Urinary Bladder: A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Heparin, Low-Molecular-Weight: Heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective antithrombotic agents. Their administration reduces the risk of hemorrhage, they have a longer half-life, and their platelet interactions are reduced in comparison to unfractionated heparin. They also provide an effective prophylaxis against postoperative major pulmonary embolism.Urinary Bladder Diseases: Pathological processes of the URINARY BLADDER.Heparin Antagonists: Coagulant substances inhibiting the anticoagulant action of heparin.Heparin Lyase: An enzyme of the isomerase class that catalyzes the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. (From Enzyme Nomenclature, 1992) EC 18.104.22.168.Urinary Bladder, Overactive: Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. URINARY INCONTINENCE may or may not be present.Heparin Cofactor II: A sulfated plasma protein with a MW of approximately 66kDa that resembles ANTITHROMBIN III. The protein is an inhibitor of thrombin in plasma and is activated by dermatan sulfate or heparin. It is a member of the serpin superfamily.Urinary Bladder, Neurogenic: Dysfunction of the URINARY BLADDER due to disease of the central or peripheral nervous system pathways involved in the control of URINATION. This is often associated with SPINAL CORD DISEASES, but may also be caused by BRAIN DISEASES or PERIPHERAL NERVE DISEASES.Urinary Bladder Neck Obstruction: Blocked urine flow through the bladder neck, the narrow internal urethral opening at the base of the URINARY BLADDER. Narrowing or strictures of the URETHRA can be congenital or acquired. It is often observed in males with enlarged PROSTATE glands.Anticoagulants: Agents that prevent clotting.Urinary Bladder Calculi: Stones in the URINARY BLADDER; also known as vesical calculi, bladder stones, or cystoliths.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Antithrombin III: A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.Urothelium: The epithelial lining of the URINARY TRACT.Antithrombins: Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.Bladder Exstrophy: A birth defect in which the URINARY BLADDER is malformed and exposed, inside out, and protruded through the ABDOMINAL WALL. It is caused by closure defects involving the top front surface of the bladder, as well as the lower abdominal wall; SKIN; MUSCLES; and the pubic bone.Cystitis: Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.Cystoscopy: Endoscopic examination, therapy or surgery of the urinary bladder.Urination: Discharge of URINE, liquid waste processed by the KIDNEY, from the body.Administration, Intravesical: The instillation or other administration of drugs into the bladder, usually to treat local disease, including neoplasms.Partial Thromboplastin Time: The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.Glycosaminoglycans: Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.Cystectomy: Used for excision of the urinary bladder.Enoxaparin: Low-molecular-weight fragment of heparin, having a 4-enopyranosuronate sodium structure at the non-reducing end of the chain. It is prepared by depolymerization of the benzylic ester of porcine mucosal heparin. Therapeutically, it is used as an antithrombotic agent. (From Merck Index, 11th ed)Urodynamics: The mechanical laws of fluid dynamics as they apply to urine transport.Whole Blood Coagulation Time: The time required by whole blood to produce a visible clot.Protamines: A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)Dalteparin: A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed)Dermatan Sulfate: A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)Factor Xa: Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.Platelet Factor 4: A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.Hirudins: Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.Cystitis, Interstitial: A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.Thrombin: An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.Fibrinolytic Agents: Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.Blood Coagulation: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.Urethra: A tube that transports URINE from the URINARY BLADDER to the outside of the body in both the sexes. It also has a reproductive function in the male by providing a passage for SPERM.Polysaccharide-Lyases: A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in polysaccharides leading to an unsaturated product and the elimination of an alcohol. EC 4.2.2.Hemorrhage: Bleeding or escape of blood from a vessel.Urinary Catheterization: Passage of a CATHETER into the URINARY BLADDER or kidney.Muscle, Smooth: Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)Thrombophlebitis: Inflammation of a vein associated with a blood clot (THROMBUS).Chromatography, Affinity: A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Chondroitin Sulfates: Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.Blood Coagulation Tests: Laboratory tests for evaluating the individual's clotting mechanism.Heparinoids: Heparin derivatives. The term has also been used more loosely to include naturally occurring and synthetic highly-sulphated polysaccharides of similar structure. Heparinoid preparations have been used for a wide range of applications including as anticoagulants and anti-inflammatories and they have been claimed to have hypolipidemic properties. (From Martindale, The Extra Pharmacopoeia, 30th, p232)Hirudin Therapy: Use of HIRUDINS as an anticoagulant in the treatment of cardiological and hematological disorders.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Kinetics: The rate dynamics in chemical or physical systems.Pentosan Sulfuric Polyester: A sulfated pentosyl polysaccharide with heparin-like properties.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Urinary Bladder Fistula: An abnormal passage in the URINARY BLADDER or between the bladder and any surrounding organ.Disaccharides: Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Thrombin Time: Clotting time of PLASMA mixed with a THROMBIN solution. It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. BATROXOBIN, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Urinary Retention: Inability to empty the URINARY BLADDER with voiding (URINATION).Hematuria: Presence of blood in the urine.Thrombocytopenia: A subnormal level of BLOOD PLATELETS.Thromboembolism: Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.Urinary Diversion: Temporary or permanent diversion of the flow of urine through the ureter away from the URINARY BLADDER in the presence of a bladder disease or after cystectomy. There is a variety of techniques: direct anastomosis of ureter and bowel, cutaneous ureterostomy, ileal, jejunal or colon conduit, ureterosigmoidostomy, etc. (From Campbell's Urology, 6th ed, p2654)Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Urologic Surgical Procedures: Surgery performed on the urinary tract or its parts in the male or female. For surgery of the male genitalia, UROLOGIC SURGICAL PROCEDURES, MALE is available.Urinary Tract: The duct which coveys URINE from the pelvis of the KIDNEY through the URETERS, BLADDER, and URETHRA.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Venous Thrombosis: The formation or presence of a blood clot (THROMBUS) within a vein.Urinary Incontinence: Involuntary loss of URINE, such as leaking of urine. It is a symptom of various underlying pathological processes. Major types of incontinence include URINARY URGE INCONTINENCE and URINARY STRESS INCONTINENCE.Muscarinic Antagonists: Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.Gallbladder Emptying: A process whereby bile is delivered from the gallbladder into the duodenum. The emptying is caused by both contraction of the gallbladder and relaxation of the sphincter mechanism at the choledochal terminus.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).PolysaccharidesSulfates: Inorganic salts of sulfuric acid.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Mucous Membrane: An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.Hypogastric Plexus: A complex network of nerve fibers in the pelvic region. The hypogastric plexus distributes sympathetic fibers from the lumbar paravertebral ganglia and the aortic plexus, parasympathetic fibers from the pelvic nerve, and visceral afferents. The bilateral pelvic plexus is in its lateral extent.Pulmonary Embolism: Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.Urethral Obstruction: Partial or complete blockage in any part of the URETHRA that can lead to difficulty or inability to empty the URINARY BLADDER. It is characterized by an enlarged, often damaged, bladder with frequent urges to void.Aminobiphenyl Compounds: Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.Urine: Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.Bufo marinus: A species of the true toads, Bufonidae, becoming fairly common in the southern United States and almost pantropical. The secretions from the skin glands of this species are very toxic to animals.Pipecolic AcidsFibroblast Growth Factor 1: A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).Injections, Subcutaneous: Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.Phenylpropanolamine: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Molecular Weight: The sum of the weight of all the atoms in a molecule.Iduronic Acid: Component of dermatan sulfate. Differs in configuration from glucuronic acid only at the C-5 position.Epispadias: A birth defect due to malformation of the URETHRA in which the urethral opening is above its normal location. In the male, the malformed urethra generally opens on the top or the side of the PENIS, but the urethra can also be open the entire length of the penis. In the female, the malformed urethral opening is often between the CLITORIS and the labia, or in the ABDOMEN.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Antithrombin Proteins: An endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin. Six naturally occurring antithrombins have been identified and are designated by Roman numerals I to VI. Of these, Antithrombin I (see FIBRIN) and ANTITHROMBIN III appear to be of major importance.Air Sacs: Thin-walled sacs or spaces which function as a part of the respiratory system in birds, fishes, insects, and mammals.Benzidines: Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.Sulfuric Acids: Inorganic and organic derivatives of sulfuric acid (H2SO4). The salts and esters of sulfuric acid are known as SULFATES and SULFURIC ACID ESTERS respectively.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.SepharoseFANFT: A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.Ureter: One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the URINARY BLADDER.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Pelvis: The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.Fibroblast Growth Factor 2: A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Factor X: Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.Uroplakin III: A uroplakin subtype that heterodimerizes with UROPLAKIN IB to form a component of the asymmetric unit membrane found in urothelial cells.Fibrinopeptide A: Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. Each peptide chain contains 18 amino acid residues. In vivo, fibrinopeptide A is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Mandelic Acids: Analogs or derivatives of mandelic acid (alpha-hydroxybenzeneacetic acid).Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)Muscle Neoplasms: Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.Cell Line, Tumor: A cell line derived from cultured tumor cells.Lipoprotein Lipase: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 22.214.171.124.Serine Proteinase Inhibitors: Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.Drug Contamination: The presence of organisms, or any foreign material that makes a drug preparation impure.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cystostomy: Surgical creation of an opening (stoma) in the URINARY BLADDER for drainage.Flavobacterium: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in SOIL and WATER. Its organisms are also found in raw meats, MILK and other FOOD, hospital environments, and human clinical specimens. Some species are pathogenic in humans.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Recurrence: The return of a sign, symptom, or disease after a remission.Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).Uronic Acids: Acids derived from monosaccharides by the oxidation of the terminal (-CH2OH) group farthest removed from the carbonyl group to a (-COOH) group. (From Stedmans, 26th ed)Platelet Aggregation Inhibitors: Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Disseminated Intravascular Coagulation: A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.Fibrin: A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.Diagnostic Techniques, Urological: Methods and procedures for the diagnosis of diseases or dysfunction of the urinary tract or its organs or demonstration of its physiological processes.Chromatography, Gel: Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Pudendal Nerve: A nerve which originates in the sacral spinal cord (S2 to S4) and innervates the PERINEUM, the external GENITALIA, the external ANAL SPHINCTER and the external urethral sphincter. It has three major branches: the perineal nerve, inferior anal nerves, and the dorsal nerve of penis or clitoris.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Surface Plasmon Resonance: A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.CresolsBCG Vaccine: An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.Nitrous Acid: Nitrous acid (HNO2). A weak acid that exists only in solution. It can form water-soluble nitrites and stable esters. (From Merck Index, 11th ed)Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Saccharin: Flavoring agent and non-nutritive sweetener.Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.Prothrombin: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Sulfotransferases: Enzymes which transfer sulfate groups to various acceptor molecules. They are involved in posttranslational sulfation of proteins and sulfate conjugation of exogenous chemicals and bile acids. EC 2.8.2.Blood Coagulation Factors: Endogenous substances, usually proteins, that are involved in the blood coagulation process.Urinary Incontinence, Urge: Involuntary discharge of URINE that is associated with an abrupt and strong desire to void. It is usually related to the involuntary contractions of the detrusor muscle of the bladder (detrusor hyperreflexia or detrusor instability).Urologic Diseases: Pathological processes of the URINARY TRACT in both males and females.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Tissue Plasminogen Activator: A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.Urography: Radiography of any part of the urinary tract.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.Platelet Glycoprotein GPIIb-IIIa Complex: Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Rats, Inbred F344Streptokinase: Streptococcal fibrinolysin . An enzyme produced by hemolytic streptococci. It hydrolyzes amide linkages and serves as an activator of plasminogen. It is used in thrombolytic therapy and is used also in mixtures with streptodornase (STREPTODORNASE AND STREPTOKINASE). EC 3.4.-.Chymases: A family of neutral serine proteases with CHYMOTRYPSIN-like activity. Chymases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.Receptor, Muscarinic M3: A subclass of muscarinic receptor that mediates cholinergic-induced contraction in a variety of SMOOTH MUSCLES.Urology: A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Catheters, Indwelling: Catheters designed to be left within an organ or passage for an extended period of time.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Fibronectins: Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.Reflex: An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Carbohydrate Conformation: The characteristic 3-dimensional shape of a carbohydrate.Mast Cells: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.Venous Thromboembolism: Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Mast-Cell Sarcoma: A unifocal malignant tumor that consists of atypical pathological MAST CELLS without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.Hexadimethrine Bromide: A synthetic polymer which agglutinates red blood cells. It is used as a heparin antagonist.Angina, Unstable: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Chlorates: Inorganic salts of chloric acid that contain the ClO3- ion.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Receptors, Fibroblast Growth Factor: Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Cell Adhesion: Adherence of cells to surfaces or to other cells.Dextrans: A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.Arylamine N-Acetyltransferase: An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without COENZYME A and has a wide specificity for aromatic amines, including SEROTONIN. However, arylamine N-acetyltransferase should not be confused with the enzyme ARYLALKYLAMINE N-ACETYLTRANSFERASE which is also referred to as SEROTONIN ACETYLTRANSFERASE.CHO Cells: CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.Adrenergic beta-3 Receptor Agonists: Compounds that bind to and activate ADRENERGIC BETA-3 RECEPTORS.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The stent inserted has a small rare earth magnet attached to its bladder end which dangles freely within the bladder. When the ... Recently stents with coatings, such as heparin, were approved to reduce infection and encrustation to reduce the number of ... Drugs used for the treatment of OAB (over active bladder) are sometimes given to reduce or eliminate the increased urgency and ... bladder, or groin, and pain in the kidneys during, and for a short time after urination. These effects are generally temporary ...
Other agents used for bladder instillations to treat interstitial cystitis include: heparin, lidocaine, chondroitin sulfate, ... terms currently in use in addition to IC/BPS include painful bladder syndrome, bladder pain syndrome and hypersensitive bladder ... Research has shown a proliferation of nerve fibers is present in the bladders of people with IC which is absent in the bladders ... Overactive bladder Trigger point-a key to myofascial pain syndrome. "Interstitial cystitis/bladder pain syndrome fact sheet". ...
Heparin-binding EGF-like growth factor
1999). "Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower ... 1994). "Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin". J. ... Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the ... Heparin-binding EGF-like growth factor has been shown to interact with NRD1, Zinc finger and BTB domain-containing protein 16 ...
Secreted frizzled-related protein 1
Heparin is widely used as an injectable anticoagulant. SFRP1 are heparin-binding proteins, with the heparin-binding domain ... Dulaimi E, Uzzo RG, Greenberg RE, Al-Saleem T, Cairns P (March 2004). "Detection of bladder cancer in urine by a tumor ... In vitro studies show that SFRP1 is stabilizezd by heparin, suggesting that heparin or endogenous heparan-sulfate proteoglycan ... Thus, Heparin is a potential drug that could be used to stabilize and accumulate SFRP1 in cancer cells. Aberrant promoter ...
Lee Byung-heon (biochemist)
"Targeting Bladder Tumor Cells in vivo and in the Urine with a Peptide Identified by Phage Display". Molecular Cancer Research. ... "An apoptosis-homing peptide-conjugated low molecular weight heparin-taurocholate conjugate with antitumor properties". ... including the bladder tumor-targeting peptide, atherosclerotic plaque-homing peptide, and IL-4 receptor-binding peptide.We also ... preventing and treating atherosclerosis and uses thereof US 7968081 KR 20080090610 Bladder tumor-targeting peptide and use ...
The final step is connecting the ureter from the donor kidney to the bladder. In most cases, the kidney will soon start ... coagulation must be prevented with large amounts of anti-coagulation agents such as heparin. Several ethical and procedural ... The donor ureter is anastomosed with the recipient bladder. There is disagreement in surgical textbooks regarding which side of ...
60S ribosomal protein L22
Fujita Y, Okamoto T, Noshiro M, McKeehan WL, Crabb JW, Whitney RG, Kato Y, Sato JD, Takada K (March 1994). "A novel heparin- ... Chen KC, Chiang HS, Fang CL (2005). "EBER expression of pure urinary bladder lymphoepithelioma-like carcinoma in two unique ... The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals ...
Bladder mucosa is one of the tissues that express high levels of H19 RNA prenatally. In bladder cancers, H19 is also ... heparin-binding growth factor-like growth factor, intracellular adhesion molecule 1, NF-κB, ephrin A4 and ezrin. It is also ... were associated with a decreased risk of developing non-muscle invasive bladder cancer as well as bladder cancer overall; ... When a cancer bladder cell line, T24P, which does not express H19 was transfected with a DNA construct expressing the H19 gene ...
... of the bladder, tumors that do not invade the muscle of the bladder, tumors located within bladder diverticulum, or cancer that ... Compression devices placed around the legs or medications such as Heparin or low molecular weight heparin (LMWH) are commonly ... American Bladder Cancer Society A site created for and by Bladder Cancer (BLC) survivors, people with symptoms and the people ... The bladder is separated from surrounding structures and removed. The urethra, which drains urine from the bladder, may also be ...
If blood clots in the bladder, this can obstruct the bladder and lead to urinary retention. The majority of bleeding that ... These medications include aspirin, clopidogrel, heparin and warfarin. Desmopressin may be administered intravenously in the ... Damage to surrounding structures, such as bowel and bladder (more likely with transplant kidney biopsy), can occur. ... warfarin or heparin) pregnancy urinary tract infection obesity Like most invasive medical procedures, a renal biopsy is not ...
A 14-year-old girl with NF1 was diagnosed with a neurofibroma involving her bladder, a rare location. Once a plexiform ... and angiogenic factors such as the heparin-binding growth factor midkine. These chemicals promote the migration of different ... Meesa IR, Junewick JJ (August 2008). "Pelvic plexiform neurofibroma involving the urinary bladder". Pediatric Radiology. 38 (8 ...
... heparin-binding EGF-like growth factor (HB-EGF), and tumor necrosis factor (TNF), which can increase the growth of the tumor. ... bladder and renal cancer. High levels of endothelial FasL are accompanied by few CD8+ T cells, but abundant Treg cells. In ... urothelial bladder cancer and renal cell cancer. In mice, anti-CTLA-4 therapy leads to clearance from the tumor of Foxp3+ ...
Guizhentang Pharmaceutical Company
The use of heparin appears to improve survival and decrease the risk of blood clots. In 2008, approximately 12.7 million ... "Screening for Bladder Cancer". U.S. Preventive Services Task Force. 2004. Archived from the original on 23 August 2010. " ... It also causes cancer in the larynx, head, neck, stomach, bladder, kidney, esophagus and pancreas. Tobacco smoke contains over ... Parasitic infections associated with cancer include Schistosoma haematobium (squamous cell carcinoma of the bladder) and the ...
New England Compounding Center meningitis outbreak
"Screening for Bladder Cancer". U.S. Preventive Services Task Force. 2004. Archived from the original on 23 August 2010.. ... The use of heparin appears to improve survival and decrease the risk of blood clots.[needs update] ... Routine screening is not recommended for bladder cancer, testicular cancer, ovarian cancer, pancreatic cancer,[ ... Tobacco smoke, for example, causes 90% of lung cancer. It also causes cancer in the larynx, head, neck, stomach, bladder, ...
List of OMIM disorder codes
heparin binding. • protein serine/threonine kinase activator activity. • metal ion binding. • peptidase activity. • protein ... The anticancer activity of bovine lactoferrin (bLF) has been demonstrated in experimental lung, bladder, tongue, colon, and ... polysaccharides and heparin, and shows some of its biological functions in complexes with these ligands. ...
Treatment is with oral anticoagulants (not heparin as heparin acts via anti-thrombin 3 which is lost in the proteinuria so it ... Bladder. *Cystitis *Interstitial cystitis. *Hunner's ulcer. *Trigonitis. *Hemorrhagic cystitis. *Neurogenic bladder dysfunction ... Thrombophilia: low molecular weight heparin (LMWH) may be appropriate for use as a prophylactic in some circumstances, such as ... heparin is given for at least 5 days along with oral anticoagulants (OAC). During this time and if the prothrombin time is ...
Virus del Zika - Viquipèdia, l'enciclopèdia lliure
"Screening for Bladder Cancer". U.S. Preventive Services Task Force. 2004. Archived from the original on 23 August 2010. ... The use of blood thinners such as heparin decrease the risk of blood clots but have not been shown to increase survival in ... Routine screening is not recommended for bladder cancer, testicular cancer, ovarian cancer, pancreatic cancer,[ ... Tobacco smoke, for example, causes 90% of lung cancer. It also causes cancer in the larynx, head, neck, stomach, bladder, ...
위키백과:미번역 문서/의학 - 위키백과, 우리 모두의 백과사전
The final step is connecting the ureter from the donor kidney to the bladder. In most cases, the kidney will soon start ... coagulation must be prevented with large amounts of anti-coagulation agents such as heparin. Several ethical and procedural ... The donor ureter is anastomosed with the recipient bladder. There is disagreement in surgical textbooks regarding which side of ...
New Approaches in Managing Interstitial Cystitis/Bladder Pain Syndrome
Intravesical lidocaine with heparin and/or sodium bicarbonate may be used for those who have acute episodes of severe bladder ... ABSTRACT: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition of the bladder, which causes pain or ... Dysfunction of bladder urothelium and bladder urothelial cells in interstitial cystitis. Curr Urol Rep. 2006;7(6):440-446.. 7. ... Interstitial cystitis (IC) and bladder pain syndrome (BPS) or painful bladder syndrome are terms that are used together to ...
Northside Hospital - Interstitial cystitis
Medicines placed directly into the bladder, including dimethyl sulfoxide (DMS), heparin, Clorpactin, lidocaine, doxorubicin, or ... Bladder training (using relaxation techniques to train the bladder to go only at specific times) ... Over-filling the bladder with fluid while under general anesthesia (bladder hydrodistention) ... Painful bladder syndrome/interstitial cystitis and related disorders. In: Wein AJ, ed. Campbell-Walsh Urology. 10th ed. ...
Pentosan - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Pentosan is similar to a group of drugs called low molecular weight heparins, which help prevent irritation of the bladder ... Tell your doctor if you are going to have a surgery, or if you are taking warfarin (Coumadin, Jantoven), heparin, aspirin, or ... Pentosan treats inflammation and/or irritation of the bladder. Take this medication 1 hour before, or 2 hours after meals.. ... Pentosan is a prescription medication used to treat pain and discomfort due to interstitial cystitis (IC). IC is bladder ...
Pentosan Polysulfate Sodium Monograph for Professionals - Drugs.com
Weak anticoagulant following oral administration compared with heparin (1/15 activity of heparin); may increase bleeding times. ... layer and restore bladder integrity (by adhering to surface of bladder); acts as a buffer to control cell permeability and ... Symptomatic relief of bladder pain or discomfort associated with interstitial cystitis;1 2 6 7 designated an orphan drug by FDA ... Bladder Infection ciprofloxacin, amoxicillin, cephalexin, Levaquin, Keflex, levofloxacin, nitrofurantoin, Macrobid, cefuroxime ...
Heparin in bladder instillations - HELP! | Medical Billing and Coding Forum - AAPC
... always bills Heparin. I just want to make sure we are billing them correctly. I... ... J1644 1 unit (Heparin). J2001-59 1 unit (lidocaine). A4550 (sterile tray). With this newly found error in units for Heparin - ... Our urogynecology office does bladder instillations frequently, & always bills Heparin. I just want to make sure we are billing ... But, I can tell you how we bill Heparin.. 51700. J1644 X40. 81002. The HCPCS book reads that J1644 is per 1000 units. So, ours ...
Heparin: Blood Thinner or Anticoagulant Drug Used to Prevent Blood Clots - Health Video | Medindia
Heparin is an anticoagulant drug or blood thinner which is used to treat or prevent blood clots in deep vein thrombosis, ... Heparin is an anticoagulant drug or blood thinner which is used to treat or prevent the formation of blood clots in conditions ... Heparin: Blood Thinner or Anticoagulant Drug Used to Prevent Blood Clots. Developed by Medindia Content Team ...
When is early anticoagulation with heparin indicated for prevention of recurrent posterior cerebral artery (PCA) stroke?
While historically, early anticoagulation (generally with heparin infusion) has been used in ac... more ... When is early anticoagulation with heparin indicated for prevention of recurrent posterior cerebral artery (PCA) stroke?. ... Indeed, early anticoagulation, particularly with heparin, has been studied in a number of diagnostic settings but has not been ... encoded search term (When is early anticoagulation with heparin indicated for prevention of recurrent posterior cerebral artery ...
Heparin - tolerance - IC Patient Support Forum - Interstitial Cystitis, Bladder & Pelvic Pain
Heparin is usually given as an injection, but is also used as a bladder instillation. I used it for quite a while, but found ... DMSO, Cystistat, Heparin - Interstitial cystitis bladder instillations *Thank you for visiting the ICN Support Forum. We are so ... Dawn i take heparin treatments 1-3x a day. for the pass three-four mths and so far i havent had this to happen i cant say it ... The heparin didnt stop working.. I agree with Liz --- getting old is not for cowards!. Sending healing thoughts,. Donna ...
Heparin Instills?? - IC Patient Support Forum - Interstitial Cystitis, Bladder & Pelvic Pain
heparin acts on the bladder lining. sodium bicarbonate foams inside the bladder and allows the heparin be infused into the ... He says heparin is very similar to the bladders GAG layer, and so it kind of coats the bladder.. I know I get almost ... I tried Heparin instills, it burned my bladder really badly, so the doctor stopped them after a few tries.. I hope this ... DMSO, Cystistat, Heparin - Interstitial cystitis bladder instillations *Thank you for visiting the ICN Support Forum. We are so ...
units | Medical Billing and Coding Forum - AAPC
Heparin - Interstitial Cystitis Association
A heparin solution of 10,000 units diluted with saline solution is instilled intravesically daily, and held in the bladder for ... Heparin Heparin is a compound that has both anti-inflammatory and surface protective actions. Heparin can mimic the activity of ... The side effects of bladder instillation of heparin are limited primarily to pain, irritation, or discomfort resulting from ... Clinical studies on the effectiveness of heparin are limited. In one uncontrolled investigation, intravesical heparin resulted ...
Bladder Installations For Treatment of Interstitial Cystitis
... medications can be placed directly into the bladder to provide treatment and pain relief for interstitial cystitis and bladder ... Heparinoid instillations (Heparin & Hyaluronic Acid). - Heparin. Heparin is believed to act as a bladder coating. Several ... Step 2 - Bladder Instillations For ICJill Osborne2018-07-24T16:15:24-07:00 Step 2 - Bladder Instillations. Bladder ... If it numbs the bladder wall and/or reduces bladder discomfort, it "rules in" the bladder wall as the source of patient ...
Dr. Adam Gafni-Kane | NorthShore
Which bladder instillations are more effective? DMSO vs. bupivacaine/heparin/triamcinolone: a retrospective study.. ... Bladder Control, Bladder Pain, Botox, Female Incontinence, Fistula, Painful Bladder Syndrome, Recurrent uti, Urinary ... Bladder Sling, Botox Injection, Cystoscopy, Hysterectomy, InterStim Therapy, Laparoscopic Surgery, Laproscopic Hysterectomy, ... Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic and debilitating condition. Our objective was to compare two ...
A Trial of Intravesical Therapy for Interstitial Cystitis in Patients With Generalized Vulvodynia - Full Text View -...
Drug: Bladder instillation with heparin/ lidocaine 9 bladder instillations in 6 weeks ... Urinary Bladder Diseases. Urologic Diseases. Vulvar Diseases. Genital Diseases, Female. Lidocaine. Heparin. Anesthetics, Local ... In order to investigate whether the pain in women with vulvodynia may represent bladder origin pain, we will be performing a ... Those women with a positive test for IC, we will be performing a series of bladder treatments (instillations) for IC and ...
New USP Standards for Heparin Products Will Result in Decreased Potency | P&T Community
First Targeted Treatment for Metastatic Bladder Cancer More Than 32% of Patients Responded in Trial ... Four companies market heparin in the United States. APP, the largest manufacturer, markets heparin in vials; Hospira markets ... heparin in intravenous bags, vials, and syringes; Baxter markets heparin in intravenous bags, and B. Braun markets heparin in ... For heparin, a unit dose is the measure of the drugs ability to block the bloods natural clotting ability (anticoagulation). ...
FDA: Heparin Products Hike Risk of Spinal Procedures | MedPage Today
Physicians should be extra careful with spinal procedures in patients taking low molecular weight heparins because of increased ... These include midline back pain, sensory or motor deficits in the lower extremities, or bowel or bladder dysfunction. ... FDA: Heparin Products Hike Risk of Spinal Procedures. by John Gever, Deputy Managing Editor, MedPage Today November 6, 2013 ... Physicians should be extra careful with spinal procedures in patients taking low molecular weight heparins (LMWH) because of ...
Interstitial Cystitis (Painful Bladder Syndrome)Therapeutics Drugs Profile and Key Companies Pipeline Review, H2 2016 | Business
Interstitial Cystitis (Painful Bladder Syndrome) - Pipeline Review, H2 2016, provides an overview of the Interstitial Cystitis ... Interstitial Cystitis (Painful Bladder Syndrome)Therapeutics Drugs Profile and Key Companies Pipeline Review, H2 2016. ... Scope of Interstitial Cystitis (Painful Bladder Syndrome) Pipeline Review Report-. - The report provides a snapshot of the ... List of Figures of Interstitial Cystitis (Painful Bladder Syndrome) Therapeutics Market Included:. • Number of Products under ...
Search of: Central Pain Syndrome - List Results - ClinicalTrials.gov
Efficacy Study of Pentosan Polysulfate Sodium,Hydrodistension and Combination Therapy for Bladder Pain Syndrome. *Bladder Pain ... Drug: Heparin. Interventional. Phase 2. *Urigen. Industry. *Allocation: Randomized. *Intervention Model: Parallel Assignment ... Change in bladder pain differences from baseline as determined by using the Visual Analog Scale (VAS) ... Engage 24: Evaluation of the Safety and Effectiveness of URG101 in Subjects With Interstitial Cystitis/Bladder Pain Syndrome. * ...
Urinary Tract Infections Clinical Research Trials | CenterWatch
... demonstrate that Heparin bladder instillations reduce the number of UTI episodes; 2) demonstrate Heparin bladder instillations ... demonstrate that Heparin bladder instillations decrease urine inflammatory (NGAL) levels. Study Design: This study will be ... ... Recurrent Urinary Tract Infections and Heparin (RUTIH Trial) Primary Objectives: The specific aims of this study are to 1) ... Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury ...
Archived Coding Questions | AUGS
How do you code for bladder instillation of Heparin, Lidocaine and Solumedrol for painful bladder patients?. Per the AUGS ... How do you code for bladder instillation of Heparin, Lidocaine and Solumedrol for painful bladder patients? ... Does anyone know the best CPT code for a tampon dye test, retrofilling the bladder with dye and placing tampon in vagina?. Per ... Does anyone know the best CPT code for a tampon dye test, retrofilling the bladder with dye and placing tampon in vagina? ...
Dalteparin (Professional Patient Advice) - Drugs.com
Anticoagulant, Low Molecular Weight Heparin. Pharmacology. Low molecular weight heparin analog with a molecular weight of 4,000 ... Signs and symptoms of neurological impairment (eg, midline back pain, sensory/motor deficits, bowel and/or bladder dysfunction ... The spironolactone Canadian product monograph lists its combination with heparin or low molecular weight heparins as ... Conversion from IV unfractionated heparin (UFH) infusion to SubQ dalteparin (Nutescu 2007): Calculate specific dose for ...
Interstitial Cystitis & Bladder Pain Syndrome | GLOWM
Theoretically, heparin replenishes the GAG layer in the bladder, thereby decreasing inflammation and increasing bladder ... Analgesic bladder challenge. Anesthetizing the bladder may determine whether the bladder is the origin of pain by proving pain ... 84 The mechanism of action of bladder distention remains obscure. Stretching the bladder wall may increase bladder capacity and ... Bladder epithelial cells from patients with interstitial cystitis produce an inhibitor of heparin-binding epidermal growth ...
Pemigatinib before Surgery for the Treatment of Recurrent Low- or Intermediate Risk Non-Muscle Invasive Bladder Cancer -...
... or Intermediate Risk Non-Muscle Invasive Bladder Cancer - NCT03914794 ... Full-dose anti-coagulation with low molecular weight heparin is permitted. * Patients with a prior history of significant ... In non-muscle invasive bladder cancer, FGFR3 gene mutations have been seen in patients with recurrent bladder tumors and a ... Pemigatinib before Surgery for the Treatment of Recurrent Low- or Intermediate Risk Non-Muscle Invasive Bladder Cancer Trial ...
Klippel-Trénaunay Syndrome - NORD (National Organization for Rare Disorders)
Anticoagulation with heparin is often necessary prior to radiologic or surgical intervention. Large venous channels can be ... LM and VM can also involve the pelvic or abdominal organs resulting in bleeding from the rectum, vagina or urinary bladder. ... Bleeding lesions in the bladder can be controlled by laser done through a cystoscope. An elastic compressive stocking is often ... The lymphatic anomalies can also occur in the pelvis, bladder and lower gastrointestinal tract. Lymphatic cysts in the spleen ...
The kind of juice you drink affects the amount of iron you get (2002) - Page 2 | HysterSisters
Latest Likes For alibee | allnurses
I occasionally get people with DVTs who need a heparin drip. I dont see a lot of trachs. But for the most part, you help get ... If they had their gall bladder taken out, is there a bile leak?). Ideal day goes:. - Get there a little early and check 6am ... Med passes arent terrible unless a patient also has high blood pressure/blood sugar issues (usually just lovenox/heparin, ...
Bladder Pain Syndrome - An Evolution | Springer for Research & Development
... as well as information on the developments that have occurred within bladder pain syndrome since the publication of the first ... The Prevalence of Bladder Pain Syndrome/Interstitial Cystitis in Italy: The importance of a National Registry ... Placing Interstitial Cystitis/Bladder Pain Syndrome on the Map: The Story of the Interstitial Cystitis Association ... This book is relevant to clinicians who focus on bladder pain syndrome, as well as the gynaecologists, general urologists, and ...
Check drug and medication side effect reports associated with Bladder Pain ... What drug can cause Bladder Pain as their side effect? ... heparin. Episodes: 7. cystitis interstitial.back pain , bladder ... What is BLADDER PAIN? accupril. Episodes: 1. hypertension, bladder cancer .bladder cancer , bladder pain, chills, difficulty in ... bladder pain, blood urine present More. immucyst. Episodes: 24. bladder cancer .bladder pain, contracted bladder, pollakiuria ...
My pee is hot!
Bladder Instillation Therapy *Rescue Instillations For Interstitial Cystitis. *DMSO, Cystistat, Heparin - Interstitial cystitis ... when I flare it feels like hot acid to me! I was told to lay heavily on the bottled water to try and rinse the bladder out or ... But he was not an ic expert). I believe it was that my bladder was so inflammed it was hot & heating up my urine! I have not ... Knock on wood, the Elmiron has helped my bladder, now I just deal with a burning urethra all the time-ugh! Try drinking the ...
EGFR | China-Mainland | Sigma-Aldrich
Heparin binding-EGF (HB-EGF) (SRP3052). Betacellulin (BTC) (B3670). Epiregulin (EPR) (E8780). Epigen (EPG) (SRP4969). Does not ... Malignant neoplasms of the breast, ovary, pancreas, lung, prostate, bladder, colon. Role of ErbB4 in malignancies is not well ... Heparin binding- EGF (HB-EGF) (SRP3052). Epiregulin (EPR) (E8780). Neuregulin-3 (NRG-3). Neuregulin-4 (NRG-4). ... Heparin-binding EGF-like growth factor Disease. Relevance. ... bladder. Hyperplasias, benign and malignant, neoplasms and ...
Duration of anticoagulant therapy and VTE recurrence in patients with cancer | SpringerLink
Actual use of low-molecular-weight heparin in cancer. Neth J Med 72(9):467-472PubMedGoogle Scholar ... bladder, testicular, or renal cancer). PE, with or without a concomitant DVT diagnosis, was more frequent in patients treated ... RVTE, recurrence of VTE; LMWH, low-molecular-weight heparin. 1Duration of therapy was calculated from the first anticoagulant ... Akl EA, Barba M, Rohilla S, Terrenato I, Sperati F, Muti P, Schunemann HJ (2008) Low-molecular-weight heparins are superior to ...
foxd1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog
Epigallocatechin-3-gallate alleviates bladder overactivity in a rat model with metabolic syndrome and ovarian hormone...
MetS + OVX deteriorated bladder storage dysfunction more profound than MetS alone. MetS and MetS + OVX rats showed over- ... Moreover, OVX exacerbated MetS related bladder apoptosis (2.3~4.5-fold of control; 1.8~2.6-fold of Mets group), enhances ... EGCG reduced the generation of oxidative stress and lessened bladder overactivity. ... on bladder overactivity. Rats were fed with high fat high sugar (HFHS) diet to induce MetS and received ovariectomy surgery to ...
Called low molecular weight heparinsDiscomfortSymptomsCystitisUrineTreatmentsInflammationEpithelialWarfarinPatientsWallInstillationsInstillationTaking low molecular weight heparinsOveractive bladderLMWHMucosaAnticoagulantMolecularGlycosaminoglycan40,000 unitsDysfunctionPelvisKidneyHysterectomyUrgencySyndromeCause bladderAnticoagulationPatients with bladder cancerInflammatory disease of the bladderInjectionHunnerCancerPentosan polysulfateFound in the bladderCystectomyMedicationsPelvic PainABSTRACTProphylaxisSignificantlyFills
Called low molecular weight heparins1
- Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition of the bladder, which causes pain or discomfort in the absence of infection or other identifiable causes. (uspharmacist.com)
- Interstitial cystitis (IC) and bladder pain syndrome (BPS) or painful bladder syndrome are terms that are used together to describe a chronic condition involving bladder pain or discomfort, which can have a significant impact on quality of life. (uspharmacist.com)
- 2 The American Urological Association (AUA) guideline defines IC/BPS as "an unpleasant sensation (pain, pressure, discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms of more than six weeks' duration, in the absence of infection or other identifiable causes. (uspharmacist.com)
- The most common symptom is an increase in discomfort with bladder filling and relief with voiding. (uspharmacist.com)
- 6 months) urinary bladder pain or discomfort, accompanied by other urinary symptom such as persistent urge to void [ 1 ]. (biomedcentral.com)
- Delayed immunoallergic thrombocytopenia similar to heparin-induced thrombocytopenia with symptoms of thrombosis and hemorrhage reported with sub-Q, IM, or sublingual administration of a different formulation of pentosan polysulfate. (drugs.com)
- The present study investigated the expressions of histamine receptors in the bladder wall tissues of patients with BPS/IC, and its association with the effectiveness of antihistamine therapy and disease symptoms. (biomedcentral.com)
- however, since there is no clear evidence that bladder inflammation (cystitis) is involved in the pathophysiology or that the condition is associated with abnormalities of the interstices of the bladder, it has been thought to be misnamed. (uspharmacist.com)
- Activation of mast cells plays an important role in the pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC). (biomedcentral.com)
- 1,6 The GAG layer helps protect the bladder from surface irritants, so if it is altered, irritants may leak from the urine into the bladder tissue, resulting in pain and inflammation. (uspharmacist.com)
- Several etiologies have been proposed, including abnormalities in urine, infection, inflammation resulted from autoimmunity, activation of mast cells, neurogenic inflammation, and disturbance in permeability of the bladder wall [ 4 ]. (biomedcentral.com)
- Pentosan treats inflammation and/or irritation of the bladder. (rxwiki.com)
- IC is bladder inflammation or irritation. (rxwiki.com)
- Histamine, a mast cell-derived mediators, induced inflammation and hypersensitivity of the bladder. (biomedcentral.com)
- and the binding of histamine to the receptors on bladder wall could induce inflammation and hypersensitivity of the bladder [ 7 , 8 ]. (biomedcentral.com)
- Urothelial abnormalities have been found in IC/BPS cases, including an autoimmune or immunologic response causing altered bladder epithelial expression of specific antigens, alterations in the glycosaminoglycan (GAG) layer, and altered cytokeratin profile. (uspharmacist.com)
- It has been confirmed that the expression of all the four subtypes of histamine receptors were found in BPS/IC animal model, in which the receptors were expressed mainly in bladder epithelial cells. (biomedcentral.com)
- Our urogynecology office does bladder instillations frequently, & always bills Heparin. (aapc.com)
- Patients treated with DMSO alone had a relapse rate of 52 percent, while those maintained with monthly instillations of heparin and followed for 12 months had a relapse rate of 20 percent. (ichelp.org)
- Bladder instillations are a second-line treatment option in the AUA Guidelines for IC/BPS when treatments such as diet modifications, stress management, and over the counter products are not enough. (ic-network.com)
- That said, bladder instillations may cause bladder and/or urethral discomfort of varying degrees. (ic-network.com)
- Cystistat and Hyacyst are HA bladder instillations approved for use in Canada and Europe. (ic-network.com)
- Those women with a positive test for IC, we will be performing a series of bladder treatments (instillations) for IC and checking symptoms throughout the trial to see if significant relief of vulvar pain can be obtained through treatment for IC. (clinicaltrials.gov)
- In order to receive bladder instillations, patients will need to have a positive potassium sensitivity test. (clinicaltrials.gov)
- and 3) demonstrate that Heparin bladder instillations decrease urine inflammatory (NGAL) levels. (centerwatch.com)
- Had series of 8 weekly BCG (bacillus calmette guerin) bladder instillations yrs ago for interstitial cystitis. (healthtap.com)
- Had BCG bladder instillations 10 yrs ago for interstitial cystitis. (healthtap.com)
- Has recently received DMSO or heparin intravesical instillations . (ichelp.org)
- Heparin is usually given as an injection, but is also used as a bladder instillation. (ic-network.com)
- While this drug can be given either by injection or by bladder instillation, the method of choice for the treatment of IC is bladder instillation. (ichelp.org)
- The side effects of bladder instillation of heparin are limited primarily to pain, irritation, or discomfort resulting from frequent catheterization. (ichelp.org)
- During a bladder instillation (aka intravesical instillation or treatment), the bladder is filled with medication via a catheter. (ic-network.com)
- He feels that this is best suited for patients with clear bladder wall driven pain and encourages patients to learn how to self-catherize so that they can use this instillation during flares and gain empowerment. (ic-network.com)
- Do the bladder instillation treatments of heparin, bicarbinate of soda, and lidocane help bladder inflamation? (healthtap.com)
- PMID:18751498) - effectiveness, safety nd tolerability of instillation therapy with chondroitin sulphate was investigated in 286 patients with chronic forms of cystitis including radiation cystitis, overactive bladder, chronically recurring cystitis and IC. (painful-bladder.org)
Taking low molecular weight heparins1
- Based on the 2016 American College of Chest Physicians (ACCP) guidelines for antithrombotic therapy for VTE disease , low molecular weight heparin (LMWH) (eg, dalteparin) is an effective and recommended treatment option for acute DVT. (drugs.com)
- The object of this study was to determine if low-molecular-weight heparin (LMWH) was safe and effective if given within 24 hours of SCI. (thejns.org)
- Hyaluronic Acid (HA) is a naturally found in the bladder mucosa where it helps to protect the underlying tissue. (ic-network.com)
- Our previous investigation demonstrated that ovarian hormone deficiency in the OVX rats resulted in diminishing bladder compliance, increasing oxidative damage and interstitial fibrosis, and enhancing bladder mucosa apotosis 6 . (nature.com)
- A bladder diverticulum is a herniation of the bladder mucosa through a defect in bladder muscle. (merckmanuals.com)
- In exstrophy, there is a failure of midline closure from the umbilicus to the perineum, resulting in bladder mucosa continuity with the abdominal skin, separation of the pubic symphysis, and epispadias or bifid genitalia. (merckmanuals.com)
- Heparin is an anticoagulant drug or blood thinner which is used to treat or prevent the formation of blood clots in conditions like deep vein thrombosis, arterial thromboembolism, pulmonary embolism, extracorporeal circulation or ecmo circuit, and disseminated intravascular coagulation. (medindia.net)
- Authoritarian styles of interaction of protamine a heparin anticoagulant rebound effect is obtained. (childbirthsolutions.com)
- Pentosan polysulfate is similar to a class of medications called low molecular weight heparins. (medlineplus.gov)
- Treating the cells with two low molecular weight heparins (LMWHs) that are already in clinical use also inhibited the binding, but only partially and not as strongly. (news-medical.net)
- Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha. (ica-ev.de)
- The first one is antiproliferative factor (APF), a low molecular weight frizzled-8 related peptide that inhibits the growth of bladder epithelial cells. (contemporaryobgyn.net)
- The current procedure for detecting bladder tumors with potential progression is difficult and error-prone, and new biomarkers are needed to optimize the molecular characterization of tumors ( 4 , 5 ). (aacrjournals.org)
- Patient was extubated the day after and started on a heparin infusion and transitioned to low molecular weight heparin. (soap.org)
- Venous thromboembolism prophylaxis using low-molecular-weight heparin is recommended by current guidelines for SCI. (thejns.org)
- Urothelial abnormalities have been found in IC/BPS cases, including an autoimmune or immunologic response causing altered bladder epithelial expression of specific antigens, alterations in the glycosaminoglycan (GAG) layer, and altered cytokeratin profile. (uspharmacist.com)
- In addition, a study by one group suggested that the soluble glycosaminoglycan heparin can inhibit the entry of SARS CoV-2 into "Vero" cells - a cell line derived from monkey kidney epithelia. (news-medical.net)
- These include midline back pain, sensory or motor deficits in the lower extremities, or bowel or bladder dysfunction. (medpagetoday.com)
- Metabolic syndrome (MetS) and ovarian hormone deficiency could affect bladder storage dysfunction. (nature.com)
- MetS + OVX deteriorated bladder storage dysfunction more profound than MetS alone. (nature.com)
- EGCG pretreatment alleviated storage dysfunction, and protected the bladders from MetS and OVX - induced interstitial fibrosis changes. (nature.com)
- Mitochondrial function is considered relating to MetS associated oxidative stress 8 , but the mechanisms of MetS and ovarian hormone deficiency in relation to bladder dysfunction are still not clearly elucidated. (nature.com)
- Neurogenic bladder is bladder dysfunction caused by neurologic disorders, including spinal cord or CNS abnormalities, trauma, or the sequelae of pelvic surgery (eg, for sacrococcygeal teratoma or imperforate anus ). (merckmanuals.com)
- Elucidation of mechanisms that influence urothelial function might provide insights into the pathology of bladder dysfunction. (pubmedcentralcanada.ca)
- 1 3 The bladder is one of the most sensitive organs in the pelvis and one of the most common sources of pain in patients with CPP. (glowm.com)
- The lymphatic anomalies can also occur in the pelvis, bladder and lower gastrointestinal tract. (rarediseases.org)
- It is a chronic condition of the bladder that causes pain in the pelvis and low abdomen. (healthtap.com)
- The bladder can usually be reconstructed and returned to the pelvis, although vesicoureteral reflux invariably occurs and is managed as needed. (merckmanuals.com)
- The urothelium is the epithelial lining of the urinary tract between the renal pelvis and the urinary bladder. (pubmedcentralcanada.ca)
- Allegations in this complex case include negligence in performing laparoscopic hysterectomy and delaying treatment of bladder injury. (contemporaryobgyn.net)
- During the hysterectomy, she sustained a bladder injury. (contemporaryobgyn.net)
- Hysterectomy was completed and the bladder dome was repaired. (soap.org)
- During the test, patients are asked to report the degree of severity of pain and urgency that they experience while the KCl solution is in the bladder. (ichelp.org)
- The data indicate that these combined medications will effectively and immediately relieve both bladder pain and urgency for up to 12 or more hours and provide significant immediate relief for IC patients," the authors write. (empr.com)
- Drugs used for the treatment of OAB (over active bladder) are sometimes given to reduce or eliminate the increased urgency and frequency of urination caused by the presence of the stent. (wikipedia.org)
- If the bladder wall becomes scarred, bladder compliance and capacity decrease, causing or worsening urinary urgency and frequency. (merckmanuals.com)
- People with bladder pain often get in the habit of using the bathroom as soon as they are aware of any need to go to avoid pain or urgency . (nih.gov)
- This updated volume provides reflections on the original edition, as well as information on the developments that have occurred within bladder pain syndrome since the publication of the first edition. (springer.com)
- This book is relevant to clinicians who focus on bladder pain syndrome, as well as the gynaecologists, general urologists, and primary care providers who see these patients as a part of their practice. (springer.com)
- He presented IC/PBS is a multifactorial pain syndrome that can involve the bladder, the pelvic floor and musculoskeletal system, and the central and peripheral nervous systems. (pelvicpainrehab.com)
- When is early anticoagulation with heparin indicated for prevention of recurrent posterior cerebral artery (PCA) stroke? (medscape.com)
- While historically, early anticoagulation (generally with heparin infusion) has been used in acute stroke, significant supporting data have been absent. (medscape.com)
- Indeed, early anticoagulation, particularly with heparin, has been studied in a number of diagnostic settings but has not been demonstrably proven to be beneficial. (medscape.com)
- For heparin, a unit dose is the measure of the drug's ability to block the blood's natural clotting ability (anticoagulation). (ptcommunity.com)
- PPS is a heparin analogue that has 1/15th the anticoagulation activity of heparin. (arhp.org)
Patients with bladder cancer1
Inflammatory disease of the bladder1
- As to bladder injection of Botox for IC, please ask your urologist for details on indication, expectations, complications, etc. timely besides viewing IC-related articles from many websites about IC, OAB, etc. (healthtap.com)
- As the effects of heparin are short-lived, administration by intravenous infusion or subcutaneous injection is preferable to intermittent intravenous injections. (medicines.org.uk)
- Heparin should not be administered by intramuscular injection or after major trauma. (medicines.org.uk)
- the IV catheter's patency was maintained with injection of 50 U of heparin once daily throughout the treatment period. (aappublications.org)
- 9 Guy Hunner further supported this idea by describing patients with hemorrhagic areas in the bladder later know as Hunner's ulcers. (glowm.com)
- In approximately 10% of IC/BPS cases, Hunner lesions or patches of broken skin on the bladder wall are present. (uspharmacist.com)
- In the early 1900s, Dr. Guy Hunner identified via cystoscope that some people with IC had lesions in their bladder lining and subsequently the term 'Hunner's Ulcers' was coined. (pelvicpainrehab.com)
- Data from a randomized open label study comparing dalteparin to continuous IV infusion unfractionated heparin for the initial treatment of acute deep venous thrombosis (DVT) supports the use of dalteparin in the treatment of acute DVT in patients without cancer [Fiessinger . (drugs.com)
- This phase II trial studies how well pemigatinib before surgery works in treating patients with low- or intermediate risk non-muscle invasive bladder cancer that has come back (recurrent). (cancer.gov)
- In non-muscle invasive bladder cancer, FGFR3 gene mutations have been seen in patients with recurrent bladder tumors and a prior history of low or intermediate risk tumors. (cancer.gov)
- Pemigatinib followed by surgery may be an effective treatment in patients with low- and intermediate risk non-muscle invasive bladder cancer. (cancer.gov)
- Studies do not include a risk of cancer of the bladder . (healthtap.com)
- Intravesical bcg is only appropriate for bladder cancer . (healthtap.com)
- This is to check for bladder cancer and other rare causes of bladder pain. (mayoclinic.org)
- biopsy is required to exclude bladder cancer. (merckmanuals.com)
- The purpose of this study was to determine the gene and protein expression profiles of ADAM12 in different grades and stages of bladder cancer. (aacrjournals.org)
- Gene expression in bladder cancer was validated using reverse transcription-PCR, quantitative PCR, and in situ hybridization. (aacrjournals.org)
- ADAM12 mRNA expression was significantly up-regulated in bladder cancer, as determined by microarray analysis, and the level of ADAM12 mRNA correlated with disease stage. (aacrjournals.org)
- ADAM12 is a promising biomarker of bladder cancer. (aacrjournals.org)
- The majority of patients diagnosed with bladder cancer present with non-muscle-invasive tumors. (aacrjournals.org)
- In this study, we propose that ADAM12, a disintegrin and metalloprotease, is a new and promising biomarker for bladder cancer. (aacrjournals.org)
- However, smoking is a major cause of bladder cancer . (nih.gov)
Found in the bladder1
- The presence of heparin and calcium also significantly reduced P. aeruginosa adherence density. (ersjournals.com)
- By data mining a published dataset of UC of bladder (UCB) transcriptome (GSE31684) from Gene Expression Omnibus, National Center of Biotechnology Information (GEO, NCBI), we identified that THBS2 was the most significantly upregulated gene among those related to structural molecule activity (GO:0005198). (jcancer.org)
- Exercise tolerance, the maximal double product, and the double product at the onset of angina and at the onset of ST segment depression were significantly improved in the heparin-treated group within 10 days but not in patients who exercised without receiving heparin. (ahajournals.org)
- Bowel and bladder disorders are common following SCI, significantly reduce quality of life, and constitute a focus of targeted therapies. (thejns.org)