The deformation and flow behavior of BLOOD and its elements i.e., PLASMA; ERYTHROCYTES; WHITE BLOOD CELLS; and BLOOD PLATELETS.
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.
The formation of clumps of RED BLOOD CELLS under low or non-flow conditions, resulting from the attraction forces between the red blood cells. The cells adhere to each other in rouleaux aggregates. Slight mechanical force, such as occurs in the circulation, is enough to disperse these aggregates. Stronger or weaker than normal aggregation may result from a variety of effects in the ERYTHROCYTE MEMBRANE or in BLOOD PLASMA. The degree of aggregation is affected by ERYTHROCYTE DEFORMABILITY, erythrocyte membrane sialylation, masking of negative surface charge by plasma proteins, etc. BLOOD VISCOSITY and the ERYTHROCYTE SEDIMENTATION RATE are affected by the amount of erythrocyte aggregation and are parameters used to measure the aggregation.
The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Books designed to give factual information or instructions.
Images used to comment on such things as contemporary events, social habits, or political trends; usually executed in a broad or abbreviated manner.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.
Radiography of the vascular system of the brain after injection of a contrast medium.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Pulsed Doppler ultrasonographic evaluation of portal blood flow in dogs with experimental portal vein branch ligation. (1/556)

Portal blood flow was measured using pulsed Doppler ultrasound in 6 dogs before and after left portal vein branch ligation. Mean portal vein blood flow velocity and mean portal vein blood flow were significantly reduced after ligation and the congestion index was increased (p < 0.01). Pulsed Doppler ultrasound studies provide valuable physiological information which may assist the clinician with the diagnosis of canine hepatic circulatory disorders.  (+info)

AJvW-2, an anti-vWF monoclonal antibody, inhibits enhanced platelet aggregation induced by high shear stress in platelet-rich plasma from patients with acute coronary syndromes. (2/556)

The platelet aggregation that is dependent on von Willebrand factor (vWF) is important in the thrombogenesis that occurs under conditions of high shear stress, eg, during acute coronary syndromes (ACSs). A monoclonal antibody, AJvW-2, directed against the A1 domain of human vWF specifically blocks the interaction between plasma vWF and platelet glycoprotein (GP) Ib. To evaluate the association between the vWF-GPIb interaction and the enhanced shear-induced platelet aggregation (SIPA) observed in ACSs, we tested the effect of this antibody on platelet aggregation. Platelet-rich plasma was prepared from the citrated blood of 12 patients with unstable angina (UAP) and 20 patients with acute myocardial infarction (AMI) who were admitted within 3 hours of the onset of cardiac symptoms and from 18 controls. We observed the following: (1) 1.7-fold higher plasma levels of vWF and ristocetin cofactor activity in UAP patients and (2) 2.8-fold higher levels in the AMI group than in controls. Using a cone-and-plate viscometer, we measured the mean value of SIPA under high-shear conditions (108 dyne/cm2) and found them to be 1.3-fold higher in the UAP group and 2.0-fold higher in the AMI group than in controls. The high SIPA in all groups was completely inhibited by 10 microgram/mL AJvW-2. Under low-shear conditions (12 dyne/cm2), platelet aggregation was increased only in the AMI group, but this was unaffected by AJvW-2. We observed a significant correlation in both ACS groups between high SIPA and the plasma vWF level or vWF larger multimers. These findings suggest that the vWF-GPIb interaction is important in coronary occlusion and that inhibition of this interaction (with the use of AJvW-2) may prevent further events in the coronary arteries.  (+info)

Shear stress-induced nitric oxide antagonizes adenosine effects on intestinal metabolism. (3/556)

The influence of nitric oxide (NO) on adenosine-induced metabolic effects was studied in the intestine. Blood flow supplied an in situ- isolated segment of small intestine in anesthetized cats via the superior mesenteric artery (SMA) and was controlled by a vascular circuit. The SMA and portal samples were taken for analysis of oxygen and lactate. Adenosine (0.4 mg. kg-1. min-1, intra-SMA) reduced oxygen consumption by 25.1 +/- 2.9 from 73.1 +/- 10.8 micromol. min-1. 100 g-1 and increased lactate production by 13.3 +/- 3.0 from 12.8 +/- 4.6 micromol. min-1. 100 g tissue-1 during constant-flow (CF, decreased shear stress) but not during constant-pressure (CP, increased shear stress) perfusion. Blockade of NO synthase using Nomega-nitro-L-arginine methyl ester did not affect the metabolic effects of adenosine during CF but eliminated the differences seen between CP and CF perfusion. A NO donor, 3-morpholinosydnonimine, attenuated the metabolic effects of adenosine during CF perfusion. The results suggested that shear-induced NO antagonized metabolic effects of adenosine but that the inhibition of vascular effects by NO was not shear dependent since it occurred in both CP and CF perfusion.  (+info)

Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. (4/556)

Shear stress, the tangential component of hemodynamic forces, activates many signal transduction pathways in vascular endothelial cells. The conversion of mechanical stimulation into chemical signals is still unclear. We report here that shear stress (12 dynes/cm2) induced a rapid and transient tyrosine phosphorylation of Flk-1 and its concomitant association with the adaptor protein Shc; these are accompanied by a concurrent clustering of Flk-1, as demonstrated by confocal microscopy. Our results also show that shear stress induced an association of alphavbeta3 and beta1 integrins with Shc, and an attendant association of Shc with Grb2. These associations are sustained, in contrast to the transient Flk-1. Shc association in response to shear stress and the transient association between alphavbeta3 integrin and Shc caused by cell attachment to substratum. Shc-SH2, an expression plasmid encoding the SH2 domain of Shc, attenuated shear stress activation of extracellular signal-regulated kinases and c-Jun N-terminal kinases, and the gene transcription mediated by the activator protein-1/12-O-tetradecanoylphorbol-13-acetate-responsive element complex. Our results indicate that receptor tyrosine kinases and integrins can serve as mechanosensors to transduce mechanical stimuli into chemical signals via their association with Shc.  (+info)

Characterization of eosinophil adhesion to TNF-alpha-activated endothelium under flow conditions: alpha 4 integrins mediate initial attachment, and E-selectin mediates rolling. (5/556)

The multistep model of leukocyte adhesion reveals that selectins mediate rolling interactions and that integrins mediate firm adhesion processes. In this study, the interaction between eosinophils and TNF-alpha-activated HUVEC (second or third passage) was studied under flow conditions (0.8 and 3.2 dynes/cm2). Especially the role of alpha 4 integrins on eosinophils and E-selectin on HUVEC was studied. Inhibition of the integrin alpha 4 chain on eosinophils reduced the number of firmly adhered resting eosinophils to TNF-alpha-stimulated endothelium by 43% whereas the percentage rolling cells increased 2.2-fold compared with untreated control eosinophils. Blocking of E-selectin on the endothelium reduced the number of adherent eosinophils by only 23% and 16%. In this situation, however, hardly any rolling adhesion was observed, and the few rolling cells showed a low rolling velocity. Blocking both alpha 4 integrin on eosinophils and E-selectin on HUVEC reduced the number of adhered eosinophils by 95%. P-selectin did not significantly participate in eosinophil adhesion to TNF-alpha-activated HUVEC. Inhibition of both alpha 4 integrins and beta 2 integrins on eosinophils resulted in a reduction of adhered cells by 65% and a 3-fold increase in percentage rolling cells. Taken together, these results clearly show that resting eosinophils preferentially use constitutively active alpha 4 integrins (alpha 4 beta 1, alpha 4 beta 7) for the first attachment to TNF-alpha-activated HUVEC. In addition, alpha 4 integrins and E-selectin work synergistically in eosinophil adherence to TNF-alpha-activated HUVEC. Although E-selectin is important for eosinophil rolling under these conditions, P-selectin plays only a minor role.  (+info)

P-selectin binding promotes the adhesion of monocytes to VCAM-1 under flow conditions. (6/556)

This study examined the adhesive interaction of peripheral blood monocytes with VCAM-1 and analyzed the effect of P-selectin binding to monocytes on the adhesive interaction with VCAM-1 under flow conditions. P-selectin glycoprotein ligand-1 is expressed on most monocytes. Furthermore, most monocytes bind soluble P-selectin derived from platelets. P-selectin binding to monocytes did not alter the amount of expression of alpha4 integrin on monocytes. However, the mean channel fluorescence value for binding Cy2-conjugated soluble VCAM-1 to P-selectin-bound monocytes was slightly more than that for binding Cy2-conjugated soluble VCAM-1 to untreated monocytes. Under flow conditions, the number of P-selectin-bound monocytes bound to VCAM-1 was much higher than that of untreated monocytes bound to VCAM-1. These bindings were abolished by pretreatment of untreated monocytes and P-selectin-bound monocytes with anti-VCAM-1 mAb or anti-alpha4 integrin mAb. Furthermore, P-selectin binding to monocytes increased shear resistance and thus increased the adhesive strength of monocytes to VCAM-1. These findings indicate that P-selectin binding to monocytes enhances the adhesive interaction of monocytes with VCAM-1. It is suggested that P-selectin glycoprotein ligand-1/P-selectin interaction and alpha4 integrin/VCAM-1 interaction can act sequentially in the adhesion cascade that regulates monocyte trafficking to inflammatory and atherosclerotic lesion.  (+info)

Power Doppler ultrasound scan imaging of the level of red blood cell aggregation: an in vitro study. (7/556)

PURPOSE: The purpose of this study was to evaluate the effect of the shear rate on red blood cell (RBC) aggregation with power Doppler ultrasound scanning (PDU), pulsed-wave Doppler scanning, and color Doppler flow imaging. METHODS: Equine and porcine blood were circulated with a steady flow in a phantom with a diameter of 9.52 mm. The color Doppler flow imaging mode was used to estimate the velocity profile and the shear rate across the tube. A transfer function that related the Doppler scan power, measured in gray level with the PDU method, to the power, measured in decibels with the pulsed-wave Doppler scan technique, was used to estimate the echogenicity of blood and the level of aggregation. RESULTS: For the four experiments reported, the power peaked at low shear rates probably because of increased RBC collisions and aggregation and then decreased thereafter because of disaggregation. The largest power variations were measured at shear rates of less than 40 seconds -1. At flow rates that varied between 75 and 500 mL/min, the echogenicity was low near the wall of the tube, increased toward the middle, and decreased at the tube center. The Doppler scan power was uniform across the tube at flow rates of 750 and 1000 mL/min. CONCLUSION: PDU is reliable to quantify the echogenicity of blood and the level of RBC aggregation. In comparison with other methods proposed to measure RBC aggregation, ultrasound scanning is applicable in vivo and may help to improve our basic understanding of the relationship between the hemodynamic of the circulation and RBC aggregation in human vessels.  (+info)

Effect of pressure on hydraulic conductivity of endothelial monolayers: role of endothelial cleft shear stress. (8/556)

Significant changes in transvascular pressure occur in pulmonary hypertension, microgravity, and many other physiological and pathophysiological circumstances. Using bovine aortic endothelial cells grown on porous, rigid supports, we demonstrate that step changes in transmural pressure of 10, 20, and 30 cmH(2)O induce significant elevations in endothelial hydraulic conductivity (L(p)) that require 5 h to reach new steady-state levels. The increases in L(p) can be reversed by addition of a stable cAMP analog (dibutyryl cAMP), and the increases in L(p) in response to pressure can be inhibited significantly with nitric oxide synthase inhibitors (N(G)-monomethyl-L-arginine and nitro-L-arginine methyl ester). The increase in L(p) was not due to pressure-induced stretch because the endothelial cell (EC) support was rigid. It is unlikely that the increase in L(p) was due to a direct effect of pressure because exposure of the cells to elevated pressure (25 cmH(2)O) for 4 h had no effect on the volume flux driven by a transmural pressure of 10 cmH(2)O. We hypothesize that elevated endothelial cleft shear stress induced by elevated transmural flow in response to elevated pressure stimulates the increase in L(p) through a nitric oxide-cAMP-dependent mechanism. This is consistent with recent studies of the effects of shear stress on the luminal surface of ECs. We provide simple estimates of endothelial cleft shear stress, which suggest magnitudes comparable to those imposed by blood flow on the luminal surface of ECs.  (+info)

HANDBOOK OF HEMORHEOLOGY AND HEMODYNAMICS PDF - Comparative hemorheology, in Handbook of Hemorheology and Hemodynamics, eds. O. K. Baskurt, M. R. Hardeman, M. W. Rampling, and. Article · January.
Hemorheology, also spelled haemorheology (from the Greek αἷμα, haima blood and rheology), or blood rheology, is the study of flow properties of blood and its elements of plasma and cells. Proper tissue perfusion can occur only when bloods rheological properties are within certain levels. Alterations of these properties play significant roles in disease processes. Blood viscosity is determined by plasma viscosity, hematocrit (volume fraction of red blood cell, which constitute 99.9% of the cellular elements) and mechanical properties of red blood cells. Red blood cells have unique mechanical behavior, which can be discussed under the terms erythrocyte deformability and erythrocyte aggregation. Because of that, blood behaves as a non-Newtonian fluid. As such, the viscosity of blood varies with shear rate. Blood becomes less viscous at high shear rates like those experienced with increased flow such as during exercise or in peak-systole. Therefore, blood is a shear-thinning fluid. ...
Authors: Shi, Y.D. , Agosti, R. , Ticozzelli, P. , Nasrawi, F. , Villa, S. , Somazzi, R. , Giovagnoni, M.G. , Longhini, E. Article Type: Research Article Abstract: Attention has been paid to the relationship between hypertension and hemorheology by several authors and their results showed that hypertension was associated with altered blood viscosity. The previous reports were empirically from one or several points of blood viscosity under different shear rates. Can we consider the pathogenesis from the whole curve of blood viscosity versus shear rate? Our aims are to use new concepts to reveal hemorheological properties and to analyze the pathological changes for essential hypertension by a Casson equation which summarize the whole curve of blood viscosity versus various shear rate. We use two parameters which are …derived from Casson equation and regressed from all the data of shear stress and shear rate, i. e. Casson yield stress and Casson viscosity, to describe the hemorheological changes ...
Authors: Totsimon, Kinga , Biro, Katalin , Szabo, Zsofia Eszter , Toth, Kalman , Kenyeres, Peter , Marton, Zsolt Article Type: Research Article Abstract: PURPOSE: The prognostic scoring systems for mortality of intensive care patients estimate clinical outcome using several physiological and biochemical parameters. In altered hemodynamic conditions of critically ill patients, hemorheological variables may play a significant role in appropriate tissue perfusion. We investigated if hemorheological parameters are altered in critical status and if they could be markers of mortality. METHODS: 112 patients (67.8 ± 12 years, 58 males, 54 females) treated in intensive care unit with different non-surgical diseases were investigated. Routine laboratory parameters and prognostic scores were determined and hemorheological variables (hematocrit, plasma and whole blood viscosity, red …blood cell aggregation and deformability) were measured on the 1st and the 2nd day after admission. RESULTS: ICU scores ...
This study aimed to investigate the relationship between endothelial nitric oxide synthase Glu(298)Asp gene polymorphism and hemorheological parameters. Red blood cell (RBC) deformability, aggregation were measured using an ectacytometry, whole blood, plasma viscosities were determined by a viscometer. Restriction fragment length polymorphism was used to detect polymorphism. Plasma nitrite, nitrate concentrations were determined by Griess method. The genotype distribution of the control group was as follows: 50 (67.5%) GG, 21 (28.4%) GT, 3 (4.1%) TT. A 48 (57.8%) of the patients with CAD had GG, 28 (33.7%) GT, 7 (8.5%) of them TT genotype. RBC aggregation index of CAD patients with G allele was higher and t1/2 lower compared to controls carrying the same allele. The amplitude of RBC aggregation of healthy subjects with T allele, who are under increased cardiovascular risk was lower compared to control subjects with G allele. The results of this study indicate that, alterations in RBC aggregation ...
Fingerprint Dive into the research topics of Changes in hemorheological parameters during physical exertion in coronary disease patients. Together they form a unique fingerprint. ...
Authors: Leterrier, F. , Saint-Blancard, J. , Stoltz, J.F. Article Type: Review Article Abstract: An enormous amount of work has been performed on the metabolic properties of the red blood cell during its storage in blood bank conditions, but the membrane structure changes (both at the molecular and at the macroscopic level) and the rheological perturbations of stored erythrocytes have been comparatively less well studied. In the last decade, the progress in our understanding of the organization and the properties of the red blood cell membrane has been considerable. It is thus interesting to review the work concerning the biophysical aspects of blood storage in the light of these recent findings. In a first …part, recent advances about the normal erythrocyte are summarized, emphasizing membrane structure and rheological properties. The reviewed literature is essentially limited to 1979-1981. The second part deals with the biological and rheological pertubations caused by storage of the blood ...
Jancsó, G., Arató, E., Hardi, P., Nagy, T., Pintér, Fazekas, G., Gasz, B., Takacs, I., Menyhei, G., Kollar, L. & Sínay, L., 2016, In : Clinical Hemorheology and Microcirculation. 63, 3, p. 217-234 18 p.. Research output: Article ...
Efforts to identify and visualize near-wall structures typically focus on the region y+≳5, where large-scale structures with significant turbulent kinetic energy content reside, such as the high-speed and low-speed streaks associated with sweep and ejection events. While it is true that the level of the turbulent kinetic energy drops to zero as one approaches the wall, the organization of near-wall turbulence does not end at y+≈5. Large-scale structures with significant streamwise extent and spatial organization exist even in the immediate proximity of the wall y+,5. These coherent structures have received less attention so far, but it would be both useful and enlightening to bring them to focus in order, on one hand, to understand them, but also to analyze their interaction with the energetic structures that reside at somewhat higher distances from the wall. We have recently developed a rigorous mathematical and computational framework that can be used for the calculation of the turbulence ...
TY - JOUR. T1 - Hemorheological parameters in coronary artery disease. AU - Kesmarky, G.. AU - Toth, K.. AU - Habon, L.. AU - Vajda, G.. AU - Juricskay, I.. PY - 1998/7/1. Y1 - 1998/7/1. N2 - Hemorheological parameters are primary risk factors in ischemic heart disease (IHD). In the present study the relation of these parameters to the severity of coronary artery disease (CAD) was examined. The data of 109 patients (mean age: 55 ± 9 years) undergoing coronary angiography and 59 healthy controls (mean age: 35 ± 10 years) were analyzed. Hemorheological parameters (hematocrit, fibrinogen level, plasma viscosity (PV) and apparent whole blood Viscosity (WBV)) were determined and the circulatory index (CRI) was calculated. Patients were classified into three groups according to their coronary vessel state based on the coronary angiogram: Group 1 (n = 19, mean age: 53 ± 8 years) without significant CAD, Group 2 (n = 19, mean age: 51 ± 11 years) with single vessel disease, Group 3 (n = 71, mean age: ...
Exchanges of water and electrolytes through biological membranes. Concentration and electrochemical gradients. Saline, isotonic and iso-osmotic solutions, and their use. Osmotic pressure: definition, units of measurements, plasma values. Vant Hoffs law, Gibbs-Donnan equilibrium. Hydrostatic pressure. Colloid osmotic and oncotic pressure: plasmas value and fluctuations. Consequences of oncotic pressure modifications. Starlings law and capillary exchanges. Edema.. PRINCIPLES OF HEMODYNAMICS AND HEMORHEOLOGY ...
Tilles AW, Eckstein EC. The near-wall excess of platelet-sized particles in blood flow: its dependence on hematocrit and wall shear rate. Microvasc Res. 1987 Mar; 33(2):211-23 ...
Atherosclerosis is initiated by endothelial injury that is related to abnormal values of hemodynamic parameters such as wall shear stress (WSS), oscillator
Culture a large number of endothelial cells under shear stress conditions in a FiberCell artificial capillary system (hollow fibre bioreactor cartridge).
TY - GEN. T1 - Discovery of side- and shear-dependent mirnas and mrnas in human aortic valvular endothelial cells. AU - Holliday, Casey J.. AU - Ankeny, Randall F.. AU - Jo, Hanjoong. AU - Nerem, Robert M.. PY - 2011/12/1. Y1 - 2011/12/1. UR - http://www.scopus.com/inward/record.url?scp=84881227089&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84881227089&partnerID=8YFLogxK. U2 - 10.1115/SBC2011-53315. DO - 10.1115/SBC2011-53315. M3 - Conference contribution. AN - SCOPUS:84881227089. SN - 9780791854587. SP - 235. EP - 236. BT - ASME 2011 Summer Bioengineering Conference, SBC 2011. T2 - ASME 2011 Summer Bioengineering Conference, SBC 2011. Y2 - 22 June 2011 through 25 June 2011. ER - ...
TY - JOUR. T1 - Isovolemic hemodilution in experimental focal cerebral ischemia. Part 1. T2 - Effects on hemodynamics, hemorheology, and intracranial pressure. AU - Tu, Y. K.. AU - Heros, R. C.. AU - Candia, G.. AU - Hyodo, A.. AU - Lagree, K.. AU - Callahan, R.. AU - Zervas, N. T.. AU - Karacostas, D.. PY - 1988/1/1. Y1 - 1988/1/1. N2 - A total of 76 splenectomized dogs were entered in a study of the value and effects of isovolemic hemodilution. Of these, seven were not included in the analysis because of technical errors. Of the remaining 69 dogs, 35 were treated with hemodilution; 28 were subjected to a 6-hour period of temporary occlusion of the distal internal carotid artery and the proximal middle cerebral artery, and seven underwent a sham operation only, with arterial manipulation but no occlusion. The other 34 dogs were not subjected to hemodilution; 26 of these underwent temporary arterial occlusion and eight had a sham operation only. In each group the animals were about equally ...
Authors: Vayá, Amparo , Murado, Julián , Santaolaria, Marisa , Simó, María , Micó, Luisa , Calvo, Javier , Todolí, José , Ricart, Jose M. Article Type: Research Article Abstract: Atherothrombotic events are significant factors of mortality and morbidity in patients with systemic lupus erythematosus (SLE). The extent that rheological factors may be involved in these events in these patients has not been established. We measured the following rheological parameters in 86 patients with SLE, of whom 16 had suffered venous and/or arterial thrombotic events, and in 86 healthy controls: fibrinogen (Fbg), plasma viscosity (PV), blood viscosity at 230 s−1 both at native haematocrit (BVn 230 s−1 ) and corrected to 45% (BVc 230 s−1 ), erythrocyte aggregation at stasis (AE0 ) and at 3 s−1 (AE1 ), …aggregation time (Ta), aggregation index at 10 s (AI10 ), disaggregation threshold (γD), and erythrocyte deformability (ED). In addition glucose, total cholesterol (T-Chol), triglycerides (TG), ...
View more ,Introduction: It has been shown that growth hormone (GH) exerts regulatory effects on hemorheology and other metabolic functions. GH stimulates the production of insulin-like growth factor I (IGF-I) and GH-IGF-I system has profound effects on body fluid status. There are speculations that GH has become widely used as a performance enhancing drug among athletes of various sports. The present study evaluated the possible hemorheological effects of short term administration of human recombinant growth hormone (rhGH) in healthy young males. Methodology: Thirty young healthy males (27 ᠹ) participated in a 29 days study where it was administered either 0.9% sodium chloride or 1 mg of human rhGH from day 1 to day 7. The participants were randomly assigned into either placebo (C) n = 15 or rhGH 1 mg/day (rhGH) group n = 15. This study evaluated plasma fibrinogen levels, red blood cell (RBC) aggregation, deformability and serum IGF-I levels between and within the groups along 29 days. ...
A numerical study of hemodynamic parameters of pulsatile blood flow is presented in a stenotic artery with non-Newtonian models using ADINA. Blood flow was considered laminar, and arterial wall was considered rigid. Studied stenosis severities were 30%, 50% and 70% of the cross-sectional area of the artery. Six non-Newtonian models were used to model the non-Newtonian behavior of blood, and their results were compared with the Newtonian model. The results showed that in Power Law and Walburn-Schneck models, unlike other models, shear stress values before and after the stenosis were smaller than Newtonian models. Also, in maximum flow rate, the Carreua, generalized Power Law, Casson, and Carreua-Yasuda models showed a reduction in global importance factor of non-Newtonian behavior, and as a result, the results approached Newtonian model. In minimum flow rate, the global importance factor of Newtonian behavior increased, which highlighted the importance of Newtonian model. In minimum flow rate, Carreua
A numerical study of hemodynamic parameters of pulsatile blood flow is presented in a stenotic artery with non-Newtonian models using ADINA. Blood flow was considered laminar, and arterial wall was considered rigid. Studied stenosis severities were 30%, 50% and 70% of the cross-sectional area of the artery. Six non-Newtonian models were used to model the non-Newtonian behavior of blood, and their results were compared with the Newtonian model. The results showed that in Power Law and Walburn-Schneck models, unlike other models, shear stress values before and after the stenosis were smaller than Newtonian models. Also, in maximum flow rate, the Carreua, generalized Power Law, Casson, and Carreua-Yasuda models showed a reduction in global importance factor of non-Newtonian behavior, and as a result, the results approached Newtonian model. In minimum flow rate, the global importance factor of Newtonian behavior increased, which highlighted the importance of Newtonian model. In minimum flow rate, Carreua
Within the present investigation, a miniature viscous disk pump (VDP) is utilized to characterize and quantify non-Newtonian fluid elastic turbulence effects, relative to Newtonian flow behavior. Such deviations from Newtonian behavior are induced by adding polyacrylamide to purified water. The VDP consists of a 10.16 mm diameter disk that rotates above a C-shaped channel with inner and outer radii of 1.19 mm and 2.38 mm, respectively. A channel depth of 230 μm is employed. Fluid inlet and outlet ports are located at the ends of the C-shaped channel. Experimental data are given for rotational speeds of 126 1/s, 188 1/s, 262 1/s, and 366 1/s, pressure rises as high as 700 Pa, and flow rates up to approximately 0.00000005 m3/s. Reynolds number ranges from 2.9 to 6.5 for the non-Newtonian polyacrylamide solution flows and from 51.6 to 149.8 for the Newtonian pure water flows. To characterize deviations due to non-Newtonian elastic turbulence phenomena, two new parameters are introduced, PrR and ...
RBC aggregation is a major determinant of blood viscosity, particularly under the conditions of low shear stress, and therefore it affects blood flow dynamics mainly within the microcirculation, where such conditions prevail [9]. Experimental models and clinical studies demonstrate the potential of RBC aggregation to hinder blood flow through the microcirculation in various diseases [1]. The formation of sludge blood under these conditions is assumed to cause tissue hypoxia and acidosis, and to lead to the met- abolic disturbances. A pathogenic role for erythrocyte aggregation has been postulated in acute coronary syn- dromes [2,6]. These studies examined the blood viscosity, not the erythrocyte aggregation, which seems to be most important from our standpoint. Furthermore, we mentioned the importance of the erythrocyte aggregation for the vessels injury. Rheological disorders allow atherogenic particles to be longer exposed to the vascular endothelial and consequently greater interaction ...
The acute and chronic adaptation to changes in blood flow occur as a result of endothelium-dependent responses that regulate vascular tone and the organization of the blood vessel wall. Among the most rapid responses of vascular endothelial cells to changes in fluid shear stress are K+ channel activation,2 generation of inositol trisphosphate,3 an increase in [Ca2+]i,23 24 and changes in pHi.4 5 The present study shows that an abrupt decrease in fluid shear stress produces cytosolic alkalinization of vascular endothelial cells by affecting membrane ion transporters that contribute to pHi regulation. After a period of exposure to continuous fluid shear stress at 2.7 dyne/cm2, the abrupt reduction of fluid shear stress from 2.7 to 0.3 dyne/cm2 produced a bicarbonate-dependent increase in pHi of 0.27 pH unit, which was not affected by prior inhibition of the Na+-H+ exchanger alone. Recovery from an NH4Cl prepulse-induced acid load occurred more rapidly when fluid shear stress was abruptly reduced ...
The significance of non-Newtonian hemodynamics of small blood vessels is addressed via the description and critical discussion of cogent models within Computational Fluid Dynamics (CFD) software, in this case ANSYS-CFX. Several applicable hemodynamical shear-thinning models are presented and the relevance with respect to prediction of Shear Strain Rate (SSR) rigorously examined, in order to critically evaluate salient literature. It is found that the small vessels explored, in line with the aforementioned literature, that non-Newtionian evaluation of the fluid behavior is indeed negligible. The work presented herein is a precursor to investigation of more complex geometries and hemodynamic simulations, which are being actively researched. This is a technical note which attempts to address the significance of Newtonian/non-Newtonian flows in small blood vessels.. ...
TY - JOUR. T1 - Effects of disturbed flow on endothelial cells. AU - Chiu, J. J.. AU - Wang, D. L.. AU - Usami, S.. AU - Chien, S.. AU - Skalak, R.. PY - 1998/2. Y1 - 1998/2. N2 - Atherosclerotic lesions tend to localize at curvatures and branches of the arterial system, where the local flow is often disturbed and irregular (e.g., flow separation, recirculation, complex flow patterns, and nonuniform shear stress distributions). The effects of such flow conditions on cultured human umbilical vein endothelial cells (HUVECs) were studied in vitro by using a vertical-step flow channel (VSF). Detailed shear stress distributions and flow structures have been computed by using the finite volume method in a general curvilinear coordinate system. HUVECs in the reattachment areas with low shear stresses were generally rounded in shape. In contrast, the cells under higher shear stresses were significantly elongated and aligned with the flow direction, even for those in the area with reversed flow. When ...
Overview. Bacterial adhesion and subsequent colonization of surfaces are the first steps toward forming biofilms, which are a major concern for implanted medical devices and in many diseases. Biofilms are resistant to innate host defences, mechanical removal and antibiotic treatments. It is therefore important to understand the physiological environment and mechanisms that lead to the spread of bacteria. Experimental conditions of biofilm formation on cardiovascular stents, tubing, different surfaces and in the intestines can easily be studied using Cellixs microfluidic pumps and biochips. The dimensions of the biochips facilitate both high and low shear stress conditions. The microcapillary walls of Cellixs biochips may be pre-coated with proteins of interest to promote adhesion and culture of biofilms under different shear stress conditions. Once the biofilm is cultured, it is then possible to flow different substances (e.g. antibiotics) over the biofilm to investigate detachment. There are ...
Non-Newtonian and Newtonian blood flow in human aorta: A transient analysis, Kumar D, Vinoth R, Raviraj Adhikari, Vijay Shankar CS
The fascinating phenomenon of a leaping shampoo stream, Kaye effect, is a property of non-Newtonian fluid which was first described by Alan Kaye in 1963. It manifest itself, when a thin stream of non-Newtonian fluid is poured into a dish of the fluid. As pouring proceeds, a small stream of liquid occasionally leaps upward from the heap and bounces. In earlier studies, it is known that the reason for bouncing Newtonian jet is the lubricating air layer but for Non-Newtonian jet, the Kaye effect, it has been debated whether non-Newtonian effects are the underlying cause of this phenomenon, making the jet glide on top of a shear-thinning liquid layer, or whether an entrained air layer is responsible. Since there is no mathematical model or numerical simulation studied before for these bouncing jets, as a first approach, we have studied a mathematical model and algorithm to show that the jet slides and bounces on a lubricating air layer and to find the range of parameters to observe the Kaye effects. ...
In this paper, the power-law model for a non-Newtonian (pseudo-plastic) flow is investigated numerically. The D2Q9 model of Lattice Boltzmann method is used to simulate the micro-channel flow with expansion geometries. This geometry is made by two squared ...
Sermion (Nicergolinum, Nicergoline) the drug improving a cerebral and peripheral circulation, an alpha-blocker. Nicergoline - ergoline derivative improves hemodynamic and metabolic processes in the brain. It reduces platelet aggregation and improves hemorheological parameters of blood, increases the rate of blood flow in the upper and lower limbs, has alpha1-adrenoceptor blocking action.
The main objective of the present study is to predict characteristics of three dimensional pulstitile flow by location of stenosis in blood vessel with the second order bifurcation. The present study simulates the incompressible non-Newtonian laminar blood flows using a Fluent V. 6.0. The Carreau mo...
A perfusion system to cultivate cells under physiological conditions | Simulation of blood vessels for endothelial cell culture | Different shear stress conditions
Presentation Summary Industrial heating methods Direct steam injection (DSI) basics Inherent properties for sustainability Case Studies - Thanks to all of you for the opportunity to speak with you regarding direct steam injection this afternoon. Ill begin with presenting the basics of direct verses indirect heating using conventional sludge heat exchangers as a reference point for presenting the benefits of DSI. Ill review internal modulation verses external modulation. Cover the advantages of DSI using hot water heat exchangers as a reference point. Ill show various digestion heating flow schemes using DSI. Present typical DSI heater dimensions and installations. Followed by specific digester benefits that can be realized with DSI and conclude with a summary and questions and answers.
DAUERSCHALLVERFAHREN, DOPPLERVERFAHREN (MEDIZINISCHE DIAGNOSTIK); HÄMORHEOLOGIE, HÄMODYNAMIK, BLUTSTRÖMUNG, DURCHBLUTUNG (PHYSIOLOGIE); DOPPLER ULTRASONIC DIAGNOSTICS (MEDICAL DIAGNOSTICS); HAEMORHEOLOGY, HAEMODYNAMICS, BLOOD FLOW, BLOOD PERFUSION (PHYSIOLOGY ...
Our Books Steve Hickey and Hilary Roberts (2004) Ascorbate: The Science of Vitamin C, Lulu press. Dare I say, the most important development in the history of vitamin C? John Ely, University of Washington, June 22, 2004 The theory proposed, the Dynamic Flow Model, is the most important development in the history of vitamin C. - The…
GO:0034405. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. ...
Today I learned Ketchup is a non-Newtonian fluid, and the best way to get Heins ketchup out of a glass jar is to hit near the mouth, not the bottom of the bottle. (Actually I find sticking a knife and pulling it out to be even more effective ...
A child, at first, is self-aware, believing that if she is unhappy, the whole world is unhappy. She discovers her toes as a distinguishable part and her surroundings as distinguishable things apart. During development, she passes through predictable stages of close identification with an immediate group, compliance for award or punishment-avoidance, respectful compliance to established authorities, competing for personal achievement, suppression of self for group unity, fitting to the dynamic flow of life, committing to higher abstract values. Communities, civilizations, and societies also grow through similar stages. Not every entity will progress continuously, but may stall and remain at some level. Each level adapts a different view of what is sacred and thus gives meaning to life ...
A 100 fold range of shear stress (.04-4 dynes/cm$\sp2$) was used to demonstrate that the level of shear used in conjugate enumeration assays affects the absolute magnitude of CTL-TC conjugates observed. Kinetic analysis ...
Rheology - the study of the flow of matter and accompanying phenomena of real bodies deformation - in relation to blood - hemorheology. Blood viscosity - the main rheological parameter - has been studied in many research centers and among many different group of patients. The main disorders related to the hemorheological properties are: coronary insufficiency, vascular congestion, myocardial infarction, cerebral circulation disorder, Reynaud disease, ischemic limbs, diabetes, anemia, tumors. The following parameters are the main blood viscosity determinants: plasma viscosity, hematocrit, red cell deformability and erythrocytes aggregation. In hemorheological studies we used mathematical rheological models. The measurements of blood and plasma viscosity are performed by means of oscillating-rotary rheometers in order to determine the dependence of blood viscosity on the shear rate and the two components of the complex blood viscosity. Determination of blood cells aggregability and deformability ...
In this work, non-Newtonian effects on Low-Density Lipoprotein (LDL) transport across an artery are analyzed with a multi-layer model. Four rheological models (Carreau, Carreau-Yasuda, power-law and Newtonian) are used for the blood flow through the lumen. For the non-Newtonian cases, the arterial wall is modeled with a generalized momentum equation. Convection-diffusion equation is used for the LDL transport through the lumen, while Staverman-Kedem-Katchalsky, combined with porous media equations, are used for the LDL transport through the wall. Results are presented in terms of filtration velocity, Wall Shear Stresses (WSS) and concentration profiles. It is shown that non-Newtonian effects on mass transport are negligible for a healthy intramural pressure value. Non-Newtonian effects increase slightly with intramural pressure, but Newtonian assumption can still be considered reliable. Effects of arterial size are also analyzed, showing that Newtonian assumption can be considered valid for both ...
View more ,Impaired heart rate variability (HRV)and haemorheology are independently associated with cardiovascular disease and diabetic complications. The aim of the present study was to investigate the relationships between parameters of HRV,and red blood cell (RBC) aggregation and deformability, in older women with type 2 diabetes. Twenty women (age 69 ᠲ yr) with uncomplicated type 2 diabetes and twenty controls (age 69 ᠳ yr) participated in the study. Beat-to-beat cardiac (RR) intervals over 5 min were analysed for HRV parameters in the time and frequency domains. Blood was sampled for RBC deformability, as well as RBC aggregation in two suspending mediums: haematocrit adjusted plasma and 3% dextran 70. RBC aggregation was increased and HRV was impaired for those with type 2 diabetes when compared with control. RBC aggregation was negatively related to low frequency power of HRV, and was positively related to high frequency power of HRV, for subjects with type 2 diabetes. RBC ...
In this work, the fluid flow over a 2D backward-facing step is analyzed in order to provide a case study for the use of different models for the blood dynamic viscosity in COMSOL Multiphysics. Three non-Newtonian models, as well as the Newtonian model are used to study the shear stresses and the reattachment length as a function of the fluid speed. The non-Newtonian models used in this study are the Carreau model, the power law model, and one of its variants, the Walburn-Schneck model. For the models studied, a transition from a Newtonian to a non-Newtonian behavior is observed as the center line speed is decreased.. ...
Lu, Yiling and Li, Wei-Qi and Oraifige, I. and Wang, Wen (2014) Converging parallel plate flow chambers for studies on the effect of the spatial gradient of wall shear stress on endothelial cells. Journal of Biosciences and Medicines, 2. pp. 50-56. ISSN 2327-5081 ...
The pathogenic potential of RBC aggregation within the microcirculation is dependent on the extent of RBC aggregation and the cohesive forces within the aggregate (i.e., the resistance of aggregates to shear-induced disaggregation).25 This increase of the required shear forces might have important physiological consequences, especially at the microcirculatory level, since RBC are only able to pass through small capillaries as single cells.5 However, since γmin for SCA and SCC patients were similar, differences of blood viscosity and RBC deformability between the two groups probably play a role in their unequal clinical severity.26. Although the forces required to disperse preformed RBC aggregates are elevated in SCA and SCC subjects, the extent of aggregation at stasis (i.e., AI) was lower than control in both groups; this finding contrasts with results obtained by Obiefuna et al.27 on SCA patients but is consistent with results obtained by Chien et al.2 The reasons for the discordant results ...
While there is growing experimental evidence that cerebrospinal fluid (CSF) flow induced by the beating of ependymal cilia is an important factor for neuronal guidance, the respective contribution of vascular pulsation-driven macroscale oscillatory CSF flow remains unclear. This work uses computational fluid dynamics to elucidate the interplay between macroscale and cilia-induced CSF flows and their relative impact on near-wall dynamics. Physiological macroscale CSF dynamics are simulated in the ventricular space using subject-specific anatomy, wall motion and choroid plexus pulsations derived from magnetic resonance imaging. Near-wall flow is quantified in two subdomains selected from the right lateral ventricle, for which dynamic boundary conditions are extracted from the macroscale simulations. When cilia are neglected, CSF pulsation leads to periodic flow reversals along the ventricular surface, resulting in close to zero time-averaged force on the ventricle wall. The cilia promote more ...
Usually, when calculating the blood flow in cerebral arteries and intracranial aneurysms, blood is modeled as a Newtonian fluid, neglecting its shear-thinning behavior. Since flow diverting devices slow down the blood flow in the aneurysm sack, the accuracy of this assumption had to be reviewed. A Carreau Yasuda model is introduced as a non-Newtonian model for blood viscosity. CFD simulations of an intracranial sidewall aneurysm treated with an endovascular device using a Newtonian and the non-Newtonian model have been performed and the results of the comparison between the blood viscosity models are presented. Our example found the Newtonian model overestimating the effect of the flow diverting stent by up to 6%, thus, it seems not to be sufficient for calculations past endovascular devices.. ...
This study was designed to elucidate the expression of renal tissue cytokines by receiving concomitant ECMO and CRRT in the healthy swine model. Our results showed that it might remove ECMO-induced cytokines, maintain the role of immune equilibrium, reduce the extent of ECMO-related SIRS, thereby leading to improve ECMO-related acute renal dysfunction.. CRRT was applied to acute renal failure patients have been widely recognized. CRRT matched with human kidney by continuously, slowly and convection running. Its mainly advantage is that it could stabilize the hemodynamic, improve azotemia, electrolytes and water-salt metabolism, keep on cleaning cycle of all sorts of cytokines and improve nutrition [10-13].. Previous animal experiments and clinical studies have shown that blood components are continually exposed to non-biological artificial surface from cardiopulmonary bypass pipe and changes of the non-physiological hemorheology during ECMO running. This leads to the complement system, the ...
United States Patent C) US. Cl. 252-33 16 Claims ABSTRACT OF THE DISCLOSURE Compositions characterized by improved rheological properties comprising a material capable of possessing thixotropic or pseudoplastic properties and non-Newtonian colloidal disperse systems. These systems are characterized as colloidal dispersions of solid, metal-containing colloidal particles predispersed in an inert organic liquid and, as an essential third component of the system, an organic compound with molecules which contain a hydrophobic portion and at least onepolar substituent. A typical composition contains polyvinylchloride polymer, a plasticizer for the polymer, and a disperse system comprising calcium carbonate particles, a liquid hydrocarbon dispersing medium, and a calcium petrosulfonate. A method for imparting improved rheological properties to materials susceptible to possessing such properties by incorporating therein these disperse systems is described as are novel non-Newtonian disperse systems per ...
Global Blood Viscometer Market By Product Type (Rotational Viscometer, Capillary Viscometer) And By End-Users/Application (Hospital, Clinic) Global Market Share, Forecast Data, In-Depth Analysis, And Detailed Overview, and Forecast, 2013 - 2026
hi all i want to write a udf for non-newtonian viscosity. i have viscosity-shear rate plot corrosponding temprature. please help me more in writing udf in section viscosity in material panel. thanks alot ...
Hi every body I have Written an UDF for non-Newtonian Fluid, but it doesnt work in both series and parallel fluent run.the code is: #include udf
Viscometer / Viscosity Meter PCE-RVI 4 VP20 . PCE-RVI 4 VP20 is a rotational viscometer used in industrial and research applications to measure viscosity according to the Brookfield method. Featuring a simple, lightweight construction for ease of portability, this digital viscometer can be used in
This video demostration explains how to use the BV1 Single Sample Viscometer and explains the key features that make it perfect for remote sample analysis. The capilliary viscometer can analyze plasma samples stored in EDTA without removing the cap, even if the sample has been previously used for other analyses. The viscometer utilizes only 50-80 µl of plasma per analyses, allowing repeat testing for pediatric and adult samples.
M. M. R. F, E. E. K and R. W. D.-The data presented in the attached Figs. 1, 2, and 3 show that the two viscometers yield values of about the same precision and reproducibility. To compare the results from the two different instruments, an average rate of shear must be assigned to the capillary type of viscometer. Values ranging from 0.5 to 0.66 of the maximum rate of shear at the capillary wall have been used as the average rate of shear. This basis appears adequate for the present comparisons given in Figs. 1, 2, and 3. Considering all the variables involved, the differences in equipment and in techniques, and the number of experimental points covered in the two studies, the agreement between the two instruments is good; the maximum difference is about 6 percentage units in viscosity decrease. The agreement between the two instruments is poorest at +210 F with both oils. The best agreement for oil No. 104 is at 150 F and for oil No. 103 at 100 F. ...
cells with GpIba receptors in their membranes and platelets formed long beads-on-a-string formations on the endothelial culture cells when exposed to ultra large von Willebrand factor (ULVWF) multimers under high shear stress conditions.. When blood from a patient with TTP is tested using the Impact-R, surface coverage and aggregate size are expected to be large because of the presence of ULVWF in the patients plasma. When the same blood is exposed to plasma from a normal patient (which contains ADAMTS-13), and then tested by the Impact-R, theoretically, there will be a lessening of the surface coverage and aggregate size. This is the subject of a study by Shenkman in which he proposed that Impact-R could be used as a rapid screening test for TTP.. ...
High Temperature Viscometer in West Bengal India - Manufacturer & Exporters of High Temperature Viscometer offered by Delta Scientific Equipment Pvt. Ltd., India | ID - 784447
Here, the constant η is known as the coefficient of viscosity, the viscosity, the dynamic viscosity, or the Newtonian viscosity. Many fluids, such as water and most gases, satisfy Newtons criterion and are known as Newtonian fluids. Non-Newtonian fluids exhibit a more complicated relationship between shear stress and velocity gradient than simple linearity. The relationship between the shear stress and the velocity gradient can also be obtained by considering two plates closely spaced apart at a distance y, and separated by a homogeneous substance. Assuming that the plates are very large, with a large area A, such that edge effects may be ignored, and that the lower plate is fixed, let a force F be applied to the upper plate. If this force causes the substance between the plates to undergo shear flow (as opposed to just shearing elastically until the shear stress in the substance balances the applied force), the substance is called a fluid. The applied force is proportional to the area and ...
Cellular functions related to the maintenance of homoeostasis are regulated by shear forces sensed by endothelial cells. The endothelial cells sense local changes in shea..
Topics: GEFÄSSPROTHESEN (MEDIZIN); ANIMAL MODELS IN MEDICINE; VASCULAR PROSTHESES (MEDICINE); HAEMORHEOLOGY, HAEMODYNAMICS, BLOOD FLOW, BLOOD PERFUSION (PHYSIOLOGY); TIERISCHE MODELLE IN DER MEDIZIN; HÄMORHEOLOGIE, HÄMODYNAMIK, BLUTSTRÖMUNG, DURCHBLUTUNG (PHYSIOLOGIE); TARGETED DRUGS (PHARMACOLOGY); MODELLRECHNUNG UND SIMULATION IN DER PHYSIOLOGIE; HERZKRANZGEFÄSSE (ANATOMIE UND PHYSIOLOGIE); MATHEMATICAL MODELING AND SIMULATION IN PHYSIOLOGY; CORONARY VESSELS (ANATOMY AND PHYSIOLOGY); ZIELGERICHTETE ARZNEIMITTEL (PHARMAKOLOGIE), info:eu-repo/classification/ddc/610, Medical sciences, medicine ...
The rolling-ball viscometer Lovis 2000 M/ME measures the rolling time of a ball through transparent and opaque liquids according to Hoepplers falling ball principle.
The rolling-ball viscometer Lovis 2000 M/ME measures the rolling time of a ball through transparent and opaque liquids according to Hoepplers falling ball principle.
Analis biedt een complete service voor de reparatie en ijking van Brookfield viscosimeters, thermische baden en toebehoren. Een team gekwalificeerde en ervaren technici werkt vanuit onze goed uitgeruste serviceafdeling. Elk apparaat wordt zorgvuldig gecontroleerd voor maximale betrouwbaarheid en nauwkeurigheid, inclusief vervanging van jewel support bearing (steunlager) en pivot point (draaipen). De ijking wordt uitgevoerd met oliën conform de internationale normen (National Institute of Standards & Technology, VS). Wanneer uw apparaat hersteld wordt, kunt u een vervangingsapparaat huren (indien voorradig). Voor een snelle en efficiënte bijstand worden alle informatie- en serviceaanvragen behandeld door onze servicecoördinator ...
Ukropec, Jon A., Fluid shear stress-induced reorganization of adherens junctions in human endothelial cells (1999). Theses. 24 ...
Topics will include: aerosols transport, functional respiratory imaging, fluid dynamics of airway and lung disorders, respiratory fluid dynamics (including treatment), fragmentation and breakup mechanisms of non-Newtonian liquids with relevance to coughing, sneezing and droplets spreading ...
PhD v d s. Dr. T tsimon Kinga „Hemorheological investigations in carotid artery stenosis and in critically ill patients c m PhD rtekez s nek 2017. febru r 22- n (szerda) 11 rakor a PTE OK Dr. Entz B la Klinikai Oktat si K zpontj ban (P cs, Ifj s g t 13. K002 terem) tartand nyilv nos vit ja.. A Bizotts g sszet tele:. eln k:. Dr. Koll r Lajos Ph.D egyetemi tan r (PTE OK). tagok:. Dr. Arat Endre Ph.D egyetemi docens (PTE OK). Dr. Kom csi Andr s D.Sc egyetemi docens (PTE OK). opponensek:. Dr. Nagy Lajos Ph.D f igazgat f orvos (Szombathely). Dr. N meth Norbert Ph.D egyetemi docens (DE). ...
Rheology concerns itself with materials that have aspects of both solids and liquids, and researches the flow and deformation of matter. Malvern Instr
A liquid crystal-based photochromic coating was formulated to enable direct visualization of shear stress in flowing blood. The coating was comprised of a low d...
Hemorheology, also spelled haemorheology (from the Greek αἷμα, haima "blood" and rheology), or blood rheology, is the study of ... T. How, Advances in Hemodynamics and Hemorheology Vol. 1, JAI Press LTD., 1996, 1-32. R. Bird, R. Armstrong, O. Hassager, ... Alfred L. Copley, the scientist who introduced the term hemorheology.[citation needed] Blood hammer Biorheology, the study of ... Baskurt, OK; Hardeman M; Rampling MW; Meiselman HJ (2007). Handbook of Hemorheology and Hemodynamics. Amsterdam, Netherlands: ...
Buy Hemorheology in Practice by John F. Stolz, etc. from Waterstones today! Click and Collect from your local Waterstones or ... Hemorheology in Practice - Biomedical and Health Research v. 30 (Hardback). John F. Stolz (editor), etc. (editor) Sign in to ...
From a review of the literature of blood flow it is concluded that the physical properties of blood from different animals are very similar and that its basic rheology is reasonably well understood, except for minor uncertainties regarding the effect
Bioinformatics community open to all people. Strong emphasis on open access to biological information as well as Free and Open Source software.
Endothelium and hemorheology Issue title: 31 Years of Clinical Hemorheology and Microcirculation ... Journal: Clinical Hemorheology and Microcirculation, vol. 53, no. 1-2, pp. 3-10, 2013 ...
Effects of Batroxobin on the Hemorheology in Nude Mire with Gastric and Nasopharyngeal Carcinoma. BAN Xing-min, ZHOU Lei, HUANG ... Influence of Chronic Overdrinking on Relevat Hemorheology Indexes. HU Bi-ying (Chimeal Laboratory, Rudong Yraditional Chinese ...
THE SIGNIFICANCE OF BLOOD HEMORHEOLOGY IN REFLECTING BIOLOGICAL ACTION OF GASTRIC CANCER. Li Yufen Qi Qi Qixue (First hospital ...
Effects of different fluid resuscitation methods on hemorheology in pigs during burn shock stage were found in PRIME PubMed. ... Effects of Different Fluid Resuscitation Methods On Hemorheology in Pigs During Burn Shock Stage]." Zhonghua Yi Xue Za Zhi, vol ... Effects of Different Fluid Resuscitation Methods On Hemorheology in Pigs During Burn Shock Stage]. Zhonghua Yi Xue Za Zhi. 2019 ... Effects of different fluid resuscitation methods on hemorheology in pigs during burn shock stage]. Zhonghua Yi Xue Za Zhi. 2019 ...
Blood hemorheology is an integrated branch of physics and medicine. Increased blood viscosity is a risk factor for thrombosis, ... Effects on hemorheology. Hemorheological parameters were analyzed by routine laboratory assays. The results are shown in Table ... The aim of the present study was to evaluate the effects of AEE on platelet aggregation, hemorheology, blood biochemistry and ... Different drug effects on platelet aggregation, hemorheology, TXB2/6-keto-PGF1α ratio and blood biochemistry were studied. ...
Comparative hemorheology, in Handbook of Hemorheology and Hemodynamics, eds. O. K. Baskurt, M. R. Hardeman, M. W. Rampling, and ... and methods in hemorheology and hemodynamics. Sections of the Handbook include History of Hemorheology; Hemorheology, covering ... Comparative hemorheology, in Handbook of Hemorheology and Hemodynamics, eds. O. K. Baskurt, M. R. Hardeman, M. W. Rampling, and ... Ebook: Handbook of Hemorheology and Hemodynamics. Furthermore, the blood must circulate above a limiting rate if it is to do ...
Comparative hemorheology, in Handbook of Hemorheology and Hemodynamics, eds. O. K. Baskurt, M. R. Hardeman, M. W. Rampling, and ... Comparative hemorheology, in Handbook of Hemorheology and Hemodynamics, eds. O. K. Baskurt, M. R. Hardeman, M. W. Rampling, and ... Sections of the Handbook include History of Hemorheology; Hemorheology, covering basic aspects, blood composition, blood ... Hemorheology of the Fetus and Neonate. This body of research has revealed that blood trauma is related to non-physiological ...
Keywords: hemorheology, viscosity, red blood cells (RBC) Abstract. The blood transport dysfunction in case of various diseases ... Kozlovskii, Y. K. (2017). Fundamentals of hemorheology. Biomedical and Biosocial Anthropology, (24), 176-179. Retrieved from ... hemorheology. The method of the blood viscosity measurement is the most common in haemorheologic researches. Except the ...
Clinical Hemorheology and Microcirculation - Volume 31, issue 2. Purchase individual online access for 1 year to this journal. ... Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding ... Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the ... The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together ...
Keywords: Myocardial reperfusion, hemorheology, hemodilution, Danshen Citation: Clinical Hemorheology and Microcirculation, vol ... Keywords: Hypertension, pharmacological treatment, hemorheology Citation: Clinical Hemorheology and Microcirculation, vol. 17, ... Clinical Hemorheology and Microcirculation - Volume 17, issue 3. Purchase individual online access for 1 year to this journal. ... Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding ...
Hemorheology Language: English Journal: Korean Circulation Journal Year: 2011 Type: Article ... Hemorheology Language: English Journal: Korean Circulation Journal Year: 2011 Type: Article ... Hemorheology , Hydrodynamics , Microvascular Angina , Microvessels , Perfusion , Rheology , Vascular Diseases , Viscosity ...
Cigarette Smoking, Hemodynamics and Hemorheology. * Cigarette Smoking Causes Acute Changes in Arterial Wall Mechanics and the ...
Clinical Hemorheology and Microcirculation. Clinical Hemorheology and Microcirculation, a peer-reviewed international ... Celebrating 31 years of Clinical Hemorheology and Microcirculation journal. December 20, 2012 - Anniversary issue published ...
50. Hemorheology and Hemodynamics. Oguz K. Baskurt,Herbert J. Meiselman. Preview Price : US$7.50 ...
Hemorheology -- WG 106 *Hemostatic Disorders -- WH 312 *Hermeneutics *Hyperostosis -- WE 225 *Hyperostosis, Cortical, ...
"Clinical Hemorheology and Microcirculation. 64 (4): 541-549. doi:10.3233/CH-168031. ISSN 1875-8622. PMID 27791994. S2CID ...
... including hemorheology, microcirculation, coagulation, kidney filtration and dialysis, offering a historical overview of each ...
Hemorheology. Blood Circulation. Regional Blood Flow. Microcirculation. Exercise. Physical Fitness. Exercise Test. Sedentary ...
Clinical, hemorheology, TCD and ABR features in senile sudden deafness Clinical, hemorheology, TCD and ABR features in senile ... Objective To investigate the clinical, hemorheology, transcranial Doppler (TCD) and auditory brainstem evoked response (ABR) ... features in senile sudden deafness.Methods The clinical manifestations, hemorheology, TCD, and ABR data in 82 patients with ...
Forst T, Kunt T. Effects of C-peptide On Microvascular Blood Flow and Blood Hemorheology. Exp Diabesity Res. 2004;5(1):51-64. ... Effects of C-peptide on microvascular blood flow and blood hemorheology.. Exp Diabesity Res 2004 Jan-Mar; 5(1):51-64ED ... Forst T, Kunt T. Effects of C-peptide on microvascular blood flow and blood hemorheology. Exp Diabesity Res. 2004;5(1):51-64. ... TY - JOUR T1 - Effects of C-peptide on microvascular blood flow and blood hemorheology. AU - Forst,T, AU - Kunt,T, PY - 2004/6/ ...
Mesielman HJ (1993). "Red blood cell role in RBC aggregation: 1963-1993 and beyond". Clinical Hemorheology. 13: 575-592. Neu B ... 2009). "Comparison of three instruments for measuring red blood cell aggregation". Clinical Hemorheology and Microcirculation. ... Clinical Hemorheology. 7: 71-91. Chien S, Jan KM (1973). "Ultrastructural basis of the mechanism of rouleaux formation". ...
Hemorheology: principles and concepts --. Atherosclerosis and thrombosis in diabetes mellitus: new aspects of pathogenesis --. ... Hemorheology: principles and concepts -- Atherosclerosis and thrombosis in diabetes mellitus: new aspects of pathogenesis -- ...
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Part 1: Effects on hemodynamics, hemorheology, and intracranial pressure. Y. K. Tu, R. C. Heros, G. Candia, A. Hyodo, K. Lagree ... Part 1 : Effects on hemodynamics, hemorheology, and intracranial pressure. / Tu, Y. K.; Heros, R. C.; Candia, G.; Hyodo, A.; ... Part 1: Effects on hemodynamics, hemorheology, and intracranial pressure, Journal of Neurosurgery, vol. 69, no. 1, pp. 72-81. ... Part 1: Effects on hemodynamics, hemorheology, and intracranial pressure. Journal of Neurosurgery. 1988 Jan 1;69(1):72-81. ...
Hemorheology * Implants, Experimental * Intracranial Aneurysm / blood* * Intracranial Aneurysm / physiopathology * Intracranial ...
  • Clinical Hemorheology and Microcirculation , a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. (semcs.net)
  • The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. (semcs.net)
  • The editors of Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. (semcs.net)
  • Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. (semcs.net)
  • This book illustrates applications of mathematics to various processes (physiological or artificial) involving flowing blood, including hemorheology, microcirculation, coagulation, kidney filtration and dialysis, offering a historical overview of each topic. (springer.com)
  • Clinical Hemorheology and Microcirculation, issue 64/4, 2017. (europa.eu)
  • Clinical Hemorheology and microcirculation 17 (1997) 181-186. (sylvester.org)
  • Comparative hemorheology, in Handbook of Hemorheology and Hemodynamics, eds. (thecardiffkook.info)
  • Handbook of Hemorheology and Hemodynamics - Ebook download as PDF File .pdf), Text File .txt) or read book online. (thecardiffkook.info)
  • Since many aspects of hemorheology and hemodynamics are affected by disease or clinical states, these effects are discussed as are hyperviscosity syndromes, therapy for disturbed blood rheology, and methods in hemorheology and hemodynamics. (thecardiffkook.info)
  • In selecting topics for this handbook the editors have attempted to provide a general overview of both basic science and clinical hemorheology and hemodynamics. (thecardiffkook.info)
  • Hemorheology and hemodynamics are closely related, the former dealing with all aspects of the flow and interactions of the individual blood cells mostly studied in vitro, the latter with the in vivo relationships among vessel architecture, driving pressure, flow rate and shear stress. (thecardiffkook.info)
  • Abstract Circulating leukocytes and platelets must adhere to the wall of blood vessels in order to carry out ahd protective function of immunity for leukocytes and hemostasis for platelets: Since many aspects of hemorheology and hemodynamics are affected by disease or clinical states, these effects are discussed as are hyperviscosity syndromes, therapy for disturbed blood rheology, and methods in hemorheology and hemodynamics. (mariobet.mobi)
  • Handbook of Hemorheology and Hemodynamics , (pp. 228-241). (edu.au)
  • Handbook of Hemorheology and Hemodynamics , (pp. 371-391). (edu.au)
  • The hemorheology of these blood cells is unique in that these cells exist in a fluid phase subjected to variable, and often extreme, rheological shear stress, viscosity changes and biomechanical obstacles (e.g., capillaries and splenic filtration). (intechopen.com)
  • 1 Hemorheology is concerned with the dynamics of deformability. (who.int)
  • and Clinical Aspects of Hemorheology, covering hyperviscosity, clinical significance and treatment. (thecardiffkook.info)
  • Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features. (semcs.net)
  • Objective To investigate the clinical, hemorheology , transcranial Doppler (TCD) and auditory brainstem evoked response (ABR) features in senile sudden deafness . (bvsalud.org)
  • Clinical Hemorheology. (wikipedia.org)
  • DIC and hemorheology - A clinical study. (nii.ac.jp)
  • 1994. Clinical hemorheology. (sylvester.org)
  • Different drug effects on platelet aggregation, hemorheology, TXB 2 /6-keto-PGF 1α ratio and blood biochemistry were studied. (springer.com)
  • Leblond in an early, textbook of hemorheology, hyperviscosity syndromes were discussed from a pathophysiological point of view [1]: In the case of leukocytes, attachment is followed by migration through the endothelium, while platelets undergo spreading and an aggregation phase, and act as a surface for coagulation and fibrin deposition. (mariobet.mobi)
  • To investigate the impact of different methods of fluid resuscitation on hemorheology during burn shock stage. (unboundmedicine.com)
  • Cerebral and muscle microvascular oxygenation in children with sickle cell disease: Influence of hematology, hemorheology and vasomotion. (univ-antilles.fr)
  • This study aimed to investigate alterations in hemorheology by cold exposure, in vivo and ex vivo, and to determine their relationship to oxidative stress. (nih.gov)
  • Hemorheology, also spelled haemorheology (from the Greek 'αἷμα, haima "blood" and rheology), or blood rheology, is the study of flow properties of blood and its elements of plasma and cells. (wikipedia.org)
  • Hemorheology, also spelled haemorheology (from Greek 'αἷμα, haima 'blood' and rheology, from Greek ῥέω rhéō, 'flow' and -λoγία, -logia 'study of'), or blood rheology, is the study of flow properties of blood and its elements of plasma and cells. (wikipedia.org)
  • With respect to hemorheology, the new book successfully updates developments and advances in the flow properties of human blood cells microrheology. (thecardiffkook.info)
  • The blood flow velocity in the body depends on the emptying capacity of heart, bloodstream resistance, interaction between blood components - hemorheology. (bba-journal.com)
  • Effects of C-peptide on microvascular blood flow and blood hemorheology. (unboundmedicine.com)
  • TY - JOUR T1 - Effects of C-peptide on microvascular blood flow and blood hemorheology. (unboundmedicine.com)
  • Various hemorheology tests were performed on 88 hospitalized ASUC patients, including mean platelet volume (MVP), platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) D-dimer and indicators of thrombelastogram (TEG). (hepatmon.com)
  • The editors of the handbook have each been active in the fields of bio- and hemorheology for many years, and have published extensively. (thecardiffkook.info)
  • If the rate of appearance of publications in the field can be taken as a criterion, hemorheology can be considered as coming of age in the fairly recent past - perhaps forty or so years ago. (thecardiffkook.info)
  • The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. (semcs.net)
  • A welcome feature of the handbook is that it includes a chapter on comparative hemorheology, showing that the rheological properties of red cells vary widely among the animal species, thus shedding light on the process of adaptation to a specific environment or lifestyle, and a chapter on neonatal and fetal blood rheology showing the considerable adaptation processes in play at birth and in infancy and childhood. (thecardiffkook.info)
  • In Clinical Hemorheology and Microcirculation, 2006. (lamedic.ro)
  • Recent research posted to Clinical Hemorheology and Microcirculation found that CBD might ease the inflammation in the pancreas in patients with type 1 diabetes. (nuvelio.com)
  • In a examine printed in Clinical Hemorheology and Microcirculation, it was discovered that CBD can ease inflammation attributable to diabetes in the pancreas of mice. (chateauflorist.com)
  • As per the Clinical Hemorheology and Microcirculation Journal, cannabidiol has been shown to reduce this inflammation, preventing or causing a delay in the onset of Type 1 diabetes. (otito.io)
  • It has a lipolytic, hemorheology (increased supply of oxygen from hemoglobin), cicatrizing and antiedema action. (studiomedicobassani.it)