A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and "classical" Kaposi sarcoma.
The type species of ROSEOLOVIRUS isolated from patients with AIDS and other LYMPHOPROLIFERATIVE DISORDERS. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter NK cell activity. HHV-6; (HBLV) antibodies are elevated in patients with AIDS, Sjogren's syndrome, sarcoidosis, chronic fatigue syndrome, and certain malignancies. HHV-6 is the cause of EXANTHEMA SUBITUM and has been implicated in encephalitis.
The type species of RHADINOVIRUS, in the subfamily GAMMAHERPESVIRINAE, isolated from squirrel monkeys. It produces malignant lymphomas (LYMPHOMA, MALIGNANT) in inoculated marmosets or owl monkeys.
A species of VARICELLOVIRUS causing abortion and respiratory disease in horses.
A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE.
A species of VARICELLOVIRUS that causes INFECTIOUS BOVINE RHINOTRACHEITIS and other associated syndromes in CATTLE.
Virus diseases caused by the HERPESVIRIDAE.
A species in the genus ROSEOLOVIRUS, of the family HERPESVIRIDAE. It was isolated from activated, CD4-positive T-lymphocytes taken from the blood of a healthy human.
A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting cattle.
A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
A species of VARICELLOVIRUS virus that causes a disease in newborn puppies.
The type species of the genus MARDIVIRUS in the family HERPESVIRIDAE. It is the etiologic agent of MAREK DISEASE, infecting domestic fowl and wild birds.
A species of VARICELLOVIRUS that causes a fatal MENINGOENCEPHALITIS in calves.
A species of VARICELLOVIRUS and the chief cause of rhinopneumonitis in horses.
Infection with ROSEOLOVIRUS, the most common in humans being EXANTHEMA SUBITUM, a benign disease of infants and young children.
A species of SIMPLEXVIRUS that causes vesicular lesions of the mouth in monkeys. When the virus is transmitted to man it causes an acute encephalitis or encephalomyelitis, which is nearly always fatal.
Proteins found in any species of virus.
A subfamily of HERPESVIRIDAE characterized by a short replication cycle. The genera include: SIMPLEXVIRUS; VARICELLOVIRUS; MAREK'S DISEASE-LIKE VIRUSES; and ILTOVIRUS.
A species of VARICELLOVIRUS producing a respiratory infection (PSEUDORABIES) in swine, its natural host. It also produces an usually fatal ENCEPHALOMYELITIS in cattle, sheep, dogs, cats, foxes, and mink.
A subfamily of HERPESVIRIDAE characterized by variable reproductive cycles. The genera include: LYMPHOCRYPTOVIRUS and RHADINOVIRUS.
Deoxyribonucleic acid that makes up the genetic material of viruses.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE. Its species include those causing CHICKENPOX and HERPES ZOSTER in humans (HERPESVIRUS 3, HUMAN), as well as several animal viruses.
A species of VARICELLOVIRUS causing coital exanthema in horses.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
A subfamily of HERPESVIRIDAE characterized by a relatively long replication cycle. Genera include: CYTOMEGALOVIRUS; MUROMEGALOVIRUS; and ROSEOLOVIRUS.
Established cell cultures that have the potential to propagate indefinitely.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
A species in the genus MAREK'S DISEASE-LIKE VIRUSES, in the family HERPESVIRIDAE, infecting turkeys.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Substances elaborated by viruses that have antigenic activity.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
The functional hereditary units of VIRUSES.
A species in the family AOTIDAE, inhabiting the forested regions of Central and South America (from Panama to the Amazon). Vocalizations occur primarily at night when they are active, thus they are also known as Northern night monkeys.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
The type species of the genus ILTOVIRUS found on every continent and affecting mainly chickens and occasionally pheasants.
The type species of VARICELLOVIRUS causing CHICKENPOX (varicella) and HERPES ZOSTER (shingles) in humans.
An acute, short-lived, viral disease of infants and young children characterized by a high fever at onset that drops to normal after 3-4 days and the concomitant appearance of a macular or maculopapular rash that appears first on the trunk and then spreads to other areas. It is the sixth of the classical exanthematous diseases and is caused by HHV-6; (HERPESVIRUS 6, HUMAN). (From Dorland, 27th ed)
A species of the family HERPESVIRIDAE, whose genus is so far unassigned. It is probably the causative agent of ADENOMA or ADENOCARCINOMA in the kidneys of certain frogs.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye.
Diseases of domestic and wild horses of the species Equus caballus.
A herpesvirus infection of CATTLE characterized by INFLAMMATION and NECROSIS of the mucous membranes of the upper RESPIRATORY TRACT.
A novel member of the tumor-necrosis factor receptor family that can also mediate HERPES SIMPLEX VIRUS TYPE 1 entry into cells. It has specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 and the homotrimeric form of LYMPHOTOXIN-ALPHA. The receptor is abundantly expressed on T-LYMPHOCYTES and may play a role in regulating lymphocyte activation. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
A subfamily in the family CEBIDAE that consists of four genera: CALLITHRIX (marmosets), CALLIMICO (Goeldi's monkey), LEONTOPITHECUS (lion tamarins), and SAGUINUS (long-tusked tamarins). The members of this family inhabit the tropical forests of South and Central America.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A herpesvirus infection of cattle characterized by catarrhal inflammation of the upper respiratory and alimentary epithelia, keratoconjunctivitis, encephalitis and lymph node enlargement. Syn: bovine epitheliosis, snotsiekte.
A species of SIMPLEXVIRUS associated with genital infections (HERPES GENITALIS). It is transmitted by sexual intercourse and close personal contact.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
A family of the New World monkeys inhabiting the forests of South and Central America. There is a single genus and several species occurring in this family, including AOTUS TRIVIRGATUS (Northern night monkeys).
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)
A species in the genus MAREK'S DISEASE-LIKE VIRUSES, in the family HERPESVIRIDAE, infecting chickens.
Any of various ruminant mammals of the order Bovidae. They include numerous species in Africa and the American pronghorn.
A highly contagious herpesvirus infection affecting the central nervous system of swine, cattle, dogs, cats, rats, and other animals.
Common name for a number of different species of fish in the family Cyprinidae. This includes, among others, the common carp, crucian carp, grass carp, and silver carp.
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Large woodland game BIRDS in the subfamily Meleagridinae, family Phasianidae, order GALLIFORMES. Formerly they were considered a distinct family, Melegrididae.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
A genus in the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, associated with malignancy in birds.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
Ribonucleic acid that makes up the genetic material of viruses.
A genus in the subfamily CALLITRICHINAE consisting of 12 species and found in Panama as well as South America. Species seen most frequently in the literature are S. oedipus (cotton-top marmoset), S. nigricollis, and S. fusicollis.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.
The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
The interactions between a host and a pathogen, usually resulting in disease.
A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Process of growing viruses in live animals, plants, or cultured cells.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
An unassigned genus in the family HERPESVIRIDAE, comprising one species Ictalurid herpesvirus 1 (Channel Catfish Virus).
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
A general term for various neoplastic diseases of the lymphoid tissue.
A genus of the subfamily CALLITRICHINAE occurring in forests of Brazil and Bolivia and containing seventeen species.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).
Genes that show rapid and transient expression in the absence of de novo protein synthesis. The term was originally used exclusively for viral genes where immediate-early referred to transcription immediately following virus integration into the host cell. It is also used to describe cellular genes which are expressed immediately after resting cells are stimulated by extracellular signals such as growth factors and neurotransmitters.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Diseases of animals within the order PRIMATES. This term includes diseases of Haplorhini and Strepsirhini.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
A member of tumor necrosis factor superfamily found on activated LYMPHOCYTES and MONOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to LYMPHOTOXIN BETA RECEPTOR and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A genus of the family CEBIDAE consisting of four species: S. boliviensis, S. orstedii (red-backed squirrel monkey), S. sciureus (common squirrel monkey), and S. ustus. They inhabit tropical rain forests in Central and South America. S. sciureus is used extensively in research studies.
A family of hoofed MAMMALS consisting of HORSES, donkeys, and zebras. Members of this family are strict herbivores and can be classified as either browsers or grazers depending on how they feed.
Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
A family of North American freshwater CATFISHES. It consists of four genera (Ameiurus, Ictalurus, Noturus, Pylodictis,) comprising several species, two of which are eyeless.
Premature expulsion of the FETUS in animals.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Methods used by pathogenic organisms to evade a host's immune system.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Nucleotide sequences repeated on both the 5' and 3' ends of a sequence under consideration. For example, the hallmarks of a transposon are that it is flanked by inverted repeats on each end and the inverted repeats are flanked by direct repeats. The Delta element of Ty retrotransposons and LTRs (long terminal repeats) are examples of this concept.
The process by which a DNA molecule is duplicated.
A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The relationships of groups of organisms as reflected by their genetic makeup.
A genus of the family Bovidae having two species: B. bison and B. bonasus. This concept is differentiated from BUFFALOES, which refers to Bubalus arnee and Syncerus caffer.
Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The semilunar-shaped ganglion containing the cells of origin of most of the sensory fibers of the trigeminal nerve. It is situated within the dural cleft on the cerebral surface of the petrous portion of the temporal bone and gives off the ophthalmic, maxillary, and part of the mandibular nerves.
Immune status consisting of non-production of HIV antibodies, as determined by various serological tests.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Viruses whose nucleic acid is DNA.
An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
A genus of tree shrews of the family TUPAIIDAE which consists of about 12 species. One of the most frequently encountered species is T. glis. Members of this genus inhabit rain forests and secondary growth areas in southeast Asia.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.
Cultivation of natural faunal resources of water. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
A genus of the family HYLOBATIDAE consisting of six species. The members of this genus inhabit rain forests in southeast Asia. They are arboreal and differ from other anthropoids in the great length of their arms and very slender bodies and limbs. Their major means of locomotion is by swinging from branch to branch by their arms. Hylobates means dweller in the trees. Some authors refer to Symphalangus and Nomascus as Hylobates. The six genera include: H. concolor (crested or black gibbon), H. hoolock (Hoolock gibbon), H. klossii (Kloss's gibbon; dwarf siamang), H. lar (common gibbon), H. pileatus (pileated gibbon), and H. syndactylus (siamang). H. lar is also known as H. agilis (lar gibbon), H. moloch (agile gibbon), and H. muelleri (silvery gibbon).
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Serologic tests in which a positive reaction manifested by visible CHEMICAL PRECIPITATION occurs when a soluble ANTIGEN reacts with its precipitins, i.e., ANTIBODIES that can form a precipitate.
An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
A species of the genus VESIVIRUS infecting cats. Transmission occurs via air and mechanical contact.
A benign tumor of fibrous or fully developed connective tissue.
Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.
One of the Type II site-specific deoxyribonucleases (EC It recognizes and cleaves the sequence A/AGCTT at the slash. HindIII is from Haemophilus influenzae R(d). Numerous isoschizomers have been identified. EC 3.1.21.-.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A genus of the family HERPESVIRIDAE, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans and new world primates. The type species human herpesvirus 4 (HERPESVIRUS 4, HUMAN) is better known as the Epstein-Barr virus.
One of the Type II site-specific deoxyribonucleases (EC It recognizes and cleaves the sequence G/GATCC at the slash. BamHI is from Bacillus amyloliquefaciens N. Numerous isoschizomers have been identified. EC 3.1.21.-.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
A cell line generated from human embryonic kidney cells that were transformed with human adenovirus type 5.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Antibodies produced by a single clone of cells.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

Deletion of multiple immediate-early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons. (1/3695)

Herpes simplex virus type 1 (HSV-1) has many attractive features that suggest its utility for gene transfer to neurons. However, viral cytotoxicity and transient transgene expression limit practical applications even in the absence of viral replication. Mutant viruses deleted for the immediate early (IE) gene, ICP4, an essential transcriptional transactivator, are toxic to many cell types in culture in which only the remaining IE genes are expressed. In order to test directly the toxicity of other IE gene products in neurons and develop a mutant background capable of longterm transgene expression, we generated mutants deleted for multiple IE genes in various combinations and tested their relative cytotoxicity in 9L rat gliosarcoma cells, Vero monkey kidney cells, and primary rat cortical and dorsal root neurons in culture. Viral mutants deleted simultaneously for the IE genes encoding ICP4, ICP22 and ICP27 showed substantially reduced cytotoxicity compared with viruses deleted for ICP4 alone or ICP4 in combination with either ICP22, ICP27 or ICP47. Infection of neurons in culture with these triple IE deletion mutants substantially enhanced cell survival and permitted transgene expression for over 21 days. Such mutants may prove useful for efficient gene transfer and extended transgene expression in neurons in vitro and in vivo.  (+info)

Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins. (2/3695)

The PML protein is associated to nuclear bodies (NBs) whose functions are as yet unknown. PML and two other NBs-associated proteins, Sp100 And ISG20 are directly induced by interferons (IFN). PML and Sp100 proteins are covalently linked to SUMO-1, and ubiquitin-like peptide. PML NBs are disorganized in acute promyelocytic leukemia and during several DNA virus infections. In particular, the HSV-1 ICP0 protein is known to delocalize PML from NBs. Thus, NBs could play an important role in oncogenesis, IFN response and viral infections. Here, we show that HSV-1 induced PML protein degradation without altering its mRNA level. This degradation was time- and multiplicity of infection-dependent. Sp100 protein was also degraded, while another SUMO-1 conjugated protein, RanGAP1 and the IFN-induced protein kinase PKR were not. The proteasome inhibitor MG132 abrogated the HSV-1-induced PML and Sp100 degradation and partially restored their NB-localization. HSV-1 induced PML and Sp100 degradation constitutes a new example of viral inactivation of IFN target gene products.  (+info)

Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. (3/3695)

We are developing quantitative assays to repeatedly and noninvasively image expression of reporter genes in living animals, using positron emission tomography (PET). We synthesized positron-emitting 8-[18F]fluoroganciclovir (FGCV) and demonstrated that this compound is a substrate for the herpes simplex virus 1 thymidine kinase enzyme (HSV1-TK). Using positron-emitting FGCV as a PET reporter probe, we imaged adenovirus-directed hepatic expression of the HSV1-tk reporter gene in living mice. There is a significant positive correlation between the percent injected dose of FGCV retained per gram of liver and the levels of hepatic HSV1-tk reporter gene expression (r2 > 0.80). Over a similar range of HSV1-tk expression in vivo, the percent injected dose retained per gram of liver was 0-23% for ganciclovir and 0-3% for FGCV. Repeated, noninvasive, and quantitative imaging of PET reporter gene expression should be a valuable tool for studies of human gene therapy, of organ/cell transplantation, and of both environmental and behavioral modulation of gene expression in transgenic mice.  (+info)

Characterization of the interaction between the herpes simplex virus type I Fc receptor and immunoglobulin G. (4/3695)

Herpes simplex virus type I (HSV-1) virions and HSV-1-infected cells bind to human immunoglobulin G (hIgG) via its Fc region. A complex of two surface glycoproteins encoded by HSV-1, gE and gI, is responsible for Fc binding. We have co-expressed soluble truncated forms of gE and gI in Chinese hamster ovary cells. Soluble gE-gI complexes can be purified from transfected cell supernatants using a purification scheme that is based upon the Fc receptor function of gE-gI. Using gel filtration and analytical ultracentrifugation, we determined that soluble gE-gI is a heterodimer composed of one molecule of gE and one molecule of gI and that gE-gI heterodimers bind hIgG with a 1:1 stoichiometry. Biosensor-based studies of the binding of wild type or mutant IgG proteins to soluble gE-gI indicate that histidine 435 at the CH2-CH3 domain interface of IgG is a critical residue for IgG binding to gE-gI. We observe many similarities between the characteristics of IgG binding by gE-gI and by rheumatoid factors and bacterial Fc receptors such as Staphylococcus aureus protein A. These observations support a model for the origin of some rheumatoid factors, in which they represent anti-idiotypic antibodies directed against antibodies to bacterial and viral Fc receptors.  (+info)

Macrophage control of herpes simplex virus type 1 replication in the peripheral nervous system. (5/3695)

After corneal infection, herpes simplex virus type 1 (HSV-1) invades sensory neurons with cell bodies in the trigeminal ganglion (TG), replicates briefly, and then establishes a latent infection in these neurons. HSV-1 replication in the TG can be detected as early as 2 days after corneal infection, reaches peak titers by 3-5 days after infection, and is undetectable by 7-10 days. During the period of HSV-1 replication, macrophages and gammadelta TCR+ T lymphocytes infiltrate the TG, and TNF-alpha, IFN-gamma, the inducible nitric oxide synthase (iNOS) enzyme, and IL-12 are expressed. TNF-alpha, IFN-gamma, and the iNOS product nitric oxide (NO) all inhibit HSV-1 replication in vitro. Macrophage and gammadelta TCR+ T cell depletion studies demonstrated that macrophages are the main source of TNF-alpha and iNOS, whereas gammadelta TCR+ T cells produce IFN-gamma. Macrophage depletion, aminoguanidine inhibition of iNOS, and neutralization of TNF-alpha or IFN-gamma all individually and synergistically increased HSV-1 titers in the TG after HSV-1 corneal infection. Moreover, individually depleting macrophages or neutralizing TNF-alpha or IFN-gamma markedly reduced the accumulation of both macrophages and gammadelta TCR+ T cells in the TG. Our findings establish that after primary HSV-1 infection, the bulk of virus replication in the sensory ganglia is controlled by macrophages and gammadelta TCR+ T lymphocytes through their production of antiviral molecules TNF-alpha, NO, and IFN-gamma. Our findings also strongly suggest that cross-regulation between these two cell types is necessary for their accumulation and function in the infected TG.  (+info)

The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells. (6/3695)

The herpes simplex virus type 1 (HSV-1) ICP27 protein is an immediate-early or alpha protein which is essential for the optimal expression of late genes as well as the synthesis of viral DNA in cultures of Vero cells. Our specific goal was to characterize the replication of a virus incapable of synthesizing ICP27 in cultured human cells. We found that infection with an HSV-1 ICP27 deletion virus of at least three separate strains of human cells did not produce immediate-early or late proteins at the levels observed following wild-type virus infections. Cell morphology, chromatin condensation, and genomic DNA fragmentation measurements demonstrated that the human cells died by apoptosis after infection with the ICP27 deletion virus. These features of the apoptosis were identical to those which occur during wild-type infections of human cells when total protein synthesis has been inhibited. Vero cells infected with the ICP27 deletion virus did not exhibit any of the features of apoptosis. Based on these results, we conclude that while HSV-1 infection likely induced apoptosis in all cells, viral evasion of the response differed among the cells tested in this study.  (+info)

Visualization of tegument-capsid interactions and DNA in intact herpes simplex virus type 1 virions. (7/3695)

Herpes simplex virus type 1 virions were examined by electron cryomicroscopy, allowing the three-dimensional structure of the infectious particle to be visualized for the first time. The capsid shell is identical to that of B-capsids purified from the host cell nucleus, with the exception of the penton channel, which is closed. The double-stranded DNA genome is organized as regularly spaced ( approximately 26 A) concentric layers inside the capsid. This pattern suggests a spool model for DNA packaging, similar to that for some bacteriophages. The bulk of the tegument is not icosahedrally ordered. However, a small portion appears as filamentous structures around the pentons, interacting extensively with the capsid. Their locations and interactions suggest possible roles for the tegument proteins in regulating DNA transport through the penton channel and binding to cellular transport proteins during viral infection.  (+info)

Herpes simplex virus 1 blocks caspase-3-independent and caspase-dependent pathways to cell death. (8/3695)

Earlier reports have shown that herpes simplex virus 1 (HSV-1) mutants induce programmed cell death and that wild-type HSV blocks the execution of the cell death program triggered by viral gene products, by the effectors of the immune system such as the Fas and tumor necrosis factor pathways, or by nonspecific stress agents such as either osmotic shock induced by sorbitol or thermal shock. A report from this laboratory showed that caspase inhibitors do not block DNA fragmentation induced by infection with the HSV-1 d120 mutant. To identify the events in programmed cell death induced and blocked by HSV-1, we examined cells infected with wild-type virus or the d120 mutant or cells infected and exposed to sorbitol. We report that: (i) the HSV-1 d120 mutant induced apoptosis by a caspase-3-independent pathway inasmuch as caspase 3 was not activated and DNA fragmentation was not blocked by caspase inhibitors even though the virus caused cytochrome c release and depolarization of the inner mitochondrial membrane. (ii) Cells infected with wild-type HSV-1 exhibited none of the manifestations associated with programmed cell death assayed in these studies. (iii) Uninfected cells exposed to osmotic shock succumbed to caspase-dependent apoptosis inasmuch as cytochrome c was released, the inner mitochondrial potential was lost, caspase-3 was activated, and chromosomal DNA was fragmented. (iv) Although caspase-3 was activated in cells infected with wild-type HSV-1 and exposed to sorbitol, cytochrome c outflow, depolarization of the inner mitochondrial membrane, and DNA fragmentation were blocked. We conclude that although d120 induces apoptosis by a caspase-3-independent pathway, the wild-type virus blocks apoptosis induced by this pathway and also blocks the caspase-dependent pathway induced by osmotic shock. The block in the caspase-dependent pathway may occur downstream of caspase-3 activation.  (+info)

TY - JOUR. T1 - Identification of herpes simplex virus type 1 proteins encoded within the first 1.5 kb of the latency-associated transcript. AU - Henderson, Gail. AU - Jaber, Tareq. AU - Carpenter, Dale. AU - Wechsler, Steven L.. AU - Jones, Clinton. PY - 2009/12/12. Y1 - 2009/12/12. N2 - Expression of the first 1.5 kb of the latency-associated transcript (LAT) that is encoded by herpes simplex virus type 1 (HSV-1) is sufficient for wild-type (wt) levels of reactivation from latency in small animal models. Peptide-specific immunoglobulin G (IgG) was generated against open reading frames (ORFs) that are located within the first 1.5 kb of LAT coding sequences. Cells stably transfected with LAT or trigeminal ganglionic neurons of mice infected with a LAT expressing virus appeared to express the L2 or L8 ORF. Only L2 ORF expression was readily detected in trigeminal ganglionic neurons of latently infected mice.. AB - Expression of the first 1.5 kb of the latency-associated transcript (LAT) that is ...
The wild-type herpes simplex virus type-1 (HSV-1) is an enveloped, double-stranded DNA virus. Nearly half of its 152-kb viral genome sequence is nonessential for viral replication. Theoretically, a HSV-1 vector can be built to carry a 76-kb foreign DNA sequence without compromising viral replication. In the laboratory, recombinant HSV-1 vectors with a 38-kb packaging capacity have been generated (reviewed in (Burton et al. 2002; Glorioso et al. 1997; Goins et al. 2004; Huard et al. 1997b)). Early experimentation with HSV-1 vectors demonstrated quite efficient myoblast transduction in vitro. However, direct muscle injection only yielded transient, restricted expression (Akkaraju et al. 1999; Huard et al., 1995, 1996, 1997a).. A variant of the HSV-1 vector called an amplicon has also been investigated for gene transfer. HSV-1 amplicons only contain ~1% of the wild-type viral sequences encoding the HSV replication origin and the packaging signal (reviewed in (Hibbitt and Wade-Martins 2006; Link et ...
Laimbacher, A S; Fraefel, C (2014). HSV-1 Amplicon Vectors as Genetic Vaccines. In: Diefenbach, R J; Fraefel, C. Herpes Simplex Virus. New York: Springer, 99-115.. Melendez, M E; Fraefel, C; Epstein, A L (2014). Herpes Simplex Virus Type 1 (HSV-1)-Derived Amplicon Vectors. In: Diefenbach, R J; Fraefel, C. Herpes Simplex Virus. New York: Springer, 81-89.. Kelly, B J; Diefenbach, E; Fraefel, C; Diefenbach, R J (2012). Identification of host cell proteins which interact with herpes simplex virus type 1 tegument protein pUL37. Biochemical and Biophysical Research Communications (BBRC), 417(3):961-965.. Kelly, B J; Mijatov, Branka; Fraefel, C; Cunningham, A L; Diefenbach, R J (2011). Identification of a single amino acid residue which is critical for the interaction between HSV-1 inner tegument proteins pUL36 and pUL37. Virology:1-9.. Kelly, B J; Fraefel, C; Cunningham, A L; Diefenbach, R J (2009). Functional roles of the tegument proteins of herpes simplex virus type 1. Virus Research, ...
Buy our Recombinant herpes simplex virus HHV8 ORF8+ORF65 protein. Ab67704 is an active protein fragment produced in Escherichia coli and has been validated in…
The work presented in this thesis is concerned with the characterisation of the UL32 gene of herpes simplex virus type 1 (HSV-1). UL32 encodes an essential 596 amino acid cysteine-rich, zinc-binding protein that is highly conserved throughout the herpesviruses. The UL32 protein is essential for the cleavage of concatemeric viral DNA into monomeric genomes and their packaging into preformed capsids. Conservation is highest at the C-terminus and three CxxC motifs are present in almost all known herpesvirus UL32 sequences The UL32 antibodies available in the laboratory at the beginning of the project were incapable of detecting small amounts of UL32 protein and so new rabbit antisera were created. Soluble extracts from insect cells infected with a UL32-expressing baculovirus (AcUL32) were fractionated by anion exchange chromatography and the UL32-containing fractions used to immunise rabbits. The resultant antisera successfully recognised UL32 from transfected, HSV-1 infected and baculovirus ...
G207, a mutant herpes simplex virus (HSV) type 1, is safe when inoculated into recurrent malignant glioma. We conducted a phase 1 trial of G207 to demonstrate the safety of stereotactic intratumoral administration when given 24 hours prior to a single 5 Gy radiation dose in patients with recurrent m …
BioAssay record AID 85865 submitted by ChEMBL: Compound was tested for the antiviral activity against herpes simplex virus-1 (HSV-1) KOS strain.
1KI2: Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
1KIM: Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Although many tegument proteins have been found to be important for viral replication, very little has been done to elucidate the network of interactions that connect them. Of the ∼20 HSV-1 proteins that constitute the tegument, only three capsid-tegument (26, 31, 40), four tegument-tegument (11, 36, 44), and two tegument-glycoprotein (30, 45) interactions have been identified. Similarly, very few interactions have been identified among the tegument proteins of other alphaherpesviruses, such as PRV (13, 20) and varicella-zoster virus (23, 38, 39). As a result, the structural organization and function of most herpesvirus virion proteins still remain a mystery.. The goal of the present study was to identify and characterize binding partners for membrane-bound tegument protein UL11. In addition to several minor protein species, an abundant 40-kDa protein appeared to strongly associate with UL11 in both immunoprecipitation and GST pull-down assays. Based only on its size and evidence that ...
Candidate tegument proteins.The tegument is a complex structure which contains at least 18 different viral proteins (32). The functions of most of these and their structural relationships within the tegument are still poorly defined; however, a number of them have been shown to be nonessential for virus replication and therefore seem unlikely to be candidates to form the major connection between tegument and capsid. Earlier morphological and biochemical studies provide some indications regarding which tegument protein is being resolved in our reconstruction of the intact virion.. Biochemically, the essential tegument protein VP1-3 has been shown to bind very tightly to the capsid. Thus, detergent treatment of virions removes the envelope and solubilizes some tegument proteins but leaves others (notably VP1-3) in an insoluble, capsid/tegument fraction (31, 36), while more vigorous treatment results in the loss of virtually all envelope and tegument proteins except for VP1-3 (14). Since it has ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
In the reproduction of HSV-1, the temporal profile of the viral gene expressions and the molecular mechanisms regulating the expressions are extensively studied. Functional roles of the temporally ordered gene expressions has not yet been clarified. We construct a simple mathematical model for the intracellular replication of HSV-1 to investigate the function of the ordered gene expressions. We obtain the condition for the explosion of the virus from our model. The expression ratio of the early gene to the late gene must be higher than the ratio of the reaction rate of the encapsidation to that of the viral DNA replication for viruses to reproduce successfully. The preceded accumulation of the early gene product prevents the growth arrest. Further, as promoter activity of the early gene becomes higher, the replication speed of virus becomes faster. The structure of early gene promoter that has many binding motif to transcription factor accelerates the replication speed of HSV-1. This structure ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
By downloading, copying, or making any use of the images located on this website (Site) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below. If you do not agree to such terms, do not download, copy or use the images in any way, unless you have written permission signed by an authorized Pacific Biosciences representative.. Subject to the terms of this Agreement and the terms provided on the Legal Notices webpage (to the extent they do not conflict with the terms of this Agreement), you may use the images on the Site solely for (a) editorial use by press and/or industry analysts, (b) in connection with a normal, peer-reviewed, scientific publication, book or presentation, or the like. You may not alter or modify any image, in whole or in part, for any reason. You may not use any image in a manner that misrepresents the ...
The molecular modifications of Herpes Simplex Virus Type I (HSV-1) proteins represented by acetylation and phosphorylation are essential to its biological functions. The cellular chromatin-remodeling/ assembly is involved in HSV-1 associated gene transcriptional regulation in human cells harboring HSV-1 lytic or latent infections. Further investigation on these biological events would provide a better understanding of the mechanisms of HSV-1 viral gene transcriptional regulation
Metrick, C.M., Koenigsberg, A.L., Heldwein, E.E. (2020) Conserved outer-tegument component UL11 from herpes simplex virus type 1 is an intrinsically disordered, RNA-binding protein. mBio. https://mbio.asm.org/content/11/3/e00810-20.. ​. Koenigsberg, A.L., Pitts, J.D. and Heldwein, E.E. (2020). Identification of buffer conditions for optimal thermostability and solubility of herpesviral protein UL37 using the Thermofluor assay. Bio-protocol. 10: e3662. doi: 10.21769/BioProtoc.3662. ​. ​​​​. 2019. ​. Hilterbrand, A.T. and Heldwein, E.E. (2019) Go go gadget glycoprotein!: HSV-1 draws on its sizeable glycoprotein tool kit to customize its diverse entry routes. PLoS Pathog. 15(5), e1007660. PMC6508585.. ​. ​. 2018. ​. Koenigsberg, A.L., and Heldwein, E.E. (2018) The dynamic nature of the conserved tegument protein UL37 of herpesviruses. J. Biol Chem. 293(41), 15827-15839. PMC6187633.. ​. Cooper R.S, Georgieva E.R., Borbat P.P., Freed J.H., Heldwein E.E. (2018) Structural basis ...
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2021 Elsevier B.V. We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. ...
Antitumor effects of oncolytic herpes simplex virus type 2 against colorectal cancer in vitro and in vivo Lei Yin,1–3 Chunhong Zhao,3 Jixia Han,4 Zengjun Li,2 Yanan Zhen,3 Ruixue Xiao,3 Zhongfa Xu,3 Yanlai Sun2 1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 2Department of Gastrointestinal Cancer Surgery, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, 3Department of Gastrointestinal Surgery, The Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, 4Department of General Surgery, The Sixth People’s Hospital of Jinan, Jinan, People’s Republic of China Background: The incidence of colorectal cancer (CRC) is on the rise. Furthermore, late-stage diagnoses and limited efficacious treatment options make CRC a complex clinical challenge. Therefore, a new therapeutic regimen with a completely novel therapeutic mechanism is necessary for CRC. In the present study, the
TY - JOUR. T1 - Herpes simplex virus capsids are transported in neuronal axons without an envelope containing the viral glycoproteins. AU - Snyder, Aleksandra. AU - Wisner, Todd W.. AU - Johnson, David. PY - 2006/11. Y1 - 2006/11. N2 - Electron micrographic studies of neuronal axons have produced contradictory conclusions on how alpha-herpesviruses are transported from neuron cell bodies to axon termini. Some reports have described unenveloped capsids transported on axonal microtubules with separate transport of viral glycoproteins within membrane vesicles. Others have observed enveloped virions in proximal and distal axons. We characterized transport of herpes simplex virus (HSV) in human and rat neurons by staining permeabilized neurons with capsid- and glycoprotein-specific antibodies. Deconvolution microscopy was used to view 200-nm sections of axons. HSV glycoproteins were very rarely associated with capsids (3 to 5%) and vice versa. Instances of glycoprotein/capsid overlap frequently ...
Objectives: To document the natural history of herpes simplex virus type 2 (HSV-2) in relation to HIV and highly active antiretroviral therapy (HAART) in Africa, a longitudinal study was conducted of women in the placebo arms of two randomised controlled trials of HSV-suppressive therapy in Burkina Faso. Methods: 22 HIV-uninfected women (group 1), 30 HIV-1-infected women taking HAART (group 2), and 68 HIV-1-infected women not eligible for HAART (group 3) were followed over 24 weeks. HSV-2 DNA was detected on alternate weeks using real-time PCR from cervicovaginal lavages. Plasma HIV-1 RNA was measured every month. CD4 cell counts were measured at enrolment. Results: Ulcers occurred on 1.9%, 3.1% and 7.2% of visits in groups 1, 2 and 3 (p = 0.02). Cervicovaginal HSV-2 DNA was detected in 45.5%, 63.3% and 67.6% of women (p = 0.11), and on 4.3%, 9.7% and 15.5% of visits in the three groups (p ...
Herpes simplex virus type 2 (HSV-2) is a known biologic cofactor for human immunodeficiency virus (HIV) transmission and acquisition. The Kenya AIDS Indicator Survey 2007 provided Kenyas first nationally representative estimate of HSV-2 prevalence and risk factors. METHODS: KAIS was a household serosurvey among women and men aged 15 to 64 years. The survey included a behavioral interview and serum testing for HSV-2, HIV, and syphilis infections. Results were weighted for sampling design and nonresponse. RESULTS: Of 19,840 eligible individuals, 90% completed an interview and 80% consented to testing. In all, 35% were infected with HSV-2, of which 42% were women and 26% were men. Between 15 and 24 years of age, HSV-2 prevalence increased from 7% to 34% in women and 3% to 14% in men. Among couples, 30% were HSV-2 concordant-positive, 21% were discordant, and 49% were concordant-negative. In all, 81% of HIV-infected persons were coinfected with HSV-2. HIV prevalence was 16% among those with HSV-2 ...
Gentaur molecular products has all kinds of products like :search , GeneRiver \ Human Herpes Simplex Virus 1 \ FR018 for more molecular products just contact us
TY - JOUR. T1 - Latent herpes simplex virus-1 infection in SCID mice transferred with immune CD4+T cells. T2 - A new model for latency. AU - Minagawa, H.. AU - Yanagi, Y.. PY - 2000. Y1 - 2000. N2 - In C.B-17 severe combined immunodeficiency (SCID) mice, corneal challenge with herpes simplex virus-1 (HSV-1) KOS strain usually leads to fatal encephalitis. With the transfer of T cells from immunized BALB/c mice, these SCID mice developed a latent HSV-1 infection. In order to determine the responsible T cell subset, fractionated immune T cells were transferred. Those SCID mice transferred with immune CD4+T cell-enriched fraction developed latent HSV-1 infection in their trigeminal ganglia. Their splenocytes had an increased percentage of CD4+T cells and showed a proliferative response against HSV-1. The transfer of CD8+T cells increased survival in the acute infection, but their engraftment seemed less needed for latency than that of CD4+T cells. Mice that received immune serum survived without ...
Herpes simplex virus ICP27 protein. Computer model showing the structure of Herpes simplex virus 1 protein ICP27, a multifunctional regulatory protein (purple, magenta). - Stock Image C035/6254
Cyclic GMP-AMP synthase (cGAS) is a key DNA sensor capable of detecting microbial DNA and activating the adaptor protein stimulator of interferon genes (STING), leading to interferon (IFN) production and host antiviral responses. Cells exhibited reduced type I IFN production in response to cytosolic DNA in the absence of cGAS. Although the cGAS/STING-mediated DNA-sensing signal is crucial for host defense against many viruses, especially for DNA viruses, few viral components have been identified to specifically target this signaling pathway. Herpes simplex virus 1 (HSV-1) is a DNA virus that has evolved multiple strategies to evade host immune responses. In the present study, we found that HSV-1 tegument protein UL41 was involved in counteracting the cGAS/STING-mediated DNA-sensing pathway. Our results showed that wild-type (WT) HSV-1 infection could inhibit immunostimulatory DNA-induced activation of the IFN signaling pathway compared with the UL41-null mutant virus (R2621), and ectopic expression of
After replication at sites of initial inoculation, herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) establish lifelong latent infections of the sensory and autonomic neurons of the ganglia serving those sites. Periodically, the virus reactivates from these neurons, and travels centripetally along the neuronal axon to cause recurrent epithelial infection. The major clinically observed difference between infections with herpes simplex virus type 1 and type 2 is the anatomic site specificity of recurrence. HSV-1 reactivates most efficiently and frequently from trigeminal ganglia, causing recurrent ocular and oral-facial lesions, while HSV-2 reactivates primarily from sacral ganglia causing recurrent genital lesions. An intertypic recombinant virus was constructed and evaluated in animal models of recurrent ocular and genital herpes. Substitution of a 2.8-kbp region from the HSV-1 latency-associated transcript (LAT) for native HSV-2 sequences caused HSV-2 to reactivate with an HSV-1 phenotype in ...
Herpes simplex virus type 1 (HSV-1) is a human pathogen which belongs to the family Herpesviridae. HSV-1 encodes several genes, which serve to efficiently prevent apoptosis in most infected cell types, thereby ensuring successful virus replication. In contrast, HSV-1 infection of one central cell type of the immune system, immature dendritic cells (iDCs), results in apoptosis. This could be one aspect of HSV-1 immunevasion. So far, the mechanisms underlying apoptosis of HSV-1 infected iDCs were poorly defined. However, it has been shown that the antiapoptotic cellular protein c-FLIP is reduced in HSV-1 infected iDCs. In this work, the amount of c-FLIP was for the first time successfully reduced in iDCs by RNA interference. This confirmed the importance of c-FLIP for viability of iDCs. Therefore, it is likely that c-FLIP reduction after HSV-1 infection also sensitizes iDCs to apoptosis. HSV-1 induced c-FLIP reduction occurred at late stages of infection and was dependent on proper expression of ...
Varicella-zoster virus (VZV) gene 62 encodes a protein with a predicted M r of 140000 (VZV 140K) that shares considerable amino acid homology with the immediate early (IE) regulatory protein Vmw175 of herpes simplex virus type 1 (HSV-1) and is believed to be its functional equivalent. We have tested this hypothesis by insertion of VZV gene 62 (expressed from the HSV-1 IE3 promoter) into both IE3 gene loci in the short region repeats of the HSV-1 genome. The parent virus used for this manipulation was D30EBA, which is a variant of HSV-1 from which the majority of the Vmw175 coding sequences have been deleted. Like other HSV-1 viruses lacking Vmw175 function, D30EBA is able to grow only in cell lines which express Vmw175 constitutively. The resulting recombinant virus, HSV-140, is able to propagate (but unable to form obvious plaques) on normal cell lines. The properties of HSV-140 were studied by monitoring the time course of polypeptide expression and DNA replication during normal infection. We found
The human parvovirus Adeno-Associated Virus (AAV) type 2 can only replicate in cells co-infected with a helper virus, such as Adenovirus or Herpes Simplex Virus type 1 (HSV-1); whereas, in the absence of a helper virus, it establishes a latent infection. Previous studies demonstrated that the ternary HSV-1 helicase/primase (HP) complex (UL5/8/52) and the singlestranded DNA-Binding Protein (ICP8) were sufficient to induce AAV-2 replication in transfected cells. We independently showed that, in the context of a latent AAV-2 infection, the HSV-1 ICP0 protein was able to activate rep gene expression. The present study was conducted to integrate these observations and to further explore the requirement of other HSV-1 proteins during early AAV replication steps, i.e. rep gene expression and AAV DNA replication. Using a cellular model that mimics AAV latency and composite constructs coding for various sets of HSV-1 genes, we first confirmed the role of ICP0 for rep gene expression and demonstrated a ...
Background: Herpes simplex virus type 2 (HSV-2) is sexually transmitted, leading to blisters and ulcers in the genito-anal region. After primary infection the virus is present in a latent state in neurons in sensory ganglia. Reactivation and production of new viral particles can cause asymptomatic viral shedding or new lesions. Establishment of latency, maintenance and reactivation involve silencing of genes, continuous suppression of gene activities and finally gene activation and synthesis of viral DNA. The purpose of the present work was to study the genetic stability of the virus during these events.. Methods: HSV-2 was collected from 5 patients with true primary and recurrent infections, and the genes encoding glycoproteins B,G,E and I were sequenced.. Results: No nucleotide substitution was observed in any patient, indicating genetic stability. However, since the total number of nucleotides in these genes is only a small part of the total genome, we cannot rule out variation in other ...
Herpes simplex virus type-2 (HSV-2) is the primary cause of genital ulcers and one of the most prevalent sexually transmitted diseases worldwide. Consistently, over 30 studies have found HSV-2 infection to be a risk factor for HIV acquisition with an overall relative risk of 2.1 in the studies that demonstrated HSV-2 preceded HIV infection. A recent study of HIV-discordant couples from Rakai, Uganda, has shown that at all levels of HIV viral load in the HIV-positive partner, HSV-2 infection in the susceptible partner increased the per-contact risk of acquisition of HIV five-fold, and GUD in the HIV-source partner increased the per-contact risk of HIV transmission five-fold. As strong as these epidemiological data are, an intervention trial is required to define the clinical and public health significance of these findings.. This trial will directly answer the extent to which HSV-2 infection increases infectiousness of HIV/HSV-2 co-infected persons and the relative reduction in HIV transmission ...
Herpes simplex virus type-2 (HSV-2) is the primary cause of genital ulcers and one of the most prevalent sexually transmitted diseases worldwide. Consistently, over 30 studies have found HSV-2 infection to be a risk factor for HIV acquisition with an overall relative risk of 2.1 in the studies that demonstrated HSV-2 preceded HIV infection. A recent study of HIV-discordant couples from Rakai, Uganda, has shown that at all levels of HIV viral load in the HIV-positive partner, HSV-2 infection in the susceptible partner increased the per-contact risk of acquisition of HIV five-fold, and GUD in the HIV-source partner increased the per-contact risk of HIV transmission five-fold. As strong as these epidemiological data are, an intervention trial is required to define the clinical and public health significance of these findings.. This trial will directly answer the extent to which HSV-2 infection increases infectiousness of HIV/HSV-2 co-infected persons and the relative reduction in HIV transmission ...
Summary We have determined the DNA sequence of the herpes simplex virus type 1 (HSV-1) gene encoding the immediate early protein IE110, which is involved in transcriptional activation of later virus genes. The locations of the 5′ and 3′ termini of IE110 mRNA, together with the positions of two introns, were identified. Examination of the DNA sequence suggested that translation starts at the first ATG after the 5′ terminus of the mRNA, and that both introns occur in protein-coding sequence. The predicted IE110 polypeptide contains 775 amino acids, and has a molecular weight of 78452. It contains a cysteine-rich region resembling regions found in several proteins which interact functionally with DNA. An antiserum was raised to the predicted C terminal amino acid sequence of the IE110 polypeptide and was shown to immunoprecipitate the native protein from HSV-1-infected cell extracts. The functional importance of regions of the protein was evaluated by construction of frameshift and deletion mutants
Herpes Simplex Virus Type 1 (HSV-1) Antibody Test Kit - IgM,Inverness Medical Professional Diagnostics is a leading provider of immunofluorescence assays, with an extensive IFA and DFA test menu that includes kits for autoimmune diseases, infectious diseases and STDs as well as miscellaneous conjugates and components. Our Impact IFA Test Systems give you a,medicine,medical supply,medical supplies,medical product
Abcam provides general protocols for Human Anti-Herpes simplex virus Type 1 and 2 IgM ELISA Kit (HSV1+2) (ab108742). Please download our pdf protocol booklet
In this study, we present inhibitor- and siRNA-based strategies to interfere with autophagic flux in Herpes simplex virus type-1...
Abstract: : Purpose:We have demonstrated that CD8+ T cells that are present in herpes simplex virus type 1 (HSV-1) latently infected mouse trigeminal ganglia (TG) can block HSV-1 reactivation from latency, at least in part through the production of interferon gamma (IFN-g). Here we define the epitope specificity of these CD8+ T cells. Methods:At 14 and 34 days after corneal infection with the RE strain of HSV-1, the latently infected TG were removed, digested with collagenase, and the phenotype and function of CD8+ T cells in the TG cell suspension was determined by flow cytometry. The cells were stained for CD8, HSV-1 glycoprotein B (gB [aa 498-505]) tetramer, or HSV-1 ribonucleotide reductase (RR1 [aa 822-829]) tetramer, and/or intracellular IFN-g. Staining was performed on CD8 cells freshly isolated from the TG or following 5 hours of stimulation with syngeneic epithelial cells that were uninfected, HSV-1 infected, gB peptide pulsed, or RR1 peptide pulsed. Results:CD8 T cells in day 14 TG: ...
Oral and genital herpes are caused by the herpes simplex virus type 1 (HSV-1) and the herpes simplex virus type 2 (HSV-2), which both cause lifelong infection. HSV-2 infection is associated with increased risk for HIV infection. HSV2-infected women pose a risk of transmitting this dangerous infection to newborn babies; therefore, avoiding herpes infection during pregnancy is very important. In this issue of JCI Insight, researchers from the Albert Einstein College of Medicine report a promising vaccine strategy for immunizing against both HSV-1 and HSV-2 infections. Led by Betsy Herold and William Jacobs Jr., the researchers expanded upon previous work from their group indicating that a vaccine made from an engineered HSV-2 virus that lacks expression of glycoprotein D could protect against infection with a single strain of HSV-2 in mice. The current report shows that vaccination protects mice from multiple clinical isolates of HSV-1 and HSV-2 infection. Mice rapidly cleared virus after ...
BioAssay record AID 66011 submitted by ChEMBL: Antiviral activity (to reduce virus-induced cytopathogenicity) against Herpes simplex virus-1(KOS) in E6SM cell cultures.
ContextHerpes simplex virus type 2 (HSV-2) is one of the most common sexually transmitted infections in the United States. No prospective study has shown the
Antigen slides are well suited for IFA and IHC. Infected cells are mixed with uninfected cells so that each well of the slide has built in negative control ...
Gentaur molecular products has all kinds of products like :search , GenWay \ Herpes Simplex Virus-2 gD - \ 10-271-82180 for more molecular products just contact us
Thymidine Kinase from human Herpes simplex virus type 1 (HSV1-TK) in combination with specific substrate prodrug nucleotide analogue ganciclovir (GCV) has been widely used as suicidal therapeutic gene for cancer gene therapy. HSV1, and its mutant (HSV1-sr39TK) with improved substrate specificity, were used as reporter genes for PET-imaging of various biological functions in small animals, by combining with radiolabeled substrates such as 18F-FHBG and 124I-FIAU. 3H-Penciclovir (PCV) uptake assay is a method of choice used to determine the expression level of HSV1-TK in mammalian cells and tissues. HSV1-TK phosphorylate PCV and result in the formation of penciclovir monophosphate, and its subsequent phopsphorylation by cellular TK lead to the formation of penciclovir triphosphate, which is trapped selectively in cells express HSV-TK. 3H-Penciclovir enables the detection of penciclovir uptake of mammalian cells and tissues by radioactive procedures such as scintillation counting. Here we describe the
Herpes Simplex Virus Type 2 Herpes simplex virus type 2 is one of the two types of herpes viruses; it may also be called HSV-2. This virus is the cause of genital herpes wherein the infected person develops sores around his genitals or the skin surrounding his rectum or anal area. HSV-2 sores may also […]. ...
Herpes Simplex Virus Type 2 Herpes simplex virus type 2 is one of the two types of herpes viruses; it may also be called HSV-2. This virus is the cause of genital herpes wherein the infected person develops sores around his genitals or the skin surrounding his rectum or anal area. HSV-2 sores may also […]. ...
After DNA viruses enter the nucleus, they initiate a transcriptional cascade which is followed by replication. We investigated whether these processes take place at specific nuclear sites or, as suggested by the mode of entry, randomly throughout the nucleus. Three distinct nuclear domains, nuclear factor-1 sites, coiled bodies, and nuclear domain 10 (ND10), were used as markers to investigate the relative position of DNA virus replication sites. We found that all three nuclear domains had a very high spatial correlation with each other in uninfected cells. After adenoviral infection, nuclear factor 1 and coiled bodies were found associated with some viral replication domains. Simian virus 40 begins replication adjacent to ND10 but adenovirus 5 and herpes simplex type 1 modified ND10s before replication. Adenovirus E4orf 3 gene deletion mutants retain ND10 and begin replication at the peripheries of ND10. The same was found for the herpes simplex virus type 1 immediate early gene 1 mutants. That ...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
The virion host shutoff protein (Vhs) is a herpes simplex virus (HSV) protein involved in early shutoff of the host cell. It is a component of the infecting virion, located in the tegument region, that works by rapidly ...
Faculty advisor: Dr. Brian Lenzmeier. Human herpes simplex viruses cause serious damage to mucosal tissue in the mouth (HHV-1) and genitals (HHV-2). They can infect and establish latency in neurons and then reactivate and re-infect the original mucosal tissues. We are interested in determining host cell proteins that are used by Herpes viruses during the course of a neuronal infection. The assay we are using is the yeast two-hybrid where we co-express both the viral gE protein and a host cell protein inside of S. cerevisiae cells. If the two proteins interact, the yeast cell gains the ability to grow on agar plates lacking uracil, tryptophan, histidine and adenine. If the proteins do not interact, the cells will die on those same agar plates. We have used this assay to identify approximately two hundred proteins that potentially interact with the herpes virus gE protein. The neuronal proteins we have identified serve a variety of important functions, many of which are suggestive of a possible ...
Researchers at the University of California, San Diego School of Medicine have identified the evolutionary origins of human herpes simplex virus (HSV) -1 and -2, reporting that the former infected hominids before their evolutionary ...
Among his journalistic honors was a 1954 George Polk award, which is named after a CBS reporter who was killed while covering the Greek Civil War. Weller was a good friend of Polk and had served as his best man, said Jeff Donovan, a U.S. journalist who interviewed and befriended Weller about a decade ago while living in Rome.. ...
Herpes simplex virus 1 (HSV-1) induces a profound host shut-off during lytic infection. The virion host shut-off (vhs) protein plays a key role in this process by efficiently cleaving host and viral mRNAs. Furthermore, the onset of viral DNA replication is accompanied by a rapid decline in host transcriptional activity. To dissect relative contributions of both mechanisms and elucidate gene-specific host transcriptional responses throughout the first 8h of lytic HSV-1 infection, we employed RNA-seq of total, newly transcribed (4sU-labelled) and chromatin-associated RNA in wild-type (WT) and Δvhs infection of primary human fibroblasts. Following virus entry, vhs activity rapidly plateaued at an elimination rate of around 30% of cellular mRNAs per hour until 8h p.i. In parallel, host transcriptional activity dropped to 10-20%. While the combined effects of both phenomena dominated infection-induced changes in total RNA, extensive gene-specific transcriptional regulation was observable in ...
A viral tegument or tegument, more commonly known as a viral matrix, is a cluster of proteins that lines the space between the envelope and nucleocapsid of all herpesviruses. The tegument generally contains proteins that aid in viral DNA replication and evasion of the immune response, typically with inhibition of signalling in the immune system and activation of interferons. The tegument is usually[citation needed] released shortly after infection into the cytoplasm. These proteins are usually[citation needed] formed within the late phase of the viral infectious cycle, after viral genes have been replicated. Much information regarding viral teguments has been gathered from studying Herpes simplex virus. Viral teguments can be symmetrically arranged via structural and scaffolding protein or can also be asymmetrically arranged, depending on the virus.[citation needed] Teguments are rarely[citation needed] haphazardly placed and usually involve scaffolding proteins in their formation around the ...
Our recent efforts have been directed at the development of selective inhibitors of different classes of viruses, including adeno, pox, and herpesviruses [herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella-zoster (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV)], (+/-)RNA viruse …
Rates of herpes simplex virus type 2 (HSV-2) infection were much higher in teens with HIV or with a high risk of HIV than in the general population, ...
Virus-specific CD8+ T cells traffic to infected tissues to promote clearance of infection. We used herpes simplex virus type 2 (HSV-2) as a model system to investigate CD8+ T cell trafficking to the skin in humans. Using ...
Virus-specific CD8+ T cells traffic to infected tissues to promote clearance of infection. We used herpes simplex virus type 2 (HSV-2) as a model system to investigate CD8+ T cell trafficking to the skin in humans. Using ...
NV1020 is an oncolytic herpes virus initially developed by Medigene Inc. and licensed for development by Catherex Inc. in 2010 ... Human Gene Therapy. 23 (1): 91-7. doi:10.1089/hum.2011.141. PMID 21895536. "Amgen, Form 8-K, Current Report, Filing Date Jan 26 ... Mohr I, Gluzman Y (September 1996). "A herpesvirus genetic element which affects translation in the absence of the viral GADD34 ... Human Gene Therapy. 21 (9): 1119-28. doi:10.1089/hum.2010.020. PMC 3733135. PMID 20486770. Clinical trial number NCT00149396 ...
... (HHV-6) is the common collective name for human betaherpesvirus 6A (HHV-6A) and human betaherpesvirus 6B ( ... Media related to Human herpesvirus 6 at Wikimedia Commons Data related to Human herpesvirus 6 at Wikispecies (CS1 French- ... herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus ... Human herpesvirus 6 lives primarily on humans and, while variants of the virus can cause mild to fatal illnesses, can live ...
"Identification of New Herpesvirus Gene Homologs in the Human Genome". Genome Research. 12 (11): 1739-48. doi:10.1101/gr.334302 ... along with Ranid herpesvirus 2 and 3, are the only herpes viruses known to infect amphibians. With its lipid envelope, the ... Ranid herpesvirus 1 (RaHV-1), also known as the Lucké tumor herpesvirus (LTHV), is a double-stranded DNA virus within the order ... Ranid herpesvirus 1 is a double-stranded DNA virus approximately 217kbp in size. The genome is highly linear in structure and ...
Edelman DC (2005). "Human herpesvirus 8 - A novel human pathogen". Virology Journal. 2: 78. doi:10.1186/1743-422X-2-78. PMC ... Kaposi's sarcoma-associated herpesvirus (KSHV) is the ninth known human herpesvirus; its formal name according to the ... Mesri, Enrique A.; Cesarman, Ethel; Boshoff, Chris (October 2010). "Kaposi's sarcoma herpesvirus/ Human herpesvirus-8 (KSHV/ ... Schulz, T. F. (2000). "Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): Epidemiology and pathogenesis". The ...
"Pityriasis Rosea is Associated with Systemic Active Infection with Both Human Herpesvirus-7 and Human Herpesvirus-6". Journal ... Black, Jodi B.; Pellett, Philip E. (1999). "Human herpesvirus 7". Reviews in Medical Virology. 9 (4): 245-262. doi:10.1002/( ... Her dissertation was titled Human herpesvirus 6 strain Z29: Growth characteristics, virion specific protein identification and ... Black, Jodi Beth (1990). "Human herpesvirus 6 strain Z29: Growth characteristics, virion specific protein identification and ...
... human herpesvirus 6 and human betaherpesvirus 7). It is also related to other herpesviruses within the Alphaherpesvirinae ... It is thus longer than all other human herpesviruses and one of the longest genomes of all human viruses in general. It has the ... Humans and other primates serve as natural hosts. The 11 species in this genus include human betaherpesvirus 5 (HCMV, human ... Human CMV is the most studied of all cytomegaloviruses. MX2/MXB was identified as a restriction factor for herpesviruses, which ...
There is currently speculation that chromothripsis might be driven by viruses such as γ-herpes viruses which cause cancer, ... Thompson SL, Compton DA (2011). "Proliferation of aneuploid human cells is limited by a p53-dependent mechanism". The Journal ... Carcinogenesis Chromoplexy Kataegis Maher CA, Wilson RK (2012). "Chromothripsis and Human Disease: Piecing Together the ... Human Genetics. 71 (3): 187-191. doi:10.1007/BF00284570. PMID 4065890. S2CID 22597999. Tischkowitz MD, Hodgson SV (2003). " ...
"Human Herpesvirus 5 - an overview , ScienceDirect Topics". Sarma, Shohinee; Little, Derek; Ali, Tooba; Jones, Emily; Haider, ... Human betaherpesvirus 5, also called human cytomegalovirus (HCMV), is species of virus in the genus Cytomegalovirus, which in ... Human CMV causes cellular senescence, which could contribute to chronic inflammation (inflammaging). Human CMV is also linked ... Wikimedia Commons has media related to Human cytomegalovirus. Wikispecies has information related to Human betaherpesvirus 5. ...
There are nine known human herpesviruses. Of these, roseola has been linked to two: human herpesvirus 6 (HHV-6) and human ... It is caused by human herpesvirus 6 (HHV-6A, HHV-6B) or human herpesvirus 7 (HHV-7). Spread is usually through the saliva of ... Between the two types of human herpesvirus 6, HHV-6B has been detected much more frequently in hosts. HHV-6B has been shown to ... Roseola, also known as sixth disease, is an infectious disease caused by certain types of human herpes viruses. Most infections ...
Jordan MC, Jordan GW, Stevens JG, Miller G (June 1984). "Latent herpesviruses of humans". Annals of Internal Medicine. 100 (6 ... Herpesviruses, for example, can become latent after infecting the host, and after years they can activate again if the host is ... 5 (1): 33-36. doi:10.1016/S1369-5266(01)00219-9. hdl:11858/00-001M-0000-0012-36A6-C. ISSN 1369-5266. PMID 11788305. S2CID ... 156 (1-2): 183-194. Bibcode:2014APS..MARJ16002P. doi:10.1016/j.cell.2013.11.028. PMC 3956598. PMID 24361104. ...
Human herpes viruses, also known as HHVs, are part of a family of DNA viruses that cause several diseases in humans. One of the ... Human herpesviruses are all double stranded DNA viruses that enter the nucleus of the host cell. HHVs replicate in the nucleus ... Varicella zoster virus (VZV) is a member of the alpha subfamily of herpesviruses and is responsible for the human diseases of ... Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press. ISBN 9781139461641. Retrieved 2015-05 ...
"High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with ... HHV-8-associated MCD is known to be caused by infection with human herpesvirus-8. The HHV-8 virus is commonly found in healthy ... Human herpesvirus 8 associated multicentric Castleman disease (HHV-8-associated MCD) is a subtype of Castleman disease (also ... People with human herpesvirus 8 associated multicentric Castleman disease (HHV-8-associated MCD) have enlarged lymph nodes in ...
Human cytomegalovirus (HCMV), also known as Human herpesvirus 5 (HHV-5), Human herpesvirus 6A and 6B (HHV-6A and HHV-6B), which ... Both human herpesvirus 6B (HHV-6B) and human herpesvirus 7 (HHV-7), as well as other viruses, can cause a skin condition in ... Human herpesvirus 7 (HHV-7) Human cytomegalovirus (HCMV, HHV-5) "seems to have a large impact on immune parameters in later ... De Bolle, L.; Van Loon, J.; De Clercq, E.; Naesens, Lieve (2005). "Quantitative analysis of human herpesvirus 6 cell tropism". ...
November 2000). "Mucosal shedding of human herpesvirus 8 in men". N. Engl. J. Med. 343 (19): 1369-77. doi:10.1056/ ... Human Sexuality: An Encyclopedia states that "the inner third of the anal canal is less sensitive to touch than the outer two- ... Human sexuality portal LGBT portal Anal eroticism Ass to mouth Coprophilia Creampie (sexual act) Felching Gay bowel syndrome ... Most cases of anal cancer are related to infection with the human papilloma virus (HPV). Anal sex alone does not cause anal ...
November 2012). "Human herpesvirus 6 latent infection in patients with glioma". The Journal of Infectious Diseases. 206 (9): ... September 2009). "Detection of human herpesvirus-6 variants in pediatric brain tumors: association of viral antigen in low ... PPT refers to polyetherimide, PEG and trans-activator of transcription, and TRAIL is the human tumor necrosis factor-related ... Vilchez RA, Kozinetz CA, Arrington AS, Madden CR, Butel JS (June 2003). "Simian virus 40 in human cancers". The American ...
September 2018). Sandri-Goldin RM (ed.). "Human MxB Protein Is a Pan-herpesvirus Restriction Factor". Journal of Virology. 92 ( ... May 2018). "MxB is an interferon-induced restriction factor of human herpesviruses". Nature Communications. 9 (1): 1980. ... Interferon-induced GTP-binding protein Mx2 is a protein that in humans is encoded by the MX2 gene. The protein encoded by this ... October 2013). "Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection". Nature. 502 (7472): 559-62. ...
While the cause is not entirely clear, it is believed to be related to human herpesvirus 6 (HHV6) or human herpesvirus 7 (HHV7 ... "Evidence of human herpesvirus-6 and -7 reactivation in miscarrying women with pityriasis rosea". Journal of the American ... "Pityriasis rosea is not associated with human herpesvirus 7". Archives of Dermatology. 135 (9): 1070-2. doi:10.1001/archderm. ... Some believe it to be a reactivation of herpes viruses 6 and 7, which cause roseola in infants, though some investigations have ...
eds.). Human herpesviruses : biology, therapy, and immunoprophylaxis. Cambridge: Cambridge University Press. ISBN 978-0-521- ... Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis, Cambridge: Cambridge University Press, ISBN 978-0-521-82714-0, ... Humans are the only known species that the disease affects naturally. However, chickenpox has been caused in other primates, ... Belshe, Robert B. (1984). Textbook of human virology (2nd ed.). Littleton, MA: PSG. p. 829. ISBN 978-0-88416-458-6. Teri Shors ...
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press. ISBN 9780521827140. PMID 21348106 - ... One example is the herpes virus family, Herpesviridae, all of which establish latent infection. Herpes virus include chicken- ... This is also seen with infections of the human papilloma virus in which persistent infection may lead to cervical cancer as a ... These viruses have incorporated into the human genome in the distant past, and are now transmitted through reproduction. ...
Kaposi's sarcoma-associated herpesvirus and human T-lymphotropic virus. The most recently discovered human cancer virus is a ... Jordan MC, Jordan GW, Stevens JG, Miller G (June 1984). "Latent herpesviruses of humans". Annals of Internal Medicine. 100 (6 ... ISBN 978-0-7817-8215-9. Komaroff AL (December 2006). "Is human herpesvirus-6 a trigger for chronic fatigue syndrome?". Journal ... Infection by human T-lymphotropic virus can lead to tropical spastic paraparesis and adult T-cell leukaemia. Human ...
De Bolle L, Naesens L, De Clercq E (January 2005). "Update on human herpesvirus 6 biology, clinical features, and therapy". ... The first human virus to be identified was the yellow fever virus. In 1881, Carlos Finlay (1833-1915), a Cuban physician, first ... Epstein-Barr virus is important in the history of viruses for being the first virus shown to cause cancer in humans. The second ... Thorley-Lawson DA (August 2005). "EBV the prototypical human tumor virus-just how bad is it?". The Journal of Allergy and ...
... herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene. HFLB5 encodes a broadly ... v t e (Genes on human chromosome 11, All stub articles, Human chromosome 11 gene stubs). ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315-23. doi: ...
... human herpesvirus 6, human herpesvirus 7, and cytomegalovirus. Individuals with DRESS syndrome may exhibit sequential ... While these viral reactivations, particularly of human herpes virus 6, have been suggested to be an important factor in the ... Since the human population expresses some 13,000 different HLA serotypes while an individual expresses only a fraction of them ... Viruses known to do so include certain members of the Herpesviridae family of Herpes viruses viz., Epstein-Barr virus, ...
... formerly herpesvirus entry mediator C, HVEC) is a human protein of the immunoglobulin superfamily (IgSF), also considered a ... PVRL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... Cocchi F, Lopez M, Menotti L, Aoubala M, Dubreuil P, Campadelli-Fiume G (1999). "The V domain of herpesvirus Ig-like receptor ( ... v t e (Use dmy dates from June 2016, Genes on human chromosome 11, Wikipedia articles incorporating text from the United States ...
... human herpesvirus 6, human herpesvirus 7, and cytomegalovirus. Individuals suffering the DRESS syndrome may exhibit sequential ... While these viral reactivations, particularly of human herpes virus 6, have been suggested to be an important factor in the ... Rare case reports have associated the SJS/TEN spectrum of SCARs with reactivation of human herpesvirus 6; reactivation of ... Humans, it is estimated, express more than 10,000 different HLA class I proteins, 3,000 different HLA class II proteins, and ...
Kaposi Sarcoma is related to the Kaposi Sarcoma Herpes Virus (KSHV) or Human Herpes Virus (HHV-8) viral infection (3). ... Each human herpes virus may present differently within the oral cavity. They are more likely to affect immunocompromised ... glands are only present in their paws The majority of viral infections affecting the oral cavity are caused by the human Herpes Virus ... 6. Papillomas and warts/ verrucae They are caused by various strains of the Human Papilloma Virus (HPV) of which there are more ...
... and infection by Human herpesvirus 8 (HHV8 - also called KS-associated herpesvirus (KSHV)). Four sub-types are described: ... Ablashi DV, Chatlynne LG, Whitman JE, Cesarman E (July 2002). "Spectrum of Kaposi's sarcoma-associated herpesvirus, or human ... "Mucosal shedding of human herpesvirus 8 in men". The New England Journal of Medicine. 343 (19): 1369-77. doi:10.1056/ ... "Transmission of human herpesvirus 8 by blood transfusion". The New England Journal of Medicine. 355 (13): 1331-8. doi:10.1056/ ...
"The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk ... "Sexual transmission and the natural history of human herpesvirus 8 infection". N Engl J Med. 338 (14): 948-54. doi:10.1056/ ... Duesberg P (1989). "Human immunodeficiency virus and acquired immunodeficiency syndrome: correlation but not causation". Proc ... Duesberg rejects a role in cancer for numerous viruses, including leukemia viruses, Epstein-Barr virus, human papilloma virus, ...
2007). "Association of Human Herpesvirus-6B with Mesial Temporal Lobe Epilepsy". PLOS Med. 4 (5): e180. doi:10.1371/journal. ... 2003). "Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections". Neurology. 61 (10): 1405- ... In the mid-1980s, human herpesvirus 6 (HHV-6) was suggested as a possible causal link between febrile convulsions and mesial ... This was noted in human tissue in 1974 and in animal models in 1985. In TLE, the sprouting mossy fibres are larger than in the ...
Similar observations have been made in the herpesvirus family; for example, Epstein-Barr virus encodes an interleukin protein ... with high sequence identity to the human interleukin-10, suggesting a recent evolutionary origin. McFadden, Grant (June 2000 ... 144 (1-2): 233-49. doi:10.1016/j.virusres.2009.05.006. PMC 2779260. PMID 19464330. Fickenscher, H; Hör, S; Küpers, H; Knappe, A ... 3 (1): 36-50. doi:10.1038/nri980. PMID 12511874. S2CID 23531422. Lucas, A; McFadden, G (15 October 2004). "Secreted ...
A description of human papillomavirus (HPV) by electron microscopy was given in 1949, and HPV-DNA was identified in 1963. It ... Herpes viruses were also implicated in other malignant diseases, including Burkitt's lymphoma, Nasopharyngeal carcinoma, ... Human papillomavirus infection (HPV) causes more than 90% of cases; most women who have had HPV infections, however, do not ... Tiro JA, Meissner HI, Kobrin S, Chollette V (February 2007). "What do women in the U.S. know about human papillomavirus and ...
... and viruses of the herpesvirus family, such as human cytomegalovirus (HCMV) and Kaposi's sarcoma-associated herpesvirus (KSHV ... The superinduced human beta interferon messenger RNA was prepared by Tan's lab for Cetus corp. to clone the human beta ... Large amounts of human beta interferon were made by superinducing the beta interferon gene in human fibroblast cells. Cantell's ... Superinduction of the human beta interferon gene was also used by Israeli scientists to manufacture human beta interferon. ...
... such as oral hygiene and human herpesviruses. This condition can develop into necrotizing ulcerative periodontitis. This is an ... In humans, oral candidiasis is the most common form of candidiasis, by far the most common fungal infection of the mouth, and ... The global human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) pandemic has been an important factor in ... About 35-50% of humans possess C. albicans as part of their normal oral microbiota. With more sensitive detection techniques, ...
Following the eradication of the human-specific variola virus (smallpox), all human Orthopoxvirus infections are zoonoses. ... anthrax or Herpesvirus infections.) Severe edema and erythema may affect large areas of the body in cases of severe infection. ... human monkeypox most resembles mild smallpox. Human cowpox is a relatively severe localized infection. A survey of 54 cases ... However, human and prairie dog cases have occurred in the US due to contact with animals imported from Ghana, while in May of ...
KV BHU is an autonomous body working under aegis of Ministry of Human Resource and Development, Govt of India. The school has 4 ... known for Herpesvirus entry receptor, virus host interactions, Herpes simplex keratitis. Jayant Narlikar-Indian Astrophysicist, ... The school is affiliated to CBSE and has classes running from 1 to 12. The regional office of Varanasi Region of KVS is located ...
Unlike bacteria, both fungi and humans are eukaryotes. Thus, fungal and human cells are similar at the molecular level, making ... Herpes viruses, best known for causing cold sores and genital herpes, are usually treated with the nucleoside analogue ... they do not demonstrate unreasonable side effects to humans or the environment. Even once certain products are on the market, ... 3 (1): 21-23. doi:10.1016/S0269-915X(89)80010-2. Kingston W (June 2008). "Irish contributions to the origins of antibiotics". ...
"The Human Protein Atlas". www.proteinatlas.org. Archived from the original on 2017-05-01. Retrieved 2017-04-27. Hirokawa N, ... Some viruses (including retroviruses, herpesviruses, parvoviruses, and adenoviruses) that require access to the nucleus to ... while others such as humans use an analogous complex called HAUS) acts an additional means of microtubule nucleation in the ... "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human ...
Her studies of latent herpesviruses in the guinea pig led to the discovery of a lymphotropic herpesvirus and to the finding of ... In the late 1980s and early 1990s, she worked on antivirals for human immunodeficiency virus (HIV). Hsiung was the first to ... The isolation by Hsiung of a parainfluenza virus serologically related to SV5, the DA myxovirus, from human blood and the ... She worked extensively on the pathogenesis and treatment of herpesvirus infections, including genital herpes latency, in both ...
Normally the human eye responds to light rays from 390 to 760 nm. This can be extended to a range of 310 to 1,050 nm under ... There is some work relating to anti-herpes virus treatment. Research projects include work on central nervous system healing ... And even IR at wavelengths up to 1,050 nm from pulsed lasers can be seen by humans under certain conditions. A commonly used ... Humans at normal body temperature radiate chiefly at wavelengths around 10 μm (micrometers). Non-military uses include thermal ...
Chang CJ, Chao JC (April 2002). "Effect of human milk and epidermal growth factor on growth of human intestinal Caco-2 cells". ... Xie J, Pan H, Yoo S, Gao SJ (December 2005). "Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 ... Kim S, Yu SS, Lee IS, Ohno S, Yim J, Kim S, Kang HS (April 1999). "Human cytomegalovirus IE1 protein activates AP-1 through a ... Steiner C, Peters WH, Gallagher EP, Magee P, Rowland I, Pool-Zobel BL (March 2007). "Genistein protects human mammary ...
Numerous human pathogenic viruses in circulation are encased in lipid bilayers, and they infect their target cells by causing ... The following are some examples of enveloped viruses: DNA viruses Herpesviruses Poxviruses Hepadnaviruses Asfarviridae RNA ... One of the main parts of human pathogenic viruses is glycoprotein. They have been shown to play significant roles in immunity ... To create potentially protective vaccines for human pathogenic enveloped viruses for which there is currently no vaccine, it is ...
He is a member of the board of directors of the human vaccine program. He has published over 730 papers and edited several ... Richman conducted research on influenza virus, herpesviruses and hemorrhagic fever viruses before focusing on HIV in the 1980s ... ASM Press Washington DC; 1-1489, 2017. Anon (2003). "Dr. Douglas Richman wins VA's Middleton Award". J Investig Med. 51 (3): ... "Rapid evolution of the neutralizing antibody response to HIV type 1 infection". Proc Natl Acad Sci U S A. 100 (7): 4144-9. ...
Shin J, Lee JO, Choe JY, Bang SM, Lee JS (January 2017). "Human Herpesvirus 8-Unrelated Primary Effusion Lymphoma-Like Lymphoma ... Human herpes virus 8-negative primary effusion lymphoma-like lymphoma recurring as a tumor adjacent to the left atrium]". [ ... human herpesvirus 8-associated multicentric Castleman disease, and/or (especially in HIV-positive individuals) evidence of ... "Age and CD20 Expression Are Significant Prognostic Factors in Human Herpes Virus-8-negative Effusion-based Lymphoma". The ...
Human herpesvirus 8 (also known as Kaposi sarcoma-associated herpesvirus) is a virus associated with Kaposi sarcoma, a type of ... Human polyomavirus 2 (also known as JC virus) is known to cause progressive multifocal leukoencephalopathy (PML). ... one species of which can cause microsporidiosis in immunocompromised human hosts. Pneumocystis jirovecii (formerly known as ... 688-. ISBN 978-1-107-03891-2. Ledergerber B, Egger M, Erard V, Weber R, Hirschel B, Furrer H, et al. (December 1999). "AIDS- ...
By comparison, the number of base-pairs in a human genome is 3×109. A few of the main challenges of building a human connectome ... for example using Suid herpesvirus 1, SuHV1), and fusion of barcodes to represent a synaptic pair. This approach has the ... In their 2005 paper, "The Human Connectome, a structural description of the human brain", Sporns et al. wrote: To understand ... Sporns O, Tononi G, Kötter R (September 2005). "The human connectome: A structural description of the human brain". PLOS ...
On July 19, 2017, documents leaked online allege that Usher has been a carrier of the herpes virus since 2009 or 2010 and that ... The Freedom Awards honor individuals who work for justice, equality, philanthropy, civil and human rights and humanitarian ... alleging that he was positive for the herpes virus and did not tell them in advance. All three were represented by attorney ... 10 million lawsuit against Usher claiming that he exposed her to the herpes virus without her knowledge or consent, which is a ...
Infection with the herpes virus can occur after sexual contact with an infected carrier; this may lead to the development of ... "A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells". Human ... "Why Humans Lost Their Penis Bone". Science. 13 December 2016. Dixson, A. F. (2009). Sexual selection and the origins of human ... Wikimedia Commons has media related to Human penis. Wikiquote has quotations related to Human penis. Kinsey Institute on the ...
... human) Human Herpesvirus (1,2,3,4,5,6A,6B,7,8) Human Immunodeficiency Virus 1 (HIV-1) Human Immunodeficiency Virus 2 (HIV-2) ... Human Papillomavirus (HPV, 10, 16, 32, 5, 6B, 7, 9) Leishmania major Macaca mulatta (rhesus monkey) Meleagris gallopavo (turkey ... project-based approach to curation of human interaction data in manageable collections of high impact data. These themed ... Due to the overwhelming size of published scientific literature containing human (Homo sapiens) gene, protein, and chemical ...
Psychiatrists E. Fuller Torrey and R.H. Yolken have hypothesized that the latter, a common parasite in humans, contributes to ... Conejero-Goldberg C, Torrey EF, Yolken RH (March 2003). "Herpesviruses and Toxoplasma gondii in orbital frontal cortex of ... Flegr, J (2013). "Influence of latent Toxoplasma infection on human personality, physiology and morphology: Pros and cons of ... It has been speculated that CNVs underlie a significant proportion of normal human variation, including differences in ...
In non-humans, a few types of transmissible cancer have also been described, wherein the cancer spreads between animals by ... Kaposi's sarcoma herpesvirus (Kaposi's sarcoma and primary effusion lymphomas), hepatitis B and hepatitis C viruses ( ... The most common types of cancer differ, but the cancer burden seems at least as high in pets as in humans. Animals, typically ... Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity ...
November 2019). "Human papillomavirus and human telomerase RNA component gene in cervical cancer progression". Scientific ... Homologs of TERC can also be found in the Gallid herpes viruses. The core domain of TERC contains the RNA template from which ... Zhao JQ, Hoare SF, McFarlane R, Muir S, Parkinson EK, Black DM, Keith WN (March 1998). "Cloning and characterization of human ... Antal M, Boros E, Solymosy F, Kiss T (February 2002). "Analysis of the structure of human telomerase RNA in vivo". Nucleic ...
... (ephrin type-A receptor 2) is a protein that in humans is encoded by the EPHA2 gene. This gene belongs to the ... It is also the receptor by which Kaposi sarcoma-associated herpesvirus (KSHV) enters host cells; small molecule inhibitors of ... Sulman EP, Tang XX, Allen C, Biegel JA, Pleasure DE, Brodeur GM, Ikegaki N (April 1997). "ECK, a human EPH-related gene, maps ... Overview of all the structural information available in the PDB for UniProt: P29317 (Human Ephrin type-A receptor 2) at the ...
A virus causing respiratory disease in humans has been called human bocavirus due to its similarity to these viruses. Canine ... Carmichael, L. (2004). "Neonatal Viral Infections of Pups: Canine Herpesvirus and Minute Virus of Canines (Canine Parvovirus-1 ... McIntosh K (2006). "Human bocavirus: developing evidence for pathogenicity". J Infect Dis. 194 (9): 1197-9. doi:10.1086/508228 ... Carnivore bocaparvovirus 1, formerly Canine minute virus (or minute virus of canines; MVC) is a species of Bocaparvovirus of ...
CDC: Department of Human Services (9 September 1994). "Uveitis Associated with Rifabutin Therapy". 43(35);658: Morbidity and ... Infectious causes in order of global burden include: tuberculosis brucellosis herpesviruses (herpes zoster ophthalmicus - ... 41 (1): e11-e21. doi:10.1016/j.jfo.2017.11.003. PMID 29290458. Mayo Clinic 2021. Table 5-7 in: Mitchell RS, Kumar V, Abbas AK, ... 58 (1): 21-7. doi:10.4103/0301-4738.58469. PMC 2841370. PMID 20029143. Nian H, Liang D, Zuo A, Wei R, Shao H, Born WK, Kaplan ...
Lai Z, Ferry KV, Diamond MA, Wee KE, Kim YB, Ma J, Yang T, Benfield PA, Copeland RA, Auger KR (August 2001). "Human mdm2 ... Cadwell K, Coscoy L (April 2008). "The specificities of Kaposi's sarcoma-associated herpesvirus-encoded E3 ubiquitin ligases ... The human genome contains two genes that produce enzymes capable of activating ubiquitin: UBA1 and UBA6. Conjugation: E2 ... Humans possess 35 different E2 enzymes, whereas other eukaryotic organisms have between 16 and 35. They are characterised by ...
Human herpesvirus 6, the collective name for Human betaherpesvirus 6A and Human betaherpesvirus 6B Human betaherpesvirus 7 ... Herpes virus may refer to: Any member of the large family of DNA viruses known as Herpesviridae Human herpesviruses, nine types ... of herpesviruses that can cause diseases in humans Herpes simplex virus 1 and 2, responsible for herpes simplex infections ... Human gammaherpesvirus 8, or Kaposi's sarcoma-associated herpesvirus Herpes simplex, any infection caused by Herpes simplex ...
Pathogen - Human herpesvirus 8 (HHV-8) is the known causative agent in HHV-8-associated MCD, which has very similar symptoms ... Castleman disease describes a group of at least 3 distinct disorders-Unicentric Castleman disease (UCD), human herpesvirus 8 ... HHV-8-associated MCD is caused by uncontrolled infection with human herpesvirus 8 (HHV-8). In idiopathic multicentric Castleman ... 32 (1): 53-64. doi:10.1016/j.hoc.2017.09.005. PMID 29157619. Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, et ...
The expression of transcription activators by human herpesvirus-6 DNA is believed to be regulated by viral miRNA. miRNAs can ... The human homolog of miR-712 was found on the RN45s homolog gene, which maintains similar miRNAs to mice. MiR-205 of humans ... Wright MW, Bruford EA (January 2011). "Naming 'junk': human non-protein coding RNA (ncRNA) gene nomenclature". Human Genomics. ... "Small RNA deep sequencing identifies microRNAs and other small noncoding RNAs from human herpesvirus 6B". Journal of Virology. ...
Seroprevalence of Herpes simplex virus types 1 and 2 in Indian and Filipino migrant populations in Qatar: a cross-sectional ...
Dilnur P, Katano H, Wang ZH, Osakabe Y, Kudo M, Sata T, Classic type of Kaposis sarcoma and human herpesvirus 8 infection in ... Hladik W, Dollard SC, Mermin J, Fowlkes AL, Downing R, Amin MM, Transmission of human herpesvirus 8 by blood transfusion. N ... Hoffman LJ, Bunker CH, Pellett PE, Trump DL, Patrick AL, Dollard SC, Elevated seroprevalence of human herpesvirus 8 among men ... Huang LM, Huang SY, Chen MY, Chao MF, Lu CY, Tien HF, Geographical differences in human herpesvirus 8 seroepidemiology: a ...
find that the herpesvirus major transcription factor ICP4 regulates viral gene expression and replication through binding to ... G4s have been shown to form in the herpes simplex virus-1 (HSV-1) genome during its viral cycle. Here by cross-linking/pull- ... Our results indicate the existence of a well-defined G4-viral protein network that regulates the productive HSV-1 cycle. They ... ICP4 specific and direct binding and unfolding of parallel G4s, including those present in HSV-1 immediate early gene promoters ...
HSV (Human herpes virus 1 og 2) (=HHV1))-PCR, VZV(Human herpes virus 3)(=HHV3))PCR ... NPU12682 Csv-Human alphaherpesvirus 3(DNA); arb.k.(proc.) = ? NPU16113 Syst(spec.)-Herpes simplexvirus(DNA); arb.k.(proc.) = ? ... Herpes simplexvirus 1 og 2 samt Human herpesvirus 3 (Varicella zoster virus) (DNA) (R-nr. 238) Senest redigeret den 3. januar ... Urin 1 mL uden tilsætning (ved neonatal herpes). *EDTA-blod 3-6 mL eller serum (EDTA-blod foretrækkes til PCR analyser, da ...
Huang LM, Lee CY, Lin KH, Chuu WM, Lee PI, Chen RL, Human herpesvirus-6 associated with fatal haemophagocytic syndrome [letter] ... Yamanishi K, Okuno T, Shirake K, Takahashi M, Kondo T, Asano Y, Identification of human herpesvirus-6 as a causal agent for ... Human herpesvirus-6 (HHV-6)-associated hemophagocytic syndrome. Pediatr Hematol Oncol. 1996;13:451-6. DOIPubMedGoogle Scholar ... Clinical and serological features of human herpesvirus-6 infection in three adults. Lancet. 1988;2:817-9. DOIPubMedGoogle ...
Antiviral activity against Human herpesvirus 1 infected African green monkey Vero cells after 66 hr by viral plaque reduction ...
herpesvirus. Pádraig Duignan. California Sea Lion. Get Patient Updates Via Email Sign up ... has clear parallels to cervical cancer in humans and provides a helpful model for human cancer study. ... Herpesvirus Triggers Cervical Cancer Affecting Nearly 1 in 4 Adult Sea Lions, Parallels to Human Cancer Research March 30, 2021 ... The study, which was published in Animals, an open-access, peer-reviewed journal, concluded that genital herpesvirus is a ...
One human-to-human transmission has been identified (6). The incubation period in humans has been as short as 2 days but more ... B virus (Herpesvirus simiae) infection in humans: epidemiologic investigation of a cluster. Ann Intern Med 1990;112:833-9. ... Editorial Note: C. herpesvirus 1 (B virus) causes persistent latent infections in greater than or equal to 70% of captive adult ... Previously reported human infections usually have been attributed to macaque bites or scratches, injuries from needles used ...
Seroprevalence and Determinants of Human Herpes Virus 8 Infection in Adult Nigerians with and without HIV-1 Infection ... Seroprevalence and Determinants of Human Herpes Virus 8 Infection in Adult Nigerians with ... Full text: Available Index: AIM (Africa) Main subject: Humans / Seroepidemiologic Studies / Adult Type of study: Observational ... Full text: Available Index: AIM (Africa) Main subject: Humans / Seroepidemiologic Studies / Adult Type of study: Observational ...
... and human herpesvirus type 8-affected mother-infant pairs in Zambia. Cancer Epidemiology Biomarkers and Prevention, 17(9), 2238 ... and human herpesvirus type 8-affected mother-infant pairs in Zambia, Cancer Epidemiology Biomarkers and Prevention, vol. 17, ... and human herpesvirus type 8-affected mother-infant pairs in Zambia. Cancer Epidemiology Biomarkers and Prevention. 2008 Sep;17 ... and human herpesvirus type 8-affected mother-infant pairs in Zambia. In: Cancer Epidemiology Biomarkers and Prevention. 2008 ; ...
Dilnur P, Katano H, Wang ZH, Osakabe Y, Kudo M, Sata T, Classic type of Kaposis sarcoma and human herpesvirus 8 infection in ... Hladik W, Dollard SC, Mermin J, Fowlkes AL, Downing R, Amin MM, Transmission of human herpesvirus 8 by blood transfusion. N ... Hoffman LJ, Bunker CH, Pellett PE, Trump DL, Patrick AL, Dollard SC, Elevated seroprevalence of human herpesvirus 8 among men ... Huang LM, Huang SY, Chen MY, Chao MF, Lu CY, Tien HF, Geographical differences in human herpesvirus 8 seroepidemiology: a ...
Guidelines for Prevention of Herpesvirus Simiae (B Virus) Infection in Monkey Handlers ... Neutralizing antibodies in human sera to Herpesvirus simiae. Texas Rep Biol Med 1961;19:376-80.. POINT OF CONTACT FOR THIS ... Neither hyperimmune human B virus globulin nor vaccine against B virus is currently available.. Reported by The B Virus Working ... Herpesvirus simiae (B virus) is a member of the herpes group of viruses that is enzootic in rhesus (Macaca mulatta), cynomolgus ...
Human herpesvirus 6. Human parechovirus. Varicella zoster virus. Escherichia coli K1. Haemophilus influenza ... However, less than 1% of cases develop neuroinvasion, which presents in 1 of 3 forms: meningitis, encephalitis, or acute ... Table 1. Pathogens Tested in Meningitis Panel for Patient Case 2 Cytomegalovirus. ...
Kaposi sarcoma (human herpesvirus 8). *Adult T-cell leukemia/lymphoma (human T-lymphotropic virus-1) ... National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National ... Philadelphia, PA: Elsevier; 2021:chap 1.. National Cancer Institute website. Symptoms of cancer. www.cancer.gov/about-cancer/ ...
Herpesvirus 4, Human [‎1]‎. Herpesvirus 6, Human [‎1]‎. Herpesvirus Vaccines [‎1]‎. Heterozygote [‎4]‎. ...
Human herpesvirus 6 (HHV-6) is a human herpesvirus isolated from patients with various lymphoproliferative disorders and ... Prevalence of human herpesvirus 6 in Thai people and its correlation with human immunodeficiency virus type 1 infection. ... Prevalence of human herpesvirus 6 in Thai people and its correlation with human immunodeficiency virus type 1 infection. The ... 1-六月-1993. 引用: Sutthent R, Puthavathana P, Louisirirotchanakul S, Tunsupasawasdikul S, Wasi C, Thongcharoen P. ...
The study aimed to detect human herpes virus 6 (HHV-6) reactivation among allogeneic (allo) and autologous (auto) hematopoietic ... Human herpesvirus-6 in hematopoietic stem cell transplant recipients: a prospective cohort study in Egypt. ... Allogeneic; Autologous; HHV-6 reactivation; HSCT; Hematopoietic stem cell transplantation; Human herpesvirus 6 ... Human herpesvirus-6 in hematopoietic stem cell transplant recipients: a prospective cohort ...
Human herpesvirus 1. A herpes virus that causes cold sores and fever blisters in and around the mouth. Here is a depiction of a ... HHV-1 is also known as herpes simplex type (HSV 1) .. ... Medical Definition of HHV-1. *Medical Editor: Melissa Conrad ... typical fever blister caused by HHV-1:. In rare cases, as when the immune system is severely compromised, this virus can cause ...
Human / immunology * Herpesvirus 2, Human / immunology * Humans * Male * Middle Aged ... Niloufar Ameli 1 , Peter Bacchetti, Rhoda Ashley Morrow, Nancy A Hessol, Timothy Wilkin, Mary Young, Mardge Cohen, Howard ... Results: Reactivity to HSV-1 only and HSV-2 only was detected in 18% and 20% of HIV-infected, and in 28% and 18% of HIV- ... 1 Department of Medicine, Division of Infectious Diseases, University of California-San Francisco School of Medicine, San ...
Antiviral activity of the green marine alga Ulva fasciata on the replication of human metapneumovirus.. *G. Mendes, A. R. ... Inhibition of Herpesvirus Replication by Marine Algae Extracts. @article{Deig1974InhibitionOH, title={Inhibition of Herpesvirus ... The prophylactic but not therapeutic antiviral activity of these preparations seriously limits their potential use in human ... The prophylactic but not therapeutic antiviral activity of these preparations seriously limits their potential use in human ...
Herpesvirus-6, EBV, and the human immunodeficiency virus (HIV; which is not a member of the herpes family) have also been ... and human herpesvirus-6 collectively cause approximately 4% of cases of viral meningitis, with HSV-2 being the most common ... Enteroviruses enter the human host usually via the oral-fecal route, but can also spread through the respiratory route. ... Now a rare cause of meningitis, the virus is transmitted to humans by contact with rodents (eg, hamster, rats, mice) or their ...
Human herpesvirus (HHV) type 3. Intraoral herpes zoster closely resembles recurrent HHV-1 infection, but the lesions generally ... Breton G, Fillet AM, Katlama C, Bricaire F, Caumes E. Acyclovir-resistant herpes zoster in human immunodeficiency virus- ... However, the rules for common sites of occurrence of HHV-1 and HHV-3 often do not apply to patients who are immunocompromised. ... They found that controlled-release oxycodone was superior to placebo in the early period of pain (1-14 d). Gabapentin was not ...
Polyradiculoneuropathy Associated to Human Herpesvirus 2 in an HIV-1-Infected Patient (Elsberg Syndrome): Case Report and ... Concurrency, Sex Partner Risk, and High-Risk Human Papillomavirus Infection Among African American, Asian, and Hispanic Women. ... We describe bipolar anal and tonsilar tumoral lesions related to acyclovir-resistant Herpes simplex virus-2 in a human ... Among women participating in a human papillomavirus surveillance project, having concurrent sexual partnerships was associated ...
Categories: Herpesvirus 8, Human Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
humans to humans The etiologic agent of chickenpox. human herpes virus 3 ... Taenia infestation  humans are the definitive host Trichinellosis  humans eat larva of parasite Pinworm infestation  humans ... human granulocytic anaplasmosis Tularemia can be contracted by humans by all of the following methods except ________.. ... The cercariae penetrate human skin, A parasite of birds causes swimmers itch in humans,The intermediate host is an aquatic ...
Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with Me-ARA-EdU ... Find proteins for P0DTH5 (Human herpesvirus 1 (strain 17)). Explore P0DTH5 Go to UniProtKB: P0DTH5 ... Human alphaherpesvirus 1 strain 17. Mutation(s): 0 Gene Names: TK, TK (UL23), UL23. EC: ... 1-(2-deoxy-2-methyl-beta-D-arabinofuranosyl)-5-ethynylpyrimidine-2,4(1H,3H)-dione. C12 H14 N2 O5. HBALXYGFMJGYHQ-GTQWGBSQSA-N. ...
human herpesvirus. HIV-1. human immunodeficiency 1 virus. HRV. Human Rhinovirus. IQR. Inter-quartile range. L coding region. ... human rhinoviruses A and C (40%), respiratory syncytial virus (10%), and human herpesvirus 5 (10%) from nasopharyngeal swabs; ... This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. ... 1Weill Institute for Neurosciences, University of California, San Francisco, CA, USA ...
05163 Human cytomegalovirus infection. 3569 (IL6). 05167 Kaposi sarcoma-associated herpesvirus infection. 3569 (IL6). 05169 ... nt06164 Kaposi sarcoma-associated herpesvirus (KSHV). nt06165 Epstein-Barr virus (EBV). nt06167 Human cytomegalovirus (HCMV). ... nt06160 Human T-cell leukemia virus 1 (HTLV-1). nt06161 Human immunodeficiency virus type 1 (HIV-1). nt06162 Hepatitis B virus ... 05166 Human T-cell leukemia virus 1 infection. 3569 (IL6). 05161 Hepatitis B. 3569 (IL6). 05171 Coronavirus disease - COVID-19 ...
Human herpesvirus 1 (HHV-1) infection, although rare, has been associated with SSHL. Latent HHV-1 has been found in human ... Polymerase chain reaction was positive for human herpesvirus 1 obtained from the cerebral spinal fluid, which suggested the ... of the Eighth Cranial Nerve and Labyrinth on MR Imaging in Sudden Sensorineural Hearing Loss Associated with Human Herpesvirus ... Varicella-zoster virus, a member of the family of herpesviruses and which causes the Ramsay Hunt syndrome, is one example. ...
  • Here by cross-linking/pull-down assay we identified ICP4, the major HSV-1 transcription factor, as the protein that most efficiently interacts with viral G4s during infection. (nature.com)
  • In particular, herpes simplex virus-1 (HSV-1) infects ~70% of the adult population, establishing a latent neuronal infection which, upon stressful conditions, may be reactivated to a lytic symptomatic state. (nature.com)
  • There have been several reports of VAHS in children caused by Human herpesvirus 6 (HHV-6) infection. (cdc.gov)
  • On December 10, 1997, a 22-year-old female worker at a primate center died from Cercopithecine herpesvirus 1 (B virus) infection 42 days after biologic material (possibly fecal) from a rhesus macaque (Macaca mulatta) splashed into her right eye. (cdc.gov)
  • This investigation documented the hazard of ocular splashes and indicated that dendritic corneal lesions, such as herpetic skin vesicles, are not always present in B virus infection (1). (cdc.gov)
  • The seroprevalence of HHV8 infection was 62in HIV-1 positive patients and 25.9in HIV negative adults (p0.001). (bvsalud.org)
  • Objective: To determine the respective trends in mortality of Zambian mother-infant pairs based on maternal infection with HIV-1 and human herpesvirus type 8 (HHV-8). (nebraska.edu)
  • Seventeen additional cases of B virus infection in humans were described through 1973 (2)* and four cases, including the first known case of person-to-person transmission of the virus, occurred in Pensacola, Florida, in 1987 (5). (cdc.gov)
  • This extreme degree of morbidity and mortality has given the impression that B virus infection in humans nearly always results in severe or fatal disease. (cdc.gov)
  • The purpose of the working group was to supplement existing methods with specific guidelines intended to minimize transmission of B virus infection from macaque monkeys to humans. (cdc.gov)
  • As with herpes simplex virus I infection in humans, primary infection with B virus in macaques may result in gingivostomatitis with characteristic buccal mucosal lesions, but it probably occurs frequently without such signs. (cdc.gov)
  • Except for one instance of person-to-person transmission, however, all cases of B virus infection in humans have occurred in persons exposed to monkeys or monkey tissues. (cdc.gov)
  • IMSEAR at SEARO: Prevalence of human herpesvirus 6 in Thai people and its correlation with human immunodeficiency virus type 1 infection. (who.int)
  • Sutthent R, Puthavathana P, Louisirirotchanakul S, Tunsupasawasdikul S, Wasi C, Thongcharoen P. Prevalence of human herpesvirus 6 in Thai people and its correlation with human immunodeficiency virus type 1 infection. (who.int)
  • The prevalence of HHV-6 infection and its correlation as a cofactor in pathogenicity of HIV infection was investigated in serum samples from 365 healthy volunteers at various age groups, 50 persons at risk for HIV-1 infection, and 90 HIV-1 seropositive individuals. (who.int)
  • Prevalence of anti-HHV-6 IgG antibodies was not strikingly different among people at risk for HIV infection, asymptomatic HIV-1 infected cases, and aged-matched controls with low risk for HIV-1 infection. (who.int)
  • Identifying human herpesvirus 8 infection: performance characteristics of serological assays. (cdc.gov)
  • Latent class analysis of human herpesvirus 8 assay performance and infection prevalence in sub-Saharan Africa and Malta. (cdc.gov)
  • To determine the prevalence of infection with herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) among women with and at high risk for HIV infection, and to evaluate the effect of HAART on the recurrence of genital lesions. (nih.gov)
  • Human herpesvirus 1 (HHV-1) infection, although rare, has been associated with SSHL. (ajnr.org)
  • The serologic findings were consistent with reactivation of HHV-1 infection rather than primary infection, even though the patient denied having such a history. (ajnr.org)
  • High recombination rate in herpes simplex virus type 1 natural populations suggests significant co-infection. (ox.ac.uk)
  • Unlike the situation in developing countries, wild animals are the most important potential source of infection for humans and domestic animals in the US. (drugs.com)
  • SARS-CoV-2 infection even in its mild/asymptomatic form is a potent trigger for reactivation of latent herpesviruses (EBV, HHV6) and endogenous retroviruses (HERV-K), as detected by antibody fingerprints locally in the oral mucosa (saliva samples). (frontiersin.org)
  • The virus naturally infects macaque monkeys, resulting in disease that is similar to herpes simplex virus infection in humans. (cdc.gov)
  • Although B virus infection generally is asymptomatic or mild in macaques, it can be fatal in humans. (cdc.gov)
  • The present report updates previous recommendations for the prevention, evaluation, and treatment of B virus infection in humans and considers the role of newer antiviral agents in postexposure prophylaxis. (cdc.gov)
  • Yet, an understanding of the molecular mechanisms employed by herpesviruses to establish and maintain a latent state of infection, which is critical to the formation of life-long infections, are poorly understood. (umn.edu)
  • Unlike EBV and KSHV, y HV68 is capable of robust lytic infection in commonly used mouse and human tissue culture cell lines, facilitating my ability to conduct a large amount of essential research without the need for an animal host, 2. (umn.edu)
  • This showed us that the activation level of the NRF2 transcription factor can be a marker for temporary resistance to HSV-1 infection," says Franke. (mdc-berlin.de)
  • They found that a cell is more vulnerable to HSV-1 infection during some phases of the cell cycle than others. (mdc-berlin.de)
  • Treatment of Initial Infection of Herpes Genitalis: 200 mg (one 200 mg tablet or one teaspoonful of suspension [5 mL]) every 4 hours, 5 times daily for a total of 1 g daily for 10 days. (rxlist.com)
  • The herpes virus is not fatal in humans, but it causes chronic infection and genital ulcers that dramatically increase the risk of infection by HIV and other viruses. (harvard.edu)
  • In this study, we found that herpes simplex virus (HSV) infection induced extensive modification of tankyrase 1 but not tankyrase 2. (bris.ac.uk)
  • Following HSV-1 infection, tankyrase 1 was recruited to the nucleus. (bris.ac.uk)
  • In the early phase of infection, tankyrase 1 colocalized with ICP0 and thereafter localized within the HSV replication compartment, which was blocked in cells infected with the HSV-1 ICP0-null mutant R7910. (bris.ac.uk)
  • In the absence of infection, ICP0 interacted with tankyrase 1 and efficiently promoted its nuclear localization. (bris.ac.uk)
  • PRAGUE -- More than half of a group of patients with psoriasis tested positive for human herpes virus 8 (HHV-8), suggesting infection might play a role in the etiology of the disease, according to data reported here. (medpagetoday.com)
  • The movement of virions in PNS axons toward the cell body after primary infection or away from the neuronal cell body via PNS axons after replication implies that α-herpesviruses may encode gene products capable of regulating directional axonal transport. (rupress.org)
  • HIV disease is caused by infection with HIV-1 or HIV-2, which are retroviruses in the Retroviridae family, Lentivirus genus. (medscape.com)
  • CDC guidelines recommend testing for HIV infection with a US Food and Drug Administration (FDA)-approved antigen/antibody immunoassay that detects HIV-1 and HIV-2 antibodies and the HIV-1 p24 antigen, with supplemental testing after a reactive assay result to differentiate between HIV-1 and HIV-2 antibodies. (medscape.com)
  • If supplemental testing for HIV-1/HIV-2 antibodies shows nonreactive or indeterminant results (or if acute HIV infection or recent exposure is suspected or reported), an HIV-1 nucleic acid test is recommended to differentiate acute HIV-1 infection from a false-positive test result. (medscape.com)
  • 1 false-positive result per 100 people diagnosed with HIV infection). (medscape.com)
  • For example, psychological stress, a known inducer of glucocorticoid production, enhances the susceptibility of mice to herpes simplex virus type-1 (HSV-1) infection and results in the development of HSV-1 encephalitis (HSE). (umn.edu)
  • Our findings demonstrate that blockade of either the GR or the NMDA receptor enhances survival following HSV-1 infection in stressed mice to levels similar to non-stressed mice. (umn.edu)
  • MCC shares epidemiologic features with Kaposi sarcoma, a malignant tumor associated with human herpesvirus 8 infection ( 2 ). (cdc.gov)
  • Human Papillomavirus Infection Determines Prognosis in Cervical Cancer. (cdc.gov)
  • The place of the body where herpes caused by a virus type 1 or 2 appears for the first time (place of initial infection), depends on the virus type that causes it and on the way it uses to infect its host (person infected by the virus). (killherpesvirus.com)
  • Humans and viruses have co-evolved for millennia resulting in genetic polymorphisms that affect response to viral infection. (medrxiv.org)
  • Human herpesvirus 8 (HHV-8) is the infectious etiologic agent associated with Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. (cdc.gov)
  • 1 Department of Medicine, Division of Infectious Diseases, University of California-San Francisco School of Medicine, San Francisco, CA 94143, USA. (nih.gov)
  • 1) Infectious sources of cases of rabies in dogs in the United States in recent years were wildlife reservoirs or dogs that were translocated from localities where canine rabies virus variants still circulate. (drugs.com)
  • EBV, infectious mononucleosis (IM), glandular fever, Burkitt's lymphoma (BL), nasopharyngeal carcinoma (NPC) Footnote 1 Footnote 2 . (canada.ca)
  • Many complications, including autoimmune hemolytic anemia, splenic rupture, hemophagocytic lymphohistiocytosis, and neurological complications have also been associated with infectious mononucleosis Footnote 1 Footnote 5 . (canada.ca)
  • But the second hypothesis is that, because stress influences whether or not an animal is infectious for herpesvirus, whether or not they're actually shedding the virus, we hypothesized that animals in captivity, which is a pretty stressful environment their social system is disrupted and they're handled by humans pretty regularly that may make them shed more frequently than wild animals. (cdc.gov)
  • Poxviruses continue to cause serious diseases even after eradication of the historically deadly infectious human disease, smallpox. (researchgate.net)
  • deadly infectious human disease, smallpox. (researchgate.net)
  • Genomic changes in Kaposi Sarcoma-associated Herpesvirus and their clinical correlates. (cdc.gov)
  • northern Nigeria enrolled 71 HIV-1 positive adults without Kaposi's sarcoma and 85 apparently healthy HIV -negative adult volunteers of the general population . (bvsalud.org)
  • Kaposi's sarcoma-associated herpes virus (KSHV) is a human oncovirus. (cam.ac.uk)
  • Gammaherpesvirus human pathogens include Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV). (umn.edu)
  • HSV1 (Herpes Simplex Virus Type-1) is a member of the Herpes group of viruses, the Herpesviridiae, which includes the important human pathogens HSV2, CMV (Cytomegalovirus), Varicella zoster Virus, EBV (Epstein-Barr Virus), HSV6 and 7, and Kaposi's associated Herpes virus, HHV8 (Human Herpesvirus-8). (proteinlounge.com)
  • Details for: Epstein-Barr virus and Kaposi's sarcoma, herpesvirus/human herpesvirus. (who.int)
  • Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of primary effusion lymphoma (PEL) a rapidly progressing malignancy mostly arising in HIV-infected patients. (biotech2012.org)
  • Regional distribution of pooled human herpesvirus 8 (HHV-8) prevalence in A) the general population and B) immunocompromised patients, China. (cdc.gov)
  • Wild California sea lions have among the highest prevalence of a single type of cancer in any mammal, including humans. (marinemammalcenter.org)
  • Samantha Wisely] The full name of the virus is macacine herpesvirus 1 or herpes B, for short, and it's a virus that infects rhesus macaques monkeys. (cdc.gov)
  • The human herpesviruses constitute a large family of dsDNA viruses, which are the causative agents of a wide range of diseases, spanning from oral/genital blisters to cancer. (nature.com)
  • Herpesvirus simiae (B virus) is a member of the herpes group of viruses that is enzootic in rhesus (Macaca mulatta), cynomolgus (M. fascicularis) and other Asiatic monkeys of the genus Macaca. (cdc.gov)
  • Human immunodeficiency virus, type 1 (HIV-1) and type 2 (HIV-2) were selected as relevant viruses for plasma derived products. (drugs.com)
  • For the past several decades, the majority of naturally acquired, indigenous human rabies cases in the US have resulted from variants of rabies viruses associated with insectivorous bats. (drugs.com)
  • The results help us to better understand how these viruses evolved and found their way into humans," said Joel O. Wertheim, PhD, assistant research scientist at the UC San Diego AntiViral Research Center and lead author of the study. (ucsd.edu)
  • Understanding where our viruses come from will help guide us in preventing future viruses from making the jump into humans. (ucsd.edu)
  • Humans are the only primates we know of that have two herpes simplex viruses," said Wertheim. (ucsd.edu)
  • The researchers compared the HSV-1 and HSV-2 gene sequences to the family tree of simplex viruses from eight monkey and ape host species. (ucsd.edu)
  • The genetics of human and primate herpes viruses were examined to assess their similarity. (ucsd.edu)
  • The human herpes viruses (HHV) take part of a virus family - Herpesviridae- and these viruses have human as only host. (bvsalud.org)
  • This paper is a review about the human herpes viruses types, their treatments and emphasizes their oral manifestations. (bvsalud.org)
  • The lectures will cover human and animal-pathogenic viruses, bacteria and fungi as well as parasites (protozoa, helminths). (uni-luebeck.de)
  • The viruses that cause this disease belong to the subfamily alpha of the herpesvirus family . (killherpesvirus.com)
  • Herpes simplex virus type 1 and herpes simplex virus type 2 belong to the group of herpes simplex viruses, so that when we use this expression, we are referring to any of these two types of viruses. (killherpesvirus.com)
  • In this section I will talk about common characteristics to all the viruses that cause herpes (subfamily alpha: herpes simplex virus type 1, herpes simplex virus type 2 and varicella zoster virus), common characteristics to herpes simplex viruses and specific characteristics of the viruses of each type. (killherpesvirus.com)
  • Viruses need to enter human cells and use the "machinery" inside the human's cell to live and reproduce. (sspediatrics.com)
  • Our results indicate the existence of a well-defined G4-viral protein network that regulates the productive HSV-1 cycle. (nature.com)
  • Rabies Immune Globulin (Human) USP, Heat Treated, Imogam ® Rabies - HT, is a sterile solution of antirabies immunoglobulin (10-16% protein) for wound infiltration and intramuscular administration. (drugs.com)
  • It is demonstrated that macrophages are pp38 + because they are infected and not because they have phagocytosed MDV antigens, as assessed by confocal microscopy using antibodies recognizing MDV antigens of the three herpesvirus kinetic classes: infected cell protein 4 (ICP4, immediate early), pp38 (early) and glycoprotein B (gB, late). (microbiologyresearch.org)
  • Poly(ADP-ribosyl)ation of the nuclear mitotic apparatus (NuMA) protein by tankyrase 1 during mitosis is essential for sister telomere resolution and mitotic spindle pole formation. (bris.ac.uk)
  • When HIV-1 translates its genetic code into proteins, like coronavirus and unlike humans, it does not make one discrete protein at a time. (theamericansun.com)
  • We further validate 2 downstream candidates (oxidative stress-induced growth inhibitor 1) and (X-ray repair cross-complementing protein 5) and evaluate their functional relationship with PEL cell survival/proliferation and chemoresistance respectively. (biotech2012.org)
  • This is the first report of a previously healthy adult in whom Human herpesvirus 6 reactivation induced this syndrome with severe hemodynamic and respiratory distress. (cdc.gov)
  • Serum antibody tests for HHV-6 were positive (1:80 on day 7 and 1:280 on day 30 after admission), suggesting that this was a case of HHV-6 reactivation. (cdc.gov)
  • The study aimed to detect human herpes virus 6 ( HHV-6 ) reactivation among allogeneic (allo) and autologous (auto) hematopoietic stem cell transplant (HSCT) recipients and to correlate potentially attributed clinical manifestations to HHV-6 DNA plasma level. (bvsalud.org)
  • Reactivation of human herpesviruses 1-6 (HSV1, HSV2, VZV, EBV, CMV, HHV6), and human endogenous retrovirus K (HERV-K) was detected by anti-viral antibody fingerprints in saliva. (frontiersin.org)
  • Most primary infections occur between 1 and 5 years ‎while most reactivation infections occur after the age of 25 years. (who.int)
  • Researchers at the University of California, San Diego School of Medicine have mapped the transmission network of human immunodeficiency virus (HIV) in San Diego. (ucsd.edu)
  • Human immunodeficiency virus (HIV) is a blood-borne virus typically transmitted via sexual intercourse, shared intravenous drug paraphernalia, and during the birth process or via human milk (vertical transmission). (medscape.com)
  • Electron microscopy of human immunodeficiency virus (HIV)-1 virions. (medscape.com)
  • Antibody reactivity to latent and lytic antigens to human herpesvirus-8 in longitudinally followed homosexual men. (cdc.gov)
  • Latent HHV-1 has been found in human geniculate and vestibular ganglia (1) . (ajnr.org)
  • Quantitation of the latent HIV-1 reservoir from the sequence diversity in viral outgrowth assays. (cdc.gov)
  • Among women participating in a human papillomavirus surveillance project, having concurrent sexual partnerships was associated with high-risk human papillomavirus, however, the association varied by race/ethnicity. (lww.com)
  • Extended human papillomavirus genotyping to predict progression to high-grade cervical precancer: A prospective cohort study in the southeastern United States. (cdc.gov)
  • Human papillomavirus is a primary cause of cervical cancer and genital warts. (biomedcentral.com)
  • TNFSF14 can act as an immune adjuvant and enhance the immunogenicity of the human papillomavirus (HPV) DNA vaccine when the host is infected with HPV. (bvsalud.org)
  • A proposta desse trabalho foi avaliar a excreção oral dos herpesvirus humanos (HSV-1, HSV-2, EBV, CMV, VZV, HHV6, HHV7 e HHV8) e sua possível associação com o desenvolvimento e agravamento da mucosite oral, em pacientes diagnosticados com carcinoma epidermoide (CEC) de boca e orofaringe, submetidos à radioterapia associado à quimioterapia. (usp.br)
  • VAHS has been associated with Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus, and Herpes simplex virus (HSV), as well as with a variety of nonviral infections ( 1 ) . (cdc.gov)
  • The prophylactic but not therapeutic antiviral activity of these preparations seriously limits their potential use in human herpes simplex virus infections. (semanticscholar.org)
  • Herpesvirus infections are forever. (umn.edu)
  • Molecular biologists and bioinformaticians work closely together here, and this also applies to Dr. Emanuel Wyler and Dr. Vedran Franke, the two lead authors of a new study on HSV-1 infections. (mdc-berlin.de)
  • [ 34 ] Detection of co-infections with multiple herpesviruses can also be accomplished, with quantitative results enabling monitoring of virus load during antiviral therapy. (medscape.com)
  • Most EBV infections are acquired during childhood and are asymptomatic Footnote 1 Footnote 5 . (canada.ca)
  • 3-5 A study in Japan suggested rotavirus is the third leading pathogen of infections that proceed acute encephalopathy nationally after influenza virus and human herpesvirus-6. (who.int)
  • Changes in leukocyte count (solid circles), platelet count (solid squares), and serum antibodies tests for Human herpesvirus 6 (HHV-6), Herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) after admission. (cdc.gov)
  • Serum antibody tests for CMV and HSV were negative, but a serum antibody test for EBV was positive (1:640) on day 2 after admission. (cdc.gov)
  • In patients with ME/CFS, antibody responses were significantly stronger, in particular EBV-encoded nuclear antigen-1 (EBNA1) IgG were elevated in patients with ME/CFS, but not in HDs. (frontiersin.org)
  • Identification of the neoplastically transformed cells in Marek's disease herpesvirus-induced lymphomas: recognition by the monoclonal antibody AV37. (microbiologyresearch.org)
  • Detection of Rat IgG Control by Flow Cytometry J774A.1 mouse reticulum cell sarcoma macrophage cell line was stained with Rat Anti-Mouse GM-CSF Ra APC-conjugated Monoclonal Antibody (Catalog # FAB6130A , filled histogram) or Rat IgG APC-conjugated Isotype Control Antibody (Catalog # IC006A, open histogram). (rndsystems.com)
  • Signals in human leukocyte antigen (HLA) class II region dominated the landscape of viral antibody response, with 40 independent loci and 14 independent classical alleles, 7 of which exhibited pleiotropic effects across viral families. (medrxiv.org)
  • Immunofluorescence micrograph of peripheral blood mononuclear cells infected with Human herpesvirus 6B isolated on day 5 after admission. (cdc.gov)
  • Antiviral activity of the green marine alga Ulva fasciata on the replication of human metapneumovirus. (semanticscholar.org)
  • Effects of interferon-beta therapy on elements in the antiviral immune response towards the human herpesviruses EBV, HSV, and VZV, and to the human endogenous retroviruses HERV-H and HERV-W in multiple sclerosis. (au.dk)
  • Varicella-zoster virus, a member of the family of herpesviruses and which causes the Ramsay Hunt syndrome, is one example. (ajnr.org)
  • The first type of virus is named herpes simplex virus type 1 (HSV-1), the second type is called herpes simplex virus type 2 (HSV-2) and the third type is known as varicella zoster virus. (killherpesvirus.com)
  • Periodontal disease and detection of human herpesviruses in saliva and gingival crevicular fluid of chronic kidney disease patients. (bvs.br)
  • Recommendations for prevention and therapy of person's exposed to B virus (Cercopithecine herpesvirus 1). (cdc.gov)
  • B virus (Cercopithecine herpesvirus 1) is a zoonotic agent that can cause fatal encephalomyelitis in humans. (cdc.gov)
  • B and T lymphocyte attenuator (BTLA) is an Ig superfamily coinhibitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. (biolegend.com)
  • Herpes simplex virus glycoprotein D bound to the human receptor HveA. (proteinlounge.com)
  • Blockade of the NMDA receptor, however, diminished HSV-1-induced increases in class I expression by CD45 hi cells, suggesting that blockade of the NMDA receptor may limit CNS inflammation. (umn.edu)
  • Tumor necrosis factor superfamily 14 (TNFSF14) (LIGHT) is an interesting costimulatory molecule associated with T lymphocyte activation, and it mainly exerts its biological effects by binding to its receptors herpesvirus invasion mediator (HVEM) and lymphotoxin-ß receptor. (bvsalud.org)
  • The study findings suggest an adverse interaction between HHV8 and HIV-1 . (bvsalud.org)
  • Sensitivity and specificity of the orf73 ELISA have not been established, although the widely used indirect immunofluorescence assay for LANA antibodies has reasonable but perhaps more variable sensitivity (80-100%) and specificity (57-100%) (1;3). (cdc.gov)
  • Serum antibodies to HSV-1 and HSV-2 at baseline and self-reported history of genital herpes, reports of recent genital sores and presence of genital ulcers on examination, and use of HAART regimen at each study visit were analyzed. (nih.gov)
  • To summarize the seroprevalence of human herpesvirus 8 (HHV-8) in mainland China, we conducted a systematic review and meta-analysis based on available literature. (cdc.gov)
  • Worldwide seroprevalence of HHV-8 varies: generally low to moderate for populations in Western countries and Asia ( 1 - 4 ) but as high as 50% for the general population in sub-Saharan Africa and higher for HIV-positive populations ( 5 - 7 ). (cdc.gov)
  • abstract = "Tankyrase 1 is a poly(ADP-ribose) polymerase (PARP) which localizes to multiple subcellular sites, including telomeres and mitotic centrosomes. (bris.ac.uk)
  • VZV is classified as one of the human alpha-herpesviruses and is a linear, double-stranded DNA virus with an icosahedral capsid and an envelope with glycoprotein spikes. (medscape.com)
  • Sarah Gregory] Your study is about invasive monkeys in Florida that have herpesvirus 1. (cdc.gov)
  • And what's odd about this is that humans come into contact with wild macaques regularly. (cdc.gov)
  • Polymerase chain reaction was positive for HHV-1 in the cerebrospinal fluid. (ajnr.org)
  • Additional reported applications (for the relevant formats) include: inhibition of T cell proliferation and cytokine production 1 . (biolegend.com)
  • Table1)1) is involved in proliferation inhibition of acute myeloid leukemia mediated by Maesopsin 4-O-beta-D-glucoside a natural compound isolated from the leaves of Artocarpus tonkinensis) [21]. (biotech2012.org)
  • Significance of Herpesvirus Entry Mediator Expression in Human Colorectal Liver Metastasis. (nih.gov)
  • Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active Multiple Sclerosis. (au.dk)
  • Again Study 1 was the only one of the three to find a relationship between sex and ACE2 expression. (theamericansun.com)
  • 2005). Small Nuclear RNAs Encoded by Herpesvirus saimiri Upregulate the Expression of Genes Linked to T Cell Activation in Virally Transformed T Cells. (cookandersenlaboratory.com)
  • G4s have been shown to form in the herpes simplex virus-1 (HSV-1) genome during its viral cycle. (nature.com)
  • HSV-1 is the major cause of blindness and viral encephalitis worldwide. (nature.com)
  • The water extract from the red marine alga Polysiphonia denudata (Dillwyn) Kütz selectively inhibited the reproduction of herpes virus type 1 and type 2 in cell cultures as shown by the reduction of virusinduced cytopathic effect and viral infectivity. (semanticscholar.org)
  • Polymerase chain reaction was positive for human herpesvirus 1 obtained from the cerebral spinal fluid, which suggested the diagnosis of viral neuritis. (ajnr.org)
  • This approach allowed them to determine when HSV-1 and HSV-2 were introduced into humans with far more precision than standard models that do not account for natural selection over the course of viral evolution. (ucsd.edu)
  • Comparing virus gene sequences gives us insight into viral pathogens that have been infecting us since before we were humans," said Wertheim. (ucsd.edu)
  • Não, pois não há suporte na literatura científica para indicação de colutórios (bochechos) à base de peróxido de hidrogênio (água oxigenada) para controle da infecção viral como um todo, e do SARS COV2, em particular, associado com a falta de substantividade desses produtos, portanto, sua indicação em odontologia e protocolos de atendimento durante a COVID-19 pandemia devem ser revisadas (1) . (bvs.br)
  • The most common viral pathogens recovered from hospitalized patients admitted with CAP include human rhinovirus and influenza . (medscape.com)
  • The cancer, known as sea lion urogenital carcinoma, has clear parallels to cervical cancer in humans and provides a helpful model for human cancer study. (marinemammalcenter.org)
  • Immune responses to human endogenous retroviruses are associated with disease activity in multiple sclerosis. (au.dk)
  • plasmablastic lymphoma or any CD20- lymphoma, such as anaplastic lymphoma kinase-positive large B-cell lymphoma, human herpesvirus type 8-positive DLBCL, or primary effusion lymphoma. (who.int)
  • Epstein-Barr Virus in Burkitt Lymphoma in Africa Reveals a Limited Set of Whole Genome and LMP-1 Sequence Patterns: Analysis of Archival Datasets and Field Samples From Uganda, Tanzania, and Kenya. (cdc.gov)
  • However, less than 1% of cases develop neuroinvasion, which presents in 1 of 3 forms: meningitis, encephalitis, or acute flaccid paralysis. (medscape.com)
  • Serologic measurements in the acute phase demonstrated no marked elevation of immunoglobulin (Ig) M against HHV-1 with an IgG level of 4.46 mg/dL (normal range, 0-0.79 mg/dL), while convalescent serologic measurements 6 weeks later showed an IgG level of 3.28 mg/dL. (ajnr.org)
  • y HV68 is a powerful research tool to investigate gammaherpesvirus biology for several reasons: 1. (umn.edu)
  • 1 Some patients need fluid therapy at the hospital for severe dehydration. (who.int)
  • Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase. (ox.ac.uk)
  • Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine. (ox.ac.uk)
  • About 80 percent of the global population carries the herpes simplex virus type 1 (HSV-1). (mdc-berlin.de)
  • A new type of treatment has been found to protect mice against a nasty strain of herpes virus common in humans. (harvard.edu)
  • Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1. (proteinlounge.com)
  • Herpes simplex virus type 1 affects initially, with more frequency, the parts of the body that are above the waist, while herpes simplex virus type 2 affects mostly the parts below the waist. (killherpesvirus.com)
  • In a same way, it can happen that somebody with labial herpes, caused by herpes simplex virus type 1, contaminates his or her sexual partners causing them genital herpes. (killherpesvirus.com)
  • Although the identification of the type of virus (HSV-1 or HSV-2) is not important to name the illness that it causes, it is important in the selection of the cure for herpes. (killherpesvirus.com)
  • In AIDS patients or other immunosuppressed patients, many EBV-associated diseases may occur, such as oral hairy leukoplasia, interstitial lymphocytic pneumonia, B-cell or T-cell lymphomas and mesenchymal lymphomas (for e.g. leiomyosarcoma) Footnote 1 Footnote 2 Footnote 3 Footnote 4 Footnote 7 . (canada.ca)
  • It accounts for 40 and 50% of childhood non-Hodgkin's lymphomas (NHLs) and 1-2% of adult lymphomas in Western Europe and the United States Footnote 8 . (canada.ca)
  • Although it is commonly believed that transmission to humans occurs by exposure to contaminated monkey saliva through bites or scratches, such exposure has not been consistently documented. (cdc.gov)
  • B virus-related disease is characterized by a variety of symptoms, which generally occur within 1 month of exposure. (cdc.gov)
  • Rabies Immune Globulin (Human) Heat Treated, Imogam Rabies - HT, in conjunction with the standard series of Rabies Vaccine vaccinations, is indicated for individuals suspected of exposure to rabies, particularly severe exposure, with one exception: persons who have been previously immunized with Rabies Vaccine. (drugs.com)
  • Epstein-Barr virus belongs to genus lymphocryptovirus of the subfamily Gammaherpesvirinae in the Herpesviridae family Footnote 1 Footnote 2 . (canada.ca)
  • Researchers at the University of California, San Diego School of Medicine have identified the evolutionary origins of human herpes simplex virus (HSV) -1 and -2, reporting that the former infected hominids before their evolutionary split from chimpanzees 6 million years ago while the latter jumped from ancient chimpanzees to ancestors of modern humans - Homo erectus - approximately 1.6 million years ago. (ucsd.edu)
  • After more than three decades of research, scientists have proven that the cancer affecting up to one in four adult California sea lions that received a necropsy, or animal autopsy, at The Marine Mammal Center in Sausalito, CA, is caused by a sexually transmitted herpesvirus. (marinemammalcenter.org)
  • The Marine Mammal Center is the world's largest marine mammal hospital and has been on the forefront of researching and understanding cancer in California sea lions and its connection to both ocean and human health. (marinemammalcenter.org)
  • HVEM/HIF-1α promoted proliferation and inhibited apoptosis of ovarian cancer cells under hypoxic microenvironment conditions. (nih.gov)
  • We also identified two novel human rhinovirus C species. (biorxiv.org)
  • Picorna - 1 subtype called rhinovirus has at least 100 common cold strains. (sspediatrics.com)
  • 2004). The Herpesvirus saimiri Small Nuclear RNAs Recruit AU-Rich Element-Binding Proteins but Do Not Alter Host AU-Rich Element-Containing mRNA Levels in Virally Transformed T Cells. (cookandersenlaboratory.com)
  • Patterns of Eurasian HSV-1 molecular diversity and inferences of human migrations. (ox.ac.uk)
  • Molecular and Cellular Endocrinology 373(1-2):51-60. (cookandersenlaboratory.com)
  • The study, which was published in Animals , an open-access, peer-reviewed journal, concluded that genital herpesvirus is a driving factor in the development of sea lion urogenital carcinoma . (marinemammalcenter.org)
  • Resveratrol also significantly reduced the replication of monkeypox virus, a zoonotic virus that is endemic in Western and Central Africa and causes human mortality. (researchgate.net)
  • It consists of a double-stranded 172 Kb DNA genome, enclosed within an icosahedral capsid, surrounded by a phospholipid rich envelope Footnote 1 Footnote 3 . (canada.ca)
  • The book provides an overview of insects, mites and ticks that directly cause diseases of humans and domestic animals, and that transmit microbes causing disease. (e-booksdirectory.com)
  • Many benign and malignant diseases, however, have been associated with Epstein- Barr virus in both immunocompetent and immunocompromised patients Footnote 1 Footnote 2 Footnote 3 Footnote 4 Footnote 5 Footnote 6 Footnote 7 Footnote 8 Footnote 9 . (canada.ca)
  • I would not bring a feral cat inside to mix with existing cats until you are sure she/he is negative for the regular diseases such as FIV, FeLV, FIP, cat colds (herpesvirus or calicivirus), Panleukopenia. (pictures-of-cats.org)
  • In inflammatory diseases, reversible (for 6-8 hours) inhibits excessive synthesis of tumor necrosis factor, interleukin-1 and other pro-inflammatory cytokines, active forms of oxygen by hyperactivated macrophages, determining the degree of inflammatory reactions, their cyclicity, and the severity of intoxication. (lekarstwo.ru)
  • Football's characteristic violence, its sanctioned mayhem and head trauma, combine in this image with the very human story of two men in their professional primes, both of whom will eventually develop degenerative brain diseases, their lives twined like a double helix, part of football's DNA. (harvardreview.org)
  • ICP4 specific and direct binding and unfolding of parallel G4s, including those present in HSV-1 immediate early gene promoters, induced transcription in vitro and in infected cells. (nature.com)
  • Maintenance of Marek's disease herpesvirus latency in vitro by a factor found in conditioned medium. (microbiologyresearch.org)
  • Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma. (nih.gov)