 months and 3 years of age. (stlouischildrens.org)
  • Roseola rash goes away in 2-3 days. (stlouischildrens.org)
  • Some children with Roseola just have 3 days of fever without a rash. (stlouischildrens.org)
  • B virus, Herpesvirus simiae: historical perspective. (cdc.gov)
  • The ability of autophagy to degrade proteins located within the nucleus, the site of herpesvirus latency and replication, is also considered. (frontiersin.org)
  • It is speculated that a varicella virus (HHV-3) immune defect could originate HSV- 1/HSV-2 recurrent herpes diseases that can be cured by varicella vaccine (2012). (benthamopen.com)
  • The Oka, anti-HHV-3, varicella vaccine is able to cure HSV1/HSV2 recurrent herpes diseases. (benthamopen.com)
  • One- child dose varicella vaccine could be proposed as the first step to overcome HHV-3 herpes deficiency in order to prevent AIDS pandemic. (benthamopen.com)
  • 3. Pneumonia in children can be caused by RSV, parainfluenza virus, adenovirus, and varicella-zoster virus (VZV). (issuu.com)
  • in humans, members of this family are responsible for chickenpox , oral and genital herpes , and mononucleosis . (everything2.com)
  • A dominant epitope within the human herpesvirus 8 (HHV8) ORF 65-encoded protein was mapped to an 8-amino-acid (aa) sequence (RKPPSGKK [aa 162 to 169]) by an amino acid replacement method. (asm.org)
  • In this study, we identified the dominant continuous epitope of the ORF 65-encoded protein and developed a peptide-based EIA for the detection of HHV8 antibodies in human sera. (asm.org)
  • Elongation of the autophagic membrane around a portion of cytoplasm involves the recruitment of more proteins and lipidation of the microtubule-associated protein light chain 3 (LC3) by the E2-like enzyme ATG3. (frontiersin.org)
  • Atg6, also named Beclin 1, represents a protein with a pivotal role in the autophagy induction [ 6 ] and the microtubule-associated protein light chain 3 (LC3), or Atg8, is a marker of the autophagic vacuoles [ 7 ]. (hindawi.com)
  • The human herpesvirus 6 (HHV-6) U51 gene defines a new family of betaherpesvirus-specific genes encoding multiple transmembrane glycoproteins with similarity to G protein-coupled receptors, in particular, human chemokine receptors. (jimmunol.org)
  • 3. Capsomer is the protein subunit that makes up the capsid. (issuu.com)
  • In general, these peptides result from protein degradation by cytosolic proteasomes and are then transported into the endoplasmic reticulum (ER) 3 lumen by the transporter associated with Ag processing, TAP. (jimmunol.org)
  • The success of the herpesviruses is largely due to their ability to establish latency and reactivate. (jci.org)
  • This hallmark is shared by all members of the herpesvirus family, classified into α-, β-, and γ-subfamilies. (jimmunol.org)
  • The human herpesvirus 6, according to the Centers for Disease Control and Prevention, infects nearly 100 percent of Americans. (livestrong.com)
  • Interestingly, integration of Marek disease virus (a chicken herpesvirus) into the telomeric region of chicken chromosomes is linked with the development of lymphomas ( 3 ). (aacrjournals.org)
  • HHV-6A has not been etiologically linked to any human disease, but such an association will probably be found soon. (asm.org)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • Its disease spectrum is not well defined, although it is thought by some to be more neurovirulent than Human betaherpesvirus 6B. (wikipedia.org)
  • Human Herpesvirus-6B Reactivation Is a Risk Factor for Grades II to IV Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. (prolekare.cz)
  • It is transmitted to humans by the bite of infected ticks and causes disease similar to that caused by Powassan virus. (thefreedictionary.com)
  • The causative agent was identified as a herpesvirus by electron microscopy and lack of cross-hybridization to a number of human herpesviruses (2) . (cdc.gov)
  • This event, known as cross-presentation, allows DCs to activate both CD4 + and CD8 + T cells, in response to an extracellular antigen [ 3 ]. (hindawi.com)
  • Human herpesvirus 8 (HHV8, also known as Kaposi's sarcoma [KS]-associated herpesvirus) has been implicated as an etiologic agent for KS, an angiogenic tumor composed of endothelial, inflammatory, and spindle cells. (rupress.org)
  • We conclude that vGPCR contributes to the development of the angioproliferative lesions observed in these mice and suggest that this chemokine receptor may play a role in the pathogenesis of KS in humans. (rupress.org)
  • Furthermore, a strategy of treatment and prevention has not yet been established for most human herpesviruses. (springer.com)
  • Ferrante P, Omodeo-Zorini E, Zuffolato MR, Mancuso R, Caldarelli-Stefano R, Puricelll S, Mediati M, Losciale I, Caput (1997) Human T-cell lymphotropic virus tax and Epstein-Barr virus DNA in peripheral blood of multiple sclerosis patients during acute attack. (springer.com)
  • Most babies become infected with the virus before their first birthday with essentially all infected by age 3. (livestrong.com)
  • What's new in human herpes-virus-6? (nii.ac.jp)
  • As with the other human gamma herpesvirus, Epstein Barr virus (EBV) ( Ning, 2011 ), HHV-8 targets APC both in vivo and in vitro . (frontiersin.org)
  • Human Vaccine for Herpes Virus on the Anvil ( Researchers at the University of Califo. (bio-medicine.org)
  • Human herpesvirus-6 is a lymphotropic virus which infects susceptible individuals during the first year of life and usually causes life-long latency. (prohealth.com)
  • Many of these gene products allow the virus to evade the human immune system ( 8 ). (asm.org)
  • Human herpes virus, commonly known as herpes simplex virus 1 and 2 (HSV-1 and HSV-2), is like that friend who ends up crashing on your couch and never leaves. (medicalxpress.com)
  • Initially designated HBLV, for human B-lymphotropic virus, HHV-6 was isolated fortuitously in 1986 from interleukin 2-stimulated peripheral blood mononuclear cells (PBMCs) of patients with AIDS or lymphoproliferative disorders (1) . (cdc.gov)
  • Ranid herpesvirus 1 (RaHV-1), also known as the Lucké tumor herpesvirus (LTHV), is a double-stranded DNA virus within the order Herpesvirales. (wikipedia.org)
  • Ranid herpesvirus 1 is a double-stranded DNA virus approximately 217kbp in size. (wikipedia.org)
  • This is due to the fact that it shares many of its genomic and pathogenic characteristics with Ictalurid herpesvirus 1, another virus within the family Alloherpesviridae. (wikipedia.org)
  • however, this virus is highly pathogenic in humans (1). (cdc.gov)
  • Human herpes virus 1 (HHV1) is also known as herpes simplex virus 1 (HSV1). (medbroadcast.com)
  • Human herpes virus 2 (HHV2) is also called herpes simplex virus 2 (HSV2). (medbroadcast.com)
  • Human herpes virus 6 (HHV6) is a recently observed agent found in the blood cells of a few patients with a variety of diseases. (medbroadcast.com)
  • Human herpes virus 7 (HHV7) is even more recently observed and is closely related to HHV6. (medbroadcast.com)
  • Human herpes virus 8 (HHV8) was recently discovered in the tumours called Kaposi's Sarcoma (KS). (medbroadcast.com)
  • Through their TCRs, CD8 + CTLs scrutinize body cells for the presence of intracellular foreign invaders reflected at the cell surface by virus-derived peptides bound to host MHC class I molecules (HLA in humans). (jimmunol.org)
  • The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration. (prolekare.cz)
  • Sixteen immunosuppresed patients were tested by polymerase chain reaction for human herpes virus 6 DNA in cerebrospinal fluid (nine positive results). (semanticscholar.org)
  • used to indicate that an individual has been infected with the human immunodeficiency virus but does not yet have AIDS. (thefreedictionary.com)
  • Alvarez-Lafuente R, De Las Heras V, Bartolome M, Garcia-Montojo M, Arroyo R (2006) Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study. (springer.com)
  • Alvarez-Lafuente R, de las Heras V, Garcia-Montojo M, Bartolome M, Arroyo R (2007) Human herpesvirus-6 and multiple sclerosis: relapsing-remitting versus secondary progressive. (springer.com)
  • Increased lymphoproliferative response to human herpesvirus type 6A variant in multiple sclerosis patients. (nih.gov)
  • Crystal Structures of HLA-B*1501 in Complex with Peptides from Human UbcH6 and Epstein-Barr Viru. (expasy.org)
  • On December 15, 2016 Human Herpesvirus 8 and Microsporidiosis were updated. (nih.gov)
  • 30(3):339-342, January 28, 2016. (lww.com)
  • 30(3):343-353, January 28, 2016. (lww.com)
  • 30(3):355-363, January 28, 2016. (lww.com)
  • 30(3):365-376, January 28, 2016. (lww.com)
  • 30(3):377-382, January 28, 2016. (lww.com)
  • 30(3):383-393, January 28, 2016. (lww.com)
  • Murine herpesvirus 68 in Tumorigenesis - Sam Speck 13. (indigo.ca)
  • In order to obtain basic data concerning the virulence of HHV-6 in the immunocompromised state, we evaluated whether or not reactivation or reinfection of HHV-6 occurs as other herpesviruses. (nii.ac.jp)
  • The presence of P4 antibodies in a panel of 61 human serum specimens was highly correlated with biopsy-confirmed Kaposi's sarcoma. (asm.org)
  • 1/22]: Genotypic characterization of Kaposi's sarcoma - associated herpesvirus in asymptomatic infected subj's and isolated populations a. (coursehero.com)
  • It is postulated that a primary HHV-3 immune weakness could be linked to herpes partnership with AIDS pandemic. (benthamopen.com)
  • Âlvarez-Lafuente R, Martín-Estefanía C, De las Heras V, Castrillo C, Cour I, Picazo JJ, Varelade Seijas E, Arroyo R (2002) Prevalence of herpesvirus DNA in MS patients and healthy blood donors. (springer.com)
  • Prevalence in 2 ethnic groups in Botswana = extremely high 3. (coursehero.com)
  • Cox M, Maitland N, Scully C. Human herpes simplex-1 and papillomavirus type 16 homologous DNA sequences in normal, potentially malignant and malignant oral mucosa. (springer.com)
  • A 2017 study looking at the human blood virome in 8,240 humans between the ages of 2 months to 102 years found that 20.37% of them were positive for HHV-7. (wikipedia.org)
  • Ranid herpesvirus 1 has not yet been isolated within cell lines, despite multiple efforts utilizing various cells from amphibian, mammalian, and piscine species. (wikipedia.org)
  • The past decade has provided ample evidence that herpesviruses have acquired gene products that thwart host antiviral responses ( 5 , 6 , 7 , 8 ). (jimmunol.org)
  • This persistence supports the idea that herpesviruses have acquired dedicated functions to avoid immune elimination. (jimmunol.org)
  • Herpesviruses have evolved elaborate mechanisms to modulate host immune responses. (bloodjournal.org)
  • 3 KS is a tumor of microvascular endothelium and gene-expression microarray (GEM) studies suggest that it belongs to the lymphatic endothelial lineage. (bloodjournal.org)
  • Di Luca D, Mirandola P, Ravaioli T, Bigoni B, Cassai E (1996) Distribution of HHV-6 variants in human tissues. (springer.com)
  • Two additional isolates of lymphotropic human herpesviruses, U1102 and Gambian, genetically similar to HBLV, were obtained 1 year later from PBMCs of African AIDS patients. (cdc.gov)
  • 21 children who have been admitted in an orphanage … More before 3 month of ages were tested for their antibodies to HHV-6. (nii.ac.jp)