Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
Substances that are used in place of blood, for example, as an alternative to BLOOD TRANSFUSIONS after blood loss to restore BLOOD VOLUME and oxygen-carrying capacity to the blood circulation, or to perfuse isolated organs.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.
Puncture of a vein to draw blood for therapeutic purposes. Bloodletting therapy has been used in Talmudic and Indian medicine since the medieval time, and was still practiced widely in the 18th and 19th centuries. Its modern counterpart is PHLEBOTOMY.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
Solutions having the same osmotic pressure as blood serum, or another solution with which they are compared. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.
Volume of PLASMA in the circulation. It is usually measured by INDICATOR DILUTION TECHNIQUES.
Method for determining the circulating blood volume by introducing a known quantity of foreign substance into the blood and determining its concentration some minutes later when thorough mixing has occurred. From these two values the blood volume can be calculated by dividing the quantity of injected material by its concentration in the blood at the time of uniform mixing. Generally expressed as cubic centimeters or liters per kilogram of body weight.
Volume of circulating ERYTHROCYTES . It is usually measured by RADIOISOTOPE DILUTION TECHNIQUE.
Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed)
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The deformation and flow behavior of BLOOD and its elements i.e., PLASMA; ERYTHROCYTES; WHITE BLOOD CELLS; and BLOOD PLATELETS.
An abnormally low volume of blood circulating through the body. It may result in hypovolemic shock (see SHOCK).
Loss of blood during a surgical procedure.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Measurement of oxygen and carbon dioxide in the blood.
Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.
Procedure in which arterial blood pressure is intentionally reduced in order to control blood loss during surgery. This procedure is performed either pharmacologically or by pre-surgical removal of blood.
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Surgery performed on the heart.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
Recovery of blood lost from surgical procedures for reuse by the same patient in AUTOLOGOUS BLOOD TRANSFUSIONS. It is collected during (intraoperatively) or after completion of (postoperatively) the surgical procedures.
Blockage of the RETINAL VEIN. Those at high risk for this condition include patients with HYPERTENSION; DIABETES MELLITUS; ATHEROSCLEROSIS; and other CARDIOVASCULAR DISEASES.
Central retinal vein and its tributaries. It runs a short course within the optic nerve and then leaves and empties into the superior ophthalmic vein or cavernous sinus.
The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.
Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.
Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.

Effect of acute normovolemic hemodilution on distribution of blood flow and tissue oxygenation in dog skeletal muscle. (1/325)

Acute normovolemic hemodilution (ANH) is efficient in reducing allogenic blood transfusion needs during elective surgery. Tissue oxygenation is maintained by increased cardiac output and oxygen extraction and, presumably, a more homogeneous tissue perfusion. The aim of this study was to investigate blood flow distribution and oxygenation of skeletal muscle. ANH from hematocrit of 36 +/- 3 to 20 +/- 1% was performed in 22 splenectomized, anesthetized beagles (17 analyzed) ventilated with room air. Normovolemia was confirmed by measurement of blood volume. Distribution of perfusion within skeletal muscle was determined by using radioactive microspheres. Tissue oxygen partial pressure was assessed with a polarographic platinum surface electrode. Cardiac index (3.69 +/- 0.79 vs. 4.79 +/- 0.73 l. min-1. m-2) and muscle perfusion (4.07 +/- 0.44 vs. 5.18 +/- 0.36 ml. 100 g-1. min-1) were increased at hematocrit of 20%. Oxygen delivery to skeletal muscle was reduced to 74% of baseline values (0.64 +/- 0.06 vs. 0.48 +/- 0.03 ml O2. 100 g-1. min-1). Nevertheless, tissue PO2 was preserved (27.4 +/- 1.3 vs. 29.9 +/- 1. 4 Torr). Heterogeneity of muscle perfusion (relative dispersion) was reduced after ANH (20.0 +/- 2.2 vs. 13.9 +/- 1.5%). We conclude that a more homogeneous distribution of perfusion is one mechanism for the preservation of tissue oxygenation after moderate ANH, despite reduced oxygen delivery.  (+info)

Hemodilution, cerebral O2 delivery, and cerebral blood flow: a study using hyperbaric oxygenation. (2/325)

Hemodilution reduces blood viscosity and O2 content (CaO2) and increases cerebral blood flow (CBF). Viscosity and CaO2 may contribute to increasing CBF after hemodilution. However, because hematocrit is the major contributor to blood viscosity and CaO2, it has been difficult to assess their relative importance. By varying blood viscosity without changing CaO2, prior investigation in hemodiluted animals has suggested that both factors play roughly equal roles. To further investigate the relationship of hemodilution, blood viscosity, CaO2, and CBF, we took the opposite approach in hemodiluted animals, i.e., we varied CaO2 without changing blood viscosity. Hyperbaric O2 was used to restore CaO2 to normal after hemodilution. Pentobarbital sodium-anesthetized rats underwent isovolumic hemodilution with 6% hetastarch, and forebrain CBF was measured with [3H]nicotine. One group of animals did not undergo hemodilution and served as controls (Con). In the three experimental groups, hematocrit was reduced from 44% to 17-19%. Con and hemodiluted (HDil) groups were ventilated with 40% O2 at 101 kPa (1 atmosphere absolute), which resulted in CaO2 values of 19.7 +/- 1.3 and 8.1 +/- 0.7 (SD) ml O2/dl, respectively. A second group of hemodiluted animals (HBar) was ventilated with 100% O2 at 506 kPa (5 atmospheres absolute) in a hyperbaric chamber, which restored CaO2 to an estimated 18.5 +/- 0.5 ml O2/dl by increasing dissolved O2. A fourth group of hemodiluted animals (HCon) served as hyperbaric controls and were ventilated with 10% O2 at 506 kPa, resulting in CaO2 of 9.1 +/- 0.6 ml O2/dl. CBF was 79 +/- 19 ml. 100 g-1. min-1 in the Con group and significantly increased to 123 +/- 9 ml. 100 g-1. min-1 in the HDil group. When CaO2 was restored to baseline with dissolved O2 in the HBar group, CBF decreased to 104 +/- 20 ml. 100 g-1. min-1. When normoxia was maintained during hyperbaric exposure in the HCon group, CBF was 125 +/- 18 ml. 100 g-1. min-1, a value indistinguishable from that in normobaric HDil animals. Our data demonstrate that the reduction in CaO2 after hemodilution is responsible for 40-60% of the increase in CBF.  (+info)

Extreme, progressive isovolemic hemodilution with 5% human albumin, PentaLyte, or Hextend does not cause hepatic ischemia or histologic injury in rabbits. (3/325)

BACKGROUND: Physicians and their patients are greatly concerned about perioperative blood administration. Although isovolemic hemodilution is utilized to decrease the incidence of transfusion, it is unclear at what degree of hemodilution hepatoenteric ischemia and injury occurs. The authors hypothesized that hepatic ischemia, systemic ischemia, and tissue injury would occur during hemodilution in rabbits, and that the severity of ischemia and injury may be dependent on the fluid administered. METHODS: Rabbits anesthetized with isoflurane were assigned randomly to a sham-operated group (n = 8) or groups that underwent four isovolemic hemodilutions (25% of the blood volume removed at hourly intervals), with blood replaced with one of three solutions: balanced electrolyte solutions containing 6% pentastarch (n = 8), 6% hetastarch (n = 9), or 5% human albumin in normal saline (n = 8). Arterial ketone body ratio and plasma lactate, respectively, served as measures of hepatic and systemic ischemia. Gastric, duodenal, and hepatic histologic injury was assessed post mortem. RESULTS: Hemodilution from a baseline hematocrit of about 33% to about 8% (third hemodilution) with all three colloids did not result in a significant increase in plasma lactate concentration or decrease in arterial ketone body ratio. At a hematocrit of about 5% (fourth hemodilution), the hetastarch group had a significantly (P < 0.05) greater plasma lactate concentration than the sham-operated and 5% human albumin groups. There were no significant differences in arterial ketone body ratio or histologic injury between the groups. CONCLUSIONS: Isovolemic hemodilution (approximately 5% hematocrit) with albumin, pentastarch, or hetastarch solutions does not result in significant hepatic ischemia or injury assessed by histology.  (+info)

Effect of 20% in vitro haemodilution with warmed buffered salt solution and cerebrospinal fluid on coagulation. (4/325)

We have conducted an in vitro coagulation study consisting of two separate groups of 20 subjects using the thrombelastograph. In the first group, haemodilution was performed with a physiological balanced salt solution similar to plasma, with the exception of calcium, and buffered to a normal pH (Plasmalyte B) at 37 degrees C on blood obtained from consenting volunteers. In the second group, a protein-poor body fluid (cerebrospinal fluid (CSF)) obtained from parturient patients undergoing spinal anaesthesia for Caesarean section was used as the diluent. There were statistically significant differences between the warmed Plasmalyte B treated samples and their untreated controls for all variables measured by the thrombelastograph, except for maximum amplitude, and between the CSF treated samples and their untreated controls for all variables. We conclude that electrolyte and acid-base composition of the diluent fluid had no effect on the observation that crystalloid haemodilution produces hypercoagulability. The marked increase in coagulability produced by addition of CSF cannot be explained on a simple haemodilution basis and confirms previous suggestions of the presence of a procoagulant factor in CSF.  (+info)

Repetitive hemodilution in chronic obstructive pulmonary disease and pulmonary hypertension: effects on pulmonary hemodynamics, gas exchange, and exercise capacity. (5/325)

BACKGROUND: In cor pulmonale associated with severe chronic obstructive pulmonary disease (COPD), disturbances of pulmonary microcirculation may contribute significantly to hypoxemia, pulmonary hypertension, and exercise intolerance. OBJECTIVE: It was tested whether reduction of blood viscosity induced by repetitive hemodilution might improve pulmonary hemodynamics and oxygen uptake. METHODS: Seven patients with stable COPD (forced expiratory volume in 1 s 33 +/- 3 % of predicted, means +/- SE) and pulmonary hypertension were phlebotomized 5-6 times over a period of 3 months with substitution of 6% hydroxyethyl starch (molecular weight 40, 000). This resulted in a stepwise reduction of the hematocrit from 53.3 +/- 2.6 to 45.8 +/- 3.1% and a reduction of whole blood viscosity from 9.8 +/- 0.6 to 8.8 +/- 0.7 mPa x s at a shear rate of 2.0 s-1. Before and after the treatment period, patients underwent cardiopulmonary exercise testing and right heart catheterization. RESULTS: Mean pulmonary artery pressure (PAm) decreased from 30 +/- 3 to 22 +/- 2 mm Hg and arterial oxygen partial pressure (PaO2) increased from 63.2 +/- 2.2 to 71.8 +/- 3.7 mm Hg at rest. During peak exercise, PAm decreased from 59 +/- 7 to 53 +/- 7 mm Hg and PaO2 increased from 54.0 +/- 5.7 to 63.2 +/- 2.4 mm Hg after hemodilution. Peak oxygen consumption rose from 573 +/- 84 to 750 +/- 59 ml x min-1, corresponding to an increase in cardiac index from 4.25 +/- 0.5 to 5.88 +/- 0.76 liters x min-1 x m-2. Pulmonary vascular resistance fell from 345 +/- 53 to 194 +/- 32 dyn x s x cm-5. The patients' peak exercise capacity increased from 9.2 +/- 2. 0 before to 13.5 +/- 3.2 kJ at the end of the study (p < 0.05 for all differences, paired t test). CONCLUSION: The findings suggest that a prolonged improvement of pulmonary microcirculation by reducing blood viscosity may improve pulmonary gas exchange, central hemodynamics, and exercise tolerance in patients with severe COPD and pulmonary hypertension.  (+info)

Acute normovolaemic haemodilution vs controlled hypotension for reducing the use of allogeneic blood in patients undergoing radical prostatectomy. (6/325)

Blood loss in patients undergoing radical prostatectomy may be substantial. In a randomized, prospective study, we assessed two methods of reducing the need for allogeneic blood transfusion with regard to efficacy and costs. Sixty patients undergoing retropubic radical prostatectomy were allocated randomly to one of three groups. In group 1 (n = 20), acute normovolaemic haemodilution (ANH) was initiated after induction of anaesthesia; autologous blood 15 ml kg-1 was withdrawn and replaced by colloid solutions (gelatin) to maintain haemodynamic stability. In group 2 (n = 20), controlled hypotension was established using sodium nitroprusside (target mean arterial pressure (MAP) approximately 50 mm Hg). Group 3 (n = 20), without manipulations, served as a control group. Troponin T (TnT), a sensitive marker for myocardial ischaemia, and various coagulation variables were measured in the perioperative period. Packed red blood cells (PRBC) were given when haemoglobin concentration was less than 7 g dl-1. Cost calculations did not include hospital overhead costs or staff costs. In the ANH group, mean 1278 (SD 150) ml of autologous blood were withdrawn. Significantly more volume was infused in the ANH patients (gelatin 2450 (550) ml) than in the two other groups. Coagulation data (platelet count, activated partial thromboplastin time (aPTT), fibrinogen, antithrombin III (AT III), D-dimers) did not differ significantly between the three groups. The hypotension group had significantly lower blood loss (1260 (570) ml), whereas the ANH (1820 (680) ml) and control group (1920 (590) ml) did not differ significantly. Patients in the hypotension group needed significantly less PRBC (total 14 units; 75% of patients did not need PRBC) than the ANH (total 21 units; 55% of patients did not need PRBC) or control patients (total 28 units; 40% of patients did not need PRBC). Total costs were lowest in the hypotension group (41% less than in the control patients) (P < 0.05). We conclude that the use of hypotension during radical prostatectomy resulted in approximately 40% reduction in total transfusion costs. ANH was less effective and more costly than controlled hypotension.  (+info)

Pulse oximetry plethysmographic waveform during changes in blood volume. (7/325)

Systolic pressure variation (SPV) and its dDown component have been shown to be sensitive factors in estimating intravascular volume in patients undergoing mechanical ventilation. In this study, ventilation-induced changes in pulse oximeter plethysmographic waveform were evaluated after removal and after reinfusion of 10% estimated blood volume. The plethysmographic waveform variation (SPVplet) was measured as the difference between maximal and minimal peaks of waveform during the ventilatory cycle, and expressed as a percentage of the signal amplitude during apnoea. dUp(plet) and dDown(plet) were measured as the distance between the apnoeic plateau and the maximal or minimal plethysmographic systolic waveform, respectively. Intravascular volume was changed by removal of 10% of estimated blood volume and followed by equal volume replacement with Haemaccel. A 10% decrease in blood volume increased SPVplet from mean 17.0 (SD 11.8)% to 31.6 (28.0)% (P = 0.005) and dDown(plet) from 8.7 (5.1)% to 20.5 (12.9)% (P = 0.0005) compared with baseline. Changes in plethysmographic waveform correlated with changes in arterial SPV and dDown (r = 0.85; P = 0.0009). In the absence of invasive arterial pressure monitoring, ventilation-induced waveform variability of the plethysmographic signal measured from pulse oximetry is a useful tool in the detection of mild hypovolaemia.  (+info)

Cerebral response to haemodilution during cardiopulmonary bypass in dogs: the role of nitric oxide synthase. (8/325)

During cardiopulmonary bypass, haemodilution is standard practice and is accompanied by increases in cerebral blood flow (CBF). We investigated if changes in cerebral vascular resistance (CVR) during cardiopulmonary bypass-haemodilution are dependent on nitric oxide synthase. The cerebral response to haemodilution in nine dogs treated with the nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME), was compared with a control group (n = 8). Both groups underwent serial isovolaemic haemodilution (target packed cell volumes 0.39, 0.26, 0.19 and 0.14) using 6% dextran 70. CBF, CVR and cerebral metabolic rate for oxygen (CMRO2) were measured. While initial CVR was different in the two groups, haemodilution-dependent reductions in CVR were equivalent and the curves describing the packed cell volume-CVR relationship were parallel in control and nitric oxide synthase inhibition groups. Our data indicate that nitric oxide synthase does not play a primary role in the cerebral response to haemodilution.  (+info)

TY - JOUR. T1 - Responsiveness of stroke volume variation and central venous pressure during acute normovolemic and hypervolemic hemodilution. AU - Ji, Fu Hai. AU - Li, Wen Jing. AU - Li, Jiang. AU - Peng, Ke. AU - Yang, Jian Ping. AU - Liu, Hong. PY - 2013/5/20. Y1 - 2013/5/20. N2 - Background Stroke volume variation (SVV) is a robust indicator of fluid responsiveness during volume change. We compared the sensibility of SVV by Vigileo/Flotrac to central venous pressure (CVP) when volume changes in patients undergoing intraoperative acute normovolemic hemodilution (ANH) and acute hypervolemic hemodilution (AHH). Methods Forty patients were randomly divided into an ANH group (n=20) and an AHH group (n=20). All patients received general anesthesia and were mechanically ventilated. Data were collected from 7 different time-points in the ANH group: baseline, after withdrawal of 5%, 10%, and 15% of the estimated blood volume (EBV) and after replacement with an equal volume of 6% hydroxyethyl starch ...
In the acute normovolemic hemodilution group, intraoperative blood collection was performed to a target hemoglobin of 8.0 g/dL. Low central venous pressure anesthetic technique was used intraoperatively for both groups. A standardized transfusion protocol was applied to all patients intraoperatively and throughout the hospital stay.. The researchers randomized 63 patients to acute normovolemic hemodilution, and 67 to standard anesthetic management from 2004 to 2007.. Demographics, diagnoses, liver function, extent of resection, intraoperative blood loss, operative time, incidence and grade of complications, and length of hospital stay were similar between the 2 groups. The team found that acute normovolemic hemodilution reduced the overall allogeneic red cell transfusion rate by 50% compared with standard anesthetic management. Acute normovolemic hemodilution patients were less often transfused intraoperatively compared with the standard anesthetic management group.. The research team noted that ...
Children undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at high risk of being exposed to relatively large volumes of allogeneic blood products. If blood transfusion can be life-saving in some circumstances (e.g. major haemodilution or massive haemorrhage), the administration of large volumes of allogeneic blood products has been shown to significantly increase the risk of postoperative complications. Over the last decades, different strategies have been developed to reduce the need for blood product transfusions.. Acute normovolemic hemodilution (ANH) has been used for a long time in adults undergoing high bleeding risk procedures, including cardiac surgery. While some studies reported a decrease in the incidence of transfusion and in the volume of red blood cells transfused, only limited evidence exists in infants and children undergoing cardiac surgery. Major differences exist between children and adults undergoing cardiac surgery, limiting the use of ANH to a small number of ...
The purpose of this study is to help us learn how to lower the risk of a blood transfusion during surgery to remove ovarian cancer. Acute normovolemic hemodilution (ANH) is a technique performed in the operating room before the procedure begins that may reduce the risk of needing a transfusion during ovarian cancer surgery. During surgery, the patients own blood is given back to them when needed, usually due to bleeding. If you dont need blood during surgery, your own blood will be given back at the end of the case.. The idea behind ANH is that that by removing the blood and replacing it with other fluids, the remaining blood becomes diluted. This diluted blood is then lost during surgery, usually due to bleeding. The original non-diluted blood is then transfused back as needed. This may mean a lower chance of needing an additional blood transfusion.. ANH has been studied at this hospital for other types of cancer. These studies suggest that ANH may help conserve blood. Although most studies ...
TY - JOUR. T1 - Isovolemic hemodilution in experimental focal cerebral ischemia. Part 1. T2 - Effects on hemodynamics, hemorheology, and intracranial pressure. AU - Tu, Y. K.. AU - Heros, R. C.. AU - Candia, G.. AU - Hyodo, A.. AU - Lagree, K.. AU - Callahan, R.. AU - Zervas, N. T.. AU - Karacostas, D.. PY - 1988/1/1. Y1 - 1988/1/1. N2 - A total of 76 splenectomized dogs were entered in a study of the value and effects of isovolemic hemodilution. Of these, seven were not included in the analysis because of technical errors. Of the remaining 69 dogs, 35 were treated with hemodilution; 28 were subjected to a 6-hour period of temporary occlusion of the distal internal carotid artery and the proximal middle cerebral artery, and seven underwent a sham operation only, with arterial manipulation but no occlusion. The other 34 dogs were not subjected to hemodilution; 26 of these underwent temporary arterial occlusion and eight had a sham operation only. In each group the animals were about equally ...
Simultaneous investigations of maternal cardiac output and fetal blood flow during hypervolemic hemodilution in preeclampsia - preliminary ...
The last decades less invasive monitoring and analytical tools have been developed for the evaluation of myocardial mechanics in clinical praxis. In critical care, these are longed-for complements to pulmonary artery catheter monitoring, additionally offering previously inaccessible information. This work is aimed, during fluid-replacement and oxygen therapy, to determine the physiological interface of ventricular and vascular mechanical properties, which result in the transfer of blood from the heart to appropriate circulatory beds. In prospective clinical studies we investigated previously cardiovascular healthy adults during hyperoxemia, and during preoperative acute normovolemic hemodilution or early fluid resuscitation of severe burn victims. Echocardiography was used in all studies, transthoracic for healthy volunteers and transesophageal for patients. For vascular parameters and for control purposes pulmonary artery Swan-Ganz catheter, calibrated external pulse recordings, whole body ...
Authors: Kim, Doosang , Cho, Daniel J. , Cho, Young I. Article Type: Research Article Abstract: AIMS: Critical limb ischemia (CLI) patients are characterized by intractable pain in spite of medication, non-healing ulcers, and gangrene. The objective of this study was to investigate whether or not isovolemic hemodilution treatment can reduce the rate of major amputations in CLI. METHODS: 28 patients were studied who had tissue loss on Rutherford Grade III, Category 5 or 6. The subjects were divided into two arms: standard-of-care, conventional therapy (CT) (n = 15) as a control group and hemodilution therapy (HT) (n = 13) as a study group. For the HT group, weekly isovolemic hemodilution was performed over 4 consecutive …weeks, removing 250 ml of whole blood with the infusion of hydroxyl-ethyl starch solution. Blood viscosity, hematocrit, hemoglobin, ankle-brachial index, VA pain scale, time-to-amputation from admission, and survival time were measured. RESULTS: The mean Hct gradually decreased ...
TY - JOUR. T1 - Solute mass balance during isovolaemic high volume haemofiltration. AU - Uchino, Shigehiko. AU - Cole, Louise. AU - Morimatsu, Hiroshi. AU - Goldsmith, Donna. AU - Ronco, Claudio. AU - Bellomo, Rinaldo. PY - 2003/9/1. Y1 - 2003/9/1. N2 - Objective: To evaluate the effect of changing the amount of pre-dilution replacement fluid on the sieving coefficient (SC) and mass transfer of small solutes during isovolaemic high-volume haemofiltration (HVHF). Design and setting: Prospective interventional study in the intensive care unit of a tertiary university hospital. Patients: Eight patients with septic shock. Interventions: Isovolaemic HVHF (6 1/h of replacement fluid) was performed. The proportion of replacement fluid delivered in pre-filter was altered to progressively decrease it from 6 to 0 l/h. Samples were simultaneously taken from the pre-filter, post-filter and ultrafiltrate (UF) sampling ports. Measurements and results: Sodium, potassium, chloride, total calcium, total ...
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We present a case of extreme hemodilution in which appropriately crossmatched blood was not available. A 53-year-old man was admitted to our hospital because of hemorrhagic shock due to multiple stab wounds. His blood type was B, Rh negative, and his intravascular fluid volume was maintained with ba …
To test the hypothesis that lowering the haemoglobin concentration pre-operatively improves wound healing 52 Wistar rats were randomly allocated into two groups: group A were haemodiluted pre-operatively by ten per cent of their blood volume; group
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TY - JOUR. T1 - Asymptomatic carotid disorder and hemodilution. T2 - a perioperative study in major orthopaedic surgery.. AU - Bombardini, T.. AU - Borghi, B.. AU - Mattioli, R.. AU - Gargioni, G.. PY - 1995/1. Y1 - 1995/1. N2 - The aim of this study was to assess the pattern of adaptation to severe Haemodilution in pts with normal or stenotic carotid vessels. We enrolled 180 consecutive pts undergoing total hip replacement: 138 pts had echo-Doppler documented normal carotid arteries, 10 pts had kinking and 32 pts had monolateral or bilateral stenosis of internal carotid arteries (lesions, class of stenosis 1-49%). Haemoglobin values on the 4th day after surgery was 8.7 +/- 1.2 g/dl with no statistically significant differences in pts (patients) with carotid disorders versus normal pts. No pt showed clinical signs of cerebral ischemia or brain damage in the postoperative period. These results are consistent with experimental and clinical data showing that normovolaemic anaemia is well tolerated ...
In order to demonstrate that hyponatraemia due to haemodilution occurs within the left ventricle following freshwater drowning, and to determine whether lysed blood resulting from left ventricular haemodilution may cause staining of the aortic intima, the following studies were undertaken. Measurements of left ventricular sodium levels were performed in 74 consecutive coronial cases where death was attributed to drowning, consisting of 44 and 30 deceased who were believed to be victims of freshwater and saltwater drowning, respectively. Left ventricular sodium levels differed significantly between the two groups (p , 0.001), with a range of 93-147 mmol/L in freshwater drowning (mean = 117 ± 14.2 mmol/L) and 123-183 in saltwater drowning (mean = 153 ± 14.4 mmol/L). In addition, the mean sodium level of 117 mmol/L in freshwater drowning was significantly lower than the standard range of 137-145 mmol/L. In a second study, portions of aorta and pulmonary trunk from a euthanised pig were soaked in ...
The present invention relates to a system for the collection and re-infusion of blood in to a human body just before surgery. More specifically, it is a system and method for the collection and re-infusion blood to human body. It is used for collecting the blood just before the surgery within a short span of time and anti-coagulating patients blood for re-infusion in to the same patient. In this invention, two single tube segments are connected to two PVC blood bags as shown in the figure (1). Then these tubes are connected to Y connector through the roller cum stripper and 5 clamps and the same is then connected to the gauze needle covered with needle safety shield. The transfusion bag is provided with a Rotary shaker for the mixing of the solution with blood so that the time of the clinicians can be saved. Alternatively, a printed scale is provided on b side of the bag, and one S hook is provided at the lowest part of the bag which helps to collect blood in the OT without the help of any ...
Hemodilution was avoided with the drainage of irrigation fluid via a remaining ventricular cannula. Results: Direct endoscopic visualization of your mitral valve within an in vivo beating coronary heart was acquired Evidently, avoiding systemic hemodilution. In the final experiment, edge-to-edge restore applying an endoscopic clip was productively executed. Use of an effective intracardiac irrigation strategy was essential for prosperous image acquisition and achievement of fix procedures. Conclusions: This acute animal review showed the specialized feasibility of beating-coronary heart mitral valve medical procedures below direct endoscopic imaging. Despite the fact that this analyze was carried out underneath open up-upper body problems, our effective experiment is often a starting point towards closed-upper body intracardiac surgery with direct endoscopic visualization ...
Yes, the suggestion itself is blasphemy, I know. Im not at all suggesting it be done. This is just a hypothetical!! So, in this thought-experiment,...
Acute normovolemic hemodilution (ANH) and volume loading (VL) are standard blood-sparing procedures. However, VL is associated with hypervolemia, which may cause tissue edema, cardiopulmonary complications and a prolonged hospital stay. The body reacts to hypervolemia with release of atrial natriuretic peptide (ANP) from the heart. ANP has been shown to deteriorate the endothelial glycocalyx, a vital part of the vascular permeability barrier. The aim of the present study was to evaluate and compare ANP release and damage to the glycocalyx during ANH and VL. ...
In one of the largest randomized controlled trials (RCTs) on GDT, the incidence of blood transfusions was double (22 vs 11%) in the GDT group patients, who received nearly twice the amount of colloids compared to the control group, even though the same transfusion threshold (Hb , 8 g/dl) was used for both groups [11]. The most feasible explanation for this clinically relevant and statistically significant difference (p = 0.04 based on a chi square test), which was not calculated nor discussed in the article [11], is that more patients in the GDT group reached Hb levels below the transfusion threshold due to hemodilution, prompting physicians to order blood transfusions. Other RCTs have also reported that patients in the GDT group, who received significantly more colloid boluses, received significantly more blood transfusions [12, 13] and had significantly higher blood loss [13] compared to the standard therapy group. In another study, the administration of more colloids led to lower Hb and DO2 ...
An hematocrit of 21-25% is supposed to perform the best organ protection during cardiopulmonary bypass for cardiac surgery.. The investigators want to establish the best timing for a transfusion (in patients with a predicted low hematocrit during cardiopulmonary bypass) and the efficacy of preprocedural hemodilution (in patients with a predicted high hematocrit during cardiopulmonary bypass) in patients undergoing cardiac surgery. ...
Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia ...
Acute Kidney Injury, Adult, Association, Bleeding, Blood, Cardiac Output, Cardiac Surgery, Confidence Interval, Hematocrit, Hemodilution, Hospital, Injury, Kidney, Low Cardiac Output, Mechanical Ventilation, Methods, Morbidity, Mortality, Odds Ratio, Patient
Bakgrund: När en person drabbats av stroke är det i många fall även närstående som påverkas och måste anpassa sig till den nya situationen. Syfte: Syftet var att beskriva negativa respektive positiva upplevelser av att vara anhörigvårdare till en person som drabbats av stroke. Metod: Litteraturöversikt med granskning av 15 kvalitativa studier publicerade mellan åren 2006-2012. Resultat: Utifrån anhörigvårdarnas upplevelser av vårdarbetet framkom tio teman. Huvudresultatet var att de upplevde vårdarbetet som betungande, utmattande, bekymrande med brist på egentid och avlastning. De upplevde också brist på stöd från familj, vänner, samhälle och sjukvård. Anhörigvårdarna upplevde sig utlämnade och oförberedda i sin nya roll som vårdare och ansåg sig inte ha fått tillräcklig undervisning i vad rollen skulle innebära och vad de kunde förvänta sig. De positiva upplevelserna var att relationerna stärktes inom familjerna och anhörigvårdarna lärde sig att uppskatta ...
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Hemato-Clad* Mylar*-Wrapped Hematocrit Tubes - ID: 1.1 to 1.2mm;3080677PK : Pack of 200 Description ·The chance of co
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Search information on Hematocrit (16803) and 1000s of other diseases, symptoms, drugs, doctors, specialists, and clinics in our trustworthy medical i
We report on the anesthetic management of a 69-year-old female Jehovahs Witness undergoing cardiopulmonary bypass to replace the ascending aorta; the patient refused transfusion of stored autologous or allogeneic blood products for religious reasons. The strategy involved preoperative hematopoiesis with recombinant human erythropoietin and iron, intraoperative acute normovolemic hemodilution, the use of a cell-saver system, administration of high-dose tranexamic acid, controlled hypotension, avoidance of low body temperature, simplification of the surgery, and lower blood dilution during cardiopulmonary bypass.
View more ,A telephone survey of cardiac anaesthetists and perfusionists at the 29 public hospitals providing adult cardiac surgical services in Australia and New Zealand was carried out between December 2019 and January 2020. The aim was to investigate current practice with regard to selected contentious elements of anaesthetic and perfusion management during cardiopulmonary bypass; primarily relating to bypass circuit priming, blood conservation methods and point-of-care coagulation testing. There was a 100% response rate. The average number of adult public cardiopulmonary bypass cases per hospital was 508 (160-1400). For cardiopulmonary bypass cases, ten hospitals (34%) routinely used a cell saver and the remainder used a cell saver selectively. Residual blood remaining in the cardiopulmonary bypass circuit was processed using a cell saver routinely in four hospitals (14%) and selectively in 23 (79%). Acute normovolaemic haemodilution was rarely used. Retrograde autologous priming was used ...
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TY - CONF. T1 - Iron metabolism defined using stable isotopes in obesity. AU - Isabelle Herter-Aeberli. AU - Michael B. Zimmermann. AU - Cepeda López, Ana Carla. PY - 2018/12/8. Y1 - 2018/12/8. N2 - Introduction Iron deficiency is common in overweight (OW) and obese (OB) individuals and was shown to be at least partially mediated by adiposity-related inflammation. The proinflammatory cytokine interleukin 6 (IL6) induces hepcidin expression which may lead to decreased intestinal iron absorption. On the other hand, greater blood volume in OW/OB individuals may increase hemoglobin mass and iron requirements and confound iron biomarkers by hemodilution. Using stable iron isotopes, we have systematically studied iron metabolism in obesity. We have answered the following questions: 1) to what extent is hemodilution responsible for low iron status in OW/OB individuals; 2) what is the difference in iron absorption in OW/OB compared to normal weight (NW) participants and to what extent can ascorbic acid ...
Background: Clonidine effectively decreases perioperative mortality by reducing sympathetic tone. However, application of clonidine might also restrict anaemia tolerance due to impairment of compensatory mechanisms. Therefore, the influence of clonidine induced, short-term sympathicolysis on anaemia tolerance was assessed in anaesthetized pigs. We measured the effect of clonidine on anaemia tolerance and of the potential for macrohemodynamic alterations to constrain the acute anaemia compensatory mechanisms. Methods: After governmental approval, 14 anaesthetized pigs of either gender (Deutsche Landrasse, weight (mean ± SD) 24.1 ± 2.4 kg) were randomly assigned to intravenous saline or clonidine treatment (bolus: 20 μg · kg−1, continuous infusion: 15 μg · kg−1 · h−1). Thereafter, the animals were hemodiluted by exchange of whole blood for 6 % hydroxyethyl starch (MW 130.000/0.4) until the individual critical haemoglobin concentration (Hbcrit) was reached. Primary outcome parameters ...
Does Initial Hematocrit Predict Shock?. Everything you know is WRONG!. The classic textbook teaching is that trauma patients bleed whole blood. And that if you measure the hematocrit (or hemoglobin) on arrival, it will approximate their baseline value because not enough time has passed for equilibration and hemodilution. As Ive said before, youve got to be willing to question dogma!. The trauma group at Ryder in Miami took a good look at this assumption. They drew initial labs on all patients requiring emergency surgery within 4 hours of presentation to the trauma center. They also estimated blood loss in the resuscitation room and OR and compared it to the initial hematocrit. They also compared the hematocrit to the amount of crystalloid and blood transfused in those areas.. Patients with lower initial hematocrits had significantly higher blood loss and fluid and blood replacement during the initial treatment period. Some of this effect may be due to the fact that blood loss was ...
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In this study, we investigated the mechanisms underlying the changes in intestinal microcirculatory oxygenation induced by acute normovolemic HD. Our results show that severe HD is associated with redistribution of O2 delivery away from the intestines and also shunting of the residual O2 within the intestines itself. The correlation between mucosal μHbO2 and μPo2 during reduction of intestinal microvascular oxygenation indicates that impaired erythrocyte O2 off-loading is not the key mechanism responsible for the decreased microcirculatory mucosal oxygenation. Thus O2 shunting bypassing the microcirculation to the venous compartment appears to be the main factor. Herein, rheological alterations may contribute, and a potential candidate is the observed erythrocyte rigidification during ANH.. In HD pigs, mucosal μHbO2 was well preserved during mild ANH but finally progressively declined. This finding of a two-phase response of intestinal microvascular oxygenation (maintained oxygenation during ...
Hemodilution of the plasma by more than 20% associated with priming cardiopulmonary bypass pumps, plasma volume expansion or other fluid administration therapies using certain solutions may cause clinically significant error on ionized calcium results. These errors are associated with solutions that do not match the ionic characteristics of plasma. To avoid these errors when hemodiluting by more than 20%, use physiologically balanced multi-electrolyte solutions containing low-mobility anions (e.g. Gluconate) such as Normosol-R (Abbott Laboratories), Plasma-Lyte-A (Baxter Healthcare oCrporation), and Isolyte-S (B Braun Medical) rather than solutions such as normal saline or ringers lactate.. ...
Transport of biological available oxygen in vertebrates is performed by two different principles: physical solution in plasma and chemical binding to the haemoglobin molecule. According to these...
The natural physiological changes in pregnancy, such as hemodilution and a mild thrombocytopenia may help to ameliorate the thrombotic diathesis that is
Traditional cardiopulmonary bypass (CPB) techniques have suffered from a number of disadvantages including haemodilution, inflammation and post-operative
Man has been very ingenious in attempting to find ways to make up for or compensate for his own shortcomings as to diet and lifestyle. We find persons who take yeast regularly. At first, they experience stomach pains which are early warning signs that the body is rejecting this vile substance but, as is usual, as the individual persists in ingesting it, the system soon accommodates to the poison, giving up vital force in doing so.. Anemic people religiously take their iron pills hoping to cure their anemia. While they may experience stimulation, they cure nothing. Their bodies continue to deteriorate both in structure and function. We know one woman who stoutly maintains that her anemic condition was cured by taking iron pills as prescribed by her physician. She has been taking these iron pills for over fifteen years. We look at her and wonder to what purpose as we see the pasty complexion, the curving spine and the appearance of premature wrinkles on her face. We ask, But where is your ...
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TABLE OF CONTENTS Page TABLE OF CONTENTS . i LIST OF TABLES iii LIST OF FIGURES v CHAPTER I. THE PROBLEM 1 Introduction 1 Scope, limitation and delimitation of the study . 10 Significance of the study 11
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Spin 12 special 40mm hematocrit tubes in the flat12-place flat hematocrit rotor. (Included is one vial of 200 40x0.034mm capillary tubes.)
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What is the normal hematocrit for pregnancy? Answered by Dr. Gurmukh Singh: Higher than 36: See this site for more information. http://www.nlm.nih...
He had a hematocrit above 50 before the start of Tre Valli Varesine, 17 August. He was suspended for 15 days. (source: cyclingnews.com ...
Hemodilution[edit]. Hemodilution is the dilution of the concentration of red blood cells and plasma constituents by partially ... "Hemodilution:Modelling and clinincal Aspects. 1. IEEE. pp. 177-179. doi:10.1109/IEMBS.2001.1018881. ISBN 978-0-7803-7211-5.. ... Acute Normovolemic Hemodilution. ANHu. Number of Units During ANH. BLH. Maximum Blood Loss Possible When ANH Is Used Before ... Clearly, the greater the Hi and the greater the number of units removed during hemodilution, the more effective ANH is for ...
Isovolemic hemodilution; Anticoagulation; Dislodging or fragmenting thrombus or embolus; Thrombolysis; and Hyperbaric oxygen. ...
Shander A, Rijhwani TS (December 2004). "Acute normovolemic hemodilution". Transfusion. 44 (12 Suppl): 26S-34S. doi:10.1111/j. ... "Acute Normovolemic Hemodilution Reduces Allogeneic Red Blood Cell Transfusion in Cardiac Surgery: A Systematic Review and Meta- ... acute normovolemic hemodilution" involves the collection of a selected calculated volume of autologous blood in collection bags ...
Hemodilution can be normovolemic which, as we said, implies the dilution of normal blood constituents by the use of expanders. ... Before we look at the main issue, hemodilution, let us take a brief history into the use of blood. Its therapeutic use is not a ... Hemodilution is the dilution of the concentration of red blood cells and plasma constituents by partially substituting the ... Clearly, the greater the Hi and the greater the number of units removed during hemodilution, the more effective ANH is for ...
Her thesis was on Myocardial Ischemia and the use of non-typing artificial blood in hemodilution.[citation needed] Beresford- ... 1984 Oct;62(10):1333-7. Myocardial blood flow and O2-supply following dextran-haemodilution and methaemoglobinaemia in the dog ... Myocardial oxygen-supply during hemodilution with stroma-free hemoglobin and methemoglobin solutions. Biro GP, Beresford- ... hemorheologic changes following acute experimental coronary occlusion and salutary antihyperviscosity effect of hemodilution ...
November 2007). "Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer". JAMA. 298 (19): ...
"Validation of OPS imaging for microvascular measurements during isovolumic hemodilution and low hematocrits". Am J Physiol ...
However, there are still some studies showing a failure of RAP to limit the hemodilution after the open heart operation. The ... The hemodilution is the primary hematologic interference which results in coagulopathy and decreased capability of carrying ... Although RAP is an effective and safe technique to reduce the hemodilution during CPB, there are still some potential risks of ... Thus, there is a high incidence of distinct degrees of hemodilution with CPB. RAP is a blood conservation technique to decrease ...
"Blood Volume Analysis Can Distinguish True Anemica From Hemodilution in Critically Ill Trauma Patients". Western Trauma ...
Control for Compartmental Systems with Application to Introoperative Anesthesia Influenced by Hemorrhage and Hemodilution ...
In reality various effects overlap, including haemodilution or application of high doses of parenteral anticoagulants. High ...
Transfusions of autologous blood part of a "current therapy". Hemodilution, a modified technique in which equipment is arranged ... In 1989 The Watchtower stated, "Each individual must decide" whether to accept hemodilution and autologous blood salvage (cell ... such as hemodilution or cell salvage, are a matter of personal choice, according to what a person's conscience permits. A ...
"Custom-tailored hemodilution with albumin and crystalloids in acute ischemic stroke". Department of Rheology, St. Lucas ...
The hemodilution caused by volume expansion with dextran use improves blood flow, thus further improving patency of ...
Nazih Zuhdi performed the first total intentional hemodilution open-heart surgery on Terry Gene Nix, age 7, on 25 February 1960 ... using the total intentional hemodilution machine. In the early 1990s, surgeons began to perform off-pump coronary artery bypass ...
Hemodilution, a modified technique in which equipment is arranged in a circuit that is constantly linked to the patient's ... In 1989 The Watchtower stated, "Each individual must decide" whether to accept hemodilution and autologous blood salvage (cell ... such as hemodilution or cell salvage, are a matter of personal choice, according to what a person's conscience permits.[19] ...
... this parameter is decreased by crystalloids due to hemodilution. Therefore, they should theoretically preferentially increase ...
... this parameter is decreased by crystalloids due to hemodilution. Crystalloids generally are much cheaper than colloids. Buffer ...
Nazih Zuhdi performed the first total intentional hemodilution open heart surgery on Terry Gene Nix, age 7, on February 25, ... using the total intentional hemodilution machine. In 1985 Zuhdi performed Oklahoma's first successful heart transplant on Nancy ...
... this parameter is decreased by crystalloids due to hemodilution.[2] There does not appear to be a benefit of using colloids ...
... can be tracked noninvasively, to build an individual data set tracking the hemoconcentration and hemodilution ...
... and hemodilution (mild dilution of the blood). Evidence for this approach is inconclusive; no randomized controlled trials have ...
Many doctors view acute normovolemic hemodilution, a form of storage of a patient's own blood, as a pillar of "bloodless ...
A Saprolegnia infection is usually fatal, eventually causing hemodilution, though the time to death varies depending on the ...
... and hemodilution. Sometimes, perfusionists are granted administrative tasks such as purchasing supplies or equipment, as well ...
... hemodilution [as in pregnancy], increased vascular permeability or decreased lymphatic clearance) Acute disease states ( ...
... and hemodilution (thinning of the blood) coupled with drug-induced hypertension are some treatment techniques currently under ...
... hemodilution Archived September 7, 2008, at the Wayback Machine, heart lung machine, dialysis, epidural blood patch Archived ...
... and hemodilution HHH (disambiguation) This disambiguation page lists articles associated with the title Triple H. If an ...
Tolerance to acute isovolemic hemodilution. Effect of anesthetic depth.. Van der Linden P1, De Hert S, Mathieu N, Degroote F, ... 2.5 +/- 0.6 g/dl, P , 0.05). This was related to a marked blunting of the cardiac output response to hemodilution in the ... Oxygen delivery and oxygen consumption were determined from independent measurements during a stepwise isovolemic hemodilution ...
Learn more about hemodilution misplacement causing cerebral desaturation. Mechanism of injury, Associated outcome and ... Minimally Invasive Therapies Clinical Solutions Cerebral Desaturation during Cardiac Surgery Causes Hemodilution ... Learn more about hemodilution causing cerebral desaturation:. Mechanism of Injury. *Intraoperative anemia increases the risk ... Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly. Anesthesiology. 2007;107(4):577- ...
Procedure: Different timing of red blood cells transfusion (substudy 1); Acute hemodilution versus no hemodilution (substudy 2) ... Acute hemodilution versus no hemodilution (substudy 2) Subgroup 1,with Ht,21% receive an hemotransfusion before or after CEC; ... Hemodilution and Outcome in Cardiac Surgery. This study has been terminated. (difficult enrollment after the primary ... Hemodilution. Blood Transfusion. Cardiopulmonary Bypass. Multiple Organ Failure. Surgery, Cardiac. Kidney Failure. Cardiac ...
Hyperoxic hemodilution i.e. the combination of intraoperative extreme hemodilution and hyperoxic ventilation may therefore be ... without transfusion by intraciperative normovolemic hemodilution. However major blood loss results in extreme hemodilution and ... Habler, Oliver; Kleen, Martin; Kemming, Gregor und Zwissler, Bernhard (2002): Hyperoxia in extreme hemodilution. In: European ...
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... Marion Bienert,1 ... Blood pressure and heart rate remained unchanged. Conclusions. Hypervolemic hemodilution has an acute effect on blood flow ... Purpose. Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a ...
"Hemodilution" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are MeSH descriptors whose meaning is more general than "Hemodilution".. *Analytical, Diagnostic and Therapeutic ... This graph shows the total number of publications written about "Hemodilution" by people in Harvard Catalyst Profiles by year, ... Greater Volume of Acute Normovolemic Hemodilution May Aid in Reducing Blood Transfusions After Cardiac Surgery. Ann Thorac Surg ...
Haemodilution for acute ischaemic stroke. Question We wanted to compare the effectiveness of haemodilution (diluting the blood ... are more effective as haemodilution agents. In many countries, haemodilution has been used in clinical treatment of people with ... Haemodilution can be achieved by blood-letting (removing blood), by giving fluids as an infusion or by a combination of both. ... Haemodilution is thought to improve the flow of blood to the affected areas of the brain and thus reduce infarct size. ...
Active Comparator: Hemodilution hemodilution using erythrocytapheresis is performed as early as possible after inclusion, in ... Procedure: hemodilution hemodilution using erythrocytapheresis - target hematocrit: 35% - as soon as possible after the ... Hemodilution Versus Ranibizumab in Early-onset Central Retinal Vein Occlusion (CHIC-3). The safety and scientific validity of ... Hemodilution Versus Ranibizumab in Early-onset Central Retinal Vein Occlusion. Official Title ICMJE Pilot Study on Efficacy and ...
... hemodilution may therefore be responsible for the lower serum PSA concentrations among obese men with prostate cancer. ... Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer JAMA. 2007 Nov 21;298(19):2275-80. doi ... Objective: To determine the association between hemodilution and PSA concentration in obese men with prostate cancer. ... Conclusions: In men undergoing radical prostatectomy, higher BMI was associated with higher plasma volume; hemodilution may ...
Improving outcomes from resuscitation: from hypertension and hemodilution to therapeutic hypothermia to H2.. Drabek T1, ...
Hemodilution and Candles You will receive an email whenever this article is corrected, updated, or cited in the literature. You ... 2 The concept that hemodilution might save erythrocytes per se appears to have been first envisioned by Messmer et al . 3 The ... 8 The safe limits of hemodilution for patients who cannot increase blood flow sufficiently to critical organs (e.g. , because ... Hemodilution has not been associated with systemic or cardiac markers of inadequate oxygenation in patients undergoing coronary ...
... Perez de Sá, Valéria LU ; Békássy, Albert LU ; Schou, Henning LU ; ... HEMODILUTION-bone marrow harvesting, ANESTHESIA, BONE MARROW HARVESTING, BLOOD. in Anesthesia and Analgesia. volume. 72. issue ... H is concluded that the hemodilution resulted in a statistically but not clinically significant decrease in Scvo2 that was well ... H is concluded that the hemodilution resulted in a statistically but not clinically significant decrease in Scvo2 that was well ...
Effects of hemodilution and pentoxifylline. Angelkort, B.. Wiener Medizinische Wochenschrift 136 Spec No: 29-35. 1986. ... Employment of hemodilution and administration of the rheologically active drug pentoxifylline are quoted as exemplary ...
With this oxygen-carrying colloid we performed extreme isovolemic haemodilution in dogs and examined the changes in different ... Klein G., Ferber H., Ottermann U., Förster H. (1986) Changes in Important Biochemical Parameters Due to Extreme Haemodilution ... Changes in Important Biochemical Parameters Due to Extreme Haemodilution with Cross-linked Stromafree Haemoglobin Solution. ...
Results: During hemodilution, cardiac output by thermodilution increased by 16 ± 7% and 26 ± 10%, corresponding well to the ... The aims of our study were to describe the hemodynamic effects of normovolemic hemodilution and to determine its effect on ... Cardiovascular response to hyperoxemia, hemodilution and burns: a clinical and experimental study. Bak, Zoltan Linköping ... During preoperative acute normovolemic hemodilution a reduction of hemoglobin to 80 g/l did not compromise systolic or ...
The effects of normovolaemic haemodilution on degree of lymphocyte apoptosis during CABG: 003. Dąbrowski, W.1; Korycińska, A.2 ... Introduction: The influence of normovolaemic haemodilution (NH) on lymphocyte apoptosis (LA) is not clear. The aim of this ... The effects of normovolaemic haemodilution on degree of lymphocyte apoptosis during CABG: 003 ...
We present a case of extreme hemodilution in which appropriately crossmatched blood was not available. A 53-year-old man was ... Extreme hemodilution can be successfully managed by maintaining a normal blood volume, 100% oxygen, and the use of plasma ... Case report: intraoperative management of extreme hemodilution in a patient with a severed axillary artery Anesth Analg. 2010 ... We present a case of extreme hemodilution in which appropriately crossmatched blood was not available. A 53-year-old man was ...
Acute normovolemic hemodilution (ANH) Patients undergoing acute normovolemic hemodilution (ANH) as part of their cardiac ... The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH). The safety and ... Procedure: Acute normovolemic hemodilution (ANH) Blood is drawn from our patients pre-bypass after obtaining the arterial line ... Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease post-operative bleeding and homologous blood ...
Influence of Barbiturates, Hypothermia and Hemodilution on Post-Ischemic Metabolism and Functional Recovery Following Cerebro- ... 1980) Influence of Barbiturates, Hypothermia and Hemodilution on Post-Ischemic Metabolism and Functional Recovery Following ... effect of hemodilution and perfusion pressure. Stroke 3: 538-542.PubMedCrossRefGoogle Scholar ...
This study was designed to determine if coexisting metabolic acidosis or normovolaemic haemodilution, or both, modifies the ... This study was designed to determine if coexisting metabolic acidosis or normovolaemic haemodilution, or both, modifies the ... Normovolaemic haemodilution was undertaken by phlebotomy and simultaneous exchange with lactated Ringers solution at 37 ... but was attenuated in the presence of normovolaemic haemodilution.. ...
Simultaneous investigations of maternal cardiac output and fetal blood flow during hypervolemic hemodilution in preeclampsia - ...
Tolerance to Acute Isovolemic Hemodilution: Effect of Anesthetic Depth Philippe Van der Linden, M.D., Ph.D.; Stefan De Hert, M. ... During the hemodilution protocol, Do2decreased progressively in both the halothane and the ketamine studies as a result of the ... In all animals, acute isovolemic hemodilution resulted in a significant decrease in MAP and in SVR (table 1). In the 1.0 MAC ... We tested this hypothesis in a dog model of stepwise isovolemic hemodilution. In the first study, we assessed the effects of ...
The isovolumetric hemodilution treatment reduces ischemic injury and anti‐radical interventions may reduce reperfusion injury. ... Effects of isovolumetric hemodilution treatment and superoxide dismutase on ischemic reperfused hearts in rabbit Article type: ... Ten animals in each group received: (i) normal saline only; (ii) isovolumetric hemodilution with Dextran 40 during ischemia; ( ... Abstract: The isovolumetric hemodilution treatment reduces ischemic injury and anti‐radical interventions may reduce ...
... were treated by isovolemic hemodilution. The procedure consisted of the daily withdrawal of 500 ml of blood, which is replaced ... Use of hemodilution in patients with arteriopathy: Effects on hemorheological parameters and platelet function Article type: ... Keywords: Isovolemic hemodilution, arteriopathy, human albumin, hemorheology, platelet activation, Dextran. DOI: 10.3233/CH- ... Abstract: Sixteen arteritic patients at stage II, III and IV according to Fontaine, were treated by isovolemic hemodilution. ...
Following isovolemic hemodilution (AIH), lowering blood viscosity induces acceleration of erythrocyte velocity resulting in ... 42%, p < .05).Preischemic hemodilution significantly attenuated myocardial damage as shown by lower release of cardiac troponin ... Cardioprotective effects of acute isovolemic hemodilution in a rat model of transient coronary occlusion* ... Objectives:Following isovolemic hemodilution (AIH), lowering blood viscosity induces acceleration of erythrocyte velocity ...
Acetylsalicylic acid Terminated Phase 3 Trials for Hemodilution / Retinal Artery Occlusions / Fibrinolysis / Visual Acuity / ...
Conclusions: In this large cohort of patients hospitalized for HF with reduced EF, early post-discharge hemodilution was ... However, the relationship between early post-discharge hemodilution, markers of congestion, and clinical outcomes is unknown. ... Abstract 18059: Clinical Profile and Prognostic Significance of Post-Discharge Hemodilution Among Patients Hospitalized for ... patients had evidence of hemodilution (≥4% absolute decrease in hematocrit). During the 1-month post-discharge period, ...
Both haemodilution and mild hypothermia impaired coagulation. Coagulopathy was more pronounced after haemodilution with ... Haemodilution and hypothermia induce coagulopathy separately, but their combined effect on coagulation has not been widely ... Free oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII ... There was a significant interaction between haemodilution with hydroxyethyl starch and hypothermia, resulting in increased ...
... in reflecting iatrogenic hemodilution during incremental fluid administration of patients undergoing major surgery.1 This press ... effects of incremental fluid loading on oxygen delivery and on LabHb and SpHb as markers of possible iatrogenic hemodilution, ... development of iatrogenic hemodilution. The development of iatrogenic hemodilution is reflected by a real-time decrease in the ... in reflecting iatrogenic hemodilution during incremental fluid administration of patients undergoing major surgery.1 ...
  • Tolerance to acute isovolemic hemodilution. (nih.gov)
  • Oxygen delivery and oxygen consumption were determined from independent measurements during a stepwise isovolemic hemodilution protocol. (nih.gov)
  • With this oxygen-carrying colloid we performed extreme isovolemic haemodilution in dogs and examined the changes in different biochemical parameters. (springer.com)
  • Indeed, anesthetic agents could alter the compensatory mechanisms implicated during isovolemic hemodilution, especially the CO response. (asahq.org)
  • We tested this hypothesis in a dog model of stepwise isovolemic hemodilution. (asahq.org)
  • Sixteen arteritic patients at stage II, III and IV according to Fontaine, were treated by isovolemic hemodilution. (iospress.com)
  • Following isovolemic hemodilution (AIH), lowering blood viscosity induces acceleration of erythrocyte velocity resulting in improved tissue oxygen delivery. (ovid.com)
  • Background: Therapeutic isovolemic hemodilution has been reported to improve blood flow and oxygen delivery. (elsevier.com)
  • We measured retinal oxygen tension during experimental isovolemic hemodilution in normal cats. (elsevier.com)
  • Results: Tissue oxygen tension increased initially during isovolemic hemodilution to a maximum approximately 50% above baseline at approximately two thirds of the original hematocrit level. (elsevier.com)
  • Cardiac output measured in one cat undergoing isovolemic hemodilution increased as hematocrit was lowered, but the cardiac erythrocyte flux actually decreased steadily. (elsevier.com)
  • Acute isovolemic hemodilution triggers proinflammatory and procoagulatory endothelial activation in vital organs: role of erythrocyte aggregation. (ox.ac.uk)
  • These patients are severely hemodiluted due to preoperative isovolemic hemodilution (IHD), circuit priming, and large fluid infusions perioperatively. (ox.ac.uk)
  • CONCLUSIONS: These results suggest that low erythrocyte aggregation might trigger endothelium-dependent thrombogenic and proinflammatory response during acute isovolemic hemodilution. (ox.ac.uk)
  • We used 44 splenectomized dogs to study the effects of isovolemic hemodilution with a crystalloid solution. (elsevier.com)
  • This experimental study showed that acute isovolemic hemodilution to a hematocrit of 20% resulted in a decreased oxygen delivery to the brain as the increase in cerebral blood flow did not fully compensate for the decrease in arterial oxygen content. (nataonline.com)
  • Isovolemic hemodilution in experimental focal cerebral ischemia. (elsevier.com)
  • A total of 76 splenectomized dogs were entered in a study of the value and effects of isovolemic hemodilution. (elsevier.com)
  • Two isovolemic hemodilution steps were performed with a 6% Dextran 70 (70-kDa molecular mass) plasma expander until Hct was 35% of control. (elsevier.com)
  • The investigators want to establish the best timing for a transfusion (in patients with a predicted low hematocrit during cardiopulmonary bypass) and the efficacy of preprocedural hemodilution (in patients with a predicted high hematocrit during cardiopulmonary bypass) in patients undergoing cardiac surgery. (clinicaltrials.gov)
  • In the ideal case, a surgical blood loss can entirely be `bridged' without transfusion by intraciperative normovolemic hemodilution. (uni-muenchen.de)
  • However major blood loss results in extreme hemodilution and the transfusion of red blood cells may finally become necessary to increase arterial oxygen content and to preserve tissue oxygenation. (uni-muenchen.de)
  • Hyperoxic hemodilution i.e. the combination of intraoperative extreme hemodilution and hyperoxic ventilation may therefore be considered a cost-effective, safe and efficient supplement to reduce allogeneic transfusion during surgical interventions associated with high blood losses. (uni-muenchen.de)
  • It is well established that iatrogenic hemodilution may lead to increased blood transfusion due to dilutional coagulopathy and increased surgical bleeding. (biomedcentral.com)
  • The most feasible explanation for this clinically relevant and statistically significant difference ( p = 0.04 based on a chi square test), which was not calculated nor discussed in the article [ 11 ], is that more patients in the GDT group reached Hb levels below the transfusion threshold due to hemodilution, prompting physicians to order blood transfusions. (biomedcentral.com)
  • The goal of this cardiopulmonary bypass (CPB) quality improvement initiative was to maximize hemoglobin nadir concentration by minimizing hemodilution and, in turn, eliminating allogeneic blood product transfusion. (elsevier.com)
  • Justifications: Perioperative allogeneic blood transfusion can be reduced or even completely avoided by using a set of different strategies: meticulous hemostasis, the use of pharmaceutical agents that assist in the process of coagulation/ fibrinolysis, the use of blood substitutes, induced hypotension, preoperative autologous blood donation, collection and reinfusion of autologous blood during the operation, as well as from acute normovolemic hemodilution (ANH). (scirp.org)
  • Acute normovolemic hemodilution (ANH) has been used since the 60's and its aim is to reduce or even avoid the need for transfusion of homologous blood during the perioperative period [1-3]. (scirp.org)
  • Preoperative Acute Normovolemic Hemodilution for Minimizing Allogeneic Blood Transfusion: A Meta-Analysis. (bloodless.com.br)
  • Patients undergoing elective radical prostatectomy by one surgeon during a 3- yr period were analyzed retrospectively for blood loss, hematocrit levels, records of acute hemodilution, and transfusion outcomes. (northwestern.edu)
  • Background: Acute normovolemic hemodilution (ANH) is considered safe and effective in decreasing perioperative transfusion in paediatric populations undergoing high blood-loss surgeries. (elsevier.com)
  • Revisiting acute normovolemic hemodilution and blood transfusion during pediatric cardiac surgery: a prospective observational study. (nataonline.com)
  • If blood transfusion can be life-saving in some circumstances (e.g. major haemodilution or massive haemorrhage), the administration of large volumes of allogeneic blood products has been shown to significantly increase the risk of postoperative complications. (nataonline.com)
  • 1) To determine if hemodilution adequately meets the transfusion needs in children who undergo posterior spinal fusion for idiopathic scoliosis and 2) to compare the efficacy of the various methods used to reduce the risk of allogeneic blood transfusion at the authors' institution. (elsevier.com)
  • Methods to reduce blood loss and avoid allogeneic blood transfusion caused by extensive spinal surgery in adolescents include 1) autologous blood predonation, 2) controlled hypotensive anesthesia, 3) intraoperative salvage of shed blood (cell saver), 4) acute normovolemic hemodilution, and 5) transfusion decisions by clinical judgment rather than by a preset value of hemoglobin. (elsevier.com)
  • Hemodilution was safely used as a method to satisfy the perioperative transfusion requirements of adolescents undergoing extensive spinal surgery. (elsevier.com)
  • What effects do hemodilution and blood transfusion during cardiopulmonary bypass have on renal outcomes? (bloodjournal.ir)
  • This is a prospective randomized clinical trial to evaluate whether RAP can reduce hemodilution in CPB and prevent allogeneic blood transfusion. (bloodjournal.ir)
  • The team found that acute normovolemic hemodilution reduced the overall allogeneic red cell transfusion rate by 50% compared with standard anesthetic management. (gastrohep.com)
  • In patients with intraoperative blood loss 800 mL or more, acute normovolemic hemodilution reduced not only the allogeneic red cell transfusion rate in 18% vs 42% with standard anesthetic management. (gastrohep.com)
  • Given the modest transfusion rate in the standard anesthetic management arm, future efforts should attempt to target acute normovolemic hemodilution use to patients most likely to benefit. (gastrohep.com)
  • Acute normovolemic hemodilution (ANH), withdrawal of blood while maintaining isovolemia, was originally introduced to return coagulation factors to the patient after cardiopulmonary bypass. (asahq.org)
  • Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass. (clinicaltrials.gov)
  • To investigate the in vivo effects of cardiopulmonary bypass (CPB) and perioperative hemodilution on human skeletal muscle oxygen delivery and metabolism and to determine the dilution state at which these effects arise. (springermedizin.de)
  • Prevention of Hypokalemic Cardiac Arrhythmias Associated with Cardiopulmonary Bypass and Hemodilution. (rand.org)
  • Asopa S, Elahi M. Hemodilution during cardiopulmonary bypass: optimal hematocrit for safe outcome. (bloodjournal.ir)
  • An evidence-based review of the practice of cardiopulmonary bypass in adults: a focus on neurologic injury, glycemic control, hemodilution, and the inflammatory response. (bloodjournal.ir)
  • Hemodilution during cardiopulmonary bypass is an independent risk factor for acute renal failure in adult cardiac surgery. (bloodjournal.ir)
  • Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly. (medtronic.com)
  • We present a case of extreme hemodilution in which appropriately crossmatched blood was not available. (nih.gov)
  • Extreme hemodilution can be successfully managed by maintaining a normal blood volume, 100% oxygen, and the use of plasma substitutes. (nih.gov)
  • With the exception of extreme hemodilution situations, the capacity for tissue oxygen supply and demand will not be affected [5]. (scirp.org)
  • During preoperative acute normovolemic hemodilution a reduction of hemoglobin to 80 g/l did not compromise systolic or diastolic myocardial function. (diva-portal.org)
  • Masimo (NASDAQ:MASI) announced today the findings of an abstract presented at Euroanaesthesia 2018 in which researchers compared Masimo noninvasive and continuous hemoglobin (SpHb ® ) to intermittent and invasive lab hemoglobin (LabHb) in reflecting iatrogenic hemodilution during incremental fluid administration of patients undergoing major surgery. (ntbinfo.no)
  • Our study also demonstrates that continuous monitoring of hemoglobin (SpHb) through Masimo Pulse CO-Oximetry sensors may detect the development of such iatrogenic hemodilution in real time. (ntbinfo.no)
  • The only factor that correlates directly with the oxygen content variables and inversely with blood flow, and induces significant changes in tissue hemoglobin content and oxygen delivery, is hemodilution. (springermedizin.de)
  • Not until acute normovolemic hemodilution studies were performed were we able to progressively appraise how well patients could tolerate lower levels of hemoglobin without significant adverse outcomes. (ccjm.org)
  • The targets in these studies were modest at first, but researchers aimed progressively for more aggressive hemodilution with lower hemoglobin targets and demonstrated that the body can tolerate and adapt to more severe anemia. (ccjm.org)
  • Weiskopf et al 9 assessed the effect of severe anemia in 32 conscious healthy patients (11 presurgical patients and 21 volunteers not undergoing surgery) by performing acute normovolemic hemodilution with 5% human albumin, autologous plasma, or both, with a target hemoglobin level of 5 g/dL. (ccjm.org)
  • By allowing patients to arrive at surgery with a higher preoperative hemoglobin and hematocrit, and by decreasing the quantity of predonated autologous blood-collected and therefore used, the hemodilution method may indirectly decrease the quantity of postoperative autologous transfusions in this population. (elsevier.com)
  • BUSINESS WIRE )-- Masimo (NASDAQ: MASI) announced today that in a study recently published in Anesthesia & Analgesia, researchers evaluated the ability of noninvasive and continuous hemoglobin monitoring with Masimo SpHb ® to detect the development of acute hemodilution after graded fluid administration, by comparing it to invasively measured laboratory hemoglobin (BHb), on patients undergoing major surgery. (aetoswire.com)
  • In the acute normovolemic hemodilution group, intraoperative blood collection was performed to a target hemoglobin of 8.0 g/dL. (gastrohep.com)
  • The research team noted that acute normovolemic hemodilution patients had higher postoperative hemoglobin levels, and tended to require fewer red cell units overall. (gastrohep.com)
  • acute normovolemic hemodilution (ANH) reduces arterial hemoglobin (Hb) concentration, and thus arterial O 2 content, triggering compensatory mechanisms at different levels of O 2 transport to maintain tissue oxygenation. (physiology.org)
  • Myocardial oxygen-supply during hemodilution with stroma-free hemoglobin and methemoglobin solutions. (wikipedia.org)
  • Hypervolemic hemodilution after stroke. (ahajournals.org)
  • Ischemic ocular disorders may be treated by hypervolemic hemodilution. (hindawi.com)
  • Hypervolemic hemodilution has an acute effect on blood flow velocities in the CRA and PCAs in NAION patients. (hindawi.com)
  • After the induction of general anesthesia, all patients were loaded with 10 mL/kg of a 6% high-molecular dextran solution (Macrodex - Pharmacia), which resulted in a significant preoperative decrease in hematocrit (Hct) from 32% ± 6% to 28% ± 5% (hypervolemic hemodilution) and also allowed the procedure to be performed without systemic heparinization. (lu.se)
  • We compared the sensibility of SVV by Vigileo/Flotrac to central venous pressure (CVP) when volume changes in patients undergoing intraoperative acute normovolemic hemodilution (ANH) and acute hypervolemic hemodilution (AHH). (elsevier.com)
  • Greater Volume of Acute Normovolemic Hemodilution May Aid in Reducing Blood Transfusions After Cardiac Surgery. (harvard.edu)
  • Patients undergoing acute normovolemic hemodilution (ANH) as part of their cardiac surgery. (clinicaltrials.gov)
  • Acute normovolemic hemodilution (ANH) has been used for a long time in adults undergoing high bleeding risk procedures, including cardiac surgery. (nataonline.com)
  • ANCHOR=View Abstract],[LINK=/content/mitg/websites/languagemasters/emea/en-gb/support/clinical-evidence.html?id=297423]) , ([FOOTNOTE=Han SH, Bahk JH, Kim JH, et al. (medtronic.com)
  • article{fd86e506-a676-49f6-9f49-af306e85477f, abstract = {Haemodilution and hypothermia induce coagulopathy separately, but their combined effect on coagulation has not been widely studied. (lu.se)
  • abstract = "BACKGROUND: Prostate-specific antigen (PSA) hemodilution is the leading theory for lower PSA values in obese men. (wustl.edu)
  • The effects of normovolaemic haemodilution on degree of lymp. (lww.com)
  • The influence of normovolaemic haemodilution (NH) on lymphocyte apoptosis (LA) is not clear. (lww.com)
  • Normovolaemic haemodilution attenuates cardiac depression induced by sodium bicarbonate in canine metabolic acidosis. (biomedsearch.com)
  • This study was designed to determine if coexisting metabolic acidosis or normovolaemic haemodilution, or both, modifies the acute cardiodepressant effect of i.v. sodium bicarbonate. (biomedsearch.com)
  • These results indicate that the cardiodepressant effect of sodium bicarbonate 1 mmol kg-1 i.v. during metabolic acidosis was more pronounced than without acidosis, but was attenuated in the presence of normovolaemic haemodilution. (biomedsearch.com)
  • Effects of normovolaemic haemodilution on middle cerebral artery blood flow velocity and oxygen delivery. (nataonline.com)
  • Asymptomatic carotid disorder and hemodilution: a perioperative study in major orthopaedic surgery. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Asymptomatic carotid disorder and hemodilution: a perioperative study in major orthopaedic surgery. (elsevier.com)
  • Acute normovolemic hemodilution is safe in neurosurgery. (bloodless.com.br)
  • Dr Jarnagin s team concluded, For patients undergoing major liver resection, acute normovolemic hemodilution is safe, effectively reduces the need for allogeneic transfusions, and should be considered for routine use. (gastrohep.com)
  • 1. Bubenek S, Valeanu L, Popescu M, Cacoveanu M, Tomescu D, and Perel A. Optimization of cardiac output by incremental fluid administration is associated with iatrogenic hemodilution and a paradoxical decrease in oxygen delivery. (ntbinfo.no)
  • The effect of esmolol-induced controlled hypotension in combination with acute normovolemic hemodilution on cerebral oxygenation. (medtronic.com)
  • BACKGROUND: It is possible to perform acute normovolemic hemodilution (ANH) in combination with controlled hypotension (CH). In this randomized prospective study, we examined the effect of the combination of ANH and CH on cerebral oxygenation using near-infrared spectroscopy. (snu.ac.kr)
  • The authors investigated the impact of acute normovolemic hemodilution (ANH) on intrarenal oxygenation and its functional short-term consequences in pigs. (anestesiasegura.com)
  • Improving outcomes from resuscitation: from hypertension and hemodilution to therapeutic hypothermia to H2. (nih.gov)
  • Haemodilution and hypothermia induce coagulopathy separately, but their combined effect on coagulation has not been widely studied. (lu.se)
  • Furthermore, the removal of small blood volumes during the hemodilution process will not result in any economy of autologous blood from the patient [7,8]. (scirp.org)
  • In the study, Dr. Azriel Perel, Dr. Serban Bubenek, and colleagues at the Emergency Institute for Cardiovascular Diseases in Bucharest examined the effects of incremental fluid loading on oxygen delivery and on LabHb and SpHb as markers of possible iatrogenic hemodilution, which can necessitate blood transfusions that might otherwise be avoided. (ntbinfo.no)
  • Iatrogenic hemodilution: a possible cause for avoidable blood transfusions? (biomedcentral.com)
  • Fischer, E.G. and Ames III, A. (1972): Studies on mechanisms of impairment of cerebral circulation following ischemia: effect of hemodilution and perfusion pressure. (springer.com)
  • However, the second impact of miniature perfusion systems, the reduced priming volume with concomitant reduction in haemodilution, was not investigated with reference to inflammation. (strath.ac.uk)
  • Achieving a deep degree of hemodilution was not included in the objectives of the study authors, and hemodilution not considered as cervezeria technology. (russianpatents.com)
  • 3. The amount entered by the authors of the ringer's solution is 15 ml/kg, which is insufficient for achieving a deep degree of hemodilution. (russianpatents.com)
  • Few reliable measurements have been made, however, showing the effect of hemodilution on tissue oxygen tension. (elsevier.com)
  • H is concluded that the hemodilution resulted in a statistically but not clinically significant decrease in Scvo2 that was well tolerated by the patients as judged from hemodynamic responses as well as levels of arterial oxygen saturation (Sao2) and blood lactate. (lu.se)
  • Overall, 452 (26%) patients had evidence of hemodilution (≥4% absolute decrease in hematocrit). (ovid.com)
  • The researchers concluded, "Fluid loading as part of goal-directed therapy may cause a paradoxical decrease in DO 2 due to the development of iatrogenic hemodilution. (ntbinfo.no)
  • The development of iatrogenic hemodilution is reflected by a real-time decrease in the SpHb trend, which is similar to the intermittent LabHb trend. (ntbinfo.no)
  • Regional cerebral blood Bow decreased significantly in the left hemisphere after arterial ocdusion.This decrease was almost completely reversed by hemodilution except in the basal ganglia, where the increase in edema caused by hemodilution was the greatest. (elsevier.com)
  • There was a slight decrease in systemic arterial pressure with hemodilution but there were no significant changes in central venous pressure or in pulmonary arterial or wedge pressure. (elsevier.com)
  • There was a slight decrease in cardiac index in both the hemodilution and control groups, which may have been due to the effects of barbiturate anesthesia. (elsevier.com)
  • The researchers concluded, "In summary, our study shows that acute iatrogenic hemodilution does invariably occur after fluid administration, that it may lead to paradoxical decrease in DO 2 especially in 'nonresponders' and that its development is made visible by the continuous monitoring of SpHb when >500 mL of colloids are being administered. (aetoswire.com)
  • The average decrease in tHb during the blood removal and hemodilution procedure was 2.4 ± 0.8 g/dL (mean ± SD). (elsevier.com)
  • Preischemic hemodilution significantly attenuated myocardial damage as shown by lower release of cardiac troponin I and reduction in myocardial infarct size as measured by tetrazolin staining. (ovid.com)
  • Her thesis was on Myocardial Ischemia and the use of non-typing artificial blood in hemodilution. (wikipedia.org)
  • Myocardial blood flow and O2-supply following dextran-haemodilution and methaemoglobinaemia in the dog. (wikipedia.org)
  • This editorial will attempt to describe the frequent occurrence of iatrogenic hemodilution and its potential impact on decisions to transfuse blood. (biomedcentral.com)
  • The fluids used may be salt solutions but colloid solutions, which consist of large insoluble molecule meant to retain fluid intravascularly, are more effective as haemodilution agents. (cochrane.org)
  • In prospective clinical studies we investigated previously cardiovascular healthy adults during hyperoxemia, and during preoperative acute normovolemic hemodilution or early fluid resuscitation of severe burn victims. (diva-portal.org)
  • The effect of serial in vitro haemodilution with maternal cerebrospinal fluid and crystalloid on thromboelastographic (TEG(®) ) blood coagulation parameters, and the implications for epidural blood patching. (semanticscholar.org)
  • Low central venous pressure versus acute normovolemic hemodilution versus conventional fluid management for reducing blood loss in radical retropubic prostatectomy: a randomized controlled trial. (uams.edu)
  • Despite published guideline and consensus conference recommendations, the role of acute preoperative hemodilution in elective surgery has not been defined. (northwestern.edu)
  • We conclude that use of acute preoperative hemodilution remains in evolution and, as a single blood conservation intervention, contributes only modestly to blood conservation. (northwestern.edu)
  • Several clinical studies have demonstrated cerebral desaturation following hemodilution or blood loss ([FOOTNOTE=Torella F, McCollum CN. (medtronic.com)
  • In many countries, haemodilution has been used in clinical treatment of people with acute stroke since the 1970s. (cochrane.org)
  • Since then, a large number of clinical studies on haemodilution in acute stroke have been published. (cochrane.org)
  • However, the relationship between early post-discharge hemodilution, markers of congestion, and clinical outcomes is unknown. (ovid.com)
  • Acute normovolemic hemodilution: physiology, limitations, and clinical use. (bloodless.com.br)
  • Further studies are needed to examine the potential clinical benefit of SpHb monitoring in identifying acute hemodilution. (aetoswire.com)
  • In absence of customized hemodilution bags, this procedure is done by using ordinary single blood bag. (allindianpatents.com)
  • Patients with recent-onset CRVO (lasting for less than 1 month)are randomly assigned to one of 3 groups: hemodilution using erythrocytapheresis alone, 3 monthly injection of ranibizumab alone, or both. (clinicaltrials.gov)
  • Patients undergoing open-heart surgery who will be having acute normovolemic hemodilution (ANH) as part of their surgery. (clinicaltrials.gov)
  • Conclusions: In this large cohort of patients hospitalized for HF with reduced EF, early post-discharge hemodilution was associated with worsening congestion and higher mortality despite a lower risk of worsening renal function. (ovid.com)
  • Microcirculatory data were obtained by near-infrared spectroscopy from the brachioradial muscle in 20 consecutive patients undergoing hemodilution for CPB. (springermedizin.de)
  • Median whole blood volume and mean red blood cell (RBC) volume removed by hemodilution was 1000 mL (range, 400-1500 mL) and 338 mL (range, 156-585 mL), respectively, representing 15% of patients' admission RBC volume. (northwestern.edu)
  • Conclusion: Use of blood volume analysis in critically ill patients may help to distinguish true anemia from hemodilution, potentially preventing unnecessary interventions. (elsevier.com)
  • In comparison, 16 of 43 patients (37%) in the hemodilution group required transfussion. (elsevier.com)
  • nonhemodilution, 9.2/27.3), and postoperative day 2 (hemodilution in the 43 patients of this group. (elsevier.com)
  • Cell saver There were no complications related to the technique of hemodilution in the 43 patients of this group. (elsevier.com)
  • Cell saver was used in all patients, but sufficient volume to return blood to the patient was available in only 23 hemodilution patients (mean volume. (elsevier.com)
  • Acute normovolemic hemodilution is not beneficial in patients undergoing primary elective valve surgery. (bvsalud.org)
  • The objective of this study was to evaluate the effectiveness of acute normovolemic hemodilution (ANH) as a sole method of reducing allogenic blood requirement in patients undergoing primary elective valve surgery . (bvsalud.org)
  • A trial of acute normovolemic hemodilution reported in the latest issue of Annals of Surgery compares standard intraoperative management in patients undergoing major hepatic resection. (gastrohep.com)
  • Dr William Jarnagin and colleagues determined if acute normovolemic hemodilution, an established blood conservation technique, reduces the requirement for allogeneic red cell transfusions in patients undergoing major hepatic resection. (gastrohep.com)
  • The team prospectively randomized 130 patients, undergoing major hepatic resection to undergo either acute normovolemic hemodilution or standard anesthetic management. (gastrohep.com)
  • The researchers randomized 63 patients to acute normovolemic hemodilution, and 67 to standard anesthetic management from 2004 to 2007. (gastrohep.com)
  • Acute normovolemic hemodilution patients were less often transfused intraoperatively compared with the standard anesthetic management group. (gastrohep.com)
  • In patients with intraoperative blood loss 800 mL or more, acute normovolemic hemodilution reduced the proportion of patients requiring fresh frozen plasma. (gastrohep.com)
  • We sought to compare these variables during stepwise hemorrhage and hemodilution. (springeropen.com)
  • Here, the contribution of the erythropoietic and erythrophagocytic potential as well as of hemodilution to the development of T. congolense-induced anemia were addressed in a mouse model of low virulence relevant for bovine trypanosomosis. (vub.be)
  • Rather, anemia resulted from hemodilution. (vub.be)
  • Hemodilution studies have demonstrated that humans can tolerate anemia. (ccjm.org)
  • First, we focus on hemodilution studies that demonstrated that humans can tolerate anemia. (ccjm.org)
  • The aim of this study was to assess the pattern of adaptation to severe Haemodilution in pts with normal or stenotic carotid vessels. (elsevier.com)
  • Intracranial pressure increased significantly with time in all animals subjected to arterial occlusion, but this increase was less severe in the hemodilution group. (elsevier.com)
  • 2) in this acute model, SOD improved left ventricular systolic and diastolic functions and reduced infarct size further when given to the animals that had been treated with hemodilution. (iospress.com)
  • In order to demonstrate that hyponatraemia due to haemodilution occurs within the left ventricle following freshwater drowning, and to determine whether lysed blood resulting from left ventricular haemodilution may cause staining of the aortic intima, the following studies were undertaken. (edu.au)
  • Influence on hemodynamic change and tissue PO_2 response during hemodilution with hypotension. (nii.ac.jp)
  • Hemodynamic changes and tissue PO_2 response under acute hemodilution and controlled hypotension was studied in mongral dogs anesthetized with sevoflurane and paralized pancuronium. (nii.ac.jp)
  • 1. Pluse rate was sloght decreused after hemodilution, but should no changes during hypotension. (nii.ac.jp)
  • 2. CI significant incresed after hemodilution but should no significant changes during hypotension. (nii.ac.jp)
  • Time course of increased haemodilution in hypotension induced by extradural anaesthesia. (russianpatents.com)
  • Conclusions: Pulse CO-Oximetry-based SpHb measurement is accurate within 1.0 g/dL (1 SD) compared with laboratory CO-Oximeter tHb measurement in subjects undergoing hemodilution. (elsevier.com)
  • To determine the association between hemodilution and PSA concentration in obese men with prostate cancer. (nih.gov)
  • Hemodilution is the dilution of the concentration of red blood cells and plasma constituents by partially substituting the blood with colloids or crystalloids . (wikipedia.org)
  • To assess the effects of haemodilution in acute ischaemic stroke. (cochrane.org)
  • The increase in tissue oxygen tension we observed could in part explain the clinically beneficial effects of hemodilution. (elsevier.com)
  • In anesthetized and mechanically ventilated sheep ( n = 16), we compared the effects of progressive hemodilution and hemorrhage by means of expired gases analysis. (springeropen.com)
  • 3. Renal blood flow significantly increased after hemodilution. (nii.ac.jp)
  • On the one hand, the circulating blood volume and the degree of haemodilution generated at initiation of CPB is significantly higher in infants and young children, than older kids and adults. (nataonline.com)
  • Hemodilution significantly reduced viscosity, fibrinogen and total protein concentrations, and plasma oncotic pressure. (elsevier.com)
  • Systemic arterial blood pressure and pulmonary wedge pressure decreased slightly with hemodilution, but central venous pressure and pulmonary arterial pressure did not change significantly. (elsevier.com)
  • Specific gravity, measured just after the dogs were killed, 6 hours after hemodilution, was significantly lower in the white matter and basal ganglia of the left (ischemic) hemisphere in hemodiluted dogs than in controls. (elsevier.com)
  • One possible explanation for this outcome is that with higher levels of haemodilution, neutrophils have a greater opportunity to contact surface 'receptor' sites on the biomaterial, resulting in more neutrophil activation. (strath.ac.uk)
  • During acute normovolemic hemodilution, (ANH) blood subsequently lost during surgery contains proportionally fewer red blood cells per millimetre, thus minimizing intraoperative loss of the whole blood. (wikipedia.org)
  • final hematocrits after discrete blood volumes lost by surgery or by hemodilution were estimated. (northwestern.edu)
  • Hemodilution, hypotensive anesthesia, and cell saver were used in 43 children between June 1996 and July 1997, A comparison group (43 children) underwent similar surgery with hypotensive anesthesia and cell saver, but no hemodilution (between July 1995 and December 1996). (elsevier.com)
  • The main idea of this normo volumic hemodilution is that whatever blood is lost by the patient (during surgery) is diluted blood. (allindianpatents.com)
  • Thrombocytopenia caused by platelet destruction, hypersplenism, or hemodilution. (medlineplus.gov)
  • The isovolumetric hemodilution treatment reduces ischemic injury and anti‐radical interventions may reduce reperfusion injury. (iospress.com)
  • 3. Deep izovolemicescuu hemodilution (Ht reduction to 0.25%) is theoretically possible, however, rarely been used in practice, because exfuze large blood volume (1000 ml) in a patient can lead to hemodynamic instability, with the fall in systemic arterial pressure. (russianpatents.com)
  • In this study, we evaluated the accuracy of SpHb compared with laboratory CO-Oximeter measurement of tHb from arterial blood samples in 20 healthy volunteer subjects undergoing hemodilution. (elsevier.com)
  • Acute normovolemic hemodilution involves withdrawing blood and replacing it with crystalloid or colloid solution to maintain the volume. (ccjm.org)
  • Hemodilution beyond this point to lower hematocrits caused a steady decline in tissue oxygen tension. (elsevier.com)
  • Conclusion: The observed increase in tissue oxygen tension with hemodilution appears to be explained by a lesser reduction in capillary than in systemic hematocrit, coupled with an increased capillary blood now. (elsevier.com)
  • The normovolemic hemodilution is one of the various methods available to reduce (or to abolish) the use of homologous blood during elective surgeries. (bvsalud.org)
  • We wanted to compare the effectiveness of haemodilution (diluting the blood) treatment, started within 72 hours of stroke onset, versus control or no treatment in people with ischaemic stroke to assess the impact on death or dependence. (cochrane.org)
  • It is concluded that there is no clear scientific support for the use of haemodilution in the routine treatment of people with acute ischaemic stroke. (cochrane.org)
  • The overall results of this review showed no clear evidence of benefit of haemodilution therapy for acute ischaemic stroke. (cochrane.org)
  • These results are compatible with no persuasive beneficial evidence of haemodilution therapy for acute ischaemic stroke. (cochrane.org)
  • Randomised trials of haemodilution treatment in people with acute ischaemic stroke. (cochrane.org)