INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
INFLAMMATION of the LIVER in humans caused by a member of the HEPATOVIRUS genus, HUMAN HEPATITIS A VIRUS. It can be transmitted through fecal contamination of food or water.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
INFLAMMATION of the LIVER.
Antigens of the virions of HEPACIVIRUS, their surface, core, or other associated antigens.
INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).
INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
Immunoglobulins raised by any form of viral hepatitis; some of these antibodies are used to diagnose the specific kind of hepatitis.
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
A species in the genus HEPATOVIRUS containing one serotype and two strains: HUMAN HEPATITIS A VIRUS and Simian hepatitis A virus causing hepatitis in humans (HEPATITIS A) and primates, respectively.
Antibodies to the HEPATITIS B ANTIGENS, including antibodies to the surface (Australia) and core of the Dane particle and those to the "e" antigens.
INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors.
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.
Ribonucleic acid that makes up the genetic material of viruses.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion.
Vaccines or candidate vaccines used to prevent infection with hepatitis A virus (HEPATOVIRUS).
A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic hepatitis B, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins G.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Any vaccine raised against any virus or viral derivative that causes hepatitis.
Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.
Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.
A positive-stranded RNA virus species in the genus HEPEVIRUS, causing enterically-transmitted non-A, non-B hepatitis (HEPATITIS E).
INFLAMMATION of the LIVER in animals due to viral infection.
Antibodies to the HEPATITIS A ANTIGENS including antibodies to envelope, core, and non-structural proteins.
Any of the viruses that cause inflammation of the liver. They include both DNA and RNA viruses as well viruses from humans and animals.
A strain of HEPATITIS A VIRUS which causes hepatitis in humans. The virus replicates in hepatocytes and is presumed to reach the intestine via the bile duct. Transmission occurs by the fecal-oral route.
Proteins found mainly in icosahedral DNA and RNA viruses. They consist of proteins directly associated with the nucleic acid inside the NUCLEOCAPSID.
INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS, a defective RNA virus that can only infect HEPATITIS B patients. For its viral coating, hepatitis delta virus requires the HEPATITIS B SURFACE ANTIGENS produced by these patients. Hepatitis D can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis B, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
A defective virus, containing particles of RNA nucleoprotein in virion-like form, present in patients with acute hepatitis B and chronic hepatitis. It requires the presence of a hepadnavirus for full replication. This is the lone species in the genus Deltavirus.
INFLAMMATION of the LIVER in non-human animals.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Any DNA sequence capable of independent replication or a molecule that possesses a REPLICATION ORIGIN and which is therefore potentially capable of being replicated in a suitable cell. (Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).
Proteins prepared by recombinant DNA technology.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Tumors or cancer of the LIVER.
The transference of a part of or an entire liver from one human or animal to another.
Therapy with two or more separate preparations given for a combined effect.
A condition characterized by the presence of abnormal quantities of CRYOGLOBULINS in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.
Tetraspanin proteins that are involved in a variety of cellular functions including BASEMENT MEMBRANE assembly, and in the formation of a molecular complexes on the surface of LYMPHOCYTES.
Abuse, overuse, or misuse of a substance by its injection into a vein.
A genus of PICORNAVIRIDAE causing infectious hepatitis naturally in humans and experimentally in other primates. It is transmitted through fecal contamination of food or water. HEPATITIS A VIRUS is the type species.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Antigens from any of the hepatitis viruses including surface, core, and other associated antigens.
Antigens produced by various strains of HEPATITIS A VIRUS such as the human hepatitis A virus (HEPATITIS A VIRUS, HUMAN).
INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Antigens produced by various strains of HEPATITIS D VIRUS.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
'Blood donors' are individuals who voluntarily and safely donate a specific amount of their own blood, which can be further separated into components, to be used for transfusion purposes or for manufacturing medical products, without receiving remuneration that is intended to reward them financially.
The common chimpanzee, a species of the genus Pan, family HOMINIDAE. It lives in Africa, primarily in the tropical rainforests. There are a number of recognized subspecies.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A DNA virus that closely resembles human hepatitis B virus. It has been recovered from naturally infected ducks.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
A country in northern Africa, bordering the Mediterranean Sea, between Libya and the Gaza Strip, and the Red Sea north of Sudan, and includes the Asian Sinai Peninsula Its capital is Cairo.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A family of RNA viruses, many of which cause disease in humans and domestic animals. There are three genera FLAVIVIRUS; PESTIVIRUS; and HEPACIVIRUS, as well as several unassigned species.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
An ORTHOHEPADNAVIRUS causing chronic liver disease and hepatocellular carcinoma in woodchucks. It closely resembles the human hepatitis B virus.
Simultaneous infection of a host organism by two or more pathogens. In virology, coinfection commonly refers to simultaneous infection of a single cell by two or more different viruses.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The presence of viruses in the blood.
Established cell cultures that have the potential to propagate indefinitely.
Pathological processes of the LIVER.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The indelible marking of TISSUES, primarily SKIN, by pricking it with NEEDLES to imbed various COLORING AGENTS. Tattooing of the CORNEA is done to colorize LEUKOMA spots.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.
A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
The return of a sign, symptom, or disease after a remission.
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.
INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS in conjunction with HEPATITIS B VIRUS and lasting six months or more.
Disease having a short and relatively severe course.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
A genus of Sciuridae consisting of 14 species. They are shortlegged, burrowing rodents which hibernate in winter.
Elements of limited time intervals, contributing to particular results or situations.
The relationships of groups of organisms as reflected by their genetic makeup.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Proteins found in any species of virus.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Viral diseases which are transmitted or propagated by sexual conduct.
Infectious organisms in the BLOOD, of which the predominant medical interest is their contamination of blood-soiled linens, towels, gowns, BANDAGES, other items from individuals in risk categories, NEEDLES and other sharp objects, MEDICAL WASTE and DENTAL WASTE, all of which health workers are exposed to. This concept is differentiated from the clinical conditions of BACTEREMIA; VIREMIA; and FUNGEMIA where the organism is present in the blood of a patient as the result of a natural infectious process.
Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.
A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.
Hospital units in which care is provided the hemodialysis patient. This includes hemodialysis centers in hospitals.
The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.
A family of proteins that promote unwinding of RNA during splicing and translation.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Proteins which are synthesized as a single polymer and then cleaved into several distinct proteins.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Genotypic differences observed among individuals in a population.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
A spontaneous diminution or abatement of a disease over time, without formal treatment.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A genus in the subfamily CALLITRICHINAE consisting of 12 species and found in Panama as well as South America. Species seen most frequently in the literature are S. oedipus (cotton-top marmoset), S. nigricollis, and S. fusicollis.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
'Prisoners,' in a medical context, refer to individuals who are incarcerated and may face challenges in accessing adequate healthcare services due to various systemic and individual barriers, which can significantly impact their health status and outcomes.
A cell line derived from cultured tumor cells.
Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.
Infections with viruses of the family FLAVIVIRIDAE.
Penal institutions, or places of confinement for war prisoners.
I'm sorry for any confusion, but "Brazil" is not a medical term or concept, it is a country located in South America, known officially as the Federative Republic of Brazil. If you have any questions related to health, medicine, or science, I'd be happy to help answer those!
A species of virus (tentatively placed in the genus HEPACIVIRUS) in the family FLAVIVIRIDAE, that was recovered from a tamarin monkey, but may have been of human origin. It causes HEPATITIS in several species of New World monkeys.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The interactions between a host and a pathogen, usually resulting in disease.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Diagnostic procedures involving immunoglobulin reactions.
Usage of a single needle among two or more people for injecting drugs. Needle sharing is a high-risk behavior for contracting infectious disease.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.
A species of virus (unassigned to a genus) in the family FLAVIVIRIDAE. It is genetically heterogeneous, of human origin, and transmitted by blood or blood products. Despite its alternate name (Hepatitis G virus), its pathogenicity remains controversial.
The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.
Substances elaborated by viruses that have antigenic activity.
Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
The transmission of infectious disease or pathogens from one generation to another. It includes transmission in utero or intrapartum by exposure to blood and secretions, and postpartum exposure via breastfeeding.
I'm sorry for any confusion, but "Pakistan" is a country located in South Asia and it does not have a medical definition. If you have any medical question or term that you would like me to define, please provide it and I will be happy to help.
The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.
"Ducks" is not a recognized medical term or condition in human health; it may refer to various anatomical structures in animals, such as the ducks of the heart valves, but it does not have a standalone medical definition.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
The functional hereditary units of VIRUSES.
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
Sites on an antigen that interact with specific antibodies.
The perforation of an anatomical region for the wearing of jewelry.
A country spanning from central Asia to the Pacific Ocean.
A genus of tree shrews of the family TUPAIIDAE which consists of about 12 species. One of the most frequently encountered species is T. glis. Members of this genus inhabit rain forests and secondary growth areas in southeast Asia.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
People who take drugs for a non-therapeutic or non-medical effect. The drugs may be legal or illegal, but their use often results in adverse medical, legal, or social consequences for the users.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
A bile pigment that is a degradation product of HEME.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
A family of hepatotropic DNA viruses which contains double-stranded DNA genomes and causes hepatitis in humans and animals. There are two genera: AVIHEPADNAVIRUS and ORTHOHEPADNAVIRUS. Hepadnaviruses include HEPATITIS B VIRUS, duck hepatitis B virus (HEPATITIS B VIRUS, DUCK), heron hepatitis B virus, ground squirrel hepatitis virus, and woodchuck hepatitis B virus (HEPATITIS B VIRUS, WOODCHUCK).
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
Penetrating stab wounds caused by needles. They are of special concern to health care workers since such injuries put them at risk for developing infectious disease.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The term "United States" in a medical context often refers to the country where a patient or study participant resides, and is not a medical term per se, but relevant for epidemiological studies, healthcare policies, and understanding differences in disease prevalence, treatment patterns, and health outcomes across various geographic locations.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Unassigned species, in the family PICORNAVIRIDAE, causing high mortality in ducklings 3 days to 3 weeks old.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
The transmission of infectious disease or pathogens from patients to health professionals or health care workers. It includes transmission via direct or indirect exposure to bacterial, fungal, parasitic, or viral agents.
A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
I'm sorry for any confusion, but "Italy" is not a medical term or concept, it's a country located in Southern Europe. If you have any questions related to medical topics, I'd be happy to help with those!
An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.
Virus diseases caused by the HEPADNAVIRIDAE.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
I'm sorry for any confusion, but "Taiwan" is not a medical term and does not have a medical definition. It is a country located in East Asia. If you have any questions related to healthcare or medical terms, I would be happy to help with those!
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

In vivo analysis of the 3' untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone. (1/5458)

Large sections of the 3' untranslated region (UTR) of hepatitis C virus (HCV) were deleted from an infectious cDNA clone, and the RNA transcripts from seven deletion mutants were tested sequentially for infectivity in a chimpanzee. Mutants lacking all or part of the 3' terminal conserved region or the poly(U-UC) region were unable to infect the chimpanzee, indicating that both regions are critical for infectivity in vivo. However, the third region, the variable region, was able to tolerate a deletion that destroyed the two putative stem-loop structures within this region. Mutant VR-24 containing a deletion of the proximal 24 nt of the variable region of the 3' UTR was viable in the chimpanzee and seemed to replicate as well as the undeleted parent virus. The chimpanzee became viremic 1 week after inoculation with mutant VR-24, and the HCV genome titer increased over time during the early acute infection. Therefore, the poly(U-UC) region and the conserved region, but not the variable region, of the 3' UTR seem to be critical for in vivo infectivity of HCV.  (+info)

Hepatitis virus infection in haemodialysis patients from Moldavia. (2/5458)

BACKGROUND: Although the epidemiology of hepatitis B (HBV) and C (HCV) now seems well established for Western European countries, in Central and Eastern Europe < 50% of all dialysis centres routinely test for hepatitis C antibodies since testing is not available or is not applied to all patients. This study describes the prevalence, risk factors and clinical significance of HBV and HCV infection for the haemodialysis population of the North Eastern region of Romania, Moldavia. METHODS: The presence of HBV antigens was determined with an ELISA kit (Wellcome, Abbot) and HCV antibodies with the ELISA-3 Ortho-HCV, third generation test. The following individual data were collected: gender, age, duration of dialysis, rural/urban domicile, actual and previous HBV status, actual HCV status, known acute, clinically evident hepatitis episodes in the last 3 years, monthly alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) levels, complete biochemical hepatic assessment at the time of the study, transfusions for the past 3 years and family history. RESULTS: HBV and HCV prevalences were 17% (stable over the last 3 years) and 75%, respectively; co-infection was seen in 10% of the subjects. Hospitalization (nosocomial infection) for HBV, blood transfusions and duration on dialysis for HCV, emerged as the main risk factors for hepatitis infection. Socio-economic conditions appear to be equally important for HCV infection, since the prevalence was significantly higher among patients from rural, underdeveloped areas than urban areas (80.8 vs 60.3%), and infection was already present in a large proportion of patients (47%) before starting dialysis, without being related to previous disease duration or blood transfusions. HBV and/or HCV was not associated with a worse clinical or biochemical profile at the time of the study. However, infected patients had significantly more previous cytolytic episodes, with higher, transient increases in ALAT and ASAT levels. CONCLUSIONS: HCV infection is endemic among dialysis centres in Moldavia. Apart from previously well-known risk factors for hepatitis infection, our study demonstrates the negative impact of socio-economic underdevelopment. Simple measures such as enforced general asepsia rules, careful disinfection and equipment sterilization, routine testing of patients from economically disadvantaged areas and monthly, serial determination of hepatic enzymes should be the common practice in dialysis centres in Romania.  (+info)

Restricted isotypic antibody reactivity to hepatitis C virus synthetic peptides in immunocompromised patients. (3/5458)

An enzyme immunoassay based on three synthetic peptides from the core, NS4, and NS5 regions of hepatitis C virus allowed the detection of antibodies in 100% of immunocompetent infected patients and in 91% of immunocompromised patients (hemodialysis and hemophiliac patients). Immune impairment seemed to restrict the spectrum of antibody isotypes reacting to the core peptide.  (+info)

Experimental transmission of hepatitis C virus-associated fulminant hepatitis to a chimpanzee. (4/5458)

Hepatitis C virus (HCV) was transmitted from a patient with fulminant hepatitis C to a chimpanzee. The patient had developed two episodes of fulminant hepatitis C, each occurring after a separate liver transplantation. Serial serum and liver samples from the patient and the chimpanzee were analyzed for HCV replication, genotype, quasispecies heterogeneity, and antibodies. In the patient, the levels of HCV replication in serum and liver correlated with the degree of hepatocellular necrosis and the clinical expression of fulminant hepatitis. The same HCV strain, genotype 1a, was recovered from both episodes of fulminant hepatitis. An unusually severe acute hepatitis was also observed in the chimpanzee. The viruses recovered from the patient and the chimpanzee were almost identical and displayed relatively little quasispecies heterogeneity. Thus, the same HCV strain induced two episodes of fulminant hepatitis in a single patient and severe hepatitis in a chimpanzee, suggesting that the pathogenicity or virulence of a specific HCV strain may be important in the pathogenesis of fulminant hepatitis C.  (+info)

Cryoglobulinaemia and rheumatic manifestations in patients with hepatitis C virus infection. (5/5458)

OBJECTIVES: To investigate the association of cryoglobulinaemia and rheumatic manifestations in Korean patients with hepatitis C virus (HCV) infection. METHODS: Forty nine Korean patients with HCV infection were recruited. The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HCV genotype was determined by polymerase chain reaction with genotype specific primer. RESULTS: The prevalence of cryoglobulin was 59% in Korean HCV patients and the concentration of cryoglobulin was 9.8 (7.9) g/l (mean (SD)). The type of cryoglobulinaemia was identified in 23 (80%) of 29 HCV patients with cryoglobulinaemia and they were all type III. There were no differences in age, sex, history of operation and transfusion, proportion of liver cirrhosis between the patients with cryoglobulinaemia and those without cryoglobulinaemia. The frequencies of RF and ANA were 14% and 3.4% respectively in HCV patients with cryoglobulinaemia. There was no difference in HCV genotype between the patients with cryoglobulinaemia and those without cryoglobulinaemia. Clinical features of HCV patients were as follows: arthralgia/arthritis (35%), cutaneous manifestation (37%), Raynaud's phenomenon (8%), paresthesia (44%), dry eyes (22%), dry mouth (10%), oral ulcer (33%), and abdominal pain (14%). However, these rheumatological symptoms did not differ between the two groups. CONCLUSION: Although the rheumatological symptoms were not different between HCV patients with and without cryoglobulinaemia, HCV patients showed various rheumatological manifestations. These result suggests that HCV infection could be included as one of the causes in patients with unexplained rheumatological symptoms.  (+info)

Acute hepatitis C virus structural gene sequences as predictors of persistent viremia: hypervariable region 1 as a decoy. (6/5458)

We hypothesized that hepatitis C virus (HCV) persistence is related to the sequence variability of putative envelope genes. This hypothesis was tested by characterizing quasispecies in specimens collected every six months from a cohort of acutely HCV-infected subjects (mean duration of specimen collection, 72 months after seroconversion). We evaluated 5 individuals who spontaneously cleared viremia and 10 individuals with persistent viremia by cloning 33 1-kb amplicons that spanned E1 and the 5' half of E2, including hypervariable region 1 (HVR1). To assess the quasispecies complexity and to detect variants for sequencing, the first PCR-positive sample was examined by using a previously described method that combines heteroduplex analysis and analysis of single-stranded conformational polymorphisms. The ratio of nonsynonymous to synonymous substitutions (dN/dS) within each sample was evaluated as an indicator of relative selective pressure. Amino acid sequences were analyzed for signature patterns, glycosylation signals, and charge. Quasispecies complexity was higher and E1 dN/dS ratios (selective pressure) were lower in those with persistent viremia; the association with persistence was strengthened by the presence of a combination of both characteristics. In contrast, a trend toward higher HVR1 dN/dS ratios was detected among those with persistent viremia. We did not detect any such association for factors that may affect complexity such as serum HCV RNA concentration. HVR1 had a lower positive charge in subjects with persistent viremia, although no consistent motifs were detected. Our data suggest that HCV persistence is associated with a complex quasispecies and immune response to HVR1.  (+info)

Long-term follow-up of chimpanzees inoculated with the first infectious clone for hepatitis C virus. (7/5458)

Two chimpanzees (Ch1535 and Ch1536) became infected with hepatitis C virus (HCV) following intrahepatic inoculation with RNA transcribed from a full-length cDNA clone of the virus. Both animals were persistently infected and have been followed for 60 weeks. They showed similar responses to infection, with transient liver enzyme elevations and liver inflammatory responses, which peaked at weeks 17 (Ch1535) and 12 (Ch1536) postinoculation (p.i.). Antibody responses to structural and nonstructural proteins were first detected at weeks 13 (Ch1535) and 10 (Ch1536) p.i. Serum RNA titers increased steadily during the first 10 to 13 weeks but decreased sharply in both animals following antibody and inflammatory responses. Despite direct evidence of humoral immune responses to multiple viral antigens, including hypervariable region 1 (HVR1), both animals remained chronically infected. Detailed sequence analysis of serum HCV RNA revealed no change in the majority HVR1 sequence in Ch1535 and a single-amino-acid mutation in Ch1536, with very little clonal variation in either animal. Full-length genome analysis at week 60 revealed several amino acid substitutions localized to antigens E1, E2, p7, NS3, and NS5. Of these, 55.6 and 40% were present as the majority sequence in serum RNA isolated at week 26 p.i. (Ch1535) and week 22 p.i. (Ch1536), respectively, and could represent immune escape mutations. Mutations accumulated at a rate of 1.57 x 10(-3) and 1.48 x 10(-3) nucleotide substitutions/site/year for Ch1535 and Ch1536, respectively. Taken together, these data indicate that establishment of a persistent HCV infection in these chimpanzees is not due to changes in HVR1; however, the possibility remains that mutations arising in other parts of the genome contributed to this persistence.  (+info)

The natural course of hepatitis C virus infection 18 years after an epidemic outbreak of non-A, non-B hepatitis in a plasmapheresis centre. (8/5458)

BACKGROUND: The natural history of hepatitis C virus (HCV) infection is variable and factors determining the course of the illness are unclear. AIMS: To determine the natural course of HCV infection in a well characterised group of patients 18 years after an epidemic outbreak of non-A, non-B hepatitis at a plasmapheresis centre. METHODS: Between 1994 and 1996, 20 of 30 affected individuals were studied. HCV infection was confirmed using second and third generation ELISA test kits. HCV RNA was detected by a polymerase chain reaction (PCR) method and HCV genotyping was performed by analysing amplicons from the conserved 5'-non-translated region generated by nested PCR. Thirty two liver biopsies were carried out in 14 patients. RESULTS: HCV antibodies were detected in all subjects. Eighteen patients had abnormal liver enzymes and 17 were HCV RNA positive, all of whom were infected with genotype 1a. Ninety per cent of this cohort showed evidence of chronic HCV infection with 50% having progressive liver disease and 20% cirrhosis 18 years after acute onset of non-A, non-B hepatitis. Considerable variation in disease outcome occurred between individuals and no correlation with clinical features of the acute illness was found. CONCLUSIONS: Variability in the consequences of HCV infection in cases infected with the same virus suggests that host factors are important in determining disease outcome. The factors which determine differences in the natural history of the disease still remain to be elucidated.  (+info)

Hepatitis C is a liver infection caused by the hepatitis C virus (HCV). It's primarily spread through contact with contaminated blood, often through sharing needles or other equipment to inject drugs. For some people, hepatitis C is a short-term illness but for most — about 75-85% — it becomes a long-term, chronic infection that can lead to serious health problems like liver damage, liver failure, and even liver cancer. The virus can infect and inflame the liver, causing symptoms like jaundice (yellowing of the skin and eyes), abdominal pain, fatigue, and dark urine. Many people with hepatitis C don't have any symptoms, so they might not know they have the infection until they experience complications. There are effective treatments available for hepatitis C, including antiviral medications that can cure the infection in most people. Regular testing is important to diagnose and treat hepatitis C early, before it causes serious health problems.

Chronic Hepatitis C is a liver infection caused by the hepatitis C virus (HCV) that lasts for more than six months. This long-term infection can lead to scarring of the liver (cirrhosis), which can cause serious health problems, such as liver failure or liver cancer, in some individuals. The infection is usually asymptomatic until complications arise, but it can be detected through blood tests that identify antibodies to the virus or viral RNA. Chronic hepatitis C is typically managed with antiviral therapy, which can help clear the virus from the body and reduce the risk of liver damage.

Hepacivirus is a genus of viruses in the family Flaviviridae. The most well-known member of this genus is Hepatitis C virus (HCV), which is a major cause of liver disease worldwide. HCV infection can lead to chronic hepatitis, cirrhosis, and liver cancer.

Hepaciviruses are enveloped viruses with a single-stranded, positive-sense RNA genome. They have a small icosahedral capsid and infect a variety of hosts, including humans, non-human primates, horses, and birds. The virus enters the host cell by binding to specific receptors on the cell surface and is then internalized through endocytosis.

HCV has a high degree of genetic diversity and is classified into seven major genotypes and numerous subtypes based on differences in its RNA sequence. This genetic variability can affect the virus's ability to evade the host immune response, making treatment more challenging.

In addition to HCV, other hepaciviruses have been identified in various animal species, including equine hepacivirus (EHCV), rodent hepacivirus (RHV), and bat hepacivirus (BtHepCV). These viruses are being studied to better understand the biology of hepaciviruses and their potential impact on human health.

Hepatitis B is a viral infection that attacks the liver and can cause both acute and chronic disease. The virus is transmitted through contact with infected blood, semen, and other bodily fluids. It can also be passed from an infected mother to her baby at birth.

Acute hepatitis B infection lasts for a few weeks to several months and often causes no symptoms. However, some people may experience mild to severe flu-like symptoms, yellowing of the skin and eyes (jaundice), dark urine, and fatigue. Most adults with acute hepatitis B recover completely and develop lifelong immunity to the virus.

Chronic hepatitis B infection can lead to serious liver damage, including cirrhosis and liver cancer. People with chronic hepatitis B may experience long-term symptoms such as fatigue, joint pain, and depression. They are also at risk for developing liver failure and liver cancer.

Prevention measures include vaccination, safe sex practices, avoiding sharing needles or other drug injection equipment, and covering wounds and skin rashes. There is no specific treatment for acute hepatitis B, but chronic hepatitis B can be treated with antiviral medications to slow the progression of liver damage.

Hepatitis A is a viral infection that specifically targets the liver, causing inflammation and impaired function. This disease is caused by the hepatitis A virus (HAV), which spreads primarily through the fecal-oral route, often due to poor sanitation and hygiene. Individuals can become infected by consuming food or water contaminated with HAV or by coming into direct contact with an infected person's stool.

The symptoms of hepatitis A may include fatigue, loss of appetite, nausea, vomiting, abdominal pain, dark urine, clay-colored bowel movements, joint pain, and jaundice (yellowing of the skin and eyes). However, in some cases, particularly in children under six years old, the infection may be asymptomatic.

While hepatitis A can be unpleasant and cause serious complications, it is rarely fatal and most people recover completely within a few months. Preventive measures include vaccination, practicing good hygiene, and avoiding potentially contaminated food and water.

Hepatitis C antibodies are proteins produced by the immune system in response to an infection with the hepatitis C virus (HCV). Detection of these antibodies in the blood indicates a past or present HCV infection. However, it does not necessarily mean that the person is currently infected, as antibodies can persist for years even after the virus has been cleared from the body. Additional tests are usually needed to confirm whether the infection is still active and to guide treatment decisions.

Hepatitis B virus (HBV) is a DNA virus that belongs to the Hepadnaviridae family and causes the infectious disease known as hepatitis B. This virus primarily targets the liver, where it can lead to inflammation and damage of the liver tissue. The infection can range from acute to chronic, with chronic hepatitis B increasing the risk of developing serious liver complications such as cirrhosis and liver cancer.

The Hepatitis B virus has a complex life cycle, involving both nuclear and cytoplasmic phases. It enters hepatocytes (liver cells) via binding to specific receptors and is taken up by endocytosis. The viral DNA is released into the nucleus, where it is converted into a covalently closed circular DNA (cccDNA) form, which serves as the template for viral transcription.

HBV transcribes several RNAs, including pregenomic RNA (pgRNA), which is used as a template for reverse transcription during virion assembly. The pgRNA is encapsidated into core particles along with the viral polymerase and undergoes reverse transcription to generate new viral DNA. This process occurs within the cytoplasm of the hepatocyte, resulting in the formation of immature virions containing partially double-stranded DNA.

These immature virions are then enveloped by host cell membranes containing HBV envelope proteins (known as surface antigens) to form mature virions that can be secreted from the hepatocyte and infect other cells. The virus can also integrate into the host genome, which may contribute to the development of hepatocellular carcinoma in chronic cases.

Hepatitis B is primarily transmitted through exposure to infected blood or bodily fluids containing the virus, such as through sexual contact, sharing needles, or from mother to child during childbirth. Prevention strategies include vaccination, safe sex practices, and avoiding needle-sharing behaviors. Treatment for hepatitis B typically involves antiviral medications that can help suppress viral replication and reduce the risk of liver damage.

Hepatitis B Surface Antigens (HBsAg) are proteins found on the surface of the Hepatitis B virus. They are present in the blood of individuals infected with the Hepatitis B virus and are used as a marker for the presence of a current Hepatitis B infection. The detection of HBsAg in the blood indicates that an individual is infectious and can transmit the virus to others. It is typically used in diagnostic tests to detect and diagnose Hepatitis B infections, monitor treatment response, and assess the risk of transmission.

Antiviral agents are a class of medications that are designed to treat infections caused by viruses. Unlike antibiotics, which target bacteria, antiviral agents interfere with the replication and infection mechanisms of viruses, either by inhibiting their ability to replicate or by modulating the host's immune response to the virus.

Antiviral agents are used to treat a variety of viral infections, including influenza, herpes simplex virus (HSV) infections, human immunodeficiency virus (HIV) infection, hepatitis B and C, and respiratory syncytial virus (RSV) infections.

These medications can be administered orally, intravenously, or topically, depending on the type of viral infection being treated. Some antiviral agents are also used for prophylaxis, or prevention, of certain viral infections.

It is important to note that antiviral agents are not effective against all types of viruses and may have significant side effects. Therefore, it is essential to consult with a healthcare professional before starting any antiviral therapy.

Hepatitis is a medical condition characterized by inflammation of the liver, often resulting in damage to liver cells. It can be caused by various factors, including viral infections (such as Hepatitis A, B, C, D, and E), alcohol abuse, toxins, medications, and autoimmune disorders. Symptoms may include jaundice, fatigue, abdominal pain, loss of appetite, nausea, vomiting, and dark urine. The severity of the disease can range from mild illness to severe, life-threatening conditions, such as liver failure or cirrhosis.

Hepatitis C antigens refer to the proteins present on the surface of the hepatitis C virus (HCV). The most commonly studied and clinically relevant antigen is the core protein, which plays a crucial role in the viral replication process. Detection of HCV antigens in serum or plasma can indicate an ongoing infection, as they appear during the early stages of infection and usually persist until the development of a humoral immune response, which leads to the production of antibodies against these antigens.

The detection of HCV core antigen (HCVcAg) has been used as an alternative diagnostic marker for HCV infection, especially in resource-limited settings where nucleic acid testing (NAT), such as polymerase chain reaction (PCR) for HCV RNA, might not be readily available. However, the sensitivity and specificity of HCVcAg detection are generally lower than those of NAT methods. Nonetheless, it remains a valuable tool in monitoring treatment response and disease progression in individuals with chronic hepatitis C infection.

Viral hepatitis in humans refers to inflammation of the liver caused by infection with viruses that primarily target the liver. There are five main types of human viral hepatitis, designated as Hepatitis A, B, C, D, and E virus (HAV, HBV, HCV, HDV, and HEV). These viruses can cause a range of illnesses, from acute self-limiting hepatitis to chronic hepatitis, which can lead to cirrhosis and liver cancer.

1. Hepatitis A virus (HAV) is typically spread through the fecal-oral route, often through contaminated food or water. It usually results in an acute self-limiting infection, but rarely can cause chronic hepatitis in individuals with weakened immune systems.
2. Hepatitis B virus (HBV) is primarily transmitted through contact with infected blood, semen, and other bodily fluids. It can lead to both acute and chronic hepatitis, which may result in cirrhosis and liver cancer if left untreated.
3. Hepatitis C virus (HCV) is predominantly spread through exposure to infected blood, such as through sharing needles or receiving contaminated blood transfusions. Chronic hepatitis C is common, and it can lead to serious liver complications like cirrhosis and liver cancer if not treated.
4. Hepatitis D virus (HDV) is an incomplete virus that requires the presence of HBV for its replication. HDV infection occurs only in individuals already infected with HBV, leading to more severe liver disease compared to HBV monoinfection.
5. Hepatitis E virus (HEV) is primarily transmitted through the fecal-oral route, often through contaminated food or water. It usually results in an acute self-limiting infection but can cause chronic hepatitis in pregnant women and individuals with weakened immune systems.

Prevention measures include vaccination for HAV and HBV, safe sex practices, avoiding sharing needles, and ensuring proper hygiene and sanitation to prevent fecal-oral transmission.

Chronic Hepatitis B is a persistent infection of the liver caused by the hepatitis B virus (HBV), which can lead to chronic inflammation and scarring of the liver over time. It is defined as the presence of hepatitis B surface antigen (HBsAg) in the blood for more than six months.

The infection can be asymptomatic or may cause nonspecific symptoms such as fatigue, loss of appetite, nausea, and joint pain. A small percentage of people with chronic HBV infection may develop serious complications, including cirrhosis, liver failure, and liver cancer. Treatment options for chronic hepatitis B include antiviral medications that can help to suppress the virus and reduce the risk of liver damage. Vaccination is available to prevent hepatitis B infection.

Hepatitis antibodies are proteins produced by the immune system in response to an infection caused by a hepatitis virus. There are several types of hepatitis viruses, including A, B, C, D, and E, each with their own specific antibodies.

The presence of hepatitis antibodies in the blood can indicate a current or past infection with the corresponding hepatitis virus. For example, the detection of anti-HAV (hepatitis A virus) antibodies indicates a past infection or immunization against hepatitis A, while the detection of anti-HBs (hepatitis B surface antigen) antibodies indicates immunity due to vaccination or recovery from a hepatitis B infection.

It's important to note that some hepatitis antibodies may not provide immunity to future infections, and individuals can still be infected with the virus even if they have previously produced antibodies against it. Therefore, regular testing and vaccination are essential for preventing the spread of hepatitis viruses and protecting public health.

Ribavirin is an antiviral medication used in the treatment of certain viral infections, including hepatitis C and respiratory syncytial virus (RSV) infection. It works by interfering with viral replication, preventing the virus from multiplying within infected cells. Ribavirin is often used in combination with other antiviral drugs for more effective treatment.

It's important to note that ribavirin can have serious side effects and should only be used under the supervision of a healthcare professional. Additionally, it is not effective against all types of viral infections and its use should be based on a confirmed diagnosis and appropriate medical evaluation.

Hepatitis A virus (HAV) is the causative agent of hepatitis A, a viral infection that causes inflammation of the liver. It is a small, non-enveloped, single-stranded RNA virus belonging to the Picornaviridae family and Hepatovirus genus. The virus primarily spreads through the fecal-oral route, often through contaminated food or water, or close contact with an infected person. After entering the body, HAV infects hepatocytes in the liver, leading to liver damage and associated symptoms such as jaundice, fatigue, abdominal pain, and nausea. The immune system eventually clears the infection, providing lifelong immunity against future HAV infections. Preventive measures include vaccination and practicing good hygiene to prevent transmission.

Hepatitis B antibodies are proteins produced by the immune system in response to the presence of the Hepatitis B virus. There are two main types of Hepatitis B antibodies:

1. Hepatitis B surface antibody (anti-HBs): This is produced when a person has recovered from a Hepatitis B infection or has been successfully vaccinated against the virus. The presence of anti-HBs indicates immunity to Hepatitis B.
2. Hepatitis B core antibody (anti-HBC): This is produced during a Hepatitis B infection and remains present for life, even after the infection has been cleared. However, the presence of anti-HBC alone does not indicate immunity to Hepatitis B, as it can also be present in people who have a chronic Hepatitis B infection.

It's important to note that testing for Hepatitis B antibodies is typically done through blood tests and can help determine whether a person has been infected with the virus, has recovered from an infection, or has been vaccinated against it.

Chronic hepatitis is a type of liver inflammation that lasts for more than six months and can lead to scarring of the liver (cirrhosis), liver failure, and even liver cancer in some cases. It can be caused by various factors, including viral infections such as Hepatitis B and C, autoimmune disorders, alcohol abuse, and non-alcoholic fatty liver disease. The symptoms of chronic hepatitis may include fatigue, loss of appetite, nausea, vomiting, abdominal pain, joint pain, dark urine, and jaundice (yellowing of the skin and eyes). Treatment for chronic hepatitis depends on the underlying cause and may include antiviral medications, immunosuppressive drugs, or lifestyle changes.

Interferon-alpha (IFN-α) is a type I interferon, which is a group of signaling proteins made and released by host cells in response to the presence of viruses, parasites, and tumor cells. It plays a crucial role in the immune response against viral infections. IFN-α has antiviral, immunomodulatory, and anti-proliferative effects.

IFN-α is produced naturally by various cell types, including leukocytes (white blood cells), fibroblasts, and epithelial cells, in response to viral or bacterial stimulation. It binds to specific receptors on the surface of nearby cells, triggering a signaling cascade that leads to the activation of genes involved in the antiviral response. This results in the production of proteins that inhibit viral replication and promote the presentation of viral antigens to the immune system, enhancing its ability to recognize and eliminate infected cells.

In addition to its role in the immune response, IFN-α has been used as a therapeutic agent for various medical conditions, including certain types of cancer, chronic hepatitis B and C, and multiple sclerosis. However, its use is often limited by side effects such as flu-like symptoms, depression, and neuropsychiatric disorders.

"Hepatitis B vaccines are vaccines that prevent infection caused by the hepatitis B virus. They work by introducing a small and harmless piece of the virus to your body, which triggers your immune system to produce antibodies to fight off the infection. These antibodies remain in your body and provide protection if you are exposed to the real hepatitis B virus in the future.

The hepatitis B vaccine is typically given as a series of three shots over a six-month period. It is recommended for all infants, children and adolescents who have not previously been vaccinated, as well as for adults who are at increased risk of infection, such as healthcare workers, people who inject drugs, and those with certain medical conditions.

It's important to note that hepatitis B vaccine does not provide protection against other types of viral hepatitis, such as hepatitis A or C."

A viral RNA (ribonucleic acid) is the genetic material found in certain types of viruses, as opposed to viruses that contain DNA (deoxyribonucleic acid). These viruses are known as RNA viruses. The RNA can be single-stranded or double-stranded and can exist as several different forms, such as positive-sense, negative-sense, or ambisense RNA. Upon infecting a host cell, the viral RNA uses the host's cellular machinery to translate the genetic information into proteins, leading to the production of new virus particles and the continuation of the viral life cycle. Examples of human diseases caused by RNA viruses include influenza, COVID-19 (SARS-CoV-2), hepatitis C, and polio.

Viral nonstructural proteins (NS) are viral proteins that are not part of the virion structure. They play various roles in the viral life cycle, such as replication of the viral genome, transcription, translation regulation, and modulation of the host cell environment to favor virus replication. These proteins are often produced in large quantities during infection and can manipulate or disrupt various cellular pathways to benefit the virus. They may also be involved in evasion of the host's immune response. The specific functions of viral nonstructural proteins vary depending on the type of virus.

Hepatitis B core antigen (HBcAg) is a protein found in the core of the hepatitis B virus (HBV). It is present during active replication of the virus and plays a crucial role in the formation of the viral capsid or core. The antibodies produced against HBcAg (anti-HBc) can be detected in the blood, which serves as a marker for current or past HBV infection. It is important to note that HBcAg itself is not detectable in the blood because it is confined within the viral particle. However, during the serological testing of hepatitis B, the detection of anti-HBc IgM indicates a recent acute infection, while the presence of anti-HBc IgG suggests either a past resolved infection or an ongoing chronic infection.

Hepatitis A vaccines are inactivated or live attenuated viral vaccines that are administered to prevent infection and illness caused by the hepatitis A virus. The vaccine contains antigens that stimulate an immune response in the body, leading to the production of antibodies that protect against future infection with the virus.

The inactivated hepatitis A vaccine is made from viruses that have been chemically treated to destroy their ability to cause disease while preserving their ability to stimulate an immune response. This type of vaccine is typically given in two doses, six months apart, and provides long-term protection against the virus.

The live attenuated hepatitis A vaccine contains a weakened form of the virus that is unable to cause illness but can still stimulate an immune response. This type of vaccine is given as a single dose and provides protection against the virus for at least 20 years.

Hepatitis A vaccines are recommended for people who are at increased risk of infection, including travelers to areas where hepatitis A is common, men who have sex with men, people who use injection drugs, and people with chronic liver disease or clotting factor disorders. The vaccine is also recommended for children in certain states and communities where hepatitis A is endemic.

Hepatitis B e antigen (HBeAg) is a protein produced by the hepatitis B virus (HBV) during its replication process. It can be found in the blood of individuals infected with HBV. The presence of HBeAg generally indicates that the virus is actively replicating in the liver and that the individual has high levels of viral load.

HBeAg is a serological marker used to assess the severity and activity of HBV infection, as well as the response to antiviral treatment. In particular, the disappearance of HBeAg from the blood (known as seroconversion) is often associated with a decrease in viral replication and an improvement in liver disease. However, the presence of HBeAg does not necessarily mean that the individual will develop symptoms or liver damage, as some people can remain asymptomatic carriers of the virus for many years.

It's important to note that not all HBV strains produce HBeAg, and some mutant strains may not produce detectable levels of this antigen even when the virus is actively replicating. Therefore, additional tests may be needed to confirm the presence or absence of HBV infection in these cases.

Liver cirrhosis is a chronic, progressive disease characterized by the replacement of normal liver tissue with scarred (fibrotic) tissue, leading to loss of function. The scarring is caused by long-term damage from various sources such as hepatitis, alcohol abuse, nonalcoholic fatty liver disease, and other causes. As the disease advances, it can lead to complications like portal hypertension, fluid accumulation in the abdomen (ascites), impaired brain function (hepatic encephalopathy), and increased risk of liver cancer. It is generally irreversible, but early detection and treatment of underlying causes may help slow down its progression.

Viral hepatitis vaccines are vaccines that prevent infection caused by various hepatitis viruses, including hepatitis A and B. These vaccines contain antigens that stimulate the immune system to produce antibodies that protect against infection with the corresponding virus. The vaccines are typically administered through injection and may require multiple doses for full protection.

The hepatitis A vaccine is made from inactivated hepatitis A virus, while the hepatitis B vaccine is made from recombinant hepatitis B surface antigen. Both vaccines have been shown to be highly effective in preventing infection and reducing the risk of complications associated with viral hepatitis, such as liver disease and liver cancer.

It's important to note that there are no vaccines available for other types of viral hepatitis, such as hepatitis C, D, or E. Prevention strategies for these types of viral hepatitis typically involve measures to reduce exposure to the virus, such as safe injection practices and avoiding high-risk behaviors like sharing needles or having unprotected sex with infected individuals.

Hepatitis B antigens are proteins or particles present on the surface (HBsAg) or inside (HBcAg, HBeAg) the hepatitis B virus.

1. HBsAg (Hepatitis B surface antigen): This is a protein found on the outer surface of the hepatitis B virus. Its presence in the blood indicates an active infection with hepatitis B virus. It's also used as a marker to diagnose hepatitis B infection and monitor treatment response.

2. HBcAg (Hepatitis B core antigen): This is a protein found inside the hepatitis B virus core. It's not usually detected in the blood, but its antibodies (anti-HBc) are used to diagnose past or present hepatitis B infection.

3. HBeAg (Hepatitis B e antigen): This is a protein found inside the hepatitis B virus core and is associated with viral replication. Its presence in the blood indicates high levels of viral replication, increased infectivity, and higher risk of liver damage. It's used to monitor disease progression and treatment response.

These antigens play a crucial role in the diagnosis, management, and prevention of hepatitis B infection.

Hepatitis E is a viral infection that specifically affects the liver, caused by the hepatitis E virus (HEV). The disease is primarily transmitted through the fecal-oral route, often through contaminated water or food. It can also be spread through blood transfusions and vertical transmission from mother to fetus.

The incubation period for hepatitis E ranges from 2 to 10 weeks. Symptoms of the disease are similar to other types of viral hepatitis and may include jaundice (yellowing of the skin and eyes), fatigue, loss of appetite, abdominal pain, nausea, vomiting, joint pain, and dark urine.

In most cases, hepatitis E is a self-limiting disease, meaning that it resolves on its own within a few weeks to months. However, in some individuals, particularly those with weakened immune systems, the infection can lead to severe complications such as acute liver failure and death. Pregnant women, especially those in the third trimester, are at higher risk of developing severe disease and have a mortality rate of up to 25%.

Prevention measures include maintaining good hygiene practices, practicing safe food handling and preparation, and ensuring access to clean water sources. Currently, there is no specific treatment for hepatitis E, but supportive care can help manage symptoms. Vaccines are available in some countries to prevent the disease.

Polyethylene glycols (PEGs) are a family of synthetic, water-soluble polymers with a wide range of molecular weights. They are commonly used in the medical field as excipients in pharmaceutical formulations due to their ability to improve drug solubility, stability, and bioavailability. PEGs can also be used as laxatives to treat constipation or as bowel cleansing agents prior to colonoscopy examinations. Additionally, some PEG-conjugated drugs have been developed for use in targeted cancer therapies.

In a medical context, PEGs are often referred to by their average molecular weight, such as PEG 300, PEG 400, PEG 1500, and so on. Higher molecular weight PEGs tend to be more viscous and have longer-lasting effects in the body.

It's worth noting that while PEGs are generally considered safe for use in medical applications, some people may experience allergic reactions or hypersensitivity to these compounds. Prolonged exposure to high molecular weight PEGs has also been linked to potential adverse effects, such as decreased fertility and developmental toxicity in animal studies. However, more research is needed to fully understand the long-term safety of PEGs in humans.

Autoimmune hepatitis is a chronic (long-term) disease in which the body's immune system mistakenly attacks the liver, leading to inflammation and damage. This results in decreased liver function over time if not treated. The exact cause of autoimmune hepatitis is unknown, but it is believed to be associated with genetic factors and exposure to certain environmental triggers, such as viral infections or medications.

There are two main types of autoimmune hepatitis:

1. Type 1 (classic) autoimmune hepatitis: This form can affect both adults and children, and it is more common in women than men. People with this type may also have other autoimmune disorders, such as rheumatoid arthritis, thyroid disease, or ulcerative colitis.
2. Type 2 autoimmune hepatitis: This form primarily affects children and young women. It is less common than type 1 and tends to be more severe. People with this type may also have other autoimmune disorders, such as celiac disease or chronic candidiasis.

Symptoms of autoimmune hepatitis can vary widely, from mild to severe. They may include fatigue, loss of appetite, nausea, vomiting, abdominal pain, joint pain, jaundice (yellowing of the skin and eyes), dark urine, and light-colored stools.

Diagnosis typically involves blood tests, imaging studies, and sometimes a liver biopsy to assess the extent of damage. Treatment usually includes medications that suppress the immune system, such as corticosteroids and immunosuppressants, which can help reduce inflammation and slow or stop liver damage. In some cases, lifestyle changes and supportive care may also be necessary.

Hepatitis E virus (HEV) is a single-stranded, positive-sense RNA virus that belongs to the family Hepeviridae and genus Orthohepevirus. It primarily infects the liver, causing acute hepatitis in humans. The virus is transmitted through the fecal-oral route, often through contaminated water or food sources. Ingestion of raw or undercooked pork or deer meat can also lead to HEV infection.

HEV infection typically results in self-limiting acute hepatitis, characterized by symptoms such as jaundice, fatigue, loss of appetite, abdominal pain, and dark urine. In some cases, particularly among pregnant women and individuals with weakened immune systems, HEV infection can lead to severe complications, including fulminant hepatic failure and death.

There are four main genotypes of HEV that infect humans: genotype 1 and 2 are primarily found in developing countries and are transmitted through contaminated water; genotype 3 and 4 are found worldwide and can be transmitted through both zoonotic and human-to-human routes.

Prevention measures include improving sanitation, access to clean water, and food safety practices. Currently, there is no specific antiviral treatment for HEV infection, but supportive care can help manage symptoms. A vaccine against HEV is available in China and has shown efficacy in preventing the disease.

I'm sorry for any confusion, but "Viral Hepatitis, Animal" is not a standard medical classification or definition. Hepatitis refers to inflammation of the liver, and viral hepatitis refers to inflammation caused by a virus. The term "animal" in this context doesn't provide a clear meaning.

However, it's worth noting that some animals can contract viral hepatitis, similar to humans. For instance, there are hepatitis A, B, and C-like viruses that have been identified in various animal species. These are typically not transmissible to humans.

If you're referring to a specific medical condition or context, could you please provide more details? I'd be happy to help further with more information.

Hepatitis A antibodies are proteins produced by the immune system in response to a Hepatitis A virus infection or after vaccination. There are two types of Hepatitis A antibodies:

1. IgM anti-HAV (Hepatitis A Virus) antibodies: These are the first type of antibodies produced by the immune system during a Hepatitis A infection. They appear in the blood within 2 to 4 weeks after exposure to the virus and remain detectable for up to 12 weeks. The presence of IgM anti-HAV antibodies indicates a recent or ongoing Hepatitis A infection.

2. IgG anti-HAV antibodies: These are the second type of antibodies produced by the immune system during a Hepatitis A infection, and they appear in the blood several weeks after the onset of illness. IgG anti-HAV antibodies remain detectable for many years, providing long-term immunity against future Hepatitis A infections. After vaccination, only IgG anti-HAV antibodies are produced, indicating immunity to Hepatitis A.

Testing for Hepatitis A antibodies is used to diagnose acute or past Hepatitis A infections and to assess immunity following vaccination.

Hepatitis viruses refer to a group of viral agents that primarily target the liver, causing inflammation and damage to hepatocytes (liver cells). This results in various clinical manifestations, ranging from an acute infection to a chronic, persistent infection. There are five main types of hepatitis viruses, named Hepatitis A, B, C, D, and E virus, each with distinct genetic material, modes of transmission, and disease severity.

1. Hepatitis A Virus (HAV): This is a single-stranded RNA virus that is primarily transmitted through the fecal-oral route, often via contaminated food or water. Infected individuals may experience symptoms such as jaundice, fatigue, abdominal pain, and loss of appetite. While most people recover completely within a few months, severe complications can occur in rare cases. A vaccine is available to prevent HAV infection.
2. Hepatitis B Virus (HBV): This is a double-stranded DNA virus that is primarily transmitted through contact with infected blood or bodily fluids, such as during sexual contact, sharing needles, or from mother to child during childbirth. HBV can cause both acute and chronic hepatitis, which may lead to severe liver complications like cirrhosis and liver cancer if left untreated. A vaccine is available to prevent HBV infection.
3. Hepatitis C Virus (HCV): This is a single-stranded RNA virus that is primarily transmitted through contact with infected blood, often through sharing needles or during medical procedures using contaminated equipment. Like HBV, HCV can cause both acute and chronic hepatitis, which may lead to severe liver complications if left untreated. No vaccine is currently available for HCV; however, antiviral treatments can cure the infection in many cases.
4. Hepatitis D Virus (HDV): This is a defective RNA virus that requires the presence of HBV to replicate and cause infection. HDV is primarily transmitted through contact with infected blood or bodily fluids, similar to HBV. Co-infection with both HBV and HDV can result in more severe liver disease compared to HBV infection alone. Antiviral treatments are available for HDV; however, a vaccine is not.
5. Hepatitis E Virus (HEV): This is a single-stranded RNA virus that primarily causes acute hepatitis and is usually transmitted through the fecal-oral route, often through contaminated food or water. In most cases, HEV infection resolves on its own without treatment. However, in pregnant women and individuals with weakened immune systems, HEV can cause severe liver complications. No vaccine is currently available for HEV in the United States; however, a vaccine has been approved in some countries.

Hepatitis A Virus, Human (HAV): A single-stranded, positive-sense RNA virus belonging to the Picornaviridae family, specifically the Hepatovirus genus. It is the causative agent of Hepatitis A, a viral infection that primarily affects the liver. The virus is typically transmitted through the fecal-oral route, often via contaminated food or water, or close contact with an infected individual. Following incubation (15-50 days), symptoms may include jaundice, fatigue, abdominal pain, loss of appetite, nausea, diarrhea, and fever. Most people recover completely within a few weeks; however, severe complications and death are possible, especially in individuals with preexisting liver disease. Prevention is primarily achieved through vaccination and practicing good hygiene.

Viral core proteins are the structural proteins that make up the viral capsid or protein shell, enclosing and protecting the viral genome. These proteins play a crucial role in the assembly of the virion, assist in the infection process by helping to deliver the viral genome into the host cell, and may also have functions in regulating viral replication. The specific composition and structure of viral core proteins vary among different types of viruses.

Hepatitis D, also known as Delta hepatitis, is a viral infection of the liver that can only occur in people who have a current infection with the hepatitis B virus (HBV). It's caused by the hepatitis delta virus (HDV), which is a small, enveloped, single-stranded RNA virus.

HDV requires the presence of HBV for its replication and survival, so it can't infect someone who doesn't already have HBV. When both viruses are present, they can interact in ways that lead to more severe liver disease than either virus would cause alone.

Hepatitis D can be an acute or chronic infection, and it can range from mild to severe, with symptoms similar to those of other types of viral hepatitis, such as jaundice, fatigue, loss of appetite, nausea, vomiting, abdominal pain, and joint pain. In some cases, hepatitis D can lead to serious complications, including liver failure and death.

Hepatitis D is primarily spread through contact with infected blood or other bodily fluids, such as during sexual contact, sharing needles, or mother-to-child transmission during childbirth. It's preventable through vaccination against hepatitis B, which provides immunity to both viruses. There is no specific treatment for hepatitis D, but antiviral therapy for hepatitis B can help manage the infection and prevent complications.

Hepatitis Delta Virus (HDV) is not a traditional virus but rather a defective RNA particle that requires the assistance of the hepatitis B virus (HBV) to replicate. It's also known as delta agent or hepatitis D. HDV is a unique pathogen that only infects individuals who are already infected with HBV.

The virus causes a more severe form of viral hepatitis than HBV alone, leading to a higher risk of fulminant hepatitis (acute liver failure) and chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma. HDV is primarily transmitted through percutaneous or sexual contact with infected blood or body fluids.

Prevention strategies include vaccination against HBV, which also prevents HDV infection, and avoiding high-risk behaviors such as intravenous drug use and unprotected sex with multiple partners. There is no specific treatment for HDV; however, antiviral therapy for HBV can help manage the infection.

I'm sorry for any confusion, but "Animal Hepatitis" is not a medical term used to describe a specific disease. Hepatitis refers to inflammation of the liver, and it can be caused by various factors, including viruses, alcohol, drugs, and certain medical conditions.

However, there are several viral hepatitis types that can infect animals, such as Hepatitis A, B, and C, which primarily affect humans. But there are also other hepatitis viruses that are species-specific and primarily infect animals, such as:

1. Canine Hepatitis (Adenovirus Type 1): This is a viral infection that affects dogs and causes liver damage, respiratory signs, and occasionally death.
2. Feline Infectious Peritonitis (FIP) Virus: While not strictly a hepatitis virus, this feline coronavirus can cause severe inflammation of the liver and other organs in cats.
3. Equine Infectious Anemia Virus (EIAV): This retrovirus affects horses and causes cyclic fever, anemia, and occasionally liver disease.
4. Avian Hepatitis E Virus: A recently discovered virus that infects birds and can cause hepatitis and other systemic signs in chickens and other avian species.

If you're looking for information on a specific animal hepatitis virus or a different medical term, please provide more context so I can give you a more accurate answer.

Alanine transaminase (ALT) is a type of enzyme found primarily in the cells of the liver and, to a lesser extent, in the cells of other tissues such as the heart, muscles, and kidneys. Its primary function is to catalyze the reversible transfer of an amino group from alanine to another alpha-keto acid, usually pyruvate, to form pyruvate and another amino acid, usually glutamate. This process is known as the transamination reaction.

When liver cells are damaged or destroyed due to various reasons such as hepatitis, alcohol abuse, nonalcoholic fatty liver disease, or drug-induced liver injury, ALT is released into the bloodstream. Therefore, measuring the level of ALT in the blood is a useful diagnostic tool for evaluating liver function and detecting liver damage. Normal ALT levels vary depending on the laboratory, but typically range from 7 to 56 units per liter (U/L) for men and 6 to 45 U/L for women. Elevated ALT levels may indicate liver injury or disease, although other factors such as muscle damage or heart disease can also cause elevations in ALT.

Genotype, in genetics, refers to the complete heritable genetic makeup of an individual organism, including all of its genes. It is the set of instructions contained in an organism's DNA for the development and function of that organism. The genotype is the basis for an individual's inherited traits, and it can be contrasted with an individual's phenotype, which refers to the observable physical or biochemical characteristics of an organism that result from the expression of its genes in combination with environmental influences.

It is important to note that an individual's genotype is not necessarily identical to their genetic sequence. Some genes have multiple forms called alleles, and an individual may inherit different alleles for a given gene from each parent. The combination of alleles that an individual inherits for a particular gene is known as their genotype for that gene.

Understanding an individual's genotype can provide important information about their susceptibility to certain diseases, their response to drugs and other treatments, and their risk of passing on inherited genetic disorders to their offspring.

The liver is a large, solid organ located in the upper right portion of the abdomen, beneath the diaphragm and above the stomach. It plays a vital role in several bodily functions, including:

1. Metabolism: The liver helps to metabolize carbohydrates, fats, and proteins from the food we eat into energy and nutrients that our bodies can use.
2. Detoxification: The liver detoxifies harmful substances in the body by breaking them down into less toxic forms or excreting them through bile.
3. Synthesis: The liver synthesizes important proteins, such as albumin and clotting factors, that are necessary for proper bodily function.
4. Storage: The liver stores glucose, vitamins, and minerals that can be released when the body needs them.
5. Bile production: The liver produces bile, a digestive juice that helps to break down fats in the small intestine.
6. Immune function: The liver plays a role in the immune system by filtering out bacteria and other harmful substances from the blood.

Overall, the liver is an essential organ that plays a critical role in maintaining overall health and well-being.

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults. It originates from the hepatocytes, which are the main functional cells of the liver. This type of cancer is often associated with chronic liver diseases such as cirrhosis caused by hepatitis B or C virus infection, alcohol abuse, non-alcoholic fatty liver disease (NAFLD), and aflatoxin exposure.

The symptoms of HCC can vary but may include unexplained weight loss, lack of appetite, abdominal pain or swelling, jaundice, and fatigue. The diagnosis of HCC typically involves imaging tests such as ultrasound, CT scan, or MRI, as well as blood tests to measure alpha-fetoprotein (AFP) levels. Treatment options for Hepatocellular carcinoma depend on the stage and extent of the cancer, as well as the patient's overall health and liver function. Treatment options may include surgery, radiation therapy, chemotherapy, targeted therapy, or liver transplantation.

Virus replication is the process by which a virus produces copies or reproduces itself inside a host cell. This involves several steps:

1. Attachment: The virus attaches to a specific receptor on the surface of the host cell.
2. Penetration: The viral genetic material enters the host cell, either by invagination of the cell membrane or endocytosis.
3. Uncoating: The viral genetic material is released from its protective coat (capsid) inside the host cell.
4. Replication: The viral genetic material uses the host cell's machinery to produce new viral components, such as proteins and nucleic acids.
5. Assembly: The newly synthesized viral components are assembled into new virus particles.
6. Release: The newly formed viruses are released from the host cell, often through lysis (breaking) of the cell membrane or by budding off the cell membrane.

The specific mechanisms and details of virus replication can vary depending on the type of virus. Some viruses, such as DNA viruses, use the host cell's DNA polymerase to replicate their genetic material, while others, such as RNA viruses, use their own RNA-dependent RNA polymerase or reverse transcriptase enzymes. Understanding the process of virus replication is important for developing antiviral therapies and vaccines.

I'm sorry for any confusion, but "replicon" is not a term that has a widely accepted or specific medical definition. It is a term that is used in the field of molecular biology, where it refers to a segment of DNA that contains an origin of replication. The origin of replication is the site on the DNA molecule where the process of DNA replication is initiated. This concept is important in the fields of genetics and virology, but it is not a term that is commonly used in clinical medicine.

If you have any questions related to the medical field, I would be happy to try to help answer them for you!

Viral load refers to the amount or quantity of virus (like HIV, Hepatitis C, SARS-CoV-2) present in an individual's blood or bodily fluids. It is often expressed as the number of virus copies per milliliter of blood or fluid. Monitoring viral load is important in managing and treating certain viral infections, as a higher viral load may indicate increased infectivity, disease progression, or response to treatment.

Murine hepatitis virus (MHV) is a type of coronavirus that primarily infects laboratory mice. It is not related to the human hepatitis viruses A, B, C, D, or E. MHV causes a range of diseases in mice, including hepatitis (liver inflammation), encephalomyelitis (inflammation of the brain and spinal cord), and enteritis (inflammation of the intestine). The virus is transmitted through fecal-oral route and respiratory droplets. It's widely used in research to understand the pathogenesis, immunity, and molecular biology of coronaviruses.

Recombinant proteins are artificially created proteins produced through the use of recombinant DNA technology. This process involves combining DNA molecules from different sources to create a new set of genes that encode for a specific protein. The resulting recombinant protein can then be expressed, purified, and used for various applications in research, medicine, and industry.

Recombinant proteins are widely used in biomedical research to study protein function, structure, and interactions. They are also used in the development of diagnostic tests, vaccines, and therapeutic drugs. For example, recombinant insulin is a common treatment for diabetes, while recombinant human growth hormone is used to treat growth disorders.

The production of recombinant proteins typically involves the use of host cells, such as bacteria, yeast, or mammalian cells, which are engineered to express the desired protein. The host cells are transformed with a plasmid vector containing the gene of interest, along with regulatory elements that control its expression. Once the host cells are cultured and the protein is expressed, it can be purified using various chromatography techniques.

Overall, recombinant proteins have revolutionized many areas of biology and medicine, enabling researchers to study and manipulate proteins in ways that were previously impossible.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

Liver neoplasms refer to abnormal growths in the liver that can be benign or malignant. Benign liver neoplasms are non-cancerous tumors that do not spread to other parts of the body, while malignant liver neoplasms are cancerous tumors that can invade and destroy surrounding tissue and spread to other organs.

Liver neoplasms can be primary, meaning they originate in the liver, or secondary, meaning they have metastasized (spread) to the liver from another part of the body. Primary liver neoplasms can be further classified into different types based on their cell of origin and behavior, including hepatocellular carcinoma, cholangiocarcinoma, and hepatic hemangioma.

The diagnosis of liver neoplasms typically involves a combination of imaging studies, such as ultrasound, CT scan, or MRI, and biopsy to confirm the type and stage of the tumor. Treatment options depend on the type and extent of the neoplasm and may include surgery, radiation therapy, chemotherapy, or liver transplantation.

Liver transplantation is a surgical procedure in which a diseased or failing liver is replaced with a healthy one from a deceased donor or, less commonly, a portion of a liver from a living donor. The goal of the procedure is to restore normal liver function and improve the patient's overall health and quality of life.

Liver transplantation may be recommended for individuals with end-stage liver disease, acute liver failure, certain genetic liver disorders, or liver cancers that cannot be treated effectively with other therapies. The procedure involves complex surgery to remove the diseased liver and implant the new one, followed by a period of recovery and close medical monitoring to ensure proper function and minimize the risk of complications.

The success of liver transplantation has improved significantly in recent years due to advances in surgical techniques, immunosuppressive medications, and post-transplant care. However, it remains a major operation with significant risks and challenges, including the need for lifelong immunosuppression to prevent rejection of the new liver, as well as potential complications such as infection, bleeding, and organ failure.

Combination drug therapy is a treatment approach that involves the use of multiple medications with different mechanisms of action to achieve better therapeutic outcomes. This approach is often used in the management of complex medical conditions such as cancer, HIV/AIDS, and cardiovascular diseases. The goal of combination drug therapy is to improve efficacy, reduce the risk of drug resistance, decrease the likelihood of adverse effects, and enhance the overall quality of life for patients.

In combining drugs, healthcare providers aim to target various pathways involved in the disease process, which may help to:

1. Increase the effectiveness of treatment by attacking the disease from multiple angles.
2. Decrease the dosage of individual medications, reducing the risk and severity of side effects.
3. Slow down or prevent the development of drug resistance, a common problem in chronic diseases like HIV/AIDS and cancer.
4. Improve patient compliance by simplifying dosing schedules and reducing pill burden.

Examples of combination drug therapy include:

1. Antiretroviral therapy (ART) for HIV treatment, which typically involves three or more drugs from different classes to suppress viral replication and prevent the development of drug resistance.
2. Chemotherapy regimens for cancer treatment, where multiple cytotoxic agents are used to target various stages of the cell cycle and reduce the likelihood of tumor cells developing resistance.
3. Cardiovascular disease management, which may involve combining medications such as angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, diuretics, and statins to control blood pressure, heart rate, fluid balance, and cholesterol levels.
4. Treatment of tuberculosis, which often involves a combination of several antibiotics to target different aspects of the bacterial life cycle and prevent the development of drug-resistant strains.

When prescribing combination drug therapy, healthcare providers must carefully consider factors such as potential drug interactions, dosing schedules, adverse effects, and contraindications to ensure safe and effective treatment. Regular monitoring of patients is essential to assess treatment response, manage side effects, and adjust the treatment plan as needed.

Cryoglobulinemia is a medical condition characterized by the presence of abnormal proteins called cryoglobulins in the blood. These proteins become insoluble at lower temperatures and can form immune complexes that can cause inflammation and damage to small blood vessels when they precipitate in cooler parts of the body.

Cryoglobulinemia is often associated with underlying conditions such as autoimmune diseases (such as rheumatoid arthritis or lupus), chronic infections (such as hepatitis C), and certain types of cancer (such as lymphoma). Symptoms can vary widely, but may include purpura (purple spots on the skin), joint pain, peripheral neuropathy (nerve damage causing numbness or weakness), fatigue, and kidney problems.

The diagnosis of cryoglobulinemia is typically made by detecting cryoglobulins in the blood through a special test that requires the blood sample to be kept at cold temperatures. Treatment for cryoglobulinemia depends on the underlying cause, but may include medications such as corticosteroids, immunosuppressants, or chemotherapy drugs.

CD81 is a type of protein that is found on the surface of certain cells in the human body. It is a member of the tetraspanin family of proteins, which are involved in various cellular processes including cell adhesion, motility, and activation. CD81 has been shown to be important in the function of the immune system, particularly in the regulation of T cells.

CD81 is also known as a potential antigen, which means that it can stimulate an immune response when introduced into the body. Specifically, CD81 can bind to another protein called CD19, and this interaction has been shown to be important for the activation and survival of B cells, which are a type of white blood cell involved in the production of antibodies.

In some cases, CD81 may be targeted by the immune system in certain autoimmune diseases or during rejection of transplanted organs. Additionally, CD81 has been identified as a potential target for cancer immunotherapy, as it is overexpressed on some types of cancer cells and can help to inhibit the anti-tumor immune response.

Substance abuse, intravenous, refers to the harmful or hazardous use of psychoactive substances that are introduced directly into the bloodstream through injection, for non-medical purposes. This behavior can lead to a range of short- and long-term health consequences, including addiction, dependence, and an increased risk of infectious diseases such as HIV and hepatitis C. Intravenous substance abuse often involves drugs such as heroin, cocaine, and amphetamines, and is characterized by the repeated injection of these substances using needles and syringes. The practice can also have serious social consequences, including disrupted family relationships, lost productivity, and criminal behavior.

Hepatovirus is a genus of viruses in the Picornaviridae family, and it's most notably represented by the Human Hepatitis A Virus (HAV). These viruses are non-enveloped, with a single-stranded, positive-sense RNA genome. They primarily infect hepatocytes, causing liver inflammation and disease, such as hepatitis. Transmission of hepatoviruses typically occurs through the fecal-oral route, often via contaminated food or water. The virus causes an acute infection that does not usually become chronic, and recovery is usually complete within a few weeks. Immunity after infection is solid and lifelong.

Hepatocytes are the predominant type of cells in the liver, accounting for about 80% of its cytoplasmic mass. They play a key role in protein synthesis, protein storage, transformation of carbohydrates, synthesis of cholesterol, bile salts and phospholipids, detoxification, modification, and excretion of exogenous and endogenous substances, initiation of formation and secretion of bile, and enzyme production. Hepatocytes are essential for the maintenance of homeostasis in the body.

Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They belong to the larger family of cytokines and are crucial for the innate immune system's defense against infections. Interferons exist in multiple forms, classified into three types: type I (alpha and beta), type II (gamma), and type III (lambda). These proteins play a significant role in modulating the immune response, inhibiting viral replication, regulating cell growth, and promoting apoptosis of infected cells. Interferons are used as therapeutic agents for various medical conditions, including certain viral infections, cancers, and autoimmune diseases.

Viral DNA refers to the genetic material present in viruses that consist of DNA as their core component. Deoxyribonucleic acid (DNA) is one of the two types of nucleic acids that are responsible for storing and transmitting genetic information in living organisms. Viruses are infectious agents much smaller than bacteria that can only replicate inside the cells of other organisms, called hosts.

Viral DNA can be double-stranded (dsDNA) or single-stranded (ssDNA), depending on the type of virus. Double-stranded DNA viruses have a genome made up of two complementary strands of DNA, while single-stranded DNA viruses contain only one strand of DNA.

Examples of dsDNA viruses include Adenoviruses, Herpesviruses, and Poxviruses, while ssDNA viruses include Parvoviruses and Circoviruses. Viral DNA plays a crucial role in the replication cycle of the virus, encoding for various proteins necessary for its multiplication and survival within the host cell.

Hepatitis antigens are proteins or molecules present on the surface or inside the hepatitis viruses (hepatitis A, B, C, D, and E) that can stimulate an immune response in the body. These antigens are targeted by the immune system to produce antibodies to fight against the infection.

For example, the Hepatitis B surface antigen (HBsAg) is a protein found on the surface of the hepatitis B virus and its presence in the blood indicates an ongoing infection or evidence of past infection/vaccination. Similarly, the core antigen (HBcAg) is a protein found inside the hepatitis B virus and is a marker of active viral replication.

Detection of these antigens in clinical samples such as blood is useful for diagnosing hepatitis infections and monitoring the effectiveness of treatment.

Hepatitis A antigens refer to the proteins or molecules present on the surface of the Hepatitis A virus (HAV) that can stimulate an immune response in the body. There are two main types of HAV antigens:

1. Hepatitis A Virus Capsid Antigen (also known as HAV VP1): This is a structural protein that makes up the outer shell or capsid of the HAV particle. It contains several epitopes (regions that can be recognized by the immune system) that can induce the production of antibodies in infected individuals.
2. Hepatitis A Virus Non-structural Antigen (also known as HAV NS1): This is a non-structural protein produced during the replication of the HAV genome. It plays a crucial role in the replication and assembly of new HAV particles, but it is not present in the mature virion. However, its detection in serum or liver tissue can indicate an ongoing HAV infection.

The presence of antibodies against these antigens (anti-HAV antibodies) in a person's blood can be used to diagnose past or recent Hepatitis A infections and immunity acquired through vaccination.

Alcoholic hepatitis is a medical condition characterized by inflammation and damage to the liver caused by excessive alcohol consumption. It is a type of hepatitis that specifically results from alcohol abuse, rather than from viral infections or other causes. The condition can vary in severity, and long-term heavy drinking increases the risk of developing alcoholic hepatitis.

The inflammation in alcoholic hepatitis can lead to symptoms such as jaundice (yellowing of the skin and eyes), abdominal pain, nausea, vomiting, loss of appetite, and fever. In severe cases, it can cause liver failure, which may be life-threatening. Treatment typically involves alcohol abstinence, supportive care, and medications to manage symptoms and prevent further liver damage. In some cases, hospitalization and more intensive treatments may be necessary.

A viral genome is the genetic material (DNA or RNA) that is present in a virus. It contains all the genetic information that a virus needs to replicate itself and infect its host. The size and complexity of viral genomes can vary greatly, ranging from a few thousand bases to hundreds of thousands of bases. Some viruses have linear genomes, while others have circular genomes. The genome of a virus also contains the information necessary for the virus to hijack the host cell's machinery and use it to produce new copies of the virus. Understanding the genetic makeup of viruses is important for developing vaccines and antiviral treatments.

Hepatitis Delta Antigens (HDAg) are proteins found on the surface of the Hepatitis Delta Virus (HDV), a defective virus that requires the assistance of the Hepatitis B Virus (HBV) to replicate. There are two types of HDAg: small (S-HDAg) and large (L-HDAg). S-HDAg is a 195-amino acid protein that is essential for viral replication, while L-HDAg is a 214-amino acid protein that regulates the packaging of the viral genome into new virus particles. The presence of HDAg can be used to diagnose HDV infection and distinguish it from other forms of hepatitis.

Seroepidemiologic studies are a type of epidemiological study that measures the presence and levels of antibodies in a population's blood serum to investigate the prevalence, distribution, and transmission of infectious diseases. These studies help to identify patterns of infection and immunity within a population, which can inform public health policies and interventions.

Seroepidemiologic studies typically involve collecting blood samples from a representative sample of individuals in a population and testing them for the presence of antibodies against specific pathogens. The results are then analyzed to estimate the prevalence of infection and immunity within the population, as well as any factors associated with increased or decreased risk of infection.

These studies can provide valuable insights into the spread of infectious diseases, including emerging and re-emerging infections, and help to monitor the effectiveness of vaccination programs. Additionally, seroepidemiologic studies can also be used to investigate the transmission dynamics of infectious agents, such as identifying sources of infection or tracking the spread of antibiotic resistance.

A blood donor is a person who voluntarily gives their own blood or blood components to be used for the benefit of another person in need. The blood donation process involves collecting the donor's blood, testing it for infectious diseases, and then storing it until it is needed by a patient. There are several types of blood donations, including:

1. Whole blood donation: This is the most common type of blood donation, where a donor gives one unit (about 450-500 milliliters) of whole blood. The blood is then separated into its components (red cells, plasma, and platelets) for transfusion to patients with different needs.
2. Double red cell donation: In this type of donation, the donor's blood is collected using a special machine that separates two units of red cells from the whole blood. The remaining plasma and platelets are returned to the donor during the donation process. This type of donation can be done every 112 days.
3. Platelet donation: A donor's blood is collected using a special machine that separates platelets from the whole blood. The red cells and plasma are then returned to the donor during the donation process. This type of donation can be done every seven days, up to 24 times a year.
4. Plasma donation: A donor's blood is collected using a special machine that separates plasma from the whole blood. The red cells and platelets are then returned to the donor during the donation process. This type of donation can be done every 28 days, up to 13 times a year.

Blood donors must meet certain eligibility criteria, such as being in good health, aged between 18 and 65 (in some countries, the upper age limit may vary), and weighing over 50 kg (110 lbs). Donors are also required to answer medical questionnaires and undergo a mini-physical examination before each donation. The frequency of blood donations varies depending on the type of donation and the donor's health status.

"Pan troglodytes" is the scientific name for a species of great apes known as the Common Chimpanzee. They are native to tropical rainforests in Western and Central Africa. Common Chimpanzees are our closest living relatives, sharing about 98.6% of our DNA. They are highly intelligent and social animals, capable of using tools, exhibiting complex behaviors, and displaying a range of emotions.

Here is a medical definition for 'Pan troglodytes':

The scientific name for the Common Chimpanzee species (genus Pan), a highly intelligent and social great ape native to tropical rainforests in Western and Central Africa. They are our closest living relatives, sharing approximately 98.6% of our DNA. Known for their complex behaviors, tool use, and emotional expression, Common Chimpanzees have been extensively studied in the fields of anthropology, psychology, and primatology to better understand human evolution and behavior.

Viral envelope proteins are structural proteins found in the envelope that surrounds many types of viruses. These proteins play a crucial role in the virus's life cycle, including attachment to host cells, fusion with the cell membrane, and entry into the host cell. They are typically made up of glycoproteins and are often responsible for eliciting an immune response in the host organism. The exact structure and function of viral envelope proteins vary between different types of viruses.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

Duck hepatitis B virus (DHBV) is not a medical definition related to human health, but it is a species of hepatitis B virus that primarily infects various species of ducks and other Anseriformes (waterfowl). It is closely related to the human hepatitis B virus (HBV), but it is not known to infect humans or other mammals.

DHBV, like HBV, is a DNA virus that targets the liver and can cause both acute and chronic infections. The virus is transmitted through the fecal-oral route and primarily affects young ducklings. Infection with DHBV can lead to liver damage and death in infected birds.

Researchers study DHBV as a model system for understanding HBV infection and pathogenesis, due to their similarities in viral structure, replication strategy, and host-virus interactions. However, it is important to note that DHBV is not a human health concern and does not pose a risk of infection to humans or other mammals.

HIV (Human Immunodeficiency Virus) infection is a viral illness that progressively attacks and weakens the immune system, making individuals more susceptible to other infections and diseases. The virus primarily infects CD4+ T cells, a type of white blood cell essential for fighting off infections. Over time, as the number of these immune cells declines, the body becomes increasingly vulnerable to opportunistic infections and cancers.

HIV infection has three stages:

1. Acute HIV infection: This is the initial stage that occurs within 2-4 weeks after exposure to the virus. During this period, individuals may experience flu-like symptoms such as fever, fatigue, rash, swollen glands, and muscle aches. The virus replicates rapidly, and the viral load in the body is very high.
2. Chronic HIV infection (Clinical latency): This stage follows the acute infection and can last several years if left untreated. Although individuals may not show any symptoms during this phase, the virus continues to replicate at low levels, and the immune system gradually weakens. The viral load remains relatively stable, but the number of CD4+ T cells declines over time.
3. AIDS (Acquired Immunodeficiency Syndrome): This is the most advanced stage of HIV infection, characterized by a severely damaged immune system and numerous opportunistic infections or cancers. At this stage, the CD4+ T cell count drops below 200 cells/mm3 of blood.

It's important to note that with proper antiretroviral therapy (ART), individuals with HIV infection can effectively manage the virus, maintain a healthy immune system, and significantly reduce the risk of transmission to others. Early diagnosis and treatment are crucial for improving long-term health outcomes and reducing the spread of HIV.

Prevalence, in medical terms, refers to the total number of people in a given population who have a particular disease or condition at a specific point in time, or over a specified period. It is typically expressed as a percentage or a ratio of the number of cases to the size of the population. Prevalence differs from incidence, which measures the number of new cases that develop during a certain period.

Liver function tests (LFTs) are a group of blood tests that are used to assess the functioning and health of the liver. These tests measure the levels of various enzymes, proteins, and waste products that are produced or metabolized by the liver. Some common LFTs include:

1. Alanine aminotransferase (ALT): An enzyme found primarily in the liver, ALT is released into the bloodstream in response to liver cell damage. Elevated levels of ALT may indicate liver injury or disease.
2. Aspartate aminotransferase (AST): Another enzyme found in various tissues, including the liver, heart, and muscles. Like ALT, AST is released into the bloodstream following tissue damage. High AST levels can be a sign of liver damage or other medical conditions.
3. Alkaline phosphatase (ALP): An enzyme found in several organs, including the liver, bile ducts, and bones. Elevated ALP levels may indicate a blockage in the bile ducts, liver disease, or bone disorders.
4. Gamma-glutamyl transferase (GGT): An enzyme found mainly in the liver, pancreas, and biliary system. Increased GGT levels can suggest liver disease, alcohol consumption, or the use of certain medications.
5. Bilirubin: A yellowish pigment produced when hemoglobin from red blood cells is broken down. Bilirubin is processed by the liver and excreted through bile. High bilirubin levels can indicate liver dysfunction, bile duct obstruction, or certain types of anemia.
6. Albumin: A protein produced by the liver that helps maintain fluid balance in the body and transports various substances in the blood. Low albumin levels may suggest liver damage, malnutrition, or kidney disease.
7. Total protein: A measure of all proteins present in the blood, including albumin and other types of proteins produced by the liver. Decreased total protein levels can indicate liver dysfunction or other medical conditions.

These tests are often ordered together as part of a routine health checkup or when evaluating symptoms related to liver function or disease. The results should be interpreted in conjunction with clinical findings, medical history, and other diagnostic tests.

I am not aware of any medical definition for the term "Egypt." Egypt is a country located in the northeastern corner of Africa, known for its rich history and cultural heritage. It is home to various ancient artifacts and monuments, including the Pyramids of Giza and the Sphinx.

If you have any specific medical or health-related questions related to Egypt, such as information about diseases prevalent in the country or healthcare practices there, I would be happy to try to help answer those for you.

Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.

Flaviviridae is a family of viruses that includes many important human pathogens. According to the International Committee on Taxonomy of Viruses (ICTV), Flaviviridae is divided into four genera: Flavivirus, Hepacivirus, Pegivirus, and Pestivirus. These viruses are enveloped and have a single-stranded, positive-sense RNA genome.

1. Flavivirus genus includes several medically important viruses, such as dengue virus, yellow fever virus, Japanese encephalitis virus, West Nile virus, Zika virus, and tick-borne encephalitis virus. These viruses are primarily transmitted by arthropod vectors (mosquitoes or ticks) and can cause a wide range of symptoms, from mild febrile illness to severe hemorrhagic fever and neuroinvasive disease.
2. Hepacivirus genus contains hepatitis C virus (HCV), which is a major causative agent of viral hepatitis and liver diseases, such as cirrhosis and hepatocellular carcinoma. HCV is primarily transmitted through percutaneous exposure to infected blood or blood products, sexual contact, and mother-to-child transmission during childbirth.
3. Pegivirus genus includes pegiviruses (formerly known as GB viruses) that are associated with persistent infection in humans and other animals. While pegiviruses can cause acute illness, they are mostly linked to asymptomatic or mild infections.
4. Pestivirus genus contains several animal pathogens, such as bovine viral diarrhea virus (BVDV), Classical swine fever virus (CSFV), and border disease virus (BDV). These viruses can cause significant economic losses in the livestock industry due to reproductive failure, growth retardation, and immunosuppression.

In summary, Flaviviridae is a family of enveloped, single-stranded, positive-sense RNA viruses that includes several important human and animal pathogens. The family is divided into four genera: Flavivirus, Hepacivirus, Pegivirus, and Pestivirus.

A biopsy is a medical procedure in which a small sample of tissue is taken from the body to be examined under a microscope for the presence of disease. This can help doctors diagnose and monitor various medical conditions, such as cancer, infections, or autoimmune disorders. The type of biopsy performed will depend on the location and nature of the suspected condition. Some common types of biopsies include:

1. Incisional biopsy: In this procedure, a surgeon removes a piece of tissue from an abnormal area using a scalpel or other surgical instrument. This type of biopsy is often used when the lesion is too large to be removed entirely during the initial biopsy.

2. Excisional biopsy: An excisional biopsy involves removing the entire abnormal area, along with a margin of healthy tissue surrounding it. This technique is typically employed for smaller lesions or when cancer is suspected.

3. Needle biopsy: A needle biopsy uses a thin, hollow needle to extract cells or fluid from the body. There are two main types of needle biopsies: fine-needle aspiration (FNA) and core needle biopsy. FNA extracts loose cells, while a core needle biopsy removes a small piece of tissue.

4. Punch biopsy: In a punch biopsy, a round, sharp tool is used to remove a small cylindrical sample of skin tissue. This type of biopsy is often used for evaluating rashes or other skin abnormalities.

5. Shave biopsy: During a shave biopsy, a thin slice of tissue is removed from the surface of the skin using a sharp razor-like instrument. This technique is typically used for superficial lesions or growths on the skin.

After the biopsy sample has been collected, it is sent to a laboratory where a pathologist will examine the tissue under a microscope and provide a diagnosis based on their findings. The results of the biopsy can help guide further treatment decisions and determine the best course of action for managing the patient's condition.

Hepatitis B virus (Woodchuck) refers to the hepadnavirus that naturally infects North American woodchucks (Marmota monax). This virus is closely related to the human Hepatitis B virus (HBV), and it is used as a model for studying HBV infection and related liver diseases in woodchucks. The woodchuck hepatitis virus (WHV) can cause both acute and chronic hepatitis, liver fibrosis, cirrhosis, and liver cancer in its natural host. The virus-host interactions and the disease progression in woodchucks closely mimic those observed in humans with HBV infection. Therefore, studies of WHV infection in woodchucks have contributed significantly to our understanding of HBV biology, host immune responses, and the development of novel therapies for HBV infection in humans.

Coinfection is a term used in medicine to describe a situation where a person is infected with more than one pathogen (infectious agent) at the same time. This can occur when a person is infected with two or more viruses, bacteria, parasites, or fungi. Coinfections can complicate the diagnosis and treatment of infectious diseases, as the symptoms of each infection can overlap and interact with each other.

Coinfections are common in certain populations, such as people who are immunocompromised, have chronic illnesses, or live in areas with high levels of infectious agents. For example, a person with HIV/AIDS may be more susceptible to coinfections with tuberculosis, hepatitis, or pneumocystis pneumonia. Similarly, a person who has recently undergone an organ transplant may be at risk for coinfections with cytomegalovirus, Epstein-Barr virus, or other opportunistic pathogens.

Coinfections can also occur in people who are otherwise healthy but are exposed to multiple infectious agents at once, such as through travel to areas with high levels of infectious diseases or through close contact with animals that carry infectious agents. For example, a person who travels to a tropical area may be at risk for coinfections with malaria and dengue fever, while a person who works on a farm may be at risk for coinfections with influenza and Q fever.

Effective treatment of coinfections requires accurate diagnosis and appropriate antimicrobial therapy for each pathogen involved. In some cases, treating one infection may help to resolve the other, but in other cases, both infections may need to be treated simultaneously to achieve a cure. Preventing coinfections is an important part of infectious disease control, and can be achieved through measures such as vaccination, use of personal protective equipment, and avoidance of high-risk behaviors.

Polymerase Chain Reaction (PCR) is a laboratory technique used to amplify specific regions of DNA. It enables the production of thousands to millions of copies of a particular DNA sequence in a rapid and efficient manner, making it an essential tool in various fields such as molecular biology, medical diagnostics, forensic science, and research.

The PCR process involves repeated cycles of heating and cooling to separate the DNA strands, allow primers (short sequences of single-stranded DNA) to attach to the target regions, and extend these primers using an enzyme called Taq polymerase, resulting in the exponential amplification of the desired DNA segment.

In a medical context, PCR is often used for detecting and quantifying specific pathogens (viruses, bacteria, fungi, or parasites) in clinical samples, identifying genetic mutations or polymorphisms associated with diseases, monitoring disease progression, and evaluating treatment effectiveness.

Medical Definition:

"Risk factors" are any attribute, characteristic or exposure of an individual that increases the likelihood of developing a disease or injury. They can be divided into modifiable and non-modifiable risk factors. Modifiable risk factors are those that can be changed through lifestyle choices or medical treatment, while non-modifiable risk factors are inherent traits such as age, gender, or genetic predisposition. Examples of modifiable risk factors include smoking, alcohol consumption, physical inactivity, and unhealthy diet, while non-modifiable risk factors include age, sex, and family history. It is important to note that having a risk factor does not guarantee that a person will develop the disease, but rather indicates an increased susceptibility.

Viremia is a medical term that refers to the presence of viruses in the bloodstream. It occurs when a virus successfully infects a host and replicates within the body's cells, releasing new viral particles into the blood. This condition can lead to various clinical manifestations depending on the specific virus involved and the immune response of the infected individual. Some viral infections result in asymptomatic viremia, while others can cause severe illness or even life-threatening conditions. The detection of viremia is crucial for diagnosing certain viral infections and monitoring disease progression or treatment effectiveness.

A cell line is a culture of cells that are grown in a laboratory for use in research. These cells are usually taken from a single cell or group of cells, and they are able to divide and grow continuously in the lab. Cell lines can come from many different sources, including animals, plants, and humans. They are often used in scientific research to study cellular processes, disease mechanisms, and to test new drugs or treatments. Some common types of human cell lines include HeLa cells (which come from a cancer patient named Henrietta Lacks), HEK293 cells (which come from embryonic kidney cells), and HUVEC cells (which come from umbilical vein endothelial cells). It is important to note that cell lines are not the same as primary cells, which are cells that are taken directly from a living organism and have not been grown in the lab.

Liver diseases refer to a wide range of conditions that affect the normal functioning of the liver. The liver is a vital organ responsible for various critical functions such as detoxification, protein synthesis, and production of biochemicals necessary for digestion.

Liver diseases can be categorized into acute and chronic forms. Acute liver disease comes on rapidly and can be caused by factors like viral infections (hepatitis A, B, C, D, E), drug-induced liver injury, or exposure to toxic substances. Chronic liver disease develops slowly over time, often due to long-term exposure to harmful agents or inherent disorders of the liver.

Common examples of liver diseases include hepatitis, cirrhosis (scarring of the liver tissue), fatty liver disease, alcoholic liver disease, autoimmune liver diseases, genetic/hereditary liver disorders (like Wilson's disease and hemochromatosis), and liver cancers. Symptoms may vary widely depending on the type and stage of the disease but could include jaundice, abdominal pain, fatigue, loss of appetite, nausea, and weight loss.

Early diagnosis and treatment are essential to prevent progression and potential complications associated with liver diseases.

An amino acid sequence is the specific order of amino acids in a protein or peptide molecule, formed by the linking of the amino group (-NH2) of one amino acid to the carboxyl group (-COOH) of another amino acid through a peptide bond. The sequence is determined by the genetic code and is unique to each type of protein or peptide. It plays a crucial role in determining the three-dimensional structure and function of proteins.

Tattooing is defined medically as the process of inserting pigment into the skin's dermis layer to change its color. This procedure creates a permanent design or image. The equipment used for tattooing includes an electrically powered tattoo machine, needles, and ink. Tattooing can carry potential risks such as infection, allergic reactions, and scarring. It is essential to ensure that all tattooing procedures are performed under sterile conditions and by a licensed professional to minimize these risks.

Liver failure is a serious condition in which the liver is no longer able to perform its normal functions, such as removing toxins and waste products from the blood, producing bile to help digest food, and regulating blood clotting. This can lead to a buildup of toxins in the body, jaundice (yellowing of the skin and eyes), fluid accumulation in the abdomen, and an increased risk of bleeding. Liver failure can be acute (sudden) or chronic (developing over time). Acute liver failure is often caused by medication toxicity, viral hepatitis, or other sudden illnesses. Chronic liver failure is most commonly caused by long-term damage from conditions such as cirrhosis, hepatitis, alcohol abuse, and non-alcoholic fatty liver disease.

It's important to note that Liver Failure is a life threatening condition and need immediate medical attention.

Drug resistance, viral, refers to the ability of a virus to continue replicating in the presence of antiviral drugs that are designed to inhibit or stop its growth. This occurs when the virus mutates and changes its genetic makeup in such a way that the drug can no longer effectively bind to and inhibit the function of its target protein, allowing the virus to continue infecting host cells and causing disease.

Viral drug resistance can develop due to several factors, including:

1. Mutations in the viral genome that alter the structure or function of the drug's target protein.
2. Changes in the expression levels or location of the drug's target protein within the virus-infected cell.
3. Activation of alternative pathways that allow the virus to replicate despite the presence of the drug.
4. Increased efflux of the drug from the virus-infected cell, reducing its intracellular concentration and effectiveness.

Viral drug resistance is a significant concern in the treatment of viral infections such as HIV, hepatitis B and C, herpes simplex virus, and influenza. It can lead to reduced treatment efficacy, increased risk of treatment failure, and the need for more toxic or expensive drugs. Therefore, it is essential to monitor viral drug resistance during treatment and adjust therapy accordingly to ensure optimal outcomes.

Lamivudine is an antiretroviral medication used in the treatment and management of HIV (Human Immunodeficiency Virus) infection and HBV (Hepatitis B Virus) infection. It is a nucleoside reverse transcriptase inhibitor (NRTI), which means it works by blocking the action of the reverse transcriptase enzyme that the viruses need to multiply. By doing this, Lamivudine helps to reduce the amount of the virus in the body, which in turn helps to slow down or prevent the damage that the virus can cause to the immune system and improve the patient's quality of life.

The medical definition of Lamivudine is: "A synthetic nucleoside analogue with activity against both HIV-1 and HBV. It is used in the treatment of HIV infection and AIDS, as well as chronic hepatitis B."

Recurrence, in a medical context, refers to the return of symptoms or signs of a disease after a period of improvement or remission. It indicates that the condition has not been fully eradicated and may require further treatment. Recurrence is often used to describe situations where a disease such as cancer comes back after initial treatment, but it can also apply to other medical conditions. The likelihood of recurrence varies depending on the type of disease and individual patient factors.

Aspartate aminotransferases (ASTs) are a group of enzymes found in various tissues throughout the body, including the heart, liver, and muscles. They play a crucial role in the metabolic process of transferring amino groups between different molecules.

In medical terms, AST is often used as a blood test to measure the level of this enzyme in the serum. Elevated levels of AST can indicate damage or injury to tissues that contain this enzyme, such as the liver or heart. For example, liver disease, including hepatitis and cirrhosis, can cause elevated AST levels due to damage to liver cells. Similarly, heart attacks can also result in increased AST levels due to damage to heart muscle tissue.

It is important to note that an AST test alone cannot diagnose a specific medical condition, but it can provide valuable information when used in conjunction with other diagnostic tests and clinical evaluation.

A blood transfusion is a medical procedure in which blood or its components are transferred from one individual (donor) to another (recipient) through a vein. The donated blood can be fresh whole blood, packed red blood cells, platelets, plasma, or cryoprecipitate, depending on the recipient's needs. Blood transfusions are performed to replace lost blood due to severe bleeding, treat anemia, support patients undergoing major surgeries, or manage various medical conditions such as hemophilia, thalassemia, and leukemia. The donated blood must be carefully cross-matched with the recipient's blood type to minimize the risk of transfusion reactions.

Untranslated regions (UTRs) are sections of an mRNA molecule that do not contain information for protein synthesis. There are two types of UTRs: 5' UTR, which is located at the 5' end of the mRNA molecule, and 3' UTR, which is located at the 3' end.

The 5' UTR typically contains regulatory elements that control the translation of the mRNA into protein. These elements can affect the efficiency and timing of translation, as well as the stability of the mRNA molecule. The 5' UTR may also contain upstream open reading frames (uORFs), which are short sequences that can be translated into small peptides and potentially regulate the translation of the main coding sequence.

The length and sequence composition of the 5' UTR can have significant impacts on gene expression, and variations in these regions have been associated with various diseases, including cancer and neurological disorders. Therefore, understanding the structure and function of 5' UTRs is an important area of research in molecular biology and genetics.

Chronic Hepatitis D is a liver infection caused by the hepatitis delta virus (HDV). It is often considered a serious form of hepatitis because it can lead to more severe liver disease than hepatitis B alone. HDV is a defective virus that requires the presence of hepatitis B surface antigen (HBsAg) to replicate and cause infection. Therefore, chronic hepatitis D only occurs in individuals who have an underlying chronic hepatitis B infection.

Chronic hepatitis D is characterized by persistent inflammation and damage to the liver, which can lead to scarring (fibrosis), cirrhosis, liver failure, and increased risk of liver cancer over time. Symptoms may include fatigue, joint pain, loss of appetite, nausea, vomiting, abdominal pain, dark urine, and jaundice. However, some people with chronic hepatitis D may not have any symptoms until the disease has progressed to a more advanced stage.

Chronic hepatitis D is diagnosed through blood tests that detect HDV antibodies and antigens, as well as liver function tests and imaging studies to assess liver damage. Treatment typically involves antiviral therapy to suppress the replication of both HBV and HDV, as well as supportive care to manage symptoms and prevent complications. In some cases, a liver transplant may be necessary for individuals with advanced liver disease due to chronic hepatitis D.

An acute disease is a medical condition that has a rapid onset, develops quickly, and tends to be short in duration. Acute diseases can range from minor illnesses such as a common cold or flu, to more severe conditions such as pneumonia, meningitis, or a heart attack. These types of diseases often have clear symptoms that are easy to identify, and they may require immediate medical attention or treatment.

Acute diseases are typically caused by an external agent or factor, such as a bacterial or viral infection, a toxin, or an injury. They can also be the result of a sudden worsening of an existing chronic condition. In general, acute diseases are distinct from chronic diseases, which are long-term medical conditions that develop slowly over time and may require ongoing management and treatment.

Examples of acute diseases include:

* Acute bronchitis: a sudden inflammation of the airways in the lungs, often caused by a viral infection.
* Appendicitis: an inflammation of the appendix that can cause severe pain and requires surgical removal.
* Gastroenteritis: an inflammation of the stomach and intestines, often caused by a viral or bacterial infection.
* Migraine headaches: intense headaches that can last for hours or days, and are often accompanied by nausea, vomiting, and sensitivity to light and sound.
* Myocardial infarction (heart attack): a sudden blockage of blood flow to the heart muscle, often caused by a buildup of plaque in the coronary arteries.
* Pneumonia: an infection of the lungs that can cause coughing, chest pain, and difficulty breathing.
* Sinusitis: an inflammation of the sinuses, often caused by a viral or bacterial infection.

It's important to note that while some acute diseases may resolve on their own with rest and supportive care, others may require medical intervention or treatment to prevent complications and promote recovery. If you are experiencing symptoms of an acute disease, it is always best to seek medical attention to ensure proper diagnosis and treatment.

Retrospective studies, also known as retrospective research or looking back studies, are a type of observational study that examines data from the past to draw conclusions about possible causal relationships between risk factors and outcomes. In these studies, researchers analyze existing records, medical charts, or previously collected data to test a hypothesis or answer a specific research question.

Retrospective studies can be useful for generating hypotheses and identifying trends, but they have limitations compared to prospective studies, which follow participants forward in time from exposure to outcome. Retrospective studies are subject to biases such as recall bias, selection bias, and information bias, which can affect the validity of the results. Therefore, retrospective studies should be interpreted with caution and used primarily to generate hypotheses for further testing in prospective studies.

RNA-dependent RNA polymerase, also known as RNA replicase, is an enzyme that catalyzes the production of RNA from an RNA template. It plays a crucial role in the replication of certain viruses, such as positive-strand RNA viruses and retroviruses, which use RNA as their genetic material. The enzyme uses the existing RNA strand as a template to create a new complementary RNA strand, effectively replicating the viral genome. This process is essential for the propagation of these viruses within host cells and is a target for antiviral therapies.

A carrier state is a condition in which a person carries and may be able to transmit a genetic disorder or infectious disease, but does not show any symptoms of the disease themselves. This occurs when an individual has a recessive allele for a genetic disorder or is infected with a pathogen, but does not have the necessary combination of genes or other factors required to develop the full-blown disease.

For example, in the case of cystic fibrosis, which is caused by mutations in the CFTR gene, a person who carries one normal allele and one mutated allele for the disease is considered a carrier. They do not have symptoms of cystic fibrosis themselves, but they can pass the mutated allele on to their offspring, who may then develop the disease if they inherit the mutation from both parents.

Similarly, in the case of infectious diseases, a person who is infected with a pathogen but does not show any symptoms may still be able to transmit the infection to others. This is known as being an asymptomatic carrier or a healthy carrier. For example, some people who are infected with hepatitis B virus (HBV) may not develop any symptoms of liver disease, but they can still transmit the virus to others through contact with their blood or other bodily fluids.

It's important to note that in some cases, carriers of certain genetic disorders or infectious diseases may have mild or atypical symptoms that do not meet the full criteria for a diagnosis of the disease. In these cases, they may be considered to have a "reduced penetrance" or "incomplete expression" of the disorder or infection.

A chronic disease is a long-term medical condition that often progresses slowly over a period of years and requires ongoing management and care. These diseases are typically not fully curable, but symptoms can be managed to improve quality of life. Common chronic diseases include heart disease, stroke, cancer, diabetes, arthritis, and COPD (chronic obstructive pulmonary disease). They are often associated with advanced age, although they can also affect children and younger adults. Chronic diseases can have significant impacts on individuals' physical, emotional, and social well-being, as well as on healthcare systems and society at large.

Virus internalization, also known as viral entry, is the process by which a virus enters a host cell to infect it and replicate its genetic material. This process typically involves several steps:

1. Attachment: The viral envelope proteins bind to specific receptors on the surface of the host cell.
2. Entry: The virus then enters the host cell through endocytosis or membrane fusion, depending on the type of virus.
3. Uncoating: Once inside the host cell, the viral capsid is removed, releasing the viral genome into the cytoplasm.
4. Replication: The viral genome then uses the host cell's machinery to replicate itself and produce new viral particles.

It's important to note that the specific mechanisms of virus internalization can vary widely between different types of viruses, and are an active area of research in virology and infectious disease.

"Marmota" is a genus of large ground squirrels that are native to North America and Eurasia. These animals, also known as woodchucks or whistle pigs, are well-known for their ability to hibernate during the winter months. They typically live in burrows that they dig themselves, and their diet consists mainly of grasses, leaves, and shrubs. Marmotas are social creatures and often live in colonies with a dominant male and several females. While "Marmota" is a valid term in medical literature, it is more commonly found in the fields of biology and zoology rather than medicine.

In the field of medicine, "time factors" refer to the duration of symptoms or time elapsed since the onset of a medical condition, which can have significant implications for diagnosis and treatment. Understanding time factors is crucial in determining the progression of a disease, evaluating the effectiveness of treatments, and making critical decisions regarding patient care.

For example, in stroke management, "time is brain," meaning that rapid intervention within a specific time frame (usually within 4.5 hours) is essential to administering tissue plasminogen activator (tPA), a clot-busting drug that can minimize brain damage and improve patient outcomes. Similarly, in trauma care, the "golden hour" concept emphasizes the importance of providing definitive care within the first 60 minutes after injury to increase survival rates and reduce morbidity.

Time factors also play a role in monitoring the progression of chronic conditions like diabetes or heart disease, where regular follow-ups and assessments help determine appropriate treatment adjustments and prevent complications. In infectious diseases, time factors are crucial for initiating antibiotic therapy and identifying potential outbreaks to control their spread.

Overall, "time factors" encompass the significance of recognizing and acting promptly in various medical scenarios to optimize patient outcomes and provide effective care.

Phylogeny is the evolutionary history and relationship among biological entities, such as species or genes, based on their shared characteristics. In other words, it refers to the branching pattern of evolution that shows how various organisms have descended from a common ancestor over time. Phylogenetic analysis involves constructing a tree-like diagram called a phylogenetic tree, which depicts the inferred evolutionary relationships among organisms or genes based on molecular sequence data or other types of characters. This information is crucial for understanding the diversity and distribution of life on Earth, as well as for studying the emergence and spread of diseases.

Disease progression is the worsening or advancement of a medical condition over time. It refers to the natural course of a disease, including its development, the severity of symptoms and complications, and the impact on the patient's overall health and quality of life. Understanding disease progression is important for developing appropriate treatment plans, monitoring response to therapy, and predicting outcomes.

The rate of disease progression can vary widely depending on the type of medical condition, individual patient factors, and the effectiveness of treatment. Some diseases may progress rapidly over a short period of time, while others may progress more slowly over many years. In some cases, disease progression may be slowed or even halted with appropriate medical interventions, while in other cases, the progression may be inevitable and irreversible.

In clinical practice, healthcare providers closely monitor disease progression through regular assessments, imaging studies, and laboratory tests. This information is used to guide treatment decisions and adjust care plans as needed to optimize patient outcomes and improve quality of life.

Viral proteins are the proteins that are encoded by the viral genome and are essential for the viral life cycle. These proteins can be structural or non-structural and play various roles in the virus's replication, infection, and assembly process. Structural proteins make up the physical structure of the virus, including the capsid (the protein shell that surrounds the viral genome) and any envelope proteins (that may be present on enveloped viruses). Non-structural proteins are involved in the replication of the viral genome and modulation of the host cell environment to favor viral replication. Overall, a thorough understanding of viral proteins is crucial for developing antiviral therapies and vaccines.

An Enzyme-Linked Immunosorbent Assay (ELISA) is a type of analytical biochemistry assay used to detect and quantify the presence of a substance, typically a protein or peptide, in a liquid sample. It takes its name from the enzyme-linked antibodies used in the assay.

In an ELISA, the sample is added to a well containing a surface that has been treated to capture the target substance. If the target substance is present in the sample, it will bind to the surface. Next, an enzyme-linked antibody specific to the target substance is added. This antibody will bind to the captured target substance if it is present. After washing away any unbound material, a substrate for the enzyme is added. If the enzyme is present due to its linkage to the antibody, it will catalyze a reaction that produces a detectable signal, such as a color change or fluorescence. The intensity of this signal is proportional to the amount of target substance present in the sample, allowing for quantification.

ELISAs are widely used in research and clinical settings to detect and measure various substances, including hormones, viruses, and bacteria. They offer high sensitivity, specificity, and reproducibility, making them a reliable choice for many applications.

A mutation is a permanent change in the DNA sequence of an organism's genome. Mutations can occur spontaneously or be caused by environmental factors such as exposure to radiation, chemicals, or viruses. They may have various effects on the organism, ranging from benign to harmful, depending on where they occur and whether they alter the function of essential proteins. In some cases, mutations can increase an individual's susceptibility to certain diseases or disorders, while in others, they may confer a survival advantage. Mutations are the driving force behind evolution, as they introduce new genetic variability into populations, which can then be acted upon by natural selection.

A cohort study is a type of observational study in which a group of individuals who share a common characteristic or exposure are followed up over time to determine the incidence of a specific outcome or outcomes. The cohort, or group, is defined based on the exposure status (e.g., exposed vs. unexposed) and then monitored prospectively to assess for the development of new health events or conditions.

Cohort studies can be either prospective or retrospective in design. In a prospective cohort study, participants are enrolled and followed forward in time from the beginning of the study. In contrast, in a retrospective cohort study, researchers identify a cohort that has already been assembled through medical records, insurance claims, or other sources and then look back in time to assess exposure status and health outcomes.

Cohort studies are useful for establishing causality between an exposure and an outcome because they allow researchers to observe the temporal relationship between the two. They can also provide information on the incidence of a disease or condition in different populations, which can be used to inform public health policy and interventions. However, cohort studies can be expensive and time-consuming to conduct, and they may be subject to bias if participants are not representative of the population or if there is loss to follow-up.

Gene expression regulation, viral, refers to the processes that control the production of viral gene products, such as proteins and nucleic acids, during the viral life cycle. This can involve both viral and host cell factors that regulate transcription, RNA processing, translation, and post-translational modifications of viral genes.

Viral gene expression regulation is critical for the virus to replicate and produce progeny virions. Different types of viruses have evolved diverse mechanisms to regulate their gene expression, including the use of promoters, enhancers, transcription factors, RNA silencing, and epigenetic modifications. Understanding these regulatory processes can provide insights into viral pathogenesis and help in the development of antiviral therapies.

Prospective studies, also known as longitudinal studies, are a type of cohort study in which data is collected forward in time, following a group of individuals who share a common characteristic or exposure over a period of time. The researchers clearly define the study population and exposure of interest at the beginning of the study and follow up with the participants to determine the outcomes that develop over time. This type of study design allows for the investigation of causal relationships between exposures and outcomes, as well as the identification of risk factors and the estimation of disease incidence rates. Prospective studies are particularly useful in epidemiology and medical research when studying diseases with long latency periods or rare outcomes.

Antibodies, viral are proteins produced by the immune system in response to an infection with a virus. These antibodies are capable of recognizing and binding to specific antigens on the surface of the virus, which helps to neutralize or destroy the virus and prevent its replication. Once produced, these antibodies can provide immunity against future infections with the same virus.

Viral antibodies are typically composed of four polypeptide chains - two heavy chains and two light chains - that are held together by disulfide bonds. The binding site for the antigen is located at the tip of the Y-shaped structure, formed by the variable regions of the heavy and light chains.

There are five classes of antibodies in humans: IgA, IgD, IgE, IgG, and IgM. Each class has a different function and is distributed differently throughout the body. For example, IgG is the most common type of antibody found in the bloodstream and provides long-term immunity against viruses, while IgA is found primarily in mucous membranes and helps to protect against respiratory and gastrointestinal infections.

In addition to their role in the immune response, viral antibodies can also be used as diagnostic tools to detect the presence of a specific virus in a patient's blood or other bodily fluids.

Sexually Transmitted Diseases (STDs) are infections that can be passed from one person to another through sexual contact. When focusing on viral STDs, these are infections caused by viruses that can be spread through sexual contact including vaginal, anal, and oral sex. Some common examples of viral STDs include HIV/AIDS, genital herpes, human papillomavirus (HPV), hepatitis B, and genital warts. These viral infections can lead to serious health complications if not diagnosed and treated promptly. It's important to note that some viral STDs may not have noticeable symptoms, but can still be passed on to sexual partners and cause long-term health problems.

Blood-borne pathogens are microorganisms that are present in human blood and can cause disease. They include viruses such as HIV, Hepatitis B and C, and other bacteria and parasites. These pathogens can be transmitted through contact with infected blood or other bodily fluids, primarily through needlesticks or other sharps-related injuries, mucous membrane exposure, or skin exposure with open wounds or cuts. It's important for healthcare workers and others who may come into contact with blood or bodily fluids to be aware of the risks and take appropriate precautions to prevent exposure and transmission.

Interleukins (ILs) are a group of naturally occurring proteins that are important in the immune system. They are produced by various cells, including immune cells like lymphocytes and macrophages, and they help regulate the immune response by facilitating communication between different types of cells. Interleukins can have both pro-inflammatory and anti-inflammatory effects, depending on the specific interleukin and the context in which it is produced. They play a role in various biological processes, including the development of immune responses, inflammation, and hematopoiesis (the formation of blood cells).

There are many different interleukins that have been identified, and they are numbered according to the order in which they were discovered. For example, IL-1, IL-2, IL-3, etc. Each interleukin has a specific set of functions and targets certain types of cells. Dysregulation of interleukins has been implicated in various diseases, including autoimmune disorders, infections, and cancer.

Jaundice is a medical condition characterized by the yellowing of the skin, sclera (whites of the eyes), and mucous membranes due to an excess of bilirubin in the bloodstream. Bilirubin is a yellow-orange pigment produced when hemoglobin from red blood cells is broken down. Normally, bilirubin is processed by the liver and excreted through bile into the digestive system. However, if there's an issue with bilirubin metabolism or elimination, it can accumulate in the body, leading to jaundice.

Jaundice can be a symptom of various underlying conditions, such as liver diseases (hepatitis, cirrhosis), gallbladder issues (gallstones, tumors), or blood disorders (hemolysis). It is essential to consult a healthcare professional if jaundice is observed, as it may indicate a severe health problem requiring prompt medical attention.

Hemodialysis units in a hospital setting are specialized departments or facilities that provide hemodialysis treatment to patients with kidney failure. Hemodialysis is a process of purifying the blood of waste products and excess fluids using a machine (hemodialysis machine) and a semi-permeable membrane (dialyzer). The procedure typically involves accessing the patient's bloodstream through a surgically created vascular access, such as a fistula or graft, and passing the blood through the dialyzer to remove waste products and excess fluids.

Hospital hemodialysis units are staffed by trained healthcare professionals, including nephrologists (kidney specialists), nurses, technicians, and support personnel. These units provide inpatient and outpatient services for patients who require hemodialysis due to acute or chronic kidney failure, as well as those who need dialysis while hospitalized for other medical conditions.

Hospital hemodialysis units may offer various types of hemodialysis treatments, including conventional hemodialysis, high-flux hemodialysis, hemofiltration, and hemodiafiltration. They also provide education and support to patients and their families regarding dialysis treatment options, lifestyle modifications, and long-term management of kidney disease.

Hemophilia A is a genetic bleeding disorder caused by a deficiency in clotting factor VIII. This results in impaired blood clotting and prolonged bleeding, particularly after injuries or surgeries. Symptoms can range from mild to severe, with the most severe form resulting in spontaneous bleeding into joints and muscles, leading to pain, swelling, and potential joint damage over time. Hemophilia A primarily affects males, as it is an X-linked recessive disorder, and is usually inherited from a carrier mother. However, about one third of cases result from a spontaneous mutation in the gene for factor VIII. Treatment typically involves replacement therapy with infusions of factor VIII concentrates to prevent or control bleeding episodes.

RNA helicases are a class of enzymes that are capable of unwinding RNA secondary structures using the energy derived from ATP hydrolysis. They play crucial roles in various cellular processes involving RNA, such as transcription, splicing, translation, ribosome biogenesis, and RNA degradation. RNA helicases can be divided into several superfamilies based on their sequence and structural similarities, with the two largest being superfamily 1 (SF1) and superfamily 2 (SF2). These enzymes typically contain conserved motifs that are involved in ATP binding and hydrolysis, as well as RNA binding. By unwinding RNA structures, RNA helicases facilitate the access of other proteins to their target RNAs, thereby enabling the coordinated regulation of RNA metabolism.

Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) is a laboratory technique used in molecular biology to amplify and detect specific DNA sequences. This technique is particularly useful for the detection and quantification of RNA viruses, as well as for the analysis of gene expression.

The process involves two main steps: reverse transcription and polymerase chain reaction (PCR). In the first step, reverse transcriptase enzyme is used to convert RNA into complementary DNA (cDNA) by reading the template provided by the RNA molecule. This cDNA then serves as a template for the PCR amplification step.

In the second step, the PCR reaction uses two primers that flank the target DNA sequence and a thermostable polymerase enzyme to repeatedly copy the targeted cDNA sequence. The reaction mixture is heated and cooled in cycles, allowing the primers to anneal to the template, and the polymerase to extend the new strand. This results in exponential amplification of the target DNA sequence, making it possible to detect even small amounts of RNA or cDNA.

RT-PCR is a sensitive and specific technique that has many applications in medical research and diagnostics, including the detection of viruses such as HIV, hepatitis C virus, and SARS-CoV-2 (the virus that causes COVID-19). It can also be used to study gene expression, identify genetic mutations, and diagnose genetic disorders.

Drug-Induced Liver Injury (DILI) is a medical term that refers to liver damage or injury caused by the use of medications or drugs. This condition can vary in severity, from mild abnormalities in liver function tests to severe liver failure, which may require a liver transplant.

The exact mechanism of DILI can differ depending on the drug involved, but it generally occurs when the liver metabolizes the drug into toxic compounds that damage liver cells. This can happen through various pathways, including direct toxicity to liver cells, immune-mediated reactions, or metabolic idiosyncrasies.

Symptoms of DILI may include jaundice (yellowing of the skin and eyes), fatigue, abdominal pain, nausea, vomiting, loss of appetite, and dark urine. In severe cases, it can lead to complications such as ascites, encephalopathy, and bleeding disorders.

The diagnosis of DILI is often challenging because it requires the exclusion of other potential causes of liver injury. Liver function tests, imaging studies, and sometimes liver biopsies may be necessary to confirm the diagnosis. Treatment typically involves discontinuing the offending drug and providing supportive care until the liver recovers. In some cases, medications that protect the liver or promote its healing may be used.

A polyprotein is a long, continuous chain of amino acids that are produced through the translation of a single mRNA (messenger RNA) molecule. This occurs in some viruses, including retroviruses like HIV, where the viral genome contains instructions for the production of one or more polyproteins.

After the polyprotein is synthesized, it is cleaved into smaller, functional proteins by virus-encoded proteases. These individual proteins then assemble to form new virus particles. The concept of polyproteins is important in understanding viral replication and may provide targets for antiviral therapy.

DNA Sequence Analysis is the systematic determination of the order of nucleotides in a DNA molecule. It is a critical component of modern molecular biology, genetics, and genetic engineering. The process involves determining the exact order of the four nucleotide bases - adenine (A), guanine (G), cytosine (C), and thymine (T) - in a DNA molecule or fragment. This information is used in various applications such as identifying gene mutations, studying evolutionary relationships, developing molecular markers for breeding, and diagnosing genetic diseases.

The process of DNA Sequence Analysis typically involves several steps, including DNA extraction, PCR amplification (if necessary), purification, sequencing reaction, and electrophoresis. The resulting data is then analyzed using specialized software to determine the exact sequence of nucleotides.

In recent years, high-throughput DNA sequencing technologies have revolutionized the field of genomics, enabling the rapid and cost-effective sequencing of entire genomes. This has led to an explosion of genomic data and new insights into the genetic basis of many diseases and traits.

Genetic variation refers to the differences in DNA sequences among individuals and populations. These variations can result from mutations, genetic recombination, or gene flow between populations. Genetic variation is essential for evolution by providing the raw material upon which natural selection acts. It can occur within a single gene, between different genes, or at larger scales, such as differences in the number of chromosomes or entire sets of chromosomes. The study of genetic variation is crucial in understanding the genetic basis of diseases and traits, as well as the evolutionary history and relationships among species.

A virion is the complete, infectious form of a virus outside its host cell. It consists of the viral genome (DNA or RNA) enclosed within a protein coat called the capsid, which is often surrounded by a lipid membrane called the envelope. The envelope may contain viral proteins and glycoproteins that aid in attachment to and entry into host cells during infection. The term "virion" emphasizes the infectious nature of the virus particle, as opposed to non-infectious components like individual capsid proteins or naked viral genome.

Fatty liver, also known as hepatic steatosis, is a medical condition characterized by the abnormal accumulation of fat in the liver. The liver's primary function is to process nutrients, filter blood, and fight infections, among other tasks. When excess fat builds up in the liver cells, it can impair liver function and lead to inflammation, scarring, and even liver failure if left untreated.

Fatty liver can be caused by various factors, including alcohol consumption, obesity, nonalcoholic fatty liver disease (NAFLD), viral hepatitis, and certain medications or medical conditions. NAFLD is the most common cause of fatty liver in the United States and other developed countries, affecting up to 25% of the population.

Symptoms of fatty liver may include fatigue, weakness, weight loss, loss of appetite, nausea, abdominal pain or discomfort, and jaundice (yellowing of the skin and eyes). However, many people with fatty liver do not experience any symptoms, making it essential to diagnose and manage the condition through regular check-ups and blood tests.

Treatment for fatty liver depends on the underlying cause. Lifestyle changes such as weight loss, exercise, and dietary modifications are often recommended for people with NAFLD or alcohol-related fatty liver disease. Medications may also be prescribed to manage related conditions such as diabetes, high cholesterol, or metabolic syndrome. In severe cases of liver damage, a liver transplant may be necessary.

Spontaneous remission in a medical context refers to the disappearance or significant improvement of symptoms of a disease or condition without any specific treatment being administered. In other words, it's a situation where the disease resolves on its own, without any apparent cause. While spontaneous remission can occur in various conditions, it is relatively rare and not well understood. It's important to note that just because a remission occurs without treatment doesn't mean that medical care should be avoided, as many conditions can worsen or lead to complications if left untreated.

A biological marker, often referred to as a biomarker, is a measurable indicator that reflects the presence or severity of a disease state, or a response to a therapeutic intervention. Biomarkers can be found in various materials such as blood, tissues, or bodily fluids, and they can take many forms, including molecular, histologic, radiographic, or physiological measurements.

In the context of medical research and clinical practice, biomarkers are used for a variety of purposes, such as:

1. Diagnosis: Biomarkers can help diagnose a disease by indicating the presence or absence of a particular condition. For example, prostate-specific antigen (PSA) is a biomarker used to detect prostate cancer.
2. Monitoring: Biomarkers can be used to monitor the progression or regression of a disease over time. For instance, hemoglobin A1c (HbA1c) levels are monitored in diabetes patients to assess long-term blood glucose control.
3. Predicting: Biomarkers can help predict the likelihood of developing a particular disease or the risk of a negative outcome. For example, the presence of certain genetic mutations can indicate an increased risk for breast cancer.
4. Response to treatment: Biomarkers can be used to evaluate the effectiveness of a specific treatment by measuring changes in the biomarker levels before and after the intervention. This is particularly useful in personalized medicine, where treatments are tailored to individual patients based on their unique biomarker profiles.

It's important to note that for a biomarker to be considered clinically valid and useful, it must undergo rigorous validation through well-designed studies, including demonstrating sensitivity, specificity, reproducibility, and clinical relevance.

"Saguinus" is a genus of small, New World monkeys that are commonly known as tamarins. They are native to the forests of Central and South America. Tamarins have a slender body with long limbs, a specialized claw-like nail on their second digit of the foot, and a distinct coat coloration that varies between species. They primarily feed on fruits, insects, and exudates from trees. Tamarins are also known for their social structure, typically living in family groups consisting of a mated pair and their offspring.

Sensitivity and specificity are statistical measures used to describe the performance of a diagnostic test or screening tool in identifying true positive and true negative results.

* Sensitivity refers to the proportion of people who have a particular condition (true positives) who are correctly identified by the test. It is also known as the "true positive rate" or "recall." A highly sensitive test will identify most or all of the people with the condition, but may also produce more false positives.
* Specificity refers to the proportion of people who do not have a particular condition (true negatives) who are correctly identified by the test. It is also known as the "true negative rate." A highly specific test will identify most or all of the people without the condition, but may also produce more false negatives.

In medical testing, both sensitivity and specificity are important considerations when evaluating a diagnostic test. High sensitivity is desirable for screening tests that aim to identify as many cases of a condition as possible, while high specificity is desirable for confirmatory tests that aim to rule out the condition in people who do not have it.

It's worth noting that sensitivity and specificity are often influenced by factors such as the prevalence of the condition in the population being tested, the threshold used to define a positive result, and the reliability and validity of the test itself. Therefore, it's important to consider these factors when interpreting the results of a diagnostic test.

I apologize for any confusion, but "prisoners" is not a medical term. It generally refers to individuals who are deprived of their personal freedom and are being held in a prison or jail as a result of being convicted of a crime or while awaiting trial. If you have any questions related to medical terminology, I would be happy to help!

A cell line that is derived from tumor cells and has been adapted to grow in culture. These cell lines are often used in research to study the characteristics of cancer cells, including their growth patterns, genetic changes, and responses to various treatments. They can be established from many different types of tumors, such as carcinomas, sarcomas, and leukemias. Once established, these cell lines can be grown and maintained indefinitely in the laboratory, allowing researchers to conduct experiments and studies that would not be feasible using primary tumor cells. It is important to note that tumor cell lines may not always accurately represent the behavior of the original tumor, as they can undergo genetic changes during their time in culture.

Cryoglobulins are immunoglobulins (a type of antibody) that precipitate or become insoluble at reduced temperatures, typically below 37°C (98.6°F), and re-dissolve when rewarmed. They can be found in various clinical conditions such as infections, inflammatory diseases, and lymphoproliferative disorders.

The presence of cryoglobulins in the blood can lead to a variety of symptoms, including purpura (a type of skin rash), arthralgias (joint pain), neuropathy (nerve damage), and glomerulonephritis (kidney inflammation). The diagnosis of cryoglobulinemia is made by detecting the presence of cryoglobulins in the serum, which requires special handling and processing of the blood sample. Treatment of cryoglobulinemia depends on the underlying cause and may include medications such as corticosteroids, immunosuppressive agents, or targeted therapies.

Flaviviridae infections refer to a group of diseases caused by viruses that belong to the Flaviviridae family. This family includes several important human pathogens, such as dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, and Zika virus.

These viruses are primarily transmitted to humans through the bites of infected mosquitoes or ticks. The symptoms of Flaviviridae infections can vary depending on the specific virus, but they often include fever, headache, muscle and joint pain, rash, and fatigue. In severe cases, these infections can lead to serious complications such as hemorrhagic fever, encephalitis, or neuropathy.

Prevention measures for Flaviviridae infections include avoiding mosquito and tick bites, using insect repellent, wearing protective clothing, and getting vaccinated if vaccines are available for the specific virus. Treatment is generally supportive and may include fluid replacement, pain relief, and management of complications. There are no specific antiviral treatments available for most Flaviviridae infections.

I believe there may be a slight misunderstanding in your question. "Prisons" are not a medical term, but rather a term used to describe facilities where individuals who have been convicted of crimes serve their sentences of incarceration. They are run by correctional systems and law enforcement agencies, not healthcare providers or medical organizations.

However, I can certainly provide information about the potential impact of prisons on health and healthcare. Prisons can have significant effects on the physical and mental health of inmates due to factors such as overcrowding, violence, limited access to healthcare services, and the transmission of infectious diseases like HIV and hepatitis C. Additionally, many inmates have underlying health issues that may be exacerbated by incarceration, including substance use disorders, mental illness, and chronic medical conditions.

Therefore, it is important for correctional facilities to provide adequate healthcare services to their inmates, not only to meet basic human rights standards but also to promote public health more broadly by reducing the spread of infectious diseases and improving the health outcomes of individuals who will eventually be released back into the community.

I apologize, but "Brazil" is not a medical term or condition. It is the largest country in both South America and Latin America by land area and population. If you have any questions related to medical terminology or health concerns, please provide more information and I will do my best to help.

GB virus B (GBV-B) is not a widely accepted or used term in the medical community. It was initially identified as a possible new virus in the 1960s, during an investigation into hepatitis outbreaks among laboratory workers handling chimpanzee serum and feces. However, further research could not confirm its existence as a separate virus.

The name "GB virus B" comes from the initials of the person (G. Barker) who provided the original serum sample where the virus was first detected, and "B" to differentiate it from another related virus called GB virus A (GBV-A).

Currently, GBV-B is not considered a distinct human pathogen or a significant cause of any known diseases. It is not included in the list of human viruses by the International Committee on Taxonomy of Viruses (ICTV) and is not recognized as a medical condition by major health organizations such as the World Health Organization (WHO) or the Centers for Disease Control and Prevention (CDC).

Follow-up studies are a type of longitudinal research that involve repeated observations or measurements of the same variables over a period of time, in order to understand their long-term effects or outcomes. In medical context, follow-up studies are often used to evaluate the safety and efficacy of medical treatments, interventions, or procedures.

In a typical follow-up study, a group of individuals (called a cohort) who have received a particular treatment or intervention are identified and then followed over time through periodic assessments or data collection. The data collected may include information on clinical outcomes, adverse events, changes in symptoms or functional status, and other relevant measures.

The results of follow-up studies can provide important insights into the long-term benefits and risks of medical interventions, as well as help to identify factors that may influence treatment effectiveness or patient outcomes. However, it is important to note that follow-up studies can be subject to various biases and limitations, such as loss to follow-up, recall bias, and changes in clinical practice over time, which must be carefully considered when interpreting the results.

Host-pathogen interactions refer to the complex and dynamic relationship between a living organism (the host) and a disease-causing agent (the pathogen). This interaction can involve various molecular, cellular, and physiological processes that occur between the two entities. The outcome of this interaction can determine whether the host will develop an infection or not, as well as the severity and duration of the illness.

During host-pathogen interactions, the pathogen may release virulence factors that allow it to evade the host's immune system, colonize tissues, and obtain nutrients for its survival and replication. The host, in turn, may mount an immune response to recognize and eliminate the pathogen, which can involve various mechanisms such as inflammation, phagocytosis, and the production of antimicrobial agents.

Understanding the intricacies of host-pathogen interactions is crucial for developing effective strategies to prevent and treat infectious diseases. This knowledge can help identify new targets for therapeutic interventions, inform vaccine design, and guide public health policies to control the spread of infectious agents.

In epidemiology, the incidence of a disease is defined as the number of new cases of that disease within a specific population over a certain period of time. It is typically expressed as a rate, with the number of new cases in the numerator and the size of the population at risk in the denominator. Incidence provides information about the risk of developing a disease during a given time period and can be used to compare disease rates between different populations or to monitor trends in disease occurrence over time.

Serologic tests are laboratory tests that detect the presence or absence of antibodies or antigens in a patient's serum (the clear liquid that separates from clotted blood). These tests are commonly used to diagnose infectious diseases, as well as autoimmune disorders and other medical conditions.

In serologic testing for infectious diseases, a sample of the patient's blood is collected and allowed to clot. The serum is then separated from the clot and tested for the presence of antibodies that the body has produced in response to an infection. The test may be used to identify the specific type of infection or to determine whether the infection is active or has resolved.

Serologic tests can also be used to diagnose autoimmune disorders, such as rheumatoid arthritis and lupus, by detecting the presence of antibodies that are directed against the body's own tissues. These tests can help doctors confirm a diagnosis and monitor the progression of the disease.

It is important to note that serologic tests are not always 100% accurate and may produce false positive or false negative results. Therefore, they should be interpreted in conjunction with other clinical findings and laboratory test results.

Needle sharing is the reuse of needles or syringes by more than one person, often in the context of injecting drugs. This behavior is considered high-risk as it can lead to the transmission of bloodborne pathogens such as HIV, Hepatitis B, and Hepatitis C. It's a significant public health concern due to its association with intravenous drug use.

A case-control study is an observational research design used to identify risk factors or causes of a disease or health outcome. In this type of study, individuals with the disease or condition (cases) are compared with similar individuals who do not have the disease or condition (controls). The exposure history or other characteristics of interest are then compared between the two groups to determine if there is an association between the exposure and the disease.

Case-control studies are often used when it is not feasible or ethical to conduct a randomized controlled trial, as they can provide valuable insights into potential causes of diseases or health outcomes in a relatively short period of time and at a lower cost than other study designs. However, because case-control studies rely on retrospective data collection, they are subject to biases such as recall bias and selection bias, which can affect the validity of the results. Therefore, it is important to carefully design and conduct case-control studies to minimize these potential sources of bias.

A Severity of Illness Index is a measurement tool used in healthcare to assess the severity of a patient's condition and the risk of mortality or other adverse outcomes. These indices typically take into account various physiological and clinical variables, such as vital signs, laboratory values, and co-morbidities, to generate a score that reflects the patient's overall illness severity.

Examples of Severity of Illness Indices include the Acute Physiology and Chronic Health Evaluation (APACHE) system, the Simplified Acute Physiology Score (SAPS), and the Mortality Probability Model (MPM). These indices are often used in critical care settings to guide clinical decision-making, inform prognosis, and compare outcomes across different patient populations.

It is important to note that while these indices can provide valuable information about a patient's condition, they should not be used as the sole basis for clinical decision-making. Rather, they should be considered in conjunction with other factors, such as the patient's overall clinical presentation, treatment preferences, and goals of care.

DNA primers are short single-stranded DNA molecules that serve as a starting point for DNA synthesis. They are typically used in laboratory techniques such as the polymerase chain reaction (PCR) and DNA sequencing. The primer binds to a complementary sequence on the DNA template through base pairing, providing a free 3'-hydroxyl group for the DNA polymerase enzyme to add nucleotides and synthesize a new strand of DNA. This allows for specific and targeted amplification or analysis of a particular region of interest within a larger DNA molecule.

Organophosphonates are a class of organic compounds characterized by the presence of a carbon-phosphorus bond. They contain a phosphonic acid group, which consists of a phosphorus atom bonded to four oxygen or nitrogen atoms, with one of those bonds being replaced by a carbon atom.

In a medical context, organophosphonates are commonly used as radiopharmaceuticals in diagnostic nuclear medicine procedures, such as bone scans. These compounds have the ability to bind to hydroxyapatite, the mineral component of bones, and can be labeled with radioactive isotopes for imaging purposes. They may also be used in therapeutic settings, including as treatments for conditions such as tumor-induced hypercalcemia and Paget's disease of bone.

It is important to note that organophosphonates are distinct from organophosphates, another class of compounds that contain a phosphorus atom bonded to three oxygen or sulfur atoms and one carbon atom. Organophosphates have been widely used as pesticides and chemical warfare agents, and can pose significant health risks due to their toxicity.

GB virus C (GBV-C), also known as hepatitis G virus (HGV) or human pegivirus (HPgV), is a single-stranded, positive-sense RNA virus that belongs to the Flaviviridae family. It was initially identified in 1995 and is closely related to hepatitis C virus (HCV). However, unlike HCV, GBV-C is not associated with any significant liver disease and does not cause hepatitis.

GBV-C infection is usually asymptomatic and often resolves on its own without treatment. It is primarily transmitted through blood and bodily fluids, such as through sharing needles or during sexual contact. Vertical transmission from mother to child can also occur, although it is less common than with HCV.

While GBV-C infection is generally benign, there is some evidence to suggest that it may have immunomodulatory effects and could potentially impact the course of other viral infections, such as HIV. However, more research is needed to fully understand the clinical significance of GBV-C infection.

Virology is the study of viruses, their classification, and their effects on living organisms. It involves the examination of viral genetic material, viral replication, how viruses cause disease, and the development of antiviral drugs and vaccines to treat or prevent virus infections. Virologists study various types of viruses that can infect animals, plants, and microorganisms, as well as understand their evolution and transmission patterns.

An antigen is any substance that can stimulate an immune response, particularly the production of antibodies. Viral antigens are antigens that are found on or produced by viruses. They can be proteins, glycoproteins, or carbohydrates present on the surface or inside the viral particle.

Viral antigens play a crucial role in the immune system's recognition and response to viral infections. When a virus infects a host cell, it may display its antigens on the surface of the infected cell. This allows the immune system to recognize and target the infected cells for destruction, thereby limiting the spread of the virus.

Viral antigens are also important targets for vaccines. Vaccines typically work by introducing a harmless form of a viral antigen to the body, which then stimulates the production of antibodies and memory T-cells that can recognize and respond quickly and effectively to future infections with the actual virus.

It's worth noting that different types of viruses have different antigens, and these antigens can vary between strains of the same virus. This is why there are often different vaccines available for different viral diseases, and why flu vaccines need to be updated every year to account for changes in the circulating influenza virus strains.

Protease inhibitors are a class of antiviral drugs that are used to treat infections caused by retroviruses, such as the human immunodeficiency virus (HIV), which is responsible for causing AIDS. These drugs work by blocking the activity of protease enzymes, which are necessary for the replication and multiplication of the virus within infected cells.

Protease enzymes play a crucial role in the life cycle of retroviruses by cleaving viral polyproteins into functional units that are required for the assembly of new viral particles. By inhibiting the activity of these enzymes, protease inhibitors prevent the virus from replicating and spreading to other cells, thereby slowing down the progression of the infection.

Protease inhibitors are often used in combination with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART) for the treatment of HIV/AIDS. Common examples of protease inhibitors include saquinavir, ritonavir, indinavir, and atazanavir. While these drugs have been successful in improving the outcomes of people living with HIV/AIDS, they can also cause side effects such as nausea, diarrhea, headaches, and lipodystrophy (changes in body fat distribution).

Infectious pregnancy complications refer to infections that occur during pregnancy and can affect the mother, fetus, or both. These infections can lead to serious consequences such as preterm labor, low birth weight, birth defects, stillbirth, or even death. Some common infectious agents that can cause pregnancy complications include:

1. Bacteria: Examples include group B streptococcus, Escherichia coli, and Listeria monocytogenes, which can cause sepsis, meningitis, or pneumonia in the mother and lead to preterm labor or stillbirth.
2. Viruses: Examples include cytomegalovirus, rubella, varicella-zoster, and HIV, which can cause congenital anomalies, developmental delays, or transmission of the virus to the fetus.
3. Parasites: Examples include Toxoplasma gondii, which can cause severe neurological damage in the fetus if transmitted during pregnancy.
4. Fungi: Examples include Candida albicans, which can cause fungal infections in the mother and lead to preterm labor or stillbirth.

Preventive measures such as vaccination, good hygiene practices, and avoiding high-risk behaviors can help reduce the risk of infectious pregnancy complications. Prompt diagnosis and treatment of infections during pregnancy are also crucial to prevent adverse outcomes.

Vaccination is a simple, safe, and effective way to protect people against harmful diseases, before they come into contact with them. It uses your body's natural defenses to build protection to specific infections and makes your immune system stronger.

A vaccination usually contains a small, harmless piece of a virus or bacteria (or toxins produced by these germs) that has been made inactive or weakened so it won't cause the disease itself. This piece of the germ is known as an antigen. When the vaccine is introduced into the body, the immune system recognizes the antigen as foreign and produces antibodies to fight it.

If a person then comes into contact with the actual disease-causing germ, their immune system will recognize it and immediately produce antibodies to destroy it. The person is therefore protected against that disease. This is known as active immunity.

Vaccinations are important for both individual and public health. They prevent the spread of contagious diseases and protect vulnerable members of the population, such as young children, the elderly, and people with weakened immune systems who cannot be vaccinated or for whom vaccination is not effective.

Renal dialysis is a medical procedure that is used to artificially remove waste products, toxins, and excess fluids from the blood when the kidneys are no longer able to perform these functions effectively. This process is also known as hemodialysis.

During renal dialysis, the patient's blood is circulated through a special machine called a dialyzer or an artificial kidney, which contains a semi-permeable membrane that filters out waste products and excess fluids from the blood. The cleaned blood is then returned to the patient's body.

Renal dialysis is typically recommended for patients with advanced kidney disease or kidney failure, such as those with end-stage renal disease (ESRD). It is a life-sustaining treatment that helps to maintain the balance of fluids and electrolytes in the body, prevent the buildup of waste products and toxins, and control blood pressure.

There are two main types of renal dialysis: hemodialysis and peritoneal dialysis. Hemodialysis is the most common type and involves using a dialyzer to filter the blood outside the body. Peritoneal dialysis, on the other hand, involves placing a catheter in the abdomen and using the lining of the abdomen (peritoneum) as a natural filter to remove waste products and excess fluids from the body.

Overall, renal dialysis is an essential treatment option for patients with kidney failure, helping them to maintain their quality of life and prolong their survival.

Vertical transmission of infectious diseases refers to the spread of an infection from an infected mother to her offspring during pregnancy, childbirth, or breastfeeding. This mode of transmission can occur through several pathways:

1. Transplacental transmission: The infection crosses the placenta and reaches the fetus while it is still in the womb. Examples include HIV, syphilis, and toxoplasmosis.
2. Intrauterine infection: The mother's infection causes direct damage to the developing fetus or its surrounding tissues, leading to complications such as congenital defects. Examples include rubella and cytomegalovirus (CMV).
3. Perinatal transmission: This occurs during childbirth when the infant comes into contact with the mother's infected genital tract or bodily fluids. Examples include group B streptococcus, herpes simplex virus (HSV), and hepatitis B.
4. Postnatal transmission: This occurs after birth, often through breastfeeding, when the infant ingests infected milk or comes into contact with the mother's contaminated bodily fluids. Examples include HIV and HTLV-I (human T-lymphotropic virus type I).

Vertical transmission is a significant concern in public health, as it can lead to severe complications, congenital disabilities, or even death in newborns. Preventive measures, such as prenatal screening, vaccination, and antimicrobial treatment, are crucial for reducing the risk of vertical transmission and ensuring better outcomes for both mothers and their offspring.

I'm sorry for any confusion, but "Pakistan" is a country in South Asia and not a medical term or condition. If you have any medical questions or terms you would like defined, I would be happy to help!

Virus assembly, also known as virion assembly, is the final stage in the virus life cycle where individual viral components come together to form a complete viral particle or virion. This process typically involves the self-assembly of viral capsid proteins around the viral genome (DNA or RNA) and, in enveloped viruses, the acquisition of a lipid bilayer membrane containing viral glycoproteins. The specific mechanisms and regulation of virus assembly vary among different viral families, but it is often directed by interactions between viral structural proteins and genomic nucleic acid.

Transaminases, also known as aminotransferases, are a group of enzymes found in various tissues of the body, particularly in the liver, heart, muscle, and kidneys. They play a crucial role in the metabolism of amino acids, the building blocks of proteins.

There are two major types of transaminases: aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Both enzymes are normally present in low concentrations in the bloodstream. However, when tissues that contain these enzymes are damaged or injured, such as during liver disease or muscle damage, the levels of AST and ALT in the blood may significantly increase.

Measurement of serum transaminase levels is a common laboratory test used to assess liver function and detect liver injury or damage. Increased levels of these enzymes in the blood can indicate conditions such as hepatitis, liver cirrhosis, drug-induced liver injury, heart attack, and muscle disorders. It's important to note that while elevated transaminase levels may suggest liver disease, they do not specify the type or cause of the condition, and further diagnostic tests are often required for accurate diagnosis and treatment.

"Ducks" is not a medical term. It is a common name used to refer to a group of birds that belong to the family Anatidae, which also includes swans and geese. Some ducks are hunted for their meat, feathers, or down, but they do not have any specific medical relevance. If you have any questions about a specific medical term or concept, I would be happy to help if you could provide more information!

A cross-sectional study is a type of observational research design that examines the relationship between variables at one point in time. It provides a snapshot or a "cross-section" of the population at a particular moment, allowing researchers to estimate the prevalence of a disease or condition and identify potential risk factors or associations.

In a cross-sectional study, data is collected from a sample of participants at a single time point, and the variables of interest are measured simultaneously. This design can be used to investigate the association between exposure and outcome, but it cannot establish causality because it does not follow changes over time.

Cross-sectional studies can be conducted using various data collection methods, such as surveys, interviews, or medical examinations. They are often used in epidemiology to estimate the prevalence of a disease or condition in a population and to identify potential risk factors that may contribute to its development. However, because cross-sectional studies only provide a snapshot of the population at one point in time, they cannot account for changes over time or determine whether exposure preceded the outcome.

Therefore, while cross-sectional studies can be useful for generating hypotheses and identifying potential associations between variables, further research using other study designs, such as cohort or case-control studies, is necessary to establish causality and confirm any findings.

Reagent kits, diagnostic are prepackaged sets of chemical reagents and other components designed for performing specific diagnostic tests or assays. These kits are often used in clinical laboratories to detect and measure the presence or absence of various biomarkers, such as proteins, antibodies, antigens, nucleic acids, or small molecules, in biological samples like blood, urine, or tissues.

Diagnostic reagent kits typically contain detailed instructions for their use, along with the necessary reagents, controls, and sometimes specialized equipment or supplies. They are designed to simplify the testing process, reduce human error, and increase standardization, ensuring accurate and reliable results. Examples of diagnostic reagent kits include those used for pregnancy tests, infectious disease screening, drug testing, genetic testing, and cancer biomarker detection.

Mononuclear leukocytes are a type of white blood cells (leukocytes) that have a single, large nucleus. They include lymphocytes (B-cells, T-cells, and natural killer cells), monocytes, and dendritic cells. These cells play important roles in the body's immune system, including defending against infection and disease, and participating in immune responses and surveillance. Mononuclear leukocytes can be found in the bloodstream as well as in tissues throughout the body. They are involved in both innate and adaptive immunity, providing specific and nonspecific defense mechanisms to protect the body from harmful pathogens and other threats.

Viral genes refer to the genetic material present in viruses that contains the information necessary for their replication and the production of viral proteins. In DNA viruses, the genetic material is composed of double-stranded or single-stranded DNA, while in RNA viruses, it is composed of single-stranded or double-stranded RNA.

Viral genes can be classified into three categories: early, late, and structural. Early genes encode proteins involved in the replication of the viral genome, modulation of host cell processes, and regulation of viral gene expression. Late genes encode structural proteins that make up the viral capsid or envelope. Some viruses also have structural genes that are expressed throughout their replication cycle.

Understanding the genetic makeup of viruses is crucial for developing antiviral therapies and vaccines. By targeting specific viral genes, researchers can develop drugs that inhibit viral replication and reduce the severity of viral infections. Additionally, knowledge of viral gene sequences can inform the development of vaccines that stimulate an immune response to specific viral proteins.

HIV (Human Immunodeficiency Virus) is a species of lentivirus (a subgroup of retrovirus) that causes HIV infection and over time, HIV infection can lead to AIDS (Acquired Immunodeficiency Syndrome). This virus attacks the immune system, specifically the CD4 cells, also known as T cells, which are a type of white blood cell that helps coordinate the body's immune response. As HIV destroys these cells, the body becomes more vulnerable to other infections and diseases. It is primarily spread through bodily fluids like blood, semen, vaginal fluids, and breast milk.

It's important to note that while there is no cure for HIV, with proper medical care, HIV can be controlled. Treatment for HIV is called antiretroviral therapy (ART). If taken as prescribed, this medicine reduces the amount of HIV in the body to a very low level, which keeps the immune system working and prevents illness. This treatment also greatly reduces the risk of transmission.

An epitope is a specific region on the surface of an antigen (a molecule that can trigger an immune response) that is recognized by an antibody, B-cell receptor, or T-cell receptor. It is also commonly referred to as an antigenic determinant. Epitopes are typically composed of linear amino acid sequences or conformational structures made up of discontinuous amino acids in the antigen. They play a crucial role in the immune system's ability to differentiate between self and non-self molecules, leading to the targeted destruction of foreign substances like viruses and bacteria. Understanding epitopes is essential for developing vaccines, diagnostic tests, and immunotherapies.

Body piercing is a form of body modification where a hole is made in the skin to insert an ornament, jewelry, or decorative item. It can be performed on various parts of the body such as ears, nose, lips, eyebrows, tongue, navel, and other areas. The process typically involves using a needle to puncture the skin and create an opening for the jewelry to pass through.

There are several types of body piercings, including:

1. Ear piercing - the most common type of body piercing, where a hole is made in the ear lobe or cartilage to insert earrings.
2. Navel piercing - a piercing that passes through the skin around the navel or belly button.
3. Lip piercing - a piercing that passes through the lip or the skin surrounding the lips, such as the labret or Monroe piercing.
4. Nose piercing - a piercing that passes through the nostril or septum of the nose.
5. Tongue piercing - a piercing that passes through the tongue.
6. Eyebrow piercing - a piercing that passes through the skin above or below the eyebrow.

Body piercings can pose risks such as infection, bleeding, scarring, and allergic reactions to jewelry materials. It is essential to practice proper hygiene and aftercare procedures to minimize these risks. Additionally, it is recommended to consult a professional piercer who follows safety guidelines and uses sterile equipment.

I am not aware of a specific medical definition for the term "China." Generally, it is used to refer to:

1. The People's Republic of China (PRC), which is a country in East Asia. It is the most populous country in the world and the fourth largest by geographical area. Its capital city is Beijing.
2. In a historical context, "China" was used to refer to various dynasties and empires that existed in East Asia over thousands of years. The term "Middle Kingdom" or "Zhongguo" (中国) has been used by the Chinese people to refer to their country for centuries.
3. In a more general sense, "China" can also be used to describe products or goods that originate from or are associated with the People's Republic of China.

If you have a specific context in which you encountered the term "China" related to medicine, please provide it so I can give a more accurate response.

"Tupaia" is not a term found in general medical terminology. It is most likely referring to a genus of small mammals known as tree shrews, also called "tupaias." They are native to Southeast Asia and are not closely related to shrews, but rather belong to their own order, Scandentia.

However, if you're referring to a specific medical condition or concept that uses the term "Tupaia," I would need more context to provide an accurate definition.

Transfection is a term used in molecular biology that refers to the process of deliberately introducing foreign genetic material (DNA, RNA or artificial gene constructs) into cells. This is typically done using chemical or physical methods, such as lipofection or electroporation. Transfection is widely used in research and medical settings for various purposes, including studying gene function, producing proteins, developing gene therapies, and creating genetically modified organisms. It's important to note that transfection is different from transduction, which is the process of introducing genetic material into cells using viruses as vectors.

Amantadine is an antiviral medication that is primarily used to prevent and treat certain types of influenza (flu). It works by stopping the virus from multiplying in your body. In addition to its antiviral properties, amantadine also has central nervous system (CNS) stimulant and dopaminergic effects, which make it useful in the treatment of Parkinson's disease and various movement disorders.

The medical definition of Amantadine is:

A synthetic symmetrical tricyclic amine used as an antiviral agent to treat and prevent influenza A infection and as an anti-parkinsonian drug to control extrapyramidal symptoms caused by neuroleptic agents. The antiviral effect may be due to interference with viral uncoating or replication. The anti-parkinsonian effect may be due to a combination of dopamine agonist and NMDA receptor antagonist properties. (Stedman's Medical Dictionary, 28th edition)

Please note that the use of Amantadine for various medical conditions should always be under the supervision of a healthcare professional, as they will consider potential benefits and risks and provide appropriate guidance.

Viral structural proteins are the protein components that make up the viral particle or capsid, providing structure and stability to the virus. These proteins are encoded by the viral genome and are involved in the assembly of new virus particles during the replication cycle. They can be classified into different types based on their location and function, such as capsid proteins, matrix proteins, and envelope proteins. Capsid proteins form the protein shell that encapsulates the viral genome, while matrix proteins are located between the capsid and the envelope, and envelope proteins are embedded in the lipid bilayer membrane that surrounds some viruses.

Adenine is a purine nucleotide base that is a fundamental component of DNA and RNA, the genetic material of living organisms. In DNA, adenine pairs with thymine via double hydrogen bonds, while in RNA, it pairs with uracil. Adenine is essential for the structure and function of nucleic acids, as well as for energy transfer reactions in cells through its role in the formation of adenosine triphosphate (ATP), the primary energy currency of the cell.

Alcoholic Liver Cirrhosis is a medical condition characterized by irreversible scarring (fibrosis) and damage to the liver caused by excessive consumption of alcohol over an extended period. The liver's normal structure and function are progressively impaired as healthy liver tissue is replaced by scarred tissue, leading to the formation of nodules (regenerative noduli).

The condition typically develops after years of heavy drinking, with a higher risk for those who consume more than 60 grams of pure alcohol daily. The damage caused by alcoholic liver cirrhosis can be life-threatening and may result in complications such as:

1. Ascites (accumulation of fluid in the abdomen)
2. Encephalopathy (neurological dysfunction due to liver failure)
3. Esophageal varices (dilated veins in the esophagus that can rupture and bleed)
4. Hepatorenal syndrome (kidney failure caused by liver disease)
5. Increased susceptibility to infections
6. Liver cancer (hepatocellular carcinoma)
7. Portal hypertension (increased blood pressure in the portal vein that supplies blood to the liver)

Abstaining from alcohol and managing underlying medical conditions are crucial for slowing down or halting disease progression. Treatment may involve medications, dietary changes, and supportive care to address complications. In severe cases, a liver transplant might be necessary.

Infectious disease transmission refers to the spread of an infectious agent or pathogen from an infected person, animal, or contaminated object to another susceptible host. This can occur through various routes, including:

1. Contact transmission: Direct contact with an infected person or animal, such as through touching, kissing, or sexual contact.
2. Droplet transmission: Inhalation of respiratory droplets containing the pathogen, which are generated when an infected person coughs, sneezes, talks, or breathes heavily.
3. Airborne transmission: Inhalation of smaller particles called aerosols that can remain suspended in the air for longer periods and travel farther distances than droplets.
4. Fecal-oral transmission: Consuming food or water contaminated with fecal matter containing the pathogen, often through poor hygiene practices.
5. Vector-borne transmission: Transmission via an intermediate vector, such as a mosquito or tick, that becomes infected after feeding on an infected host and then transmits the pathogen to another host during a subsequent blood meal.
6. Vehicle-borne transmission: Consuming food or water contaminated with the pathogen through vehicles like soil, water, or fomites (inanimate objects).

Preventing infectious disease transmission is crucial in controlling outbreaks and epidemics. Measures include good personal hygiene, vaccination, use of personal protective equipment (PPE), safe food handling practices, and environmental disinfection.

A "drug user" is a person who uses or consumes illegal drugs, such as heroin, cocaine, or methamphetamine, or misuses prescription medications for recreational purposes or to self-medicate. It's important to note that the term "drug user" can have stigmatizing connotations and may not accurately reflect the complexity of an individual's relationship with drugs. Many prefer terms like "person who uses drugs" or "substance user," which emphasize the personhood and agency of the individual rather than reducing them to their drug use.

It's also worth noting that there is a wide range of drug use behaviors, from occasional recreational use to heavy, dependent use. The medical community recognizes that problematic drug use can lead to negative health consequences, but it's important to approach individuals who use drugs with compassion and understanding rather than judgment. Providing access to evidence-based treatments and harm reduction services can help reduce the risks associated with drug use and support individuals in making positive changes in their lives.

Immunoenzyme techniques are a group of laboratory methods used in immunology and clinical chemistry that combine the specificity of antibody-antigen reactions with the sensitivity and amplification capabilities of enzyme reactions. These techniques are primarily used for the detection, quantitation, or identification of various analytes (such as proteins, hormones, drugs, viruses, or bacteria) in biological samples.

In immunoenzyme techniques, an enzyme is linked to an antibody or antigen, creating a conjugate. This conjugate then interacts with the target analyte in the sample, forming an immune complex. The presence and amount of this immune complex can be visualized or measured by detecting the enzymatic activity associated with it.

There are several types of immunoenzyme techniques, including:

1. Enzyme-linked Immunosorbent Assay (ELISA): A widely used method for detecting and quantifying various analytes in a sample. In ELISA, an enzyme is attached to either the capture antibody or the detection antibody. After the immune complex formation, a substrate is added that reacts with the enzyme, producing a colored product that can be measured spectrophotometrically.
2. Immunoblotting (Western blot): A method used for detecting specific proteins in a complex mixture, such as a protein extract from cells or tissues. In this technique, proteins are separated by gel electrophoresis and transferred to a membrane, where they are probed with an enzyme-conjugated antibody directed against the target protein.
3. Immunohistochemistry (IHC): A method used for detecting specific antigens in tissue sections or cells. In IHC, an enzyme-conjugated primary or secondary antibody is applied to the sample, and the presence of the antigen is visualized using a chromogenic substrate that produces a colored product at the site of the antigen-antibody interaction.
4. Immunofluorescence (IF): A method used for detecting specific antigens in cells or tissues by employing fluorophore-conjugated antibodies. The presence of the antigen is visualized using a fluorescence microscope.
5. Enzyme-linked immunosorbent assay (ELISA): A method used for detecting and quantifying specific antigens or antibodies in liquid samples, such as serum or culture supernatants. In ELISA, an enzyme-conjugated detection antibody is added after the immune complex formation, and a substrate is added that reacts with the enzyme to produce a colored product that can be measured spectrophotometrically.

These techniques are widely used in research and diagnostic laboratories for various applications, including protein characterization, disease diagnosis, and monitoring treatment responses.

Bilirubin is a yellowish pigment that is produced by the liver when it breaks down old red blood cells. It is a normal byproduct of hemoglobin metabolism and is usually conjugated (made water-soluble) in the liver before being excreted through the bile into the digestive system. Elevated levels of bilirubin can cause jaundice, a yellowing of the skin and eyes. Increased bilirubin levels may indicate liver disease or other medical conditions such as gallstones or hemolysis. It is also measured to assess liver function and to help diagnose various liver disorders.

Protein biosynthesis is the process by which cells generate new proteins. It involves two major steps: transcription and translation. Transcription is the process of creating a complementary RNA copy of a sequence of DNA. This RNA copy, or messenger RNA (mRNA), carries the genetic information to the site of protein synthesis, the ribosome. During translation, the mRNA is read by transfer RNA (tRNA) molecules, which bring specific amino acids to the ribosome based on the sequence of nucleotides in the mRNA. The ribosome then links these amino acids together in the correct order to form a polypeptide chain, which may then fold into a functional protein. Protein biosynthesis is essential for the growth and maintenance of all living organisms.

An amino acid substitution is a type of mutation in which one amino acid in a protein is replaced by another. This occurs when there is a change in the DNA sequence that codes for a particular amino acid in a protein. The genetic code is redundant, meaning that most amino acids are encoded by more than one codon (a sequence of three nucleotides). As a result, a single base pair change in the DNA sequence may not necessarily lead to an amino acid substitution. However, if a change does occur, it can have a variety of effects on the protein's structure and function, depending on the nature of the substituted amino acids. Some substitutions may be harmless, while others may alter the protein's activity or stability, leading to disease.

Hepadnaviridae is a family of small, enveloped viruses that primarily infect the liver cells (hepatocytes) of various species, including humans. The name "Hepadnaviridae" is derived from "hepa" for hepatotrophic (liver-tropic) and "DNA" for the DNA genome of the viruses.

The most well-known member of this family is the human hepatitis B virus (HBV), which causes acute and chronic liver infections, leading to various clinical manifestations such as hepatitis, cirrhosis, and hepatocellular carcinoma.

Hepadnaviruses have a unique replication strategy that involves reverse transcription of an RNA intermediate, making them distinct from other DNA viruses. Their genome is partially double-stranded, with the minus strand being complete and the plus strand incomplete or absent. The genome encodes for four overlapping open reading frames (ORFs) that give rise to several viral proteins, including the surface antigen (HBsAg), core protein (HBcAg), polymerase, and X protein (HBx).

The family Hepadnaviridae includes several other members that infect animals, such as woodchuck hepatitis virus (WHV), ground squirrel hepatitis virus (GSHV), and duck hepatitis B virus (DHBV). These viruses serve as valuable models for understanding the biology and pathogenesis of HBV in humans.

Nucleic acid conformation refers to the three-dimensional structure that nucleic acids (DNA and RNA) adopt as a result of the bonding patterns between the atoms within the molecule. The primary structure of nucleic acids is determined by the sequence of nucleotides, while the conformation is influenced by factors such as the sugar-phosphate backbone, base stacking, and hydrogen bonding.

Two common conformations of DNA are the B-form and the A-form. The B-form is a right-handed helix with a diameter of about 20 Å and a pitch of 34 Å, while the A-form has a smaller diameter (about 18 Å) and a shorter pitch (about 25 Å). RNA typically adopts an A-form conformation.

The conformation of nucleic acids can have significant implications for their function, as it can affect their ability to interact with other molecules such as proteins or drugs. Understanding the conformational properties of nucleic acids is therefore an important area of research in molecular biology and medicine.

Needlestick injuries are sharp object injuries typically involving hollow-bore needles, which can result in exposure to bloodborne pathogens. They often occur during the use or disposal of contaminated needles in healthcare settings. These injuries pose a significant risk for transmission of infectious diseases such as HIV, Hepatitis B, and Hepatitis C. It is essential to follow strict protocols for handling and disposing of needles and other sharp objects to minimize the risk of needlestick injuries.

Protein binding, in the context of medical and biological sciences, refers to the interaction between a protein and another molecule (known as the ligand) that results in a stable complex. This process is often reversible and can be influenced by various factors such as pH, temperature, and concentration of the involved molecules.

In clinical chemistry, protein binding is particularly important when it comes to drugs, as many of them bind to proteins (especially albumin) in the bloodstream. The degree of protein binding can affect a drug's distribution, metabolism, and excretion, which in turn influence its therapeutic effectiveness and potential side effects.

Protein-bound drugs may be less available for interaction with their target tissues, as only the unbound or "free" fraction of the drug is active. Therefore, understanding protein binding can help optimize dosing regimens and minimize adverse reactions.

I'm sorry for any confusion, but "United States" is a geopolitical entity, specifically the name of the country consisting of 50 states, and it is not a medical term or concept. Therefore, I can't provide a medical definition for it. If you have any questions related to health, medicine, or biology, I would be happy to try to help answer those!

Immunosuppressive agents are medications that decrease the activity of the immune system. They are often used to prevent the rejection of transplanted organs and to treat autoimmune diseases, where the immune system mistakenly attacks the body's own tissues. These drugs work by interfering with the immune system's normal responses, which helps to reduce inflammation and damage to tissues. However, because they suppress the immune system, people who take immunosuppressive agents are at increased risk for infections and other complications. Examples of immunosuppressive agents include corticosteroids, azathioprine, cyclophosphamide, mycophenolate mofetil, tacrolimus, and sirolimus.

Duck hepatitis virus (DHV) is not typically included in the medical definition of "hepatitis viruses" as it primarily affects birds, particularly ducks and geese, rather than humans. However, for the sake of completeness:

Duck hepatitis virus (DHV) is a species of small, single-stranded RNA viruses that belong to the family Picornaviridae. There are three serotypes of DHV (1, 2, and 3), which can cause an acute, often fatal, disease in young ducklings known as duck viral hepatitis.

DHV-1 and DHV-3 primarily affect ducklings under 4 weeks of age, causing liver damage, hemorrhage, and neurological symptoms. DHV-2, on the other hand, is associated with a milder disease in ducks but can cause a more severe illness in geese.

It's important to note that DHV is not related to human hepatitis viruses (A, B, C, D, and E) and does not pose a risk to human health.

Immunoglobulin G (IgG) is a type of antibody, which is a protective protein produced by the immune system in response to foreign substances like bacteria or viruses. IgG is the most abundant type of antibody in human blood, making up about 75-80% of all antibodies. It is found in all body fluids and plays a crucial role in fighting infections caused by bacteria, viruses, and toxins.

IgG has several important functions:

1. Neutralization: IgG can bind to the surface of bacteria or viruses, preventing them from attaching to and infecting human cells.
2. Opsonization: IgG coats the surface of pathogens, making them more recognizable and easier for immune cells like neutrophils and macrophages to phagocytose (engulf and destroy) them.
3. Complement activation: IgG can activate the complement system, a group of proteins that work together to help eliminate pathogens from the body. Activation of the complement system leads to the formation of the membrane attack complex, which creates holes in the cell membranes of bacteria, leading to their lysis (destruction).
4. Antibody-dependent cellular cytotoxicity (ADCC): IgG can bind to immune cells like natural killer (NK) cells and trigger them to release substances that cause target cells (such as virus-infected or cancerous cells) to undergo apoptosis (programmed cell death).
5. Immune complex formation: IgG can form immune complexes with antigens, which can then be removed from the body through various mechanisms, such as phagocytosis by immune cells or excretion in urine.

IgG is a critical component of adaptive immunity and provides long-lasting protection against reinfection with many pathogens. It has four subclasses (IgG1, IgG2, IgG3, and IgG4) that differ in their structure, function, and distribution in the body.

Patient-to-professional transmission of infectious diseases refers to the spread of an infectious agent or disease from a patient to a healthcare professional. This can occur through various routes, including:

1. Contact transmission: This includes direct contact, such as touching or shaking hands with an infected patient, or indirect contact, such as touching a contaminated surface or object.
2. Droplet transmission: This occurs when an infected person coughs, sneezes, talks, or breathes out droplets containing the infectious agent, which can then be inhaled by a nearby healthcare professional.
3. Airborne transmission: This involves the spread of infectious agents through the air over long distances, usually requiring specialized medical procedures or equipment.

Healthcare professionals are at risk of patient-to-professional transmission of infectious diseases due to their close contact with patients and the potential for exposure to various pathogens. It is essential for healthcare professionals to follow standard precautions, including hand hygiene, personal protective equipment (PPE), and respiratory protection, to minimize the risk of transmission. Additionally, proper vaccination and education on infection prevention and control measures can further reduce the risk of patient-to-professional transmission of infectious diseases.

Acute liver failure is a sudden and severe loss of liver function that occurs within a few days or weeks. It can be caused by various factors such as drug-induced liver injury, viral hepatitis, or metabolic disorders. In acute liver failure, the liver cannot perform its vital functions, including protein synthesis, detoxification, and metabolism of carbohydrates, fats, and proteins.

The symptoms of acute liver failure include jaundice (yellowing of the skin and eyes), coagulopathy (bleeding disorders), hepatic encephalopathy (neurological symptoms such as confusion, disorientation, and coma), and elevated levels of liver enzymes in the blood. Acute liver failure is a medical emergency that requires immediate hospitalization and treatment, which may include medications, supportive care, and liver transplantation.

Graft survival, in medical terms, refers to the success of a transplanted tissue or organ in continuing to function and integrate with the recipient's body over time. It is the opposite of graft rejection, which occurs when the recipient's immune system recognizes the transplanted tissue as foreign and attacks it, leading to its failure.

Graft survival depends on various factors, including the compatibility between the donor and recipient, the type and location of the graft, the use of immunosuppressive drugs to prevent rejection, and the overall health of the recipient. A successful graft survival implies that the transplanted tissue or organ has been accepted by the recipient's body and is functioning properly, providing the necessary physiological support for the recipient's survival and improved quality of life.

I'm sorry for any confusion, but "Italy" is not a medical term or concept. It is a country located in Southern Europe. If you have any questions related to medical terminology or health-related topics, I would be happy to try and help answer those for you.

Claudin-1 is a protein that is a member of the claudin family, which are important components of tight junctions in cells. Tight junctions are specialized structures that help to regulate the paracellular permeability of liquids and solutes between cells, and play a crucial role in maintaining cell polarity and tissue integrity. Claudin-1 is primarily expressed in epithelial and endothelial cells, where it helps to form tight junctions and regulate the movement of molecules across these barriers. Mutations in the gene that encodes claudin-1 have been associated with various human diseases, including skin disorders and cancer.

Virus receptors are specific molecules (commonly proteins) on the surface of host cells that viruses bind to in order to enter and infect those cells. This interaction between the virus and its receptor is a critical step in the infection process. Different types of viruses have different receptor requirements, and identifying these receptors can provide important insights into the biology of the virus and potential targets for antiviral therapies.

Alcoholic liver disease (ALD) is a term that encompasses a spectrum of liver disorders caused by excessive alcohol consumption. The three main stages of ALD are:

1. Fatty Liver: This is the earliest stage of ALD, characterized by the accumulation of fat droplets within liver cells (hepatocytes). It's often reversible with abstinence from alcohol.

2. Alcoholic Hepatitis: This is a more severe form of ALD, characterized by inflammation and damage to the liver cells. It can range from mild to severe, and severe cases can lead to liver failure. Symptoms may include jaundice, abdominal pain, and fever.

3. Cirrhosis: This is the most advanced stage of ALD, characterized by widespread scarring (fibrosis) and nodular transformation of the liver. It's irreversible and can lead to complications such as liver failure, portal hypertension, and increased risk of liver cancer.

The development and progression of ALD are influenced by various factors, including the amount and duration of alcohol consumption, genetic predisposition, nutritional status, and co-existing viral hepatitis or other liver diseases. Abstaining from alcohol is the most effective way to prevent and manage ALD.

Infectious canine hepatitis is a viral disease in dogs caused by canine adenovirus type 1 (CAV-1). The disease primarily affects the liver, but other organs such as the kidneys, eyes, and respiratory system may also be involved.

The virus is transmitted through direct contact with infected dogs or their urine, feces, saliva, or ocular/nasal discharge. It can also be spread through contaminated objects, water, or food. After infection, the virus incubates for 4-7 days before signs of illness appear.

Clinical signs of infectious canine hepatitis can vary widely in severity, from mild to severe. They may include fever, lethargy, loss of appetite, vomiting, diarrhea, abdominal pain, increased thirst and urination, jaundice (yellowing of the skin, mucous membranes, and whites of the eyes), and cloudiness or bluish discoloration of the cornea. In severe cases, neurological signs such as seizures or coma may occur.

Treatment for infectious canine hepatitis is primarily supportive, as there is no specific antiviral therapy available. Treatment may include fluid therapy to maintain hydration and electrolyte balance, nutritional support, medications to control vomiting and diarrhea, and management of any secondary bacterial infections that may develop.

Prevention of infectious canine hepatitis is achieved through vaccination with a modified-live or inactivated vaccine containing CAV-1. Puppies should receive their first vaccination at 6-8 weeks of age, followed by a booster at 10-12 weeks and another booster at 14-16 weeks. Annual revaccination is recommended to maintain immunity.

Hepadnaviridae is a family of viruses that primarily infect the liver of various species, including humans. The most well-known member of this family is the hepatitis B virus (HBV), which causes serious human disease.

Hepadnaviridae infections, specifically HBV infection, can lead to a range of clinical manifestations, from acute self-limiting hepatitis to chronic liver inflammation, fibrosis, cirrhosis, and even hepatocellular carcinoma (liver cancer). The virus is transmitted through contact with infected blood or other bodily fluids, as well as during childbirth from an infected mother to her newborn.

The infection process begins when the viral envelope proteins bind to specific receptors on the surface of hepatocytes, allowing the virus to enter the cell. Once inside, the viral DNA is released and converted into a covalently closed circular DNA (cccDNA) form, which serves as the template for viral replication. The host's immune response plays a crucial role in controlling the infection, but in some cases, it may also contribute to liver damage.

Prevention measures include vaccination against HBV and safe practices to avoid exposure to infected blood or bodily fluids. Treatment options for chronic HBV infection include antiviral medications that can suppress viral replication and reduce the risk of liver complications.

"Age factors" refer to the effects, changes, or differences that age can have on various aspects of health, disease, and medical care. These factors can encompass a wide range of issues, including:

1. Physiological changes: As people age, their bodies undergo numerous physical changes that can affect how they respond to medications, illnesses, and medical procedures. For example, older adults may be more sensitive to certain drugs or have weaker immune systems, making them more susceptible to infections.
2. Chronic conditions: Age is a significant risk factor for many chronic diseases, such as heart disease, diabetes, cancer, and arthritis. As a result, age-related medical issues are common and can impact treatment decisions and outcomes.
3. Cognitive decline: Aging can also lead to cognitive changes, including memory loss and decreased decision-making abilities. These changes can affect a person's ability to understand and comply with medical instructions, leading to potential complications in their care.
4. Functional limitations: Older adults may experience physical limitations that impact their mobility, strength, and balance, increasing the risk of falls and other injuries. These limitations can also make it more challenging for them to perform daily activities, such as bathing, dressing, or cooking.
5. Social determinants: Age-related factors, such as social isolation, poverty, and lack of access to transportation, can impact a person's ability to obtain necessary medical care and affect their overall health outcomes.

Understanding age factors is critical for healthcare providers to deliver high-quality, patient-centered care that addresses the unique needs and challenges of older adults. By taking these factors into account, healthcare providers can develop personalized treatment plans that consider a person's age, physical condition, cognitive abilities, and social circumstances.

Interferon-gamma (IFN-γ) is a soluble cytokine that is primarily produced by the activation of natural killer (NK) cells and T lymphocytes, especially CD4+ Th1 cells and CD8+ cytotoxic T cells. It plays a crucial role in the regulation of the immune response against viral and intracellular bacterial infections, as well as tumor cells. IFN-γ has several functions, including activating macrophages to enhance their microbicidal activity, increasing the presentation of major histocompatibility complex (MHC) class I and II molecules on antigen-presenting cells, stimulating the proliferation and differentiation of T cells and NK cells, and inducing the production of other cytokines and chemokines. Additionally, IFN-γ has direct antiproliferative effects on certain types of tumor cells and can enhance the cytotoxic activity of immune cells against infected or malignant cells.

Medical mass screening, also known as population screening, is a public health service that aims to identify and detect asymptomatic individuals in a given population who have or are at risk of a specific disease. The goal is to provide early treatment, reduce morbidity and mortality, and prevent the spread of diseases within the community.

A mass screening program typically involves offering a simple, quick, and non-invasive test to a large number of people in a defined population, regardless of their risk factors or symptoms. Those who test positive are then referred for further diagnostic tests and appropriate medical interventions. Examples of mass screening programs include mammography for breast cancer detection, PSA (prostate-specific antigen) testing for prostate cancer, and fecal occult blood testing for colorectal cancer.

It is important to note that mass screening programs should be evidence-based, cost-effective, and ethically sound, with clear benefits outweighing potential harms. They should also consider factors such as the prevalence of the disease in the population, the accuracy and reliability of the screening test, and the availability and effectiveness of treatment options.

Immunoglobulin M (IgM) is a type of antibody that is primarily found in the blood and lymph fluid. It is the first antibody to be produced in response to an initial exposure to an antigen, making it an important part of the body's primary immune response. IgM antibodies are large molecules that are composed of five basic units, giving them a pentameric structure. They are primarily found on the surface of B cells as membrane-bound immunoglobulins (mlgM), where they function as receptors for antigens. Once an mlgM receptor binds to an antigen, it triggers the activation and differentiation of the B cell into a plasma cell that produces and secretes large amounts of soluble IgM antibodies.

IgM antibodies are particularly effective at agglutination (clumping) and complement activation, which makes them important in the early stages of an immune response to help clear pathogens from the bloodstream. However, they are not as stable or long-lived as other types of antibodies, such as IgG, and their levels tend to decline after the initial immune response has occurred.

In summary, Immunoglobulin M (IgM) is a type of antibody that plays a crucial role in the primary immune response to antigens by agglutination and complement activation. It is primarily found in the blood and lymph fluid, and it is produced by B cells after they are activated by an antigen.

A tissue donor is an individual who has agreed to allow organs and tissues to be removed from their body after death for the purpose of transplantation to restore the health or save the life of another person. The tissues that can be donated include corneas, heart valves, skin, bone, tendons, ligaments, veins, and cartilage. These tissues can enhance the quality of life for many recipients and are often used in reconstructive surgeries. It is important to note that tissue donation does not interfere with an open casket funeral or other cultural or religious practices related to death and grieving.

I'm sorry for any confusion, but "Taiwan" is not a medical term or concept. It is the name of an island nation located in East Asia. The official name of the country is the Republic of China (ROC). If you have any medical questions or inquiries, I would be happy to help answer those for you!

CD (cluster of differentiation) antigens are cell-surface proteins that are expressed on leukocytes (white blood cells) and can be used to identify and distinguish different subsets of these cells. They are important markers in the field of immunology and hematology, and are commonly used to diagnose and monitor various diseases, including cancer, autoimmune disorders, and infectious diseases.

CD antigens are designated by numbers, such as CD4, CD8, CD19, etc., which refer to specific proteins found on the surface of different types of leukocytes. For example, CD4 is a protein found on the surface of helper T cells, while CD8 is found on cytotoxic T cells.

CD antigens can be used as targets for immunotherapy, such as monoclonal antibody therapy, in which antibodies are designed to bind to specific CD antigens and trigger an immune response against cancer cells or infected cells. They can also be used as markers to monitor the effectiveness of treatments and to detect minimal residual disease (MRD) after treatment.

It's important to note that not all CD antigens are exclusive to leukocytes, some can be found on other cell types as well, and their expression can vary depending on the activation state or differentiation stage of the cells.

Interferon-beta (IFN-β) is a type of cytokine - specifically, it's a protein that is produced and released by cells in response to stimulation by a virus or other foreign substance. It belongs to the interferon family of cytokines, which play important roles in the body's immune response to infection.

IFN-β has antiviral properties and helps to regulate the immune system. It works by binding to specific receptors on the surface of cells, which triggers a signaling cascade that leads to the activation of genes involved in the antiviral response. This results in the production of proteins that inhibit viral replication and promote the death of infected cells.

IFN-β is used as a medication for the treatment of certain autoimmune diseases, such as multiple sclerosis (MS). In MS, the immune system mistakenly attacks the protective coating around nerve fibers in the brain and spinal cord, causing inflammation and damage to the nerves. IFN-β has been shown to reduce the frequency and severity of relapses in people with MS, possibly by modulating the immune response and reducing inflammation.

It's important to note that while IFN-β is an important component of the body's natural defense system, it can also have side effects when used as a medication. Common side effects of IFN-β therapy include flu-like symptoms such as fever, chills, and muscle aches, as well as injection site reactions. More serious side effects are rare but can occur, so it's important to discuss the risks and benefits of this treatment with a healthcare provider.

Graft rejection is an immune response that occurs when transplanted tissue or organ (the graft) is recognized as foreign by the recipient's immune system, leading to the activation of immune cells to attack and destroy the graft. This results in the failure of the transplant and the need for additional medical intervention or another transplant. There are three types of graft rejection: hyperacute, acute, and chronic. Hyperacute rejection occurs immediately or soon after transplantation due to pre-existing antibodies against the graft. Acute rejection typically occurs within weeks to months post-transplant and is characterized by the infiltration of T-cells into the graft. Chronic rejection, which can occur months to years after transplantation, is a slow and progressive process characterized by fibrosis and tissue damage due to ongoing immune responses against the graft.

CD8-positive T-lymphocytes, also known as CD8+ T cells or cytotoxic T cells, are a type of white blood cell that plays a crucial role in the adaptive immune system. They are named after the CD8 molecule found on their surface, which is a protein involved in cell signaling and recognition.

CD8+ T cells are primarily responsible for identifying and destroying virus-infected cells or cancerous cells. When activated, they release cytotoxic granules that contain enzymes capable of inducing apoptosis (programmed cell death) in the target cells. They also produce cytokines such as interferon-gamma, which can help coordinate the immune response and activate other immune cells.

CD8+ T cells are generated in the thymus gland and are a type of T cell, which is a lymphocyte that matures in the thymus and plays a central role in cell-mediated immunity. They recognize and respond to specific antigens presented on the surface of infected or cancerous cells in conjunction with major histocompatibility complex (MHC) class I molecules.

Overall, CD8+ T cells are an essential component of the immune system's defense against viral infections and cancer.

Serum, in the context of clinical and medical laboratory science, refers to the fluid that is obtained after blood coagulation. It is the yellowish, straw-colored liquid fraction of whole blood that remains after the clotting factors have been removed. Serum contains various proteins, electrolytes, hormones, antibodies, antigens, and other substances, which can be analyzed to help diagnose and monitor a wide range of medical conditions. It is commonly used for various clinical tests such as chemistry panels, immunological assays, drug screening, and infectious disease testing.

A disease outbreak is defined as the occurrence of cases of a disease in excess of what would normally be expected in a given time and place. It may affect a small and localized group or a large number of people spread over a wide area, even internationally. An outbreak may be caused by a new agent, a change in the agent's virulence or host susceptibility, or an increase in the size or density of the host population.

Outbreaks can have significant public health and economic impacts, and require prompt investigation and control measures to prevent further spread of the disease. The investigation typically involves identifying the source of the outbreak, determining the mode of transmission, and implementing measures to interrupt the chain of infection. This may include vaccination, isolation or quarantine, and education of the public about the risks and prevention strategies.

Examples of disease outbreaks include foodborne illnesses linked to contaminated food or water, respiratory infections spread through coughing and sneezing, and mosquito-borne diseases such as Zika virus and West Nile virus. Outbreaks can also occur in healthcare settings, such as hospitals and nursing homes, where vulnerable populations may be at increased risk of infection.

'Infectious disease transmission, professional-to-patient' refers to the spread of an infectious agent or disease from a healthcare professional to a patient within a healthcare setting. This can occur through various routes such as:

1. Direct contact transmission: This involves physical contact between the healthcare professional and the patient, which may result in the transfer of microorganisms. Examples include touching, coughing, or sneezing on the patient.

2. Indirect contact transmission: This occurs when a healthcare professional contaminates an object or surface that is then touched by the patient, leading to the spread of infection. Common examples include contaminated medical equipment, bed rails, or doorknobs.

3. Droplet transmission: This type of transmission occurs when an infected individual generates respiratory droplets containing microorganisms, which can then be dispersed through the air and inhaled by a susceptible host. Healthcare professionals can transmit infectious diseases to patients via this route if they have close contact (within 1 meter) with the patient during procedures that generate aerosols or when coughing or sneezing.

4. Airborne transmission: This occurs when microorganisms are suspended in air and transmitted over long distances. Healthcare professionals can become sources of airborne infections through activities such as suctioning, endotracheal intubation, bronchoscopy, or cardiopulmonary resuscitation.

To prevent professional-to-patient transmission of infectious diseases, healthcare professionals should adhere to standard precautions, including hand hygiene, use of personal protective equipment (PPE), safe injection practices, and environmental cleaning and disinfection. Additionally, they should be vaccinated against vaccine-preventable diseases and follow respiratory etiquette, such as wearing masks and covering their mouths and noses when coughing or sneezing.

I cannot provide a medical definition for "equipment reuse" as it is not a term that is commonly used in the medical field. However, I can give you some general information about equipment reuse in healthcare settings.

Equipment reuse refers to the practice of using previously owned or disposable medical equipment and supplies multiple times after they have been sterilized or disinfected according to established protocols. This practice is often adopted by healthcare facilities as a way to reduce costs, conserve resources, and minimize waste.

Examples of medical equipment that may be reused include anesthesia breathing circuits, blood pressure cuffs, stethoscopes, and electronic thermometers. It's important to note that any reprocessed or reused medical equipment must undergo strict cleaning, disinfection, and sterilization procedures to ensure the safety of patients and healthcare workers.

Reusing medical equipment can have benefits such as reducing costs and waste, but it also carries risks if not done properly. Proper training and adherence to established protocols are crucial to ensuring that reused equipment is safe for use.

Silymarin is not a medical term itself, but it's the active compound found in the milk thistle plant (Silybum marianum). Medically, silymarin is often referred to as a standardized extract from the seeds of the milk thistle plant. It is a complex mixture of flavonolignans, mainly consisting of silybin, isosilybin, silychristin, and silydianin.

Silymarin has been reported to have various biological activities, including antioxidant, anti-inflammatory, and hepatoprotective effects. It is commonly used in complementary and alternative medicine for the treatment of liver diseases such as hepatitis, cirrhosis, and toxic liver damage due to alcohol or drug abuse. However, its clinical efficacy remains a subject of ongoing research and debate among medical professionals.

Logistic models, specifically logistic regression models, are a type of statistical analysis used in medical and epidemiological research to identify the relationship between the risk of a certain health outcome or disease (dependent variable) and one or more independent variables, such as demographic factors, exposure variables, or other clinical measurements.

In contrast to linear regression models, logistic regression models are used when the dependent variable is binary or dichotomous in nature, meaning it can only take on two values, such as "disease present" or "disease absent." The model uses a logistic function to estimate the probability of the outcome based on the independent variables.

Logistic regression models are useful for identifying risk factors and estimating the strength of associations between exposures and health outcomes, adjusting for potential confounders, and predicting the probability of an outcome given certain values of the independent variables. They can also be used to develop clinical prediction rules or scores that can aid in decision-making and patient care.

I'm sorry for any confusion, but "Romania" is not a medical term. It is a country located in southeastern Europe. If you have any questions about medical terminology or health-related topics, I would be happy to help. Could you please clarify your question?

Oligopeptides are defined in medicine and biochemistry as short chains of amino acids, typically containing fewer than 20 amino acid residues. These small peptides are important components in various biological processes, such as serving as signaling molecules, enzyme inhibitors, or structural elements in some proteins. They can be found naturally in foods and may also be synthesized for use in medical research and therapeutic applications.

Reverse Transcriptase Inhibitors (RTIs) are a class of antiretroviral drugs that are primarily used in the treatment and management of HIV (Human Immunodeficiency Virus) infection. They work by inhibiting the reverse transcriptase enzyme, which is essential for the replication of HIV.

HIV is a retrovirus, meaning it has an RNA genome and uses a unique enzyme called reverse transcriptase to convert its RNA into DNA. This process is necessary for the virus to integrate into the host cell's genome and replicate. Reverse Transcriptase Inhibitors interfere with this process by binding to the reverse transcriptase enzyme, preventing it from converting the viral RNA into DNA.

RTIs can be further divided into two categories: nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). NRTIs are analogs of the building blocks of DNA, which get incorporated into the growing DNA chain during replication, causing termination of the chain. NNRTIs bind directly to the reverse transcriptase enzyme, causing a conformational change that prevents it from functioning.

By inhibiting the reverse transcriptase enzyme, RTIs can prevent the virus from replicating and reduce the viral load in an infected individual, thereby slowing down the progression of HIV infection and AIDS (Acquired Immunodeficiency Syndrome).

A plasmid is a small, circular, double-stranded DNA molecule that is separate from the chromosomal DNA of a bacterium or other organism. Plasmids are typically not essential for the survival of the organism, but they can confer beneficial traits such as antibiotic resistance or the ability to degrade certain types of pollutants.

Plasmids are capable of replicating independently of the chromosomal DNA and can be transferred between bacteria through a process called conjugation. They often contain genes that provide resistance to antibiotics, heavy metals, and other environmental stressors. Plasmids have also been engineered for use in molecular biology as cloning vectors, allowing scientists to replicate and manipulate specific DNA sequences.

Plasmids are important tools in genetic engineering and biotechnology because they can be easily manipulated and transferred between organisms. They have been used to produce vaccines, diagnostic tests, and genetically modified organisms (GMOs) for various applications, including agriculture, medicine, and industry.

In the context of medical and biological sciences, a "binding site" refers to a specific location on a protein, molecule, or cell where another molecule can attach or bind. This binding interaction can lead to various functional changes in the original protein or molecule. The other molecule that binds to the binding site is often referred to as a ligand, which can be a small molecule, ion, or even another protein.

The binding between a ligand and its target binding site can be specific and selective, meaning that only certain ligands can bind to particular binding sites with high affinity. This specificity plays a crucial role in various biological processes, such as signal transduction, enzyme catalysis, or drug action.

In the case of drug development, understanding the location and properties of binding sites on target proteins is essential for designing drugs that can selectively bind to these sites and modulate protein function. This knowledge can help create more effective and safer therapeutic options for various diseases.

Antiretroviral Therapy, Highly Active (HAART) is a medical treatment regimen used to manage HIV infection. It involves the combination of three or more antiretroviral drugs from at least two different classes, aiming to maximally suppress viral replication and prevent the development of drug resistance. The goal of HAART is to reduce the amount of HIV in the body to undetectable levels, preserve immune function, and improve quality of life for people living with HIV. Commonly used antiretroviral classes include nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), integrase strand transfer inhibitors (INSTIs), and fusion inhibitors.

A CD4 lymphocyte count is a laboratory test that measures the number of CD4 T-cells (also known as CD4+ T-cells or helper T-cells) in a sample of blood. CD4 cells are a type of white blood cell that plays a crucial role in the body's immune response, particularly in fighting off infections caused by viruses and other pathogens.

CD4 cells express a protein on their surface called the CD4 receptor, which is used by human immunodeficiency virus (HIV) to infect and destroy these cells. As a result, people with HIV infection or AIDS often have low CD4 lymphocyte counts, which can make them more susceptible to opportunistic infections and other complications.

A normal CD4 lymphocyte count ranges from 500 to 1,200 cells per cubic millimeter of blood (cells/mm3) in healthy adults. A lower than normal CD4 count is often used as a marker for the progression of HIV infection and the development of AIDS. CD4 counts are typically monitored over time to assess the effectiveness of antiretroviral therapy (ART) and to guide clinical decision-making regarding the need for additional interventions, such as prophylaxis against opportunistic infections.

Interferon type I is a class of signaling proteins, also known as cytokines, that are produced and released by cells in response to the presence of pathogens such as viruses, bacteria, and parasites. These interferons play a crucial role in the body's innate immune system and help to establish an antiviral state in surrounding cells to prevent the spread of infection.

Interferon type I includes several subtypes, such as interferon-alpha (IFN-α), interferon-beta (IFN-β), and interferon-omega (IFN-ω). When produced, these interferons bind to specific receptors on the surface of nearby cells, triggering a cascade of intracellular signaling events that lead to the activation of genes involved in the antiviral response.

The activation of these genes results in the production of enzymes that inhibit viral replication and promote the destruction of infected cells. Interferon type I also enhances the adaptive immune response by promoting the activation and proliferation of immune cells such as T-cells and natural killer (NK) cells, which can directly target and eliminate infected cells.

Overall, interferon type I plays a critical role in the body's defense against viral infections and is an important component of the immune response to many different types of pathogens.

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome associated with liver dysfunction and/or portosystemic shunting. It results from the accumulation of toxic substances, such as ammonia and inflammatory mediators, which are normally metabolized by the liver. HE can present with a wide range of symptoms, including changes in sleep-wake cycle, altered mental status, confusion, disorientation, asterixis (flapping tremor), and in severe cases, coma. The diagnosis is based on clinical evaluation, neuropsychological testing, and exclusion of other causes of cognitive impairment. Treatment typically involves addressing the underlying liver dysfunction, reducing ammonia production through dietary modifications and medications, and preventing further episodes with lactulose or rifaximin therapy.

Comorbidity is the presence of one or more additional health conditions or diseases alongside a primary illness or condition. These co-occurring health issues can have an impact on the treatment plan, prognosis, and overall healthcare management of an individual. Comorbidities often interact with each other and the primary condition, leading to more complex clinical situations and increased healthcare needs. It is essential for healthcare professionals to consider and address comorbidities to provide comprehensive care and improve patient outcomes.

Autoantibodies are defined as antibodies that are produced by the immune system and target the body's own cells, tissues, or organs. These antibodies mistakenly identify certain proteins or molecules in the body as foreign invaders and attack them, leading to an autoimmune response. Autoantibodies can be found in various autoimmune diseases such as rheumatoid arthritis, lupus, and thyroiditis. The presence of autoantibodies can also be used as a diagnostic marker for certain conditions.

"Cells, cultured" is a medical term that refers to cells that have been removed from an organism and grown in controlled laboratory conditions outside of the body. This process is called cell culture and it allows scientists to study cells in a more controlled and accessible environment than they would have inside the body. Cultured cells can be derived from a variety of sources, including tissues, organs, or fluids from humans, animals, or cell lines that have been previously established in the laboratory.

Cell culture involves several steps, including isolation of the cells from the tissue, purification and characterization of the cells, and maintenance of the cells in appropriate growth conditions. The cells are typically grown in specialized media that contain nutrients, growth factors, and other components necessary for their survival and proliferation. Cultured cells can be used for a variety of purposes, including basic research, drug development and testing, and production of biological products such as vaccines and gene therapies.

It is important to note that cultured cells may behave differently than they do in the body, and results obtained from cell culture studies may not always translate directly to human physiology or disease. Therefore, it is essential to validate findings from cell culture experiments using additional models and ultimately in clinical trials involving human subjects.

Biliary cirrhosis is a specific type of liver cirrhosis that results from chronic inflammation and scarring of the bile ducts, leading to impaired bile flow, liver damage, and fibrosis. It can be further classified into primary biliary cholangitis (PBC) and secondary biliary cirrhosis. PBC is an autoimmune disease, while secondary biliary cirrhosis is often associated with chronic gallstones, biliary tract obstruction, or recurrent pyogenic cholangitis. Symptoms may include fatigue, itching, jaundice, and abdominal discomfort. Diagnosis typically involves blood tests, imaging studies, and sometimes liver biopsy. Treatment focuses on managing symptoms, slowing disease progression, and preventing complications.

I'm sorry for any confusion, but "Japan" is not a medical term. Japan is the name of a country, officially known as Nippon-koku or Nihon-koku in Japanese, and is located in East Asia. It is an island nation in the Pacific Ocean with a population of about 126 million people.

If you have any medical questions or terms that you would like me to define, please let me know!

Recombinant fusion proteins are artificially created biomolecules that combine the functional domains or properties of two or more different proteins into a single protein entity. They are generated through recombinant DNA technology, where the genes encoding the desired protein domains are linked together and expressed as a single, chimeric gene in a host organism, such as bacteria, yeast, or mammalian cells.

The resulting fusion protein retains the functional properties of its individual constituent proteins, allowing for novel applications in research, diagnostics, and therapeutics. For instance, recombinant fusion proteins can be designed to enhance protein stability, solubility, or immunogenicity, making them valuable tools for studying protein-protein interactions, developing targeted therapies, or generating vaccines against infectious diseases or cancer.

Examples of recombinant fusion proteins include:

1. Etaglunatide (ABT-523): A soluble Fc fusion protein that combines the heavy chain fragment crystallizable region (Fc) of an immunoglobulin with the extracellular domain of the human interleukin-6 receptor (IL-6R). This fusion protein functions as a decoy receptor, neutralizing IL-6 and its downstream signaling pathways in rheumatoid arthritis.
2. Etanercept (Enbrel): A soluble TNF receptor p75 Fc fusion protein that binds to tumor necrosis factor-alpha (TNF-α) and inhibits its proinflammatory activity, making it a valuable therapeutic option for treating autoimmune diseases like rheumatoid arthritis, ankylosing spondylitis, and psoriasis.
3. Abatacept (Orencia): A fusion protein consisting of the extracellular domain of cytotoxic T-lymphocyte antigen 4 (CTLA-4) linked to the Fc region of an immunoglobulin, which downregulates T-cell activation and proliferation in autoimmune diseases like rheumatoid arthritis.
4. Belimumab (Benlysta): A monoclonal antibody that targets B-lymphocyte stimulator (BLyS) protein, preventing its interaction with the B-cell surface receptor and inhibiting B-cell activation in systemic lupus erythematosus (SLE).
5. Romiplostim (Nplate): A fusion protein consisting of a thrombopoietin receptor agonist peptide linked to an immunoglobulin Fc region, which stimulates platelet production in patients with chronic immune thrombocytopenia (ITP).
6. Darbepoetin alfa (Aranesp): A hyperglycosylated erythropoiesis-stimulating protein that functions as a longer-acting form of recombinant human erythropoietin, used to treat anemia in patients with chronic kidney disease or cancer.
7. Palivizumab (Synagis): A monoclonal antibody directed against the F protein of respiratory syncytial virus (RSV), which prevents RSV infection and is administered prophylactically to high-risk infants during the RSV season.
8. Ranibizumab (Lucentis): A recombinant humanized monoclonal antibody fragment that binds and inhibits vascular endothelial growth factor A (VEGF-A), used in the treatment of age-related macular degeneration, diabetic retinopathy, and other ocular disorders.
9. Cetuximab (Erbitux): A chimeric monoclonal antibody that binds to epidermal growth factor receptor (EGFR), used in the treatment of colorectal cancer and head and neck squamous cell carcinoma.
10. Adalimumab (Humira): A fully humanized monoclonal antibody that targets tumor necrosis factor-alpha (TNF-α), used in the treatment of various inflammatory diseases, including rheumatoid arthritis, psoriasis, and Crohn's disease.
11. Bevacizumab (Avastin): A recombinant humanized monoclonal antibody that binds to VEGF-A, used in the treatment of various cancers, including colorectal, lung, breast, and kidney cancer.
12. Trastuzumab (Herceptin): A humanized monoclonal antibody that targets HER2/neu receptor, used in the treatment of breast cancer.
13. Rituximab (Rituxan): A chimeric monoclonal antibody that binds to CD20 antigen on B cells, used in the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis.
14. Palivizumab (Synagis): A humanized monoclonal antibody that binds to the F protein of respiratory syncytial virus, used in the prevention of respiratory syncytial virus infection in high-risk infants.
15. Infliximab (Remicade): A chimeric monoclonal antibody that targets TNF-α, used in the treatment of various inflammatory diseases, including Crohn's disease, ulcerative colitis, rheumatoid arthritis, and ankylosing spondylitis.
16. Natalizumab (Tysabri): A humanized monoclonal antibody that binds to α4β1 integrin, used in the treatment of multiple sclerosis and Crohn's disease.
17. Adalimumab (Humira): A fully human monoclonal antibody that targets TNF-α, used in the treatment of various inflammatory diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, and ulcerative colitis.
18. Golimumab (Simponi): A fully human monoclonal antibody that targets TNF-α, used in the treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis.
19. Certolizumab pegol (Cimzia): A PEGylated Fab' fragment of a humanized monoclonal antibody that targets TNF-α, used in the treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease.
20. Ustekinumab (Stelara): A fully human monoclonal antibody that targets IL-12 and IL-23, used in the treatment of psoriasis, psoriatic arthritis, and Crohn's disease.
21. Secukinumab (Cosentyx): A fully human monoclonal antibody that targets IL-17A, used in the treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis.
22. Ixekizumab (Taltz): A fully human monoclonal antibody that targets IL-17A, used in the treatment of psoriasis and psoriatic arthritis.
23. Brodalumab (Siliq): A fully human monoclonal antibody that targets IL-17 receptor A, used in the treatment of psoriasis.
24. Sarilumab (Kevzara): A fully human monoclonal antibody that targets the IL-6 receptor, used in the treatment of rheumatoid arthritis.
25. Tocilizumab (Actemra): A humanized monoclonal antibody that targets the IL-6 receptor, used in the treatment of rheumatoid arthritis, systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, giant cell arteritis, and chimeric antigen receptor T-cell-induced cytokine release syndrome.
26. Siltuximab (Sylvant): A chimeric monoclonal antibody that targets IL-6, used in the treatment of multicentric Castleman disease.
27. Satralizumab (Enspryng): A humanized monoclonal antibody that targets IL-6 receptor alpha, used in the treatment of neuromyelitis optica spectrum disorder.
28. Sirukumab (Plivensia): A human monoclonal antibody that targets IL-6, used in the treatment

Immunoblotting, also known as western blotting, is a laboratory technique used in molecular biology and immunogenetics to detect and quantify specific proteins in a complex mixture. This technique combines the electrophoretic separation of proteins by gel electrophoresis with their detection using antibodies that recognize specific epitopes (protein fragments) on the target protein.

The process involves several steps: first, the protein sample is separated based on size through sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Next, the separated proteins are transferred onto a nitrocellulose or polyvinylidene fluoride (PVDF) membrane using an electric field. The membrane is then blocked with a blocking agent to prevent non-specific binding of antibodies.

After blocking, the membrane is incubated with a primary antibody that specifically recognizes the target protein. Following this, the membrane is washed to remove unbound primary antibodies and then incubated with a secondary antibody conjugated to an enzyme such as horseradish peroxidase (HRP) or alkaline phosphatase (AP). The enzyme catalyzes a colorimetric or chemiluminescent reaction that allows for the detection of the target protein.

Immunoblotting is widely used in research and clinical settings to study protein expression, post-translational modifications, protein-protein interactions, and disease biomarkers. It provides high specificity and sensitivity, making it a valuable tool for identifying and quantifying proteins in various biological samples.

Molecular cloning is a laboratory technique used to create multiple copies of a specific DNA sequence. This process involves several steps:

1. Isolation: The first step in molecular cloning is to isolate the DNA sequence of interest from the rest of the genomic DNA. This can be done using various methods such as PCR (polymerase chain reaction), restriction enzymes, or hybridization.
2. Vector construction: Once the DNA sequence of interest has been isolated, it must be inserted into a vector, which is a small circular DNA molecule that can replicate independently in a host cell. Common vectors used in molecular cloning include plasmids and phages.
3. Transformation: The constructed vector is then introduced into a host cell, usually a bacterial or yeast cell, through a process called transformation. This can be done using various methods such as electroporation or chemical transformation.
4. Selection: After transformation, the host cells are grown in selective media that allow only those cells containing the vector to grow. This ensures that the DNA sequence of interest has been successfully cloned into the vector.
5. Amplification: Once the host cells have been selected, they can be grown in large quantities to amplify the number of copies of the cloned DNA sequence.

Molecular cloning is a powerful tool in molecular biology and has numerous applications, including the production of recombinant proteins, gene therapy, functional analysis of genes, and genetic engineering.

Hep G2 cells are a type of human liver cancer cell line that were isolated from a well-differentiated hepatocellular carcinoma (HCC) in a patient with hepatitis C virus (HCV) infection. These cells have the ability to grow and divide indefinitely in culture, making them useful for research purposes. Hep G2 cells express many of the same markers and functions as normal human hepatocytes, including the ability to take up and process lipids and produce bile. They are often used in studies related to hepatitis viruses, liver metabolism, drug toxicity, and cancer biology. It is important to note that Hep G2 cells are tumorigenic and should be handled with care in a laboratory setting.

Proline is an organic compound that is classified as a non-essential amino acid, meaning it can be produced by the human body and does not need to be obtained through the diet. It is encoded in the genetic code as the codon CCU, CCC, CCA, or CCG. Proline is a cyclic amino acid, containing an unusual secondary amine group, which forms a ring structure with its carboxyl group.

In proteins, proline acts as a structural helix breaker, disrupting the alpha-helix structure and leading to the formation of turns and bends in the protein chain. This property is important for the proper folding and function of many proteins. Proline also plays a role in the stability of collagen, a major structural protein found in connective tissues such as tendons, ligaments, and skin.

In addition to its role in protein structure, proline has been implicated in various cellular processes, including signal transduction, apoptosis, and oxidative stress response. It is also a precursor for the synthesis of other biologically important compounds such as hydroxyproline, which is found in collagen and elastin, and glutamate, an excitatory neurotransmitter in the brain.

Alpha-fetoprotein (AFP) is a protein produced by the yolk sac and the liver during fetal development. In adults, AFP is normally present in very low levels in the blood. However, abnormal production of AFP can occur in certain medical conditions, such as:

* Liver cancer or hepatocellular carcinoma (HCC)
* Germ cell tumors, including non-seminomatous testicular cancer and ovarian cancer
* Hepatitis or liver inflammation
* Certain types of benign liver disease, such as cirrhosis or hepatic adenomas

Elevated levels of AFP in the blood can be detected through a simple blood test. This test is often used as a tumor marker to help diagnose and monitor certain types of cancer, particularly HCC. However, it's important to note that an elevated AFP level alone is not enough to diagnose cancer, and further testing is usually needed to confirm the diagnosis. Additionally, some non-cancerous conditions can also cause elevated AFP levels, so it's important to interpret the test results in the context of the individual's medical history and other diagnostic tests.

Superinfection is a medical term that refers to a secondary infection which occurs during or following the treatment of an initial infection. This second infection is often caused by a different microorganism that is resistant to the medication used to treat the first infection. Superinfections can occur in various parts of the body, such as the skin, respiratory system, gastrointestinal tract, or urinary tract, and are more common in individuals with weakened immune systems, chronic illnesses, or those who have been on antibiotics for an extended period.

Superinfections can lead to more severe complications, prolonged hospital stays, increased healthcare costs, and higher mortality rates if not promptly diagnosed and treated appropriately. Healthcare providers must be vigilant in monitoring patients' responses to treatment and recognizing signs of superinfection, such as worsening symptoms or the development of new ones, to ensure timely intervention and optimal patient outcomes.

Neutralizing antibodies are a type of antibody that defends against pathogens such as viruses or bacteria by neutralizing their ability to infect cells. They do this by binding to specific regions on the surface proteins of the pathogen, preventing it from attaching to and entering host cells. This renders the pathogen ineffective and helps to prevent or reduce the severity of infection. Neutralizing antibodies can be produced naturally in response to an infection or vaccination, or they can be generated artificially for therapeutic purposes.

Membranoproliferative Glomerulonephritis (MPGN) is a type of glomerulonephritis, which is a group of kidney disorders characterized by inflammation and damage to the glomeruli, the tiny blood vessels in the kidneys responsible for filtering waste and excess fluids from the blood.

MPGN is specifically characterized by thickening of the glomerular basement membrane and proliferation (increased number) of cells in the mesangium, a region within the glomerulus. This condition can be primary or secondary to other diseases such as infections, autoimmune disorders, or monoclonal gammopathies.

MPGN is typically classified into three types based on the pattern of injury seen on electron microscopy: Type I, Type II (Dense Deposit Disease), and Type III. Each type has distinct clinical features, laboratory findings, and treatment approaches. Symptoms of MPGN may include hematuria (blood in urine), proteinuria (protein in urine), hypertension (high blood pressure), edema (swelling), and eventually progress to chronic kidney disease or end-stage renal disease if left untreated.

In genetics, sequence alignment is the process of arranging two or more DNA, RNA, or protein sequences to identify regions of similarity or homology between them. This is often done using computational methods to compare the nucleotide or amino acid sequences and identify matching patterns, which can provide insight into evolutionary relationships, functional domains, or potential genetic disorders. The alignment process typically involves adjusting gaps and mismatches in the sequences to maximize the similarity between them, resulting in an aligned sequence that can be visually represented and analyzed.

CD4-positive T-lymphocytes, also known as CD4+ T cells or helper T cells, are a type of white blood cell that plays a crucial role in the immune response. They express the CD4 receptor on their surface and help coordinate the immune system's response to infectious agents such as viruses and bacteria.

CD4+ T cells recognize and bind to specific antigens presented by antigen-presenting cells, such as dendritic cells or macrophages. Once activated, they can differentiate into various subsets of effector cells, including Th1, Th2, Th17, and Treg cells, each with distinct functions in the immune response.

CD4+ T cells are particularly important in the immune response to HIV (human immunodeficiency virus), which targets and destroys these cells, leading to a weakened immune system and increased susceptibility to opportunistic infections. The number of CD4+ T cells is often used as a marker of disease progression in HIV infection, with lower counts indicating more advanced disease.

Macrocyclic compounds are organic compounds containing a large ring structure, typically consisting of 12 or more atoms in the ring. These molecules can be found naturally occurring in some organisms, such as certain antibiotics and toxins, or they can be synthesized in the laboratory for various applications, including pharmaceuticals, catalysts, and materials science.

The term "macrocyclic" is used to distinguish these compounds from smaller ring structures, known as "cyclic" or "small-ring" compounds, which typically contain 5-7 atoms in the ring. Macrocyclic compounds can have a wide range of shapes and sizes, including crown ethers, cyclodextrins, calixarenes, and porphyrins, among others.

The unique structure of macrocyclic compounds often imparts special properties to them, such as the ability to bind selectively to specific ions or molecules, form stable complexes with metals, or act as catalysts for chemical reactions. These properties make macrocyclic compounds useful in a variety of applications, including drug delivery, chemical sensors, and environmental remediation.

Epitope mapping is a technique used in immunology to identify the specific portion or regions (called epitopes) on an antigen that are recognized and bind to antibodies or T-cell receptors. This process helps to understand the molecular basis of immune responses against various pathogens, allergens, or transplanted tissues.

Epitope mapping can be performed using different methods such as:

1. Peptide scanning: In this method, a series of overlapping peptides spanning the entire length of the antigen are synthesized and tested for their ability to bind to antibodies or T-cell receptors. The peptide that shows binding is considered to contain the epitope.
2. Site-directed mutagenesis: In this approach, specific amino acids within the antigen are altered, and the modified antigens are tested for their ability to bind to antibodies or T-cell receptors. This helps in identifying the critical residues within the epitope.
3. X-ray crystallography and NMR spectroscopy: These techniques provide detailed information about the three-dimensional structure of antigen-antibody complexes, allowing for accurate identification of epitopes at an atomic level.

The results from epitope mapping can be useful in various applications, including vaccine design, diagnostic test development, and understanding the basis of autoimmune diseases.

The Predictive Value of Tests, specifically the Positive Predictive Value (PPV) and Negative Predictive Value (NPV), are measures used in diagnostic tests to determine the probability that a positive or negative test result is correct.

Positive Predictive Value (PPV) is the proportion of patients with a positive test result who actually have the disease. It is calculated as the number of true positives divided by the total number of positive results (true positives + false positives). A higher PPV indicates that a positive test result is more likely to be a true positive, and therefore the disease is more likely to be present.

Negative Predictive Value (NPV) is the proportion of patients with a negative test result who do not have the disease. It is calculated as the number of true negatives divided by the total number of negative results (true negatives + false negatives). A higher NPV indicates that a negative test result is more likely to be a true negative, and therefore the disease is less likely to be present.

The predictive value of tests depends on the prevalence of the disease in the population being tested, as well as the sensitivity and specificity of the test. A test with high sensitivity and specificity will generally have higher predictive values than a test with low sensitivity and specificity. However, even a highly sensitive and specific test can have low predictive values if the prevalence of the disease is low in the population being tested.

Prognosis is a medical term that refers to the prediction of the likely outcome or course of a disease, including the chances of recovery or recurrence, based on the patient's symptoms, medical history, physical examination, and diagnostic tests. It is an important aspect of clinical decision-making and patient communication, as it helps doctors and patients make informed decisions about treatment options, set realistic expectations, and plan for future care.

Prognosis can be expressed in various ways, such as percentages, categories (e.g., good, fair, poor), or survival rates, depending on the nature of the disease and the available evidence. However, it is important to note that prognosis is not an exact science and may vary depending on individual factors, such as age, overall health status, and response to treatment. Therefore, it should be used as a guide rather than a definitive forecast.

Immune evasion is a term used in immunology to describe the various strategies employed by pathogens (such as viruses, bacteria, parasites) to avoid or subvert the host's immune system. This can include mechanisms that allow the pathogen to directly inhibit or escape the actions of immune cells, like T cells and neutrophils, or to prevent the detection of their presence by masking themselves from the immune system.

For example, some viruses may change their surface proteins to avoid recognition by antibodies, while others may block the presentation of their antigens to T cells. Similarly, some bacteria can produce enzymes that degrade or modify components of the immune system, allowing them to evade detection and destruction.

Immune evasion is a major challenge in the development of effective vaccines and therapies for infectious diseases, as it allows pathogens to persist and cause chronic infections. Understanding the mechanisms of immune evasion can help researchers develop strategies to overcome these challenges and improve outcomes for patients.

Glycyrrhizic acid is a compound derived from the root of the licorice plant (Glycyrrhiza glabra). It has been defined medically as a triterpene glycoside with anti-inflammatory and expectorant properties. It is known to inhibit the enzyme 11-beta-hydroxysteroid dehydrogenase, which can lead to increased levels of cortisol in the body, potentially causing side effects such as hypertension and hypokalemia if consumed in large amounts or over an extended period.

In some medical contexts, glycyrrhizic acid may be used for its potential benefits, including its ability to suppress viral replication and inflammation. However, due to the risk of side effects, it is often used in modified forms or at reduced concentrations.

T-lymphocytes, also known as T-cells, are a type of white blood cell that plays a key role in the adaptive immune system's response to infection. They are produced in the bone marrow and mature in the thymus gland. There are several different types of T-cells, including CD4+ helper T-cells, CD8+ cytotoxic T-cells, and regulatory T-cells (Tregs).

CD4+ helper T-cells assist in activating other immune cells, such as B-lymphocytes and macrophages. They also produce cytokines, which are signaling molecules that help coordinate the immune response. CD8+ cytotoxic T-cells directly kill infected cells by releasing toxic substances. Regulatory T-cells help maintain immune tolerance and prevent autoimmune diseases by suppressing the activity of other immune cells.

T-lymphocytes are important in the immune response to viral infections, cancer, and other diseases. Dysfunction or depletion of T-cells can lead to immunodeficiency and increased susceptibility to infections. On the other hand, an overactive T-cell response can contribute to autoimmune diseases and chronic inflammation.

Cyclophilins are a family of proteins that have peptidyl-prolyl isomerase activity, which means they help with the folding and functioning of other proteins in cells. They were first identified as binding proteins for the immunosuppressive drug cyclosporine A, hence their name.

Cyclophilins are found in various organisms, including humans, and play important roles in many cellular processes such as signal transduction, protein trafficking, and gene expression. In addition to their role in normal cell function, cyclophilins have also been implicated in several diseases, including viral infections, cancer, and neurodegenerative disorders.

In medicine, the most well-known use of cyclophilins is as a target for immunosuppressive drugs used in organ transplantation. Cyclosporine A and its derivatives work by binding to cyclophilins, which inhibits their activity and subsequently suppresses the immune response.

I'm sorry for any confusion, but "France" is not a medical term or concept. France is the largest country in Western Europe and the third-largest in Europe after Russia and Ukraine. It has been a major player in world affairs for centuries, with a significant cultural and artistic influence. If you have any questions about medical terms or concepts, I would be happy to help answer those for you.

Risk assessment in the medical context refers to the process of identifying, evaluating, and prioritizing risks to patients, healthcare workers, or the community related to healthcare delivery. It involves determining the likelihood and potential impact of adverse events or hazards, such as infectious diseases, medication errors, or medical devices failures, and implementing measures to mitigate or manage those risks. The goal of risk assessment is to promote safe and high-quality care by identifying areas for improvement and taking action to minimize harm.

Lichen Planus is a chronic, autoimmune skin condition that can also affect the mucous membranes inside the mouth, genitals, and eyes. It is characterized by the appearance of purplish, flat-topped bumps or lesions on the skin, which may be itchy. The exact cause of Lichen Planus is unknown, but it is believed to occur when the immune system mistakenly attacks cells in the skin or mucous membranes. Certain medications, viral infections, and genetic factors may increase the risk of developing this condition. Treatment typically focuses on managing symptoms and may include topical corticosteroids, oral medications, or light therapy.

'Tumor cells, cultured' refers to the process of removing cancerous cells from a tumor and growing them in controlled laboratory conditions. This is typically done by isolating the tumor cells from a patient's tissue sample, then placing them in a nutrient-rich environment that promotes their growth and multiplication.

The resulting cultured tumor cells can be used for various research purposes, including the study of cancer biology, drug development, and toxicity testing. They provide a valuable tool for researchers to better understand the behavior and characteristics of cancer cells outside of the human body, which can lead to the development of more effective cancer treatments.

It is important to note that cultured tumor cells may not always behave exactly the same way as they do in the human body, so findings from cell culture studies must be validated through further research, such as animal models or clinical trials.

A "Drug Administration Schedule" refers to the plan for when and how a medication should be given to a patient. It includes details such as the dose, frequency (how often it should be taken), route (how it should be administered, such as orally, intravenously, etc.), and duration (how long it should be taken) of the medication. This schedule is often created and prescribed by healthcare professionals, such as doctors or pharmacists, to ensure that the medication is taken safely and effectively. It may also include instructions for missed doses or changes in the dosage.

Gamma-glutamyltransferase (GGT), also known as gamma-glutamyl transpeptidase, is an enzyme found in many tissues, including the liver, bile ducts, and pancreas. GGT is involved in the metabolism of certain amino acids and plays a role in the detoxification of various substances in the body.

GGT is often measured as a part of a panel of tests used to evaluate liver function. Elevated levels of GGT in the blood may indicate liver disease or injury, bile duct obstruction, or alcohol consumption. However, it's important to note that several other factors can also affect GGT levels, so abnormal results should be interpreted in conjunction with other clinical findings and diagnostic tests.

Cytotoxic T-lymphocytes, also known as CD8+ T cells, are a type of white blood cell that plays a central role in the cell-mediated immune system. They are responsible for identifying and destroying virus-infected cells and cancer cells. When a cytotoxic T-lymphocyte recognizes a specific antigen presented on the surface of an infected or malignant cell, it becomes activated and releases toxic substances such as perforins and granzymes, which can create pores in the target cell's membrane and induce apoptosis (programmed cell death). This process helps to eliminate the infected or malignant cells and prevent the spread of infection or cancer.

Cyclophilin A is a type of intracellular protein that belongs to the immunophilin family. It has peptidyl-prolyl cis-trans isomerase activity, which means it helps in folding and assembling other proteins by catalyzing the cis-trans isomerization of proline residues.

Cyclophilin A is widely distributed in various tissues and cells, including immune cells such as T lymphocytes. It plays a crucial role in the immune system by binding to and activating the immunosuppressive drug cyclosporine A, which is used to prevent rejection of transplanted organs.

In addition to its role in protein folding and immunosuppression, Cyclophilin A has been implicated in various cellular processes such as signal transduction, gene expression, and apoptosis (programmed cell death). It also plays a role in viral replication, particularly of HIV-1, the virus that causes AIDS.

Messenger RNA (mRNA) is a type of RNA (ribonucleic acid) that carries genetic information copied from DNA in the form of a series of three-base code "words," each of which specifies a particular amino acid. This information is used by the cell's machinery to construct proteins, a process known as translation. After being transcribed from DNA, mRNA travels out of the nucleus to the ribosomes in the cytoplasm where protein synthesis occurs. Once the protein has been synthesized, the mRNA may be degraded and recycled. Post-transcriptional modifications can also occur to mRNA, such as alternative splicing and addition of a 5' cap and a poly(A) tail, which can affect its stability, localization, and translation efficiency.

A syringe is a medical device used to administer or withdraw fluids, typically liquids or gases. It consists of a narrow tube, usually made of plastic or glass, connected to a handle that contains a plunger. The plunger is used to draw fluid into the tube by creating a vacuum, and then to expel the fluid when pressure is applied to the plunger. Syringes come in various sizes and are used for a wide range of medical procedures, including injections, wound care, and specimen collection. They are an essential tool in the medical field and are used daily in hospitals, clinics, and other healthcare settings.

A nucleoside is a biochemical molecule that consists of a pentose sugar (a type of simple sugar with five carbon atoms) covalently linked to a nitrogenous base. The nitrogenous base can be one of several types, including adenine, guanine, cytosine, thymine, or uracil. Nucleosides are important components of nucleic acids, such as DNA and RNA, which are the genetic materials found in cells. They play a crucial role in various biological processes, including cell division, protein synthesis, and gene expression.

Protein precursors, also known as proproteins or prohormones, are inactive forms of proteins that undergo post-translational modification to become active. These modifications typically include cleavage of the precursor protein by specific enzymes, resulting in the release of the active protein. This process allows for the regulation and control of protein activity within the body. Protein precursors can be found in various biological processes, including the endocrine system where they serve as inactive hormones that can be converted into their active forms when needed.

Elasticity imaging techniques are non-invasive medical diagnostic methods used to evaluate the stiffness or elasticity of various tissues in the body, such as organs, muscles, and breast tissue. These techniques can help detect and diagnose abnormalities, including tumors, lesions, and other conditions that may affect tissue stiffness.

There are several types of elasticity imaging techniques, including:

1. Ultrasound Elastography: This technique uses ultrasound waves to apply pressure to tissues and measure their deformation or strain. The degree of deformation is then used to calculate the stiffness of the tissue.
2. Magnetic Resonance Elastography (MRE): MRE uses magnetic resonance imaging (MRI) to create images of tissue elasticity. A mechanical device is used to apply vibrations to the body, and the resulting motion is measured using MRI to determine tissue stiffness.
3. Shear Wave Elastography: This technique uses acoustic radiation force impulses to generate shear waves in tissues. The speed of these waves is then measured to calculate tissue stiffness.
4. Strain Imaging: This technique measures the amount of deformation or strain that occurs in tissues when they are compressed or stretched. It can be used to detect areas of increased stiffness, such as tumors or scar tissue.

Elasticity imaging techniques have several advantages over traditional diagnostic methods, including their non-invasive nature and ability to provide real-time images of tissue elasticity. They are also useful for monitoring changes in tissue stiffness over time, making them valuable tools for evaluating the effectiveness of treatments and monitoring disease progression.

Genetic transcription is the process by which the information in a strand of DNA is used to create a complementary RNA molecule. This process is the first step in gene expression, where the genetic code in DNA is converted into a form that can be used to produce proteins or functional RNAs.

During transcription, an enzyme called RNA polymerase binds to the DNA template strand and reads the sequence of nucleotide bases. As it moves along the template, it adds complementary RNA nucleotides to the growing RNA chain, creating a single-stranded RNA molecule that is complementary to the DNA template strand. Once transcription is complete, the RNA molecule may undergo further processing before it can be translated into protein or perform its functional role in the cell.

Transcription can be either "constitutive" or "regulated." Constitutive transcription occurs at a relatively constant rate and produces essential proteins that are required for basic cellular functions. Regulated transcription, on the other hand, is subject to control by various intracellular and extracellular signals, allowing cells to respond to changing environmental conditions or developmental cues.

Ribosomes are complex macromolecular structures composed of ribonucleic acid (RNA) and proteins that play a crucial role in protein synthesis within cells. They serve as the site for translation, where messenger RNA (mRNA) is translated into a specific sequence of amino acids to create a polypeptide chain, which eventually folds into a functional protein.

Ribosomes consist of two subunits: a smaller subunit and a larger subunit. These subunits are composed of ribosomal RNA (rRNA) molecules and proteins. In eukaryotic cells, the smaller subunit is denoted as the 40S subunit, while the larger subunit is referred to as the 60S subunit. In prokaryotic cells, these subunits are named the 30S and 50S subunits, respectively. The ribosome's overall structure resembles a "doughnut" or a "cotton reel," with grooves and binding sites for various factors involved in protein synthesis.

Ribosomes can be found floating freely within the cytoplasm of cells or attached to the endoplasmic reticulum (ER) membrane, forming part of the rough ER. Membrane-bound ribosomes are responsible for synthesizing proteins that will be transported across the ER and ultimately secreted from the cell or inserted into the membrane. In contrast, cytoplasmic ribosomes synthesize proteins destined for use within the cytoplasm or organelles.

In summary, ribosomes are essential components of cells that facilitate protein synthesis by translating mRNA into functional polypeptide chains. They can be found in various cellular locations and exist as either free-floating entities or membrane-bound structures.

Synthetic vaccines are artificially produced, designed to stimulate an immune response and provide protection against specific diseases. Unlike traditional vaccines that are derived from weakened or killed pathogens, synthetic vaccines are created using synthetic components, such as synthesized viral proteins, DNA, or RNA. These components mimic the disease-causing agent and trigger an immune response without causing the actual disease. The use of synthetic vaccines offers advantages in terms of safety, consistency, and scalability in production, making them valuable tools for preventing infectious diseases.

A platelet count is a laboratory test that measures the number of platelets, also known as thrombocytes, in a sample of blood. Platelets are small, colorless cell fragments that circulate in the blood and play a crucial role in blood clotting. They help to stop bleeding by sticking together to form a plug at the site of an injured blood vessel.

A normal platelet count ranges from 150,000 to 450,000 platelets per microliter (µL) of blood. A lower than normal platelet count is called thrombocytopenia, while a higher than normal platelet count is known as thrombocytosis.

Abnormal platelet counts can be a sign of various medical conditions, including bleeding disorders, infections, certain medications, and some types of cancer. It is important to consult with a healthcare provider if you have any concerns about your platelet count or if you experience symptoms such as easy bruising, prolonged bleeding, or excessive menstrual flow.

Reproducibility of results in a medical context refers to the ability to obtain consistent and comparable findings when a particular experiment or study is repeated, either by the same researcher or by different researchers, following the same experimental protocol. It is an essential principle in scientific research that helps to ensure the validity and reliability of research findings.

In medical research, reproducibility of results is crucial for establishing the effectiveness and safety of new treatments, interventions, or diagnostic tools. It involves conducting well-designed studies with adequate sample sizes, appropriate statistical analyses, and transparent reporting of methods and findings to allow other researchers to replicate the study and confirm or refute the results.

The lack of reproducibility in medical research has become a significant concern in recent years, as several high-profile studies have failed to produce consistent findings when replicated by other researchers. This has led to increased scrutiny of research practices and a call for greater transparency, rigor, and standardization in the conduct and reporting of medical research.

The Chi-square distribution is a continuous probability distribution that is often used in statistical hypothesis testing. It is the distribution of a sum of squares of k independent standard normal random variables. The resulting quantity follows a chi-square distribution with k degrees of freedom, denoted as χ²(k).

The probability density function (pdf) of the Chi-square distribution with k degrees of freedom is given by:

f(x; k) = (1/ (2^(k/2) * Γ(k/2))) \* x^((k/2)-1) \* e^(-x/2), for x > 0 and 0, otherwise.

Where Γ(k/2) is the gamma function evaluated at k/2. The mean and variance of a Chi-square distribution with k degrees of freedom are k and 2k, respectively.

The Chi-square distribution has various applications in statistical inference, including testing goodness-of-fit, homogeneity of variances, and independence in contingency tables.

Monoclonal antibodies are a type of antibody that are identical because they are produced by a single clone of cells. They are laboratory-produced molecules that act like human antibodies in the immune system. They can be designed to attach to specific proteins found on the surface of cancer cells, making them useful for targeting and treating cancer. Monoclonal antibodies can also be used as a therapy for other diseases, such as autoimmune disorders and inflammatory conditions.

Monoclonal antibodies are produced by fusing a single type of immune cell, called a B cell, with a tumor cell to create a hybrid cell, or hybridoma. This hybrid cell is then able to replicate indefinitely, producing a large number of identical copies of the original antibody. These antibodies can be further modified and engineered to enhance their ability to bind to specific targets, increase their stability, and improve their effectiveness as therapeutic agents.

Monoclonal antibodies have several mechanisms of action in cancer therapy. They can directly kill cancer cells by binding to them and triggering an immune response. They can also block the signals that promote cancer growth and survival. Additionally, monoclonal antibodies can be used to deliver drugs or radiation directly to cancer cells, increasing the effectiveness of these treatments while minimizing their side effects on healthy tissues.

Monoclonal antibodies have become an important tool in modern medicine, with several approved for use in cancer therapy and other diseases. They are continuing to be studied and developed as a promising approach to treating a wide range of medical conditions.

Nonparametric statistics is a branch of statistics that does not rely on assumptions about the distribution of variables in the population from which the sample is drawn. In contrast to parametric methods, nonparametric techniques make fewer assumptions about the data and are therefore more flexible in their application. Nonparametric tests are often used when the data do not meet the assumptions required for parametric tests, such as normality or equal variances.

Nonparametric statistical methods include tests such as the Wilcoxon rank-sum test (also known as the Mann-Whitney U test) for comparing two independent groups, the Wilcoxon signed-rank test for comparing two related groups, and the Kruskal-Wallis test for comparing more than two independent groups. These tests use the ranks of the data rather than the actual values to make comparisons, which allows them to be used with ordinal or continuous data that do not meet the assumptions of parametric tests.

Overall, nonparametric statistics provide a useful set of tools for analyzing data in situations where the assumptions of parametric methods are not met, and can help researchers draw valid conclusions from their data even when the data are not normally distributed or have other characteristics that violate the assumptions of parametric tests.

Molecular epidemiology is a branch of epidemiology that uses laboratory techniques to identify and analyze the genetic material (DNA, RNA) of pathogens or host cells to understand their distribution, transmission, and disease associations in populations. It combines molecular biology methods with epidemiological approaches to investigate the role of genetic factors in disease occurrence and outcomes. This field has contributed significantly to the identification of infectious disease outbreaks, tracking the spread of antibiotic-resistant bacteria, understanding the transmission dynamics of viruses, and identifying susceptible populations for targeted interventions.

In the context of medicine, risk-taking refers to the decision-making process where an individual or a healthcare provider knowingly engages in an activity or continues a course of treatment despite the potential for negative outcomes or complications. This could include situations where the benefits of the action outweigh the potential risks, or where the risks are accepted as part of the process of providing care.

For example, a patient with a life-threatening illness may choose to undergo a risky surgical procedure because the potential benefits (such as improved quality of life or increased longevity) outweigh the risks (such as complications from the surgery or anesthesia). Similarly, a healthcare provider may prescribe a medication with known side effects because the benefits of the medication for treating the patient's condition are deemed to be greater than the potential risks.

Risk-taking can also refer to behaviors that increase the likelihood of negative health outcomes, such as engaging in high-risk activities like substance abuse or dangerous sexual behavior. In these cases, healthcare providers may work with patients to identify and address the underlying factors contributing to their risky behaviors, such as mental health issues or lack of knowledge about safe practices.

Methadone is a synthetic opioid agonist, often used as a substitute for heroin or other opiates in detoxification programs or as a long-term maintenance drug for opiate addiction. It works by changing how the brain and nervous system respond to pain signals. It also helps to suppress the withdrawal symptoms and cravings associated with opiate dependence.

Methadone is available in various forms, including tablets, oral solutions, and injectable solutions. It's typically prescribed and dispensed under strict medical supervision due to its potential for abuse and dependence.

In a medical context, methadone may also be used to treat moderate to severe pain that cannot be managed with other types of medication. However, its use in this context is more limited due to the risks associated with opioid therapy.

3' Untranslated Regions (3' UTRs) are segments of messenger RNA (mRNA) that do not code for proteins. They are located after the last exon, which contains the coding sequence for a protein, and before the poly-A tail in eukaryotic mRNAs.

The 3' UTR plays several important roles in regulating gene expression, including:

1. Stability of mRNA: The 3' UTR contains sequences that can bind to proteins that either stabilize or destabilize the mRNA, thereby controlling its half-life and abundance.
2. Localization of mRNA: Some 3' UTRs contain sequences that direct the localization of the mRNA to specific cellular compartments, such as the synapse in neurons.
3. Translation efficiency: The 3' UTR can also contain regulatory elements that affect the translation efficiency of the mRNA into protein. For example, microRNAs (miRNAs) can bind to complementary sequences in the 3' UTR and inhibit translation or promote degradation of the mRNA.
4. Alternative polyadenylation: The 3' UTR can also contain multiple alternative polyadenylation sites, which can lead to different lengths of the 3' UTR and affect gene expression.

Overall, the 3' UTR plays a critical role in post-transcriptional regulation of gene expression, and mutations or variations in the 3' UTR can contribute to human diseases.

Viral activation, also known as viral reactivation or virus reactivation, refers to the process in which a latent or dormant virus becomes active and starts to replicate within a host cell. This can occur when the immune system is weakened or compromised, allowing the virus to evade the body's natural defenses and cause disease.

In some cases, viral activation can be triggered by certain environmental factors, such as stress, exposure to UV light, or infection with another virus. Once activated, the virus can cause symptoms similar to those seen during the initial infection, or it may lead to new symptoms depending on the specific virus and the host's immune response.

Examples of viruses that can remain dormant in the body and be reactivated include herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV). It is important to note that not all viruses can be reactivated, and some may remain dormant in the body indefinitely without causing any harm.

Phlebotomy is a medical term that refers to the process of making an incision in a vein, usually in the arm, in order to draw blood. It is also commonly known as venipuncture. This procedure is performed by healthcare professionals for various purposes such as diagnostic testing, blood donation, or therapeutic treatments like phlebotomy for patients with hemochromatosis (a condition where the body absorbs too much iron from food).

The person who performs this procedure is called a phlebotomist. They must be trained in the proper techniques to ensure that the process is safe and relatively pain-free for the patient, and that the blood sample is suitable for laboratory testing.

Torque teno virus (TTV) is a single-stranded DNA virus that belongs to the family Anelloviridae. It was first identified in 1997 and has since been found to be present in the majority of human populations worldwide. The virus is classified into several genotypes and subtypes, with TTV being the prototype member of the genus Alphainellovirus.

TTV is a small virus, measuring only about 30-40 nanometers in diameter. It has a circular genome that ranges in size from 2.8 to 3.9 kilobases and encodes for several non-structural proteins involved in viral replication. The virus does not appear to cause any specific disease symptoms, but it has been associated with various clinical conditions such as liver disease, respiratory tract infections, and cancer.

TTV is primarily transmitted through the fecal-oral route, although other modes of transmission have also been suggested, including saliva, blood, and vertical transmission from mother to child during pregnancy or delivery. The virus has been detected in various body fluids, tissues, and organs, including blood, stool, respiratory secretions, and the liver.

The clinical significance of TTV infection remains unclear, as it is frequently found in both healthy individuals and those with various diseases. However, some studies have suggested that TTV viral load or genotype may be associated with certain clinical conditions, such as liver disease, transplant rejection, and cancer. Further research is needed to better understand the role of TTV in human health and disease.

A newborn infant is a baby who is within the first 28 days of life. This period is also referred to as the neonatal period. Newborns require specialized care and attention due to their immature bodily systems and increased vulnerability to various health issues. They are closely monitored for signs of well-being, growth, and development during this critical time.

"Age distribution" is a term used to describe the number of individuals within a population or sample that fall into different age categories. It is often presented in the form of a graph, table, or chart, and can provide important information about the demographic structure of a population.

The age distribution of a population can be influenced by a variety of factors, including birth rates, mortality rates, migration patterns, and aging. Public health officials and researchers use age distribution data to inform policies and programs related to healthcare, social services, and other areas that affect the well-being of populations.

For example, an age distribution graph might show a larger number of individuals in the younger age categories, indicating a population with a high birth rate. Alternatively, it might show a larger number of individuals in the older age categories, indicating a population with a high life expectancy or an aging population. Understanding the age distribution of a population can help policymakers plan for future needs and allocate resources more effectively.

Blood safety is a term used to describe the measures taken to ensure that blood and blood products are free from infectious agents and are safe for transfusion. This includes rigorous screening processes for donors, testing of donated blood for various infectious diseases such as HIV, hepatitis B and C, syphilis, and West Nile virus, and proper handling, storage, and distribution of blood products. Additionally, strict quality control measures are in place to ensure the accuracy and reliability of test results. The goal of blood safety is to protect recipients from transfusion-transmitted infections while ensuring an adequate supply of safe blood for those in need.

Molecular models are three-dimensional representations of molecular structures that are used in the field of molecular biology and chemistry to visualize and understand the spatial arrangement of atoms and bonds within a molecule. These models can be physical or computer-generated and allow researchers to study the shape, size, and behavior of molecules, which is crucial for understanding their function and interactions with other molecules.

Physical molecular models are often made up of balls (representing atoms) connected by rods or sticks (representing bonds). These models can be constructed manually using materials such as plastic or wooden balls and rods, or they can be created using 3D printing technology.

Computer-generated molecular models, on the other hand, are created using specialized software that allows researchers to visualize and manipulate molecular structures in three dimensions. These models can be used to simulate molecular interactions, predict molecular behavior, and design new drugs or chemicals with specific properties. Overall, molecular models play a critical role in advancing our understanding of molecular structures and their functions.

A Branched DNA (bDNA) Signal Amplification Assay is a medical diagnostic technique used to detect and quantify specific nucleic acid sequences, such as viral RNA or DNA. This method utilizes a series of hybridization and amplification steps to produce a measurable signal that is proportional to the amount of target nucleic acid present in a sample.

The bDNA assay involves several key components:

1. Probe Set: A set of synthetic oligonucleotides (DNA or RNA) designed to selectively bind to the target nucleic acid sequence. These probes are modified with unique sequences, called "branches," that serve as attachment points for additional probes in subsequent steps.
2. Amplifier Probes: A series of branched DNA molecules that hybridize to the probe set and contain multiple reporter molecules (e.g., enzymes or fluorophores) at their termini. These amplifier probes enhance the sensitivity of the assay by increasing the number of detectable signal molecules per target nucleic acid sequence.
3. Labeling Probes: Oligonucleotides that hybridize to the amplifier probes and contain a detectable label, such as a chemiluminescent or fluorescent moiety. These probes generate the measurable signal during the final step of the assay.
4. Signal Detection: The detection and quantification of the labeled probes can be performed using various methods, depending on the type of label used. For example, chemiluminescence or fluorescence can be measured using a luminometer or a fluorimeter, respectively.

The bDNA Signal Amplification Assay offers several advantages over other nucleic acid detection techniques, including its ability to detect low levels of target nucleic acids and its compatibility with a wide range of sample types (e.g., serum, plasma, tissue). However, it is generally more complex and time-consuming than alternative methods like PCR or real-time qPCR.

This technique has been widely used for the detection and quantification of various viruses, such as HIV, HCV, and HPV, in clinical settings to monitor viral loads and assess treatment efficacy.

Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum. It progresses in several stages if left untreated, with symptoms varying in each stage. The primary stage involves the appearance of a single, painless sore or multiple sores at the site where the bacteria entered the body, often on the genitals or around the mouth. During the secondary stage, individuals may experience rashes, fever, swollen lymph nodes, and other flu-like symptoms. In later stages, syphilis can lead to severe complications affecting the heart, brain, and other organs, known as tertiary syphilis. Neurosyphilis is a form of tertiary syphilis that affects the nervous system, causing various neurological problems. Congenital syphilis occurs when a pregnant woman with syphilis transmits the infection to her unborn child, which can result in serious birth defects and health issues for the infant. Early detection and appropriate antibiotic treatment can cure syphilis and prevent further complications.

Trans-activators are proteins that increase the transcriptional activity of a gene or a set of genes. They do this by binding to specific DNA sequences and interacting with the transcription machinery, thereby enhancing the recruitment and assembly of the complexes needed for transcription. In some cases, trans-activators can also modulate the chromatin structure to make the template more accessible to the transcription machinery.

In the context of HIV (Human Immunodeficiency Virus) infection, the term "trans-activator" is often used specifically to refer to the Tat protein. The Tat protein is a viral regulatory protein that plays a critical role in the replication of HIV by activating the transcription of the viral genome. It does this by binding to a specific RNA structure called the Trans-Activation Response Element (TAR) located at the 5' end of all nascent HIV transcripts, and recruiting cellular cofactors that enhance the processivity and efficiency of RNA polymerase II, leading to increased viral gene expression.

Tertiary protein structure refers to the three-dimensional arrangement of all the elements (polypeptide chains) of a single protein molecule. It is the highest level of structural organization and results from interactions between various side chains (R groups) of the amino acids that make up the protein. These interactions, which include hydrogen bonds, ionic bonds, van der Waals forces, and disulfide bridges, give the protein its unique shape and stability, which in turn determines its function. The tertiary structure of a protein can be stabilized by various factors such as temperature, pH, and the presence of certain ions. Any changes in these factors can lead to denaturation, where the protein loses its tertiary structure and thus its function.

A genetic vector is a vehicle, often a plasmid or a virus, that is used to introduce foreign DNA into a host cell as part of genetic engineering or gene therapy techniques. The vector contains the desired gene or genes, along with regulatory elements such as promoters and enhancers, which are needed for the expression of the gene in the target cells.

The choice of vector depends on several factors, including the size of the DNA to be inserted, the type of cell to be targeted, and the efficiency of uptake and expression required. Commonly used vectors include plasmids, adenoviruses, retroviruses, and lentiviruses.

Plasmids are small circular DNA molecules that can replicate independently in bacteria. They are often used as cloning vectors to amplify and manipulate DNA fragments. Adenoviruses are double-stranded DNA viruses that infect a wide range of host cells, including human cells. They are commonly used as gene therapy vectors because they can efficiently transfer genes into both dividing and non-dividing cells.

Retroviruses and lentiviruses are RNA viruses that integrate their genetic material into the host cell's genome. This allows for stable expression of the transgene over time. Lentiviruses, a subclass of retroviruses, have the advantage of being able to infect non-dividing cells, making them useful for gene therapy applications in post-mitotic tissues such as neurons and muscle cells.

Overall, genetic vectors play a crucial role in modern molecular biology and medicine, enabling researchers to study gene function, develop new therapies, and modify organisms for various purposes.

A dose-response relationship in the context of drugs refers to the changes in the effects or symptoms that occur as the dose of a drug is increased or decreased. Generally, as the dose of a drug is increased, the severity or intensity of its effects also increases. Conversely, as the dose is decreased, the effects of the drug become less severe or may disappear altogether.

The dose-response relationship is an important concept in pharmacology and toxicology because it helps to establish the safe and effective dosage range for a drug. By understanding how changes in the dose of a drug affect its therapeutic and adverse effects, healthcare providers can optimize treatment plans for their patients while minimizing the risk of harm.

The dose-response relationship is typically depicted as a curve that shows the relationship between the dose of a drug and its effect. The shape of the curve may vary depending on the drug and the specific effect being measured. Some drugs may have a steep dose-response curve, meaning that small changes in the dose can result in large differences in the effect. Other drugs may have a more gradual dose-response curve, where larger changes in the dose are needed to produce significant effects.

In addition to helping establish safe and effective dosages, the dose-response relationship is also used to evaluate the potential therapeutic benefits and risks of new drugs during clinical trials. By systematically testing different doses of a drug in controlled studies, researchers can identify the optimal dosage range for the drug and assess its safety and efficacy.

'Virus release' in a medical context typically refers to the point at which a virus that has infected a host cell causes that cell to rupture or disintegrate, releasing new viruses into the surrounding tissue or bodily fluids. This is a key step in the replication cycle of many viruses and can lead to the spread of infection throughout the body.

The process of virus release often follows a phase of viral replication inside the host cell, where the virus uses the cell's machinery to produce multiple copies of its genetic material and proteins. Once enough new viruses have been produced, they can cause the host cell membrane to break down, allowing the viruses to exit and infect other cells.

It is important to note that not all viruses follow this pattern of replication, and some may use alternative mechanisms such as budding or exocytosis to release new viruses from infected cells.

I'm sorry for any confusion, but "India" is not a medical term or concept. It is a country in South Asia, the second-most populous country in the world, known for its rich history, diverse culture, and numerous contributions to various fields including medicine. If you have any questions related to medical topics, I would be happy to help answer them!

Viral hepatitis is caused by five different viruses (hepatitis A, B, C, D, and E). Hepatitis A and hepatitis E behave similarly ... In the Mediterranean, hepatitis D is predominant among hepatitis B virus co-infected people. Similar to Hepatitis A, hepatitis ... and are self-limiting illnesses that do not lead to chronic hepatitis. Hepatitis B, hepatitis C, and hepatitis D are ... Hepatitis D is a defective virus that requires hepatitis B to replicate and is only found with hepatitis B co-infection. In ...
... is hepatitis (inflammation of the liver) due to excessive intake of alcohol. Patients typically have a ... Alcoholic hepatitis is distinct from cirrhosis caused by long-term alcohol consumption. Alcoholic hepatitis can occur in ... A liver biopsy is not required for the diagnosis, however it can help confirm alcoholic hepatitis as the cause of the hepatitis ... Alcoholic hepatitis occurs in approximately 1/3 of chronic alcohol drinkers. 10-20% of patients with alcoholic hepatitis ...
... is a type of viral hepatitis caused by the hepatitis delta virus (HDV). HDV is one of five known hepatitis viruses ... Vaccination against hepatitis B protects against hepatitis D viral infection as hepatitis D requires hepatitis B viral ... In combination with hepatitis B virus, hepatitis D has the highest fatality rate of all the hepatitis infections, at 20%. A ... November 2009). "Hepatitis B virus and hepatitis delta virus genotypes in outbreaks of fulminant hepatitis (Labrea black fever ...
"Source details: Hepatitis Monthly". Scopus Preview. Elsevier. Retrieved 2019-12-05. "Hepatitis Monthly". 2018 Journal Citation ... Hepatitis Monthly is a monthly peer-reviewed open access medical journal published by Brieflands Publishing, formerly known as ... "Hepatitis Monthly". MIAR: Information Matrix for the Analysis of Journals. University of Barcelona. Retrieved 2019-12-05. " ...
... it is also imperative to be able to exclude the possibility of acute viral hepatitis. Ischemic hepatitis is related to another ... can also cause ischemic hepatitis.[medical citation needed] People who develop ischemic hepatitis may have weakness, fatigue, ... Ischemic hepatitis, also known as shock liver, is a condition defined as an acute liver injury caused by insufficient blood ... Ischemic hepatitis can be caused by a number of reasons (that lead to low blood pressure) including: Abnormal heart rhythm ...
Non-A-E hepatitis, also known as hepatitis X, is an infectious disease of the liver referring to a case of viral hepatitis that ... The specific cause of non-A-E hepatitis is unknown. It is considered a rare disorder. "Non-A-E hepatitis". Genetic and Rare ... "Acute Non-A-E Hepatitis in the United States and the Role of Hepatitis G Virus Infection". N Engl J Med. 336 (11): 741-746. doi ... "TTV infection in patients with acute hepatitis of defined aetiology and in acute non-A-E hepatitis". Journal of Hepatology. 32 ...
The causes of neonatal hepatitis are many. Viruses that have been identified include cytomegalovirus, rubella virus, hepatitis ... Neonatal hepatitis refers to many forms of liver dysfunction that affects fetuses and neonates. It is most often caused by ... The infant with neonatal hepatitis usually has jaundice that appears at one to two months of age, is not gaining weight and ... Jaundice that is caused by neonatal hepatitis is not the same as physiologic neonatal jaundice. In contrast with physiologic ...
World Hepatitis Day, observed 28 July, aims to raise global awareness of hepatitis B and hepatitis C and encourage prevention, ... Hepatitis B was originally known as "serum hepatitis". Acute infection with hepatitis B virus is associated with acute viral ... when combined with hepatitis B immunoglobulin and the hepatitis B vaccine, especially for pregnant women with high hepatitis B ... hepatitis B immunoglobulin alone, or the combination of vaccine plus hepatitis B immunoglobulin, all prevent hepatitis B ...
... is inflammation of the liver caused by infection with the hepatitis E virus (HEV); it is a type of viral hepatitis ... Hepatitis E has mainly a fecal-oral transmission route that is similar to hepatitis A, although the viruses are unrelated. In ... Like hepatitis A, hepatitis E usually follows an acute and self-limiting course of illness (the condition is temporary and the ... In 2017, hepatitis E was estimated to affect more than 19 million people. Those most commonly at risk of HEV are men aged 15 to ...
... ". Discogs. Retrieved 2018-01-23. "NOFX - Hepatitis Bathtub - Discography - FatWreckWiki". www.fatwreckwiki. ... Hepatitis Bathtub is an EP by NOFX released on December 23, 2016 through Fat Wreck Chords. The EP was released as a four-song 7 ... The Hepatitis Bathtub and Other Stories was eventually released in April 2016. "Too Mixed Up" "Nothing But a Nightmare" ( ... It was also available as a deluxe package in limited edition color vinyl with a hardcover copy of NOFX's book The Hepatitis ...
World Hepatitis Day occurs each year on July 28 to bring awareness to viral hepatitis. Early symptoms of Hepatitis A infection ... Hepatitis A is an infectious disease of the liver caused by Hepatovirus A (HAV); it is a type of viral hepatitis. Many cases ... It is one of five known hepatitis viruses: A, B, C, D, and E. The hepatitis A vaccine is effective for prevention.[needs update ... 2019 United States hepatitis A outbreak Matheny, SC; Kingery, JE (1 December 2012). "Hepatitis A." Am Fam Physician. 86 (11): ...
Hepatitis D is caused by the hepatitis D virus (HDV), or hepatitis delta virus; it belongs to the genus Deltavirus. HDV is ... Patients with hepatitis C are susceptible to severe hepatitis if they contract either hepatitis A or B, so all persons with ... Hepatitis E is caused by the Hepatitis E virus (HEV), from the family Hepeviridae. It produces symptoms similar to hepatitis A ... Hepatitis A and hepatitis B can be prevented by vaccination. Effective treatments for hepatitis C are available but costly. In ...
... is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of ... It is one of five known hepatitis viruses: A, B, C, D, and E. Diagnosis is by blood testing to look for either antibodies to ... There is no vaccine against hepatitis C. Prevention includes harm reduction efforts among people who inject drugs, testing ... viral hepatitis. During the initial infection period, people often have mild or no symptoms. Early symptoms can include fever, ...
Other causes of hepatitis: Viral hepatitis - it is necessary to distinguish autoimmune hepatitis from acute hepatitis caused by ... Autoimmune hepatitis, formerly known as lupoid hepatitis, plasma cell hepatitis, or autoimmune chronic active hepatitis, is a ... doi:10.1002/hep.23584. PMID 20513004. S2CID 30356212. Than NN, Jeffery HC, Oo YH (2016). "Autoimmune Hepatitis: Progress from ... Autoimmune hepatitis was previously called "lupoid" hepatitis due to people having an associated autoimmune disease like system ...
Co-infection of hepatitis B and various other viruses can also occur. hepatitis C, hepatitis D (a satellite virus of hepatitis ... Hepatitis B virus causes the disease hepatitis B. Hepatitis is considered to be the leading cause of liver cancer worldwide ( ... "Hepatitis B Foundation: Hepatitis C and Hepatitis B Coinfection". www.hepb.org. Retrieved 2 December 2022. Thio, Chloe L. (May ... Rates of hepatitis B infection are equal across male and females. Hepatitis B virus is more prominently found in US citizens of ...
"Turkey Viral Hepatitis - WikiVet English". Retrieved 10 July 2011. v t e (Articles lacking in-text citations from October 2011 ... The aetiological agent of turkey viral hepatitis is a virus from the Picornaviridae family. The disease is restricted to ...
... is May 19 in the United States. "Hepatitis Awareness Month and Hepatitis Testing Day - Division of Viral ... v t e (Health awareness days, Hepatitis, May observances, Observances in the United States, All stub articles, Health stubs). ... Hepatitis - CDC". www.cdc.gov. Retrieved 24 May 2017. ...
The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma, abbreviated ... doi:10.1002/hep.20819. PMID 16149085. S2CID 21393716. Yu ML, Chuang WL (2009). "Treatment of chronic hepatitis C in Asia: when ... Wikimedia Commons has media related to Hepatitis C virus. Wikispecies has information related to Hepatitis C virus. Academic ... Unlike hepatitis A and B, there is currently no vaccine to prevent hepatitis C infection. The study of HCV has been hampered by ...
The Hepatitis B Foundation (HBF) is an American nonprofit organization dedicated to finding a cure for hepatitis B and ... To meet the unmet needs of those living with chronic hepatitis B, they created the Hepatitis B Foundation with the help of the ... The Hepatitis B Foundation is a nonprofit organization that provides resources and information about hepatitis B, engages in ... "Hepatitis B group launches campaign". The Intelligencer. February 14, 2011. The Hepatitis B Foundation which is headquartered ...
... (WHV) is a species of the genus Orthohepadnavirus. It was first discovered in 1977 in a captive ... Tennant, W. C. (1999). "The Woodchuck Model of Hepatitis B Virus Infection". Handbook of animal models of infection: ... Tyler, Gail V.; Summers, Jesse W.; Synder, Robert L. (1981). "Woodchuck Hepatitis Virus in Natural Woodchuck Populations". ... this has led to the use of WHV in woodchucks as a model for human Hepatitis B virus infections. ...
... is a rare medical condition characterised by granulomas in the liver, recurrent fever, ... The condition is not a true hepatitis, and some experts believe it is a variant of sarcoidosis. Herrine, Steven K. (November ...
Hepatitis B vaccination, hepatitis B immunoglobulin, and the combination of hepatitis B vaccine plus hepatitis B immunoglobulin ... is a vaccine against hepatitis A and hepatitis B. Pediarix is a vaccine against diphtheria, tetanus, pertussis, hepatitis B, ... Hepatitis B vaccine is a vaccine that prevents hepatitis B. The first dose is recommended within 24 hours of birth with either ... "FAQs about Hepatitis B Vaccine (Hep B) and Multiple Sclerosis". U.S. Centers for Disease Control and Prevention (CDC). 9 ...
... (ICH) is an acute liver infection in dogs caused by Canine mastadenovirus A, formerly called Canine ... Diagnosis is made by recognizing the combination of symptoms and abnormal blood tests that occur in infectious canine hepatitis ... ISBN 978-0-7216-6795-9. "Infectious Canine Hepatitis: Introduction". The Merck Veterinary Manual. 2006. Retrieved 2007-01-28. ... infectious canine hepatitis virus, and distemper virus experimental challenges". Vet Ther. 5 (3): 173-86. PMID 15578450. Canine ...
"World Hepatitis Day 2016" (PDF). World Hepatitis Alliance. 2016. "World Hepatitis Summit". World Hepatitis Summit. 2017. "World ... all of whom must be chronic viral hepatitis patients: someone who has or has had chronic hepatitis B or chronic hepatitis C ... the first World Hepatitis Summit was convened by the WHO and World Hepatitis Alliance with the aim of uniting World Hepatitis ... NOhep was created by the World Hepatitis Alliance with the aim of becoming a global movement to eliminate viral hepatitis. WHA ...
Duck hepatitis is an acute and fatal disease in ducklings caused by the Avihepatovirus DHV-1 and DHV-3. It causes opisthotonus ... and hepatitis. DHV-1 is found worldwide. It causes disease in young ducklings, usually ...
Hepatitis A and B vaccine is a vaccine against hepatitis A and hepatitis B. Hepatitis A and typhoid vaccine is a vaccine ... Hepatitis A vaccine is a vaccine that prevents hepatitis A. It is effective in around 95% of cases and lasts for at least ... It is a freeze-dried live attenuated hepatitis A vaccine. Hepatitis A virus H2 strain is produced in human diploid cells. A ... A few formulations combine hepatitis A with either hepatitis B or typhoid vaccine. Soreness or redness where the shot is given ...
... is a disease of large animals, especially sheep, caused by Clostridium novyi infection. The ... Stampfi, Henry (March 2014). "Infectious Necrotic Hepatitis". The Merck Veterinary Manual. Merck Sharp & Dohme Corp. Retrieved ... Wikimedia Commons has media related to infectious necrotic hepatitis. (Articles with short description, Short description ...
IFN-free Regimens HCV Comorbidities Clinical Challenges in Hepatitis C Hepatitis B Hepatitis D and E Hepatocellular carcinoma ... Frankfurt, Germany.: Journal of Viral Hepatitis: Vol 19, No s3". Journal of Viral Hepatitis. 19. 2012. doi:10.1111/jvh.2012.19. ... "Abstracts for the Viral Hepatitis Congress 2013, 26-28 September 2013, Frankfurt, Germany: Journal of Viral Hepatitis: Vol 20, ... No s3". Journal of Viral Hepatitis. 20. 2013. doi:10.1111/jvh.2013.20.issue-s3. v t e (Academic conferences, Viral hepatitis, ...
A hepatitis C vaccine, a vaccine capable of protecting against the hepatitis C virus (HCV), is not yet available. Although ... "The hepatitis C virus". WHO. Archived from the original on 4 October 2013. Retrieved 1 October 2013. Torresi J (7 November 2017 ... "Hepatitis C Questions and Answers for the Public". Centers for Disease Control and Prevention. 10 September 2019. Retrieved 20 ... Strickland GT, El-Kamary SS, Klenerman P, Nicosia A (June 2008). "Hepatitis C vaccine: supply and demand". The Lancet. ...
Hepatitis. 2019: Invest in eliminating hepatitis. 2020: Hepatitis Free Future 2021: Hepatitis can't wait 2022: Bringing ... World Health Organization World Hepatitis Day, World Hepatitis Alliance World Hepatitis Day, Hepatitis Types, Causes and ... World Hepatitis Alliance, World Hepatitis Day Wrap-Up Report 2012. "World Hepatitis Day 2015 to focus on prevention". World ... 2014: Hepatitis: Think Again 2015: Prevention of viral Hepatitis. Act now. 2016: Know Hepatitis-Act now. 2017: Eliminate ...
... an infection that only occurs with hepatitis B and causes liver inflammation and damage. Hepatitis D can be acute or chronic. ... How do hepatitis D and hepatitis B infections occur together?. Hepatitis D and hepatitis B infections may occur together as a ... What causes hepatitis D?. The hepatitis D virus causes hepatitis D. The hepatitis D virus spreads through contact with an ... No vaccine for hepatitis D is currently available. The hepatitis B vaccine can prevent hepatitis D by preventing hepatitis B. ...
Find a hepatitis C treatment provider near you today. ... Hepatitis C is a vaccine-preventable liver infection caused by ... Hepatitis C is a liver infection caused by the hepatitis C virus (HCV). Hepatitis C is spread through contact with blood from ... For some people, hepatitis C is a short-term illness, but for more than half of people who become infected with the hepatitis C ... Getting tested for hepatitis C is important, because treatments can cure most people with hepatitis C in 8 to 12 weeks. ...
In the United States, hepatitis C is a nationally notifiable disease. Hepatitis C testing is required for diagnosis. Testing is ... and hepatitis C screening for all pregnant people during each pregnancy. See information on how to obtain hepatitis C ... Hepatitis C virus (HCV) is a spherical, enveloped, positive-strand RNA virus. Seven distinct HCV genotypes and 67 subtypes have ... CDC recommendations for hepatitis C screening among adults-United States, 2020. MMWR Morb Mortal Recomm Rep. 2020;69(2):1-17. ...
Hepatitis A[majr:noexp] AND humans[mh] AND english[la] AND last 1 Year [edat] NOT (letter[pt] OR case reports[pt] OR ... Hepatitis D (DELTA). Rizzetto M. Rizzetto M. New Microbiol. 2022 Jul;45(3):149-154. New Microbiol. 2022. PMID: 35920869 Free ... Viral hepatitis: Past, present, and future. Odenwald MA, Paul S. Odenwald MA, et al. World J Gastroenterol. 2022 Apr 14;28(14): ... Viral Hepatitis, Cholesterol Metabolism, and Cholesterol-Lowering Natural Compounds. Liou JW, Mani H, Yen JH. Liou JW, et al. ...
Hepatitis B virus is a contagious liver infection spread from person-to-person via blood or body fluids. Who is at risk for HBV ... Prevention Tips for Hepatitis B (Hepatitis B Foundation) * Safety Information for Hepatitis B Vaccines (Centers for Disease ... What is hepatitis B?. Hepatitis B is a type of viral hepatitis. It can cause an acute (short-term) or chronic (long-term) ... What causes hepatitis B?. Hepatitis B is caused by the hepatitis B virus. The virus spreads through contact with blood, semen, ...
... hepatitis means inflammation of the liver. There are five main hepatitis viruses (A, B, C, D or E). Learn about the different ... Hepatitis B, hepatitis C, and hepatitis D spread through contact with the blood of someone who has the disease. Hepatitis B and ... How is viral hepatitis spread?. Hepatitis A and hepatitis E usually spread through contact with food or water that was ... What causes hepatitis?. There are different types of hepatitis, with different causes:. *Viral hepatitis is the most common ...
... can present in very serious forms in some patients. How do clinicians go about diagnosing and treating this ... Box 2. Novel histological grading systems for alcoholic hepatitis. • Mookerjee et al. 34 *. Ballooning and inflammatory score ... Table 2. Summary of therapeutic trials in alcoholic hepatitis; 1992-2012. Study (year). Country. Therapy studied. Study design ... Alcoholic hepatitis (AH) is an inflammatory liver injury occurring after years of alcohol excess. Most patients present acutely ...
Chronic hepatitis B and C claim almost 1.34 million lives each year globally. In the South-East Asia Region, viral hepatitis ... To tackle viral hepatitis, Member States of the WHO South-East Asia Region have endorsed the Global Health Sector Strategy on ... With 49 million people estimated to be chronically infected with hepatitis B and C, the number of deaths will only increase if ... 2)‎ Focus on gaps in the hepatitis B birth dose coverage to ensure at least 95% coverage by 2020.(‎3)‎ Ensure that injection ...
Hepatitis B PSAs, fact sheets, posters, flyers, risk assessment, vaccine cards, quizzes, buttons, and information for pregnant ... Hepatitis B is treatable, but the first step is to get tested.. Protect your family by getting tested for hepatitis B today. # ... Hepatitis B is a serious disease.. Protect your family by getting tested and vaccinated for hepatitis B today. Visit the CDCs ... This 2-page fact sheet is for pregnant women who have Hepatitis B and explains the importance of the Hepatitis B vaccine in ...
Read full-text medical journal articles from Medscapes Hepatitis B News. ... ACG Hep C Treatment Prognosis Continues to Amaze Advances in hepatitis C treatments have more patients with complex disease ... Immunizing Infants Against Hepatitis B Tied to Lower Risk of Liver Cancer Immunizing infants against hepatitis B virus (HBV) ... AASLD Novel Treatment Could Lead to Functional Control of Hep B Nucleic acid polymers block the release of the hepatitis B ...
Alcoholic hepatitis is a syndrome of progressive inflammatory liver injury associated with long-term heavy intake of ethanol. ... Alcoholic hepatitis and concomitant hepatitis C virus infection. World J Gastroenterol. 2014 Sep 14. 20(34):11929-34. [QxMD ... encoded search term (Alcoholic Hepatitis) and Alcoholic Hepatitis What to Read Next on Medscape ... Alcoholic Hepatitis Medication. Updated: Sep 19, 2019 * Author: Douglas M Heuman, MD, FACP, FACG, AGAF; Chief Editor: BS Anand ...
Programs to prevent and control HIV, other STDs, viral hepatitis, TB. *Promoting school-based health and disease prevention ... Viral Hepatitis, STD, and TB Prevention (NCHHSTP). ... Source: National Center for HIV, Viral Hepatitis, STD, and TB ...
There are at least 5 hepatitis viruses.. Hepatitis A is contracted when a child eats food or drinks water that is contaminated ... Hepatitis symptoms tend to be similar from one virus type to another. Many of these symptoms are flu like, such as fever, ... A hepatitis infection is also associated with jaundice, a yellow discoloration of the skin and a yellowish color to the whites ... Hepatitis means "inflammation of the liver." This inflammation can be caused by a wide variety of toxins, drugs, and metabolic ...
... Prevention. How great is the risk for hepatitis B?. You may be at risk for hepatitis B if you:. How is hepatitis B ... If you had hepatitis A, it is still possible to get hepatitis B. If you had hepatitis C, another form of hepatitis that can be ... Can hepatitis B be spread by food?. Unlike hepatitis A, another form of hepatitis, hepatitis B is not spread through food or ... Can hepatitis B be spread by food?. What is the hepatitis B carrier state?. What are the symptoms of hepatitis B?. How serious ...
Researchers determined the structure of a protein that allows the hepatitis C virus to gain entry into cells. The finding may ... Hepatitis Risk Assessment (CDC). References: Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2. ... Hepatitis C is an infectious disease caused by a virus. The hepatitis C virus (HCV) attacks the liver, leading to inflammation ... HCV is not related to hepatitis viruses A, B, D, and E. While vaccines are available for hepatitis A and B, currently no ...
LBXHA - Hepatitis A antibody. Variable Name: LBXHA SAS Label: Hepatitis A antibody. English Text: Hepatitis A antibody. Target ... New immunization strategies have been developed to eliminate the spread of the hepatitis B virus (HBV) and the hepatitis A ... Reported results for all assays meet the Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and ... Hepatitis A (HEPA_H) Data File: HEPA_H.xpt First Published: October 2015. Last Revised: NA ...
Chronic hepatitis B and C claim almost 1.34 million lives each year globally. In the South-East Asia Region, viral hepatitis ... To tackle viral hepatitis, Member States of the WHO South-East Asia Region have endorsed the Global Health Sector Strategy on ... With 49 million people estimated to be chronically infected with hepatitis B and C, the number of deaths will only increase if ... 2)‎ Focus on gaps in the hepatitis B birth dose coverage to ensure at least 95% coverage by 2020.(‎3)‎ Ensure that injection ...
Hepatitis B surface antigen is absent in a preneoplastic focus from an HBV transgenic mouse. Immunohistochemistry stain ... Hepatitis B surface antigen in hepatocytes of an HBV transgenic mouse. Immunohistochemistry stain counterstained with ...
Hepatitis B, C, and D are responsible for more than a million deaths a year worldwide. ... Hepatitis. Hepatitis is an inflammation of the liver. Viruses are the most common cause of hepatitis, but the condition can ... Hepatitis C is a blood-borne virus that is largely spread by sharing needles or other drug injection equipment. Hepatitis D, ... Why Is the Study of Hepatitis a Priority for NIAID?. Hepatitis B, C, and D afflict more than half a billion people worldwide ...
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Hepatitis A virus has a relatively long incubation period (15 to 50 days). HAVRIX may not prevent hepatitis A infection in ... The hepatitis A virus belongs to the picornavirus family. It is 1 of several hepatitis viruses that cause systemic disease with ... HEPATITIS A VIRUS STRAIN HM175 ANTIGEN (FORMALDEHYDE INACTIVATED) (UNII: 5BFC8LZ6LQ) (HEPATITIS A VIRUS STRAIN HM175 ANTIGEN ( ... The incubation period for hepatitis A averages 28 days (range: 15 to 50 days).1 The course of hepatitis A infection is ...
HEPATITIS C RECOVERY RESEARCH NETWORK Release Date: July 13, 2000 NOTICE: AI-00-006 RFP AVAILABLE: RFP NIH-NIAID-DMID-01-16 AI- ... recovery from hepatitis C virus infection and disease. The HC RRN will carry out a scientific plan to: delineate the factors ...
New WHO data reveal that an estimated 325 million people worldwide are living with chronic hepatitis B virus (HBV) or hepatitis ... 60 million with hepatitis B and 10 million with hepatitis C). Hepatitis B infection is preventable, treatable and hepatitis C ... Hepatitis D is less common and occurs only in association with hepatitis B. The other viruses (namely hepatitis A and E) are ... Hepatitis B. Laboratory diagnosis of hepatitis B infection focuses on the detection of the various hepatitis B antigens ( ...
What causes hepatitis isnt always known. But certain viruses are the most common culprit. ... Learn more about viral hepatitis, autoimmune hepatitis, and NIHs research on hepatitis. ... There are five known viruses that cause the condition: hepatitis A, B, C, D, and E. Hepatitis A and E are usually spread ... Hepatitis has been in the news a lot lately. New cases have been showing up in children around the world. Doctors arent sure ...
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Hepatitis C: Virus and Infection
Alcoholic hepatitis is a serious form of alcohol-associated liver disease, and people with it have high levels of the bacterium ... A specific strain of a common bacteria found in most people with alcoholic hepatitis correlates with greater liver disease ... "Alcoholic hepatitis has a mortality rate of more than 50% within the first 60 days of diagnosis in severe cases and is a ... Alcoholic hepatitis is a serious form of alcohol-associated liver disease, and people with it have high levels of the bacterium ...
  • Hepatitis can be an acute (short-term) infection or a chronic (long-term) infection. (medlineplus.gov)
  • The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. (medscape.com)
  • Hepatitis C virus infection. (medscape.com)
  • Current and future therapies for hepatitis C virus infection. (medscape.com)
  • Increases in acute hepatitis C virus infection related to a growing opioid epidemic and associated injection drug use, United States, 2004 to 2014. (medscape.com)
  • Among immunosuppressed people, particularly solid organ allograft recipients infected with HEV-3, hepatitis E can progress to chronic infection. (cdc.gov)
  • Hepatitis B virus infection can lead to severe illness, liver damage, and in some cases, death. (cdc.gov)
  • Live in the same house with someone who has lifelong hepatitis B virus infection. (cdc.gov)
  • Hepatitis B virus is found in the blood and body fluids of persons with hepatitis B. Contact with even small amounts of infected blood can cause infection. (cdc.gov)
  • Because these serious problems may not develop until many years after a person becomes infected with hepatitis B virus, those who have a lifelong infection should be evaluated periodically by a medical care provider. (cdc.gov)
  • Recommendations have also been developed for the prevention and control of the hepatitis C virus (HCV) infection. (cdc.gov)
  • NHANES testing for markers of infection with hepatitis viruses will be used to determine secular trends in infection rates across most age and racial/ethnic groups, and will provide a national picture of the epidemiologic determinants of these infections. (cdc.gov)
  • Viral hepatitis is a group of viruses (hepatitis A, B, C, the rarer type D, and E) that can cause both acute and chronic infection and inflammation of the liver. (who.int)
  • A vaccine to prevent hepatitis E virus infection has been developed and is licensed in China, but is not yet available elsewhere. (who.int)
  • The acute form of hepatitis, generally caused by viral infection, is characterized by constitutional symptoms that are typically self-limiting. (wikipedia.org)
  • The complication more frequently occurs in instances of hepatitis B and D co-infection at a rate of 2-20% and in pregnant women with hepatitis E at rate of 15-20% of cases. (wikipedia.org)
  • Toy M, Hutton D, Harris AM, Nelson N, Salomon JA, So S. Cost-Effectiveness of 1-Time Universal Screening for Chronic Hepatitis B Infection in Adults in the United States .Clin Infect Dis. (cdc.gov)
  • Hepatitis B virus (HBV) infection in a pregnant person poses a serious risk to their infant at birth. (mass.gov)
  • Pregnant persons should be tested for evidence of hepatitis B virus (HBV) infection, specifically hepatitis B surface antigen (HBsAg), during every pregnancy. (mass.gov)
  • All HBsAg positive pregnant persons should be further tested for HBV DNA levels to guide the use of maternal antiviral therapy, and referred for care appropriately using the CDC's Screening and Referral Algorithm for Hepatitis B Virus (HBV) Infection among Pregnant Women (PDF) . (mass.gov)
  • For the latest recommendations for treatment of chronic HBV infection in pregnant persons, see pages 276-277 in the American Association for the Study of Liver Diseases Guidelines for Treatment of Chronic Hepatitis . (mass.gov)
  • PVST consists of both HBsAg and anti-HBs, and it is imperative that both tests be run to be able to determine if the baby is protected against hepatitis B infection. (mass.gov)
  • Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). (kidshealth.org)
  • Children who have hepatitis (heh-puh-TYE-tus) C most often got the infection as newborns from their mothers. (kidshealth.org)
  • Hepatitis C can be a "silent but deadly" infection. (kidshealth.org)
  • What Happens After a Hepatitis C Infection? (kidshealth.org)
  • Individuals with chronic hepatitis B infection are at risk for cirrhosis and liver cancer, even in the absence of cirrhosis. (massgeneral.org)
  • At the Massachusetts General Hospital Hepatitis B Clinic, we offers comprehensive evaluation, diagnosis and treatment plans for patients with all phases of hepatitis B infection . (massgeneral.org)
  • A liver biopsy, which may be recommended for people with long-term hepatitis B infection, particularly if the virus is very active. (massgeneral.org)
  • Hepatitis B infection can exist in a variety of states, and some of them don't need treatment. (massgeneral.org)
  • However, anyone with hepatitis B infection should be monitored regularly for the development of active hepatitis, which should be treated. (massgeneral.org)
  • Treatment of active hepatitis B infection can include either an oral antiviral pill or an injected medication called interferon. (massgeneral.org)
  • The Mass General Liver Center is participating in a nationwide study to help identify how the immune system affects the phases of hepatitis B infection, with the hopes of identifying how the disease progresses, identifying individuals who need treatment and developing better therapy to treat hepatitis B. (massgeneral.org)
  • If your patient has evidence of hepatitis B infection, our Hepatitis B Clinic can help risk stratify your patient and establish a plan for ongoing disease monitoring or treatment with the most up-to-date antiviral therapy. (massgeneral.org)
  • We are also eager to assist in the care of patients with hepatitis B infection or exposure who are pregnant or due to undergo immunosuppressive therapy or chemotherapy, to help determine the need for antiviral treatment or prophylaxis. (massgeneral.org)
  • To refer a patient with suspected or established hepatitis B infection or exposure, please contact the Hepatitis B Clinic at 617-726-3524. (massgeneral.org)
  • Most cases of hepatitis are caused by viral infection. (britannica.com)
  • Hepatitis C is a condition that affects approximately 3.5 million Americans , with as many as half potentially unaware that they have the infection, according to the United States Centers for Disease Control and Prevention (CDC). (medicalnewstoday.com)
  • What should I know about hepatitis E (hep E) viral infection? (medicinenet.com)
  • Hepatitis E is a viral infection , which is caused by the hepatitis E virus that usually comes from dirty water. (medicinenet.com)
  • Hepatitis E viral infection causes symptoms and signs, for example, soreness and swelling of the liver (hepatitis) and yellow eyes ( jaundice ). (medicinenet.com)
  • Hepatitis E viral infection symptoms and signs include yellow eyes and skin, nausea and vomiting , pain in the right side of the abdomen, dark or brown urine, and light-colored stool . (medicinenet.com)
  • What is hepatitis E (hep E) viral infection? (medicinenet.com)
  • About 3.3% of people with hep E infection die. (medicinenet.com)
  • Chronic hepatitis does not go away and is a long-lasting infection of the liver. (medicinenet.com)
  • Patients who were exposed to Hepatitis C as part of these violations and never became acutely ill may be infected, unaware of it and spread the infection to others or be at risk for long term serious infection side effects, researchers say. (eurekalert.org)
  • Hepatitis B infection is transmitted through sexual contact, contact with contaminated blood (for example, through shared needles used for illicit, intravenous drugs), and from mother to child. (medicinenet.com)
  • Hepatitis B is a liver infection caused by the Hepatitis B virus ( HBV ). (medicinenet.com)
  • however, about 5% of people are not able to eliminate the hepatitis B virus and develop chronic infection. (medicinenet.com)
  • Hello, I was diagnosed with Hepatitis B infection (HbsAg positive), but after 3 months HBsAg turned Non-reactive and the viral DNA i. (medhelp.org)
  • Hepatitis E is an enterically transmitted infection that is typically self-limited. (medscape.com)
  • Hepatitis E results from HEV infection and is spread by fecally contaminated water within endemic areas. (medscape.com)
  • Hepatitis A is a highly contagious liver infection caused by the hepatitis A virus. (longbeach.gov)
  • Hepatitis A is a viral infection that specifically targets the liver. (healthline.com)
  • Unlike hepatitis B and hepatitis C , HAV infection does not lead to chronic liver disease and often resolves on its own without causing long-term damage. (healthline.com)
  • In a minority of cases, HEV causes acute and chronic hepatitis, but infection is commonly asymptomatic or unrecognized. (nature.com)
  • Extra-hepatic manifestations of autochthonous hepatitis E infection. (nature.com)
  • Acute hepatitis E infection acquired in California. (nature.com)
  • In Western countries when we hear the word "hepatitis" we tend to think in terms of Hepatitis A, B, or C. However, there are several different strains of the disease, one of them being Hepatitis E. As with all other types of hepatitis, Hepatitis E is caused by infection with a specific virus, in this case Hepatitis E Virus (HEV). (womens-health.co.uk)
  • Specifically, the study analyzed serum samples from 275 Iberian lynxes, and liver and feces samples from 176 others, to test the prevalence and seroprevalence of the Hepatitis E Virus, i.e. the presence of active virus and of antibodies once the infection has passed. (eurekalert.org)
  • The document added three groups at a higher risk for HBV infection: those incarcerated or formerly incarcerated, people with current or past hepatitis C virus infection, and people with current or past sexually transmitted infections and multiple sex partners. (medscape.com)
  • Along with vaccination strategies, universal screening of adults and appropriate testing of persons at increased risk for HBV infection will improve health outcomes, reduce the prevalence of HBV infection in the United States, and advance viral hepatitis elimination goals," the authors write. (medscape.com)
  • Explaining the study, lead author Professor Mala Maini (UCL Division of Infection & Immunity), said: "Chronic hepatitis B virus infection is a major global health problem and the most common cause of liver cancer in the world. (sciencedaily.com)
  • Commenting on the findings, first author Dr Nathalie Schmidt (UCL Division of Infection & Immunity), said: "We have found a highly effective novel target for the treatment of chronic hepatitis B virus infection and liver cancer. (sciencedaily.com)
  • Hepatitis C is a viral infection of the liver. (healthline.com)
  • A hepatitis panel is a blood test used to find markers of hepatitis infection. (healthlinkbc.ca)
  • A positive result may mean that you have hepatitis antibodies from a recent infection. (healthlinkbc.ca)
  • For many, especially children, hepatitis B infection is asympomatic. (health.mil)
  • For some people, including most infected in infancy, hepatitis B can become a long-term, chronic infection. (health.mil)
  • Hepatitis A is a contagious liver disease that results from infection with the Hepatitis A virus. (cabrillo.edu)
  • Understanding your hepatitis B blood test results can be confusing, so you want to be sure about your diagnosis - are you infected with hepatitis B, have you recovered from a hepatitis B infection, or do you have a chronic hepatitis B infection? (hepb.org)
  • A "positive" or "reactive" HBsAg test result means that the person is infected with the hepatitis B virus, which can be an "acute" or a "chronic" infection. (hepb.org)
  • A "positive" or "reactive" HBsAb (or anti-HBs) test result indicates that a person has either successfully responded to the hepatitis B vaccine or has recovered from an acute hepatitis B infection. (hepb.org)
  • This result (along with a negative HbsAg result) means that you are immune to (protected from) a future hepatitis B infection. (hepb.org)
  • There is a very high rates of morbidity and mortality in Egypt due to hepatitis C chronic infection or its complications either cirrhosis or liver cancer. (bartleby.com)
  • More frozen berry products have been recalled due to possible Hepatitis A contamination, with at least five people contracting the infection in the food scare. (theage.com.au)
  • The most common serious liver infection in the world is hepatitis B, with about three-hundred and fifty million people who are chronic carriers of the infection. (disabled-world.com)
  • When evaluating a patient with suspected hepatitis B virus (HBV) infection, also consider the other viral hepatitides and etiologies that can lead to cirrhosis and liver failure, such as drug hepatotoxicity. (medscape.com)
  • Hepatic histological findings after transplantation for chronic hepatitis B virus infection, including a unique pattern of fibrosing cholestatic hepatitis. (medscape.com)
  • What are the symptoms of hepatitis? (medlineplus.gov)
  • Some people with hepatitis do not have symptoms and do not know they are infected. (medlineplus.gov)
  • Signs and symptoms of acute hepatitis E include abdominal pain, anorexia, fever, jaundice, and lethargy, and are indistinguishable from other causes of viral hepatitis. (cdc.gov)
  • Hepatitis A causes mild to severe illness in an estimated 1.4 million people per year, with a further 113 million people being infected but not developing symptoms. (who.int)
  • Although the disease is rarely fatal and patients that recover have a lifelong immunity, it can cause debilitating symptoms and in rarer cases deadly acute liver failure (fulminant hepatitis). (who.int)
  • Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes (jaundice), poor appetite, vomiting, tiredness, abdominal pain, and diarrhea. (wikipedia.org)
  • Hepatitis has a broad spectrum of presentations that range from a complete lack of symptoms to severe liver failure. (wikipedia.org)
  • Chronic hepatitis presents similarly, but can manifest signs and symptoms specific to liver dysfunction with long-standing inflammation and damage to the organ. (wikipedia.org)
  • Acute viral hepatitis follows three distinct phases: The initial prodromal phase (preceding symptoms) involves non-specific and flu-like symptoms common to many acute viral infections. (wikipedia.org)
  • Fever, when present, is most common in cases of hepatitis A and E. Late in this phase, people can experience liver-specific symptoms, including choluria (dark urine) and clay-colored stools. (wikipedia.org)
  • The recovery phase is characterized by resolution of the clinical symptoms of hepatitis with persistent elevations in liver lab values and potentially a persistently enlarged liver. (wikipedia.org)
  • Both drug-induced hepatitis and autoimmune hepatitis can present very similarly to acute viral hepatitis, with slight variations in symptoms depending on the cause. (wikipedia.org)
  • Many people with autoimmune hepatitis have no symptoms. (nih.gov)
  • People with chronic hepatitis C might sometimes have vague general symptoms, like feeling very tired or depressed. (kidshealth.org)
  • The signs and symptoms of acute viral hepatitis result from damage to the liver and are similar regardless of the hepatitis virus responsible. (britannica.com)
  • Hepatitis E is contagious from one week before symptoms start to four weeks afterward. (medicinenet.com)
  • Doctors will look at a variety of factors and symptoms when determining a person's outlook if they have hepatitis C and cirrhosis. (medicalnewstoday.com)
  • The incubation period (from the time of exposure to HBV to symptom development) is long for hepatitis B - the average time to onset of symptoms is about 90, days but may range from 60-150 days. (medicinenet.com)
  • Acute hepatitis B symptoms may last from several weeks up to about 6 months. (medicinenet.com)
  • Hepatitis A does not always cause symptoms. (longbeach.gov)
  • However, it's important to note that hepatitis A can be contagious even in the absence of symptoms. (healthline.com)
  • When hepatitis C is chronic, it can cause symptoms that may be difficult to manage, such as exhaustion, pain, and nausea. (healthline.com)
  • Your doctor may order a hepatitis panel if you have symptoms of hepatitis. (healthlinkbc.ca)
  • This blood test also may be done if you were recently exposed to a hepatitis virus, even if you do not have symptoms. (healthlinkbc.ca)
  • It is important to be aware of the symptoms of hepatitis, so that you get help immediately. (vetinfo.com)
  • There is no treatment for hepatitis and if the dog has severe symptoms, he may die within 1 week. (vetinfo.com)
  • You can't give blood if you currently have symptoms or have ever tested positive for hepatitis C. But you can probably donate organs or tissue, since risk of transmission is low and hepatitis C is curable. (webmd.com)
  • At least three people in Victoria, and two in NSW, who have eaten the frozen berries have since been diagnosed with hepatitis A. Symptoms include abdominal pain, nausea and fever as well as yellow skin and eyes, and anyone experiencing these symptoms is urged to see a doctor. (theage.com.au)
  • HEV-3 and HEV-4 cause hepatitis E in high-income countries, whereas HEV-1, HEV-2, HEV-4, and HEV-7 are associated with disease in low- and middle-income countries. (cdc.gov)
  • Infectious agents that cause hepatitis include viruses and parasites. (britannica.com)
  • Hepatitis C can cause cirrhosis, but cirrhosis cannot cause hepatitis C. This is because a person must have exposure to the virus to get hepatitis C. (medicalnewstoday.com)
  • Indirect spread from items such as razors, toothbrushes, or other items may cause hepatitis B. Unfortunately, HBV is very stable and can remain infective on items like razors or toothbrushes for about one week. (medicinenet.com)
  • Other tests look for antigens or the genetic material ( DNA or RNA ) of the viruses that cause hepatitis. (healthlinkbc.ca)
  • Adenovirus infections do not normally cause hepatitis in healthy children suggesting that a completely new type of adenovirus might have been introduced into the human population. (bmj.com)
  • Universal Adult Hepatitis B Screening and Vaccination as the Path to Elimination. (cdc.gov)
  • Cost-Effectiveness of Hepatitis B Testing and Vaccination of Adults Seeking Care for Sexually Transmitted Infections .Sex Transm Dis. (cdc.gov)
  • Estimating vaccination threshold and impact in the 2017-2019 hepatitis A virus outbreak among persons experiencing homelessness or who use drugs in Louisville, Kentucky, United States. (cdc.gov)
  • Evaluating the Cost-Effectiveness of Hepatitis B Vaccination Strategies in High-impact Settings for Adults. (cdc.gov)
  • Hutton DW, Toy M, Salomon JA, Conners EE, Nelson NP, Harris AM, So S. Cost-Effectiveness of Hepatitis B Testing and Vaccination of Adults Seeking Care for Sexually Transmitted Infections. (cdc.gov)
  • Pediatricians should ensure that babies born to HBV positive persons are followed closely and complete their hepatitis B vaccination series by 6 months of age on a 0-, 1-2-, and 6-month schedule. (mass.gov)
  • Once their vaccination series has been completed, babies should then have Post-Vaccination Serological Testing (PVST) done between 9-12 months of age, or 1-2 months after the last dose of hepatitis b vaccine, if the series was delayed. (mass.gov)
  • There are no specific drugs or treatments to treat and cure hepatitis E, moreover, the only country that has a hep E vaccination is China at this time. (medicinenet.com)
  • While the implementation of vaccination programs and improvements in sanitation have led to a global decrease in hepatitis A cases, it remains a highly contagious virus capable of surviving on surfaces for months . (healthline.com)
  • The New Jersey Department of Health (NJDOH) Hepatitis Services Locator is an interactive directory for finding free or low cost publicly-funded hepatitis services, including vaccination, testing, and treatment. (nj.gov)
  • Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. (medscape.com)
  • The vaccine scheduler table summarizes the current vaccination schedule for young children, adolescents, and adults for Hepatitis B. The data is updated regularly with the most recent official country reporting collected through the WHO/UNICEF joint reporting process. (who.int)
  • The spectrum of illness ranges from asymptomatic to severe disease resulting in fulminant hepatitis and death. (cdc.gov)
  • In rare cases, acute hepatitis E can lead to acute liver failure (fulminant hepatitis) and death. (who.int)
  • Fulminant hepatitis, or massive hepatic cell death, is a rare and life-threatening complication of acute hepatitis that can occur in cases of hepatitis B, D, and E, in addition to drug-induced and autoimmune hepatitis. (wikipedia.org)
  • Complications of acute viral hepatitis include fulminant hepatitis, which is a very severe, rapidly developing form of the disease that results in severe liver failure, impaired kidney function, difficulty in the clotting of blood, and marked changes in neurological function. (britannica.com)
  • Rare complications of hepatitis E include severe ("fulminant") hepatitis, liver failure, and death. (medicinenet.com)
  • These images are a random sampling from a Bing search on the term "Fulminant Hepatitis. (fpnotebook.com)
  • There is a severe and life-threatening form of acute hepatitis referred to as, 'Fulminant,' hepatitis that a very small number of people develop. (disabled-world.com)
  • Some types of hepatitis cause only acute infections. (medlineplus.gov)
  • In the United States today, an estimated one million persons have life long hepatitis B virus infections. (cdc.gov)
  • Hepatitis viruses constitute a major public health problem because of the morbidity and mortality associated with the acute and chronic consequences of these infections. (cdc.gov)
  • The medical definition of hepatitis E is a kind of inflammation and swelling of the liver that is caused by the hepatitis E virus (hep E). There are about 20 million cases of hep E infections per year in the world. (medicinenet.com)
  • Most hep E infections happen in parts of the world that have poor sanitation or unsafe water supplies. (medicinenet.com)
  • Hepatitis is a condition characterized by liver inflammation, often resulting from viral infections, excessive alcohol consumption, or other factors. (healthline.com)
  • To reduce new hepatitis C infections, he said, states need to provide clean syringes for injection drug users who otherwise have no other contact with the health care system than emergency departments and jails. (startribune.com)
  • Contaminated water supplies are often the cause of Hepatitis E infections. (womens-health.co.uk)
  • New research from Boston Medical Center shows that routine Hepatitis C (HCV) testing at federally qualified health centers improves diagnosis rates and health outcomes for people with HCV infections in the United States, and is cost-effective. (news-medical.net)
  • Adenovirus infections might cause the acute hepatitis in children observed. (bmj.com)
  • Approximately fifteen to twenty-five percent of persons with chronic hepatitis B infections die from liver disease. (disabled-world.com)
  • Autoimmune hepatitis is a chronic type in which your body's immune system attacks your liver. (medlineplus.gov)
  • There are vaccines to prevent hepatitis A and B. Autoimmune hepatitis cannot be prevented. (medlineplus.gov)
  • Autoimmune hepatitis may be treated with medications to suppress the immune system. (wikipedia.org)
  • Without treatment, autoimmune hepatitis may get worse and lead to complications, such as cirrhosis. (nih.gov)
  • Experts aren't sure what causes autoimmune hepatitis. (nih.gov)
  • Doctors diagnose autoimmune hepatitis based on a combination of information from your medical history, a physical exam, blood tests, imaging tests, and liver biopsy. (nih.gov)
  • No single test can diagnose autoimmune hepatitis. (nih.gov)
  • Doctors treat autoimmune hepatitis with medicines that suppress your immune system, most often corticosteroids and immunosuppressants. (nih.gov)
  • If autoimmune hepatitis leads to liver failure or liver cancer, you may need a liver transplant. (nih.gov)
  • Doctors may recommend that people who take corticosteroids to treat autoimmune hepatitis also take dietary supplements of calcium and vitamin D to help prevent osteoporosis. (nih.gov)
  • If you have autoimmune hepatitis, you should eat a healthy, well-balanced diet. (nih.gov)
  • The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. (medscape.com)
  • Kim A. Hepatitis C virus. (medscape.com)
  • Toich L. Will hepatitis C virus medication costs drop in the years ahead? (medscape.com)
  • Available at https://www.pharmacytimes.com/resource-centers/hepatitisc/will-hepatitis-c-virus-medicaton-costs-drop-in-the-years-ahead . (medscape.com)
  • Sterling RK, Bralow S. Extrahepatic manifestations of hepatitis C virus. (medscape.com)
  • Mahmoudvand S, Shokri S, Taherkhani R, Farshadpour F. Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma. (medscape.com)
  • Sexual transmission of hepatitis C virus among monogamous heterosexual couples: the HCV partners study. (medscape.com)
  • Vertical transmission of hepatitis C virus: systematic review and meta-analysis. (medscape.com)
  • Hepatitis E is caused by hepatitis E virus (HEV), a spherical, nonenveloped, single-stranded, single-serotype, RNA virus belonging to the Hepeviridae family. (cdc.gov)
  • Have sex with a person infected with hepatitis B virus. (cdc.gov)
  • How is hepatitis B virus spread? (cdc.gov)
  • Some persons infected with hepatitis B virus never fully recover and carry the virus for the rest of their lives. (cdc.gov)
  • Pregnant women who are infected with hepatitis B virus frequently transmit the disease to their babies. (cdc.gov)
  • All pregnant women should be tested early in pregnancy to determine if they are infected with hepatitis B virus. (cdc.gov)
  • New immunization strategies have been developed to eliminate the spread of the hepatitis B virus (HBV) and the hepatitis A virus (HAV) in the United States. (cdc.gov)
  • Circulation of other genotypes of hepatitis A virus in the Eastern Mediterranean Region presently remain unknown. (who.int)
  • The Hepatitis E virus has at least four different genotypes, of which two have been found only in humans. (who.int)
  • Hepatitis is most commonly caused by the virus hepatovirus A, B, C, D, and E. Other viruses can also cause liver inflammation, including cytomegalovirus, Epstein-Barr virus, and yellow fever virus. (wikipedia.org)
  • A variety of tools are available from the Immunization Action Coalition, including Guidance for Developing Admission Orders in Labor & Delivery and Newborn Units to Prevent Hepatitis B Virus Transmission and Labor & Delivery HBsAg Admission Checklist for Birthing Mother . (mass.gov)
  • Acute hepatitis C is a short-term illness that happens within 6 months of when a person is exposed to the virus. (kidshealth.org)
  • Chronic hepatitis C is when a person still has the virus in their body after 6 months. (kidshealth.org)
  • We also participate in nationwide studies investigating the way the body's immune system fights the hepatitis B virus with the goal of improving the treatment of chronic hepatitis B. (massgeneral.org)
  • We regularly assess each patient's response to antiviral medication to ensure the hepatitis B virus does not become resistant to the medications. (massgeneral.org)
  • The hepatitis E virus exists throughout the world. (medicinenet.com)
  • Even though hepatitis E virus is uncommon in the U.S., surveys have shown that up to 20% of Americans have antibodies to it and have probably been exposed. (medicinenet.com)
  • Hepatitis C is a virus that people contract when they come into contact with the blood of someone who has hepatitis C. (medicalnewstoday.com)
  • This is true in about 15 to 25 percent of people who contract the hepatitis C virus, according to the CDC. (medicalnewstoday.com)
  • Cirrhosis due to the hepatitis C virus usually takes decades to develop. (medicalnewstoday.com)
  • Hepatitis E is a virus that infects your liver . (webmd.com)
  • The hepatitis E virus spreads through poop . (webmd.com)
  • No vaccine can prevent the hepatitis E virus. (webmd.com)
  • Persons infected with hepatitis B can pass the virus to others through blood or body fluids. (medicinenet.com)
  • To avoid confusion , the term hepatitis B will be used to indicate liver disease and HBV will be used to designate the infecting virus. (medicinenet.com)
  • [ 1 , 2 ] It is caused by the hepatitis E virus (HEV) and is spread by fecally contaminated water within endemic areas or through the consumption of uncooked or undercooked meat. (medscape.com)
  • Hepatitis E has many similarities with hepatitis A . Hepatitis E has been associated with chronic hepatitis in solid-organ transplant recipients, patients infected by human immunodeficiency virus (HIV), and in an individual on rituximab treatment for non-Hodgkin lymphoma. (medscape.com)
  • The hepatitis E virus (HEV) genome contains three open reading frames (ORFs). (medscape.com)
  • Hepatitis A usually spreads when a person unknowingly ingests the virus from objects, food, or drinks contaminated by small, undetected amounts of stool from an infected person. (longbeach.gov)
  • Hepatitis A is a liver disease caused by the hepatitis A virus. (longbeach.gov)
  • Hepatitis A is a highly contagious virus that targets the liver. (healthline.com)
  • One specific type of viral hepatitis is hepatitis A, which is caused by the hepatitis A virus (HAV) and primarily transmitted through contaminated food or water. (healthline.com)
  • It's caused by the hepatitis A virus (HAV), which belongs to a family of viruses called picornaviruses. (healthline.com)
  • Hepatitis C virus (HCV) results in more lost years of life and more illness than any infectious disease in Ontario. (cmaj.ca)
  • Hepatitis C virus affects 250 000 to 400 000 Canadians and may lead to progressive liver fibrosis. (cmaj.ca)
  • Hepatitis E is hyperendemic in many developing countries in Asia and Africa, and is caused by hepatitis E virus (HEV) genotypes 1 and 2, which are spread via the faecal-oral route by contaminated water. (nature.com)
  • Figure 2: Brachial plexograms of eight patients with hepatitis E virus-associated neuralgic amyotrophy. (nature.com)
  • Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. (nature.com)
  • Like Hepatitis A, this virus is commonly spread through "fecal-oral transmission," which occurs when a person eats or drinks something that has been contaminated with the feces of someone infected with HEV. (womens-health.co.uk)
  • The Hepatitis E Virus (HEV) is an emerging zoonotic pathogen in Europe that affects humans, doing damage to the liver and also to other organs, such as the kidney and the central nervous system. (eurekalert.org)
  • The results of the study confirmed that captive lynxes have a higher risk of exposure to Hepatitis E Virus than animals in the wild. (eurekalert.org)
  • While wild lynxes mainly consume wild rabbits, and previous studies carried out by this same group have shown that there is hardly any circulation of the Hepatitis E Virus in their populations, captive lynxes feed mainly on farm rabbits, and there are studies that have found virus circulation in these rabbits in Italy and France, although the presence of the virus in these animals in Spain has not yet been evaluated. (eurekalert.org)
  • Finally, the study has also discovered the presence of the genotype 3f of the hepatitis E virus in lynxes, which is the most frequent one in infected people in Spain. (eurekalert.org)
  • Adults should be tested for hepatitis B virus (HBV) at least once in their lifetime, according to updated guidelines from the Centers for Disease Control and Prevention (CDC). (medscape.com)
  • Scientists have identified a new immunotherapy to combat the hepatitis B virus (HBV), the most common cause of liver cancer in the world. (sciencedaily.com)
  • Hepatitis A (formerly known as ''infectious hepatitis'') is an acute infectious disease of the liver caused by the hepatitis A virus (HAV), which is most commonly transmitted by the fecal-oral route via contaminated food or drinking water. (news-medical.net)
  • Thermo Fisher Scientific, the world leader in serving science, today announced the availability of the Thermo Scientific MAS Omni Infectious Disease quality control sets for monitoring serological assays for analytes such as HIV 1&2, Hepatitis B & C virus, Syphilis and HTLV I/II. (news-medical.net)
  • Hepatitis B is transmitted when blood, semen, or another body fluid from a person infected with the virus enters the body of someone who is not infected. (health.mil)
  • There is a vaccine that can be administered to prevent catching the virus and hepatitis. (vetinfo.com)
  • Hepatitis in dogs can be prevented through the administration of the vaccine against the hepatitis virus. (vetinfo.com)
  • If you think you have been recently infected with hepatitis B, it can take up to 9 weeks before the virus will be detected in your blood. (hepb.org)
  • If you've just been diagnosed with hepatitis C, you may wonder how you got it and worry about passing on the virus to a loved one. (webmd.com)
  • While the odds of passing on the hepatitis C virus are low, you should still tell anyone at risk that you have hepatitis C. You should tell sexual partners, spouses, and family members. (webmd.com)
  • According to the first, dogs could be the source of the hitherto unknown pathogen - a virus, most likely - responsible for the recent outbreak of "severe acute hepatitis" detected among pediatric patients from UK and other European (including Italy) and non-European (including USA) Countries. (bmj.com)
  • Viral Entry The envelope proteins of HCV form a heterodimer which helps binding the hepatitis C virus to the receptors present on the hepatocytes membrane. (bartleby.com)
  • This research paper is going to review today's silent killer, the Hepatitis C virus. (bartleby.com)
  • Hepatitis C virus (HCV) is from the virus family Flaviviridae with an RNA envelope serving as it's genetic material. (bartleby.com)
  • Hepatitis C is an enveloped virus, and the RNA also lacks a proofreading ability after replication, which results in mutations coding for many genotypes within the host. (bartleby.com)
  • People become infected with hepatitis A by swallowing the virus. (nj.gov)
  • Hepatitis A is spread when traces of faecal matter containing the virus come in contact with hands, water or food and then enter a person's mouth. (theage.com.au)
  • The acute phase of hepatitis B is short-term and happens soon after a person has been exposed to the HBV virus. (disabled-world.com)
  • The HBV virus is one of the leading causes of infectious hepatitis. (disabled-world.com)
  • The average incubation period for hepatitis B is thirty to one-hundred and eighty days, although the HBV virus can be detected between thirty and sixty days after a person has become infected. (disabled-world.com)
  • Hepatitis B, Acute Acute hepatitis B is inflammation of the liver that is caused by the hepatitis B virus and that lasts from a few weeks up to 6 months. (msdmanuals.com)
  • Hepatitis A Acute hepatitis A is inflammation of the liver that is caused by the hepatitis A virus and that lasts less than 6 months. (msdmanuals.com)
  • However, if people who have been vaccinated are exposed to the virus, a doctor measures their antibody levels against hepatitis B. If the antibody levels are low, they may need another injection of hepatitis B vaccine. (msdmanuals.com)
  • McMahon BJ, Holck P, Bulkow L, Snowball M. Serologic and clinical outcomes of 1536 Alaska Natives chronically infected with hepatitis B virus. (medscape.com)
  • Occurrence of hepatocellular carcinoma and decompensation in western European patients with cirrhosis type B. The EUROHEP Study Group on Hepatitis B Virus and Cirrhosis. (medscape.com)
  • Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. (medscape.com)
  • Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. (medscape.com)
  • Chisari FV, Ferrari C. Hepatitis B virus immunopathology. (medscape.com)
  • In 2018, 12,474 hepatitis A cases were reported in the United States, according to the Centers for Disease Control and Prevention (CDC) . (healthline.com)
  • After declining for two decades, new hepatitis C cases shot to an estimated 34,000 in 2015, nearly triple the number in 2010, according to a recent report from the U.S. Centers for Disease Control and Prevention. (startribune.com)
  • For more information, see the Centers for Disease Control and Prevention's (CDC) Hepatitis B vaccine information statement . (msdmanuals.com)
  • Vials are stored under appropriate frozen (-30°C) conditions until they are shipped to Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention for testing. (cdc.gov)
  • Number of facilities that are allocated to viral hepatitis prevention, care and Yes able to offer serological able to offer nucleic acid treatment? (who.int)
  • As with Hepatitis A, prevention efforts focus on raising awareness and maintaining safe water, proper sanitation, and proper hygiene. (who.int)
  • 204 infants born in 2021 were case managed by the Perinatal Hepatitis B Prevention Program (PHBPP). (mass.gov)
  • Unfortunately, there's no vaccine to protect against hepatitis C. Prevention means avoiding risky behaviors that can spread HCV, especially injecting drugs. (kidshealth.org)
  • The first-ever World Hepatitis Summit kicked off today in Glasgow, Scotland, where health officials are urging countries to develop national hepatitis treatment and prevention programs. (voanews.com)
  • World Hepatitis Day is observed each year on 28 July to raise awareness of viral hepatitis, an inflammation of the liver that causes severe liver disease and hepatocellular cancer. (bvsalud.org)
  • Chronic hepatitis can lead to complications such as cirrhosis (scarring of the liver), liver failure, and liver cancer . (medlineplus.gov)
  • Early diagnosis and treatment of chronic hepatitis may prevent these complications. (medlineplus.gov)
  • Gilead has countered that the cost of the drug is lower than the cost of complications associated with hepatitis C treatment, such as liver damage or liver failure. (genengnews.com)
  • If a person has a hepatitis C diagnosis, they may first ask what treatments their doctor recommends. (medicalnewstoday.com)
  • Several factors explain why the risk of depression goes up following a hepatitis C diagnosis. (healthline.com)
  • It's common for people who learn that they have hepatitis C to experience a range of emotions about the diagnosis. (healthline.com)
  • Diagnosis and treatment for hepatitis A. (canada.ca)
  • hepatitis B antigens (HBsAg) can be detected as well as antibodies (anti-HBs) that are developed against hepatitis B antigens. (medicinenet.com)
  • Pregnant people who have already received timely triple panel screening for hepatitis B and who have no new HBV exposures only need HBsAg screening, the guidelines state. (medscape.com)
  • Hepatitis B surface antigen (HBsAg). (healthlinkbc.ca)
  • A safe and effective vaccine is available to prevent hepatitis A, which is a part of routine national children immunization programs in Saudi Arabia, Bahrain, and Iraq. (who.int)
  • There is no vaccine to prevent hepatitis C, but medical innovations in recent years mean that oral treatments can cure most people. (medicalnewstoday.com)
  • How to prevent hepatitis A. (canada.ca)
  • The best way to prevent Hepatitis A is to get vaccinated. (cabrillo.edu)
  • It is caused by one of several viruses -- hepatitis viruses A , B , C , D, and E. In the United States, A, B, and C are the most common. (medlineplus.gov)
  • In addition, NHANES provides the means to better define the epidemiology of other hepatitis viruses. (cdc.gov)
  • DVH laboratory branch participates in outbreak investigations related to hepatitis viruses by performing routine and state of the art serologic and molecular methodologies on clinical samples collected from affected patients. (cdc.gov)
  • and a number of hepatitis viruses. (britannica.com)
  • The term viral hepatitis , however, usually is applied only to those cases of liver disease caused by the hepatitis viruses. (britannica.com)
  • There are five different hepatitis viruses: A, B, C, D and E. All cause inflammation of the liver, but two strains, B and C, cause most deaths and are responsible for 80 percent of all liver cancer fatalities. (voanews.com)
  • Epidemiology of hepatitis B and C viruses: a global overview. (medscape.com)
  • Yu MC, Yuan JM, Ross RK, Govindarajan S. Presence of antibodies to the hepatitis B surface antigen is associated with an excess risk for hepatocellular carcinoma among non-Asians in Los Angeles County, California. (medscape.com)
  • Hepatitis is inflammation of the liver . (medlineplus.gov)
  • Hepatitis is inflammation of the liver tissue. (wikipedia.org)
  • Cases of drug-induced hepatitis can manifest with systemic signs of an allergic reaction including rash, fever, serositis (inflammation of membranes lining certain organs), elevated eosinophils (a type of white blood cell), and suppression of bone marrow activity. (wikipedia.org)
  • hepatitis , inflammation of the liver that results from a variety of causes, both infectious and noninfectious. (britannica.com)
  • Another complication is chronic hepatitis, which is characterized by liver cell death and inflammation over a period greater than six months. (britannica.com)
  • Hepatitis C is more common in adults than in children. (kidshealth.org)
  • Hepatitis C doesn't kill children or adults in the prime of life. (startribune.com)
  • Perinatal HBV transmission can be prevented by identifying HBV positive pregnant persons and providing hepatitis B immune globulin and hepatitis B vaccine to their infants within 12 hours of birth. (mass.gov)
  • He says the approach should be similar to that taken for HIV/AIDS, to which Hepatitis shows similar roots of transmission. (voanews.com)
  • Hepatitis C transmission in medical settings is highly preventable and there are clear guidelines and standards to keep patients safe," says Dr. Defendorf. (eurekalert.org)
  • Since the nature of transmission is fecal-oral, Hepatitis E tends to be seen more commonly in areas where there are poor sanitary conditions or where personal hygiene is not prevalent. (womens-health.co.uk)
  • The consumption of products derived from infected animals is considered the main route for the transmission of Hepatitis E in humans, and has also been suggested for other animal species, including felines. (eurekalert.org)
  • There are different ways to prevent or lower your risk for hepatitis, depending on the type of hepatitis. (medlineplus.gov)
  • Hepatitis C is the most serious type of hepatitis. (kidshealth.org)
  • People with hepatitis E should not (any type of hepatitis) drink alcohol . (medicinenet.com)
  • Who is at risk for hepatitis? (medlineplus.gov)
  • How great is the risk for hepatitis B? (cdc.gov)
  • If you engage in certain behaviors, your risk for hepatitis B may be much higher. (cdc.gov)
  • Because women of reproductive age are part of this group, experts worry that more newborns will be at risk for hepatitis C. (kidshealth.org)
  • Who's at Risk for Hepatitis C? (webmd.com)
  • Consumption of shellfish was implicated in an outbreak of hepatitis E on a cruise ship. (cdc.gov)
  • HCV guidance: Recommendations for testing, managing, and treating hepatitis C. Updated: May 24, 2018. (medscape.com)
  • A person can only contract hepatitis C through exposure to certain bodily fluids, such as blood, of a person who is living with the condition. (healthline.com)
  • Hepatitis C is spread only through exposure to an infected person's blood. (webmd.com)
  • Why is hepatitis B so serious in pregnant women? (cdc.gov)
  • Hepatitis E can be very serious, especially for pregnant women. (medicinenet.com)
  • But hepatitis E can be dangerous for pregnant women or anyone with weak immune systems, including the elderly or people who are ill. (webmd.com)
  • If your chronic hepatitis leads to liver failure or liver cancer, you may need a liver transplant . (medlineplus.gov)
  • Acute hepatitis can resolve on its own, progress to chronic hepatitis, or (rarely) result in acute liver failure. (wikipedia.org)
  • Chronic hepatitis may progress to scarring of the liver (cirrhosis), liver failure, and liver cancer. (wikipedia.org)
  • Chronic viral hepatitis E can cause cirrhosis (liver scarring) over time that leads to liver failure. (medicinenet.com)
  • With exceptionally high cure rates, shorter treatment duration and fewer side-effects than existing therapies, interferon-free medicines hold the key to preventing liver cirrhosis, liver cancer and liver failure - not to mention halting the rising death toll associated with untreated hepatitis C. (smh.com.au)
  • Although a commercially available drug is not yet available to cure hepatitis B, researchers in Australia are currently studying an anticancer drug, birinapant. (medicinenet.com)
  • The drug is in clinical trials to determine its potential ability to cure hepatitis B. (medicinenet.com)
  • These new treatments cure hepatitis C and represent a lifeline for many people. (smh.com.au)
  • What it does for me as a GP is allow me to prescribe medications that cure hepatitis C secure in the knowledge my patients will get what they need. (smh.com.au)
  • In 2014, the United States Food and Drug Administration (FDA) approved drug treatments called direct-acting antiviral medications that were available in oral form only to treat hepatitis C, according to the journal Open Forum Infectious Diseases . (medicalnewstoday.com)
  • Several medications to treat hepatitis C have met FDA approval since then. (medicalnewstoday.com)
  • There is no specific medication to treat hepatitis A and most people recover on their own. (nj.gov)
  • No specific treatment exists, although people who develop chronic hepatitis E benefit from antiviral treatment. (who.int)
  • Antiviral medications are recommended in all with chronic hepatitis C, except those with conditions that limit their life expectancy. (wikipedia.org)
  • Newer medications for hepatitis C, known as direct-acting antiviral drugs, have fewer common side effects than interferon. (healthline.com)
  • HALT-C (Hepatitis C Antiviral Long-term Treatment against Cirrhosis) trial website. (medscape.com)
  • Hepatitis D can only infect people already infected with hepatitis B. Hepatitis A, B, and D are preventable with immunization. (wikipedia.org)
  • Hospitals with a hepatitis B birth dose administration rate of ≥90% over a 12-month period can apply to be on the Immunization Action Coalition's Birth Dose Honor Roll . (mass.gov)
  • Hepatitis in dogs can be acute or more severe. (vetinfo.com)
  • Acute hepatitis can be treated, while the severe form may be fatal. (vetinfo.com)
  • During hepatitis E outbreaks, clinical attack rates are highest among people aged 15-49 years. (cdc.gov)
  • Although the actual burden of hepatitis A in the Eastern Mediterranean Region remains unknown but outbreaks have repeatedly occurred in displaced population and refugee settings of countries affected by crisis or humanitarian emergencies. (who.int)
  • CDC and partners ensure rapid and coordinated surveillance, detection, and response to hepatitis outbreaks. (cdc.gov)
  • Most outbreaks of hepatitis E occur in Southeast and East Asia. (medicinenet.com)
  • The new recommendations now contrast with the 2020 screening guidelines issued by the US Preventive Services Task Force (USPSTF) that recommend risk-based screening for hepatitis B. (medscape.com)
  • 3.3 million cases are symptomatic hepatitis E, and ≈70,000 deaths occur. (cdc.gov)
  • Hepatitis C is commonly spread through infected blood such as may occur during needle sharing by intravenous drug users. (wikipedia.org)
  • Hepatitis results in more than a million deaths a year, most of which occur indirectly from liver scarring or liver cancer. (wikipedia.org)
  • In the United States, hepatitis A is estimated to occur in about 2,500 people a year and results in about 75 deaths. (wikipedia.org)
  • Cirrhosis is scarring of the liver that can occur from hepatitis C and other conditions. (medicalnewstoday.com)
  • Emerging treatments for hepatitis C may help to reduce the likelihood that hepatitis C-related liver cirrhosis will occur. (medicalnewstoday.com)
  • Hepatitis C and depression are two separate health conditions that can occur at the same time. (healthline.com)
  • Babies born to HBV positive persons should receive HBIG and their first dose of hepatitis B vaccine within 12 hours of birth. (mass.gov)
  • All newborns, regardless of the birth parent's HBV status, should receive their first dose of hepatitis B vaccine within 24 hours of birth. (mass.gov)
  • Over 99% of these infants received treatment (HBIG and first dose of hepatitis B vaccine) at birth, 95% completed the vaccine series by 12 months of age, and 84% completed the vaccine series and received PVST by December 31, 2021. (mass.gov)
  • The first dose of hepatitis B vaccine is given at birth, with the three-dose series completed between 6 and 18 months of age. (health.mil)
  • The best way to be protected from hepatitis B is to be vaccinated with hepatitis B vaccine, which has been proven safe and effective. (cdc.gov)
  • Hepatitis C. However, the majority of these notification events were discovered only after patients became acutely ill rather than through proactive reporting of violations of health safety protocols, according to a review in The Journal of the American Osteopathic Association . (eurekalert.org)
  • Not all patients with hepatitis B require treatment, which is generally used in more advanced diseases. (medicinenet.com)
  • In the meantime, we always encourage clinicians to use their judgment as they provide care for their patients - including those who may benefit from screening for hepatitis B - and to decide together with each patient which preventive services can best help them live a long and healthy life," Barry said. (medscape.com)
  • The combination is designed to interfere with HCV replication and be used as a treatment for hepatitis patients with genotypes 1a or 1b without PEG-interferon. (genengnews.com)
  • Hepatitis B is a serious public health problem that affects people of all ages in the United States and around the world. (cdc.gov)
  • In the United States, NASH affects about 11 million people and alcoholic hepatitis affects about 5 million people. (wikipedia.org)
  • The fact that hepatitis C is a condition that affects millions of people should mean the drugs cost less. (medicalnewstoday.com)
  • The canine hepatitis is confused with the hepatitis B, which indeed affects humans. (vetinfo.com)
  • Viral hepatitis is a global public health problem that affects millions of people every year, causing disability and death. (bvsalud.org)
  • Medications may be used to treat chronic viral hepatitis. (wikipedia.org)
  • This article details information about hepatitis C medications, and how, under certain circumstances, people may be able to access help to pay for them. (medicalnewstoday.com)
  • Researchers are continuing to create medications that shorten the duration of treatment for hepatitis C. (medicalnewstoday.com)
  • Some evidence suggests that certain medications for hepatitis C may cause depression as a side effect of treatment. (healthline.com)
  • Keep in mind, newer medications for hepatitis C completely cure the condition in more than 90 percent of people . (healthline.com)
  • In 5 to 10% of people, hepatitis B becomes chronic and can lead to cirrhosis and liver cancer. (msdmanuals.com)
  • In doing so, countries can save lives and reduce the costs associated with long-term care for cirrhosis and liver cancer as a result of untreated hepatitis. (bvsalud.org)
  • Travel internationally to areas with a high prevalence of hepatitis B. (cdc.gov)
  • Hepatitis E does not cause chronic hepatitis except in some people with weak immune systems, especially after organ transplantation. (medicinenet.com)
  • Hepatitis C is a contagious liver disease that is primarily spread through the blood of an infected person or, less commonly, through sexual contact. (eurekalert.org)
  • Treatment of chronic hepatitis C with recombinant interferon alfa. (medscape.com)
  • People who drink a lot over long periods of time are at risk for alcoholic hepatitis. (medlineplus.gov)
  • People who have alcoholic hepatitis need to stop drinking. (medlineplus.gov)
  • For most people, hepatitis E is a mild, self-limited disease. (cdc.gov)
  • An estimated 20 million people are infected with hepatitis E every year, leading to 3.3 million symptomatic cases. (who.int)
  • Worldwide in 2015, hepatitis A occurred in about 114 million people, chronic hepatitis B affected about 343 million people and chronic hepatitis C about 142 million people. (wikipedia.org)
  • How Do People Get Hepatitis C? (kidshealth.org)
  • Fortunately, medicines can now treat people with hepatitis C and cure them in most cases. (kidshealth.org)
  • Great progress has been made in treating and even curing hepatitis C. Oral medicines now can cure HCV for many people within 3 months. (kidshealth.org)
  • Health experts caution that people who had hepatitis C due to drug use should get counseling or further treatment to help them overcome their addiction. (kidshealth.org)
  • Some insurance companies will pay for people whose hepatitis C has not responded to less-expensive treatments or for those who are already showing signs of liver damage . (medicalnewstoday.com)
  • Chronic hepatitis E is more common in most people with hepatitis C . However, hep E occurs less often than hep B , and very rarely, with hep E can become chronic in people whose immunity is suppressed by drugs given to prevent rejection of a transplanted organ. (medicinenet.com)
  • Again, according to the CDC, for every 100 people with hepatitis C, an estimated 10 to 20 will develop cirrhosis over the following 20 to 30 years. (medicalnewstoday.com)
  • People with hepatitis C and cirrhosis should talk to their doctor about strategies that can prevent further damage. (medicalnewstoday.com)
  • We really need governments, civil society, private companies to make people aware,' said Dr. Stefan Wiktor, the team leader of the WHO's Global Hepatitis Program, who attended the conference. (voanews.com)
  • There are about 240 million people with chronic Hepatitis B and between 130 and 150 million for Hepatitis C. (voanews.com)
  • Most people with hepatitis E get better within a few months. (webmd.com)
  • Although rare, hepatitis A can cause death in some people. (longbeach.gov)
  • The irony is that now that people are starting to worry about drug users because they're entering the mainstream population, it's going to help hepatitis get the attention it deserves. (startribune.com)
  • When that recommendation was published, the Task Force was aligned with several other organizations, including the CDC, in supporting screening for hepatitis B in high-risk populations - and importantly, we're all still aligned in making sure that people get the care that they need," said Michael Barry, MD , chair of the USPSTF, in an emailed statement to Medscape Medical News . (medscape.com)
  • Several studies have shown that people who are diagnosed with a hepatitis C have higher rates of depression compared to other groups. (healthline.com)
  • In one report , researchers noted that someone with hepatitis C may be 1.4 to 4 times more likely to experience depression, compared to people with hepatitis B or the general population. (healthline.com)
  • They also suggest that about one-third of people with hepatitis C also have depression. (healthline.com)
  • One out of every one hundred people in the general population has Hepatitis C, but the ratio is higher in prisons. (bartleby.com)
  • Those countries account for more than 100 million people living with hepatitis C, representing 54% of the world's total infected population. (genengnews.com)
  • Anyone can get hepatitis A. Some people at high-risk include men who have sex with men, people who travel to countries where hepatitis A is common, and people who use street drugs (injected or non-injected). (nj.gov)
  • Hepatitis A is found in the stool of infected people. (nj.gov)
  • Hepatitis A is usually spread when people ingest something that has. (msdmanuals.com)
  • The hepatitis B vaccine is recommended for all people up to age 59 who were not previously vaccinated. (msdmanuals.com)
  • Hepatitis E. Lancet 379 , 2477-2488 (2012). (nature.com)
  • Molecular virology and pathogenesis of hepatitis B. Lancet . (medscape.com)
  • Recently hepatitis A genotype 1B has been detected in Syria. (who.int)
  • While hepatitis E genotype 1 has been detected in Afghanistan, Iran (Islamic Republic of), Iraq, Libya, Morocco and Sudan, both the hepatitis E genotype 1 and 2 were detected in Egypt amongst the Eastern Mediterranean Region countries. (who.int)
  • The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007. (medscape.com)
  • What are the treatments for hepatitis? (medlineplus.gov)
  • According to the Pharmacy Times , the cost of treatment can be as low as $54,600 for the 12-week course and the entry to the market of new, cheaper drugs is likely to continue to bring the cost of hepatitis C treatments down. (medicalnewstoday.com)
  • The level of insurance cover for hepatitis C treatments can vary, depending on a person's insurance policy and overall health. (medicalnewstoday.com)
  • For example, not drinking too much alcohol can prevent alcoholic hepatitis. (medlineplus.gov)