The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
Electrophoresis, Polyacrylamide Gel
Electrophoresis, Gel, Two-Dimensional
Electrophoresis, Gel, Pulsed-Field
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
Electrophoresis, Agar Gel
Hemoglobin A, Glycosylated
Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
Electrophoresis, Cellulose Acetate
Electrophoresis, Starch Gel
Electrophoresis in which discontinuities in both the voltage and pH gradients are introduced by using buffers of different composition and pH in the different parts of the gel column. The term 'disc' was originally used as an abbreviation for 'discontinuous' referring to the buffers employed, and does not have anything to do with the shape of the separated zones.
A group of abnormal hemoglobins with similar electrophoretic characteristics. They have faster electrophoretic mobility and different amino acid substitutions in either the alpha or beta chains than normal adult hemoglobin. Some of the variants produce hematologic abnormalities, others result in no clinical disorders.
Hemoglobin C Disease
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Anemia, Sickle Cell
A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 22.214.171.124). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
Amino Acid Sequence
Denaturing Gradient Gel Electrophoresis
Chromatography, Ion Exchange
Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
Hemoglobin SC Disease
Chromatography, High Pressure Liquid
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Coagulation Changes in Children with Sickle Cell Anaemia during Painful Crises and Steady State at Federal Medical Centre...
... while steady state values were also significantly higher than that of haemoglobin AA individuals (P = 0.001). Conclusions: This ... This group also had their haemoglobin phenotypes determined by electrophoresis using cellulose acetate strips. ... Cite this paper: Adebola, M. , Olanrewaju, D. , Ogundeyi, M. and Shonde-Adebola, K. (2018) Coagulation Changes in Children with ... The presence of HbS results in a conformational change in the haemoglobin tetramer which causes the de-oxygenated HbS molecules ...
Famous Scientist in Genetic Research: Linus Pauling
Pauling and his co-authors used electrophoreses to demonstrate the presence of a modified form of hemoglobin in those who have ... He published seven papers on the subject during his post-graduate stay in Caltech and graduated summa cum laude in 1925 with a ... This paper was the first to exhibit the role of Mendelian inheritance in determining a proteins physical properties. It ... His experience in working with hemoglobin as well as his theory of specificity in biological molecules led him to believe that ...
Magellan Rx Management Cool News Features | Magellan Rx Management » Print
Using electrophoresis, Dr Pauling and colleagues demonstrated that sickle cell anemia was caused by an abnormal form of ... In 1949, Dr Linus Pauling coined the term molecular disease when describing sickle cell anemia in a landmark paper published in ... hemoglobin. November 20, 2019. mPulse Mobile celebrates innovation and health outcomes with second annual activate awards. ...
Hemoglobin E | Semantic Scholar
An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is ... Papers overview. Semantic Scholar uses AI to extract papers important to this topic. ... Hemoglobin E:PrThr:Pt:Bld:Ord:Electrophoresis. Process of secretion. Expand. Narrower. (. 1. ). hemoglobin E Saskatoon ... Hemoglobin E. Known as: Hemoglobin E [Chemical/Ingredient], e hemoglobin, haemoglobin e ...
Filed under: Documentary History Websites, Hemoglobin & Sickle Cell Anemia , Tagged: Arne Tiselius, electrophoresis, genetics, ... published the first four papers of what would ultimately become a fifteen-paper series. This body of scholarship was the ... Filed under: Documentary History Websites, Hemoglobin & Sickle Cell Anemia , Tagged: hemoglobin, immunology, Karl Landsteiner, ... susceptibility of hemoglobin and hemoglobin derivatives?" So I did. And they gave me fifty thousand dollars. This shows that ...
Genetics Worksheet Part 2 Answers
Sand Paper Invented Invented by I. Structures of the Cell. If you want to download you have to send your own contributions. ... Electrophoresis buffer, 50x. Step 7 Using the results of Steps 5 and 6, answer the problem. Mendel and basic genetics packet ws ... Sickle Cell Anemia Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin ... Do this on a separate sheet of paper (staple it to this review). The mean on this test is 52 and the standard deviation is 5. ...
Clinical Research Summary - Lucky Iron Fish
Hemoglobin electrophoresis was used to detect structural hemoglobin variants. RESULTS. Anemia prevalence was 44% with the use ... This paper presents a situation analysis of the burden of anemia in Cambodia, including a discussion of the country-specific ... The mean hemoglobin for all ages at baseline was 11.3 g/dL (SD 0.9). At 12 months, the mean was 11.9 g/dL (SD 0.8), with a mean ... Hemoglobin concentrations were greater by 11.8 g/L (95% CI: 9.1, 14.6; P. CONCLUSION. The iron ingot shaped as a lucky fish is ...
Severe Malaria Not Responsive to Artemisinin Derivatives in Man Returning from Angola to Vietnam - Volume 20, Number 7-July...
At day 4, the hemoglobin level had decreased to 9.3 g/dL and the patient was given a blood transfusion. After 5 consecutive ... Further genotyping by using nested PCR (merozoite surface proteins 1 and 2 repeat markers) and capillary electrophoresis (10) ... of several filter paper blood spots obtained during the 23 days of hospitalization confirmed that the patient had a polyclonal ... Blood tests showed the following results: leukocyte count 13.3 × 109/cells/L, hemoglobin 153 g/L, platelet count 20.9 × 109/L, ...
Medical Lighting Bulbs : Medical Device Depot, Inc.
Clinton Fun Series Scale Tables
Laparoscopic Systems Needle Holders
Pharmacy Freestanding Refrigerator Freezer Combos
Cleaning Disinfecting Sterile Processing
Welch Allyn Spirometers
Criticare nGenuity 8100EP1 Patient Monitor w/ CO2 & Printer
OB GYN Forceps
3DL Rectangle Top, Studio Uptown Finish, Gray U- Base, Low Base 1.75"
Skin Surface Microscopes
Sickle cell a2
- In 1949, Dr Linus Pauling coined the term molecular disease when describing sickle cell anemia in a landmark paper published in Science. (magellanrx.com)
- Using electrophoresis, Dr Pauling and colleagues demonstrated that sickle cell anemia was caused by an abnormal form of hemoglobin. (magellanrx.com)
- Hemoglobin electrophoresis was used to detect structural hemoglobin variants. (luckyironfish.com)
- An investigation of hemoglobin, Pauling quickly decided, would require more than one year to obtain results. (wordpress.com)
- Although Pauling had originally intended for the grant money to go specifically toward his work on hemoglobin, as he corresponded with his funders he expressed an openness to studying other "interesting biochemical problems," and indeed this quickly became the case. (wordpress.com)
- An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. (semanticscholar.org)
- Do literature search then perform electrophoresis and kinetics experiments independently or as a team in a safe manner and report and results using scientific writing. (uaeu.ac.ae)
- Haemoglobin, serum iron and C-reactive protein concentrations were measured at baseline, 3 and 6 months. (luckyironfish.com)
- This proficiency in theoretical mathematics on the mechanics of atoms and molecules yielded fifty papers during his five year tenure as a professor at Cal-tech. (thebrightesthub.com)
- One of Pauling's first major forays into the world of biology came about through his study of hemoglobin, the molecule responsible for transporting oxygen in the blood. (wordpress.com)
- Specifically, in 1934, he launched a study hemoglobin partly as a means to begin a larger inquiry into the structure of proteins. (wordpress.com)
- Blood was analyzed for hemoglobin, serum ferritin, and serum transferrin receptor. (luckyironfish.com)
- A simplified screening strategy for thalassaemia and haemoglobin E in rural communities in south-east Asia. (semanticscholar.org)
- We sought to determine whether there was a difference in hemoglobin concentrations in rural Cambodian anemic women (aged 18-49 y) who cooked with the iron ingot or consumed a daily iron supplement compared with a control after 1 y. (luckyironfish.com)
- The journal publishes the most significant new research papers or any other original contribution in the form of reviews and reports on new concepts in all areas pertaining to its scope and research being done in the world, thus ensuring its scientific priority and significance. (stmjournals.in)