The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
The study of medicines derived from botanical sources.
Use of plants or herbs to treat diseases or to alleviate pain.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
The pharmacological result, either desirable or undesirable, of drugs interacting with components of the diet. (From Stedman, 25th ed)
Dynamic and kinetic mechanisms of exogenous chemical and DRUG LIBERATION; ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and DRUG TOXICITY as a function of dosage, and rate of METABOLISM. LADMER, ADME and ADMET are abbreviations for liberation, absorption, distribution, metabolism, elimination, and toxicology.
A plant species of the genus CITRUS, family RUTACEAE that produces the familiar grapefruit. There is evidence that grapefruit inhibits CYTOCHROME P-450 CYP3A4, resulting in delayed metabolism and higher blood levels of a variety of drugs.
Material prepared from plants.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.
Books in the field of medicine intended primarily for consultation.
The action of a drug in promoting or enhancing the effectiveness of another drug.
A macrolide antibiotic that is similar to ERYTHROMYCIN.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
The dried seeds, bark, root, stems, buds, leaves, or fruit of aromatic plants used to season food.
Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431)
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Therapy with two or more separate preparations given for a combined effect.
Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy.
An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Dried rhizome and roots of Piper methysticum, a shrub native to Oceania and known for its anti-anxiety and sedative properties. Heavy usage results in some adverse effects. It contains ALKALOIDS; LACTONES; kawain, methysticin, mucilage, STARCH, and yangonin. Kava is also the name of the pungent beverage prepared from the plant's roots.
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
System of herbal medicine practiced in Japan by both herbalists and practitioners of modern medicine. Kampo originated in China and is based on Chinese herbal medicine (MEDICINE, CHINESE TRADITIONAL).
Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.
The relationship between the dose of an administered drug and the response of the organism to the drug.
17 beta-Hydroxy-4-androsten-3-ones. Testosterone derivatives formed by the substitution of one or more hydroxyl groups in any position.
A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Drugs intended for DENTISTRY.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Coumarin derivative that acts as a long acting oral anticoagulant.
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
A plant order of the subclass Dilleniidae, class Magnoliopsida. It includes 18 families, approximately 175 genera, and 3,400 species. Its members are mostly tropical trees and shrubs.
A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.
A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.
An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Services providing pharmaceutic and therapeutic drug information and consultation.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
The giving of drugs, chemicals, or other substances by mouth.
A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Inhibitors of HIV PROTEASE, an enzyme required for production of proteins needed for viral assembly.
A serotonin uptake inhibitor that is effective in the treatment of depression.
Agents that prevent clotting.
The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically.
The only specie of the genus Ginkgo, family Ginkgoacea. It is the source of extracts of medicinal interest, especially Egb 761. Ginkgo may refer to the genus or species.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
The plant Silybum marianum in the family ASTERACEAE containing the bioflavonoid complex SILYMARIN. For centuries this has been used traditionally to treat liver disease. Silybum marianum (L.) Gaertn. = Carduus marianus L.
Drugs used to prevent SEIZURES or reduce their severity.
Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)
A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.
The self administration of medication not prescribed by a physician or in a manner not directed by a physician.
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.
Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
Directions written for the obtaining and use of DRUGS.
Proteins involved in the transport of organic anions. They play an important role in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
The management and maintenance of colonies of honeybees.
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
Medicines that can be sold legally without a DRUG PRESCRIPTION.
OXAZINES with a fused BENZENE ring.
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
The removing of alkyl groups from a compound. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Laws concerned with manufacturing, dispensing, and marketing of drugs.
Liquids that are suitable for drinking. (From Merriam Webster Collegiate Dictionary, 10th ed)
The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.
The quality of not being miscible with another given substance without a chemical change. One drug is not of suitable composition to be combined or mixed with another agent or substance. The incompatibility usually results in an undesirable reaction, including chemical alteration or destruction. (Dorland, 27th ed; Stedman, 25th ed)
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Errors in prescribing, dispensing, or administering medication with the result that the patient fails to receive the correct drug or the indicated proper drug dosage.
A tricyclic antidepressant with actions similar to AMITRIPTYLINE.
A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC
Authoritative treatises on drugs and preparations, their description, formulation, analytic composition, physical constants, main chemical properties used in identification, standards for strength, purity, and dosage, chemical tests for determining identity and purity, etc. They are usually published under governmental jurisdiction (e.g., USP, the United States Pharmacopoeia; BP, British Pharmacopoeia; P. Helv., the Swiss Pharmacopoeia). They differ from FORMULARIES in that they are far more complete: formularies tend to be mere listings of formulas and prescriptions.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.
A macrolide antibiotic that has a wide antimicrobial spectrum and is particularly effective in respiratory and genital infections.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
A calcium channel blocker that is a class IV anti-arrhythmia agent.
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
Painful sensation in the muscles.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
A group of compounds that contain the structure SO2NH2.
A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.
A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
A plant genus of the family Ephedraceae, order Ephedrales, class Gnetopsida, division Gnetophyta.
Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (PHYSICAL THERAPY MODALITIES; DIET; ACUPUNCTURE) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Inhibitors of HIV INTEGRASE, an enzyme required for integration of viral DNA into cellular DNA.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)
A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Compounds that specifically inhibit the reuptake of serotonin in the brain.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
The science concerned with the benefit and risk of drugs used in populations and the analysis of the outcomes of drug therapies. Pharmacoepidemiologic data come from both clinical trials and epidemiological studies with emphasis on methods for the detection and evaluation of drug-related adverse effects, assessment of risk vs benefit ratios in drug therapy, patterns of drug utilization, the cost-effectiveness of specific drugs, methodology of postmarketing surveillance, and the relation between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines. (Pharmacoepidemiol Drug Saf 1992;1(1); J Pharmacoepidemiol 1990;1(1))
Cell surface proteins that bind biogenic amines with high affinity and regulate intracellular signals which influence the behavior of cells. Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these.
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Adjunctive computer programs in providing drug treatment to patients.
A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
Substances obtained from various species of microorganisms that are, alone or in combination with other agents, of use in treating various forms of tuberculosis; most of these agents are merely bacteriostatic, induce resistance in the organisms, and may be toxic.
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.
Educational programs designed to inform graduate pharmacists of recent advances in their particular field.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Six-membered heterocycles containing an oxygen and a nitrogen.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
The rate dynamics in chemical or physical systems.
Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
Elements of limited time intervals, contributing to particular results or situations.
A subclass of ORGANIC ANION TRANSPORTERS that do not rely directly or indirectly upon sodium ion gradients for the transport of organic ions.
The traditional Hindu system of medicine which is based on customs, beliefs, and practices of the Hindu culture. Ayurveda means "the science of Life": veda - science, ayur - life.
Substances that reduce the growth or reproduction of BACTERIA.
A plant genus of the family ASTERACEAE with strong-smelling foliage. It is a source of SANTONIN and other cytotoxic TERPENES.
A semisynthetic derivative of CODEINE.
A plant species of the Salvia genus known as a spice and medicinal plant.
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Compounds with a BENZENE fused to IMIDAZOLES.
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.
Systems of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (SPIRITUAL THERAPIES); PHYTOTHERAPY; and other treatments which may not be explained by modern medicine.
Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Drugs that cannot be sold legally without a prescription.
A polyspecific transporter for organic cations found primarily in the kidney. It mediates the coupled exchange of alpha-ketoglutarate with organic ions such as P-AMINOHIPPURIC ACID.
Six-carbon alicyclic hydrocarbons.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.
Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.
Persons with no known significant health problems who are recruited to participate in research to test a new drug, device, or intervention as controls for a patient group. (from, accessed 2/14/2013)
A type of MICROCOMPUTER, sometimes called a personal digital assistant, that is very small and portable and fitting in a hand. They are convenient to use in clinical and other field situations for quick data management. They usually require docking with MICROCOMPUTERS for updates.

Herbal remedies: adverse effects and drug interactions. (1/156)

A growing number of Americans are using herbal products for preventive and therapeutic purposes. The manufacturers of these products are not required to submit proof of safety and efficacy to the U.S. Food and Drug Administration before marketing. For this reason, the adverse effects and drug interactions associated with herbal remedies are largely unknown. Ginkgo biloba extract, advertised as improving cognitive functioning, has been reported to cause spontaneous bleeding, and it may interact with anticoagulants and antiplatelet agents. St. John's wort, promoted as a treatment for depression, may have monoamine oxidase-inhibiting effects or may cause increased levels of serotonin, dopamine and norepinephrine. Although St. John's wort probably does not interact with foods that contain tyramine, it should not be used with prescription antidepressants. Ephedrine-containing herbal products have been associated with adverse cardiovascular events, seizures and even death. Ginseng, widely used for its purported physical and mental effects, is generally well tolerated, but it has been implicated as a cause of decreased response to warfarin. Physicians must be alert for adverse effects and drug interactions associated with herbal remedies, and they should ask all patients about the use of these products.  (+info)

Interactions of 6-gingerol and ellagic acid with the cardiac sarcoplasmic reticulum Ca2+-ATPase. (2/156)

The inotropic/lusitropic effects of beta-adrenergic agonists on the heart are mediated largely by protein kinase A (PKA)-catalyzed phosphorylation of phospholamban, the natural protein regulator of the Ca2+ pump present in sarcoplasmic reticulum (SR) membranes. Gingerol, a plant derivative, is known to produce similar effects when tested in isolated cardiac muscle. The purpose of the present study was to compare the effects of gingerol and another plant derivative, ellagic acid, on the kinetics of the SR Ca2+ pump with those of PKA-catalyzed phospholamban phosphorylation to elucidate their mechanisms of Ca2+ pump regulation. As previously demonstrated for PKA, 50 microM gingerol or ellagic acid increased Vmax(Ca) of Ca2+ uptake and Ca2+-ATPase activity assayed at millimolar ATP concentrations in light cardiac SR vesicles. Unlike PKA, which decreases Km(Ca), neither compound had a significant effect on Km(Ca) in unphosphorylated vesicles. However, gingerol increased Km(Ca) in phosphorylated vesicles, in which Ca2+ uptake was significantly increased further at saturating Ca2+ and remained unchanged at subsaturating Ca2+. An inhibition of Ca2+ uptake by gingerol at micromolar MgATP concentrations was overcome with increasing MgATP concentrations. The stimulation of Ca2+ uptake attributable to gingerol in unphosphorylated microsomes at saturating Ca2+ was 30% to 40% when assayed at 0.05 to 2 mM MgATP and only about 12% in phosphorylated microsomes as well as in rabbit fast skeletal muscle light SR. The present results support the view that an ATP-dependent increase in Vmax(Ca) of the SR Ca2+ pump plays an important role in mediating cardiac contractile responses to gingerol and phospholamban-dependent beta-adrenergic stimulation.  (+info)

Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro. (3/156)

Estrogenic isoflavones, such as genistein and daidzein, are present in virtually all natural-ingredient rodent diets that use soy as a source of protein. Since these compounds are endocrine-active, it is important to determine whether the amounts present in rodent diets are sufficient to affect sexual development. The present study consisted of in vitro and in vivo parts. In the in vitro portion, human hepatoma cells were transfected with either rat estrogen receptor (ER) alpha or beta plus an estrogen-responsive luciferase reporter gene. Genistein and daidzein were complete agonists at both ERs, genistein being more potent than daidzein, and both compounds were more potent at ER beta than ER alpha. In combined studies with estradiol, genistein exerted additive effects with estradiol in vitro. In the in vivo portion of the study, groups of six pregnant Sprague-Dawley females were fed one of the following four diets, and the pups were maintained on the same diets until puberty: (1) a natural-ingredient, open-formula rodent diet (NIH-07) containing 16 mg genistein and 14 mg daidzein per 100 g of feed; (2) a soy- and alfalfa-free diet (SAFD) in which casein and corn oil were substituted for soy and alfalfa meal and soy oil, respectively, that contained no detectable isoflavones; (3) SAFD containing 0.02% genistein (GE.02); or (4) SAFD containing 0.1% genistein (GE.1). In the GE.1 group, effects of dietary genistein included a decreased rate of body-weight gain, a markedly increased (2.3-fold) uterine/body weight (U/BW) ratio on postnatal day (pnd) 21, a significant acceleration of puberty among females, and a marginal decrease in the ventral prostate weight on postnatal day (pnd) 56. However, developmental differences among the groups fed SAFD, GE.02, or NIH-07 were small and suggested minimal effects of phytoestrogens at normal dietary levels. In particular, on pnd 21, the U/BW ratio of the GE.02 and NIH-07 groups did not differ significantly from that of the SAFD group. Only one statistically significant difference was detected between groups fed SAFD and NIH-07: the anogenital distance (AGD) of female neonates on pnd 1 whose dams were fed NIH-07 was 12% larger than that of neonates whose dams were fed SAFD. The results suggest that normal amounts of phytoestrogens in natural-ingredient rodent diets may affect one developmental parameter, the female AGD, and that higher doses can affect several other parameters in both males and females. Based on these findings, we do not suggest replacing soy- and alfalfa-based rodent diets with phytoestrogen-free diets in most developmental toxicology studies. However, phytoestrogen-free diets are recommended for endocrine toxicology studies at low doses, to determine whether interactive effects may occur between dietary phytoestrogens and man-made chemicals.  (+info)

Herb-drug interactions: review and assessment of report reliability. (4/156)

AIMS: The aim of this systematic review was to assess the published clinical evidence on interactions between herbal and conventional drugs. METHODS: Four electronic databases were searched for case reports, case series or clinical trials of such interactions. The data were extracted and validated using a scoring system for interaction probability. RESULTS: One hundred and eight cases of suspected interactions were found. 68.5% were classified as 'unable to be evaluated', 13% as 'well-documented' and 18.5% as 'possible' interactions. Warfarin was the most common drug (18 cases) and St John's wort the most common herb (54 cases) involved. CONCLUSION: Herb-drug interactions undoubtedly do occur and may put individuals at risk. However our present knowledge is incomplete and more research is urgently needed.  (+info)

NMR investigations of protein-carbohydrate interactions: insights into the topology of the bound conformation of a lactose isomer and beta-galactosyl xyloses to mistletoe lectin and galectin-1. (5/156)

A hallmark of oligosaccharides is their often limited spatial flexibility, allowing them to access a distinct set of conformers in solution. Viewing each individual or even the complete ensemble of conformations as potential binding partner(s) for lectins in protein-carbohydrate interactions, it is pertinent to address the question on the characteristics of bound state conformation(s) in solution. Also, it is possible that entering the lectin's binding site distorts the low-energy topology of a glycosidic linkage. As a step to delineate the strategy of ligand selection for galactosides, a common physiological docking point, we have performed a NMR study on two non-homologous lectins showing identical monosaccharide specificity. Thus, the conformation of lactose analogues bound to bovine heart galectin-1 and to mistletoe lectin in solution has been determined by transferred nuclear Overhauser effect measurements. It is demonstrated that the lectins select the syn conformation of lactose and various structural analogues (Galbeta(1-->4)Xyl, Galbeta(1-->3)Xyl, Galbeta(1-->2)Xyl, and Galbeta(1-->3)Glc) from the ensemble of presented conformations. No evidence for conformational distortion was obtained. Docking of the analogues to the modeled binding sites furnishes explanations, in structural terms, for exclusive recognition of the syn conformer despite the non-homologous design of the binding sites.  (+info)

St Johns wort increases expression of P-glycoprotein: implications for drug interactions. (6/156)

AIMS: St John's Wort (SJW) is widely used in the treatment of depression but concerns have been raised about its potential to interact with other drugs. Co-administration with SJW has resulted in significant reductions in trough plasma concentrations of indinavir and cyclosporin [1, 2]. Induction of cytochrome P450 3A4 (CYP3A4) has been implicated as the most likely interaction mechanism. However, the magnitude of the interaction seen in clinical practice is greater than that predicted by in vitro studies suggesting additional interaction mechanisms may exist. As indinavir and cyclosporin are substrates for both CYP3A4 and the multi drug transporter P-glycoprotein we hypothesized that modulation of P-glycoprotein expression and function by SJW may contribute to the development of potentially harmful drug-drug interactions. METHODS: Healthy volunteers were randomized to either SJW (0.15%) 600 mg three times daily for 16 days (n = 15) or placebo (n = 7). Blood samples were obtained for P-glycoprotein expression and function at baseline, 16 and 32 days post treatment. Peripheral blood lymphocytes (PBMCs) were isolated by Ficoll density gradient centrifugation, fixed and permeabilized. Cells were stained with a P-glycoprotein specific antibody, quantified by flow cytometry and median fluorescence intensity (MFI) values obtained. Vimentin and IE (nonsense antibody) were used as controls. The presence of the MDR 1 gene product was confirmed by RT-PCR. P-glycoprotein mediated drug efflux was determined as a function of rhodamine efflux in the absence and presence of ritonavir. Data are expressed as mean +/- s.d. and were subjected to nonparametric analysis. RESULTS: P-glycoprotein expression increased 4.2 fold from baseline in subjects treated with SJW (7.0 +/- 1.9 vs 29.5 +/- 14.3 (MFI); P < 0.05). There was no effect with placebo (5.1 +/- 1.3 vs 6.0 +/- 1.9 MFI). SJW increased P-glycoprotein mediated rhodamine efflux (reduced ratio) compared with baseline (0.12 +/- 0.04 vs 0.24 +/- 0.18 P < 0.05). There was no change with placebo. Ritonavir (5 microm) inhibited P-glycoprotein mediated efflux in both groups producing greater intracellular accumulation of rhodamine. However, this effect was attenuated following treatment with SJW (23.9 +/- 15.3% vs 75.4 +/- 16.4% P < 0.05). CONCLUSIONS: SJW increased expression and enhanced the drug efflux function of the multi drug transporter P-glycoprotein in PBMCs of healthy volunteers. This may represent a second mechanism for the drug-herb interactions seen in clinical practice and account for the discrepancies between in vitro and in vivo data. Since P-glycoprotein and CYP3A4 have distinct though overlapping substrates, patients receiving drugs, which are P-glycoprotein substrates should be warned against self-medication with SJW as clinically significant drug interactions may occur.  (+info)

Pharmacokinetic interactions between carbamazepine and the traditional Chinese medicine Paeoniae Radix. (7/156)

The present study was conducted to evaluate the effects of Paeoniae Radix (PR), one of the most famous tonic traditional Chinese medicines, on the pharmacokinetics of carbamazepine (CBZ) in rats and to determine the possible interactions between PR and CBZ. The significant decrease in Tmax indicated that simultaneous oral administration of PR contributed to more rapid absorption of CBZ. It is suggested that the faster absorption of CBZ might lead to the rapid onset of its clinical effect. There were no significant differences in maximum concentration (Cmax), area under the plasma concentration-time curve (AUC), half-life (t1/2), mean residence time (MRT), clearance/bioavailability (CL/F), and apparent volume of distribution/bioavailability (Vd/F) of CBZ between the two groups, showing that PR did not significantly affect the absorption extent, distribution, metabolism, and elimination of CBZ. A significant decrease in protein binding rate was found when CBZ was coadministered with PR. Further studies are in progress to clarify the clinical significance and the mechanism underlying the effects of PR on the protein binding of CBZ observed in the present study.  (+info)

St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. (8/156)

AIMS: The aim of this work is to identify the medicines which interact with the herbal remedy St John's wort (SJW), and the mechanisms responsible. METHODS: A systematic review of all the available evidence, including worldwide published literature and spontaneous case reports provided by healthcare professionals and regulatory authorities within Europe has been undertaken. RESULTS: A number of clinically significant interactions have been identified with prescribed medicines including warfarin, phenprocoumon, cyclosporin, HIV protease inhibitors, theophylline, digoxin and oral contraceptives resulting in a decrease in concentration or effect of the medicines. These interactions are probably due to the induction of cytochrome P450 isoenzymes CYP3A4, CYP2C9, CYP1A2 and the transport protein P-glycoprotein by constituent(s) in SJW. The degree of induction is unpredictable due to factors such as the variable quality and quantity of constituent(s) in SJW preparations. In addition, possible pharmacodynamic interactions with selective serotonin re-uptake inhibitors and serotonin (5-HT(1d)) receptor-agonists such as triptans used to treat migraine were identified. These interactions are associated with an increased risk of adverse reactions. CONCLUSIONS: In Sweden and the UK the potential risks to patients were judged to be significant and therefore information about the interactions was provided to health care professionals and patients. The product information of the licensed medicines involved has been amended to reflect these newly identified interactions and SJW preparations have been voluntarily labelled with appropriate warnings.  (+info)

TY - JOUR. T1 - Pregnancy, prescription medicines and the potential risk of herb-drug interactions. T2 - a cross-sectional survey. AU - McLay, James S.. AU - Izzati, Naila. AU - Pallivalapila, Abdul R.. AU - Shetty, Ashalatha. AU - Pande, Binita. AU - Rore, Craig. AU - Al Hail, Moza. AU - Stewart, Derek. N1 - All funding was from institutional resource. JSM, AS are employed by the University of Aberdeen. DS is employed by the Robert Gordon University. BP and CR are employed by NHS Scotland. ARP and MAH are employed by the Hamad Medical Corporation. Qatar. NI is a postgraduate student at the University of Aberdeen. PY - 2017/12/19. Y1 - 2017/12/19. N2 - Background: Pregnant women are routinely prescribed medicines while self-medicating with herbal natural products to treat predominantly pregnancy related conditions. The aim of this study was to assess the potential for herb-drug interactions (HDIs) in pregnant women and to explore possible herb-drug interactions and their potential clinical ...
Editors Note: NCCAM has posted a free online lecture by Professor Bill J. Gurley, Ph.D., Department of Pharmaceutical Sciences and Clinical Pharmacokinetics Laboratory at the College of Pharmacy, University of Arkansas for Medical Sciences. The lecture identifies factors that contribute to the risk for herb-drug interactions, mechanisms involved in herb-drug interactions, and how new technologies in supplements and drugs may impact herb-drug interaction.. ...
Drug-herb interactions: Mechanisms involved and clinical implications of five commonly and traditionally used herbs;kpubs;
TY - JOUR. T1 - Do herbs increase the risk of herb-drug interactions for patients with arthritis? [8]. AU - Thomsen, M.. AU - Schmidt, M.. AU - Vitetta, L.. AU - Sali, A.. AU - Holden, W.. AU - Joseph, J.. AU - Williamson, L.. PY - 2005/10. Y1 - 2005/10. UR - M3 - Letter. C2 - 16162912. AN - SCOPUS:27744528057. VL - 64. SP - 1527. EP - 1528. JO - Annals of the Rheumatic Diseases. JF - Annals of the Rheumatic Diseases. SN - 0003-4967. IS - 10. ER - ...
Among the 400 patients, 237 (59.3 %) used at least one medicinal herb. Compared to other studies this is a high percentage and similar to previous studies from our country where 51.9 % of diabetic patients reported taking herbs [7] and 85.7 % of hypertensive patients used at least one type of complementary and alternative medicines. Of the users, 62.1 % reported taking herbs [8]. According to the World Health Organization (WHO), about 70 % of the world population use medicinal herbs as complementary or alternative medicine [12], so the use of herbal remedies is common worldwide.. The herbs used by patients in this study are relatively safe because most herbs used here are also edible plants used in cooking so they are not some unknown plants that might be toxic. However, even these plants can have potential drug-herb interactions. In 21.5 % of the users in this study at least one potential drug-herb interaction was found. In a study on patients using dietary supplements in two American cities, ...
Ginko Biloba is a popular herb for overall brain function and memory. It also has a thinning effect on the blood. One of the ways the body works to stop bleeding is by the action of platelets. When platelets come in contact with damaged blood vessel walls they stick together. Ginko biloba inhibits the stickiness of platelets. It should not be taken with other drugs that inhibit blood clots such as warfarin, non-steroidal anti-inflammatories (NSAIDs), and other blood thinners. Ginko may also interact with anti-seizure medications including carbamazepine, phenytoin, and phenobarbital. People taking certain diuretic medications (thiazide diuretics) should not take Ginko as it may cause an increase in blood pressure ...
Abstract:. Background: The influence of poly-herbal formulation (Mehagni) on allopathic drug like glibenclamide mainly on plasma glucose level, lipid level and pharmacokinetic parameters in patients with type-2 diabetes mellitus. Methods and Result: Open-label, randomized clinical study was carried out for 90 days. Around 75 patients were screened out, based on their medication subjects were divided into group A&B 39 patients were in glibenclamide-2.5 mg (Daonil®) therapy and 36 patients were in poly-herbal formulation (Mehagni-500 mg, 2 tab/thrice a day) from past 6 months. Again 39 patients of glibenclamide therapy subdivided into group A1&A2. Group A1 (20) patients reviving glibenclamide-2.5 mg and group A2 (20) for combined study (GLB-1.5 mg+Mehagni 2 tab/twice a day). Initial day the study, analyze baseline demographic and clinical characteristics and that data was compared with end of the study report, in group A2 the high density lipoproteins (HDL) significantly increased as compared to ...
There is a possibility that the effect of tea on blood pressure might differ from that of pure caffeine. There are few data on the effect of tea on blood pressure in patients treated with antihypertensives. One study in stable hypertensive patients taking beta blockers, calcium-channel blockers, nitrates and ACE inhibitors reported that 450 ml of black tea (containing approximately 190 mg of caffeine) increased systolic blood pressure by 5 mmHg two hours after consumption. This effect was similar to the increase seen with a single dose of 200-mg of caffeine. Drinking 900 mL of black tea daily for 4 weeks had no significant effect on blood pressure. However, the acute effects of tea remained: systolic blood pressure was still increased by 5 mmHg two hours after the patients drank 450 mL of black tea.There are a number of short-term intervention studies on the effect of tea on blood pressure, mainly in healthy subjects or patients with untreated mild hypertension. In one meta-analysis of 5 ...
Red vine leaf contains a range of polyphenolics, mainly flavonoids, proanthocyanins and anthocyanins. The major flavonoids in the extract are quercetin and isoquercitrin. Catechins present include gallocatechin and epigallocatechin and their polymers. The red colour is due to the anthocyanins, which are mainly glucosides of malvidin, but also of delphinidin, cyanidin and pertunidin. Hydroxy-cinnamic acids (e.g. caffeic acid) and resveratrol are also present.. ...
TY - JOUR. T1 - Multiple ABC Transporters Efflux Baicalin. AU - Kalapos-Kovács, Bernadett. AU - Magda, Balázs. AU - Jani, Márton. AU - Fekete, Zsolt. AU - Szabó, P.. AU - Antal, I.. AU - Krajcsi, Péter. AU - Klebovich, I.. PY - 2015/12/1. Y1 - 2015/12/1. N2 - Baicalein, the aglycone formed by hydrolysis of baicalin in the intestine, is well absorbed by passive diffusion but subjected to extensive intestinal glucuronidation. Efflux of baicalin, the low passive permeability glucuronide of baicalein from enterocytes, likely depends on a carrier-mediated transport. The present study was designed to explore potential drug-herb interaction by investigating the inhibitory effect of baicalin on the transport of reporter substrates by transporters and to identify the transporters responsible for the efflux of baicalin from enterocytes and hepatocytes. The interaction of baicalin with specific ABC transporters was studied using membranes from cells overexpressing human BCRP, MDR1, MRP2, MRP3 and ...
In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant.
Despite increased awareness of the potential of herb-drug interactions (HDIs), the lack of rigorous clinical evidence regarding the significance provides a challenge for clinicians and consumers to make rational decisions about the safe combination of herbal and conventional medicines. This review addressed HDIs based on evidence from randomized controlled trials (RCTs). Literature was identified by performing a PubMed search till January 2017. Risk description and clinical risk management were described. Among 74 finally included RCTs, 17 RCTs (22.97%) simply addressed pharmacodynamic HDIs. Fifty-seven RCTs (77.03%) investigated pharmacokinetic HDIs and twenty-eight of them showed potential or actual clinical relevance. The extent of an HDI may be associated with the factors such as pharmacogenomics, dose of active ingredients in herbs, time course of interaction, characteristics of the object drugs (e.g., administration routes and pharmacokinetic profiles), modification of herbal
How to integrate plants into your life, soul, and medicine, and how to decide which remedy is the right one. Learn simple plant dowsing techniques and consider herb-drug interactions.. For more information and Registration: 800-829-0918. Payment: $40/ ...
This (admittedly awkwardly-titled) group of enzymes system metabolizes thousands of endogenous (from within) and exogenous (from outside) chemicals. Some seem to play more of a role in drug metabolism than others, and therefore get more scrutiny. 6 of these 50 enzymes metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. (If youve ever punished yourself by reading herb-drug interaction research papers, these may look familiar.) These enzymes are located in many cells of the body, but are especially concentrated in the liver. (For cell physiology enthusiasts, they are located either in the inner membrane of mitochondria, or in the endoplasmic reticulum of cells.). How do these enzymes work? CYP450 enzymes essentially make compounds more soluble so they can be excreted by the body. This enzyme system is a component of Phase 1 detoxification. You might be familiar with Phase 1, 2, and 3 metabolism in the liver. You can think of phase 1 as modification. In ...
Prediction may be envisaged as organized thinking about the possible. For this purpose, dynamic models of the state-variable approach are important tools because they combine basic knowledge on the physical, chemical and physiological processes that underlie crop growth and agricultural production. At one extreme are comprehensive models that claim to integrate all aspects of growth and to focus attention on the main gaps in present operational knowledge. As such, they are research tools. At the other extreme are summarizing models that are especially geared to answer w hat-if questions and are used for evaluating regional production potentials and constraints, for irrigation management and integrated control of pests, diseases and weeds. Examples of these types of models are given and their usefulness for predictive purposes is discussed. ...
Department of Terrestrial Microbial Ecology (TME) Centre for Terrestrial Ecology (CTE) Netherlands Institute of Ecology (NIOO-KNAW). The research of TME delivers basic knowledge on the ecology, diversity and evolution of below- and above-ground microorganisms, particularly those in the rhizosphere (plant root zone), mycosphere (zone surrounding fungi), and phyllosphere (plant leaf surface). Questions we aim to answer include: what effect do plant surfaces and fungal hyphae exert on the structure and activity of their associated bacterial communities and how do microbial interactivities influence the functioning of plant- and fungus-associated microbial communities with special focus on mutualistic, pathogenic and antagonistic micro-organisms? TME is also member of the Ecogenomics Consortium (, which aims to explore and unlock the sustainable life-support functions of soils through an ecogenomic approach. ...
Aims: To teach the students basic knowledge on interaction processes of radiation with matter as a basis for radiation detection, basic instrumentation in radiation detection, detector types and formation of electric pulses in them, interpretation of various spectra, energy resolution, energy and efficiency calibrations. Since ICP-MS is becoming a standard method for the measurement of many radionuclides basics on mass spectrometric measurement of radionuclides should also be at least shortly covered. Topics - interaction processes of radiation with matter (ionization, scattering, excitation, formation ...
This course was designed to provide basic knowledge on the use of the biological model zebrafish with main emphasis on its use in the context of the study of human diseases and biomedical sciences ...
This course was designed to provide basic knowledge on the use of the biological model zebrafish with main emphasis on its use in the context of the study of human diseases and biomedical sciences ...
This course was designed to provide basic knowledge on the use of the biological model zebrafish with main emphasis on its use in the context of the study of human diseases and biomedical sciences ...
Maternity Nursing I. Basic Knowledge on Genetics and Obstetrics 1. DNA - Deoxyribonucleic Acid - carries genetic code 2. Chromosomes - threadlike structure...
Backcountry Survival in Your Backpack: Just because your gear pack is filled with survival and avalanche rescue essentials without basic knowledge on how to use the gear the victim may lay in more danger due to the rescuer learning how to use the equipment while on the job.
The Healthy Communities Research Centre at UQ Ipswich is calling for a national focus on health literacy following the release of findings which reveal that most Australians dont have the basic knowledge to keep themselves healthy.
There are some good reasons why natural remedies for RLS are a preferred solution to conventional medications. Conventional medications are temporarily effective, but they have side effects (such as fatigue, dry mouth, weight gain, and brain fog), and their powers may be limited. The medicines tend to stop working after 2 or 3 years, though […]. ...
Pacific BioLogic Formulas - Chinese Herbal Supplements. Call Forrest Health at (408)354-4262 for information about natural health products.
Complete range of natural herbal supplements and health products at discount prices. Shop and save on herbal vitamins, oil, extract, and single herbs.
It is said that there are over 100 different training methodologies available to ... Tell the trainee what youre going to train. ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on - id: 24933a-NjNiM
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): multi-input, multi-output feed-back control design for linear systems using the paradigms, theory, and tools of robust con-trol that have arisen during the past two decades. The book is aimed at graduate students and practicing engineers who have a basic knowledge of classical con-trol design and state-space con-trol theory for linear systems. A basic knowledge of matrix theory and linear algebra is required to appreciate and digest the material offered. This edition is a revised and expanded version of the first edition, which was published in 1996. The size of the
The Center of Excellence for Natural Product-Drug Interaction Research (NaPDI) provides leadership in the study of natural product-drug interactions, with the ultimate goal of developing a definitive approach to determine the clinical relevance of pharmacokinetic interactions between natural products (NPs) and conventional medications.
Ulcerative colitis is a serious nicely being situation involving irritation, ulceration, and bleeding of the colon. Its thought-about to be an auto-immune state of affairs for which conventional medication has no remedy. The patient is given steroids and different medicine to regulate flare-ups and bleeding. The one treatment is to take away the affected person colon. This illness can both be minor with occasional flare-ups or debilitating and excessive. The inside bleeding may cause excessive anemia. Diarrhea could cause an absence of fluids and electrolytes. The ache from intestinal spasms shall be excessive. It may get to the point that … Read the rest Learn more → ...
Health Products & Services are essential self growth tools for those looking to improve their health and wellness through physical fitness, herbal supplements, and mental enrichment.
Health Products & Services are essential self growth tools for those looking to improve their health and wellness through physical fitness, herbal supplements, and mental enrichment.
Health, Safety and Environment (HSE) considerations are vital to every enterprise. Moreover, HSE requirements in the workplace are laid down in a whole range of laws, regulations and guidelines. The employer has the primary responsibility for providing a suitable, safe working environment - and for ensuring sufficient training. This HSE Introduction provides you with the basic knowledge you need to know to be able to deal with HSE challenges in your daily work ...
The neglect of fundamental research into perovskites in favor of close focus on its solar applications has left holes in basic knowledge about the material itself.
Populations in developing areas of this region lack basic knowledge of biology and physiology, so it is imperative that educators use simple techniques when teaching nutrition.
quote=No Boy Scout will ignore a plea for help. However, the desire to help is of little use unless one knows how to give the proper aid. The main purpose of the Lifesaving merit badge is to prepare Scouts to assist those involved in water accidents, teaching them the basic knowledge of rescue techniques, the skills to perform them, and the judgment to know when and how to act so that they can be prepared for emergencies ...
quote=No Boy Scout will ignore a plea for help. However, the desire to help is of little use unless one knows how to give the proper aid. The main purpose of the Lifesaving merit badge is to prepare Scouts to assist those involved in water accidents, teaching them the basic knowledge of rescue techniques, the skills to perform them, and the judgment to know when and how to act so that they can be prepared for emergencies ...
28th Feb, 2018: This one-day course offers an introduction to the uses and functions of the statistical software Stata including data entry and manipulation, do-files, and the basics of analyses and graphs. The course is ideally suited to those with little/no experience with Stata, but basic knowledge of statistics is advantageous. ...
Well, theres a little bit of land called Kashmir that should be basic knowledge for anyone who has passed Freshmen level World History. Muslims and...
We are excited to announce the launch of new website for Principle and method of the experiment. This website will enable you to access information about the basic knowledge of experiments using antibodies, ELISA kits and so on. Check our website to help your experiments ...
Welcome to the Furry Thread! General Links - What is the Furry Fandom? - What is Furry Art about? Look to this video for some basic knowledge: ...
Welcome to the Furry Thread! General Links - What is the Furry Fandom? - What is Furry Art about? Look to this video for some basic knowledge: ...
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Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions exist between selected commercially available herbal products (i.e., Linctagon Forte®, Viral Choice® and Canova®) and indinavir in terms of in vitro transport and metabolism. Bi-directional transport of indinavir was evaluated across Caco-2 cell monolayers in the presence and absence of the selected herbal products and verapamil (positive control). Metabolism of indinavir was determined in LS180 cells in the presence and absence of the selected herbal products as well as ketoconazole (positive control). The secretory transport of indinavir increased in a concentration dependent way in the presence of Linctagon Forte® and Viral Choice® when compared to that of indinavir alone. Canova® only slightly affected the efflux of indinavir compared to that of the control group. There
1. Depression Treatment- One of the scientifically proven St Johns Wort benefits is that this herb increases serotonin levels in the brain. This effect is the reason that the herb is commonly used to treat depression. 2. Anxiety Treatment- With the proper St Johns Wort dosage the herb can be effective for treating anxiety and related conditions. The effect that St. Johns Wort has on many of the neurotransmitters in the brain makes it a good choice for this disorder. 3. Smoking Cessation Support- St Johns Wort can help lessen the withdrawal symptoms and cravings that you experience when you stop smoking cigarettes. 4. PMS Treatment- Treating PMS is one of the top St Johns Wort benefits for many women. The use of this herb can minimize or even eliminate the symptoms of PMS and provide relief. 5. Obsessive Compulsive Treatment- St Johns Wort depression treatment is well known. What is less known is that this herb can also help treat obsessive compulsive disorder and certain other mental ...
It has been well reported that complementary medicines can significantly alter the way the body handles conventional drugs, leading to potential fatal herb-drug interactions. The aim of the present study was to investigate the molecular mechanism of drug interactions involving St Johns wort (SJW) (Hypericum perforatum L), a popular herbal medicine widely used for depression, particularly examining changes in the expression of cytochrome P450 CYP3A, the most abundant drug metabolising CYP enzymes in man. Eighteen Sprague-Dawley (SD) rats were assigned randomly into 3 groups (n = 6/group): control, low dose and high dose (500 and 1000 mg/kg/day of SJW, equal to 1500 and 3000 μg/kg/day of Hypericin). Each group was treated with SJW or control preparation, by gastric gavage, for 14 consecutive days. Liver and intestinal CYP3A activity and protein and mRNA levels, from fi ve segments of the intestine, were examined using CYP3A-dependent erythromycin N-demethylation activity assay, quantitative ...
Echinacea is the name of a genus of native North American plants, commonly known as the purple coneflower. The most widely used herbal product in the United States is a liquid extract made from the root of Echinacea purpurea. Because the active component of the plant has not been identified, commercial echinacea products are not typically standardized to any particular component. The research literature on echinacea is difficult to evaluate because of the heterogeneity of the products used in various studies. The herb has been recommended as a prophylactic treatment for upper respiratory infection and is widely used for this indication. However, based on the current literature, it appears that prophylactic echinacea does not have a significant impact on the frequency, severity, or duration of upper respiratory infection. The data regarding treatment of upper respiratory infection appear to support a modest positive effect. No significant herb-drug interactions with echinacea have been reported; adverse
when combining prescription medication and herbal medicine and what is hype?. 2. We discuss the ten herb-drug interactions that every naturopathic physician and clinical herbalist should understand. Herbs discussed are St Johnswort, saw palmetto, milk thistle, goldenseal, cannabis/hemp and others.. 3. We describe the difference between botanicals that are cytochrome P-450 inducers and those that are inhibitors, and those that are neutral to the liver detox system.. 4. We review 10 herbs and potential for drug interactions of grapefruit, Hypericum, milk thistle, ginkgo, saw palmetto, goldenseal, green tea, black tea, echinacea, and fiber-rich plants. And finally we review the top 15 drugs and potential for herb interactions including Lisinopril, Atorvastatin, Metformin, Metoprolol, Omeprazole, Levothyroxine, Albuterol, Gabapentin, Acetaminophen, Atenolol, Steroids, Amoxicillin, Cannabis, Hemp and others.. Continuing education (CE) credits: More CE details.. ...
Background: Use of herbal medicines alongside conventional anticancer drugs is common among cancer patients. This may potentially cause reduced adherence to conventional anti-cancer drugs, unpredictable side effects and unknown drug-herb interactions. This in the long run could result in poor clinical outcomes.. Aim: This study was conducted to investigate how use of herbal medicines affects adherence to conventional anti-cancer drugs, to determine the proportion of patients using both conventional and herbal anticancer medicines and to identify the common herbal medicines used alongside conventional anti-cancer drugs by patients at the Mbarara Regional Referral Hospital Oncology unit.. Methods and Findings: A cross-sectional study was conducted in the oncology clinic of Mbarara Regional Referral Hospital found in Mbarara district, Uganda. Data was collected between 20thMarch and 20th April 2019 from 122 participants who met the inclusion criteria with subsequent consenting. Our primary outcome ...
The Schisandraceae family is reported to have a range of pharmacological activities, including anti-inflammatory effects. As with all herbal preparations, extracts of Schisandra species are mixtures composed of ,50 lignans including schizandrins and deoxyschizandrins. In China, Schisandra sphenanthera extract (SSE) is often co-administered with immunosuppressant treatment of transplant recipients. In cases of co-administration, the potential for herb-drug interactions (HDI) increases. Clinical studies have been employed to assess HDI of extracts including SSE. Clinical results demonstrated that chronic SSE administration reduced midazolam (MDZ) clearance by 55.4% in healthy volunteers. While clinical studies are definitive and considered the gold standard, these studies are impractical for routine HDI assessments. Alternatively, in vitro strategies can be utilized to reduce the need for clinical studies. Transporter Certified™ human hepatocytes in sandwich-culture (SCHH) provide a fully ...
Get tips on using 5-HTP supplements once you talk with your doctor about them. Here's a partial list of possible drug-herb interactions.
Hepatotoxicity is an undesirable condition of the liver, often occurring due to the interaction of drugs. Although different methods have been employed in the diagnosis of drug-induced hepatotoxicity, none have accurately proven the hepatotoxic effect of drug-drug interactions or drug-herb interactions. Flavonoids of aspalathin-rich green Rooibos extract (GRT) present many therapeutic properties that reduce the risk of developing cardiovascular diseases. However, there is a gap in literature regarding the efficacy or safety of this particular extract on the liver. Furthermore, Rooibos has been implicated in the development of hepatotoxicity which might have been triggered by drug-Rooibos interaction. This study therefore purposes to establish whether consumption of an aspalathin-rich green Rooibos extract (GRT) has any toxic effects on the liver using both an in vitro human liver cell line (C3A) model, as well as a sub-chronic Sprague- Dawley rat model. Cultured C3A cells were treated with ...
KarmaMood St Johns Wort Tablets. St Johns Wort Extract 250mg. A Traditional Herbal Remedy for the relief of low mood and symptoms of anxiety. Buy direct.
St Johns Wort helps cold hands? St Johns Wort, the herb widely used to treat depression, may help patients with Raynauds syndrome, a condition that makes sufferers fingers and toes go white and numb. In a new Canadian trial, patients will take three 300mg tablets, three times a day for six weeks. It is hoped the he
Of course, you could experience side effects from taking valerian root. First of all, you need to ensure it wont interfere with other medications and supplements you may be taking.. The Clinical Pharmacology and Therapeutics journal published a study in 2005 that concluded that valerian had no measurable herb-drug interaction, but its best to talk to your doctor.. Some people may have trouble digesting and breaking down this natural remedy, which could cause stomachaches and prevent people from falling asleep.. Consuming valerian for insomnia may obviously cause drowsiness, so it shouldnt be taken before driving or other activity that requires your full attention.. Phytomedicine published a study in 2006 in which valerian was reported as being safe with no side effects. In this study, valerian seemed to positively impact sperm quality. If you are having trouble sleeping AND conceiving, it may be worth your while to contact a naturopath to discuss what valerian could do for you.. ...
BACKGROUND: Food/Herb-drug interactions have become a major problem in health care. These interactions can lead to loss of therapeutic efficacy or toxic effects of drugs. AREAS OF UNCERTAINTY: To probe the clinical relevance of such interactions, the impact of food/herb intake on the clinical effects of drug administration has to be evaluated. Failure to identify and efficiently manage food-drug interactions can lead to serious consequences. A comprehensive knowledge of the mechanisms that underpin variability in disposition will help optimize therapy ...
Order Golden Rule St Johns Wort shrubs, Hypericum calycinum NCHCI, on sale at, Americas largest online plant nursery.
St Johns Wort for Diabetes - There have been Proven Instances for this herb to Produce an Excellent Outcome in Treating Diabetes. Natural Remedy for Diabetes
In vivo studies suggest that extracts of St Johns wort may have apoptotic effects on cancer cells, but human studies have not been conducted.
Bio Health Hyperidrine (St Johns Wort) is a traditional herbal medicinal product used to relieve the symptoms of slightly low mood and mild anxiety, based on traditional use only.
Find patient medical information for ST JOHNS WORT on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products that have it.
St Johns Wort has a lot of evidence backing up its use for mild depresssion. It can safely be tried while observing a few sensible cautions.
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Is Hypertension Caused by St Johns Wort It is important to be able to recognize the signs of high blood pressure, but it is also important to know
Provide basic knowledge on the most common diseases affecting the oral cavity, the basic concepts of the main oral diseases and strategies related to their prevention; the main techniques and related types of instruments for professional oral hygiene; the use of the main databases of Biomedical interest; the materials and techniques that can be used in cosmetic dentistry. The student will acquire the ability to correctly apply the dental hygiene methods and the recognition of inflammatory gingival, periodontal and peri-implantal alterations. MODULE PRACTICAL ACTIVITY IN DENTAL HYGIENE Training objectives. The student will learn about the main techniques and related types of instruments for professional oral hygiene above and subgingival. MODULE PRACTICAL ACTIVITY IN CLINICAL PROPEDEUTICS Training objectives. The student must acquire the main procedures relating to the management processes of the dental clinic in relation to the organization and preparation of the instruments. It must be able to ...
This course is designed to help the Shipper/Receiver operate a forklift efficiently, effectively and safely. You will receive basic knowledge on the
Learn more about Iron Supplements May Prevent Anemia During Pregnancy at Portsmouth Regional Hospital Iron Supplements May Prevent Anemia During Pregnancy ...
Heart Diseases Treatment in Ayurveda - Basic Knowledge :: According to Ayurveda, poor diet, stress, unhealthy lifestyle causes impairment of digestion which causes accumulation of toxins in the body. These toxins get deposited in different part of the body, such as the coronary artery that leads to obstruction, poor circulation and causes various forms of heart disease.
Some people may use St Johns wort to treat depression or other health conditions. This eMedTV page explores common side effects of the supplement and offers a link to more information. St. Johns wart is a common misspelling of St. Johns wort.
St John’s Wort has been recognised for centuries and is often referred to as the sunshine herb. Hypericum… by Power Health from the Health Shop at WWSM
Instead of taking prescribed antidepressants, try St. Johns Wort for the effective treatment of the symptoms of mild to moderate cases of depression.
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Found an interesting article(across multiple sites) that states taking bodybuilding supplements may increase risk of TC. Links to articles : http://www.medicaldaily
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CWI Medical carries Black Cohosh, which is an herbal supplement that supports menopausal health. Studies document Black Cohoshs ability to help support the physical changes which occur in a womans body over time
Potential interactions between conventional medications and natural products, including herbal products, are increasingly recognized in clinical practice. Despite concerns of clinicians, consumers, and regulators regarding unwanted natural product-drug interactions, systematic approaches to identify and characterize the risk of these interactions remain elusive. Approaches focusing on the adaptation of established paradigms used to assess drug-drug interaction risk have been proposed to elucidate natural product-drug interaction risk (Won et al., 2010, 2012; National Center for Complementary and Alternative Medicine, 2012; Brantley et al., 2013, 2014a,b; Ainslie et al., 2014; Gufford et al., 2014a; Barr et al., 2015). Assessment of these interactions involves challenges that extend beyond drug-drug interactions (Gufford et al., 2014b). Unlike drugs, natural products frequently are mixtures of potentially bioactive constituents with immense compositional variation both within and between lots. A ...
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The specialization in History provides a basic overview of historical development from a general perspective, as well as Norwegian history from an international view-point. Through the course of study, students will be given a basic knowledge of historical methodology and theory. Furthermore, education in generating historical material, as well as developing proficiency in critical and independent assessment of historical material is also emphasized. In order to achieve a more thorough insight into academic debates, sources and research methods, students will, in addition to basic knowledge, be given the opportunity to specialize in selected topics or periods. The interpretation of history is dependent on the contemporary context in which the approach and analysis is conducted. Consequently, the common views on major historical events and directions depends on the present time and context. Students may choose to focus on the development of historical research in order to acquire an understanding ...
Surgery: The girls who had a good basic knowledge but were not that good in Ex. got relatively high marks in their clinical exam BUT girls who were great in Ex & not that good in the basic knowledge got relatively low marks! SO…try to read as much as you can in your 5 weeks ...
Mark Zamora, a lawyer in Georgia: A good read about how supplements affect the liver: A 10-year study by investigators tasked with tracking the primary causes of liver injury has found that although conventional medications continue to be a major contributing factor, the proportion of cases tied to herbal and dietary supplements (HDS) is growing at a nearly threefold faster pace. Products marketed for bodybuilding were a common type of HDS causing liver abnormalities, the investigators reported (Hepatology 2014;60:1399-1408). But the most severe outcomes-liver transplantation and death-were seen in patients who ingested non-bodybuilding formulations. Middle-aged women were among the most …. ...
The effect of emotions, foods, etc. on the attack After taking all these points (and many more) into consideration, the physician arrives at a constitutional remedy that heals the condition from the root level without causing any suppression.. In cases that are not very severe, Natural Treatment can also help to reduce the need for conventional medications as well as reduce their dosage. There is reduced dependency on bronchodilators and steroid inhalers with continued natural treatment. People who regularly use steroid inhalers (and large doses of the same for a long time) must watch out for side-effects of the same such as ...
Conventional Medication and Home Remedies for Oral Herpes that Really Work. How to treat oral herpes? Oral herpes is like an annoying house guest you cant get to leave but you can lock in the basement.
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Get an in-depth review and ask questions about St Johns University-New York including academics, college rankings, and more. See what people are saying about St Johns University-New York.
This web site has not been reviewed by the Food and Drug Administration and is not intended to diagnose, treat or cure any disease or dysfunction. If you have a physical concern, and before taking any herbal supplements, it is recommended that you seek the advice of a health care professional. Self diagnoses may create health concerns and some herbal supplements may have adverse effects when combined with prescriptions, over the counter medications, or other herbal supplements.. ...
Soy supplements do not protect women against breast cancer, a new study suggests. The findings are consistent with the results of previous studies that examined
Get info about St Johns University dining options. Nursing is one of the fastest-growing job areas, and for good reason. As the population ages, medical care will continue to expand rapidly.
This supplementary book for the social, behavioral, and health sciences helps readers with no prior knowledge of IBM® SPSS® Statistics, statistics, or mathematics learn the basics of SPSS. Designed to reduce fear and build confidence, the book guides readers through point-and-click sequences using clear examples from real scientific research and invites them to replicate the findings. Relevant outcomes are provided for reference, and exercises at the end of Chapters 2 - 5 provide additional practice. After reading the book and using the program, readers will come away with a basic knowledge of the most commonly used procedures in statistics ...
2010). Herb-Drug Interactions in Oncology. PMPH-USA. p. 146. ISBN 9781607950417. CS1 maint: Uses authors parameter (link) ... 2008). Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies. Elsevier Health Sciences. p. 17 ... Cascara was found in more drug preparations than any other natural product in North America, and is believed to be the most ... Castleman, Michael (2010). The New Healing Herbs: The Essential Guide to More Than 125 of Nature's Most Potent Herbal Remedies ...
"Herb-Drug Interactions". NCCIH. 10 September 2015. Retrieved 26 June 2019. Kuhn, Merrily A. (1 April 2002). "Herbal Remedies: ... There is also concern with respect to the numerous well-established interactions of herbs and drugs. In consultation with a ... Izzo, Angelo A. (2012). "Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data". Medical Principles ... Drug-Herb Interactions". Critical Care Nurse. 22 (2): 22-32. doi:10.4037/ccn2002.22.2.22. PMID 11961942. Spolarich, AE; Andrews ...
Fugh-Berman, Adriane (2000). "Herb-drug interactions". The Lancet. 355 (9198): 134-138. doi:10.1016/S0140-6736(99)06457-0. PMID ... In the classic Handbook of Traditional Drugs from 1941, 517 drugs were listed - 442 were plant parts, 45 were animal parts, and ... Heather McIver TCM Herb Master List, Healthy Tao Herbs Archived 2011-07-11 at the Wayback Machine "The Treatment of 75 Cases of ... It is boiled in a decoction with other herbs prior to ingestion. If it is to be used in a formula to stop heavy bleeding; it is ...
People's Medicine Publishing House (PMPH USA). ISBN 978-1-550-09280-6. Cassileth, Barrie (2010). Herb-Drug Interactions in ...
CS1 maint: discouraged parameter (link) Barrie R. Cassileth; K. Simon Yeung; Jyothirmai Gubili (2010). Herb-drug Interactions ... and from Tijuana itself become a less desirable destination as a result of a decline brought on by the war on drugs. Moss also ...
Cassileth BR, Yeung KS, Gubili J (2010). "Polydox". Herb-drug Interactions in Oncology. PMPH-USA. p. 536. ISBN 978-1-60795-041- ...
Nekvindová, J.; Anzenbacher, P. (July 2007). "Interactions of food and dietary supplements with drug metabolising cytochrome ... Born, D.; Barron, ML (May 2005). "Herb use in pregnancy: what nurses should know". MCN Am J Matern Child Nurs. 30 (3): 201-6. ... Drug discovery[edit]. The anticancer drug taxol was developed after screening of the Pacific yew, Taxus brevifolia (foliage and ... Further information: Herbalism, Psychoactive drug, and Drug Discovery. Plant medicines are in wide use around the world.[81] In ...
Stargrove MB, Treasure J, McKee DL (2008). Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic ...
Stargrove, Mitchell (2007-12-20). Herb, nutrient, and drug interactions : clinical implications and therapeutic strategies (1 ... Drug interactions[edit]. β-Carotene can interact with medication used for lowering cholesterol. Taking them together can lower ... "Beta-Carotene Interactions". Retrieved 28 May 2012.. *^ University of Maryland Medical Center. "Possible Interactions with Beta ... Interactions between factors. Symmetric and asymmetric cleavage[edit]. In the molecular chain between the two cyclohexyl rings ...
Wittkowsky AK (September 2001). "Drug interactions update: drugs, herbs, and oral anticoagulation". Journal of Thrombosis and ... DOACs have fewer drug interactions, no known dietary interactions, wider therapeutic index, and have conventional dosing that ... Harder, Sebastian; Thürmann, Petra (June 1996). "Clinically Important Drug Interactions with Anticoagulants: An Update". ... Anticoagulants are closely related to antiplatelet drugs and thrombolytic drugs by manipulating the various pathways of blood ...
Stargrove MB, Treasure J, McKee DL (2008). Herb, nutrient, and drug interactions : clinical implications and therapeutic ... "Drugs@FDA: FDA-Approved Drugs". Retrieved 21 July 2020. "Drugs@FDA: FDA-Approved Drugs". www.accessdata ... "Drugs@FDA: FDA-Approved Drugs". Retrieved 21 July 2020. "2009 Top 200 branded drugs by total ... Drug Metabolism and Drug Interactions. 19 (1): 41-8. doi:10.1515/dmdi.2002.19.1.41. PMID 12222753. S2CID 26919498. May M, ...
Meijerman I, Beijnen JH, Schellens JH (2006). "Herb-drug interactions in oncology: focus on mechanisms of induction". The ... "Drug Interactions & Labeling - Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers". www.fda. ... "Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers". U.S. Food and Drug Administration. 2019- ... "Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers". Alkattan, A., & Alsalameen, E. (2021). ...
McKee, Mitchell Bebel Stargrove, Jonathan Treasure, Dwight L. (2008). Herb, nutrient, and drug interactions : clinical ... General polydipsia psychogenic polydipsia diuretic drugs, osmotic diuresis Urinary system interstitial cystitis urinary tract ...
"Herb-drug interactions: a literature review". Drugs. 65 (9): 1239-82. doi:10.2165/00003495-200565090-00005. PMID 15916450. ... Potential drug interactions involving at least one CNS depressant were observed for 84% of midazolam users who were ... Kawano DF, Ueta J, Sankarankutty AK, Pereira LR, de Freitas O (June 2009). "Midazolam-related drug interactions: detection of ... Arayne MS, Sultana N, Bibi Z (October 2005). "Grape fruit juice-drug interactions". Pakistan Journal of Pharmaceutical Sciences ...
"Butcher's Broom Effectiveness, Safety, and Drug Interactions on RxList". RxList. Retrieved 2018-11-28. Jakobsson, Hugo; Farmaki ... Abascal, Kathy; Yarnell, Eric (June 2002). "Butcher's Broom: Herb's Potentials Too-Often Swept Under the Rug". Alternative and ...
Pharmacokinetic profile and potential herb-drug interactions". Frontiers in Pharmacology. 5: 162. doi:10.3389/fphar.2014.00162 ...
Wittkowsky AK (September 2001). "Drug interactions update: drugs, herbs, and oral anticoagulation". J. Thromb. Thrombolysis. 12 ... Anticoagulants are closely related to antiplatelet drugs and thrombolytic drugs by manipulating the various pathways of blood ... InteractionsEdit. Foods and food supplements with blood-thinning effects include nattokinase, lumbrokinase, beer, bilberry, ... Drugs such as rivaroxaban, apixaban and edoxaban work by inhibiting factor Xa directly (unlike the heparins and fondaparinux, ...
... it is unknown if a clinically significant drug-herb interaction exists with antiplatelet/anticoagulant drugs. However, until ... Miller, LG (1998). "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions ... as it may cause herb-drug interaction. "Chamomile consists of several ingredients including coumarin, glycoside, herniarin, ... Use of chamomile has potential to cause adverse interactions with numerous herbal products and prescription drugs, and may ...
Miller, LG (1998). "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions ... In 2001, the United States Food and Drug Administration issued a ban of comfrey products marketed for internal use, and a ... Retrieved 25 March 2014.CS1 maint: multiple names: authors list (link) "Comfrey". 17 July 2017. Retrieved 22 May ... healing herb, blackwort, bruisewort, wallwort, gum plant The Russian comfrey 'Bocking 14' cultivar was developed during the ...
Borrelli, F; Izzo, AA (December 2009). "Herb-drug interactions with St John's wort (Hypericum perforatum): an update on ... John's wort drug interactions". Curr. Drug Metab. 9 (10): 1027-37. doi:10.2174/138920008786927767. PMID 19075619. Reiner, Ralph ... "Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, ... and clinical drug-drug interactions". Phytotherapy Research. 28 (5): 643-655. doi:10.1002/ptr.5050. PMID 23897801. S2CID ...
Wittkowsky AK (September 2001). "Drug interactions update: drugs, herbs, and oral anticoagulation". Journal of Thrombosis and ... DOACs have fewer drug interactions, no known dietary interactions, wider therapeutic index, and have conventional dosing that ... Harder, Sebastian; Thürmann, Petra (June 1996). "Clinically Important Drug Interactions with Anticoagulants: An Update". ... herbal medicines and drug interactions". Blood Reviews. 31 (4): 193-203. doi:10.1016/j.blre.2017.02.001. PMID 28196633.. ...
McKee, Mitchell Bebel Stargrove, Jonathan Treasure, Dwight L. (2008). Herb, nutrient, and drug interactions : clinical ... Fischer, Janos (2010). Analogue-based Drug Discovery II. John Wiley & Sons. str. 49. ISBN 978-3-527-63212-1. . Arhivirano iz ... A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus". Drugs. 49 (5): 721- ... Hundal RS, Inzucchi SE (2003). "Metformin: new understandings, new uses". Drugs. 63 (18): 1879-1894. doi:10.2165/00003495- ...
Other drugs that may have interactions with diazepam include antipsychotics (e.g. chlorpromazine), MAO inhibitors, and ... Because it acts on the GABA receptor, the herb valerian may produce an adverse effect. Foods that acidify the urine can lead to ... Diazepam drug misuse can occur either through recreational misuse where the drug is taken to achieve a high or when the drug is ... Holt, Gary A. (1998). Food and Drug Interactions: A Guide for Consumers. Chicago: Precept Press. pp. 90-91. ISBN 978-0-944496- ...
As with all herbs, it is wise to be aware of possible drug interactions and adverse effects. The prevalence of IBS varies by ... Mesalazine is a drug with anti-inflammatory properties that has been reported to significantly reduce immune mediated ... The use of antispasmodic drugs (e.g., anticholinergics such as hyoscyamine or dicyclomine) may help people who have cramps or ... Magnesium aluminum silicates and alverine citrate drugs can be effective for IBS. Rifaximin may be useful as a treatment for ...
The use of apple cider vinegar may cause interactions with prescription drugs, such as insulin or diuretics. Food portal Mother ... 2010). "Apple Cider Vinegar". Natural Standard Herb & Supplement Guide: An Evidence-Based Reference (1st ed.). Elsevier. p. 59 ... ISBN 978-0-323-07295-3. "Apple cider vinegar". 29 May 2018. Retrieved 29 August 2019. Katherine Zeratsky (16 May ...
This supplement may also interfere with other medicines, and potential interactions between it and drugs and herbs are possible ... In Canada, prasterone is a Controlled Drug listed under Section 23 of Schedule IV of the Controlled Drugs and Substances Act ... Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 566-. ISBN 978-3-7692- ... Mayo gets 10-game drug suspension, ESPN, January 27, 2011. "US 400m star LaShawn Merritt fails drug test". BBC Sport. 22 April ...
There is also concern with respect to the numerous well-established interactions of herbs and drugs.[41] In consultation with a ... that whole herbs are more effective than molecules isolated from the plants, herbs are superior to drugs, the doctrine of ... which is often a legally restricted herb, ayurvedic remedies, broom, chaparral, Chinese herb mixtures, comfrey, herbs ... Some herbs may amplify the effects of anticoagulants.[53] Certain herbs as well as common fruit interfere with cytochrome P450 ...
McKee, Mitchell Bebel Stargrove, Jonathan Treasure, Dwight L. (2008). Herb, nutrient, and drug interactions : clinical ... 29 November 2016). "Drug interventions for the treatment of obesity in children and adolescents". The Cochrane Database of ... Morley, LC; Tang, T; Yasmin, E; Norman, RJ; Balen, AH (29 November 2017). "Insulin-sensitising drugs (metformin, rosiglitazone ... "Drugs for anovulatory infertility in polycystic ovary syndrome". BMJ 332 (7556): 1461-62. doi:10.1136/bmj.332.7556.1461 ...
Dasgupta, Amitava; Hammett-Stabler, Catherine A (2011). Herbal Supplements: Efficacy, Toxicity, Interactions with Western Drugs ... See also: List of herbs with known adverse effects. Adequacy of regulation and CAM safety. Many of the claims regarding the ... Some herbal remedies can cause dangerous interactions with chemotherapy drugs, radiation therapy, or anesthetics during surgery ... De Smet, Peter A.G.M. (December 1997). "The Role of Plant-Derived Drugs and Herbal Medicines in Healthcare". Drugs. 54 (6): 801 ...
Edited by, James Hastings, John Alexander Selbie, Louis Herbert Gray, vol. 10, p. 506. Encyclopaedia of Religion and Ethics. ... "Iran's festive drink and drugs binge". BBC World News. March 27, 2009.. ... Sabzi polow with fish (Iranians): A traditional New Year's Day meal of rice with green herbs, served with fish. The traditional ... Kuku sabzi (Iranians): Herbs and vegetable soufflé, traditionally served for dinner on New Year's. It is a light and fluffy ...
Kusimba, Sibel (2003). African Foragers: Environment, Technology, Interactions. Rowman Altamira. p. 285. ISBN 0-7591-0154-X.. ... Upper Paleolithic cultures appear to have had significant knowledge about plants and herbs and may have, albeit very rarely, ...
Herbs. Aquavit. Bénédictine. Brennivín. Crème de menthe. Metaxa. Unicum. Honey. Bärenjäger. Drambuie. Glayva. Krupnik. Juniper ... Various health authorities, including Health Canada and the U.S. Food and Drug Administration (FDA), consider kōji-kin (A. ... Herbs de Majorca. Mastika. Ouzo. Pastis. Rakı. Sambuca. Blackthorn shrub. Patxaran. Chili peppers. Pertsivka. Chocolate. ... Sake can have many flavor notes, such as fruits, flowers, herbs, and spices. Many types of sake have notes of apple from ethyl ...
Pharmacology is the study of drugs and their actions.. *Photobiology is the study of the interactions between non-ionizing ... For example, a medicine man would apply herbs and say prayers for healing, or an ancient philosopher and physician would apply ... of Essential Drugs and Medicines Policy (2002). "Traditional medicine: growing needs and potential". World Health Organization. ... Medications (Rx): what drugs the patient takes including prescribed, over-the-counter, and home remedies, as well as ...
Herbert L. Jones and the Origins of Tornado Research in Oklahoma," Chronicles of Oklahoma 94 (Spring 2016), 4-31. Heavily ... The winds of the tornado vortex and of constituent turbulent eddies, as well as airflow interaction with the surface and debris ... That begins when increasing rainfall drags with it an area of quickly descending air known as the rear flank downdraft (RFD). ... This downdraft accelerates as it approaches the ground, and drags the supercell's rotating mesocyclone towards the ground with ...
"Infection and Drug Resistance. 8: 119-128. doi:10.2147/IDR.S66739. PMC 4440423. PMID 26028977.. ... Overzier E, Pfister K, Herb I, Mahling M, Böck G, Silaghi C (June 2013). "Detection of tick-borne pathogens in roe deer ( ... Host Interaction and Pathogenesis. Caister Academic Press. ISBN 978-1-904455-58-5. .. ... A hexavalent (OspA) protein subunit-based vaccine candidate VLA15 was granted fast track designation by the U.S. Food and Drug ...
... a drug user, possibly a drug seller, and married to an angry, ungrateful black woman.[30] Obama was accused of dog-whistling to ... Herbert, Bob (October 6, 2005), "Impossible, Ridiculous, Repugnant", The New York Times, retrieved February 5, 2016. ...
Jeroen Heijmans, Bill Mallon) lists three further records after Dodds but before Herbert Cortis. Listed only by surname, 1877, ... which reduces the aerodynamic drag.[26] ... Interaction. *Help. *About Wikipedia. *Community portal. * ...
John Herbert, the governor of Bengal, issued an urgent directive in late March 1942 requiring stocks of paddy (unmilled rice) ... People would tie a rope around the necks and drag them over to a ditch."[249] Corpses were stacked along the streets of ... but holds that famine is primarily the interaction between pre-existing "structural vulnerability" (such as poverty) and a ... Contemporaries attested that Herbert cared about the starvation in Bengal; so prioritising the war effort may reflect his and ...
About the time Taylorism arose, Hartness reconsidered worker-machine interaction and its impact on worker psychology.[11] The ... Herbert A. Simon (1916-2001). *David McClelland (1917-1998). *Leon Festinger (1919-1989) ... Is the effect of job strain on myocardial infarction risk due to interaction between high psychological demands and low ...
This is from its preference of dried herbs and plant material sometimes used as drugs; e.g. drugstore beetles have been known ...
... he was told by the Great Spirit where to find special mushrooms that would give him the strength to drag the whale back to the ... Interaction with humans. Whaling. Main articles: Whaling and History of whaling. Whale Fishing: Woodcut by Thevet, Paris, 1574 ...
By 2002, the 'herb' was valued at R 105,000 ($1,435) per kilogram, allowing the government to charge a royalty of R 20,000 ($ ... Cordyceps information from *Cordyceps sinensis (Berk.) Sacc. Medicinal Plant Images Database (School of Chinese ...
Herbert James Paton (1971). "§2 Moral judgements are a priori". The Categorical Imperative: A Study in Kant's Moral Philosophy ... The first group, wanton addicts, have no second-order desire not to take the drug. The second group, "unwilling addicts", have ... Stemming from Cartesian dualism, a formulation sometimes called interactionalist dualism suggests a two-way interaction, that ... The members of the second group freely desire not to take the drug, but their will is overcome by the addiction. Finally, the ...
" 3 January 2018. Retrieved 5 January 2018.. *^ O'Toole, S.; Mullan, F. (2018). "The role of the diet in tooth wear" ( ... It also includes more obscure herbs, like mugwort, rue, pennyroyal, wild carrot, blue cohosh, tansy, and savin.[medical ... Ayurvedic tea is made of Ayurvedic herbs like Agya Ghas, Yeshtimadhu, Tulasi etc. Various pharmacies have come up with their ... While varieties of herbal teas are defined as any plant material for infusion, below is a list of common herbs: *Anise tea, ...
Herbert Marcuse criticized Being and Nothingness for projecting anxiety and meaninglessness onto the nature of existence itself ... Psychedelic drug advocates. *Scholars of antisemitism. *World War II prisoners of war held by Germany ... Marcuse, Herbert. "Sartre's Existentialism". Printed in Studies in Critical Philosophy. Translated by Joris De Bres. London: ...
Bennett Alan Weinberg; Bonnie K. Bealer (2001). The World of Caffeine: The Science and Culture of the World's Most Popular Drug ... Hayes, Elizabeth S. (1980). Spices and Herbs: Lore and Cookery. Courier Dover Publications. p. 74. ISBN 0-486-24026-6.. ... Bennett Alan Weinberg, Bonnie K. Bealer (2001). The World of Caffeine: The Science and Culture of the World's Most Popular Drug ... Lovell, Julia (2012). The Opium War: Drugs, Dreams and the Making of China. Picador. ISBN 978-1-4472-0410-7.. ...
"Parsley information on".. *^ Jett, J. W. That Devilish Parsley Archived 2007-06-26 at the Wayback Machine West ... The two main groups of parsley used as herbs are French, or curly leaf (P. crispum crispum group; syn. P. crispum var. crispum ... In southern and central Europe, parsley is part of bouquet garni, a bundle of fresh herbs used as an ingredient in stocks, ... Garden parsley is a bright green, biennial plant in temperate climates, or an annual herb in subtropical and tropical areas. ...
... of Nigeria's imported antimalarial drugs were fake.[19] Nigeria is Africa's largest drugs market, and over 70% of its drugs are ... or dried herbs such as oregano are sold as cannabis, to cases where the active ingredients are "cut" with a diluent (as in ... The diluents used often depend on the way drug purchasers consume particular drugs. Drug dealers selling heroin to users who ... Counterfeit drugs have even been known to have been involved in clinical drug trials.[citation needed] ...
a b Coghlan, Herbert Henery. (1977). Notes on prehistoric and early iron in the Old World. Oxprint. pp. 99-100 ... It is the interaction of the allotropes of iron with the alloying elements, primarily carbon, that gives steel and cast iron ...
"Systematic overview of warfarin and its drug and food interactions". Arch. Intern. Med. 165 (10): 1095-106. doi:10.1001/ ... Donaldson, Henry Herbert. (1915) The Rat. pp. 13. *^ Friends' Intelligencer. (1858) Volume 14. William W. Moore, publisher. pp ... Christie, D.; Herbert, D. J.; Cooper, A. P. R.; Poncet, S.; Cook, A. J. (June 2010). "Glacier retreat on South Georgia and ... Warfarin is an anticoagulant that was approved as a drug for human use in 1954 and is much safer to use near humans and other ...
"Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review". Journal of Food and Drug ... Helgi Öpik; Stephen A. Rolfe; Arthur John Willis; Herbert Edward Street (2005). The physiology of flowering plants. Cambridge ... The latter is called the "grapefruit juice effect", a common name for a related group of grapefruit-drug interactions.[46] ... "Journal of Food and Drug Analysis. 25 (1): 71-83. doi:10.1016/j.jfda.2016.11.008. ISSN 1021-9498. PMID 28911545.. [permanent ...
Stefanie Schwartz (9 January 2008). Psychoactive Herbs in Veterinary Behavior Medicine. John Wiley & Sons. pp. 139-. ISBN 978-0 ... Hui KM, Wang XH, Xue H (2000). "Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site ... Current Drug Targets. 5 (2): 177-84. doi:10.2174/1568006043586206. PMID 15853750.. ... Today it is still a popular medicinal herb.[11] It is widely available as a commercial product used in western herbalism to ...
" Retrieved 23 July 2016.. *^ Capuano, Rhomas M. (2005). "Las huellas de otro texto médico en Don Quijote: Las ... Rosmarinus officinalis, commonly known as rosemary, is a woody, perennial herb with fragrant, evergreen, needle-like leaves and ... It is a member of the mint family Lamiaceae, which includes many other herbs. The name "rosemary" derives from the Latin for " ... "A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, ...
7.^ Stockley, IH (2002), Stockley's Drug Interactions. 6th ed. London: Pharmaceutical Press. ... "Adaptogens: Herbs for Strength, Stamina, and Stress Relief," Healing Arts Press, 2007 ...
"US Food and Drug Administration. Retrieved 30 December 2011.. *^ "21 U.S.C. § 188 : US Code - Section 188 TO 188N: Repealed. ... Papaver somniferum is an annual herb growing to about 100 cm (39 in) tall. The plant is strongly glaucous, giving a greyish- ... create vital drugs and combat poverty and the diversion of illegal opium to drug traffickers and terrorist elements. Senlis is ... The extent to which false information is spread in forums relating to recreational drug use and/or drug use relating to self- ...
In addition, drugs may be developed that activate autocrine signaling in cancer cells that would not otherwise occur. For ... Herbert Kim (2011). "HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That is Critical for ... for therapeutic intervention by means of Wnt antagonists or other molecules that interfere with ligand-receptor interactions of ... In the case of PDGFR signalling, overexpression of a dominant-negative PDGFR or application of the cancer drug STI571 are both ...
This condition can also be treated with drugs that increase dopamine, such as oxytocin, along with other drugs. In general, it ... Schaumburg, Herbert; Kaplan, Jerry; Windebank, Anthony; Vick, Nicholas; Rasmus, Stephen; Pleasure, David; Brown, Mark J. (1983 ... Other drugs which may be helpful in the treatment of this condition include dopamine agonists, oxytocin, phosphodiesterase type ... Additionally, it is thought that depression, drug addiction, high levels of prolactin, low testosterone, and uses of certain ...
... are any arrangement under which wages are paid in the form of: payment in kind (i.e. commodities, including goods and/or services); credit with retailers or; a money substitute, such as scrip, chits, vouchers or tokens, rather than with conventional money. Truck, in this context, is an archaic English language word meaning "exchange" or "barter" (and is derived from the French troquer). By contrast, the term truck system usually refers to a specific set of practices under which employees are defrauded and/or exploited. This may take one or both of two forms. Firstly, the payment in kind, credit, or money substitute is demonstrably of a lesser market value than the amount of money that would normally be paid for the same work. Secondly, truck systems are normally regarded as undesirable or illegal because they limit employees' ability to choose how to spend their earnings. For example, credit or company scrip might be usable only for the purchase of goods at a monopolistic ...
Search: Cimicifuga[Majr] AND "Herb-Drug Interactions"[Mesh] *. Format. Summary. Summary (text). Abstract. Abstract (text). ...
Herbs including ginkgo biloba, ginseng, ginger, echinacea, St. Johns Wort, garlic, and more. ... Information about herbs and the possible toxic side effects and drug interaction information. ... of various herbs with particular focus on potential herb-drug interactions.. Keep in mind that the information in the Uses ... Ginkgo Biloba drug interactions. *Uses: This herb is very popular as a treatment for dementia (a progressive brain dysfunction ...
The American Academy of Family Physicians has published a summary of some of the potential risks of interaction between certain ... interactions between drugs, herbs, and other dietary supplements. Here are four highlights of that article: To continue reading ...
Search: "Ginkgo biloba"[Majr] AND "Herb-Drug Interactions"[Mesh] *. Format. Summary. Summary (text). Abstract. Abstract (text) ... Effects of Ginkgo biloba extract on anticoagulation and blood drug level of warfarin in healthy wolunteers]. ... Drug Metab Dispos. 2010 Feb;38(2):270-5. doi: 10.1124/dmd.109.030080. Epub 2009 Nov 4. ... Risk of hemorrhage associated with co-prescriptions for Ginkgo biloba and antiplatelet or anticoagulant drugs. ...
The majority of cancer patients use complementary therapies such as herbs and dietary supplements. Although figures differ, ... Common cancer therapies that may be made more or less effective or toxic due to an herb-drug interaction include tyrosine ... details potential negative interactions between herbs (dietary supplements) and some of the drugs used in cancer treatment. ... he outlines the common mechanisms underlying risks for interactions. Various herbs can affect drug absorption and metabolism, ...
... Feng Chen,1 Li Li,2 and Dan- ... Consideration of Herb-Drug Interactions," BioMed Research International, vol. 2017, Article ID 9868694, 12 pages, 2017. https ... 1Hainan Provincial Key Laboratory of R&D of Tropical Herbs, School of Pharmacy, Hainan Medical College, Haikou 571199, China. 2 ... State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ...
... we describe the mechanisms via which interactions between herbs and prescription drugs may occur, and highlight four popular ... herbs and a medicinal mushroom commonly used by cancer patients, along with reports of their interactions with standard drugs. ... Herb-Drug Interactions. Herb-drug interactions started appearing in the literature in the 1980s, when reports described the ... The basic mechanisms of herb-drug interactions are similar to other drug interactions. They can be divided into ...
Learn about grapefruit and other common drug interactions to medications like warfarin, tramadol, Zoloft, trazodone, gabapentin ... drugs, and herbal supplements interact with your pharmaceuticals? ... "Antiepileptic Drug Interactions - Principles and Clinical Implications.". *FDA: "Avoid Food-Drug Interactions," "Avoiding Drug ... Ask about potential interactions with other drugs and possible interactions with foods, herbs, and supplements. Meds need to be ...
Learn about grapefruit and other common drug interactions to medications like warfarin, tramadol, Zoloft, trazodone, gabapentin ... drugs, and herbal supplements interact with your pharmaceuticals? ... Drug Interactions: Foods, Drugs, Herbs Affecting Medications. Reviewed By Charles Patrick Davis, MD, PhD on 9/21/2017 ... "Antiepileptic Drug Interactions - Principles and Clinical Implications.". *FDA: "Avoid Food-Drug Interactions," "Avoiding Drug ...
... and supplements youre taking could interact with prescription drugs? Youre not alone. Nearly every day, someone ... Herb-Nutrient- Drug Interactions to be aware of….. Herb, nutrient, drug interactions are rare but can happen. A new 2004 review ... Heres what you need to know about drug-herb-nutrient interactions:. Investigating how herbs and nutrients interact with drugs ... a theorized interaction often never occurs or is neutralized. In some cases, a drug-herb interaction occurs because an herb is ...
Some side effects can happen when you have a drug and herb interaction. This is important to keep in mind when taking ... Drug and herb interaction. It must be kept in mind that herbs are powerful, and in some instances there may be a drug and herb ... Below, we have compiled a very small list of herbs and drugs that may interact, but visitors must please note that it is not an ... We have information on individual herbs that you can access by clicking here, and if you wish to look at our product list, ...
Prior to the development of highly effective anti-HIV drug combinations, thousands of HIV infected people tried a variety of ... Reports were formally published in 2000 that a very popular herb, St. Johns Wort, ... The news about herb-drug interactions triggered a retreat from reliance on this herb, a change that was intensified when some ... A difficulty with detecting actual herb-drug interactions is the complexity of individual cases where the interaction may occur ...
... mechanisms involved in herb-drug interactions, and how new technologies in supplements and drugs may impact herb-drug ... Describe how new technologies in supplements and drugs may impact herb-drug interaction. ... Free online lecture -- Clinically Relevant Herb-Drug Interactions: Past, Present, and Future (NCCAM). Published: Tuesday, June ... Identify two types of mechanisms involved in herb-drug interactions and provide one example of each. ...
To understand the precise effects of herb-drug interactions in humans, both the herb and drug need to be studied together in a ... 3 In a systematic review of 890 pairs of herb-drug interactions,4 St. Johns wort was found to cause the majority of herb-drug ... In 2004, "Herb-drug Interaction" was introduced as a Medical Subject Headings (MeSH) term, defined as "The effect of herbs, ... Johns wort produced significant interactions with prescription drugs led to a surge of interest in the study of herb-drug ...
There are misconceptions that most herbs are natural and safe.1 It is not surprising, given this misconception of safety, ... 2 All herbs have actions that may interact with drugs patients may be taking. The risk of drug and herb interactions may be ... Drug and herb interactions. Searching the web. Volume 38, No.8, August 2009 Pages 627-633 ... A web portal, with risk categorisation of mild, moderate and severe for drug-herb interactions, can assist doctors in clinical ...
These include effects that often result in DRUG INTERACTIONS; FOOD-DRUG INTERACTIONS; and HERB-DRUG INTERACTIONS. ... Herb-drug Interactions. The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs. ... Older HIV-infected Adults and Drug Interactions: French Cross-sectional Study. Drug interactions between antiretroviral drugs ... Drug-drug Interactions Between Antiretroviral Drugs and Cardiovascular Drugs in Elderly Patients ...
All about The Essential Herb-Drug-Vitamin Interaction Guide: The Safe Way to Use Medications and Supplements Together by George ... drug interactions (2) Drug-herb interactions. (1) Drug-nutrient interactions (1) drugs (1) Food and Drug Interactions (1) herbs ... The Essential Herb-Drug-Vitamin Interaction Guide is organized alphabetically by herb, with an index of medications at the end ... you need to know how to use herbs and supplements safely and effectively. The Essential Herb-Drug-Vitamin Interaction Guide ...
Herb-drug interactions, Lancet, 2000; 355: 1019 1020.. 24. Blumenthal M, Interactions between herbs and conventional drugs: ... A well-reasoned analysis of the potential for drug-herb interaction will often permit the use of drugs and herbs together, but ... interactions with drugs. The drugs of most concern for interactions with herbs were those that people took continuously, such ... For the most part, the possibility of herb-drug interactions had been largely ignored during this revival of medicinal herb use ...
Chang, Although you only know me from a few live chat interactions from your elotus seminars... ... Creating Positive Herb & Drug Interactions. Creating Positive Herb & Drug Interactions. Robert Linde, AP ...
Knowledge of drug-herb interactions is limited and much more research needs to be done to further document clinically relevant ... interactions. Even though preclinical data are often poorly generalizable to the human situation, caution must be taken in the ... Clinically based evidence of drug-herb interactions: a systematic review Expert Opin Drug Saf. 2010 Jan;9(1):79-124. doi: ... Summary tables of relevant drug-herb interactions are presented both for the individual herbs included and at the level of the ...
Herb-Drug Interactions, Part 2 is by Prof. Liao for acupuncture ceu credit for acupuncture continuing education online. NCCAOM ... The interactions of Lower blood pressure drugs (antihypertensives) with raising the Qi and Yang herbs.. The interactions of ... The interactions of anti-estrogenic (used in the treatment of cancer) drugs with herbs that tonify Qi, Blood, Jing, and Kidney ... Herbs that warm the interior and strengthen Kidney Yang and Qi must be used with caution when patients take drugs that raise ...
The present study was to investigate the herb-drug interaction of Clopidogrel and XST by modulation of the pharmacodynamics and ... The CAMD pharmacodynamics and CES1A metabolism were investigated to evaluated the herb-drug interaction.,i, Results,/i,. ... The animal study indicated that clopidogrel and XST coadministration produced significant herb-drug interactions at active CAMD ... It also indicated that the bioactive components in XST had good interaction with the CES1A metabolism target by molecular ...
... April 26, 2017. allergies drug Herb reactions ... reactions and drug herb interactions with herbal supplements compared to medical drugs. • Still some idiosyncratic reactions ... Are there chances of side effects/allergies/reactions/drug herb interactions?. *How Do You Treat Swollen Lips And Other Bizarre ... We suggest you to contact us if you experience some side effects or reaction or interaction so that we can help you at the ...
... great possibility of herb-drug interaction. This study investigates the effect of herb drug interaction at molecular level and ... Interaction between herbal products and conventional drugs is one of the major safety concerns these days. Major herb drug ... Our present results suggest that herbal medical preparations such RC has potential for herb-drug interaction which is a major ... Cytochrome P 450 expression, herb-drug interaction, raloxifene, red clover, tamoxifen. Red clover (RC, Trifolium pratense L.) ...
Hu Z, Yang X, Ho PC, Chan SY, Heng PW, Chan E, Duan W, Koh HL, Zhou S. Herb-drug interactions: a literature review. Drugs 2005; ... The prescription of therapeutic drugs to these patients significantly contributes to herb-drug interactions at the ... monnieri to contribute to herb-drug interactions when orally co-administered with drugs metabolized by CYP1A2, CYP3A4, CYP2C9, ... The herb-drug interaction was reflected by the B. monnieri-mediated increased intestinal absorption and reduced first-pass ...
Recognize herb-drug interactions when using the Evergreen Herbs Collection formulas.. *Recognize pros and cons of ... shares the most appropriate herb-drug interactions in relation to Evergreen Herbs Collection formulas. In addition, Dr. Chen ... Unexpected side effects from herb-drug interactions are a real and often devastating possibility. Ensure the safety of your ... It is essential that acupuncturists understand the fundamentals of possible herb-drug interactions prior to prescribing any ...
Gil Bar-Sela (Israel) 39 min Themes: Palliative care; Safety (herb-drug interaction); Anthroposophic medicine38:50 ... Vinjar Fønnebø (Norway) 14 min Themes: Safety (herb-drug interaction); Medical systems (Europe); Integrative medicine13:48 ... Jun Mao (USA) 24 min Themes: The Integrative oncology consultation; Safety (herb-drug interaction)24:24 ... Vinjar Fønnebø (Norway) 14 min Themes: Safety (herb-drug interaction); Medical systems (Europe); Integrative medicine. ...
... were among the herbs most commonly involved in herb-drug interactions. Drugs with anticoagulant/antiplatelet activity (e.g. ... were among the herbs most commonly involved in herb-drug interactions. Drugs with anticoagulant/antiplatelet activity (e.g. ... warfarin, aspirin) were frequently implicated in herb-drug interactions, with documented interactions with over 30 herbs and ... warfarin, aspirin) were frequently implicated in herb-drug interactions, with documented interactions with over 30 herbs and ...
... and certain herbs and drug can also interact - causing unwanted drug herb interaction. Herbs can do wonders, but safety must be ... kept in mind at all times as herbs are powerful compounds. ... You should avoid some herbs in pregnancy and during lactation ( ... Herbs to avoid in pregnancy and lactating mothers. The constituents in herbs are powerful, and some herbs should be best ... Herbs - general safety and pregnancy. There seems to be a general misconception that because a pill or potion is made from ...
Herb-Drug Interaction between Echinacea purpurea and Darunavir-Ritonavir in HIV-Infected Patients José Moltó, Marta Valle, ... Herb-Drug Interaction between Echinacea purpurea and Darunavir-Ritonavir in HIV-Infected Patients ... Herb-Drug Interaction between Echinacea purpurea and Darunavir-Ritonavir in HIV-Infected Patients ... Herb-Drug Interaction between Echinacea purpurea and Darunavir-Ritonavir in HIV-Infected Patients ...
  • Various herbs can affect drug absorption and metabolism, for example, which can in turn increase or decrease the effectiveness and toxicity of various medicines. (
  • It was defined as "the effect of herbs, other plants, or plant extracts on the activity, metabolism, or toxicity of drugs. (
  • Studies of pharmacokinetics focus on the actions of microsomal enzymes of the cytochrome P450 (CYP) family and membrane transporters such as P-glycoprotein (P-gp), which play important roles in the absorption and metabolism of many prescription drugs. (
  • Aside from indinavir, the metabolism of other protease inhibitor anti-HIV drugs are also affected by St. John's Wort. (
  • Just as fruits other than grapefruit have minimal impact on drug metabolism, so too, herbs other than St. John's Wort appear to have limited effect. (
  • In 2004, "Herb-drug Interaction" was introduced as a Medical Subject Headings (MeSH) term, defined as "The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs. (
  • Studies conducted to date have focused on pharmacokinetics to determine the absorption, distribution, metabolism, and elimination of simultaneous use of herbal products and drugs. (
  • Therefore, it is likely that they interfere with the metabolism of substrate drugs. (
  • The action of a drug that may affect the activity, metabolism, or toxicity of another drug. (
  • The properties and processes of drug metabolism and drug interactions. (
  • Calitz C, Gouws C, Viljoen J, Steenekamp J, Wiesner L, Abay E, Hamman J. Herb-Drug Pharmacokinetic Interactions: Transport and Metabolism of Indinavir in the Presence of Selected Herbal Products. (
  • The present study was to investigate the herb-drug interaction of Clopidogrel and XST by modulation of the pharmacodynamics and liver Carboxylesterase 1A(CES1A) metabolism. (
  • The CAMD pharmacodynamics and CES1A metabolism were investigated to evaluated the herb-drug interaction. (
  • It also indicated that the bioactive components in XST had good interaction with the CES1A metabolism target by molecular simulation. (
  • Major herb drug interactions are metabolism-mediated and involve either induction or inhibition of cytochrome P 450 (CYP) enzymes which may affect the fate of conventional drugs in body. (
  • Herbal medicines are often perceived to be innocuous and healthier than manufactured medicines even though they can act on the metabolism of antiretroviral agents, decreasing or increasing drug concentrations through induction or inhibition of metabolic pathways ( 11 , 13 ). (
  • Transporter Certified™ human hepatocytes in sandwich-culture (SCHH) provide a fully integrated hepatic cell system that maintains drug clearance pathways (metabolism and transport) and key regulatory pathways (CAR/PXR) necessary for quantitative assessment of HDI potential. (
  • Thank you for sharing this Drug Metabolism & Disposition article. (
  • Message Body (Your Name) thought you would be interested in this article in Drug Metabolism & Disposition. (
  • The results suggest that cryopreserved human intestinal mucosa can be used for in vitro evaluation of drug interactions involving enteric drug metabolism. (
  • Pharmacodynamics concern the actions of two or more drugs and pharmacokinetics concern the absorption, distribution, metabolism, and/or excretion of one or more drugs affecting another. (
  • Drug interactions can be pharmacokinetic, in which the drugs potentiate each other, or pharmacodynamic, in which a drug affects the absorption, elimination, and/or metabolism of another drug. (
  • Metabolic drug-drug interactions occur when a drug inhibits or induces the activity of a drug-metabolising enzyme, which catalyses the metabolism of a concomitantly administered drug. (
  • From the drug metabolism perspective, one notable system involved in metabolic drug interactions is the enzyme system comprising the cytochrome P450 (CYP) monooxygenases. (
  • Current Drug Metabolism , 9, 581-91. (
  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. (
  • The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. (
  • Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. (
  • The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism. (
  • Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes. (
  • We describe the mechanisms via which these interactions may occur, as divided into pharmacokinetics and pharmacodynamics. (
  • Effects of sinapic acid on hepatic cytochrome P450 3A2, 2C11, and intestinal P-glycoprotein on the pharmacokinetics of oral carbamazepine in rats: Potential food/herb-drug interaction. (
  • Dietary supplements, herbal medicines, and other foods may affect the pharmacokinetics and/or pharmacodynamics of carbamazepine (CBZ), which may possibly lead to potential drug-drug/herb-drug interact. (
  • Ageing is characterized by physiological changes, which can impact drug pharmacokinetics and thereby cause drug-drug interactions. (
  • To evaluate the pharmacokinetics and adverse effects of medicinal herbs, as well as clinical evidence of herb-drug interactions. (
  • All literature collected pertained to adverse effects, pharmacokinetics, and suspected or confirmed cases of herb-drug interactions. (
  • Participants are familiarized with pharmacodynamics, pharmacokinetics, and also the additive, synergistic, and antagonistic interactions of herbs with drugs. (
  • Overall, the four herbs had limited interaction effect on CLZ pharmacokinetics in the acute and chronic treatment. (
  • A cause of a drug interaction involves one drug which alters the pharmacokinetics of another medical drug. (
  • In 2008, American Family Physician , the journal of the American Academy of Family Physicians, published an overview of interactions between drugs, herbs, and other dietary supplements. (
  • The majority of cancer patients use complementary therapies such as herbs and dietary supplements. (
  • In this Grand Rounds presentation, K. Simon Yeung, a pharmacy and botanicals specialist with Memorial Sloan Kettering's Integrative Medicine Service, details potential negative interactions between herbs (dietary supplements) and some of the drugs used in cancer treatment. (
  • We conclude by emphasizing the need to inform patients and physicians about herb-drug interactions and how to advise patients on appropriate use of herbal supplements to minimize the risk for interactions. (
  • Below, we have compiled a very small list of herbs and drugs that may interact, but visitors must please note that it is not an exhaustive list, and that they at all times, when taking medication and supplements , in whatever type or form, must discuss it with your health practitioner should they have any side effect. (
  • Iron supplements interact with a long list of drugs used to treat a variety of conditions. (
  • During that time, none of the herbs had been shown to be substantially effective for inhibiting HIV, but many people were convinced that they helped, some to the point that they considered herbal supplements to be life-saving. (
  • Do you worry that the herbal remedies, high potency vitamins, and supplements you"re taking could interact with prescription drugs? (
  • As the lines blur between supplements, natural remedies and drugs, the answers aren't simple. (
  • In many cases, herbs and supplements can be used supportively, to maintain health while a person is on drug therapy. (
  • Ultimately, the decision to use herbal supplements while on prescription drug therapy is a personal one, and one I recommend you make with your physican's counsel. (
  • The lecture identifies factors that contribute to the risk for herb-drug interactions, mechanisms involved in herb-drug interactions, and how new technologies in supplements and drugs may impact herb-drug interaction. (
  • Describe how new technologies in supplements and drugs may impact herb-drug interaction. (
  • The Integrative Medicine Service at Memorial Sloan-Kettering Cancer Center developed and maintains a free website-About Herbs ( provides objective and unbiased information about herbs, vitamins, minerals, and other dietary supplements, and unproved anticancer treatments. (
  • The Essential Herb-Drug-Vitamin Interaction Guide: The Safe Way to Use Medications and Supplements Together by George T. Grossberg M.D. (
  • If you're one of the 60 million herb, vitamin, and supplement users in America, you need to know how to use herbs and supplements safely and effectively. (
  • The Essential Herb-Drug-Vitamin Interaction Guide profiles 300 supplements and gives vital information regarding potentially dangerous interactions, possible side effects, and typical dosages. (
  • There are very little chances of side effects, allergies, reactions and drug herb interactions with herbal supplements compared to medical drugs. (
  • As herbal products (and dietary supplements in general) continue to grow in popularity, patients and health care providers should be vigilant of potential herb-drug interactions. (
  • Patients may be putting themselves at risk for toxicity and drug interactions with the expanding use of herbal medications, OTCs, and dietary supplements. (
  • It is important to take a thorough medication history that includes dietary habits, OTCs, supplements, and herbal remedies to predict and prevent potential interactions. (
  • Combining pharmaceuticals with herbs or supplements may complement or interfere with a drug's therapeutic action or may increase adverse effects. (
  • Commercial formulations of 29 commonly used herbal supplements (HSs) and grapefruit juice were evaluated for drug interaction potential via quantification of their CYP3A inhibitory potential in two in vitro experimental models of human small intestine, cryopreserved human intestinal mucosa (CHIM), and cryopreserved human enterocytes (CHEs). (
  • The results illustrate that CHIM and CHE represent physiologically relevant in vitro experimental models for the evaluation of drug interaction potential of herbal supplements. (
  • SIGNIFICANCE STATEMENT In vitro evaluation of 29 popular herbal supplements in cryopreserved human intestinal mucosa identified green tea extract, horehound, St. John's wort, and valerian root to have CYP3A inhibitory potential similar to that for grapefruit juice, suggesting their potential to have clinically significant pharmacokinetic interaction with orally administered drugs that are CYP3A substrates. (
  • Now you can have instant access to the evidence-based information and evaluation of herbs and nutritional supplements you've been waiting for and your patients have been asking for. (
  • Many of your patients are using nutritional supplements and herbs, either on their own initiative or as part of professional care. (
  • Thorough, accurate, evidence-based information that all practitioners need if they or their patients use herbs or dietary supplements. (
  • Half of patients are regularly using vitamins, minerals, herbs and other supplements. (
  • Coadministering herbs, nutrients or supplements with pharmaceuticals may complement or interfere with a drug's therapeutic action, influencing potential adverse effects in specific clinical settings. (
  • Seventy comprehensive monographs cover the herbs, nutrients and supplements most commonly encountered in clinical practice. (
  • It seems common that over-the-counter products, vitamins, and herbal supplements are excluded from what patients typically think of as drugs [ 2 - 4 ], therefore it is important for physicians and pharmacists to investigate a complete medication history including all the drugs, herbals, vitamins and supplements. (
  • Many documented interactions are from limited and small case reports and clinical observations and the details around the interactions are sparse, however they support that some herbal medications or supplements have potentially harmful side effects as well as adverse interactions with conventional drugs. (
  • Adverse events associated with interactions with dietary and herbal supplements among inpatients. (
  • Intestinal and Hepatocellular Transporters: Therapeutic Effects and Drug Interactions of Herbal Supplements. (
  • Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements. (
  • Patients with cancer frequently use herbal or nutrient supplements and/or concomitant medications with their treatment, and therefore have a risk of herb-drug (HDI) or drug-drug interactions (DDIs) that could affect their outcomes. (
  • Some oncologists have proposed that herbs and nutritional supplements with antioxidant properties aimed at protecting normal cells from the harmful effects of cancer therapies might also protect cancer cells from the intended damage from radiation therapy, thereby countering the medical intervention. (
  • Martindale's pharmacology center: drugs, herbs, vitamins, Prescription & over-the-counter drug databases dietary, herbal & vitamin supplements medicinal plants & drug formulary. (
  • Herb-drug interactions demonstrated through clinical trials, pharmacokinetic studies, or documented case reports involving specific herbs (supplements) and drugs are usually clinically significant. (
  • But did you know that it's equally important to consider the potential interactions between your medications and herbal supplements? (
  • Herbal supplements can also increase your risk of experiencing drug side effects. (
  • As the lines blur between supplements, natural remedies and drugs, the answers aren''t simple. (
  • To avoid this interaction these antibiotics should be taken at least 2 hours before, or 4 to 6 hours after, magnesium supplements. (
  • Interaction however is not limited to drugs but includes also other supplements that patients may be taking at the same time including vitamins, minerals, food supplements and herbal remedies. (
  • Polypharmacy is common among older adults, with increasing numbers also using prescription drugs with herbal medicinal products (HMPs) and dietary supplements. (
  • There is no reliable evidence from the UK on concurrent use of HMPs and dietary supplements with prescription drugs in older adults. (
  • To establish prevalence of concurrent prescription drugs, HMPs, and dietary supplements among UK community-dwelling older adults and identify potential interactions. (
  • The majority of concurrent users (78.0%) used dietary supplements with prescription drugs. (
  • The most commonly used dietary supplements were cod liver oil, glucosamine, multivitamins, and vitamin D. Others (20.0%) used only HMPs with prescription drugs. (
  • We also discuss natural options that may reduce side effects of standard cancer therapies, as well as possible interactions between herbs and supplements and drugs. (
  • Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. (
  • Caution is advised in people taking drugs, herbs, or supplements that lower blood pressure. (
  • Caution is advised in people with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. (
  • Herbs and Natural Supplements: Volume 1, An Evidence-Based Guide by Braun, 9780729541718. (
  • To help ensure the safe use of herbal supplements and prevent drug interactions, the American Herbal Products Association (AHPA) produced the Botanical Safety Handbook to summarize the latest research on the safety of more than 500 species of herbs. (
  • The leading trade associations of the dietary supplement industry support the responsible marketing and use of health-promoting vitamins, minerals, herbs, sports nutrition, and other dietary supplements. (
  • 4 Complementary and Alternative Medicine Practices b ~40% of the US population uses dietary supplements often b ~ 50% of people have used herbals b ~ 4% rely exclusively on alternatives b In Germany over 700 herbs are available and prescribed by 70% of physicians NEJM 1993;328:246-52. (
  • Over a third (36%) of the elderly in the U.S. regularly use five or more medications or supplements, and 15% are at risk of a significant drug-drug interaction. (
  • In contrast to conventional medications, unconventional treatments (such as herbs) have little or no actual scientific basis so doctors can guide their patients regarding proper usage or potential toxicity. (
  • Moreover, even if a given herb has a known toxicity, the manufacturer may or may not warn consumers. (
  • Some herbs were reported to interact with others in a beneficial way, such as by reducing the toxicity or other adverse effects that might be experienced (see Table 1). (
  • Xiangsha (detoxification) or Xiangwei (inhibition): one drug reduces the toxicity or side effects of another. (
  • Herbal toxicity and herb-drug interactions have not surfaced as a major issue in the USA partially because the list of FDA allowable herbs is highly restricted such that most available herbs do not have harmful reactions with pharmaceuticals. (
  • These interactions can increase toxicity or reduce the therapeutic benefit. (
  • Prevent use with the herb licorice root (this is the herb and not the sweet), as its diuretic result can lead to low potassium levels and toxicity. (
  • in this case, some strengthening herbs and herbs that moderate the toxicity of ephedra could have been used in a formula. (
  • Foods and botanicals that commonly interact with cancer drugs include grapefruit juice, St. John's wort, ginkgo, and kava kava. (
  • In this article, we describe the mechanisms via which interactions between herbs and prescription drugs may occur, and highlight four popular herbs and a medicinal mushroom commonly used by cancer patients, along with reports of their interactions with standard drugs. (
  • We highlight four popular herbs and a medicinal mushroom commonly used by cancer patients-turmeric, green tea, ginger, ashwagandha, and reishi mushroom-along with reports of their interactions with standard drugs. (
  • Another compound, hyperforin, is a major constituent of St. John's wort, an herb commonly used to treat depression. (
  • Fortunately, it appears that few other commonly used herb materials have such a dramatic effect. (
  • Even though people often think of herbs as plants or plant-derived materials, several commonly used items were obtained from animals and minerals. (
  • Bacopa monnieri, a perennial herb, belongs to the family, Scrophulariaceae and is commonly known as Brahmi in the Ayurvedic system of medicine. (
  • Interestingly, herbs beginning with the letter "g" (garlic, ginger, ginkgo, and grapefruit) were among the herbs most commonly involved in herb-drug interactions. (
  • - Presenting detailed, evidence-based coverage of the most commonly encountered therapeutic agents in modern clinical practice, this resource is designed to help you safely and effectively integrate herbal, nutrient, and drug therapy for your patients or clients. (
  • More than 60 comprehensive monographs of herb-drug and nutrient-drug interactions cover the most commonly used herbs and nutrients in health-related practice and help you coordinate safe, reliable therapy. (
  • Commonly, the issue is to what extent and which herbs may decrease or increase the efficacy of warfarin. (
  • Allergy drugs suppress allergic reactions and often have an astringent property whereas acrid and warm herbs commonly used in the treatment of allergies open the pores and release the wind. (
  • Herb, Nutrient and Drug Interactions provides detailed, evidence-informed coverage of the most commonly encountered therapeutic agents in modern clinical practice. (
  • The most commonly used herbs were sage, anise and peppermint. (
  • Systemic exposure to some commonly used drugs including oseltamivir, irinotecan, and clopidogrel were changed when they were co-administered with herb products such as goldenseal, black cohosh, ginger, St. John's Wort, curcumin, and some Chinese compound formula in animals. (
  • WHO estimates that eighty percent of the world's population uses some form of herbal medicine for some aspect of their primary healthcare and about one-forth of all conventional medicines including roughly 120 of the most commonly prescribed drugs contain some ingredient derived from plants. (
  • Pharmacokinetic and/or pharmacodynamic interactions of five commonly used herbal remedies (danshen, garlic, Ginkgo biloba, ginseng, and St John's wort) with these drugs are presented, with focus of discussion being the potentials for interaction, their mechanisms and clinical implications. (
  • In addition to the usual questions regarding use of alcohol, tobacco, and illicit drugs, clinicians should inquire about the use of substances which are commonly used in certain areas and can present potential legal or health consequences (e.g., betel nut, commonly used in Thailand and Malaysia, sheesha/argileh, commonly used in the Middle East, and khat, commonly used in East Africa and the Arabian Peninsula) [ 5 - 8 ]. (
  • Herbs were also commonly used in the traditional medicine of ancient India, where the principal treatment for diseases was diet. (
  • Herb-drug interactions started appearing in the literature in the 1980s, when reports described the interactions of St. John's wort and grapefruit juice with several prescription drugs. (
  • What did come as a surprise was news-emerging first in 1999 and formally published in 2000-that a very popular herb, St. John's Wort, appeared to lower indinavir blood levels significantly. (
  • The growth in popularity of St. John's Wort had been driven by a number of published controlled clinical studies of its effectiveness as an antidepressant beginning in 1993, and it rapidly became one of the top selling herbs. (
  • St. John's Wort induces production of the enzyme, hence the drugs are degraded faster. (
  • Both St. John's Wort and grapefruit juice are among the strongest of the known natural substances that affect drug levels when consumed at ordinary doses. (
  • In addition to CYP3A4, St. John's Wort affects phosphorylated glycoprotein (P-glycoprotein or Pgp), which also metabolizes drugs. (
  • The discovery that both grapefruit juice and St. John's wort produced significant interactions with prescription drugs led to a surge of interest in the study of herb-drug interactions. (
  • 3 In a systematic review of 890 pairs of herb-drug interactions, 4 St. John's wort was found to cause the majority of herb-drug interactions (147), followed by ginkgo (51) and kava kava (41). (
  • For an anticancer drug such as lapatinib (Tykerb), which is a major CYP3A4 substrate, dose adjustment may be required when used together with an herb that is a strong CYP3A4 inducer (eg, St. John's wort) or CYP3A4 inhibitor (eg, horse chestnut). (
  • The most widely recognized botanical supplement associated with CYP450-mediated herb-drug interaction is St. John's wort ( Hypericum perforatum ). (
  • Pharmacokinetic interactions of drugs with St John's wort. (
  • Based on the results, green tea extract, horehound, St. John's wort, and valerian root may cause drug interactions with orally administered drugs that are CYP3A substrates, as was observed for grapefruit juice. (
  • Common herbal medicines that interact with drugs include St John's wort (Hypericum perforatum), ginkgo (Ginkgo biloba), ginger (Zingiber officinale), ginseng (Panax ginseng), and garlic (Allium sativum). (
  • An update on clinical drug interactions with the herbal antidepressant St. John's wort. (
  • Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea. (
  • Clinical drugs that interact with St. John's wort and implication in drug development. (
  • Molecular mechanisms underlying St. John's wort drug interactions. (
  • Dr Harnett cited St John's Wort ( Hypericum perforatum ), which is used for mild to moderate depression, as a well-known example of an herb that induces the CYP3A4 enzyme, "resulting in a reduction of serum levels of a number of medications that share this metabolic pathway, including chemotherapeutic agents. (
  • Interactions of St. John's Wort preparations with several drugs such as cyclosporin, oral contraceptives or anticoagulants have been thoroughly investigated since the 1990ies. (
  • This herb should be avoided in combination with other medications that can affect sun sensitivity such as tetracycline /Achromycin, sulfa- containing medications, piroxicam ( Feldene ). (
  • Herbs, however, contain biologically active compounds and can potentially interact with prescription medications, including chemotherapy drugs. (
  • Medications can interact with other medications, both prescription and over-the-counter, but did you know that drugs can interact with foods, beverages, and herbs, too? (
  • Make sure your doctor and pharmacist know all of the medications and herbs you are taking. (
  • B-complex vitamins are widely known to reduce drug-induced nutrient depletion from medications like oral contraceptives, estrogen replacement drugs, and methotrexate. (
  • A new 2004 review published in Archives of Internal Medicine shows that in 94 percent of cases, these interactions are fortunately, not serious.The following list is a good sampling of the known negative interactions between the herbs, nutrients, and prescription medications you may be taking. (
  • The risk of drug and herb interactions may be especially severe for the elderly, frail or those taking multiple medications for chronic diseases. (
  • Written by a leading authority in the field and a veteran health writer, The Essential Herb-Drug-Vitamin Interaction Guide is organized alphabetically by herb, with an index of medications at the end of the book so you can instantly locate the information you need, Comprehensive, thoroughly researched, and easy to use, this is one health guide you can't afford to be without. (
  • Alternately, herbs are helpful to assist the functions of the medications. (
  • If medications fail to bring blood pressure up to a normal range and are unable to strengthen the contractility of the heart, these herbs will help to restore balance, lift the blood pressure and strengthen contractility. (
  • Results of an extensive review demonstrated that use of herbal products by patients taking prescription or OTC medications (e.g., warfarin, statins, immunosuppressants, NSAIDs) resulted in adverse drug reactions, highlighting the need for patients to be educated on the potential for interactions to occur with these products. (
  • It is essential that acupuncturists understand the fundamentals of possible herb-drug interactions prior to prescribing any herbal formulas for patients who are already taking western medications. (
  • Is there any safe way to use Chinese herbs/formulas to wean off of STATIN medications, or would this be literally taking a shot in the dark? (
  • When patients consume western medications with herbs, care must be taken not to alter the effects of the western medicine such that adverse reactions occur. (
  • Often when patients are asked about their medications, they report only the prescription drugs that they take. (
  • Astragalus does have some drug interactions and should be used with caution or not be taken with certain groups of medications, including blood thinners, diuretics, antivirals, diabetic medicines, or high blood pressure medications. (
  • Both whole licorice and deglycyrrhizinated licorice interfere with many other medications, including diuretics, diabetes drugs, MAO inhibitors and corticosteroids. (
  • There is an increased risk of bleeding associated with the conjunctive use of licorice and pain relievers, high-blood pressure and blood-thinning medications and drugs used to treat heart conditions, such as digoxin, amiodarone and erythromycin. (
  • But the development of that drug was unusual, in that it came out of the compassionate usage of CBD to treat children with grave seizure disorders who were not responding to available medications. (
  • You probably know that before filling a prescription, you should make sure your doctor and pharmacist know about all the other medications you're taking to avoid potential interactions that can change how your medications work. (
  • Likewise, it's important to ask a health professional about potential interactions with your existing medications before buying a new herbal supplement. (
  • A questionnaire asking about prescription medications, HMPs, and sociodemographic information was posted to 400 older adults aged ≥65 years, identified as taking ≥1 prescription drug. (
  • Slippery elm could theoretically slow down or decrease absorption of other oral medications due to hydrocolloidal fibers, although there is a lack of actual interactions reported. (
  • In addition, 5-HTP may interact with medications or herbs that also affect serotonin levels, or cause certain lab test results to be inaccurate. (
  • b Identify the most common drug interactions with alternative medications. (
  • Participants review herb-drug interactions including contraindications, cautions, and benefits of using herbal medicine when patients are taking prescription drugs. (
  • In our health care tasks in the area of community pharmacy, the ESCOP monographs are extremely useful as a source of valuable and contrasted information, which allows us to resolve doubts about the dosage of plant products, as well as about interactions, contraindications or uses in special situations. (
  • After addressing the history and prevalence of herbal and dietary supplement use among cancer patients in the United States, he outlines the common mechanisms underlying risks for interactions. (
  • An overview of herb and dietary supplement efficacy, safety and government regulations in the United States with suggested improvements. (
  • Incidence and severity of potential drug-dietary supplement interactions in primary care patients: an exploratory study of 2 outpatient practices. (
  • Nearly four of five new dietary ingredient (NDI) notifications recently submitted to the Food and Drug Administration (FDA) had technical issues that prevented FDA from being able to determine safety, according to AHPA's NDI Database. (
  • Memorial Sloan Kettering's AboutHerbs website and its smartphone mobile app are additional resources for learning more about specific agents and their potential interactions with cancer medicines. (
  • This article looks at current internet resources that can assist GPs to answer patient questions about interactions between prescribed and complementary medicines. (
  • 1 It is not surprising, given this misconception of safety, that potentially up to billions of dollars are spent by patients on complementary medicines (CM). 2 All herbs have actions that may interact with drugs patients may be taking. (
  • Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. (
  • Most of those early medicines are described under the broad heading herbs, although that term may prove misleading. (
  • This could be considered the genesis of cautions about drug interactions (using the term drug here for medicines in general). (
  • Interactions between botanical medicines and synthetic drugs can be clinically relevant and it is important to understand what kinds of interactions are possible. (
  • Herbal medicines are often used in combination with conventional drugs, and this may give rise to the potential of harmful herb-drug interactions. (
  • Herbal medicines may interact with drugs at the intestine, liver, kidneys, and targets of action. (
  • Drugs means Rx or Over-the-counter Western Pharma allopathic medicines. (
  • later chemists began making their own versions of plant compounds thus herbal medicines declined in favor of drugs. (
  • This field is bringing forward new lead drug discoveries as well as safe and efficacious plant-based medicines. (
  • Because these herbal preparations share the same metabolic and transport proteins with prescribed medicines, the potential for a drug-herb interaction is substantial and is an issue of significant concern. (
  • Therefore, understanding the mechanisms of interaction is crucial in predicting the clinical effects. (
  • The basic mechanisms of herb-drug interactions are similar to other drug interactions. (
  • Identify two types of mechanisms involved in herb-drug interactions and provide one example of each. (
  • Understanding the mechanisms may help predict interactions that result in harmful effects. (
  • The underlying mechanisms for most reported herb-drug interactions are not fully understood, and pharmacokinetic and/or pharmacodynamic mechanisms are implicated in many of these interactions. (
  • The mechanisms by which drug interactions alter drug distribution include competition for plasma protein binding and displacement from tissue binding sites. (
  • Herb-drug interaction includes both pharmacokinetic and pharmacodynamic mechanisms. (
  • The proliferation of existing classifications at this level, along with the fact that the exact reaction mechanisms for many drugs are not well-understood means that it is almost impossible to offer a clear classification for these concepts. (
  • These changes are extraordinarily difficult to classify given the wide variety of modes of action that exist, and the fact that many drugs can cause their effect through a number of different mechanisms. (
  • Signal transduction mechanisms: these are molecular processes that commence after the interaction of the drug with the receptor. (
  • Investigating how herbs and nutrients interact with drugs is a new research area with few qualified experts. (
  • It's a detailed, complex subject that will eventually need millions of university grant dollars to determine which herbs and nutrients interact with which drugs. (
  • 1. Single herbs are more likely to interact with drugs. (
  • 2. Formulas are less likely to interact, and may even synergize with drugs for more effect with fewer side effects. (
  • Although we may not catch some of the exceptions (the unknown drug/formula interactions), there is a process for determining whether a drug is likely to interact with herbs in general. (
  • To treat anxiety There is limited evidence to suggest 5-HTP may be helpful for anxiety, but it may also interact with other drugs. (
  • These herbs interact with digoxin and increase the activity of digoxin in the body. (
  • Common cancer therapies that may be made more or less effective or toxic due to an herb-drug interaction include tyrosine kinase inhibitors, warfarin, tamoxifen, and immunosuppressants. (
  • The reports of indinavir interaction were soon accompanied by other reports suggesting that this herb interacted with a very wide range of drugs, from birth control pills to warfarin, with the same potential adverse consequence: lowering the drug dosage to an ineffective level. (
  • Warfarin (105) was identified as the drug most frequently involved, followed by insulin (41) and aspirin (36). (
  • Drugs with anticoagulant/antiplatelet activity (e.g. warfarin, aspirin) were frequently implicated in herb-drug interactions, with documented interactions with over 30 herbs and herbal products. (
  • Warfarin (Coumadin) is such a drug. (
  • The most common herb-drug interaction concern is that of warfarin (Coumadin). (
  • It should not be taken with other drugs that inhibit blood clots such as warfarin, non-steroidal anti-inflammatories (NSAIDs), and other blood thinners. (
  • Even though preclinical data are often poorly generalizable to the human situation, caution must be taken in the absence of clinical evidence especially where drugs with narrow therapeutic windows are concerned. (
  • The list below refers to taking these herbs at therapeutic levels , and not when used in moderation for culinary purposes in cooking or salads, but should you have any adverse effect while taking any herb, discontinue the use, and contact your health practitioner. (
  • If the Drug Handbook has a 'Reference Range' for the drug in question, that means that drug has a narrow therapeutic margin. (
  • InteractionsGuide™ is an innovative web-based application delivering access to the content of the landmark publication Herb, Nutrient and Drug Interactions: Clinical Implications and Therapeutic Strategies through a powerful suite of access, search and analysis functions. (
  • With InteractionsGuide™ you will be able to engage your patients in active dialogue and inventory their use of herbs and nutrients to assess potential interactions, evaluate therapeutic strategies, ensure safe prescribing, and collaborate on complex cases using this authoritative, scientifically-grounded and clinically-oriented reference tool. (
  • Interactions enables you to coordinate safe, reliable therapy and collaborate in multidisciplinary therapeutic strategies. (
  • Importantly, many of these drugs have very narrow therapeutic indices. (
  • Plants upregulate and downregulate their biochemical paths in response to a local mix of herbivores, pollinators, and microorganisms .The chemical profile of a single plant may vary over time as it reacts to changing conditions Plant synthesize a bewildering array of is these secondary metabolites and pigments that have therapeutic actions in humans and are refined to produce drugs. (
  • Herbal remedies: adverse effects and drug interactions, A growing number of americans are using herbal products for preventive and therapeutic purposes. (
  • The advantages of combining Chinese herbs and drugs include better therapeutic results than both alone, lower does of the drugs required, and fewer side effects of drugs due to a lower does and herbal actions on counteracting the side effects of drugs (4) . (
  • As well as a graying population that may be on multiple medication treatment for various common ailments such as hypertension, heart disease, and diabetes, we can expect that herbal-drug interactions could be a real concern from a safety and therapeutic point of view," Kwong said. (
  • We produce reviews of the therapeutic use of leading herbal medicinal products or herbal drug preparations based on scientific evidence and on leading expertise across Europe. (
  • Summarizes in a clear and concise way data related to efficacy, dose, and safety for the therapeutic use of herbal drugs. (
  • Drug interaction predictors enable risk assessment of multiple drugs simultaneously with visualizations risk per therapeutic classes, to indicate a spectrum from no risk to high risk. (
  • An increase in the drug dosage could occur when an herb component aids absorption of the drug or inhibits the enzymes that break down the drug or guide it out of the body. (
  • This necessitates individual adjustment of dosage according to the response of the condition and the patient's tolerance of the drug. (
  • Almost all of the dosage/safety information that exists about CBD comes from the work done by English company GW Pharma in the development of its drug Epidiolex. (
  • So, this interaction made it as if you had taken a higher dosage of ephedra. (
  • Cholesterol -lowering drugs including cholestyramine and colestipol interfere with the absorption of iron. (
  • Conversely, iron decreases the absorption of some drugs including antibiotics like quinolones and tetracyclines and ACE inhibitors that treat high BP. (
  • Absorption is about getting the herb into the bloodstream. (
  • The clinical impact of this interaction is not fully known, but be aware that some herbal teas such as pennyroyal reduce iron absorption similarly to conventional tea , which is not generally considered to be a suitable drink for babies and children, because of its effects on iron absorption. (
  • The gastrointestinal absorption of drugs may be affected by concurrent use of other agents due to the large surface area of the tract upon which the drug can be absorbed, bind or chelate, or alter in term of gastrointestinal motility. (
  • Be aware that the fiber of acacia may impair the absorption of oral drugs. (
  • Use of acacia as a surfactant (substance that lowers surface tension) may increase the intestinal absorption of some anticancer drugs. (
  • Compounds derived from botanicals are known to interfere with CYP enzymes and transporters, thereby affecting the way substrate drugs are metabolized. (
  • Caffeine in coffee is processed by the same liver enzymes as many drugs. (
  • Herbs like valerian and turmeric, which inhibit these enzymes, can therefore make tamoxifen less effective. (
  • Summary tables of relevant drug-herb interactions are presented both for the individual herbs included and at the level of the CYP450 enzymes. (
  • Joanna Harnett, BHlthSc, MHlthSc, PhD, of The University of Sydney in Australia, told Cancer Therapy Advisor that "a number of herbs induce or inhibit the cytochrome (CYP) P450 enzymes or the activity of drug transporters such as p-glycoprotein. (
  • Background: Herbal products have grown steadily across the globe and have increasingly been incorporated into western medicine for healthcare aims, thereby causing potential pharmacokinetic Herb-drug Interactions (HDIs) through the inhibition or induction of drug-metabolizing enzymes and transporters. (
  • The growing number of CES substrate drugs also underscores the importance of the enzymes. (
  • A decrease in the amount of drug could occur as a result of herb components binding up some of the drug and preventing it getting into the blood stream from the gastrointestinal tract, or by stimulating the production and activity of enzymes that degrade the drug and prepare it for elimination. (
  • The breakdown of milk thistle by certain liver enzymes may interfere with the action of drugs that are metabolized by those same enzymes. (
  • This review paper summarizes drug-herb interactions involving inhibition or induction of cytochrome P450 enzymes, drug transporters as well as modulation of drug pharmacodynamics. (
  • Information about drug components, interactions, usage in pregnancy , while breastfeeding , for pediatric patients, and dosing limits are outlined and made available in standard references for doctors treating patients. (
  • Dr. Yeung touches on the cancer drugs most prone to these interactions, and discusses the importance of healthcare providers in asking patients about complementary medicine use. (
  • Doctors should monitor patients closely if they are receiving cancer drugs and taking herbs, Dr. Yeung advises, and make adjustments to the drug dose or route of administration if needed. (
  • 8] In this article, we focus on "herbs" used by cancer patients and survivors. (
  • Patients who drink alcohol while taking nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of stomach bleeding. (
  • This herb, Hypericum perforatum , had been used primarily for its anti-depressant actions, but it also had been shown in laboratory tests to possess HIV-inhibiting action, which attracted HIV-infected patients to the herb even more. (
  • 1,2 Given that these patients also use many prescription drugs, interactions caused by polypharmacy are common and problematic. (
  • However, patients with cancer tend to use herbs that are promoted as alternative cures. (
  • To investigate drug-gene interactions on the incidence of non-fatal myocardial infarction and stroke for hypertensive patients. (
  • The DECART study will determine if primary care physicians, including internists and family physicians, are able to identify and address drug-drug interactions among simulated patients and. (
  • Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. (
  • Although the drug is generally considered safe and effective, many clinical studies have shown that approximately 5-40% of patients displayed inadequate antiplatelet responses [ 2 , 4 ]. (
  • Herbs that warm the interior and strengthen Kidney Yang and Qi must be used with caution when patients take drugs that raise the blood pressure or increase heart contractility (force of contraction). (
  • Patients taking drugs that raise blood pressure and heart contractility should use caution if taking alpha-agonists such as pseudoephedrine (Sudafed). (
  • Patients taking drugs that raise blood pressure and heart contractility should use caution if taking phenylephrine. (
  • Use extreme caution with patients who have a history of cardiovascular disorders or are taking antiarrhythmic drugs. (
  • Critical evaluation of causality assessment of herb-drug interactions in patients. (
  • Ensure the safety of your patients and your practice with an understanding of possible herb-drug interactions. (
  • This herb may induce CYP3A4 activity, decreasing exposure to antiretroviral drugs such as indinavir or nevirapine ( 6 , 18 ) and putting patients at risk of treatment failure and subsequent development of viral resistance to antiretroviral drugs. (
  • It behooves all practitioners to not only ask patients what they are taking, but also understand potential interactions and deficiencies that might occur and make recommendations. (
  • Whether physician or pharmacist, educator or researcher, Herb, Nutrient and Drug Interactions can guide you in delivering safe, individualized and evolving treatment strategies for your patients. (
  • The aim of this study was to find the prevalence of potential drug-herb interactions in patients with chronic diseases and identify factors associated with these interactions if present. (
  • Among the patients, 237 (59.3 %) were using 395 medicinal herbs. (
  • Male patients were more likely to have potential drug-herb interactions. (
  • Use of medicinal herbs is a common practice among Palestinian patients attending primary healthcare centers. (
  • A substantial proportion failed to disclose to their doctors or pharmacists about herbal products they used, therefore, the physicians and pharmacists are recommended to ask patients about the use of medicinal herbs to avoid any possible negative outcomes. (
  • If a second course of therapy is needed, it can be initiated eight or more weeks after completion of the first course, since experience has shown that patients may continue to improve while off the drug. (
  • In general, patients initially should receive EPURIS® 0.5 mg/kg body weight daily for a period of two to four weeks, when their responsiveness to the drug will usually be apparent. (
  • A survey done by Beijing Hospital of Chinese Medicine indicated that 57.34% of patients who are treated with conventional drugs are taking Chinese herbs simultaneously (3) . (
  • However with so many patients are treated with conventional drugs and Chinese herbs together, the safety concern raised in general public and other health care providers. (
  • Kwong warns patients to be especially careful about taking herbal and drug products that serve the same purpose. (
  • Patients usually take several drugs for the treatment of one or more health problems at the same time. (
  • Do herbs increase the risk of herb-drug interactions for patients with arthritis? (
  • Patients taking selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, or other drugs that affect serotonin levels should avoid taking 5-HTP without the supervision of a physician due to the theoretical potential for serotonin syndrome, a serious condition, or other side effects. (
  • A synergistic interaction may be beneficial for patients, but may also increase the risk of overdose. (
  • Better knowledge in this area will help avoid negative interactions and may also help enable synergistic interactions. (
  • The herbs and the drugs have similar functions and therefore may have a synergistic or additive effect when combined. (
  • Interactions can be additive, synergistic, and antagonistic. (
  • Synergistic interactions occur when taking two or more substances together results in a stronger action than the sum of taking them separately. (
  • For example, herbs containing vitamin K may be antagonistic and blood invigorating herbs tend to be additive or synergistic. (
  • However, it is crucial to evaluate potential antagonistic, additive, or synergistic interactions that may result from the co-treatment of this plant in chemotherapy. (
  • When two drugs are used together, their effects can be additive (the result is what you expect when you add together the effect of each drug taken independently), synergistic (combining the drugs leads to a larger effect than expected), or antagonistic (combining the drugs leads to a smaller effect than expected). (
  • There is sometimes confusion on whether drugs are synergistic or additive, since the individual effects of each drug may vary from patient to patient. (
  • Over 80 herbs or botanicals (including plants, fungi, algae, and common constituents) were identified that had clinically significant interactions with prescription and over-the-counter drugs. (
  • This, together with limited evidence to support the safety of many of these combinations, makes it possible for potentially significant interactions between certain types of CAM and antiretroviral drugs to occur. (
  • one can foresee possible significant interactions and thus take precautions to avoid incompatibilities and serious result. (
  • Clinically significant interactions also include interactions of high risk that may result in an immediate, life-threatening adverse event even if their supporting data is not obtained through the above mentioned sources. (
  • Is black cohosh a hepatotoxic medicinal herb? (
  • There are food-drug interactions and food-herb interactions. (
  • Such undesired responses can occur with drug-drug interactions and with food-drug interactions (especially from the impact of grapefruit juice), so the finding of some instances of herb-drug interaction would not be surprising. (
  • To fully appreciate the clinical impact, both the drug and the herb must be studied together in humans. (
  • To understand the precise effects of herb-drug interactions in humans, both the herb and drug need to be studied together in a clinical setting. (
  • Additionally, drug-induced depletion of nutrients can occur. (
  • Due to this interaction high blood pressure and congestive heart failure also can occur. (
  • Both synergy and antagonism occur during different phases of the interaction between a drug, and an organism. (
  • Direct interactions between drugs are also possible and may occur when two drugs are mixed prior to intravenous injection. (
  • Pharmacodynamic interactions can occur on: Pharmacological receptors: Receptor interactions are the most easily defined, but they are also the most common. (
  • In other cases, a doctor or pharmacist may recommend the patient take some other drugs with milk or a bit of dairy to minimize the risk of upset stomach. (
  • If you take herbals and drugs it is important to check with your doctor or pharmacist. (
  • Your pharmacist can cross reference the drug and herb and check for known interactions. (
  • The indiscriminate use of medicinal plants and herbal medicinal products concomitantly with conventional drugs may result in herb-drug interactions that may lead to fluctuations in drug bioavailabilit. (
  • This lecture has been broken into eleven chapters and may be viewed by clicking on the links provided, beginning with Introduction to Clinically Relevant Herb-Drug Interactions . (
  • Knowledge of drug-herb interactions is limited and much more research needs to be done to further document clinically relevant interactions. (
  • These findings support the use of a SCHH system that maintains transport, metabolic, and regulatory functionality for routine HDI assessments to predict clinically relevant clearance interactions. (
  • Glycyrrhizin is a compound in licorice that may reduce the effectiveness of certain drugs, like the immunosuppressant cyclosporine. (
  • In traditional herb pharmacies in China there is posted an ancient recitation of 18 incompatibles, namely three herbs (aconite, licorice, and veratrum) with 4 6 other specified drugs for each that are not to be combined because, according to this doctrine, their mixture would cause adverse effects. (
  • Using with immune stimulating herbs such as astragalus, echinacea, licorice root, alfalfa sprouts, and zinc lozenges might offset the immunosuppressive results. (
  • Licorice is an herb that lends flavor to many foods and beverages. (
  • The German Commission E, the European equivalent of the U.S. Food and Drug Administration, suggests limiting licorice supplementation to six weeks, unless otherwise directed by a healthcare practitioner experienced in botanical medicine. (
  • Licorice can interfere with drugs that suppress the immune system such as steroids including prednisone. (
  • Some research shows this herb's anti-depressant effect rivals conventional anti-depressant drugs for mild to moderate depression! (
  • Interaction between herbal products and conventional drugs is one of the major safety concerns these days. (
  • Of serious concern is the concurrent consumption of herbal products and conventional drugs. (
  • Conclusion: Nonclinical and clinical studies on HDIs are warranted in the future to provide safety information toward better clinical outcomes for the combination of herbal products and conventional drugs. (
  • In China Chinese herbs are very often prescribed together with conventional drugs. (
  • Includes articles related to the investigation of Western botanicals or whole herbal extracts in human subjects, investigating either the impact on Cytochrome P450 isoenzymes or an assessment of specific drug-herb interactions within a clinical trial. (
  • Various research studies, performed using the standardized extracts of B. monnieri , have demonstrated the herb to facilitate the processes of acquisition, retention, and retrieval of learned tasks. (
  • Interaction between different extracts of Hypericum perforatum L. from Serbia and pentobarbital, diazepam and paracetamol. (
  • The most important pharmacokinetic effects of cannabis depend on whether the herb (or its extracts) are smoked or taken orally. (
  • In this study, we demonstrate the drug-herb interaction using combination treatment of C. nutans extracts and cyclophosphamide on the WRL 68 cell line. (
  • Infusions are hot water extracts of herbs, such as chamomile or mint, through steeping. (
  • Tinctures are alcoholic extracts of herbs, which are generally stronger than herbal teas. (
  • Herb-drug interactions may be classified in two major categories: pharmacokinetic and pharmacodynamic interactions. (
  • The change in an organism's response upon administration of a drug is an important factor in pharmacodynamic interactions. (
  • It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. (
  • Isolated pharmaceutical drugs, in a form similar to those we rely on today, were first produced in Europe about 150 years ago. (
  • Recognize pros and cons of pharmaceutical drugs and herbal medicine. (
  • However, there can be difficulties with this as the chemicals in the two preparations can connect - altering the effect of the pharmaceutical drugs and the herbs. (
  • Herbs can in lots of instances offer a much safer alternative to pharmaceutical medication (particularly when other measures to enhance health are likewise undertaken). (
  • Evidence-based content includes the most up-to-date, current research on herb/supplement and pharmaceutical interactions. (
  • In turn, this leads to growing number of sales of commercialised medicinal herbs and most importantly, growing number of pharmaceutical companies that involve in the research and development of plants as a source for modern medicine. (
  • Another example is tamoxifen, a drug that relies on CYP2D6 and CYP3A4 to be metabolized to its active form. (
  • Development of Caco-2 cells-based gene reporter assays and evaluation of herb-drug interactions involving CYP3A4 and CYP2D6 gene expression. (
  • Because many herbs have demonstrated adverse effects on the liver, the potential for interaction with hepatotoxic agents (such as acetaminophen) is also significant. (
  • Drug-induced depletion of essential nutrients can contribute to acute and long-term adverse effects that are preventable with informed clinical management. (
  • I was especially impressed by Dr. Stargrove and his interdisciplinary team's ranking of the quality of the available evidence as well as their careful consideration of beneficial interactions, not just adverse effects. (
  • this enzyme degrades many drugs. (
  • This is the same enzyme that is inhibited by grapefruit juice, which has the opposite effect of increasing drug levels in the blood. (
  • Since drugs as chemicals work outside the system, and whole herbs as foods are processed through our enzyme system, a theorized interaction often never occurs or is neutralized. (
  • Specific effects of drugs and substances on metabolic pathways such as those occurring through the CYTOCHROME P-450 ENZYME SYSTEM. (
  • The animal study indicated that clopidogrel and XST coadministration produced significant herb-drug interactions at active CAMD pharmacokinetic and CES1A metabolic enzyme aspect. (
  • In particular, enzyme induction and inhibition may play an important role in the occurrence of some herbdrug interactions. (
  • OAT1 and OAT3 are almost exclusively expressed in the kidney, responsible for the renal secretion of a large variety of drugs, including angiotensin- converting-enzyme (ACE) inhibitors, diuretics, antibiotics, and antivirals ( Burckhardt, 2012 ). (
  • The question then arises: how many other herbs might have this effect on the drugs of concern for people with HIV? (
  • However, a serious concern is the potential appearance of clinically significant drug⁻her. (
  • My concern is the STATIN drug. (
  • Herb-drug interactions are not the only concern. (
  • After the first such reports emerged in the 1990s, a concern has been raised: that we know so little about herbs and their potential for interaction with drugs that these incidents could be just the "tip of the iceberg. (
  • drug-drug interactions (ddis) are a concern for the prescriber because they have the potential for causing untoward outcomes for everyone involved. (
  • However, worse outcomes were observed raising concern about a critical issue, herb-drug interactions, which were rarely reported when antipsychotics were included. (
  • In other cases, as with the antihistamine fexofenadine (Allegra), grapefruit and grapefruit juice decrease both the blood levels of the drug and its effectiveness. (
  • o Digoxin - lanoxin (a heart drug). (
  • Some herbs are digoxin like and have the same effect as the medical drug. (
  • Taking these herbs together with digoxin is like taking an overdose. (
  • Digoxin interaction with Food, Herbs and Alcohol - It is important to know how to take the medication to avoid the drug-food interaction. (
  • Due to this interaction, the effectiveness of digoxin in treating heart failure may be decreased. (
  • Mixing of alcohol with digoxin will decrease the amount of the drug in your bloodstream which may cause abnormalities in heart function. (
  • You should not change the brand of digoxin as different brands have a different amount of active drug. (
  • The situation surrounding HIV infection appeared brighter in the late 1990s, with the virus better controlled and with herbs apparently able to help alleviate a variety of symptoms as well as reducing the anxiety that accompanies taking drugs that are, in the view of many, toxic substances. (
  • The use of potent and toxic substances and the intentional alteration of natural substances are characteristics of production of modern drugs. (
  • Clinicians need to be aware of potential drug interactions between prescribed and nonprescribed substances. (
  • Antagonistic interactions are when taking substances together weakens their overall effect. (
  • A possible interaction refers to the possibility that one substance may alter the bioavailability or the clinical effectiveness of another substance when two or more substances are given concurrently. (
  • The interaction may result in an increase or a decrease in effect of one (drug or herb) or both substances. (
  • These side effects are described and reported after drug trials and research studies have been conducted. (
  • It should be noted that simply because herbs are "natural" treatments, they are not necessarily free from side effects. (
  • It must be kept in mind that herbs are powerful, and in some instances there may be a drug and herb interaction which can cause unwanted side effects . (
  • A food, drink, drug, or herb may decrease or increase the effects of a medication, prevent it from working, or increase or decrease medication side effects. (
  • New side effects may emerge from an interaction. (
  • Herbs were also considered a possible means to minimize drug side effects. (
  • others routinely recommend them, especially if a drug is leaching nutrients from the body or causing side effects. (
  • For instance, ginkgo biloba may be taken to help counteract the sexual side effects of anti-depressant drugs. (
  • This is certainly good news for people who want a natural alternative to drugs like Prozac which can cause side effects like low libido, agitation or fatigue. (
  • Are there chances of side effects/allergies/reactions/drug herb interactions? (
  • We will guide and inform you about any mild or moderate or severe side effects or interactions based on clinical research studies and our experience. (
  • We suggest you to contact us if you experience some side effects or reaction or interaction so that we can help you at the earliest. (
  • Unexpected side effects from herb-drug interactions are a real and often devastating possibility. (
  • In addition, Dr. Chen also discusses the safe and defensive practice guidelines to minimize side-effects, adverse reactions, and herb-drug interactions. (
  • Herbs are powerful , and although some misguided people still insist that they cannot achieve much, the fact is that they can be used successfully in a variety of cases, and in most cases have less side effects than other remedies . (
  • Not all herbs have such dramatic side effects as that of comfrey - and a large amount of them work gently to achieve their magic, yet, people should not be lulled into a false sense of security, just because a capsule or cream is classified as herbal or natural . (
  • In fact, many do, but if herbal remedies are effective, they must contain biologically active chemicals, and that increases the possible risk of side effects and interaction with other drugs. (
  • an increase in drug level could produce side effects. (
  • Besides this, advances in the human genome, increase knowledge of the structure and function of proteins and the notion that synthetic drugs are safer with fewer side effects (which does not necessarily be true) also contributed to the rise in the popularity of synthetic drugs. (
  • Because many of these drugs also affect serotonin levels, there is an increased risk for side effects or toxicities if you also take 5-HTP. (
  • A drug interaction is a change in the action or side effects of a drug caused by concomitant administration with a food, beverage, supplement, or another drug. (
  • Present results suggest that herbal medical preparations such red clover has potential for herb drug interaction. (
  • In cases of co-administration, the potential for herb-drug interactions (HDI) increases. (
  • Combining a drug that lowers blood sugar with an herb that does so is sometimes thought of as having a potential for herb-drug interaction, but it is simply two methods of accomplishing the same task of reaching normal levels so does not produce clinical reports of adverse conseuqences. (
  • Several studies tout Astragalus' usefulness as an antioxidant and anti-inflammatory herb. (
  • The interactions arise from Astragalus having a similar effect as the medication, for example, it may lower blood pressure therefore making high blood pressure medication stronger. (
  • Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. (
  • Instead, the interaction most often involves having an herb component cause either an increase or decrease in the amount of drug in the blood stream. (
  • The problem is that it can take several weeks for the body to decrease the amount of drug in the system. (
  • While theoretically the tannins found in the herb may decrease water content of stool, and mucilage may act as a soothing agent to inflamed mucous membranes, there is no reliable scientific evidence to support this indication. (
  • Complementary therapies, herbs, and other OTC agents. (
  • and pharmacodynamics, which define how herbs can alter the actions of other drugs when used concurrently. (
  • These concepts have fundamental applications in the pharmacodynamics of these interactions. (
  • Dr. John Chen, a recognized authority in western pharmacology and Chinese herbal medicine, author, and faculty of the USC School of Pharmacology and many TCM colleges, shares the most appropriate herb-drug interactions in relation to Evergreen Herbs' Collection formulas . (
  • The issue of herb-drug interactions looms large over the practice of herbal medicine. (
  • This review tries to expound on the importance of herbal medicine in modern drug development by highlighting salient topics from the history of herbal medicine and examining its roles in modern drug development. (
  • Clinical outcomes of reported herb-drug interactions ranged from mild to severe. (
  • The in vitro data suggested that there was a potential for drug-herb interactions, which could negatively affect the chemotherapeutic outcomes. (
  • In some cases, a drug-herb interaction occurs because an herb is misused, taken in very high doses or combined with a medication that has a similar effect (i.e. combinining blood thinning drugs with blood thinning herbs). (
  • There are even cases where an herbal formula can be used to help a person wean off a drug medication, but these cases should always be monitored medically. (
  • It is ludicrous for an obese person to sue a hamburger company for their weight problem, or for another to file suit against a drug company after abusing or taking medication incorrectly. (
  • We have compiled a list of such herbs , for the interest of our visitors, but care should be taken during pregnancy and lactation when taking any medication or supplement, and is best discussed with your health practitioner. (
  • As with any supplement, you should check for drug interactions to avoid medication problems . (
  • Sheng-Nongs Herbal Book, one of the earliest sources of folk knowledge on the use of herbs in China, dated back to 3000 B.C. and included knowledge of 365 plants, animals and minerals useful as medication 1 . (
  • Among drugs used in oncology, cases involving cyclosporine (16), heparin (14), and tamoxifen (11) have been reported. (
  • The objective of this study was to describe the prevalence of CM use and the potential for interactions with cancer treatments in an academic oncology centre. (
  • Much of the information we have on herb-nutrient- drug interactions comes from anecdotal reports or small tests. (
  • Herb, nutrient, drug interactions are rare but can happen. (
  • As the title suggests, this book addresses herb-drug interactions, nutrient-drug interactions, and drug-induced nutrient depletions in a clinically oriented, and integrated manner. (
  • Conversely, drug-induced depletion of nutrients can be prevented through protective and corrective strategies. (
  • Drug-nutrient depletion and interaction charts, Much of the information on this page came from ross pelton's drug-induced nutrient depletion handbook, because he posted it on the nutrition science news website. (
  • We will talk about preventing herb and drug interactions, quality control, nutritional depletion and even touch on the idea of positive herb and drug interactions. (
  • Organic anion transporter 1 (OAT1) and 3 (OAT3) are highly expressed in the kidney and play a key role in the renal elimination of substrate drugs. (
  • Herb-drug interactions (HDIs) resulting from concomitant use of herbal products with clinical drugs may cause adverse reactions. (
  • It emphasises safe practice with strategies to prevent adverse drug reactions, guidelines in assessing benefit, risk and harm and the evaluation of research. (
  • These in vitro pharmacokinetic interactions indicate the selected herbal products may affect indinavir's bioavailability, but the clinical significance needs to be confirmed with in vivo studies before final conclusions can be made. (
  • Unique icons throughout the text differentiate interactions, evidence, and clinical significance. (
  • An innovative evaluation system and unique icons differentiate interactions, qualify evidence, and assess clinical significance. (
  • Innovative icon-based evaluation taxonomy visually differentiates interactions, evidence, and clinical significance. (
  • Therefore, professional judgment is often necessary when evaluating the clinical significance of a potential herb-drug interaction. (
  • herb interaction with antiplatelet/anticoagulant drugs. (