Hemodynamics
Vascular Resistance
Blood Flow Velocity
Cardiac Output
Models, Cardiovascular
Dogs
Hypertension, Pulmonary
Kidney
Pulsatile Flow
Glomerular Filtration Rate
Pulmonary Wedge Pressure
Splanchnic Circulation
Cardiography, Impedance
Pulmonary Artery
Oxygen
Oxygen Consumption
Ventricular Function, Left
Hypertension, Portal
Ultrasonography, Doppler, Transcranial
Spectroscopy, Near-Infrared
Arterial Pressure
Stroke Volume
Venous Pressure
Hypertension
Heart Failure
Diuresis
Hematocrit
Swine
Disease Models, Animal
Pulmonary Gas Exchange
Laser-Doppler Flowmetry
Rats, Sprague-Dawley
Renal Plasma Flow
Antihypertensive Agents
Cardiac Catheterization
Nitric Oxide
Renin
Anesthesia
Intracranial Aneurysm
Kidney Glomerulus
Catheterization, Swan-Ganz
Hemorheology
Ultrasonography, Doppler, Color
Sulfones
Ultrasonography, Doppler
Magnetic Resonance Angiography
Hydrodynamics
Acetazolamide
Middle Cerebral Artery
Heart Ventricles
Isoflurane
Carbon Dioxide
Myocardium
Treatment Outcome
Portal System
Shear Strength
Norepinephrine
Atrial Natriuretic Factor
Oxyhemoglobins
Vasodilation
Stress, Mechanical
Hypotension
Prospective Studies
Fontan Procedure
Hemodilution
Infusions, Intravenous
Epoprostenol
Ventricular Function, Right
Ventricular Pressure
Vascular Stiffness
Receptors, Endothelin
Echocardiography
Angiotensin II
Plasma Volume
Vasoconstriction
Carotid Artery, Internal
Isotonic Solutions
Hypotension, Controlled
Arterioles
Sus scrofa
Meclofenamic Acid
Lung
Purines
Hyperemia
Sheep
Cardiotonic Agents
Ophthalmic Artery
Computer Simulation
Milrinone
Pressure
Dose-Response Relationship, Drug
Endothelin-1
Central Venous Pressure
Echocardiography, Doppler
Medetomidine
Cyclic Nucleotide Phosphodiesterases, Type 5
Hypotension, Orthostatic
Angiotensin-Converting Enzyme Inhibitors
NG-Nitroarginine Methyl Ester
Sympathetic Nervous System
Chronic Disease
Blood Viscosity
Kidney Function Tests
Rats, Wistar
Nitric Oxide Synthase
Ultrasonography, Doppler, Pulsed
Analysis of Variance
Hypertrophy, Right Ventricular
Reference Values
Plasma Substitutes
Vena Cava, Inferior
Rats, Inbred SHR
Compliance
Hypertension, Renal
Random Allocation
Fentanyl
Heart Defects, Congenital
Femoral Vein
Cardiac Pacing, Artificial
Liver Cirrhosis
Sodium
Venous Insufficiency
Hemoglobins
Collateral Circulation
Models, Anatomic
Shock, Septic
Cardiovascular Physiological Phenomena
Cardiovascular System
Magnetic Resonance Imaging
Enalapril
Pulmonary Edema
Anesthesia, Intratracheal
Partial Pressure
Prostaglandins
Tetrazoles
Phenylpropionates
Aortic Valve Stenosis
Receptor, Endothelin A
Rheology
Ventricular Remodeling
Teprotide
Brain
Anesthesia, General
Angiotensin Receptor Antagonists
Heart-Assist Devices
Respiratory Physiological Processes
Phosphodiesterase Inhibitors
Aortic Valve
Lypressin
Natriuretic Agents
Double-Blind Method
Cardiopulmonary Bypass
Carotid Stenosis
Retinal Artery
Carotid Arteries
Hemofiltration
Imaging, Three-Dimensional
The evolution of early fibromuscular lesions hemodynamically induced in the dog renal artery. I. Light and transmission electron microscopy. (1/14436)
In view of the important roles of arterial intimal fibromuscular lesions as precursors of atherosclerotic plaque and occlusive lesions in arterial reconstructions, a model has been developed for the rapid hemodynamic induction of these lesions by anastomosis of the dog right renal artery to the inferior vena cava. Light and transmission electron microscopic observations were made on the arterial shunt after periods of rapid flow ranging form 10 minutes to 2 hours to identify initial factor(s) and evolutionary mechanisms in the etiology of the lesions. The sequence of events included aberrations in ruthenium red staining of the endothelial luminal membrane at 10 minutes, multilayered thickening of the subendothelial basement membrane (BM) at 15 minutes, and initial reorientation and migration of smooth muscle cells (SMC) into the intima along with the appearance of areas of degeneration of the internal elastic lamina (IEL) at 30 minutes. The endothelial cells were still intact in some areas overlying the SMC migration and IEL degeneration, but they were separating from the surface in other such areas. As subendothelium became exposed, some platelet adherence was noted. By 2 hours, the entire wall reaction was fully developed. Initial observations indicate that in the evolution of this hemodynamically induced lesion visible alteration in the endothelial cells is not prerequisite to degeneration of the underlying IEL and reorientation and migration of medial SMC. (+info)Signal-, set- and movement-related activity in the human brain: an event-related fMRI study. (2/14436)
Electrophysiological studies on monkeys have been able to distinguish sensory and motor signals close in time by pseudorandomly delaying the cue that instructs the movement from the stimulus that triggers the movement. We have used a similar experimental design in functional magnetic resonance imaging (fMRI), scanning subjects while they performed a visuomotor conditional task with instructed delays. One of four shapes was presented briefly. Two shapes instructed the subjects to flex the index finger; the other two shapes coded the flexion of the middle finger. The subjects were told to perform the movement after a tone. We have exploited a novel use of event-related fMRI. By systematically varying the interval between the visual and acoustic stimuli, it has been possible to estimate the significance of the evoked haemodynamic response (EHR) to each of the stimuli, despite their temporal proximity in relation to the time constant of the EHR. Furthermore, by varying the phase between events and image acquisition, we have been able to achieve high temporal resolution while scanning the whole brain. We dissociated sensory and motor components of the sensorimotor transformations elicited by the task, and assessed sustained activity during the instructed delays. In calcarine and occipitotemporal cortex, the responses were exclusively associated with the visual instruction cues. In temporal auditory cortex and in primary motor cortex, they were exclusively associated with the auditory trigger stimulus. In ventral prefrontal cortex there were movement-related responses preceded by preparatory activity and by signal-related activity. Finally, responses associated with the instruction cue and with sustained activity during the delay period were observed in the dorsal premotor cortex and in the dorsal posterior parietal cortex. Where the association between a visual cue and the appropriate movement is arbitrary, the underlying visuomotor transformations are not achieved exclusively through frontoparietal interactions. Rather, these processes seem to rely on the ventral visual stream, the ventral prefrontal cortex and the anterior part of the dorsal premotor cortex. (+info)Protective effect of bactericidal/permeability-increasing protein (rBPI21) in baboon sepsis is related to its antibacterial, not antiendotoxin, properties. (3/14436)
OBJECTIVE AND SUMMARY BACKGROUND DATA: The recombinant fragment of bactericidal/permeability-increasing protein, rBPI21, has potent bactericidal activity against gram-negative bacteria as well as antiendotoxin (lipopolysaccharide [LPS]) action. On the basis of these activities, the authors sought to discover whether rBPI21 would be protective in baboons with live Escherichia coli-induced sepsis and whether the potential protective effects of rBPI21 (together with antibiotics) would be more closely related to its antibacterial or LPS-neutralizing effects. METHODS: In a prospective, randomized, placebo-controlled subchronic laboratory study, the efficacy of rBPI21 or placebo was studied over 72 hours in chronically instrumented male baboons infused with live E. coli under antibiotic therapy. RESULTS: Intravenous rBPI21 attenuated sepsis-related organ failure and increased survival significantly. Bacteremia was significantly reduced in the rBPI21 group at 2 hours after the start of the E. coli infusion, whereas circulating LPS was less affected. The in vivo formation of tumor necrosis factor was significantly suppressed by the rBPI21 treatment regimen. Microcirculation and organ function were improved. CONCLUSIONS: In baboon live E. coli sepsis, the salutary effect of rBPI21 results from a more prevalent antibacterial than antiendotoxin activity. (+info)NaCl-induced renal vasoconstriction in salt-sensitive African Americans: antipressor and hemodynamic effects of potassium bicarbonate. (4/14436)
In 16 African Americans (blacks, 14 men, 2 women) with average admission mean arterial pressure (MAP, mm Hg) 99.9+/-3.5 (mean+/-SEM), we investigated whether NaCl-induced renal vasoconstriction attends salt sensitivity and, if so, whether supplemental KHCO3 ameliorates both conditions. Throughout a 3-week period under controlled metabolic conditions, all subjects ate diets containing 15 mmol NaCl and 30 mmol potassium (K+) (per 70 kg body wt [BW] per day). Throughout weeks 2 and 3, NaCl was loaded to 250 mmol/d; throughout week 3, dietary K+ was supplemented to 170 mmol/d (KHCO3). On the last day of each study week, we measured renal blood flow (RBF) and glomerular filtration rate (GFR) using renal clearances of PAH and inulin. Ten subjects were salt sensitive (SS) (DeltaMAP >+5%) and 6 salt resistant (SR). In NaCl-loaded SS but not SR subjects, RBF (mL/min/1.73 m2) decreased from 920+/-75 to 828+/-46 (P<0.05); filtration fraction (FF, %) increased from 19. 4+/- to 21.4 (P<0.001); and renal vascular resistance (RVR) (10(3)xmm Hg/[mL/min]) increased from 101+/-8 to 131+/-10 (P<0.001). In all subjects combined, DeltaMAP varied inversely with DeltaRBF (r =-0.57, P=0.02) and directly with DeltaRVR (r = 0.65, P=0.006) and DeltaFF (r = 0.59, P=0.03), but not with MAP before NaCl loading. When supplemental KHCO3 abolished the pressor effect of NaCl in SS subjects, RBF was unaffected but GFR and FF decreased. The results show that in marginally K+-deficient blacks (1) NaCl-induced renal vasoconstrictive dysfunction attends salt sensitivity; (2) the dysfunction varies in extent directly with the NaCl-induced increase in blood pressure (BP); and (3) is complexly affected by supplemented KHCO3, GFR and FF decreasing but RBF not changing. In blacks, NaCl-induced renal vasoconstriction may be a pathogenetic event in salt sensitivity. (+info)Low calorie diet enhances renal, hemodynamic, and humoral effects of exogenous atrial natriuretic peptide in obese hypertensives. (5/14436)
The expression of the natriuretic peptide clearance receptor is abundant in human and rat adipose tissue, where it is specifically inhibited by fasting. In obese hypertensives, plasma atrial natriuretic peptide (ANP) levels were found to be lower than in obese normotensives. Therefore, the increased adipose mass might influence ANP levels and/or its biological activity. The aim of the present study was to evaluate whether the humoral, hemodynamic, and renal effects of exogenous ANP in obese hypertensives might be enhanced by a very low calorie diet. Eight obese hypertensives received a bolus injection of ANP (0.6 mg/kg) after 2 weeks of a normal calorie/normal sodium diet, and blood pressure (BP), heart rate, ANP, cGMP, plasma renin activity, and aldosterone were evaluated for 2 hours before and after the injection. Diuresis and natriuresis were measured every 30 minutes. The patients then started a low calorie/normal sodium diet (510 kcal/150 mmol/d) for 4 days, and then the ANP injection protocol was repeated. The low calorie diet induced a slight weight loss (from 90.6+/-1.1 to 87. 7+/-1.2 kg; P<0.01), which was accompanied by increase of cGMP excretion (from 146.0+/-10.1 to 154.5+/-9.5 nmol/24 h; P<0.05) together with a reduction of BP (P<0.01 versus basal levels). ANP injection after diet was followed by an increase of ANP levels similar to that observed before diet, but plasma cGMP, diuresis, and natriuresis increased significantly only after diet. Similarly, the decrease of BP after ANP administration was significantly higher after diet (change in mean arterial pressure, -6.4+/-0.7 versus -4. 0+/-0.6 mm Hg; P<0.05) as well as that of aldosterone (P<0.01). These data show that a low calorie diet enhances the humoral, renal, and hemodynamic effects of ANP in obese hypertensives and confirm the importance of caloric intake in modulating the biological activity of ANP, suggesting that the natriuretic peptide system can play a role in the acute changes of natriuresis and diuresis associated with caloric restriction. (+info)Sympathetic nerve alterations assessed with 123I-MIBG in the failing human heart. (6/14436)
Norepinephrine (NE) reuptake function is impaired in heart failure and this may participate in myocyte hyperstimulation by the neurotransmitter. This alteration can be assessed by 123I-metaiodobenzylguanidine (MIBG) scintigraphy. METHODS: To determine whether the impairment of neuronal NE reuptake was reversible after metoprolol therapy, we studied 18 patients (43+/-7 y) with idiopathic dilated cardiomyopathy who were stabilized at least for 3 mo with captopril and diuretics. Patients underwent, before and after 6 mo of therapy with metoprolol, measurements of radionuclide left ventricular ejection fraction (LVEF), maximal oxygen consumption and plasma NE concentration. The cardiac adrenergic innervation function was scintigraphically assessed with MIBG uptake and release measurements on the planar images obtained 20 min and 4 h after tracer injection. To evaluate whether metoprolol had a direct interaction with cardiac MIBG uptake and release, six normal subjects were studied before and after a 1-mo metoprolol intake. RESULTS: In controls, neither cardiac MIBG uptake and release nor circulating NE concentration changed after the 1-mo metoprolol intake. Conversely, after a 6-mo therapy with metoprolol, patients showed increased cardiac MIBG uptake (129%+/-10% versus 138%+/-17%; P = 0.009), unchanged cardiac MIBG release and decreased plasma NE concentration (0.930+/-412 versus 0.721+/-0.370 ng/mL; P = 0.02). In parallel, patients showed improved New York Heart Association class (2.44+/-0.51 versus 2.05+/-0.23; P = 0.004) and increased LVEF (20%+/-8% versus 27%+/-8%; P = 0.0005), whereas maximal oxygen uptake remained unchanged. CONCLUSION: Thus, a parallel improvement of myocardial NE reuptake and of hemodynamics was observed after a 6-mo metoprolol therapy, suggesting that such agents may be beneficial in heart failure by directly protecting the myocardium against excessive NE stimulation. (+info)Enteroviral RNA replication in the myocardium of patients with left ventricular dysfunction and clinically suspected myocarditis. (7/14436)
BACKGROUND: Previous studies dealing with the detection of enteroviral RNA in human endomyocardial biopsies have not differentiated between latent persistence of the enteroviral genome and active viral replication. Enteroviruses that are considered important factors for the development of myocarditis have a single-strand RNA genome of positive polarity that is transcribed by a virus-encoded RNA polymerase into a minus-strand mRNA during active viral replication. The synthesis of multiple copies of minus-strand enteroviral RNA therefore occurs only at sites of active viral replication but not in tissues with mere persistence of the viral genome. METHODS AND RESULTS: We investigated enteroviral RNA replication versus enteroviral RNA persistence in endomyocardial biopsies of 45 patients with left ventricular dysfunction and clinically suspected myocarditis. Using reverse-transcriptase polymerase chain reaction in conjunction with Southern blot hybridization, we established a highly sensitive assay to specifically detect plus-strand versus minus-strand enteroviral RNA in the biopsies. Plus-strand enteroviral RNA was detected in endomyocardial biopsies of 18 (40%) of 45 patients, whereas minus-strand RNA as an indication of active enteroviral RNA replication was detected in only 10 (56%) of these 18 plus-strand-positive patients. Enteroviral RNA was not found in biopsies of the control group (n=26). CONCLUSIONS: These data demonstrate that a significant fraction of patients with left ventricular dysfunction and clinically suspected myocarditis had active enteroviral RNA replication in their myocardium (22%). Differentiation between patients with active viral replication and latent viral persistence should be particularly important in future studies evaluating different therapeutic strategies. In addition, molecular genetic detection of enteroviral genome and differentiation between replicating versus persistent viruses is possible in a single endomyocardial biopsy. (+info)Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast. (8/14436)
BACKGROUND: Inflammatory and immunological responses of vascular cells have been shown to play a significant role in the progression of atheromatous formation. Tranilast [N-(3,4-dimethoxycinnamoyl) anthranillic acid] inhibits release of cytokines and chemical mediators from various cells, including macrophages, leading to suppression of inflammatory and immunological responses. This study tested whether tranilast may suppress atheromatous formation in Watanabe heritable hyperlipidemic (WHHL) rabbits. METHODS AND RESULTS: WHHL rabbits (2 months old) were given either 300 mg x kg-1 x d-1 of tranilast (Tranilast, n=12) or vehicle (Control, n=13) PO for 6 months. Tranilast treatment was found to suppress the aortic area covered with plaque. Immunohistochemical analysis showed that there was no difference in the percentage of the RAM11-positive macrophage area and the frequency of CD5-positive cells (T cells) in intimal plaques between Tranilast and Control. Major histocompatibility complex (MHC) class II expression in macrophages and interleukin-2 (IL-2) receptor expression in T cells, as markers of the immunological activation in these cells, was suppressed in atheromatous plaque by tranilast treatment. Flow cytometry analysis of isolated human and rabbit peripheral blood mononuclear cells showed that an increase in expression both of MHC class II antigen on monocytes by incubation with interferon-gamma and of IL-2 receptor on T cells by IL-2 was suppressed by the combined incubation with tranilast. CONCLUSIONS: The results indicate that tranilast suppresses atherosclerotic development partly through direct inhibition of immunological activation of monocytes/macrophages and T cells in the atheromatous plaque. (+info)Blood pressure is the force exerted by the blood against the walls of the blood vessels as the heart pumps blood through the body. It is measured in millimeters of mercury (mmHg) and is typically expressed as two numbers: systolic pressure (the pressure when the heart beats) and diastolic pressure (the pressure when the heart is at rest between beats). Normal blood pressure is considered to be below 120/80 mmHg, while high blood pressure (hypertension) is defined as a systolic pressure of 140 mmHg or higher and/or a diastolic pressure of 90 mmHg or higher. High blood pressure is a major risk factor for heart disease, stroke, and other health problems.
Blood flow velocity refers to the speed at which blood flows through a blood vessel or artery. It is typically measured in units of meters per second (m/s) or centimeters per second (cm/s). Blood flow velocity is an important parameter in the assessment of cardiovascular health, as it can provide information about the functioning of the heart, blood vessels, and blood circulation. Blood flow velocity can be measured using various techniques, including Doppler ultrasound, magnetic resonance imaging (MRI), and computed tomography (CT) angiography. These techniques use sound waves or electromagnetic signals to detect the movement of blood through the blood vessels and calculate the velocity of blood flow. Abnormal blood flow velocities can indicate a variety of cardiovascular conditions, such as stenosis (narrowing) of the blood vessels, atherosclerosis (hardening of the arteries), and blood clots. Therefore, measuring blood flow velocity is an important diagnostic tool in the evaluation and management of cardiovascular diseases.
Cardiac output (CO) is a measure of the amount of blood that is pumped by the heart per minute. It is calculated by multiplying the heart rate (the number of times the heart beats per minute) by the stroke volume (the amount of blood pumped by each beat of the heart). Cardiac output is an important indicator of the body's ability to deliver oxygen and nutrients to the tissues and remove waste products. It is influenced by a number of factors, including the strength of the heart's contractions, the resistance of the blood vessels, and the volume of blood in the circulation. In the medical field, cardiac output is often measured using techniques such as echocardiography, thermodilution, or dye dilution. Abnormalities in cardiac output can be associated with a variety of medical conditions, including heart failure, anemia, and shock.
Cerebrovascular circulation refers to the blood flow to and from the brain and spinal cord. It is responsible for delivering oxygen and nutrients to the brain and removing waste products. The brain is a highly metabolically active organ, and it requires a constant supply of oxygen and nutrients to function properly. The cerebrovascular system is made up of the arteries, veins, and capillaries that supply blood to the brain. Any disruption in the cerebrovascular circulation can lead to serious health problems, including stroke and brain injury.
Hypertension, Pulmonary refers to high blood pressure that affects the blood vessels in the lungs. It is also known as Pulmonary Arterial Hypertension (PAH) or Pulmonary Hypertension (PH). PAH is a rare and serious condition that causes the blood vessels in the lungs to narrow and stiffen, leading to increased blood pressure in the pulmonary arteries. This increased pressure can cause the heart to work harder to pump blood through the lungs, which can lead to heart failure over time. Symptoms of Pulmonary Hypertension may include shortness of breath, fatigue, chest pain, dizziness, and fainting. The condition can be caused by a variety of factors, including genetic mutations, infections, autoimmune disorders, and exposure to certain toxins. Treatment for Pulmonary Hypertension typically involves medications to lower blood pressure and improve blood flow in the lungs, as well as oxygen therapy and in some cases, surgery. Early diagnosis and treatment are important for improving outcomes and reducing the risk of complications.
Blood volume refers to the total amount of blood present in the circulatory system of an individual. It is an important parameter in the medical field as it helps to regulate blood pressure, maintain fluid balance, and transport oxygen and nutrients to the body's tissues. The normal blood volume for an adult male is approximately 5 liters, while for an adult female, it is around 4.5 liters. Blood volume can be affected by a variety of factors, including dehydration, blood loss, fluid retention, and certain medical conditions such as heart failure or kidney disease. Measuring blood volume is typically done through a blood test called a hematocrit, which measures the percentage of red blood cells in the blood. Other methods of measuring blood volume include ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI).
The coronary circulation refers to the blood flow that supplies oxygen and nutrients to the heart muscle. It is a specialized network of blood vessels that branches off from the aorta, the main artery that carries oxygenated blood from the heart to the rest of the body. The coronary circulation is divided into two main branches: the left coronary artery and the right coronary artery. The left coronary artery supplies blood to the left side of the heart, including the left atrium, left ventricle, and the coronary arteries that branch off from it. The right coronary artery supplies blood to the right atrium and the right ventricle, as well as the coronary arteries that branch off from it. The coronary circulation is essential for maintaining the health and function of the heart muscle. If the blood flow to the heart is restricted or blocked, it can lead to a heart attack, which can be life-threatening. Therefore, the coronary circulation is closely monitored by healthcare professionals, and treatments such as angioplasty or bypass surgery may be necessary to restore blood flow to the heart.
Cardiography, Impedance is a medical imaging technique that uses electrical signals to create images of the heart. It is also known as impedance cardiography or bioimpedance cardiography. During an impedance cardiography test, electrodes are placed on the skin of the chest, arms, and legs. These electrodes send electrical signals through the body, which are then measured to determine the electrical impedance of the heart. The impedance of the heart changes as it contracts and relaxes, allowing the test to measure the volume of blood being pumped by the heart. The results of an impedance cardiography test can be used to diagnose a variety of heart conditions, including heart failure, valvular heart disease, and coronary artery disease. It can also be used to monitor the effectiveness of treatments for these conditions and to assess the overall function of the heart.
In the medical field, oxygen is a gas that is essential for the survival of most living organisms. It is used to treat a variety of medical conditions, including respiratory disorders, heart disease, and anemia. Oxygen is typically administered through a mask, nasal cannula, or oxygen tank, and is used to increase the amount of oxygen in the bloodstream. This can help to improve oxygenation of the body's tissues and organs, which is important for maintaining normal bodily functions. In medical settings, oxygen is often used to treat patients who are experiencing difficulty breathing due to conditions such as pneumonia, chronic obstructive pulmonary disease (COPD), or asthma. It may also be used to treat patients who have suffered from a heart attack or stroke, as well as those who are recovering from surgery or other medical procedures. Overall, oxygen is a critical component of modern medical treatment, and is used in a wide range of clinical settings to help patients recover from illness and maintain their health.
Hypertension, Portal refers to high blood pressure in the portal vein, which is the main vein that carries blood from the digestive organs to the liver. This condition is also known as portal hypertension and is typically associated with liver disease, such as cirrhosis or liver fibrosis. Portal hypertension can cause a number of complications, including varices (enlarged veins), ascites (fluid accumulation in the abdomen), and portal vein thrombosis (blood clot in the portal vein). Treatment for portal hypertension may include medications to reduce blood pressure, lifestyle changes, and in some cases, surgery.
Blood gas analysis is a medical test that measures the levels of gases, such as oxygen and carbon dioxide, in the blood. It is typically performed by drawing a small sample of blood from a vein in the arm and analyzing it using a machine called a blood gas analyzer. The results of a blood gas analysis can provide important information about a person's respiratory and circulatory function, as well as their acid-base balance. This information can be useful in diagnosing and treating a variety of medical conditions, including respiratory disorders, heart problems, and metabolic imbalances. Blood gas analysis is often used to monitor patients who are critically ill or who are undergoing certain medical procedures, such as surgery or mechanical ventilation. It can also be used to guide treatment decisions in conditions such as asthma, chronic obstructive pulmonary disease (COPD), and pneumonia.
Arterial pressure, also known as systolic and diastolic pressure, is a measure of the force exerted by blood against the walls of arteries as it flows through the circulatory system. It is typically measured using a device called a sphygmomanometer and a stethoscope. Systolic pressure is the higher number and represents the pressure in the arteries when the heart is contracting and pumping blood out to the body. Diastolic pressure is the lower number and represents the pressure in the arteries when the heart is at rest between beats. Arterial pressure is an important indicator of cardiovascular health and is used to diagnose and monitor conditions such as hypertension (high blood pressure), hypotension (low blood pressure), and cardiovascular disease.
In the medical field, arteries are blood vessels that carry oxygenated blood away from the heart to the rest of the body. They are typically thick-walled and muscular, and their walls are lined with smooth muscle and elastic tissue that helps to maintain their shape and elasticity. There are three main types of arteries: 1. Ascending aorta: This is the largest artery in the body, and it carries oxygenated blood from the heart to the rest of the body. 2. Descending aorta: This artery carries oxygenated blood from the ascending aorta to the abdomen and lower extremities. 3. Coronary arteries: These arteries supply oxygenated blood to the heart muscle. Arteries are an essential part of the circulatory system, and any damage or blockage to them can lead to serious health problems, including heart attack and stroke.
Hypertension, also known as high blood pressure, is a medical condition in which the force of blood against the walls of the arteries is consistently too high. This can lead to damage to the blood vessels, heart, and other organs over time, and can increase the risk of heart disease, stroke, and other health problems. Hypertension is typically defined as having a systolic blood pressure (the top number) of 140 mmHg or higher, or a diastolic blood pressure (the bottom number) of 90 mmHg or higher. However, some people may be considered hypertensive if their blood pressure is consistently higher than 120/80 mmHg. Hypertension can be caused by a variety of factors, including genetics, lifestyle choices (such as a diet high in salt and saturated fat, lack of physical activity, and smoking), and certain medical conditions (such as kidney disease, diabetes, and sleep apnea). It is often a chronic condition that requires ongoing management through lifestyle changes, medication, and regular monitoring of blood pressure levels.
Heart failure, also known as congestive heart failure, is a medical condition in which the heart is unable to pump enough blood to meet the body's needs. This can lead to a buildup of fluid in the lungs, liver, and other organs, causing symptoms such as shortness of breath, fatigue, and swelling in the legs and ankles. Heart failure can be caused by a variety of factors, including damage to the heart muscle from a heart attack, high blood pressure, or long-term damage from conditions such as diabetes or coronary artery disease. It can also be caused by certain genetic disorders or infections. Treatment for heart failure typically involves medications to improve heart function and reduce fluid buildup, as well as lifestyle changes such as a healthy diet, regular exercise, and avoiding smoking and excessive alcohol consumption. In some cases, surgery or other medical procedures may be necessary to treat the underlying cause of the heart failure or to improve heart function.
Blood circulation is the movement of blood through the circulatory system of the body. It is the process by which blood is pumped from the heart to the body's tissues and organs, where it delivers oxygen and nutrients, and removes waste products. The circulatory system includes the heart, blood vessels (arteries, veins, and capillaries), and blood. The heart is the central pump that propels blood through the circulatory system. It contracts and relaxes in a rhythmic pattern to push blood out of the heart and into the arteries. The arteries carry oxygen-rich blood away from the heart to the body's tissues and organs. The veins carry oxygen-poor blood back to the heart. Capillaries are tiny blood vessels that connect arteries and veins and allow for the exchange of oxygen, nutrients, and waste products between the blood and the body's tissues. Blood circulation is essential for maintaining the health and function of the body's tissues and organs. It helps regulate body temperature, transport hormones and other signaling molecules, and defend against infection and disease. Any disruption to blood circulation can have serious consequences, including tissue damage, organ failure, and even death.
In the medical field, "Disease Models, Animal" refers to the use of animals to study and understand human diseases. These models are created by introducing a disease or condition into an animal, either naturally or through experimental manipulation, in order to study its progression, symptoms, and potential treatments. Animal models are used in medical research because they allow scientists to study diseases in a controlled environment and to test potential treatments before they are tested in humans. They can also provide insights into the underlying mechanisms of a disease and help to identify new therapeutic targets. There are many different types of animal models used in medical research, including mice, rats, rabbits, dogs, and monkeys. Each type of animal has its own advantages and disadvantages, and the choice of model depends on the specific disease being studied and the research question being addressed.
Antihypertensive agents, also known as antihypertensives, are medications that are used to lower blood pressure. High blood pressure, or hypertension, is a common condition that can increase the risk of heart disease, stroke, and other health problems. Antihypertensive agents work by relaxing blood vessels, reducing the workload on the heart, and decreasing the amount of blood that the heart has to pump to maintain adequate blood flow to the body. There are several different types of antihypertensive agents, including diuretics, beta blockers, calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs). Each type of antihypertensive agent works through a different mechanism to lower blood pressure, and the choice of medication will depend on the individual patient's specific needs and medical history. Antihypertensive agents are typically prescribed by a healthcare provider and are taken orally, usually once or twice a day. It is important to follow the prescribed dosage and to take the medication at the same time each day to ensure consistent blood pressure control. In some cases, a combination of different antihypertensive agents may be used to achieve the desired blood pressure level.
Cardiac catheterization is a medical procedure that involves inserting a thin, flexible tube called a catheter into a blood vessel in the groin, arm, or neck and threading it up to the heart. The catheter is then used to inject a contrast dye into the heart's chambers and blood vessels, which allows doctors to see the heart's structure and function on X-ray images. The procedure is typically used to diagnose and treat a variety of heart conditions, including coronary artery disease, heart valve problems, and heart rhythm disorders. During the procedure, doctors may also perform additional tests, such as angiography, which involves taking X-ray images of the blood vessels to look for blockages or narrowing. Cardiac catheterization is generally considered a safe and minimally invasive procedure, with a low risk of complications. However, as with any medical procedure, there are some risks, including bleeding, infection, and damage to the blood vessels or heart.
Nitric oxide (NO) is a colorless, odorless gas that is produced naturally in the body by various cells, including endothelial cells in the lining of blood vessels. It plays a crucial role in the regulation of blood flow and blood pressure, as well as in the immune response and neurotransmission. In the medical field, NO is often studied in relation to cardiovascular disease, as it is involved in the regulation of blood vessel dilation and constriction. It has also been implicated in the pathogenesis of various conditions, including hypertension, atherosclerosis, and heart failure. NO is also used in medical treatments, such as in the treatment of erectile dysfunction, where it is used to enhance blood flow to the penis. It is also used in the treatment of pulmonary hypertension, where it helps to relax blood vessels in the lungs and improve blood flow. Overall, NO is a critical molecule in the body that plays a vital role in many physiological processes, and its study and manipulation have important implications for the treatment of various medical conditions.
Renin is an enzyme produced by specialized cells in the kidneys called juxtaglomerular cells. It plays a crucial role in the regulation of blood pressure and fluid balance in the body. Renin is released in response to low blood pressure or low blood volume, which triggers a series of reactions that ultimately lead to the production of angiotensin II, a potent vasoconstrictor that helps to raise blood pressure. Renin also stimulates the production of aldosterone, a hormone that helps to regulate the balance of sodium and potassium in the body and maintain fluid balance. Abnormal levels of renin can lead to various medical conditions, including hypertension (high blood pressure), kidney disease, and primary aldosteronism. Renin is typically measured in the blood as part of a comprehensive evaluation of blood pressure and kidney function.
Anesthesia is a medical procedure that involves the use of drugs or other techniques to induce a state of unconsciousness or a loss of sensation or awareness during a surgical, diagnostic, or therapeutic procedure. The goal of anesthesia is to provide pain relief and to allow medical professionals to perform procedures without the patient experiencing discomfort or distress. There are several types of anesthesia, including general anesthesia, regional anesthesia, and local anesthesia. General anesthesia involves the use of drugs to induce a state of unconsciousness and to relax all the muscles in the body. Regional anesthesia involves the use of drugs to numb a specific area of the body, such as the lower half of the body for a Cesarean section or the arm for a shoulder replacement surgery. Local anesthesia involves the use of drugs to numb a small area of the body, such as the skin for a minor procedure like a vaccination or a biopsy. Anesthesia is typically administered by an anesthesiologist, who is a medical doctor specializing in the field of anesthesia. The anesthesiologist works closely with the surgeon or other medical professionals to ensure that the patient receives the appropriate level of anesthesia for the procedure being performed.
An intracranial aneurysm is a bulge or balloon-like dilation of a blood vessel in the brain. It occurs when a weakened area in the wall of the blood vessel balloons out and forms a sac. This can cause the blood vessel to become stretched and prone to rupture, which can lead to a life-threatening brain hemorrhage. Intracranial aneurysms are most commonly found in the arteries that supply blood to the brain, particularly the anterior communicating artery, the middle cerebral artery, and the internal carotid artery. They can occur at any age, but are more common in people over the age of 50. Risk factors for developing an intracranial aneurysm include smoking, high blood pressure, a family history of the condition, and certain genetic disorders. Treatment options for intracranial aneurysms include surgery to clip or coagulate the aneurysm, or endovascular coiling, which involves inserting a catheter through a blood vessel in the groin and threading it up to the aneurysm, where a coil is placed to fill the aneurysm and prevent it from rupturing.
Catheterization, Swan-Ganz is a medical procedure used to measure the pressures and flows of blood in the heart and lungs. It involves inserting a thin, flexible tube called a catheter into a blood vessel in the groin and threading it up to the heart and lungs. The catheter is equipped with sensors that measure the pressures and flows of blood, providing valuable information to doctors about the functioning of the heart and lungs. This procedure is often used to diagnose and treat heart and lung conditions, such as heart failure, pneumonia, and pulmonary embolism. It is named after Dr. Paul Swan and Dr. Walther Ganz, who developed the technique in the 1950s.
Cerebral arteries are blood vessels that supply oxygenated blood to the brain. There are two main types of cerebral arteries: the internal carotid arteries and the vertebral arteries. These arteries branch off from the aorta and travel up through the neck and into the brain, where they give rise to smaller arteries and arterioles that supply blood to different regions of the brain. The internal carotid arteries are located on either side of the neck and supply blood to the front and sides of the brain. The vertebral arteries are located in the vertebral canal and supply blood to the back and base of the brain. Cerebral arteries are critical for maintaining proper brain function, as the brain requires a constant supply of oxygen and nutrients to function properly. Damage or blockage of cerebral arteries can lead to a variety of neurological problems, including stroke, headache, and cognitive impairment.
Sulfones are a class of organic compounds that contain a sulfur-oxygen double bond. They are often used as intermediates in the synthesis of other organic compounds, and they have a variety of applications in the medical field. One important use of sulfones in medicine is as anti-inflammatory agents. Sulfones such as sulfasalazine and mesalamine are used to treat inflammatory bowel diseases like ulcerative colitis and Crohn's disease. These drugs work by inhibiting the production of inflammatory chemicals in the body. Sulfones are also used as anticonvulsants, which are drugs that help prevent seizures. One example of a sulfone anticonvulsant is ethosuximide, which is used to treat epilepsy. In addition, sulfones have been studied for their potential use in treating cancer. Some sulfones have been shown to have anti-tumor activity, and they are being investigated as potential treatments for a variety of different types of cancer. Overall, sulfones have a variety of potential applications in the medical field, and they continue to be an active area of research and development.
Hemorrhagic shock is a medical emergency that occurs when a person loses a significant amount of blood, leading to a drop in blood pressure and inadequate blood flow to vital organs. This can result in damage to organs, tissue, and cells, and if not treated promptly, can be life-threatening. Hemorrhagic shock can be caused by a variety of factors, including trauma (such as a severe injury or surgery), childbirth, severe bleeding from a medical condition (such as a bleeding ulcer or a bleeding tumor), or a severe allergic reaction. Symptoms of hemorrhagic shock may include pale skin, rapid heartbeat, rapid breathing, dizziness or lightheadedness, cold, clammy skin, and a weak or rapid pulse. Treatment typically involves stabilizing the patient's blood pressure and stopping the bleeding, which may involve surgery, medications, or other interventions.
Acetazolamide is a medication that is used to treat a variety of medical conditions, including: 1. High altitude sickness: Acetazolamide is used to prevent and treat altitude sickness, which occurs when a person is exposed to high altitudes and experiences symptoms such as headache, nausea, and dizziness. 2. Glaucoma: Acetazolamide is used to lower the pressure inside the eye in people with glaucoma, a condition in which the pressure inside the eye is too high and can damage the optic nerve. 3. Epilepsy: Acetazolamide is sometimes used as an adjunctive therapy to treat certain types of epilepsy, such as Lennox-Gastaut syndrome. 4. Fluid retention: Acetazolamide is used to treat fluid retention, which can occur in people with heart failure, kidney disease, or other conditions. 5. Acute mountain sickness: Acetazolamide is used to treat acute mountain sickness, which is a condition that occurs when a person is exposed to high altitudes and experiences symptoms such as headache, nausea, and dizziness. Acetazolamide is usually taken by mouth, although it can also be given intravenously in some cases. It works by decreasing the amount of bicarbonate ions in the body, which helps to lower the pressure inside the eye and reduce fluid retention.
Isoflurane is a volatile anesthetic gas that is commonly used in medical procedures to induce and maintain general anesthesia. It is a colorless, odorless gas that is similar in structure to halothane, another anesthetic gas. When inhaled, isoflurane produces a state of unconsciousness and a lack of response to pain, allowing medical procedures to be performed without the patient feeling any discomfort. It also has a relatively low risk of causing side effects, such as nausea, vomiting, or respiratory depression. Isoflurane is often used in combination with other anesthetics, such as opioids or muscle relaxants, to provide a more complete anesthetic effect. It is also used in veterinary medicine and in research settings to induce anesthesia in animals.
In the medical field, carbon dioxide (CO2) is a gas that is produced as a byproduct of cellular respiration and is exhaled by the body. It is also used in medical applications such as carbon dioxide insufflation during colonoscopy and laparoscopic surgery, and as a component of medical gases used in anesthesia and respiratory therapy. High levels of CO2 in the blood (hypercapnia) can be a sign of respiratory or metabolic disorders, while low levels (hypocapnia) can be caused by respiratory failure or metabolic alkalosis.
Norepinephrine, also known as noradrenaline, is a neurotransmitter and hormone that plays a crucial role in the body's "fight or flight" response. It is produced by the adrenal glands and is also found in certain neurons in the brain and spinal cord. In the medical field, norepinephrine is often used as a medication to treat low blood pressure, shock, and heart failure. It works by constricting blood vessels and increasing heart rate, which helps to raise blood pressure and improve blood flow to vital organs. Norepinephrine is also used to treat certain types of depression, as it can help to increase feelings of alertness and energy. However, it is important to note that norepinephrine can have side effects, including rapid heartbeat, high blood pressure, and anxiety, and should only be used under the supervision of a healthcare professional.
Atrial Natriuretic Factor (ANF) is a hormone that is produced by the heart's atria in response to increased pressure within the atria. ANF is released into the bloodstream and acts as a natural diuretic, helping to regulate blood pressure and fluid balance in the body. ANF works by relaxing blood vessels, which reduces blood pressure and allows the kidneys to excrete more sodium and water. This helps to reduce the volume of fluid in the body and lower blood pressure. ANF also inhibits the release of aldosterone, a hormone that regulates the balance of sodium and potassium in the body. In addition to its role in regulating blood pressure and fluid balance, ANF has been shown to have other effects on the body, including reducing the workload on the heart and improving heart function. ANF is also involved in the regulation of the renin-angiotensin-aldosterone system, which plays a key role in blood pressure regulation. Abnormal levels of ANF can be associated with a variety of medical conditions, including heart failure, hypertension, and kidney disease.
Oxyhemoglobins are a type of hemoglobin molecule that is carrying oxygen. Hemoglobin is a protein found in red blood cells that is responsible for transporting oxygen from the lungs to the body's tissues and carbon dioxide from the tissues back to the lungs. When hemoglobin binds to oxygen, it forms oxyhemoglobin. This process is known as oxygenation. Oxyhemoglobin is the form of hemoglobin that is most commonly found in the blood and is essential for the proper functioning of the body's cells.
Hypotension is a medical condition characterized by low blood pressure. Blood pressure is the force exerted by the blood against the walls of the arteries as the heart pumps blood. It is measured in millimeters of mercury (mmHg) and is typically expressed as two numbers, systolic pressure (the pressure when the heart beats) and diastolic pressure (the pressure when the heart is at rest between beats). Hypotension is defined as a systolic blood pressure below 90 mmHg or a diastolic blood pressure below 60 mmHg. In some cases, a lower blood pressure may be considered normal or even desirable, depending on the individual's age, health status, and other factors. Hypotension can be caused by a variety of factors, including dehydration, medication side effects, heart problems, blood loss, and certain medical conditions such as diabetes, kidney disease, and hormonal imbalances. Symptoms of hypotension may include dizziness, lightheadedness, fainting, and fatigue. Treatment for hypotension depends on the underlying cause and may include medications, lifestyle changes, or medical procedures.
Epoprostenol is a medication that is used to treat a variety of medical conditions, including pulmonary hypertension (high blood pressure in the lungs), heart failure, and Raynaud's disease (a condition that causes the blood vessels in the fingers and toes to constrict, leading to pain and discoloration). It is a synthetic form of a substance called prostacyclin, which is naturally produced by the body and helps to relax and widen blood vessels. Epoprostenol is typically administered through an infusion pump that is attached to a vein in the patient's arm or leg. It can also be administered through a nebulizer, which is a device that converts the medication into a fine mist that can be inhaled into the lungs. Epoprostenol is a powerful medication that can cause serious side effects, so it is typically only used in patients who have not responded to other treatments or who have severe medical conditions.
In the medical field, a shock is a life-threatening medical condition characterized by a sudden and severe drop in blood pressure, which results in inadequate blood flow to vital organs and tissues. This can lead to a range of symptoms, including rapid or weak pulse, rapid or shallow breathing, confusion, dizziness, and loss of consciousness. There are several types of shock, including: 1. Hypovolemic shock: This type of shock occurs when the body loses a significant amount of blood or fluid, leading to a drop in blood volume and blood pressure. 2. Cardiogenic shock: This type of shock occurs when the heart is unable to pump enough blood to meet the body's needs, often due to a heart attack or severe heart failure. 3. Distributive shock: This type of shock occurs when the body's blood vessels dilate, leading to a drop in blood pressure and inadequate blood flow to vital organs and tissues. 4. Septic shock: This type of shock occurs when the body's immune system overreacts to an infection, leading to widespread inflammation and damage to organs and tissues. Prompt recognition and treatment of shock are critical to prevent further complications and improve outcomes. Treatment typically involves addressing the underlying cause of the shock, such as administering fluids or medications to increase blood pressure, and providing supportive care to maintain vital organ function.
Receptors, Endothelin are a type of protein receptors found on the surface of cells in the endothelium, which is the inner lining of blood vessels. These receptors are activated by the hormone endothelin, which is produced by cells in the walls of blood vessels and plays a role in regulating blood pressure and blood vessel tone. Activation of endothelin receptors can cause blood vessels to constrict, which can increase blood pressure and reduce blood flow to organs and tissues. Endothelin receptors are also involved in the development of certain cardiovascular diseases, such as hypertension and heart failure.
Angiotensin II is a hormone that plays a crucial role in regulating blood pressure and fluid balance in the body. It is produced by the action of an enzyme called renin on the protein angiotensinogen, which is produced by the liver. Angiotensin II acts on various receptors in the body, including blood vessels, the kidneys, and the adrenal glands, to increase blood pressure and stimulate the release of hormones that help to conserve water and salt. It does this by constricting blood vessels, increasing the amount of sodium and water reabsorbed by the kidneys, and stimulating the release of aldosterone, a hormone that helps to regulate the balance of salt and water in the body. In the medical field, angiotensin II is often used as a diagnostic tool to assess blood pressure and fluid balance in patients. It is also used as a target for the treatment of hypertension (high blood pressure) and other conditions related to fluid and electrolyte balance, such as heart failure and kidney disease. Medications that block the action of angiotensin II, called angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (ACE inhibitors), are commonly used to treat these conditions.
Capillaries are the smallest blood vessels in the body. They are responsible for the exchange of oxygen, nutrients, and waste products between the blood and the body's tissues. Capillaries are so small that red blood cells can only pass through them in single file, and their walls are only one cell thick. This allows for the efficient exchange of substances between the blood and the tissues. Capillaries are found throughout the body, including in the skin, muscles, and organs. They play a crucial role in maintaining the body's overall health and function.
Cerebral veins are blood vessels that drain blood from the brain back to the heart. They are responsible for removing waste products and excess fluid from the brain, and for maintaining the proper balance of fluids and electrolytes in the brain. There are several different types of cerebral veins, including the straight sinus, the cavernous sinus, and the sigmoid sinus. These veins are connected to each other by a network of smaller veins called the venous sinuses. Cerebral veins are an important part of the circulatory system in the brain, and any problems with these veins can have serious consequences. For example, a condition called cerebral venous sinus thrombosis, which is the formation of a blood clot in one of the cerebral veins, can cause headaches, nausea, vomiting, and other symptoms. In severe cases, it can lead to brain damage or even death.
The internal carotid artery is a major blood vessel in the neck that supplies oxygenated blood to the brain. It is one of the two main arteries that originate from the aortic arch and enters the neck through the carotid canal in the temporal bone of the skull. The internal carotid artery then divides into the cavernous sinus and the ophthalmic artery, which supplies blood to the eyes, and the middle cerebral artery, which supplies blood to the majority of the brain. The internal carotid artery is a critical structure in the body, and any damage or blockage to this artery can lead to serious health problems, including stroke.
Arterioles are small blood vessels that branch off from arteries and carry oxygenated blood to the capillaries, which are the smallest blood vessels in the body. They are responsible for regulating blood flow and pressure within the microcirculation, which is the network of blood vessels that supply blood to individual tissues and organs. Arterioles have a diameter of approximately 100-300 micrometers and are lined with smooth muscle cells that can contract or relax to change the diameter of the vessel. This allows for the regulation of blood flow and pressure in response to changes in the body's needs, such as during exercise or in response to changes in blood pressure. Arterioles also play a role in the exchange of nutrients, oxygen, and waste products between the blood and the surrounding tissues. They are an important part of the cardiovascular system and any dysfunction or disease affecting the arterioles can have significant consequences for overall health and wellbeing.
Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, reduce inflammation, and lower fever. It works by inhibiting the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Meclofenamic acid is available in both over-the-counter and prescription forms, and it is typically used to treat conditions such as headaches, menstrual cramps, and osteoarthritis. It may also be used to treat other conditions as determined by a healthcare provider. Common side effects of meclofenamic acid include stomach pain, nausea, vomiting, and diarrhea. In rare cases, it may cause more serious side effects, such as an allergic reaction or an increased risk of bleeding. It is important to follow the instructions provided by a healthcare provider when taking meclofenamic acid and to report any side effects that occur.
In the medical field, purines are a type of organic compound that are found in many foods and are also produced by the body as a natural byproduct of metabolism. Purines are the building blocks of nucleic acids, which are the genetic material in all living cells. They are also important for the production of energy in the body. Purines are classified into two main types: endogenous purines, which are produced by the body, and exogenous purines, which are obtained from the diet. Foods that are high in purines include red meat, organ meats, seafood, and some types of beans and legumes. In some people, the body may not be able to properly break down and eliminate purines, leading to a buildup of uric acid in the blood. This condition, known as gout, can cause pain and inflammation in the joints. High levels of uric acid in the blood can also lead to the formation of kidney stones and other health problems.
Hyperemia is a medical term that refers to an increase in blood flow to a particular area of the body, often resulting in redness, warmth, and swelling. It can occur in response to various stimuli, such as exercise, injury, inflammation, or emotional stress. In the medical field, hyperemia is often used to describe an increase in blood flow to a specific organ or tissue. For example, angina pectoris, a common symptom of coronary artery disease, is caused by hyperemia in the heart muscle. Similarly, hyperemia in the brain can cause headaches or migraines. Hyperemia can also be a sign of a more serious underlying condition, such as a blood clot, infection, or tumor. In these cases, it is important to identify the underlying cause of the hyperemia in order to provide appropriate treatment.
Cardiotonic agents, also known as inotropic agents, are medications that increase the strength and force of contraction of the heart muscle. They are used to treat heart failure, a condition in which the heart is unable to pump enough blood to meet the body's needs. Cardiotonic agents work by increasing the sensitivity of the heart muscle to calcium, which is a key component of muscle contraction. This leads to an increase in the strength and force of the heart's contractions, allowing it to pump more blood and improve cardiac output. Some examples of cardiotonic agents include digitalis, dobutamine, and milrinone.
In the medical field, computer simulation refers to the use of computer models and algorithms to simulate the behavior of biological systems, medical devices, or clinical procedures. These simulations can be used to study and predict the effects of various medical interventions, such as drug treatments or surgical procedures, on the human body. Computer simulations in medicine can be used for a variety of purposes, including: 1. Training and education: Medical students and professionals can use computer simulations to practice and refine their skills in a safe and controlled environment. 2. Research and development: Researchers can use computer simulations to study the underlying mechanisms of diseases and develop new treatments. 3. Clinical decision-making: Physicians can use computer simulations to predict the outcomes of different treatment options and make more informed decisions about patient care. 4. Device design and testing: Engineers can use computer simulations to design and test medical devices, such as prosthetics or surgical instruments, before they are used in patients. Overall, computer simulations are a powerful tool in the medical field that can help improve patient outcomes, reduce costs, and advance medical knowledge.
Milrinone is a medication that is used to treat heart failure and to improve blood flow in the body. It is a type of medication called a phosphodiesterase inhibitor, which works by relaxing the muscles in blood vessels and increasing the strength of heart contractions. Milrinone is usually given as an intravenous infusion, and it can be used to treat both acute and chronic heart failure. It is also sometimes used to treat low blood pressure during surgery.
Endothelin-1 (ET-1) is a potent vasoconstrictor peptide hormone that is primarily produced by endothelial cells in the walls of blood vessels. It plays a key role in regulating blood pressure and blood vessel tone, and is also involved in a variety of other physiological processes, including cell growth and differentiation, inflammation, and angiogenesis (the formation of new blood vessels). In the medical field, ET-1 is often measured as a biomarker for various cardiovascular diseases, such as hypertension, heart failure, and atherosclerosis. It is also used as a therapeutic target in the treatment of these conditions, with drugs such as endothelin receptor antagonists (ERAs) being developed to block the effects of ET-1 and improve cardiovascular outcomes. Additionally, ET-1 has been implicated in the pathogenesis of other diseases, such as cancer and fibrosis, and is being studied as a potential therapeutic target in these conditions as well.
Central venous pressure (CVP) is a measure of the pressure of blood in the central venous system, which includes the superior vena cava, inferior vena cava, and the veins that drain into them. It is typically measured in the right atrium of the heart using a catheter that is inserted through a vein in the neck or groin and advanced into the right atrium. CVP is an important indicator of the volume of blood in the body and can provide information about the function of the heart and the circulatory system. It is often used to monitor patients who are critically ill or who are undergoing surgery, as changes in CVP can indicate fluid balance, cardiac output, and other important factors that can affect a patient's health. A normal CVP is typically between 4 and 12 mmHg, although this can vary depending on the patient's age, weight, and overall health. Abnormal CVP readings can indicate a variety of conditions, including heart failure, fluid overload, and circulatory shock.
Medetomidine is a synthetic alpha-2 adrenergic receptor agonist that is commonly used in veterinary medicine as an anesthetic and analgesic agent. It is also used in human medicine for sedation and anesthesia in certain procedures, such as endoscopy and bronchoscopy. Medetomidine works by binding to alpha-2 adrenergic receptors in the brain and spinal cord, which leads to a decrease in sympathetic nervous system activity and a reduction in heart rate, blood pressure, and respiratory rate. It also produces a calming and sedative effect, making it useful for pre-anesthetic medication and for maintaining anesthesia during procedures. Medetomidine is typically administered intravenously or intramuscularly, and its effects can last for several hours. It is often used in combination with other anesthetic agents to provide a more complete and effective anesthetic.
Cyclic Nucleotide Phosphodiesterases, Type 5 (PDE5) are a group of enzymes that break down cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) in the body. These enzymes play a crucial role in regulating various physiological processes, including blood flow, smooth muscle contraction, and neurotransmission. In the context of sexual function, PDE5 inhibitors are a class of drugs that work by blocking the action of PDE5, thereby increasing levels of cGMP in the penis. This leads to improved blood flow to the penis and helps to achieve and maintain an erection during sexual activity. PDE5 inhibitors are commonly used to treat erectile dysfunction (ED) and are also being studied for other conditions, such as pulmonary hypertension and vision loss.
Hypotension, orthostatic refers to a drop in blood pressure that occurs when a person stands up from a seated or lying position. This type of hypotension is also known as postural hypotension or orthostatic hypotension. When a person stands up, the blood has to work against gravity to pump blood to the brain and other parts of the body. If the blood vessels in the legs and feet do not constrict properly, as they should when a person stands up, the blood may not be able to flow to the brain quickly enough, leading to a drop in blood pressure. Symptoms of orthostatic hypotension may include dizziness, lightheadedness, fainting, and blurred vision. It is more common in older adults, particularly those who are taking certain medications, such as alpha blockers or diuretics, or who have certain medical conditions, such as Parkinson's disease or diabetes. Treatment for orthostatic hypotension may include lifestyle changes, such as drinking plenty of fluids and avoiding standing up too quickly, as well as medications to help constrict blood vessels and increase blood pressure. In severe cases, medical intervention may be necessary to prevent serious complications.
Angiotensin-Converting Enzyme Inhibitors (ACE inhibitors) are a class of drugs used in the medical field to treat high blood pressure (hypertension), heart failure, and to reduce the risk of heart attack and stroke. These drugs work by blocking the action of angiotensin-converting enzyme (ACE), which is an enzyme that converts angiotensin I to angiotensin II. Angiotensin II is a hormone that causes the blood vessels to narrow, which increases blood pressure. By inhibiting ACE, ACE inhibitors help to relax blood vessels and lower blood pressure. They are often used in combination with other blood pressure-lowering medications or diuretics to achieve better blood pressure control.
NG-Nitroarginine Methyl Ester (L-NAME) is a drug that is used in the medical field to study the effects of nitric oxide (NO) on various physiological processes. NO is a naturally occurring gas that plays a role in regulating blood pressure, blood flow, and the immune system. L-NAME is an inhibitor of the enzyme that produces NO, and it is often used to block the effects of NO in experiments. L-NAME is typically administered orally or intravenously, and it can cause a number of side effects, including headache, dizziness, and nausea. It is not recommended for use in pregnant women or individuals with certain medical conditions, such as liver or kidney disease.
In the medical field, a chronic disease is a long-term health condition that persists for an extended period, typically for more than three months. Chronic diseases are often progressive, meaning that they tend to worsen over time, and they can have a significant impact on a person's quality of life. Chronic diseases can affect any part of the body and can be caused by a variety of factors, including genetics, lifestyle, and environmental factors. Some examples of chronic diseases include heart disease, diabetes, cancer, chronic obstructive pulmonary disease (COPD), and arthritis. Chronic diseases often require ongoing medical management, including medication, lifestyle changes, and regular monitoring to prevent complications and manage symptoms. Treatment for chronic diseases may also involve rehabilitation, physical therapy, and other supportive care.
Blood viscosity refers to the thickness or stickiness of blood. It is a measure of the resistance of blood to flow through the blood vessels. Blood viscosity is influenced by several factors, including the number of red blood cells, the amount of plasma in the blood, and the concentration of certain proteins and other substances in the blood. In the medical field, blood viscosity is an important parameter for diagnosing and treating various conditions, such as cardiovascular diseases, blood disorders, and kidney diseases. High blood viscosity can increase the risk of blood clots, stroke, and heart attack, while low blood viscosity can lead to anemia and other conditions. Therefore, measuring blood viscosity is often used as a diagnostic tool to identify and monitor these conditions.
The aorta is the largest artery in the human body, responsible for carrying oxygenated blood from the heart to the rest of the body. It is located in the chest and abdomen and is divided into three main sections: the ascending aorta, the aortic arch, and the descending aorta. The ascending aorta begins at the base of the heart and travels upward to the aortic arch. The aortic arch is a curved section of the aorta that arches over the top of the heart and connects to the descending aorta. The descending aorta continues downward from the aortic arch and eventually branches into smaller arteries that supply blood to the lower body. The aorta is an essential part of the circulatory system and plays a critical role in maintaining overall health and wellbeing. Any damage or disease affecting the aorta can have serious consequences, including heart attack, stroke, and even death.
Nitric oxide synthase (NOS) is an enzyme that plays a crucial role in the production of nitric oxide (NO) in the body. There are three main types of NOS: endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). eNOS is primarily found in the endothelial cells that line blood vessels and is responsible for producing NO in response to various stimuli, such as shear stress, hormones, and neurotransmitters. NO produced by eNOS helps to relax blood vessels and improve blood flow, which is important for maintaining cardiovascular health. nNOS is found in neurons and is involved in neurotransmission and synaptic plasticity. iNOS is induced in response to inflammation and is involved in the production of NO in immune cells and other tissues. Abnormal regulation of NOS activity has been implicated in a variety of diseases, including cardiovascular disease, neurodegenerative disorders, and cancer. Therefore, understanding the mechanisms that regulate NOS activity is an important area of research in the medical field.
Analysis of Variance (ANOVA) is a statistical method used to compare the means of three or more groups. In the medical field, ANOVA can be used to compare the effectiveness of different treatments, interventions, or medications on a particular outcome or variable of interest. For example, a researcher may want to compare the effectiveness of three different medications for treating a particular disease. They could use ANOVA to compare the mean response (e.g., improvement in symptoms) between the three groups of patients who received each medication. If the results show a significant difference between the groups, it would suggest that one medication is more effective than the others. ANOVA can also be used to compare the means of different groups of patients based on a categorical variable, such as age, gender, or race. For example, a researcher may want to compare the mean blood pressure of patients in different age groups. They could use ANOVA to compare the mean blood pressure between the different age groups and determine if there are significant differences. Overall, ANOVA is a powerful statistical tool that can be used to compare the means of different groups in the medical field, helping researchers to identify which treatments or interventions are most effective and to better understand the factors that influence health outcomes.
Hypertrophy of the right ventricle refers to an enlargement of the right ventricle, which is one of the four chambers of the heart. The right ventricle is responsible for pumping oxygen-poor blood from the heart to the lungs, where it is oxygenated. Hypertrophy of the right ventricle can be caused by a variety of factors, including high blood pressure, heart valve disease, and certain genetic conditions. It can also be a complication of other heart conditions, such as pulmonary hypertension or chronic obstructive pulmonary disease (COPD). Symptoms of hypertrophy of the right ventricle may include shortness of breath, fatigue, chest pain, and swelling in the legs and ankles. Treatment depends on the underlying cause and may include medications, lifestyle changes, and in some cases, surgery.
In the medical field, compliance refers to the degree to which a patient follows the recommendations or instructions provided by their healthcare provider. This can include taking medications as prescribed, following a specific diet or exercise regimen, attending regular check-ups, and adhering to any other treatment plans or lifestyle changes recommended by the healthcare provider. Compliance is important because it can impact the effectiveness of medical treatments and the overall health outcomes of patients. Non-compliance with medication regimens, for example, can lead to reduced effectiveness of the medication and an increased risk of complications or side effects. Similarly, non-compliance with lifestyle changes or other treatment recommendations can prevent patients from achieving the best possible outcomes for their health conditions. To promote compliance, healthcare providers may use a variety of strategies, such as providing clear instructions and education about the benefits and risks of treatment, offering support and encouragement, and using reminders or other tools to help patients stay on track with their treatment plan.
Hypertension, renal, also known as renovascular hypertension, is a type of high blood pressure that occurs when there is a problem with the blood vessels that supply the kidneys. This can lead to damage to the kidneys and other health problems. There are two main types of renovascular hypertension: primary and secondary. Primary renovascular hypertension is caused by a narrowing or blockage of the blood vessels that supply the kidneys. This can be due to a variety of factors, including atherosclerosis (hardening of the arteries), fibromuscular dysplasia (a condition that causes abnormal growth of smooth muscle cells in the walls of blood vessels), or a genetic disorder. Secondary renovascular hypertension is caused by an underlying medical condition that affects the kidneys or blood vessels. Examples of conditions that can cause secondary renovascular hypertension include diabetes, high blood pressure, and kidney disease. Treatment for hypertension, renal typically involves medications to lower blood pressure and protect the kidneys. In some cases, surgery may be necessary to remove or repair the damaged blood vessels. It is important to work closely with a healthcare provider to manage this condition and prevent complications.
Fentanyl is a synthetic opioid pain medication that is approximately 100 times more potent than morphine. It is used to treat severe pain, such as that caused by cancer or after surgery. Fentanyl is available in a variety of forms, including tablets, lozenges, patches, and injections. It is also sometimes used in combination with other medications, such as hydromorphone or oxycodone, to increase their effectiveness. Fentanyl can be highly addictive and can cause respiratory depression, which can be life-threatening. It is important to use fentanyl only under the guidance of a healthcare professional and to follow their instructions carefully.
Congenital heart defects (CHDs) are structural abnormalities in the heart that are present at birth. These defects can affect the heart's structure, function, or both, and can range from minor to severe. CHDs are the most common type of birth defect and affect approximately 1 in 100 live births. CHDs can occur in any part of the heart, including the valves, arteries, veins, and chambers. Some common types of CHDs include: - Atrial septal defect (ASD): A hole in the wall between the two upper chambers of the heart. - Ventricular septal defect (VSD): A hole in the wall between the two lower chambers of the heart. - Patent ductus arteriosus (PDA): A blood vessel that remains open between the pulmonary artery and the aorta. - Coarctation of the aorta: A narrowing of the aorta, the main artery that carries blood from the heart to the rest of the body. - Tetralogy of Fallot: A combination of four heart defects that affect the flow of blood through the heart. CHDs can cause a range of symptoms, including shortness of breath, fatigue, chest pain, and heart palpitations. Treatment for CHDs depends on the type and severity of the defect, and may include medications, surgery, or other interventions. Early diagnosis and treatment are important for improving outcomes and reducing the risk of complications.
Cardiac pacing, artificial refers to the medical procedure of implanting a device called a pacemaker into a patient's chest to regulate the heartbeat. The pacemaker is a small electronic device that sends electrical signals to the heart to prompt it to beat at a normal rate. The pacemaker is typically implanted under local anesthesia and can be done on an outpatient basis. The device is connected to the heart through wires called leads, which are placed in the heart's chambers. The pacemaker is then programmed to send electrical signals to the heart at specific intervals to ensure that the heart beats at a normal rate. Artificial cardiac pacing is commonly used to treat patients with bradycardia, a condition in which the heart beats too slowly. It can also be used to treat patients with certain heart conditions, such as heart failure, that cause the heart to beat irregularly. Artificial cardiac pacing can improve a patient's quality of life by reducing symptoms such as fatigue, dizziness, and shortness of breath.
Liver cirrhosis is a chronic liver disease characterized by the replacement of healthy liver tissue with scar tissue, leading to a loss of liver function. This scarring, or fibrosis, is caused by a variety of factors, including chronic alcohol abuse, viral hepatitis, non-alcoholic fatty liver disease, and autoimmune liver diseases. As the liver becomes increasingly damaged, it becomes less able to perform its many functions, such as filtering toxins from the blood, producing bile to aid in digestion, and regulating blood sugar levels. This can lead to a range of symptoms, including fatigue, weakness, abdominal pain, jaundice, and confusion. In advanced cases, liver cirrhosis can lead to liver failure, which can be life-threatening. Treatment options for liver cirrhosis depend on the underlying cause and may include lifestyle changes, medications, and in some cases, liver transplantation.
Sodium is an essential mineral that plays a crucial role in various bodily functions. In the medical field, sodium is often measured in the blood and urine to assess its levels and monitor its balance in the body. Sodium is primarily responsible for regulating the body's fluid balance, which is essential for maintaining blood pressure and proper functioning of the heart, kidneys, and other organs. Sodium is also involved in nerve impulse transmission, muscle contraction, and the production of stomach acid. Abnormal levels of sodium in the body can lead to various medical conditions, including hyponatremia (low sodium levels), hypernatremia (high sodium levels), and dehydration. Sodium levels can be affected by various factors, including diet, medications, and underlying medical conditions. In the medical field, sodium levels are typically measured using a blood test called a serum sodium test or a urine test called a urine sodium test. These tests can help diagnose and monitor various medical conditions related to sodium levels, such as kidney disease, heart failure, and electrolyte imbalances.
Venous insufficiency is a medical condition in which the veins in the legs are unable to effectively pump blood back to the heart. This can cause blood to pool in the veins, leading to swelling, pain, and other symptoms. Venous insufficiency is often caused by damage to the valves in the veins, which can occur due to aging, obesity, pregnancy, or injury. It can also be a complication of other medical conditions, such as varicose veins or deep vein thrombosis. Treatment for venous insufficiency may include lifestyle changes, such as exercise and weight loss, as well as medications and procedures to improve blood flow and reduce symptoms.
Hemoglobins are a group of proteins found in red blood cells (erythrocytes) that are responsible for carrying oxygen from the lungs to the body's tissues and carbon dioxide from the tissues back to the lungs. Hemoglobin is composed of four subunits, each of which contains a heme group that binds to oxygen. The oxygen binds to the iron atom in the heme group, allowing the hemoglobin to transport oxygen throughout the body. Hemoglobin also plays a role in regulating the pH of the blood and in the immune response. Abnormalities in hemoglobin can lead to various medical conditions, such as anemia, sickle cell disease, and thalassemia.
In the medical field, collateral circulation refers to the alternate pathways of blood flow that develop in response to an obstruction or blockage in a major blood vessel. When a blood vessel becomes blocked, blood flow to the affected area is reduced or stopped. In order to maintain blood flow to the area, the body will redirect blood flow through other vessels, creating collateral circulation. Collateral circulation can occur in various parts of the body, including the brain, heart, and limbs. For example, if the main artery to the brain becomes blocked, collateral circulation can develop through smaller blood vessels in the brain, allowing blood to flow to the affected area. Similarly, if the main artery to the heart becomes blocked, collateral circulation can develop through smaller blood vessels in the heart, allowing blood to flow to the heart muscle. Collateral circulation can be beneficial in some cases, as it can help to maintain blood flow to the affected area and prevent tissue damage. However, in other cases, collateral circulation can be a sign of underlying health problems, such as atherosclerosis or a blood clot. In these cases, treatment may be necessary to address the underlying cause of the obstruction and prevent further complications.
In the medical field, "Shock, Septic" refers to a severe and life-threatening condition that occurs when the body's immune system overreacts to an infection, leading to widespread inflammation and damage to organs and tissues. Septic shock is a type of sepsis, which is a condition that occurs when the body's response to an infection causes inflammation throughout the body. In septic shock, the immune system releases large amounts of chemicals that cause blood vessels to narrow and blood pressure to drop, leading to reduced blood flow to vital organs such as the heart, brain, and kidneys. Symptoms of septic shock may include fever, chills, rapid heartbeat, rapid breathing, confusion, and decreased urine output. Treatment for septic shock typically involves antibiotics to treat the underlying infection, fluids and medications to maintain blood pressure and oxygen levels, and supportive care to manage symptoms and prevent complications.,。
Cardiovascular physiological phenomena refer to the various processes and functions that occur within the cardiovascular system, which includes the heart, blood vessels, and blood. These phenomena include the regulation of blood pressure, heart rate, and blood flow, as well as the transport of oxygen, nutrients, and waste products throughout the body. Understanding these physiological phenomena is important for the diagnosis and treatment of cardiovascular diseases and disorders.
The cardiovascular system is a complex network of organs and tissues that work together to pump blood throughout the body. It is responsible for delivering oxygen and nutrients to the body's cells and removing waste products. The main components of the cardiovascular system include the heart, blood vessels (arteries, veins, and capillaries), and blood. The heart is a muscular organ that pumps blood throughout the body. It is divided into four chambers: the right atrium, right ventricle, left atrium, and left ventricle. The right side of the heart pumps deoxygenated blood to the lungs, where it picks up oxygen and releases carbon dioxide. The left side of the heart pumps oxygenated blood to the rest of the body. Blood vessels are responsible for transporting blood throughout the body. Arteries carry oxygenated blood away from the heart, while veins carry deoxygenated blood back to the heart. Capillaries are tiny blood vessels that connect arteries and veins and allow for the exchange of oxygen, nutrients, and waste products between the blood and body tissues. Together, the heart, blood vessels, and blood make up the cardiovascular system, which is essential for maintaining the health and function of the body.
Enalapril is an angiotensin-converting enzyme (ACE) inhibitor that is used in the medical field to treat high blood pressure (hypertension), heart failure, and to improve survival after a heart attack. It works by blocking the action of ACE, which helps to relax blood vessels and lower blood pressure. Enalapril is available in oral tablet form and is typically taken once or twice a day, depending on the condition being treated and the individual patient's needs. It is generally well-tolerated, but like all medications, it can cause side effects, such as dizziness, cough, and fatigue.
Pulmonary edema is a medical condition characterized by the accumulation of excess fluid in the lungs. This can occur due to a variety of factors, including heart failure, kidney failure, severe dehydration, and certain medications. Pulmonary edema can cause shortness of breath, coughing, and difficulty breathing, and can be life-threatening if left untreated. Treatment typically involves addressing the underlying cause of the edema and providing supportive care to help the body eliminate the excess fluid.
Intratracheal anesthesia is a type of anesthesia that involves administering an anesthetic agent directly into the trachea, or windpipe, of a patient. This method of anesthesia is typically used in emergency situations where other forms of anesthesia may not be feasible or appropriate, such as in cases of severe trauma or respiratory distress. During intratracheal anesthesia, the anesthetic agent is typically delivered through a small tube called an endotracheal tube, which is inserted into the trachea through the mouth or nose. The anesthetic agent is then delivered through the tube, and the patient is rendered unconscious. Intratracheal anesthesia is typically used in conjunction with other forms of anesthesia, such as general anesthesia, to ensure that the patient remains unconscious and pain-free throughout the procedure. It is important to note that intratracheal anesthesia is a highly specialized technique that should only be performed by trained medical professionals in a controlled medical setting.
Prostaglandins are a group of hormone-like substances that are produced in the body from fatty acids. They play a variety of roles in the body, including regulating inflammation, blood pressure, and pain. Prostaglandins are synthesized in cells throughout the body, including in the lining of the stomach, the lungs, and the reproductive organs. They are also produced in response to injury or infection, and are thought to play a role in the body's healing process. Prostaglandins are often used as medications to reduce inflammation and pain, and are also used to prevent blood clots and to induce labor in pregnant women.
Tetrazoles are a class of organic compounds that contain a five-membered ring with four nitrogen atoms and one carbon atom. They have a variety of applications in the medical field, including as antimicrobial agents, anticancer drugs, and as inhibitors of enzymes involved in various biological processes. One example of a tetrazole-based drug is linezolid, which is an antibiotic used to treat bacterial infections, including pneumonia, skin infections, and bone and joint infections. Linezolid works by inhibiting the production of bacterial proteins, which are essential for the bacteria's survival. Tetrazoles are also being investigated as potential treatments for cancer. For example, some tetrazole derivatives have been shown to selectively target and kill cancer cells, while sparing healthy cells. Additionally, tetrazoles have been found to have anti-inflammatory and analgesic properties, which could make them useful in the treatment of pain and other inflammatory conditions. Overall, tetrazoles are a versatile class of compounds with a wide range of potential applications in the medical field.
Phenylpropionates are a class of drugs that are used in the medical field as appetite suppressants and to treat obesity. They work by inhibiting the enzyme that breaks down certain neurotransmitters in the brain, which can lead to a feeling of fullness and a reduction in appetite. Phenylpropionates are also sometimes used to treat conditions such as depression and attention deficit hyperactivity disorder (ADHD). Some examples of phenylpropionates include benzphetamine, diethylpropion, and mazindol. These drugs are typically prescribed for short-term use and can have side effects such as dry mouth, headache, and insomnia.
Aortic valve stenosis is a medical condition in which the aortic valve, which is located between the left ventricle of the heart and the aorta, becomes narrowed or hardened, making it difficult for blood to flow from the heart to the rest of the body. This can lead to an increase in blood pressure in the left ventricle, which can cause the heart to work harder to pump blood through the narrowed valve. Over time, this can cause the heart muscle to become thickened and weakened, which can lead to heart failure. Aortic valve stenosis is typically caused by the buildup of calcium deposits or other substances on the valve, and it is more common in older adults. Treatment options for aortic valve stenosis may include medications, lifestyle changes, or surgery to replace the damaged valve.
Ritodrine is a medication that is used to prevent and treat preterm labor. It is a beta-adrenergic receptor agonist that works by relaxing the smooth muscles of the uterus, which can help to slow down or stop labor. Ritodrine is typically given intravenously in a hospital setting, and it is usually used for short-term treatment only. It can cause side effects such as dizziness, headache, and rapid heartbeat, and it may not be suitable for everyone.
The Endothelin A receptor (ETA receptor) is a protein that is found on the surface of cells in the body, particularly in the endothelium (the inner lining of blood vessels). It is a type of G protein-coupled receptor, which means that it is activated by a molecule called an agonist, such as endothelin-1, and triggers a series of cellular responses. The ETA receptor plays a role in regulating blood pressure and blood vessel tone, and is also involved in the development and progression of certain diseases, such as hypertension, heart failure, and atherosclerosis. Activation of the ETA receptor can cause vasoconstriction (narrowing of blood vessels), which can increase blood pressure, and can also stimulate the release of other signaling molecules that can contribute to inflammation and tissue damage. In the medical field, the ETA receptor is an important target for the development of drugs that are used to treat cardiovascular diseases. For example, some drugs that block the ETA receptor, such as bosentan and ambrisentan, are used to treat pulmonary hypertension, a condition in which blood pressure in the lungs is abnormally high.
Ventricular remodeling refers to the structural and functional changes that occur in the heart's ventricles (the lower chambers of the heart) in response to various factors such as heart disease, injury, or genetic predisposition. These changes can include thickening of the heart muscle, enlargement of the ventricles, and changes in the electrical activity of the heart. Ventricular remodeling can lead to a variety of heart conditions, including heart failure, arrhythmias, and sudden cardiac death. It is a complex process that involves multiple cellular and molecular mechanisms, including inflammation, fibrosis, and changes in gene expression. In the medical field, ventricular remodeling is an important area of research, as it can help identify new targets for the prevention and treatment of heart disease. Treatment options for ventricular remodeling may include medications, lifestyle changes, and in some cases, surgical interventions.
Teprotide is a synthetic peptide that was developed as a potential treatment for peptic ulcers. It works by inhibiting the production of hydrochloric acid in the stomach, which can help to reduce the pain and inflammation associated with ulcers. Teprotide is typically administered as an intravenous injection and is used to treat severe cases of peptic ulcers that have not responded to other treatments. It is also sometimes used to prevent the development of ulcers in people who are taking nonsteroidal anti-inflammatory drugs (NSAIDs) or other medications that can increase the risk of ulcers. However, teprotide is no longer widely used due to the availability of other, more effective treatments for peptic ulcers.
Anoxia is a medical condition characterized by a lack of oxygen in the body's tissues. This can occur due to a variety of factors, including low oxygen levels in the air, reduced blood flow to the tissues, or a lack of oxygen-carrying red blood cells. Anoxia can lead to a range of symptoms, including confusion, dizziness, shortness of breath, and loss of consciousness. In severe cases, anoxia can be life-threatening and may require immediate medical attention.
In the medical field, the brain is the most complex and vital organ in the human body. It is responsible for controlling and coordinating all bodily functions, including movement, sensation, thought, emotion, and memory. The brain is located in the skull and is protected by the skull bones and cerebrospinal fluid. The brain is composed of billions of nerve cells, or neurons, which communicate with each other through electrical and chemical signals. These neurons are organized into different regions of the brain, each with its own specific functions. The brain is also divided into two hemispheres, the left and right, which are connected by a bundle of nerve fibers called the corpus callosum. Damage to the brain can result in a wide range of neurological disorders, including stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, and epilepsy. Treatment for brain disorders often involves medications, surgery, and rehabilitation therapies to help restore function and improve quality of life.
Anesthesia, General is a medical procedure that involves the administration of drugs to induce a state of unconsciousness and analgesia (pain relief) during a surgical or medical procedure. The goal of general anesthesia is to render the patient unconscious and unable to feel pain or respond to stimuli, allowing the surgical or medical team to perform the procedure without the patient experiencing discomfort or distress. During general anesthesia, the patient is typically administered a combination of medications, including anesthetics, muscle relaxants, and sedatives, through an intravenous (IV) line or through inhalation. The anesthetics used during general anesthesia can vary depending on the patient's age, weight, medical history, and the type of procedure being performed. After the procedure, the patient is typically awakened by administering a reversal agent to counteract the effects of the anesthetics. The patient will then be monitored for a period of time to ensure that they have fully recovered from the anesthesia before being discharged from the hospital or surgical center.
Angiotensin receptor antagonists (ARAs) are a class of medications used in the medical field to treat high blood pressure (hypertension) and heart failure. These drugs work by blocking the action of angiotensin II, a hormone that narrows blood vessels and increases blood pressure. By blocking this hormone, ARAs help to relax blood vessels and lower blood pressure, which can reduce the risk of heart attack, stroke, and other complications associated with hypertension and heart failure. ARAs are available in both oral and injectable forms and are often used in combination with other blood pressure-lowering medications.
The aortic valve is a one-way valve located at the exit of the left ventricle of the heart. It is responsible for preventing the backflow of blood from the aorta, the main artery that carries blood away from the heart, back into the left ventricle. The aortic valve is made up of three flaps, or cusps, that open and close in response to changes in pressure within the heart. When the left ventricle contracts, the aortic valve opens, allowing blood to flow into the aorta. When the left ventricle relaxes, the aortic valve closes, preventing blood from flowing back into the left ventricle. The aortic valve plays a critical role in maintaining the proper flow of blood throughout the body.
Lypressin is a medication used to treat symptoms of benign prostatic hyperplasia (BPH), a condition in which the prostate gland becomes enlarged, causing difficulty urinating. It contains the active ingredient terazosin, which works by relaxing the muscles in the prostate and bladder neck, allowing urine to flow more easily. Lypressin is typically taken once daily, and its side effects may include dizziness, headache, fatigue, and low blood pressure. It is important to follow the dosage instructions provided by your healthcare provider and to inform them of any other medications you are taking before starting Lypressin.
Cardiopulmonary bypass (CPB) is a surgical procedure that is used to support the heart and lungs during certain types of heart surgery. During CPB, a machine is used to take over the function of the heart and lungs, allowing the surgeon to perform the necessary procedures on the heart without the risk of the patient's organs failing due to lack of oxygen or blood flow. The CPB machine works by pumping oxygenated blood from the patient's body to the heart, where it is then pumped out to the rest of the body. At the same time, the machine removes carbon dioxide from the blood and returns it to the patient's body. This allows the surgeon to work on the heart without the patient's organs being starved of oxygen or blood flow. CPB is typically used during procedures such as heart valve surgery, coronary artery bypass surgery, and heart transplant surgery. It is a complex procedure that requires specialized training and equipment, and is typically performed by a team of highly skilled medical professionals in a hospital setting.
Sodium chloride, also known as table salt, is a chemical compound composed of sodium and chlorine ions. It is a white, odorless, and crystalline solid that is commonly used as a seasoning and preservative in food. In the medical field, sodium chloride is used as a medication to treat a variety of conditions, including dehydration, electrolyte imbalances, and certain types of heart failure. It is also used as a contrast agent in diagnostic imaging procedures such as X-rays and CT scans. Sodium chloride is available in various forms, including oral solutions, intravenous solutions, and topical ointments. It is important to note that excessive consumption of sodium chloride can lead to high blood pressure and other health problems, so it is important to use it only as directed by a healthcare professional.
Sulfonamides are a class of synthetic antimicrobial drugs that were first discovered in the 1930s. They are commonly used to treat a variety of bacterial infections, including urinary tract infections, respiratory infections, and skin infections. Sulfonamides work by inhibiting the production of folic acid by bacteria, which is essential for their growth and reproduction. They are often used in combination with other antibiotics to increase their effectiveness. Sulfonamides are generally well-tolerated, but can cause side effects such as nausea, vomiting, and allergic reactions in some people.
Carotid stenosis is a medical condition in which the carotid artery, which supplies blood to the brain, becomes narrowed or blocked. This can lead to a reduced flow of blood to the brain, which can cause symptoms such as dizziness, weakness, and difficulty speaking or thinking. Carotid stenosis is typically caused by the buildup of plaque in the walls of the artery, which can thicken and harden over time. Other risk factors for carotid stenosis include high blood pressure, smoking, and diabetes. Treatment for carotid stenosis may include medication to manage symptoms and prevent further narrowing of the artery, or surgery to remove the plaque and restore blood flow to the brain.
Prostaglandin antagonists are a class of drugs that block the effects of prostaglandins, which are hormone-like substances that play a role in various physiological processes in the body, including inflammation, pain, and blood clotting. Prostaglandin antagonists are used to treat a variety of conditions, including asthma, allergic reactions, and certain types of pain. They work by inhibiting the production of prostaglandins or by blocking the receptors that prostaglandins bind to, thereby reducing their effects. Examples of prostaglandin antagonists include aspirin, ibuprofen, and naproxen.
Hypertension, renovascular, is a type of high blood pressure that is caused by problems with the blood vessels that supply blood to the kidneys. These blood vessels, called the renal arteries, can become narrowed or blocked by a variety of factors, including atherosclerosis (the buildup of plaque in the arteries), fibromuscular dysplasia (a condition in which the walls of the blood vessels are abnormally thickened), or a kidney tumor. When the renal arteries are narrowed or blocked, it can reduce the amount of blood flow to the kidneys, which can cause the kidneys to work harder to filter blood. This increased workload can lead to high blood pressure. Hypertension, renovascular, is a serious condition that can cause damage to the kidneys and other organs if left untreated. It is typically treated with medications to lower blood pressure and, in some cases, with procedures to open or bypass narrowed or blocked renal arteries.
The carotid arteries are two major blood vessels in the neck that supply oxygenated blood to the brain and other parts of the head and neck. They are located on either side of the neck, just below the Adam's apple, and are responsible for approximately 15% of the total blood flow to the brain. The carotid arteries begin as two small arteries in the chest, called the internal carotid arteries, which then travel up the neck and join together to form the common carotid artery. The common carotid artery then branches off into the internal and external carotid arteries. The internal carotid artery supplies blood to the brain, while the external carotid artery supplies blood to the face, neck, and upper extremities. The carotid arteries are important for maintaining proper blood flow to the brain, which is essential for cognitive function, balance, and coordination. Damage or blockage of the carotid arteries can lead to serious health problems, including stroke.
Omega-N-Methylarginine (L-NMMA) is a synthetic compound that is structurally similar to the amino acid L-arginine. L-arginine is an important precursor for the production of nitric oxide (NO), a molecule that plays a crucial role in regulating blood flow and blood pressure. L-NMMA inhibits the production of NO by competing with L-arginine for the enzyme that catalyzes the conversion of L-arginine to NO. As a result, L-NMMA can reduce NO levels in the body, leading to vasoconstriction (narrowing of blood vessels) and an increase in blood pressure. L-NMMA has been used in research studies to investigate the role of NO in various physiological and pathophysiological processes, including cardiovascular disease, hypertension, and erectile dysfunction. However, it is not currently used as a therapeutic agent in clinical practice.
Ciliary arteries are small blood vessels that supply blood to the ciliary body, which is a part of the eye responsible for regulating the shape of the lens and producing aqueous humor. There are two ciliary arteries, one on each side of the eye, that arise from the ophthalmic artery, which is a branch of the internal carotid artery. The ciliary arteries are very small and thin, and they are often difficult to visualize during medical procedures. They are important for maintaining the health of the ciliary body and the eye as a whole.
Angiography is a medical imaging technique used to visualize the blood vessels in the body. It involves injecting a contrast dye into a blood vessel, usually through a small puncture in the skin, and then using an X-ray machine or other imaging device to capture images of the dye as it flows through the blood vessels. This allows doctors to see any blockages, narrowing, or other abnormalities in the blood vessels, which can help them diagnose and treat a variety of medical conditions, including heart disease, stroke, and cancer. Angiography is often used in conjunction with other imaging techniques, such as computed tomography (CT) or magnetic resonance imaging (MRI), to provide a more complete picture of the patient's condition.
Myocardial infarction (MI), also known as a heart attack, is a medical condition that occurs when blood flow to a part of the heart muscle is blocked, usually by a blood clot. This lack of blood flow can cause damage to the heart muscle, which can lead to serious complications and even death if not treated promptly. The most common cause of a heart attack is atherosclerosis, a condition in which plaque builds up in the arteries that supply blood to the heart. When a plaque ruptures or becomes unstable, it can form a blood clot that blocks the flow of blood to the heart muscle. Other causes of heart attacks include coronary artery spasms, blood clots that travel to the heart from other parts of the body, and certain medical conditions such as Kawasaki disease. Symptoms of a heart attack may include chest pain or discomfort, shortness of breath, nausea or vomiting, lightheadedness or dizziness, and pain or discomfort in the arms, back, neck, jaw, or stomach. If you suspect that you or someone else is having a heart attack, it is important to call emergency services immediately. Early treatment with medications and possibly surgery can help to reduce the risk of serious complications and improve the chances of a full recovery.
Blood volume determination is a medical procedure used to measure the amount of blood present in the circulatory system of an individual. This measurement is important for several reasons, including monitoring fluid balance, diagnosing and treating conditions such as dehydration or overhydration, and assessing the effectiveness of certain medical treatments. There are several methods used to determine blood volume, including: 1. Total body water (TBW) measurement: This method involves measuring the total amount of water in the body, which includes the blood volume. 2. Hematocrit: This is the percentage of red blood cells in the blood. A high hematocrit indicates a high blood volume, while a low hematocrit indicates a low blood volume. 3. Plasma volume: This is the volume of fluid in the blood that is not contained within red blood cells. Plasma volume can be measured using a dye that is injected into the bloodstream and then monitored as it is filtered out of the blood by the kidneys. 4. Radionuclide labeling: This method involves injecting a radioactive substance into the bloodstream and then measuring the amount of radiation emitted by the substance as it is filtered out of the blood by the kidneys. Blood volume determination is typically performed using one of these methods or a combination of them. The results of the test can be used to diagnose and treat a variety of medical conditions, including dehydration, heart failure, and kidney disease.
In the medical field, consciousness refers to an individual's awareness of their surroundings, thoughts, and emotions. It is the subjective experience of being awake and aware of one's environment, thoughts, and feelings. Consciousness is often assessed through various clinical measures, such as the Glasgow Coma Scale, which evaluates a patient's level of consciousness based on their eye opening, verbal response, and motor response to stimuli. Consciousness is a complex and multifaceted phenomenon that is not yet fully understood by scientists. It is thought to involve the activity of various brain regions, including the prefrontal cortex, thalamus, and brainstem. Disorders of consciousness, such as coma, vegetative state, and minimally conscious state, can result from damage to these brain regions and can have significant implications for a patient's quality of life and prognosis.
Halothane is a general anesthetic that was widely used in the past for surgical procedures. It is a colorless, volatile liquid that is inhaled to produce unconsciousness and a lack of sensation during surgery. Halothane works by blocking the transmission of nerve impulses in the brain, which leads to a loss of consciousness and muscle relaxation. Halothane was first introduced in the 1950s and was widely used for many years due to its effectiveness and relatively low cost. However, it has since been largely replaced by other anesthetics due to concerns about its potential side effects, including liver damage, respiratory depression, and cardiac arrhythmias. Despite these concerns, halothane is still used in some parts of the world, particularly in developing countries where access to other anesthetics may be limited. It is also used in veterinary medicine for certain procedures.
Cross-over studies are a type of clinical trial design in which a single subject serves as their own control. In other words, the subject is exposed to two or more treatments or interventions, and the effects of each treatment are compared within the same individual. The main advantage of cross-over studies is that they can reduce the number of subjects needed to obtain reliable results, as each subject serves as their own control. This can be particularly useful in situations where it is difficult or unethical to recruit a large number of subjects, or where the study requires a long duration of treatment. However, cross-over studies can also have limitations, such as carryover effects, where the effects of one treatment may persist after the subject has been switched to a different treatment. Additionally, the order in which treatments are administered can affect the results, and statistical methods must be used to account for this. Cross-over studies are commonly used in the medical field to evaluate the effectiveness and safety of new drugs, medical devices, and other interventions. They can also be used to compare different dosages or formulations of a treatment, or to evaluate the effectiveness of a treatment in different patient populations.
Anesthesia, Inhalation refers to a type of anesthesia that is induced by inhaling gases or vaporized medications that produce a state of unconsciousness, analgesia (pain relief), and muscle relaxation. Inhalational anesthesia is commonly used in surgical procedures and other medical procedures that require the patient to be unconscious. The most commonly used inhalational anesthetics are halogenated hydrocarbons, such as sevoflurane, isoflurane, and desflurane. These gases are administered through a mask or a breathing tube that is placed in the patient's trachea. The patient inhales the gas, which is then absorbed into the bloodstream and carried to the brain, where it produces a state of anesthesia. Inhalational anesthesia is generally considered safe and effective when administered by trained medical professionals. However, like all forms of anesthesia, it carries some risks, including allergic reactions, respiratory depression, and nausea and vomiting.
Esophageal and gastric varices are abnormal blood vessels that develop in the lining of the esophagus and stomach. They are typically caused by liver disease, such as cirrhosis, which can lead to high blood pressure in the veins of the liver and the development of varices. These varices can become enlarged and twisted, and if they rupture, they can cause internal bleeding that can be life-threatening. Treatment for esophageal and gastric varices may include medications to reduce blood pressure in the veins, endoscopic procedures to band or remove the varices, or surgery to repair or replace damaged veins.
Cardiac output (CO) is the amount of blood pumped by the heart per minute, typically measured in liters per minute (L/min). Low cardiac output refers to a condition where the heart is not pumping enough blood to meet the body's needs. This can be caused by a variety of factors, including heart failure, low blood volume, severe anemia, and certain medications. Symptoms of low cardiac output may include shortness of breath, fatigue, dizziness, and decreased urine output. Treatment for low cardiac output depends on the underlying cause and may include medications, fluid replacement, or surgery.
Carbonic anhydrase inhibitors (CAIs) are a class of drugs that are used to treat a variety of medical conditions, including glaucoma, altitude sickness, and certain types of epilepsy. These drugs work by inhibiting the activity of an enzyme called carbonic anhydrase, which is involved in the production of bicarbonate ions in the body. By inhibiting this enzyme, CAIs can help to lower the production of bicarbonate ions, which can help to reduce the pressure inside the eye in the case of glaucoma, or help to reduce the symptoms of altitude sickness by reducing the body's production of carbon dioxide. CAIs are also sometimes used to treat certain types of epilepsy by reducing the frequency and severity of seizures.
Hypertension, malignant, is a severe form of high blood pressure that is characterized by consistently high blood pressure levels that are resistant to treatment. Malignant hypertension is a medical emergency that can lead to serious complications, including damage to the kidneys, brain, and eyes, as well as heart failure and stroke. The term "malignant" refers to the fact that this form of hypertension is aggressive and can progress rapidly, leading to severe and potentially life-threatening complications if not treated promptly and effectively. Malignant hypertension is typically defined as blood pressure levels that are consistently greater than 180/120 mmHg, despite the use of multiple medications to lower blood pressure. Symptoms of malignant hypertension may include severe headache, vision loss, confusion, and chest pain. Treatment typically involves aggressive management of blood pressure through a combination of medications, as well as close monitoring of kidney function and other organ systems that may be affected by the high blood pressure. Early detection and prompt treatment are critical for preventing serious complications and improving outcomes in patients with malignant hypertension.
In the medical field, "baths" typically refers to a type of medical treatment in which a person is submerged in a warm or hot water bath. This type of treatment is often used to help relieve pain, reduce muscle tension, and promote relaxation. There are several different types of baths that may be used in medical treatment, including: 1. Hydrotherapy baths: These baths use warm or hot water to help relieve pain and reduce inflammation. They may be used to treat a variety of conditions, including arthritis, fibromyalgia, and chronic pain. 2. Epsom salt baths: These baths use a solution of magnesium sulfate (epsom salt) to help relieve muscle pain and tension. They may be used to treat conditions such as muscle cramps, soreness, and spasms. 3. Dead sea salt baths: These baths use a solution of salt from the Dead Sea to help relieve dry skin, eczema, and other skin conditions. They may also help to reduce inflammation and promote relaxation. 4. Milk baths: These baths use a mixture of warm water and milk to help soothe and moisturize the skin. They may be used to treat conditions such as eczema, psoriasis, and dry skin. 5. Lavender baths: These baths use a solution of lavender oil to help promote relaxation and reduce stress. They may be used to treat conditions such as insomnia, anxiety, and depression. It's important to note that while baths can be a helpful treatment for certain conditions, they should not be used as a substitute for medical treatment. If you are experiencing pain or other symptoms, it's important to speak with a healthcare provider to determine the best course of treatment.
Anesthetics are drugs that are used to produce a state of temporary unconsciousness or insensitivity to pain during medical procedures or surgery. They are typically administered by a healthcare professional, such as a doctor or nurse, and are used to help patients relax, feel more comfortable, and tolerate medical procedures without experiencing pain or discomfort. There are several types of anesthetics, including general anesthetics, which produce a state of complete unconsciousness, and local anesthetics, which numb a specific area of the body. General anesthetics are further divided into inhalational anesthetics, which are breathed in through a mask or tube, and injectable anesthetics, which are administered through a needle. Anesthetics are an essential part of modern medicine and are used in a wide range of medical procedures, including surgeries, dental procedures, and childbirth. However, they can also have side effects, such as nausea, vomiting, dizziness, and difficulty breathing, and can be dangerous if not administered properly. Therefore, it is important for healthcare professionals to be trained in the safe and effective use of anesthetics.
Coronary vessels, also known as coronary arteries, are blood vessels that supply oxygen-rich blood to the heart muscle. There are two main coronary arteries, the left coronary artery and the right coronary artery, which branch off from the aorta and travel through the heart muscle to supply blood to the heart's various chambers and valves. The coronary arteries are responsible for delivering oxygen and nutrients to the heart muscle, which is essential for its proper function. If the coronary arteries become narrowed or blocked due to atherosclerosis (the buildup of plaque), it can lead to a condition called coronary artery disease (CAD), which can cause chest pain, heart attack, and other serious cardiovascular problems. In some cases, coronary artery disease can be treated with medications, lifestyle changes, or procedures such as angioplasty or coronary artery bypass surgery. It is important to maintain a healthy lifestyle, including regular exercise, a balanced diet, and not smoking, to reduce the risk of developing coronary artery disease and other cardiovascular problems.
Cerebral angiography is a medical imaging procedure used to visualize the blood vessels in the brain. It involves injecting a contrast dye into the bloodstream, which highlights the blood vessels on X-ray images. This allows doctors to identify any blockages, narrowing, or aneurysms in the blood vessels that may be causing symptoms such as headaches, seizures, or stroke. Cerebral angiography is typically performed as an outpatient procedure and is used to diagnose and treat a variety of neurological conditions, including stroke, aneurysms, and tumors. It is considered a safe and effective diagnostic tool, but like any medical procedure, it carries some risks, including bleeding, infection, and allergic reactions to the contrast dye.
Captopril is a medication that is used to treat high blood pressure (hypertension) and heart failure. It is a type of drug called an angiotensin-converting enzyme (ACE) inhibitor. ACE inhibitors work by blocking the production of angiotensin II, a hormone that causes blood vessels to narrow and blood pressure to rise. By blocking the production of angiotensin II, captopril helps to relax blood vessels and lower blood pressure. Captopril is usually taken by mouth, and the dosage may be adjusted based on the patient's blood pressure and other medical conditions. It is important to take captopril exactly as prescribed by a healthcare provider, as stopping the medication suddenly can cause blood pressure to rise again. Captopril may cause side effects such as dizziness, headache, cough, and fatigue. In rare cases, it can cause more serious side effects such as angioedema (swelling of the face, lips, tongue, or throat) or low blood pressure. It is important to talk to a healthcare provider about any side effects that occur while taking captopril.
Moyamoya disease is a rare cerebrovascular disorder that affects the blood vessels in the brain. It is characterized by the narrowing or occlusion of the internal carotid artery and its branches, which can lead to decreased blood flow to the brain. This can cause a variety of symptoms, including headaches, dizziness, seizures, and stroke. Moyamoya disease is typically diagnosed through a combination of medical history, physical examination, and imaging tests such as magnetic resonance imaging (MRI) or computed tomography (CT) scans. Treatment for Moyamoya disease may include medications to manage symptoms, surgery to improve blood flow to the brain, or a combination of both.
Dilated cardiomyopathy is a medical condition characterized by the enlargement and weakening of the heart muscle, specifically the ventricles, which are the lower chambers of the heart responsible for pumping blood out to the rest of the body. This enlargement causes the heart to become weakened and unable to pump blood efficiently, leading to symptoms such as shortness of breath, fatigue, and swelling in the legs and ankles. Dilated cardiomyopathy can be caused by a variety of factors, including genetics, infections, alcohol and drug abuse, and certain medications. It can also be a complication of other heart conditions, such as hypertension or coronary artery disease. Diagnosis of dilated cardiomyopathy typically involves a physical examination, electrocardiogram (ECG), echocardiogram, and other imaging tests. Treatment may include medications to improve heart function, lifestyle changes such as a heart-healthy diet and exercise, and in some cases, surgery or heart transplantation.
Artificial organs are medical devices or implants that are designed to replace or assist a functioning organ in the human body. These devices are typically used when a person's natural organ is damaged, diseased, or has failed to function properly. Artificial organs can be classified into two main categories: 1. Replacement organs: These are devices that are designed to replace a damaged or diseased organ entirely. Examples include artificial hearts, lungs, kidneys, and livers. 2. Assistive organs: These are devices that are designed to assist a functioning organ in some way. Examples include artificial pacemakers, which help regulate the heart's rhythm, and artificial limbs, which help people with amputations perform daily activities. Artificial organs are typically made from materials such as plastic, metal, or silicone, and are designed to mimic the function of the natural organ they are replacing or assisting. They may be implanted surgically or used externally, depending on the specific device and the condition being treated. Artificial organs can be a life-saving option for people with serious medical conditions, but they also come with risks and potential complications.
Contrast media are substances that are used to enhance the visibility of certain structures or organs in medical imaging procedures, such as X-rays, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound. These substances are typically introduced into the body through injection, ingestion, or inhalation, and they work by altering the way that X-rays or other imaging waves interact with the tissues they pass through. There are several different types of contrast media, including iodinated contrast agents, gadolinium-based contrast agents, and barium sulfate. Iodinated contrast agents are the most commonly used type of contrast media and are typically used to enhance the visibility of blood vessels, organs, and other structures in the body. Gadolinium-based contrast agents are used in MRI scans to enhance the visibility of certain tissues, while barium sulfate is used in X-rays to outline the digestive tract. Contrast media are generally considered safe and effective when used appropriately, but they can cause side effects in some people, such as allergic reactions, nausea, and kidney problems. It is important for patients to discuss the potential risks and benefits of contrast media with their healthcare provider before undergoing an imaging procedure that involves the use of these substances.
In the medical field, an acute disease is a condition that develops suddenly and progresses rapidly over a short period of time. Acute diseases are typically characterized by severe symptoms and a high degree of morbidity and mortality. Examples of acute diseases include pneumonia, meningitis, sepsis, and heart attacks. These diseases require prompt medical attention and treatment to prevent complications and improve outcomes. In contrast, chronic diseases are long-term conditions that develop gradually over time and may persist for years or even decades.
Autonomic nerve block is a medical procedure that involves blocking the transmission of signals from the autonomic nervous system to a specific area of the body. The autonomic nervous system is responsible for regulating involuntary bodily functions such as heart rate, blood pressure, digestion, and breathing. Autonomic nerve blocks are commonly used to treat various conditions such as chronic pain, migraines, and certain types of headaches. The procedure involves injecting a local anesthetic or a combination of local anesthetic and a muscle relaxant into the affected area. This blocks the transmission of signals from the autonomic nerves to the targeted area, which can help to reduce pain and other symptoms. Autonomic nerve blocks are typically performed on an outpatient basis and can be done using various techniques, including ultrasound guidance or electrical stimulation. The procedure is generally safe and well-tolerated, although there is a small risk of complications such as infection, bleeding, or nerve damage.
Arginine is an amino acid that plays a crucial role in various physiological processes in the human body. It is an essential amino acid, meaning that it cannot be synthesized by the body and must be obtained through the diet. In the medical field, arginine is used to treat a variety of conditions, including: 1. Erectile dysfunction: Arginine is a precursor to nitric oxide, which helps to relax blood vessels and improve blood flow to the penis, leading to improved sexual function. 2. Cardiovascular disease: Arginine has been shown to improve blood flow and reduce the risk of cardiovascular disease by lowering blood pressure and improving the function of the endothelium, the inner lining of blood vessels. 3. Wound healing: Arginine is involved in the production of collagen, a protein that is essential for wound healing. 4. Immune function: Arginine is involved in the production of antibodies and other immune system components, making it important for maintaining a healthy immune system. 5. Cancer: Arginine has been shown to have anti-cancer properties and may help to slow the growth of tumors. However, it is important to note that the use of arginine as a supplement is not without risks, and it is important to consult with a healthcare provider before taking any supplements.
Thromboxane B2 is a potent vasoconstrictor and platelet aggregator that is produced by platelets and other cells in response to injury or inflammation. It plays a key role in the formation of blood clots and is involved in various cardiovascular diseases, such as atherosclerosis, myocardial infarction, and stroke. Thromboxane B2 is also a potent stimulator of uterine contractions during pregnancy and can contribute to the development of preterm labor.
Endothelins are a group of vasoactive peptides that are produced by endothelial cells, which are the cells that line the blood vessels. There are three main endothelins: endothelin-1, endothelin-2, and endothelin-3. These peptides are synthesized as larger precursor proteins that are cleaved into smaller, active peptides by enzymes. Endothelins have a number of effects on the cardiovascular system, including vasoconstriction (narrowing of blood vessels), increased heart rate, and increased blood pressure. They also have effects on other organs, such as the kidneys and the lungs. Endothelins play a role in a number of physiological processes, including blood pressure regulation, fluid balance, and the immune response. They are also involved in a number of pathological conditions, including hypertension, heart failure, and pulmonary hypertension. In the medical field, endothelin antagonists are drugs that block the effects of endothelins on the cardiovascular system. These drugs are used to treat a variety of conditions, including pulmonary hypertension and heart failure.
The cerebrum is the largest part of the brain and is responsible for many of the higher functions of the nervous system, including perception, thought, emotion, and movement. It is divided into two hemispheres, which are connected by a thick bundle of nerve fibers called the corpus callosum. Each hemisphere is further divided into four lobes: the frontal, parietal, temporal, and occipital lobes. The cerebrum is also responsible for controlling voluntary movements, processing sensory information, and regulating autonomic functions such as heart rate and breathing. Damage to the cerebrum can result in a wide range of neurological symptoms, depending on the location and extent of the injury.
Anesthetics, Inhalation are drugs that are administered through the lungs to produce a state of unconsciousness, analgesia, and amnesia during surgical or other medical procedures. These drugs are typically delivered through a mask or a breathing tube and work by depressing the central nervous system, reducing the patient's awareness and responsiveness to pain and other stimuli. Inhalational anesthetics are commonly used in surgery and other medical procedures because they can be quickly and easily administered, have a rapid onset and recovery time, and can be easily titrated to the desired level of anesthesia. Some common examples of inhalational anesthetics include halothane, isoflurane, and sevoflurane.
Pathologic constriction refers to a medical condition in which a blood vessel or other tubular structure becomes narrowed or blocked, leading to reduced blood flow or obstruction of the flow of other substances through the vessel. This can occur due to a variety of factors, including inflammation, scarring, abnormal growths, or the presence of a foreign object. Pathologic constriction can have serious consequences, depending on the location and severity of the constriction, and may require medical intervention to treat.
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, reduce inflammation, and lower fever. It works by blocking the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Indomethacin is available in various forms, including tablets, capsules, and suppositories. It is often prescribed for conditions such as arthritis, menstrual cramps, and headaches. It can also be used to treat gout, kidney stones, and other inflammatory conditions. However, indomethacin can have side effects, including stomach pain, nausea, vomiting, and diarrhea. It can also increase the risk of bleeding and ulcers in the stomach and intestines. Therefore, it is important to use indomethacin only as directed by a healthcare provider and to report any side effects immediately.
Ventricular dysfunction, left, is a medical condition in which the left ventricle of the heart is unable to pump blood efficiently. The left ventricle is responsible for pumping oxygen-rich blood from the heart to the rest of the body. When it is not functioning properly, it can lead to a variety of symptoms, including shortness of breath, fatigue, and chest pain. There are several causes of left ventricular dysfunction, including heart attacks, high blood pressure, coronary artery disease, and heart valve problems. Treatment for left ventricular dysfunction depends on the underlying cause and may include medications, lifestyle changes, and in some cases, surgery. Left ventricular dysfunction can be a serious condition and requires prompt medical attention.
Monocrotaline is a toxic alkaloid found in the seeds of certain plants, including the jimsonweed (Datura stramonium) and the thornapple (Datura innoxia). It is primarily used as a research tool in the medical field to induce pulmonary hypertension, a condition characterized by high blood pressure in the lungs, which can lead to heart failure and other serious complications. Monocrotaline is administered to laboratory animals, such as rats and mice, to study the pathophysiology of pulmonary hypertension and to test potential treatments for the condition. It works by stimulating the proliferation of cells in the walls of blood vessels in the lungs, leading to thickening and narrowing of the vessels, increased resistance to blood flow, and elevated blood pressure. While monocrotaline is a valuable tool for research, it is important to note that it is a highly toxic substance and should only be handled by trained professionals in a controlled laboratory setting.
Furosemide is a medication that is used to treat fluid retention (edema) and high blood pressure (hypertension). It is a type of diuretic, which means that it increases the amount of urine that the body produces. This helps to reduce the amount of fluid in the body and lower blood pressure. Furosemide is also used to treat heart failure, liver disease, and some types of kidney disease. It is usually taken by mouth, but it can also be given intravenously (by injection into a vein). Furosemide is a relatively potent diuretic and can cause side effects such as dehydration, low blood pressure, and electrolyte imbalances. It is important to follow the dosage instructions provided by your healthcare provider and to let them know if you experience any side effects while taking furosemide.
Renal artery obstruction is a medical condition in which there is a blockage or narrowing of the renal artery, which is the main blood vessel that supplies blood to the kidneys. This can occur due to a variety of factors, including atherosclerosis (hardening of the arteries), fibromuscular dysplasia (a condition in which the walls of the arteries become thick and abnormal), renal artery stenosis (narrowing of the renal artery), or kidney stones that have moved and become lodged in the renal artery. Renal artery obstruction can lead to a decrease in blood flow to the kidneys, which can cause damage to the kidneys and impair their ability to filter waste products from the blood. This can lead to a range of symptoms, including blood in the urine, high blood pressure, and kidney failure. Treatment for renal artery obstruction may include medications to lower blood pressure and cholesterol, angioplasty (a procedure in which a balloon is inflated to widen a narrowed or blocked artery), or surgery to remove the blockage or repair the damaged artery.
Vasopressins are a group of hormones that are produced by the hypothalamus and released by the posterior pituitary gland. They play a key role in regulating blood pressure and fluid balance in the body. There are two main types of vasopressins: arginine vasopressin (AVP) and desmopressin (DDAVP). AVP is primarily responsible for regulating water balance in the body, while DDAVP is used to treat certain types of bleeding disorders. Vasopressins work by constricting blood vessels, which increases blood pressure. They also stimulate the kidneys to retain water, which helps to maintain blood volume and blood pressure. In addition, vasopressins can affect the heart rate and contractility, as well as the permeability of blood vessels. Abnormal levels of vasopressins can lead to a variety of medical conditions, including diabetes insipidus, which is characterized by excessive thirst and urination, and central diabetes insipidus, which is caused by a deficiency of AVP. Vasopressin levels can also be affected by certain medications, such as diuretics, and by certain medical conditions, such as heart failure and kidney disease.
Dobutamine is a medication that is used to increase the strength of the heart's contractions and to increase the heart's rate. It is a synthetic form of dopamine, a hormone that is naturally produced by the body to help regulate blood pressure and heart function. Dobutamine is typically used to treat heart failure, a condition in which the heart is unable to pump blood effectively throughout the body. It is also sometimes used to treat low blood pressure (hypotension) and to increase blood flow to the heart muscle after a heart attack. Dobutamine is usually given intravenously, and the dosage is adjusted based on the patient's response and any side effects that may occur.
Cerebral revascularization is a medical procedure that involves improving blood flow to the brain in order to treat or prevent stroke. This can be done through a variety of methods, including surgery, angioplasty, and the use of stents or other devices to open up blocked or narrowed blood vessels in the brain. The goal of cerebral revascularization is to increase the amount of oxygen and nutrients that reach the brain, which can help to prevent further damage and improve the outcome for patients who have suffered a stroke. It is typically performed in cases where other treatments have been unsuccessful or are not possible, and it may be recommended for patients who are at high risk of stroke due to factors such as a history of stroke, high blood pressure, or atherosclerosis.
Nicardipine is a calcium channel blocker medication that is used to treat high blood pressure (hypertension) and angina (chest pain). It works by relaxing the blood vessels, which allows blood to flow more easily and reduces the workload on the heart. Nicardipine is available in both oral and intravenous forms, and it is usually taken once or twice a day. It is also used to treat certain types of heart rhythm disorders, such as atrial fibrillation.
In the medical field, "Administration, Inhalation" refers to the process of delivering medication or other substances to the lungs through inhalation. This method of administration is commonly used to treat respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and pneumonia, as well as to provide relief from respiratory symptoms such as coughing, wheezing, and shortness of breath. Inhalation administration can be achieved through a variety of devices, including inhalers, nebulizers, and vaporizers. Inhalers are portable devices that contain medication in the form of a powder or liquid that is aerosolized and inhaled through the mouth. Nebulizers, on the other hand, use compressed air to turn medication into a fine mist that is inhaled through a mouthpiece or mask. Vaporizers are devices that heat up liquid medication to produce a vapor that is inhaled. Inhalation administration has several advantages over other methods of medication delivery, including faster onset of action, more targeted delivery of medication to the lungs, and reduced systemic side effects. However, it can also have potential drawbacks, such as the risk of respiratory irritation or infection, and the need for proper technique and device maintenance to ensure effective delivery of medication.
Cardiopulmonary Resuscitation (CPR) is a life-saving technique used to restore breathing and circulation in a person who has stopped breathing or whose heart has stopped beating. CPR involves chest compressions to pump blood and artificial ventilation to provide oxygen to the lungs. The goal of CPR is to keep the brain and other vital organs alive until emergency medical services arrive and can provide further treatment, such as defibrillation or advanced life support. CPR is typically performed on an unconscious person who is not breathing or has a weak pulse, and it is most effective when performed immediately after the person stops breathing or their heart stops.
Dihydralazine is a medication that is used to treat high blood pressure (hypertension) and heart failure. It is a type of drug called a dihydropyridine calcium channel blocker, which works by relaxing blood vessels and allowing blood to flow more easily. This helps to lower blood pressure and improve the function of the heart. Dihydralazine is usually taken by mouth, but it can also be given as an injection. It is important to follow the instructions of your healthcare provider when taking this medication. Side effects of dihydralazine may include headache, dizziness, and nausea.
Respiratory Distress Syndrome (RDS) is a medical condition that occurs when the lungs are unable to function properly, leading to difficulty breathing and low levels of oxygen in the blood. In adults, RDS is a rare condition that can occur as a complication of certain medical conditions or procedures, such as severe trauma, surgery, or infections. The symptoms of RDS in adults may include shortness of breath, rapid breathing, chest pain, coughing, and bluish skin or lips. The diagnosis of RDS is typically made based on a combination of clinical symptoms, medical history, and diagnostic tests, such as chest X-rays and blood tests. Treatment for RDS in adults typically involves providing oxygen therapy to increase the amount of oxygen in the blood, as well as medications to reduce inflammation and improve lung function. In severe cases, mechanical ventilation may be necessary to help the lungs function properly. The prognosis for RDS in adults depends on the underlying cause and the severity of the condition, but with prompt and appropriate treatment, most people are able to recover fully.
The Circle of Willis is a critical blood vessel structure in the brain that supplies blood to the brain and surrounding structures. It is a network of arteries that form a circle around the base of the brain, where they branch off to supply blood to different regions of the brain. The Circle of Willis is essential for maintaining blood flow to the brain and ensuring that it receives the oxygen and nutrients it needs to function properly. Any damage or disruption to the Circle of Willis can lead to serious neurological problems, including stroke and brain injury.
Capillary permeability refers to the ability of fluid and solutes to pass through the walls of capillaries, which are the smallest blood vessels in the body. Capillary permeability is an important factor in regulating blood flow and maintaining fluid balance in the body. There are two types of capillary permeability: hydrostatic and osmotic. Hydrostatic permeability refers to the ability of fluid to move through the capillary walls under the influence of pressure gradients. Osmotic permeability refers to the ability of solutes to move through the capillary walls due to differences in solute concentration between the inside and outside of the capillary. Abnormalities in capillary permeability can lead to a variety of medical conditions, including edema (swelling), inflammation, and certain types of circulatory disorders. For example, increased capillary permeability can cause fluid to leak out of the capillaries and accumulate in tissues, leading to edema. Conversely, decreased capillary permeability can lead to poor blood flow and tissue ischemia (lack of oxygen and nutrients). In the medical field, capillary permeability is often measured using techniques such as the Evans blue dye test or the albumin permeability test. These tests involve injecting a dye or protein into the bloodstream and measuring its uptake by the capillary walls, which can provide information about the permeability of the capillaries.
Ventricular dysfunction is a medical condition in which the heart's ventricles, the lower chambers responsible for pumping blood out of the heart, are unable to function properly. This can result in a decrease in the amount of blood that is pumped out of the heart with each beat, leading to symptoms such as shortness of breath, fatigue, and swelling in the legs and ankles. There are several types of ventricular dysfunction, including systolic dysfunction, which occurs when the ventricles are unable to contract effectively, and diastolic dysfunction, which occurs when the ventricles are unable to relax and fill with blood properly. Ventricular dysfunction can be caused by a variety of factors, including heart disease, heart attack, high blood pressure, and certain genetic conditions. Treatment for ventricular dysfunction typically involves medications to improve heart function and lifestyle changes such as a healthy diet and regular exercise. In severe cases, surgery may be necessary.
Indocyanine Green (ICG) is a fluorescent dye that is commonly used in the medical field for a variety of diagnostic and therapeutic purposes. It is a water-soluble, non-toxic dye that is administered intravenously and is rapidly taken up by the liver, where it is metabolized and excreted. ICG is often used in liver function tests to assess liver blood flow and to detect liver disease. It is also used in ophthalmology to evaluate the health of the retina and to guide laser surgery for conditions such as age-related macular degeneration and diabetic retinopathy. In addition, ICG is used in interventional radiology to guide the placement of catheters and stents in the liver and to detect liver tumors. ICG is also used in some surgical procedures, such as liver transplantation, to help surgeons identify healthy liver tissue and to guide the placement of liver grafts. It is a valuable tool in the medical field because of its ability to provide real-time, non-invasive information about organ function and tissue health.
Thromboxanes are a group of lipid-derived signaling molecules that are produced by platelets and other cells in response to injury or inflammation. They are synthesized from arachidonic acid, which is an essential fatty acid that is found in cell membranes. There are two main types of thromboxanes: thromboxane A2 (TXA2) and thromboxane B2 (TXB2). TXA2 is a potent vasoconstrictor and platelet aggregator, which means that it causes blood vessels to narrow and platelets to stick together, respectively. It also promotes the formation of blood clots, which can help to stop bleeding after an injury. TXB2 is a breakdown product of TXA2 and is used as a marker of platelet activation. It is also a potent vasoconstrictor and platelet aggregator, but its effects are generally weaker than those of TXA2. Thromboxanes play an important role in the body's response to injury and inflammation, but they can also contribute to the development of certain medical conditions, such as cardiovascular disease and thrombosis. Medications that inhibit the production or action of thromboxanes are used to treat these conditions.
Pyridazines are a class of heterocyclic compounds that contain a six-membered ring with five carbon atoms and one nitrogen atom. They are commonly used in the medical field as pharmaceuticals and as intermediates in the synthesis of other drugs. Some examples of pyridazine derivatives used in medicine include: 1. Pyridoxine (vitamin B6): A water-soluble vitamin that plays a crucial role in the metabolism of amino acids, lipids, and carbohydrates. 2. Pyridostigmine: A cholinesterase inhibitor used to treat myasthenia gravis, a neuromuscular disorder. 3. Pyrimethamine: An antimalarial drug that inhibits the growth of Plasmodium parasites. 4. Pyrazinamide: An antitubercular drug used to treat tuberculosis. 5. Pyrazinamide: A diuretic used to treat hypertension and edema. Pyridazines have a wide range of pharmacological activities and are used in the treatment of various diseases, including infections, neurological disorders, and metabolic disorders.
Piperazines are a class of organic compounds that contain a six-membered ring with two nitrogen atoms. They are commonly used in the medical field as drugs and are known for their anticholinergic, antispasmodic, and sedative properties. Some examples of piperazine-based drugs include antihistamines, antipsychotics, and antidiarrheals. Piperazines can also be used as intermediates in the synthesis of other drugs.
Blood vessels are the tubes that carry blood throughout the body. There are three main types of blood vessels: arteries, veins, and capillaries. Arteries are the blood vessels that carry oxygen-rich blood away from the heart to the body's tissues and organs. They are thick-walled and muscular, and their walls are lined with smooth muscle that can contract to help push blood through the vessels. Veins are the blood vessels that carry oxygen-poor blood back to the heart from the body's tissues and organs. They are thinner-walled than arteries and have valves that prevent blood from flowing backward. Capillaries are the smallest blood vessels in the body, and they connect arteries and veins. They are extremely thin and have walls that are only one cell thick, which allows for the exchange of oxygen, nutrients, and waste products between the blood and the body's tissues. Blood vessels play a critical role in maintaining the body's overall health and function. They help regulate blood pressure, transport oxygen and nutrients to the body's tissues, and remove waste products from the body.
Heart arrest is a medical emergency that occurs when the heart stops beating effectively, resulting in a lack of blood flow to the body's vital organs. This can happen suddenly or gradually, and it can be caused by a variety of factors, including heart disease, electrical abnormalities in the heart, trauma, or certain medications. In heart arrest, the heart's electrical activity is disrupted, and the heart muscle is unable to contract and pump blood. This can lead to a loss of consciousness, respiratory arrest, and death if not treated promptly. Treatment for heart arrest typically involves cardiopulmonary resuscitation (CPR), which involves chest compressions and rescue breathing to try to restore blood flow to the body and the heart. In some cases, defibrillation may also be necessary to shock the heart back into a normal rhythm. If the heart arrest is caused by an underlying medical condition, such as a heart attack or arrhythmia, additional treatment may be required to address the underlying cause.
Cardiovascular surgical procedures refer to surgeries performed on the heart and blood vessels to treat various cardiovascular conditions. These procedures may involve repairing or replacing damaged heart valves, performing coronary artery bypass surgery, repairing or replacing aortic aneurysms, or treating other conditions affecting the heart and blood vessels. Cardiovascular surgeons are medical professionals who specialize in performing these types of procedures and are trained to diagnose and treat a wide range of cardiovascular conditions.
Xenon is a noble gas that is used in the medical field for various purposes, including anesthesia and neuroprotection. It is a colorless, odorless, and non-toxic gas that is administered through inhalation. In anesthesia, xenon is used as an alternative to other anesthetic gases, such as sevoflurane and isoflurane. It has several advantages over these gases, including faster induction and recovery times, lower blood pressure, and less respiratory depression. Xenon is also used in neuroprotection, where it is believed to protect the brain from damage caused by stroke, traumatic brain injury, and other conditions. In addition to its use in anesthesia and neuroprotection, xenon is also being studied for its potential use in treating other medical conditions, such as depression, anxiety, and Alzheimer's disease.
Cardiac surgical procedures refer to a range of surgical techniques used to treat various heart conditions. These procedures are typically performed by cardiothoracic surgeons and may involve the use of minimally invasive techniques or open surgery. Some common cardiac surgical procedures include: 1. Coronary artery bypass surgery: This procedure involves using a healthy blood vessel from another part of the body to bypass a blocked or narrowed coronary artery, which can improve blood flow to the heart muscle. 2. Valve replacement or repair: This procedure involves replacing or repairing damaged heart valves, which can improve blood flow through the heart. 3. Heart transplant: This procedure involves replacing a damaged or diseased heart with a healthy heart from a donor. 4. Ablation: This procedure involves using heat, cold, or radiofrequency energy to destroy abnormal heart tissue that is causing irregular heart rhythms. 5. Maze procedure: This procedure involves creating a series of small cuts in the heart to create a maze-like pattern that can help prevent abnormal heart rhythms. 6. Heart bypass surgery: This procedure involves using a healthy blood vessel from another part of the body to bypass a blocked or narrowed coronary artery, which can improve blood flow to the heart muscle. These procedures are typically performed under general anesthesia and may require a hospital stay of several days or more. The specific procedure and recovery time will depend on the individual patient's condition and the type of surgery performed.
Nitroprusside is a medication that is used to treat high blood pressure (hypertension) and heart failure. It is a type of drug called a nitrovasodilator, which works by relaxing the blood vessels and allowing blood to flow more easily. This can help to lower blood pressure and improve the function of the heart. Nitroprusside is usually given as an intravenous (IV) injection, although it can also be given as a tablet or a liquid to swallow. It is usually used in the hospital setting, but it may also be used at home if a person's blood pressure is very high and needs to be lowered quickly. It is important to note that nitroprusside can cause side effects, including headache, dizziness, and low blood pressure. It should only be used under the supervision of a healthcare professional.
A bioprosthesis is a medical device made from biological materials, such as animal tissue or human cells, that is used to replace or repair damaged or diseased body parts. Bioprostheses are often used in surgical procedures to replace or repair heart valves, blood vessels, and other organs or tissues. They are typically designed to mimic the natural structure and function of the body part they are replacing, and are intended to be temporary or permanent implants. Bioprostheses can be made from a variety of materials, including pig heart valves, cow pericardium (the outer lining of the heart), and human cells grown in a laboratory. They are typically used in patients who are not good candidates for mechanical prostheses, which are made from artificial materials and require regular maintenance and replacement.
Intracranial Arteriovenous Malformations (AVMs) are abnormal connections between arteries and veins in the brain. These connections can cause blood to flow in the wrong direction, leading to high blood pressure and an increased risk of stroke, seizures, and other complications. AVMs can occur anywhere in the brain, but they are most commonly found in the brainstem, cerebellum, and temporal lobes. They can be congenital (present at birth) or acquired (developing later in life). Treatment options for AVMs include medication, radiation therapy, and surgery.
Intravenous anesthesia is a type of anesthesia that is administered through a vein in the patient's arm or hand. It involves the use of medications that are delivered directly into the bloodstream to induce a state of unconsciousness and analgesia (pain relief) during a medical procedure or surgery. The medications used in intravenous anesthesia can vary depending on the specific needs of the patient and the type of procedure being performed. Common medications used in intravenous anesthesia include propofol, midazolam, fentanyl, and rocuronium. Intravenous anesthesia is typically used in conjunction with other forms of anesthesia, such as local anesthesia or regional anesthesia, to provide comprehensive pain relief and ensure the patient's safety and comfort during surgery or other medical procedures.
Losartan is a medication used to treat high blood pressure (hypertension) and to reduce the risk of stroke in people with high blood pressure and diabetes. It belongs to a class of drugs called angiotensin II receptor blockers (ARBs), which work by relaxing blood vessels and decreasing the workload on the heart. Losartan is also used to treat heart failure and to reduce the risk of heart attack in people who have had a heart attack or who have certain risk factors for heart disease. It is usually taken once or twice a day, with or without food. Common side effects of losartan include headache, dizziness, and cough.
Proteinuria is a medical condition characterized by the presence of excess protein in the urine. Normally, the kidneys filter waste products and excess fluids from the blood, but they also retain most of the protein in the blood. When the kidneys are damaged or diseased, they may not be able to filter the protein properly, leading to proteinuria. Proteinuria can be classified as either microscopic or macroscopic. Microscopic proteinuria refers to the presence of small amounts of protein in the urine, typically less than 150 mg per day. Macroscopic proteinuria, on the other hand, refers to the presence of larger amounts of protein in the urine, typically greater than 150 mg per day. Proteinuria can be caused by a variety of medical conditions, including kidney disease, diabetes, high blood pressure, and certain infections. It is often an indicator of underlying kidney damage or disease and can lead to serious complications if left untreated. Treatment for proteinuria depends on the underlying cause and may include medications, lifestyle changes, and in some cases, dialysis or kidney transplantation.
Aldosterone is a hormone produced by the adrenal gland, which is located on top of the kidneys. It plays a crucial role in regulating the balance of salt and water in the body, and helps to maintain blood pressure and blood volume. Aldosterone acts on the kidneys to increase the reabsorption of sodium ions and the excretion of potassium ions. This helps to conserve water and increase blood volume, which in turn raises blood pressure. Aldosterone also stimulates the production of renin, another hormone that helps to regulate blood pressure. In addition to its role in fluid and electrolyte balance, aldosterone also has other effects on the body. It can stimulate the growth of blood vessels and the production of red blood cells, and it can also affect the metabolism of glucose and lipids. Aldosterone is often measured in the blood as a diagnostic tool for conditions such as Addison's disease, Cushing's syndrome, and primary aldosteronism. It is also used as a treatment for certain types of hypertension and heart failure.
Biomedical engineering is an interdisciplinary field that combines engineering principles with medical and biological sciences to develop innovative solutions for healthcare problems. It involves the application of engineering techniques and tools to understand, diagnose, treat, and prevent diseases and injuries. Biomedical engineers work on a wide range of projects, including designing medical devices and equipment, developing new imaging techniques, creating prosthetics and orthotics, developing new drugs and drug delivery systems, and analyzing biological data to improve patient outcomes. The field of biomedical engineering is constantly evolving, with new technologies and techniques being developed all the time. Biomedical engineers work in a variety of settings, including hospitals, research institutions, and private companies, and collaborate with a range of professionals, including doctors, nurses, and other healthcare providers.
Adrenergic alpha-agonists are drugs that bind to and activate alpha-adrenergic receptors, which are a type of G protein-coupled receptor found in various tissues throughout the body. These receptors are involved in a wide range of physiological processes, including the regulation of blood pressure, heart rate, and smooth muscle contraction. When an adrenergic alpha-agonist binds to an alpha-adrenergic receptor, it causes the receptor to activate a signaling cascade that ultimately leads to the production of cyclic AMP (cAMP). This increase in cAMP can cause a variety of effects, depending on the specific tissue and receptor subtype involved. For example, in the heart, alpha-adrenergic receptor activation can increase heart rate and contractility, while in the blood vessels, it can cause vasoconstriction (narrowing of the blood vessels). Adrenergic alpha-agonists are used in a variety of medical settings, including the treatment of hypertension, heart failure, and bronchospasm (narrowing of the airways in the lungs). They are also used as part of anesthesia to help control blood pressure and heart rate during surgery. Some examples of adrenergic alpha-agonists include epinephrine, norepinephrine, and phenylephrine.
Eclampsia is a serious complication of pregnancy that can occur in women who have high blood pressure (hypertension) during pregnancy. It is characterized by seizures, usually grand mal seizures, which can be life-threatening for both the mother and the baby. Eclampsia is caused by a combination of factors, including high blood pressure, protein in the urine (proteinuria), and swelling (edema). These factors can lead to damage to the placenta, which can cause the baby to receive less oxygen and nutrients. Symptoms of eclampsia can include severe headaches, blurred vision, abdominal pain, and sudden changes in blood pressure. If left untreated, eclampsia can lead to seizures, coma, and even death. Treatment for eclampsia typically involves managing the high blood pressure with medication, administering anticonvulsant drugs to prevent seizures, and closely monitoring the mother and baby for any signs of complications. In severe cases, hospitalization and delivery of the baby may be necessary.
The external carotid artery is a major artery in the neck that supplies blood to the head and neck. It branches off from the common carotid artery, which is located in the neck, and runs along the side of the neck towards the face. The external carotid artery gives rise to several smaller arteries, including the maxillary artery, the facial artery, and the superficial temporal artery, which supply blood to the face, scalp, and jaw. The external carotid artery is a vital blood vessel, and any damage to it can lead to serious health problems, including stroke and loss of blood flow to the head and neck.
"Sodium, Dietary" refers to the amount of sodium (also known as sodium chloride) that is consumed in a person's diet. Sodium is an essential nutrient that plays a crucial role in maintaining fluid balance, transmitting nerve impulses, and regulating blood pressure. However, excessive intake of sodium can lead to health problems such as high blood pressure, heart disease, and stroke. In the medical field, dietary sodium intake is often measured in milligrams (mg) per day. The recommended daily intake of sodium for adults is around 2,300 mg per day, although some people may need less or more depending on their age, sex, health status, and other factors. The American Heart Association recommends that adults aim for a sodium intake of no more than 1,500 mg per day to reduce the risk of high blood pressure and other health problems. Monitoring dietary sodium intake is important for managing conditions such as hypertension (high blood pressure) and heart failure. Healthcare providers may recommend sodium-restricted diets for patients with these conditions, and may also recommend monitoring sodium intake through dietary records or other methods.
The abdominal aorta is the largest artery in the human body, responsible for carrying oxygenated blood from the heart to the lower half of the body, including the abdominal organs, legs, and feet. It is located in the abdominal cavity, between the diaphragm and the pelvic floor, and is approximately 10-12 inches long. The abdominal aorta begins at the level of the aortic hiatus in the diaphragm, where it emerges from the thoracic aorta. It then passes through the abdominal cavity, where it is surrounded by a layer of connective tissue called the adventitia. The abdominal aorta branches into several smaller arteries, including the superior mesenteric artery, the renal arteries, and the common iliac arteries. Abnormalities of the abdominal aorta can lead to a variety of medical conditions, including aneurysms, dissections, and occlusions. These conditions can be serious and may require medical intervention, such as surgery or endovascular procedures.
Natriuretic Peptide, Brain (NPB) is a hormone that is produced by the brain and released into the bloodstream. It is a member of the natriuretic peptide family, which also includes atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). NPB has several functions in the body, including regulating blood pressure, fluid balance, and heart rate. It works by inhibiting the release of renin, a hormone that stimulates the production of angiotensin II, which in turn constricts blood vessels and increases blood pressure. NPB also has a role in the regulation of the autonomic nervous system, which controls heart rate and blood pressure. It can stimulate the release of nitric oxide, a molecule that helps to relax blood vessels and lower blood pressure. In the medical field, NPB is being studied as a potential diagnostic tool for various cardiovascular diseases, including heart failure and hypertension. It may also have therapeutic potential for these conditions, as it has been shown to improve cardiac function and reduce blood pressure in animal models.
Hyperoxia is a medical condition characterized by an excessive amount of oxygen in the body. It occurs when the body is exposed to higher levels of oxygen than it can handle or when the body is not able to effectively remove excess oxygen from the bloodstream. In the medical field, hyperoxia can be caused by a variety of factors, including breathing pure oxygen at high concentrations, exposure to high altitude, or certain medical treatments such as oxygen therapy. Symptoms of hyperoxia can include headache, confusion, dizziness, seizures, and in severe cases, respiratory distress or failure. Treatment for hyperoxia typically involves reducing the amount of oxygen being administered or providing supportive care to manage symptoms.
Ventricular dysfunction, right refers to a medical condition where the right ventricle of the heart is not functioning properly. The right ventricle is responsible for pumping blood from the heart to the lungs, where it receives oxygen and gets rid of carbon dioxide. When the right ventricle is not functioning properly, it can lead to a decrease in the amount of blood that is pumped to the lungs, which can cause a variety of symptoms and complications. There are several different causes of right ventricular dysfunction, including heart valve problems, heart muscle damage, and heart rhythm disorders. Treatment for right ventricular dysfunction depends on the underlying cause and may include medications, lifestyle changes, and in some cases, surgery. It is important to seek medical attention if you are experiencing symptoms of right ventricular dysfunction, as early diagnosis and treatment can help to improve outcomes and prevent complications.
Cardiac volume refers to the amount of blood that is contained within the heart at any given time. It is an important parameter in the assessment of cardiac function and can be measured using various imaging techniques such as echocardiography, computed tomography (CT), and magnetic resonance imaging (MRI). There are three main types of cardiac volumes: stroke volume, end-diastolic volume, and end-systolic volume. Stroke volume is the amount of blood pumped out of the heart with each beat, while end-diastolic volume is the amount of blood in the heart at the end of the relaxation phase (diastole) of the cardiac cycle. End-systolic volume is the amount of blood remaining in the heart at the end of the contraction phase (systole) of the cardiac cycle. Abnormalities in cardiac volume can indicate various cardiac diseases or conditions, such as heart failure, valvular heart disease, or myocardial infarction (heart attack). Therefore, accurate measurement of cardiac volume is crucial for the diagnosis and management of these conditions.
Adenosine is a naturally occurring nucleoside that plays a crucial role in various physiological processes in the human body. It is a component of the nucleic acids DNA and RNA and is also found in high concentrations in the cells of the heart, brain, and other organs. In the medical field, adenosine is often used as a medication to treat certain heart conditions, such as supraventricular tachycardia (SVT) and atrial fibrillation (AFib). Adenosine works by blocking the electrical signals that cause the heart to beat too fast or irregularly. It is typically administered as an intravenous injection and has a short duration of action, lasting only a few minutes. Adenosine is also used in research to study the function of various cells and tissues in the body, including the nervous system, immune system, and cardiovascular system. It has been shown to have a wide range of effects on cellular signaling pathways, including the regulation of gene expression, cell proliferation, and apoptosis (cell death).
Imidazoles are a class of organic compounds that contain a five-membered heterocyclic ring with two nitrogen atoms and three carbon atoms. In the medical field, imidazoles are commonly used as antifungal agents, particularly for the treatment of dermatophytic infections such as athlete's foot, ringworm, and jock itch. They work by inhibiting the growth of fungi by interfering with their metabolism. One of the most well-known imidazole antifungal agents is clotrimazole, which is used topically to treat skin and nail infections caused by fungi. Other imidazole antifungal agents include miconazole, ketoconazole, and itraconazole, which are used to treat a variety of fungal infections, including systemic infections such as cryptococcal meningitis and aspergillosis. Imidazoles are also used in other medical applications, such as in the treatment of parasitic infections, as well as in the development of new drugs for the treatment of cancer and other diseases.
Isothiuronium is a chemical compound that contains a sulfur atom bonded to a nitrogen atom, which is in turn bonded to a carbon atom. In the medical field, isothiuronium compounds are often used as local anesthetics, which are drugs that are used to numb a specific area of the body during medical procedures or surgeries. They work by blocking the transmission of pain signals from the nerves to the brain. Some examples of isothiuronium compounds that are used as local anesthetics include lidocaine, bupivacaine, and prilocaine. These drugs are typically administered by injection into the skin or near the site of the procedure.
Epinephrine, also known as adrenaline, is a hormone and neurotransmitter that plays a crucial role in the body's "fight or flight" response. It is produced by the adrenal glands and is released into the bloodstream in response to stress or danger. In the medical field, epinephrine is used as a medication to treat a variety of conditions, including anaphylaxis (a severe allergic reaction), cardiac arrest, and asthma. It works by constricting blood vessels, increasing heart rate and contractility, and relaxing smooth muscles in the bronchial tubes, which can help to open airways and improve breathing. Epinephrine is typically administered via injection, either intravenously or subcutaneously (under the skin). It is a powerful medication and should only be used under the guidance of a healthcare professional.
Intravenous anesthetics are medications that are administered directly into a patient's bloodstream through a vein to induce anesthesia. These medications work by altering the patient's consciousness and reducing their awareness of pain and other sensations during surgery or other medical procedures. There are several types of intravenous anesthetics, including: 1. Barbiturates: These medications are commonly used to induce anesthesia and to maintain anesthesia during surgery. They work by slowing down the central nervous system and reducing consciousness. 2. Benzodiazepines: These medications are often used in combination with other anesthetics to reduce anxiety and to produce a deeper level of anesthesia. 3. Propofol: This medication is commonly used to induce anesthesia and to maintain anesthesia during surgery. It works by slowing down the central nervous system and reducing consciousness. 4. Ketamine: This medication is often used to induce anesthesia in emergency situations or in patients who are difficult to anesthetize. It works by altering the patient's perception of pain and reducing their awareness of their surroundings. Intravenous anesthetics are typically administered by a trained healthcare professional, such as an anesthesiologist or a nurse anesthetist, in a hospital or surgical setting. The dosage and type of anesthetic used will depend on the patient's age, weight, medical history, and the type of procedure being performed.
Arterial occlusive diseases refer to a group of medical conditions in which the arteries become narrowed or blocked, leading to reduced blood flow to the affected area. This can result in a range of symptoms, depending on the location and severity of the blockage. The most common types of arterial occlusive diseases include: 1. Atherosclerosis: A condition in which plaque builds up inside the arteries, causing them to narrow and harden. 2. Peripheral artery disease (PAD): A condition that affects the arteries in the legs, causing pain, cramping, and weakness in the legs, especially during physical activity. 3. Coronary artery disease (CAD): A condition that affects the arteries that supply blood to the heart, leading to chest pain, shortness of breath, and other symptoms. 4. Carotid artery disease: A condition that affects the arteries in the neck, leading to a reduced blood flow to the brain, which can cause stroke. Treatment for arterial occlusive diseases may include lifestyle changes, such as quitting smoking, eating a healthy diet, and exercising regularly, as well as medications to manage symptoms and prevent further progression of the disease. In some cases, surgery or other medical procedures may be necessary to open or bypass blocked arteries.
In the medical field, "Atrial Function, Right" refers to the ability of the right atrium, one of the two upper chambers of the heart, to effectively contract and pump blood into the right ventricle. This process is an important part of the heart's overall function and helps to ensure that oxygen-rich blood is delivered to the lungs and oxygen-poor blood is returned to the heart to be pumped to the rest of the body. Atrial function can be assessed through various diagnostic tests, including echocardiography, which uses sound waves to create images of the heart. Abnormalities in right atrial function can be associated with a variety of cardiovascular conditions, including heart failure, atrial fibrillation, and valvular heart disease.
Iloprost is a medication used to treat a variety of medical conditions related to blood vessels, including pulmonary hypertension (high blood pressure in the arteries of the lungs), Raynaud's phenomenon (a condition that causes the fingers and toes to turn white or blue when exposed to cold), and chronic thromboembolic pulmonary hypertension (high blood pressure in the arteries of the lungs caused by blood clots). It works by relaxing and widening blood vessels, which can improve blood flow and reduce blood pressure. Iloprost is usually administered as a gas through a nebulizer or as a solution that is injected into a vein. It can cause side effects such as headache, nausea, and flushing.
In the medical field, "Animals, Newborn" typically refers to animals that are less than 28 days old. This age range is often used to describe the developmental stage of animals, particularly in the context of research or veterinary medicine. Newborn animals may require specialized care and attention, as they are often more vulnerable to illness and injury than older animals. They may also have unique nutritional and behavioral needs that must be addressed in order to promote their growth and development. In some cases, newborn animals may be used in medical research to study various biological processes, such as development, growth, and disease. However, the use of animals in research is highly regulated, and strict ethical guidelines must be followed to ensure the welfare and safety of the animals involved.
The basilar artery is a large blood vessel located at the base of the brain. It is one of the three main arteries that supplies blood to the brain, along with the internal carotid arteries and vertebral arteries. The basilar artery arises from the fusion of the two vertebral arteries and runs downward through the brainstem, where it branches into two smaller arteries called the pontine arteries. The basilar artery is a crucial blood supply to the brainstem and cerebellum, and any damage or blockage to this artery can have serious consequences for brain function.
Ischemia is a medical condition that occurs when there is a lack of blood flow to a particular part of the body. This can happen when the blood vessels that supply blood to the affected area become narrowed or blocked, either due to a physical obstruction or a decrease in blood pressure. Ischemia can affect any part of the body, but it is most commonly associated with the heart and brain. In the heart, ischemia can lead to a condition called angina, which is characterized by chest pain or discomfort. If the blood flow to the heart is completely blocked, it can result in a heart attack. In the brain, ischemia can cause a stroke, which can lead to permanent damage or even death if not treated promptly. Ischemia can also occur in other organs, such as the kidneys, limbs, and intestines, and can cause a range of symptoms depending on the affected area. Treatment for ischemia typically involves addressing the underlying cause of the blockage or narrowing of the blood vessels, such as through medication, surgery, or lifestyle changes.
Aneurysm, ruptured refers to a medical condition in which a weakened or bulging blood vessel in the brain or elsewhere in the body bursts or leaks, causing blood to leak out into the surrounding tissue. This can be a life-threatening emergency, as the leaked blood can cause damage to surrounding brain tissue, leading to brain swelling, bleeding, and potentially permanent brain damage or death. Ruptured aneurysms are often caused by high blood pressure, smoking, or a family history of aneurysms. Treatment typically involves surgery or endovascular coiling to repair or clip the ruptured aneurysm and prevent further bleeding.
Nitroglycerin is a powerful vasodilator medication that is used to treat angina pectoris (chest pain caused by reduced blood flow to the heart muscle) and to prevent heart attacks. It works by relaxing the smooth muscles in the blood vessels, particularly those that supply blood to the heart, which increases blood flow and reduces the workload on the heart. Nitroglycerin is usually administered as a sublingual tablet or spray, which is placed under the tongue or sprayed into the mouth. It is absorbed quickly into the bloodstream and begins to work within a few minutes. The effects of nitroglycerin are short-lived, lasting only a few minutes to an hour, and the medication must be taken as needed to relieve symptoms. While nitroglycerin is a highly effective medication for treating angina, it can cause side effects such as headache, dizziness, and low blood pressure. It is also contraindicated in patients with certain medical conditions, such as uncontrolled high blood pressure or severe heart failure.
In the medical field, altitude refers to the height above sea level at which a person or object is located. This can have significant effects on the body, particularly on the respiratory and cardiovascular systems. At higher altitudes, the air pressure is lower, which means there is less oxygen available to breathe. This can lead to altitude sickness, a condition characterized by symptoms such as headache, nausea, dizziness, and shortness of breath. In addition, the lower air pressure at high altitudes can put increased strain on the heart and lungs, which can be particularly problematic for people with pre-existing cardiovascular or respiratory conditions.
3',5'-Cyclic-GMP Phosphodiesterases (cGMP-PDEs) are a family of enzymes that play a crucial role in regulating the levels of cyclic guanosine monophosphate (cGMP) in the body. cGMP is a second messenger molecule that is involved in a wide range of cellular processes, including smooth muscle relaxation, neurotransmission, and immune cell function. cGMP-PDEs are responsible for breaking down cGMP into guanosine monophosphate (GMP), thereby terminating the signaling effects of cGMP. There are 11 different subtypes of cGMP-PDEs, each with different tissue distribution and substrate specificity. In the medical field, cGMP-PDEs are of particular interest because they are targeted by a class of drugs called phosphodiesterase inhibitors (PDE inhibitors). PDE inhibitors are used to treat a variety of conditions, including erectile dysfunction, pulmonary hypertension, and glaucoma. By inhibiting cGMP-PDEs, PDE inhibitors increase the levels of cGMP in the body, leading to the desired therapeutic effects.
Thiophenes are a class of organic compounds that contain a five-membered ring with one sulfur atom and two carbon atoms. They are commonly found in a variety of natural and synthetic compounds, including some pharmaceuticals and pesticides. In the medical field, thiophenes are sometimes used as ingredients in drugs to treat a variety of conditions. For example, some thiophene-containing drugs are used to treat high blood pressure, while others are used to treat depression and anxiety. Some thiophenes have also been studied for their potential use in treating cancer. It is important to note that thiophenes can have potential side effects, and their use in medicine is carefully regulated by regulatory agencies such as the U.S. Food and Drug Administration (FDA).
Kidney diseases refer to a wide range of medical conditions that affect the kidneys, which are two bean-shaped organs located in the back of the abdomen. The kidneys play a crucial role in filtering waste products from the blood and regulating the body's fluid balance, electrolyte levels, and blood pressure. Kidney diseases can be classified into two main categories: acute kidney injury (AKI) and chronic kidney disease (CKD). AKI is a sudden and severe decline in kidney function that can be caused by a variety of factors, including dehydration, infection, injury, or certain medications. CKD, on the other hand, is a progressive and chronic condition that develops over time and is characterized by a gradual decline in kidney function. Some common types of kidney diseases include glomerulonephritis, which is an inflammation of the glomeruli (the tiny blood vessels in the kidneys), polycystic kidney disease, which is a genetic disorder that causes cysts to form in the kidneys, and kidney stones, which are hard deposits that can form in the kidneys and cause pain and other symptoms. Treatment for kidney diseases depends on the underlying cause and severity of the condition. In some cases, lifestyle changes such as diet modification and exercise may be sufficient to manage the condition. In more severe cases, medications, dialysis, or kidney transplantation may be necessary. Early detection and treatment of kidney diseases are essential to prevent complications and improve outcomes.
Chloralose is a sedative-hypnotic drug that was widely used in the past as a general anesthetic and as a treatment for insomnia. It is a colorless, crystalline solid that is soluble in water and alcohol. Chloralose works by depressing the central nervous system, leading to a loss of consciousness and muscle relaxation. It was first synthesized in the late 19th century and was widely used until the 1950s, when it was replaced by safer and more effective anesthetics. Chloralose is still used today in some medical settings, but its use is limited due to its potential for toxicity and adverse side effects.
Cardiomegaly is a medical condition characterized by an enlarged heart. The term "cardiomegaly" comes from the Greek words "kardia," meaning heart, and "mega," meaning large. Cardiomegaly can be caused by a variety of factors, including hypertension, valvular heart disease, myocardial infarction (heart attack), cardiomyopathy (disease of the heart muscle), and certain genetic disorders. The diagnosis of cardiomegaly is typically made through imaging tests such as echocardiography, chest X-rays, or computed tomography (CT) scans. Cardiomegaly can lead to a variety of complications, including heart failure, arrhythmias, and increased risk of stroke. Treatment depends on the underlying cause of the cardiomegaly and may include medications, lifestyle changes, and in some cases, surgery.
Blood substitutes are substances that are designed to replace or supplement the function of blood in the human body. They are typically used in situations where there is a shortage of blood, such as during surgery or in cases of trauma, or when a patient's blood is not compatible with donated blood. Blood substitutes can be classified into two main categories: liquid and solid. Liquid blood substitutes are typically composed of artificial blood cells suspended in a solution, while solid blood substitutes are made up of artificial blood cells that have been encapsulated in a polymer matrix. There are several different types of blood substitutes that have been developed, including hemoglobin-based oxygen carriers (HBOCs), perfluorocarbon emulsions (PFCEs), and synthetic red blood cells (sRBCs). Each type of blood substitute has its own advantages and disadvantages, and their effectiveness and safety have been the subject of extensive research and clinical trials. Despite the development of various blood substitutes, there are still many challenges to overcome before they can be widely used in clinical practice. These include issues related to safety, efficacy, and cost, as well as regulatory hurdles and public acceptance.
Cardiomyopathy, restrictive is a type of heart disease that affects the heart's ability to pump blood effectively. In restrictive cardiomyopathy, the heart muscle becomes stiff and thickened, making it difficult for the heart to relax and fill with blood. This can lead to a decrease in the amount of blood that the heart is able to pump out to the rest of the body, which can cause symptoms such as shortness of breath, fatigue, and swelling in the legs and ankles. There are several different types of restrictive cardiomyopathy, including infiltrative cardiomyopathy, fibrotic cardiomyopathy, and endomyocardial fibrosis. The exact cause of restrictive cardiomyopathy is often unknown, but it can be caused by a variety of factors, including viral infections, exposure to toxins, and certain genetic conditions. Treatment for restrictive cardiomyopathy typically involves managing symptoms and addressing any underlying causes of the condition. In some cases, medications or surgery may be necessary to improve heart function and prevent complications.
Inulin is a type of dietary fiber that is found in many plant foods, including onions, garlic, leeks, asparagus, and chicory root. It is a polysaccharide made up of fructose molecules linked together, and it is not digested by human enzymes. In the medical field, inulin is often used as a prebiotic, which means that it helps to promote the growth of beneficial bacteria in the gut. This can have a number of potential health benefits, including improved digestion, reduced inflammation, and a lower risk of certain diseases, such as obesity, type 2 diabetes, and heart disease. Inulin is also sometimes used as a thickener or stabilizer in food products, such as ice cream, yogurt, and baked goods. It is generally considered safe for most people to consume, although some people may experience digestive symptoms, such as bloating or gas, when they eat foods that contain inulin.
Cardiogenic shock is a medical condition in which the heart is unable to pump enough blood to meet the body's needs. This can occur as a result of a heart attack, heart failure, or other conditions that affect the heart's ability to function properly. Symptoms of cardiogenic shock may include rapid or weak pulse, low blood pressure, confusion, and shortness of breath. Treatment typically involves medications to improve heart function and support organ function, as well as mechanical support such as a heart pump. In severe cases, surgery may be necessary to repair or replace the damaged heart tissue.
In the medical field, bandages are medical devices used to cover and protect wounds, injuries, or surgical incisions. They are typically made of absorbent materials such as gauze, cotton, or synthetic fibers, and may be wrapped around the affected area to provide support and compression. Bandages come in various shapes and sizes, and are often used in combination with other medical devices such as adhesive tape, dressings, and compression stockings. They are commonly used in hospitals, clinics, and first aid kits, and are an essential part of wound care. Bandages can be used for a variety of purposes, including: 1. Protecting wounds from infection 2. Providing support and compression to injured or swollen areas 3. Holding dressings in place 4. Providing temporary relief from pain or discomfort 5. Covering surgical incisions to promote healing and prevent infection It is important to choose the appropriate type of bandage for the specific wound or injury being treated, and to change the bandage regularly to ensure proper healing and prevent infection.
Myocardial ischemia is a medical condition that occurs when the blood flow to the heart muscle is reduced or blocked, leading to a lack of oxygen and nutrients to the heart cells. This can cause chest pain or discomfort, shortness of breath, and other symptoms. Myocardial ischemia is often caused by atherosclerosis, a condition in which plaque builds up in the arteries, narrowing or blocking the flow of blood. It can also be caused by other factors, such as heart valve problems or blood clots. Myocardial ischemia can be a serious condition and requires prompt medical attention to prevent heart attack or other complications.
Papaverine is a medication that is used to treat a variety of medical conditions, including erectile dysfunction, Raynaud's disease, and glaucoma. It is a vasodilator, which means that it helps to widen blood vessels and improve blood flow. Papaverine is usually administered intravenously or intramuscularly, and it can cause side effects such as headache, nausea, and dizziness. It is important to note that papaverine should only be used under the supervision of a healthcare professional.
Nitric oxide synthase type III (NOS3) is an enzyme that is primarily found in the endothelial cells of blood vessels. It is responsible for the production of nitric oxide (NO), a gas that plays a crucial role in regulating blood flow and blood pressure. NOS3 is activated by various stimuli, including shear stress, which is caused by the flow of blood through the blood vessels. When activated, NOS3 produces NO, which causes the smooth muscle cells in the blood vessels to relax, allowing blood to flow more easily. This helps to regulate blood pressure and maintain proper blood flow to the body's tissues. In addition to its role in regulating blood flow, NOS3 has been implicated in a number of other physiological processes, including the immune response, neurotransmission, and the development of certain diseases, such as atherosclerosis and hypertension. Disruptions in NOS3 function have been linked to a number of cardiovascular diseases, including heart attack, stroke, and peripheral artery disease. As a result, NOS3 is an important target for the development of new treatments for these conditions.
Fibrosis is a medical condition characterized by the excessive accumulation of fibrous connective tissue in the body. This tissue is made up of collagen fibers, which are responsible for providing strength and support to tissues. Fibrosis can occur in any part of the body, but it is most commonly seen in the lungs, liver, heart, and kidneys. It can be caused by a variety of factors, including injury, infection, inflammation, and chronic diseases such as diabetes and scleroderma. The accumulation of fibrous tissue can lead to a range of symptoms, depending on the affected organ. For example, in the lungs, fibrosis can cause shortness of breath, coughing, and chest pain. In the liver, it can lead to liver failure and other complications. In the heart, it can cause heart failure and arrhythmias. Fibrosis is often a progressive condition, meaning that it can worsen over time if left untreated. Treatment options depend on the underlying cause of the fibrosis and the severity of the symptoms. In some cases, medications or surgery may be used to slow the progression of the disease or to manage symptoms.
Biphenyl compounds are a class of organic compounds that consist of two benzene rings joined together by a single carbon-carbon bond. They are commonly used as industrial solvents, plasticizers, and flame retardants. In the medical field, biphenyl compounds have been studied for their potential therapeutic effects, including anti-inflammatory, anti-cancer, and anti-viral properties. Some biphenyl compounds have also been used as diagnostic agents in medical imaging. However, some biphenyl compounds have been associated with adverse health effects, including endocrine disruption, neurotoxicity, and carcinogenicity, and their use is regulated in many countries.
In the medical field, lactates refer to the byproducts of anaerobic metabolism in the body. Specifically, lactate is a type of organic acid that is produced when the body breaks down glucose in the absence of oxygen. This process, known as anaerobic glycolysis, occurs in muscle cells and other tissues when oxygen levels are low. Lactate levels in the blood can be measured using a blood test, and elevated levels of lactate can indicate a variety of medical conditions, including hypoxia (low oxygen levels in the body), sepsis (infection), and certain types of cancer. In addition, lactate is often used as a marker of exercise intensity, as it increases during physical activity. Overall, lactates play an important role in the body's metabolism and can provide valuable information to healthcare providers in the diagnosis and treatment of various medical conditions.
Bloodletting is an ancient medical practice that involves the removal of blood from a patient's body, typically through a cut or puncture, in the belief that it can help to balance the body's "humors" and treat a variety of illnesses and conditions. The practice was widely used in Western medicine for centuries, but its use declined in the 19th century with the development of more effective and humane medical treatments. Today, bloodletting is no longer considered a valid medical practice and is not used in modern medicine.
Respiratory alkalosis is a medical condition characterized by an increase in the pH of the blood, which occurs when the body produces too much carbon dioxide (CO2) and not enough bicarbonate ions (HCO3-) to buffer the excess CO2. This can occur due to various factors, including hyperventilation, which is an increase in the rate and depth of breathing, or the use of certain medications or drugs that can cause respiratory alkalosis. The body regulates the pH of the blood through a complex system involving the lungs, kidneys, and other organs. When the pH of the blood becomes too alkaline, it can cause a range of symptoms, including dizziness, tingling in the hands and feet, muscle cramps, and confusion. In severe cases, respiratory alkalosis can lead to seizures, coma, and even death. Treatment for respiratory alkalosis typically involves addressing the underlying cause, such as stopping the use of a medication that is causing hyperventilation or treating an underlying medical condition. In some cases, oxygen therapy may be used to help the body regulate its pH levels.
Methyl ethers are organic compounds that contain a methyl group (CH3) attached to an oxygen atom. They are a type of ether, which is a functional group consisting of an oxygen atom bonded to two alkyl or aryl groups. In the medical field, methyl ethers are used as anesthetic agents, particularly for induction of anesthesia. They are also used as solvents and as intermediates in the synthesis of other compounds. Some methyl ethers have been found to have potential medicinal properties, such as anti-inflammatory and analgesic effects. One example of a methyl ether used in medicine is methoxyflurane, which was once a common anesthetic but has been largely replaced by other agents due to its potential for toxicity and side effects. Other methyl ethers that have been studied for their potential medicinal properties include diisopropyl ether and tert-butyl methyl ether.
Myocardial reperfusion injury (MRI) refers to the damage that occurs to the heart muscle when blood flow is restored to an area of the heart that has been previously deprived of oxygen-rich blood. This can happen during a heart attack, when a blood clot blocks a coronary artery, cutting off blood flow to a portion of the heart muscle. MRI is a complex process that involves a combination of physical, chemical, and inflammatory mechanisms. When blood flow is restored to the heart muscle, it can cause damage to the cells and tissues in the area, leading to inflammation, cell death, and scarring. This damage can further impair the heart's ability to pump blood effectively, leading to heart failure and other complications. There are several strategies that can be used to reduce the risk of MRI, including the use of medications to prevent blood clots, timely revascularization procedures to restore blood flow to the heart muscle, and the use of protective therapies to minimize the damage caused by reperfusion. Understanding the mechanisms of MRI is important for developing effective treatments to prevent and manage heart attacks and other cardiovascular diseases.
Saralasin is a medication that is used to treat high blood pressure (hypertension). It is a type of drug called an angiotensin II receptor antagonist, which works by blocking the action of a hormone called angiotensin II in the body. Angiotensin II is a hormone that helps to regulate blood pressure by narrowing blood vessels and increasing the amount of fluid in the body. By blocking the action of angiotensin II, Saralasin helps to relax blood vessels and lower blood pressure. It is usually taken by mouth and is available in tablet form.
Creatinine is a waste product that is produced by the muscles in the body as a result of normal metabolism. It is filtered out of the blood by the kidneys and excreted in the urine. In the medical field, creatinine is often used as a marker of kidney function. A high level of creatinine in the blood can indicate that the kidneys are not functioning properly, while a low level can indicate that the kidneys are overworking. Creatinine levels can also be used to monitor the effectiveness of treatment for kidney disease.
Hypertrophy, Left Ventricular refers to the thickening of the left ventricle, which is the main pumping chamber of the heart. This thickening can occur due to an increase in the workload on the heart, such as high blood pressure or a condition called aortic stenosis, or due to an underlying genetic disorder. Left ventricular hypertrophy can lead to heart failure, arrhythmias, and an increased risk of heart attack. It is typically diagnosed through an echocardiogram, a test that uses sound waves to create images of the heart. Treatment may include medications to lower blood pressure and reduce workload on the heart, as well as lifestyle changes such as exercise and a healthy diet. In severe cases, surgery may be necessary.
Pentazocine is a synthetic opioid pain medication that is used to treat moderate to severe pain. It is a centrally acting analgesic that works by binding to opioid receptors in the brain and spinal cord, which reduces the perception of pain and produces feelings of euphoria. Pentazocine is available in both immediate-release and extended-release forms, and it is typically prescribed for short-term use only. It is often used to treat postoperative pain, as well as pain associated with chronic conditions such as cancer, arthritis, and fibromyalgia. Pentazocine can cause side effects such as dizziness, nausea, constipation, and respiratory depression. It can also be habit-forming and may lead to addiction if used for an extended period of time. As such, it is typically only prescribed to patients who have not responded to other pain medications or who cannot tolerate the side effects of other opioids.
Aortic Valve Insufficiency (AVI) is a medical condition in which the aortic valve fails to close properly, allowing blood to flow back into the left ventricle of the heart. This can lead to a decrease in the amount of blood that is pumped out of the heart with each beat, which can cause symptoms such as shortness of breath, fatigue, and chest pain. AVI can be caused by a variety of factors, including damage to the valve from infection, high blood pressure, or aging. It can also be caused by certain medical conditions, such as rheumatic fever or Marfan syndrome. Treatment for AVI may include medications, lifestyle changes, or surgery, depending on the severity of the condition.
Chlorothiazide is a medication that belongs to a class of drugs called thiazide diuretics. It is primarily used to treat high blood pressure (hypertension) by reducing the amount of salt and water that the body retains. Chlorothiazide can also be used to treat swelling (edema) caused by conditions such as heart failure, liver disease, or kidney disease. Chlorothiazide works by blocking the reabsorption of sodium and chloride ions in the kidneys, which leads to an increase in urine output and a reduction in blood volume. This, in turn, helps to lower blood pressure and reduce swelling. Chlorothiazide is available in tablet form and is usually taken once or twice a day, depending on the individual's needs and the condition being treated. It is important to follow the dosage instructions provided by your healthcare provider and to take the medication at the same time(s) each day to maintain consistent blood pressure control. Common side effects of chlorothiazide include dizziness, headache, nausea, and loss of appetite. More serious side effects may include low blood pressure, electrolyte imbalances, and allergic reactions. It is important to discuss any potential side effects with your healthcare provider before starting treatment with chlorothiazide.
The common carotid artery is a large artery in the neck that supplies oxygenated blood to the head and neck. It is one of the two main arteries that arise from the aortic arch, the other being the brachiocephalic artery. The common carotid artery begins at the base of the neck, just below the thyroid gland, and travels up the neck on the side of the neck towards the head. It then divides into the internal and external carotid arteries, which supply blood to different parts of the head and neck. The common carotid artery is an important blood vessel, and any problems with it can lead to serious health issues, such as stroke or heart attack.
Adrenergic beta-agonists are a class of drugs that mimic the effects of adrenaline (epinephrine) on the body. They work by binding to beta-adrenergic receptors, which are found on the surface of cells in various organs and tissues throughout the body, including the heart, lungs, and blood vessels. When adrenergic beta-agonists bind to these receptors, they stimulate the production of cyclic AMP (cAMP), which triggers a cascade of chemical reactions that ultimately leads to the relaxation of smooth muscle cells in the walls of blood vessels, bronchial tubes, and other organs. This results in dilation of blood vessels, bronchodilation, and increased heart rate and contractility. Adrenergic beta-agonists are used to treat a variety of medical conditions, including asthma, chronic obstructive pulmonary disease (COPD), heart failure, and certain types of arrhythmias. They are also used to treat acute bronchospasm, such as that caused by exercise or allergens, and to treat low blood pressure in patients who have undergone surgery or who are experiencing shock. Examples of adrenergic beta-agonists include albuterol, salbutamol, and terbutaline. These drugs are available in a variety of forms, including inhalers, tablets, and injectables.
Catecholamines are a group of neurotransmitters that are produced by the adrenal glands and certain neurons in the brain. They include norepinephrine (also known as noradrenaline), epinephrine (also known as adrenaline), and dopamine. Catecholamines play a crucial role in the body's "fight or flight" response, which is triggered in response to stress or danger. They are released by the adrenal glands in response to stress, and by certain neurons in the brain in response to certain stimuli. Norepinephrine and epinephrine are primarily responsible for the physical effects of the fight or flight response, such as increased heart rate, blood pressure, and respiration. Dopamine, on the other hand, is primarily responsible for the psychological effects of the response, such as increased alertness and focus. Catecholamines are also involved in a number of other physiological processes, including the regulation of blood sugar levels, the control of blood vessel diameter, and the regulation of mood and motivation. They are often used as medications to treat a variety of conditions, including hypertension, heart disease, and depression.
Adrenergic beta-antagonists are a class of drugs that block the action of adrenaline (epinephrine) and noradrenaline (norepinephrine) on beta-adrenergic receptors in the body. These receptors are found in various organs and tissues, including the heart, lungs, and blood vessels. When adrenaline and noradrenaline bind to beta-adrenergic receptors, they cause a number of physiological responses, such as increased heart rate, blood pressure, and bronchodilation. Adrenergic beta-antagonists work by blocking these receptors, thereby reducing the effects of adrenaline and noradrenaline. Adrenergic beta-antagonists are used to treat a variety of medical conditions, including high blood pressure, angina pectoris (chest pain), heart failure, and arrhythmias. They are also used to prevent migraines and to treat anxiety and panic disorders. Some common examples of adrenergic beta-antagonists include propranolol, atenolol, and metoprolol.
Receptors, Vasopressin are proteins found on the surface of cells in the body that bind to and respond to the hormone vasopressin. Vasopressin is produced by the hypothalamus and released by the posterior pituitary gland. It plays a role in regulating water balance in the body by constricting blood vessels and increasing the reabsorption of water in the kidneys. Vasopressin receptors are also found in other parts of the body, including the brain, heart, and blood vessels, where they can have a variety of effects, including regulating blood pressure and promoting the growth of blood vessels.
Hemodynamics
Hemodynamics of the aorta
Moens-Korteweg equation
Pulse wave velocity
History of continuous noninvasive arterial pressure
Rajat Mittal
Carotid sinus
Frenzel maneuver
Vascular remodelling in the embryo
Rheology
Paolo Zamboni
Great saphenous vein
Ultrasonography of chronic venous insufficiency of the legs
Erythrocyte deformability
Magdy Younes
Anterior accessory saphenous vein
Hemorheology
Erythrocyte aggregation
Joshua B. Bederson
Visual impairment due to intracranial pressure
Valsalva maneuver
Diallyl trisulfide
Venous return
Ductus venosus
Acute cardiac unloading
Hypoxia (medical)
Physiology of underwater diving
George Stouffer
Harvey Feigenbaum
Kawasaki disease
Synonyms of hemodynamics | FactMonster
Gravitational haemodynamics and oedema prevention in the giraffe | Nature
PDF) Hemodynamics in Idealized Stented Coronary Arteries: Important Stent Design Considerations
Sleep-related O2 desaturation and daytime pulmonary haemodynamics in COPD patients with mild hypoxaemia | European Respiratory...
A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a...
Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a...
5.1 The Role of Blood Pressure, Aortic Stiffness, and Haemodynamics in Brain Health in Older People with Type 2 Diabetes...
Internet Medical Journal: Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise.
Formats: Text / Subjects: Hemodynamics / Languages: English / Copyright: Public domain - Digital Collections - National Library...
Intracranial hemodynamics during intravenous infusion of glyceryl trinitrate - Result
Hemodynamics - Online supplement
measurement of hemodynamics - CardioVillage
Cardiosurgery & Hemodynamics - Spitali Salus
The central hemodynamics assessment methods in thyrotoxicosis patients under inhaled anesthesia
| ScienceRise: Medical...
Order our book now! - Maternal Hemodynamics
General Approach to the Trauma Patient: Overview, Initial Evaluation and Treatment, Physical Examination
Haemodynamics for anaesthetists (AN33)
DailyMed - DILTIAZEM HYDROCHLORIDE injection
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury. - Nuffield Department of Clinical Neurosciences
Plus it
Interrupting Prolonged Sitting and Endothelial Function in P... : Medicine & Science in Sports & Exercise
Regulation of Renal Hemodyamics by Purinergic Receptors in Angiotensin II -Induced Hypertension | IntechOpen
Treatment with oral treprostinil improves hemodynamics in participants with PAH
Integrated Electronics for Deep Implants to Remotely Monitor Hemodynamics - EPFL
Podcast- Ellen T. Roche, PHD- #MIT #massachusettsinstituteoftechnology # CardiacPhysiology #Hemodynamics #HeartFailur...
Maternal hemodynamics at 11-13 weeks' gestation and risk of pre-eclampsia.
Hemodynamics of artificial devices used in extracorporeal life support | SCI internal pages
ECLS-SHOCK trial investigated the effect of early extracorp | Hemodynamics Management | ICU REACH
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine |...
Improves hemodynamics1
- Intentionally fracturing the stent frame permits further expansion of the surgical valve and improves hemodynamics. (medscape.com)
Aortic5
- Type 2 diabetes (T2D) is associated with dementia, and abnormal blood pressure (BP), aortic stiffness, and haemodynamics. (atlantis-press.com)
- Measurements included neuropsychological battery, brain MRI, and Mobil-o-Graph-derived (IEM, Germany) aortic BP and haemodynamics. (atlantis-press.com)
- BP, aortic stiffness and altered haemodynamics contribute to early cognitive change and loss of white matter integrity in T2D. (atlantis-press.com)
- In terms of hemodynamics, aortic valve area at discharge increased significantly with BVF vs without (1.6 vs 1.4 cm 2 ), starting from 0.8 cm 2 at baseline in both groups. (medscape.com)
- In patients with a bicuspid aortic valve (BAV), these degenerative changes occur at an earlier age as a consequence of the abnormal hemodynamics across the valve leaflets. (medscape.com)
Humans1
- This 'neuroprosthetic baroreflex' controlled haemodynamics for extended periods of time in rodents, non-human primates and humans, after both acute and chronic SCI. (ox.ac.uk)
Invasive2
- To assess the central hemodynamics using calculation forms and invasive-noninvasive systems on the background of using inhaled minimal-streaming anesthesia at thyroidectomies in patients with thyrotoxicosis. (uran.ua)
- Kapur NK, Sorajja P. Invasive hemodynamics. (medlineplus.gov)
Physiology1
- In this video Ellen discusses the Device-Based Solutions to Improve Cardiac Physiology and Hemodynamics in Heart Failure With Preserved Ejection Fraction. (cardiologytalk.com)
Plasma2
- Plasma samples and hemodynamics were collected from PAH patients during right heart catheterizations at diagnosis (n = 48) and early follow-up, after treatment initiation (n = 33). (lu.se)
- Plasma levels of 14 ECM-related proteins, with altered levels in PAH compared to healthy controls, were analyzed with proximity extension assays, and related to hemodynamics, transplant-free survival time, and ESC/ERS risk score. (lu.se)
Patients2
- Changes in ocular hemodynamics in patients recovered from COVID-19]. (bvsalud.org)
- Compte tenu du nombre croissant d'infections et de décès par le virus de la grippe pandémique (H1N1) 2009 confirmés en laboratoire dans la Région OMS de la Méditerranée orientale, le Bureau régional a convoqué une réunion consultative d'experts impliqués dans la prise en charge clinique de patients infectés par ce virus. (who.int)
Study4
- The study of the blood flow is called hemodynamics, and the study of the properties of the blood flow is called hemorheology. (wikipedia.org)
- A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study. (iasp-pain.org)
- Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study. (insa-lyon.fr)
- All participants were using one approved PAH therapy at study entry, and some (n=61) consented for a hemodynamics sub-study with right-heart catheterization at Baseline and Week 24. (pvrinstitute.org)
Flow3
- Hemodynamics or haemodynamics are the dynamics of blood flow. (wikipedia.org)
- Hemodynamics explains the physical laws that govern the flow of blood in the blood vessels. (wikipedia.org)
- Local hemodynamics worsened with luminal protrusion of the stent and with stent malapposition, adverse high WSS and WSSG were identified around peak flow and throughout the cardiac cycle respectively. (researchgate.net)
Blood1
- Because blood vessels are not rigid tubes, classic hydrodynamics and fluids mechanics based on the use of classical viscometers are not capable of explaining haemodynamics. (wikipedia.org)
Time1
- Since the Hemodynamics ReelCardio V-Patch is a real time, AECG monitoring system, we can offer real time ECG analysis on a 24 hour - 30 day basis. (hemodynamics.co)
Risk1
- Internet Medical Journal: Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise. (medjournal.com)
Type1
- Do Sodium-Glucose Cotransporter-2 Inhibitors Affect Renal Hemodynamics by Different Mechanisms in Type 1 and Type 2 Diabetes? (cdc.gov)
Cerebral8
- Factors other than elevated levels of ammonia may be implicated in hepatic encephalopathy (HE) pathophysiology, including abnormal cerebral haemodynamics. (nih.gov)
- The aim of this study was to evaluate cerebral haemodynamics by TCD in patients with compensated and decompensated cirrhosis, and patients with and without HE. (nih.gov)
- These results indicate that cerebral haemodynamics are altered in patients with cirrhosis, in relation to severity of disease and HE. (nih.gov)
- This study evaluates the efficacy and tolerance of a 24-week treatment with 250 mg/d ACZ, which could be chronically implemented to improve cerebral hemodynamics in CADASIL. (nih.gov)
- In this feasibility study, we evaluated the utility of functional near infrared spectroscopy (fNIRS) in measuring cerebral hemodynamics in the prefrontal cortex (PFC) in toddlers between 18 and 36 months of age. (nih.gov)
- We studied cerebral blood flow (CBF), oxygen extraction fraction (OEF), transit time (TT) and hemodynamic reserve capacity using acetazolamide (ACZ) in both the pre- and postoperative states, and evaluated the effect of surgery on the cerebral hemodynamics. (elsevierpure.com)
- Conclusion: PET can demonstrate significant cerebral hemodynamic change after surgery, especially in CBF measurement 5 min after intravenous ACZ, and may therefore be useful for evaluating cerebral hemodynamics pre- and postsurgery. (elsevierpure.com)
- Application of Deep Learning in the Identification of Cerebral Hemodynamics Data Obtained from Functional Near-Infrared Spectroscopy: A Preliminary Study of Pre- and Post-Tooth Clenching Assessment. (bvsalud.org)
Hypertension2
Methods1
- In this context, this work aims to analyze the impact of stent design and stent overlapping on patient-specific SFA hemodynamics.Methods: Through a morphing technique, single or multiple stents were virtually implanted within two patient specific, post-operative SFA models reconstructed from computed tomography. (polito.it)
Arterial1
- A Millar catheter (1.4-Fr) was inserted through the carotid artery and advanced retrograde toward the center and in to the still left ventricle (LV) to measure in vivo arterial and myocardial hemodynamics. (stemcellresearchformichigan.com)
Ventricle1
- Hemodynamics the singular ventricle is a major research topic in cardiology and there exists a relationship between fluid dynamical features and cardiac behavior in health and disease. (biorxiv.org)
Functional1
- We hypothesized that 3 months of sildenafil (50 mg orally every 8 hours) added to standard treatment would be safe and improve functional capacity and hemodynamics in PAH patients. (nih.gov)
Subject1
- Two operators performed hemodynamics measurements on each subject in supine, sitting, semirecumbent, passive leg raising (PLR) 20°, and PLR 60° positions using both aortic and pulmonary approaches. (hku.hk)
Order1
- The overlapping length, rather than the order of stent implantation, highly and negatively impacted the hemodynamics.Conclusion: The proposed computational workflow compared different SFA stent designs and stent overlapping configurations, highlighting those providing the most favorable hemodynamic conditions. (polito.it)
Effects2
- To investigate the effects of hemodynamics on Kaiso function, we utilized a novel in vitro system to apply physiologically determined shear stresses from a human common carotid artery (atheroprotective) or internal carotid sinus (atheroprone) to primary human endothelial cell (EC) monolayers. (virginia.edu)
- The microarrays demonstrated involvement of Kaiso in a variety of relevant signaling pathways and suggested an elevated importance of Kaiso in mediating the downstream effects of atheroprotective hemodynamics. (virginia.edu)