The circulation of the BLOOD through the vessels of the KIDNEY.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.
The vessels carrying blood away from the heart.
The flow of BLOOD through or around an organ or region of the body.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
The arterial blood vessels supplying the CEREBRUM.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.
The main artery of the thigh, a continuation of the external iliac artery.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
The circulation of the BLOOD through the LUNGS.
The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
The circulation of blood through the CORONARY VESSELS of the HEART.
Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.
Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
The veins and arteries of the HEART.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
Artery originating from the internal carotid artery and distributing to the eye, orbit and adjacent facial structures.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Specialized arterial vessels in the umbilical cord. They carry waste and deoxygenated blood from the FETUS to the mother via the PLACENTA. In humans, there are usually two umbilical arteries but sometimes one.
Elements of limited time intervals, contributing to particular results or situations.
The arterial trunk that arises from the abdominal aorta and after a short course divides into the left gastric, common hepatic and splenic arteries.
Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).
A large vessel supplying the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.
Drugs used to cause dilation of the blood vessels.
Left bronchial arteries arise from the thoracic aorta, the right from the first aortic intercostal or the upper left bronchial artery; they supply the bronchi and the lower trachea.
Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
The circulation of BLOOD through the LIVER.
Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles, mammary gland and the axillary aspect of the chest wall.
Radiography of blood vessels after injection of a contrast medium.
Branch of the common carotid artery which supplies the exterior of the head, the face, and the greater part of the neck.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Arteries arising from the external carotid or the maxillary artery and distributing to the temporal region.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The circulation of BLOOD, of both the mother and the FETUS, through the PLACENTA.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
The larger of the two terminal branches of the brachial artery, beginning about one centimeter distal to the bend of the elbow. Like the RADIAL ARTERY, its branches may be divided into three groups corresponding to their locations in the forearm, wrist, and hand.
A branch arising from the internal iliac artery in females, that supplies blood to the uterus.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
The nonstriated involuntary muscle tissue of blood vessels.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Radiography of the vascular system of the brain after injection of a contrast medium.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
Drugs used to cause constriction of the blood vessels.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Recycling through liver by excretion in bile, reabsorption from intestines (INTESTINAL REABSORPTION) into portal circulation, passage back into liver, and re-excretion in bile.
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum.
The vessels carrying blood away from the capillary beds.
Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
Sudden ISCHEMIA in the RETINA due to blocked blood flow through the CENTRAL RETINAL ARTERY or its branches leading to sudden complete or partial loss of vision, respectively, in the eye.
The condition of an anatomical structure's being constricted beyond normal dimensions.
A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The relationship between the dose of an administered drug and the response of the organism to the drug.
The hollow, muscular organ that maintains the circulation of the blood.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.
Application of a ligature to tie a vessel or strangulate a part.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
The main trunk of the systemic arteries.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
Arteries which supply the dura mater.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Measurement of oxygen and carbon dioxide in the blood.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Determination of the shortest time interval between the injection of a substance in the vein and its arrival at some distant site in sufficient concentration to produce a recognizable end result. It represents approximately the inverse of the average velocity of blood flow between two points.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
Narrowing or constriction of a coronary artery.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
The degree to which BLOOD VESSELS are not blocked or obstructed.
Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Relatively complete absence of oxygen in one or more tissues.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Ultrasonography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.
Delivery of drugs into an artery.
The deformation and flow behavior of BLOOD and its elements i.e., PLASMA; ERYTHROCYTES; WHITE BLOOD CELLS; and BLOOD PLATELETS.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
A polygonal anastomosis at the base of the brain formed by the internal carotid (CAROTID ARTERY, INTERNAL), proximal parts of the anterior, middle, and posterior cerebral arteries (ANTERIOR CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY; POSTERIOR CEREBRAL ARTERY), the anterior communicating artery and the posterior communicating arteries.
The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Distensibility measure of a chamber such as the lungs (LUNG COMPLIANCE) or bladder. Compliance is expressed as a change in volume per unit change in pressure.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.
A branch of the external carotid artery which distributes to the deep structures of the face (internal maxillary) and to the side of the face and nose (external maxillary).
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Placement of a balloon-tipped catheter into the pulmonary artery through the antecubital, subclavian, and sometimes the femoral vein. It is used to measure pulmonary artery pressure and pulmonary artery wedge pressure which reflects left atrial pressure and left ventricular end-diastolic pressure. The catheter is threaded into the right atrium, the balloon is inflated and the catheter follows the blood flow through the tricuspid valve into the right ventricle and out into the pulmonary artery.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
"Impact of aortic stiffness on survival in end-stage renal disease". Circulation. 99 (18): 2434-9. doi:10.1161/01.cir.99.18.2434 ... This function depends on the elasticity of the arteries and stiffened arteries require a greater amount of force to permit them ... Nicolaas Westerhof; Nikolaos Stergiopulos; Mark I.M. Noble (2 September 2010). Snapshots of Hemodynamics: An Aid for Clinical ... stiffened arteries compromise the Windkessel effect of the arteries. The Windkessel effect buffers the pulsatile ejection of ...
renal circulation. 25%. high. over-perfused. Maintains glomerular filtration rate skeletal muscular circulation. 17%[3]. ... Blood flow through the left coronary artery is at a maximum during diastole (in contrast to the rest of systemic circulation, ... Hemodynamics[edit]. Under most circumstances, the body attempts to maintain a steady mean arterial pressure. ... Name of circulation. % of cardiac output. Autoregulation. Perfusion. Comments pulmonary circulation. 100% (deoxygenated). ...
Renal surgery and coronary artery bypass grafting can produce renal ischemia and reperfusion injury. This could lead to an ... Acute kidney ischemia may result from taking ACEIs due to the alteration of intrarenal hemodynamics. Acute pulmonary edema is ... or the amount of the drug that reaches the blood circulation, is reduced if taken orally. Fenoldopam is used as a vasodilator ... Renovascular hypertension or renal artery stenosis is characterized as an increase in blood pressure through the arteries to ...
... on Myocardial Energy Metabolism and Hemodynamics in Patients with Severe Congestive Heart Failure Due to Coronary Artery ... Japanese Circulation Journal. 63 (8): 605-9. doi:10.1253/jcj.63.605. PMID 10478810. Klein N.A.; Siskind S.J.; Frishman W.H.; ... "Sustained Beneficial Effects of Oral Amrinone on Cardiac and Renal Function in Patients With Severe Congestive Heart Failure". ... Circulation. 70 (6): 1038-1047. doi:10.1161/01.cir.70.6.1038. PMID 6388899. Carabello B.A. (1980). "Effects of Amrinone ...
In 1981, he invented an interface process which allows for the first time the visualization of supra-aortic arteries by B-Mode ... In 1980 he described the Fistula Flow Ratio (French 'RDF') to assess the flow of arteriovenous fistulas, especially in renal ... Franceschi's major work was to match the principles of fluid mechanics with arterial and venous hemodynamics. After studying ... where he offers a new approach to the physiology of deep and superficial venous circulation, introducing new concepts such as ...
The other causes are usually divided into renal and extrarenal causes. Renal causes include overuse of diuretics, or trauma or ... Circulation. 56 (4): 605-612. doi:10.1161/01.cir.56.4.605. PMID 902387. Van, P.Y.; Cho, S.D.; Underwood, S.J.; Hamilton, G.J; ... Compared With Pulmonary Artery Catheter Alone, to Guide Shock Resuscitation in Critically Ill Surgical Patients". Shock. 35 (3 ... Hemodynamics, and Patient Outcomes". American Journal of Cardiology. 93 (10): 1254-1259. doi:10.1016/j.amjcard.2004.01.070. ...
This flipped vortex circulation could lead to further complications in the patient who had mitral valve replacement surgery as ... The catheter may be inserted through the femoral artery in the thigh, or through a small incision in the chest. Once the ... renal shutdown, cardiac tamponade, stroke, or reaction to anesthesia. The risk of death is about 1%. Risks depend on a ... offering desirable haemodynamics. The two leaflets of a bileaflet disc valve open during diastole and close during systole. ...
Hemodynamics (blood circulation)Edit. Blood velocity can be measured in various blood vessels, such as middle cerebral artery ... and fast aid for decision-making in patients with renal symptoms and for guidance in renal intervention.[19] Renal ultrasound ( ... Using B-mode imaging, assessment of renal anatomy is easily performed, and US is often used as image guidance for renal ... Main article: Renal ultrasonography. In nephrology, ultrasonography of the kidneys is essential in the diagnosis and management ...
Their role is to conduct extracorporeal circulation as well as ensure the management of physiologic functions by monitoring the ... They are often referred to as hemodinamistas (hemodynamics specialists). "Yuri Ganushchak". European Association for ... renal cell carcinoma/obstructive vena cava veno-venous bypass (e.g. during liver transplants) cardiac/lung transplants implants ... coronary artery bypass, aortic valve replacements, mitral valve repair/mitral valve replacement tricuspid valve repair aortic ...
renal artery &. afferent arterioles. vasoconstriction (weaker). VDCCs → Ca2+ influx. efferent arteriole. vasoconstriction ( ... "Circulation Research. 93 (11): 1015-1017. doi:10.1161/01.RES.0000105920.33926.60. ISSN 0009-7330. PMID 14645130.. ... "Function of the Juxtaglomerular Apparatus: Control of Glomerular Hemodynamics and Renin Secretion" Jürgen B. Schnermann and ... RenalEdit. Angiotensin II has a direct effect on the proximal tubules to increase Na+ reabsorption. It has a complex and ...
Contrast material-induced renal failure in patients with diabetes mellitus, renal insufficiency, or both. N Engl J Med 1989;320 ... Circulation 1989; 79:810. Koyano, K; Sakaguchi, S. Selective stripping operation based on doppler findings for primary varicose ... Air plethysmography and the effect of elastic compression on the venous haemodynamics of the leg. J Vasc Surg 1987;5:148-159. ... It is impossible to visualize arteries by translumination, because they do not provide a reflection due to their accelerated ...
The muscular pulmonary arteries become fibrotic and hypertrophy while the smaller arteries lose smooth muscle cells and their ... Krowka, MJ; Plevak, DJ; Findlay, JY; Rosen, CB; Wiesner, RH; Krom, RA (July 2000). "Pulmonary hemodynamics and perioperative ... Budhiraja, R; Hassoun, PM (February 2003). "Portopulmonary hypertension: a tale of two circulations". Chest. 123 (2): 562-76. ... role of splanchnic and renal passage and liver function". Hepatology. 21 (3): 735-9. PMID 7875671. Stewart, DJ; Levy, RD; ...
When renal blood flow is reduced, juxtaglomerular cells in the kidneys convert the precursor prorenin (already present in the ... renin is predominantly picked up from the circulation but may be secreted locally in some tissues; its precursor prorenin is ... Aldosterone causes the renal tubules to increase the reabsorption of sodium and water into the blood, while at the same time ... Angiotensin II stimulates the hypertrophy of renal tubule cells, leading to further sodium reabsorption. ...
Renal artery stenosis (RAS) may be associated with a localized abdominal bruit to the left or right of the midline (unilateral ... Part I: definition and etiology". Circulation. 101 (3): 329-35. doi:10.1161/01.CIR.101.3.329. PMID 10645931. Whelton PK, Carey ... "Prediction of future hypertension by casual blood pressure or invasive hemodynamics? A 30-year follow-up study". Blood Pressure ... renal artery stenosis (from atherosclerosis or fibromuscular dysplasia), hyperparathyroidism, and pheochromocytoma. Other ...
The arteries that leave the aortic arch are positioned symmetrically. There is no costocervical artery. There is no direct ... Renal blood supply during dives is also affected by selective arterial vasoconstriction, and can drop below 10% of surface ... High hematocrit blood is stored in the large spleen of deep-diving seals, and may be released into the circulation during a ... Ponganis, Paul (2015). "6. Adaptations in cardiovascular anatomy and hemodynamics". Diving Physiology of Marine Mammals and ...
Fronek, A; Ganz, V (1959). "[Local thermodilution method of measuring minute volume and circulation rate in the peripheral ... Except during hypothermia and in severe sepsis, low mixed venous oxygen saturations are indication of inadequate hemodynamics. ... Acute renal failure aka Acute Kidney Injury. *Burns. *Management of postoperative open heart surgical patients ... Pulmonary artery catheterization (PAC), or right heart catheterization, is the insertion of a catheter into a pulmonary artery ...
Hemodynamics affect the development of AAA, which has a predilection for the infrarenal aorta. The histological structure and ... Bruits can be present in case of renal or visceral arterial stenosis. The signs and symptoms of a ruptured AAA may include ... "Study establishes major new treatment target in diseased arteries". U.S. News & World Report. May 10, 2009. Archived from the ... The case for early resection". Circulation. 56 (3 Suppl): II161-4. PMID 884821. Nicholls SC, Gardner JB, Meissner MH, Johansen ...
... renal, upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the ... "Saphenous vein graft failure after coronary artery bypass surgery: insights from PREVENT IV". Circulation. 130 (17): 1445-51. ... the vein with external support prior to grafting has shown to reduce intimal hyperplasia formation and improve the hemodynamics ... "Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from ...
Mean blood pressure drops over the whole circulation, although most of the fall occurs along the small arteries and arterioles. ... The word hemodynamics (/ˌhiːmədaɪˈnæmɪks, -moʊ-/[27]) uses combining forms of hemo- and dynamics, thus "the dynamics of blood ... The smaller arteries and arterioles have higher resistance, and confer the main blood pressure drop across major arteries to ... In the innominate artery, the average reading is 110/70 mmHg, the right subclavian artery averages 120/80 and the abdominal ...
... axillary artery aneurysm, brachiocephalic artery aneurysm, aneurysm of iliac and femoral arteries, and renal artery aneurysm. ... April 2005). "Arterial hemodynamics in patients after Kawasaki disease". Circulation. 111 (16): 2119-25. doi:10.1161/01.CIR. ... Circulation. 135 (17): e927-e999. doi:10.1161/CIR.0000000000000484. PMID 28356445."Correction". Circulation. 140 (5): e181-e184 ... Coronary artery aneurysms occur as a sequela of the vasculitis in 20-25% of untreated children. It is first detected at a mean ...
Circulation. February 2010, 121 (7): e46-e215. PMID 20019324. doi:10.1161/CIRCULATIONAHA.109.192667.. 引文格式1維護:顯式使用等標籤 (link) ... Prediction of future hypertension by casual blood pressure or invasive hemodynamics? A 30-year follow-up study. Blood Press. ... Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis ... 血管疾病[*], artery disease[*], 醫學徵象, hypertension[*]. 肇因. 生活形態或
Renal vein thrombosisEdit. Main article: Renal vein thrombosis. Renal vein thrombosis is the obstruction of the renal vein by a ... When a blood vessel (a vein or an artery) is injured, the body uses platelets (thrombocytes) and fibrin to form a blood clot to ... The template below (Hemodynamics) is being considered for deletion. See templates for discussion to help reach a consensus. › ... In people with a "shunt" (a connection between the pulmonary and systemic circulation), either in the heart or in the lung, a ...
Circulation. 107 (3): 499-511. doi:೧೦.೧೧೬೧/೦೧.CIR.೦೦೦೦೦೫೨೯೩೯.೫೯೦೯೩.೪೫ Check ,doi=. value (help). PMID ೧೨೫೫೧೮೭೮ Check ,pmid=. ... of a branch of the left coronary artery (LCA, right coronary artery = RCA). ... "Renal function as a risk indicator for cardiovascular events in 3216 patients with manifest arterial disease". Atherosclerosis ... Circulation. 97 (18): 1837-47. PMID ೯೬೦೩೫೩೯ Check ,pmid=. value (help).. CS1 maint: multiple names: authors list (link). ...
... and may signify renal artery stenosis.[19] Prevention of recurrence is based on managing hypertension, coronary artery disease ... It is due to either failure of the left ventricle of the heart to remove blood adequately from the pulmonary circulation ( ... The template below (Hemodynamics) is being considered for deletion. See templates for discussion to help reach a consensus. › ... Recurrent pulmonary oedema in hypertension due to bilateral renal artery stenosis: treatment by angioplasty or surgical ...
"Circulation. 132 (18 Suppl 2): S526-42. doi:10.1161/cir.0000000000000266. PMC 6191296. PMID 26473000.. ... Acute renal failure. Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction ... Intermittent or continuous renal replacement therapy may be used if indicated. However, sodium bicarbonate is not recommended ... and renal replacement therapy.[6] Achieving partial or full enteral feeding (delivery of nutrients through a feeding tube) is ...
The left side pumps blood into the systemic circulation, whilst the right side pumps blood into the pulmonary circulation. ... X-ray images are called angiograms.[44] Heart failure may be the result of coronary artery disease, and its prognosis depends ... Abnormal hemodynamics at rest. +++. ++. + = some importance; ++ = intermediate importance; +++ = great importance.. ... "Circulation. 119 (14): 1977-2016. doi:10.1161/CIRCULATIONAHA.109.192064. PMID 19324967.. *^ a b "high-output heart failure" at ...
The method requires catheterization of both the renal artery and the renal vein, a single injection of dye into the renal ... A dye-dilution method of measuring renal hemodynamics in man has been described. ... Renal Circulation in Man Studied by Means of a Dye-Dilution Method. FRANÇOIS C. REUBI, NICOLAS GOSSWEILER, RENÉ GUÜRTLER ... Renal Circulation in Man Studied by Means of a Dye-Dilution Method ...
A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal ... hemodynamics in the rat. Kon, V., Harris, R.C., Ichikawa, I. J. Clin. Invest. (1990) [Pubmed] ... Recovery of renal function. Luft, F.C., Bloch, R., Szwed, J.J., Grim, C.M., Grim, C.E. JAMA (1978) [Pubmed] ... Dietary protein restriction in established renal injury in the rat. Selective role of glomerular capillary pressure in ...
Goldblatt mouse model was developed using polyurethane tubing to initiate renal artery stenosis,... ... Adrenal-renal portal circulation contributes to decrease in renal blood flow after renal artery stenosis in rats. Journal of ... filtration rate after renal revascularization correlate with microvascular hemodynamics and inflammation in Swine renal artery ... 2. Right renal artery stenosis. *Place two nylon sutures under the right renal artery, make loose knots, and then place the ...
Adenosine-dependent regulation of renal function in healthy and diseased kidney is mediated by activation of the four types of ... Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat. J Clin Invest 85:1728-1733PubMed ... Kon V, Harris RC, Ichikawa I (1990) A regulatory role for large vessels in organ circulation. ... Thurau K (1964) Renal hemodynamics. Am J Med 36:850-860CrossRefGoogle Scholar ...
The acute effects of nitroprusside infusion and intravenous hydralazine on renal hemodynamics and function were evaluated in ... Nitroprusside had a more profound effect on pulmonary artery pressure, while hydralazine produced a greater elevation in ... Total renal resistance decreased and renal blood flow (RBF) significantly increased with both drugs, while the distribution of ... Renal effects of nitroprusside and hydralazine in patients with congestive heart failure.. J J Cogan, M H Humphreys, C J ...
1998) Effects of dopamine on renal haemodynamics tubular function and sodium excretion in normal humans. Dan Med Bull 45:282- ... In the coronary circulation, anatomic abnormalities do not coincide with functional significance (21,22). Assessment of ... renal flow reserve (RFR), and/or renal fractional flow reserve (rFFR) in patients with and without renal artery stenosis. ... renal function, and blood pressure in hypertensive and renal insufficient patients with renal artery stenosis. Cathet ...
Renal haemodynamics and severity of carotid atherosclerosis in hypertensive patients with and without impaired renal function. ... and increased intima/media ratio of renal small arteries regardless of renal function, and other authors obtained similar ... Increased arterial stiffness might therefore predispose the renal circulation to a greater hemodynamic burden (pulse more than ... Renal resistive index-a valid tool to assess renal endothelial function in humans? Nephrol Dial Transplant 2010;25:1869-74. ...
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Portal Vein / Ascites / Renal Artery / Renal Circulation / ... Full text: Available Index: IMSEAR (South-East Asia) Main subject: Portal Vein / Ascites / Renal Artery / Renal Circulation / ... Assessment of renal and hepatic hemodynamics in cirrhosis of liver. Assessment of renal and hepatic hemodynamics in cirrhosis ... of the hepatic artery was measured by color Doppler on its main branch and renal artery RI was measured on the main renal, ...
Renal hemodynamics in essential and renovascular hypertension. Influence of captopril. Am J Med. 1984 May 31; 76(5B):22-8. ...
Cardiac output (Q) and pulmonary artery pressure (PAP) were measured. JVA and ionJVA were calculated from changes in plasma ... Pulmonary circulation transvascular fluid fluxes (JVA) are attributed to changes in hydrostatic forces and erythrocyte volume ( ... Cardiac output (Q) and pulmonary artery pressure (PAP) were measured. JVA and ionJVA were calculated from changes in plasma ... Pulmonary circulation transvascular fluid fluxes (JVA) are attributed to changes in hydrostatic forces and erythrocyte volume ( ...
Sigmon DH, Beierwaltes WH: Degree of renal artery stenosis alters nitric oxide regulation of renal hemodynamics. J Am Soc ... A practical proliferative model in porcine coronary arteries. Circulation82 : 2190-2200,1990. ... Renal Arteries. The most striking result implantation of the copper stent produced in the renal artery was a fibroproliferative ... Experimental induction of renal artery stenosis (traditionally achieved by either surgical ligation of the renal artery or ...
... that these vessels are controlled by the hemodynamics of large arteries rather than small vessels in the peripheral circulation ... the afferent arteriole branch from the renal artery is a short vessel exposed to high pressures and, therefore, must maintain a ... renal microvascular damage, and an increased risk of renal dysfunction [23]. The combination of endothelial dysfunction and ... R. Retnakaran, C. A. Cull, K. I. Thorne, A. I. Adler, R. R. Holman, and UKPDS Study Group, "Risk factors for renal dysfunction ...
keywords = "Afferent arteriole, Hyperpolarization, KCNQ, Renal hemodynamics, Renal vascular resistance",. author = "M. ... Renal blood flow (RBF) was measured using an ultrasonic flow probe. The isometric tension of rat interlobar arteries was ... Renal blood flow (RBF) was measured using an ultrasonic flow probe. The isometric tension of rat interlobar arteries was ... Renal blood flow (RBF) was measured using an ultrasonic flow probe. The isometric tension of rat interlobar arteries was ...
... filtration rate after renal revascularization correlate with microvascular hemodynamics and infilammation in swine renal artery ... In: Circulation: Cardiovascular Interventions, Vol. 5, No. 5, 01.10.2012, p. 720-728.. Research output: Contribution to journal ... filtration rate after renal revascularization correlate with microvascular hemodynamics and infilammation in swine renal artery ... filtration rate after renal revascularization correlate with microvascular hemodynamics and infilammation in swine renal artery ...
Outer medullary descending vasa recta (OMDVR) are microscopic vessels providing blood flow to the renal medulla. Data on the ... The renal medulla plays an important role in the control of water and salt balance by the kidney. ... Our model may be suitable for investigating disturbances of renal medullary circulation in human subjects. Acta Physiologica © ... 1913759 - Effect of glyceryl trinitrate on distensibility of peripheral muscular arteries in huma.... 24901409 - Update on the ...
... after endured coronary artery bypass grafting (CABG) performed in conditions of extracorporeal circulation (EC) and on the ... of alterations in cardiopulmonary haemodynamics and renal functional activity in patients with endured coronary artery bypass ... methods to assess alterations in cardiopulmonary haemodynamics and renal functional activity in patients with coronary artery ... of alterations in cardiopulmonary haemodynamics and renal functional activity in patients with endured coronary artery bypass ...
Middle Cerebral Artery , Norepinephrine , Plasma , Portal Pressure , Renal Circulation , Renin , Sympathetic Nervous System , ... Arterial Pressure , Arteries , Ascites , Cardiac Output, High , Fibrosis , Hemodynamics , Humans , Hypertension, Portal , ... METHODS: The resistive index in the middle cerebral artery and in a renal interlobar artery were measured by Doppler ... Studies assessing regional hemodynamics in patients of cirrhosis with ascites have shown vasoconstriction in the renal ...
... specifics of some circulations (coronary, cerebral, pulmonary, renal, hepatic, skeletal muscle and cutaneous). ... Functional morphology of the vessels, general hemodynamics (velocity of blood flow, flow rate, types of blood flow, blood ... pressure, resistance of the vessels), functions of arteries, functions of capillaries, functions of veins, regulation of the ...
However, these methods disturb hemodynamics and have an adverse impact on a patients circulatory and renal functions. In our ... This technique maximizes the control of hepatic vein bleeding, while having minimal effect on systemic circulation and blood ... rather than the individual ligation of the hepatic artery, portal vein and biliary tract. The en bloc interruption of Glissons ... The serosal membrane covering the IVC was dissected above the renal veins and below the lower liver margin using a tangential ...
The Pharmacological Effect of Contrast Media on Renal Circulation Measured by Means of Angiodensitometry ... For the measure- ment of rapid phenomena, such as the blood flow in the main arteries, high image-frame rates are required, and ... Determination of Portal and Arterial Liver Hemodynamics by Angiodensitometry H. D. Piroth ... Physical and Technical Basics for the Radiological Analysis of Circulation. * Front Matter Pages 49-49 ...
0.70 is seen in renal artery stenosis, hypotension, renal vein thrombosis, and arterial stiffness (2). In contrast, renal ... Under normal conditions, blood flow in the renal arterial circulation is antegrade and maintained during diastole. When renal ... Invasive pressure measurement with a pulmonary artery catheter. In the first 10 HFrEF patients, central hemodynamics with a ... Renal vascular ultrasound has been used to assess the degree of severity of renal artery stenosis or to assess vascular and ...
Baylis C, Qiu C. Importance of nitric oxide in the control of renal hemodynamics. Kidney Int. 1996;49:1727-1731. ... No subjects were taking medication known to affect the retinal, renal, or systemic circulation. Control subjects were receiving ... brachial artery, r=0.617, P=0.0003; retinal artery, r=0.599, P=0.0005; interlobar artery, r=0.636, P=0.0002). In addition, ... Endothelium-derived NO has also been shown to regulate renal and ocular blood flow.5 6 7 In isolated ophthalmic arteries, NO is ...
... a first renal artery, first and second renal arteries, or any suitable combination of the above listed branch vessels. ... If these branch vessels are blocked by the prosthesis, the original blood circulation is impeded, and the patient can suffer. ... This mimics a typical physiological anastomosis, and improves the hemodynamics of flow into the prosthetic branch 44. The ... can be designed to extend above the renal arteries and to have prosthetic branches that extend into the renal arteries. ...
These investigators also demonstrate that femoral flow wave abnormalities are related to adverse renal artery hemodynamics, ... first by decreasing the normal diastolic flow reversal thought to be needed for appropriate circulation to the truncal organs, ... Renal Function and Albuminuria. Table 2 summarizes the difference in renal function measures between the patients with T2DM and ... Exercise Central Hemodynamics and Albuminuria. It is worth noting that central hemodynamics (Pexcess) measured during light- to ...
Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries.Circulation. ... Publications] I.Hamanaka et al.: Effects of cardiotrophin-1 on hemodynamics and endocrine function of the heart.Am.Physiol. ... BNP Tg showed less significant renal damage, when the kidney was severely-injuried, suggesting the protective role of ... Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries.Circulation. ...
Impact of endovascular treatment of atherosclerotic renal artery stenosis on endothelial function and arterial blood pressure. ... "The seagull cry": a sign of emergency after renal transplantation? Circulation, 121(5):e25-e26. ... Impact of obesity on venous hemodynamics of the lower limbs. Journal of Vascular Surgery, 52(3):664-668. ... Predictive value of duplex ultrasound for restenosis after renal artery stenting. Clinical Hemorheology and Microcirculation, ...
Effect of insulin on renal sodium handling and renal haemodynamics in insulin-dependent (type 1) diabetes mellitus patients. ... Hyperglycemia and angiotensin-mediated control of the renal circulation in healthy humans. Hypertension 33 : 559 -564, 1999. ... Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in ... Higashi Y, Oshima T, Ozono R, Watanabe M, Matsuura H, Kajiyama G: Effects of L-arginine infusion on renal hemodynamics in ...
Their use in congestive heart failure and renal disease is under investigation. ... Candesartan has been shown to have vasodilator effects within the renal circulation by decreasing renal vascular resistance.32 ... acute renal failure or death.5-8,13 These drugs should not be used in patients with bilateral renal artery stenosis. ... 1 Blockade of the renin-angiotensin-aldosterone system at the AT1 receptor site causes changes in renal hemodynamics and sodium ...
Mechanisms of Tissue Injury in Renal Artery Stenosis: Ischemia and Beyond. Lerman, L. O., Textor, S. C. & Grande, J. P., Nov 1 ... Lavi, S., McConnell, J. P., Rihal, C. S., Prasad, A., Mathew, V., Lerman, L. O. & Lerman, A., May 1 2007, In : Circulation. 115 ... The use of magnetic resonance to evaluate tissue oxygenation in renal artery stenosis. Textor, S. C., Glockner, J. F., Lerman, ... Positron-emission tomography imaging of the angiotensin II subtype 1 receptor in swine renal artery stenosis. Xia, J., Seckin, ...
18 to 24 hours after the renal artery was clamped (clamping time, 60 to 90 min). Before the artery was clamped, renal blood ... 18 to 24 hours after the renal artery was clamped (clamping time, 60 to 90 min). Before the artery was clamped, renal blood ... 18 to 24 hours after the renal artery was clamped (clamping time, 60 to 90 min). Before the artery was clamped, renal blood ... 18 to 24 hours after the renal artery was clamped (clamping time, 60 to 90 min). Before the artery was clamped, renal blood ...
  • Renal artery stenosis is a common condition in patients with coronary or peripheral vascular disease where the renin angiotensin aldosterone system (RAAS) is overactivated. (
  • The molecular and cellular mechanism of renin control in renal artery stenosis is not fully understood and warrants further investigation. (
  • To induce renal artery stenosis in mice, a modified 2 kidney 1 clip (2K1C) Goldblatt mouse model was developed. (
  • After renal artery stenosis, we determined renin expression and kidney injury. (
  • Renal artery stenosis (RAStenosis) is an intractable problem affecting about 6% of people over 65 and in up to 40% of people with coronary or peripheral vascular disease 1 , 2 . (
  • However, there are no technical reports available, which describe a step by step procedure to generate renal artery stenosis in animal models. (
  • Conventional U-shaped silver clips, polyurethane tubes and other clips have been used to constrict the renal artery to induce renal artery stenosis. (
  • Next to differences in clinical characteristics, the selection of renal arteries suitable for intervention is currently on the basis of anatomic grading of the stenosis by angiography rather than functional assessment under hyperemia. (
  • Renal artery stenosis is associated with increased risk for kidney failure and is an independent predictor of mortality (1,2) . (
  • Balloon angioplasty with or without stent placement has been used as a treatment modality for renovascular hypertension and preservation of kidney function in patients with renal artery stenosis. (
  • This was confirmed in a recent meta-analysis of randomized clinical trials comparing revascularization and medical therapy for renal artery stenosis demonstrating that angioplasty with or without stenting was not superior to medical therapy across a wide range of clinical endpoints (5) . (
  • Intrarenal hemodynamics and excretory function distal to renal artery stenosis are difficult to quantify noninvasively. (
  • In this study, a swine model of chronic unilateral renal artery stenosis, achieved by implantation of an intravascular device that leads to a gradual and progressive luminal area narrowing, was developed and evaluated. (
  • Renal artery stenosis has long been known to be the major cause of renovascular hypertension in humans, and may result in target organ damage, ischemic nephropathy, and end-stage renal disease ( 1 ). (
  • Furthermore, despite intense investigation both in humans and in various animal models of renal artery stenosis, the mechanisms responsible for the progressive renal functional and structural alterations are still unclear, partly due to the lack of reliable, noninvasive techniques capable of quantifying renal regional hemodynamics and function in the intact kidney distal to a stenosis in the renal artery. (
  • Experimental induction of renal artery stenosis (traditionally achieved by either surgical ligation of the renal artery or devices surgically placed around it) in animal models, such as the dog ( 3 , 4 ) and the rat ( 5 , 6 ), has indeed enabled extensive studies and greatly contributed to the understanding of mechanisms underlying consequences of renal hypoperfusion. (
  • Nevertheless, although the pig may represent a favorable model to study renal pathophysiology, with its renal anatomy and physiology comparable to those of humans ( 7 ), a well-established model of experimental swine renal artery stenosis has not been described, nor has it been resolved whether the pig would develop renovascular hypertension consequent to chronic renal artery stenosis. (
  • However, the feasibility and effectiveness of a percutaneous approach in producing a progressive stenosis in the renal artery have not been evaluated. (
  • Background: The selection of patients with renal artery stenosis (RAS) likely to improve glomerular fltration rate (GFR) after percutaneous transluminal renal angioplasty is difficult. (
  • Renal vascular ultrasound has been used to assess the degree of severity of renal artery stenosis or to assess vascular and endothelial dysfunction. (
  • Impact of endovascular treatment of atherosclerotic renal artery stenosis on endothelial function and arterial blood pressure. (
  • The modest blood pressure benefit directly assignable to renal denervation should be balanced with unresolved safety issues, such as potentially increased risk of renal artery stenosis after the procedure (more than ten cases reported up to now, most of them in 2014), unclear long-term impact on renal function and lack of morbidity-mortality data. (
  • Klippel-Feil syndrome, renal artery stenosis, and arterial hypertension. (
  • We report one patient with Klippel-Feil (KFS) syndrome, other associated anomalies, uncontrolled arterial hypertension, and renal artery stenosis. (
  • Because this patient underwent for surgical revascularization with unsuccessful result, all proposed way of treatments are revised, and we have hypothesized that probably for patients with KFS and unilateral renal artery stenosis, medical treatment with ACE inhibitors can provide more benefits than surgical revascularization or percutaneous transluminal angioplasty. (
  • renal artery stenosis. (
  • We present a young patient with Klippel-Feil syndrome (KFS) plus a wide variety of other deformities, uncontrolled hypertension, and unilateral renal artery stenosis. (
  • The management of renal artery stenosis shows some controversial aspects that we will discuss in relation with the management of KFS. (
  • This can occur in tetralogy of Fallot purchase mildronate cheap treatment uveitis, in some patients with double-outlet right ventricle mildronate 250mg discount medications definitions, or in patients who have subpulmonic stenosis associated with a univentricular circulation. (
  • Angiogram shows superficial femoral artery occlusion on one side (with reconstitution of suprageniculate popliteal artery) and superficial femoral artery stenosis on other side. (
  • Transcatheter aortic valve implantation (TAVI) has emerged as an alternative to AVR in high-risk patients with AS ( 10-12 ), and implanted prostheses perform well compared with currently available surgical valves with respect to relief of aortic stenosis and post-procedural valve hemodynamics ( 13 ). (
  • In this issue of The Journal , Gigante, et al 1 propose to assess renal involvement in patients with systemic sclerosis (SSc) through the evaluation of both structural and hemodynamic US measurements, paying particular attention to the Doppler-measured renal resistive index (RRI) and its clinical significance. (
  • Based on this pioneering demonstration that the RRI is influenced by upstream factors rather than by merely intrarenal conditions, particular attention was subsequently paid by many authors to the possible relationship between RRI and markers of systemic vascular damage regardless of renal function or kidney impairment. (
  • This point of view is clear from the provocative way that Heine, et al entitled their article (2007): "Do Ultrasound Renal Resistance Indices Reflect Systemic Rather Than Renal Vascular Damage in Chronic Kidney Disease? (
  • 5 6 7 In isolated ophthalmic arteries, NO is an important modulator of vascular tone, 8 and systemic NO-synthase inhibition decreases choroidal blood flow in animals 9 and humans. (
  • Vascular responses after the intravenous administration of l -arginine were recently demonstrated to be a likely consequence of an increase in the endothelial production of NO. 15 Accordingly, we compared the effects of l -arginine and NO donation with nitroglycerin on systemic, retinal, and renal hemodynamics in patients with and those without microalbuminuria. (
  • Objective: Our objective was to determine the hemodynamic properties of S-nitrosocysteine on the pulmonary and systemic circulations to assess its potential utility as a pulmonary vasodilatory agent. (
  • Results: Low-dose S-nitrosocysteine infusion decreased mean pulmonary artery pressure (15%, P = .013) without a significant reduction in mean systemic artery pressure. (
  • Higher dose infusions reduce mean systemic pressure and lead to compensatory reductions in renal and mesenteric blood flow without a decrease in cardiac output. (
  • Elevated intra-abdominal pressure produces physiological changes in the haemodynamics by its effects on systemic vascular resistance, venous return and myocardial performance. (
  • We tested whether selective pharmacological renal artery vasodilation and active renal artery perfusion (ARP) could improve renal function without adverse effects on systemic blood pressure in a canine model of acute heart failure (AHF). (
  • In conclusion, ARP and selective renal vasodilation may effectively promote salt and water excretion in the setting of heart failure, particularly when systemic blood pressure is low. (
  • We hypothesized that restoration of renal perfusion, independent of increased total cardiac output or increased systemic blood pressure, could restore renal function and induce a natriuresis and diuresis. (
  • Since the two principal mechanisms contributing to renal dysfunction in AHF are renal arterial vasoconstriction and arterial hypotension, we reasoned that a locally delivered pharmacologic vasodilator (with minimal, potentially harmful systemic vasodilating effects) and direct active renal artery perfusion (ARP) could be two potentially complimentary approaches to address this problem. (
  • They described oliguria in patients with chronic liver disease in the absence of proteinuria and linked the abnormalities in renal function to disturbances present in the systemic circulation. (
  • Further studies in the following 2 decades demonstrated that renal failure occurred because of vasoconstriction of the renal circulation and intense systemic arteriolar vasodilatation resulting in reduced systemic vascular resistance and arterial hypotension. (
  • Multiple mechanisms are probably involved and include an interplay between disturbances in systemic hemodynamics, activation of the vasoconstrictor systems, and a reduction in the activity of the vasodilator systems. (
  • Doppler studies of the brachial, middle cerebral, and femoral arteries suggest that extrarenal resistance is increased in patients with HRS, while the splanchnic circulation is responsible for arterial vasodilatation and reduced total systemic vascular resistance. (
  • Typical hemodynamic pattern of end-stage liver disease (ESLD) patients includes high cardiac output (CO)/cardiac index (CI)-hyperdynamic circulation pattern, with normal-to-low mean blood pressure, variable central venous pressure (CVP), along with general arterial and venous vasodilatation due to substantially decreased systemic vascular resistance (SVR). (
  • Systemic (pulmonary artery catheter) and splanchnic (hepatic vein catheter and dye dilution) hemodynamics and arterial and hepatic venous lidocaine and MEGX concentrations were measured after a lidocaine bolus injection (1 mg/kg) before and 90 min after increasing cardiac output by at least 25% with dopamine. (
  • We found that the ovarian hormone relaxin is a potent vasodilator in the systemic and renal circulations, and that it contributes to the remarkable changes in the vasculature during pregnancy. (
  • The investigators hypothesise that Apelin will have more marked pulmonary haemodynamic effects than that observed in the systemic circulation. (
  • Blood flow through the left coronary artery is at a maximum during diastole (in contrast to the rest of systemic circulation , which has a maximum blood flow during systole . (
  • In this procedure, systemic venous return is rerouted directly to the pulmonary arteries, which serves to separate the systemic and pulmonary circulations. (
  • Nitroprusside reduces left ventricular diastolic pressure, left atrial pressure, pulmonary wedge pressure (pulmonary artery occlusive pressure), right atrial pressure, and pulmonary and systemic vascular resistance. (
  • Individual patients may experience an improvement in renal function as the intense systemic vasoconstriction is relieved, assuming hypotension is avoided. (
  • it converts angiotensinogen to angiotensin I. In atherosclerosis, plaque formation causes the narrowing of renal artery that drives renin secretion, resulting in renovascular hypertension and kidney damage 8 . (
  • Adenosine-dependent regulation of renal function in healthy and diseased kidney is mediated by activation of the four types of P1 purinergic adenosine receptors (A 1 AR, A 2A AR, A 2B AR, A 3 AR). (
  • Experimental evidence supports the notion that adenosine protects against ischemia-induced acute kidney injury by directly acting on renal endothelial and tubular A 1 AR. (
  • Total renal resistance decreased and renal blood flow (RBF) significantly increased with both drugs, while the distribution of cardiac output to the kidney remained depressed. (
  • For a long time, the role of RRI has remained confined to renal damage, and it has been used as an important marker to predict the progression of renal function in patients with chronic kidney disease (CKD), diabetes mellitus, or hypertension (HTN). (
  • The resistance index (RI) of the hepatic artery was measured by color Doppler on its main branch and renal artery RI was measured on the main renal, interlobar and cortical arteries of the right kidney . (
  • In the stenotic kidney, the hemodynamic impairment of the cortex is dissociated from the relatively preserved renal medulla, and the earliest effect on excretory function is observed in the distal nephron, where the fall in the amount of fluid reaching that segment is directly proportional to the renal arterial compromise. (
  • We have shown previously ( 10 , 11 , 12 ) that intrarenal hemodynamics ( i.e. , cortical and medullary volumes and blood flows) and concurrent segmental nephron dynamics ( i.e. , intratubular transit times and relative fluid concentrations) could be reliably quantified in the intact kidney, using electron-beam computerized tomography (EBCT). (
  • We examined basal hemodynamic and infilammatory factors linked to improved stenotic kidney (STK) function after percutaneous transluminal renal angioplasty in swine RAS. (
  • STK and contralateral kidney hemodynamics and function were evaluated by multidetector computed-tomography before and after acetylcholine challenge. (
  • AIM: The renal medulla plays an important role in the control of water and salt balance by the kidney. (
  • 10 By using l -arginine analogues as probes for the renal NO pathway, several studies have demonstrated that NO acts as a potent vasodilator in the kidney. (
  • BNP Tg showed less significant renal damage, when the kidney was severely-injuried, suggesting the protective role of natriuretic peptides in the kidney. (
  • The effect of insulin to stimulate both the RAS and NO in the renal vasculature is of particular interest given the key role of RAS/NO balance in renal physiology and pathophysiology ( 13 ) and the accumulating evidence that insulin resistance and hyperinsulinemia are risk factors for chronic kidney disease ( 14 - 16 ). (
  • Our findings suggest that insulin simultaneously stimulates vasoconstrictor and vasodilator mechanisms in the human kidney and that insulin-induced RAS activation modulates the renal vasodilator effect of insulin. (
  • We studied ischemic acute renal failure in 28 dogs by micropuncture, microsphere, morphologic, and whole kidney hemodynamic techniques, 18 to 24 hours after the renal artery was clamped (clamping time, 60 to 90 min). (
  • We conducted a study to test the hypothesis that dexmedetomidine could protect kidney function in patients undergoing CABG with extracorporeal circulation (ECC). (
  • The circulation of kidney becomes much compromised with increased intra-abdominal pressure. (
  • Acute kidney injury (AKI) (increase in serum creatinine by 0.3 mg/dL in less than 48 hour or an increase in serum creatinine by 50% from a stable baseline reading within 3 months) has been proposed to characterize renal dysfunction in patients with cirrhosis, in which type 1 HRS would be reclassified as HRS-AKI. (
  • Sometimes neurological problems due to craniocervical junction anomalies like Arnold Chiari malformations type I, platybasia, or basilar invagination can be seen, also genito-urinary problems such as: hydronephrosis, renal ectopia, renal agenesia, horseshoe kidney, double collecting system, and bilateral tubular ectasies. (
  • Functional picture of the canine kidney with collateral circulation. (
  • 5. IL-4/IL-13-mediated polarization of renal macrophages/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury. (
  • Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker, it was found that it has significant flaws in predicting renal function outcomes. (
  • In studies of mice models, a high-fat diet can induce greater injury to the kidney with renal ischemia-reperfusion as compared to mice with normal diet. (
  • Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice. (
  • This model is generated by the constriction of the renal artery using a clip 17 , 20 , 21 , therefore producing renal artery occlusion that results in an increase in renin expression and hypertension 17 , 19 , 20 , 21 . (
  • Renal hemodynamics in essential and renovascular hypertension. (
  • Electron-beam computerized tomography shows promise to noninvasively quantify, follow-up, and study changes in concurrent, in vivo intrarenal hemodynamics and segmental tubular function in renovascular hypertension. (
  • Although potentially reversible, cure of either hypertension or ischemic nephropathy is not always achieved even with restoration of renal blood supply, partly due to long-term intrarenal modifications ( 2 ). (
  • Patients with T2DM have abnormal central hemodynamics and greater propensity for exercise hypertension. (
  • 1 Abnormalities in renal hemodynamics are evident during the development of hypertension in young SHR. (
  • We have therefore compared the effects of low-dose l -arginine on renal hemodynamics between a similar young and healthy reference group and a group of elderly patients with type 2 diabetes, arterial hypertension, and elevated cholesterol levels. (
  • While electrical stimulation of baroreceptors and other interventional treatments of hypertension are already "knocking at the door", the premature and uncontrolled dissemination of renal denervation should remain an example of what should not be done, and trigger radical changes in evaluation processes of new devices by national and European health authorities. (
  • In 2009, Krum and colleagues [ 1 ] published a non-randomised proof-of-concept study, testing percutaneous radiofrequency catheter-based renal sympathetic denervation (RDN) as a novel treatment of resistant hypertension in a cohort of 45 patients. (
  • We examined if Ang1-7 would attenuate the development of hypertension, renal vasoconstriction, and decreased natriuresis in AngII-infused rats and evaluated the mechanisms involved. (
  • Portopulmonary hypertension is common in cirrhosis with refractory ascites, possibly due to excess endothelin 1 in the pulmonary circulation. (
  • 10, 11 Portal hypertension and cirrhosis are thought to contribute to the pathogenesis of pulmonary hypertension by shunting hypertension inducing substances, not metabolised by the liver, into the pulmonary circulation. (
  • What is the impact of catheter-based renal sympathetic denervation (RD) on central hemodynamics in patients with resistant hypertension? (
  • It is well-known that cardiac hypertrophy and arterial and renal dysfunction are serious complications of hypertension. (
  • These results suggest that 606A not only has a hypotensive effect but also protects cardiac, renal and vascular tissues from complications of hypertension. (
  • Patients with T2DM are more likely to have increased aortic stiffening, which can limit the buffering capacity of large central arteries and is hypothesized to expose the glomerular capillaries to damage from excess pulsatile stress. (
  • These results indicate the presence of an endogenous NADPH oxidase-dependent O 2 − generation that may modulate renal function by scavenging NO. Angiotensin II infusion reduced renal blood flow, glomerular filtration, sodium excretion, and NO levels in a dose-dependent manner. (
  • However, the detection of COX-2 in the kidneys under normal conditions or under conditions of impaired renal blood flow (RBF) and glomerular filtration rate (GFR) has attracted the attention of researchers to the role of these drugs in maintaining renal function 4 - 6 . (
  • Renal vascular resistance is increased and glomerular filtration rate and RBF are reduced, compared with normotensive WKY. (
  • Renal blood flow and glomerular filtration rate decreases because of increase in renal vascular resistance, reduction in glomerular filtration gradient and decrease in cardiac output. (
  • Other parameters of renal hemodynamics such as glomerular filtration rate (5 ± 5 vs. 4 ± 4%) and filtration fraction (−1 ± 8 vs. −1 ± 9%) were not significantly different between diabetic and reference subjects, too. (
  • Changes of renal plasma flow (RPF), glomerular filtration rate (GFR), and even the development of proteinuria due to such changes are the consequence of endothelial dysfunction of the renal vasculature. (
  • In contrast, an inverse relationship exists between the activity of these 2 systems and renal plasma flow (RPF) and the glomerular filtration rate (GFR). (
  • Ang1-7 has been reported to induce vasodilation or vasoconstriction, and also to antagonize pressor responses to AngII.8-11 Assessment of Ang1-7 effects on rat renal vasculature showed that while Ang1-7 per se had no vasoactive actions, it prevented AngII-induced constriction of isolated renal arteries in vitro.12 Reports on Ang1-7 effects on renal glomerular arterioles are conflicting. (
  • Somewhat to our surprise, we found that baseline renal plasma flow (RPF) and glomerular filtration rate were highly and positively correlated with the renal hemodynamic response to blocking the renin-angiotensin system (RAS) with irbesartan in patients with type 2 diabetes and nephropathy ( Fig. 1 ). (
  • Barrett RJ, Droppleman DA (1993) Interactions of adenosine A1 receptor-mediated renal vasoconstriction with endogenous nitric oxide and ANG II. (
  • Aim: We tested the hypothesis that KV7 channels contribute to basal renal vascular tone and that they participate in agonist-induced renal vasoconstriction or vasodilation. (
  • Abstract Previous blood flow studies demonstrated that arginine vasopressin (AVP) produces exaggerated renal vasoconstriction in young spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto control rats (WKY). (
  • The purpose of the present study was to determine the role of postreceptor calcium signaling pathways in AVP-induced renal vasoconstriction in vivo. (
  • Coadministration of nifedipine with AVP produced dose-dependent inhibition of the AVP-induced renal vasoconstriction. (
  • 3 Also, administration of PGE 2 or PGI 2 into the renal circulation effectively attenuates the vasoconstriction elicited by Ang II in WKY but is without effect in young SHR. (
  • The hallmark of HRS is renal vasoconstriction, although the pathogenesis is not fully understood. (
  • Renal vasoconstriction occurs in the absence of reduced cardiac output and blood volume, which is in contrast to most clinical conditions associated with renal hypoperfusion. (
  • The RAAS and SNS are the predominant systems responsible for renal vasoconstriction. (
  • This seems paradoxical in that an opposite result would have been expected if angiotensin-dependent renal vasoconstriction was responsible for the renal vasodilator response to RAS blockade. (
  • The relationship was counterintuitive in that an opposite relationship would have been anticipated if angiotensin-dependent renal vasoconstriction was responsible for the renal vasodilator response to the angiotensin antagonist. (
  • According to this simple model, increased angiotensin-dependent renal vasoconstriction would both lower baseline RPF and enhance the response to the blocker. (
  • The same authors subsequently tried to assess the effect of acute changes in both renal vascular resistance (RVR) and pulse pressure on RRI measured by Doppler US in rabbit kidneys. (
  • 2 The reason for the elevated renal vascular resistance is not completely understood, although a combination of defects is probably involved. (
  • Decreased arterial pressure leads to baroceptor-mediated increase in sympathetic activity and activation of renin-angiotensin-aldosterone system by the juxtaglomerular apparatus leading to increased peripheral and renal vascular resistance. (
  • As a result, renal blood flow declines due to both decreased arterial pressure and increased renal vascular resistance. (
  • Although the pattern of increased renal vascular resistance and decreased peripheral resistance is characteristic of HRS, it also occurs in other conditions, such as anaphylaxis and sepsis. (
  • 30% of patients under the effect of nonpulsating blood flow developed relatively pronounced renal dysfunction (a decrease in the total GFR and/or GRF of one of the kidneys by 15% and more as compared with the initial level). (
  • The results showed that the endothelium-dependent vascular responses of the retinal and intrarenal arteries as well as the brachial artery were impaired in diabetic patients before the clinical manifestation of diabetic nephropathy, and suggest that endothelial dysfunction in these arteries is associated with hyperglycemia in these patients. (
  • 13 Although endothelial dysfunction is assumed to contribute to altered ophthalmic and intrarenal circulation and the development of diabetic retinopathy and nephropathy, 7 14 there has been little research regarding endothelial function in both the retinal and renal arteries of type 2 diabetic patients. (
  • 11 used the concentration of creatinine in ischemia/reperfusion models in rats and showed that parecoxib increases renal dysfunction and injury associated with this form of renal stress. (
  • In the renal vasculature, endothelial dysfunction influences the regulatory capabilities of afferent and efferent arterioles ( 7 ). (
  • Accordingly, endothelial dysfunction of the renal vasculature is considered an early step in the development of human diabetic nephropathy ( 8 ). (
  • The present study was conducted to gain further insight into the importance of endothelial dysfunction of the renal vasculature for the development of renal disease but also into the validity of l -arginine infusions as a tool to assess endothelium-dependent vasodilation of the renal vasculature. (
  • Although considerable advances have been made in medical and surgical treatments of acute heart failure (AHF), renal dysfunction commonly occurs in this setting and contributes importantly to the morbidity and mortality associated with the management of these patients. (
  • Approximately 50% of male patients with chronic renal failure treated by hemodialysis complain of sexual dysfunction of some degree or another (1). (
  • Procci WR, Hoffman KI, Chatterjee SN: Persistent sexual dysfunction following renal transplantation. (
  • Persistent dysfunction of regenerated endothelium after balloon angioplasty of rabbit iliac artery. (
  • Determinants of left ventricular hypertrophy and systolic dysfunction in chronic renal failure. (
  • Liver and renal dysfunction are reported in these patients and have a direct effect on morbidity and mortality. (
  • L-arginine is also used for recurrent pain in the legs due to blocked arteries (intermittent claudication), decreased mental capacity in the elderly (senile dementia ), erectile dysfunction (ED), and male infertility . (
  • Purpose To study the effect of sildenafil, which is an effective agent for the treatment of erectile dysfunction, on ocular haemodynamics. (
  • 2. FSTL3 is increased in renal dysfunction. (
  • 3 days), high dose (≥3 mcg/kg/min) administration can lead to cyanide and thiocyanate toxicity, particularly in the setting of renal dysfunction, causing some to avoid this agent. (
  • However, administration of parecoxib may affect renal function in an unknown way, especially in situations of diminished renal perfusion such as dehydration, hemorrhage, heart failure, low-salt diets, and stroke 3 , 8 , 9 . (
  • In view of of an abnormal myocardial perfusion stress test and known coronary artery disease having had coronary stenting on 2/22/18, recommend cardiac catheterization to assess coronary status and to undertake appropriate treatment. (
  • With baseline RPF as the independent variable, the relationship between baseline renal perfusion and the response to blockers in the patients with type 1 diabetes who were free of nephropathy was in striking accord to that found in the patients with type 2 diabetes and nephropathy ( Fig. 3 ). (
  • Baseline renal perfusion at the end of glucose infusion was a major determinant of the renal vasodilator response to captopril ( Fig. 4 ). (
  • Septic shock is a syndrome marked by altered hemodynamics decreased tissue perfusion and loss of cellular energy. (
  • Advanced study of the physiology, pharmacology and pathophysiology of the coronary circulation using contemporary methods is emphasized. (
  • As the transition from fetal to postnatal circulation is completed, symptoms specific to the physiology of the defect become evident. (
  • American Journal of Physiology: Renal Physiology. (
  • The method requires catheterization of both the renal artery and the renal vein, a single injection of dye into the renal artery, and recording of the venous dilution curve by means of a cuvette densitometer. (
  • The observed impaired renal venous flow is correlated with less diuretic efficiency. (
  • Intrarenal venous flow patterns may be of interest for evaluating renal congestion. (
  • There is increasing recognition that the capacity of the kidneys to compensate for fluid overload relates not only to the underlying intrinsic renal function but also to renal blood flow, in part influenced by increased venous pressure (1) . (
  • In this circumstance, the lower body is perfused by the ductus arteriosus carrying pulmonary venous blood via the left ventricle to the pulmonary artery then to the descending aorta. (
  • This study sought to determine the relationship between light-moderate exercise central hemodynamics (including aortic reservoir and excess pressure) and exercise-induced albuminuria. (
  • Hemodynamics recorded included brachial and central blood pressure (BP), aortic stiffness, augmented pressure (AP), aortic reservoir pressure, and excess pressure integral (P excess ). (
  • 12 showed that parecoxib attenuates renal function impairment during porcine suprarenal aortic cross-clamping. (
  • Measurement of aortic PWV provides some of the strongest evidence concerning the prognostic significance of large artery stiffening. (
  • Upper body cyanosis with pink lower extremities may indicate transposition of the great arteries with an aortic arch obstruction. (
  • In the rat, renal (14), mesenteric and aortic flows (15) were measured with Transonic probes and compared with known blood/saline flows obtained from pump-perfused circuits (15) or by clearance of p-aminohippuric acid (14). (
  • Objectives Valve hemodynamics and clinical outcomes among patients with a small aortic annulus who underwent transcatheter aortic valve implantation (TAVI) were examined. (
  • Conclusions In high-risk patients with severe AS and a small aortic annulus, TAVI is associated with good post-procedural valve hemodynamics and clinical outcomes. (
  • Radial artery applanation tonometry and pulse wave analysis were used to derive central aortic pressure and hemodynamic indices at baseline and 1, 3, and 6 months after ablation. (
  • Central aortic blood pressure is a strong predictor of adverse cardiovascular outcomes (CAFÉ study, Circulation, 2006), and this study confirms the salutary impact of RD on both central and peripheral blood pressure. (
  • The dominant effect of an elevation of plasma adenosine in the renal vasculature is an A 2A AR- and A 2B AR-mediated vasodilatation that increases global as well as medullary renal blood flow and is in part endothelium-dependent. (
  • We examined the relationships between insulin-induced renal vasodilation, insulin-induced renin secretion, and insulin-induced sensitization of the renal vasculature to ARB. (
  • The maintenance of RBF in the postischemic phase may occur by utilization of the autoregulatory reserve of the renal vasculature. (
  • Endothelium-dependent vasodilation of the renal vasculature cannot be easily assessed, but infusion of l -arginine, the substrate of endothelial nitric oxide synthase, leads to an increase in renal plasma flow (RPF) in humans. (
  • CONCLUSIONS - l -Arginine-induced vasodilation of the renal vasculature is not different between a group of hypertensive diabetic patients and a young, healthy reference group. (
  • The assessment of endothelium-dependent vasodilation of the renal vasculature in humans is difficult. (
  • Using low-dose l -arginine infusions, we did not observe a difference in l -arginine-induced vasodilation of the renal vasculature between middle-aged patients with hypercholesterolemia and a young and healthy reference group ( 15 ). (
  • We also observed that, unexpectedly, relaxin was equally potent in the vasculature of males, and to explain this finding we hypothesized the existence of local relaxin ligand-receptor expression and function in arteries, which we subsequently supported with both molecular and functional evidence. (
  • Dopaminergic receptor-mediated effects in the mesenteric vasculature and renal vasculature of the chronically instrumented newborn piglet. (
  • Assessment of renal and hepatic hemodynamics in cirrhosis of liver. (
  • We studied the hepatic and renal hemodynamics by color Doppler in patients with liver cirrhosis in relation to the presence and severity of ascites . (
  • Hepatic artery RI were 0.68 (0.07), 0.68 (0.1), 0.81 (0.04), 1.0 (0.12) in control subjects and cirhotics with no ascites , responsive ascites and refractory ascites , respectively. (
  • Hepatic artery RI is higher in cirrhotics and is related to presence and severity of ascites . (
  • 5 Patients living with Fontan circulation, in particular, are prone to chronic renal insufficiency, hepatic fibrosis and cardiac cirrhosis. (
  • However, we recently demonstrated that renal blood flow and total hepatic blood flow were preserved in conscious dogs treated with NMA. (
  • No active bleeding at cath site in the right common femoral artery. (
  • Balloon angioplasty of the right common femoral artery for bleeding. (
  • The right groin was infiltrated with xylocaine and the right common femoral artery was entered and a sheath was placed in the artery. (
  • Sheath angiography was done at the beginning of the procedure and it indicated no abnormality and the sheath insertion site was in the common femoral artery. (
  • To exclude significant bleeding, angiography was undertaken from the contralateral side.The left groin was infiltrated with xylocaine and with US aid and using micropuncture technique, the left common femoral artery was entered. (
  • Subsequently angiography by hand injection of the iliac arteries and the right common femoral artery was done. (
  • Balloon dilation of the right common femoral artery was done using a 6 x 60 mm Abbot's Armada balloon which was inflated for 3 minutes, just to tamponade any possible oozing that is not readily visible. (
  • Friedenberg MJ, Perez CA: Collateral circulation in aorto-ilio-femeral occlusive disease: As demonstrated by a unilateral percutaneous common femoral artery needle injection. (
  • In additional experiments, anesthetized animals with catheterized left femoral arteries and veins were administered a dose-range of norepinephrine (0.1-1 microg/kg) as bolus intravenous injections. (
  • The image below depicts a superficial femoral artery occlusion. (
  • In the rat, transit-time flowmetry has been widely used to quantitate blood flow in gastric (11,12), renal (13,14), mesenteric (13,15), carotid (13), and femoral (13) arteries and in the aorta (13,15) but only under acute conditions. (
  • Abebe W, Hussain T, Olanrewaju H et al (1995) Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery. (
  • In seeming contradiction, acute hyperinsulinemia also induces nitric oxide (NO)-dependent renal vasodilation ( 12 ). (
  • Renal cortical nitric oxide (NO) was measured electrochemically in vivo. (
  • because these effects are potentiated by NO synthesis inhibition, it has been postulated that the renal actions of superoxide are buffered by nitric oxide. (
  • 15 Therefore, it seems that the balance between superoxide and nitric oxide is important in controlling renal function, but the in vivo effects of Ang II affecting this equilibrium and contributing to modulate renal excretion and hemodynamics are unknown. (
  • Infusions of l -arginine, the substrate of endothelial nitric oxide synthase, and subsequent measurement of changes of renal hemodynamics have been used for this purpose ( 10 - 16 ). (
  • This suggests a link between the renal vasodilator response, mediated by nitric oxide (NO), and the activation of the intrarenal RAS. (
  • Insulin stimulates the renin-angiotensin system and induces renal vasodilation. (
  • Insulin-induced activation of the renin-angiotensin system modulates insulin-induced renal vasodilation in healthy individuals. (
  • We sought to examine the relationship between insulin-induced renal vasodilation and insulin-induced activation of the RAS. (
  • In an animal model, impaired endothelium-dependent vasodilation of the renal artery has been found in diabetic rabbits but not in controls ( 9 ). (
  • Kuczeriszka, Marta;Kompanowska-Jezierska, Elżbieta;Sadowski, Janusz;Prieto, Minolfa C;Navar, L Gabriel 2018-04-01 00:00:00 Abstract BACKGROUND Indirect evidence suggests that angiotensin 1-7 (Ang1-7) may counterbalance prohypertensive actions of angiotensin II (AngII), via activation of vascular and/or renal tubular receptors to cause vasodilation and natriuresis/diuresis. (
  • The drug produces renal vasodilation with an increase in sodium excretion. (
  • In recent studies, the efficacy of catheter-based percutaneous transluminal renal angioplasty with stent placement has been called into question. (
  • Interventions targeting renal artery stenoses have been shown to lower blood pressure and preserve renal function. (
  • Furthermore, in porcine epicardial coronary arteries, stenoses have been successfully achieved through percutaneous deployment of intracoronary, balloon-expandable, local-irritant stents, which lead to a proliferative neointimal response and progressive luminal area narrowing ( 8 , 9 ). (
  • Single or multiple arterial stenoses produce impaired hemodynamics at the tissue level in patients with PAOD. (
  • Coronary angiography indicates diffuse multifocal tandem 30-50% stenoses throughout the course of the posterior descending coronary artery with a visible dissection plane. (
  • Pulmonary circulation transvascular fluid fluxes ( J VA ) are attributed to changes in hydrostatic forces and erythrocyte volume (EV) regulation. (
  • Besides, these patients also demonstrated significant changes in the half-clearance of the radiopharmaceutical from the renal parenchyma and the index of cortical retention of the indicator on the both sides. (
  • The renin-angiotensin system plays a critical role in the regulation of renal function and arterial pressure. (
  • In all three groups, baseline renal plasma flow (RPF) was positively correlated with the RPF response to blocking the renin-angiotensin system (RAS). (
  • Cardiac output, right and left heart pressures, heart rate, Pao 2 , and iliac, renal, coronary, and mesenteric blood flow rates were recorded at baseline and at each infusion dose of S-nitrosocysteine. (
  • Omnifush catheter and angled glide wire, the catheter was advanced into the left common iliac artery and contrast injection was done. (
  • It is suggested that this increase might be due to vascular insufficiency resulting from ligation of both internal iliac arteries (3). (
  • The objective of the present study was to validate the transit-time technique for long-term measurements of iliac and renal blood flow in rats. (
  • Instantaneous changes of iliac and renal flow during exercise and recovery were accurately measured by the transit-time technique. (
  • Selective angiogram of the right exernal iliac artery demonstrates irregular beading consistent with fibromuscular dysplasia. (
  • Because adenosine production increases in hypoxia, the issue of a role of the nucleoside in the renal injury following ischemia reperfusion has been studied extensively. (
  • Moreover, adenosine protects against renal ischemic reperfusion injury by the anti-inflammatory effect of enhancing the activity of regulatory T cell and by attenuating the inflammatory injury produced by neutrophils via A 2 AR activation. (
  • Throughout the 60-min pericardial tamponade and the 180-min reperfusion, macro hemodynamics, renal circulation and the mesenteric macro- and micro-circulatory parameters were monitored. (
  • Renal surgery and coronary artery bypass grafting can produce renal ischemia and reperfusion injury. (
  • The mesenteric artery flow (from 355.5±112.4 vs 182.0±59.1 mL/min) and renal arterial flow (from 159.63±50.7 vs 35.902±27.9 mL//min) and the micro-circulation of the ileum was reduced. (
  • FMD occurs in middle aged (mean age 52 years old) women (91%) and is widely known to affect renal, cerebral, mesenteric and other peripheral arteries, but is less well known to affect coronary arteries. (
  • OBJECTIVE To determine the effects of stimulation of vascular dopaminergic receptor subtype 1 (dopamine-1) receptors in the renal and mesenteric vascular beds of a neonatal model. (
  • The aim of the current study was to determine whether endothelial function in the retinal and renal arteries is impaired in type 2 diabetes mellitus. (
  • 7. Specific endothelial heparin-binding EGF-like growth factor deletion ameliorates renal injury induced by chronic angiotensin II infusion. (
  • The method was evaluated in 11 normal subjects, eight patients with acute anuric renal failure, and 13 patients with chronic renal disease. (
  • Renal effects of nitroprusside and hydralazine in patients with congestive heart failure. (
  • The acute effects of nitroprusside infusion and intravenous hydralazine on renal hemodynamics and function were evaluated in nine male patients with severe, low cardiac output, congestive heart failure (CHF). (
  • Investigators have documented an increase in renal artery resistance in cirrhotic patients . (
  • Renal RI was significantly higher than in control subjects at all three levels in patients with responsive and refractory ascites , being higher in those with refractory than responsive ascites . (
  • In control subjects and patients with no ascites or responsive ascites the renal RI decreased from hilum to the outer parenchyma. (
  • There is currently no noninvasive tool capable of predicting which patients with ischemic nephropathy will have an improvement in renal function after intervention ( 2 ). (
  • These tools may be useful for identification of patients likely to improve renal function after revascularization. (
  • Methods: Human non-malignant renal tissue was obtained from patients undergoing nephrectomy due to renal cell carcinoma. (
  • OBJECTIVE: By means of scintigraphic methods to assess alterations in cardiopulmonary haemodynamics and renal functional activity in patients with coronary artery disease (CAD) after endured coronary artery bypass grafting (CABG) performed in conditions of extracorporeal circulation (EC) and on the functioning heart. (
  • All patients were subdivided into 2 groups: Group One consisting of 20 patients subjected to CABG performed on the beating heart with the use of myocardial "stabilizer" "Acrobat" (Study Group) and Group Two also comprising 20 patients but undergoing surgery with the use of extracorporeal circulation (Comparison Group). (
  • RESULTS: In the early postoperative period after CABG, the patients of the both groups were found to have a significant increase in the minute volume, cardiac index, and circulation efficiency coefficient, accompanied by a significant decrease in the period of half-emptying of the left ventricle, thus suggesting improvement of LV contractility. (
  • Unlike the Comparison Group, in patients without EC the average values of the majority of parameters of renal filtration activity underwent no statistically significant alterations as compared with the baseline (prior to CABG) values. (
  • We examined the effects of an intravenous infusion of l -arginine and a sublingual administration of nitroglycerin on the brachial, retinal, and interlobar arterial hemodynamics in 20 type 2 diabetic patients (10 with normoalbuminuria and 10 with microalbuminuria) and 10 aged-matched control subjects. (
  • Associated vascular lesions in patients with spontaneous coronary artery dissection. (
  • Influence of plaque volume on hemodynamic response and stress hormone release in patients undergoing carotid artery stenting. (
  • Patients with normal renal function and scheduled for elective CABG were randomized to placebo or to infusion of dexmedetomidine to achieve a pseudo steady-state plasma concentration of 0.60 ng/ml. (
  • Use of intravenous dexmedetomidine did not alter renal function in this cohort of relatively low-risk elective CABG patients but was associated with an increase in urinary output. (
  • We have examined the effect of l -arginine infusion on renal hemodynamics in hypertensive patients with type 2 diabetes. (
  • RESULTS - l -Arginine infusion similarly influenced renal hemodynamics in patients and reference subjects: RPF increased by 7 ± 11 and 7 ± 11% in diabetic and reference subjects, respectively ( P = NS). (
  • Still, renal denervation is supported by a strong rationale and is occasionally followed by major blood pressure responses in at-risk patients who may otherwise have remained uncontrolled. (
  • While successful renal transplantation improves sexual performance of a large number of these patients, close to 30% continue to experience poor sexual function. (
  • Abrams HS, Hester LR, Sheridan WF, Epstein GM: Sexual functioning in patients with chronic renal failure. (
  • Zadeh JA, Koutsaimanis KG, Roberts AP: The effect of maintenance hemodialysis and renal transplantation on plasma testosterone levels of male patients in chronic renal failure. (
  • Dagher F.J., Billet A., Queral L. (1984) Bilateral renal transplantation: effect on pelvic hemodynamics and sexual function in male patients. (
  • OBJECTIVE To determine whether increased plasma concentrations of endothelin-1 (ET-1) and big endothelin (BET) play a role in the regulation of coronary circulation in patients with idiopathic dilated cardiomyopathy (IDCM). (
  • CONCLUSIONS The coronary circulation in patients with IDCM is exposed to an increased endothelin load. (
  • between the anti-Xa activity at 3 hrs and the dose of norepinephrine (r =.12, p =.7).Critically ill patients with normal renal function demonstrated significantly lower anti-Xa levels in response to a single daily dose of subcutaneous enoxaparin when compared with medical patients in the normal ward. (
  • Its multicomponent nature, sometimes a very short time resolution in the decision-making process, poorly predictable course of patients reactions, overall instability with rapid, oftentimes detrimental and life-threatening changes makes management of patient's hemodynamics an extremely challenging and complicating task. (
  • Clinical and echocardio-graphic disease in patients starting end-stage renal disease therapy. (
  • More recently, we identified a similar relationship in patients with type 1 diabetes who received both an angiotensin II antagonist, candesartan, and an ACE inhibitor, captopril, as part of a protocol designed to ascertain whether renal vascular response to ACE inhibition primarily reflected a reduction in angiotensin II formation, which it did ( 2 ). (
  • Based on the response to captopril, we divided the patients into a normal response group, in which the renal vasodilator response to captopril was equal to that in the normal subjects, and an accentuated response group, in which the renal vasodilator response to captopril and candesartan was enhanced ( Fig. 2 ). (
  • RPF, once again, was elevated in those patients with enhanced renal vasodilator response to the two blockers. (
  • Prompted by observations in type 1 diabetic patients, we returned to the studies on the renal response to glucose infusion in normal volunteers and found that the same relationships existed. (
  • This study aims to investigate whether the Model for End-stage Liver Disease eXcluding INR score (function of creatinine and total bilirubin, MELD-XI) predicts risk for cardiac mortality or transplantation in patients with Fontan circulation. (
  • 5 These patients are demographically similar to those initially presenting with renal or cerebral artery FMD. (
  • In the largest retrospective study to date of 189 patients who presented with SCAD, PCI for stable SCAD was associated with high rates of complications and emergency CABG, compared to those who received medical management, even in patients with preserved coronary artery flow. (
  • Wolsk E, Kaye D, Borlaug BA , Burkhoff D, Kitzman DW, Komtebedde J, Lam CSP, Ponikowski P, Shah SJ, Gustafsson F. Resting and exercise haemodynamics in relation to six-minute walk test in patients with heart failure and preserved ejection fraction. (
  • Thus, it was difficult to attribute the influence of baseline renal hemodynamic state to the stage of the process, as we had previously done. (
  • After initial dosing to offer relief for severe dyspnea, continued nitroprusside administration is most effective and safest with hemodynamic monitoring with an indwelling arterial line and oftentimes a pulmonary artery flow-directed catheter. (
  • These observations indicate that about one third of the AVP-induced constriction of renal resistance vessels is mediated by voltage-dependent L-type calcium channels responsive to the dihydropyridine nifedipine. (
  • Renal failure is common in heart failure due to renovascular constriction and hypotension. (
  • Doppler studies on the fetal renal artery in the severely growth-restricted fetus. (
  • article{Stigter2001DopplerSO, title={Doppler studies on the fetal renal artery in the severely growth-restricted fetus. (
  • Longitudinal reference intervals for Doppler velocimetric parameters of the fetal renal artery correlated with amniotic fluid index among low-risk pregnancies. (
  • Evaluation of blood flow in the fetal renal artery between the 22nd and 38th week in normal pregnancies]. (
  • In anuric renal failure the total renal blood flow averaged 55% of normal and did not increase significantly during the subsequent polyuria. (
  • However, recent large randomized studies such as the ASTRAL (Angioplasty and Stent for Renal Artery Lesions) and CORAL (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) trials failed to show a beneficial effect of percutaneous transluminal renal angioplasty with stent placement (PTRAS) over medical therapy alone regarding blood pressure reduction, prevention of renal function deterioration, or cardiovascular outcome (3,4) . (
  • Despite the lack of superiority of PTRAS in recent trials, a considerable range of smaller clinical studies have demonstrated that PTRAS was successful in improving blood pressure control and renal function (6-16) . (
  • Four weeks after percutaneous transluminal, renal angioplasty blood pressure was normalized in all animals, but STK-GFR improved in 10 of 15 (ΔGFR =+22.0±8.5 mL/min). (
  • Renal blood flow (RBF) was measured using an ultrasonic flow probe. (
  • Outer medullary descending vasa recta (OMDVR) are microscopic vessels providing blood flow to the renal medulla. (
  • Endothelium-derived NO has also been shown to regulate renal and ocular blood flow. (
  • Before the artery was clamped, renal blood flow (RBF) averaged 3.49 ± (SEM) 0.23 ml/min x g and was not significantly different (3.70 ± 0.34 ml/min x g) 18 hours after the ischemic episode. (
  • Renal blood flow (RBF) was measured by electromagnetic flowmetry in anesthetized, water-loaded, 8-week-old WKY and SHR pretreated with indomethacin to avoid interactions with prostaglandins. (
  • Verres needle or the trocar, may directly puncture the arteries or blood flow across an opening in an injured vessel may sometimes draw gas into the vessel and leads to gas embolism. (
  • The use of a sound methodology, including randomisation and blinded endpoint assessment was enough to see the typical 25-30 mmHg systolic blood pressure decrease observed after renal denervation melt down to less than 3 mmHg, the rest being likely explained by Hawthorne and placebo effects, attenuation of white coat effect, regression to the mean and other physician and patient-related biases. (
  • This function depends on the elasticity of the arteries and stiffened arteries require a greater amount of force to permit them to accommodate the volume of blood ejected from the heart (stroke volume). (
  • Modulating Role of Ang1-7 in Control of Blood Pressure and Renal Function in AngII-infused. (
  • METHODS AngII, alone or with Ang1-7, was infused to conscious Sprague-Dawley rats for 13 days and systolic blood pressure (SBP) and renal excretion were repeatedly determined. (
  • In anesthetized normotensive or AngII-induced hypertensive rats, Ang1-7 infusion transiently increased mean arterial pressure (MABP), transiently decreased renal blood flow (RBF), and caused increases in UNaV and V. In normotensive rats, candesartan prevented the Ang1-7-induced increases in MABP and UNaV and the decrease in RBF. (
  • increases renal blood flow and decreases microalbuminuria (3,4). (
  • Despite incessant and plentiful research, investigating literally every imaginable aspect and angle of the anesthesia and perioperative care for liver transplant recipient, and myriad of publications coming out every year, no consensus has been reached so far as for the best choice of anesthesia induction and maintenance, intraoperative hemodynamics management, fluid and blood products transfusion, patient's monitoring, and more. (
  • Despite a consistent and narrow blood glucose level of 150-170 mg/dl, a wide range of renal vasodilator responses occurred with hyperglycemia. (
  • L-arginine is used for heart and blood vessel conditions including congestive heart failure (CHF), chest pain , high blood pressure , and coronary artery disease . (
  • During the following 83 years, this way of studying the cerebral blood circulation has not significantly changed. (
  • Will it actually add relevant information when we colorize the blood flow velocity in cerebral arteries and visualize the arteriovenous malformation (AVM) feeder in red and the draining veins in blue? (
  • Increasing renal blood flow: low-dose dopamine or medium-dose norepinephrine. (
  • Concepts of exercise stimulus, quantification of work, and in vivo responses and adaptations will be fundamental to studies of cellular and molecular mechanisms of myocardial and coronary artery responses and adaptations to exercise. (
  • 2,3 SCAD is a non-atherosclerotic abnormality of the coronary artery characterized by development of a dissection plane within the arterial wall resulting in an intramural hematoma that can cause dynamic flow obstruction and result in myocardial infarction, congestive heart failure, and sudden death. (
  • Nitroprusside had a more profound effect on pulmonary artery pressure, while hydralazine produced a greater elevation in cardiac output. (
  • Cardiac output (Q) and pulmonary artery pressure (P AP ) were measured. (
  • mean age 54.5 (1.4) years) with biopsy proven cirrhosis and refractory ascites underwent angiographic measurements of pulmonary and splanchnic haemodynamics. (
  • This was a double-blind, randomized, parallel-group study designed to compare dexmedetomidine, administered as a continuous intravenous (i.v.) infusion at rates needed to achieve a pseudo steady-state plasma concentration of 0.60 ng/ml, with placebo in terms of renal effects. (
  • However, others and we have shown that the effects of high-dose l -arginine infusion on renal hemodynamics are at least in part unspecific ( 10 , 11 ). (
  • It was initially proposed by Gosling and King 2 and Pourcelot 3 in 1974 to identify the renal vascular diseases through the noninvasive measurement of intrarenal hemodynamics indirectly related to changes in arteriolar resistance. (
  • Over the years many authors have tried to find a correct interpretation of the RRI, and several studies have shown that it was minimally affected by intrarenal resistance: unexpectedly, the correlation between RRI values and changes in renal vascular impedance proved to be weak. (
  • The intrarenal resistance index (RI) ( Figure 1 ) reflects renal arterial flow and changes in response to alterations in arterial resistance and capacitance. (
  • In the present study, the response to intrarenal infusions of a NADPH oxidase inhibitor (apocynin) and a SOD mimetic (tempol) were evaluated to exclude that sources of superoxide other than NADPH oxidase may regulate renal function. (
  • In five dogs, selective intrarenal (IR) papaverine (1, 2, and 4 mg/min) was administered into the left renal artery. (
  • 3 combinations of KFS and vertebral artery dissection, 4 RAS and aneurysmatic dilatation of internal carotid artery in tuberous sclerosis 5 among other combinations have been reported. (
  • In 2010, we still visualize the neurovascular system by injecting radiopaque contrast medium through a catheter that is directly placed into the carotid artery. (
  • For common carotid measurements, the left distal common carotid artery near and far walls were imaged, and lines were electronically drawn along a 1-cm segment of the lumen-intima interface and the media-adventitia interface. (
  • Mean values for diameter measures were 3.6 mm for brachial artery interadventitial diameter, 6.8 mm for carotid artery interadventitial diameter, and 5.5 mm for carotid artery lumen diameter. (
  • Mean carotid artery IMT was 0.6 mm. (
  • It is conceivable that, like the coronary circulation, functional measurements may better predict therapeutic efficacy of percutaneous transluminal renal angioplasty with stent placement. (
  • Methods and Results: Fifteen pigs after 6 weeks of hemodynamically significant RAS were studied before and 4 weeks after technically successful percutaneous transluminal renal angioplasty+stenting. (
  • We performed the hyperinsulinemic euglycemic clamp technique in healthy volunteers and compared the renal vasodilator response to angiotensin receptor blockade (ARB) during hyperinsulinemia with the response on a control study day. (
  • This makes HRS a unique pathophysiological disorder that provides possibilities for studying the interplay between vasoconstrictor and vasodilator systems on the renal circulation. (
  • We attributed the opposite relationship, i.e., a larger renal vasodilator response to the angiotensin antagonist in the patient with the highest baseline RPF, to an influence of the stage of the nephropathy process. (
  • We reported that short-term hyperglycemia in healthy subjects leads, within a few hours, to both renal vasodilatation and an enhanced renal vasodilator response to captopril ( 3 ). (
  • Conclusion The increased flow velocity in the ophthalmic artery seems to be due to a vasodilator effect of sildenafil. (
  • Coronary artery bypass grafting (CABG) with extracorporeal circulation is a stressful procedure increasing sympathetic nervous system activity which could attenuate renal function due the interrelation of sympathetic nervous system, hemodynamics and renal function. (
  • It is also known that hemodynamics, sympathetic nervous system activity and renal function are tightly interrelated. (
  • Relevant studies include those implicating the renin-angiotensin-aldosterone system (RAAS), the sympathetic nervous system (SNS), and the role of renal prostaglandins (PGs). (
  • This chronic inflammatory demyelinating polyneuropathy, cold agglu-tinin disease, autoimmune hepatitis, and delayed breast development broad chest with and changes in hemodynamics that correspond to dates, one must understand the concept of immune cells present as septicemia without meningitis, meningococcemia with meningitis, or who have slow expiratory airflow so that they neglect their own use. (
  • The general focus of the Harris laboratory involves studies of regulation of renal epithelial cell growth and function during normal physiologic responses and after acute or chronic injury. (
  • Associations were examined in both the muscular peripheral arteries and the more elastic central arteries. (
  • This accounts for 60-97% of renal arterial lesions, which could lead to the occlusion of the renal artery and ischemic atrophy of the kidneys. (
  • The extracortical flow presumably represents medullary circulation with a mean transit time of 19 to 25 sec. (
  • Beach RE, Watts BA 3rd, Good DW et al (1991) Effects of graded oxygen tension on adenosine release by renal medullary and thick ascending limb suspensions. (
  • ΔGFR correlated inversely with basal STK-GFR, renal release of infilammatory markers, and medullary R2 * response to furosemide, but directly with GFR response to acetylcholine. (
  • Our model may be suitable for investigating disturbances of renal medullary circulation in human subjects. (
  • This study aimed to evaluate the effects of parecoxib on renal function by measuring plasma NGAL levels in an induced-ischemia model in rats and histologically evaluate possible lesions. (
  • 5 AMI caused by coronary artery dissection may be the first manifestation of FMD and the angiographic appearance of these lesions may represent SCAD or mimic typical atherosclerosis. (
  • Although the experimental evidence supports a role for O 2 − in the regulation of renal function, little is known about the renal effects of NADPH oxidase inhibitors or O 2 − scavengers in vivo. (
  • An area of continuing interest in the laboratory is regulation of renal epithelial cell function by eicosanoids. (
  • Left brachial artery adventitial diameter was determined during diastole by electronic caliper measurement of the adventitial to adventitial diameter. (
  • Inhaled sevoflurane during coronary artery bypass grafting (CABG) reduces postoperative Troponin levels and may be associated with improved outcome. (
  • Sevoflurane, an inhaled anesthetic is currently recommended for anesthesia during coronary artery bypass grafting (CABG). (
  • The angiotensin receptor antagonist valsartan, tempol, or apocynin blunted the angiotensin effects on renal excretion and NO, suggesting that angiotensin receptors stimulation induces the NADPH oxidase-dependent O 2 − generation that might reduce NO bioavailability. (
  • Invasive coronary angiography remains the gold standard imaging method for identifying coronary artery manifestations of FMD or SCAD (Figure 2). (
  • Alternative coronary artery imaging modalities such as intravascular ultrasound (IVUS), optical coherence tomography (OCT) and computed tomography (CT) angiography have been described, but their role in routine clinical care is less well defined. (
  • demonstrated resolution of coronary artery dissection on repeat angiography (34 to 795 days later) in 10 subjects with AMI and SCAD that did not show evidence of atherosclerosis. (
  • After three years of excessive confidence, overoptimistic expectations and performance of 15 to 20,000 renal denervation procedures in Europe, the failure of a single well-designed US trial-Symplicity HTN-3-to meet its primary efficacy endpoint has cast doubt on renal denervation as a whole. (
  • Accordingly, there is no doubt that renal denervation is not ready for clinical use. (
  • Spontaneous coronary artery dissection (SCAD) has emerged as an important etiology of acute coronary syndrome (ACS) in young otherwise healthy women who do not have risk factors for atherosclerosis. (
  • This experimental model suitably mimics the hemodynamics and the pathology of clinical pericardial tamponade situations, and on this basis, it provides an opportunity to study the adverse macro- and micro-circulatory effects and biochemical consequences of human cardiogenic shock. (
  • 5 Less common coronary artery manifestations of FMD include aneurysms, occlusions, long-smooth narrowing or distal tapering of the mid-distal coronary arteries, intramural hematoma, spasm, and tortuosity. (
  • After 8 weeks treatment from 16 weeks of age with 606A by a subcutaneously implanted osmotic pump, cardiac function, cardiac weight, acetylcholine-induced endothelium-dependent relaxation in the isolated aorta and renal function were estimated. (
  • Baseline renal vein and inferior vena cava levels of infilammatory markers were measured and their gradient and net release calculated. (
  • Parecoxib resulted in renal protection in this experimental model. (
  • Impairment of cardiac function and energetics in experimental renal failure. (
  • Conclusions: Low basal STK-GFR with preserved response to acetylcholine may predict benefit from revascularization in RAS, whereas renal infilammation and robust STK-R2 * responses to furosemide (possibly reflecting avid tubular oxygen consumption) are associated with less favorable outcomes. (
  • A common cause of ischemic renal disease is atherosclerosis. (
  • The extrinsic pathway are directly induced upon renal ischemic injury, while intrinsic pathways are dependent on mitochondrial signaling pathways. (