Hematopoietic stem cell transplant cell transplantation. Medical search

4.8 If haematopoietic stem cell transplantation (HSCT) is urgent and there are no suitable available donors, assess risk and liaise with the registry. (nice.org.uk)
Transplantation of HSC (HSCT) is done in order to re-establish bone marrow and immune system function after being damaged and/or attacked by blood cancer. (thedailystar.net)
The most common indications for HSCT are blood cancers, mainly acute leukaemia, cancers of the lymphatic tissues (lymphomas) and the antibody-forming blood cells (multiple myeloma). (thedailystar.net)
HSCT can be broadly divided into autologous transplantation, where patients use their own blood stem cells, and allogeneic transplantation, where stem cells are obtained from a different person. (thedailystar.net)
Hematopoietic stem-cell transplantation ( HSCT ) is the transplantation of multipotent hematopoietic stem cells , usually derived from bone marrow , peripheral blood , or umbilical cord blood . (wikipedia.org)
The spectrum of target antigens associated with tumor immunity and alloimmunity after allogeneic HSCT: Host-derived T and B cells can be induced to recognize tumor-associated antigens, whereas donor-derived B and T cells can recognize both tumor-associated antigens and alloantigens. (wikipedia.org)
Autologous HSCT requires the extraction ( apheresis ) of hematopoietic stem cells (HSCs) from the patient and storage of the harvested cells in a freezer. (wikipedia.org)
In this study, we sought to describe characteristics, risk factors, and outcomes of Rhodococcus infection among solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients in the United States. (cdc.gov)
Median time from transplant to infection was 5 (range 2-54) for HSCT recipients and 28 (range 3-237) months for SOT recipients. (cdc.gov)
The purpose of this research study is to perform a serial analysis of immune function using blood cells and sera obtained from patients after vaccination following hematopoietic stem cell transplantation (HSCT). (clinicaltrials.gov)
While innate immunity (myeloid and NK cell) is restored relatively quickly following HSCT, a prolonged period of lymphopenia occurs in all patients. (clinicaltrials.gov)
In children who have received chemotherapy and HSCT, T cell function generally recovers within 6 to twelve months. (clinicaltrials.gov)
There are many studies that correlate decreased T cell number and function (specifically CD4+ T cells) with an increase in post-transplant infections and relapse has been shown to be inversely proportional to T cell reconstitution following both autologous and allogeneic HSCT. (clinicaltrials.gov)
Omeros Corporation (Nasdaq: OMER) today announced positive data from its pivotal clinical trial of the company's novel investigational complement inhibitor narsoplimab in the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA), a frequently lethal complication of HSCT. (bioportfolio.com)
Acute graft-versus-host disease (aGVHD) is the most frequent and severe complication after allogeneic hematopoietic stem cell transplantation (HSCT). (scirp.org)
Supportive care guidelines recommend anti-mold prophylaxis in hematopoietic stem cell transplant (HSCT) recipients deemed high-risk for invasive fungal infection, leading to long-term use of voriconazole following allogeneic HSCT in patients that remain immunocompromised. (fluoridealert.org)
Voriconazole has been associated with periostitis, exostoses, and fluoride excess in patients following solid organ transplant, HSCT and leukemia therapy. (fluoridealert.org)
On the other hand, reduced intensity regimens have allowed for HSCT in patients not previously eligible for transplant due to poor overall functional status, uncontrolled infection or poor organ function. (renalandurologynews.com)
Hematopoietic stem cell transplantation (HSCT) or Bone marrow transplantation is a medical procedure in the field of hematology and oncology that involves transplantation of hematopoietic stem cells (HSC). (citizendium.org)
Autologous HSCT involves isolation of HSC from a patient, storage of the stem cells in a freezer, high-dose chemotherapy to eradicate the malignant cell population at the cost of also eliminating the patient's bone marrow stem cells, then return of the patient's own stored stem cells to their body. (citizendium.org)
The objective is to find out the causes of Cytopenia post-engraftment (CPE) in hematopoietic stem cell transplantation (HSCT) for patients with β-thalassemia major (β-TM). (sciencepg.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) is the preferred curative therapy for children with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). (bvsalud.org)
Of the 12 patients who received HSCT, one died of a transplant-related cause, one died of relapse after HSCT, and 10 remain in continuous CR. (bvsalud.org)
Hematopoietic stem cell transplantation (HSCT) is an established procedure for many acquired and congenital disorders of the hematopoietic system, including disorders of the immune system, and as enzyme replacement in metabolic disorders. (gaselectricity.in)
Origin electricity faults 1, 2, 3, 4 The annual activity survey of the European Society of Blood and Marrow Transplantation (EBMT), describing the status of HSCT in Europe and affiliated countries, has become an instrument used to observe trends and to monitor changes in technology use. (gaselectricity.in)
Gas and supply okc 13 The analysis of the survey data spanning over 20 years has shown a continued and constant increase in the annual numbers of HSCT and transplant rates (number of HSCT per 10 million inhabitants) for both allogeneic and autologous HSCT. (gaselectricity.in)
Electricity prices going up In addition to transplant rates and indications, this report focuses on the use of donors other than HLA identical siblings and matched unrelated donors for allogeneic HSCT. (gaselectricity.in)
Electricity joules Their data (2716 HSCT) from 30 actively transplanting teams makes up 6.7 % of the total data set and are included in all analyses. (gaselectricity.in)
Gas mask bong nfl Unrelated donor transplants include HSCT from unrelated donors with peripheral blood and marrow as a stem cell source but not cord blood HSCT, these are shown as cord blood HSCT in Figure 3a. (gaselectricity.in)
Multiple transplants may include multiple transplants defined as subsequent transplants within a planned double or triple autologous or allogeneic transplant protocol, and retransplants (autologous or allogeneic) defined as unplanned HSCT for rejection or relapse after a previous HSCT. (gaselectricity.in)
Transplant rates, defined as the total number of HSCT per 10 million inhabitants, were computed for each country without adjustments for patients who crossed borders and received their HSCT in a foreign country. (gaselectricity.in)
We sought to determine whether enzyme replacement therapy (ERT) with iduronidase in the peritransplant period affects outcome of hematopoietic stem cell transplantation (HSCT) for MPS IH. (nature.com)
The first experience with hematopoietic stem cell transplantation (HSCT) as therapy for Hurler was reported by Hobbs, 8 and since that time HSCT has been accepted as the standard of care for patients with MPS IH, as this results in engraftment of cells within the brain, providing enzyme to the central nervous system, halting neurocognitive decline. (nature.com)
While outcomes after HSCT have improved with the availability of improved methods for stem cell graft typing and supportive care, concerns remain regarding the toxicity of transplantation. (nature.com)
Patients who undergo pediatric Hematopoietic Stem Cell Transplantation (HSCT) may experience long-term psychological sequelae and poor Quality of Life (QoL) in adulthood. (frontiersin.org)
0.05) associated with specific socio-demographic and medical variables (gender, type of pathology, type of HSCT, time elapsed between communication of the need to transplant and effective transplantation, and days of hospitalization). (frontiersin.org)
The NCD for Stem Cell Transplantation Multiple Myeloma (MM), Myelofibrosis (MF) and Sickle Cell Disease (SCD), released by CMS on January 27, 2016, concluded that, CMS will cover items and services necessary for research under §1862(a)(1)(E) for a allogeneic hematopoietic stem cell transplant (HSCT) for certain Medicare beneficiaries with myelofibrosis (MF) using the Coverage with Evidence Development (CED) paradigm. (cms.gov)
Allogeneic HSCT for sickle cell disease (SCD) will be covered by Medicare only for beneficiaries with severe, symptomatic sickle cell disease who participate in an approved prospective clinical study. (cms.gov)
Pure red cell aplasia (PRCA) is a rare but well-recognized immunohematological complication that occurs in the setting of major ABO-incompatible hematopoietic stem cell transplant (HSCT). (nature.com)
The aim of this work was to analyse the incidence and severity of infections and mortality in relation to the MBL2 genotype and MBL levels in patients underwent allogeneic haematopoietic stem cell transplantation (Allo-HSCT). (unican.es)
Conclusions: Patients who underwent Allo-HSCT with low pre-transplant MBL levels presented the first episode of infection earlier and had an increased risk of viral infections and mortality in the first 6 months post-transplant. (unican.es)
Haematopoietic stem cell transplantation (HSCT) is a highly specialised procedure used to treat malignancies of the lymphohaematopoietic system as well as some acquired and inherited disorders of the blood. (smw.ch)
Haematopoietic stem cell transplantation (HSCT) has become an established treatment option for a wide range of haemato-oncological tumours, some solid tumours, and nonmalignant diseases such as bone marrow failure, primary immunodeficiencies and other congenital and acquired disorders [1- (smw.ch)
The haematopoietic system is replaced in the form of haematopoietic stem cells from either the patients themselves (autologous HSCT) or other persons (allogeneic HSCT). (smw.ch)
Autologous HSCT is used to bridge haematopoietic failure during high-dose chemotherapy for the treatment of tumours of the haematopoietic system and some solid tumours that are adequately sensitive to this treatment. (smw.ch)
Allogeneic HSCT is used to replace the haematopoietic system in patients with acquired or congenital haematopoietic failure, and more commonly to exploit the graft versus tumour effect of allogeneic cells in malignant disease [1- (smw.ch)
Historically, in allogeneic HSCT marrow-ablative doses of chemotherapy and total-body irradiation were thought to be necessary to eradicate malignancy, to provide immunosuppression in the recipient, and to create space in the stem cell compartment, allowing engraftment of donor haematopoietic cells. (smw.ch)
The reduction in toxicity with RIC results in less morbidity and mortality, and has made allogeneic HSCT available to patients with comorbidities and to older patients (i.e., patients aged 60 to 70 years, the age group that has the highest prevalence of most haematopoietic malignancies). (smw.ch)
It is important to note, however, that while the United States Food and Drug Administration (FDA) have approved hematopoietic stem cell transplantation (HSCT) for use against cancer , it is not yet approved for wider use. (medicalnewstoday.com)
Allogeneic HSCT requires a donor to supply suitable stem cells. (medicalnewstoday.com)
Autologous HSCT avoids the issue of trying to find a matching donor because stem cells are harvested from the patients themselves. (medicalnewstoday.com)
In this database of 530 patients who received allo-HSCT between 1990 and 2017, 15 developed solid cancers with a median interval of 3487 days after transplantation. (springer.com)
3 Hematopoietic allogeneic stem cell transplantation (HSCT) has the potential to cure PKD. (haematologica.org)
In order to achieve this goal queries were sent to national and international databanks, including the European Society for Blood and Marrow Transplantation (EBMT), the Center for International Blood and Marrow Transplant Research (CIBMTR), and the National Institute of Health (NIH), as well as to physicians known to be involved in HSCT in PKD patients. (haematologica.org)
Albany, NY -- ( SBWIRE ) -- 05/11/2017 -- The competitive landscape in the global market for hematopoietic stem cell transplantation (HSCT) is characterized by the rivalry between the leading market players, such as Regen Biopharma Inc., Cryo-Save AG, Pluristem Therapeutics Inc., and CBR Systems Inc., finds a new research study by Transparency Market Research (TMR). (sbwire.com)
Get accurate market forecast and analysis on the Global Hematopoietic Stem Cell Transplantation (HSCT) Market. (sbwire.com)
This two (2) day program is designed for Registered Nurses and Nurse Practitioners caring for patients undergoing Hematopoietic Stem Cell Transplantation (HSCT). (mskcc.org)
6 We describe herein a case of coinfection due to S. stercoralis and CMV in a patient who underwent allogeneic hematopoietic stem-cell transplantation (allo-HSCT) for HTLV-1-associated peripheral T-cell lymphoma. (lww.com)
A 60-year-old woman originally from Jamaica with HTLV-1-associated peripheral T-cell lymphoma presented 62 days post-allo-HSCT, with a 2-day history of epigastric pain and diarrhea. (lww.com)
The most established stem cell medical treatment is hematopoietic stem cell transplantation (HSCT) therapy. (regmednet.com)
Recognizing this challenge to estimating rates of HSCT graft failure, the current best estimate is about 5% overall, based in part on the need for second and even third transplants in treated patients (Wolff, 2002). (regmednet.com)
2013). However, surprisingly, HSCT continues to be practiced around the world without the benefit of knowing the dose of HSCs transplanted. (regmednet.com)
So, amazingly, although the dose of transplanted HSCs is one of the most important factors for success in HSCT, this metric is barely mentioned in tens of thousands of reports on HSCT biomedical research that span nearly a half-century. (regmednet.com)
Standardized minimal levels for CD34 cell and TNC counts have been established to keep graft failure rates in the range of 1-5%, even with cord blood HSCT (Rich, 2015). (regmednet.com)
Depression, fatigue, and pain are prevalent and distressing quality of life concerns for individuals recovering from hematopoietic stem cell transplantation (HSCT). (aacrjournals.org)
The ZOE-HSCT study succeeded in its primary objective by demonstrating an efficacy of 68.17% [95%CI: 55.56 - 77.against shingles in subjects above 18 years of age after receiving an autologous haematopoietic stem cell transplant. (gsk.com)
Although haematopoietic stem cell transplant (HSCT) recipients have an increased risk of infection, as a result of severe cellular immunity suppression, Mycobacterium tuberculosis infections are rare. (ecancer.org)
We present a case of tuberculosis (TB) reactivation after an allogeneic HSCT with isolated lymph node involvement, which mimics other post-transplant complications and makes the diagnosis difficult. (ecancer.org)
This study examines the short- and long-term QOL benefits of a music therapy intervention for patients recovering from hematopoietic stem cell transplantation (HSCT). (hindawi.com)
Hematopoietic stem cell transplantation (HSCT) is a medically complex modality that can offer a chance of cure to children with both malignant and nonmalignant conditions. (dana-farber.org)
and provide updates on important viral infections after hematopoietic stem cell transplant (HSCT). (mdpi.com)
In contrast, HHV6-associated encephalitis is an emerging syndrome in transplant recipients, especially those undergoing allogeneic hematopoietic stem-cell transplantation (HSCT). (ajnr.org)
Chronic myeloid leukemia is a myeloproliferative disorder that may be treated with hematopoietic stem cell transplantation (HSCT). (hindawi.com)
Cases of donor-derived acute myeloid leukemia (AML) or MDS after HSCT or solid tumor transplantation have been published. (hindawi.com)
Determine the feasibility of maintaining optimal ART in HIV-1 infected patients during allogeneic hematopoietic stem cell transplant (HSCT). (knowcancer.com)
Recently, MN has been considered to be a possible presentation of chronic graft-versus-host disease (GVHD) of the kidney in allogeneic hematopoietic stem cell transplantation (HSCT) patients. (biomedcentral.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) reverses the bone marrow failure syndrome due to GATA2 deficiency. (unboundmedicine.com)

We conducted a case-control study of 18 US transplant recipients with Rhodococcus infection and 36 matched controls. (cdc.gov)
Our knowledge of disease characteristics among transplant recipients is limited to case reports ( 3 - 8 ). (cdc.gov)
With the increase in organ transplantation and improved survival of transplant recipients, the incidence of disease will likely increase in the coming years. (cdc.gov)
BO has been studied most extensively in lung transplant recipients, where it is considered to represent chronic lung rejection. (clinicaltrials.gov)
Anti-Pneumocystis Prophylaxis to Prevent Nocardia Infection in Hematopoietic Stem Cell Transplant Recipients. (bioportfolio.com)
Transplant Recipients. (bioportfolio.com)
We read with interest the recent paper by Molina and coworkers, who studied the relationship between anti-Pneumocystis prophylaxis and Nocardia infections in allogeneic hematopoietic stem cell transplant recipients. (bioportfolio.com)
Pneumocystis jirovecii pneumonia prophylaxis in allogeneic hematopoietic cell transplant recipients: can we always follow the guidelines? (bioportfolio.com)
Pneumocystis jirovecii pneumonia (PCP) is a life-threatening disease in allogeneic hematopoietic cell transplantation (HCT) recipients. (bioportfolio.com)
Infection is the leading cause of morbidity and mortality in immunocompromised patients such as hematopoietic/solid organ transplant recipients and individuals with human immunodeficiency virus. (nih.gov)
Recipients of stem cell transplants may be severely immunocompromised for many months after transplantation, especially if they are still taking immunosuppressive drugs. (cmaj.ca)
In this article we aim to familiarize primary care practitioners with some of the basics of allogeneic and autologous transplantation, as well as issues relevant to the care of transplant recipients over the short and the long term. (cmaj.ca)
What is the clinical significance of positive blood cultures with Aspergillus sp in hematopoietic stem cell transplant recipients? (nih.gov)
HLA-haploidentical transplantation utilizing post-transplant cyclophosphamide achieves comparable survival to HLA-matched transplantation and has thereby expanded the option of allogeneic transplantation to the vast majority of eligble recipients. (springer.com)
In this review, we discuss the incidence of respiratory syncytial viral infections, risk factors associated with progression from upper respiratory tract infection to lower respiratory tract infection, other complications and outcomes (including mortality), management strategies, and prevention strategies in patients with a hematologic malignancy and in hematopoietic cell transplant recipients. (haematologica.org)
The outcomes of these infections vary on the basis of the patient population, with adverse outcomes having been described in hematopoietic cell transplant (HCT) recipients and patients with a hematologic malignancy (HM). (haematologica.org)
2,3 Furthermore, recipients have a higher nonrelapse mortality if CMV reactivation occurs less than 100 days after transplantation. (hematology.org)
Despite these advances, several studies have shown that recipients who are CMV-seropositive remain at risk for worse OS and increased transplant-related mortality. (hematology.org)
Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients. (webmd.com)
Cyclosporine dose reduction by ketoconazole administration in renal transplant recipients. (webmd.com)
Increased cyclosporine levels as a result of simultaneous fluconazole and cyclosporine therapy in renal transplant recipients: a double- blind, randomized pharmacokinetic and safety study. (webmd.com)
At the forefront of research to increase access to hematopoietic stem cell transplantation and improve outcomes, the Center has amassed a clinical database containing information on nearly 350,000 transplant recipients. (ascopost.com)
PTLD developed in 78 recipients, with 64 cases occurring less than 1 year after transplantation. (semanticscholar.org)
Of the 48 cell lines they created, 14 had activity in the lab against all five viruses and, importantly, none showed alloreactivity against the recipients, Leen and colleagues reported. (medpagetoday.com)
Participants (24 allogeneic and 68 autologous transplant recipients) completed well-validated measures of depressive symptoms, fatigue, and pain prior to transplant and 30, 100, and 200 days post-transplant. (aacrjournals.org)
Results indicated that depression and fatigue were most severe 30 days post-transplant, with allogeneic recipients showing markedly slower improvement than autologous recipients at later assessments. (aacrjournals.org)
The immune systems of these stem cell transplant recipients is substantially weakened compared to the general older adult populations studied in other Shingrix efficacy trials," Emmanuel Hanon, Senior Vice President and Head of Vaccines R&D for GSK said. (gsk.com)
Dr. Knight's research program aims to investigate biological risk and interventions - both pharmacologic and behavioral - for social health disparities in cancer, specifically among hematopoietic stem cell transplant (HCT) and cellular therapy recipients. (mcw.edu)
Optimizing the prevention and management of infectious diseases by using the best available evidence will contribute to better outcomes for stem cell transplant recipients, and provide the best possible "safety net" for these immunocompromised hosts. (mdpi.com)
But to keep the body's immune system from rejecting the transplant, recipients must take drugs that suppress their immune system for the rest of their lives. (roche.com)
HRD recipients received high-dose post-transplant cyclophosphamide (PTCy) followed by tacrolimus and mycophenolate mofetil. (unboundmedicine.com)

4.4 For cryopreservation donations, test for COVID‑19 at the assessment and again at harvest of stem cells or donor lymphocytes. (nice.org.uk)
In the case of transplants using HSC derived from other people, the conditioning therapy also helps reduce the risk of the recipient's body killing or rejecting the incoming donor stem cells (graft rejection). (thedailystar.net)
Accurate determination of immune system compatibility is vital to minimise graft failure and lethal attack from donor cells against recipient's normal tissues (graft-versus-host disease or GvHD). (thedailystar.net)
In the case of allogeneic transplant, the patient's donor will also have to undergo an assessment. (thedailystar.net)
In 2014, according to the World Marrow Donor Association , stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). (wikipedia.org)
The usual odds ratio is 1 out of 100 CBUs that meet donor-recipient eligibility/match criteria and are transplanted. (frontiersin.org)
Cord blood units, unlike adult donor stem cell collection/harvests, are readily available on demand. (frontiersin.org)
The choice between the more risky allogeneic transplant and an autologous procedure depends on patient age, the underlying disease, donor availability and institutional preference ( Box 1 ). (cmaj.ca)
Allogeneic transplantation represents 40% of all stem cell transplants performed annually in Canada and requires donor and recipient matching for major histocompatibility (HLA) antigens. (cmaj.ca)
Blood stem cell transplantation is accomplished by treating the donor with hematopoietic growth factors, which cause the stem cells to proliferate and circulate freely in the peripheral blood. (cmaj.ca)
Fig. 1: Collection of stem cells by direct aspiration from bone marrow, with the donor under general anesthetic. (cmaj.ca)
and (2) allogeneic (patient receives healthy donor bone marrow, peripheral blood stem cells or umbilical cord/placental blood to restore normal marrow/immune function where it is deficient, allow otherwise potentially lethal intensive anti-cancer treatment, and provide alloreactivity that may eliminate minimal residual malignant disease). (renalandurologynews.com)
Collecting stem cells provides a bigger graft, and does not require that the donor be subjected to general anesthesia to collect the graft. (citizendium.org)
To avoid rejection of the transplanted stem cells or severe graft-versus-host disease , the donor should have the same human leukocyte antigens (HLA) as the recipient. (citizendium.org)
When added to the standard drug regimen used to prevent GVHD, abatacept reduced the occurrence of acute, grade III-IV GVHD from 32% to 3% in pediatric and adult patients who underwent mismatched unrelated donor stem cell transplants to treat advanced cancer and other blood disorders. (ascopost.com)
For patients receiving cells from an unrelated donor, the rate of mild-to-severe forms of acute GVHD can reach as high as 80%, with up to half of patients dying from the most severe forms. (ascopost.com)
In their models, abatacept reduced the proliferation and activation of effector T cells, which incite GVHD when they become overactive as the patient's immune system starts to rebuild itself from the donor stem cells. (ascopost.com)
A study by MacMillan et al reported that alternative donor hematopoietic cell transplantation had a high success rate in patients with Fanconi anemia who did not have a history of opportunistic infections or transfusions and who underwent conditioning with single fraction total body irradiation 300 cGy, cyclophosphamide, fludarabine, and antithymocyte globulin. (medscape.com)
A study by Wang et al suggested that in patients with Fanconi anemia, the 1-year overall survival rate following unrelated-donor hematopoietic stem cell transplantation is poor in those with clonal or complete copy gains in the q arm of chromosome 3 or with abnormalities in three or more chromosomes. (medscape.com)
The effect of pre-transplant ferritin (PTF) and recipient and donor age on CPE were analyzed in the two groups. (sciencepg.com)
Haploidentical stem cell transplantation (haploSCT) from a first-degree-related haplotype-mismatched donor (siblings, children, parents) could expand allogeneic stem cell transplantation (SCT) to a large proportion of patients with hematologic malignancies without an HLA-matched donor ( 1 ). (mhmedical.com)
In contrast to unrelated donor stem cells, haploidentical (or "half-matched") donors can be available immediately, and there are no costs associated with an unrelated donor search, maintaining a registry, or coordinating logistics with distant donor centers. (mhmedical.com)
This approach might also be particularly useful in developing countries that may not have the resources to procure unrelated donor transplants or maintain complex unrelated donor registries. (mhmedical.com)
Moreover, haploidentical donors offer the possibility to easily collect donor cells for cellular therapy posttransplant. (mhmedical.com)
Improved haploidentical transplant outcomes represent a major advance in SCT that has practically eliminated the limitation of donor availability for allogeneic SCT. (mhmedical.com)
Effector T cells incite GvHD when they become overactive as the patient's immune system starts to rebuild itself from the donor stem cells. (seattlechildrens.org)
The second cohort of 140 patients with human leukocyte antigen-matched unrelated donor transplants completed enrollment in November 2017, with data expected from this randomized double-blind arm of the study in the next six months. (seattlechildrens.org)
There must be appropriate statistical techniques in the analysis to control for selection bias and potential confounding by age, duration of diagnosis, comorbid conditions, type of preparative/conditioning regimen, graft vs. host disease (GVHD) prophylaxis, donor type and cell source. (cms.gov)
We report a case of PRCA following a matched sibling donor allogeneic PBSC transplant (PBSCT) with a bidirectional ABO mismatch. (nature.com)
He had uneventful engraftment of neutrophils and platelets, with absolute neutrophil and platelet count's exceeding 0.5 × 10 9 and 20 × 10 9 /L on D+13 and D+19, respectively, and a 100% donor chimerism at 1 month post transplant. (nature.com)
These data are put in correlation with donor availability from international registries and with number of transplant teams and number of procedures per team all corrected for population size. (smw.ch)
He has an HLA-matched related donor (his brother) who agrees to donate hematopoietic cells for an allogeneic transplant. (hematology.org)
and 2) the donor cells did not have the delta 32 mutation that results in CD4 receptors that are CCR5 negative in new cells (conferring resistance to re-infection by HIV). (healio.com)
It is interesting the investigators hypothesize that following the allogeneic bone marrow transplants that graft vs host disease (ie, donor cells killing host cells), in combination with ongoing ART, led to the potential eradication of HIV in these two patients. (healio.com)
The Berlin patient, who was the first reported case of cure, received a form of gene therapy by receiving a bone marrow transplant from a donor with a favorable genetic mutation. (healio.com)
The Center for International Blood and Marrow Transplant Research is a combined research program of the National Marrow Donor Program and the Medical College of Wisconsin, Milwaukee. (ascopost.com)
New reduced-intensity preparative regimens cause considerably less morbidity and mortality, but are still sufficiently immunosuppressive to allow donor cells to engraft. (ascopost.com)
And we are able to do alternative-donor transplants with an acceptable rate of graft-vs-host disease and transplant-related mortality. (ascopost.com)
For people needing an organ transplant, testing provides essential information about the urgency of the need for the organ, the patient's blood and tissue type, and body size - this data helps the donor computer programme find the best match. (roche.com)
CMV testing plays a vital role for both the patient needing the transplant and the donor. (roche.com)
When a donor organ becomes available, another CMV test takes place hours before surgery so that the transplant team has the most current information about the patient's CMV status. (roche.com)
The pre-transplant test is a blood (serology) test that identifies whether the donor or patient receiving the transplant has already been infected with CMV and provides information about the level of potential risk to the recipient from the virus (see chart). (roche.com)
Stem cells are removed from another person, called a donor. (medlineplus.gov)
Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
The red blood cells are returned to the donor. (medlineplus.gov)
Further insight into humoral viral immunity after hematopoietic cell transplantation (HCT) could have potential impact on donor selection or monitoring of patients. (bloodjournal.org)
While posttransplantation relapse of disease resulting from a failure to eradicate the patient's original leukemia could occur, patients may also rarely develop a secondary malignancy or myelodysplastic syndrome (MDS) of donor origin termed donor cell leukemia (DCL). (hindawi.com)
However, patients may also rarely develop a secondary malignancy or myelodysplastic syndrome of donor origin termed donor cell leukemia (DCL) [ 3 ]. (hindawi.com)
Posttransplantation donor-derived multiple myeloma is an exceedingly rare phenotype of DCL that has been reported following solid organ transplantation of the heart, lungs, and kidneys [ 5 - 7 ]. (hindawi.com)
Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK deficiency. (cancer.gov)
Haploidentical related donor hematopoietic stem cell transplantation for DOCK8 deficiency using post-transplant cyclophosphamide. (cancer.gov)
The BMDW Editorial Board consists of one representative of each stem cell donor registry or cord blood bank participating in BMDW, and meets twice a year to discuss achievements and necessary improvements. (wikipedia.org)
BMDW participants consist of 75 hematopoietic cell donor registries from 53 countries, and 53 cord blood banks from 36 countries. (wikipedia.org)
Search & Match tool: The BMDW provides a fast preliminary search tool to find the best matched stem cell donor or cord blood unit for a patient in need of a transplant. (wikipedia.org)
The tool is primarily intended for use by professionals in the field of stem cell transplantation with profound knowledge of HLA, such as search coordinators and transplant physicians from transplant centres, stem cell donor registries, and cord blood banks. (wikipedia.org)
BMDW's mission is to create a comprehensive, fair, and equitable global list of unrelated stem cell donors and cord blood products that shall allow fast determination of whether a matched donor is available for a patient in need of a hematopoietic stem cell transplant. (wikipedia.org)

Biol Blood Marrow Transplant. (springer.com)

For the journal abbreviated Bone Marrow Transplant , see Bone Marrow Transplantation (journal) . (wikipedia.org)
In 2006, 50,417 first HSCTs were recorded worldwide, according to a global survey of 1,327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
The Worldwide Network for Blood and Marrow Transplantation reported the millionth transplant to have been undertaken in December 2012. (wikipedia.org)
In 2006 a total of 50,417 first hematopoietic stem cell transplants were reported as taking place worldwide, according to a global survey of 1327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
Bone marrow transplantation was first attempted, albeit unsuccessfully, in 1939, when human bone marrow cells were injected intravenously to treat a patient with aplastic anemia. (cmaj.ca)
Bone marrow transplantation was pioneered at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s by E. Donnall Thomas , whose work was later recognized with a Nobel Prize in Physiology and Medicine. (citizendium.org)
A major limitation of allogeneic bone marrow transplantation is a shortage of donors. (citizendium.org)
Hemopoietic stem cell transplantation in thalassemia: a report from the European Society for Blood and Bone Marrow Transplantation Hemoglobinopathy Registry, 2000-2010. (sciencepg.com)
When given on days 3 and 4 after HLA-haploidentical T-cell replete blood or marrow transplantation, high-dose cyclophosphamide depletes dividing alloreactive T-cells, resulting in low rates of acute graft -versus- host disease, comparable to HLA-matched transplantation, and chronic graft -versus- host disease incidence below that seen with T-cell replete HLA-matched transplantation. (springer.com)
Mismatched family donors for bone-marrow transplantation as treatment for acute leukaemia. (springer.com)
Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma. (springer.com)
Marrow transplantation from related donors other than HLA-identical siblings. (springer.com)
Solid cancers after bone marrow transplantation. (springer.com)
Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study. (semanticscholar.org)
We evaluated 18,014 patients who underwent allogeneic bone marrow transplantation (BMT) at 235 centers worldwide to examine the incidence of and risk factors for posttransplant lymphoproliferative disorders (PTLD). (semanticscholar.org)
Real-World Issues and Potential Solutions in Hematopoietic Cell Transplantation during the COVID-19 Pandemic: Perspectives from the Worldwide Network for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research Health Services and International Studies Committee. (dana-farber.org)
Biol Blood and Marrow Transplantation. (cancer.gov)
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, vol. 24, no. 6, 2018, pp. 1250-1259. (unboundmedicine.com)

Is There Any Reason to Prefer Cord Blood Instead of Adult Donors for Hematopoietic Stem Cell Transplants? (frontiersin.org)
Allogeneic transplant donors may be related (usually a sibling) or unrelated volunteers. (citizendium.org)
In the cohort of patients who received transplants from mismatched unrelated donors, all 43 patients received four doses of abatacept with a calcineurin inhibitor and methotrexate. (ascopost.com)
Related transplant donors must be proven not to have Fanconi anemia in order for a transplantation to succeed. (medscape.com)
The survival rate after transplantation from alternative donors is improving, depending on the completeness of the HLA-matching. (medscape.com)
Partially HLA-mismatched related (HLA-haploidentical) donors can be identified for the vast majority of patients, but transplants from these donors have historically been limited by excessive graft -versus- host disease, nonrelapse mortality, and poor overall survival. (springer.com)
Results of allogeneic bone marrow transplants for leukemia using donors other than HLA-identical siblings. (springer.com)
Differences in transplant rates, in rates for particular indications, and in the use of specific transplant technologies such as use of unrelated donors, use of cord blood or mismatched family donors are described. (smw.ch)
Significant improvement in survival after allogeneic hematopoietic cell transplantation during a period of significantly increased use, older recipient age, and use of unrelated donors. (springer.com)
The two patients had received reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation from wild-type CCR5 donors. (healio.com)
This is particularly true in the area of allogeneic transplantation, where the major barriers to widespread use were the toxicity associated with high-dose chemotherapy and radiation given beforehand, and the high risk of graft-vs-host disease, especially when using donors other than human leukocyte antigen (HLA)-identical siblings. (ascopost.com)
The number of viruses recognized by a given cell line was correlated with the donors' age, they reported, possibly a reflection of exposure to a larger number of pathogens in older donors. (medpagetoday.com)
Bone Marrow Donors Worldwide (BMDW) is an organization based in Leiden, Netherlands, that coordinates the collection of the HLA phenotypes and other relevant data of volunteer hematopoietic cell donors (used to perform what used to be called bone marrow transplants, but now referred as hematopoietic cell transplants) and cord blood units across the globe. (wikipedia.org)
Joining BMDW database requires a registry to be fully operational, and must have at least 50 HLA-typed unrelated stem cell donors or cord blood units. (wikipedia.org)
The BMDW is the world's largest hematopoietic cell database, listing more than 29.5 million stem cell donors and over 721,289 cord blood units. (wikipedia.org)
These global hematopoietic cells from donors or cord blood units are used to transplant patients around the world with a variety of with life-threatening blood disorders such as leukemia, lymphoma, aplastic anemia, as well as certain immune system and metabolic disorders. (wikipedia.org)
The purpose of BMDW still remains the same, to collect the HLA phenotypes of volunteer stem cell donors and cord blood units and to co-ordinate their worldwide distribution. (wikipedia.org)

Other conditions treated with stem cell transplants include sickle-cell disease , myelodysplastic syndrome , neuroblastoma , lymphoma , Ewing's sarcoma , desmoplastic small round cell tumor , chronic granulomatous disease , Hodgkin's disease and Wiskott-Aldrich syndrome . (wikipedia.org)
Other conditions that bone marrow transplants are considered for include thalassemia major , sickle-cell disease , myelodysplastic syndrome , lymphoma , Hodgkin's disease , and multiple myeloma . (citizendium.org)
They also allow us to consider transplantation in other disorders where high transplant-related mortality rates were previously considered prohibitive-for example, in people with severe sickle cell disease or autoimmune disease. (ascopost.com)

Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide. (dana-farber.org)

How to Improve Cord Blood Transplantation: By Enhancing Cell Counts or Engraftment? (frontiersin.org)
Efforts to increase stem cell content or engraftment rate of the graft by ex vivo expansion, modulation by molecules such as fucose, prostaglandin E2 derivative, complement CD26 inhibitors, or CXCR4/CXCL12 axis have been able to accelerate engraftment speed and rate. (frontiersin.org)
7 The use of blood stem cells is associated with faster recovery of neutrophils and platelets after transplantation (engraftment) than is the case with bone marrow stem cells. (cmaj.ca)
This section describes the 4 components of allogeneic transplantation - conditioning, transplantation, engraftment and immunoreconstitution ( Fig. 2 ) - and provides information about the patient's hospital stay and the risks associated with this type of transplantation. (cmaj.ca)
The study, which involved 130 patients, also found that adding fludarabine to conditioning caused three-fold enhancement of hematopoietic cell engraftment. (medscape.com)
2 Delivery of α- L -iduronidase may be achieved by either the exogenous administration of α- L -iduronidase or through the endogenous production of α- L -iduronidase following stable engraftment of cells producing enzyme within the affected individual. (nature.com)
Engraftment syndrome following hematopoietic stem cell transplantation. (springer.com)
Non-myeloablative conditioning regimens achieve engraftment without eradication of host hematopoietic cells, which potentially allows for protection against infections commonly seen in hematopoietic cell transplantation patients treated with standard intensity conditioning regimens. (haematologica.org)
9 - 11 Non-myeloablative conditioning regimens achieve engraftment with less toxicity and host hematopoietic cells are not immediately eradicated. (haematologica.org)
The goal was to promote engraftment and let the graft versus tumour effect eliminate tumour cells. (smw.ch)
Mixed T-cell chimerism at engraftment and absence of chronic graft versus host disease (cGVHD) were associated with relapse (P = 0.04 and P = 0.02, respectively). (luriechildrens.org)
Mixed T-cell chimerism at engraftment was predictive in patients without cGVHD (P = 0.03). (luriechildrens.org)
Patients with engraftment mixed T-cell chimerism may warrant closer disease monitoring and consideration for early intervention. (luriechildrens.org)

Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
The previous experience among pediatric patients have now expanded to adults, and the number of CB transplants has reached 30,000. (frontiersin.org)
Other patients who receive bone marrow transplants include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia and was born with defective stem cells. (citizendium.org)
A Retrospective Cohort Analysis to Determine the Incidence of CMV Viremia and Progression to CMV Disease in Pediatric Patients Receiving Allogeneic Hematopoietic Cell Transplantation at an Academic Children's Hospital. (upenn.edu)
Improving and Standardizing the Recognition and Documentation of Malnutrition for Inpatient Pediatric Oncology and Stem Cell Transplant. (upenn.edu)
Successful treatment of Pulmonary Mucormycosis in Two Pediatric Hematopoietic Cell Transplant Patients. (upenn.edu)
Pediatric Transplantation February 2018 Notes: (Accepted for publication, February 2018). (upenn.edu)
Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist-Oncologist, 1st Edition: Elsevier Health Sciences 2018. (upenn.edu)
In 1998, she became medical director of the Pediatric Transplant Unit at Children's Hospital and, in 2007, was appointed clinical director of the Pediatric Stem Cell Transplant Program. (dana-farber.org)
We have also worked to characterize the chronic pulmonary conditions associated with allogeneic transplant in the pediatric setting and, in conjunction with our colleagues in dental medicine, described the oral manifestations of graft-versus-host disease (GVHD). (dana-farber.org)
Risk factors for transplant-associated thrombotic microangiopathy and mortality in a pediatric cohort. (dana-farber.org)
The use of interval-compressed chemotherapy with the addition of vincristine, irinotecan, and temozolomide for pediatric patients with newly diagnosed desmoplastic small round cell tumor. (childrenshospital.org)

We identified 144 patients in the study period, of which 115 patients were eligible for the study because they received an allogeneic transplant, of these 115 cases, 41 patients were excluded due to that they did not achieve the graft for the reasons that are specified in the results section, leaving 74 patients for the final analysis. (scirp.org)
Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft. (semanticscholar.org)
In the allogeneic setting, graft-versus-host disease may also develop, making post-transplant management complex. (cmaj.ca)
Graft source (cord blood, bone marrow or peripheral blood stem cells) which may impact on speed to marrow recovery. (renalandurologynews.com)
Autologous transplants have the advantage of a lower risk of graft rejection, infection and graft-versus-host disease. (citizendium.org)
This case series describes 7 patients with severe chronic graft-versus-host disease (cGvHD) associated with bronchiolitis obliterans (BO) after allogeneic hematopoietic stem cell transplantation (HCT) who underwent lung transplantation. (transplantnow.com)
At 100 days post-transplant, the cumulative incidence of grade III to IV acute graft-vs-host disease (GVHD) occurred in 3% of patients receiving abatacept compared to 32% receiving calcineurin inhibitor and methotrexate (CNI/MTX) and 22% receiving CNI/MTX plus antithymocyte globulin (+ATG). (ascopost.com)
Results from a phase II clinical trial presented by Kean et al at the 59th American Society of Hematology (ASH) Annual Meeting ( Abstract 212 ) show that the drug abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GVHD) in patients receiving hematopoietic stem cell transplants. (ascopost.com)
Given the serious threat of graft-vs-host disease, new approaches to make stem cell transplants safer for patients remain a critical unmet need," said Leslie Kean, MD, PhD , the trial's principal investigator and Associate Director of the Ben Towne Center for Childhood Cancer Research at Seattle Children's. (ascopost.com)
Preventing graft-vs-host disease and relapse after transplant requires a difficult balance of eliminating the bad, overactive effector T-cells, without suppressing the good, regulatory T-cells," said Dr. Kean, who is also Associate Professor of Pediatrics at the University of Washington School of Medicine and a member of the Fred Hutchinson Cancer Research Center . (ascopost.com)
Historically, unmanipulated T-cell-replete haploSCT grafts with conventional graft-versus-host-disease (GVHD) prophylaxis used in the late 1970s were associated with intense bidirectional alloreactivity and unacceptably high morbidity and mortality rates due to hyperacute GVHD and graft rejection ( 4 , 5 , 6 ). (mhmedical.com)
Graft-versus-host disease occurs when the donated T cells, white blood cells in the immune system that fight infection, launch a vigorous attack on a patient's organs, including the skin, liver, kidneys, lung, and the gastrointestinal tract. (seattlechildrens.org)
As a transplant physician, it's beyond heartbreaking to witness a patient develop severe acute graft-versus-host disease after having their leukemia cured through bone marrow transplant," said Kean. (seattlechildrens.org)
Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease. (springer.com)
However, graft-versus-host disease and its therapies continue to be significant risk factors for invasive cytomegalovirus and fungal infection in patients undergoing non-myeloablative transplantation, particularly in the late period after conditioning. (haematologica.org)
Continuing increased risk of oral/esophageal cancer after allogeneic hematopoietic stem cell transplantation in adults in association with chronic graft-versus-host disease. (springer.com)
2013). Patient survival in each treatment setting is dependent on many other factors besides the efficiency of establishing a good HSC transplant graft that restores effective hematopoiesis. (regmednet.com)

These long-lasting T cell deficiencies have been shown to play a direct role in post-transplant complications. (clinicaltrials.gov)
5 transplants with only partial matching for HLA antigens are associated with a higher risk of post-transplant complications. (cmaj.ca)
Intensive care, support and interventions stand to rescue the patient from otherwise fatal complications of therapy and require a high level of collaboration among intensive care and transplant providers. (renalandurologynews.com)
Day post-transplant, which will impact on complications likely to occur, types of infections likely and expectation of timing for marrow recovery. (renalandurologynews.com)
Chapter 18: "Infectious Complications in Hematopoietic Stem Cell Transplant. (upenn.edu)
Mycobacterium tuberculosis infections are uncommon complications in the haematopoietic stem cell post-transplant period. (ecancer.org)
With respect to decreasing the acute complications of transplant, we have examined the role of defibrotide, an agent that is effective in treating patients with severe veno-occlusive disease of the liver, and explored how to best address the nutritional needs of our patients. (dana-farber.org)
She tolerated the transplant without complications and was in remission until January 2012 when routine blood work identified increased serum protein and anemia. (hindawi.com)
Therapeutic Impact and Complications Associated with Surgical Lung Biopsy after Allogeneic Hematopoietic Stem Cell Transplantation in Children. (childrenshospital.org)

Hematopoietic cell transplantation (HCT) provides a life-prolonging or potentially curative treatment option for patients with hematologic malignancies. (nccn.org)
New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors. (springer.com)
These advances make transplantation a viable treatment for many more patients with hematologic malignancies. (ascopost.com)
Malignancies after hematopoietic cell transplantation for primary immune deficiencies: a report from the Center for International Blood and Marrow Transplant Research. (semanticscholar.org)

CD133 allows elaborated discrimination and quantification of haematopoietic progenitor subsets in human haematopoietic stem cell transplants. (semanticscholar.org)
Tunneling nanotubes mediate the transfer of stem cell marker CD133 between hematopoietic progenitor cells. (semanticscholar.org)
Age-Related Increase of EED Expression in Early Hematopoietic Progenitor Cells is Associated with Global Increase of the Histone Modification H3K27me3. (semanticscholar.org)
CB progenitor/stem cell content has been compared with adult stem cells revealing higher long-term repopulating capacity compared to bone marrow-mesenchymal stromal cells and lesser oncogenic potential than progenitor-induced stem cells. (frontiersin.org)
Newswise - Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease. (newswise.com)
Human hematopoietic stem and progenitor cells (HSPCs), derived from bone marrow, have become a primary vehicle for efforts to replace or regenerate cells destroyed by a variety of diseases. (newswise.com)
Natural gas in spanish More recently, the survey has included additional information on novel cell therapies with hematopoietic stem cells for non-hematopoietic use, as well as on the use of non-hematopoietic stem and progenitor cells. (gaselectricity.in)
Transplanted cord blood (CB) hematopoietic stem cells (HSC) and progenitor cells (HPC) can treat malignant and nonmalignant disorders. (pnas.org)

Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. (globenewswire.com)

The more common way is to collect them from the blood stream, or "peripheral blood stem cell harvesting. (thedailystar.net)
A subclinical EBV reactivation was observed in 24 cases (19.5%) with EBV-genome copies in 10(5) peripheral blood mononuclear cells ranging between 2,500 and mostly 10,000. (uzh.ch)
or =80,000 copies/10(5) peripheral blood mononuclear cells and plasma positivity prompted us to start pre-emptive therapy with rituximab and cidofovir for prevention of lymphoproliferative disease. (uzh.ch)
or =1,000 copies/10(5) peripheral blood mononuclear cells did not develop EBV-associated lymphoproliferative disease. (uzh.ch)
Peripheral expansion of T cells in a lymphopenic setting leads to a narrowing of the TCR repertoire and manifests as a decrease in the magnitude of response to new antigens. (clinicaltrials.gov)
The success of haematopoietic stem cell (HSC) transplantation largely depends on numbers of transplanted HSCs, which reside in the CD34(+) populations of bone marrow (BM), peripheral blood stem cells (PBSC) and umbilical cord blood (UCB). (semanticscholar.org)
Although stem cells can be collected by direct aspiration from the bone marrow, with the patient under general or spinal anesthetic ( Fig. 1 ), they are now more commonly harvested from the peripheral blood. (cmaj.ca)
Since the early 1990s and the availability of the stem cell growth factors GM-CSF and G-CSF , most hematopoeitic stem cell transplantation procedures have been performed with stem cells collected from the peripheral blood. (citizendium.org)
Hematopoietic stem cell transplantation (bone marrow, cord blood, or peripheral blood stem cells) may cure aplastic anemia and prevent myelodysplastic syndrome or leukemia. (medscape.com)
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. (springer.com)
The researchers collected peripheral blood mononuclear cells by leukapheresis from both patients and rectal tissue from one patient to quantify HIV DNA and perform viral co-culture from CD4+ T lymphocytes. (healio.com)
No HIV DNA was detected in any of the peripheral blood mononuclear cells from either patient, suggesting that the peripheral viral reservoir size decreased by 3 log 10 to 4 log 10 . (healio.com)
Epstein-Barr virus (EBV) load in cerebrospinal fluid and peripheral blood of patients with EBV-associated central nervous system diseases after allogeneic hematopoietic stem cell transplantation. (semanticscholar.org)
Leen and colleagues derived T cells specific to five viruses -- cytomegalovirus, adenovirus, Epstein-Barr virus, BK virus, and human herpesvirus 6 -- by stimulating peripheral blood mononuclear cells with overlapping peptide libraries of viral antigens. (medpagetoday.com)
After reduced intensity conditioning with fludarabine (40 mg/m 2 4 days), melphalan (70 mg/m 2 1 day), and thymoglobulin (2.5 mg/kg 3 days), he received a T-cell-replete peripheral blood allograft containing 5.7 × 10 6 CD34 cells/kg. (ecancer.org)

Another approach is maintenance after transplant, which has been shown to prolong not only remission but also survival in the multiple myeloma setting. (ascopost.com)

Autologous transplants have the advantage of lower risk of infection during the immune-compromised portion of the treatment, since the recovery of immune function is rapid. (wikipedia.org)
Immunosuppressive medications that compromise cell-mediated immunity can predispose to infection ( 1 , 2 ). (cdc.gov)
The authors concluded that the use of atovaquone may be associated with an increased risk of Nocardia infection after allogeneic hematopoietic stem cell transplantation, as compared with cotrimoxazole. (bioportfolio.com)
A retrospective cohort study based on data collected from the Department of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatría (INP) from January 1998 to December 2016 was performed to identify if prior infection was a predictive risk factor for aGVHD. (scirp.org)
The CPE was defined as white blood cell counts less than 3.0×109/L for four weeks or longer without infection of cytomegalovirus, human parvovirus B19 virus and Epstein-Barr virus. (sciencepg.com)
Patients receiving abatacept had intact immune reconstitution, significant improvement in transplantation-related mortality, no major uncontrolled infection and no increase in disease relapse. (seattlechildrens.org)
Induction of alloreactive cytotoxic T cells by acute virus infection of mice. (springer.com)
There have also been numerous reports of outbreaks in bone marrow transplant units and oncology wards, where infection control measures have been invaluable in controlling the spread of disease. (haematologica.org)
Conclusions Respiratory virus lower tract infection during the first 100 days after hematopoietic cell transplantation was less common in persons receiving non-myeloablative conditioning regimens compared to myeloablative conditioning, despite a similar overall rate of acquisition. (haematologica.org)
1 - 5 Though the incidence of these infections in hematopoietic cell transplantation patients usually parallels that in the community, their course can be more severe with progression to lower respiratory tract infection, co-infection with serious pulmonary co-pathogens such as invasive molds, and late airflow decline. (haematologica.org)
1000 ng/ml in the pre-transplant period (risk ratio (RR) 2.48, 95% CI 1.00?6.13), neutropenic period (0?30 days, RR 3.28, 95% CI 1.53?7.06) and intermediate period (30?100 days, RR 2.37, 95% CI 1.15?4.90) were associated with increased risk of virus infection. (unican.es)
What is the optimal approach to prevent CMV infection in patients undergoing allogeneic hematopoietic cell transplantation (AHCT) in 2018? (hematology.org)
All of the patients who got the cells prophylactically -- between 38 and 43 days after transplant -- remained free of infection by all of the viruses for more than 3 months, Leen and colleagues reported. (medpagetoday.com)
Transplant patients are among those most vulnerable to CMV infection, especially in the critical few months after the transplant. (roche.com)
Between 20% and 60% of people with a solid organ transplant develop a symptomatic CMV infection 4 . (roche.com)
Doctors believe that for many cancers, the donor's white blood cells may attack any remaining cancer cells, similar to when white cells attack bacteria or viruses when fighting an infection. (medlineplus.gov)

Importantly, cyclophosphamide spares non-alloreactive T-cells, preserving immunity and leading to a low incidence of nonrelapse mortality after HLA-haploidentical transplantation. (springer.com)
Secondary solid cancers after allogeneic hematopoietic cell transplantation using busulfan-cyclophosphamide conditioning. (springer.com)
Each of the following patients had undergone myeloablative conditioning with cyclophosphamide and total-body irradiation before transplantation and was receiving oral acyclovir for herpesvirus prophylaxis at the time of presentation. (ajnr.org)

Patients with acute myeloid leukemia (AML) who relapse after hematopoietic stem cell transplantation (HCT) have dismal outcomes. (luriechildrens.org)

Furthermore, introduction of reduced intensity conditioning protocols, better HLA matching, and recognition of the importance of HLA-C have improved CB transplants success by decreasing transplant-related mortality. (frontiersin.org)
The effect of pre-transplant factors such as age, disease stage, transfusions, iron parameters and comorbidity on overall survival (OS), non-relapse mortality (NRM), and relapse incidence (RI) was evaluated in 201 patients. (ru.nl)
Pre-transplant anemia is an independent risk factor for increased mortality following alloHSCT. (ashpublications.org)
Background Respiratory virus infections are important causes of morbidity and mortality after hematopoietic cell transplantation. (haematologica.org)
Community-acquired respiratory infections (parainfluenza 1-4, influenza A and B, respiratory syncitial virus, and rhinovirus) are important causes of morbidity and mortality after hematopoietic cell transplantation. (haematologica.org)
Thus, pre-transplant MBL levels would be important in predicting susceptibility to viral infections and mortality and might be considered a biomarker to be included in the pre-transplantation risk assessment. (unican.es)
Reduced mortality after allogeneic hematopoietic-cell transplantation. (springer.com)
Second cancer risk and late mortality in adult Australians receiving allogeneic hematopoietic stem cell transplantation: a population-based cohort study. (springer.com)
Late mortality and causes of death among long-term survivors after allogeneic stem cell transplantation. (springer.com)

The cell-based markets was analyzed for 2017, and projected to 2027.The markets are analyzed according to therapeutic categories, technologies and geographical areas. (globenewswire.com)

Once a transplant recipient is discharged from hospital and returns to his or her local community, the primary care physician can play an important role in care. (cmaj.ca)
The ethnicity/race of the recipient can also limit MUD transplantation as approximately 30% of Caucasians, 70% of Hispanics, and 90% of African Americans do not have a MUD in the worldwide registries ( 3 ). (mhmedical.com)
Can the negative effect of being a CMV-seropositive transplant recipient be overcome? (hematology.org)
The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. (medlineplus.gov)

This is a retrospective cohort study based on data collected from the allogenic transplant performed at the Department of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatría (INP) registered in a database, from January 1998 to December 2016. (scirp.org)
At the end of 2015, James Sherley, director of stem cell medicine biotechnology company Asymmetrex, listed 9 areas of stem cell medicine that could improve in 2016, if new methods for counting tissue stem cells were employed. (regmednet.com)

Alternative sources of haematopoietic stem cells, such as HLA mismatched (haplo-identical) family members and cord blood, may be available. (nice.org.uk)
Another type of HSC source is cord blood cells that are used in umbilical cord blood transplants. (thedailystar.net)
As cord blood (CB) enables rapid access and tolerance to HLA mismatches, a number of unrelated CB transplants have reached 30,000. (frontiersin.org)
Such transplant activity has been the result of international accreditation programs maintaining highly qualified cord blood units (CBUs) reaching more than 600,000 CBUs stored worldwide. (frontiersin.org)
Among many sources of hematopoietic stem cell sources, cord blood (CB) is the one that belongs to the earliest stages of life. (frontiersin.org)
Allogeneic transplants are also performed using umbilical cord blood as the source of stem cells. (citizendium.org)
Furthermore, cryopreserved cord blood has become an accepted stem cell source [5-for certain indications. (smw.ch)
As well as using stem cells from a donor's blood, cells from umbilical cord blood can also be used. (medicalnewstoday.com)
Umbilical cord blood stem cells are frozen at birth, which is important because they do not suffer any environmental damage or aging. (medicalnewstoday.com)
As a result, cord blood transplants do not require such a high level of tissue matching. (medicalnewstoday.com)
HSCs are adult tissue stem cells found naturally primarily in the bone marrow and in umbilical cord blood. (regmednet.com)
Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. (globenewswire.com)
Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
Umbilical cord blood cells are very immature so there is less of a need for perfect matching. (medlineplus.gov)

A myeloablative conditioning regimen was applied for most patients except for haploidentical transplants that received a reduced intensity conditioning regimen. (scirp.org)

Prophylaxis and treatment of Pneumocystis Jirovecii pneumonia after solid organ transplantation. (bioportfolio.com)
Depletion of naive T cells using clinical grade magnetic CD45RA beads: a new approach for GVHD prophylaxis. (springer.com)
To test them, the researchers infused between five and 20 million cells into 11 patients, eight of them to treat existing infections -- some multiple -- and three as prophylaxis. (medpagetoday.com)

The rationale underlying autologous transplantation is to deliver high doses of chemotherapy (with or without radiotherapy). (thedailystar.net)
Whereas anti-tumour effects rely solely on high-doses of chemotherapy in autologous transplants, allogeneic HSC may also have beneficial immune activity that kills tumour/leukaemia. (thedailystar.net)
In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. (wikipedia.org)
More recently non-myeloablative, " "mini transplant (microtransplantation) ," procedures have been developed that require smaller doses of preparative chemotherapy and radiation. (wikipedia.org)
The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
Children or adults with aplastic anemia have lost their stem cells after birth and may not require such high doses of chemotherapy and irradiation prior to a transplant. (citizendium.org)
More recently non-myeloablative, or so-called "mini transplant," procedures have been developed which do not require such large doses of chemotherapy and radiation. (citizendium.org)
PT-Hb levels were determined within 2 weeks prior to transplantation, after commencing conditioning chemotherapy. (ashpublications.org)
The cells are cleaned and frozen before being reintroduced to the individual after they receive the chemotherapy drugs. (medicalnewstoday.com)
Ablative (myeloablative) treatment -- High-dose chemotherapy, radiation, or both are given to kill any cancer cells. (medlineplus.gov)
Reduced intensity treatment, also called a mini transplant -- Lower doses of chemotherapy and radiation are given before a transplant. (medlineplus.gov)
Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
A bone marrow transplant replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation. (medlineplus.gov)

Pre-transplant organ function, including renal, pulmonary and cardiac evaluations, as well as changes in those organ functions since admission. (renalandurologynews.com)
Yellow fever vaccination in organ transplanted patients: is it safe? (transplantnow.com)
The two most common types of transplants are solid organ transplants and hematopoietic stem cell transplants 5 . (roche.com)
People receive solid organ transplants to replace organs that have failed due to disease or injury. (roche.com)
A solid organ patient's transplant journey is complex. (roche.com)
Generally, organ transplant patients are tested for CMV at least twice before the transplant. (roche.com)
The type of transplant also affects the CMV risk - lung, heart and multi-organ transplants carry the highest risk, kidney and stem cell transplants the lowest. (roche.com)
1 , 2 , 3 , 4 , 5 These findings suggest the potential of bone marrow derived stem cells to transdifferentiate into a variety of organ tissues, including those of the eye. (pubmedcentralcanada.ca)

MR imaging is typically obtained during the work-up of patients who have undergone allogeneic hematopoietic stem-cell transplant who present with unexplained change in mental status, amnesia, or seizures. (ajnr.org)

Broad-spectrum T cells appear to effectively treat the viral infections that commonly follow an hematopoietic stem cell transplant, researchers reported. (medpagetoday.com)
In a small clinical trial, infusions of T cells were associated with a 94% response rate when used to treat patients with up to four viral infections, according to Ann Leen, PhD , of the Baylor College of Medicine in Houston, and colleagues. (medpagetoday.com)
The researchers cautioned that the study was small -- just 11 patients -- and cannot demonstrate definitively that the transplanted cells were responsible for curing the viral infections. (medpagetoday.com)
Opportunistic viral infections are common in the wake of an hematopoietic stem cell transplant for such diseases as acute lymphoblastic leukemia and non-Hodgkin's lymphoma. (medpagetoday.com)
The response rate for the 18 infections (involving five different viruses) was high: 94% with 15 complete and two partial responses, the researchers reported, and in all cases, viral clearance was associated with an increase in T cells directed against the infecting pathogen. (medpagetoday.com)
With multisystemic disease, Langerhans cell histiocytosis must be distinguished from familial hemophagocytic lymphohistiocytosis (FHL) and viral-associated hemophagocytic syndrome. (medscape.com)
Post-transplant patients normally undergo polymerase chain reaction (PCR) testing for the first three months after the transplant to measure "viral load" - that is, how much CMV is in the body. (roche.com)

The treatment that immediately precedes infusion of HSC is called conditioning therapy and is given to help kill tumour cells, "wipe out the memory" of the recipient's immune system, and create "space" within the bone marrow for the incoming stem cells to grow. (thedailystar.net)
Many immunodeficiencies can now be cured by replacing the immune system with a bone marrow transplant. (ncl.ac.uk)
Furthermore, we may be able to use immune therapy in the autologous setting, perhaps with vaccination strategies or with genetically altered immune cells (ie, chimeric antigen receptors) that target residual cancer. (ascopost.com)
This therapy reduces the immune system's function to make sure it doesn't reject the organs or stem cells. (roche.com)
A disease that affects the production of bone marrow cells, such as aplastic anemia , congenital neutropenia , severe immune system illnesses, sickle cell anemia , or thalassemia . (medlineplus.gov)
Ig is also used for removal of harmful antibodies and for blocking damage from immune cells. (unicare.com)
Macrophages and dendritic cells are bone marrow derived antigen presenting cells (APC) which serve in the first step of the acquired immune responses. (pubmedcentralcanada.ca)
Management of TTC7A deficiency currently entails bowel resection for any atresias, possibly hematopoietic stem cell transplantation to correct the immunodeficiencies, and immunosuppression to help alleviate bowel disease and immune disregulation. (wikipedia.org)
Research indicates that TTC7A deficiency results in "increased Rho kinase activity which disrupts polarity, growth, and differentiation of intestinal epithelial cells, and which impairs immune cell homeostasis, thereby promoting MIA-CID development. (wikipedia.org)

Underlying disease or indication for transplant, which will help indicate unique risks for the patient as well as potential prognosis for survival. (renalandurologynews.com)
The median survival after lung transplantation in this group was 24 months. (transplantnow.com)
Significant survival advantages for the abatacept group were demonstrated at 1-year post-transplant. (ascopost.com)
As a result, patients receiving the post-transplant regimen with abatacept experienced improved disease-free and overall survival compared to those who did not. (ascopost.com)
In this cohort, characterized by low comorbidity and a short interval between diagnosis and transplantation, NRM was the most determinant factor for survival after SCT (47 % after 2-year follow-up). (ru.nl)
A retrospective analysis of 511 patients consecutively transplanted between January 1995 and March 2000 was performed to evaluate survival, cause of death, and PT-Hb. (ashpublications.org)
Significant survival advantages for the abatacept group were demonstrated at one year post-transplant. (seattlechildrens.org)
Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice. (springer.com)

He was recruited to the NCI in 2000 to transplant newly identifed primary immunodeficiency diseases.He is a member of the American Society for Clinical Investigation and the American Society of Hematology. (cancer.gov)

Dr Colin Phipps Diong, Parkway Cancer Centre's new consultant specialising in lymphoma and blood cancers, and haematopoietic stem cell transplantation, explains haematopoietic stem cell transplantation. (thedailystar.net)
Hematopoietic stem cell transplantation was first used as a treatment for some types of cancer but is now widely used as a therapy for various autoimmune diseases. (medicalnewstoday.com)
Programmed death 1 ligand (PD-L1) is an immunomodulatory molecule expressed by cancer cells, and it has been widely demonstrated to inhibit host antitumor responses. (springer.com)
Up to 4.3 years after transplant, HIV DNA was not detected in the blood and rectal tissue among two patients with HIV who underwent hematopoietic stem cell transplantation for cancer, researchers reported at the 2013 International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention in Kuala Lumpur, Malaysia. (healio.com)
Data from a randomized study in patients with non-small cell lung cancer treated with etoposide (in combination with cisplatin) support the use of etoposide for the treatment of this condition [Arriagada . (drugs.com)
Additional data from a phase III trial in patients with stage IIIA non-small cell lung cancer with ipsilateral mediastinal nodal metastases also supports the use of etoposide (in combination with cisplatin and radiation therapy) for the treatment of this condition [Albain . (drugs.com)
Based on American Society of Clinical Oncology Guidelines for Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer , etoposide (in combination with platinum therapy) may be considered for stage IV non-small cell lung cancer patients with large-cell neuroendocrine carcinoma. (drugs.com)
Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. (globenewswire.com)
Dr. Hickstein trained in hematology and hematopoietic stem cell transplantation at the University of Washington School of Medicine and the Fred Hutchinson Cancer Research center. (cancer.gov)

Lung transplantation may be performed for severe refractory BO. (transplantnow.com)
The authors conclude that lung transplantation is a possible therapeutic option for certain patients with severe therapy-refractory BO. (transplantnow.com)
Anti-B-cell monoclonal antibody treatment of severe posttransplant B-lymphoproliferative disorder: prognostic factors and long-term outcome. (semanticscholar.org)
Hematopoietic stem cell transplants are used to treat leukaemias, lymphomas and some non-cancerous disorders like severe immunodeficiencies. (roche.com)
To assess HSC capability, defrosts from single collections were bead-separated into CD34 + cells and infused into sublethally irradiated nonobese diabetic (NOD)/severe combined immunodeficient (SCID) mice. (pnas.org)

Although ADAMTS13 activity less than 5% was noted in 60% of patients with acute TTP, it was not found in any patients with hemolytic-uremic syndrome (HUS) or in any patients with transplant-associated TMA. (cancernetwork.com)
Acute GVHD is a complication that can arise after stem cell transplantation. (ascopost.com)
At 100 days post-transplant, the cumulative incidence of grade III to IV acute GVHD occurred in 3% of patients receiving abatacept compared to 32% receiving CNI/MTX and 22% receiving +ATG. (ascopost.com)
DECOPI (DEsobstruction COronaire en Post-Infarctus): a randomized multi-centre trial of occluded artery angioplasty after acute myocardial infarction. (nih.gov)

Bronchiolitis Obliterans (BO) is an obstructive lung disease that can affect individuals that have undergone a lung or hematopoietic stem cell transplant. (clinicaltrials.gov)
In the USA and other western nations, respiratory syncytial virus is one of the most commonly encountered respiratory viruses among patients who have been diagnosed with a hematologic malignancy or who have undergone a stem cell transplant. (haematologica.org)

Funding for this research came, in part, from the National Institutes of Health (R21-NS090066, RO1-DK090058) the Cystinosis Research Foundation the Sanford Stem Cell Clinical Center and the California Institute of Regenerative Medicine. (newswise.com)
Premature red cell death causes clinical symptoms of hemolytic anemia. (haematologica.org)
She is also Principal Investigator for the Data and Coordinating Center of the Blood and Marrow Transplant Clinical Trials Network. (ascopost.com)
GlaxoSmithKline plc (LSE/NYSE: GSK) today announced that new data from a Phase III clinical study supports the safety and efficacy of Shingrix (Zoster Vaccine Recombinant, Adjuvanted) in preventing shingles (herpes zoster) when given to adults 18 years and above shortly after undergoing autologous haematopoietic stem cell transplant (auHSCT). (gsk.com)
15 yr, can be efficiently retrieved, and most likely remain effective for clinical transplantation. (pnas.org)

Finally, Dr. George does not discuss an important subset of oncology patients, those undergoing hematopoietic stem cell transplant. (cancernetwork.com)

Design and Methods We performed a retrospective cohort study to measure the incidence and severity of parainfluenza types 1-4, influenza (A and B), respiratory syncitial virus and human rhinovirus disease in myeloablative versus non-myeloablative versus autologous hematopoietic cell transplantation patients. (haematologica.org)
We performed a retrospective cohort study to measure the incidence and severity of these infections in myeloablative versus non-myeloablative hematopoietic cell transplantation patients. (haematologica.org)
Solid tumors after hematopoietic stem cell transplantation in Japan: incidence, risk factors and prognosis. (springer.com)

Hematopoietic stem cell transplantation therapy is potentially curative for many malignant and non-malignant hematopoietic disorders. (clinicaltrials.gov)
The main indications for transplant were lymphoproliferative disorders (54.5 percent) and leukemias (33.8 percent), and the majority took place in either Europe (48 percent) or the Americas (36 percent). (wikipedia.org)
Skin lesions of Langerhans cell histiocytosis must be differentiated from other dermatologic disorders, such as diaper rash, seborrheic dermatitis, juvenile xanthogranulomas, xanthoma disseminatum, and various other skin eruptions. (medscape.com)
Cell therapy has applications in a large number of disorders. (globenewswire.com)

Supportive care for patients with symptomatic Fanconi anemia includes transfusions of packed RBCs that have been leukodepleted (and are not from family members, to avoid sensitization in case of a future transplantation). (medscape.com)

Stem cell transplants are approved to treat various cancers. (medicalnewstoday.com)
The aim of the present study was to identify clinicopathological features associated with PD-L1 expression in the secondary solid cancers of patients after allogeneic hematopoietic stem cell transplantation. (springer.com)
The present results revealed distinct PD-L1 expression in the secondary solid cancers of post-transplant patients with chronic GVHD. (springer.com)
Solid cancers after allogeneic hematopoietic cell transplantation. (springer.com)

In this group, 6 patients underwent bilateral lung transplantation and 1 underwent single lung transplantation. (transplantnow.com)

A lot of effort really needs to be devoted to addressing why some patients are cured and others are not after autologous transplant and allogeneic transplant-the answer might differ for those two approaches-and what can we do about it. (ascopost.com)

Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)

The reinfusion of the patient's own stem cells acts to rescue the bone marrow from toxicity. (thedailystar.net)

The term haematopoietic stem cell (HSC) refers to cells made in the blood factory or bone marrow that have the potential to grow into almost any type of blood cell. (thedailystar.net)
In this procedure, blood is drawn from one arm, which then goes through a machine that filters out stem cells and white blood cells. (thedailystar.net)
After conditioning therapy, stem cells are infused into the bloodstream (usually between 30 and 60 minutes), akin to a blood transfusion procedure. (thedailystar.net)
The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood-cell production. (wikipedia.org)
Bronchiolitis obliterans or bronchiolitis obliterans syndrome is a lung disorder that occurs as a complication of either lung transplantation or bone marrow/blood stem cell transplantation. (clinicaltrials.gov)
In bronchiolitis obliterans, the body s white blood cells or white blood cells from the transplant attack the lungs, which leads to the destruction of lung tissue, and ultimately, scarring or fibrosis of the lung tissues. (clinicaltrials.gov)
Researchers are interested in testing whether inhaled cyclosporine therapy could be used as a safe and effective treatment for bronchiolitis obliterans or bronchiolitis obliterans syndrome occurring after bone marrow/blood stem cell or lung transplants. (clinicaltrials.gov)
Individuals between 10 and 80 years of age who have been diagnosed with bronchiolitis obliterans or bronchiolitis obliterans syndrome after blood or lung transplants. (clinicaltrials.gov)
Time Frame: Participants will have blood drawn at baseline and on Days 1, 7, 10, 28, and 90 post vaccinations following hematopoietic stem cell transplantation. (clinicaltrials.gov)
Participants will have blood drawn at baseline to Day 90 post vaccinations following hematopoietic stem cell transplantation. (clinicaltrials.gov)
The blood is then collected by venipuncture and subjected to leukapheresis to obtain the cells for transplantation. (cmaj.ca)
Dr. Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells . (citizendium.org)
We retrospectively reviewed all blood cultures performed in 1453 patients who received HSC transplant at our institution between 1980 and 2002. (nih.gov)
The blood group remained B (recipient's pre-transplant blood group) on both the forward and reverse grouping. (nature.com)
This analysis by the Swiss Blood Stem Cell Transplantation Group, based on data from 2008-2011, describes, treatment rates in Switzerland for specific indications and compares this with data from Germany, France, Italy and the Netherlands, corrected for the size of the population. (smw.ch)
2 The treatment for PKD is mainly supportive, and consists of regular red blood cell transfusions, splenectomy and chelation therapy for iron overload. (haematologica.org)
In addition, medical treatments called mobilizations can induce the cells to move from the bone marrow into the blood stream. (regmednet.com)
HSCs function to initiate and sustain production of the many different mature blood cells, including red blood cells, white blood cells, and platelets, that must be continuously replenished throughout life. (regmednet.com)
The bone marrow produces blood cells. (medlineplus.gov)
Stem cells are immature cells in the bone marrow that give rise to all of your different blood cells. (medlineplus.gov)
Due to the smaller number of stem cells, blood counts take much longer to recover. (medlineplus.gov)
The stem cells travel through the blood into the bone marrow. (medlineplus.gov)
and 47,000 red blood cells (RBC)/mm 3 . (ajnr.org)

Many pre-transplant factors are known to influence the outcome of allogeneic stem cell transplantation (SCT) treatment in myelodysplastic syndromes (MDS). (ru.nl)
Negative Impact of Pre-Transplant Anemia on Long-Term Outcome after Allogeneic Hematopoietic Stem Cell Transplantation. (ashpublications.org)
The questionnaire contained questions on disease characteristics, pre-transplant condition, transplant regimen and post-transplant outcome. (haematologica.org)
The primary outcome is the fraction of patients who maintain any form of anti-retroviral therapy, including enfuvirtide monotherapy, through day 60 post-transplant. (knowcancer.com)

Anatomy37

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Cyclophosphamide3

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Mortality9

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Recipient4