Hepatitis B Surface Antigens
Hepatitis B virus
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
Hepatitis B Antibodies
Hepatitis B Vaccines
Hepatitis B Antigens
Hepatitis B Core Antigens
Hepatitis B, Chronic
Hepatitis B e Antigens
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Viral Hepatitis Vaccines
Hepatitis, Viral, Human
INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS, a defective RNA virus that can only infect HEPATITIS B patients. For its viral coating, hepatitis delta virus requires the HEPATITIS B SURFACE ANTIGENS produced by these patients. Hepatitis D can occur either concomitantly with (coinfection) or subsequent to (superinfection) hepatitis B infection. Similar to hepatitis B, it is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Hepatitis C Antibodies
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Hepatitis Delta Virus
Hepatitis C, Chronic
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Hepatitis A Antibodies
Pregnancy Complications, Infectious
Infectious Disease Transmission, Vertical
Hepatitis D, Chronic
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Hepatitis A Antigens
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Hepatitis B Virus, Duck
Hepatitis A virus
Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
Amino Acid Sequence
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Hepatitis A Vaccines
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Reagent Kits, Diagnostic
Reverse Transcriptase Inhibitors
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Hepatitis E virus
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Hepatitis A Virus, Human
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Viral Envelope Proteins
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Liver Function Tests
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Cell Migration Inhibition
Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
Complement Fixation Tests
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Hepatitis B Virus, Woodchuck
False Positive Reactions
Sensitivity and Specificity
Evaluation Studies as Topic
Drug Resistance, Viral
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Hepatitis C Antigens
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.
Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Recombinant Fusion Proteins
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Sequence Analysis, DNA
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
L Cells (Cell Line)
Murine hepatitis virus
Complement fixing hepatitis B core antigen immune complexes in the liver of patients with HBs antigen positive chronic disease. (1/2532)One hundred and fifty-two biopsies from serologically HBsAg positive and negative patients with liver disease were studied in immunofluorescence: for the presence of the surface (HBs) and the core (HBc) antigenic determinants foeterminants of the hepatitis B virus, of immunoglobulins and complement (C) deposits, and for the capacity to fix human C. Circumstantial evidence is presented suggesting that HBc immune-complexes are a relevant feature in the establishment and progression of chronic HBSAg liver disease. C fixation by liver cells was shown in all HBC positive patients with chronic hepatitis; an active form was present in every case, except two with a persistent hepatitis, an inverse ratio of HBc to C binding fluorescence being noted between active chronic hepatitis and cirrhotic patients. HBc without C fixation was observed in only three patients in the incubation phase of infectious hepatitis. IgG deposits were often found in HBc containing, C fixing nuclei. No C binding or IgG deposits were observed in acute self-limited type B hepatitis, in serologically positive patients with normal liver or minimal histological lesions, with and without HBs cytoplasmic fluorescence in their biopsy, or in serologically negative individuals. (+info)
Prevalence of hepatitis B surface antigen and antibody in white and black patients with diabetes mellitus. (2/2532)The prevalence of hepatitis B surface antigen (HBSAg) and antibody (anti-HBS) was determined in 531 white and 519 black diabetic outpatients and in appropriate white and black control populations. There was no difference between the prevalence of either HBSAg or anti-HBS in either the white or black diabetics and that in the white and black controls. These findings make it unlikely that the vast majority of patients with diabetes mellitus have either an increased susceptibility to infection by the hepatitis B virus or an impaired ability to clear the virus once they are infected. (+info)
A cellular protein which binds hepatitis B virus but not hepatitis B surface antigen. (3/2532)The envelope of hepatitis B virus (HBV) consists of three related proteins known as the large (L), middle (M) and small (S) hepatitis B surface antigens (HBsAg). L-HBsAg has a 108-119 amino acid extension at the N terminus compared with M-HBsAg and contains the preS1 sequence of the HBV envelope. Previous research has identified this region as the likely virus attachment protein which is thought to interact with the cellular receptor for the virus. However, as the receptor has still not been identified unequivocally, we used the preS1 region of L-HBsAg to screen a human liver cDNA library by the yeast two-hybrid system. Several positive clones were isolated which encoded cellular proteins that interacted with the HBV preS1 protein. The specificity was examined in an independent manner in experiments in which baculovirus-derived glutathione S-transferase (GST)-preS1 was incubated with 35S-labelled protein expressed by in vitro translation from the positive clones. The intensity of the interactions using this alternative approach mirrored those observed in the yeast two-hybrid system and two proteins (an unidentified protein and a mitochondrial protein) were selected for further study. The specificity of the binding reaction between the preS1 protein and these two proteins was further confirmed in a competition assay; HBV purified from serum, but not purified HBsAg, was able to compete with preS1 and thus block GST-preS1 binding to the unidentified protein but not to the mitochondrial protein. The unidentified protein was then expressed as a fusion protein with GST and this was able to bind HBV virions in a direct manner. (+info)
Leucocyte migration inhibition with inner and outer membranes of mitochondria and insoluble hepatocyte surface membranes prepared from rat liver in patients with chronic hepatitis and cirrhosis. (4/2532)Patients with chronic liver disease were tested for delayed hypersensitivity to the outer and the inner membranes of mitochondria (OMM and IMM) and the insoluble hepatocyte-surface membranes (IHSM), prepared from rat livers, by means of leucocyte migration inhibition technique. Positive reaction to OMM was found in 37% of patients with chronic persistent hepatitis and 35% of those with chronic active hepatitis and 43% of those with liver cirrhosis (P less than 0-05). That to IMM was 55%, 43% and 36% (P less than 0-05) and to IHSM was 37%, 47% and 45% respectively (P less than 0-05). IHSM was found to contain liver-specific components and patients with positive response to IHSM did not reveal at all a positive reaction to rat renal cell-surface membranes. The incidence of positive response to IHSM was significantly higher (54-2%) in patients with the present or previous infection with HBAg than in HBAg-non-infected patients (21-4%) (P less than 0-05). And there seemed to be a good correlation between a degree of cellular response to purified HBsAg and that to IHSM in these HBAg-infected patients. No correlation, however, was found between that to purified HBsAg and that to OMM or IMM in the same patients. This suggested that the cellular response to either HBsAg or IHSM, both related closely, may play a role in the perpetuation of chronic liver disease. (+info)
Hepatitis B virus (HBV)-transgenic mice as an investigative tool to study immunopathology during HBV infection. (5/2532)An overview is given regarding the use of hepatitis B virus (HBV) transgenic mice as an animal model of the HBV-carrier state. Initially, we show how HBV-transgenic mice have contributed insights into the immunopathobiological processes during HBV infection and later, we show how this new information from the experiments with HBV-transgenic mice could be used to develop new methods to combat HBV infection. By microinjecting the full or selected parts of the HBV-genome into the fertilized eggs of inbred mice, different laboratories have developed different lines of HBV-transgenic mice, which express products of the HBV genome and also show signs of HBV replication. Studies in HBV-transgenic mice have provided insights into the process of destruction of hepatocytes, the critical role of cytokines in controlling HBV replication and gene expression, mechanisms underlying the immune response defect in chronic HBV-carriers and the critical role of antigen presenting cells (APC), especially that of antigen presenting dendritic cells in persistent HBV infection. All this new information has given us a better understanding about HBV immunopathobiology, and has led to the development of new therapeutic approaches to combat HBV infection. (+info)
Low prevalence of hepatitis B markers among Mexican female sex workers. (6/2532)OBJECTIVES: To estimate the prevalence and associated risk factors of hepatitis B virus (HBV) serological markers in female sex workers (FSW) in Mexico City. METHODS: The study population consisted of 1498 FSW who attended a detection centre for human immunodeficiency virus (HIV) in Mexico City, between January and October 1992. Study participants responded to a standardised questionnaire and provided a blood sample for serology of syphilis, HIV, and HBV. RESULTS: A total of 0.2% (95% CI 0.1-0.3) of the population were hepatitis B surface antigen (HBsAg) carriers. The general prevalence of antibodies to hepatitis B core antigen (anti-HBc) was 6.3% (95% CI 5.5-7.1). This marker of previous exposition to HBV, was independently associated by logistic regression multivariate analysis with age, working in the street, and history of blood transfusion (BT) before 1987 (OR 4.8, 95% CI 2.1-11.3). Syphilis prevalence was 7.6% (95% CI 6.2-8.9) and HIV prevalence was 0.1% (95% CI 0-0.3). CONCLUSIONS: The prevalence of HBV infection in this group of Mexican FSW is lower than previously reported in other countries. In addition, the frequency of HBsAg carriers is similar to that in the general Mexican population. The absence of two major risk factors for HBV transmission in this group of FSW--that is, injecting drug use and anal intercourse, could help to explain this finding. However, the positive association between anti-HBc and history of blood transfusion demonstrated here, highlights the need to reinforce strict control of blood supplies in Mexico. (+info)
Intracellular retention of hepatitis B virus surface proteins reduces interleukin-2 augmentation after genetic immunizations. (7/2532)We have previously shown that hepatitis B virus (HBV) surface antigens (HBsAgs) are highly immunogenic after genetic immunization. Compared to the secreted middle HBV surface proteins (MHBs) or small HBV surface proteins (SHBs), the nonsecreted large HBV surface protein (LHBs), however, induced significantly weaker humoral and cellular immune responses that could not be augmented by genetic coimmunizations with cytokine expression plasmids. In order to understand the mechanisms underlying this phenomenon, we examined the effect of coimmunizations with an interleukin-2 (IL-2) DNA expression plasmid on the immunogenicity at the B- and T-cell level of nonsecreted wild-type LHBs, a secreted mutant LHBs, wild-type SHBs, and a nonsecreted mutant SHBs. Coimmunizations of mice with plasmids encoding wild-type SHBs or the secreted mutant LHBs and IL-2 increased anti-HBs responses, helper T-cell proliferative activity and cytotoxic T-lymphocyte killing. By contrast, coimmunizations of plasmids encoding wild-type LHBs or nonsecreted mutant SHBs and IL-2 had no significant effects on immune responses. Interestingly, mice immunized with cytokine expression plasmids 14 days after the injection of the wild-type LHBs plasmid showed augmented immune responses compared to animals simultaneously injected with both expression constructs. Anti-HBs responses in mice injected with plasmids encoding secreted forms of HBsAgs were detectable about 10 days earlier than those in mice immunized with plasmids encoding nonsecreted forms of HBsAgs. Based on these observations, we conclude that cytokines produced by DNA plasmids at the initial site of antigen presentation cannot augment LHBs specific immune responses because LHBs is not produced at high enough levels or is not accessible for uptake by antigen-presenting cells. (+info)
Analysis of the pre-S2 N- and O-linked glycans of the M surface protein from human hepatitis B virus. (8/2532)The surface antigen of hepatitis B virus comprises a nested set of small (S), middle (M), and large (L) proteins, all of which are partially glycosylated in their S domains. The pre-S2 domain, present only in M and L proteins, is further N-glycosylated at Asn-4 exclusively in the M protein. Since the pre-S2 N-glycan appears to play a crucial role in the secretion of viral particles, the M protein may be considered as a potential target for antiviral therapy. For characterization of the pre-S2 glycosylation, pre-S2 (glyco)peptides were released from native, patient-derived hepatitis B virus subviral particles by tryptic digestion, separated from remaining particles, purified by reversed-phase high performance liquid chromatography, and identified by amino acid and N-terminal sequence analysis as well as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Pre-S2 N-glycans were characterized by anion exchange chromatography, methylation analysis, and on target sequential exoglycosidase digestions in combination with MALDI-TOF-MS, demonstrating the presence of partially sialylated diantennary complex-type oligosaccharides. In addition, the pre-S2 domain of M protein, but not that of L protein, was found to be partially O-glycosylated by a Gal(beta1-3)GalNAcalpha-, Neu5Ac(alpha2-3)Gal(beta1-3)GalNAcalpha-, or GalNAcalpha-residue. The respective O-glycosylation site was assigned to Thr-37 by digestion with carboxypeptidases in combination with MALDI-TOF-MS and by quadrupole time-of-flight electrospray mass spectrometry. Analytical data further revealed that about 90% of M protein is N-terminally acetylated. (+info)
Serum hepatitis B surface antigen titer and transient elastography in | TCRM
Serum hepatitis B surface antigen titer and transient elastography in screening for insignificant fibrosis in HBeAg-positive chronic hepatitis B patients Ling-Bo Liang, Xia Zhu, Li-Bo Yan, Ling-Yao Du, Cong Liu, Li-Yu Chen, Juan Liao, Hong Tang Center of Infectious Disease, West China Hospital, West China School of Medicine, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Peoples Republic of China Objective: To explore the predictive value of serum hepatitis B surface antigen (HBsAg) titer and transient elastography in screening for insignificant fibrosis in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients. Methods: We conducted a cross-sectional study of eligible patients treated from March 2012 to May 2013 at the West China Hospital of Sichuan University. Eligible patients underwent liver transient elastography and liver biopsy. We assessed the serum HBsAg level, serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) level, HBV genotypes, liver stiffness
Sample Screening Protocol
Hepatitis B Surface Antigen Negative, Hepatitis B Surface Antibody Negative. Recommendation: Get immunized with the hepatitis B vaccine.. Hepatitis B Surface Antigen Negative, Hepatitis B Surface Antibody Positive. Person has antibodies to hepatitis B and is immune. Encourage him/her to have family tested.. CLIENT FOLLOW UP PROTOCOL:. You will need some sort of follow up system. Simply sending persons a letter notifying them that they are hepatitis B positive is not effective. This is one of the best areas for students to get involved because you can help develop tracking programs and follow-up with both your hepatitis B surface antigen positive and negative persons. Hepatitis B surface antigen positive persons need to see a physician even if they have no symptoms. It is ideal to follow up with everyone who participates in your screening to educate them about hepatitis B and also direct them to appropriate avenues for treatment.. Hepatitis B negative persons who also are hepatitis B surface ...
Hepatitis B virus surface antigen monoclonal antibody, clone 187 - (MAB1691) - Products - Abnova
Mouse monoclonal antibody raised against full length recombinant hepatitis B virus surface antigen. Recombinant protein corresponding to full length hepatitis B virus surface antigen. (MAB1691) - Products - Abnova
HbSAg Quantitative, Hepatitis B Surface Antigen (HbSAg) Quantitative Test Cost | Trutestlab
We offer to book Hepatitis B Surface Antigen (HbSAg) Quantitative Test online. View Hepatitis B Surface Antigen (HbSAg) Quantitative Test cost, pre test information and report availability on trutestlab.com. Home collection of blood sample is also available at our centers.
Biocard™ Hepatitis B Surface Antigen (Dip Stick) - Biocard™ Hepatitis B Surface Antigen (Dip Stick) Exporter, Manufacturer,...
TRIVITRON HEALTHCARE PVT. LTD. - Exporter, Manufacturer, Distributor & Supplier of Biocard™ Hepatitis B Surface Antigen (Dip Stick) based in New Delhi, India
Hepatitis b surface antigen | Define Hepatitis b surface antigen at Dictionary.com
Hepatitis b surface antigen definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
HKU Scholars Hub: Hepatitis B surface antigen kinetics during 10 years of virologic suppression with nucleoside analogue therapy
BACKGROUND: The kinetics of serum hepatitis B surface antigen (HBsAg) levels during long-term nucleoside analogue therapy has not been described. METHODS: We recruited 71 patients achieving persistent viro-logic suppression (Serum HBV DNA < 2,000 IU/mL) during lamivudine therapy for at least 10 years (10 patients for 15 years). Serum HBsAg (Elecsys HBsAg II) and HBV DNA levels (Cobas Taqman) were determined at baseline, year 5 and year 10. HBV genotype was determined by a line probe assay. RESULTS: The median age at lamivudine commencement was 38.6 (range 13.1 to 66.7) years. 57 patients (78.1%) were male and 43 (58.9%) were hepatitis B e antigen (HBeAg)-positive, with all 43 patients achieving HBeAg seroconversion after a median period of 2.82 (range 0.13 to 10.85) months. There was no significant difference in the median annual HBsAg decline rate from baseline to year 5 and from year 5 to 10 (0.350 and 0.359 log IU/mL/year respectively, p = 0.749). There was no difference in median annual ...
Use of pre-s protein-containing hepatitis B virus surface antigens and by J S. Yum, B C. Ahn et al.
Yum, J. S., B. C. Ahn, H. J. Jo, D. Y. Kim, K. H. Kim, H. S. Kim, Y. C. Sung, J. Yoon, J. Morrey, and H. M. Moon. 2012. Use of pre-s protein-containing hepatitis B virus surface antigens and a powerful adjuvant to develop an immune therapy for chronic hepatitis B virus infection. Clin Vaccine Immunol 19:120-127. PMID22155769. ...
Cost effective filamentous phage based immunization nanoparticles displaying a full-length hepatitis B virus surface antigen
Hepatitis B virus (HBV) is one of the major causes of chronic hepatitis, cirrhosis and liver cancer. In combating HBV infections, HBV diagnosis and vaccination are therefore critical. The hepatitis B virus surface antigen (HBsAg) is a key target molecule in developing vaccines and diagnostic systems. To date, although HBsAg has been expressed in bacteria, yeasts and mammalian cells, there are still limitations in the existing ones, which leave the necessity for searching new HBsAg production methods. In this study, a simple phage display-based method was developed to produce the purified full-length HBsAg molecules for further immunization studies. For this purpose, the HBsAg coding gene was cloned into a pCANTAB5E phagemid vector and expressed on the surface of M13 filamentous phages. The HBsAg-expressing phage nanosystem was then used as immunization agent in BALB/cJ mice. The ELISA results for sera obtained from mice immunized with HBsAg-displaying phage particles revealed an immune response ...
Hepatitis B Surface Antigen Should Not Be the Only Sought Marker to Distinguish Blood Donors towards Hepatitis B Virus...
Since its discovery by Blumberg in 1965, the hepatitis B surface antigen (HBsAg) is used as the fingerprint of hepatitis B infection. Occult hepatitis B infection (OBI) is defined by a viral replication (DNA detectable) in the absence of HBsAg. Burkina Faso is a high endemic area where the prevalence is higher than 14%. At the National Center for Blood Transfusion (NCBT) of Ouagadougou, HBsAg is the only sought marker used to distinguish donors towards Hepatitis B Virus (HBV). Acceptation of blood donation is based specifically on the absence of HBsAg, which exposes to the risk of HBV transmission during transfusion. The goal of this study is to evaluate this risk by determining the prevalence of OBI in blood donors. Patients and Methods: It was a five-month prospective study on blood donations collected from January to May 2016. The HBc antibody has been sought in the serums of negative HBsAg donors. The measure of B DNA by Real Time PCR (polymerase chain reaction) and that of antibodies
Molecular and serological detection of occult hepatitis B virus among healthy hepatitis B surface antigen-negative blood donors...
Results: Of the 1000 samples 55 (5.5%) were found to be reactive, of which 87.3% (48/55) were positive for hepatitis B surface antibody, indicating immunity as a result of previous infection however, that does not exclude active infection with escaped mutant HBV. Nested PCR results showed the presence of hepatitis B viral DNA in all the 55 samples that were positive for core protein, which is in agreement with the hepatitis B surface antibody result ...
北京大学医学部机构知识库([email protected]): Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in...
The aim of the study was to investigate correlations between intrahepatic hepatitis B virus total DNA, covalently closed circular DNA (cccDNA), and serum HBsAg in treatment-naive chronic hepatitis B and HBV related hepatocellular carcinoma (HCC). Liver tissues were taken from 42 HBV related HCC and 36 patients with chronic hepatitis B. A fraction of DNA extracted from liver tissue was digested with a plasmid-safe ATP-dependent DNase and used for HBV cccDNA detection. The remaining DNA was used for the detection of HBV total DNA and beta-globin, the latter of which is a housekeeping gene and quantified for normalization by real-time PCR. Quantitation of serum HBsAg was performed by a chemiluminescence assay. Serum HBsAg had positive correlations with serum HBV DNA (r?=?0.636, P ...
Hepatitis B Surface Antibody Anti Hbs Tests | Tennessee
Hepatitis B Surface Antibody Anti Hbs testing locations in Tennessee. You can use this list to find local Hepatitis B Surface Antibody Anti Hbs testing.
The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells...
TY - JOUR. T1 - The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells. AU - den Brouw, M.L.O.. AU - Binda, R.S.. AU - Geijtenbeek, T.B.H.. AU - Janssen, H.-G.. AU - Woltman, A.M.. PY - 2009. Y1 - 2009. U2 - 10.1016/j.virol.2009.07.015. DO - 10.1016/j.virol.2009.07.015. M3 - Article. VL - 393. SP - 84. EP - 90. JO - Virology. JF - Virology. SN - 0042-6822. IS - 1. ER - ...
Serological subtype (serotype) of hepatitis B virus surface antigen<...
TY - JOUR. T1 - Serological subtype (serotype) of hepatitis B virus surface antigen. AU - Iwasaki, Yoshiaki. AU - Tsuji, T.. PY - 1995/10. Y1 - 1995/10. UR - http://www.scopus.com/inward/record.url?scp=0029380199&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0029380199&partnerID=8YFLogxK. M3 - Article. VL - 53 Suppl. SP - 293. EP - 298. JO - Nippon rinsho. Japanese journal of clinical medicine. JF - Nippon rinsho. Japanese journal of clinical medicine. SN - 0047-1852. IS - Pt 2. ER - ...
Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen | Science
The 55 codons upstream of the gene sequence encoding the hepatitis B surface antigen (HBsAg) are called the pre-S(2) region. It has been proposed that polypeptides of high molecular weight that contain the pre-S(2) region should be included in future hepatitis B virus (HBV) vaccines. The pre-S(2) region and the S gene product [25 kilodalton (kD)] together compose a polypeptide of high molecular weight (33 kD). As an initial attempt to determine the relevance of the 33-kD polypeptide to development of an HBV vaccine, the murine immune response to pre-S(2)-encoded determinants as compared to S-encoded determinants on the same polypeptide was examined. The results indicate (i) the pre-S(2) region is significantly more immunogenic than the S region of HBsAg, (ii) the 26 amino acid residues at the NH2-terminus of the 33-kD polypeptide represent a dominant antibody binding site on the pre-S(2) region, (iii) the immune response to the pre-S(2) region is regulated by H-2-linked genes distinct from those ...
Veterans health administration hepatitis B testing and treatment with anti-CD20 antibody administration
AIM: To evaluate pretreatment hepatitis B virus (HBV) testing, vaccination, and antiviral treatment rates in Veterans Affairs patients receiving anti-CD20 Ab for quality improvement. METHODS: We performed a retrospective cohort study using a national repository of Veterans Health Administration (VHA) electronic health record data. We identified all patients receiving anti-CD20 Ab treatment (2002-2014). We ascertained patient demographics, laboratory results, HBV vaccination status (from vaccination records), pharmacy data, and vital status. The high risk period for HBV reactivation is during anti-CD20 Ab treatment and 12 mo follow up. Therefore, we analyzed those who were followed to death or for at least 12 mo after completing anti-CD20 Ab. Pretreatment serologic tests were used to categorize chronic HBV (hepatitis B surface antigen positive or HBsAg+), past HBV (HBsAg-, hepatitis B core antibody positive or HBcAb+), resolved HBV (HBsAg-, HBcAb+, hepatitis B surface antibody positive or ...
Hepatitis B Surface Antigen Should Not Be the Only Sought Marker to Distinguish Blood Donors towards Hepatitis B Virus...
Hepatitis B Surface Antigen Should Not Be the Only Sought Marker to Distinguish Blood Donors towards Hepatitis B Virus Infection in High Prevalence Area. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Hepatitis B Surface Antigen Quantity Positively Correlates with Plasma Levels of microRNAs Differentially Expressed in...
Background and AimChildren with chronic hepatitis B (CHB) are at high risk of progressive liver disease. It is suggested that a newly-identified panel of 16 microRNAs is important in the pathogenesis of CHB in children. Subviral hepatitis B surface antigen (HBsAg) particles are produced in large excess over infectious virions. Interestingly, circulating HBsAg particles have been shown to carry microRNAs. A thorough characterisation of the identified microRNAs and HBsAg over time in plasma from children with CHB may provide useful information about the natural course of childhood CHB. Patients and MethodsA cohort of 42 children with CHB was followed over time. Three to five blood samples were obtained from each child at minimum intervals of half a year; in total 180 blood samples. Plasma levels of the 16 microRNAs previously identified were analysed by quantitative real-time polymerase-chain-reaction. Plasma HBsAg was quantified using ARCHITECT® HBsAg assay. ResultsThe presence of 14/16 plasma
Hepatitis B surface antigen with Confirmation
Surface antigen usually appears in the serum after an incubation period of 1 to 6 months following exposure to Hepatitis B virus and peaks shortly after onset of symptoms. It typically disappears within 1 to 3 months. Persistence of Hepatitis B surface antigen for greater than 6 months is a prognostic indicator of chronic Hepatitis B infection. ...
Additive effect modification of hepatitis B surface antigen and e antigen on the development of hepatocellular carcinoma. |...
To assess the role of hepatitis B e antigen HBeAg and its interaction with hepatitis B surface antigen HBsAg on the development of hepatocellular carcinoma HCC, this case-control study included 361 age-and sex-matched pairs of patients with histologically proven HCC and healthy control subjects. HBsAg, HBeAg and antibody to HBeAg anti-HBe were...
Figure - Detecting Hepatitis B Surface Antigen Mutants - Volume 12, Number 2-February 2006 - Emerging Infectious Disease...
Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. HBsAg mutants present as false-negative results in some immunoassays. An understanding of immunoassay reactivity with HBsAg mutants is key to establishing an appropriate testing algorithm for hepatitis B virus detection programs.
Welcome to CDC stacks | Detecting Hepatitis B Surface Antigen Mutants - 15818 | Emerging Infectious Diseases
Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. HBsAg mutants present as false-negative results in some immunoassays. An understanding of immunoassay reactivity with HBsAg mutants is key to establishing an appropriate testing algorithm for hepatitis B virus detection programs ...
Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads. | NTU...
臺大位居世界頂尖大學之列，為永久珍藏及向國際展現本校豐碩的研究成果及學術能量，圖書館整合機構典藏（NTUR）與學術庫（AH）不同功能平台，成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of NTU Repository with Academic Hub to form NTU Scholars.. ...
The Prevalence of Hepatitis B Surface Antigen (HBsAg) and its Influencing Factors in Pregnant Women Referring to Healthcare...
Background & aim: Hepatitis B virus (HBV) infection is a major global health concern. According to the statistics, the prevalence of this infection is moderate in Iran. Pregnant mothers, who are infected with the virus (virus carriers), can transmit the infection to their fetus. This study aimed to determine the prevalence of hepatitis B surface antigen (HBsAg) and its influencing factors in pregnant women, referring to healthcare centers of Dehloran, Iran. Methods:In this descriptive, cross-sectional study, the sample consisted of all pregnant women with medical records, referring to healthcare centers of Dehloran city for prenatal care during 2011-2012. Census sampling was applied and subjects medical records were reviewed. Demographic and pregnancy-related data, and HBV test results were recorded. For data analysis, descriptive statistics, t-test and Fishers exact test were applied, using SPSS version 16.0. P-value | 0.05 was considered statistically significant. Results: In this study, the medical
Hepatitis B surface gene variants isolated from blood donors with overt and occult HBV infection in north eastern Egypt |...
Major hydrophilic region in genomic HBV extending from aa99 to aa169, clustered with a highly conformational epitope, is critical to the antigenicity of hepatitis B surface antigen (HBsAg) and may affect the diagnosis of HBV in HBV screening test. So, this study aimed to characterize variants of S gene product of hepatitis B virus (HBV) isolated from patients with overt or occult HBV infection in north-eastern Egypt. The study included sera of two different groups of volunteer blood donors (VBDs), 82 with overt HBV that were positive for HBsAg and anti-HBc and 343 donors negative for HBsAg eligible for donation. Of the latter group, only 44 were positive for anti-HBc. All anti-HBc positive sera were subjected to HBV DNA detection and partial sequence analysis targeting the HBV S gene. HBV DNA was detected in 22.7 % of HBsAg-/anti-HBc + (10/44 patients) and in 90 % of HBsAg + donors (74/82 patients) with significant statistical difference (P = 0.0001). Phylogenetic analysis showed that HBV strains
Hepatitis B Surface Antigen Testing Among Pregnant Women, United States 2014. - Semantic Scholar
BACKGROUND Post-exposure prophylaxis administered to infants shortly after birth prevents approximately 90% of cases of perinatal hepatitis B virus (HBV) transmission. The Advisory Committee on Immunization Practices recommends that all pregnant women be tested for hepatitis B surface antigen (HBsAg) at an early prenatal visit during each pregnancy to detect active infection with HBV. This study sought to determine the proportion and characteristics of pregnant women tested\not tested according to Advisory Committee on Immunization Practices recommendations. METHODS We analyzed MarketScan databases to assess prenatal HBsAg testing among women with commercial and Medicaid health care coverage according to demographic and clinical characteristics. Pregnant women 15-44 years of age continuously enrolled in a health plan in the MarketScan database during 2013 and 2014 and with a live birth in 2014 were included. RESULTS Among commercially insured women, 239,955 (87.7%) received HBsAg testing and 59.6%
Occult hepatitis B and HIV infection
Introduction Occult hepatitis B virus (HBV) infection, so-called occult B infection (OBI), is defined by the recognition of HBV-DNA in the absence of serum hepatitis B surface antigen (HBsAg). The HBV-DNA genome in OBI is fully replication competent and produced in the liver, characteristically with low-level HBV-DNA fluctuations in the bloodstream. The OBI status remains between chronic (HBsAg +) and resolved (anti-HBs +) phases in the natural history of HBV infection. Methods The clinical interest in OBI has increased because of its potential for overt HBV reactivation under immunosuppression as well as for HBV transmission, well established in recipients of blood transfusions and/or organ transplants. Results Given the shared transmission routes for HIV and HBV, earlier reports claimed that OBI was more frequent in AIDS patients. By contrast, the current scenario shows that OBI is negligible in the HIV population. One explanation is that HBV immunization and recall vaccination campaigns have ...
SID.ir | DETERMINATION OF ANTIBODY LEVELS TO HEPATITIS B SURFACE ANTIGEN (HBSAB) IN SHAHREKORD HAJAR HOSPITAL STAFFS, 2007-8
Download Free Full-Text of an article DETERMINATION OF ANTIBODY LEVELS TO HEPATITIS B SURFACE ANTIGEN (HBSAB) IN SHAHREKORD HAJAR HOSPITAL STAFFS, 2007-8
Lamivudine therapy in chronic delta hepatitis: a multicentre randomized-controlled pilot study. - Semantic Scholar
BACKGROUND Delta virus (HDV)-related chronic hepatitis is difficult to treat. AIMS To evaluate the efficacy of lamivudine 100 mg daily on serum HDV-RNA, hepatitis D virus antibodies and alanine aminotransferase levels, liver histology, and on hepatitis B surface antigen seroconversion. METHODS Thirty-one hepatitis B surface antigen-positive, HDV-RNA-positive patients with ALT | or = 1.5 upper normal level and compensated liver disease were randomized (1:2 ratio) to placebo (group A, n = 11) or lamivudine (group B, n = 20) for 52 weeks; thereafter, all patients were given lamivudine for 52 weeks and followed up for 16 weeks. RESULTS Twenty-five patients (81%) completed the study. No patient was HDV-RNA-negative at week 52; three patients (11%) were negative at week 104. Two of them remained HDV-RNA-negative at week 120, and one lost the hepatitis B surface antigen without seroconversion. Paired pre-treatment and week 104 liver biopsies were available from 19 patients: of which three of seven (43%)
A first loop linear epitope accessible on native hepatitis B surface antigen that persists in the face of second loop...
Murine monoclonal antibodies (mAbs) were raised following immunization with native mutant hepatitis B surface antigen (HBsAg) purified from human sera. A set of antibodies binding to a linear epitope carried between residues 121 and 129 of the s region was demonstrated. These antibodies were shown by cross-competition assays to bind to a single epitope whose antigenicity was influenced by the TTP motif lying between residues 125 and 127. This first loop epitope remained accessible on the surface of HBsAg in spite of major second loop mutations abrogating the normal a conformational epitopes. The mAb and its binding region in the first loop are important diagnostically and may represent an importance immunological target, one that is stable in the face of immunologically driven escape.
Proliferative responses to hepatitis B surface antigen | Open-i
Proliferative responses to hepatitis B surface antigen (HBsAg). Proliferative responses to HBsAg, measured as counts per minute (cpm) of 3H-thymidine incorporat
The prevalence of hepatitis B surface antigen and its antibody in blood donors and high risk groups in Iran - Request PDF
Farzadegan, H.; Harbour, C.; Ala, F., 1979: The prevalence of hepatitis B surface antigen and its antibody in blood donors and high risk groups in Iran
Gentaur Molecular :AbD \ GOAT ANTI HEPATITIS B SURFACE ANTIGEN AD AY HRP-POLYCLONAL ANTIBODY \ 4940-1484
Gentaur molecular products has all kinds of products like :search , AbD \ GOAT ANTI HEPATITIS B SURFACE ANTIGEN AD_AY HRP-POLYCLONAL ANTIBODY \ 4940-1484 for more molecular products just contact us
Hepatitis B Surface Antigen Test | STD Testing | AMH Nationwide
AMH Nationwide offers Hepatitis B Surface Antigen tests at their facilities. Call us at ☎ (888) 493-2521 to find more information about a lab near you!
Hepatitis B surface antigen is not associated with chronic renal disease in Aboriginal Australians [letter] « Bibliography «...
The details of bibliography - Hepatitis B surface antigen is not associated with chronic renal disease in Aboriginal Australians [letter]
Appendix C: Identification and Management of Hepatitis B Surface Antigen (HBsAg)--Positive Persons
Persons with chronic hepatitis B virus (HBV) infection are at high risk for chronic liver disease and are a major reservoir of HBV infection. Foreign-born populations from Africa, Asia, and the Pacific Islands have high rates of chronic HBV infection (i.e., HBsAg prevalence of ,8%). During delivery of recommended hepatitis B vaccination services (e.g., HBsAg screening of pregnant women and serologic testing to assess susceptibility), vaccination providers will identify persons who are HBsAg positive. These persons require counseling and medical management for chronic HBV infection to reduce their risk for chronic liver disease. Their susceptible household, sex, and needle-sharing contacts also should be vaccinated against hepatitis B. Extending screening, referral, and contact vaccination services to persons identified as HBsAg positive can help prevent serious sequelae in persons with chronic infection and enhance vaccination strategies to eliminate HBV transmission. This appendix provides ...
Recombinant Hepatitis B Surface Antigen ad | Bio-Rad Antibodies (formerly AbD Serotec)
Bio-Rad Antibodies (formerly AbD Serotec) is the research antibody division of Bio-Rad, the worlds leading life science company.
Hepatitis B Surface Antibody, Qualitative.
The detection of anti-HBs is indicative of a prior immunologic exposure to the antigen or vaccine. To determine immune status as ≥10 mIU/mL as per CDC guidelines, please order Hepatitis B Surface Antibody, Quantitative.. ...
Infectious Screening Panel Details | Your on-demand digital laboratory tests platform for on-the-go access to value-based...
Screening is the process of identifying people who appear healthy but may be at increased risk of a disease or condition. Most often, the timing of the infection is a critical point for infectious disease screening, as a failure of early detection and timely intervention is a missed opportunity for prompt treatment and prevention.. Our Screening panel includes Hepatitis B surface antigen (HBsAg), Hepatitis C Virus (HCV), Retroviral screening (RVS), H.Pylori, Typhoid (Widal), Stool microscopy, and Urine microscopy.. Hepatitis B surface antigen (HBsAg): With the increasing number of hepatitis B infection, unknown to many who are being infected with the virus, the need for Hepatitis B surface antigen (HBsAg) remains strong. The test is targeted to check the presence of Hepatitis B Virus (HBV) in the blood.. Hepatitis C Virus (HCV) antibody test: HCV is transmitted in a manner similar to HBV. Most cases of hepatitis C are caused by blood transfusion. HCV is found in as many as 8% of blood donors ...
Hepatitis B Surface Antibody Anti Hbs Testing in Bel Air, Maryland
Hepatitis B Surface Antibody Anti Hbs testing in Bel Air, Maryland. Find a lab near you and save when you get blood work directly through Personalabs!
Anti-Hepatitis B Virus Surface Antigen antibody [HB12] (ab2039)
Mouse monoclonal Hepatitis B Virus Surface Antigen antibody [HB12] validated for ELISA. Immunogen corresponding to recombinant full length protein
Anti-Hepatitis B Virus Surface Antigen抗体[HB3] (ab8256)
Hepatitis B Virus Surface Antigen小鼠单克隆抗体经ELISA, ICC实验严格验证。所有产品均提供质保服务，中国75%以上现货。
CDIA™ Hepatitis B Surface Antibody Test Kit - Creative Diagnostics
The HBsAb Rapid Test Is,direct Binding Test For The Visual Detection Of Antibodies To Hepatitis B Surface Antigen (Anti-HBs) In Serum/plasma. It Is Used As An Aid In The Diagnosis Of Hepatitis B Inf...
Hepatitis B surface antigen (HBsAg) in the liver of patients with hepatitis; a comparison with serological detection. | Journal...
Chronic hepatitis was diagnosed on liver biopsy of 76 patients; 52 (68%)had HBsAg. Of the 52 patients with HBsAg, 23% had HBsAg shown by immunofluorescence on the liver, while it could not be detected with radioimmunoassay on the serum; 77% had HBsAg detectable in liver and in serum, and none had HBsAg in serum only. HBsAg was detected more frequently in chronic aggressive hepatitis and active cirrhosis than in chronic persistent hepatitis and cirrhosis with little activity. No correlation was found in the different forms of chronic hepatitis between the HBsAg status on the one hand, and levels of transaminases, gammaglobulins, and auto-antibodies on the other. Acute hepatitis was diagnosed on liver biopsy of 24 patients; 50% had HBsAg. Liver tissue positivity was very low in the fully developed stage compared to serum positivity. In 146 patients with other liver ailments, both liver and serum were negative for HBsAg.. ...
Hydrogel-Delivered GM-CSF Overcomes Nonresponsiveness to Hepatitis B Vaccine through the Recruitment and Activation of...
The standard hepatitis B surface Ag (HBsAg) vaccine fails to induce anti-hepatitis B surface Abs in 5-10% of healthy subjects, a phenomenon known as HBsAg nonresponsiveness, which is closely related to HLA class II alleles and impaired Th cell responses to HBsAg in these subjects. We hypothesized that GM-CSF, a potent adjuvant in enhancing the Ag-presentation activity of APCs, might help to generate Th cell responses in nonresponders, subsequently providing help for B cells to produce anti-hepatitis B surface Abs. We used a thermosensitive biodegradable copolymer (hydrogel) system to codeliver HBsAg and GM-CSF to achieve maximal local cytokine activity at the injection site. In responder mouse strains, hydrogel-formulated HBsAg plus GM-CSF (Gel/HBs+GM) vaccine elicited much greater anti-hepatitis B surface Ab titers and Th cell proliferative responses than a commercial aluminum-formulated HBsAg vaccine or free HBsAg. The adjuvant effect of the Gel/HBs+GM vaccine was dependent upon the local ...
Anti-Hepatitis B Virus Surface Antigen antibody [HB6] (HRP) (ab2042) References
References for Abcams Anti-Hepatitis B Virus Surface Antigen antibody [HB6] (HRP) (ab2042). Please let us know if you have used this product in your…
Hepatitis B Annual (HBA)
Aim: To evaluate the occurrence of Hepatitis B surface antigen positivity in family members of HBsAg-positive patients, to assess the profile of HBV infection in them, to identify possible risk factors in a close family environment, and to evaluate the burden of liver disease in these family members. Materials and Methods: All Hepatitis B surface antigen-positive patients who attended the Liver Clinic of the Gastroenterology Department of the Calicut Medical College, from January 2009 to December 2010, were studied. The index case was evaluated with HBeAg, anti HBeAb, HBV DNA, liver function tests (LFTs), ultrasonogram of the abdomen, and alpha fetoprotein, as also liver biopsy in indicated cases. The index patient was interviewed and a detailed history with special emphasis on probable risk factors was taken. All first-degree relatives and relatives staying in the same house of the index case were screened for HBsAg. The relatives who tested negative for the infection were advised HBV ...
Expression of hepatocyte hepatitis B core antigen and hepatitis B surface antigen as a marker in the management of chronic...
TY - JOUR. T1 - Expression of hepatocyte hepatitis B core antigen and hepatitis B surface antigen as a marker in the management of chronic hepatitis B patients. AU - Yim, Sun Young. AU - Kim, Tae Hyung. AU - Jun, Suh Sang. AU - Kim, Eun Sun. AU - Keum, Bora. AU - Seo, Yeon Seok. AU - Yim, Hyung Joon. AU - Jeen, Yoon Tae. AU - Chun, Hoon Jai. AU - Lee, Hong Sik. AU - Um, Soon Ho. AU - Kim, Chang Duck. AU - Won, Nam Hee. AU - Ryu, Ho Sang. N1 - Funding Information: This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020).. PY - 2017/5. Y1 - 2017/5. N2 - Background/Aims: We aimed to clarify the association of hepatitis B surface antigen (HBsAg)/hepatitis B core antigen (HBcAg) with the disease status and treatment response in patients with chronic hepatitis B (CHB). Methods: We investigated 171 biopsy-proven entecavir-treated CHB patients (109 hepatitis B e antigen [HBeAg]-positive, 62 HBeAg-negative). HBcAg ...
The importance of the serum quantitative levels of hepatitis B surface antigen and hepatitis B e antigen in children with...
Hepatitis B surface antigen, hepatitis B e antigen, hepatitis B virus DNA, alanine aminotransferase, liver histology, quantification
Response-guided peginterferon therapy in hepatitis B e antigen-positive chronic hepatitis B using serum hepatitis B surface...
On-treatment levels of hepatitis B surface antigen (HBsAg) may predict response to peginterferon (PEG-IFN) therapy in chronic hepatitis B (CHB), but previously proposed prediction rules have shown limited external validity. We analyzed 803 HBeAg-positive patients treated with PEG-IFN in three global studies with available HBsAg measurements. A stopping-rule based on absence of a decline from baseline was compared to a prediction-rule that uses HBsAg levels of ,1,500 IU/mL and ,20,000 IU/mL to identify patients with high and low probabilities of response. Patients with an HBsAg level ,1,500 IU/mL at week 12 achieved response (HBeAg loss with HBV DNA ,2,000 IU/mL at 6 months posttreatment) in 45%. At week 12, patients without a decline in HBsAg achieved a response in 14%, compared to only 6% of patients with HBsAg ,20,000 IU/mL, but performance varied across HBV genotype. In patients treated with PEG-IFN monotherapy (n = 465), response rates were low in patients with genotypes A or D if there was ...
Telbivudine Versus Entecavir in Reducing Serum HBsAg Levels in Patients With HBeAg-positive Chronic Hepatitis B - Tabular View ...
The goal of chronic hepatitis B (CHB) treatment is complete and permanent eradication of hepatitis B virus (HBV) from patients body, which is best represented by serum HBsAg loss accompanied by undetectable serum HBV DNA level.. While the most recently approved nucleos(t)ide analogues (NA) have marked antiviral potency and can induce HBV DNA undetectability in the majority of patients through prolonged treatment, NA need to be given long term, almost indefinitely, in most cases because they suppress HBV DNA only during therapy. For example, even after HBeAg-loss by a potent NA, suppression of serum HBV DNA to undetectable level is sustained only in about 23%-37% at 24 weeks off treatment. Thus, continuous therapy with NA until HBsAg clearance remains necessary in a majority of cases.. The recent availability of commercial quantitative assays of serum hepatitis B surface antigen (HBsAg) has enabled quantitative HBsAg to be used as a biomarker for prognosis and treatment response in CHB. It has ...
Hepatitis B Surface Antigen(HBsAg) Loss in Chronic Hepatitis B Patients With Low Viral Load - Full Text View - ClinicalTrials...
Rationale:. Worldwide, approximately 400 million people are chronically infected with hepatitis B virus (HBV). Chronic HBV infection increases the risk of developing cirrhosis, hepatic decompensation and hepatocellular carcinoma (HCC). The risk of developing hepatocellular carcinoma is highest in HBeAg positive patients with high HBV DNA levels, but still the relative risk remains 10 for HBeAg negative patients. Furthermore it has been shown that when HBsAg is cleared before cirrhosis has developed, the prognosis is excellent. Recently the investigators have shown that HBeAg negative patients with high HBV-DNA load and low baseline HBsAg levels had a significantly higher HBsAg clearance (positive predictive value of 85%) after combination therapy with peginterferon alfa2a (Peg-IFN) and adefovir.. Based on these results, a trial was designed to investigate whether combination of a nucleos(t)ide analogue combined with PegIFN, could also provoke a high rate of HBsAg clearance in chronic hepatitis B ...
Journal of AIDS and HIV Research - human immunodeficiency virus and hepatitis b virus (hiv/hbv) co-infection in people living...
Co-infection with HIV and hepatitis B virus (HBV) has become an important factor of co-morbidity and mortality. The aim of this study was to determine the seroprevalence of HIV/HBV co-infection and its effect on the disease progression in people living with HIV/AIDS identified in Yaoundé Central Hospital. Blood samples from 75 HIV positive patients were collected in Yaoundé Central Hospital from November 2015 to February 2016, for the determination of hepatitis B virus surface antigen (HBsAg) using immunoassays. Cluster of differentiation 4 (CD4) T-cells count and biochemical markers of liver function were also collected and analyzed. The socio-demographic data were also collected. The effect sizes were confirmed using G*Power version 188.8.131.52 software. The data were entered and analyzed using the SPSS Version 22.1 software. The statistical tests performed were x2, and Pearson correlation, with significant difference at the threshold p ≤ 0.05. Hepatitis B virus surface antigen
Nucleic acid polymers reduce HBsAg levels and improve control of hepatitis B virus | World Hepatitis Alliance
The nucleic acid polymers REP 2139 and REP 2165 led to hepatitis B surface antigen (HBsAg) reduction or clearance when combined with tenofovir and pegylated interferon, according to early results from a small study presented as a late-breaker at the 2016 AASLD Liver Meeting this month in Boston. This combination may potentially enable functional control of hepatitis B if confirmed in larger studies.. Over years or decades chronic hepatitis B virus (HBV) infection can lead to advanced liver disease including cirrhosis and liver cancer. Antiviral therapy using nucleoside/nucleotide analogues such as entecavir (Baraclude) or tenofovir disoproxil fumarate (Viread) is the mainstay of treatment for chronic hepatitis B. While these drugs can suppress HBV replication during therapy, and can thereby reduce the risk of liver disease progression, they usually do not lead to a cure - as indicated by HBsAg loss and anti-HBs antibody seroconversion - and long-term treatment is generally needed. Researchers ...
IHC Double Stain for Hepatitis B Surface Antigen (HBsAg) and Hepatitis B Core Antigen (HBcAg) - LabCE.com, Laboratory...
New double staining technology allows for easier staining protocols and faster turnaround time. The cocktail approach can be used when two primary antibodies are from different host species, as is the example of these two antibodies (mouse monoclonal antibody against HBsAg and rabbit polyclonal antibody against HBcAg). A secondary antibody or detection system can also be a cocktail of horseradish peroxidase (HRP) labeled anti-rabbit and alkaline phosphatase (AP) labeled anti-mouse. This allows simultaneous incubation of both primary antibodies, followed by simultaneous incubation of the cocktailed secondary detection reagents. This is a huge time saver compared to sequential staining techniques. The only sequential step in the cocktail approach is the application of DAB chromogen followed by application of fast red (FR) chromogen ...
Hepatitis B Core Antigen (HBcAg) and Hepatitis B Surface Antigen (HBsAg) Double Stain in Liver. - LabCE.com, Laboratory...
The page below is a sample from the LabCE course Liver Biopsies: Anatomy and Histological Considerations. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online ...
Products - ELISA Hepatitis - Farminpex N.V. - Medical Equipment Curaçao
Hepatitis A. HAV Ab. Competitive Enzyme ImmunoAssay (ELISA) for the determination of antibodies to Hepatitis A Virus in human plasma and sera.. HAV IgM. Enzyme ImmunoAssay (ELISA) for the determination of IgM class antibodies to Hepatitis A Virus in human plasma and sera.... Hepatitis B. HBc Ab. Competitive Enzyme ImmunoAssay (ELISA) for the determination of antibodies to Hepatitis B core Antigen in human plasma and sera.. HBc IgM. Enzyme ImmunoAssay (ELISA) for both the quantitative and qualitative determination of antibodies.... HBe Ag/Ab. Enzyme ImmunoAssay (ELISA) for the determination of Hepatitis B Virus \e\ Antigen and Antibody in human plasma and sera.. HBs Ab. Enzyme ImmunoAssay (ELISA) for both the quantitative and qualitative determination of antibodies.... HBs Ag. Third generation Enzyme Immunoassay for the determination of Hepatitis B surface Antigen or HBsAg in human serum and plasma.. HBs Ag Conf.. Third generation Enzyme Immunoassay for the determination of Hepatitis B surface ...
Evaluation of Aspergillus niger as host for virus-like particle production, using the hepatitis B surface antigen as a model
The filamentous fungus Aspergillus niger was transformed with the hepatitis B virus S gene encoding the major viral envelope protein under control of the constitutive A. nidulans glyceraldehyde-3-phosphate dehydrogenase (gpdA) promoter. Approximately seven copies of the expression cassette were integrated on the genome, resulting in high-level transcription of the S gene. Production of the 24-kDa S protein and a 48-kDa S protein dimer in the membrane-associated protein fraction of the recombinant A. niger strain was shown through Western analysis. Electron microscopy of partially purified recombinant S protein revealed the formation of spherical pseudoviral particles with a diameter of 22 nm. The production level of hepatitis B pseudoviral particles was estimated to be 0.4 mg/1 culture, which compares favourably with the reported levels initially obtained in yeast, indicating the potential of the Aspergillus expression system as an alternative, cost-effective vaccine production system.. ...
Hep B surface antigen positive - Hepatitis B - MedHelp
I am diagnosed as Hep B carrier.My test reports:HbS antigen. positive. hep e antigen.Negative.HBV DNA.Negative.I am on treatment with lumividine tab 100 mg/day for about 3 yrs.My ALT level & liver ult...
Hepatitis B Immune Globulin: Some Progress and Some Problems | Annals of Internal Medicine | American College of Physicians
The discovery at the end of the 1960s that the Australia antigen (now called hepatitis B surface antigen [HBsAg]) is a component of hepatitis B virus (HBV) opened the door to preparation of hepatitis B immune globulin (HBIG) having titers of specific antibody (anti-HBs) many hundredfold times higher than those in standard immune serum globulin (ISG). As rapidly as anti-HBs-rich units of plasma could be identified and batches of HBIG prepared, studies of prophylaxis of type B hepatitis were carried out (1-6). Unfortunately, these investigations did not provide an easily interpretable answer to relative usefulness of HBIG and ISG. Hence, ...
Hepatitis B surface antigen prevalence among 12 393 rural women of childbearing age in Hainan Province, China: a cross...
Hepatitis B has been a serious public health problem in Hainan for a long time. In 1992, the Chinese national HBV seroprevalence survey found that the HBsAg seroprevalence of the population in Hainan was 16.54%, ranking first in China . The seroprevalence level of HBsAg of 9.51% in this study of the childbearing age women in Hainan is higher than the 7.18% found among the overall population of China ; it is also higher than those women of childbearing age in Jiangsu province, China (6.71%) , pregnant women in Catalonia, Spain (1.2%)  and in Greece (1.16%) ; but lower than women of childbearing age in Madagascar (13.6%) . Overall, the high positive rate of HBsAg among rural women of childbearing age in Hainan highlights the need for public health workers and government to come up with preventive measures of reducing the prevalence of HBsAg among women of childbearing age.. This study showed that HBsAg carrier rate was significantly related with age of the rural women. The ...
Gilead Announces Scientific Presentations Demonstrating Efficacy of Harvoni® (Ledipasvir/Sofosbuvir) in Special Patient...
The global prevalence of HCV/HBV co-infection is estimated to be 1.7-3.9 million. Reactivation of HBV infection during treatment of HCV infection with direct-acting antiviral agents has been reported in the postmarketing setting. However, clinical trials to more systematically assess the safety and efficacy of direct-acting antiviral therapy in HCV/HBV co-infected patients with active HBV infection have not been conducted. This Phase 2, open-label study led by Chun-Jen Liu, Professor of Medicine at National Taiwan University in Taipei, Taiwan, evaluated 12 weeks of Harvoni in 111 genotype 1 or 2 HCV-infected patients in Taiwan with active HBV co-infection (hepatitis B surface antigen positive), who were not receiving HBV treatment. All patients achieved SVR12 (100 percent, 111/111) including 68 genotype 1 HCV-infected patients, 43 genotype 2 HCV-infected patients, 17 patients with compensated cirrhosis and 37 with prior HCV treatment failure. Three patients had serious adverse events that were ...
Hepatitis B Virus s Antigen (HBsAg) AlphaLISA Detection Kit, 500 assay points | PerkinElmer
Detect and quantitate Hepatitis B Virus Surface antigen (HBsAg) in buffer and cell culture media using a homogeneous AlphaLISA no-wash assay.
Hepatitis B-DNA replication and histological patterns in liver biopsy specimens of chronic HBsAg positive patients with and...
The role of active hepatitis B virus (HBV) infection in chronic HBsAg positive hepatitis with and without hepatitis delta virus (HDV) superinfection was analysed in percutaneous liver biopsy specimens from 50 patients. Each specimen was divided into two--one part for histological evaluation and for the detection of HBcAg and delta antigen; the other part was tested for HBV-DNA using Southern blotting. Ten cases were of chronic lobular hepatitis, 10 of chronic persistent hepatitis, and 30 of chronic active hepatitis. Ten cases were delta antigen positive and showed high grade lobular activity but no evidence of HBV-DNA episomal forms or HBcAg reactivity. Twenty one cases showed HBV-DNA replicative intermediate forms; 19 had high grade lobular activity, which occurred in five cases without evidence of free viral DNA. Of the 21 biopsy specimens with HBV-DNA episomal forms, 14 were positive for HBcAg; only one of the 19 cases without detectable viral DNA was positive for such antigen. These data ...
Hepatitis | Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e | AccessPediatrics | McGraw-Hill...
anti-HAV, antibody to HAV (IgM and IgG subclasses); anti-HAV-IgG, IgG class antibody to HAV; anti-HAV-IgM, IgM class antibody to HAV; anti-HBc, antibody to HBcAg; anti-HBc-IgG, IgG class antibody to HBcAg; anti-HBc-IgM, IGM class antibody to HBcAg; anti-HBe, antibody to HBeAg; anti-HBs, antibody to HBsAg; anti-HCV, antibody to hepatitis C; HBeAg, hepatitis B e antigen; HBcAg, hepatitis B core antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HCV, hepatitis C virus; IgM and IgG, immunoglobulins M and G. ...
Translocation and accumulation of exogeneous hepatitis B virus preS surface proteins in the cell nucleus | Journal of Cell...
Recurrent reports about protease-sensitive sites in the junction of the preS and S region of the hepatitis B virus large surface protein have raised the question about a possible biological role of S protein-depleted, independent preS protein fragments in the virus life cycle. In the present study, this question was addressed by exogenous introduction of fluorescence-labeled recombinant preS proteins into permeabilized HepG2 cells. While maltose-binding proteins (MBP) were evenly distributed throughout the cytoplasm, MBP-preS fusion proteins selectively accumulated in the nucleus. Using truncated preS proteins, the effective domain for this nuclear accumulation was localized around the preS2 region. The mode of this action differs from conventional nuclear translocation mechanism in its energy- and mediator-independency and in that it is not saturated regardless of the increase of preS protein concentration. The biological meaning of this phenomenon has to be further studied. However, in regard ...
Detection of HBV DNA in HBsAg Negative Normal Blood Donors
Background: The risk of infection by transfusion-transmitted viruses has been reduced remarkably. However, a zero-risk blood supply is still desirable. The screening for antibody to HBc (anti-HBc) has been shown as an alternative test for the detection of HBV infection. Objective: The main aim of this study was to evaluate HBV infection markers and the potential value of anti-HBc testing of blood donors to detect HBV infection. Methods: In this descriptive cross-sectional study, 545 blood samples were collected and tested for HbsAg using ELISA method. Then all HBsAg negative samples were tested for anti-HBc by the same method. To detect HBV infection, all HBsAg negative and anti-HBc positive samples were tested by PCR for HBV DNA. Results: All blood samples were HBsAg negative of which, 43 (8%) were anti-HBc positive. From those which were positive for anti-HBc, five samples were also positive for HBV DNA. Conclusion: Occult HBV infection is a clinical form of HBV infection in which HBsAg is not
Two core promotor mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced...
TY - JOUR. T1 - Two core promotor mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication. AU - Baumert, Thomas F.. AU - Rogers, Steven A.. AU - Hasegawa, Kiyoshi. AU - Liang, T. Jake. PY - 1996/11/15. Y1 - 1996/11/15. N2 - Viral mutations have been implicated in alteration of the biological phenotype of hepatitis B virus (HBV). We recently cloned and sequenced the viral genome of an HBV strain associated with an outbreak of fulminant hepatitis (FH strain). The FH strain contained numerous mutations in all genomic regions and was functionally characterized by a more efficient encapsidation of pregenomic RNA leading to highly enhanced replication. To define the responsible mutation(s) for the enhanced replication, we introduced individual mutations of the FH strain into a wild-type construct by oligonucleotide-directed mutagenesis. Analysis of viral replication showed that two adjacent mutations in the HBV core promotor (C to T ...
JCI - Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e...
T cell proliferative responses to hepatitis B virus-encoded envelope antigen (S + preS2 + preS1), recombinant core antigen (HBcAg), and natural hepatitis B e antigen (HBeAg) were examined in 22 HBeAg-positive patients with chronic type B hepatitis and 17 healthy hepatitis B surface antigen (HBsAg) carriers. The results showed that HBeAg-positive patients had (a) higher levels of T cell responses to HBcAg/HBeAg than those of healthy HBsAg carriers (P less than 0.001 and P less than 0.01, respectively); (b) a further increase in these T cell responses during acute exacerbations (P less than 0.05 and P less than 0.05, respectively); (c) subsidence in the T cell responses to HBcAg/HBeAg after recovery from acute exacerbations and HBeAg seroconversion, whereas the responses would persist at high levels if the patients did not enter a clinical remission; and (d) low levels of T cell responses to S + preS2 + preS1 either before or after HBeAg seroconversion. The appearance of increasing T cell ...
Sparrho | Prevention of hepatitis B virus infection from hepatitis B
Hepatic grafts from hepatitis B surface antigen-negative and anti-core antibody (HBcAb)-positive donors have been shown to transmit hepatitis B virus (HBV) infe
Trends in prevalence of HIV infection, hepatitis B and hepatitis C among Australian prisoners - 2004, 2007, 2010
Objective: To report the prevalence of markers for HIV infection, hepatitis B and hepatitis C among Australian prison entrants. Design: Cross-sectional survey conducted over 2-week periods in 2004, 2007 and 2010. Setting: Reception prisons in New South Wales, Queensland, Tasmania and Western Australia. Participants: Individuals entering prison from the community during the survey periods. Main outcome measure: Prevalence of anti-HIV antibody (anti-HIV), hepatitis B surface antigen (HBsAg), anti-hepatitis B core antibody (anti-HBc) and anti-hepatitis C virus antibody (anti-HCV). Results: The study included 1742 prison entrants: 588 (33.8%) in 2004, 536 (30.8%) in 2007 and 618 (35.5%) in 2010. The age-standardised prevalence estimates for anti-HIV, HBsAg and anti-HBc were 0.4%, 2.3% and 21.7% respectively, and remained stable over the three survey periods. The age-standardised prevalence estimate for anti-HCV was 29.0%; it decreased over time (33.3% in 2004 v 23.2% in 2010; P = 0.001), and this ...
Advisory Committee on Immunization Practices (ACIP) Recommended Immunization Schedule for Persons Aged 0 Through 18 Years -...
1. Hepatitis B (HepB) vaccine. (Minimum age: birth). Routine vaccination: At birth. • Administer monovalent HepB vaccine to all newborns before hospital discharge.. • For infants born to hepatitis B surface antigen (HBsAg)-positive mothers, administer HepB vaccine and 0.5 mL of hepatitis B immune globulin (HBIG) within 12 hours of birth. These infants should be tested for HBsAg and antibody to HBsAg (anti-HBs) 1 to 2 months after completion of the HepB series, at age 9 through 18 months (preferably at the next well-child visit).. • If mothers HBsAg status is unknown, within 12 hours of birth administer HepB vaccine to all infants regardless of birth weight. For infants weighing ,2,000 grams, administer HBIG in addition to HepB within 12 hours of birth. Determine mothers HBsAg status as soon as possible and, if she is HBsAg-positive, also administer HBIG for infants weighing ≥2,000 grams (no later than age 1 week).. Doses following the birth dose. • The second dose should be ...
Hepatitis B Virus Surface Ad/Ay Antibody
Hepatitis B Virus Surface Ad/Ay Polyclonal Antibody from Invitrogen for ELISA applications. This antibody reacts with Virus samples. Supplied as 1 mL purified antibody (4-5 mg/ml) in PBS with 0.1% sodium azide.
Hepatitis B Virus Surface Antigenwith Reflex to Confirmation
Hepatitis B Virus Surface Antigenwith Reflex to Confirmation,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
High rates of active hepatitis B and C co-infections in HIV-1 infected Cameroonian adults initiating antiretroviral therapy
OBJECTIVES: To investigate the presence of hepatitis B virus (HBV) DNA and hepatitis C virus (HCV) RNA in HIV-infected patients initiating antiretroviral therapy in Cameroon. METHODS: Baseline blood samples from 169 patients were tested retrospectively for hepatitis B surface antigens (HBsAg), anti-hepatitis B core (anti-HBc), anti-HCV and - if HBsAg or anti-HCV result was positive or indeterminate - for HBV DNA or HCV RNA, respectively, using the Cobas Ampliprep/Cobas TaqMan quantitative assay (Roche Diagnostics GmbH, Mannheim, Germany). RESULTS: HBV DNA was detected in 14 of the 18 patients with positive or indeterminate HBsAg results [8.3% of the total study population, 95% confidence interval (CI) 4.6-13.5]. The median HBV viral load was 2.47 x 10(7) IU/mL [interquartile range (IQR) 3680-1.59 x 10(8); range 270 to ,2.2 x 10(8)]. Twenty-one patients (12.4%, 95% CI 7.9-18.4) were found with HCV RNA (all with positive HCV serology). The median HCV viral load was 928 000 IU/mL (IQR 178 400-2.06 ...
Significance of blood-related high-risk behaviors and horizontal transmission of hepatitis B Virus in Iran - Repository of...
Hepatitis B virus (HBV) is a significant public health problem and a leading cause of morbidity and mortality, and approximately 30 of the worlds population is infected with HBV. The objective of our study was to determine the seroprevalence of HBV and major risk factors associated with its occurrence. Four thousand eighty-seven healthy Iranian subjects aged 8-80 years were screened for HBV serological markers by an enzyme immunoassay method. A structured questionnaire was administered to all participants. Multiple logistic regression, an unpaired t-test for continuous data and the χ2 test for categorical data were performed. A total of 4087 participants were tested for hepatitis B surface antigen (HBsAg), of which 62 (1.5) were seropositive. Fifteen percent of the subjects were positive for anti-HBs, 6.3 were positive for isolated anti-HBc and 12.5 were positive for both anti-HBs and anti-HBc. Laborers showed a higher HBsAg+ seroprevalence and risk compared with jobless participants ...
Everything Murphy...: Blessings from Minnesota
Thanks for sending Chuan Qians records for review. Hes a lovely little boy who appears to be doing reasonably well.. His growth is marginal for his given age. however, since they estimated his birthday and we dont know his birthweight or gestational age, his growth could be completely appropriate for his actual age. His update in November puts him slightly below or at the lower limits of normal. Im reasonably certain that hell catch up nicely when he reaches your home and grow within the normal range. His lab tests showed a weakly positive hepatitis B surface antibody which may be due to his immunizations. He also had a weakly positive hepatitis B e antibody which could either be a false positive or be antibody transferred from his birth mother prior to birth. The most important test was the hepatitis B surface antigen which was negative so he doesnt have hepatitis B. He also tested negative for HIV and syphilis. His development is close to being normal for his given age. Again, it may be ...
Prevalence of human immunodeficiency virus and hepatitis B virus infections in young women seeking abortion care in Ethiopia: a...
Young women aged 15-24 years are members of key populations at higher risk for Human Immunodeficiency Virus (HIV) acquisition through sexual intercourse. In areas where unprotected sex is a common practice, Hepatitis B virus (HBV) commonly transmitted via sexual and parenteral routes. The study aimed at determining HIV and HBV infections prevalence in young women attending health institutions for abortion care in Bahir Dar city, Ethiopia. A cross - sectional study was conducted from January 2015 to June 2015. Convenient sampling technique was used. Demographic and explanatory variables were collected using a structured questionnaire via face to face interview. The presence of antibody to HIV infection was detected using national HIV diagnostic test algorithm. Hepatitis B surface antigen (HBsAg) was detected using ELISA. Data were analyzed using descriptive, fishers exact and independent sample T test as appropriate. A total of 360 young women aged 15-24 years participated in the study. The median age
Sabinet | Human immunodeficiency virus and hepatitis B or C co-infection in KwaZulu-Natal : a retrospective analysis of a...
Hepatitis B or C virus infection has an important influence on treatment and outcomes in human immunodeficiency virus (HIV)-infected individuals. HIV worsens the prognosis in hepatitis B- or C virus-infected patients, and patients on antiretroviral therapy are more likely to experience hepatotoxicity if they are co-infected with a hepatotropic virus. There is a paucity of data on the epidemiology of hepatotropic viruses in relation to each other and to HIV in KwaZulu-Natal. The aim of this study was to describe the seroprevalence of hepatitis B and C virus in HIV-positive and -negative individuals in KwaZulu-Natal from 2002-2010, using a large laboratory database of routine serological results. Patients who had an HIV or hepatitis B or C test performed at the National Health Laboratory Service Department of Virology in Durban from 2002-2010 were included in the study. The study revealed that the overall seropositivity of hepatitis B surface antigen (HBsAg) was 12.05%, and that of hepatitis C
Hepatitis B virus strains of subgenotype A2 with an identical sequence spreading rapidly from the capital region to all over...
Hepatitis B virus strains of subgenotype A2 with an identical sequence spreading rapidly from the capital region to all over Japan in patients with acute hepatitis B ...
undetectable viral load
For people who have been diagnosed with chronic hepatitis B and delta coinfection, a low or undetectable hepatitis B viral load does not usually indicate that theyve cleared both infections. This is because, in cases of coinfection, hepatitis delta usually becomes the dominant virus, and suppresses hepatitis B, slowing or even stopping its replication entirely. If someone is still positive for the hepatitis B surface antigen (HBsAg), the hepatitis delta virus can still replicate (often with copies in the millions) and cause potential liver damage 1. For this reason, the test to measure hepatitis delta activity, the HDV RNA test, is important in disease monitoring and management 2,3. Available since 2013, the HDV RNA test can be acquired internationally through the Centers for Disease Control and Prevention (CDC), and from several labs in the US. For those suspected of having acute hepatitis B and delta coinfection, HBsAg testing should follow 6 months after initial diagnosis. If HBsAg is ...
Prevalence of hepatitis B and C infection in persons living with HIV enrolled in care in Rwanda - edoc
Hepatitis B (HBV) and C (HCV) are important causes of morbidity and mortality in people living with human immunodeficiency virus (HIV). The burden of these co-infections in sub-Saharan Africa is still unclear. We estimated the prevalence of the hepatitis B surface antigen (HBsAg) and hepatitis C antibody (HCVAb) among HIV-infected individuals in Rwanda and identified factors associated with infection.; Between January 2016 and June 2016, we performed systematic screening for HBsAg and HCVAb among HIV-positive individuals enrolled at public and private HIV facilities across Rwanda. Results were analyzed to determine marker prevalence and variability by demographic factors.; Overall, among 117,258 individuals tested, the prevalence of HBsAg and HCVAb was 4.3% (95% confidence interval [CI] (4.2-4.4) and 4.6% (95% CI 4.5-4.7) respectively; 182 (0.2%) HIV+ individuals were co-infected with HBsAg and HCVAb. Prevalence was higher in males (HBsAg, 5.4% [5.1-5.6] vs. 3.7% [3.5-3.8]; HCVAb, 5.0% [4.8-5.2] ...
July | 2021 | PPAR Signal.com
In sub-Saharan Africa, the viral marker burden in blood donor populations ranges between 10 and 30 percent. Sapitinib mw Deferred donors constitute a rare population of asymptomatic human immunodeficiency virus (HIV)- and hepatitis B virus (HBV)-infected individuals with high likelihood of long survival if cared for. Deferred donor care provides an opportunity for a public health impact on highly. pathogenic infections.\n\nBetween 2004 and this website 2007, all candidate donors deferred before donation for reactivity of anti-HIV, hepatitis C virus antibody (anti-HCV), and hepatitis B virus surface antigen (HBsAg) rapid tests were informed and referred to a donor care program consisting of test confirmation, information, counseling, and potential referral. for follow-up and therapy. Dedicated trained nurses supervised the program including alanine aminotransferase (ALT) level testing to identify liver disease.\n\nIn a 4-year period 51,100 donors were screened and 5778, 1578, and 227 candidate ...
The profit to be gained by testing Danish blood donors for hepatitis B surface antigen (HBsAg) with a third generation technique instead of the currently used immunoelectrophoresis was investigated by additional screening of 48 750 blood units by radioimmunoassay three weeks after donation. Twenty nine units were positive for HBsAg on radioimmunoassay (0.059%). Only six of these were found by immunoelectrophoresis (0.012%). Most of the 23 donors positive on radioimmunoassay and negative on immunoelectrophoresis were healthy carriers of HBsAg (20) or had asymptomatic chronic liver disease (two). One donor had acute hepatitis B. Fifteen of the 23 blood units were transfused. The 15 recipients were monitored biochemically and serologically for up to nine months. One recipient developed fulminant hepatitis B, three developed acute hepatitis B, and one became a healthy carrier of HBsAg. All these patients had received blood from healthy carriers of HBsAg. Two recipients were immunised against HBsAg, ...
Most recent papers with the keyword HBsAg seroconversion | Read by QxMD
Our previous OSST study shows that switching to pegylated interferon (Peg-IFN)-α2a results in higher rates of response hepatitis B e antigen (HBeAg) seroconversion and hepatitis B surface antigen (HBsAg) loss at the end of treatment, compared with nucleot(s)ide analogues (NAs) monotherapy in long term NA-treated chronic hepatitis B (CHB) patients. In order to characterize the correlation between Peg-IFN-α antiviral effect and IFN-inducing signaling in CHB patients who switched to Peg-IFN from long time entecavir (ETV) treatment, we investigated the dynamic expression of interferon-stimulated genes (ISGs), including STAT1, MX, and a negative regulatory factor, suppressor of cytokine signaling 3(SOCS3), which negatively regulate IFN JAK-STAT signaling pathway by interacting with STAT1 and STAT2, in peripheral blood and paired liver samples, obtained from 54 CHB patients enrolled in a clinical trial, OSST study ...
IMMUNOGENIC COMPOSITION - Patent application
0027] In one embodiment, the antigen which elicits an immune response against a human pathogen is virally derived, e.g. HIV-1, (such as gag or fragments thereof, such as p24, tat, nef, envelope glycoproteins such as gp120, gp140 or gp160, or any fragments thereof), human herpes viruses, such as gD or derivatives thereof or Immediate Early protein such as ICP27 from HSV1 or HSV2, cytomegalovirus ((esp Human) (such as gB or derivatives thereof)), Rotaviral antigen, Epstein Barr virus (such as gp350 or derivatives thereof), Varicella Zoster Virus (such as gp1, I1 and IE63), or from a hepatitis virus such as hepatitis B virus (for example Hepatitis B virus surface antigen or a derivative thereof), or antigens from hepatitis A virus, hepatitis C virus and hepatitis E virus, or from other viral pathogens, such as paramyxoviruses, Respiratory Syncytial virus (such as F G and N proteins or derivatives thereof), parainfluenza, measles virus, mumps virus, human papilloma viruses (for example HPV 6, 11, ...
Hepatitis B, C, and D Virus Infections in Patients with Chronic Hepatitis, Cirrhosis, and Hepatocellular Carcinoma: A...
Abstract Eighty-nine Sahelian African patients with chronic active hepatitis (CAH) (14), cirrhosis (49), hepatocellular carcinoma (HCC) (26), and 47 controls were tested for hepatitis B virus (HBV, hepatitis B surface antigen [HBsAg]) and hepatitis D virus (HDV, anti-HDV antibody). Seventy-three percent of the patients were positive for HBsAg versus 29.8% of the controls (P < 0.0001). With anti-HDV test, 55.0% of the patients were positive versus 17.0% of the controls (P < 0.0001). To assess the prevalence of antibody to hepatitis C virus (HCV), we used an enzyme-linked immunosorbent assay for screening (anti-HCV2): 19.1% of the patients were positive versus 6.4% of the controls (P < 0.05). An association between HBsAg and anti-HDV-positive test results was found in 46.1% of the patients versus 6.4% of the controls (P < 0.0001). A combination of HBsAg and anti-HCV2-positive test results was found in 13.5% of the patients versus 2.2% of the controls (P < 0.05). Anti-HDV and anti-HCV2 test
EPO - T 2126/08 (Surface antigen/ORTHO-CLINICAL DIAGNOSTICS) of 23.4.2013
Summary of Facts and Submissions. I. The appeal was lodged by the applicant (hereinafter appellant) against the decision of the examining division to refuse European patent application 01303073.9 with the title A hepatitis B virus (subtype ayw) surface antigen variant which was published as EP 1 142 906.. II. Claim 1 of the application as filed read:. 1. An isolated variant hepatitis B surface antigen comprising an amino acid sequence wherein mutations from hepatitis B wild type ayw2 strain appear as follows: at position 103 isoleucine is present instead of methionine, at position 118 lysine is present instead of threonine, at position 120 glutamine is present instead of proline, at position 170 serine is present instead of leucine, and at position 213 serine is present instead of leucine.. III. The examining division decided that claim 1 of the set of claims filed by the applicant with its letter dated 26 July 2005 (which apparently is referred to incorrectly in the decision under appeal ...
Hepadnavirus Mnemonic for USMLE
Key Points - HepadnavirusKey VirusesHepatitis B virus (HBV)CharacteristicsDNA virusReplicates in nucleusReplicates using reverse transcriptasePartially double-standed DNA → polymerase completes dsDNA → transcription into RNA template (used to make viral proteins) → reverse transcription into dsDNA progenyNucleocapsid core contains hepatitis B core antigen, HBcAgEnvelopedLipoprotein envelope surrounds nucleocapsid coreContains hepatitis B surface antigen, HBsAg and envelope antigen, HBeAgCircular chromosomeTransmissionMany routesBlood (transfusion, IVDU, shared needles)Sexual contactPerinatalTransplantPathogenesisMigrates to liver and replicates in hepatocytesCauses immune-mediated damage by CD8+ T-cells and NK cellsNo direct cytotoxic effect of virusCD8+ T-cells recognize HBsAg and HBcAg presented on MHCI of hepatocytesPresentationAcute hepatitisFever, jaundice, elevated ALT and AST (ALT | AST)Most cases are acute and will undergo complete resolution (|95%)Chronic hepatitis occurs in 4-5% of
HEPATITIS B SURFACE ANTIGEN
Hep B surface antigen positive - Hepatitis B - MedHelp
HbS antigen. positive. hep e antigen.Negative.HBV DNA.Negative.I am on treatment with lumividine tab 100 mg/day for about 3 yrs ... I am diagnosed as Hep B carrier.My test reports: ... Hep B surface antigen positive. I am diagnosed as Hep B carrier ... I am diagnosed as Hep B carrier.My test reports:HbS antigen. positive. hep e antigen.Negative.HBV DNA.Negative.I am on ... liver ultrasound test normal.I wish to go abroad for a job and there Hep.B Surface antigen is tested.If one is positive, it is ...
Expression of hepatitis B surface antigen in transgenic banana plants | SpringerLink
... gene of hepatitis B surface antigen (HBsAg) using Agrobacteriummediated transformation. Four different expression... ... Agrobacterium Edible vaccine Embryogenic cells Hepatitis B surface antigen Transgenic banana Abbreviations. ADS. Adenine ... Mason HS, Lam DMK, Arntzen CJ (1992) Expression of hepatitis B surface antigen in transgenic plants. Proc Nat Acad Sci USA 89: ... Rasthali (AAB) have been transformed with the s gene of hepatitis B surface antigen (HBsAg) using Agrobacterium mediated ...
Appendix C: Identification and Management of Hepatitis B Surface Antigen (HBsAg)--Positive Persons
Identification and Management of Hepatitis B Surface Antigen (HBsAg)--Positive Persons. Persons with chronic hepatitis B virus ... obtain vaccination against hepatitis A if chronic liver disease is present (2). *When seeking medical or dental care, HBsAg- ... Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization ... Hepatitis B virus transmission between children in day care. Pediatr Infect Dis J 1989;8:870--5. ...
Hepatitis b surface antigen | Define Hepatitis b surface antigen at Dictionary.com
Hepatitis b surface antigen definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation ... hepatitis b surface antigen in Medicine Expand. hepatitis B surface antigen n. Abbr. HBsAg An antigen of the small spherical ... and filamentous forms of hepatitis B antibodies that is also present on the Dane particle. ... Nearby words for hepatitis b surface antigen. * hepatitis a * hepatitis a virus ...
JCI - Entering the spotlight: hepatitis B surface antigen-specific B cells
Recombinant Hepatitis A Virus Surface Antigen protein (ab68870)
Buy our Recombinant Hepatitis A Virus Surface Antigen protein. Ab68870 is an active protein fragment produced in Escherichia ... Recombinant Hepatitis A Virus Surface Antigen protein. See all Hepatitis A Virus Surface Antigen proteins and peptides. ... Hepatitis A virus (HAV), the causative agent of type A viral hepatitis, is spread by faecal-oral contact or ingestion of ... Microbiology Organism Virus RNA Virus ssRNA positive strand virus Hepatitis A/C/E/G ...
hepatitis B surface antigen Archives - Hepatitis B Foundation
Hepatitis B Diagnosis & Monitoring, Hepatitis B Prevention, Living with Hepatitis B Youve Lost the Hepatitis B Surface Antigen ... B news Hepatitis B Outreach hepatitis B vaccine hepatitis C hepatitis D hepatocellular carcinoma HepB hep B Hep B Awareness Hep ... HBsAghepatitis B curehepatitis B surface antigenliver cancerRobert Gishsurface antibodies. Baruch S. Blumberg Institute. Search ... Tag Archives: hepatitis B surface antigen. Hepatitis B Diagnosis & Monitoring, Hepatitis B Treatment ...
A longitudinal follow-up of asymptomatic hepatitis B surface antigen-positive Chinese children. - PubMed - NCBI
A longitudinal follow-up of asymptomatic hepatitis B surface antigen-positive Chinese children.. Lok AS1, Lai CL. ... Fifty-one asymptomatic Chinese hepatitis B surface antigen (HBsAg) carrier children (34 boys, 17 girls), age 1 to 15 years ( ... At presentation, 43 (84%) children were hepatitis B e antigen (HBeAg) positive; only two (7%) cleared HBeAg on follow-up. None ... In four of 12 instances, transient elevations in ALT levels were associated with a fall in serum hepatitis B virus DNA levels. ...
Hepatitis B surface antigen containing immune complexes occur in seronegative hepatocellular carcinoma patients. - PubMed -...
IgG, IgM and hepatitis B surface antigen (HBsAg) containing immune complexes (IC) were detected by the Clq and conglutinin ... Hepatitis B surface antigen containing immune complexes occur in seronegative hepatocellular carcinoma patients.. Brown SE, ... by sensitive commercial assays and provides evidence of a further association of hepatitis B virus (HBV) and HCC in antigen ... No differences were observed between the two patient groups either in the levels of antigen non-specific and HBsAg specific ...
Proposal for routine antenatal screening at 14 weeks for hepatitis B surface antigen | The BMJ
PREVALENCE OF HEPATITIS B SURFACE ANTIGEN. The rate of positive results for hepatitis B surface antigen was 0.7% in our ... All blood samples positive for hepatitis B surface antigen were also tested for hepatitis B e antigen and its antibody (Abbott ... and hepatitis B surface antigen. The surface antigen was measured either by radioimmunoassay (Ausria II, Abbott Laboratories, ... Of the 705 women positive for hepatitis B surface antigen, 118 (16.7%) were positive for the e antigen. The rate of positive ...
hep B Surface Antigen Positive - Forum on Hepatitis and HIV Coinfection - TheBody.com
... then the surface antigen can mean a chronic carrier state that is inactive due to no virus in her blood. Yes I would agree that ... If your wife is at risk for hepatitis B, ... hep B Surface Antigen Positive. Feb 4, 2006 My wife recently ... If your wife is at risk for hepatitis B, then the surface antigen can mean a chronic carrier state that is inactive due to no ... Yes I would agree that she should see a specialist to be certain that: 1. The hepatitis B surface antigen was confirmed. 2. To ...
Anti-Hepatitis B Virus Surface Antigen antibody [HB12] (ab2039)
Mouse monoclonal Hepatitis B Virus Surface Antigen antibody [HB12] validated for ELISA. Immunogen corresponding to recombinant ... Anti-Hepatitis B Virus Surface Antigen antibody [HB12]. See all Hepatitis B Virus Surface Antigen primary antibodies. ... Hepatitis B Virus (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the ...
Hepatitis A Surface Antigen Antibodies: Novus Biologicals
Browse our Hepatitis A Surface Antigen Antibody catalog backed by our Guarantee+. ... Hepatitis A Surface Antigen Antibodies available through Novus Biologicals. ... Hepatitis A Surface Antigen Antibodies. We offer Hepatitis A Surface Antigen Antibodies for use in common research applications ... Choose from our Hepatitis A Surface Antigen monoclonal antibodies.. Alternate Names for Hepatitis A Surface Antigen Antibodies ...
Screening of Danish blood donors for hepatitis B surface antigen using a third generation technique. | The BMJ
Screening of Danish blood donors for hepatitis B surface antigen using a third generation technique.. Br Med J (Clin Res Ed) ... Screening of Danish blood donors for hepatitis B surface antigen using a third generation technique. Br Med J (Clin Res Ed) ... The profit to be gained by testing Danish blood donors for hepatitis B surface antigen (HBsAg) with a third generation ... Screening of Danish blood donors for hepatitis B surface antigen using a third generation technique. ...
NHANES 2011-2012: Hepatitis B: Core Antibody, Surface Antigen; Hepatitis D Antibody Data Documentation, Codebook, and...
Hepatitis B surface antigen. Variable Name: LBDHBG SAS Label: Hepatitis B surface antigen. English Text: Hepatitis B surface ... they are coded negative for surface antigen if the test for surface antigen is negative or if the test for hepatitis B core ... Hepatitis B: Core Antibody, Surface Antigen; Hepatitis D Antibody (HEPBD_G) Data File: HEPBD_G.xpt First Published: September ... The Hepatitis B surface antigen is tested only when the Hepatitis B core antibody test is positive. Participant results are ...
NHANES 2005-2006: Hepatitis B: Core Antibody, Surface Antigen; Hepatitis D Antibody Data Documentation, Codebook, and...
Hepatitis B surface antigen. Variable Name: LBDHBG. SAS Label: Hepatitis B surface antigen. English Text: Hepatitis B surface ... they are coded negative for surface antigen if the test for surface antigen is negative or if the test for hepatitis B core ... Hepatitis B: Core Antibody, Surface Antigen; Hepatitis D Antibody (HEPBD_D) Data File: HEPBD_D.xpt First Published: February ... Hep B- The hepatitis B core antibody test is performed on all examinees 6 years old and older while the hepatitis B surface ...
Collaborative study to evaluate the candidate 3rd WHO international standard for hepatitis B surface antigen
Hepatitis B surface antigen, hepatitis C and HIV antibodies in a low-risk blood donor group, Nigeria Egah, D.Z.; Banwat, E.B. ... Prevalence of hepatitis B surface antigen and hepatitis C virus antibodies among blood donors in Alexandria, Egypt Wasfi, O.A ... Serum level of anti-hepatitis B surface antigen 6-8 years after hepatitis B vaccination at birth Kazemi, A.; Koosha, A.; ... were tested for hepatitis B surface antigen [HBsAg] and anti-hepatitis C virus [HCV] antibodies. A total of 119 donors [ ...
Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen | Science
The 55 codons upstream of the gene sequence encoding the hepatitis B surface antigen (HBsAg) are called the pre-S(2) region. It ... Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen ... Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen ... Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen ...
21 CFR Part 660, Subpart A - Antibody to Hepatitis B Surface Antigen | US Law | LII / Legal Information Institute
Hepatitis D Virus Infection Among Hepatitis B Virus Surface Antigen Positive Individuals - Tabular View - ClinicalTrials.gov
Hepatitis D Virus Infection Among Hepatitis B Virus Surface Antigen Positive Individuals. The safety and scientific validity of ... Hepatitis D virus (HDV) is an incomplete RNA virus that needs hepatitis B surface antigen (HBsAg) to help its replication. HDV ... Hepatitis D Virus Infection Among Hepatitis B Virus Surface Antigen Positive Individuals in Upper Egypt: Prevalence and ... Hepatitis D Virus Infection Among Hepatitis B Virus Surface Antigen Positive Individuals ...
Recommendations for the Management of Donor and Units that are Initially Reactive for Hepatitis B Surface Antigen (HBsAg) | FDA
Detecting Hepatitis B Surface Antigen Mutants - Volume 12, Number 2-February 2006 - Emerging Infectious Diseases journal - CDC
Detecting Hepatitis B Surface Antigen Mutants On This Page Mechanism of HBV Mutant Generation Surface Antigen Structure Surface ... of hepatitis B surface antigen epitopes present on variants and specifically recognized by anti-hepatitis B surface antigen ... Surface Antigen Structure. The translational products of the surface antigen gene consist of 3 proteins that have different ... Carman W, van Deursen F, Mimms L, Hardie D, Coppola R, Decker R, The prevalence of surface antigen variants of hepatitis B ...
HBsAg Antibody | Hepatitis B virus surface antigen | ProSpec
HBsAg is a serological marker produced on the surface of the hepatitis B virus and is one of the first disease state markers to ... HBsAg is the surface antigenof the Hepatitis-B-Virus (HBV). The capsidof a virus has different surface proteins from the rest ... The antigen is a protein that binds specifically on one of these surface proteins. It is commonly referred to as the Australian ... Antigen.. Description. HBsAg is a serological marker produced on the surface of the hepatitis B virus and is one of the first ...
HBsAg adw2 Protein | Hepatitis B Surface Antigen | ProSpec
HBsAg is the surface antigenof the Hepatitis-B-Virus (HBV). The capsidof a virus has different surface proteins from the rest ... The antigen is a protein that binds specifically on one of these surface proteins. It is commonly referred to as the Australian ... Antigen. Description. HbsAg subtype adw2 produced in E.Coli, is a single, non-glycosylated, polypeptide chain containing 226 ...
Hepatitis B Surface Antigen Neutralization-CRL Infectious Diseases
Requalification Method for Reentry of Donors Who Test Hepatitis B Surface Antigen (HBsAg) Positive Following a Recent...
Requalification Method for Reentry of Donors Who Test Hepatitis B Surface Antigen (HBsAg) Positive Following a Recent ... Requalification Method for Reentry of Donors Who Test Hepatitis B Surface Antigen (HBsAg) Positive Following a Recent ... method or process for the reentry of deferred donors who test repeatedly reactive for hepatitis B surface antigen (HBsAg), ... confirmed positive by neutralization, following a recent vaccination against hepatitis B virus (HBV) infection, and who are not ...
Response-guided peginterferon therapy in hepatitis B e antigen-positive chronic hepatitis B using serum hepatitis B surface...
Kinetics of Hepatitis B Surface Antigen Level in Chronic Hepatitis B Patients who Achieved Hepatitis B Surface Antigen Loss ... Response-guided peginterferon therapy in hepatitis B e antigen-positive chronic hepatitis B using serum hepatitis B surface ... Early hepatitis B surface antigen decline predicts treatment response to entecavir in patients with chronic hepatitis B, ... Association Between Serum Level of Hepatitis B Surface Antigen at End of Entecavir Therapy and Risk of Relapse in E Antigen- ...
Determinants of spontaneous surface antigen loss in hepatitis B e antigen-negative patients with a low viral load - Tseng -...
Determinants of spontaneous surface antigen loss in hepatitis B e antigen-negative patients with a low viral load†‡. ... Determinants of spontaneous surface antigen loss in hepatitis B e antigen-negative patients with a low viral load. Hepatology, ... HEP_24615_sm_SuppTabs.doc. 51K. Supporting Table 1. Time-to-HBsAg loss in patients with different ranges of HBsAg levels. ... Viral Hepatitis. You have free access to this content. ... Hepatitis Research Center, National Taiwan University Hospital ...
Serum hepatitis B surface antigen titer and transient elastography in | TCRM
To explore the predictive value of serum hepatitis B surface antigen (HBsAg) titer and transient elastography in screening for ... B surface antigen titer and transient elastography in screening for insignificant fibrosis in HBeAg-positive chronic hepatitis ... insignificant fibrosis in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients. Methods: We conducted a cross- ... We assessed the serum HBsAg level, serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) level, HBV genotypes, liver ...
HBsAgAcuteLiverMonoclonalSpecificityVaccineVaccinationHBcAg10.1002Core antibodyImmunogenPatientsProteinProteinsHuman leukocytInfection with hepatitis B virDetectionDonorsCarriers of hepatitisCirrhosisELISAViral antigensPositive for hepatitis B surfaceSerological evidence of hepatitisClinicalPregnant womenPrevalence of hepatitisAntibodies against hepatitisInfectionsHBeAgReactiveHepaticVirusesSerum hepatitis B virGlycoproteinVirus surfaceImmunizationReactsSubstancesSubtypeCarrierNonreactive
- Rasthali (AAB) have been transformed with the ' s ' gene of hepatitis B surface antigen (HBsAg) using Agrobacterium mediated transformation. (springer.com)
- In contrast, B cells producing neutralizing antibodies against the HBV surface antigen (HBsAg) have been studied in little detail, mainly due to methodical limitations. (jci.org)
- HBsAg, the protein that makes up the surface of the virus, is what labs look for in a blood sample to determine if a person is currently infected with hepatitis B. (hepb.org)
- The strange thing about HBsAg, is that each hepatitis B virus requires only about 100 HBsAg molecules to provide its envelope protein, but the virus produces about 100- to 1 million-times more HBsAg than is needed, leaving millions of HBsAg circulating in the bloodstream," explained Timothy Block, president of the Hepatitis B Foundation and the Baruch S. Blumberg Institute, the foundation's research arm. (hepb.org)
- Bottom line: A low or undetectable HBsAg level means patients are winning the war against hepatitis B and their risk of liver damage is greatly reduced. (hepb.org)
- According to Quest Diagnostics, which created the test, measuring HBsAg levels better identifies which patients are at risk of hepatitis B reactivation. (hepb.org)
- Fifty-one asymptomatic Chinese hepatitis B surface antigen (HBsAg) carrier children (34 boys, 17 girls), age 1 to 15 years (median: 10 years), were prospectively followed for up to 4 years (median: 30 months) to determine the natural evolution of clinical, biochemical and virological features during the early phase of chronic hepatitis B virus infection. (nih.gov)
- IgG, IgM and hepatitis B surface antigen (HBsAg) containing immune complexes (IC) were detected by the Clq and conglutinin solid phase assays in both HBsAg+ and HBsAg- groups of patients with primary hepatocellular carcinoma (HCC). (nih.gov)
- No differences were observed between the two patient groups either in the levels of antigen non-specific and HBsAg specific complexes or in the immunoglobulin isotype in the complexes. (nih.gov)
- The results show that HBsAg can occur in an IC form in the sera of patients classified as HBsAg- by sensitive commercial assays and provides evidence of a further association of hepatitis B virus (HBV) and HCC in antigen negative patients. (nih.gov)
- The profit to be gained by testing Danish blood donors for hepatitis B surface antigen (HBsAg) with a third generation technique instead of the currently used immunoelectrophoresis was investigated by additional screening of 48 750 blood units by radioimmunoassay three weeks after donation. (bmj.com)
- One recipient developed fulminant hepatitis B, three developed acute hepatitis B, and one became a healthy carrier of HBsAg. (bmj.com)
- We determined the serum level of antibody to hepatitis B surface antigen [anti-HBsAg] in 273 randomly selected 7-9-year-old schoolchildren from Zanjan City, Islamic Republic of Iran, who had been fully vaccinated against hepatitis B starting at birth. (who.int)
- The 55 codons upstream of the gene sequence encoding the hepatitis B surface antigen (HBsAg) are called the pre-S(2) region. (sciencemag.org)
- Hepatitis D virus (HDV) is an incomplete RNA virus that needs hepatitis B surface antigen (HBsAg) to help its replication. (clinicaltrials.gov)
- To estimate the prevalence of hepatitis D virus infection among HBsAg positive individuals. (clinicaltrials.gov)
- Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. (cdc.gov)
- An understanding of immunoassay reactivity with HBsAg mutants is key to establishing an appropriate testing algorithm for hepatitis B virus detection programs. (cdc.gov)
- This article addresses recent information concerning the emergence of hepatitis B surface antigen (HBsAg) mutants, their impact on viral antigen presentation, latest prevalence data, and discussion of the issues associated with detection of mutants in healthcare settings. (cdc.gov)
- HBsAg is the surface antigenof the Hepatitis-B-Virus (HBV). (prospecbio.com)
- HBsAg is a serological marker produced on the surface of the hepatitis B virus and is one of the first disease state markers to be detected in the serum of patients infected with the hepatitis B virus. (prospecbio.com)
- This guidance provides recommendations for a requalification method or process for the reentry of deferred donors who test repeatedly reactive for hepatitis B surface antigen (HBsAg), confirmed positive by neutralization, following a recent vaccination against hepatitis B virus (HBV) infection, and who are not infected by HBV. (fda.gov)
- To explore the predictive value of serum hepatitis B surface antigen (HBsAg) titer and transient elastography in screening for insignificant fibrosis in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients. (dovepress.com)
- We assessed the serum HBsAg level, serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) level, HBV genotypes, liver stiffness measurement (LSM) values by transient elastography, and histological fibrosis staging by METAVIR classification. (dovepress.com)
- Hepatitis B virus surface antigen (HBsAg) is an important risk factor for hepatocellular carcinoma (HCC) and is downregulated during hepatocarcinogenesis. (sigmaaldrich.com)
- An open-label randomized study was undertaken to compare a 2-dose regimen (Months 0 and 6) of hepatitis B surface antigen (HBsAg) vaccine formulated with a novel adjuvant (HBsAg/AS04) with a standard 3-dose regimen (Months 0, 1 and 6) of licensed recombinant HBsAg vaccine in terms of immunogenicity and reactogenicity when administered to healthy subjects aged between 15 and 40 y. (arctichealth.org)
- The primary objective is to demonstrate the efficacy of combination therapy (Peg-IFN and adefovir or Peg-IFN and tenofovir) for inducing loss of HBsAg compared to no-treatment in HBeAg negative chronic hepatitis B patients with low viral load. (clinicaltrials.gov)
- A total of 69 persons were investigated for assessment of cell-mediated and humoral immunity to hepatitis B surface antigen (HBsAg). (asm.org)
- Three groups, each consisting of 20 normal persons, 20HBsAg carriers, and 20 convalescent hepatitis B patients, were studied for HBsAg, anti-HBs, and leukocyte migration inhibition with purified HBsAg. (asm.org)
- Sequential sampling if an additional group of nine acute hepatitis B patients defined the cellular and humoral immune response to HBsAg. (asm.org)
- The antigen was eliminated rapidly by mounting of cell-mediated immune response detectable for a limited period, followed by antibody response in relatively few patients moore than 3 months after clearance of circulating HBsAg. (asm.org)
- To test the effect of daily lamivudine (100 mg) in reducing the risk of HBV reactivation and hepatitis development in HBsAg (+) NHL patients. (clinicaltrials.gov)
- Thirty-five cases with hepatitis B surface antigen (HBsAg) positivity known prior to initiation of TNF-α inhibitors were identified. (springer.com)
- While such reactivation may be due to a variety of reasons, clinicians prescribing TNF-α inhibitors to HBsAg-positive patients should consider prophylactic antiviral therapy and close monitoring for any clinical or serological evidence of hepatitis. (springer.com)
- The age-specific prevalence of hepatitis B surface antigen (HBsAg) and antibody was studied in a random sample of Gilbert and Ellice islanders over the age of 10 years living in Nauru. (ajtmh.org)
- The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). (genetex.com)
- Hepatitis B infection is normally diagnosed from serological tests that detect HBsAg but as the disease progresses this antigen may no longer be present in the blood and tests for HBcAg are used. (genetex.com)
- If HBsAg can be detected in the blood for longer than six months, chronic hepatitis B is diagnosed. (genetex.com)
- Percentage of HBsAg-positive subjects detected using the hepatitis sAg/eAg test versus the HBsAg standard provided by NIBSC. (asm.org)
- For comparing factors between AHB patients with viral persistence and those with self-limited infection, 212 AHB patients without human immunodeficiency virus (HIV) coinfection were observed in 38 liver centers until serum hepatitis B surface antigen (HBsAg) disappeared or a minimum of 6 months in cases where HBsAg persisted. (sigmaaldrich.com)
- Many cell types efficiently present an epitope of the hepatitis B surface Ag (HBsAg) to murine class I-restricted CTL following an in vitro pulse with native 22-nm HBsAg particles. (jimmunol.org)
- We have analyzed the molecular bases of the persistence of hepatitis B virus (HBV) DNA in serum and peripheral blood mononuclear cells (PBMC) in the absence of detectable hepatitis B surface antigen (HBsAg) in hemodialysis patients and dialysis-unit staff members who had suffered acute hepatitis B that resolved previously. (nih.gov)
- No serum HBsAg/hepatitis B surface antigen antibody (anti-HBs) immune complexes or mutations in the "a determinant of the S gene were found. (nih.gov)
- HBsAg serum level (quantification) may be useful for managing hepatitis B virus (HBV) infection patients. (scirp.org)
- The objective of this study was to estimate the correlation between HBsAg serum level and liver fibrosis severity with treatment naive chronic hepatitis B patients in Cote d'Ivoire. (scirp.org)
- Conclusion: This study shows that there's a negative correlation between HBsAg serum level and liver fibrosis severity treatment naive with African chronic hepatitis B viral HBeAg-negative patients. (scirp.org)
- Home » Products » Health Beauty » Diagnosis Equipment » HBsAg Test Strip/Hepatitis B Surface Antigen Test In total 213268 number ofProductsinfo，Released today. (dahmw.org)
- The hepatitis B surface antigen (HBsAg) S1 protein forms nanoparticles that can be utilized both as an immunogenic array of the MPER and to provide the lipid environment needed for enhanced 2F5 and 4E10 binding. (iavi.org)
- Native HBV antigen HBsAg. (abnova.com)
- Hepatitis B surface antigen (HBsAg) is a marker ofinfectivity. (abnova.com)
- The hepatitis B virus surface antigen (HBsAg) is a key target molecule in developing vaccines and diagnostic systems. (ku.edu)
- For this purpose, the HBsAg coding gene was cloned into a pCANTAB5E phagemid vector and expressed on the surface of M13 filamentous phages. (ku.edu)
- Thus, the development of a highly efficient process for the preparation of a vaccine based on a recombinant hepatitis B surface antigen (HBsAg) is very important to the Chinese national immunization program. (diva-portal.org)
- Anti-idiotype antibodies that recognize a common human idiotype present on antibodies to hepatitis B surface antigen (anti-HBs) from individuals naturally infected by hepatitis B virus (HBV) and an interspecies idiotype on anti-HBs produced by active immunization with hepatitis B surface antigen (HBsAg) were used in vivo to modulate idiotype networks in mice. (springer.com)
- Hepatitis B surface antigen (HBsAg) expression cassettes were inserted into this cDNA and three MVs expressing HBsAg at different levels generated. (asm.org)
- The widely used HBV vaccine is based on Saccharomyces cerevisiae -expressed small surface antigen (hepatitis B surface antigen [HBsAg]) and has a three-dose schedule ( 22 ). (asm.org)
- HBsAg was detected more frequently in chronic aggressive hepatitis and active cirrhosis than in chronic persistent hepatitis and cirrhosis with little activity. (bmj.com)
- No correlation was found in the different forms of chronic hepatitis between the HBsAg status on the one hand, and levels of transaminases, gammaglobulins, and auto-antibodies on the other. (bmj.com)
- In conclusion, HBV DNA in serum and PBMC is detectable in a high proportion of HBsAg-negative hemodialysis patients and may persist several years after a resolved acute hepatitis B. The viral DNA is encapsulated and remains transcriptionally active in PBMC. (asnjournals.org)
- Here, we investigated hepatitis B surface antigen (HBsAg) genetic features underlying this phenomenon by analyzing 93 patients: 29 developing HBV reactivation and 64 consecutive patients with chronic HBV infection (as control). (uni-koeln.de)
- Hepatitis B surface antigen (HBsAg) loss is a rare event during nucleos(t)ide analogue (Nuc) therapy. (snfge.org)
- Limited data suggest that stopping Nuc therapy may increase HBsAg loss rate in hepatitis B e antigen-negative patients. (snfge.org)
- Baseline and on-treatment clinical and viral features, treatment duration, consolidation duration, time to undetectable hepatitis B virus DNA, time to normal alanine aminotransferase, end-of-treatment HBsAg, and HBsAg log reduction were compared between patients with and without HBsAg seroclearance after end of treatment. (snfge.org)
- The aim of this study was to determine the prevalence of Hepatitis B surface antigen (HBsAg) and its risk factors, among individuals visiting Shashemene General Hospital VCT center. (biomedcentral.com)
- Blood samples were collected and screened for hepatitis B surface antigen (HBsAg) and HIV by commercially available rapid test kits. (biomedcentral.com)
- Small volumes of Hepatitis B Surface Antigen HBsAg adw recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. (mybiosource.com)
- Patients who are HBsAg positive develop chronic persistent hepatitis (CPH) and chronic active hepatitis (CAH). (mybiosource.com)
- This immunoassay measures HBsAg through antigen-antibody interactions. (mybiosource.com)
- NCBI/Uniprot data below describe general gene information for Hepatitis B Surface Antigen HBsAg adw . (mybiosource.com)
- Hepatitis B Surface Antigen - Test blood donors (HBsAg positive individuals are rejected). (walkinlab.com)
- Patients who are negative for HBsAg may still have acute type B viral hepatitis. (walkinlab.com)
- On such occasions, both tests for anti-HBc are usually positive and anti-HBc, IgM is the only specific marker for the diagnosis of acute infection with hepatitis B. In cases with strong clinical suspicion of viral hepatitis, serologic testing should not be limited to detecting HBsAg, but should include a battery of tests to evaluate different stages of acute and convalescent hepatitis. (walkinlab.com)
- We developed an immunogen to stimulate multivalent immunity against hepatitis B surface antigen (HBsAg) and hepatitis B core antigens (HBcAg). (ac.ir)
- Fermentations were performed to determine parameters affecting the expression of hepatitis B surface antigen (HBsAg) in the yeastSaccharomyces cerevisiae containing the HBsAg gene. (semanticscholar.org)
- The particulate forms of HBsAg were analysed for the presence of HBeAG on their surfaces. (microbiologyresearch.org)
- The objectives of the study were to evaluate the prevalence, incidence and clinical significance of antibodies to hepatitis C virus in HBsAg chronic carriers. (actamedicaportuguesa.com)
- The HBV surface protein antigens (HBsAg) are comprised of large (LHBs), middle (MHBs) and small (SHBs, also called major) protein. (arigobio.com)
- One donor had acute hepatitis B. Fifteen of the 23 blood units were transfused. (bmj.com)
- Hepatitis viruses constitute a major public health problem because of the morbidity and mortality associated with the acute and chronic consequences of these infections. (cdc.gov)
- Co-infection with hepatitis D virus (HDV) in persons with acute or chronic hepatitis B virus (HBV) infection can lead to fulminant hepatitis. (cdc.gov)
- About 20% to 30% of coinfections of HDV and HBV in humans develop fatal fulminant hepatitis versus 2% of patients with acute hepatitis B mono-infection. (clinicaltrials.gov)
- Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state. (arctichealth.org)
- Acute viral hepatitis A, B and non-A, non-B in Stockholm in the 1950s and 1970s: a comparison. (arctichealth.org)
- Risk factors for long-term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults. (sigmaaldrich.com)
- The proportion of patients who progress to chronicity following acute hepatitis B (AHB) varies widely worldwide. (sigmaaldrich.com)
- Hepatitis B surface antigen is the earliest indicator of the presence of acute infection. (specialtylabs.com)
- Hepatitis B virus (HBV) acute and chronic infections remain a major worldwide health problem. (asm.org)
- eight of the 24 staff members had an acute hepatitis B resolved 13 to 21 yr before. (asnjournals.org)
- HBV DNA was detected in PBMC of four of six staff members (all with previous acute hepatitis). (asnjournals.org)
- Hepatitis B virus (HBV) reactivation during immunosuppression can lead to severe acute hepatitis, fulminant liver failure, and death. (uni-koeln.de)
- Hepatitis B surface antigens are an early sign of an acute infection, and they are also present during chronic, or long-term, infection. (vidanthealth.com)
- hep e antigen.Negative.HBV DNA.Negative.I am on treatment with lumividine tab 100 mg/day for about 3 yrs.My ALT level & liver ultrasound test normal.I wish to go abroad for a job and there Hep.B Surface antigen is tested.If one is positive, it is a sure rejection.Can inj. (medhelp.org)
- Persons with chronic hepatitis B virus (HBV) infection are at high risk for chronic liver disease and are a major reservoir of HBV infection. (cdc.gov)
- In this study, we demonstrated that chronic hepatitis B virus infection in asymptomatic Chinese children is usually associated with a mild and stable liver disease despite high levels of hepatitis B virus replication. (nih.gov)
- Hepatitis B Virus (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the extent of liver damage, inflammation and viral persistence. (abcam.com)
- Antibodies to hepatitis C virus, hepatitis B serology and liver enzymes were examined in 137 Finnish haemophiliac patients to detect signs of chronic viral hepatitis and its possible aetiological associations. (arctichealth.org)
- Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. (genetex.com)
- Hepatitis B virus (HBV) is one of the major causes of chronic hepatitis, cirrhosis and liver cancer. (ku.edu)
- Hepatitis B virus (HBV) infection is significant health problem, as it can lead to chronic hepatitis, liver cirrhosis, and hepatic carcinoma. (biomedcentral.com)
- Hepatitis B is an infection of the liver caused by the hepatitis B virus. (mybiosource.com)
- Hep G2 (or HepG2) is a human liver cancer cell line. (wikipedia.org)
- Hep G2 is an immortal cell line which was derived in 1975 from the liver tissue of a 15-year-old Caucasian male from Argentina with a well-differentiated hepatocellular carcinoma. (wikipedia.org)
- This can be important for the study of human liver diseases that are caused by an incorrect subcellular distribution of cell surface proteins, e.g., hepatocanalicular transport defects such as Dubin-Johnson Syndrome and progressive familial intrahepatic cholestasis (PFIC), and familial hypercholesterolemia. (wikipedia.org)
- citation needed] Hep G2 cells and their derivatives are also used as a model system for studies of liver metabolism and toxicity of xenobiotics, the detection of environmental and dietary cytotoxic and genotoxic (and thus cytoprotective, anti-genotoxic, and cogenotoxic) agents, understanding hepatocarcinogenesis, and for drug targeting studies. (wikipedia.org)
- Hep G2 cells are also employed in trials with bio-artificial liver devices. (wikipedia.org)
- Higher monoclonal antibody binding of 67.87% of the antigen was observed when it was expressed with a C-terminal ER retention signal. (springer.com)
- Choose from our Hepatitis A Surface Antigen monoclonal antibodies. (novusbio.com)
- Horseradish peroxidase (HRP)-labeled antibody conjugate (mouse monoclonal anti-HBc) is then allowed to react with the remaining exposed HBcAg on the well surface. (cdc.gov)
- Mouse monoclonal antibody raised against native hepatitis B virus surface antigen. (abnova.com)
- Mouse monoclonal antibody raised against full length recombinant hepatitis B virus surface antigen. (abnova.com)
- To determine the need for immunization of health workers with antibody to hepatitis B surface antigen (anti-HBs) as their only serologic marker of previous hepatitis B exposure, we studied the level, persistence, and immunologic specificity of isolated anti-HBs in 46 persons identified during screening for hepatitis B vaccine. (annals.org)
- Although some persons with naturally acquired, isolated anti-HBs may be protected from hepatitis B, the immunologic specificity and protective value of anti-HBs, especially when levels are low, remain questionable. (annals.org)
- Unvaccinated sex partners and household and needle-sharing contacts should be tested for susceptibility to HBV infection (see Appendix A, Prevaccination Serologic Testing for Susceptibility) and should receive the first dose of hepatitis B vaccine immediately after collection of blood for serologic testing. (cdc.gov)
- Since the availability of hepatitis B vaccine the prevention of perinatal transmission of hepatitis B virus has become feasible. (bmj.com)
- A 2-dose regimen of a recombinant hepatitis B vaccine with the immune stimulant AS04 compared with the standard 3-dose regimen of Engerix-B in healthy young adults. (arctichealth.org)
- In 1991, the World at least 6-8 years before with 3 doses of Health Organization (WHO) recommended hepatitis B vaccine starting at birth to that hepatitis B vaccination be included provide information on the effect of the in national immunization programmes in immunization strategy for hepatitis B and countries with a hepatitis B surface antigen the need for booster doses. (who.int)
- We rescreened these persons 1 year later, administered a single dose of hepatitis B vaccine, and determined the anti-HBs level at 1, 2, and 8 weeks after vaccination. (annals.org)
- Hepatitis B vaccine is effective in preventing infection with hepatitis B virus (HBV), but its duration of protection is unknown. (ovid.com)
- Work towards developing recombinant MV with additional vaccine specificities has begun: genes from hepatitis B virus (HBV) ( 43 ), simian and human immunodeficiency viruses ( 24 , 52 ), mumps virus ( 50 ), and West Nile virus ( 10 ) have been inserted into different positions in the MV genome and thus expressed at different levels. (asm.org)
- Hepatitis B is a major public health problem, killing 1-2 million people annually, despite the introduction of an effective vaccine in 1982. (thescipub.com)
- Approximately 400 million persons worldwide have chronic hepatitis B. This is due to problems associated with vaccine delivery, stability and cost. (thescipub.com)
- The production level of hepatitis B pseudoviral particles was estimated to be 0.4 mg/1 culture, which compares favourably with the reported levels initially obtained in yeast, indicating the potential of the Aspergillus expression system as an alternative, cost-effective vaccine production system. (sun.ac.za)
- Give the dose of monovalent hepatitis B vaccine preferably within 24 hours of birth, and definitely within 7 days. (health.gov.au)
- 21 Infants should receive 3 subsequent doses of a hepatitis B-containing vaccine at 2, 4 and 6 months of age, so that they receive a total of 4 doses of hepatitis B-containing vaccines. (health.gov.au)
- in infants born to mothers with chronic hepatitis B 3-12 months after completing the primary vaccine course. (health.gov.au)
- Breakthrough cases of Hepatitis B are primarily attributed to mutations in the Hepatitis B virus (HBV) that make HBV surface proteins unrecognizable to antibodies produced from the HBV vaccine. (wikipedia.org)
- 8%). During delivery of recommended hepatitis B vaccination services (e.g. (cdc.gov)
- The duration of protection after hepatitis B vaccination in children is unknown. (who.int)
- It has been reported that when hepatitis services is good throughout the territory, B vaccination is initiated at birth, there and vaccinations are delivered through local is an increased likelihood that the child health districts which are able to reach the will complete the series [ 8,9 ] hence an whole population. (who.int)
- A boost in antibody to hepatitis B surface antigen (anti-HBs) was defined as a fourfold rise in levels to ≥20 mIU/mL that was not accompanied by the presence of antibody to hepatitis B core antigen or attributable to interim vaccination. (ovid.com)
- After completion of HBV vaccination course, 71 (87.7%) infants had protective anti-HBs levels, three (3.7%) were hepatitis B surface antigen-positive, and seven (8.6%) were hepatitis B surface antigen-negative with nonprotective anti-HBs levels. (ovid.com)
- The hepatitis B virus (HBV) vaccination schedule in Libya follows international recommendations (1st dose at birth, 2nd after 1 month and 3rd after 6 months). (hud.ac.uk)
- See Serological testing following hepatitis B vaccination . (health.gov.au)
- doi: 10.1002/hep.29640. (snfge.org)
- A total of 1000 randomly selected hepatitis B surface antigen-negative sera from blood donors were tested for hepatitis B core antibody and hepatitis B surface antibody using an ELISA and nested polymerase chain reaction was done using primers specific to the surface gene (S-gene). (ajol.info)
- This study reveals the 5.5% prevalence of occult hepatitis B among Malaysian blood donors as well as the reliability of using hepatitis B core antibody in screening for occult hepatitis B infection in low endemic, low socioeconomic settings. (ajol.info)
- Before HBV reactivation, 51.7% of patients were isolated hepatitis B core antibody (anti-HBc) positive, 31.0% inactive carriers, 6.9% anti-HBc/anti-HBs (hepatitis B surface antibody) positive, 6.9% isolated anti-HBs positive, and 3.4% had an overt HBV infection. (uni-koeln.de)
- Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)
- so why should patients get this test and how will it help the millions of people around the world infected with hepatitis B? (hepb.org)
- Hepatitis B surface antigen containing immune complexes occur in seronegative hepatocellular carcinoma patients. (nih.gov)
- In Upper Egypt, data about the prevalence, clinical, laboratory and virological characters of Hepatitis D virus-infected patients is rare. (clinicaltrials.gov)
- Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. (cdc.gov)
- The proportion of patients with clinically apparent hepatitis increased with age (P less than .01), ranging from 9.5% of infections in patients who were four years of age or less to 33.3% of infections in patients who were 30 years of age or older. (arctichealth.org)
- Among patients who were four years of age or less when infected, 28.8% became chronic carriers of hepatitis B, as compared with 7.7% of those who were 30 years of age or older. (arctichealth.org)
- A Randomized Prospective Open-label Trial for Comparing Combination Therapy Peg-Interferon Alfa-2a/Adefovir Dipivoxil and Peg-Interferon Alfa-2a/Tenofovir Disoproxil Fumarate Versus no Treatment in HBeAg Negative Chronic Hepatitis B Patients With Low Viral Load. (clinicaltrials.gov)
- Study population: The study population will consist of 150 patients chronically infected with hepatitis B virus with low viral load and HBeAg negativity. (clinicaltrials.gov)
- Study end-points: The major end-point: hepatitis B reactivation in NHL patients---defined by higher than 10-fold increase of serum HBV DNA level and/or reappearance of HBeAg in the serum during and within 6 months after chemotherapy. (clinicaltrials.gov)
- Hepatitis B Surface Antigen Serum Level Is Correlated with Fibrosis Severity in Treatment-Naïve, Chronic Hepatitis B Patients in Côte d'Ivoire (West Africa)? (scirp.org)
- Hepatitis-B surface antigen and antibody in Black and White patients with venereal diseases. (bmj.com)
- chronic active hepatitis and cirrhotic patients in the Pisa cohort are comparable to those HBeAg-negative patients classified as immune clearance phase in the Hannover cohort. (asm.org)
- Hepatitis B virus DNA in serum and blood cells of hepatitis B surface antigen-negative hemodialysis patients and staff. (asnjournals.org)
- Patients undergoing chronic hemodialysis, as well as dialysis staff members, are at high risk of infection with hepatitis B virus (HBV). (asnjournals.org)
- In the anti-HBs-negative patients, HBV DNA is, at the present time, the only means for diagnosing a past HBV hepatitis. (asnjournals.org)
- Patients may get an HLA-B27 antigen test to find the cause of joint swelling and pain. (reference.com)
- The antigen is a protein that binds specifically on one of these surface proteins. (prospecbio.com)
- Three of the children had antibodies to hepatitis B core protein. (who.int)
- Recombinant protein corresponding to full length hepatitis B virus surface antigen. (abnova.com)
- Nested PCR results showed the presence of hepatitis B viral DNA in all the 55 samples that were positive for core protein, which is in agreement with the hepatitis B surface antibody result. (ajol.info)
- Use of pre-s protein-containing hepatitis B virus surface antigens and" by J S. Yum, B C. Ahn et al. (usu.edu)
- The filamentous fungus Aspergillus niger was transformed with the hepatitis B virus S gene encoding the major viral envelope protein under control of the constitutive A. nidulans glyceraldehyde-3-phosphate dehydrogenase (gpdA) promoter. (sun.ac.za)
- The capsidof a virus has different surface proteins from the rest of the virus. (prospecbio.com)
- The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. (genetex.com)
- HBV has proteins called antigens on its surface that cause your immune system to make antibodies. (vidanthealth.com)
- Because of their high degree of morphological and functional differentiation in vitro, Hep G2 cells are a suitable model to study the intracellular trafficking and dynamics of bile canalicular, sinusoidal membrane proteins, and lipids in human hepatocytes in vitro. (wikipedia.org)
- Human leukocyte antigens help regulate the immune system, and their main role is to let the body tell the difference between normal cells and substances that it needs to attack, states MedlinePlus. (reference.com)
- Conditions such as arthritis, ankylosing spondylitis and inflammation of the sacroiliac joint may cause an increase in HLA-B27 and human leukocyte antigens, states MedlinePlus. (reference.com)
Infection with hepatitis B vir1
- Overall, 79% of subjects showed evidence of past infection with hepatitis B virus with the highest prevalence among young people. (ajtmh.org)
- Assay is a chemiluminescent immunoassay for the qualitative detection of hepatitis B surface antigen in human serum and plasma. (bloodworksnw.org)
- Screening of Danish blood donors for hepatitis B surface antigen using a third generation technique. (bmj.com)
- Wantzin P , Nielsen J O , Tygstrup N , Soerensen H , Dybkjaer E . Screening of Danish blood donors for hepatitis B surface antigen using a third generation technique. (bmj.com)
- Conclusions: The prevalence of HCV infection in asymptomatic chronic carriers is higher than in blood donors but lower than previously reported for other populations of chronic hepatitis B cases. (actamedicaportuguesa.com)
Carriers of hepatitis4
- To develop a low cost, high compliance screening programme for identification of carriers of hepatitis B surface antigen in the obstetric population of the Netherlands. (bmj.com)
- Twenty-five (13.3%) of the 188 individuals who were studied became chronic carriers of hepatitis B surface antigen. (arctichealth.org)
- About 10% of the Chinese population are chronic carriers of hepatitis B virus (HBV). (diva-portal.org)
- Hepatitis C virus antibodies in asymptomatic chronic carriers of hepatitis B surface antigen. (actamedicaportuguesa.com)
- Hepatitis B and hepatitis C viruses (HBV and HCV) are life-threatening infections of public health importance due to their association with cirrhosis and hepatocellular carcinoma. (hindawi.com)
- Background and aim: Hepatitis B virus (HBV) is one of the main causes of hepatitis and can lead to hepatic cirrhosis. (sid.ir)
- The expression levels of the antigen in the plants grown under in vitro conditions as well as the green house hardened plants were estimated by ELISA for all the four constructs. (springer.com)
- We offer Hepatitis A Surface Antigen Antibodies for use in common research applications: ELISA, Radioimmunoassay. (novusbio.com)
- ELISA procedures provide a means for routinely detecting antibodies to specific antigens. (cdc.gov)
- The International Immunodiagnostics HDV Ab assay is a competitive enzyme immunoassay (ELISA) for the determination of antibodies to Hepatitis D Virus or HDV in human plasma and sera with a 'two step" methodology. (cdc.gov)
Positive for hepatitis B surface2
- Pregnant women who are positive for hepatitis B surface antigen should be identified before delivery to prevent hepatitis B infection in their neonates by passive or active immunisation, or both. (bmj.com)
- Of the 1000 samples 55 (5.5%) were found to be reactive, of which 87.3% (48/55) were positive for hepatitis B surface antibody, indicating immunity as a result of previous infection however, that does not exclude active infection with escaped mutant HBV. (ajol.info)
Serological evidence of hepatitis1
- Prospective serological surveys of 1,280 seronegative Yupik Eskimos, performed between 1971 and 1976, identified 189 (14.8%) who developed serological evidence of hepatitis B virus infection. (arctichealth.org)
- This study investigated the seroprevalence of antihepatitis B surface antibodies (anti-HBs) and HCV antibodies among pregnant women in Mwanza city to provide data that can be used in devising preventive strategies. (hindawi.com)
Prevalence of hepatitis3
- prevalence of hepatitis B surface antigen in large cities and rural area. (bmj.com)
- To determine the prevalence of hepatitis D virus active infection. (clinicaltrials.gov)
- Yupik Eskimos of southwestern Alaska have the highest known prevalence of hepatitis B virus infection of any general population in the United States. (arctichealth.org)
Antibodies against hepatitis1
- four, six and sixteen weeks and plasma was analyzed for antibodies against hepatitis B by an enzyme linked immunoassay. (pda.org)
- NHANES testing for markers of infection with hepatitis viruses will be used to determine secular trends in infection rates across most age and racial/ethnic groups, and will provide a national picture of the epidemiologic determinants of these infections. (cdc.gov)
- Hepatitis B and C virus infections are common serious complications of blood transfusion. (who.int)
- Infections with HBV and HCV during pregnancy have been associated with high risk of vertical transmission which may result in neonatal hepatitis. (hindawi.com)
- Occult hepatitis B infections are becoming a major global threat, but the available data on its prevalence in various parts of the world are often divergent. (ajol.info)
- The others are hepatitis A, C, D, and E. Most hepatitis infections are caused by these 5 viruses. (vidanthealth.com)
- The symptoms of all 5 hepatitis infections are much the same. (vidanthealth.com)
- Percentage of HBeAg-positive subjects detected using the hepatitis sAg/eAg test versus the PEI HBeAg standard. (asm.org)
- Reactive Hepatitis B Surface Antigen will reflex to the Hepatitis B Surface Antigen Confirmatory neutralization test for an additional charge. (legacyhealth.org)
- To test the efficacy of daily lamivudine in preventing and treating hepatitis B reactivation and in circumventing hepatic failure and death. (clinicaltrials.gov)
Serum hepatitis B vir1
- In four of 12 instances, transient elevations in ALT levels were associated with a fall in serum hepatitis B virus DNA levels. (nih.gov)
- The hepatitis B binding substance found in animals is not antibody, but appears to be a glycoprotein which reacted with antigen-coated beads and produced a "false positive" test for antibody. (asm.org)
- This glycoprotein could be selectively and quantitatively removed by reaction with purified hepatitis B surface antigen and centrifugation. (asm.org)
- New immunization strategies have been developed to eliminate the spread of HBV and hepatitis A virus (HAV) in the United States. (cdc.gov)
- Practices (ACIP), is the introduction of study carried out from February 2003 to hepatitis B immunization at birth [ 5,6 ]. (who.int)
- These results demonstrate the potential use of a full-length antigen to be displayed on phages as cost effective adjuvant-free immunization agents as an alternative to the highly purified and more expensive antigens conjugated with carrier molecules. (ku.edu)
- The results demonstrate the applicability of biodegradable microspheres for immunization against hepatitis B. (pda.org)
- Monospecific, reacts only with Hepatitis B virus. (genetex.com)
- HLA-B27 is a human leukocyte antigen that helps the body differentiate its own cells from foreign substances. (reference.com)
- Recombinant hepatitis B surface antigen of ayw subtype. (genetex.com)
- Normal results are negative or nonreactive, meaning that no hepatitis B surface antigen was found. (vidanthealth.com)