The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion.
Antibodies to the HEPATITIS B ANTIGENS, including antibodies to the surface (Australia) and core of the Dane particle and those to the "e" antigens.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.
A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic hepatitis B, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins G.
Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.
INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Immunoglobulins raised by any form of viral hepatitis; some of these antibodies are used to diagnose the specific kind of hepatitis.
INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
INFLAMMATION of the LIVER in humans caused by a member of the HEPATOVIRUS genus, HUMAN HEPATITIS A VIRUS. It can be transmitted through fecal contamination of food or water.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Sites on an antigen that interact with specific antibodies.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).
Antigens of the virions of HEPACIVIRUS, their surface, core, or other associated antigens.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Substances that are recognized by the immune system and induce an immune reaction.
A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
Proteins found mainly in icosahedral DNA and RNA viruses. They consist of proteins directly associated with the nucleic acid inside the NUCLEOCAPSID.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.
INFLAMMATION of the LIVER.
Disease having a short and relatively severe course.
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Any of the viruses that cause inflammation of the liver. They include both DNA and RNA viruses as well viruses from humans and animals.
A DNA virus that closely resembles human hepatitis B virus. It has been recovered from naturally infected ducks.
A species in the genus HEPATOVIRUS containing one serotype and two strains: HUMAN HEPATITIS A VIRUS and Simian hepatitis A virus causing hepatitis in humans (HEPATITIS A) and primates, respectively.
The transference of a part of or an entire liver from one human or animal to another.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
INFLAMMATION of the LIVER in animals due to viral infection.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Substances elaborated by viruses that have antigenic activity.
Any vaccine raised against any virus or viral derivative that causes hepatitis.
Substances elaborated by bacteria that have antigenic activity.
Tumors or cancer of the LIVER.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Vaccines or candidate vaccines used to prevent infection with hepatitis A virus (HEPATOVIRUS).
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.

Complement fixing hepatitis B core antigen immune complexes in the liver of patients with HBs antigen positive chronic disease. (1/729)

One hundred and fifty-two biopsies from serologically HBsAg positive and negative patients with liver disease were studied in immunofluorescence: for the presence of the surface (HBs) and the core (HBc) antigenic determinants foeterminants of the hepatitis B virus, of immunoglobulins and complement (C) deposits, and for the capacity to fix human C. Circumstantial evidence is presented suggesting that HBc immune-complexes are a relevant feature in the establishment and progression of chronic HBSAg liver disease. C fixation by liver cells was shown in all HBC positive patients with chronic hepatitis; an active form was present in every case, except two with a persistent hepatitis, an inverse ratio of HBc to C binding fluorescence being noted between active chronic hepatitis and cirrhotic patients. HBc without C fixation was observed in only three patients in the incubation phase of infectious hepatitis. IgG deposits were often found in HBc containing, C fixing nuclei. No C binding or IgG deposits were observed in acute self-limited type B hepatitis, in serologically positive patients with normal liver or minimal histological lesions, with and without HBs cytoplasmic fluorescence in their biopsy, or in serologically negative individuals.  (+info)

Native display of complete foreign protein domains on the surface of hepatitis B virus capsids. (2/729)

The nucleocapsid of hepatitis B virus (HBV), or HBcAg, is a highly symmetric structure formed by multiple dimers of a single core protein that contains potent T helper epitopes in its 183-aa sequence. Both factors make HBcAg an unusually strong immunogen and an attractive candidate as a carrier for foreign epitopes. The immunodominant c/e1 epitope on the capsid has been suggested as a superior location to convey high immunogenicity to a heterologous sequence. Because of its central position, however, any c/e1 insert disrupts the core protein's primary sequence; hence, only peptides, or rather small protein fragments seemed to be compatible with particle formation. According to recent structural data, the epitope is located at the tips of prominent surface spikes formed by the very stable dimer interfaces. We therefore reasoned that much larger inserts might be tolerated, provided the individual parts of a corresponding fusion protein could fold independently. Using the green fluorescent protein (GFP) as a model insert, we show that the chimeric protein efficiently forms fluorescent particles; hence, all of its structurally important parts must be properly folded. We also demonstrate that the GFP domains are surface-exposed and that the chimeric particles elicit a potent humoral response against native GFP. Hence, proteins of at least up to 238 aa can be natively displayed on the surface of HBV core particles. Such chimeras may not only be useful as vaccines but may also open the way for high resolution structural analyses of nonassembling proteins by electron microscopy.  (+info)

Phosphorylation-dependent binding of hepatitis B virus core particles to the nuclear pore complex. (3/729)

Although many viruses replicate in the nucleus, little is known about the processes involved in the nuclear import of viral genomes. We show here that in vitro generated core particles of human hepatitis B virus bind to nuclear pore complexes (NPCs) in digitonin-permeabilized mammalian cells. This only occurred if the cores contained phosphorylated core proteins. Binding was inhibited by wheat germ agglutinin, by antinuclear pore complex antibodies, and by peptides corresponding either to classical nuclear localization signals (NLS) or to COOH-terminal sequences of the core protein. Binding was dependent on the nuclear transport factors importins (karyopherins) alpha and beta. The results suggested that phosphorylation induces exposure of NLS in the COOH-terminal portion of the core protein that allows core binding to the NPCs by the importin- (karyopherin-) mediated pathway. Thus, phosphorylation of the core protein emerged as an important step in the viral replication cycle necessary for transport of the viral genome to the nucleus.  (+info)

Viral clearance without destruction of infected cells during acute HBV infection. (4/729)

Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the destruction of infected hepatocytes by CD8(+) T lymphocytes. However, in this study, HBV DNA was shown to largely disappear from the liver and the blood of acutely infected chimpanzees long before the peak of T cell infiltration and most of the liver disease. These results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.  (+info)

A recombinant measles virus expressing hepatitis B virus surface antigen induces humoral immune responses in genetically modified mice. (5/729)

It has been shown previously that measles virus (MV) can be successfully used to express foreign proteins (M. Singh and M. A. Billeter, J. Gen. Virol. 80:101-106, 1998). To develop an inexpensive MV-based vaccine, we generated recombinant MVs that produce structural proteins of hepatitis B virus (HBV). A recombinant virus that expressed the HBV small surface antigen (HBsAg) was analyzed in terms of its replication characteristics, its genetic stability in cell culture, and its immunogenic potential in genetically modified mice. Although this virus showed a progression of replication slightly slower than that of the parental MV, it appeared to stably maintain the added genetic information; it uniformly expressed the appropriately glycosylated HBsAg after 10 serial passages. Genetically modified mice inoculated with this recombinant MV produced humoral immune responses against both HBsAg and MV proteins.  (+info)

Detection of core antibody in hepatitis B infection. (6/729)

Hepatitis B core antigen (HBcAg) is found on the decoated Dane particle and on a morphologically similar particle detected mainly in the nucleus of hepatocytes of patients with hepatitis B. HBcAg prepared from the liver of a chimpanzee infected with hepatitis B virus was used to test human serum for core antibody (anti-HBc) by complement fixation. Anti-HBc was found in serum collected from patients with hepatitis B in both the acute and convalescent stages, from carriers of hepatitis B surface antigen (HBsAg) and from patients with chronic liver or renal disease who were carriers of HBsAg. It was not found in patients with hepatitis A or infectious mononucleosis, or in healthy persons who were not carriers of HBsAg.  (+info)

The mechanism of an immature secretion phenotype of a highly frequent naturally occurring missense mutation at codon 97 of human hepatitis B virus core antigen. (7/729)

A very frequent missense mutation at codon 97 of human hepatitis B virus (HBV) core antigen (HBcAg) has been found in chronic carriers worldwide. Functional characterization of this mutant revealed one intracellular and two extracellular phenotypes in contrast to wild-type HBV: (i) a 6- to 12-fold decrease in the level of the full-length relaxed circular DNA, a 4- to 5-fold decrease in the plus-strand DNA, and an approximately 1.8-fold decrease in the minus-strand and overall DNA levels in the intracellular viral core particles; (ii) a 5.7-fold increase in the immature secretion of Dane particles, containing minus-strand, single-stranded virion DNA; and (iii) a significant reduction of nonenveloped core particles in the medium. The steady-state levels of mutant and wild-type core proteins expressed from the same vector appeared to be similar. Using a complementation assay and gradient centrifugation analysis, we demonstrated that this mutant core protein alone is necessary and sufficient for immature secretion. The decreased level of intracellular HBV DNA is caused by both the cis defect of the mutant genome and the trans defect of the mutant core protein. We have dissected further the relationship between the intracellular and extracellular phenotypes of mutant F97L. The pleiotropic effects of the HBcAg codon 97 mutation were observed consistently in several different experimental settings. The mechanism and biological significance of these findings are discussed.  (+info)

Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. (8/729)

BACKGROUND: Hepatitis B virus (HBV) infections in patients who lack detectable hepatitis B surface antigen (HBsAg) are called occult infections. Although such infections have been identified in patients with chronic hepatitis C liver disease, their prevalence and clinical significance are not known. METHODS: With the polymerase chain reaction, we searched for HBV DNA in liver and serum samples from 200 HBsAg-negative patients with hepatitis C virus (HCV)-related liver disease (147 with chronic hepatitis, 48 with cirrhosis, and 5 with minimal histologic changes). One hundred of the patients had detectable antibodies to the HBV core antigen (anti-HBc); 100 were negative for all HBV markers. Eighty-three were treated with interferon alfa. We also studied 50 patients with liver disease who were negative both for HBsAg and for HCV markers. In six patients found to have occult HBV infection, we evaluated possible genomic rearrangements through cloning or direct sequencing procedures. RESULTS: Sixty-six of the 200 patients with chronic hepatitis C liver disease (33 percent) had HBV sequences, as did 7 of the 50 patients with liver disease unrelated to hepatitis C (14 percent, P=0.01). Among the 66 patients, 46 were anti-HBc-positive and 20 were negative for all HBV markers (P<0.001). Twenty-two of these 66 patients (33 percent) had cirrhosis, as compared with 26 of the 134 patients with hepatitis C infection but no HBV sequences (19 percent, P=0.04). HBV sequences were detected in 26 of the 55 patients in whom interferon therapy was ineffective and 7 of the 28 patients in whom interferon therapy was effective (P=0.06). None of the sequenced HBV genomes had changes known to interfere with viral activity and gene expression. CONCLUSIONS: Occult hepatitis B infection occurs frequently in patients with chronic hepatitis C liver disease and may have clinical significance.  (+info)

Mouse monoclonal antibody raised against recombinant hepatitis B virus core antigen Recombinant protein corresponding to hepatitis B virus core antigen core. (MAB5403) - Products - Abnova
Mouse monoclonal antibody raised against recombinant hepatitis B virus core antigen Recombinant protein corresponding to hepatitis B virus core antigen core. (MAB5402) - Products - Abnova
Recombinant Hepatitis B virus core antigen (HBcAg), amino acids 1-183.|br||br|Hepatitis B core antigen is an indicator of active viral replication. A patient infected with Hepatitis B testing positive…
References for Abcams Recombinant Hepatitis B Virus Core Antigen protein (ab119471). Please let us know if you have used this product in your publication
HBc IgM ELISA Screening, 96 wells (EIA4085) - An Enzyme ImmunoAssay (ELISA) for determination of IgM class antibodies to Hepatitis B Virus core Antigen in plasma and sera with the capture system.
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Hepatitis B Virus Core Antigen antibody [H6F5] for ELISA, WB. Anti-Hepatitis B Virus Core Antigen mAb (GTX22045) is tested in Hepatitis B virus samples. 100% Ab-Assurance.
Hepatitis B Virus Core Antigen antibody [H3A4] for ELISA, WB. Anti-Hepatitis B Virus Core Antigen mAb (GTX28255) is tested in Hepatitis B virus samples. 100% Ab-Assurance.
Read Non‐A, non‐b hepatitis virus: identification of a core antigen‐antibody system that cross reacts with hepatitis b core antigen and antibody, Journal of Medical Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Monoclonal Antibody to Hepatitis B Core Antigen (HBcAg), (ayw) (a.a. 1-10) N-terminal End [10E11], validated in WB, IHC, IP, EIA (AR11126), Abgent
The hepatitis B virus core (HBc) virus-like particle (VLP) is known as one of the most immunogenic antigens and carrier vehicles in different immunization strategies. Recent findings are suggesting the potential of the HBc VLPs as an oral immunogen. Here, we focus on the induction of serum humoral responses by oral administration of HBc VLPs in preparations substantially free of lipopolysaccharide and immunomodulating encapsidated RNA. The full-length HBc antigen was used, because the C-terminal arginine-rich tail may contribute to the immunogenicity of the antigen as the region is involved in cell surface heparan sulfate binding and internalization of the protein. Serum antibody levels and isotypes were determined following oral administration of the HBc VLPs with the perspective of using the HBc VLP as an immunostimulatory and carrier molecule for epitopes of blood-borne diseases in oral immunization vaccination strategies. Following oral administration of the HBc VLP preparations to mice, a strong
Hepatitis B core antibodies appear shortly after the onset of symptoms of hepatitis B infection and soon after the appearance of HBsAg and persists for life. Initially, anti-HBcAb consists... ...
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New double staining technology allows for easier staining protocols and faster turnaround time. The cocktail approach can be used when two primary antibodies are from different host species, as is the example of these two antibodies (mouse monoclonal antibody against HBsAg and rabbit polyclonal antibody against HBcAg). A secondary antibody or detection system can also be a cocktail of horseradish peroxidase (HRP) labeled anti-rabbit and alkaline phosphatase (AP) labeled anti-mouse. This allows simultaneous incubation of both primary antibodies, followed by simultaneous incubation of the cocktailed secondary detection reagents. This is a huge time saver compared to sequential staining techniques. The only sequential step in the cocktail approach is the application of DAB chromogen followed by application of fast red (FR) chromogen ...
The page below is a sample from the LabCE course Liver Biopsies: Anatomy and Histological Considerations. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online ...
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CORAB : Patient Preparation: For 24 hours before this test do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins. Collection Container/Tube: Serum gel Submission Container/Tube: Plastic vial Specimen Volume: 1 mL Collection Instructions: Spin down and remove serum from clot within 24 hours.
anti-HAV, antibody to HAV (IgM and IgG subclasses); anti-HAV-IgG, IgG class antibody to HAV; anti-HAV-IgM, IgM class antibody to HAV; anti-HBc, antibody to HBcAg; anti-HBc-IgG, IgG class antibody to HBcAg; anti-HBc-IgM, IGM class antibody to HBcAg; anti-HBe, antibody to HBeAg; anti-HBs, antibody to HBsAg; anti-HCV, antibody to hepatitis C; HBeAg, hepatitis B e antigen; HBcAg, hepatitis B core antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HCV, hepatitis C virus; IgM and IgG, immunoglobulins M and G. ...
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Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS ...
Abstract. To assess the epidemiology of hepatitis B virus (HBV) infection among men who have sex with men (MSM) in Peru, we evaluated the prevalence and associated risk factors for HBV serologic markers among participants of a HIV sentinel surveillance conducted in 2002-2003. The standardized prevalences for total antibodies to hepatitis B core antigen (anti-HBc) and hepatitis B surface antigen (HBsAg) were 20.2% and 2.8%, respectively. Individuals with human immunodeficiency virus (HIV-1) infection had significantly higher anti-HBc (44.3% versus 19.3%) and HBsAg (9.5% versus 2.3%) prevalences than uninfected men. Increasing age (adjusted odds ratio [AOR] = 1.06), versatile sexual role (AOR = 1.59), sex in exchange for money/gifts (AOR = 1.58), syphilis (AOR = 1.74), HIV-1 infection (AOR = 1.64), and herpes simplex virus type 2 (HSV-2, AOR = 2.77) infection were independently associated with anti-HBc positivity, whereas only HIV-1 infection (AOR = 3.51) and generalized lymph node enlargement (AOR = 3.72
The prevalence of the Hepatitis B core antigen (anti-HBc)in the Thai population is about 70 %. No data of isolated anti-HBc is reported. Anti-HBc antigen is observed in 10%-20% of individuals from low endemic areas of HBV infection. The prevalence of isolated antiHBc antigen is expected to be higher in endemic areas of HBV infection. There is conflicting data of occult HBV infection in HIV-infected patients. In Thailand, perinatal transmission is the main route of HBV transmission, different from developed countries. Therefore, isolated anti-HBc in Thai people has longer duration than low prevalence regions. Moreover, HBV genotype C and B is common in this region. HBV genotype C is correlated with more cirrhosis and hepatoma than genotype B. A study from Taiwan demonstrated that HBV DNA , 100,000 copies/ml is correlated with cirrhosis and hepatoma. Sustained reduction of HBV replication lowers the risk of hepatoma in HBV related cirrhosis. If the HBV vaccination could eliminate an occult HBV ...
The team assessd 872 patients with chronic Hepatitis C virus infection, of which 597 had chronic Hepatitis, and 275 had cirrhosis.. The research team measured incidence of hepatocellular carcinoma on follow-up from 1995 to 2005.. Only 846 of the 872 enrolled patients were followed up.. The team found that hepatocellular carcinoma occurred in 28% of patients.. Among patients with cirrhosis, hepatocellular carcinoma was diagnosed in 60% with anti-Hepatitis B core antigen.. The researchers noted that hepatocellular carcinoma was diagnosed in 45% without Hepatitis B virus-related serologic markers.. Of 224 patients with chronic hepatitis who had interferon monotherapy, 41% had sustained or transient disappearance of Hepatitis C virus RNA.. None of the anti-Hepatitis B core antigen-negative patients who had a virologic response to interferon therapy developed hepatocellular carcinoma.. The researchers observed that cancer was diagnosed in 4 of 37 anti-Hepatitis B core antigen -positive patients with ...
AIM: To investigate whether hepatitis B disease (HBV) could induce a hepatitis B disease core antigen (HBcAg)-specific cytotoxic T lymphocyte (CTL) response in vitro by dendritic cells (DCs) transduced with lentiviral vector-encoding ubiquitinated hepatitis B disease core antigen (LV-Ub-HBcAg). major histocompatibility class II. DCs sensitised by different LVs efficiently advertised cytokine secretion; the levels of IL-2 and interferon- induced by LV-Ub-HBcAg were higher than those induced by LV-HBcAg. Compared with LV-HBcAg-transduced DCs, LV-Ub-HBcAg-transduced DCs more efficiently stimulated the proliferation of T lymphocytes and generated HBcAg-specific cytotoxic T lymphocytes. Summary: LV-Ub-HBcAg efficiently induced DC maturation. The adult DCs efficiently induced T cell polarisation to Th1 and generated HBcAg-specific CTLs. antigen ESAT-6 DNA vaccine increased the antigen-specific cellular immune system response in BALB/c mice significantly. That study verified which the Th1-type immune ...
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Willie T.C., Chakrapani, V., White Hughto, J.M., Kershaw, T.S. (2017) Victimization and Human Immunodeficiency Virus-Related Risk Among Transgender Women in India: A Latent Profile Analysis., Violence and Gender, Dec 1;4(4):121-129. doi: 10.1089/vio.2017.0030.. Dubov, A., Fraenkel, L., Yorick, R., Ogunbajo, A., Altice, F.L. (2017) Strategies to Implement Pre-exposure Prophylaxis with Men Who Have Sex with Men in Ukraine., AIDS and Behavior, Dec 6. doi: 10.1007/s10461-017-1996-y. [Epub ahead of print]. Noroozi, M., Marshall, B.D.L., Noroozi, A., Armoon, B., Sharifi, H., Farhoudian, A., Ghiasvand, H., Vameghi, M., Rezaei, O., Sayadnasiri, M., Pouya, R.H. (2017) Do needle and syringe programs reduce risky behaviours among people who inject drugs in Kermanshah City, Iran? A coarsened exact matching approach., Drug and Alcohol Review, Dec 21. doi: 10.1111/dar.12646. [Epub ahead of print]. Wu, J., Crawford, F.W., Raag, M., Heimer, R., Uusküla, A., (2017) Using data from respondent-driven ...
Serum: Allow to clot. Centrifuge at 3380 rpms (±100) for a minimum of 10 minutes. Centrifuge within 2 hours of collection.. ...
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Hepatitis B virus (HBV) infections represent a global health problem, since these account for 350 million chronic infections worldwide that result in 500 000-700 000 deaths each year. Control of viral replication and HBV-related disease and mortality are of utmost importance. Because the currently available antiviral therapies all have major limitations, new strategies to treat chronic HBV infection are eagerly awaited. Six single-domain antibodies (VHHs) targeting the core antigen of HBV (HBcAg) have been generated and three of these bound strongly to HBcAg of both subtype ayw and adw. These three VHHs were studied as intrabodies directed towards the nucleus or the cytoplasm of a hepatoma cell line that was co-transfected with HBV. A speckled staining of HBcAg was observed in the cytoplasm of cells transfected with nucleotropic VHH intrabodies. Moreover, an increased intracellular accumulation of hepatitis B e antigen (HBeAg) and a complete disappearance of intracellular HBcAg signal were observed with
Key Points - HepadnavirusKey VirusesHepatitis B virus (HBV)CharacteristicsDNA virusReplicates in nucleusReplicates using reverse transcriptasePartially double-standed DNA → polymerase completes dsDNA → transcription into RNA template (used to make viral proteins) → reverse transcription into dsDNA progenyNucleocapsid core contains hepatitis B core antigen, HBcAgEnvelopedLipoprotein envelope surrounds nucleocapsid coreContains hepatitis B surface antigen, HBsAg and envelope antigen, HBeAgCircular chromosomeTransmissionMany routesBlood (transfusion, IVDU, shared needles)Sexual contactPerinatalTransplantPathogenesisMigrates to liver and replicates in hepatocytesCauses immune-mediated damage by CD8+ T-cells and NK cellsNo direct cytotoxic effect of virusCD8+ T-cells recognize HBsAg and HBcAg presented on MHCI of hepatocytesPresentationAcute hepatitisFever, jaundice, elevated ALT and AST (ALT | AST)Most cases are acute and will undergo complete resolution (|95%)Chronic hepatitis occurs in 4-5% of
Results n=225 patients were identified who commenced treatment with either infliximab (IFX, n=144) or adalimumab (ADA, n=81) for treatment of inflammatory bowel disease in a 3 years period from 2010 to 2012. 65% of patients had Crohns disease, 30% had ulcerative colitis and 5% had IBD-U, undetermined. The proportion of patient who had evidence of screening for Hepatitis B using surface antigen testing (HBsAg) increased significantly from 23% in 2010 to 82% in 2012. However, even in 2012, only 12.5% had antibodies to Hepatitis B core antigen (HBcAb) measured. No patient had a positive HBsAg but 1/13 patients tested had a positive HBcAb. The frequency of screening for latent TB using the quantiferon release assay (QFT) increased from 5% in 2010 to 74% in 2012. 1/64 (1.6%) of the QFT tests was positive resulting treatment for latent TB. One patient who had not undergone QFT testing developed active TB on IFX treatment.. ...
Hepatitis B core antigen (HBcore) can self-assemble into VLP (virus-like particles) when it is produced in plants and it has shown to be an attractive carrier for presentation of foreign epitopes for the development of subunit vaccines. The small and critical dengue virus domain III of envelope protein (DVd3) contains multiple serotype-speci﫿c neutralizing epitopes. However, previous work showed that mice immunized with plant-made DVd3 protein without adjuvant elicited low immune responses. In order to produce a candidate for subunit vaccines and to avoid low immune responses in the corresponding pre-clinical studies, DVd3 was fused to HBcore and introduced into tobacco plant cells using deconstructed viral vectors. DVd3 and HBcore antigens were linked by a 﫿exible linker peptide and co-infiltrated in Nicotiana benthamiana plants with 5 Module and Integrase Module. HBcore-DVd3 was produced successfully in N. benthamiana plants (0.43 mg/g fresh weight or 2.23% of total soluble protein) and ...
The E.coli derived recombinant multimer protein contains the HCV core nucleocapsid immunodominant regions, amino acids 2-119. The protein is fused to a GST tag at N-terminus.
Hepatitis B tests may be used for a variety of reasons. Some of the tests detect antibodies produced in response to HBV infection; some detect antigens produced by the virus, and others detect viral DNA.Generally, one set of tests is used to determine the cause of acute symptoms while another set of tests may be used after a diagnosis is made, to monitor possible progression of the disorder, to detect chronic infection and/or carrier status.Medical Tests Analyzer labtest bloodtest What does the test result mean?
TY - JOUR. T1 - Immunity targeting common core antigens of gram-negative bacteria.. AU - Tyler, J. W.. AU - Cullor, James S. AU - Spier, Sharon. AU - Smith, Bradford. PY - 1990/1. Y1 - 1990/1. N2 - Antibodies against common gram-negative core antigens can provide protection against environmental, commensual, and contagious bacteria that cause life-threatening gram-negative sepsis/endotoxemia. Cross-protective immunity may be effective against many common livestock diseases, including neonatal coliform septicemia, coliform mastitis, septic metritis, and severe enteritis. The greatest potential benefit of cross-protective immunity may be realized in the reduction of ill-thrift and mortality of neonates. The use of active and passive immunization against core antigens common to gram-negative bacteria has been successful in human beings, laboratory animals, and livestock. Protection has been observed following challenge with either heterologous endotoxin or unrelated, live, virulent gram-negative ...
You ask good questions. 1. Usually, HBVDNA is not detected if HBV sAg is negative. The only situation I have seen this is in someone with isolated Hepatitis B core antibody positivity. This is very...
Figure 9. Image from http://www-immuno.path.cam.ac.uk/~immuno/part1/lec08/lec8_97.html. CD4+ T cell Response. Activated HBV-specific CD4+ T cells are multispecific. However, strong helper T cell responses are found against certain peptides in both the HBcAg and HBeAg following resolution of acute HBV infection. While HBeAg has been shown to induce a Th2 immune response, HBcAg stimulated a Th1 response. Additionally, CD4+ T cell responses are detected against polymerase and X antigens (Chang and Lewin, 2007). Because the Th2 response to HBeAg was dominant to the Th1 response to the HBcAg, the HBcAg-specific T cells were depleted in vivo (Huang et. al., 2006). It is important that both Th1 and Th2 responses are generated because they induce different responses. While the Th1 cells stimulate macrophages, which can clear virus particles, the Th2 cells stimulate humoral immunity, in which B cells are stimulated to generate immunoglobulins for opsonization. However, different doses of virus seem to ...
clearly defined process for enrolment of altruistic donors was made available to interested participating units and a pathway for hepatitis B core antibody positive donors as well as the corresponding matching option in NOMS have been developed and will be available from the ...
PepTivator® HCV1b Core - research grade is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the complete sequence of the human HC virus (HCV) 1b core protein (UniProt ID: P26663 [aa1-191].In vitro stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells. - Österreich
Vīrusveidīgo daļiņu, jeb t.s. VLP (virus-like particles) proteīnu inženierijas idejas pieteikšana un tās pamatu izveidošana (kopā ar E. Grēnu). Vīrusu proteīnu imunoloģisko epitopu kartēšana (kopā ar P. Puško un I. Sominsku). Proteīnu inženierijas VLP vektoru, jeb nesēju, radīšana; himēro VLP konstruēšana uz to pamata. HBcAg izveidošana par universālu VLP nesēju - tradicionālāko himēro VLP struktūru pamatu; svešu epitopu iebūvēšana HBcAg struktūrā - no HIV, HBV, HCV, FMDV un daudziem citiem vīrusu un nevīrusu izcelsmes proteīniem (kopā ar G. Borisovu, I. Sominsku, A. Dišleru, I. Petrovski, A. Kazāku, K. Sasnausku, R. Ulrichu, H. Meiseli u. c.). HBcAg telpiskās struktūras atšifrēšana (kopā ar R. A. Krovčeru (R. A. Crowther), N. Kiseļevu, E. Grēnu u. c.). HBcAg pakojošo īpašību atšifrēšana un izmantošana (kopā ar M. Bahmanu (M. Bachmann) un A.Kazāku). HBcAg imunoloģisko īpašību atšifrēšana (kopā ar R. M. Cinkernāgelu (R. M. ...
Vīrusveidīgo daļiņu, jeb t.s. VLP (virus-like particles) proteīnu inženierijas idejas pieteikšana un tās pamatu izveidošana (kopā ar E. Grēnu). Vīrusu proteīnu imunoloģisko epitopu kartēšana (kopā ar P. Puško un I. Sominsku). Proteīnu inženierijas VLP vektoru, jeb nesēju, radīšana; himēro VLP konstruēšana uz to pamata. HBcAg izveidošana par universālu VLP nesēju - tradicionālāko himēro VLP struktūru pamatu; svešu epitopu iebūvēšana HBcAg struktūrā - no HIV, HBV, HCV, FMDV un daudziem citiem vīrusu un nevīrusu izcelsmes proteīniem (kopā ar G. Borisovu, I. Sominsku, A. Dišleru, I. Petrovski, A. Kazāku, K. Sasnausku, R. Ulrichu, H. Meiseli u. c.). HBcAg telpiskās struktūras atšifrēšana (kopā ar R. A. Krovčeru (R. A. Crowther), N. Kiseļevu, E. Grēnu u. c.). HBcAg pakojošo īpašību atšifrēšana un izmantošana (kopā ar M. Bahmanu (M. Bachmann) un A.Kazāku). HBcAg imunoloģisko īpašību atšifrēšana (kopā ar R. M. Cinkernāgelu (R. M. ...
We are all believers in the miracles of modern medicine. We like to assume that all problems associated with infant mortality will just go away....
TY - JOUR. T1 - The use of hepatitis B core antibody-positive donor livers does not appear to have a deleterious effect on graft survival in liver transplantation for hepatitis C. AU - Rayhill, S.. AU - Schwartz, Jonathan M.. AU - Ham, J.. AU - Carithers, R.. AU - Lei, Y.. AU - Bhattacharya, R.. AU - Liou, I.. AU - Landis, C.. AU - Lamaye, A.. AU - Rakita, R.. AU - Dick, A.. AU - Healey, P.. AU - Halldorson, J.. AU - Bhakthavatsalam, R.. AU - Perkins, J.. AU - Reyes, J.. PY - 2010/12. Y1 - 2010/12. N2 - Introduction The use of hepatitis B core antibody-positive donor livers (HBcAb +) has steadily increased. According to a recent multivariate analysis of United Network for Organ Sharing (UNOS) data, there was no significant increase in the risk of using these donors. The increased risk among the hepatitis C virus (HCV)-positive subgroup noted in a univariate model disappeared upon multivariate analysis. However, deeper scrutiny may show that HCV-positive recipients may be at increased risk with ...
Prieto M, Gomez MD, Berenguer M, Cordoba J, Rayon JM, Pastor M, Garcia-Herola A, et al. De novo hepatitis B after liver transplantation from hepatitis B core antibody-positive donors in an area with high prevalence of anti-HBc positivity in the donor population. Liver Transpl 2001; 7:51-58 ...
The seroprevalence and incidence of hepatitis A, B, C, and E virus infection were determined among North American missionaries (n = 328) serving in various geographic locations between 1967 and 1984. The mean age of subjects at entry into the study was 39.7 years (range 5-73 years); 65% were female: 89% had lived outside the United States before the study began. Seventy-eight percent of subjects served in sub-Saharan Africa during the study. At initial evaluation, 50.9% of the subjects had antibodies to hepatitis A virus (total anti-HAV), 8.5% to hepatitis B virus core antigen (total anti-HBc), 0.6% to hepatitis C virus (total anti-HCV by second- generation immunoblot assay), and 0% to hepatitis E virus (IgG anti-HEV). After an average period of service of 7.3 years (2,396 person-years total), 5.8% of the missionaries seroconverted to anti-HAV, 5.5% to anti-HBc, 0.6% to anti-HCV, and 0% to anti-HEV. This study indicates a relatively low risk of hepatitis C and E virus infection among ...
Abstract The seroprevalence and incidence of hepatitis A, B, C, and E virus infection were determined among North American missionaries (n = 328) serving in various geographic locations between 1967 and 1984. The mean age of subjects at entry into the study was 39.7 years (range 5-73 years); 65% were female; 89% had lived outside the United States before the study began. Seventy-eight percent of subjects served in sub-Saharan Africa during the study. At initial evaluation, 50.9% of the subjects had antibodies to hepatitis A virus (total anti-HAV), 8.5% to hepatitis B virus core antigen (total anti-HBc), 0.6% to hepatitis C virus (total anti-HCV by second-generation immunoblot assay), and 0% to hepatitis E virus (IgG anti-HEV). After an average period of service of 7.3 years (2,396 person-years total), 5.8% of the missionaries seroconverted to anti-HAV, 5.5% to anti-HBc, 0.6% to anti-HCV, and 0% to anti-HEV. This study indicates a relatively low risk of hepatitis C and E virus infection among
TY - JOUR. T1 - Lack of susceptibility of baboons to infection with hepatitis B virus. AU - Michaels, Marian G.. AU - Lanford, Robert. AU - Demetris, Anthony J.. AU - Chavez, Deborah. AU - Brasky, Kathleen. AU - Fung, John. AU - Starzl, Thomas E.. PY - 1996/2/15. Y1 - 1996/2/15. N2 - Historically, hepatitis B virus (HBV) has been considered species specific and unable to infect baboons. Based on this premise, two patients with HBV end-stage liver disease underwent baboon liver xenotransplantation. To study whether baboons are susceptible to HBV infection, four baboons (two receiving immunosuppressive therapy) were inoculated with HBV. Animals were followed for 6 months: clinical examinations and biochemical studies were normal, hepatitis B surface antigen and hepatitis B core antigen staining of biopsies was negative, and HBV serology remained negative. HBV polymerase chain reaction was transiently positive in one animal, which most likely reflects the initial inoculation. This pilot study ...
Between December 1990 and August 1998, 19 patients with acute hepatitis B were admitted to our institution. A diagnosis of acute hepatitis B was based on elevated serum alanine aminotransferase activity, detection of HBsAg and immunoglobulin M antibody to hepatitis B core antigen (anti-HBc) in the serum, and the recent onset of jaundice and other typical symptoms. Coinfection with hepatitis A, C, D, or E; Epstein-Barr virus; or cytomegalovirus was ruled out because of the negative results of serologic tests. Confounding etiology of liver disease, human immunodeficiency virus infection, and other immunodeficient diseases were not found in any patient. In 2000, this complete series of patients with acute hepatitis B was contacted for follow-up. Fourteen patients (74%) revisited our institution and were reevaluated for clinical, serologic, histologic, and virologic recovery from the disease. The group comprised 11 men and 3 women ranging in age from 26 to 65 years (median, 43 years). All patients ...
Hepatitis B virus (HBV) core protein (HBc) can shuttle between nucleus and cytoplasm. Cytoplasm-predominant HBc is clinically associated with severe liver inflammation. Previously, we found that HBc arginine-rich domain (ARD) can associate with a host factor NXF1 (TAP) by coimmunoprecipitation. It is well known that NXF1-p15 heterodimer can serve as a major export receptor of nuclear mRNA as a ribonucleoprotein complex (RNP). In the NXF1-p15 pathway, TREX (transcription/export) complex plays an important role in coupling nuclear pre-mRNA processing with mRNA export in mammalian cells. Here, we tested the hypothesis whether HBc and HBV specific RNA can be exported via the TREX and NXF1-p15 mediated pathway. We demonstrated here that HBc can physically and specifically associate with TREX components, and the NXF1-p15 export receptor by coimmunoprecipitation. Accumulation of HBc protein in the nucleus can be induced by the interference with TREX and NXF1-p15 mediated RNA export machinery. HBV transcripts
Protective measures against occupational exposure to the hepatitis B virus (HBV) and hepatitis C virus (HCV) must be taken in order to prevent infection in dental care workers. To determine the best way to protect these workers, our study examined viral hepatitis infection in dental care workers in regions with a high prevalence of HCV infections in Japan. In total, 141 dental care workers (including dentists, dental hygienists and dental assistants) were enrolled. After a questionnaire to elicit demographic information was administered by an oral surgeon, hepatitis B surface antigen (HBsAg), antibody to HBs (anti-HBs), antibody to hepatitis B core antigen (anti-HBc) and antibody to HCV (anti-HCV) were measured. When necessary, HBeAg, anti-HBe, levels of HBV DNA, anti-HBc IgM and HCV RNA in serum were measured. Of the dental care workers included, 68 (48.2%) had been immunized with a HBV vaccine. Only 9 wore a new pair of gloves for each new patient being treated, 36 changed to a new pair only ...
Reactive Hepatitis B Surface Antigen will reflex to the Hepatitis B Surface Antigen Confirmatory neutralization test for an additional charge. Reactive Hepatitis B Core Antibody will reflex to the Hepatitis B Core IgM antibody for an additional charge ...
Sedate the patient undergoing an aortic occlusion balloon allows for easier breathing, and circulation is commercial xm viagra the prototype virus and is essentially pressure support briggs t piece (rarely used) procedure 564 625 606 procedure guidelines 19-2 using balloon tamponade in north america and western europe, whereas hepatitis b core antigen (antigenic material in the midline. Nasogastric tube feedings and who is discharged from the ultrasound. Reconstruction with radial forearm free flap rotated 190 degrees radially on its anterior border. 4. Myocardial involvementheart failure and death. (2013). Gender, ancestry, and life span considerations cancer is unknown, although ionizing radiation at higher risk. If chronic diarrhea, bloody diarrhea, or constipation. In addition to health care team is indicated. 8 cm; usually unilateral. Hematemesis. Although too risky in a monobloc fashion, focal trauma is a factor. The consensus formula (formerly known as lou gehrig disease after infected ...
Positive for human immunodeficiency virus type 1 or 2 (HIV-1, HIV-2); hepatitis B; hepatitis C; human T lymphotrophic virus 1 (HTLV-1). (Note that subjects who have been vaccinated against hepatitis B [hepatitis B surface antibody-positive] who are negative for other markers of prior hepatitis B infection [eg, negative for hepatitis B core antibody (Ab)] are eligible. Subjects with past exposure to HBV [HBcAb positive and/or HBeAb positive] are also eligible for the study provided they have a negative test for HBV DNA. Also note that subjects who are positive for anti-hepatitis C antibody are eligible as long as they have a negative hepatitis C viral load ...
In order to estimate the prevalence of serological markers of exposure to Hepatitis B Virus (HBV), 295 subjects were selected at random from the National Registry of human immunodeficiency virus positive subjects. Evidence of exposure to HBV was defined as: testing Hepatitis B surface antigen (HBsAg) and anti-Hepatitis B core antigen (anti-HBc) positive or anti-HBc positive only. Overall, 133 (45.5%) were positive for anti-HBc and 15 (5.1%) resulted positive to HBsAg. Significant statistical association was found between male sex and exposure to HBV ( ...
HBCAG - What Does HBCAG Stand For? Definitions of Acronyms and Abbreviations at the Acronym Database. What Does HBCAG Mean? HBCAG Stands For ...
The core antigen (HBcAg) has been stained red by an immunohistochemical method. Note that most of the antigen is in hepatocyte nuclei, in contrast to surface antigen. The positive reaction indicates virus replication ...
... (core antigen) is a hepatitis B viral protein. It is an indicator of active viral replication; this means the person ... May 2003). "New enzyme immunoassay for detection of hepatitis B virus core antigen (HBcAg) and relation between levels of HBcAg ... HBcAg is an antigen that can be found on the surface of the nucleocapsid core (the inner most layer of the hepatitis B virus). ... "In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type ...
... after genetic immunization with retroviral vectors expressing different forms of the hepatitis B virus core and e antigens". ... The antigen-presenting cell then travels to the lymph nodes and presents the antigen peptide and costimulatory molecule ... This is true for intracellular and plasma membrane-bound antigens, but not for secreted antigens, which seem to generate TH2 ... Secreted or plasma membrane-bound antigens are more effective at inducing antibody responses than cytosolic antigens, while ...
Mamiya N, Worman HJ (May 1999). "Hepatitis C virus core protein binds to a DEAD box RNA helicase". The Journal of Biological ... "An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility ... This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in ... Owsianka AM, Patel AH (May 1999). "Hepatitis C virus core protein interacts with a human DEAD box protein DDX3". Virology. 257 ...
... is an antigen that can be found between the icosahedral nucleocapsid core and the lipid envelope (the outer most layer of ... HBeAg is a hepatitis B viral protein. It is an indicator of active viral replication; this means the person infected with ... The presence of HBeAg in the serum of patients can serve as a marker of active replication in chronic hepatitis. Although the ... "ORF Core" and "Pre C" are translated together, the result is HBeAg), HBeAg is secreted and accumulates in serum as an ...
"Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and ... In mice, a nonamer peptide originating from the SPP protein serves as minor histocompatibility antigen HM13 that plays a role ... SPP also plays a pathophysiological role; it cleaves the structural nucleocapsid protein (also known as core protein) of the ... Hepatitis C virus and thus influences viral reproduction rate. ...
... are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a ... Hep) moieties. The outer core oligosaccharide chain varies depending on the bacterial strain.[11][12] The term ... Core[edit]. Main article: Core oligosaccharide. The core domain always contains an oligosaccharide component that attaches ... O-antigen[edit]. A repetitive glycan polymer contained within an LPS is referred to as the O antigen, O polysaccharide, or O ...
... hepatitis B surface antigen, anti-hepatitis B core, and anti-hepatitis B surface). A person who has never been exposed to ... When a person gets a hepatitis B vaccine then the most common test for hepatitis B will show them to be positive. The usual ... "WHO , Hepatitis B". who.int. World Health Organization. 2011. Retrieved 7 July 2011. See the table "HBV serological markers in ... hepatitis B but has gotten the vaccine will be positive for anti-HBs but negative for the other two tests in the panel. Other ...
Hepatitis B: Two periods may be referred to as window period in hepatitis B infection: 1) the period that elapses during HBsAg ... During the window of HBsAg to HBsAb seroconversion, IgM anti-core (HBc-IgM) is the only detectable antibody. HBV DNA may be ... to HBsAb seroconversion, i.e. between the disappearance of surface antigen (HBsAg) from serum and the appearance of HBsAb (anti ... This window period does not occur in persons who develop chronic hepatitis B, i.e. who continue to have detectable HBV DNA for ...
McLauchlan J, Lemberg MK, Hope G, Martoglio B (2002). "Intramembrane proteolysis promotes trafficking of hepatitis C virus core ... The minor histocompatibility antigen 13 is a nonamer peptide that originates from a protein encoded by the H13 gene. The ... and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs ... Minor histocompatibility antigen H13 is a protein that in humans is encoded by the HM13 gene. ...
The icosahedral core particle is made of 180 or 240 copies of the core protein, alternatively known as hepatitis B core antigen ... "Predictive factors for reactivation of hepatitis B following hepatitis B e antigen seroconversion in chronic hepatitis B". ... Hepatitis D (HDV) can occur only with a concomitant hepatitis B infection, because HDV uses the HBV surface antigen to form a ... the HBsAg will become undetectable and will be followed by IgG antibodies to the hepatitis B surface antigen and core antigen ( ...
One effort involved using hepatitis B core antigen modified to carry a hepatitis C protein.[8] In a 2006 study, 60 patients ... "Development of hepatitis C virus vaccine using hepatitis B core antigen as immuno-carrier". World Journal of Gastroenterology. ... Although vaccines exist for hepatitis A and hepatitis B, development of a hepatitis C vaccine has presented challenges.[1] No ... Inovio is developing a synthetic multi-antigen DNA vaccine covering hepatitis C virus (HCV) genotypes 1a and 1b and targeting ...
Hepatitis B Surface Antigen Antibody to Hepatitis C Antibody to HIV, usually subtypes 1 and 2 Serologic test for Syphilis The ... Donated blood is tested by many methods, but the core tests recommended by the World Health Organization are these four: ... For example, the HIV antibody test will not detect a recently infected donor, so some blood banks use a p24 antigen or HIV ... The screening includes testing for diseases that can be transmitted by a blood transfusion, including HIV and viral hepatitis. ...
Immunoglobulin M antibody to hepatitis C virus core antigen: Correlations with viral replication, histological activity, and ... Improved serodiagnosis of hepaptis C virus Hepatitis C infection with synthetic peptide antigen from capsid protein. Proc Natl ... Patterns and prevalence of hepatitis type C infection in post-transfusion non-A, non-B hepatitis. J Inf Dis 1993; 167: 1296- ... Human lymphocyte bearing 1a-like antigens [now termed HLA-DK or class 1 MHC antigen]: Absence in patients with infantile ...
... such as the hepatitis B surface or core antigen), anti-viral antibodies (such as the anti-hepatitis B surface antibody or anti- ... Viral hepatitis is caused by five different viruses (hepatitis A, B, C, D, and E). Hepatitis A and hepatitis E behave similarly ... and are self-limiting illnesses that do not lead to chronic hepatitis. Hepatitis B, hepatitis C, and hepatitis D are ... hepatitis D is predominant among hepatitis B virus co-infected individuals. Similar to Hepatitis A, hepatitis E manifests as ...
The product of the X gene is hepatitis B x antigen (HBxAg). It may be involved in carcinogenesis. Basal core promoter mutants ... A precore mutant is a variety of hepatitis B virus that does not produce hepatitis B virus e antigen (HBeAg). These mutants are ... core promoter mutants limits the probability of response to peginterferon in hepatitis B e antigen-positive chronic hepatitis B ... They are readily detectable by HBV DNA in serum, but hepatitis B e antigen (HbeAg) is absent. The X gene codes for HBxAg. ...
... encoding the core antigen and pre-core protein which are processed and secreted as DHBcAg S-ORF - codes for the surface antigen ... is composed of the virus core antigen (DHBcAg) and surrounds the DNA genome and viral polymerase. The viral genome is a ... The Duck Hepatitis B virus has provided a basis for the use of vaccines and prophylactic treatments for individuals at high ... Duck Hepatitis B virus, abbreviated DHBV, is part of the Avihepadnavirus genus of the Hepadnaviridae, and is the causal agent ...
The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary ... The sera of these patients exhibit a characteristic "nuclear dots" pattern in indirect immunofluorescence (IIF) on Hep-2 cells ... Bolded areas represent the core epitope.) Szostecki C, Guldner HH, Netter HJ, Will H (1990). "Isolation and characterization of ... cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis ...
There are four known genes encoded by the genome called C, P, S, and X. The core protein is coded for by gene C (HBcAg), and ... The DNA polymerase is encoded by gene P. Gene S is the gene that codes for the surface antigen (HBsAg). The HBsAg gene is one ... Non primate species included the woodchuck hepatitis virus, the ground squirrel hepatitis virus and arctic squirrel hepatitis ... the Ground squirrel hepatitis virus, Woodchuck hepatitis virus, and the Woolly monkey hepatitis B virus. The genus is ...
Matched antibody pairs Anti-idiotypic Antibodies HBV Core Antigen Antibody Isotyping Kits Protein Antigen Expression Service ... "Molecular detection of hepatitis B virus (HBV) among voluntary ELISA positive blood donors in Almadinah Almunawwarah". Science ... Later, various kinds of antibody, viral antigens, reagents, medical kits and biological service were launched to broaden market ... "Human Bone Marrow Stromal Cell Antigen 1, BST1 ELISA Kit" (PDF). funakoshi. ...
The core of Transgene's discovery platform is gene transfer. This process requires vectors to deliver genes to the target cells ... The therapy is based on a recombinant vaccinia virus expressing the MUC1 antigen and the human cytokine, interleukin-2 (IL2). ... an immunotherapy product that is in Phase II clinical trials for the treatment of chronic hepatitis C infections (HCV); and ...
... hepatitis b antigens MeSH D23.050.327.495.500.450 --- Hepatitis B core antigens MeSH D23.050.327.495.500.469 --- hepatitis b e ... hepatitis c antigens MeSH D23.050.327.495.752 --- hepatitis delta antigens MeSH D23.050.327.520 --- hiv antigens MeSH D23.050. ... hepatitis antigens MeSH D23.050.327.495.249 --- hepatitis a antigens MeSH D23.050.327.495.500 --- ... hla-a antigens MeSH D23.050.301.500.450.370.372 --- hla-a1 antigen MeSH D23.050.301.500.450.370.374 --- hla-a2 antigen MeSH ...
Bat hepatitis virus Ground squirrel hepatitis virus Hepatitis B virus Woodchuck hepatitis virus Woolly monkey hepatitis B virus ... Four main open reading frames are encoded (ORFs) and the virus has four known genes which encode seven proteins: the core ... capsid protein, the viral polymerase, surface antigens-preS1, preS2, and S, the X protein and HBeAg. The X protein is thought ... Group: dsDNA-RT Order: Unassigned Family: Hepadnaviridae Genus: Avihepadnavirus Duck hepatitis B virus Heron hepatitis B virus ...
Hepatitis B virus DNA in patients with chronic liver disease and negative tests for hepatitis B surface antigen. N. Engl. J. ... Gut, 2005 Aug,54(8):1162-8. PAVIO N, BOUCREUX D, BATTAGLIA S, ARNULF B, SOBESKY R, HERMINE O, BRECHOT C. Hepatitis C virus core ... Distinct Hepatitis C Virus Core and F protein quasispecies in tumoral and nontumoral hepatocytes. Hepatology 2007 Dec;46(6): ... Hepatitis C virus core protein shows an exclusively cytoplasmic localization and associates to cellular lipid storage droplets ...
... hepatitis delta virus small delta antigen). p300/CBP have also been observed to acetylate β-catenin, RIP140, PCNA, the DNA ... The core region, which corresponds to motifs A, B, and D of the GNAT proteins, is flanked on opposite sides by N- and C- ... While the central core domain (motif A in GNATs) is involved in acetyl-CoA binding and catalysis, the N- and C-terminal ... The central core and the flanking segments together form a cleft over the former, which is where histone substrates can bind ...
The antigens of the anti-Sm antibodies are the core units of the small nuclear ribonucleoproteins (snRNPs), termed A to G, and ... Typically, HEp-2 cells are used as a substrate to detect the antibodies in human serum. Microscope slides are coated with HEp-2 ... Extractable nuclear antigens[edit]. Extractable nuclear antigens (ENA) are a group of autoantigens that were originally ... they will bind to antigens within the HEp-2 cell nucleus. These antibodies can be visualised by subsequent incubation with anti ...
... antigen - antigen presentation - antigen-presenting cell (APC) - antineoplastic - antiprotozoal - antiretroviral drugs - ... hepatitis - hepatitis C and HIV coinfection - hepatomegaly - herpes simplex virus 1 (HSV-1) - herpes simplex virus 2 (HSV-2) - ... core - core protein - correlates of immunity/correlates of protection - CPCRA - creatinine - cross-resistance - cryotherapy - ... human leukocyte antigens (HLA) - human papilloma virus (HPV) - human T cell lymphotropic virus type I (HTLV-I) - human T cell ...
... : at the core of cancer immunotherapy ". Nature Reviews Cancer. 14(2): 135-146. Van ... Hepatitis B (HBV) and C (HCV) viruses cause chronic inflammation which favors the appearance of hepatocarcinoma. The carcinoma ... In some patients, the majority of the tumor-specific T cells recognize mutated antigens. The contribution of these antigens to ... Cancer therapy targeted at tumor antigens can involve the direct use of these antigens in vaccines, but also the adoptive ...
The core of the complex has a ring structure consisting of six proteins that all belong to the same class of RNases, the RNase ... Targoff, IN; Reichlin, M (1985). "Nucleolar localization of the PM-Scl antigen". Arthritis & Rheumatism. 28 (2): 226-30. doi: ... In the past, the most commonly used methods were double immunodiffusion using calf thymus extracts, immunofluorescence on HEp-2 ... Both the core proteins of the exosome complex, as well as the two main associated proteins, are essential proteins.[34] ...
December 1993). "Human leukocyte antigen A1-B8-DR3-DQ2-DPB1*0401 extended haplotype in autoimmune hepatitis". Hepatology. 18 (6 ... In the US Caucasians, 57% of haplotypes with a core component, Cw7-B8, extend from HLA-A1 locus to DQ2 locus. This compares ... In autoimmune hepatitis[edit]. In 1972, a link between "HLA A1,8" (current:HLA A1-B8) active chronic hepatitis, subsequently B8 ... human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors". Hepatology. 13 (4): 701-6. doi:10.1002/hep.1840130415 ...
... antigen - antigen presentation - antigen-presenting cell (APC) - antineoplastic - antiprotozoal - antiretroviral drugs - ... hepatitis - hepatitis C and HIV coinfection - hepatomegaly - herpes simplex virus 1 (HSV-1) - herpes simplex virus 2 (HSV-2) - ... core - core protein - correlates of immunity/correlates of protection - creatinine - cross-resistance - cryotherapy - ... human leukocyte antigens (HLA) - human papilloma virus (HPV) - human T cell lymphotropic virus type I (HTLV-I) - human T cell ...
There is evidence that not only gliadin (main cytotoxic antigen of gluten), but also other proteins present in gluten and ... "Fad or fact -- gluten-free?". Core health. Retrieved 9 April 2016. Pomeroy, Ross. "Non-celiac gluten sensitivity may not exist ... autoimmune hepatitis, dermatitis herpetiformis, primary sclerosing cholangitis, and others. To evaluate the possible presence ...
"Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner". Traffic. 9 ... "Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame". RNA. 7 (5): 710-721. doi:10.1017/ ... Main article: Hepatitis C vaccine. Unlike hepatitis A and B, there is currently no vaccine to prevent hepatitis C infection.[60 ... Hepatitis. DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ...
Cells such as macrophages are specialists at this antigen presentation.[16]. Evading the immune systemEdit. Not all virus ... Viruses are able to cause many types of diseases, such as polio, ebola and hepatitis. Virology is the study of viruses. ... The genomic dsRNA remains protected inside the core of the virion.[11][12] ... Examples of the second type are the Hepadnaviridae, which includes Hepatitis B virus.[6]88/9. ...
interferon for hepatitis B e antigen-positive hepatitis B treatment: meta-analysis of randomized controlled trials. Liver ... Their genomic dsRNA remains protected inside the core of the virion.[187][188] ... Although hepatitis delta virus genome may replicate independently once inside a host cell, it requires the help of hepatitis B ... Development of vaccines against hepatitis A and hepatitis B. Reviews of Infectious Diseases. 1986;8(4):591-8. doi:10.1093/ ...
... tetapi juga hepatitis B dan hepatitis C. Berbagi penggunaan jarum suntik merupakan penyebab sepertiga dari semua infeksi baru ... Terdapat pula tes-tes komersial untuk mendeteksi antigen HIV lainnya, HIV-RNA, dan HIV-DNA, yang dapat digunakan untuk ... "Common at its core: HIV-related stigma across contexts" (PDF). International Center for Research on Women. Diakses tanggal ... Laurence J. (2006). "Hepatitis A and B virus immunization in HIV-infected persons". AIDS Reader. 16 (1): 15-17. PubMed.. ...
Human leukocyte antigen DR (especially DR3) appears to play a role.[10] To date, no clear genetic defect has been found to ... https://www.cambridge.org/core/journals/slavic-review/article/sophia-parnok-and-the-writing-of-a-lesbian-poets-life/ ... and cytotoxic T-lymphocyte-associated antigen 4, among others.[11] ... encountered has been explained by postulating that the thyroid gland and the extraocular muscles share a common antigen which ...
The IFNγ monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region.[14][15] This ... antigen processing and presentation. • positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity. • regulation of ... Hepatitis B (VII). *Nucleoside analogues/NARTIs: Entecavir#. *Lamivudine. *Telbivudine. *Clevudine. *Nucleotide analogues/ ... positive regulation of core promoter binding. • interleukin-12-mediated signaling pathway. • regulation of regulatory T cell ...
Specific genes that have been linked with MS include differences in the human leukocyte antigen (HLA) system-a group of genes ... core team' as many health services may be needed at different points in time.[5] Multidisciplinary rehabilitation programs ...
Malaria, yellow fever, viral hepatitis, leptospirosis[3]. Prevention. Dengue fever vaccine, decreasing mosquito exposure[1][4] ... Solomonides, Tony (2010). Healthgrid applications and core technologies : proceedings of HealthGrid 2010 ([Online-Ausg.]. ed ... viral antigen detection (such as for NS1) or specific antibodies (serology).[35][51] Virus isolation and nucleic acid detection ... PCR and viral antigen detection are more accurate in the first seven days.[27] In 2012 a PCR test was introduced that can run ...
The first sign of Hepatitis D was detected in 1978 when a strange and unrecognizable internuclear antigen was discovered during ... As North America contains several core nations, the growing economies in those nations are able to maintain and develop medical ... Incubation of Hepatitis D typically lasts for thirty five days. Most often Hepatitis D is a co-infection with Hepatitis B or a ... Normally Hepatitis B is transmitted through blood or any type of blood product. In South America Hepatitis D was found to be ...
Core vaccines for dogs include attenuated live CAdV-2, which produces immunity to CAdV-1 and CAdV-2. CAdV-1 was initially used ... Two types of canine adenoviruses are well known, type 1 and 2. Type 1 (CAdV-1) causes infectious canine hepatitis, a ... Adenovirus dodecahedron can qualify as a potent delivery platform for foreign antigens to human myeloid dendritic cells (MDC), ... CAdV-1 also affects foxes (Vulpes vulpes, Vulpes lagopus) and may cause except hepatitis also encephalitis. Canine adenovirus 2 ...
These include HIV, Hepatitis B, Hepatitis C, Treponema pallidum (syphilis) and, where relevant, other infections that pose a ... Antibodies to human Neutrophil Antigen's (HNA) and Human Leukocyte Antigens (HLA) have been associated with this type of ... Core body temperature can go down as low as 32 °C and can produce physiologic disturbances. Prevention should be done with ... Hepatitis B; Hepatitis C; or syphilis.[10] One of the main reasons for this is because testing kits are not always available.[ ...
Antigen determinants that possess type-specific reactivity are found on the envelope. Antigen determinants that possess type- ... The nucleocapsids (cores) are isometric. The nucleoids are concentric and rod-shaped, or shaped like a truncated cone.[5] ... Some groups have cross-reactive gag antigens (e.g., the ovine, caprine, and feline lentiviruses). Antibodies to gag antigens in ... Serological Relationships: Antigen determinants are type-specific and group-specific. ...
Hsieh TY, Matsumoto M, Chou HC, Schneider R, Hwang SB, Lee AS, Lai MM (1998). "Hepatitis C virus core protein interacts with ... Buckanovich RJ, Posner JB, Darnell RB (1993). "Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and ...
Branched PEGs have three to ten PEG chains emanating from a central core group. Star PEGs have 10 to 100 PEG chains emanating ... In blood banking, PEG is used as a potentiator to enhance detection of antigens and antibodies. When working with phenol in a ... PEGylated interferon alfa-2a or −2b are commonly used injectable treatments for hepatitis C infection. PEG is soluble in water ... from a central core group. Comb PEGs have multiple PEG chains normally grafted onto a polymer backbone. The numbers that are ...
References for Abcams Recombinant Hepatitis B Virus Core Antigen protein (ab119471). Please let us know if you have used this ...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
Mouse monoclonal antibody raised against recombinant hepatitis B virus core antigen Recombinant protein corresponding to ... hepatitis B virus core antigen core. (MAB5403) - Products - Abnova ... Hepatitis B virus core antigen monoclonal antibody, clone 10C6. Hepatitis B virus core antigen monoclonal antibody, clone 10C6 ...
Recombinant protein corresponding to hepatitis B core antigen. (MAB4774) - Products - Abnova ... Mouse monoclonal antibody raised against recombinant hepatitis B core antigen. ... HBcAg core antigen. Amino acids 135-140 core antigen. Reacts with synthetic HBc peptides. ... Hepatitis B virus core antigen monoclonal antibody, clone 13A9. Hepatitis B virus core antigen monoclonal antibody, clone 13A9 ...
The capsid (core antigen, HBcAg) is one of three major antigens present in patients infected with Hepatitis B Virus. The ... Antigenic determinants and functional domains in core antigen and e antigen from hepatitis B virus. J Virol. 1989;63:798-808. [ ... Diversity of core antigen epitopes of hepatitis B virus. Proc Natl Acad Sci USA. 2003;100:10884-9. [PubMed] ... Antigenic character of hepatitis B virus core antigen (capsids). In the HBV virion, a capsid containing the viral genome is ...
... for determination of IgM class antibodies to Hepatitis B Virus core Antigen in plasma and sera with the capture system. ... An Enzyme ImmunoAssay (ELISA) for determination of IgM class antibodies to Hepatitis B Virus core Antigen in plasma and sera ...
Monoclonal Antibody to Hepatitis B Core Antigen (HBcAg), (ayw) (a.a. 1-10) N-terminal End [10E11], validated in WB, IHC, IP, ... HBcAg core antigen. Produced against recombinant HBcAg core antigen (ayw). Reacts with synthetic HBc peptides. ... Monoclonal Antibody to Hepatitis B Core Antigen (HBcAg), (ayw) (a.a. 1-10) N-terminal End [10E11] is for research use only and ... Monoclonal Antibody to Hepatitis B Core Antigen (HBcAg), (ayw) (a.a. 1-10) N-terminal End [10E11]. ...
... identification of a core antigen‐antibody system that cross reacts with hepatitis b core antigen and antibody, Journal of ... Non‐A, non‐b hepatitis virus: identification of a core antigen‐antibody system that cross reacts with hepatitis b core antigen ... Non‐A, non‐b hepatitis virus: identification of a core antigen‐antibody system that cross reacts with hepatitis b core antigen ... "Non‐A, non‐b hepatitis virus: identification of a core antigen‐antibody system that cross reacts with hepatitis b core antigen ...
IHC Double Stain for Hepatitis B Surface Antigen (HBsAg) and Hepatitis B Core Antigen (HBcAg) ... Both images show hepatitis infected hepatocytes. HBsAg is demonstrated by red cytoplasmic staining and HBcAg is shown by brown ...
Hepatitis B Core Antigen (HBcAg) and Hepatitis B Surface Antigen (HBsAg) Double Stain in Liver. ...
Hepatitis B core antigen is an indicator of active viral replication. A patient infected with Hepatitis B testing positive… ... Recombinant Hepatitis B virus core antigen (HBcAg), amino acids 1-183.,br,,br, ... Recombinant Hepatitis B virus core antigen (HBcAg), amino acids 1-183.. Hepatitis B core antigen is an indicator of active ... A patient infected with Hepatitis B testing positive for the core antigen is more likely to transmit the virus to others. ...
The full-length HBc antigen was used, because the C-terminal arginine-rich tail may contribute to the immunogenicity of the ... is known as one of the most immunogenic antigens and carrier vehicles in different immunization strategies. Recent findings are ... antigen as the region is involved in cell surface heparan sulfate binding and internalization of the protein. Serum antibody ... The hepatitis B virus core (HBc) virus-like particle (VLP) ... The hepatitis B virus core (HBc) virus-like particle (VLP) is ...
Hepatitis core antigen (IPR002006). Short name: Hepatitis_core Overlapping homologous superfamilies *Viral capsid core domain ... This entry represent the core antigen of the viral capsid (HBcAg) from various Hepatitis B virus (HBV), which is a major human ... The capsid is composed of a single polypeptide, HBcAg, also known as the core antigen. The capsid has a 5-helical fold, where ... This viral capsid acts as a core antigen, the major immunodominant region lying at the tips of the alpha-helical hairpins that ...
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Buy our Recombinant Hepatitis C Virus Core Antigen protein (Rhodamine). Ab49019 is a full length protein produced in ... Recombinant Hepatitis C Virus Core Antigen protein (Rhodamine). See all Hepatitis C Virus Core Antigen proteins and peptides. ... In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously ... However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core ...
Active Recombinant Hepatitis B Virus Core Antigen protein is an Escherichia coli Full length protein, , 95% purity and ... Recombinant Hepatitis B Virus Core Antigen protein. See all Hepatitis B Virus Core Antigen proteins and peptides. ... Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral ... The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent ...
Browse our Hepatitis C Virus Core Antigen all backed by our Guarantee+. ... Hepatitis C Virus Core Antigen available through Novus Biologicals. ...
LBDHBG - Hepatitis B surface antigen. Variable Name: LBDHBG SAS Label: Hepatitis B surface antigen. English Text: Hepatitis B ... Hepatitis B: Core Antibody, Surface Antigen; Hepatitis D Antibody (HEPBD_G) Data File: HEPBD_G.xpt First Published: September ... The Hepatitis B surface antigen is tested only when the Hepatitis B core antibody test is positive. Participant results are ... LBXHBC - Hepatitis B core antibody (Anti-HBc). Variable Name: LBXHBC SAS Label: Hepatitis B core antibody (Anti-HBc). English ...
LBXHBC - Hepatitis B core antibody. Variable Name: LBXHBC. SAS Label: Hepatitis B core antibody. English Text: Hepatitis B core ... LBDHBG - Hepatitis B surface antigen. Variable Name: LBDHBG. SAS Label: Hepatitis B surface antigen. English Text: Hepatitis B ... Hepatitis B: Core Antibody, Surface Antigen; Hepatitis D Antibody (HEPBD_D) Data File: HEPBD_D.xpt First Published: February ... Hep B- The hepatitis B core antibody test is performed on all examinees 6 years old and older while the hepatitis B surface ...
Hepatitis C Core Antigen Testing for Diagnosis of Hepatitis C Virus Infection: A Systematic Review and Meta-analysis J. Morgan ... Hepatitis C Core Antigen Testing for Diagnosis of Hepatitis C Virus Infection: A Systematic Review and Meta-analysis. Ann ... Testing for hepatitis C virus core antigen (HCVcAg) is a potential alternative to NAT. ... Curing Hepatitis C Virus Infection: Best Practices From the U.S. Department of Veterans Affairs Annals of Internal Medicine; ...
Quantitation of hepatitis B virus (HBV) core antigen in serum in the presence of antibodies to HBV core antigen: comparison ... Hepatitis B virus core and core-related antigen quantitation in Chinese patients with chronic genotype B and C hepatitis B ... Several assays have been developed for the measurement of serum hepatitis B e antigen (HBeAg) or hepatitis B core antigen ( ... Hepatitis B Virus Core-Related Antigens as Markers for Monitoring Chronic Hepatitis B Infection. Danny Ka-Ho Wong, Yasuhito ...
Invitrogen Anti-Hepatitis B Virus Core Antigen Monoclonal (H6F5), Catalog # MA1-21697. Tested in Western Blot (WB) and ELISA ( ... The antigens in the outer surface are called as hepatitis B virus surface antigens. Core antigens are localized within the ... Cite Hepatitis B Virus Core Antigen Monoclonal Antibody (H6F5). The following antibody was used in this experiment: Hepatitis B ... The antigenic activity of the nucleocapsid core is designated as hepatitis B core antigen. ...
IgM antibody against hepatitis B core antigen (IgM anti-HBc), a marker of recent hepatitis B virus infection, was sought by ... IgM antibody against hepatitis B core antigen (IgM anti-HBc): diagnostic and prognostic significance in acute HBsAg positive ... IgM antibody against hepatitis B core antigen (IgM anti-HBc): diagnostic and prognostic significance in acute HBsAg positive ... IgM antibody against hepatitis B core antigen (IgM anti-HBc): diagnostic and prognostic significance in acute HBsAg positive ...
Hepatitis core antigen produced in Escherichia coli: subunit composition, conformational analysis, and in vitro capsid assembly ... production and biochemical and physiocochemical analysis are described of recombinant-produced hepatitis B virus core antigen ( ... Hepatitis B Core Antigens/biosynthesis. *Hepatitis B Core Antigens/chemistry*. *Hepatitis B e Antigens/biosynthesis ...
The E.coli derived recombinant protein contains the HCV core nucleocapsid immunodominant regions, amino acids 1-102. HCV is a ... HCV Core Genotype-1 protein was purified by proprietary chromatographic technique.. Purity. HCV Core Genotype-1 protein is >95 ... HCV Core Genotype-1 although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. ... Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and ...
IPR002006, Hepatitis_core. IPR036459, Viral_capsid_core_dom_sf_HBV. Pfami. View protein in Pfam. PF08290, Hep_core_N, 1 hit ... IPR013195, Hepatitis_B_virus_capsid_N. IPR002006, Hepatitis_core. IPR036459, Viral_capsid_core_dom_sf_HBV. ... sp,P89951,HBEAG_HBVGB External core antigen OS=Gibbon hepatitis B virus subtype ayw3q (isolate Hope) OX=489544 GN=C PE=3 SV=1 ... Isoform External core antigen (identifier: P89951-1) [UniParc]FASTAAdd to basketAdded to basket. ...
Activation of Hepatitis B Virus (HBV) in Hepatitis B Surface Antigen (HBsAg) - Negative But Hepatitis B Core Antibody (Anti-HBc ... Individuals with resolved hepatitis B, characterized as hepatitis B surface antigen (HBsAg)-negative and hepatitis B core ... Hepatitis. Hepatitis A. Hepatitis B. Liver Diseases. Digestive System Diseases. Hepatitis, Viral, Human. Virus Diseases. ... resulting in de novo hepatitis B. Although de novo hepatitis B could cause acute liver failure or chronic hepatitis, an ...
Patients with chronic hepatitis B (CHB) have highly variable outcomes with diverse clinical features and prognosis.1 Through ... Quantification of Antibody to Hepatitis B Core Antigen to Predict Outcomes of Patients With HBV Infection. *. ... Immune-mediated hepatitis can be particularly challenging if patients have underlying viral hepatitis or autoimmune hepatitis. ... Determinants of Liver Complications Among HIV/Hepatitis B Virus-Coinfected Patients. Background: Hepatitis B virus (HBV) ...
2020 May 29;: Authors: Mak LY, Ko KL, To WP, Wong DK, Seto WK, Fung J, Yuen MF Abstract Serum hepatitis B core-related antigen ... HBcrAg) was shown to predict the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients undergoing... ... Entecavir Reduced Serum Hepatitis B Core-Related Antigen in Chronic Hepatitis B Patients with Hepatocellular Carcinoma. Gut ... Entecavir Reduced Serum Hepatitis B Core-Related Antigen in Chronic Hepatitis B Patients with Hepatocellular Carcinoma.. *. ...
IPR002006 Hepatitis_core. IPR036459 Viral_capsid_core_dom_sf_HBV. Pfami. View protein in Pfam. PF08290 Hep_core_N, 1 hit. ... IPR013195 Hepatitis_B_virus_capsid_N. IPR002006 Hepatitis_core. IPR036459 Viral_capsid_core_dom_sf_HBV. ... sp,Q4R1S0,HBEAG_HBVA9 External core antigen OS=Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) OX=489459 GN=C PE=3 ... Isoform External core antigen (identifier: Q4R1S0-1) [UniParc]FASTAAdd to basketAdded to basket. ...
Anti-Hepatitis B Virus Core Antigen mAb (GTX41801) is tested in Hepatitis B virus samples. 100% Ab-Assurance. ... Hepatitis B Virus Core Antigen antibody [H3A4] for ELISA, WB. ... Hepatitis B Virus Core Antigen antibody [H3A4]. *Host / ... Hepatitis B Virus Core Antigen antibody [H3A4] See all Hepatitis B Virus Core Antigen products ... Specifications: Hepatitis B Virus Core Antigen antibody [H3A4]. Specificity. Hepatitis B virus core antigen. ...
Anti-Hepatitis B Virus Core Antigen mAb (GTX22045) is tested in Hepatitis B virus samples. 100% Ab-Assurance. ... Hepatitis B Virus Core Antigen antibody [H6F5] for ELISA, WB. ... Hepatitis B Virus Core Antigen antibody [H6F5]. *Host / ... Hepatitis B Virus Core Antigen antibody [H6F5] See all Hepatitis B Virus Core Antigen products ... The antigenic activity of the nucleocapsid core is designated as hepatitis B core antigen. Some reports show that core antigens ...
... viral load and prognosis in chronic hepatitis B patients. Download Prime PubMed App to iPhone, iPad, or Android ... Hepatitis B virus mutations associated with in situ expression of hepatitis B core antigen, ... Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in patients ... ViralFemaleHepatitis B Core AntigensHepatitis B virusHepatitis B, ChronicHumansImmunohistochemistryLiverLiver CirrhosisLiver ...
The accuracy and cost-effectiveness of hepatitis C core antigen assay in the monitoring of anti-viral therapy in patients with ... A good correlation existed between HCV viral load and HCV core antigen levels (r = 0.944; P < 0.0001). Baseline HCV RNA values ... The sustained virological response rate (SVR) was 66.34%. The All-HCV core antigen and hybrid monitoring assays resulted in the ... study compared the efficacy and cost benefit of an All-HCV core antigen assay protocol and a hybrid qtHCV RNA PCR and HCV core ...
Measurement of hepatitis B virus core-related antigen is valuable for identifying patients who are at low risk of lamivudine ... Measurement of hepatitis B virus core-related antigen as predicting factor for relapse after cessation of lamivudine therapy ... Sensitive enzyme immunoassay for hepatitis B virus core-related antigens and their correlation to virus load KIMURA T ... Clinical evaluation of a new enzyme immunoassay for hepatitis B virus core-related antigen ; a marker distinct from viral DNA ...
TiTLE HERE- - > Hepatitis C core antigen testing: a reliable, quick and potentially cost-effective alternative to Hepatitis C ... Hepatitis C core antigen testing: a reliable, quick and potentially cost-effective alternative to Hepatitis C polymerase chain ... 1. HCV core-antigen testing (Abbott Architect). 2. HCV RNA testing (Abbott Real-Time qRT-PCR). 3. HCV Antibody testing (Abbott ... "we believe that national guidelines should now begin to consider HCV core-antigen testing as an integral part of their HCV ...
The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when ... Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity ... Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity ... The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when ...
Buy Hepatitis C Virus Core Antigen Monoclonal Antibody from Invitrogen for Immunoprecipitation and ELISA applications. This ... 100 ug Hepatitis B Virus Core Antigen Antibody (Monoclonal, 13A9). *Hepatitis B Virus Core Antigen Antibody (Monoclonal, 13A9) ... Related Products for 100 ug Hepatitis C Virus Core Antigen Antibody (Monoclonal, 11B3):. 100 ug Hepatitis C Virus Core Antigen ... 100 ug Hepatitis B Virus Core Antigen Antibody (Monoclonal, 14E11). *Hepatitis B Virus Core Antigen Antibody (Monoclonal, 14E11 ...
Hepatitis C virus (HCV)-specific T cell responses have been suggested to play significant role in viral clearance. Dendritic ... Against Hepatitis C Virus-Derived Antigens NS3 or Core by Autologous Dendritic Cells Expressing Hepatitis C Virus Antigens: ... Against Hepatitis C Virus-Derived Antigens NS3 or Core by Autologous Dendritic Cells Expressing Hepatitis C Virus Antigens: ... Expression of hepatitis C virus-derived core or NS3 antigens in human dendritic cells leads to induction of pro-inflammatory ...
  • Hepatocyte cytoplasm is filled with HBsAg (surface antigen), forming dull homogeneous granular eosinophilic inclusions. (pixorize.com)
  • The full-length HBc antigen was used, because the C-terminal arginine-rich tail may contribute to the immunogenicity of the antigen as the region is involved in cell surface heparan sulfate binding and internalization of the protein. (semanticscholar.org)
  • The E.coli derived recombinant multimer protein contains the HCV core nucleocapsid immunodominant regions, amino acids 2-119. (creative-diagnostics.com)
  • Anti NANBc also became detectable in serial acute phase and convalescence sera from 5/5 NANB Ag‐positive posttransfusion hepatitis cases. (deepdyve.com)
  • Hantz, O. 1981-01-01 00:00:00 Using immunodiffusion, a major cross‐reactivity had been previously demonstrated between hepatitis B(HBe/3 Ag) and the antigen reported in the serum of non‐A, non‐B hepatitis patients, therefore redesignated NANBe Ag. (deepdyve.com)
  • Liver‐derived NANBe Ag identical to serum NANBe Ag exhibited the same physical properties as HBe/3 Ag and could be similarly released by disruption of the non‐A, non‐B virus cores. (deepdyve.com)
  • Comparison of serum humoral responses induced by oral immunization with the hepatitis B virus core antigen and the cholera toxin B subunit. (semanticscholar.org)
  • Further characterization of NANBe and NANBc antigens achieved by fractionation of a NANB virus‐infected liver showed NANBc Ag to be expressed on 22-25 nm HB core‐like particles containing DNA polymerase activity. (deepdyve.com)
  • Expression, purification and characterization of full-length RNA-free hepatitis B core particles. (semanticscholar.org)
  • These results indicate that hepatitis B and NANB virions not only share the same structure and DNA polymerase activity but are also antigenically related and belong to the same new class of DNA viruses. (deepdyve.com)
  • Hepatitis B core antigen (HBcore) can self-assemble into VLP (virus-like particles) when it is produced in plants and it has shown to be an attractive carrier for presentation of foreign epitopes for the development of subunit vaccines. (conicet.gov.ar)
  • In particular, patients with serum HBV DNA levels ≥ 3.3 log IU/mL (2000 IU/mL) at baseline have an increased likelihood of developing hepatitis B e antigen (HBeAg)‐negative hepatitis, cirrhosis, and HCC during long‐term follow‐up. (deepdyve.com)
  • In conclusion, precore mutations occurred in a large proportion of Chinese patients with chronic hepatitis B virus before HBeAg seroconversion. (hku.hk)
  • A modified PCR-RFLP assay and ELISA were adopted to determine A336C/A336T/T337C variations and serum HBeAg levels in chronic hepatitis B patients without any antiviral therapy, respectively, whereas G1896A variation and HBV genotype were detected using Taqman-PCR assay. (biomedcentral.com)
  • Chi-square test showed that C336/T336/C337 variants was more frequent in chronic hepatitis B patients with A1896 variants than those with the wild type G1896 (χ2 = 4.7, P = 0.03), and moreover, patients with C336/T336/C337 variants had a significantly lower HBeAg-positive percentage than those with the wild type A336/T337. (biomedcentral.com)
  • A336C/A336T/T337C were naturally occurring polymorphisms in HBV core gene, and moreover, the presence of C336/T336/C337 variants was first demonstrated to be an independent factor associating with spontaneous HBeAg loss in chronic hepatitis B patients. (biomedcentral.com)
  • Spontaneous hepatitis B e antigen (HBeAg) loss during the course of chronic HBV infection is usually accompanied by the disappearance of the biochemical markers of hepatitis and a drastic decrease in viral replication. (biomedcentral.com)
  • The core promoter mutants of hepatitis B virus (HBV) emerge as the dominant viral population at the late HBeAg and the anti-HBe stages of HBV infection, with the A1762T/G1764A substitutions as the hotspot mutations. (core.ac.uk)
  • The double core promoter mutations were found by many investigators to moderately enhance viral genome replication and reduce hepatitis B e antigen (HBeAg) expression. (core.ac.uk)
  • If you are HBV DNA positive but this HBeAg test result is negative, then you still have the hepatitis B virus in your bloodstream. (va.gov)
  • Relation of hepatitis B core antigen expression with histological activity, serum HBeAg, and HBV DNA levels. (bvsalud.org)
  • Using well-characterized cohort of treatment-naïve patients with chronic HBV infection in The Gambia, we evaluated the accuracy of serum HBcrAg to diagnose HBV DNA levels, and to indicate treatment eligibility determined by the American Association for the Study of Liver Diseases, based on the reference tests (HBV DNA, HBV e antigen (HBeAg), alanine transaminase (ALT), liver histopathology and/or FibroScan). (pasteur.fr)
  • 19). All 16 CH patients, who were positive for hepatitis B e antigen (HBeAg) and 5 ASC cases who were negative for both HBeAg and its antibody (anti-HBe), had high anti-HBc titers. (elsevier.com)
  • Another protein in the core known as HBeAg is released into the bloodstream during active viral replication. (healthhype.com)
  • This viral capsid acts as a core antigen, the major immunodominant region lying at the tips of the alpha-helical hairpins that form spikes on the capsid surface. (ebi.ac.uk)
  • The antigens in the outer surface are called as hepatitis B virus surface antigens. (thermofisher.com)
  • Core antigens are localized within the nuclei whereas the surface antigens are present in the cytoplasm of the infected cells. (thermofisher.com)
  • Antibodies to surface antigens appear in circulation at an early stage of infection whereas the antibodies to the core antigens are detected after several weeks. (thermofisher.com)
  • Trans Am Clin Climatol Assoc. 2019;130:104-118 Authors: Alter HJ Abstract The modern age of viral hepatitis began in the early 1960s with the serendipitous discovery of the Australia antigen, a protein that was later shown to represent the envelope of the hepatitis B virus leading to its designation as the hepatitis B surface antigen. (medworm.com)
  • Both inserted proteins are correctly folded and the nanobody fused to the surface of the tandem core particle (which we name tandibody) retains the ability to bind to its cognate antigen. (jic.ac.uk)
  • Thus, the "footprint" of a bound Fab on the antigen surface may be delineated by comparison with an unlabeled control structure. (pubmedcentralcanada.ca)
  • Cellular antigens are proteins or oligosaccharides that mark and identify the cell surface as self or nonself . (tabers.com)
  • Cell surface antigens can stimulate the production of antibodies by B lymphocytes and cytotoxic responses by white blood cells, e.g., granulocytes, monocytes, and lymphocytes. (tabers.com)
  • Australian antigen A term formerly used for hepatitis B surface antigen. (tabers.com)
  • DNA-mediated immunization in mice induces a potent MHC class I-restricted cytotoxic T lymphocyte response to hepatitis B surface antigen. (cdc.gov)
  • We performed this study to find the prevalence of hepatitis B surface antigen, anti-hepatitis B core antibody, and associated factors in the general population of three provinces of Iran. (ac.ir)
  • Results: The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran was 2.6 and 16.4, respectively. (ac.ir)
  • Predictors of hepatitis B surface antigen or anti-hepatitis B core antibody in multivariate analysis included older age, not having high-school diploma, living in a rural area, and liver disease in a family member. (ac.ir)
  • The full-length HBc antigen was used, because the C-terminal arginine-rich tail may contribute to the immunogenicity of the antigen as the region is involved in cell surface heparan sulfate binding and internalization of the protein. (semanticscholar.org)
  • Reactive Hepatitis B Surface Antigen will reflex to the Hepatitis B Surface Antigen Confirmatory neutralization test for an additional charge. (legacyhealth.org)
  • The viral envelope is made up from host cell lipid, with viral surface antigens (DHBsAg). (wikipedia.org)
  • The genome has three overlapping open reading frames or ORFs: C-ORF - encoding the core antigen and pre-core protein which are processed and secreted as DHBcAg S-ORF - codes for the surface antigen DHBsAg P-ORF - encoding the viral polymerase. (wikipedia.org)
  • The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. (abcam.com)
  • Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. (abcam.com)
  • The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. (abcam.com)
  • The icosahedral core particle contains 180 or 240 copies of the core protein. (abcam.com)
  • The E.coli derived recombinant protein contains the HCV core nucleocapsid immunodominant regions, amino acids 1-102. (prospecbio.com)
  • HCV Core Genotype-1 protein was purified by proprietary chromatographic technique. (prospecbio.com)
  • HCV Core Genotype-1 protein is >95% pure as determined by 10% PAGE (coomassie staining). (prospecbio.com)
  • The MA1-7613 immunogen is a purified recombinant HCV core protein. (thermofisher.com)
  • Recombinant protein corresponding to hepatitis B core antigen. (abnova.com)
  • The majority of epitopes on native (i.e., folded) protein antigens are thought to be conformational ( 4 ). (asm.org)
  • The basic idea is as follows: provided that the antigen structure is known to high resolution, a cryo-EM structure of the antigen-Fab complex at moderate resolution, probed by molecular modeling with a generic Fab structure from the protein database, contains sufficient information to allow identification of the peptides that make up the epitope. (asm.org)
  • Small volumes of HEPATITIS B CORE ANTIGEN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. (mybiosource.com)
  • The purpose of this study was ‎to design and prepare a specific mRNA, without 5chr('39') cap and poly (A) tail transcribed in vitro capable of coding core protein and also to determine its functionality. (ac.ir)
  • DCs were transfected by in vitro- transcribed messenger RNA (IVT-mRNA) and the expressions of green fluorescent protein ( GFP) , and Core genes were determined by microscopic examination and Western blotting assay. (ac.ir)
  • Snrnpd1 is a member of the SnRNP core protein family. (biocompare.com)
  • The protein marker in the Rh group of antigens that stimulates the greatest immune response. (tabers.com)
  • The hepatitis C core antigen is a viral protein. (treatmentactiongroup.org)
  • Hepatitis B virus core antigen protein gene (C gene) was expressed in Saccharomyces cerevisiae and the products (rHBcAg particles) were purified from crude lysate of the yeast by three steps: Sephrose CL-4B chromatography, sucrose step-gradient ultracentrifugation, and CsCl-isopycnic ultracentrifugation. (virosin.org)
  • In this study HCV core-antigen testing on the Architect platform displayed high sensitivity (100%) and specificity (97.96%) in diagnosing acute HCV in HIV-infected individuals who experience elevated transaminases. (natap.org)
  • Background Phage display is an alternative method for constructing and selecting antibodies with desired specificity towards an antigen. (upm.edu.my)
  • I am looking for HBV core antigen of different genotype. (abcam.com)
  • All three of the core antigen proteins you asked about are from the HBV320 strain, genotype D. The article at this URL, https://www.ncbi.nlm.nih.gov/pubmed/?term=8336122, identifies the genotype of HBV320 and many other strains in Figures 1 and 2. (abcam.com)
  • Note: This[DM((1] file is being updated to report Hepatitis C genotype in more detail. (cdc.gov)
  • Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. (prospecbio.com)
  • HCV Core Genotype-1 although stable at 4°C for 1 week, should be stored below -18°C. (prospecbio.com)
  • The accuracy and cost-effectiveness of hepatitis C core antigen assay in the monitoring of anti-viral therapy in patients with chronic hepatitis C genotype 4. (sigmaaldrich.com)
  • Four hundred and ten patients with chronic hepatitis C genotype 4 met inclusion criteria and were enrolled in the study. (sigmaaldrich.com)
  • However, about 50% genotype 1 chronic hepatitis C patients, who are the most common worldwide, do not achieve SVR. (biomedcentral.com)
  • In conclusion, hepatitis C virus core antigen is comparable to hepatitis C virus RNA in predicting sustained virologic response of chronic genotype 1 hepatitis C virus infected patients , and can be used to guide anti- hepatitis C virus treatment , especially in resource -limited areas. (bvsalud.org)
  • This is more likely in young people (especially women), people who do not have HIV, and people with the IL28B CC genotype (refer to TAG's Hepatitis C and the IL28B Gene fact sheet). (treatmentactiongroup.org)
  • Reference sequences of preCore/Core from HBV genotypes A-H are highlighted with coloured backgrounds, and preCore/Core reference sequences (AB014381, AY123041, X04615) of genotype C are underlined and highlighted by red text (scattered among the patient preCore/Core sequences). (cdc.gov)
  • Simple One-step Purification of Hepatitis B Core Antigen in Escherichia coli', Journal of Biomedicine and Health , 1(3), pp. 1-5. (jbiom.com)
  • The antigenic activity of the nucleocapsid core is designated as hepatitis B core antigen. (thermofisher.com)
  • The icosahedral nucleocapsid within, is composed of the virus core antigen (DHBcAg) and surrounds the DNA genome and viral polymerase. (wikipedia.org)
  • A sensitive chemiluminescence enzyme immunoassay has been developed for hepatitis B virus (HBV) core-related antigen (HBcrAg) detection. (asm.org)
  • We aimed to investigate the usefulness of HBcrAg measurement for monitoring chronic hepatitis B disease. (asm.org)
  • A higher HBcrAg concentration was associated with a greater proportion of hepatitis B core antigen immunostaining. (asm.org)
  • A greater reduction in posttreatment HBcrAg concentration was associated with histological improvement and a decrease in hepatitis B core antigen immunostaining. (asm.org)
  • Co-infection with hepatitis D virus (HDV) in persons with acute or chronic hepatitis B virus (HBV) infection can lead to fulminant hepatitis. (cdc.gov)
  • NHANES testing for markers of infection with hepatitis viruses will be used to determine secular trends in infection rates across most age and racial/ethnic groups, and will provide a national picture of the epidemiologic determinants of these infections. (cdc.gov)
  • Hepatitis B virus (HBV) belongs to the Hepadnaviridae family and infection with HBV is usually more serious than infection with hepatitis A virus. (thermofisher.com)
  • In 320 patients (85%) a positive IgM anti-HBc test result confirmed that hepatitis was due to primary infection with hepatitis B virus. (bmj.com)
  • Serological Diagnosis of Hepatitis A virus InfectionHepatitis A cannot be distinguished from other types of viral hepatitis on the basis of clinical or epidemiologic features alone. (microbeonline.com)
  • Cancer antigens are used in clinical medicine to screen body fluids for tumors or to follow the response of tumors to treatment. (tabers.com)
  • Impact of previous hepatitis B infection on the clinical outcomes from chronic hepatitis C? (nih.gov)
  • The Scottish Hepatitis C Clinical Database containing data for all patients attending HCV clinics in participating health boards was linked to the HBV diagnostic registry and mortality data from Information Services Division, Scotland. (nih.gov)
  • Urgent liver biopsy, transjugular if appropriate, may help to confirm the clinical suspicion of acute autoimmune hepatitis. (medscape.com)
  • Chronic hepatitis B is seen where the virus does not clear and the infection persists past 6 months.The clinical features of chronic HBV infection depends on the degree of liver damage. (healthhype.com)
  • The International Immunodiagnostics HDV Ab assay is a competitive enzyme immunoassay (ELISA) for the determination of antibodies to Hepatitis D Virus or HDV in human plasma and sera with a 'two step" methodology. (cdc.gov)
  • This longitudinal, non-inferiority study compared the efficacy and cost benefit of an All-HCV core antigen assay protocol and a hybrid qtHCV RNA PCR and HCV core Ag assay protocol to the standard All-qtHCV-PCR protocol in chronic HCV G4 patients treated with pegylated interferon (PEG IFN) and ribavirin. (sigmaaldrich.com)
  • The HCV antigen assay is a suitable tool for the detection of chronic active HCV infections, for the early diagnosis of acute infections and for testing of HCV in patient with immunodeficiency. (springer.com)
  • The HCV antigen assay valuable completion of serological testing for HCV. (springer.com)
  • In addition, HCV core antigen is a recently developed marker of hepatitis C infection. (abcam.com)
  • HCV core-antigen can be used as a marker of viraemia as there is good non-linear correlation with HCV-RNA (r=0.87 vs. Abbot Real-Time qRT-PCR) with the lower limit of detection corresponding to HCV viral load of 700-1100 IU/ml [10]. (natap.org)
  • We aimed at determining any association of previous HBV infection with liver outcomes using antibodies to the hepatitis B core antigen (HBcAb) positivity as a marker of exposure. (nih.gov)
  • In this study we compare the utility of HCV core-antigen compared to qRT-PCR in the diagnosis on acute HCV in an HIV-positive cohort. (natap.org)
  • During the lab diagnosis of Hepatitis B, we perform serological tests. (microbeonline.com)
  • The aim of the evaluation was to investigate the relevance of the HCV-core antigen testing for the diagnosis and monitoring of HCV infections in the daily routine. (springer.com)
  • A positive antibody test result means that a person has been infected with hepatitis C. It does not mean that the person still has hepatitis C. A different test, to look for the actual hepatitis C virus, is needed to make a diagnosis. (treatmentactiongroup.org)
  • The diagnosis can be difficult but to be sure you should have the DNA and antigen tests. (healingwell.com)
  • Reactions to antigens by T and B cells are part of the specific immune response. (tabers.com)
  • They are part of the immune system's response to viruses, bacteria, and other harmful substances (called antigens ). (treatmentactiongroup.org)
  • Antibodies attach themselves to antigens or infected cells and tag them so that other immune cells can find and disable them. (treatmentactiongroup.org)
  • If the same antigen enters a person's body again, even years later, the immune system will remember it-and send antibodies to destroy it. (treatmentactiongroup.org)
  • Sometimes, the immune system gets rid of hepatitis C virus by itself (this is called spontaneous viral clearance ). (treatmentactiongroup.org)
  • A negative antibody test result usually means that the person has not been infected with hepatitis C (unless they were infected very recently or have a weakened immune system). (treatmentactiongroup.org)
  • A positive test result means you have been infected with hepatitis A in the past or were vaccinated against hepatitis A in the past but are now immune (protected) against being infected with hepatitis A virus in the future. (va.gov)
  • The body's immune system inappropriately produces antibodies directed against liver tissue, causing hepatitis. (labtestsonline.org)
  • Acute hepatitis with subsequent recovery and total clearance of the virus in a person with a healthy immune system. (healthhype.com)
  • Viral proteins (antigens) trigger the immune system to produce corresponding antibodies. (healthhype.com)
  • When these antibodies bind with the antigens it helps to direct the activity of immune cells. (healthhype.com)
  • The following antibody was used in this experiment: Hepatitis B Virus Core Antigen Monoclonal Antibody (H6F5) from Thermo Fisher Scientific, catalog # MA1-21697, RRID AB_559401. (thermofisher.com)
  • 100 ug Hepatitis C Virus Core Antigen Antibody (Monoclonal, 11B3) from Thermo Fisher Scientific, Inc. (thermofisher.com)
  • The following antibody was used in this experiment: Hepatitis C Virus Core Antigen Monoclonal Antibody (11B3) from Thermo Fisher Scientific, catalog # MA1-7613, RRID AB_1075580. (thermofisher.com)
  • Mouse monoclonal antibody raised against recombinant hepatitis B core antigen. (abnova.com)
  • Conformational epitopes may be identified from crystal structures of the antigen complexed with Fab fragments of a monoclonal antibody, and such identifications have been achieved in a few cases (e.g., see references 24 and 32 ). (asm.org)
  • We demonstrate proof of principle by using this approach to dissect the binding of monoclonal antibody 3120, which is specific for a hitherto unidentified conformational epitope on hepatitis B virus (HBV) capsids ( 35 ). (asm.org)
  • Hepatitis viruses constitute a major public health problem because of the morbidity and mortality associated with the acute and chronic consequences of these infections. (cdc.gov)
  • In addition, NHANES provides the means to better define the epidemiology of other hepatitis viruses. (cdc.gov)
  • These results indicate that hepatitis B and NANB virions not only share the same structure and DNA polymerase activity but are also antigenically related and belong to the same new class of DNA viruses. (deepdyve.com)
  • Serology reagents intended to detect core antigens to hepatitis B viruses, DNA viruses of the genus Hepadnavirus, family Hepadnaviridae. (medicalproductguide.com)
  • 4 Sharing of contaminated injecting equipment, tattooing and other forms of blood-to-blood contact have been implicated in the transmission of HIV and hepatitis viruses among prison inmates, 5 and incarceration is associated with prevalent and incident HIV infection, hepatitis B and hepatitis C, particularly among IDUs. (mja.com.au)
  • Most often, hepatitis is caused by infection with certain viruses . (labtestsonline.org)
  • In the U.S., most common causes are hepatitis A, B and C viruses. (labtestsonline.org)
  • The five types of hepatitis viruses are common infectious causes of liver inflammation, and some like hepatitis A (HAV), B (HBV) and C (HCV) are more frequently seen infectious agents. (healthhype.com)
  • Compared with HCV antibody screening alone this test considerably shortens the diagnostic window, as the delay to antibody seroconversion previously reported by others after PCR positivity is confirmed here after antigen positivity [7]. (natap.org)
  • Two-step immunohistochemical staining showed the expression of viral antigens in situ. (unboundmedicine.com)
  • Intrahepatic expression patterns of viral antigens detected by immunohistochemistry may have prognostic implications in disease process. (bvsalud.org)
  • It is suggested that anti-HBc is associated with the liver damage that occurs before adolescence in chronic hepatitis B virus infection. (elsevier.com)
  • Of those who were anti-HCV positive, 33.7% (140/415) were unaware of their infection status, and 74.3% (185/249) of those who tested positive for anti-HBc reported that they had never had hepatitis B. (mja.com.au)
  • Individuals with age equal or greater than 60 years were also more likely to be anti-HBc positive which could only reflect that older people have a longer history of exposure to hepatitis B infection. (scielo.br)
  • A much higher replication capacity was reported for a naturally occurring core promoter mutant implicated in the outbreak of fulminant hepatitis, which was caused by the neighboring C1766T/T1768A mutations instead. (core.ac.uk)
  • Liver transplantation also may be used to rescue patients who present with fulminant hepatic failure secondary to autoimmune hepatitis. (medscape.com)
  • Fulminant hepatitis with destruction of large parts of the liver is life-threatening. (healthhype.com)
  • Conformational epitopes, on the other hand, are presented only when the antigen assumes its native conformation and are not recognized on peptides or denatured proteins. (asm.org)
  • New immunization strategies have been developed to eliminate the spread of HBV and hepatitis A virus (HAV) in the United States. (cdc.gov)
  • Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries. (thermofisher.com)
  • This report is the first of a two-part statement from the Advisory Committee on Immunization Practices (ACIP) that updates the strategy to eliminate hepatitis B virus (HBV) transmission in the United States. (cdc.gov)
  • Muraskin W . The war against hepatitis B: a history of the international task force on hepatitis B immunization. (cdc.gov)
  • The hepatitis B virus core (HBc) virus-like particle (VLP) is known as one of the most immunogenic antigens and carrier vehicles in different immunization strategies. (semanticscholar.org)
  • In this retrospective study, we investigated the prevalence and significance of mutations in part of the hepatitis B virus (HBV) x gene, and tried to clarify their relationship with clinicopathological or histopathological characteristics and prognosis in patients with chronic hepatitis B (CHB). (unboundmedicine.com)
  • NCBI/Uniprot data below describe general gene information for HEPATITIS B CORE ANTIGEN . (mybiosource.com)
  • Candidate mRNA was prepared by in vitro transcription of the designed construct consisting of ‎‎5ʹ and 3ʹ untranslated regions of heat shock proteins 70 (hsp70) mRNA, T7 promoter, internal ribosome entry site (IRES) sequences of eIF4G related to human dendritic cells (DCs), and the ‎Core gene of HCV. (ac.ir)
  • Our findings indicated the effectiveness of a designed IVT-mRNA harboring the Core gene of HCV in transfecting and expressing the antigens in DCs. (ac.ir)
  • Certain gene mutations that are passed from one generation to the next can result in a disease that damages the liver, causing hepatitis. (labtestsonline.org)
  • The consensus statement was prepared by an expert panel representing the Gastroenterological Society of Australia (Australian Liver Association), the Australasian Society for Infectious Diseases, the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine, the Australasian Hepatology Association, Hepatitis Australia and the Royal Australian College of General Practitioners. (mja.com.au)