Excision of all or part of the liver. (Dorland, 28th ed)
Repair or renewal of hepatic tissue.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Tumors or cancer of the LIVER.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract.
A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
The transference of a part of or an entire liver from one human or animal to another.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
Tumors or cancer of the BILE DUCTS.
Veins which drain the liver.
Elements of limited time intervals, contributing to particular results or situations.
Pathological processes of the LIVER.
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
Loss of blood during a surgical procedure.
Experimentally induced tumors of the LIVER.
A malignant tumor arising from the epithelium of the BILE DUCTS.
The measurement of an organ in volume, mass, or heaviness.
Control of bleeding during or after surgery.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.
An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones.
The circulation of BLOOD through the LIVER.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
A bile pigment that is a degradation product of HEME.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A plant genus of the family LAMIACEAE that contains 5-methoxydehydropodophyllotoxin (a PODOPHYLLOTOXIN) and other LIGNANS.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Accumulation of purulent EXUDATES beneath the DIAPHRAGM, also known as upper abdominal abscess. It is usually associated with PERITONITIS or postoperative infections.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
An expression of the number of mitoses found in a stated number of cells.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Risk of major liver resection in patients with underlying chronic liver disease: a reappraisal. (1/2543)

OBJECTIVE: To explore the relation of patient age, status of liver parenchyma, presence of markers of active hepatitis, and blood loss to subsequent death and complications in patients undergoing a similar major hepatectomy for the same disease using a standardized technique. SUMMARY BACKGROUND DATA: Major liver resection carries a high risk of postoperative liver failure in patients with chronic liver disease. However, this underlying liver disease may comprise a wide range of pathologic changes that have, in the past, not been well defined. METHODS: The nontumorous liver of 55 patients undergoing a right hepatectomy for hepatocellular carcinoma was classified according to a semiquantitative grading of fibrosis. The authors analyzed the influence of this pathologic feature and of other preoperative variables on the risk of postoperative death and complications. RESULTS: Serum bilirubin and prothrombin time increased on postoperative day 1, and their speed of recovery was influenced by the severity of fibrosis. Incidence of death from liver failure was 32% in patients with grade 4 fibrosis (cirrhosis) and 0% in patients with grade 0 to 3 fibrosis. The preoperative serum aspartate transaminase (ASAT) level ranged from 68 to 207 IU/l in patients with cirrhosis who died, compared with 20 to 62 in patients with cirrhosis who survived. CONCLUSION: A major liver resection such as a right hepatectomy may be safely performed in patients with underlying liver disease, provided no additional risk factors are present. Patients with a preoperative increase in ASAT should undergo a liver biopsy to rule out the presence of grade 4 fibrosis, which should contraindicate this resection.  (+info)

Intrahepatic recurrence after curative resection of hepatocellular carcinoma: long-term results of treatment and prognostic factors. (2/2543)

OBJECTIVE: This study aimed to evaluate the long-term results of treatment and prognostic factors in patients with intrahepatic recurrence after curative resection of hepatocellular carcinoma (HCC). SUMMARY BACKGROUND DATA: Recent studies have demonstrated the usefulness of re-resection, transarterial oily chemoembolization (TOCE), or percutaneous ethanol injection therapy (PEIT) in selected patients with intrahepatic recurrent HCC. The overall results of a treatment strategy combining these modalities have not been fully evaluated, and the prognostic factors determining survival in these patients remain to be clarified. METHODS: Two hundred and forty-four patients who underwent curative resection for HCC were followed for intrahepatic recurrence, which was treated aggressively with a strategy including different modalities. Survival results after recurrence and from initial hepatectomy were analyzed, and prognostic factors were determined by univariate and multivariate analysis using 27 clinicopathologic variables. RESULTS: One hundred and five patients (43%) with intrahepatic recurrence were treated with re-resection (11), TOCE (71), PEIT (6), systemic chemotherapy (8) or conservatively (9). The overall 1-year, 3-year, and 5-year survival rates from the time of recurrence were 65.5%, 34.9%, and 19.7%, respectively, and from the time of initial hepatectomy were 78.4%, 47.2%, and 30.9%, respectively. The re-resection group had the best survival, followed by the TOCE group. Multivariate analysis revealed Child's B or C grading, serum albumin < or = 40 g/l, multiple recurrent tumors, recurrence < or = 1 year after hepatectomy, and concurrent extrahepatic recurrence to be independent adverse prognostic factors. CONCLUSIONS: Aggressive treatment with a multimodality strategy could result in prolonged survival in patients with intrahepatic recurrence after curative resection for HCC. Prognosis was determined by the liver function status, interval to recurrence, number of recurrent tumors, any concurrent extrahepatic recurrence, and type of treatment.  (+info)

Subcellullar localization, developmental expression and characterization of a liver triacylglycerol hydrolase. (3/2543)

The mechanism and enzymic activities responsible for the lipolysis of stored cytosolic triacylglycerol in liver and its re-esterification remain obscure. A candidate enzyme for lipolysis, a microsomal triacylglycerol hydrolase (TGH), was recently purified to homogeneity from pig liver and its kinetic properties were determined [Lehner and Verger (1997) Biochemistry 36, 1861-1868]. We have characterized the enzyme with regard to its species distribution, subcellular localization, developmental expression and reaction with lipase inhibitors. The hydrolase co-sediments with endoplasmic reticulum elements and is associated with isolated liver fat droplets. Immunocytochemical studies localize TGH exclusively to liver cells surrounding capillaries. Both TGH mRNA and protein are expressed in rats during weaning. The enzyme covalently binds tetrahydrolipstatin, an inhibitor of lipases and of triacylglycerol hydrolysis. The enzyme is absent from liver-derived cell lines (HepG2 and McArdle RH7777) known to be impaired in very-low-density lipoprotein (VLDL) assembly and secretion. The localization and developmental expression of TGH are consistent with a proposed role in triacylglycerol hydrolysis and with the proposal that some of the resynthesized triacylglycerol is utilized for VLDL secretion.  (+info)

Split liver transplantation. (4/2543)

OBJECTIVE: This study reviews the indications, technical aspects, and experience with ex vivo and in situ split liver transplantation. BACKGROUND: The shortage of cadaveric donor livers is the most significant factor inhibiting further application of liver transplantation for patients with end-stage liver disease. Pediatric recipients, although they represent only 15% to 20% of the liver transplant registrants, suffer the greatest from the scarcity of size-matched cadaveric organs. Split liver transplantation provides an ideal means to expand the donor pool for both children and adults. METHODS: This review describes the evolution of split liver transplantation from reduced liver transplantation and living-related liver transplantation. The two types of split liver transplantation, ex vivo and in situ, are compared and contrasted, including the technique, selection of patients for each procedure, and the most current results. RESULTS: Ex vivo splitting of the liver is performed on the bench after removal from the cadaver. It is usually divided into two grafts: segments 2 and 3 for children, and segments 4 to 8 for adults. Since 1990, 349 ex vivo grafts have been reported. Until recently, graft and patient survival rates have been lower and postoperative complication rates higher in ex vivo split grafts than in whole organ cadaveric transplantation. Further, the use of ex vivo split grafts has been relegated to the elective adult patient because of the high incidence of graft dysfunction (right graft) when placed in an emergent patient. Reasons for the poor function of ex vivo splits except in elective patients have focused on graft damage due to prolonged cold ischemia times and rewarming during the long benching procedure. In situ liver splitting is accomplished in a manner identical to the living donor procurement. This technique for liver splitting results in the same graft types as in the ex vivo technique. However, graft and patient survival rates reported for in situ split livers have exceeded 85% and 90%, respectively, with a lower incidence of postoperative complications, including biliary and reoperation for bleeding. These improved results have also been observed in the urgent patient. CONCLUSION: Splitting of the cadaveric liver expands the donor pool of organs and may eliminate the need for living-related donation for children. Recent experience with the ex vivo technique, if applied to elective patients, results in patient and graft survival rates comparable to whole-organ transplantation, although postoperative complication rates are higher. In situ splitting provides two grafts of optimal quality that can be applied to the entire spectrum of transplant recipients: it is the method of choice for expanding the cadaver liver donor pool.  (+info)

Hepatectomy for hepatocellular carcinoma: toward zero hospital deaths. (5/2543)

OBJECTIVE: The authors report on the surgical techniques and protocol for perioperative care that have yielded a zero hospital mortality rate in 110 consecutive patients undergoing hepatectomy for hepatocellular carcinoma (HCC). The hepatectomy results are analyzed with the aim of further reducing the postoperative morbidity rate. SUMMARY BACKGROUND DATA: In recent years, hepatectomy has been performed with a mortality rate of <10% in patients with HCC, but a zero hospital mortality rate in a large patient series has never been reported. At Queen Mary Hospital, Hong Kong, the surgical techniques and perioperative management in hepatectomy for HCC have evolved yearly into a final standardized protocol that reduced the hospital mortality rate from 28% in 1989 to 0% in 1996 and 1997. METHODS: Surgical techniques were designed to reduce intraoperative blood loss, blood transfusion, and ischemic injury to the liver remnant in hepatectomy. Postoperative care was focused on preservation and promotion of liver function by providing adequate tissue oxygenation and immediate postoperative nutritional support that consisted of branched-chain amino acid-enriched solution, low-dose dextrose, medium-chain triglycerides, and phosphate. The pre-, intra-, and postoperative data were collected prospectively and analyzed each year to assess the influence of the evolving surgical techniques and perioperative care on outcome. RESULTS: Of 330 patients undergoing hepatectomy for HCC, underlying cirrhosis and chronic hepatitis were present in 161 (49%) and 108 (33%) patients, respectively. There were no significant changes in the patient characteristics throughout the 9-year period, but there were significant reductions in intraoperative blood loss and blood transfusion requirements. From 1994 to 1997, the median blood transfusion requirement was 0 ml, and 64% of the patients did not require a blood transfusion. The postoperative morbidity rate remained the same throughout the study period. Complications in the patients operated on during 1996 and 1997 were primarily wound infections; the potentially fatal complications seen in the early years, such as subphrenic sepsis, biliary leakage, and hepatic coma, were absent. By univariate analysis, the volume of blood loss, volume of blood transfusions, and operation time were correlated positively with postoperative morbidity rates in 1996 and 1997. Stepwise logistic regression analysis revealed that the operation time was the only parameter that correlated significantly with the postoperative morbidity rate. CONCLUSION: With appropriate surgical techniques and perioperative management to preserve function of the liver remnant, hepatectomy for HCC can be performed without hospital deaths. To improve surgical outcome further, strategies to reduce the operation time are being investigated.  (+info)

Continuous versus intermittent portal triad clamping for liver resection: a controlled study. (6/2543)

OBJECTIVE: The authors compared the intra- and postoperative course of patients undergoing liver resections under continuous pedicular clamping (CPC) or intermittent pedicular clamping (IPC). SUMMARY BACKGROUND DATA: Reduced blood loss during liver resection is achieved by pedicular clamping. There is controversy about the benefits of IPC over CPC in humans in terms of hepatocellular injury and blood loss control in normal and abnormal liver parenchyma. METHODS: Eighty-six patients undergoing liver resections were included in a prospective randomized study comparing the intra- and postoperative course under CPC (n = 42) or IPC (n = 44) with periods of 15 minutes of clamping and 5 minutes of unclamping. The data were further analyzed according to the presence (steatosis >20% and chronic liver disease) or absence of abnormal liver parenchyma. RESULTS: The two groups of patients were similar in terms of age, sex, nature of the liver tumors, results of preoperative assessment, proportion of patients undergoing major or minor hepatectomy, and nature of nontumorous liver parenchyma. Intraoperative blood loss during liver transsection was significantly higher in the IPC group. In the CPC group, postoperative liver enzymes and serum bilirubin levels were significantly higher in the subgroup of patients with abnormal liver parenchyma. Major postoperative deterioration of liver function occurred in four patients with abnormal liver parenchyma, with two postoperative deaths. All of them were in the CPC group. CONCLUSIONS: This clinical controlled study clearly demonstrated the better parenchymal tolerance to IPC over CPC, especially in patients with abnormal liver parenchyma.  (+info)

Prolonged continuous or intermittent vascular inflow occlusion during hemihepatectomy in pigs. (7/2543)

OBJECTIVE: To assess ischemia and reperfusion (I/R) injury in a hemihepatectomy model in pigs after prolonged continuous or intermittent vascular inflow occlusion in the liver. SUMMARY BACKGROUND DATA: Massive intraoperative blood loss during liver resections can be prevented by temporary vascular inflow occlusion, consequently leading to ischemia and reperfusion injury in the remnant liver. Previously, in a pig liver resection model in which only limited I/R injury was induced during brief (90 min) vascular inflow occlusion, the authors demonstrated reduced I/R injury after continuous (CNT) occlusion, compared to intermittent (INT). This liver resection study on pigs was undertaken to assess I/R injury after prolonged (120 min) CNT or INT occlusion. METHODS: In pigs (37.0 +/- 1.5 kg), liver ischemia during 2 hours was CNT (n = 6) or INT (n = 6) (eight subsequent periods of 12 min ischemia and 3 min recirculation), followed by 6 hours of reperfusion. A left hemihepatectomy (45.5% +/- 1.4%) was performed within the first 12 minutes of ischemia. No hepatic pedicle clamping or liver resection was performed in control experiments (n = 6). Microvascular damage was assessed by hyaluronic acid (HA) uptake capacity of the liver (parameter of early sinusoidal endothelial cell damage) and restoration of intrahepatic tissue pO2 during reperfusion. Hepatocellular damage was tested by plasma concentrations of aspartate aminotransferase (AST), alanine aminotransferase, and lactate dehydrogenase (LDH). RESULTS: Hyaluronic acid uptake after 6 hours of reperfusion, compared to preischemic uptake, was unaltered in the control group, but was significantly reduced in both resection groups. However, more HA was taken up after INT occlusion, compared to CNT (60.4% +/- 5.6% and 39.5% +/- 3.7%, respectively; ANOVA: p = 0.001). Intrahepatic tissue pO2 distribution after 6 hours of reperfusion more closely returned to preischemic configuration in the INT group than in the CNT group, indicating reduced microcirculatory disturbances after INT occlusion. Release of AST and LDH after 6 hours of reperfusion was significantly increased in both CNT and INT groups. Lower AST levels, however, were found after INT occlusion than after CNT occlusion (267.0 +/- 74.7 U/l and 603.3 +/- 132.4 U/l, respectively; p = 0.06). CONCLUSIONS: Intermittent hepatic vascular inflow occlusion during prolonged liver ischemia in pigs resulted in less microcirculatory and hepatocellular injury, compared to continuous occlusion. Intermittent clamping is preferable when prolonged periods of vascular inflow occlusion are applied during liver resections.  (+info)

Quercetin inhibited DNA synthesis and induced apoptosis associated with increase in c-fos mRNA level and the upregulation of p21WAF1CIP1 mRNA and protein expression during liver regeneration after partial hepatectomy. (8/2543)

Quercetin, a widely distributed bioflavonoid, inhibited DNA synthesis in regenerating liver after partial hepatectomy. This inhibition was accompanied by apoptosis, evidenced by in situ end-labeling and gel electrophoresis of DNA fragmentation. Characteristic DNA fragmentation was detected as early as 2 h after injection. Northern blot analysis revealed that quercetin induced the increases in c-fos and p21WAF1CIP1 mRNA levels within 2 h. The expression of p21 protein was also enhanced, while p53 mRNA and protein levels were not affected by quercetin. These results suggest that quercetin-induced apoptosis is associated with the increase in c-fos mRNA level and the upregulation of p21 mRNA and protein expression, probably in a p53-independent pathway.  (+info)

TY - JOUR. T1 - Preoperative portal vein embolization with a new liquid embolic agent. AU - Ko, Gi Young. AU - Sung, Kyu Bo. AU - Yoon, Hyun Ki. AU - Kim, Jeong Ho. AU - Weon, Young Cheol. AU - Song, Ho Young. PY - 2003/5/1. Y1 - 2003/5/1. N2 - PURPOSE: To evaluate the effectiveness and safety of a new liquid embolic agent in preoperative portal vein embolization. MATERIALS AND METHODS: Embol-78 was obtained by means of hydrolysis of polyvinyl acetate and was dissolved in a mixture of ethanol and nonionic water-soluble contrast medium. After percutaneous puncture of the portal vein, embolization of the right portal vein was performed in 22 patients with hepatocellular carcinoma and in 29 patients with nonhepatocellular carcinoma. In each group, changes in volume of the future liver remnant, portal venous pressure, and liver enzymes were evaluated both before and after embolization. Complications were also evaluated. RESULTS: Portal vein embolization was successful in all patients, without major ...
The important considerations in determining indications for laparoscopic hepatectomy include tumor size, type and location. Nodular tumors smaller than 4 cm or pedunculated tumors smaller than 7 cm are suitable candidates. Concerning location, tumors in the lower segment and the left lateral segment are good candidates. Favourable operative procedure are partial hepatectomy and left lateral sectionectomy. Recently, we have successfully experienced of laparoscopic hepatectomy of recurrece HCC, Giant HCC or tumor located upper segment and hemihepatectomy. The operative procedures were 37 partial hepatectomy cases, 20 left lateral segmentectomy cases, 2 S6 segmentectomy , 2 posterior sectionectomy cases, 2 left hemihepatectomy cases and 1 right hemihepatectomy case ...
Introduction: We report our experience with laparoscopic major liver resection in Korea based on a multicenter retrospective study. Materials and methods: Data from 1,009 laparoscopic liver resections conducted from 2001 to 2011 were retrospectively collected. Twelve tertiary medical centers with specialized hepatic surgeons participated in this study. Results: Among 1,009 laparoscopic liver resections, major liver resections were performed in 265 patients as treatment for hepatocellular carcinoma, metastatic tumor, intrahepatic duct stone, and other conditions. The most frequently performed procedure was left hemihepatectomy (165 patients), followed by right hemihepatectomy (53 patients). Pure laparoscopic procedure was performed in 190 patients including 19 robotic liver resections. Hand-assisted laparoscopic liver resection was performed in three patients and laparoscopy-assisted liver resection in 55 patients. Open conversion was performed in 17 patients (6.4 %). Mean operative time and ...
Title: Portal Vein Embolization: A Preoperative Approach to Improve the Safety of Major Hepatic Resection. VOLUME: 2 ISSUE: 4. Author(s):David C. Madoff, Eddie K. Abdalla, Michael J. Wallace, Chaan S. Ng, Dario Ribero and Jean-Nicolas Vauthey. Affiliation:Interventional Radiology Section, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 325, Houston, Texas 77030-4009, USA.. Keywords:future liver remnant (FLR), liver regeneration, Computed tomography (CT), total liver volume (TLV), embolic materials. Abstract: Portal vein embolization (PVE) has become an important tool in the preoperative management of select patients prior to major hepatic resection. PVE redirects portal flow to the intended remnant liver to induce hypertrophy of the nondiseased portion of the liver and thereby may reduce complications and shorten hospital stays after surgery. This article reviews the rationale and existing ...
Bleeding is a major problem during liver resection. Vascular inflow occlusion, also known as Pringle maneuver, has been commonly employed to reduce blood loss during liver surgery. However, Pringle maneuver might cause ischaemic insult to the remnant liver and lead to post-operative liver dysfunction.. The investigators hypothesize that liver resection without the use of vascular inflow occlusion (Pringle maneuver) is associated with lower postoperative complications rate.. The aim of this study is to evaluate whether elective open liver resection without vascular inflow occlusion (Pringle Maneuvre) would lead to a reduction of post-operative surgical complications in patient with hepatocellular carcinoma.. Eligible patients undergoing liver resection in the Prince of Wales Hospital will be recruited and randomized into 2 study arms comparing the effect of Pringle maneuver. ...
TY - JOUR. T1 - Risk factors for early recurrence after curative hepatectomy for colorectal liver metastases. AU - Yamashita, Yo Ichi. AU - Adachi, Eisuke. AU - Toh, Yasushi. AU - Ohgaki, Kippei. AU - Ikeda, Osamu. AU - Oki, Eiji. AU - Minami, Kazuhito. AU - Sakaguchi, Yoshihisa. AU - Tsujita, Eiji. AU - Okamura, Takeshi. PY - 2011/4/1. Y1 - 2011/4/1. N2 - Purpose. With the broadening indications for hepatectomy to treat colorectal liver metastases (CRLM), early recurrence is a major problem. The aim of this study is to identify risk factors of early recurrence, defi ned as recurrence within 1 year after surgery. Methods. A retrospective analysis was performed on 121 consecutive patients who underwent hepatectomy for CRLM. Results. Among 121 patients, 52 (43.0%) developed early recurrence. The independent risk factor for early recurrence was number of liver metastases ≥3 (odds ratio 2.65). There were signifi cantly more patients with liver recurrence (51.9%) and recurrence beyond curative ...
Liver diseases are known to affect the function of remote organs. The aim of the present study was to investigate the effects of Pringle maneuver, which results in hepatic ischemia-reperfusion (IR) injury, and partial hepatectomy (Hx) on the pharmacokinetics and brain distribution of sodium fluorescein (FL), which is a widely used marker of blood-brain barrier (BBB) permeability. Rats were subjected to Pringle maneuver (total hepatic ischemia) for 20 min with (HxIR) or without (IR) 70% hepatectomy. Sham-operated animals underwent laparotomy only. After 15 min or 8 h of reperfusion, a single 25-mg/kg dose of FL was injected intravenously and serial (0-30 min) blood and bile and terminal brain samples were collected. Total and free (ultrafiltration) plasma, total brain homogenate, and bile concentrations of FL and/or its glucuronidated metabolite (FL-Glu) were determined by HPLC. Both IR and HxIR caused significant reductions in the biliary excretions of FL and FL-Glu, resulting in significant increases
BACKGROUND: Low central venous pressure (CVP) affects hemodynamic stability and tissue perfusion. This prospective study aimed to evaluate the optimal CVP during partial hepatectomy for hepatocellular carcinoma (HCC).. METHODS: Ninety-seven patients who underwent partial hepatectomy for HCC had their CVP controlled at a level of 0 to 5 mmHg during hepatic parenchymal transection. The systolic blood pressure (SBP) was maintained, if possible, at 90 mmHg or higher. Hepatitis B surface antigen was positive in 90 patients (92.8%) and cirrhosis in 84 patients (86.6%). Pringle maneuver was used routinely in these patients with clamp/unclamp cycles of 15/5 minutes. The average clamp time was 21.4+/-8.0 minutes. These patients were divided into 5 groups based on the CVP: group A: 0-1 mmHg; B: 1.1-2 mmHg; C: 2.1-3 mmHg; D: 3.1-4 mmHg and E: 4.1-5 mmHg. The blood loss per transection area during hepatic parenchymal transection and the arterial blood gas before and after liver transection were ...
Portal vein embolization (PVE) is an effective procedure to increase the future remnant liver (FRL) before major hepatectomy. A controversial issue is that PVE may stimulate tumor growth and can be associated with poor prognosis after liver resection for colorectal liver metastases (CRLM). The aim of this study was to evaluate the impact of PVE on long-term survival following major hepatectomy for CRLM.Between 1998 and 2010, 100 right and extended-right hepatectomies for unilobar, right-sided CRLM were performed. Of the group, 20 patients underwent preoperative PVE (group A). The control patients (group B; 20 patients) were selected by matching with the group A patients.It was found that 25 patients (25/40; 62.5\%) had developed tumor recurrence. The rate of global recurrence was not significantly different in groups A and B (65\% vs 60\%, respectively; P = .744). The specific overall intrahepatic recurrence rate was 42.5\% (17 of 40 patients) and was not significantly different in groups A and ...
Background Hepatocellular carcinoma has a poor prognosis; few patients can undergo surgical curative treatment according to Barcelona Clinic Liver Cancer guidelines. Progress in surgical techniques...
Eren Berber, MD. Cleveland Clinic. Objective: Over the last decade, techniques have been developed for laparoscopic liver resection (LLR). Still, one of the drawbacks is the dependency on multiple different devices for various steps of the procedure. Ideal would be to have a device that could be used to divide and provide hemostasis to the parenchyma, while also serving as a vessel sealer. Herein, we demonstrate a new 5 cm radiofrequency vessel sealing/dividing device (Caiman, Aesculap Inc., Center Vllaey, PA) that combines these features for LLR.. Methods: The device was used in 2 recent LLR cases. The first patient had ocular melanoma metastases in segment 3 and the second patient carcinoid metastases to segment 3.. Results: The first patient underwent laparoscopic left lateral sectionectomy using the Caiman vessel sealer and divider. The operation time was 89 minutes with an unremarkable blood loss. She was discharged home on postoperative day (POD) 2 and her drain was removed on POD 7. Final ...
Otte, Jean-Bernard ; Aronson, D ; Vraux, H. ; de Ville de Goyet, J ; Reding, Raymond ; et. al. Preoperative chemotherapy, major liver resection, and transplantation for primary malignancies in children.. In: Transplantation proceedings, Vol. 28, no. 4, p. 2393-4 (1996 ...
AB102. Laparoscopic versus open liver resection for tumours in the posterosuperior segments: a systematic review and meta-analysis
TY - JOUR. T1 - Non-heart-beating cadaver donor hepatectomy the operative procedure. AU - Olson, Les. AU - Davi, Richard. AU - Barnhart, Jay. AU - Burke, George. AU - Ciancio, Gaetano. AU - Miller, Joshua. AU - Tzakis, Andreas. PY - 1999. Y1 - 1999. KW - Cadaver donors. KW - Hepatectomy. KW - Operative procedure. UR - http://www.scopus.com/inward/record.url?scp=0032984247&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0032984247&partnerID=8YFLogxK. U2 - 10.1034/j.1399-0012.1999.130106.x. DO - 10.1034/j.1399-0012.1999.130106.x. M3 - Article. C2 - 10081644. AN - SCOPUS:0032984247. VL - 13. SP - 98. EP - 103. JO - Clinical Transplantation. JF - Clinical Transplantation. SN - 0902-0063. IS - 1 II. ER - ...
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Fretland, Åsmund Avdem; Dagenborg, Vegar Johansen; Bjørnelv, Gudrun Maria Waaler; Kazaryan, Airazat M.; Kristiansen, Ronny; Fagerland, Morten; Hausken, John; Tønnessen, Tor Inge; Abildgaard, Andreas; Barkhatov, Leonid; Yaqub, Sheraz; Røsok, Bård Ingvald; Bjørnbeth, Bjørn Atle; Andersen, Marit Helen; Flatmark, Kjersti; Aas, Eline & Edwin, Bjørn (2018). Laparoscopic Versus Open Resection for Colorectal Liver Metastases: The OSLO-COMET Randomized Controlled Trial. Annals of Surgery. ISSN 0003-4932. 267(2), s 199- 207 . doi: 10.1097/SLA.0000000000002353 Vis sammendrag Objective: To perform the first randomized controlled trial to compare laparoscopic and open liver resection. Summary Background Data: Laparoscopic liver resection is increasingly used for the surgical treatment of liver tumors.However, high-level evidence to conclude that laparoscopic liver resection is superior to open liver resection is lacking. Methods: Explanatory, assessor-blinded, single center, randomized superiority ...
Background: Reducing postoperative complications remains a dominant challenge for all clinicians. By minimizing the incidence of adverse outcomes, health care costs and patient recovery can be improved. A number of studies have documented that fewer postoperative adverse events occur with the preoperative use of glucocorticoids (GC). Two small manuscripts support the use of GC with particular reference to liver resection.. Major hepatectomy can be associated with numerous adverse outcomes (hemorrhage, bile leak, liver failure, wound infection other infectious complications). This rate approaches 54% in some trials. Additionally, the liver is responsible for numerous metabolic functions and actively participates in the acute phase response via the generation of inflammatory mediators and cytokines. Glucocorticoids play an important role in suppressing the over-synthesis of pro-inflammatory cytokines and therefore may assist in reducing postoperative complications. These pro-inflammatory cytokines ...
Totally laparoscopic living donor hepatectomy is a complex procedure with a steep learning curve requiring experienced teams with a commitment to technical excellence; it is not a random act but rather a gradual evolutionary process, decades in the making. See case reports by Samstein et al (page 2462), Soubrane et al (page 2467) and Troisi et al (page 2472). ...
It is not rare that two-stage hepatectomy for multiple bilobar colorectal liver metastases (CLM) be left incomplete because of disease progression or te
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Small for size and flow syndrome (SFSF) is one of the most challenging complications following extended hepatectomy (EH). After EH, hepatic artery flow decreases and portal vein flow increases per 100 g of remnant liver volume (RLV). This causes hypoxia followed by metabolic acidosis. A correlation between acidosis and posthepatectomy liver failure has been postulated but not studied systematically in a large animal model or clinical setting. In our study, we performed stepwise liver resections on nine pigs to defined SFSF limits as follows: step 1: segment II/III resection, step 2: segment IV resection, step 3: segment V/VIII resection (RLV: 75, 50, and 25%, respectively). Blood gas values were measured before and after each step using four catheters inserted into the carotid artery, internal jugular vein, hepatic artery, and portal vein. The pH, [Formula: see text], and base excess (BE) decreased, but [Formula: see text] values increased after 75% resection in the portal and jugular veins. EH ...
Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in patients with hepatocellular carcinoma : Liver resection for hepatocellular carcinoma (HCC) has the highest local controllability among all local treatments and results in a good survival rate. However, the recurrence rates of HCC continue to remain high even after curative hepatectomy Moreover, it has been reported that some patients with HCC have an early death due to recurrence. We analyzed the preoperative risk factors for early
TY - JOUR. T1 - Laparoscopic surgery for large left lateral liver tumors. T2 - safety and oncologic outcomes. AU - Yang, Tsung-Han. AU - Chen, Jen Lung. AU - Lin, Yih-Jyh. AU - Chao, Ying-Jui. AU - Shan, Yan-Shen. AU - Hsu, Hui-Ping. AU - Su, Che-Min. AU - Chou, Chung Ching. AU - Yen, Yi-Ting. PY - 2018/10/1. Y1 - 2018/10/1. N2 - Background: Although laparoscopic hepatectomy has been proven to be safe and reliable, the influence of tumor size on the feasibility of laparoscopic left lateral segmentectomy (LLLS) is unclear. We retrospectively reviewed our surgical results focusing on hepatic tumor located in the left lateral segment. Methods: From January 2003 to June 2016, patients who underwent left lateral segmentectomy were retrospectively reviewed, and data were collected on patient characteristics, peri-operative outcomes, and pathologic results. Patients with intrahepatic stone, cystic lesion, or unmeasurable tumor size were excluded. The continuous variables were compared using the ...
Malignant melanoma is an extremely aggressive cancer arising from melanocytes, associated with the development of metastases in up to 20% of patients. Although the liver is a frequent metastatic site of malignant melanoma, primary hepatic melanoma (PHM) is rare. The treatment of PHM is controversial, and the prognosis for affected patients remains poor. We present two PHM patients who underwent partial hepatectomy at our institution and review the clinical and pathological data from these cases. Our results suggest that it is difficult to make a preoperative diagnosis of PHM without pathological results. For patients with resectable PHM, surgical resection is a potentially curative treatment.
Gastroenterology Research and Practice is a peer-reviewed, Open Access journal that provides a forum for researchers and clinicians working in the areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis, and therapy of gastrointestinal diseases.
Background Hepatic resection is not applicable to the majority ofhepatocellular carcinoma (HCC) patients due to insufficient liverfunction reserve. Cardiotrophin-1 (CT-1), a member of the inter-leukin-6 family, has demonstrated protective and pro-proliferativeeffects in the myocytes and hepatocytes.Aim The present study aimed to investigate the potential role ofCT-1 in rescuing marginal cirrhotic liver remnant in a rat orthotopicHCC model.Materials and Methods Liver cirrhosis was induced by subcuta-neous injection of CCL4 for 8 weeks. The rat orthotopic HCC model was generated by injecting HCC cells into the left lobe of the liver.Animals received the following treatments: 1) hepatectomy only, n =6; 2) CT-1 (2 µg/kg) intraportal vein injection (i.pv) right after hepa-tectomy, n = 6; 3) CT-1 (2 µg/kg) i.pv right after hepatectomy, and 1µg/kg intraperitoneal injection (i.p) 24 hr after hepatectomy, n = 6; 4)CT-1 (2 µg/kg) i.p 24 hr before hepatectomy, n = 6; 5) CT-1 (2 µg/kg)i.p 24 hr before ...
Type beta transforming growth factor (TGF-beta), a factor produced by many cell types, is a potent inhibitor of hepatocyte DNA synthesis in vitro. To determine whether TGF-beta can influence hepatocyte proliferation in vivo, its effects were examined on the regenerative response of liver to partial hepatectomy (PH) in the rat. Porcine platelet-derived TGF-beta 1 (0.5 micrograms), administered intravenously at the time of PH and 11 hr later, reduced the fraction of hepatocytes engaged in DNA synthesis 22 hr after PH by 67% and inhibited the rate of hepatic [3H]thymidine incorporation by 50%. TGF-beta 2 produced a similar effect. A single dose of 0.5 micrograms of TGF-beta 1 given 11 hr after PH reduced liver [3H]thymidine incorporation by 32%; 4.5 micrograms of TGF-beta 1 or TGF-beta 2 inhibited DNA synthesis by 88% and the labeling index by 86%. Although sensitive to TGF-beta administered 11 hr after PH, late in the G1 phase of the cell cycle, a single dose of 0.5 micrograms given at the time of ...
OBJECTIVES To create a prediction model identifying futile outcome in ALPPS (Associating Liver Partition and Portal vein ligation for Staged hepatectomy) before stage 1 and stage 2 surgery. BACKGROUND ALPPS is a 2-stage hepatectomy, which incorporates parenchymal transection at stage 1 enabling resection of extensive liver tumors. One of the major criticisms of ALPPS is the associated high mortality rate up to 20%. METHODS Using the International ALPPS Registry, a risk analysis for futile outcome (defined as 90-day or in-hospital mortality) was performed. Futility was modeled using multivariate regression analysis and a futility risk score formula was computed on the basis of the relative size of logistic model regression coefficients. RESULTS Among 528 ALPPS patients from 38 centers, a futile outcome was observed in 47 patients (9%). The pre-stage 1 model included age 67 years or older [odds ratio (OR) = 5.7], and tumor entity (OR = 3.8 for biliary tumors) as independent predictors of futility ...
Transgenic mice expressing DN RAGE in cells of MP lineage display enhanced survival and liver regeneration after massive hepatectomy. Transgenic mice expressing human DN RAGE selectively in cells of MP lineage using the scavenger receptor type A promoter were used for these studies. (A-D) Immunofluorescence microscopy. Immunofluorescence for detection of RAGE antigen was performed in sections prepared from the remnants of transgenic mice 8 h after sham surgery (A) or massive resection (B, 85%). Double immunofluorescence staining was performed on sections prepared from transgenic mice 8 h after massive resection using the following antibodies: anti-RAGE IgG (C and D, green) and anti-CD68 IgG (C, red) or anti-CD11c IgG (D, red). Single and merged images are shown. (A and B) Bars, 100 μm; (C and D) Bars, 50 μm. (E) Kaplan-Meier Product Limit Estimate. The times of death were recorded for transgenic versus littermate control mice undergoing massive hepatectomy and survival was plotted. (F and G) ...
Expression of epigenetic factors in liver sinusoidal endothelial cells, partial hepatectomy, 30hr, biol_rep3 (CNhs14506.13603-146F3)
Diagnosis and treatment of cancer of the bile duct with partial hepatectomy (costs for program #275070) ✔ Klinik Im Park ✔ Department of General and Abdominal Surgery ✔ BookingHealth.com
In total, 248 patients were diagnosed with recurred liver metastasis between January 2003 and May 2016. Second and third hepatectomies were performed in 70 and 7 patients, respectively. The other 171 patients did not undergo a repeat hepatectomy. Clinical features were collected from the medical records. We analyzed survival rates of the repeat hepatectomy group and the nonrepeat hepatectomy group. We also investigated factors affecting overall and disease-free survival of patients who received a repeat hepatectomy using univariate and multivariate analyses ...
Right hepatectomy is a standard anatomical procedure used worldwide, and consists of two important steps: access to the portal pedicle at the hepatic hilus and approach through the right hepatic vein. With interest in the early work in the field of right hepatectomy, we searched for official documents, published not only in English but also non-English languages for insights on the history of the great work conducted by pioneer liver surgeons in the East and West. To discuss anatomical right hepatectomy, it is important to consider several issues, including liver anatomy, other anatomical liver resection procedures, control of vascular in-flow and out-flow, operative procedures or approaches, preoperative management and other related issues ...
Changes in binding of dexamethasone (9α-fluoro-11β, 17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione) to its receptors in regenerating rat liver after 70% hepatectomy were examined. Specific receptors for dexamethasone in the liver remnants of adrenalectomized rats decreased significantly during the period of DNA synthesis after 70% hepatectomy; then, they increased to above the control values between Days 4 and 7 after partial hepatectomy and subsequently returned to the control values. During the period of DNA synthesis, decreased binding was observed in partially hepatectomized rats with or without adrenals, but later enhanced binding was not prominent in rats with adrenals.. ...
Ellsmere, J., Kane, R. & Jones, D.B. Reply to: Re: Intraoperative ultrasonography during planned liver resections remains an important surgical tool ((2007) 21: 1280-1283). Surg Endosc 22, 1913 (2008). https://doi.org/10.1007/s00464-008-9942-8. Download ...
|p||p|Hydatidosis of the spleen (SH) is an extremally rare condition.|/p||p||bold|The aim of the study|/bold| was to present our experience and discuss diagnostic methods and therapeutical options in cases of spleen hydatidosis.|/p||p||bold|Material and methods.|/bold| Between 1993 and 2008, 8 patients were diagnosed with SH, 6 of whom were operated on (4 males and 2 females). Their average age was 44.5 years (the age range 30-59 years). Four patients presented isolated SH, one had a spleen and liver hydatidosis and there was also a case of one spleen, liver and peritoneal hydatidosis.|/p||p||bold|Results.|/bold| The main symptom of the condition was abdominal pain and hydatidosis serology was always positive. The average hydatidisis cyst size was 13.3 cm (range: 7-18 cm). Splenectomy was performed in 5 cases and a partial cystectomy in one case. A left lateral sectionectomy was required in 1 case, a segment III subsegmentectomy was delivered in 1 case and multiple cystectomies in the
Introduction Women with visceral metastases of breast cancer are usually considered to have a poor prognosis. A small subgroup of patients, however, present with liver metastases as the only manifestation of recurrence. The discussion whether this subgroup might benefit from an aggressive approach including liver resection is still ongoing and remains controversial. The decrease in mortality and morbidity rates has led to a broadening of the indication for hepatic resection. Design This was a case series study. Methodology Between January 2011 and December 2013, nine adult female patients underwent liver resection for liver metastases from breast cancer. Patients were considered for surgical management if they were fit for major operation; hepatic resection can be performed with adequate residual liver volume, intact inflow and outflow, and biliary drainage, and no extrahepatic disease on preoperative imaging except for limited and stable bone metastases. Hepatic resection was performed using ...
The first major liver resection (right hepatectomy) was performed by the ILC Team at Aster Hospital, Mankhool on a 28-year-old female who was incidentally detected to have an 11 cm hepatocellular carcinoma (HCC) in the right lobe of the liver. […]. ...
Objective(s) of the proposed study: - The evaluation of the efficiency of 18F deoxyglucose-Positron Emission Tomography (FDG-PET) in stag
Furthermore to these suggestions, diagnostic requirements including history of hepatitis; imaging features as given by the Liver organ Imaging Confirming and Data Program (LI-RADS) that are of help in evaluation of RHCC; previous RHCC recognition using BALAD and GALAD ratings; risk elements predicting RHCC after major resection; hepatectomy methods that lessen recurrence; and adjuvant treatments including antiviral real estate agents, molecular targeted therapy, systemic chemotherapy, and immunotherapy are referred to. Until now, proof supporting most therapeutic options for RHCC has been limited to cohort investigations. Randomized controlled studies have been few. Treatments have not been compared in terms of use at specific tumor stages. As a result, treatments useful for major tumors including medical resection frequently, liver organ transplantation, TACE, regional ablative therapy, and radiotherapy have already been put on recurrences empirically. As opposed to RHCC, many treatment ...
Hepatic resections are performed as a part of the surgical management for benign or malignant pathologies of the liver, while most of them are primary or secondary liver tumors. With the aid of this workshop, you will learn about the different types of hepatic resections, recall some of the liver anatomy and even test your knowledge of the hepatic blood supply and distribution. After laying the theoretical foundation, you will perform typical and atypical hepatic resections, and you will also become more familiar with the Pringle manoeuvre.. ...
BACKGROUND: LigaSure has been reported as a safe and effective approach for parenchymal transection in open hepatectomy; however, its roles in laparoscopic hepatectomy (LH) with liver cirrhosis have not been evaluated. The aim of this study was to compare the outcomes of LigaSure vs. Cavitron Ultrasonic Surgical Aspirator (CUSA) for LH in hepatocellular carcinoma (HCC) patients with cirrhosis.. METHODS: We retrospectively reviewed the medical records of 135 HCC patients with background cirrhosis who underwent pure LH using CUSA (n = 55) or LigaSure (n = 80) for parenchymal transection between January 2015 and May 2017 at West China Hospital of Sichuan University. We performed 1:1 propensity score matching between the LigaSure and CUSA groups. Subsequently, 48 patients were included in each group.. RESULTS: The mean parenchymal transection time (74.3 ± 23.6 vs. 86.3 ± 25.8 min, P = 0.019) in the LigaSure group was obviously shorter than that in the CUSA group. The LigaSure did not increase the ...
Background: Living donor liver transplantation remains the predominant option for patients with acute or chronic liver failure in many regions with poor cadaveric donation rates. Over the years, the donor mortality and donor liver failure has been minimized due to improvement in selection and surgical expertise. However like any major liver resections, the risk of bleeding, reoperations and readmissions remains. Aim: Analysis of Reoperation and Readmission rates following Living Donor Hepatectomy from a single center from Western India. Methods: Retrospective analysis of records of living donors who required re-exploration and / or readmissions after Living donor hepatectomy performed between April 2013 & October 2016 at a single center. Results: 137 Donor hepatectomies were done during this period (121 Right Liver grafts and 16 Left lobe and Left lateral segment grafts). The mean age of Donors was 36 years (20 to 58) with a male preponderance ( M/F :1.6/1). There was no mortality (30 day and 90 ...
The inflammatory response has been shown to be a major contributor to acute kidney injury. Considering that laparoscopic surgery is beneficial in reducing the inflammatory response, we compared the incidence of postoperative acute kidney injury between laparoscopic liver resection and open liver resection. Among 1173 patients who underwent liver resection surgery, 222 of 926 patients who underwent open liver resection were matched with 222 of 247 patients who underwent laparoscopic liver resection, by using propensity score analysis. The incidence of postoperative acute kidney injury assessed according to the creatinine criteria of the Kidney Disease: Improving Global Outcomes definition was compared between those 1:1 matched groups. A total 77 (6.6%) cases of postoperative acute kidney injury occurred. Before matching, the incidence of acute kidney injury after laparoscopic liver resection was significantly lower than that after open liver resection [1.6% (4/247) vs. 7.9% (73/926), P < 0.001]. ...
Background With the development of laparoscopic skills, its application has expanded in living donor liver transplantation. However, due to technical difficulties, pure laparoscopic donor hepatectomy (PLDH) is performed few centers. In this report, we compare the safety and early outcomes of PLDH and open donor hepatectomy (ODH). Moreover, the learning curve of each group was analyzed and compared during the experienced period.. Methods Total of 78 consecutive living liver donors underwent the right hepatectomy from January 2010 to March 2017. Of these, 43 living donors underwent the ODH and the 35 donors underwent the PLDH. Two donors of the PLDH group underwent open conversion due to bleeding and large graft size. The learning curve was defined using the moving average method.. Results Except for the size of the right portal vein (PLDH 13.4± 6.3 mm, ODH 10.8± 3.2; p=0.03) donor demographic including age, sex, body mass index (BMI), fatty change and vascular and biliary anomaly were ...
TY - JOUR. T1 - Hand-Assisted Laparoscopic Hepatectomy for Solid Tumor in the Posterior Portion of the Right Lobe. T2 - Initial Experience. AU - Huang, Ming Te. AU - Lee, Wei Jei. AU - Wang, Weu. AU - Wei, Po Li. AU - Chen, Robert J.. PY - 2003/11. Y1 - 2003/11. N2 - Objective: To prove the feasibility of hand-assisted laparoscopic liver resection for tumors located in the posterior portion of the right hepatic lobe. Summary Background Data: Use of laparoscopic liver resection remains limited due to problems with technique, especially when the tumor is located near the diaphragm, or in the posterior portion of the right lobe. Methods: Between October 2001 and June 2002, a total of 7 patients with solid hepatic tumors involving the posterior portion of the right lobe of liver underwent hand-assisted laparoscopic hepatectomy with the HandPort system at our hospital. Surgical techniques used included CO2 pneumoperitoneum and the creation of a wound on the right upper quadrant of the abdomen for ...
The process of liver regeneration after partial hepatectomy is very complex and is associated with signalling cascades involving initiation signals, transcription factors, cytokines, growth factors, tissue remodelling and termination of growth related signals. To date the exact mechanism of liver regeneration remains poorly understood. Toll-like receptor 4 (TLR4) acts as a sensor for immune signals and plays a critical role in host defence. It is known that lipopolysaccharide (LPS) is one of the ligands for TLR4. Binding of LPS to TLR4 leads to activation of transcription factor, nuclear factor kappa B (NF-κB) via the intracellular adaptor molecule, myeloid differentiation factor 88 (MyD88), which in turn activates the production of proinflammatory cytokines, TNF-α and IL-6. Evidence suggests that LPS/TLR4 signalling may be involved in liver regeneration following partial hepatectomy, as delayed liver regeneration and impaired cytokine responses were observed in C3H/HeJ mice, a mouse that is ...
Introduction: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been successfully applied to increase the future liver remnant before a right trisectionectomy. Tumor infiltration to the right portal vein is a challenge situation. Material and methods: A patient with advanced gallbladder carcinoma underwent exploration. Intraoperative finding showed tumor infiltration of the right portal vein and the duodenum. In-situ split of the left lateral liver lobe combined with postoperative right portal vein embolization completed the concept of ALPPS.. Results: Successful right trisectionectomy in combination with whipple operation without tumor residual could be achieved 8 days later, while the liver remnant increased from 491 ml to 911 ml. Neither post-hepatectomy liver failure nor postoperative anastomotic leak has been observed. 3 month follow up has not shown any sign of tumor recurrence. Conclusion: In-situ split combined with postoperative right portal vein ...
Studies on the hyperplasia (regeneration) of the rat liver following partial hepatectomy. Changes in lipid peroxidation and general biochemical aspects
Prabhakaran, K.,Patankar, Jahoorahmad M.V.,Neo, Grace T.H. (2004). Chylous ascites following liver resection - Case report. Pediatric Surgery International 20 (9) : 719-721. [email protected] Repository. https://doi.org/10.1007/s00383-004-1281-9 ...
Looking for online definition of anterior portion of left medial segment IV of liver in the Medical Dictionary? anterior portion of left medial segment IV of liver explanation free. What is anterior portion of left medial segment IV of liver? Meaning of anterior portion of left medial segment IV of liver medical term. What does anterior portion of left medial segment IV of liver mean?
Portal vein embolization (PVE) is a preoperative procedure performed in interventional radiology to initiate hypertrophy of the anticipated future liver remnant a couple weeks prior to a major liver resection procedure. The procedure involves injecting the right or left portal vein with embolic material to occlude portal blood flow. By occluding the blood flow to areas of the liver that will be resected away, the blood is diverted to healthy parts of the liver and induces hyperplasia. This may allow for a more extensive resection or stage bilateral resections that would otherwise be contraindicated resulting in better oncological treatment outcomes. Indications for PVE depend on the ratio of future liver remnant (FLR) to total estimated liver volume (TELV) and liver condition. Although there is no consensus to the absolute minimum liver volume required for adequate post-resection liver function, a FLR/TELV ratio of at least 25% in recommended in patients with otherwise normal livers. The ...
The aim of this study was to determine if the post-operative serum arterial lactate concentration is associated with mortality, length of hospital stay or complications following hepatic resection. Serum lactate concentration was recorded at the end of liver resection in a consecutive series of 488 patients over a seven-year period. Liver function, coagulation and electrolyte tests were performed post-operatively. Renal dysfunction was defined as a creatinine rise of |1.5x the pre-operative value. The median lactate was 2.8 mmol/L (0.6 to 16 mmol/L) and was elevated (≥2 mmol/L) in 72% of patients. The lactate concentration was associated with peak post-operative bilirubin, prothrombin time, renal dysfunction, length of hospital stay and 90-day mortality (P | 0.001). The 90-day mortality in patients with a post-operative lactate ≥6 mmol/L was 28% compared to 0.7% in those with lactate ≤2 mmol/L. Pre-operative diabetes, number of segments resected, the surgeons assessment of liver parenchyma, blood
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The Glissonean pedicle transection method has been reported to shorten operation time, reduce intraoperative blood loss, and minimize surgical risks in HCC patients undergoing hepatectomy 22. The Glissonean approach may therefore be more beneficial for HCC patients undergoing curative resection than other hilar vascular control methods such as the Pringle maneuver. However, in a large series, only 17.1% of patients underwent major hepatectomy involving two or more segments, with most patients (80.3%) undergoing segmentectomy or subsegmentectomy18. Our patient cohort differs in the extent of liver resection as well as including only patients with large (, 5 cm) nodular HCCs. 56% Of the 25 patients in our Glissonean group, 14 (56%) underwent removal of more than 2.5 segments (right trisegmetectomy).. To our best knowledge, our study is the first to compare the surgical effectiveness and safety of Glissonean transection with the Pringle maneuver in patients with large HCC undergoing radical ...
Blood purification, mainly plasma exchange (PE), was carried out for 13 cases of acute, and two cases of chronic postoperative liver failure. Four of thirteen acute cases (31%) survived. Although only one of eight with chronic liver disease survived, three of five without chronic liver disease survived. In most of those who lived, other organ failure occurred less often; total bilirubin and blood ammonia were less than 15 mg/dl and 200 micrograms/dl, respectively, before PE: and total bilirubin, blood ammonia, and branched chain amino acid/aromatic amino acid (BCAA/AAA) ratios recovered after five or fewer sessions of PE. Two chronic cases, treated for 1 and 4 years, respectively, were good candidates for liver or multiple organ transplantation. Although both died, PE was effective in reducing jaundice and in improving consciousness and general condition. Plasma exchange should be introduced early after assessing the changes in total bilirubin, blood ammonia, and coma grade in patients with acute
Stem cell factor (SCF) is a molecule with known proliferative effects on hematopoietic cells. More recent studies suggest that this molecule may also have effects on cellular differentiation and proliferation in other types of cells. The current investigations demonstrate that there is a large reservoir of SCF in the liver, that hepatic SCF levels change dramatically following partial hepatectomy in mice, and that SCF blockade, either by administration of anti-SCF antibodies or by using genetically altered, SCF-deficient mice, inhibits hepatocyte proliferation after partial hepatectomy; if SCF is replaced in the genetically SCF-deficient mice after partial hepatectomy, hepatocyte proliferation is restored to that seen in WT animals. Furthermore, SCF administration to IL-6 knockout mice also restores hepatocyte proliferation to normal. In vitro studies using primary mouse hepatocytes demonstrate that SCF causes hepatocyte proliferation and is induced by IL-6 and that treatment with anti-SCF ...
A delay in liver regeneration after partial hepatectomy (PHx) leads to acute liver injury, and such delays are frequently observed in aged patients. BubR1 (budding uninhibited by benzimidazole-related 1) controls chromosome mitotic segregation through the spindle assembly checkpoint, and BubR1 down-regulation promotes aging-associated phenotypes. In this study we investigated the effects of BubR1 insufficiency on liver regeneration in mice. Low-BubR1-expressing mutant (BubR1(L/L)) mice had a delayed recovery of the liver weight-to-body weight ratio and increased liver deviation enzyme levels after PHx. Microscopic observation of BubR1(L/L) mouse liver showed an increased number of necrotic hepatocytes and intercalated disc anomalies, resulting in widened inter-hepatocyte and perisinusoidal spaces, smaller hepatocytes and early-stage microvilli atrophy. Up-regulation of desmocollin-1 (DSC1) was observed in wild-type, but not BubR1(L/L), mice after PHx. In addition, knockdown of BubR1 expression caused
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It remains unclear if single incision laparoscopic liver surgery is superior to standard multiport resections and in what regard patients might benefit from this approach. We retrospectively analyzed the course of all patients undergoing laparoscopic left lateral sectionectomy at our center between 2009 and 2017. In total, 11 single incision and 31 multiport left lateral sectionectomies were performed at our center between July 2009 and May 2017. Six patients were excluded due to multivisceral resections. Indications included adenoma (n = 7 vs n = 2), focal nodular hyperplasia (n = 4 vs n = 3), hepatocellular carcinoma (n = 4 vs n = 4), colorectal liver metastasis (n = 4 vs n = 0), noncolorectal metastasis (n = 2 vs n = 1), hemangioma (n = 3 vs n = 0), abscess (n = 1 vs n = 0), and cysts (n = 1 vs n = 0 ...
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
Authors:. Fabrizio Di Benedetto MD PhD FACS, Paolo Magistri MD. Hepato-pancreato-biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy. Summary:. This is the case of a 67 years-old man affected by chronic HBV-related liver cirrhosis who was diagnosed with a large hepatocellular carcinoma (HCC) of the left lobe, AFP negative. On CT-scan the lesion was suspect for diaphragmatic infiltration and resulted to be close to the left portal vein. After multidisciplinary evaluation in our Institutional tumor board the patient was scheduled for left hepatectomy with robotic approach. On exploratory laparoscopy there was no diaphragmatic infiltration, therefore the procedure was carried on as planned.. Robotic approach for HCC on cirrhosis is particularly effective to reduce the risk of liver decompensation and improve post-operative outcomes, with lesser incidence of morbidity, shorter in-hospital stay and early return to daily life activity. Moreover, ...
To evaluate the effectiveness of omega-3 polyunsaturated fatty acid (ω-3 PUFA) administration on liver regeneration after 90% partial hepatectomy (PH) in rats. ω-3 PUFAs were intravenously injected in the ω-3 PUFA group before PH surgery. PH
TY - JOUR. T1 - Commentary on Yan et al.. T2 - Laparoscopic Liver Resection: A Review of Current Status. AU - Gruttadauria, Salvatore. PY - 2017/5/1. Y1 - 2017/5/1. UR - http://www.scopus.com/inward/record.url?scp=85019109983&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85019109983&partnerID=8YFLogxK. U2 - 10.1089/lap.2017.29017.sg. DO - 10.1089/lap.2017.29017.sg. M3 - Comment/debate. AN - SCOPUS:85019109983. VL - 27. SP - 487. EP - 488. JO - Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A. JF - Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A. SN - 1092-6429. IS - 5. ER - ...
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Liver regeneration requires spatially and temporally precisely coordinated proliferation of the two major hepatic cell populations, hepatocytes and liver sinusoidal endothelial cells (LSECs), to reconstitute liver structure and function. The underlying mechanisms of this complex molecular cross-talk remain elusive. Here, we show that the expression of Angiopoietin-2 (Ang2) in LSECs is dynamically regulated after partial hepatectomy. During the early inductive phase of liver regeneration, Ang2 down-regulation leads to reduced LSEC transforming growth factor-β1 production, enabling hepatocyte proliferation by releasing an angiocrine proliferative brake. During the later angiogenic phase of liver regeneration, recovery of endothelial Ang2 expression enables regenerative angiogenesis by controlling LSEC vascular endothelial growth factor receptor 2 expression. The data establish LSECs as a dynamic rheostat of liver regeneration, spatiotemporally orchestrating hepatocyte and LSEC proliferation ...
TUESDAY, Sept. 19, 2017 (HealthDay News) - For patients undergoing liver surgery, extended pharmacologic thromboprophylaxis appears effective and safe, according to a study published online Aug. 28 in the Journal of Thrombosis and Haemostasis.. Bradford J. Kim, M.D., M.H.S., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues examined the safety and efficacy of extended pharmacologic thromboprophylaxis in liver surgery for prevention of venous thromboembolism (VTE). A total of 124 patients who underwent liver resection for malignancy were placed on an extended pharmacologic thromboprophylaxis protocol. After discharge from the hospital, 91.1 percent of patients continued anticoagulant thromboprophylaxis to complete a course of 14 days after minor/minimally invasive hepatectomy or 28 days after major hepatectomy or VTE history.. The researchers found that the rates of intraoperative, postoperative, and overall transfusion were 5.6, 8.1, and 10.5 percent, ...
Liver cancer can be treated in a number of different ways. Some of the commonly used methods by which this ailment can be treated is liver resection which involves surgically removing that part of the liver which contains tumor; laparoscopic resection in which as compared to liver resection involves carrying out three to four incisions into the liver in order to remove the tumor present part of the liver. This is relatively a less complicated surgery to perform. Apart from these two, there are some additional different forms of treatments like Partial Hepatectomy in which that part of the liver is removed which contains tumor and the last one being, liver transplant, which is medically also known as Total Hepatectomy in which the liver is completely removed and replaced with another. On an average, cost of liver cancer surgery in India for resection costs somewhere around twenty thousand rupees approximately while for liver transplant it is slightly on the higher side. ...
Although variable prognostic factors (patient age, number and size of metastases, lymph node infiltration, stage of primary disease, prior local recurrence of the primary tumor, and clear resection margin of metastatic lesion) have been suggested in some reports, many authors describe the importance of hormone receptor status as a prognostic factor for the primary tumor after complete resection of BCLM [12,17,20]. Golse and Adam [23] suggested that the best results after the resection of BCLM are achieved after applying selection criteria based on small metastases (, 4-5 cm), minor hepatectomy, radical resection (ideally R0, or R1), stable disease after neoadjuvant therapy, and a delay between primary and secondary lesions longer than 1 or 2 years. Howerver, the age of the patient, her hormone receptor status, and HER2 overexpression are not strong predictors of overall survival [23]. In our study, time to recurrence was relatively short if the metastatic lesion was larger than 5 cm, or there ...
Background and Aim Hepatic resection involves not only complete removal of tumors but also preservation of optimal liver function after surgery. This study introduces the technique of inferior right...
When rats were subjected to partial hepatectomy, glucosamine 6-phosphate synthase (EC 5.3.1.19) of the remaining liver underwent alterations both in activity and in molecular form. To study the molecular alterations, glucosamine 6-phosphate synthase was purified from regenerating as well as control liver and was analyzed by isoelectric focusing. Although control liver exhibited only one form of glucosamine 6-phosphate synthase with a pl of 5.0, sequential and transient appearance of three other forms, with pl values of 4.3, 4.8, and 4.5, respectively, was observed for regenerating liver within 72 hr following partial hepatectomy. Laparotomy, on the other hand, induced in the liver only the pl 4.8 form, and injection of a mixture containing triiodothyronine, amino acids, glucagon, and heparin induced only the pl 4.3 and 4.5 forms. It therefore appears that the pl 4.3 and 4.5 forms, but not the pl 4.8 form, are associated with hepatic DNA synthesis. The pl 4.8 form is induced in the liver in ...
Aim: The objective was to evaluate whether contrast-enhanced magnetic resonance imaging (MRI) techniques used in a pre-operative assessment protocol for colorectal liver metastases are as accurate as spiral computer tomography during arterial portography (CTAP). Pre-operative accuracy and clinical consequences of MRI are described and compared with CTAP. Moreover, post-operative survival rate and tumour recurrence were studied. Methods: The study group comprised 84 patients which were possible candidates for a partial hepatectomy for colorectal liver metastases. Patients were pre-operatively evaluated by CT of the abdomen, CT of the thorax and spiral CTAP and ferumoxide-enhanced MRI was performed in routine way for all patients. Following this selection, 35 patients underwent a partial hepatectomy with curative intent. All patients were retrospectively evaluated. Results: Ferumoxide-enhanced MRI proved to be at least as accurate as spiral CTAP in 81% of patients. In nine patients (11%) spiral ...
BACKGROUND: Nurse-to-patient ratios in the intensive care unit are associated with postoperative mortality, morbidity, and costs after some high-risk surgery. OBJECTIVE: To determine if having 1 nurse caring for 1 or 2 patients (more nurses) versus 1 nurse caring for 3 or more patients (fewer nurses) in the intensive care unit at night is associated with differences in clinical and economic outcomes after hepatectomy. METHODS: Statewide observational cohort study of 569 adults who had hepatic resection, 1994 to 1998. Hospital discharge data were linked to a prospective survey of organizational characteristics in the intensive care unit. Multivariate analysis was used to determine the association of nighttime nurse-to-patient ratios with in-hospital mortality, length of stay, hospital costs, and specific postoperative complications. RESULTS: A total of 240 patients at 25 hospitals had fewer nurses; 316 patients in 8 hospitals had more nurses. No significant association between nighttime ...
Despite the use of alternative therapy strategies surgical resection of colorectal liver metastases remains the treatment of choice and is associated with long-term survival in a significant number of patients [1, 2]. After curative resection of colorectal liver metastases the 5-year survival rate ranges from 20% to 51% depending on preoperative selection criteria and published series [3]. However, up to 75% of resected patients will develop extra- or intrahepatic tumor recurrence [4]. One possible cause for this tumor recurrence may be intraoperative hematogenous tumor cell dissemination due to mechanical manipulation of the tumor during hepatic resection [5].. Recently, RT-PCR based protocols were developed for the detection of disseminated tumor cells [6]. We developed a sensitive and specific CK 20 RT-PCR system for detection of disseminated colorectal cancer cells in blood, bone marrow and lymph nodes [7-9]. By using the CK 20 RT-PCR, we demonstrated that there is a significantly enhanced ...
Our objective was to demonstrate the protective effect of glycine (Gly) and vitamin E (VE) on a model ofethanol-induced acute liver injury during the early phase of liver regeneration after partial hepatectomy(PH) in rats. Fifty male Wistar rats (body weight (b.w.), 240 - 280 g) were divided into four groups (n = 10,each, respectively) as follows: 1) control partial hepatectomy (PH), 70%; 2) PH + ethanol (EtOH) at 1.5g/kg b.w; 3) PH + Gly (0.6 g/kg b.w) + EtOH, and; 4) PH + VE (400 International units [IU]) + EtOH. Twentyfour h after surgery, animals were killed and liver damage and oxidative stress parameters weremeasured. Ethanol caused a decrease in serum albumin (2.27 vs 3.12 g/dL; p < 0.05), cholesterol (31.4vs 48.0 mg/dL; p < 0.05), Aspartate aminotransferase (AST, 70 vs 380 UI; p < 0.05), and alanineaminotransferase (ALT, 110 vs 170 UI; p < 0.05) in comparison with the PH control group, but thesedecreases were reverted with either Gly or VE administration. Furthermore, Gly and VE ...
Although liver regeneration occurring after partial hepatectomy (PH) is greatly reduced in aged mice, liver hyperplasia induced by xenobiotic mitogens was found to be age independent. Here, we investigated the potential utility of mitogens in stimulating liver regeneration in old mice subjected to two-third PH. Although virtually no hepatocytes entered S phase 48 h after PH, pretreatment (2 h prior to surgery) with 1,4-bis(2-(3,5-dichloropyridyloxy)benzene (TCPOBOP), a ligand of constitutive androstane receptor, induced an increase of bromodeoxyuridine incorporation and enhanced the expression of cyclin D1, cyclin A and proliferating cell nuclear antigen . Next, we investigated the potential utility of mitogens in the context of donor conditioning prior to living-related transplantation. Three days after TCPOBOP administration to intact young mice, an almost doubling of the liver mass and DNA content occurred; the regenerative response to two-third resection of the TCPOBOP-induced hyperplastic ...
In the liver, the JNK cascade is induced downstream of TNF receptors (TNFRs) in response to inflammatory, microbial, and toxic challenges. Sustained activation of JNK triggers programmed cell death (PCD), and hepatocyte survival during these challenges requires induction of the NF-κB pathway, which antagonizes this activation by upregulating target genes. Thus, modulation of JNK activity is crucial to the liver response to TNFR-mediated challenge. The basis for this modulation, however, is unknown. Here, we investigated the role of the NF-κB target Gadd45b in the regulation of hepatocyte fate during liver regeneration after partial hepatectomy. We generated Gadd45b-/- mice and found that they exhibited decreased hepatocyte proliferation and increased PCD during liver regeneration. Notably, JNK activity was markedly increased and sustained in livers of Gadd45b-/- mice compared with control animals after partial hepatectomy. Furthermore, imposition of a Jnk2-null mutation, attenuating JNK ...
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Purpose: The main difficulty with liver surgery is blood loss. It is hard in this case to achieve hemostasis because of the oozing bleeding. The aim of this study was to ..
Purpose The significant advantages of robotic surgery have expanded the scope of surgical procedures that can be performed through minimally invasive techniques. The aim of this study was to compare...
According to results recently published in the Archives of Surgery, a second surgery to remove colorectal cancer that has spread to the liver can significantly improve survival.. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. The liver is one of the most common places to which colorectal cancer spreads in its advanced stages. Cancer spread to the liver is referred to as liver metastasis.. Treatment for liver metastasis depends upon overall health of the patient, extent of spread, and anatomical location of the metastasis. Overall, surgical removal of cancer in the liver (hepatic resection) appears to provide the best outcomes. Surgeons often remove a part of the liver (hepatectomy) as well as the cancer. However, because outcomes following a second hepatic resection have not been clearly established, patients often undergo just one resection.. Researchers from France recently conducted a study to evaluate data including 40 patients with colorectal ...
The liver has an enormous capacity to regenerate, as demonstrated by the 2/3 partial hepatectomy model in rodents. In addition, the liver has a stem cell compar...
Discussion. The regenerative capacity of the liver was first described in ancient times, and dates back to Greek mythology:1 Prometheus, a titan and champion of mankind, stole fire from Zeus and presented it to humans. As punishment, Zeus sentenced Prometheus to eternal torment. He was incarcerated on a rock and each day an eagle was sent to feed on his swliver. Fortunately (or unfortunately!) the liver regenerated each night and the eagle returned daily, sentencing Prometheus to eternal torment.. Thankfully, the regenerative capacity of the liver forms the basis of modern hepatobiliary surgery, where in the presence of a noncirrhotic liver, up to 80% of the liver can safely be resected, relying on this regenerative capacity of the remnant to sustain the patients functional requirements.1 Liver resection progress has been significant in the last few decades and pivotal to a better understanding of liver anatomy and physiology.2. Glisson gave the first accurate insights into liver anatomy in ...
Garcea, G.; Ong, S.L.; Maddern, G.J. (2009). "Predicting liver failure following major hepatectomy". Digestive and Liver ...
One-year morbidity after donor right hepatectomy. Rudow DL, Brown RS Jr, Emond JC, Marratta D, Bellemare S, Kinkhabwala M. ...
Laparoscopic major hepatectomy: an evolution in standard care. Ann. Surg. 2009; 250:856-860. Nyugen KT, Steel J, Vanounou T, ...
Hepatectomy is the surgical resection of the liver. Hypophysectomy is the surgical removal of the pituitary gland or hypophysis ...
... enhances mouse liver regeneration after partial hepatectomy. Ursolic acid enhances the cellular immune system and ... "Ursolic acid enhances mouse liver regeneration after partial hepatectomy". Pharmaceutical Biology. 50 (4): 523-528. doi:10.3109 ...
It is useful for performing hepatectomies. The division divides the liver into two planes. It extends from the middle hepatic ... Cantlie's line is useful when performing hepatectomies. It was first described by Scottish surgeon James Cantlie in 1887 when ...
With resistant infection, a surgical hepatectomy or hepaticocutaneousjejunostomy can be performed. Lifelong surveillance for ...
These anatomic facts permitted the development of hepatectomies. His book Le Foie: Études anatomiques et chirurgicales stands ...
Li H, Zheng J, Cai JY, Li SH, Zhang JB, Wang XM, Chen GH, Yang Y, Wang GS (November 2017). "VS open hepatectomy for ...
"A Novel Mitochondrial Carnitine-acylcarnitine Translocase Induced by Partial Hepatectomy and Fasting". Journal of Biological ...
... has also been suggested as a biomarker for hepatectomy-induced liver injury in patients with hepatocellular carcinoma. ... "Correlation between plasma miR-122 expression and liver injury induced by hepatectomy". J Int Med Res. 42 (1): 77-84. doi: ...
Man, Kwan; Fan, Sheung-Tat (1999-05-01). "Tolerance of the Liver to Intermittent Pringle Maneuver in Hepatectomy for Liver ... Right Hepatectomy", Surgical Pitfalls, Philadelphia: W.B. Saunders, pp. 329-338, ISBN 978-1-4160-2951-9, retrieved 2021-01-25 ... "Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized study". Annals of Surgery. 226 (6): ...
Santos, CC; Onofre-Nunes, Z; Andrade, ZA (2007). "Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis ...
Studies on partial hepatectomy, liver regeneration and transplantation are items of this program. Innovation in Applied Medical ...
There are two events in which the liver has the capability to regenerate, one being a partial hepatectomy and the other being ... This priming phase occurs within 0-5 hours after the hepatectomy and deals mainly with events prior to entering the cell cycle ... Following the event of partial hepatectomy, there are three phases for the process of regeneration. The first phase is the ... Immediately after a hepatectomy, there is an activation of numerous signaling pathways that start the process of regeneration. ...
He introduced Vagotomy and was known to have performed his first Hepatectomy there. He stayed in Thanjavur for 5 years and ...
Hepatectomy Pancreatectomy Children's poetry "Specialist in pancreatic and liver surgery joins St. Agnes Hospital". The ...
... however now there may be a role of PVE in combination with a two-stage hepatectomy. Additionally, patients who have an ... "Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome". British Journal ...
"Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy". Acta Cirurgica Brasileira. ...
Surgical resection, partial hepatectomy, and embolization of afferent vessels should be considered for severe cases. Low power ...
"Comparison of Right Lobe Donor Hepatectomy with Elective Right Hepatectomy for Other Causes in New York". Dig Dis Sci. 56 (6): ... "Comparison of Right Lobe Donor Hepatectomy with Elective Right Hepatectomy for Other Casuses in New york". Dig Dis Sci. 56 (6 ...
Prediction of postoperative outcome after hepatectomy with a new bedside test for maximal liver function capacity. Annals of ... Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and ...
PMID 6692410 Jirtle RL, Michalopoulos G (1982), "Effects of partial hepatectomy on transplanted hepatocytes", Cancer Res. 42: ...
This may be accomplished by resection the affected portion of the liver (partial hepatectomy) or in some cases by orthotopic ... which may qualify the patient for a partial hepatectomy. Embolization is performed by an interventional radiologist using a ... transplantation is not associated with improved survival compared to hepatectomy, but instead is significantly more expensive. ... "A Prospective Randomized Trial Comparing Percutaneous Local Ablative Therapy and Partial Hepatectomy for Small Hepatocellular ...
Alican, Fikri; Çayırlı, Mukadder; Keith, Virginia (March 1971). "One-Stage Hepatectomy in the Dog with Restoration of the Vena ... Replantation of the Liver in Dogs Following Total Hepatectomy]". Türk Tıp Cemiyeti Mecmuası. 33 (4): 209-226. ISSN 0494-2736. ...
July 2011). "Refining the definition of perioperative mortality following hepatectomy using death within 90 days as the ...
2002). "ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane". ...
... are usually treated with partial hepatectomy. Various series have reported survival estimates after surgery ranging from 22-66 ...
When the disease is localized to one hepatic lobe, hepatectomy relieves symptoms and appears to remove the risk of malignancy. ...
2003). "HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions ...
Purpose Hepatectomies are performed to surgically remove tumors from the liver. ... Hepatectomy Definition A hepactectomy is the surgical removal of the liver. ... Hepatectomy. Definition. A hepactectomy is the surgical removal of the liver.. Purpose. Hepatectomies are performed to ... A hepatectomy is the surgical removal of the liver.. Purpose. Hepatectomies are performed to surgically remove tumors from the ...
Partial hepatectomies are also performed to remove a portion of a liver from a live donor for transplantation. A hepatectomy is ... Hepatectomies may be anatomic, i.e. the lines of resection match the limits of one or more functional segments of the liver as ... Hepatectomy is the surgical resection (removal of all or part) of the liver. While the term is often employed for the removal ... The first hepatectomies were reported by Dr. Ichio Honjo (1913-1987) of (Kyoto University) in 1949, and Dr. Jean-Louis Lortat- ...
Background The efficacy of repeat hepatectomy for recurrent hepatocellular carcinoma and colorectal liver metastases is widely ... repeat hepatectomy for recurrent gastric cancer liver metastasis may offer the same chance of cure as the primary hepatectomy. ... Adam R, Bismuth H, Castaing D et al (1997) Repeat hepatectomy for colorectal liver metastases. Ann Surg 225:51-60PubMedCrossRef ... Among them, repeat hepatectomy was performed in 14 of the 37 patients with intrahepatic recurrence. Among these 14 patients, ...
Laparoscopic Hepatectomy Under Epidural Anesthesia. Yamamoto, Kentaroh MD, PhD; Ishizawa, Takeaki MD, PhD; Kokudo, Norihiro MD ... Home , August 2014 - Volume 260 - Issue 2 , Laparoscopic Hepatectomy Under Epidural Anesthesia ...
Liver cancer treatments include surgery or hepatectomy liver transplants, embolization or chemoembolization, Radiofrequency ... A partial hepatectomy is the surgical removal of the part of the liver affected by cancer. This procedure may be an option for ...
When a subtotal hepatectomy could not be performed, total hepatectomy (THx) with liver transplantation was a valuable option. ... Treatment of fibrolamellar hepatoma with subtotal hepatectomy or transplantation Hepatology. 1997 Oct;26(4):877-83. doi: ... Follow-up studies are available from 1 year to 27 years, after 41 patients with FL-HCC were treated with partial hepatectomy ( ...
... clinicaltrials.gov Maintaining a low central venous pressure during living donor hepatectomy is routine practice. The ... Is Enhanced One-Stage Hepatectomy a Safe and Feasible Alternative to the Two-Stage Hepatectomy in the Setting of Multiple ... Two-stage hepatectomy (TSH) is the present standard for multiple bilobar colorectal metastases (CLM). As alternative, ... More From BioPortfolio on "Milrinone During Living Donor Hepatectomy". *Related Companies*Related Events*Related Clinical ...
Single incision partial hepatectomy is a new procedure than can be considered in appropriate candidates. While some of the ... Single Incision Laparoscopic Partial Hepatectomy. Introduction: Hepatocellular carcinoma is one of the most common tumors ...
Laparoscopic Caudate Hepatectomy for Cancer. Kuo Hsin Chen, MD, Hsin-An Chen, MD, Chao-Chiang Tu, MD, Jiann-Ming Wu, MD, Kuo- ... From February 2006 to July 2010, we have performed laparoscopic hepatectomy for eight consecutive patients (six male two female ... Our experience demonstrated that laparoscopic hepatectomy is a safe and feasible procedure for caudate hepatic tumors in ... To assess the safety, feasibility and clinical results of laparoscopic caudate hepatectomy for malignancy. ...
Preoperative Glucocorticoid Use in Major Hepatectomy. The safety and scientific validity of this study is the responsibility of ... Major hepatectomy can be associated with numerous adverse outcomes (hemorrhage, bile leak, liver failure, wound infection other ... no administration of 500 mg of methylprednisolone (MP) within 30 minutes of starting a hepatectomy. This trial will employ ... Elective surgery patients (adults) scheduled to undergo hepatectomy at FMC from May 2013 to May 2015. ...
... is to discuss whether these indexes could predict prognosis in patients with hepatocellular carcinoma undergoing hepatectomy.,i ... R. Liao, Y.-P. Fu, T. Wang et al., "Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy ... Fibrosis-4 Model Influences Results of Patients with Hepatocellular Carcinoma Undergoing Hepatectomy,. BioMed Research ... For example, some drug therapies (such as antineoplastic drugs) or presentation of steatohepatitis prior to hepatectomy has the ...
Outcome of partial hepatectomy for large (,10 cm) hepatocellular carcinoma LIAU KH ... Selection criteria for repeated hepatectomy in patients with recurrent hepatocellular carcinoma MINAGAWA M ...
1-year recurrence rate [ Time Frame: 1-year after hepatectomy ]. The 1-year recurrence rate after hepatectomy in both arms of ... Experimental: Hepatectomy plus TACE Transarterial chemoembolisation will be performed 4 to 6 weeks after hepatectomy ... RCT on Adjuvant TACE After Hepatectomy for HCC (A-TECH). This study is currently recruiting participants. See Contacts and ... We conduct a randomised controlled trial evaluating the efficacy of using TACE after hepatectomy in HCC patients. ...
Excision of tissue during a hepatectomy (surgical resection of the liver). In this case, a secondary hepatic deposit from a ... Hepatectomy is used to remove benign or malignant neoplasm (abnormal tissue growth) in the liver, malignant neoplasms commonly ... Excision of tissue during a hepatectomy (surgical resection of the liver). In this case, a secondary hepatic deposit from a ...
... Carolina Uribe-Cruz,1,2 ... Partial Hepatectomy," Stem Cells International, vol. 2016, Article ID 4831524, 9 pages, 2016. https://doi.org/10.1155/2016/ ...
It is appropriate for patients undergoing a hepatectomy for primary and secondary tumors of the liver. If you are a patient, we ... or shortly after a hepatectomy (surgery to remove part or all of the liver) for liver cancer. ... What is the patients platelet count before the hepatectomy?. x 103/mm3 (20 to 1200) What is a platelet?. A platelet refers to ... What is the patients hemoglobin level before the hepatectomy?. g/mL (3 to 30) What is hemoglobin?. Hemoglobin refers to a ...
Recent improvements in imaging technologies have enabled surgeons to perform precise planning using virtual hepatectomy (VH). ... How Has Virtual Hepatectomy Changed the Practice of Liver Surgery?: Experience of 1194 Virtual Hepatectomy Before Liver ... Liver resection 3D simulation Virtual hepatectomy Colorectal liver metastases Parenchymal-sparing hepatectomy Anatomical ... A novel 3D hepatectomy simulation based on liver circulation: application to liver resection and transplantation. Hepatology. ...
Liver weight/total body weight ratios and BrdU staining in WT and IL-6 knockout mice after 70% hepatectomy with and without SCF ... Beginning 72 hours after hepatectomy, liver weight/total body weight ratios in IL-6 knockout mice treated with vehicle are ... At 36 hours after hepatectomy, there was a significant increase in hepatocyte proliferation in IL-6 knockout animals treated ... all other groups). By 60 hours after hepatectomy, proliferation in IL-6 knockout mice treated with vehicle was still ...
Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy. ... Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy. ... if SCF is replaced in the genetically SCF-deficient mice after partial hepatectomy, hepatocyte proliferation is restored to ... that hepatic SCF levels change dramatically following partial hepatectomy in mice, and that SCF blockade, either by ...
Activated HSCs overexpress p75NTR after partial hepatectomy and undergo apoptosis on NGF stimu. September 29, 2006. ... NTs and their receptors were investigated by RT-PCR and immunostaining in regenerating livers after two-thirds hepatectomy (PH ...
The CT scan shows a 20X15cm right lobe mass. There was no evidence of extrahepatic tumor on the abdominal CT, and CT of the chest and bone scan were both normal. Core needle biopsy of the mass showed non-fibrolamellar hepatocellular carcinoma. Upper endoscopy and colonoscopy were normal. Bilirubin was 0.7 and liver enzymes were normal. Hepatitis serologies were normal. Alphafetoprotein was over 230,000. Notes ...
Decreased hepatic PC/PE is a predictor of NAFLD and survival following partial hepatectomy. Choline supplementation may serve ... To determine if decreased hepatic PC/PE could predict survival after hepatectomy, we used mouse models lacking key enzymes in ... We then performed a 70% partial hepatectomy and monitored postoperative survival. We identified hepatic PC/PE to be inversely ... Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice Hepatology ...
Laparoscopic Live Donor Hepatectomy: Random Mutation or Stepwise Evolution?. Authors. *. M. E. Akoad,. *Department of ... Talia B. Baker, Felicitas Koller, Juan Carlos Caicedo, Minimally Invasive Living Donor Hepatectomy, Current Transplantation ... Totally laparoscopic living donor hepatectomy is a complex procedure with a steep learning curve requiring experienced teams ... Totally laparoscopic living donor right hepatectomy in a donor with trifurcation of bile duct, Asian Journal of Surgery, 2016, ...
Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat. W ... Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat ... Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat ... Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat ...
Methods We performed 70%-hepatectomy in wild type (WT) mice, IL-1ra knock-out (KO) mice and in WT mice treated by anakinra. We ... Results At 24h and at 48h after hepatectomy, IL-1ra KO mice had significantly higher levels of pro-inflammatory cytokines (IL-6 ... Partial hepatectomy Is the Subject Area "Partial hepatectomy" applicable to this article? Yes. No. ... Hepatectomy Is the Subject Area "Hepatectomy" applicable to this article? Yes. No. ...
It is not rare that two-stage hepatectomy for multiple bilobar colorectal liver metastases (CLM) be left incomplete because of ... LONG-TERM RESULTS AFTER ONE-STAGE ULTRASOUND-GUIDED HEPATECTOMY IN PATIENTS WITH MULTIPLE BILOBAR COLORECTAL LIVER METASTASES: ... LONG-TERM RESULTS AFTER ONE-STAGE ULTRASOUND-GUIDED HEPATECTOMY IN PATIENTS WITH MULTIPLE BILOBAR COLORECTAL LIVER METASTASES: ...
Portal vein embolisation (PVE) can be used to increase the remnant liver parenchyma volume before major hepatectomy but may ... Long-term survival and disease recurrence following portal vein embolisation prior to major hepatectomy for colorectal ... undergoing extended right/right hepatectomy for CRC metastases without PVE during the same time period. ...
Remote Ischemia Precondition (RIPC) for Hepatic Protection in Patients Undergoing Hepatectomy. The safety and scientific ...
Poor outcomes after hepatectomy in patients with ascites infected by methicillin-resistant staphylococci * * Nitta Hidetoshi ...
... partial hepatectomy (PH) in rats. ω-3 PUFAs were intravenously injected in the ω-3 PUFA group before PH surgery. PH ... Hepatectomy* / adverse effects. Inflammation Mediators / blood. Injections, Intravenous. Liver / drug effects*, metabolism, ... RESULTS: All rats in the control group died within 30 h after hepatectomy. Survival rates in the ω-3 PUFA group were 20/20 at ... partial hepatectomy (PH) in rats.. METHODS: ω-3 PUFAs were intravenously injected in the ω-3 PUFA group before PH surgery. PH, ...
  • The efficacy of repeat hepatectomy for recurrent hepatocellular carcinoma and colorectal liver metastases is widely accepted. (springer.com)
  • Minagawa M, Makuuchi M, Takayama T et al (2003) Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma. (springer.com)
  • Wu CC, Cheng SB, Yeh DC et al (2009) Second and third hepatectomies for recurrent hepatocellular carcinoma are justified. (springer.com)
  • Our aim is to discuss whether these indexes could predict prognosis in patients with hepatocellular carcinoma undergoing hepatectomy. (hindawi.com)
  • Pure laparoscopic hepatectomy versus open hepatectomy for hepatocellular carcinoma in 110 patients with liver cirrhosis: a propensity analysis at a single center. (springermedizin.at)
  • Methods: We retrospectively reviewed data from 331 patients who underwent hepatectomy for hepatocellular carcinoma between January 2007 and December 2015. (eur.nl)
  • For hepatocellular carcinoma (HCC) patients with macrovascular invasion (MaVI), hepatectomy and transcatheter arterial chemoembolization (TACE) remain the main treatment options in Asia. (jcancer.org)
  • Chen J, Huang J, Chen M, Yang K, Chen J, Wang J, Xu L, Zhou Z, Zhang Y. Transcatheter arterial chemoembolization (TACE) versus hepatectomy in hepatocellular carcinoma with macrovascular invasion: a meta-analysis of 1683 patients. (jcancer.org)
  • 2014). 'Clinical Study of Hepatectomy Combined with Jianpi Huayu Therapy for Hepatocellular Carcinoma', Asian Pacific Journal of Cancer Prevention , 15(14), pp. 5951-5957. (waocp.org)
  • Background: The safety and feasibility of hepatectomy for hepatocellular carcinoma (HCC) in the elderly population have not been defined to date. (elsevier.com)
  • abstract = "Background: The safety and feasibility of hepatectomy for hepatocellular carcinoma (HCC) in the elderly population have not been defined to date.Methods: A single-center, retrospective cohort study was conducted with 104 patients who underwent hepatectomy for HCC from 2005 to 2010. (elsevier.com)
  • This prospective study aimed to evaluate the optimal CVP during partial hepatectomy for hepatocellular carcinoma (HCC). (qxmd.com)
  • Inflammatory indexes in preoperative blood routine to predict early recurrence of hepatocellular carcinoma after curative hepatectomy . (wroc.pl)
  • The incidence of hepatocellular tumors was increased after partial hepatectomy and correlated with both the number of cells synthesizing DNA at injection and the number of cells in mitosis. (edu.au)
  • PURPOSE: To evaluate the therapeutic efficacy and safety of percutaneous radiofrequency (RF) ablation for recurrent hepatocellular carcinoma (HCC) in the liver after hepatectomy. (elsevier.com)
  • Objective: The authors report on the surgical techniques and protocol for perioperative care that have yielded a zero hospital mortality rate in 110 consecutive patients undergoing hepatectomy for hepatocellular carcinoma (HCC). (hku.hk)
  • Study findings suggest that partial hepatectomy 5-year survival rates are highest among hepatocellular carcinoma (HCC) patients with a tumor status within the Milan criteria who have underlying chronic hepatitis or a solitary tumor of 5 cm or less in size. (medwirenews.com)
  • A case of hepatocellular carcinoma treated by transcatheter arterial chemoembolization and hepatectomy after subtotal stomach preserving pancreaticoduodenectomy for duodenal cancer]. (elsevier.com)
  • Major hepatectomy can be associated with numerous adverse outcomes (hemorrhage, bile leak, liver failure, wound infection other infectious complications). (clinicaltrials.gov)
  • Long-term survival and disease recurrence following portal vein embolisation prior to major hepatectomy for colorectal metastases. (nih.gov)
  • Portal vein embolisation (PVE) can be used to increase the remnant liver parenchyma volume before major hepatectomy but may stimulate tumour growth. (nih.gov)
  • Two hundred thirty-one patients met the inclusion criteria and major hepatectomy was performed in 45.5% of patients. (ovid.com)
  • Factors associated with readmission on univariate analysis included increased operative time (P = .007), major hepatectomy (P = .012), hemi or extended hepatectomy (P = .032), second stage operation (P = .031), bile leak (P = 0.022), and any complication/modified Accordion complication ≥ 3 within 30 days (P (ovid.com)
  • Takahara T, Wakabayashi G, Konno H et al (2016) Comparison of laparoscopic major hepatectomy with propensity score matched open cases from the National Clinical Database in Japan. (springer.com)
  • Published techniques for laparoscopic major hepatectomy generally involve hilar dissection with separate transection of vasculo-biliary elements and anatomical parenchymal transection along the demarcation line. (websurg.com)
  • The purpose of this study is to determine whether preoperative immunonutrition is effective on infectious complication and Th1/Th2 differentiation in patients with major hepatectomy. (checkorphan.org)
  • METHODS: Patients receiving major hepatectomy with BDR between 2000 and 2017 were retrospectively reviewed. (minervamedica.it)
  • Moreover, high ICG-R15 (≥11.8%) was an independent factor for predicting severe complications after major hepatectomy with BDR. (minervamedica.it)
  • Kuboki S, Furukawa K, Takayashiki T, Takano S, Miyazaki M, Ohtsuka M. Clinical implication of ICG test in major hepatectomy for biliary tract cancer. (minervamedica.it)
  • A standard definition of major hepatectomy: resection of four or more liver segments. (semanticscholar.org)
  • Hepatic insufficiency and mortality in 1,059 noncirrhotic patients undergoing major hepatectomy. (semanticscholar.org)
  • To assess the clinical application and usefulness of the liver hanging maneuver (LHM), proposed by Belghiti, for major hepatectomy, including its (1) historical development, (2) usefulness and application and (3) advantages and disadvantages, by reviewing the English literature published during the period 2001-2014. (semanticscholar.org)
  • Patients undergoing major hepatectomy for adult living donor transplantation in the same time period served as a control group. (readbyqxmd.com)
  • Variation in Drain Management Among Patients Undergoing Major Hepatectomy . (wroc.pl)
  • It is also a problem, to a lesser degree, in patients with previous hepatectomies (e.g. repeat resections for reincident colorectal cancer metastases). (wikipedia.org)
  • Adam R, Bismuth H, Castaing D et al (1997) Repeat hepatectomy for colorectal liver metastases. (springer.com)
  • Is Enhanced One-Stage Hepatectomy a Safe and Feasible Alternative to the Two-Stage Hepatectomy in the Setting of Multiple Bilobar Colorectal Liver Metastases? (bioportfolio.com)
  • Two-stage hepatectomy (TSH) is the present standard for multiple bilobar colorectal metastases (CLM). (bioportfolio.com)
  • Hepatectomy is used to remove benign or malignant neoplasm (abnormal tissue growth) in the liver, malignant neoplasms commonly being metastases of colorectal cancers. (sciencephoto.com)
  • Disease-free and overall survival was compared with a control group (65 patients) undergoing extended right/right hepatectomy for CRC metastases without PVE during the same time period. (nih.gov)
  • Angiogenesis inhibitor TNP-470 prevents implanted liver metastases after partial hepatectomy in an experimental model without impairing wound healing. (nih.gov)
  • Background: The impact of chemotherapy-associated liver injury (CALI) on postoperative outcome in patients undergoing partial hepatectomy for colorectal liver metastases (CRLM) remains controversial. (eur.nl)
  • Although recurrence after hepatectomy for colorectal liver metastases (CRLM) is common, the optimal treatment strategy remains unclear. (springermedizin.de)
  • Can we improve the morbidity and mortality associated with the associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) procedure in the management of colorectal liver metastases? (elsevier.com)
  • From 2001 to 2015, 119 consecutive patients who received multidisciplinary treatments based on curative gastrectomy and local treatments (hepatectomy, RFA and TACE) for liver metastases were enrolled in this retrospective cohort study. (oncotarget.com)
  • Associating Liver Partition with Portal vein ligation for Staged hepatectomy (ALPPS) versus Two-Stage Hepatectomy (TSH) for marginally resectable colorectal liver metastases - a multicentric, randomized controlled trial. (alpps.net)
  • With the broadening indications for hepatectomy to treat colorectal liver metastases (CRLM), early recurrence is a major problem. (elsevier.com)
  • This retrospective study compares outcomes after liver resection for bilobar CRC metastases between patients who underwent parenchyma-sparing hepatectomy (PSH), i.e., segmentectomies and smaller resections on both lobes, and those treated with non- PSH, i.e., hemihepatectomy plus any resection on the other lobe. (annalsgastro.gr)
  • Background Proctectomy after hepatectomy, or the reverse approach, is an alternative to traditional sequencing for advanced liver metastases with asymptomatic colorectal primary tumors. (edu.lb)
  • Most hepatectomies are performed for the treatment of hepatic neoplasms, both benign or malignant. (wikipedia.org)
  • All procedure for these eight patients with caudate hepatic tumors (size: 0.9-4.5 cm) were completed with totally laparoscopic technique except one which additional left hepatectomy was also done. (sages.org)
  • Our experience demonstrated that laparoscopic hepatectomy is a safe and feasible procedure for caudate hepatic tumors in selected patients with tumor smaller than 6 cm in non cirrhotic liver. (sages.org)
  • Methods: NTs and their receptors were investigated by RT-PCR and immunostaining in regenerating livers after two-thirds hepatectomy (PH) and in hepatocytes and hepatic stellate cells (HSCs) isolated from regenerating livers in mice. (scienceblog.com)
  • To determine if decreased hepatic PC/PE could predict survival after hepatectomy, we used mouse models lacking key enzymes in PC biosynthesis, namely, phosphatidylethanolamine N-methyltransferase and hepatic-specific CTP:phosphocholine cytidylyltransferase α. (nih.gov)
  • Decreased hepatic PC/PE before surgery was also strongly associated with decreased rates of survival after partial hepatectomy. (nih.gov)
  • Choline supplementation to the diet increased hepatic PC/PE in Pemt(-/-) mice with NAFLD, decreased inflammation, and increased the survival rate after partial hepatectomy. (nih.gov)
  • Decreased hepatic PC/PE is a predictor of NAFLD and survival following partial hepatectomy. (nih.gov)
  • One is the so-called controlled hepatectomy method and the other is approaching the right Glissonean pedicle in the liver after hepatic dissection. (springer.com)
  • however, Foster and Berman mentioned in their book entitled Solid Liver Tumors that Honjo in Japan performed anatomical right hepatectomy in 1949, which involved dividing the right hepatic artery, right portal vein and right hepatic duct at the hepatic hilus [ 3 , 4 ]. (springer.com)
  • The evidence that IGFBP-1 is a liver-specific immediate-early gene highly induced after 70% partial hepatectomy (PHx) suggests a role for the IGF-IGFBP system in hepatic regeneration. (physiology.org)
  • Liver regeneration after partial hepatectomy (PHx) has been used as a model in experimental animals to study the response of the hepatic IGF-IGFBP system to internal changes and to investigate the possible role of IGFs and IGFBPs in the regeneration process. (physiology.org)
  • 1. Thyroparathyroidectomy (TPTX) carried out at 72 h before partial hepatectomy (PH) reduced the induction of hepatic thymidylate synthetase (TS) and thymidine kinase (TK), which are rate-determining enzymes in DNA synthesis, at 24 h after PH. (clinsci.org)
  • Hepatic expression of A20 in BALB/c mice dramatically improves survival following extended and radical lethal hepatectomy. (garvan.org.au)
  • Massive hepatectomy often induced lethal hepatic failure. (nii.ac.jp)
  • We concluded that fatal hepatic after excessive hepatectomy was characterized by increased apoptosis and diminished liver regeneration. (nii.ac.jp)
  • In major hepatic transection via the anterior approach, the deep area of transection around the vena cava is critical with regard to bleeding during right hemi-hepatectomy. (semanticscholar.org)
  • Pawlik, Timothy M. / Patterns of care among patients undergoing hepatic resection : A query of the National Surgical Quality Improvement Program-targeted hepatectomy database . (elsevier.com)
  • Ninety-seven patients who underwent partial hepatectomy for HCC had their CVP controlled at a level of 0 to 5 mmHg during hepatic parenchymal transection. (qxmd.com)
  • Researchers from the Center for Applied Medical Research (CIMA) discovered that CT-I is able to stimulate hepatic regeneration after partial hepatectomy , as well as to defend the liver against warm ischemia reperfusion injury. (thefreedictionary.com)
  • Hepatectomies are performed to surgically remove tumors from the liver. (encyclopedia.com)
  • It is appropriate for patients undergoing a hepatectomy for primary and secondary tumors of the liver. (mskcc.org)
  • Compare the surgical techniques in open, laparoscopic, and robotic assisted hepatectomy for resection of liver tumors. (scielo.br)
  • This study included 110 consecutive patients undergoing partial hepatectomy for solitary liver tumors (59 had OH and 51 had LH). (springer.com)
  • Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized study. (qxmd.com)
  • Partial hepatectomy did not affect the yields of lung tumors, liver hemangiomas, or the number and character of skin tumors if ethyl carbamate was followed by a promoting treatment with croton oil. (edu.au)
  • Methods: The investigators will complete a randomized controlled trial evaluating the incidence of postoperative complications and overall hospital length of stay in adult patients following preoperative vs. no administration of 500 mg of methylprednisolone (MP) within 30 minutes of starting a hepatectomy. (clinicaltrials.gov)
  • Hypothesis: Preoperative GC administration will decrease the incidence of postoperative complications and overall hospital length of stay following hepatectomy. (clinicaltrials.gov)
  • We then performed a 70% partial hepatectomy and monitored postoperative survival. (nih.gov)
  • The investigators reported that preoperative immunonutrition improve the incidence of postoperative infectious complication in patients after hepatectomy, and modulation of Th1/Th2 differentiation may play important roles in this effect. (checkorphan.org)
  • Object of this study is to investigate the effects of preoperative immunonutrition on incidence of postoperative infectious complication, and Th1/Th2 balance after hepatectomy. (checkorphan.org)
  • The aim of this study was to evaluate whether indocyanine green retention rate after 15 minutes of injection (ICG-R15) is useful for predicting the risk of severe postoperative complications in this operation, and to reveal the mechanisms of increasing severe complications by focusing on immune function and liver regeneration after hepatectomy. (minervamedica.it)
  • Conclusion: An increase in postoperative major morbidity and liver surgery-specific complications was observed after partial hepatectomy in patients with severe SD and steatohepatitis. (eur.nl)
  • We strongly recommend early postoperative mobilization and antithrombotic prophylaxis on all patients undergoing donor hepatectomies. (clinmedjournals.org)
  • But the routine abdominal drainage after donor hepatectomy is questioned as the drain increases the postoperative discomfort and also it hampers early ambulation of donor in postoperative period. (atcmeetingabstracts.com)
  • This study aims to investigate the protective effects and underlying mechanisms of hydrogen-rich saline on the cognitive functions of elder mice with partial hepatectomy-induced postoperative cognitive dysfunction (POCD). (molecularhydrogenstudies.com)
  • Effects of hydrogen-rich saline on hepatectomy-induced postoperative cognitive dysfunction in old mice. (molecularhydrogenstudies.com)
  • The hepatectomy results are analyzed with the aim of further reducing the postoperative morbidity rate. (hku.hk)
  • Maintaining a low central venous pressure during living donor hepatectomy is routine practice. (bioportfolio.com)
  • Background: Open living donor hepatectomy (OLDH) is a highly painful procedure. (authorea.com)
  • Readmission and Reoperation After Living Donor Hepatectomy. (atcmeetingabstracts.com)
  • Analysis of Reoperation and Readmission rates following Living Donor Hepatectomy from a single center from Western India. (atcmeetingabstracts.com)
  • Retrospective analysis of records of living donors who required re-exploration and / or readmissions after Living donor hepatectomy performed between April 2013 & October 2016 at a single center. (atcmeetingabstracts.com)
  • In experienced centers, living donor hepatectomy can be performed with zero mortality and low complications. (atcmeetingabstracts.com)
  • Omega-3 polyunsaturated fatty acids promote liver regeneration after 90% hepatectomy in rats. (biomedsearch.com)
  • AIM: To evaluate the effectiveness of omega-3 polyunsaturated fatty acid (ω-3 PUFA) administration on liver regeneration after 90% partial hepatectomy (PH) in rats. (biomedsearch.com)
  • The ability of the angiogenesis inhibitor TNP-470 to prevent liver metastasis after partial hepatectomy, and whether TNP-470 impairs liver regeneration or skin wound healing, was evaluated. (nih.gov)
  • Intraportal infusion of TNP-470 prevents the recurrence of liver metastasis after partial hepatectomy without impairing healing or liver regeneration. (nih.gov)
  • Moris D, Vernadakis S, Papalampros A, Vailas M, Dimitrokallis N, Petrou A, Dimitroulis D. Mechanistic insights of rapid liver regeneration after associating liver partition and portal vein ligation for stage hepatectomy. (wjgnet.com)
  • We investigated the roles of SMO+ myofibroblast (MF) in liver regeneration by conditional deletion of SMO in α smooth muscle actin (αSMA)+ cells after partial hepatectomy (PH). (bmj.com)
  • Methods : We applied large-scale gene expression analysis with complementary DNA (cDNA) microarrays in mouse hepatectomy models to clarify the mechanism of liver regeneration after partial hepatectomy. (nii.ac.jp)
  • Mechanism of liver regeneration after partial hepatectomy using mouse cDNA microarray'J Hepatology. (nii.ac.jp)
  • The aim of this study w as to determine whether the K_{ATP} channel opener minoxidil accelerates liver regeneration after partial hepatectomy (PH) in vivo. (iospress.com)
  • In this case, the transplant surgeon performs a total hepatectomy, meaning that the patient's entire liver is removed, and it is replaced with a healthy liver from a donor. (encyclopedia.com)
  • Partial hepatectomies are also performed to remove a portion of a liver from a live donor for transplantation. (wikipedia.org)
  • Experience of 1194 Virtual Hepatectomy Before Liver Resection and Living Donor Liver Transplantation. (springer.com)
  • Laparoscopic Live Donor Hepatectomy: Random Mutation or Stepwise Evolution? (wiley.com)
  • 2020) Thromboelastogram Demonstrates Significant Hypercoagulability in Patients Undergoing Right Donor Hepatectomy - A Prospective Single-Center Analysis. (clinmedjournals.org)
  • 80 consecutive patients who underwent right donor hepatectomies were enrolled in the study. (clinmedjournals.org)
  • Despite routine laboratory investigations suggesting hypocoagulability, TEG monitoring showed significant hypercoagulability in all the patients who underwent right donor hepatectomies. (clinmedjournals.org)
  • Are Drains Required After Donor Hepatectomy? (atcmeetingabstracts.com)
  • Abdominal drainage after donor hepatectomy is a routine practice in most of the LDLT centres. (atcmeetingabstracts.com)
  • Conclusion: Abdominal drain placement in donor hepatectomy should be individualised. (atcmeetingabstracts.com)
  • Coagulation profiles following donor hepatectomy and implications for the risk of epidural hematoma associated with epidural anesthesia. (thefreedictionary.com)
  • There is an isolated report of acquired diaphragmatic herniation complicating donor hepatectomy [5], as was the case here. (thefreedictionary.com)
  • 137 Donor hepatectomies were done during this period (121 Right Liver grafts and 16 Left lobe and Left lateral segment grafts). (atcmeetingabstracts.com)
  • Hepatectomy is the surgical resection (removal of all or part) of the liver. (wikipedia.org)
  • A partial hepatectomy is the surgical removal of the part of the liver affected by cancer. (cancercare.org)
  • Refinement of surgical interventions, perioperative management, and earlier diagnosis in liver surgery over recent decades have resulted in marked improvement of long-term survival for HCC patients undergoing hepatectomy. (hindawi.com)
  • Excision of tissue during a hepatectomy (surgical resection of the liver). (sciencephoto.com)
  • Although VH did not significantly influenced on the long-term outcome after hepatectomy, a more parenchymal-sparing operative procedure (anatomical resections, plus limited resections) was selected and the risk of a submillimeter surgical margin was reduced after introduction of VH. (springer.com)
  • Several factors have made hepatectomy an increasingly safe surgery and new drugs allowed surgical treatment for patients who initially were not candidates for resection. (scielo.br)
  • the number of complete surgical procedure is defined as the number of patients in whom the two stage hepatectomy is complete. (knowcancer.com)
  • Despite the recent improvements in surgical techniques and devices, hepatectomy-related surgical site infections (SSIs) account for about 1/3 of the nosocomial infections ( 2 , 3 ). (frontiersin.org)
  • Surgical treatment has always been the major treatment method for liver cancer, but the residual liver volume after hepatectomy is insufficient to maintain normal liver function due to the late detection of liver cancer in certain patients or due to the presence of a large liver tumor. (spandidos-publications.com)
  • Partial hepatectomy (PHx) is a surgical intervention where a part of the liver is removed. (arxiv.org)
  • Hepatectomy is the optimal local treatment for GCLM when surgical R0 resection is intended. (oncotarget.com)
  • Preoperative determination of the surgical procedure for hepatectomy using technetium-99m-galactosyl human serum albumin ([sup. (thefreedictionary.com)
  • The surgical plan was an extended right hepatectomy, resection of segments I, V, VI, VII, & VIII with a Whipple and right nephrectomy. (utoronto.ca)
  • At Queen Mary Hospital, Hong Kong, the surgical techniques and perioperative management in hepatectomy for HCC have evolved yearly into a final standardized protocol that reduced the hospital mortality rate from 28% in 1989 to 0% in 1996 and 1997. (hku.hk)
  • Methods: Surgical techniques were designed to reduce intraoperative blood loss, blood transfusion, and ischemic injury to the liver remnant in hepatectomy. (hku.hk)
  • Conclusion: With appropriate surgical techniques and perioperative management to preserve function of the liver remnant, hepatectomy for HCC can be performed without hospital deaths. (hku.hk)
  • A laparoscopic right hepatectomy was scheduled, but due to unexpected tumor extension during surgical exploration and the need for a larger than planned liver resection, a pure laparoscopic ALPPS approach was performed. (sls.org)
  • From 2007 to 2017, a total of 473 CRLM patients who received curative hepatectomy were retrospectively assessed. (springer.com)
  • Open hepatectomy was performed on 68 patients with cirrhosis from January 2010 to May 2017. (springermedizin.at)
  • Is there a need for an extrahepatic organ resection during the hepatectomy? (mskcc.org)
  • A novel 3D hepatectomy simulation based on liver circulation: application to liver resection and transplantation. (springer.com)
  • Lesions often require resection, which can be performed by open, laparoscopic, or robotic assisted hepatectomy. (scielo.br)
  • The purpose of this study is to determine whether diaphragm resection during partial hepatectomy for metastatic colorectal cancer influences short-term perioperative outcomes and overall survival. (semanticscholar.org)
  • Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has recently been introduced as a feasible strategy that allows complete resection with curative intention in selected patients with otherwise locally unresectable disease due to an insufficient future liver remnant. (sls.org)
  • 1] However, it is essential to accurately diagnose Caroli's disease since partial hepatectomy can be curative if the disease is confined to a lobe. (thefreedictionary.com)
  • Operative morbidity and mortality rates of repeat hepatectomy were 29 and 0 %, respectively. (springer.com)
  • However, surgery is likely to increase complications or risk of mortality, which limits the use of hepatectomy ( 5 , 6 ). (spandidos-publications.com)
  • Multivariate analysis was performed to identify independent predictors of in-hospital mortality after hepatectomy. (eur.nl)
  • In multivariate analyses, a high CONUT score was an independent predictor of in-hospital mortality after hepatectomy (hazard ratio [HR] 9.41, p = 0.038), but the PNI was not (HR 5.86, p = 0.08). (eur.nl)
  • Background Meticulous selection of patients who can undergo the associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) procedure safely will be paramount to minimize the associated morbidity and mortality. (elsevier.com)
  • Conclusions: Despite the more frequent occurrence of complications with a Clavien-Dindo grade of 3a or higher among the elderly patients undergoing hepatectomy for HCC, their mortality and recurrence rates were comparable with those of the nonelderly patients. (elsevier.com)
  • Conclusions: Hepatectomy patients meeting BL criteria have an overall post-hepatectomy mortality rate that is triple that of non-BL patients. (elsevier.com)
  • In total, 30.4% and 69.6% of patients were treated by major and minor hepatectomy, respectively, with in-hospital mortality rates of 5.6% and 1.4%, respectively. (medwirenews.com)
  • Total hepatectomy (THx) and OLT were performed when tumor extension or the presence of underlying liver disease precluded PHx. (pubmedcentralcanada.ca)
  • After multidisciplinary evaluation in our Institutional tumor board the patient was scheduled for left hepatectomy with robotic approach. (ilts.org)
  • Mobilization of the right liver is sometimes difficult and unsafe in right hepatectomy for a huge tumor due to massive bleeding or iatrogenic tumor rupture. (springer.com)
  • Hepatectomy is the removal of liver around 50-85% part of the liver due to liver dysfunctioning, presence of a tumor, cirrhosis, etc. (practo.com)
  • Hepatectomy for Tumor is a topic covered in the Pediatric Surgery NaT . (pedsurglibrary.com)
  • APSA Webapp , www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829235/all/Hepatectomy_for_Tumor. (pedsurglibrary.com)
  • The researchers performed a retrospective analysis on 408 HCC patients with a tumor status within the Milan criteria who underwent partial hepatectomy at a single center during 1995-2008. (medwirenews.com)
  • This study sought to clarify the survival benefit for patients undergoing repeat hepatectomy for gastric cancer liver metastasis. (springer.com)
  • A total of 73 patients underwent hepatectomy for gastric cancer liver metastasis from January 1993 to January 2011. (springer.com)
  • In selected patients, repeat hepatectomy for recurrent gastric cancer liver metastasis may offer the same chance of cure as the primary hepatectomy. (springer.com)
  • In case of bilobar metastasis, classic two-stage hepatectomy with portal embolization could be performed. (knowcancer.com)
  • The aim of the present study was to investigate the application of propofol combined with sevoflurane anesthesia in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). (spandidos-publications.com)
  • Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an effective method for the treatment of patients with liver cancer who cannot undergo hepatectomy and may promote short-term rapid proliferation of residual liver cells after surgery ( 8 , 9 ). (spandidos-publications.com)
  • Associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) combines PVL and complete parenchymal transection, followed by hepatectomy within 1-2 weeks. (uzh.ch)
  • Background Publications using the ALPPS (associating liver partition and portal vein ligation for a staged hepatectomy) procedure have demonstrated a future liver remnant growth of 40-160% in only 6-9 days. (elsevier.com)
  • Nagorney, David M. / Characterization of a porcine model for associating liver partition and portal vein ligation for a staged hepatectomy . (elsevier.com)
  • A hepatectomy is considered a major surgery done under general anesthesia. (wikipedia.org)
  • Our liver cancer nomogram is a tool designed to predict the likelihood of requiring a transfusion of red blood cells before, during, or shortly after a hepatectomy (surgery to remove part or all of the liver) for liver cancer. (mskcc.org)
  • How Has Virtual Hepatectomy Changed the Practice of Liver Surgery? (springer.com)
  • Despite all challenges, laparoscopic hepatectomy presents many benefits over open surgery. (scielo.br)
  • There were no conversions to open surgery in the laparoscopic hepatectomy group. (springermedizin.at)
  • An alternative to the classic surgery, early two stage hepatectomy, could be proposed to simplify the patient's management and to improve the resectability. (knowcancer.com)
  • Background: In open surgery for major hepatectomies, the Glissonian approach and liver hanging maneuver have proven useful. (websurg.com)
  • A multivariate analysis revealed that a primary N-negative status [relative risk (RR) 2.93, P = 0.017], indocyanine retention rate at 15 min ≤ 10% before hepatectomy (RR 2.49, P = 0.04), and carcinoembryonic antigen ≤ 5 ng/mL before hepatectomy (RR 2.96, P = 0.017) independently predicted the performance of repeat surgery. (springermedizin.de)
  • A certified and trained General Surgeon, Gastroenterologist and a Hepatologist who is well experienced in Hepatectomy can perform this surgery. (practo.com)
  • Surgery to remove part of the liver is called partial hepatectomy . (cancer.org)
  • At surgery the following day, the supra- and sub-diaphragmatic vascular mass was excised, and a partial left hepatectomy was performed. (thefreedictionary.com)
  • However, as ALPPS is complex and the operation time is longer than that of common hepatectomy, the anesthesia requirements for ALPPS are high, which limits the use of numerous anesthetic methods and anesthetics. (spandidos-publications.com)
  • METHODS: Male Wistar rats subjected to 70% partial hepatectomy were divided into five groups (groups 1-5). (edu.mx)
  • METHODS: A retrospective review of all patients undergoing ALPPS or conventional staged hepatectomies using PVL or PVE at four high-volume HPB centres between 2003 and 2012 was performed. (uzh.ch)
  • Methods A total of 13 female domestic pigs underwent ALPPS stage 1 (portal vein division and parenchymal transection) followed by ALPPS stage 2 (completion left-extended hepatectomy) 7 days later. (elsevier.com)
  • Methods: A single-center, retrospective cohort study was conducted with 104 patients who underwent hepatectomy for HCC from 2005 to 2010. (elsevier.com)
  • A prospective randomized controlled trial: comparison of two different methods of hepatectomy. (qxmd.com)
  • Methods A single-institution colorectal database was queried for patients treated with proctectomy after previous hepatectomy from 2003 to 2011. (edu.lb)
  • Methods: All elective hepatectomies were identified in the 2005-2013 ACS-NSQIP database. (elsevier.com)
  • Hepatectomy may also be the procedure of choice to treat intrahepatic gallstones or parasitic cysts of the liver. (wikipedia.org)
  • Single incision partial hepatectomy is a new procedure than can be considered in appropriate candidates. (sages.org)
  • Partial hepatectomy (PHx) was the procedure of choice. (pubmedcentralcanada.ca)
  • Bismuth [ 1 ] combined these two procedures into his own right hepatectomy procedure. (springer.com)
  • Robotic Left Hepatectomy for HCC on. (ilts.org)
  • Consecutive patients undergoing hepatectomy by a single surgeon 2012-2016 were identified in a prospectively maintained database. (ovid.com)
  • Results: Of 330 patients undergoing hepatectomy for HCC, underlying cirrhosis and chronic hepatitis were present in 161 (49%) and 108 (33%) patients, respectively. (hku.hk)
  • When a subtotal hepatectomy could not be performed, total hepatectomy (THx) with liver transplantation was a valuable option. (nih.gov)
  • Effects of clinoptilolite treatment on oxidative stress after partial hepatectomy in rats. (thefreedictionary.com)
  • Reducing post-hepatectomy complications are crucial to this end. (clinicaltrials.gov)
  • Hepatectomy in patients with liver cirrhosis is associated with a higher rate of complications. (springermedizin.at)
  • Are two-stage hepatectomies associated with more complications than one-stage procedures? (uzh.ch)
  • Half clamping of the infrahepatic inferior vena cava reduces bleeding during a hepatectomy by decreasing the central venous pressure. (qxmd.com)
  • The aim of this study was to evaluated the advantages of routine application of the anterior approach in patients scheduled to right hepatectomy or extended right hepatectomy, without infiltration of segment 1, inferior vena cava or main bile duct. (careacross.com)
  • This video demonstrates the feasibility of the Glissonian approach and liver hanging maneuver that were performed for total laparoscopic right hepatectomy. (websurg.com)
  • A total laparoscopic right hepatectomy was performed for this lesion. (websurg.com)
  • Conclusions Glissonian approach and hanging maneuver have proven to be safe and useful procedures for performing precise laparoscopic right hepatectomy. (websurg.com)
  • Encapsulated Whole Bone Marrow Cells Improve Survival in Wistar Rats after 90% Partial Hepatectomy," Stem Cells International , vol. 2016, Article ID 4831524, 9 pages, 2016. (hindawi.com)
  • RESULTS: All rats in the control group died within 30 h after hepatectomy. (biomedsearch.com)
  • Long Evans rats were subjected to either partial hepatectomy (PH) or sham operation (SH) and were treated with liver cytosol (C) and cyclosporine (Cy). (journals.co.za)
  • Male Wistar rats underwent a 70% partial hepatectomy (PH) after receiving a subcutaneous injection of minoxidil (0.01 mg/kg or 0.03 mg/kg). (iospress.com)
  • Follow-up studies are available from 1 year to 27 years, after 41 patients with FL-HCC were treated with partial hepatectomy (PHx) (28 patients) or liver transplantation (13 patients). (nih.gov)
  • The data indicate that a significant portion of patients with HCC eligible for liver transplantation can be treated effectively by hepatectomy," say Sheung Fan (University of Hong Kong, China) and co-authors. (medwirenews.com)
  • In present study, we conducted a meta-analysis to clarify the survival benefits and safety of hepatectomy versus TACE in HCC patients with MaVI. (jcancer.org)
  • This study was conducted to investigate the clinical effectand safety of hepatectomy combining with 'Jianpi Huayu Therapy' in the treatment of HCC. (waocp.org)
  • Mobilization of the liver during right hepatectomy with classic approach is performed before parenchymal transection. (careacross.com)
  • A retrospective analysis was performed on 121 consecutive patients who underwent hepatectomy for CRLM. (elsevier.com)
  • Results: A consolidated database comprising 788 patients who underwent hepatectomy for CRLM in eight centres was obtained. (eur.nl)
  • The propensity model revealed that hepatectomy was associated with significantly longer OS compared with either or both RFA and TACE (P=0.021). (oncotarget.com)
  • Hepatectomy combinedwith 'Jianpi Huayu therapy'was effective in the treatment of HCC, and reduced post-operative recurrence andmetastasis and improved DFS and OS of HCC patients. (waocp.org)
  • We conduct a randomised controlled trial evaluating the efficacy of using TACE after hepatectomy in HCC patients. (clinicaltrials.gov)
  • The overall survival (OS) is higher in hepatectomy group than TACE group (HR=1.61, 95%CI=1.23-2.10, p =0.0005). (jcancer.org)
  • Subgroup analysis demonstrated that hepatectomy was superior over TACE for patients with PVTT (HR=1.50, 95%CI=1.14-1.98, p =0.004), but not for patients with HVTT/IVC (HR=2.39, 95%CI=0.88-6.49, p =0.09). (jcancer.org)
  • Our results indicated that, compared to TACE, hepatectomy might be a better treatment option for resectable HCC patients with MaVI. (jcancer.org)
  • This study aimed to evaluate the efficacy of hepatectomy, RFA and TACE as local treatments for GCLM. (oncotarget.com)
  • Patients were divided into Group A (46, hepatectomy) and Group B (73, either or both RFA and TACE). (oncotarget.com)
  • and 85.4%, 21.9% and 12.2%, respectively in Group B. Subgroup analyses indicated that hepatectomy was associated with significantly longer long-term survival compared with TACE (P=0.033) and RFA (P=0.010). (oncotarget.com)
  • RESULTS: Forty-eight patients with ALPPS were compared with 83 patients with conventional-staged hepatectomies. (uzh.ch)
  • All 14 ALPPS patients completed the 2-stage hepatectomy. (elsevier.com)
  • With less clinical reserve, BL patients who suffer SC are at greater risk of post-hepatectomy death. (elsevier.com)
  • Less intraoperative blood loss is frequently reported as an advantage of laparoscopic hepatectomy (LH) over open hepatectomy (OH). (springer.com)
  • As alternative, ultrasound-guided one-stage hepatectomy (E-OSH) has been proposed even for deep-lo. (bioportfolio.com)