AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceNamed GroupsHealth Care
HepatectomyLiver RegenerationLiverLiver NeoplasmsCarcinoma, HepatocellularPortal Vein2-AcetylaminofluoreneHepatocytesLithiasisDiethylnitrosamineLiver TransplantationLiving DonorsBile Ducts, IntrahepaticRats, Inbred F344Bile Duct NeoplasmsHepatic VeinsTime FactorsLiver DiseasesLiver Function TestsBlood Loss, SurgicalLiver Neoplasms, ExperimentalCholangiocarcinomaOrgan SizeHemostasis, SurgicalHepatic ArteryHepatic Duct, CommonTreatment OutcomeHepatocyte Growth FactorCalculiLiver CirculationPreoperative CarePostoperative ComplicationsBile Ductsgamma-GlutamyltransferaseLiver FailureTissue and Organ HarvestingBilirubinRats, Inbred StrainsPyrrolizidine AlkaloidsProliferating Cell Nuclear AntigenRats, WistarHyptisRetrospective StudiesSubphrenic AbscessAlanine TransaminaseEmbolization, TherapeuticNeoplasm Recurrence, LocalAspartate AminotransferasesMitotic IndexSurvival RateDNA
Hepatectomy
Excision of all or part of the liver. (Dorland, 28th ed)
Liver Regeneration
Repair or renewal of hepatic tissue.
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Liver Neoplasms
Tumors or cancer of the LIVER.
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Portal Vein
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
2-Acetylaminofluorene
A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Hepatocytes
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
Lithiasis
A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract.
Diethylnitrosamine
A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
Liver Transplantation
The transference of a part of or an entire liver from one human or animal to another.
Living Donors
Non-cadaveric providers of organs for transplant to related or non-related recipients.
Bile Ducts, Intrahepatic
Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
Rats, Inbred F344
Bile Duct Neoplasms
Tumors or cancer of the BILE DUCTS.
Hepatic Veins
Veins which drain the liver.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Liver Diseases
Pathological processes of the LIVER.
Liver Function Tests
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
Blood Loss, Surgical
Loss of blood during a surgical procedure.
Liver Neoplasms, Experimental
Experimentally induced tumors of the LIVER.
Cholangiocarcinoma
A malignant tumor arising from the epithelium of the BILE DUCTS.
Organ Size
The measurement of an organ in volume, mass, or heaviness.
Hemostasis, Surgical
Control of bleeding during or after surgery.
Hepatic Artery
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
Hepatic Duct, Common
Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Hepatocyte Growth Factor
Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.
Calculi
An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones.
Liver Circulation
The circulation of BLOOD through the LIVER.
Preoperative Care
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Bile Ducts
The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.
gamma-Glutamyltransferase
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
Liver Failure
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Tissue and Organ Harvesting
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Bilirubin
A bile pigment that is a degradation product of HEME.
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Pyrrolizidine Alkaloids
A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Hyptis
A plant genus of the family LAMIACEAE that contains 5-methoxydehydropodophyllotoxin (a PODOPHYLLOTOXIN) and other LIGNANS.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Subphrenic Abscess
Accumulation of purulent EXUDATES beneath the DIAPHRAGM, also known as upper abdominal abscess. It is usually associated with PERITONITIS or postoperative infections.
Alanine Transaminase
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
Embolization, Therapeutic
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
Neoplasm Recurrence, Local
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Aspartate Aminotransferases
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
Mitotic Index
An expression of the number of mitoses found in a stated number of cells.
Survival Rate
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Risk of major liver resection in patients with underlying chronic liver disease: a reappraisal. (1/2543)

OBJECTIVE: To explore the relation of patient age, status of liver parenchyma, presence of markers of active hepatitis, and blood loss to subsequent death and complications in patients undergoing a similar major hepatectomy for the same disease using a standardized technique. SUMMARY BACKGROUND DATA: Major liver resection carries a high risk of postoperative liver failure in patients with chronic liver disease. However, this underlying liver disease may comprise a wide range of pathologic changes that have, in the past, not been well defined. METHODS: The nontumorous liver of 55 patients undergoing a right hepatectomy for hepatocellular carcinoma was classified according to a semiquantitative grading of fibrosis. The authors analyzed the influence of this pathologic feature and of other preoperative variables on the risk of postoperative death and complications. RESULTS: Serum bilirubin and prothrombin time increased on postoperative day 1, and their speed of recovery was influenced by the severity of fibrosis. Incidence of death from liver failure was 32% in patients with grade 4 fibrosis (cirrhosis) and 0% in patients with grade 0 to 3 fibrosis. The preoperative serum aspartate transaminase (ASAT) level ranged from 68 to 207 IU/l in patients with cirrhosis who died, compared with 20 to 62 in patients with cirrhosis who survived. CONCLUSION: A major liver resection such as a right hepatectomy may be safely performed in patients with underlying liver disease, provided no additional risk factors are present. Patients with a preoperative increase in ASAT should undergo a liver biopsy to rule out the presence of grade 4 fibrosis, which should contraindicate this resection.  (+info)

Intrahepatic recurrence after curative resection of hepatocellular carcinoma: long-term results of treatment and prognostic factors. (2/2543)

OBJECTIVE: This study aimed to evaluate the long-term results of treatment and prognostic factors in patients with intrahepatic recurrence after curative resection of hepatocellular carcinoma (HCC). SUMMARY BACKGROUND DATA: Recent studies have demonstrated the usefulness of re-resection, transarterial oily chemoembolization (TOCE), or percutaneous ethanol injection therapy (PEIT) in selected patients with intrahepatic recurrent HCC. The overall results of a treatment strategy combining these modalities have not been fully evaluated, and the prognostic factors determining survival in these patients remain to be clarified. METHODS: Two hundred and forty-four patients who underwent curative resection for HCC were followed for intrahepatic recurrence, which was treated aggressively with a strategy including different modalities. Survival results after recurrence and from initial hepatectomy were analyzed, and prognostic factors were determined by univariate and multivariate analysis using 27 clinicopathologic variables. RESULTS: One hundred and five patients (43%) with intrahepatic recurrence were treated with re-resection (11), TOCE (71), PEIT (6), systemic chemotherapy (8) or conservatively (9). The overall 1-year, 3-year, and 5-year survival rates from the time of recurrence were 65.5%, 34.9%, and 19.7%, respectively, and from the time of initial hepatectomy were 78.4%, 47.2%, and 30.9%, respectively. The re-resection group had the best survival, followed by the TOCE group. Multivariate analysis revealed Child's B or C grading, serum albumin < or = 40 g/l, multiple recurrent tumors, recurrence < or = 1 year after hepatectomy, and concurrent extrahepatic recurrence to be independent adverse prognostic factors. CONCLUSIONS: Aggressive treatment with a multimodality strategy could result in prolonged survival in patients with intrahepatic recurrence after curative resection for HCC. Prognosis was determined by the liver function status, interval to recurrence, number of recurrent tumors, any concurrent extrahepatic recurrence, and type of treatment.  (+info)

Subcellullar localization, developmental expression and characterization of a liver triacylglycerol hydrolase. (3/2543)

The mechanism and enzymic activities responsible for the lipolysis of stored cytosolic triacylglycerol in liver and its re-esterification remain obscure. A candidate enzyme for lipolysis, a microsomal triacylglycerol hydrolase (TGH), was recently purified to homogeneity from pig liver and its kinetic properties were determined [Lehner and Verger (1997) Biochemistry 36, 1861-1868]. We have characterized the enzyme with regard to its species distribution, subcellular localization, developmental expression and reaction with lipase inhibitors. The hydrolase co-sediments with endoplasmic reticulum elements and is associated with isolated liver fat droplets. Immunocytochemical studies localize TGH exclusively to liver cells surrounding capillaries. Both TGH mRNA and protein are expressed in rats during weaning. The enzyme covalently binds tetrahydrolipstatin, an inhibitor of lipases and of triacylglycerol hydrolysis. The enzyme is absent from liver-derived cell lines (HepG2 and McArdle RH7777) known to be impaired in very-low-density lipoprotein (VLDL) assembly and secretion. The localization and developmental expression of TGH are consistent with a proposed role in triacylglycerol hydrolysis and with the proposal that some of the resynthesized triacylglycerol is utilized for VLDL secretion.  (+info)

Split liver transplantation. (4/2543)

OBJECTIVE: This study reviews the indications, technical aspects, and experience with ex vivo and in situ split liver transplantation. BACKGROUND: The shortage of cadaveric donor livers is the most significant factor inhibiting further application of liver transplantation for patients with end-stage liver disease. Pediatric recipients, although they represent only 15% to 20% of the liver transplant registrants, suffer the greatest from the scarcity of size-matched cadaveric organs. Split liver transplantation provides an ideal means to expand the donor pool for both children and adults. METHODS: This review describes the evolution of split liver transplantation from reduced liver transplantation and living-related liver transplantation. The two types of split liver transplantation, ex vivo and in situ, are compared and contrasted, including the technique, selection of patients for each procedure, and the most current results. RESULTS: Ex vivo splitting of the liver is performed on the bench after removal from the cadaver. It is usually divided into two grafts: segments 2 and 3 for children, and segments 4 to 8 for adults. Since 1990, 349 ex vivo grafts have been reported. Until recently, graft and patient survival rates have been lower and postoperative complication rates higher in ex vivo split grafts than in whole organ cadaveric transplantation. Further, the use of ex vivo split grafts has been relegated to the elective adult patient because of the high incidence of graft dysfunction (right graft) when placed in an emergent patient. Reasons for the poor function of ex vivo splits except in elective patients have focused on graft damage due to prolonged cold ischemia times and rewarming during the long benching procedure. In situ liver splitting is accomplished in a manner identical to the living donor procurement. This technique for liver splitting results in the same graft types as in the ex vivo technique. However, graft and patient survival rates reported for in situ split livers have exceeded 85% and 90%, respectively, with a lower incidence of postoperative complications, including biliary and reoperation for bleeding. These improved results have also been observed in the urgent patient. CONCLUSION: Splitting of the cadaveric liver expands the donor pool of organs and may eliminate the need for living-related donation for children. Recent experience with the ex vivo technique, if applied to elective patients, results in patient and graft survival rates comparable to whole-organ transplantation, although postoperative complication rates are higher. In situ splitting provides two grafts of optimal quality that can be applied to the entire spectrum of transplant recipients: it is the method of choice for expanding the cadaver liver donor pool.  (+info)

Hepatectomy for hepatocellular carcinoma: toward zero hospital deaths. (5/2543)

OBJECTIVE: The authors report on the surgical techniques and protocol for perioperative care that have yielded a zero hospital mortality rate in 110 consecutive patients undergoing hepatectomy for hepatocellular carcinoma (HCC). The hepatectomy results are analyzed with the aim of further reducing the postoperative morbidity rate. SUMMARY BACKGROUND DATA: In recent years, hepatectomy has been performed with a mortality rate of <10% in patients with HCC, but a zero hospital mortality rate in a large patient series has never been reported. At Queen Mary Hospital, Hong Kong, the surgical techniques and perioperative management in hepatectomy for HCC have evolved yearly into a final standardized protocol that reduced the hospital mortality rate from 28% in 1989 to 0% in 1996 and 1997. METHODS: Surgical techniques were designed to reduce intraoperative blood loss, blood transfusion, and ischemic injury to the liver remnant in hepatectomy. Postoperative care was focused on preservation and promotion of liver function by providing adequate tissue oxygenation and immediate postoperative nutritional support that consisted of branched-chain amino acid-enriched solution, low-dose dextrose, medium-chain triglycerides, and phosphate. The pre-, intra-, and postoperative data were collected prospectively and analyzed each year to assess the influence of the evolving surgical techniques and perioperative care on outcome. RESULTS: Of 330 patients undergoing hepatectomy for HCC, underlying cirrhosis and chronic hepatitis were present in 161 (49%) and 108 (33%) patients, respectively. There were no significant changes in the patient characteristics throughout the 9-year period, but there were significant reductions in intraoperative blood loss and blood transfusion requirements. From 1994 to 1997, the median blood transfusion requirement was 0 ml, and 64% of the patients did not require a blood transfusion. The postoperative morbidity rate remained the same throughout the study period. Complications in the patients operated on during 1996 and 1997 were primarily wound infections; the potentially fatal complications seen in the early years, such as subphrenic sepsis, biliary leakage, and hepatic coma, were absent. By univariate analysis, the volume of blood loss, volume of blood transfusions, and operation time were correlated positively with postoperative morbidity rates in 1996 and 1997. Stepwise logistic regression analysis revealed that the operation time was the only parameter that correlated significantly with the postoperative morbidity rate. CONCLUSION: With appropriate surgical techniques and perioperative management to preserve function of the liver remnant, hepatectomy for HCC can be performed without hospital deaths. To improve surgical outcome further, strategies to reduce the operation time are being investigated.  (+info)

Continuous versus intermittent portal triad clamping for liver resection: a controlled study. (6/2543)

OBJECTIVE: The authors compared the intra- and postoperative course of patients undergoing liver resections under continuous pedicular clamping (CPC) or intermittent pedicular clamping (IPC). SUMMARY BACKGROUND DATA: Reduced blood loss during liver resection is achieved by pedicular clamping. There is controversy about the benefits of IPC over CPC in humans in terms of hepatocellular injury and blood loss control in normal and abnormal liver parenchyma. METHODS: Eighty-six patients undergoing liver resections were included in a prospective randomized study comparing the intra- and postoperative course under CPC (n = 42) or IPC (n = 44) with periods of 15 minutes of clamping and 5 minutes of unclamping. The data were further analyzed according to the presence (steatosis >20% and chronic liver disease) or absence of abnormal liver parenchyma. RESULTS: The two groups of patients were similar in terms of age, sex, nature of the liver tumors, results of preoperative assessment, proportion of patients undergoing major or minor hepatectomy, and nature of nontumorous liver parenchyma. Intraoperative blood loss during liver transsection was significantly higher in the IPC group. In the CPC group, postoperative liver enzymes and serum bilirubin levels were significantly higher in the subgroup of patients with abnormal liver parenchyma. Major postoperative deterioration of liver function occurred in four patients with abnormal liver parenchyma, with two postoperative deaths. All of them were in the CPC group. CONCLUSIONS: This clinical controlled study clearly demonstrated the better parenchymal tolerance to IPC over CPC, especially in patients with abnormal liver parenchyma.  (+info)

Prolonged continuous or intermittent vascular inflow occlusion during hemihepatectomy in pigs. (7/2543)

OBJECTIVE: To assess ischemia and reperfusion (I/R) injury in a hemihepatectomy model in pigs after prolonged continuous or intermittent vascular inflow occlusion in the liver. SUMMARY BACKGROUND DATA: Massive intraoperative blood loss during liver resections can be prevented by temporary vascular inflow occlusion, consequently leading to ischemia and reperfusion injury in the remnant liver. Previously, in a pig liver resection model in which only limited I/R injury was induced during brief (90 min) vascular inflow occlusion, the authors demonstrated reduced I/R injury after continuous (CNT) occlusion, compared to intermittent (INT). This liver resection study on pigs was undertaken to assess I/R injury after prolonged (120 min) CNT or INT occlusion. METHODS: In pigs (37.0 +/- 1.5 kg), liver ischemia during 2 hours was CNT (n = 6) or INT (n = 6) (eight subsequent periods of 12 min ischemia and 3 min recirculation), followed by 6 hours of reperfusion. A left hemihepatectomy (45.5% +/- 1.4%) was performed within the first 12 minutes of ischemia. No hepatic pedicle clamping or liver resection was performed in control experiments (n = 6). Microvascular damage was assessed by hyaluronic acid (HA) uptake capacity of the liver (parameter of early sinusoidal endothelial cell damage) and restoration of intrahepatic tissue pO2 during reperfusion. Hepatocellular damage was tested by plasma concentrations of aspartate aminotransferase (AST), alanine aminotransferase, and lactate dehydrogenase (LDH). RESULTS: Hyaluronic acid uptake after 6 hours of reperfusion, compared to preischemic uptake, was unaltered in the control group, but was significantly reduced in both resection groups. However, more HA was taken up after INT occlusion, compared to CNT (60.4% +/- 5.6% and 39.5% +/- 3.7%, respectively; ANOVA: p = 0.001). Intrahepatic tissue pO2 distribution after 6 hours of reperfusion more closely returned to preischemic configuration in the INT group than in the CNT group, indicating reduced microcirculatory disturbances after INT occlusion. Release of AST and LDH after 6 hours of reperfusion was significantly increased in both CNT and INT groups. Lower AST levels, however, were found after INT occlusion than after CNT occlusion (267.0 +/- 74.7 U/l and 603.3 +/- 132.4 U/l, respectively; p = 0.06). CONCLUSIONS: Intermittent hepatic vascular inflow occlusion during prolonged liver ischemia in pigs resulted in less microcirculatory and hepatocellular injury, compared to continuous occlusion. Intermittent clamping is preferable when prolonged periods of vascular inflow occlusion are applied during liver resections.  (+info)

Quercetin inhibited DNA synthesis and induced apoptosis associated with increase in c-fos mRNA level and the upregulation of p21WAF1CIP1 mRNA and protein expression during liver regeneration after partial hepatectomy. (8/2543)

Quercetin, a widely distributed bioflavonoid, inhibited DNA synthesis in regenerating liver after partial hepatectomy. This inhibition was accompanied by apoptosis, evidenced by in situ end-labeling and gel electrophoresis of DNA fragmentation. Characteristic DNA fragmentation was detected as early as 2 h after injection. Northern blot analysis revealed that quercetin induced the increases in c-fos and p21WAF1CIP1 mRNA levels within 2 h. The expression of p21 protein was also enhanced, while p53 mRNA and protein levels were not affected by quercetin. These results suggest that quercetin-induced apoptosis is associated with the increase in c-fos mRNA level and the upregulation of p21 mRNA and protein expression, probably in a p53-independent pathway.  (+info)

Preoperative portal vein embolization with a new liquid embolic agent<...Preoperative portal vein embolization with a new liquid embolic agent<...
TY - JOUR. T1 - Preoperative portal vein embolization with a new liquid embolic agent. AU - Ko, Gi Young. AU - Sung, Kyu Bo. AU - Yoon, Hyun Ki. AU - Kim, Jeong Ho. AU - Weon, Young Cheol. AU - Song, Ho Young. PY - 2003/5/1. Y1 - 2003/5/1. N2 - PURPOSE: To evaluate the effectiveness and safety of a new liquid embolic agent in preoperative portal vein embolization. MATERIALS AND METHODS: Embol-78 was obtained by means of hydrolysis of polyvinyl acetate and was dissolved in a mixture of ethanol and nonionic water-soluble contrast medium. After percutaneous puncture of the portal vein, embolization of the right portal vein was performed in 22 patients with hepatocellular carcinoma and in 29 patients with nonhepatocellular carcinoma. In each group, changes in volume of the future liver remnant, portal venous pressure, and liver enzymes were evaluated both before and after embolization. Complications were also evaluated. RESULTS: Portal vein embolization was successful in all patients, without major ...
https://scholars.uthscsa.edu/en/publications/preoperative-portal-vein-embolization-with-a-new-liquid-embolic-a
Role of Laparoscopic Hepatectomy for Hepatocellular Carcinoma - SAGES Abstract ArchivesRole of Laparoscopic Hepatectomy for Hepatocellular Carcinoma - SAGES Abstract Archives
The important considerations in determining indications for laparoscopic hepatectomy include tumor size, type and location. Nodular tumors smaller than 4 cm or pedunculated tumors smaller than 7 cm are suitable candidates. Concerning location, tumors in the lower segment and the left lateral segment are good candidates. Favourable operative procedure are partial hepatectomy and left lateral sectionectomy. Recently, we have successfully experienced of laparoscopic hepatectomy of recurrece HCC, Giant HCC or tumor located upper segment and hemihepatectomy. The operative procedures were 37 partial hepatectomy cases, 20 left lateral segmentectomy cases, 2 S6 segmentectomy , 2 posterior sectionectomy cases, 2 left hemihepatectomy cases and 1 right hemihepatectomy case ...
https://www.sages.org/meetings/annual-meeting/abstracts-archive/role-of-laparoscopic-hepatectomy-for-hepatocellular-carcinoma/
DSpace at EWHA: Laparoscopic major liver resection in Korea: A multicenter studyDSpace at EWHA: Laparoscopic major liver resection in Korea: A multicenter study
Introduction: We report our experience with laparoscopic major liver resection in Korea based on a multicenter retrospective study. Materials and methods: Data from 1,009 laparoscopic liver resections conducted from 2001 to 2011 were retrospectively collected. Twelve tertiary medical centers with specialized hepatic surgeons participated in this study. Results: Among 1,009 laparoscopic liver resections, major liver resections were performed in 265 patients as treatment for hepatocellular carcinoma, metastatic tumor, intrahepatic duct stone, and other conditions. The most frequently performed procedure was left hemihepatectomy (165 patients), followed by right hemihepatectomy (53 patients). Pure laparoscopic procedure was performed in 190 patients including 19 robotic liver resections. Hand-assisted laparoscopic liver resection was performed in three patients and laparoscopy-assisted liver resection in 55 patients. Open conversion was performed in 17 patients (6.4 %). Mean operative time and ...
http://dspace.ewha.ac.kr/handle/2015.oak/223421
Portal Vein Embolization: A Preoperative Approach to Improve the Safety of Major Hepatic Resection | Bentham SciencePortal Vein Embolization: A Preoperative Approach to Improve the Safety of Major Hepatic Resection | Bentham Science
Title: Portal Vein Embolization: A Preoperative Approach to Improve the Safety of Major Hepatic Resection. VOLUME: 2 ISSUE: 4. Author(s):David C. Madoff, Eddie K. Abdalla, Michael J. Wallace, Chaan S. Ng, Dario Ribero and Jean-Nicolas Vauthey. Affiliation:Interventional Radiology Section, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 325, Houston, Texas 77030-4009, USA.. Keywords:future liver remnant (FLR), liver regeneration, Computed tomography (CT), total liver volume (TLV), embolic materials. Abstract: Portal vein embolization (PVE) has become an important tool in the preoperative management of select patients prior to major hepatic resection. PVE redirects portal flow to the intended remnant liver to induce hypertrophy of the nondiseased portion of the liver and thereby may reduce complications and shorten hospital stays after surgery. This article reviews the rationale and existing ...
https://www.eurekaselect.com/58111/article/portal-vein-embolization-preoperative-approach-improve-safety-major-hepatic-resection?tracking-code=4
Effect of Vascular Inflow Occlusion in Open Liver Resection for Hepatocellular Carcinoma - Full Text View - ClinicalTrials.govEffect of Vascular Inflow Occlusion in Open Liver Resection for Hepatocellular Carcinoma - Full Text View - ClinicalTrials.gov
Bleeding is a major problem during liver resection. Vascular inflow occlusion, also known as Pringle maneuver, has been commonly employed to reduce blood loss during liver surgery. However, Pringle maneuver might cause ischaemic insult to the remnant liver and lead to post-operative liver dysfunction.. The investigators hypothesize that liver resection without the use of vascular inflow occlusion (Pringle maneuver) is associated with lower postoperative complications rate.. The aim of this study is to evaluate whether elective open liver resection without vascular inflow occlusion (Pringle Maneuvre) would lead to a reduction of post-operative surgical complications in patient with hepatocellular carcinoma.. Eligible patients undergoing liver resection in the Prince of Wales Hospital will be recruited and randomized into 2 study arms comparing the effect of Pringle maneuver. ...
https://clinicaltrials.gov/ct2/show/NCT01759901
Risk factors for early recurrence after curative hepatectomy for colorectal liver metastases<...
TY - JOUR. T1 - Risk factors for early recurrence after curative hepatectomy for colorectal liver metastases. AU - Yamashita, Yo Ichi. AU - Adachi, Eisuke. AU - Toh, Yasushi. AU - Ohgaki, Kippei. AU - Ikeda, Osamu. AU - Oki, Eiji. AU - Minami, Kazuhito. AU - Sakaguchi, Yoshihisa. AU - Tsujita, Eiji. AU - Okamura, Takeshi. PY - 2011/4/1. Y1 - 2011/4/1. N2 - Purpose. With the broadening indications for hepatectomy to treat colorectal liver metastases (CRLM), early recurrence is a major problem. The aim of this study is to identify risk factors of early recurrence, defi ned as recurrence within 1 year after surgery. Methods. A retrospective analysis was performed on 121 consecutive patients who underwent hepatectomy for CRLM. Results. Among 121 patients, 52 (43.0%) developed early recurrence. The independent risk factor for early recurrence was number of liver metastases ≥3 (odds ratio 2.65). There were signifi cantly more patients with liver recurrence (51.9%) and recurrence beyond curative ...
https://kyushu-u.pure.elsevier.com/ja/publications/risk-factors-for-early-recurrence-after-curative-hepatectomy-for-
Effects of Pringle Maneuver and Partial Hepatectomy on the Pharmacokin by Mohammad K. Miah, Imam H. Shaik et al.Effects of Pringle Maneuver and Partial Hepatectomy on the Pharmacokin by Mohammad K. Miah, Imam H. Shaik et al.
Liver diseases are known to affect the function of remote organs. The aim of the present study was to investigate the effects of Pringle maneuver, which results in hepatic ischemia-reperfusion (IR) injury, and partial hepatectomy (Hx) on the pharmacokinetics and brain distribution of sodium fluorescein (FL), which is a widely used marker of blood-brain barrier (BBB) permeability. Rats were subjected to Pringle maneuver (total hepatic ischemia) for 20 min with (HxIR) or without (IR) 70% hepatectomy. Sham-operated animals underwent laparotomy only. After 15 min or 8 h of reperfusion, a single 25-mg/kg dose of FL was injected intravenously and serial (0-30 min) blood and bile and terminal brain samples were collected. Total and free (ultrafiltration) plasma, total brain homogenate, and bile concentrations of FL and/or its glucuronidated metabolite (FL-Glu) were determined by HPLC. Both IR and HxIR caused significant reductions in the biliary excretions of FL and FL-Glu, resulting in significant increases
https://digitalcommons.chapman.edu/pharmacy_articles/183/
Optimal central venous pressure during partial hepatectomy for hepatocellular carcinoma | Read by QxMDOptimal central venous pressure during partial hepatectomy for hepatocellular carcinoma | Read by QxMD
BACKGROUND: Low central venous pressure (CVP) affects hemodynamic stability and tissue perfusion. This prospective study aimed to evaluate the optimal CVP during partial hepatectomy for hepatocellular carcinoma (HCC).. METHODS: Ninety-seven patients who underwent partial hepatectomy for HCC had their CVP controlled at a level of 0 to 5 mmHg during hepatic parenchymal transection. The systolic blood pressure (SBP) was maintained, if possible, at 90 mmHg or higher. Hepatitis B surface antigen was positive in 90 patients (92.8%) and cirrhosis in 84 patients (86.6%). Pringle maneuver was used routinely in these patients with clamp/unclamp cycles of 15/5 minutes. The average clamp time was 21.4+/-8.0 minutes. These patients were divided into 5 groups based on the CVP: group A: 0-1 mmHg; B: 1.1-2 mmHg; C: 2.1-3 mmHg; D: 3.1-4 mmHg and E: 4.1-5 mmHg. The blood loss per transection area during hepatic parenchymal transection and the arterial blood gas before and after liver transection were ...
https://read.qxmd.com/read/24103283/optimal-central-venous-pressure-during-partial-hepatectomy-for-hepatocellular-carcinoma
Right and extended-right hepatectomies for unilobar colorectal metastases: impact of portal vein embolization on long-term...Right and extended-right hepatectomies for unilobar colorectal metastases: impact of portal vein embolization on long-term...
Portal vein embolization (PVE) is an effective procedure to increase the future remnant liver (FRL) before major hepatectomy. A controversial issue is that PVE may stimulate tumor growth and can be associated with poor prognosis after liver resection for colorectal liver metastases (CRLM). The aim of this study was to evaluate the impact of PVE on long-term survival following major hepatectomy for CRLM.Between 1998 and 2010, 100 right and extended-right hepatectomies for unilobar, right-sided CRLM were performed. Of the group, 20 patients underwent preoperative PVE (group A). The control patients (group B; 20 patients) were selected by matching with the group A patients.It was found that 25 patients (25/40; 62.5\%) had developed tumor recurrence. The rate of global recurrence was not significantly different in groups A and B (65\% vs 60\%, respectively; P = .744). The specific overall intrahepatic recurrence rate was 42.5\% (17 of 40 patients) and was not significantly different in groups A and ...
https://iris.unicas.it/handle/11580/39446
Complete necrosis of hepatocellular carcinoma after preoperative portal vein embolization: a case report | Springer for...Complete necrosis of hepatocellular carcinoma after preoperative portal vein embolization: a case report | Springer for...
Background Hepatocellular carcinoma has a poor prognosis; few patients can undergo surgical curative treatment according to Barcelona Clinic Liver Cancer guidelines. Progress in surgical techniques...
https://rd.springer.com/article/10.1186/s13256-016-1160-8
An Initial Experience with a New Radiofrequency Vessel Sealer in Laparoscopic Liver Resection - SAGES Abstract ArchivesAn Initial Experience with a New Radiofrequency Vessel Sealer in Laparoscopic Liver Resection - SAGES Abstract Archives
Eren Berber, MD. Cleveland Clinic. Objective: Over the last decade, techniques have been developed for laparoscopic liver resection (LLR). Still, one of the drawbacks is the dependency on multiple different devices for various steps of the procedure. Ideal would be to have a device that could be used to divide and provide hemostasis to the parenchyma, while also serving as a vessel sealer. Herein, we demonstrate a new 5 cm radiofrequency vessel sealing/dividing device (Caiman, Aesculap Inc., Center Vllaey, PA) that combines these features for LLR.. Methods: The device was used in 2 recent LLR cases. The first patient had ocular melanoma metastases in segment 3 and the second patient carcinoid metastases to segment 3.. Results: The first patient underwent laparoscopic left lateral sectionectomy using the Caiman vessel sealer and divider. The operation time was 89 minutes with an unremarkable blood loss. She was discharged home on postoperative day (POD) 2 and her drain was removed on POD 7. Final ...
https://www.sages.org/meetings/annual-meeting/abstracts-archive/an-initial-experience-with-a-new-radiofrequency-vessel-sealer-in-laparoscopic-liver-resection/
Preoperative chemotherapy, major liver resection, and transplantation for primary malignancies in children. | DIAL.pr - BOREALPreoperative chemotherapy, major liver resection, and transplantation for primary malignancies in children. | DIAL.pr - BOREAL
Otte, Jean-Bernard ; Aronson, D ; Vraux, H. ; de Ville de Goyet, J ; Reding, Raymond ; et. al. Preoperative chemotherapy, major liver resection, and transplantation for primary malignancies in children.. In: Transplantation proceedings, Vol. 28, no. 4, p. 2393-4 (1996 ...
https://dial.uclouvain.be/pr/boreal/fr/object/boreal%3A26492
AB102. Laparoscopic versus open liver resection for tumours in the posterosuperior segments: a systematic review and meta...AB102. Laparoscopic versus open liver resection for tumours in the posterosuperior segments: a systematic review and meta...
AB102. Laparoscopic versus open liver resection for tumours in the posterosuperior segments: a systematic review and meta-analysis
http://map.amegroups.com/article/view/5381/pdf
Non-heart-beating cadaver donor hepatectomy the operative procedure<...
TY - JOUR. T1 - Non-heart-beating cadaver donor hepatectomy the operative procedure. AU - Olson, Les. AU - Davi, Richard. AU - Barnhart, Jay. AU - Burke, George. AU - Ciancio, Gaetano. AU - Miller, Joshua. AU - Tzakis, Andreas. PY - 1999. Y1 - 1999. KW - Cadaver donors. KW - Hepatectomy. KW - Operative procedure. UR - http://www.scopus.com/inward/record.url?scp=0032984247&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0032984247&partnerID=8YFLogxK. U2 - 10.1034/j.1399-0012.1999.130106.x. DO - 10.1034/j.1399-0012.1999.130106.x. M3 - Article. C2 - 10081644. AN - SCOPUS:0032984247. VL - 13. SP - 98. EP - 103. JO - Clinical Transplantation. JF - Clinical Transplantation. SN - 0902-0063. IS - 1 II. ER - ...
https://miami.pure.elsevier.com/en/publications/non-heart-beating-cadaver-donor-hepatectomy-the-operative-procedu
Hepatectomy | Article about hepatectomy by The Free DictionaryHepatectomy | Article about hepatectomy by The Free Dictionary
Looking for hepatectomy? Find out information about hepatectomy. Surgical removal of the liver or a part of it Explanation of hepatectomy
https://encyclopedia2.thefreedictionary.com/hepatectomy
Eline Aas - Institutt for helse og samfunn
Fretland, Åsmund Avdem; Dagenborg, Vegar Johansen; Bjørnelv, Gudrun Maria Waaler; Kazaryan, Airazat M.; Kristiansen, Ronny; Fagerland, Morten; Hausken, John; Tønnessen, Tor Inge; Abildgaard, Andreas; Barkhatov, Leonid; Yaqub, Sheraz; Røsok, Bård Ingvald; Bjørnbeth, Bjørn Atle; Andersen, Marit Helen; Flatmark, Kjersti; Aas, Eline & Edwin, Bjørn (2018). Laparoscopic Versus Open Resection for Colorectal Liver Metastases: The OSLO-COMET Randomized Controlled Trial. Annals of Surgery. ISSN 0003-4932. 267(2), s 199- 207 . doi: 10.1097/SLA.0000000000002353 Vis sammendrag Objective: To perform the first randomized controlled trial to compare laparoscopic and open liver resection. Summary Background Data: Laparoscopic liver resection is increasingly used for the surgical treatment of liver tumors.However, high-level evidence to conclude that laparoscopic liver resection is superior to open liver resection is lacking. Methods: Explanatory, assessor-blinded, single center, randomized superiority ...
https://www.med.uio.no/helsam/personer/vit/elineaa/index.html
Preoperative Glucocorticoid Use in Major Hepatectomy - Full Text View - ClinicalTrials.govPreoperative Glucocorticoid Use in Major Hepatectomy - Full Text View - ClinicalTrials.gov
Background: Reducing postoperative complications remains a dominant challenge for all clinicians. By minimizing the incidence of adverse outcomes, health care costs and patient recovery can be improved. A number of studies have documented that fewer postoperative adverse events occur with the preoperative use of glucocorticoids (GC). Two small manuscripts support the use of GC with particular reference to liver resection.. Major hepatectomy can be associated with numerous adverse outcomes (hemorrhage, bile leak, liver failure, wound infection other infectious complications). This rate approaches 54% in some trials. Additionally, the liver is responsible for numerous metabolic functions and actively participates in the acute phase response via the generation of inflammatory mediators and cytokines. Glucocorticoids play an important role in suppressing the over-synthesis of pro-inflammatory cytokines and therefore may assist in reducing postoperative complications. These pro-inflammatory cytokines ...
https://clinicaltrials.gov/ct2/show/NCT01997658?recr=Open&intr=%22Glucocorticoids%22&rank=15
Laparoscopic Live Donor Hepatectomy: Random Mutation or Stepwise Evolution? - Akoad - 2013 - American Journal of...Laparoscopic Live Donor Hepatectomy: Random Mutation or Stepwise Evolution? - Akoad - 2013 - American Journal of...
Totally laparoscopic living donor hepatectomy is a complex procedure with a steep learning curve requiring experienced teams with a commitment to technical excellence; it is not a random act but rather a gradual evolutionary process, decades in the making. See case reports by Samstein et al (page 2462), Soubrane et al (page 2467) and Troisi et al (page 2472). ...
http://onlinelibrary.wiley.com/doi/10.1111/ajt.12363/abstract
Prognosis of One-stage Hepatectomy for Bilobar Colorectal MetastasesPrognosis of One-stage Hepatectomy for Bilobar Colorectal Metastases
It is not rare that two-stage hepatectomy for multiple bilobar colorectal liver metastases (CLM) be left incomplete because of disease progression or te
http://www.knowcancer.com/cancer-trials/NCT01683357/
Liver echinococcus | Partial liver resection. Surgery: Treatment in Germany, Marburg hospitals on BookingHealth.comLiver echinococcus | Partial liver resection. Surgery: Treatment in Germany, Marburg hospitals on BookingHealth.com
Liver echinococcus | Partial liver resection. Surgery: Treatment in Marburg, Germany ✈. Prices on BookingHealth.com - booking treatment online!
https://bookinghealth.com/programs/treatment/surgery/liver-echinococcus-partial-liver-resection/germany/marburg
MEDLINE - Resultado p gina 1
Small for size and flow syndrome (SFSF) is one of the most challenging complications following extended hepatectomy (EH). After EH, hepatic artery flow decreases and portal vein flow increases per 100 g of remnant liver volume (RLV). This causes hypoxia followed by metabolic acidosis. A correlation between acidosis and posthepatectomy liver failure has been postulated but not studied systematically in a large animal model or clinical setting. In our study, we performed stepwise liver resections on nine pigs to defined SFSF limits as follows: step 1: segment II/III resection, step 2: segment IV resection, step 3: segment V/VIII resection (RLV: 75, 50, and 25%, respectively). Blood gas values were measured before and after each step using four catheters inserted into the carotid artery, internal jugular vein, hepatic artery, and portal vein. The pH, [Formula: see text], and base excess (BE) decreased, but [Formula: see text] values increased after 75% resection in the portal and jugular veins. EH ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=G02.111.007
Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in...Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in...
Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in patients with hepatocellular carcinoma : Liver resection for hepatocellular carcinoma (HCC) has the highest local controllability among all local treatments and results in a good survival rate. However, the recurrence rates of HCC continue to remain high even after curative hepatectomy Moreover, it has been reported that some patients with HCC have an early death due to recurrence. We analyzed the preoperative risk factors for early
http://www.youscribe.com/catalogue/documents/savoirs/analysis-of-the-risk-factors-for-early-death-due-to-disease-2050887
Laparoscopic surgery for large left lateral liver tumors: safety and oncologic outcomes<...
TY - JOUR. T1 - Laparoscopic surgery for large left lateral liver tumors. T2 - safety and oncologic outcomes. AU - Yang, Tsung-Han. AU - Chen, Jen Lung. AU - Lin, Yih-Jyh. AU - Chao, Ying-Jui. AU - Shan, Yan-Shen. AU - Hsu, Hui-Ping. AU - Su, Che-Min. AU - Chou, Chung Ching. AU - Yen, Yi-Ting. PY - 2018/10/1. Y1 - 2018/10/1. N2 - Background: Although laparoscopic hepatectomy has been proven to be safe and reliable, the influence of tumor size on the feasibility of laparoscopic left lateral segmentectomy (LLLS) is unclear. We retrospectively reviewed our surgical results focusing on hepatic tumor located in the left lateral segment. Methods: From January 2003 to June 2016, patients who underwent left lateral segmentectomy were retrospectively reviewed, and data were collected on patient characteristics, peri-operative outcomes, and pathologic results. Patients with intrahepatic stone, cystic lesion, or unmeasurable tumor size were excluded. The continuous variables were compared using the ...
https://researchoutput.ncku.edu.tw/zh/publications/laparoscopic-surgery-for-large-left-lateral-liver-tumors-safety-a
Partial hepatectomy for primary hepatic melanoma: a report of two cases and review of the literature | World Journal of...Partial hepatectomy for primary hepatic melanoma: a report of two cases and review of the literature | World Journal of...
Malignant melanoma is an extremely aggressive cancer arising from melanocytes, associated with the development of metastases in up to 20% of patients. Although the liver is a frequent metastatic site of malignant melanoma, primary hepatic melanoma (PHM) is rare. The treatment of PHM is controversial, and the prognosis for affected patients remains poor. We present two PHM patients who underwent partial hepatectomy at our institution and review the clinical and pathological data from these cases. Our results suggest that it is difficult to make a preoperative diagnosis of PHM without pathological results. For patients with resectable PHM, surgical resection is a potentially curative treatment.
https://wjso.biomedcentral.com/articles/10.1186/1477-7819-12-362/figures/1
Differential Effects of Three Techniques for Hepatic Vascular Exclusion during Resection for Liver Cirrhosis on Hepatic...Differential Effects of Three Techniques for Hepatic Vascular Exclusion during Resection for Liver Cirrhosis on Hepatic...
Gastroenterology Research and Practice is a peer-reviewed, Open Access journal that provides a forum for researchers and clinicians working in the areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis, and therapy of gastrointestinal diseases.
https://www.hindawi.com/journals/grp/2018/5309286/ref/
HKU Scholars Hub: Short-term cardiotrophin-1 (CT-1) rescues marginalcirrhotic liver remnant after major hepatectomywithout...HKU Scholars Hub: Short-term cardiotrophin-1 (CT-1) rescues marginalcirrhotic liver remnant after major hepatectomywithout...
Background Hepatic resection is not applicable to the majority ofhepatocellular carcinoma (HCC) patients due to insufficient liverfunction reserve. Cardiotrophin-1 (CT-1), a member of the inter-leukin-6 family, has demonstrated protective and pro-proliferativeeffects in the myocytes and hepatocytes.Aim The present study aimed to investigate the potential role ofCT-1 in rescuing marginal cirrhotic liver remnant in a rat orthotopicHCC model.Materials and Methods Liver cirrhosis was induced by subcuta-neous injection of CCL4 for 8 weeks. The rat orthotopic HCC model was generated by injecting HCC cells into the left lobe of the liver.Animals received the following treatments: 1) hepatectomy only, n =6; 2) CT-1 (2 µg/kg) intraportal vein injection (i.pv) right after hepa-tectomy, n = 6; 3) CT-1 (2 µg/kg) i.pv right after hepatectomy, and 1µg/kg intraperitoneal injection (i.p) 24 hr after hepatectomy, n = 6; 4)CT-1 (2 µg/kg) i.p 24 hr before hepatectomy, n = 6; 5) CT-1 (2 µg/kg)i.p 24 hr before ...
http://repository.hku.hk/handle/10722/107160
Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat |...Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat |...
Type beta transforming growth factor (TGF-beta), a factor produced by many cell types, is a potent inhibitor of hepatocyte DNA synthesis in vitro. To determine whether TGF-beta can influence hepatocyte proliferation in vivo, its effects were examined on the regenerative response of liver to partial hepatectomy (PH) in the rat. Porcine platelet-derived TGF-beta 1 (0.5 micrograms), administered intravenously at the time of PH and 11 hr later, reduced the fraction of hepatocytes engaged in DNA synthesis 22 hr after PH by 67% and inhibited the rate of hepatic [3H]thymidine incorporation by 50%. TGF-beta 2 produced a similar effect. A single dose of 0.5 micrograms of TGF-beta 1 given 11 hr after PH reduced liver [3H]thymidine incorporation by 32%; 4.5 micrograms of TGF-beta 1 or TGF-beta 2 inhibited DNA synthesis by 88% and the labeling index by 86%. Although sensitive to TGF-beta administered 11 hr after PH, late in the G1 phase of the cell cycle, a single dose of 0.5 micrograms given at the time of ...
https://www.pnas.org/content/85/14/5126?ijkey=00636257533b60f9279597d88ce00eb5e8683623&keytype2=tf_ipsecsha
The ALPPS risk score: Avoiding futile use of ALPPS - Zurich Open Repository and ArchiveThe ALPPS risk score: Avoiding futile use of ALPPS - Zurich Open Repository and Archive
OBJECTIVES To create a prediction model identifying futile outcome in ALPPS (Associating Liver Partition and Portal vein ligation for Staged hepatectomy) before stage 1 and stage 2 surgery. BACKGROUND ALPPS is a 2-stage hepatectomy, which incorporates parenchymal transection at stage 1 enabling resection of extensive liver tumors. One of the major criticisms of ALPPS is the associated high mortality rate up to 20%. METHODS Using the International ALPPS Registry, a risk analysis for futile outcome (defined as 90-day or in-hospital mortality) was performed. Futility was modeled using multivariate regression analysis and a futility risk score formula was computed on the basis of the relative size of logistic model regression coefficients. RESULTS Among 528 ALPPS patients from 38 centers, a futile outcome was observed in 47 patients (9%). The pre-stage 1 model included age 67 years or older [odds ratio (OR) = 5.7], and tumor entity (OR = 3.8 for biliary tumors) as independent predictors of futility ...
https://www.zora.uzh.ch/id/eprint/125497/
RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-α and NF-κB | Journal of Experimental...RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-α and NF-κB | Journal of Experimental...
Transgenic mice expressing DN RAGE in cells of MP lineage display enhanced survival and liver regeneration after massive hepatectomy. Transgenic mice expressing human DN RAGE selectively in cells of MP lineage using the scavenger receptor type A promoter were used for these studies. (A-D) Immunofluorescence microscopy. Immunofluorescence for detection of RAGE antigen was performed in sections prepared from the remnants of transgenic mice 8 h after sham surgery (A) or massive resection (B, 85%). Double immunofluorescence staining was performed on sections prepared from transgenic mice 8 h after massive resection using the following antibodies: anti-RAGE IgG (C and D, green) and anti-CD68 IgG (C, red) or anti-CD11c IgG (D, red). Single and merged images are shown. (A and B) Bars, 100 μm; (C and D) Bars, 50 μm. (E) Kaplan-Meier Product Limit Estimate. The times of death were recorded for transgenic versus littermate control mice undergoing massive hepatectomy and survival was plotted. (F and G) ...
https://rupress.org/jem/article/201/3/473/52401/RAGE-limits-regeneration-after-massive-liver
Expression in liver sinusoidal endothelial cells, partial hepatectomy, 30hr, biol rep3.CNhs14506.13603-146F3 - EpiFactors...Expression in liver sinusoidal endothelial cells, partial hepatectomy, 30hr, biol rep3.CNhs14506.13603-146F3 - EpiFactors...
Expression of epigenetic factors in liver sinusoidal endothelial cells, partial hepatectomy, 30hr, biol_rep3 (CNhs14506.13603-146F3)
https://epifactors.autosome.ru/samples/CNhs14506
Diagnosis and treatment of cancer of the bile duct with partial hepatectomy: Costs for treatment #275070 in Switzerland |...Diagnosis and treatment of cancer of the bile duct with partial hepatectomy: Costs for treatment #275070 in Switzerland |...
Diagnosis and treatment of cancer of the bile duct with partial hepatectomy (costs for program #275070) ✔ Klinik Im Park ✔ Department of General and Abdominal Surgery ✔ BookingHealth.com
https://bookinghealth.com/klinik-im-park/treatment-programs/275070-diagnosis-and-treatment-of-cancer-of-the-bile-duct-with-partial-hepatectomy.html
KoreaMedKoreaMed
In total, 248 patients were diagnosed with recurred liver metastasis between January 2003 and May 2016. Second and third hepatectomies were performed in 70 and 7 patients, respectively. The other 171 patients did not undergo a repeat hepatectomy. Clinical features were collected from the medical records. We analyzed survival rates of the repeat hepatectomy group and the nonrepeat hepatectomy group. We also investigated factors affecting overall and disease-free survival of patients who received a repeat hepatectomy using univariate and multivariate analyses ...
https://www.koreamed.org/SearchBasic.php?RID=2450984
Most recent papers with the keyword Surgeons and hepatitis | Read by QxMDMost recent papers with the keyword Surgeons and hepatitis | Read by QxMD
Right hepatectomy is a standard anatomical procedure used worldwide, and consists of two important steps: access to the portal pedicle at the hepatic hilus and approach through the right hepatic vein. With interest in the early work in the field of right hepatectomy, we searched for official documents, published not only in English but also non-English languages for insights on the history of the great work conducted by pioneer liver surgeons in the East and West. To discuss anatomical right hepatectomy, it is important to consider several issues, including liver anatomy, other anatomical liver resection procedures, control of vascular in-flow and out-flow, operative procedures or approaches, preoperative management and other related issues ...
https://www.readbyqxmd.com/keyword/31066
Plus itPlus it
Changes in binding of dexamethasone (9α-fluoro-11β, 17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione) to its receptors in regenerating rat liver after 70% hepatectomy were examined. Specific receptors for dexamethasone in the liver remnants of adrenalectomized rats decreased significantly during the period of DNA synthesis after 70% hepatectomy; then, they increased to above the control values between Days 4 and 7 after partial hepatectomy and subsequently returned to the control values. During the period of DNA synthesis, decreased binding was observed in partially hepatectomized rats with or without adrenals, but later enhanced binding was not prominent in rats with adrenals.. ...
http://cancerres.aacrjournals.org/content/39/12/5132
Reply to: Re: Intraoperative ultrasonography during planned liver resections remains an important surgical tool ((2007) 21:...Reply to: Re: Intraoperative ultrasonography during planned liver resections remains an important surgical tool ((2007) 21:...
Ellsmere, J., Kane, R. & Jones, D.B. Reply to: Re: Intraoperative ultrasonography during planned liver resections remains an important surgical tool ((2007) 21: 1280-1283). Surg Endosc 22, 1913 (2008). https://doi.org/10.1007/s00464-008-9942-8. Download ...
https://rd.springer.com/article/10.1007%2Fs00464-008-9942-8
Hidatidosis of the SpleenHidatidosis of the Spleen
|p||p|Hydatidosis of the spleen (SH) is an extremally rare condition.|/p||p||bold|The aim of the study|/bold| was to present our experience and discuss diagnostic methods and therapeutical options in cases of spleen hydatidosis.|/p||p||bold|Material and methods.|/bold| Between 1993 and 2008, 8 patients were diagnosed with SH, 6 of whom were operated on (4 males and 2 females). Their average age was 44.5 years (the age range 30-59 years). Four patients presented isolated SH, one had a spleen and liver hydatidosis and there was also a case of one spleen, liver and peritoneal hydatidosis.|/p||p||bold|Results.|/bold| The main symptom of the condition was abdominal pain and hydatidosis serology was always positive. The average hydatidisis cyst size was 13.3 cm (range: 7-18 cm). Splenectomy was performed in 5 cases and a partial cystectomy in one case. A left lateral sectionectomy was required in 1 case, a segment III subsegmentectomy was delivered in 1 case and multiple cystectomies in the
https://www.infona.pl/resource/bwmeta1.element.-psjd-doi-10_2478_v10035-011-0042-4
The Egyptian Journal of Surgery : Table of Contents
Introduction Women with visceral metastases of breast cancer are usually considered to have a poor prognosis. A small subgroup of patients, however, present with liver metastases as the only manifestation of recurrence. The discussion whether this subgroup might benefit from an aggressive approach including liver resection is still ongoing and remains controversial. The decrease in mortality and morbidity rates has led to a broadening of the indication for hepatic resection. Design This was a case series study. Methodology Between January 2011 and December 2013, nine adult female patients underwent liver resection for liver metastases from breast cancer. Patients were considered for surgical management if they were fit for major operation; hepatic resection can be performed with adequate residual liver volume, intact inflow and outflow, and biliary drainage, and no extrahepatic disease on preoperative imaging except for limited and stable bone metastases. Hepatic resection was performed using ...
http://www.ejs.eg.net/showbackissue.asp?issn=1110-1121
Hepatology Archives - Healthcare News & Stories | Blog on Specialty Based Treatments | Aster HospitalsHepatology Archives - Healthcare News & Stories | Blog on Specialty Based Treatments | Aster Hospitals
The first major liver resection (right hepatectomy) was performed by the ILC Team at Aster Hospital, Mankhool on a 28-year-old female who was incidentally detected to have an 11 cm hepatocellular carcinoma (HCC) in the right lobe of the liver. […]. ...
https://asterhospital.com/blog/category/hepatology/
Utility of FDG-PET Scan on the Selection of Patients for Resection of Hepatic Colorectal MetastasesUtility of FDG-PET Scan on the Selection of Patients for Resection of Hepatic Colorectal Metastases
Objective(s) of the proposed study: - The evaluation of the efficiency of 18F deoxyglucose-Positron Emission Tomography (FDG-PET) in stag
http://www.knowcancer.com/cancer-trials/NCT00119899/
PPAR, Non-Selective - Extracellular ATP inhibits chloride channelsPPAR, Non-Selective - Extracellular ATP inhibits chloride channels
Furthermore to these suggestions, diagnostic requirements including history of hepatitis; imaging features as given by the Liver organ Imaging Confirming and Data Program (LI-RADS) that are of help in evaluation of RHCC; previous RHCC recognition using BALAD and GALAD ratings; risk elements predicting RHCC after major resection; hepatectomy methods that lessen recurrence; and adjuvant treatments including antiviral real estate agents, molecular targeted therapy, systemic chemotherapy, and immunotherapy are referred to. Until now, proof supporting most therapeutic options for RHCC has been limited to cohort investigations. Randomized controlled studies have been few. Treatments have not been compared in terms of use at specific tumor stages. As a result, treatments useful for major tumors including medical resection frequently, liver organ transplantation, TACE, regional ablative therapy, and radiotherapy have already been put on recurrences empirically. As opposed to RHCC, many treatment ...
https://chloridechannels.com/category/ppar-non-selective/
Workshops · SURGICONWorkshops · SURGICON
Hepatic resections are performed as a part of the surgical management for benign or malignant pathologies of the liver, while most of them are primary or secondary liver tumors. With the aid of this workshop, you will learn about the different types of hepatic resections, recall some of the liver anatomy and even test your knowledge of the hepatic blood supply and distribution. After laying the theoretical foundation, you will perform typical and atypical hepatic resections, and you will also become more familiar with the Pringle manoeuvre.. ...
https://www.surgicon.ro/workshops
LigaSure versus CUSA for parenchymal transection during laparoscopic hepatectomy in hepatocellular carcinoma patients with...LigaSure versus CUSA for parenchymal transection during laparoscopic hepatectomy in hepatocellular carcinoma patients with...
BACKGROUND: LigaSure has been reported as a safe and effective approach for parenchymal transection in open hepatectomy; however, its roles in laparoscopic hepatectomy (LH) with liver cirrhosis have not been evaluated. The aim of this study was to compare the outcomes of LigaSure vs. Cavitron Ultrasonic Surgical Aspirator (CUSA) for LH in hepatocellular carcinoma (HCC) patients with cirrhosis.. METHODS: We retrospectively reviewed the medical records of 135 HCC patients with background cirrhosis who underwent pure LH using CUSA (n = 55) or LigaSure (n = 80) for parenchymal transection between January 2015 and May 2017 at West China Hospital of Sichuan University. We performed 1:1 propensity score matching between the LigaSure and CUSA groups. Subsequently, 48 patients were included in each group.. RESULTS: The mean parenchymal transection time (74.3 ± 23.6 vs. 86.3 ± 25.8 min, P = 0.019) in the LigaSure group was obviously shorter than that in the CUSA group. The LigaSure did not increase the ...
https://read.qxmd.com/read/29124405/ligasure-versus-cusa-for-parenchymal-transection-during-laparoscopic-hepatectomy-in-hepatocellular-carcinoma-patients-with-cirrhosis-a-propensity-score-matched-analysis
Readmission and Reoperation After Living Donor Hepatectomy. - ATC AbstractsReadmission and Reoperation After Living Donor Hepatectomy. - ATC Abstracts
Background: Living donor liver transplantation remains the predominant option for patients with acute or chronic liver failure in many regions with poor cadaveric donation rates. Over the years, the donor mortality and donor liver failure has been minimized due to improvement in selection and surgical expertise. However like any major liver resections, the risk of bleeding, reoperations and readmissions remains. Aim: Analysis of Reoperation and Readmission rates following Living Donor Hepatectomy from a single center from Western India. Methods: Retrospective analysis of records of living donors who required re-exploration and / or readmissions after Living donor hepatectomy performed between April 2013 & October 2016 at a single center. Results: 137 Donor hepatectomies were done during this period (121 Right Liver grafts and 16 Left lobe and Left lateral segment grafts). The mean age of Donors was 36 years (20 to 58) with a male preponderance ( M/F :1.6/1). There was no mortality (30 day and 90 ...
https://atcmeetingabstracts.com/abstract/readmission-and-reoperation-after-living-donor-hepatectomy/
Comparison of acute kidney injury between open and laparoscopic liver resection: Propensity score analysis. | Physicians...Comparison of acute kidney injury between open and laparoscopic liver resection: Propensity score analysis. | Physicians...
The inflammatory response has been shown to be a major contributor to acute kidney injury. Considering that laparoscopic surgery is beneficial in reducing the inflammatory response, we compared the incidence of postoperative acute kidney injury between laparoscopic liver resection and open liver resection. Among 1173 patients who underwent liver resection surgery, 222 of 926 patients who underwent open liver resection were matched with 222 of 247 patients who underwent laparoscopic liver resection, by using propensity score analysis. The incidence of postoperative acute kidney injury assessed according to the creatinine criteria of the Kidney Disease: Improving Global Outcomes definition was compared between those 1:1 matched groups. A total 77 (6.6%) cases of postoperative acute kidney injury occurred. Before matching, the incidence of acute kidney injury after laparoscopic liver resection was significantly lower than that after open liver resection [1.6% (4/247) vs. 7.9% (73/926), P < 0.001]. ...
https://www.physiciansweekly.com/comparison-of-acute-kidney-injury-between-open-and-laparoscopic-liver-resection-propensity-score-analysis/
Comparison of Pure Laparoscopic vs Open Living Donor Right Hepatectomy - ATC AbstractsComparison of Pure Laparoscopic vs Open Living Donor Right Hepatectomy - ATC Abstracts
Background With the development of laparoscopic skills, its application has expanded in living donor liver transplantation. However, due to technical difficulties, pure laparoscopic donor hepatectomy (PLDH) is performed few centers. In this report, we compare the safety and early outcomes of PLDH and open donor hepatectomy (ODH). Moreover, the learning curve of each group was analyzed and compared during the experienced period.. Methods Total of 78 consecutive living liver donors underwent the right hepatectomy from January 2010 to March 2017. Of these, 43 living donors underwent the ODH and the 35 donors underwent the PLDH. Two donors of the PLDH group underwent open conversion due to bleeding and large graft size. The learning curve was defined using the moving average method.. Results Except for the size of the right portal vein (PLDH 13.4± 6.3 mm, ODH 10.8± 3.2; p=0.03) donor demographic including age, sex, body mass index (BMI), fatty change and vascular and biliary anomaly were ...
https://atcmeetingabstracts.com/abstract/comparison-of-pure-laparoscopic-vs-open-living-donor-right-hepatectomy/
Hand-Assisted Laparoscopic Hepatectomy for Solid Tumor in the Posterior Portion of the Right Lobe: Initial Experience<...
TY - JOUR. T1 - Hand-Assisted Laparoscopic Hepatectomy for Solid Tumor in the Posterior Portion of the Right Lobe. T2 - Initial Experience. AU - Huang, Ming Te. AU - Lee, Wei Jei. AU - Wang, Weu. AU - Wei, Po Li. AU - Chen, Robert J.. PY - 2003/11. Y1 - 2003/11. N2 - Objective: To prove the feasibility of hand-assisted laparoscopic liver resection for tumors located in the posterior portion of the right hepatic lobe. Summary Background Data: Use of laparoscopic liver resection remains limited due to problems with technique, especially when the tumor is located near the diaphragm, or in the posterior portion of the right lobe. Methods: Between October 2001 and June 2002, a total of 7 patients with solid hepatic tumors involving the posterior portion of the right lobe of liver underwent hand-assisted laparoscopic hepatectomy with the HandPort system at our hospital. Surgical techniques used included CO2 pneumoperitoneum and the creation of a wound on the right upper quadrant of the abdomen for ...
https://tmu.pure.elsevier.com/en/publications/hand-assisted-laparoscopic-hepatectomy-for-solid-tumor-in-the-pos
The role of lipopolysaccharide/Toll-like Receptor 4 signalling pathway during liver regeneration after partial hepatectomy in...The role of lipopolysaccharide/Toll-like Receptor 4 signalling pathway during liver regeneration after partial hepatectomy in...
The process of liver regeneration after partial hepatectomy is very complex and is associated with signalling cascades involving initiation signals, transcription factors, cytokines, growth factors, tissue remodelling and termination of growth related signals. To date the exact mechanism of liver regeneration remains poorly understood. Toll-like receptor 4 (TLR4) acts as a sensor for immune signals and plays a critical role in host defence. It is known that lipopolysaccharide (LPS) is one of the ligands for TLR4. Binding of LPS to TLR4 leads to activation of transcription factor, nuclear factor kappa B (NF-κB) via the intracellular adaptor molecule, myeloid differentiation factor 88 (MyD88), which in turn activates the production of proinflammatory cytokines, TNF-α and IL-6. Evidence suggests that LPS/TLR4 signalling may be involved in liver regeneration following partial hepatectomy, as delayed liver regeneration and impaired cytokine responses were observed in C3H/HeJ mice, a mouse that is ...
https://ourarchive.otago.ac.nz/handle/10523/1695
GMS | 131. Kongress der Deutschen Gesellschaft für Chirurgie | Is tumor infiltration to the right portal vein a...
Introduction: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been successfully applied to increase the future liver remnant before a right trisectionectomy. Tumor infiltration to the right portal vein is a challenge situation. Material and methods: A patient with advanced gallbladder carcinoma underwent exploration. Intraoperative finding showed tumor infiltration of the right portal vein and the duodenum. In-situ split of the left lateral liver lobe combined with postoperative right portal vein embolization completed the concept of ALPPS.. Results: Successful right trisectionectomy in combination with whipple operation without tumor residual could be achieved 8 days later, while the liver remnant increased from 491 ml to 911 ml. Neither post-hepatectomy liver failure nor postoperative anastomotic leak has been observed. 3 month follow up has not shown any sign of tumor recurrence. Conclusion: In-situ split combined with postoperative right portal vein ...
http://www.egms.de/static/en/meetings/dgch2014/14dgch202.shtml
Studies on the hyperplasia (regeneration) of the rat liver following partial hepatectomy. Changes in lipid peroxidation and...Studies on the hyperplasia (regeneration) of the rat liver following partial hepatectomy. Changes in lipid peroxidation and...
Studies on the hyperplasia (regeneration) of the rat liver following partial hepatectomy. Changes in lipid peroxidation and general biochemical aspects
http://nparc.nrc-cnrc.gc.ca/eng/view/object/?id=e371fa40-c25c-4724-bf81-23f6a10d7b8e
Chylous ascites following liver resection - Case report | ScholarBank@NUSChylous ascites following liver resection - Case report | [email protected]
Prabhakaran, K.,Patankar, Jahoorahmad M.V.,Neo, Grace T.H. (2004). Chylous ascites following liver resection - Case report. Pediatric Surgery International 20 (9) : 719-721. [email protected] Repository. https://doi.org/10.1007/s00383-004-1281-9 ...
http://scholarbank.nus.edu.sg/handle/10635/29277
Anterior portion of left medial segment IV of liver | definition of anterior portion of left medial segment IV of liver by...Anterior portion of left medial segment IV of liver | definition of anterior portion of left medial segment IV of liver by...
Looking for online definition of anterior portion of left medial segment IV of liver in the Medical Dictionary? anterior portion of left medial segment IV of liver explanation free. What is anterior portion of left medial segment IV of liver? Meaning of anterior portion of left medial segment IV of liver medical term. What does anterior portion of left medial segment IV of liver mean?
https://medical-dictionary.thefreedictionary.com/anterior+portion+of+left+medial+segment+IV+of+liver
Portal vein embolization - WikipediaPortal vein embolization - Wikipedia
Portal vein embolization (PVE) is a preoperative procedure performed in interventional radiology to initiate hypertrophy of the anticipated future liver remnant a couple weeks prior to a major liver resection procedure. The procedure involves injecting the right or left portal vein with embolic material to occlude portal blood flow. By occluding the blood flow to areas of the liver that will be resected away, the blood is diverted to healthy parts of the liver and induces hyperplasia. This may allow for a more extensive resection or stage bilateral resections that would otherwise be contraindicated resulting in better oncological treatment outcomes. Indications for PVE depend on the ratio of future liver remnant (FLR) to total estimated liver volume (TELV) and liver condition. Although there is no consensus to the absolute minimum liver volume required for adequate post-resection liver function, a FLR/TELV ratio of at least 25% in recommended in patients with otherwise normal livers. The ...
https://en.wikipedia.org/wiki/Portal_vein_embolization
Serum arterial lactate concentration predicts mortality and organ dysfunction following liver resection | Perioperative...Serum arterial lactate concentration predicts mortality and organ dysfunction following liver resection | Perioperative...
The aim of this study was to determine if the post-operative serum arterial lactate concentration is associated with mortality, length of hospital stay or complications following hepatic resection. Serum lactate concentration was recorded at the end of liver resection in a consecutive series of 488 patients over a seven-year period. Liver function, coagulation and electrolyte tests were performed post-operatively. Renal dysfunction was defined as a creatinine rise of |1.5x the pre-operative value. The median lactate was 2.8 mmol/L (0.6 to 16 mmol/L) and was elevated (≥2 mmol/L) in 72% of patients. The lactate concentration was associated with peak post-operative bilirubin, prothrombin time, renal dysfunction, length of hospital stay and 90-day mortality (P | 0.001). The 90-day mortality in patients with a post-operative lactate ≥6 mmol/L was 28% compared to 0.7% in those with lactate ≤2 mmol/L. Pre-operative diabetes, number of segments resected, the surgeons assessment of liver parenchyma, blood
https://perioperativemedicinejournal.biomedcentral.com/articles/10.1186/2047-0525-2-21/tables/3
Stricture of common hepatic duct after right hepatic lobectomy treated by Longmires operation.
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
http://pubmedcentralcanada.ca/pmcc/articles/PMC1436788/
Curative Resection of Hepatocellualr Carcinoma Using Modified Glissonean Pedicle Transection versus the Pringle Maneuver: A...Curative Resection of Hepatocellualr Carcinoma Using Modified Glissonean Pedicle Transection versus the Pringle Maneuver: A...
The Glissonean pedicle transection method has been reported to shorten operation time, reduce intraoperative blood loss, and minimize surgical risks in HCC patients undergoing hepatectomy 22. The Glissonean approach may therefore be more beneficial for HCC patients undergoing curative resection than other hilar vascular control methods such as the Pringle maneuver. However, in a large series, only 17.1% of patients underwent major hepatectomy involving two or more segments, with most patients (80.3%) undergoing segmentectomy or subsegmentectomy18. Our patient cohort differs in the extent of liver resection as well as including only patients with large (, 5 cm) nodular HCCs. 56% Of the 25 patients in our Glissonean group, 14 (56%) underwent removal of more than 2.5 segments (right trisegmetectomy).. To our best knowledge, our study is the first to compare the surgical effectiveness and safety of Glissonean transection with the Pringle maneuver in patients with large HCC undergoing radical ...
http://www.medsci.org/v09p0843.htm
Blood purification for postoperative liver failure with special reference to chronic hepatic support for those awaiting liver...Blood purification for postoperative liver failure with special reference to chronic hepatic support for those awaiting liver...
Blood purification, mainly plasma exchange (PE), was carried out for 13 cases of acute, and two cases of chronic postoperative liver failure. Four of thirteen acute cases (31%) survived. Although only one of eight with chronic liver disease survived, three of five without chronic liver disease survived. In most of those who lived, other organ failure occurred less often; total bilirubin and blood ammonia were less than 15 mg/dl and 200 micrograms/dl, respectively, before PE: and total bilirubin, blood ammonia, and branched chain amino acid/aromatic amino acid (BCAA/AAA) ratios recovered after five or fewer sessions of PE. Two chronic cases, treated for 1 and 4 years, respectively, were good candidates for liver or multiple organ transplantation. Although both died, PE was effective in reducing jaundice and in improving consciousness and general condition. Plasma exchange should be introduced early after assessing the changes in total bilirubin, blood ammonia, and coma grade in patients with acute
https://www.semanticscholar.org/paper/Blood-purification-for-postoperative-liver-failure-Omokawa-Asanuma/06935025184172c4eb38e5fee3068753a2681284
JCI - Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomyJCI - Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy
Stem cell factor (SCF) is a molecule with known proliferative effects on hematopoietic cells. More recent studies suggest that this molecule may also have effects on cellular differentiation and proliferation in other types of cells. The current investigations demonstrate that there is a large reservoir of SCF in the liver, that hepatic SCF levels change dramatically following partial hepatectomy in mice, and that SCF blockade, either by administration of anti-SCF antibodies or by using genetically altered, SCF-deficient mice, inhibits hepatocyte proliferation after partial hepatectomy; if SCF is replaced in the genetically SCF-deficient mice after partial hepatectomy, hepatocyte proliferation is restored to that seen in WT animals. Furthermore, SCF administration to IL-6 knockout mice also restores hepatocyte proliferation to normal. In vitro studies using primary mouse hepatocytes demonstrate that SCF causes hepatocyte proliferation and is induced by IL-6 and that treatment with anti-SCF ...
https://www.jci.org/articles/view/17391/figure/1
BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality - Semantic...BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality - Semantic...
A delay in liver regeneration after partial hepatectomy (PHx) leads to acute liver injury, and such delays are frequently observed in aged patients. BubR1 (budding uninhibited by benzimidazole-related 1) controls chromosome mitotic segregation through the spindle assembly checkpoint, and BubR1 down-regulation promotes aging-associated phenotypes. In this study we investigated the effects of BubR1 insufficiency on liver regeneration in mice. Low-BubR1-expressing mutant (BubR1(L/L)) mice had a delayed recovery of the liver weight-to-body weight ratio and increased liver deviation enzyme levels after PHx. Microscopic observation of BubR1(L/L) mouse liver showed an increased number of necrotic hepatocytes and intercalated disc anomalies, resulting in widened inter-hepatocyte and perisinusoidal spaces, smaller hepatocytes and early-stage microvilli atrophy. Up-regulation of desmocollin-1 (DSC1) was observed in wild-type, but not BubR1(L/L), mice after PHx. In addition, knockdown of BubR1 expression caused
https://www.semanticscholar.org/paper/BubR1-Insufficiency-Impairs-Liver-Regeneration-in-Ikawa-Yoshida-Matsumoto/b172f1d698eeddf448071eaed4f9564ea617ebb6
Safety and efficacy of preoperative right portal vein embolization in patients at risk for postoperative liver failure...Safety and efficacy of preoperative right portal vein embolization in patients at risk for postoperative liver failure...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1477-2574.2011.00402.x/pdf
Most recent papers with the keyword Single port surgery | Read by QxMDMost recent papers with the keyword Single port surgery | Read by QxMD
It remains unclear if single incision laparoscopic liver surgery is superior to standard multiport resections and in what regard patients might benefit from this approach. We retrospectively analyzed the course of all patients undergoing laparoscopic left lateral sectionectomy at our center between 2009 and 2017. In total, 11 single incision and 31 multiport left lateral sectionectomies were performed at our center between July 2009 and May 2017. Six patients were excluded due to multivisceral resections. Indications included adenoma (n = 7 vs n = 2), focal nodular hyperplasia (n = 4 vs n = 3), hepatocellular carcinoma (n = 4 vs n = 4), colorectal liver metastasis (n = 4 vs n = 0), noncolorectal metastasis (n = 2 vs n = 1), hemangioma (n = 3 vs n = 0), abscess (n = 1 vs n = 0), and cysts (n = 1 vs n = 0 ...
https://www.readbyqxmd.com/keyword/9477
Hemodynamic Changes during Hepatic Vascular Exclusion: Use of Intraoperative Transesophageal Echocardiography a Case SeriesHemodynamic Changes during Hepatic Vascular Exclusion: Use of Intraoperative Transesophageal Echocardiography a Case Series
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
https://www.hindawi.com/journals/isrn/2011/278545/abs/
International Liver Transplantation Society » Education » Robotic Left Hepatectomy for HCC on CirrhosisInternational Liver Transplantation Society » Education » Robotic Left Hepatectomy for HCC on Cirrhosis
Authors:. Fabrizio Di Benedetto MD PhD FACS, Paolo Magistri MD. Hepato-pancreato-biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy. Summary:. This is the case of a 67 years-old man affected by chronic HBV-related liver cirrhosis who was diagnosed with a large hepatocellular carcinoma (HCC) of the left lobe, AFP negative. On CT-scan the lesion was suspect for diaphragmatic infiltration and resulted to be close to the left portal vein. After multidisciplinary evaluation in our Institutional tumor board the patient was scheduled for left hepatectomy with robotic approach. On exploratory laparoscopy there was no diaphragmatic infiltration, therefore the procedure was carried on as planned.. Robotic approach for HCC on cirrhosis is particularly effective to reduce the risk of liver decompensation and improve post-operative outcomes, with lesser incidence of morbidity, shorter in-hospital stay and early return to daily life activity. Moreover, ...
https://ilts.org/education/videos/robotic-left-hepatectomy-for-hcc-on-cirrhosis/
Omega-3 polyunsaturated fatty acids promote liver regeneration after 90% hepatectomy in rats.
To evaluate the effectiveness of omega-3 polyunsaturated fatty acid (ω-3 PUFA) administration on liver regeneration after 90% partial hepatectomy (PH) in rats. ω-3 PUFAs were intravenously injected in the ω-3 PUFA group before PH surgery. PH
http://www.biomedsearch.com/nih/Omega-3-polyunsaturated-fatty-acids/22783054.html
Commentary on Yan et al. Laparoscopic Liver Resection: A Review of Current Status<...
TY - JOUR. T1 - Commentary on Yan et al.. T2 - Laparoscopic Liver Resection: A Review of Current Status. AU - Gruttadauria, Salvatore. PY - 2017/5/1. Y1 - 2017/5/1. UR - http://www.scopus.com/inward/record.url?scp=85019109983&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85019109983&partnerID=8YFLogxK. U2 - 10.1089/lap.2017.29017.sg. DO - 10.1089/lap.2017.29017.sg. M3 - Comment/debate. AN - SCOPUS:85019109983. VL - 27. SP - 487. EP - 488. JO - Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A. JF - Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A. SN - 1092-6429. IS - 5. ER - ...
https://moh-it.pure.elsevier.com/en/publications/commentary-on-yan-et-al-laparoscopic-liver-resection-a-review-of-
MAJOR LIVER RESECTION FOR HILAR CHOLANGIOCARCINOMA - UCL DiscoveryMAJOR LIVER RESECTION FOR HILAR CHOLANGIOCARCINOMA - UCL Discovery
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
http://discovery.ucl.ac.uk/1313598/
Endothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat | ScienceEndothelial Cell-Derived Angiopoietin-2 Controls Liver Regeneration as a Spatiotemporal Rheostat | Science
Liver regeneration requires spatially and temporally precisely coordinated proliferation of the two major hepatic cell populations, hepatocytes and liver sinusoidal endothelial cells (LSECs), to reconstitute liver structure and function. The underlying mechanisms of this complex molecular cross-talk remain elusive. Here, we show that the expression of Angiopoietin-2 (Ang2) in LSECs is dynamically regulated after partial hepatectomy. During the early inductive phase of liver regeneration, Ang2 down-regulation leads to reduced LSEC transforming growth factor-β1 production, enabling hepatocyte proliferation by releasing an angiocrine proliferative brake. During the later angiogenic phase of liver regeneration, recovery of endothelial Ang2 expression enables regenerative angiogenesis by controlling LSEC vascular endothelial growth factor receptor 2 expression. The data establish LSECs as a dynamic rheostat of liver regeneration, spatiotemporally orchestrating hepatocyte and LSEC proliferation ...
https://science.sciencemag.org/content/343/6169/416.abstract?ijkey=QFigd%3EgL/%3E.XRow&keytype=ref&siteid=sci
Extended Thromboprophylaxis Safe, Effective After Liver Surgery | Physicians Weekly for Medical News, Journals & ArticlesExtended Thromboprophylaxis Safe, Effective After Liver Surgery | Physicians Weekly for Medical News, Journals & Articles
TUESDAY, Sept. 19, 2017 (HealthDay News) - For patients undergoing liver surgery, extended pharmacologic thromboprophylaxis appears effective and safe, according to a study published online Aug. 28 in the Journal of Thrombosis and Haemostasis.. Bradford J. Kim, M.D., M.H.S., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues examined the safety and efficacy of extended pharmacologic thromboprophylaxis in liver surgery for prevention of venous thromboembolism (VTE). A total of 124 patients who underwent liver resection for malignancy were placed on an extended pharmacologic thromboprophylaxis protocol. After discharge from the hospital, 91.1 percent of patients continued anticoagulant thromboprophylaxis to complete a course of 14 days after minor/minimally invasive hepatectomy or 28 days after major hepatectomy or VTE history.. The researchers found that the rates of intraoperative, postoperative, and overall transfusion were 5.6, 8.1, and 10.5 percent, ...
https://www.physiciansweekly.com/extended-thromboprophylaxis-safe-effective-after-liver-surgery/
Medical Tourism In India
Liver cancer can be treated in a number of different ways. Some of the commonly used methods by which this ailment can be treated is liver resection which involves surgically removing that part of the liver which contains tumor; laparoscopic resection in which as compared to liver resection involves carrying out three to four incisions into the liver in order to remove the tumor present part of the liver. This is relatively a less complicated surgery to perform. Apart from these two, there are some additional different forms of treatments like Partial Hepatectomy in which that part of the liver is removed which contains tumor and the last one being, liver transplant, which is medically also known as Total Hepatectomy in which the liver is completely removed and replaced with another. On an average, cost of liver cancer surgery in India for resection costs somewhere around twenty thousand rupees approximately while for liver transplant it is slightly on the higher side. ...
https://indiahealthhelpblog.blogspot.com/
Hepatic resection for isolated breast cancer liver metastasis: A single-center experienceHepatic resection for isolated breast cancer liver metastasis: A single-center experience
Although variable prognostic factors (patient age, number and size of metastases, lymph node infiltration, stage of primary disease, prior local recurrence of the primary tumor, and clear resection margin of metastatic lesion) have been suggested in some reports, many authors describe the importance of hormone receptor status as a prognostic factor for the primary tumor after complete resection of BCLM [12,17,20]. Golse and Adam [23] suggested that the best results after the resection of BCLM are achieved after applying selection criteria based on small metastases (, 4-5 cm), minor hepatectomy, radical resection (ideally R0, or R1), stable disease after neoadjuvant therapy, and a delay between primary and secondary lesions longer than 1 or 2 years. Howerver, the age of the patient, her hormone receptor status, and HER2 overexpression are not strong predictors of overall survival [23]. In our study, time to recurrence was relatively short if the metastatic lesion was larger than 5 cm, or there ...
http://www.kjco.org/journal/view.php?number=283
Clinical Feasibility of Inferior Right Hepatic Vein-Preserving Trisegmentectomy 5, 7, and 8 (with Video) | SpringerLinkClinical Feasibility of Inferior Right Hepatic Vein-Preserving Trisegmentectomy 5, 7, and 8 (with Video) | SpringerLink
Background and Aim Hepatic resection involves not only complete removal of tumors but also preservation of optimal liver function after surgery. This study introduces the technique of inferior right...
https://link.springer.com/article/10.1007%2Fs11605-012-2130-0
Plus itPlus it
When rats were subjected to partial hepatectomy, glucosamine 6-phosphate synthase (EC 5.3.1.19) of the remaining liver underwent alterations both in activity and in molecular form. To study the molecular alterations, glucosamine 6-phosphate synthase was purified from regenerating as well as control liver and was analyzed by isoelectric focusing. Although control liver exhibited only one form of glucosamine 6-phosphate synthase with a pl of 5.0, sequential and transient appearance of three other forms, with pl values of 4.3, 4.8, and 4.5, respectively, was observed for regenerating liver within 72 hr following partial hepatectomy. Laparotomy, on the other hand, induced in the liver only the pl 4.8 form, and injection of a mixture containing triiodothyronine, amino acids, glucagon, and heparin induced only the pl 4.3 and 4.5 forms. It therefore appears that the pl 4.3 and 4.5 forms, but not the pl 4.8 form, are associated with hepatic DNA synthesis. The pl 4.8 form is induced in the liver in ...
http://cancerres.aacrjournals.org/content/39/7_Part_1/2783
RePub, Erasmus University Repository: Ferumoxide-enhanced magnetic resonance imaging techniques in pre-operative assessment...RePub, Erasmus University Repository: Ferumoxide-enhanced magnetic resonance imaging techniques in pre-operative assessment...
Aim: The objective was to evaluate whether contrast-enhanced magnetic resonance imaging (MRI) techniques used in a pre-operative assessment protocol for colorectal liver metastases are as accurate as spiral computer tomography during arterial portography (CTAP). Pre-operative accuracy and clinical consequences of MRI are described and compared with CTAP. Moreover, post-operative survival rate and tumour recurrence were studied. Methods: The study group comprised 84 patients which were possible candidates for a partial hepatectomy for colorectal liver metastases. Patients were pre-operatively evaluated by CT of the abdomen, CT of the thorax and spiral CTAP and ferumoxide-enhanced MRI was performed in routine way for all patients. Following this selection, 35 patients underwent a partial hepatectomy with curative intent. All patients were retrospectively evaluated. Results: Ferumoxide-enhanced MRI proved to be at least as accurate as spiral CTAP in 81% of patients. In nine patients (11%) spiral ...
https://repub.eur.nl/pub/64588
Effect of nurse-to-patient ratio in the intensive care unit on pulmonary complications and resource use after hepatectomy |...Effect of nurse-to-patient ratio in the intensive care unit on pulmonary complications and resource use after hepatectomy |...
BACKGROUND: Nurse-to-patient ratios in the intensive care unit are associated with postoperative mortality, morbidity, and costs after some high-risk surgery. OBJECTIVE: To determine if having 1 nurse caring for 1 or 2 patients (more nurses) versus 1 nurse caring for 3 or more patients (fewer nurses) in the intensive care unit at night is associated with differences in clinical and economic outcomes after hepatectomy. METHODS: Statewide observational cohort study of 569 adults who had hepatic resection, 1994 to 1998. Hospital discharge data were linked to a prospective survey of organizational characteristics in the intensive care unit. Multivariate analysis was used to determine the association of nighttime nurse-to-patient ratios with in-hospital mortality, length of stay, hospital costs, and specific postoperative complications. RESULTS: A total of 240 patients at 25 hospitals had fewer nurses; 316 patients in 8 hospitals had more nurses. No significant association between nighttime ...
https://aacnjournals.org/ajcconline/article-abstract/10/6/376/4590/Effect-of-nursetopatient-ratio-in-the-intensive
Influence of two different resection techniques (conventional liver resection versus anterior approach) of liver metastases...Influence of two different resection techniques (conventional liver resection versus anterior approach) of liver metastases...
Despite the use of alternative therapy strategies surgical resection of colorectal liver metastases remains the treatment of choice and is associated with long-term survival in a significant number of patients [1, 2]. After curative resection of colorectal liver metastases the 5-year survival rate ranges from 20% to 51% depending on preoperative selection criteria and published series [3]. However, up to 75% of resected patients will develop extra- or intrahepatic tumor recurrence [4]. One possible cause for this tumor recurrence may be intraoperative hematogenous tumor cell dissemination due to mechanical manipulation of the tumor during hepatic resection [5].. Recently, RT-PCR based protocols were developed for the detection of disseminated tumor cells [6]. We developed a sensitive and specific CK 20 RT-PCR system for detection of disseminated colorectal cancer cells in blood, bone marrow and lymph nodes [7-9]. By using the CK 20 RT-PCR, we demonstrated that there is a significantly enhanced ...
https://bmcsurg.biomedcentral.com/articles/10.1186/1471-2482-8-6
Hepatoprotective effects of glycine and vitamin E, during the early phase of liver regeneration in the ratHepatoprotective effects of glycine and vitamin E, during the early phase of liver regeneration in the rat
Our objective was to demonstrate the protective effect of glycine (Gly) and vitamin E (VE) on a model ofethanol-induced acute liver injury during the early phase of liver regeneration after partial hepatectomy(PH) in rats. Fifty male Wistar rats (body weight (b.w.), 240 - 280 g) were divided into four groups (n = 10,each, respectively) as follows: 1) control partial hepatectomy (PH), 70%; 2) PH + ethanol (EtOH) at 1.5g/kg b.w; 3) PH + Gly (0.6 g/kg b.w) + EtOH, and; 4) PH + VE (400 International units [IU]) + EtOH. Twentyfour h after surgery, animals were killed and liver damage and oxidative stress parameters weremeasured. Ethanol caused a decrease in serum albumin (2.27 vs 3.12 g/dL; p < 0.05), cholesterol (31.4vs 48.0 mg/dL; p < 0.05), Aspartate aminotransferase (AST, 70 vs 380 UI; p < 0.05), and alanineaminotransferase (ALT, 110 vs 170 UI; p < 0.05) in comparison with the PH control group, but thesedecreases were reverted with either Gly or VE administration. Furthermore, Gly and VE ...
https://www.uaeh.edu.mx/investigacion/productos/2083/
Potential utility of xenobiotic mitogens in the context of liver regeneration in the elderly and living-related transplantation...Potential utility of xenobiotic mitogens in the context of liver regeneration in the elderly and living-related transplantation...
Although liver regeneration occurring after partial hepatectomy (PH) is greatly reduced in aged mice, liver hyperplasia induced by xenobiotic mitogens was found to be age independent. Here, we investigated the potential utility of mitogens in stimulating liver regeneration in old mice subjected to two-third PH. Although virtually no hepatocytes entered S phase 48 h after PH, pretreatment (2 h prior to surgery) with 1,4-bis(2-(3,5-dichloropyridyloxy)benzene (TCPOBOP), a ligand of constitutive androstane receptor, induced an increase of bromodeoxyuridine incorporation and enhanced the expression of cyclin D1, cyclin A and proliferating cell nuclear antigen . Next, we investigated the potential utility of mitogens in the context of donor conditioning prior to living-related transplantation. Three days after TCPOBOP administration to intact young mice, an almost doubling of the liver mass and DNA content occurred; the regenerative response to two-third resection of the TCPOBOP-induced hyperplastic ...
https://iris.unica.it/handle/11584/109322
JCI - Gadd45β promotes hepatocyte survival during liver regeneration in mice by modulating JNK signalingJCI - Gadd45β promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling
In the liver, the JNK cascade is induced downstream of TNF receptors (TNFRs) in response to inflammatory, microbial, and toxic challenges. Sustained activation of JNK triggers programmed cell death (PCD), and hepatocyte survival during these challenges requires induction of the NF-κB pathway, which antagonizes this activation by upregulating target genes. Thus, modulation of JNK activity is crucial to the liver response to TNFR-mediated challenge. The basis for this modulation, however, is unknown. Here, we investigated the role of the NF-κB target Gadd45b in the regulation of hepatocyte fate during liver regeneration after partial hepatectomy. We generated Gadd45b-/- mice and found that they exhibited decreased hepatocyte proliferation and increased PCD during liver regeneration. Notably, JNK activity was markedly increased and sustained in livers of Gadd45b-/- mice compared with control animals after partial hepatectomy. Furthermore, imposition of a Jnk2-null mutation, attenuating JNK ...
https://www.jci.org/articles/view/33913/figure/1
Long-term survival and disease recurrence following portal vein embolisation prior to major hepatectomy for colorectal...Long-term survival and disease recurrence following portal vein embolisation prior to major hepatectomy for colorectal...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/19130138
Comparison of Hemostatic Oppel and Cold Plasma Device for Partial Hepatectomy | SciTechnolComparison of Hemostatic Oppel and Cold Plasma Device for Partial Hepatectomy | SciTechnol
Purpose: The main difficulty with liver surgery is blood loss. It is hard in this case to achieve hemostasis because of the oozing bleeding. The aim of this study was to ..
https://www.scitechnol.com/peer-review/comparison-of-hemostatic-oppel-and-cold-plasma-device-for-partial-hepatectomy-xJdK.php?article_id=8313
Robotic versus laparoscopic liver resection: a comparative study from a single center | SpringerLinkRobotic versus laparoscopic liver resection: a comparative study from a single center | SpringerLink
Purpose The significant advantages of robotic surgery have expanded the scope of surgical procedures that can be performed through minimally invasive techniques. The aim of this study was to compare...
https://link.springer.com/article/10.1007%2Fs00423-014-1238-y
Second Surgery to Remove Cancer Spread to Liver May Improve Colorectal Cancer SurvivalSecond Surgery to Remove Cancer Spread to Liver May Improve Colorectal Cancer Survival
According to results recently published in the Archives of Surgery, a second surgery to remove colorectal cancer that has spread to the liver can significantly improve survival.. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. The liver is one of the most common places to which colorectal cancer spreads in its advanced stages. Cancer spread to the liver is referred to as liver metastasis.. Treatment for liver metastasis depends upon overall health of the patient, extent of spread, and anatomical location of the metastasis. Overall, surgical removal of cancer in the liver (hepatic resection) appears to provide the best outcomes. Surgeons often remove a part of the liver (hepatectomy) as well as the cancer. However, because outcomes following a second hepatic resection have not been clearly established, patients often undergo just one resection.. Researchers from France recently conducted a study to evaluate data including 40 patients with colorectal ...
http://cancer.unm.edu/2009/03/08/second-surgery-to-remove-cancer-spread-to-liver-may-improve-colorectal-cancer-survival/
Stem Cells in Liver Regeneration: Fusion or Plasticity - Bryon PetersenStem Cells in Liver Regeneration: Fusion or Plasticity - Bryon Petersen
The liver has an enormous capacity to regenerate, as demonstrated by the 2/3 partial hepatectomy model in rodents. In addition, the liver has a stem cell compar...
http://grantome.com/grant/NIH/R01-DK065096-08
A review of paediatric liver resections in Johannesburg: experiences and preferred techniqueA review of paediatric liver resections in Johannesburg: experiences and preferred technique
Discussion. The regenerative capacity of the liver was first described in ancient times, and dates back to Greek mythology:1 Prometheus, a titan and champion of mankind, stole fire from Zeus and presented it to humans. As punishment, Zeus sentenced Prometheus to eternal torment. He was incarcerated on a rock and each day an eagle was sent to feed on his swliver. Fortunately (or unfortunately!) the liver regenerated each night and the eagle returned daily, sentencing Prometheus to eternal torment.. Thankfully, the regenerative capacity of the liver forms the basis of modern hepatobiliary surgery, where in the presence of a noncirrhotic liver, up to 80% of the liver can safely be resected, relying on this regenerative capacity of the remnant to sustain the patients functional requirements.1 Liver resection progress has been significant in the last few decades and pivotal to a better understanding of liver anatomy and physiology.2. Glisson gave the first accurate insights into liver anatomy in ...
http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742012001100027&lng=en&nrm=iso&tlng=en
HepatectomyHepatectomy
Hepatectomies may be anatomic, i.e. the lines of resection match the limits of one or more functional segments of the liver as ... Hepatectomy is the surgical resection (removal of all or part) of the liver. While the term is often employed for the removal ... The first hepatectomies were reported by Dr. Ichio Honjo (1913-1987) of (Kyoto University) in 1949, and Dr. Jean-Louis Lortat- ... Hepatectomy may also be the procedure of choice to treat intrahepatic gallstones or parasitic cysts of the liver. Partial ...
https://en.wikipedia.org/wiki/Hepatectomy
Guido TorzilliGuido Torzilli
"Upper Transversal Hepatectomy". Annals of Surgical Oncology. 19 (11): 3566-3566. doi:10.1245/s10434-012-2596-8. ISSN 1068-9265 ...
https://en.wikipedia.org/wiki/Guido_Torzilli
Radiation lobectomyRadiation lobectomy
Garcea, G.; Ong, S.L.; Maddern, G.J. (2009). "Predicting liver failure following major hepatectomy". Digestive and Liver ...
https://en.wikipedia.org/wiki/Radiation_lobectomy
Jean EmondJean Emond
One-year morbidity after donor right hepatectomy. Rudow DL, Brown RS Jr, Emond JC, Marratta D, Bellemare S, Kinkhabwala M. ...
https://en.wikipedia.org/wiki/Jean_Emond
David GellerDavid Geller
Laparoscopic major hepatectomy: an evolution in standard care. Ann. Surg. 2009; 250:856-860. Nyugen KT, Steel J, Vanounou T, ...
https://en.wikipedia.org/wiki/David_Geller
List of -ectomiesList of -ectomies
Hepatectomy is the surgical resection of the liver. Hypophysectomy is the surgical removal of the pituitary gland or hypophysis ...
https://en.wikipedia.org/wiki/List_of_-ectomies
Liver regenerationLiver regeneration
The following describes regeneration following a partial hepatectomy. Following partial hepatectomy, regeneration occurs in ... There are two types of damage from which the liver is able to regenerate, one being a partial hepatectomy and the other being ... This priming phase occurs within 5 hours of the hepatectomy and deals mainly with events prior to entering the cell cycle and ... The final phase is termination of proliferation by TGF-β (transforming growth factor beta). Immediately after a hepatectomy, ...
https://en.wikipedia.org/wiki/Liver_regeneration
Ursolic acidUrsolic acid
... enhances mouse liver regeneration after partial hepatectomy. Ursolic acid enhances the cellular immune system and ... "Ursolic acid enhances mouse liver regeneration after partial hepatectomy". Pharmaceutical Biology. 50 (4): 523-528. doi:10.3109 ...
https://en.wikipedia.org/wiki/Ursolic_acid
Cantlie lineCantlie line
It is useful for performing hepatectomies. The division divides the liver into two planes. It extends from the middle hepatic ... Cantlie's line is useful when performing hepatectomies. It was first described by Scottish surgeon James Cantlie in 1887 when ...
https://en.wikipedia.org/wiki/Cantlie_line
Recurrent pyogenic cholangitisRecurrent pyogenic cholangitis
With resistant infection, a surgical hepatectomy or hepaticocutaneousjejunostomy can be performed. Lifelong surveillance for ...
https://en.wikipedia.org/wiki/Recurrent_pyogenic_cholangitis
Claude CouinaudClaude Couinaud
These anatomic facts permitted the development of hepatectomies. His book Le Foie: Études anatomiques et chirurgicales stands ...
https://en.wikipedia.org/wiki/Claude_Couinaud
LaparoscopyLaparoscopy
Li H, Zheng J, Cai JY, Li SH, Zhang JB, Wang XM, Chen GH, Yang Y, Wang GS (November 2017). "VS open hepatectomy for ...
https://en.wikipedia.org/wiki/Laparoscopy
SLC25A29SLC25A29
"A Novel Mitochondrial Carnitine-acylcarnitine Translocase Induced by Partial Hepatectomy and Fasting". Journal of Biological ...
https://en.wikipedia.org/wiki/SLC25A29
MiR-122MiR-122
... has also been suggested as a biomarker for hepatectomy-induced liver injury in patients with hepatocellular carcinoma. ... "Correlation between plasma miR-122 expression and liver injury induced by hepatectomy". The Journal of International Medical ...
https://en.wikipedia.org/wiki/MiR-122
Pringle manoeuvrePringle manoeuvre
Right Hepatectomy", Surgical Pitfalls, Philadelphia: W.B. Saunders, pp. 329-338, ISBN 978-1-4160-2951-9, retrieved 2021-01-25 ... "Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized study". Annals of Surgery. 226 (6): ... "Tolerance of the liver to intermittent pringle maneuver in hepatectomy for liver tumors". Archives of Surgery. 134 (5): 533-9. ... "Tolerance of the Liver to Intermittent Pringle Maneuver in Hepatectomy for Liver Tumors". Archives of Surgery. 134 (5): 533-539 ...
https://en.wikipedia.org/wiki/Pringle_manoeuvre
Capillaria hepaticaCapillaria hepatica
Santos, CC; Onofre-Nunes, Z; Andrade, ZA (2007). "Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis ...
https://en.wikipedia.org/wiki/Capillaria_hepatica
Theodor Bilharz Research InstituteTheodor Bilharz Research Institute
Studies on partial hepatectomy, liver regeneration and transplantation are items of this program. Innovation in Applied Medical ...
https://en.wikipedia.org/wiki/Theodor_Bilharz_Research_Institute
Natesan RangabashyamNatesan Rangabashyam
He introduced Vagotomy and was known to have performed his first Hepatectomy there. He stayed in Thanjavur for 5 years and ...
https://en.wikipedia.org/wiki/Natesan_Rangabashyam
Steven Clark CunninghamSteven Clark Cunningham
Hepatectomy Pancreatectomy Children's poetry "Specialist in pancreatic and liver surgery joins St. Agnes Hospital". The ...
https://en.wikipedia.org/wiki/Steven_Clark_Cunningham
Portal vein embolizationPortal vein embolization
... however now there may be a role of PVE in combination with a two-stage hepatectomy. Additionally, patients who have an ... "Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome". British Journal ...
https://en.wikipedia.org/wiki/Portal_vein_embolization
Sida cordifoliaSida cordifolia
"Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy". Acta Cirurgica Brasileira. ...
https://en.wikipedia.org/wiki/Sida_cordifolia
HemangioendotheliomaHemangioendothelioma
Surgical resection, partial hepatectomy, and embolization of afferent vessels should be considered for severe cases. Low power ...
https://en.wikipedia.org/wiki/Hemangioendothelioma
Surgical Outcomes Analysis and ResearchSurgical Outcomes Analysis and Research
"Comparison of Right Lobe Donor Hepatectomy with Elective Right Hepatectomy for Other Causes in New York". Dig Dis Sci. 56 (6): ... "Comparison of Right Lobe Donor Hepatectomy with Elective Right Hepatectomy for Other Casuses in New york". Dig Dis Sci. 56 (6 ...
https://en.wikipedia.org/wiki/Surgical_Outcomes_Analysis_and_Research
LiMAx testLiMAx test
Prediction of postoperative outcome after hepatectomy with a new bedside test for maximal liver function capacity. Annals of ... Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and ...
https://en.wikipedia.org/wiki/LiMAx_test
Randy JirtleRandy Jirtle
PMID 6692410 Jirtle RL, Michalopoulos G (1982), "Effects of partial hepatectomy on transplanted hepatocytes", Cancer Res. 42: ...
https://en.wikipedia.org/wiki/Randy_Jirtle
Hepatocellular carcinomaHepatocellular carcinoma
This may be accomplished by resection the affected portion of the liver (partial hepatectomy) or in some cases by orthotopic ... which may qualify the patient for a partial hepatectomy. Embolization is performed by an interventional radiologist using a ... transplantation is not associated with improved survival compared to hepatectomy, but instead is significantly more expensive. ... "A Prospective Randomized Trial Comparing Percutaneous Local Ablative Therapy and Partial Hepatectomy for Small Hepatocellular ...
https://en.wikipedia.org/wiki/Hepatocellular_carcinoma
Fikri AlicanFikri Alican
Alican, Fikri; Çayırlı, Mukadder; Keith, Virginia (March 1971). "One-Stage Hepatectomy in the Dog with Restoration of the Vena ... Replantation of the Liver in Dogs Following Total Hepatectomy]". Türk Tıp Cemiyeti Mecmuası. 33 (4): 209-226. ISSN 0494-2736. ...
https://en.wikipedia.org/wiki/Fikri_Alican
Perioperative mortalityPerioperative mortality
July 2011). "Refining the definition of perioperative mortality following hepatectomy using death within 90 days as the ...
https://en.wikipedia.org/wiki/Perioperative_mortality
Sodium-coupled neutral amino acid transporter 2Sodium-coupled neutral amino acid transporter 2
2002). "ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane". ...
https://en.wikipedia.org/wiki/Sodium-coupled_neutral_amino_acid_transporter_2
CholangiocarcinomaCholangiocarcinoma
... are usually treated with partial hepatectomy. Various series have reported survival estimates after surgery ranging from 22 to ...
https://en.wikipedia.org/wiki/Cholangiocarcinoma
Medical Science Monitor | Selective Hemihepatic Vascular Occlusion Versus Pringle Maneuver in Hepatectomy for Primary Liver...Medical Science Monitor | Selective Hemihepatic Vascular Occlusion Versus Pringle Maneuver in Hepatectomy for Primary Liver...
MATERIAL AND METHODS:A total of 63 patients with primary hepatocellular carcinoma who underwent hepatectomy during June 2006 ... During hepatectomy, selective hemihepatic vascular occlusion benefits the patients with primary hepatocellular carcinoma by ... and 37 patients in group B underwent the Pringle maneuver during hepatectomy. The intraoperative conditions, postoperative ... This study was conducted to compare the clinical effects of two techniques used for inflow occlusion during hepatectomy ( ...
https://medscimonit.com/abstract/related/idArt/900859
British Library EThOS: Post hepatectomy liver failure : risk factors and prediction of post-operative function using novel...British Library EThOS: Post hepatectomy liver failure : risk factors and prediction of post-operative function using novel...
Post hepatectomy liver failure : risk factors and prediction of post-operative function using novel dynamic MRI ... there remains a significant risk of developing Post-Hepatectomy Liver Failure (PHLF) - caused by inadequate remnant liver ...
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800492
Development and validation of a nomogram for assessing survival in patients with hepatocellular carcinoma after hepatectomy |...Development and validation of a nomogram for assessing survival in patients with hepatocellular carcinoma after hepatectomy |...
Development and validation of a nomogram for assessing survival in patients with hepatocellular carcinoma after hepatectomy ... All patients had been traced from the day of hepatectomy to August 31, 2018, until the patient dies or lost to follow-up. Most ... Survival time was defined as the interval (in months) from the date of hepatectomy to the date of last follow-up (August 31, ... First, in this training cohort, hepatectomy resulted in the death of 21.0% at 1 year, 39.3% at 3 years, and 50.5% at 5 years. ...
https://portlandpress.com/bioscirep/article/40/6/BSR20192690/225100/Development-and-validation-of-a-nomogram-for
Hepatectomy for liver metastasis from rectal cancer in a patient with mitochondrial disease | BMJ Case ReportsHepatectomy for liver metastasis from rectal cancer in a patient with mitochondrial disease | BMJ Case Reports
Hepatectomy for liver metastasis from rectal cancer in a patient with mitochondrial disease ... Hepatectomy for liver metastasis from rectal cancer in a patient with mitochondrial disease ...
https://casereports.bmj.com/content/14/2/e238653.alerts
Survival analysis of sorafenib in hepatocellular carcinoma patients with microvascular invasion after hepatectomy | OncologyPROSurvival analysis of sorafenib in hepatocellular carcinoma patients with microvascular invasion after hepatectomy | OncologyPRO
The aim of the study was to analyze the effect of sorafenib on the clinical outcomes in HCC patients with MVI after hepatectomy ... Patients with HCC who underwent hepatectomy and were pathologically diagnosed as MVI at the research center between January ... Follow-up was performed after hepatectomy. The recurrence-free survival (RFS) and overall survival (OS) were observed. ... The recurrence rate after hepatectomy remains high, which seriously affects the prognosis. Microvascular invasion (MVI) has ...
https://oncologypro.esmo.org/meeting-resources/esmo-2018-congress/survival-analysis-of-sorafenib-in-hepatocellular-carcinoma-patients-with-microvascular-invasion-after-hepatectomy?page=4
Serval - A successful case of right hepatectomy in a patient with von Willebrand disease.Serval - A successful case of right hepatectomy in a patient with von Willebrand disease.
A successful case of right hepatectomy in a patient with von Willebrand disease. ...
https://serval.unil.ch/fr/notice/serval:BIB_BD54713F0CA1
Totally robotic right hepatectomy: surgical technique and outcomes | Archive ouverte UNIGE Totally robotic right hepatectomy: surgical technique and outcomes | Archive ouverte UNIGE
Robotic surgery for performance of right hepatectomy is safe and effective. Keywords Adult - Aged - Aged, 80 and over - Chronic ... GIULIANOTTI, Pier Cristoforo et al. Totally robotic right hepatectomy: surgical technique and outcomes. In: Archives of surgery ... Disease - Feasibility Studies - Female - Follow-Up Studies - Hepatectomy/methods - Humans - Liver Diseases/surgery - Male - ...
https://archive-ouverte.unige.ch/unige:29935
Expression of glioma-associated oncogene 2 (Gli 2) is correlated with poor prognosis in patients with hepatocellular carcinoma...
Re-imagining discovery and access to research: grants, datasets, publications, citations, clinical trials, patents and policy documents in one place.
https://app.dimensions.ai/details/publication/pub.1036716771
Use of Serial Percutaneous Ethanol Injections and Partial Hepatectomy for the Successful Management of a Hepatocellular...Use of Serial Percutaneous Ethanol Injections and Partial Hepatectomy for the Successful Management of a Hepatocellular...
With adequate tumor necrosis, a partial hepatectomy was successfully performed by a liver-transplant specialist from University ... Use of Serial Percutaneous Ethanol Injections and Partial Hepatectomy for the Successful Management of a Hepatocellular ...
https://www.vin.com/apputil/content/defaultadv1.aspx?id=9979341&pid=26429&
Comprehensive economic evaluation of enhanced recovery after surgery in hepatectomy | International Journal for Equity in...Comprehensive economic evaluation of enhanced recovery after surgery in hepatectomy | International Journal for Equity in...
We aimed to assess the economic impact of ERAS in hepatectomy from the perspectives of patients, hospitals and society, as well ... Hepatectomy (the ICD − 10 disease code is D18.013) is a widely used operation with heavy burden, which causes long-term stress ... It is also considered one of the most effective disease scenarios for ERAS [15, 16]. Thus, we took hepatectomy as an example ... Dong, Y., Zhang, Y. & Jin, C. Comprehensive economic evaluation of enhanced recovery after surgery in hepatectomy. Int J Equity ...
https://equityhealthj.biomedcentral.com/articles/10.1186/s12939-021-01583-3
A simple dummy liver assist device prolongs anhepatic survival in a porcine model of total hepatectomy by slight hypothermia |...A simple dummy liver assist device prolongs anhepatic survival in a porcine model of total hepatectomy by slight hypothermia |...
Total hepatectomy was performed in ten female pigs followed by standardized intensive care support until death. Five animals ( ... 1345 ± 700 μg/dL) from 48 hours after hepatectomy until death. A significant rise of endotoxin levels indicated the onset of ... Body temperature 24 hours after hepatectomy was significantly lower (36.5 ± 0.5°C vs. 38.2 ± 0.7°C) in the dummy device group. ... sepsis at time of death in 60% (3/5) of the dummy device group animals surviving beyond 60 hours from hepatectomy. Episodes of ...
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-11-79
The effects of anesthetic regimen in 90% hepatectomy in rats - [scite report]The effects of anesthetic regimen in 90% hepatectomy in rats - [scite report]
Hepatectomy. Isoflurane. Ketamine. Xylazine. Ratos. RESUMO OBJETIVO:Avaliar a influência do regime anestésico sobre a ... The effects of anesthetic regimen in 90% hepatectomy in ratsActa Cirúrgica Brasileira -Vol. 27 (10) 2012 -703 A sobrevida em 72 ... partial hepatectomy in rats. METHODS:Thirty adult male Wistar rats were divided into two groups according to their anesthetic ... hepatectomy. CONCLUSION:Isoflurane anesthesia reduced the recovery time and incidence of hypoglycemia and increased the ...
https://scite.ai/reports/the-effects-of-anesthetic-regimen-8bredx
Intraoperative ultrasonographic detection of communicating veins between adjacent hepatic veins during hepatectomy for tumours...
No patient had a formal major hepatectomy. There was no postoperative mortality or major morbidity. Conclusion: EF-IOUS ... No patient had a formal major hepatectomy. There was no postoperative mortality or major morbidity. Conclusion: EF-IOUS ... No patient had a formal major hepatectomy. There was no postoperative mortality or major morbidity. Conclusion: EF-IOUS ... No patient had a formal major hepatectomy. There was no postoperative mortality or major morbidity. Conclusion: EF-IOUS ...
https://moh-it.pure.elsevier.com/en/publications/intraoperative-ultrasonographic-detection-of-communicating-veins-
"Are We Sure that Blood Transfusion is Associated with Recurrence of Hepatocellular Carcinoma After Hepatectomy?": Reply<...
"Are We Sure that Blood Transfusion is Associated with Recurrence of Hepatocellular Carcinoma After Hepatectomy?" : Reply. In: ... "Are We Sure that Blood Transfusion is Associated with Recurrence of Hepatocellular Carcinoma After Hepatectomy?" : Reply. / ... "Are We Sure that Blood Transfusion is Associated with Recurrence of Hepatocellular Carcinoma After Hepatectomy?": Reply. ... title = ""Are We Sure that Blood Transfusion is Associated with Recurrence of Hepatocellular Carcinoma After Hepatectomy?": ...
https://kyushu-u.pure.elsevier.com/en/publications/are-we-sure-that-blood-transfusion-is-associated-with-recurrence-
ALPPS vs. Two-Stage Hepatectomy RCT | ALPPSALPPS vs. Two-Stage Hepatectomy RCT | ALPPS
Associating Liver Partition with Portal vein ligation for Staged hepatectomy (ALPPS) versus Two-Stage Hepatectomy (TSH) for ...
http://alpps.net/?q=rct
Factors influencing survival of patients undergoing hepatectomy for colorectal metastases<...
Factors influencing survival of patients undergoing hepatectomy for colorectal metastases. J. Yamamoto, K. Shimada, T. Kosuge, ... Factors influencing survival of patients undergoing hepatectomy for colorectal metastases. In: British Journal of Surgery. 1999 ... The aim of this study was to clarify the significant prognostic factors after hepatectomy for colorectal metastases, with ... The aim of this study was to clarify the significant prognostic factors after hepatectomy for colorectal metastases, with ...
https://keio.pure.elsevier.com/en/publications/factors-influencing-survival-of-patients-undergoing-hepatectomy-f
Liver cancer: Causes, diagnosis, and treatmentLiver cancer: Causes, diagnosis, and treatment
Partial hepatectomy. When the tumor is small and occupies a limited section of the liver, a surgeon can remove this part of the ... Only people with otherwise healthy liver function are suitable for hepatectomy. Also, the procedure may not be a viable ... In this case, a surgeon needs to leave enough healthy tissue after hepatectomy for the liver to function. ...
https://www.medicalnewstoday.com/articles/172408?utm_source=ReadNext
Liver regeneration ofter partial hepatectomy. Function of the lipid messengers - Postępy Higieny i Medycyny Doświadczalnej -...
The lipid messengers may be potent factors affecting process of liver regeneration after partial hepatectomy. ...
http://psjd.icm.edu.pl/psjd/element/bwmeta1.element.element-from-psjc-39f2a853-5c8a-3b60-8de7-600928d98282?printView=true
Laparoscopic Living Donor Hepatectomy | SingHealthLaparoscopic Living Donor Hepatectomy | SingHealth
LAPAROSCOPIC LIVING DONOR HEPATECTOMY AT THE SINGHEALTH DUKE-NUS TRANSPLANT CENTRE. ​With an established living donor liver ... A laparoscopic donor hepatectomy offers the benefits of faster recovery, less pain and far superior cosmesis. Our donors stay ... Laparoscopic Living Donor Hepatectomy: Transforming the Liver Transplantation Landscape 2022-05-05T02:25:48.0000000Z SingHealth ... CHANGING THE LANDSCAPE OF LIVER DONATION WITH MINIMALLY INVASIVE HEPATECTOMY. Perhaps the most important advancement in liver ...
https://www.skh.com.sg/news/defining-med/laparoscopic-living-donor-hepatectomy
Management of POST-HEPATECTOMY complications | The SURGEONManagement of POST-HEPATECTOMY complications | The SURGEON
... complications after hepatectomy, digestive surgery, Hepatectomia, hepatectomy, ozimo gama ... Management of POST-HEPATECTOMY complications. por Ozimo Gama (PhD) em 6 de fevereiro de 2014. ... Since then, hepatectomy has been widely performed for the treatment of various liver diseases, such as malignant tumors, benign ... Common post-hepatectomy complications include venous catheter-related infection, pleural effusion, incisional infection, ...
https://thesurgeon.club/2014/02/06/management-of-post-hepatectomy-complications/
Surgical Resection in HCC | IntechOpenSurgical Resection in HCC | IntechOpen
5. Minimally invasive hepatectomy. 5.1. Laparoscopic-assisted partial hepatectomy. Although established as a safe and ... Gas embolism in laparoscopic hepatectomy: What is the optimal pneumoperitoneal pressure for laparoscopic major hepatectomy? ... Right hemi-hepatectomy consists of surgical resection of segments V-VIII and left hepatectomy includes segments II-IV and ... For open hepatectomy, the patient can be placed in slight reverse Trendelenburg position if pressures allow and switched to ...
https://www.intechopen.com/chapters/63803
Ovarian Cancer Treatment & Management: Approach Considerations, Choosing Appropriate Surgery, Surgical StagingOvarian Cancer Treatment & Management: Approach Considerations, Choosing Appropriate Surgery, Surgical Staging
Malignant lesions of the ovaries include primary lesions arising from normal structures within the ovary and secondary lesions from cancers arising elsewhere in the body. Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies), germ-cell tumors, sex-cord stromal tumors, and other more rare types.
https://www.medscape.com/answers/255771-194642/when-is-a-secondary-cytoreductive-surgery-indicated-in-the-treatment-of-ovarian-cancer
Medical Technical News, Research - Page 56Medical Technical News, Research - Page 56
Procoagulant-fibrinolytic balance may predict hepatectomy thrombosis An imbalance in procoagulant/fibrinolytic blood factors ...
https://www.news-medical.net/?tag=/Medical-Technical&page=56
Post-hepatectomy tolvaptan-induced hypernatremia in a hepatocellular carcinoma patient with cirrhosis: a case report | Surgical...Post-hepatectomy tolvaptan-induced hypernatremia in a hepatocellular carcinoma patient with cirrhosis: a case report | Surgical...
She was transferred to our hospital, and hepatectomy was performed in October 2019, after which pleural effusion and severe ... case report of a patient who developed hypernatremia after tolvaptan administration in the early stages following hepatectomy. ... From: Post-hepatectomy tolvaptan-induced hypernatremia in a hepatocellular carcinoma patient with cirrhosis: a case report ...
https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-020-00825-w/figures/1
Patterns of care among patients undergoing hepatic resection: A query of the National Surgical Quality Improvement Program...Patterns of care among patients undergoing hepatic resection: A query of the National Surgical Quality Improvement Program...
T2 - A query of the National Surgical Quality Improvement Program-targeted hepatectomy database ... A query of the National Surgical Quality Improvement Program-targeted hepatectomy database. Journal of Surgical Research, 196(2 ... A query of the National Surgical Quality Improvement Program-targeted hepatectomy database. In: Journal of Surgical Research. ... A query of the National Surgical Quality Improvement Program-targeted hepatectomy database, Journal of Surgical Research, vol ...
https://profiles.wustl.edu/en/publications/patterns-of-care-among-patients-undergoing-hepatic-resection-a-qu
Perturbed bioelectrical properties of the mouse cecum following hepatectomy and starvation: The role of bacterial adherence<...
The aim of this study was to further characterize these effects in the mouse cecum following hepatectomy and short-term ... The aim of this study was to further characterize these effects in the mouse cecum following hepatectomy and short-term ... The aim of this study was to further characterize these effects in the mouse cecum following hepatectomy and short-term ... The aim of this study was to further characterize these effects in the mouse cecum following hepatectomy and short-term ...
https://utsouthwestern.pure.elsevier.com/en/publications/perturbed-bioelectrical-properties-of-the-mouse-cecum-following-h
Successful completion of First Total Laparoscopic Right Hepatectomy in Greece | HYGEIA HospitalSuccessful completion of First Total Laparoscopic Right Hepatectomy in Greece | HYGEIA Hospital
The first total laparoscopic right hepatectomy in Greece was successfully performed at HYGEIA Hospital. ... Successful completion of First Total Laparoscopic Right Hepatectomy in Greece. 07 May 2019 ... year old patient was diagnosed with a mass in the right lobe of the liver and underwent a total laparoscopic right hepatectomy ...
https://www.hygeia.gr/en/press-release/successful-completion-of-first-total-laparoscopic-right-hepatectomy-in-greece/
Does Adjuvant Radiotherapy Suppress Liver Regeneration After Partial Hepatectomy? - Fingerprint - Ewha Womans University
Does Adjuvant Radiotherapy Suppress Liver Regeneration After Partial Hepatectomy?. Jin Hwa Choi, Kyubo Kim, Eui Kyu Chie, Jin ... Dive into the research topics of Does Adjuvant Radiotherapy Suppress Liver Regeneration After Partial Hepatectomy?. Together ...
https://pure.ewha.ac.kr/en/publications/does-adjuvant-radiotherapy-suppress-liver-regeneration-after-part/fingerprints/
Dissection 005, mai 2020 : ​​​Prevention of biliary fistula after partial hepatectomy by transcysticDissection 005, mai 2020 : ​​​Prevention of biliary fistula after partial hepatectomy by transcystic
Voici notre cinquième Dissection de lannée 2020 ! Écrite par le Dr Kayvan MOHKAM et le Pr Jean-Yves MABRUT (Lyon, Hôpital Croix Rousse) Adult Living Donor Versus Deceased Donor Liver Transplant (LDLT Versus DDLT) at a Single Center: Time to Change Our Paradigm for Liver Transplant ​ Auteurs : Humar A, Ganesh S, Jorgensen D, Tevar A, Ganoza A, Molinari M, Hughes C. Journal : Annals of Surgery 2019 Sep;270(3):444-451. Impact factor : 9,48 Bonne lecture. Nicolas Golse Pour lACHBT
https://www.achbt.org/single-post/2020/05/11/dissection-005-mai-2020-prevention-of-biliary-fistula-after-partial-hepatectomy-by-tra
UPMC Liver Cancer Center--Pittsburgh PAUPMC Liver Cancer Center--Pittsburgh PA
Outcomes of laparoscopic hepatectomy for HCC & CRC metastases. Presented by David Geller at the SAGES/ILLS Session: ...
https://www.sages.org/video-institution/upmc-liver-cancer-center-pittsburgh-pa/
Right hepatectomyLaparoscopicLeft hepatectomyHepatocellularPartial hepatectomy in ratsRegenerationPortal vein LigationHours after hepatectomyPostoperativeUnderwentRecurrenceHepaticTotal hepatectomyMethodsSurgicalDonorPHLFERASRatsResectionsOutcomesTumorVersusTissue2020KidneyPatientsAbdominalLiver functionDiagnosisPostMajorStudySignificantTreatment
Right hepatectomy7
  • A successful case of right hepatectomy in a patient with von Willebrand disease. (unil.ch)
  • Robotic surgery for performance of right hepatectomy is safe and effective. (unige.ch)
  • The first total laparoscopic right hepatectomy in Greece was successfully performed at HYGEIA Hospital. (hygeia.gr)
  • A 55 year old patient was diagnosed with a mass in the right lobe of the liver and underwent a total laparoscopic right hepatectomy. (hygeia.gr)
  • Aedes aegypti right hepatectomy was done. (cdc.gov)
  • Twenty- six patients underwent left hepatectomy, 20 patients had right hepatectomy and 11 patients trisegmentectomy. (turkjsurg.com)
  • In the paper by Gali et al titled "Right Hepatectomy for Living Liver Donation vs Right Hepatectomy for Disease: Intraoperative and Immediate Postoperative Comparison," published in the May issue of the Archives (2007;142[5]:467-472), an error occurred in the first paragraph of the text on page 467. (jamanetwork.com)
Laparoscopic3
  • With an established living donor liver transplant programme and expertise in laparoscopic liver resection, we performed our first laparoscopic living donor hepatectomy in March 2019. (skh.com.sg)
  • A laparoscopic donor hepatectomy offers the benefits of faster recovery, less pain and far superior cosmesis. (skh.com.sg)
  • This approach should be considered as a reasonable option in addition to conventional and laparoscopic approaches for major hepatectomies. (turkjsurg.com)
Left hepatectomy2
  • Then, left hepatectomy was performed. (hindawi.com)
  • The patient was taken to the operating room for a left hepatectomy. (medscape.com)
Hepatocellular4
  • Are We Sure that Blood Transfusion is Associated with Recurrence of Hepatocellular Carcinoma After Hepatectomy? (elsevier.com)
  • The 2/3 partial hepatectomy mouse model was used to further explore the effects of psoralen on the liver regeneration and hepatocellular cycle arrest in vivo . (frontiersin.org)
  • Recurrence of the hepatocellular carcinoma after hepatectomy [Time Frame: The time period between hepatectomy and the initial examination revealing a recurrence of hepatocellular carcinoma, or until the end of follow-up on December 31, 2020.whichever came first, assessed up to 60 months. (who.int)
  • Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy. (cdc.gov)
Partial hepatectomy in rats1
  • PURPOSE:To evaluate the influence of the anesthetic regimen on anesthetic recovery, survival, and blood glucose levels following a 90% partial hepatectomy in rats. (scite.ai)
Regeneration7
  • Gene expression related to early phase of liver regeneration at 6 hours after hepatectomy was decreased in encapsulated cells group, whereas genes related to regeneration were increased at 12, 24, and 48 hours. (scite.ai)
  • Liver regeneration ofter partial hepatectomy. (edu.pl)
  • The lipid messengers may be potent factors affecting process of liver regeneration after partial hepatectomy. (edu.pl)
  • Does Adjuvant Radiotherapy Suppress Liver Regeneration After Partial Hepatectomy? (ewha.ac.kr)
  • Dive into the research topics of 'Does Adjuvant Radiotherapy Suppress Liver Regeneration After Partial Hepatectomy? (ewha.ac.kr)
  • In this study, we found that Fak is activated and induced during liver regeneration after two-thirds partial hepatectomy (PHx). (luc.edu)
  • Bile accumulation in the peritoneal cavity after partial hepatectomy reduces hepatic regeneration. (elsevier.com)
Portal vein Ligation3
  • Associating Liver Partition with Portal vein ligation for Staged hepatectomy (ALPPS) versus Two-Stage Hepatectomy (TSH) for marginally resectable colorectal liver metastases - a multicentric, randomized controlled trial. (alpps.net)
  • Typically referred to as an ALPPS procedure, an associating liver partition and portal vein ligation for staged hepatectomy is one of today's most advanced treatments for liver cancer and metastasis to the liver from cancers originating in other organs (e.g., colon or rectal cancer). (moffitt.org)
  • Comment on Liver Venous Deprivation or Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy? (chirurgiehbp.ro)
Hours after hepatectomy3
  • Body temperature 24 hours after hepatectomy was significantly lower (36.5 ± 0.5°C vs. 38.2 ± 0.7°C) in the dummy device group. (biomedcentral.com)
  • Significant lower values were measured for blood lactate (1.9 ± 0.2 vs. 2.5 ± 0.5 mM/L) from 16 hours, creatinine (1.5 ± 0.2 vs. 2.0 ± 0.3 mg/dL) from 40 hours and ammonia (273 ± 122 vs. 1345 ± 700 μg/dL) from 48 hours after hepatectomy until death. (biomedcentral.com)
  • Another group was euthanized at 6, 12, 24, 48, and 72 hours after hepatectomy to study expression of cytokines and growth factors. (scite.ai)
Postoperative3
  • Groups of mice underwent a surgical hepatectomy and were either fed or starved during the postoperative period. (elsevier.com)
  • Postoperative phrenic nerve block significantly reduced severe post- hepatectomy shoulder pain . (bvsalud.org)
  • The '50-50 criteria' on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. (ijsurgery.com)
Underwent2
  • Patients with HCC who underwent hepatectomy and were pathologically diagnosed as MVI at the research center between January 2009 and December 2016 were retrospectively analyzed. (esmo.org)
  • Fifty-seven consecutive patients who underwent major hepatectomies performed via an UMI were compared to a control group of 36 patients who underwent major hepatectomies with a conventional incision (CI). (turkjsurg.com)
Recurrence1
  • The recurrence rate after hepatectomy remains high, which seriously affects the prognosis. (esmo.org)
Hepatic2
  • Background: The presence of communicating veins between adjacent hepatic veins may allow parenchyma-sparing hepatectomy. (elsevier.com)
  • Hepatic insufficiency and mortality in 1,059 noncirrhotic patients undergoing major hepatectomy. (ijsurgery.com)
Total hepatectomy1
  • Total hepatectomy was performed in ten female pigs followed by standardized intensive care support until death. (biomedcentral.com)
Methods1
  • Since 1990, a growing number of minimal invasive hepatectomy methods have been reported with favorable results. (turkjsurg.com)
Surgical3
  • Despite the rapid improvements and increasing range of surgical options, there remains a significant risk of developing Post-Hepatectomy Liver Failure (PHLF) - caused by inadequate remnant liver function after surgery. (bl.uk)
  • The aim of this study was to clarify the significant prognostic factors after hepatectomy for colorectal metastases, with special reference to the surgical margin. (elsevier.com)
  • Surgical resection, or partial hepatectomy (PH), is a potentially curative surgical treatment option for up to 15-20% of patients with HCC. (intechopen.com)
Donor3
  • Since then, all our living donor hepatectomies for adult-to-adult liver transplant have been performed laparoscopically. (skh.com.sg)
  • Upper midline incision (UMI) has been proven to be feasible, safe and effective in living donor major hepatectomy ( 10 , 11 ). (turkjsurg.com)
  • Hepatobiliary surgery: lessons learned from live donor hepatectomy. (medscape.com)
PHLF1
  • Post-hepatectomy liver failure (PHLF) represents a serious complication of liver resection. (ijsurgery.com)
ERAS2
  • We aimed to assess the economic impact of ERAS in hepatectomy from the perspectives of patients, hospitals and society, as well as identify the approach to create the economic benefits of ERAS. (biomedcentral.com)
  • Demographic data, those referring to the hepatectomy and the ERAS was analyzed. (scielo.br)
Rats3
  • Encapsulated cells or empty capsules were implanted in rats submitted to 90% partial hepatectomy. (scite.ai)
  • Long Evans rats were subjected to either partial hepatectomy (PH) or sham operation (SH) and were treated with liver cytosol (C) and cyclosporine (Cy). (bvsalud.org)
  • Nephrectomy and hepatectomy were applied to all rats at the end of the procedures, and blood samples were drawn from the inferior vena cava. (hitit.edu.tr)
Resections1
  • Of the total, 17 resections were major hepatectomies and in 18 simultaneous resections. (scielo.br)
Outcomes1
  • The aim of the study was to analyze the effect of sorafenib on the clinical outcomes in HCC patients with MVI after hepatectomy. (esmo.org)
Tumor1
  • With adequate tumor necrosis, a partial hepatectomy was successfully performed by a liver-transplant specialist from University of California San Diego Medical Center. (vin.com)
Versus2
  • This was a randomized, double-blind, placebo-controlled, pilot study , comparing ultrasound-guided phrenic nerve block ( ropivacaine 0.75 mg/mL) versus placebo (isotonic sodium chloride 0.9 mg/mL) on severe post- hepatectomy shoulder pain (NRS ≥6). (bvsalud.org)
  • 11 11 Le L, Jinming C, Zhonghua L, Qiang L, Ying S. "Enhanced recovery program versus traditional care after hepatectomy": Medicine 2017, 96: 38-44. (scielo.br)
Tissue2
  • In this case, a surgeon needs to leave enough healthy tissue after hepatectomy for the liver to function. (medicalnewstoday.com)
  • Prediction of small for size syndrome after extended hepatectomy: Tissue characterization by relaxometry, diffusion weighted magnetic resonance imaging and magnetization transfer. (ijsurgery.com)
20201
  • Post-operative survival time [Time Frame: Time from the end of hepatectomy to the patient's death, or the end of follow-up by December 31, 2020. (who.int)
Kidney2
  • IMSEAR at SEARO: Change in ascorbic acid content of kidney following partial hepatectomy in the garden lizard Calotes versicolor (Daudin). (who.int)
  • Group 1 was designated as the control group, and only nephrectomy (removal of the kidney) and hepatectomy (removal of the liver) were performed in this group. (hitit.edu.tr)
Patients3
  • The use of sorafenib after hepatectomy in HCC patients with MVI can prolong survival time. (esmo.org)
  • However, there is scant published data in the literature about its role in major hepatectomy for patients having malignant and benign indications. (turkjsurg.com)
  • Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
Abdominal1
  • A 65-year-old man with metastatic liver disease presented to the hospital with worsening abdominal pain after a partial hepatectomy and development of a large ventral hernia. (ahrq.gov)
Liver function1
  • Only people with otherwise healthy liver function are suitable for hepatectomy. (medicalnewstoday.com)
Diagnosis1
  • Gross examination of a liver sample from a right partial hepatectomy performed for diagnosis revealed multifocal tan-white nodules and necrotic or cystic spaces. (cdc.gov)
Post3
  • Phrenic nerve block on severe post-hepatectomy shoulder pain: A randomized, double-blind, placebo-controlled, pilot study. (bvsalud.org)
  • Ray S, Mehta NN, Golhar A, Nundy S. Post hepatectomy liver failure - A comprehensive review of current concepts and controversies. (ijsurgery.com)
  • Post-hepatectomy hyperbilirubinemia: The point of no return. (ijsurgery.com)
Major7
  • No patient had a formal major hepatectomy. (elsevier.com)
  • Optimal incision for major hepatectomy remains controversial. (turkjsurg.com)
  • In this study, we described our experience with a limited upper midline incision (UMI) for major hepatectomy. (turkjsurg.com)
  • The objective was to analyze the feasibility and safety of UMI in major hepatectomy. (turkjsurg.com)
  • Major hepatectomies can be safely performed through UMI. (turkjsurg.com)
  • Therefore, the role of minimally invasive approach in major hepatectomy is not clearly defined, especially if the resection can be accomplished directly through the same minimal incision needed for extracting the specimen and spare all of the above-mentioned burdens of the minimal invasive technique. (turkjsurg.com)
  • The aim of this study was to report our experience with major hepatectomy through UMI for malignant and benign indications and to analyze its feasibility and safety. (turkjsurg.com)
Study1
  • The aim of this study was to further characterize these effects in the mouse cecum following hepatectomy and short-term starvation, and to define the role of bacterial adherence in this process. (elsevier.com)
Significant1
  • A significant rise of endotoxin levels indicated the onset of sepsis at time of death in 60% (3/5) of the dummy device group animals surviving beyond 60 hours from hepatectomy. (biomedcentral.com)
Treatment1
  • Since then, hepatectomy has been widely performed for the treatment of various liver diseases, such as malignant tumors, benign tumors, calculi in the intrahepatic ducts, hydatid disease, and abscesses. (thesurgeon.club)
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