Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Hematologic Neoplasms: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Immunocompromised Host: A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.Transplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Peripheral Blood Stem Cell Transplantation: Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Histocompatibility: The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.MycosesWhole-Body Irradiation: Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.Hematopoiesis: The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).Kidney Transplantation: The transference of a kidney from one human or animal to another.Aspergillosis: Infections with fungi of the genus ASPERGILLUS.Hematopoietic Stem Cell Mobilization: The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.Hematologic Diseases: Disorders of the blood and blood forming tissues.Hepatic Veno-Occlusive Disease: Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Transplantation Chimera: An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Recurrence: The return of a sign, symptom, or disease after a remission.Histocompatibility Testing: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)Cord Blood Stem Cell Transplantation: Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.Cell Transplantation: Transference of cells within an individual, between individuals of the same species, or between individuals of different species.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Cell Lineage: The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Stem Cell Niche: A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.Embryonic Stem Cells: Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.BK Virus: A species of POLYOMAVIRUS apparently infecting over 90% of children but not clearly associated with any clinical illness in childhood. The virus remains latent in the body throughout life and can be reactivated under certain circumstances.Adult Stem Cells: Cells with high proliferative and self renewal capacities derived from adults.Busulfan: An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.Mesenchymal Stem Cell Transplantation: Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).Acute Disease: Disease having a short and relatively severe course.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Heart Transplantation: The transference of a heart from one human or animal to another.Lymphoproliferative Disorders: Disorders characterized by proliferation of lymphoid tissue, general or unspecified.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Myeloablative Agonists: Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Mice, Inbred C57BLColony-Forming Units Assay: A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Fetal Blood: Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.Chimerism: The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Transplantation Immunology: A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Aspergillus: A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.Graft vs Leukemia Effect: Immunological rejection of leukemia cells following bone marrow transplantation.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Pluripotent Stem Cells: Cells that can give rise to cells of the three different GERM LAYERS.Multipotent Stem Cells: Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)Stem Cell Factor: A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.TriazolesNeoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Cell SeparationLeukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Paramyxoviridae Infections: Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.Roseolovirus Infections: Infection with ROSEOLOVIRUS, the most common in humans being EXANTHEMA SUBITUM, a benign disease of infants and young children.Survivors: Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Immunosuppression: Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.Viral Load: The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Transplantation, Isogeneic: Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.Vidarabine: A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.Siblings: Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)Transplants: Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Mice, SCID: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.Neural Stem Cells: Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.Fetal Tissue Transplantation: Transference of fetal tissue between individuals of the same species or between individuals of different species.Hematopoietic System: The blood-making organs and tissues, principally the bone marrow and lymph nodes.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.Fetal Stem Cells: Cells derived from a FETUS that retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.Induced Pluripotent Stem Cells: Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Mesonephros: One of a pair of excretory organs (mesonephroi) which grows caudally to the first pair (PRONEPHROI) during development. Mesonephroi are the permanent kidneys in adult amphibians and fish. In higher vertebrates, proneprhoi and most of mesonephroi degenerate with the appearance of metanephroi. The remaining ducts become WOLFFIAN DUCTS.Lymphocyte Depletion: Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.Islets of Langerhans Transplantation: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Mice, Inbred NOD: A strain of non-obese diabetic mice developed in Japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent diabetes mellitus in which insulitis is a major histopathologic feature, and in which genetic susceptibility is strongly MHC-linked.Cell Culture Techniques: Methods for maintaining or growing CELLS in vitro.Unrelated Donors: Providers of tissues for transplant to non-related individuals.Transplantation, Heterologous: Transplantation between animals of different species.Ganciclovir: An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Herpesvirus 4, Human: The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.Proto-Oncogene Proteins c-kit: A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.Lentivirus: A genus of the family RETROVIRIDAE consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region. Five serogroups are recognized, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species.Antilymphocyte Serum: Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.Transduction, Genetic: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.Herpesvirus 6, Human: The type species of ROSEOLOVIRUS isolated from patients with AIDS and other LYMPHOPROLIFERATIVE DISORDERS. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter NK cell activity. HHV-6; (HBLV) antibodies are elevated in patients with AIDS, Sjogren's syndrome, sarcoidosis, chronic fatigue syndrome, and certain malignancies. HHV-6 is the cause of EXANTHEMA SUBITUM and has been implicated in encephalitis.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Severe Combined Immunodeficiency: Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).Virus Activation: The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.Lymphocyte Transfusion: The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.Radiation Chimera: An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.Infection: Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Graft vs Tumor Effect: Immunological rejection of tumor tissue/cells following bone marrow transplantation.Allografts: Tissues, cells, or organs transplanted between genetically different individuals of the same species.Regeneration: The physiological renewal, repair, or replacement of tissue.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Transplantation Tolerance: An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Bone Marrow Purging: Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.Donor Selection: The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Stomatitis: INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Lymphopoiesis: Formation of LYMPHOCYTES and PLASMA CELLS from the lymphoid stem cells which develop from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW. These lymphoid stem cells differentiate into T-LYMPHOCYTES; B-LYMPHOCYTES; PLASMA CELLS; or NK-cells (KILLER CELLS, NATURAL) depending on the organ or tissues (LYMPHOID TISSUE) to which they migrate.Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Retroviridae: Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.Myeloid Progenitor Cells: Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS.Epstein-Barr Virus Infections: Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).Cystitis: Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.Leukapheresis: The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.Polyomavirus Infections: Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).Immunophenotyping: Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Genetic Therapy: Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.Neoplastic Stem Cells: Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.Pyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.Leukocyte Transfusion: The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.Blood Cells: The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Adenoviridae Infections: Virus diseases caused by the ADENOVIRIDAE.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Stromal Cells: Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.Hematopoiesis, Extramedullary: The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.Transplantation, Heterotopic: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Green Fluorescent Proteins: Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Heart-Lung Transplantation: The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.Coculture Techniques: A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.Cell- and Tissue-Based Therapy: Therapies that involve the TRANSPLANTATION of CELLS or TISSUES developed for the purpose of restoring the function of diseased or dysfunctional cells or tissues.Blood Cell Count: The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.Thrombopoietin: A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.Embryo, Mammalian: The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.Minor Histocompatibility Antigens: Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the H-Y antigen.Blood Group Incompatibility: An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).Blood DonorsLiver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)Virus Diseases: A general term for diseases produced by viruses.Antigens, Ly: A group of lymphocyte surface antigens located on mouse LYMPHOCYTES. Specific Ly antigens are useful markers for distinguishing subpopulations of lymphocytes.Cytarabine: A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)Antigens, CD45: High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Hematopoietic stem cell transplantation may be ineffective.Small bowel transplant has proven successful in at least one case. ... possibly hematopoietic stem cell transplantation to correct the immunodeficiencies, and immunosuppression to help alleviate ... CD44+ prostate cancer stem cells". Biochemical and Biophysical Research Communications. 441 (3): 586-592. doi:10.1016/j.bbrc. ... and differentiation of intestinal epithelial cells, and which impairs immune cell homeostasis, thereby promoting MIA-CID ...
Bone Marrow Donors Worldwide
"Bone Marrow Transplantation 51: 675-679". 2015 - Gratwohl A, et al. One million hematopoietic stem-cell transplants: a ... The BMDW is the world's largest hematopoietic cell database, listing more than 29.5 million stem cell donors and over 721,289 ... used to perform what used to be called bone marrow transplants, but now referred as hematopoietic cell transplants) and cord ... such as search coordinators and transplant physicians from transplant centres, stem cell donor registries, and cord blood banks ...
"Outcome of 27 patients with Hurler's syndrome transplanted from either related or unrelated haematopoietic stem cell sources". ... However, the severe immunosuppression that bone marrow transplantation requires causes a significant risk of serious infections ... A second transplant has also been performed on the child's older brother, and a third transplant is scheduled for a California ... Josephine Marcotty (2008-07-03). "Long-shot stem-cell treatment gives two brothers a future". Star Tribune. Retrieved 2008-07- ...
Collaborative practice agreement
Jo-Anne H. Young
"Cytomegalovirus enteritis among hematopoietic stem cell transplant recipients". Biol Blood Marrow Transplant. 7 (12): 674-9. ... against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation". Clin ... Her expertise is in the areas of transplantation, infectious diseases, infections of the immune compromised host, and clinical ... She is Medical Director of the Adult Transplant Infectious Disease Program at the University of Minnesota. Other ...
In 2013, Astellas Pharma has started on individuals who received a hematopoietic stem cell transplant a Phase III trial with ... Another phase 2 study of the same vaccine was done in patients awaiting kidney transplantation. The vaccine significantly ... Hematopoietic Cell Transplant (HCT) (HELIOS)". ClinicalTrials.gov. 2013-06-12. Retrieved 2015-10-26. "An Evaluation of a ... in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant". ...
Transplantable organs and tissues
Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (that is ... 1999). "Autologous haematopoietic stem cell transplants for autoimmune disease--feasibility and transplant-related mortality. ... With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoietic stem cell transplantation procedures ... "Peripheral blood stem cells for allogeneic transplantation: a review". Stem Cells. 19 (2): 108-17. doi:10.1634/stemcells.19-2- ...
Robert Peter Gale
He has worked on alternate sources of hematopoietic stem cells including fetal liver transplants. Gale has published over 1000 ... From 1993-1999, Gale was Senior Physician and Corporate Director of Bone Marrow and Blood Cell Transplantation at Salick Health ... He also developed the bone marrow transplant program supported by the NIH. At UCLA, he was active in the Department of ... in over 60 countries worldwide working together to analyze and advance knowledge about blood cell and bone marrow transplants. ...
Hematopoietic stem cell transplantation, which transplants these cells from a young donor to an older recipient, rejuvenates ... as well as in individual cell types such as CD4 T cells, CD14 monocytes, glial cells, neurons, immortalized B cells, ... it is close to zero for embryonic and induced pluripotent stem cells; second, it correlates with cell passage number; third, it ... It is an intrinsic mechanism that exists from the birth of the cell and continues. This implies that if cells are not shunted ...
City of Hope National Medical Center
On January 13, 2011, City of Hope performed its 10,000th hematopoietic stem cell transplantation, which includes transplants of ... and umbilical cord stem cells. By 2016, this has grown to over 13,000 stem cell transplants. City of Hope is a founding member ... The center has performed 13,000 hematopoietic stem cell transplants as of 2016 with patient outcomes that consistently exceed ... contract to facilitate stem cell research from laboratory to clinical study; focus on development and manufacture of stem cell ...
Stem cell controversy
... such as how many cells are sufficient for engraftment of various types of hematopoietic stem cell transplants, whether older ... This has included the many complications inherent in stem cell transplantation (almost 200 allogeneic marrow transplants were ... Not all stem cell research involves the human embryos. For example, adult stem cells, amniotic stem cells, and induced ... embryonic stem cells are likely to be easier to isolate and grow ex vivo than adult stem cells. Embryonic stem cells divide ...
... of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant. "Neues ... "FDA Approves Letermovir for CMV Prophylaxis Post-Transplantation". onclive.com. November 9, 2017. ... It has been tested in CMV infected patients with allogeneic stem cell transplants and may also be useful for other patients ... with a compromised immune system such as those with organ transplants or HIV infections. The drug was developed by Merck & Co ...
Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor ... Escape from suppression: tumor-specific effector cells outcompete regulatory T cells following stem-cell transplantation. Blood ... autologous stem cell transplant - could significantly enhance that response. To expand this immunotransplant concept to the ... vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation. Blood 2006;107( ...
Hematopoietic stem cell transplantation
Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ... Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... "Peripheral blood stem cells for allogeneic transplantation: a review". Stem Cells. 19 (2): 108-17. doi:10.1634/stemcells.19-2- ... who have lost their stem cells after birth. Other conditions treated with stem cell transplants include sickle-cell disease ...
... as well as the challenge to find HLA-matched donors for conventional hematopoietic stem cell transplantation, Dr Huisheng Ai, ... will also accelerate functional recovery of recipient's hematopoietic stem cells, greatly reducing infections and transplant- ... which will be reinitiated by donor's stem cells soon after transplantation, and will play a role as recipient-versus-tumor (RVT ... The cells employed are allogeneic peripheral blood stem cells. Matched HLA between donor and recipient is not necessary. The ...
16 December 2013 Why Perform a Stem Cell Transplant? Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation ... Stem cells are also in clinical phases for treatment in ophthalmology. Hematopoietic stem cells have been used to treat corneal ... Fetal tissue implant Human Stem Cells Institute Induced pluripotent stem cell Induced stem cells Ian Murnaghan for Explore Stem ... Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most ...
B-Cell Prolymphocytic Leukemia
A stem cell transplant is a procedure that uses highly specialized cells called hematopoietic stem cells to replace bone marrow ... However, stem cell transplantation is a high-risk procedure, with significant morbidity and mortality rates. Furthermore, it is ... for B-PLL pathologists look for prolymphocytic infiltration where the hematopoietic stem cells of the bone marrow are replaced ... "Leukemia - B-cell Prolymphocytic Leukemia and Hairy Cell Leukemia: Treatment Options , Cancer.Net". Cancer.Net. 2012-06-25. ...
1999). «Autologous haematopoietic stem cell transplants for autoimmune disease--feasibility and transplant-related mortality. ... Denne artikkelen bygger på «Hematopoietic stem cell transplantation» frå Wikipedia på engelsk, den 8. januar 2015. ... the European League Against Rheumatism and the International Stem Cell Project for Autoimmune Disease». Bone Marrow Transplant. ... 2008). «Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases». JAMA 299 (8): 925-36. ...
Lysosomal acid lipase deficiency
Some children with LAL-D have had an experimental therapy called hematopoietic stem cell transplantation (HSCT), also known as ... bone marrow transplant, to try to prevent the disease from getting worse. Data are sparse but there is a known high risk of ... and neuropsychological outcome of hematopoietic cell transplantation for Wolman disease". Bone Marrow Transplantation. 43 (1): ... both of them had been treated with hematopoietic stem cell treatment. ...
Updated: 16 December 2013 Why Perform a Stem Cell Transplant? *^ Bone Marrow Transplantation and Peripheral Blood Stem Cell ... Stem cells are also in clinical phases for treatment in ophthalmology. Hematopoietic stem cells have been used to treat corneal ... Research using both hematopoietic adult stem cells and embryonic stem cells has provided insight into the possible mechanisms ... and such research involves adult stem cells, amniotic stem cells, and induced pluripotent stem cells. ...
Autologous stem-cell transplantation
Autologous hematopoietic stem-cell transplantation Stem-cell therapy "What Are Stem Cells?". Retrieved 2017-02-12. "Autologous ... Self) Transplants". The Leukaemia Foundation. The Leukaemia Foundation. Retrieved 27 September 2017. Stamm, Christof; Westphal ... is autologous transplantation of stem cells-that is, transplantation in which stem cells (undifferentiated cells from which ... Autologous stem-cell transplantation (also called autogenous, autogeneic, or autogenic stem-cell transplantation and ...
... and haemorrhagic cystitis in haematopoietic stem cell transplant recipients. Decoy cells can be seen in a urine sample through ... The period from transplantation to the first occurrence of decoy cells in the urine and the period of decoy cell persistence in ... The latter condition mainly occurs in hematopoietic stem cell transplant recipients. Several publications have tried to use ... In renal transplant recipients, such cells may be found in up to 40 percent of cases. Decoy cells are clinically relevant since ...
Chronic myelomonocytic leukemia
Haematopoietic stem cell transplant remains the only curative treatment for CMML. However, due to the late age of onset and ... Robert J. Soiffer (17 November 2008). Hematopoietic Stem Cell Transplantation. Springer. ISBN 978-1-934115-05-3. Retrieved 23 ... as well as abnormal looking cells (dysplasia) in at least one type of blood cell. CMML shows characteristics of a ... In adults, blood cells are formed in the bone marrow, by a process that is known as haematopoiesis. In CMML, there are ...
Hematopoietic stem cell transplantation
... (Redirected from Bone marrow transplant). "Bone Marrow Transplant" redirects here. For ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... See also: List of conditions treated with hematopoietic stem cell transplantation. IndicationsEdit. Indications for stem cell ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ...
June 2008). "Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplant. 41 Suppl 2: S83-6. doi:10.1038/ ... Virus-specific T-Lymphocytes (VST) therapy is used for patients who have received hematopoietic stem cell transplantation that ... cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine ... natural killer cells and monocytes (CD15+), as well as activation markers (HLA-DR, CD25, CD80 (B cells). Tests for T cell ...
General University Hospital of Patras
... a fully accredited Allogeneic Hematopoietic Stem Cell Transplantation Program has been established, which performs all types of ... There are transplant units in several hospitals. The 4 major units that perform Allogeneic - stem cells harvested from ... In Greece, Hematopoietic Cell Transplantation (HCT) was first performed in 1985 and over 250 are now carried out every year. ... stem cells harvested from self- HCTs are found at the "EVANGELISMOS" Hospital in Athens, the "PAPANIKOLAOU" Hospital in ...
Extranodal NK/T-cell lymphoma, nasal type
December 2008). "Autologous hematopoietic stem cell transplantation in extranodal natural killer/T cell lymphoma: a ... Blood Marrow Transplant. 14 (12): 1356-64. doi:10.1016/j.bbmt.2008.09.014. PMID 19041057. Stadlmann S, Fend F, Moser P, et al ... Cutaneous T-cell lymphoma Subcutaneous T-cell lymphoma List of cutaneous conditions Jaffe, ES; Harris NL; Vardiman JW; Campo E ... Extranodal NK-T-cell lymphoma is a type of lymphoma. It is called "extranodal" to emphasize that the location is typically not ...
Hematopoietic stem cell
Hematopoiesis Hematopoietic stem cell niche Hematopoietic stem cell transplantation Birbrair, Alexander; Frenette, Paul S. ( ... cordadvantage.com/cord-blood-101/hematopoietic-stem-cell "Bone Marrow Transplant Process". Mayo Clinic. Retrieved 18 March 2015 ... Lymphoid cells include T cells, B cells, and natural killer cells.) The definition of hematopoietic stem cells has evolved ... Hematopoietic stem cells (HSCs) are the stem cells that give rise to blood cells through the process of haematopoiesis. They ...
4 Transplant donors | COVID-19 rapid guideline: haematopoietic stem cell transplantation | Guidance | NICE
The purpose of this guideline is to maximise the safety of patients who need haemopoietic stem cell transplantation and make ... 4.8 If haematopoietic stem cell transplantation (HSCT) is urgent and there are no suitable available donors, assess risk and ... COVID-19 rapid guideline: haematopoietic stem cell transplantation NICE guideline [NG164]. Published date: 01 April 2020. ... Alternative sources of haematopoietic stem cells, such as HLA mismatched (haplo-identical) family members and cord blood, may ...
Transplanting blood stem cells Haematopoietic Stem Cell Transplantation (HSCT) | The Daily Star
TRANSPLANTATION? The term haematopoietic stem cell (HSC) refers to cells made in the blood factory or bone marrow that have the ... Transplantation of HSC (HSCT) is done in order to re-establish bone marrow and immune system function after being damaged and/ ... potential to grow into almost any type of blood cell. ... blood stem cells Haematopoietic Stem Cell Transplantation (HSCT ... and haematopoietic stem cell transplantation, explains haematopoietic stem cell transplantation.. ...
Invasive diagnostic procedures for pulmonary infiltrates in pediatric hematopoietic stem cell transplant recipients - Armenian ...
A Comparison of Bronchoalveolar Lavage versus Lung Biopsy in Pediatric Recipients after Stem Cell Transplantation, Biology of ... Invasive diagnostic procedures for pulmonary infiltrates in pediatric hematopoietic stem cell transplant recipients. Authors. * ... Next article in issue: Early steroid withdrawal in pediatric renal transplant on newer immunosuppressive drugs Next article in ... Previous article in issue: Avoiding steroids in pediatric renal transplantation: Long-term experience from a single centre ...
Monitoring of Epstein-Barr virus load after hematopoietic stem cell transplantation for early intervention in post-transplant...
Monitoring of Epstein-Barr virus load after hematopoietic stem cell transplantation for early intervention in post-transplant ... Monitoring of Epstein-Barr virus load after hematopoietic stem cell transplantation for early intervention in post-transplant ... associated post-transplant lymphoproliferative disease is a life-threatening complication following hematopoietic stem cell ... associated post-transplant lymphoproliferative disease is a life-threatening complication following hematopoietic stem cell ...
Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell...
61 consecutive pediatric patients with a median age of 7.0 years who underwent hematopoietic stem cell transplantation were ... levels were regularly assessed after transplantation and during transplantation related adverse events. Veno-occlusive disease ... that proinflammatory cytokines might be putative indicators for early detection and differentiation of post-transplant adverse ... viral and fungal infections are known as adverse events after hematopoietic stem cell transplantation representing the major ...
Hematopoietic stem cell transplantation - Wikipedia
Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ... Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... "Peripheral blood stem cells for allogeneic transplantation: a review". Stem Cells. 19 (2): 108-17. doi:10.1634/stemcells.19-2- ... who have lost their stem cells after birth. Other conditions treated with stem cell transplants include sickle-cell disease ...
Rhodococcus Infection in Solid Organ and Hematopoietic Stem Cell Transplant Recipients - Volume 23, Number 3-March 2017 -...
We conducted a case-control study of 18 US transplant recipients with Rhodococcus infection and 36 matched controls. The ... Rhodococcus equi infection in transplant recipients: case report and review of the literature. Transplantation. 1998;65:449-53 ... Rhodococcus globerulus bacteremia in an allogeneic hematopoietic stem cell transplant recipient: report of the first transplant ... and outcomes of Rhodococcus infection among solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) ...
Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment...
Furthermore, inhaled cyclosporine has not been studied in the treatment of BO following hematopoietic stem cell transplantation ... Hematopoietic stem cell transplant recipients at least 99 days post transplant (group A) ... Phase II Trial of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients ... Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment ...
Akari Therapeutics Announces Pivotal Phase III Trial Design of Nomacopan in Pediatric Hematopoietic Stem Cell Transplant...
New approaches in the diagnosis, pathophysiology, and treatment of pediatric hematopoietic stem cell transplantation associated ... Akari Therapeutics Announces Pivotal Phase III Trial Design of Nomacopan in Pediatric Hematopoietic Stem Cell Transplant- ... Predicting the severity of intestinal graft-versus-host disease from leukotriene B4 levels after bone marrow transplantation. ...
Studies of the Immune Response to Vaccination After Hematopoietic Stem Cell Transplantation - Full Text View - ClinicalTrials...
These long-lasting T cell deficiencies have been shown to play a direct role in post-transplant complications. There are many ... Hematopoietic stem cell transplantation therapy is potentially curative for many malignant and non-malignant hematopoietic ... Studies of the Immune Response to Vaccination After Hematopoietic Stem Cell Transplantation. This study has been completed. ... Participants will have blood drawn at baseline to Day 90 post vaccinations following hematopoietic stem cell transplantation. ...
Caregiver Burden and Distress in Hematopoeitic Stem Cell Transplant - Full Text View - ClinicalTrials.gov
The Impact of Hematopoeitic Stem Cell Transplantation on Primary Caregiver Level of Burden and Distress. ... Caregiver Burden and Distress in Hematopoeitic Stem Cell Transplant. The safety and scientific validity of this study is the ... of this study is to examine the impact that serving as a caregiver for a patient undergoing hematopoietic stem cell transplant ... Overall Patient Survival [ Time Frame: Pre-transplant to 1 year post-transplant ]. Number of patients who are alive at 1 year ...
Can We Kill Two Birds with This Stone? Anti-Pneumocystis Prophylaxis to Prevent Nocardia Infection in Hematopoietic Stem Cell...
Infection in Hematopoietic Stem Cell Transplant Recipients.". We read with interest the recent paper by Molina and coworkers, ... may be associated with an increased risk of Nocardia infection after allogeneic hematopoietic stem cell transplantation, as ... Stem Cells Track and monitor developments in stem cell research and commercial development. Follow the tabs above to read the ... Anti-Pneumocystis Prophylaxis to Prevent Nocardia Infection in Hematopoietic Stem Cell Transplant Recipients.. 08:00 EDT 4th ...
Omeros Reports Positive Data Across Primary and Secondary Endpoints in Pivotal Trial of Hematopoietic Stem Cell Transplant...
... and other factors associated with stem cell transplantation. Endothelial damage, which activates the lectin pathway of ... all common in stem-cell transplant patients. * 21 percent of patients died during the trial due to causes common in stem cell ... Hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA) is a significant and often lethal ... Omeros Reports Positive Data Across Primary and Secondary Endpoints in Pivotal Trial of Hematopoietic Stem Cell Transplant- ...
History of Infection Prior to Hematopoietic Stem Cell Transplant in the Recipient as a Risk Factor to Develop Acute Graft...
Methods: A retrospective cohort study based on data collected from the Department of Hematopoietic Stem Cell Transplantation at ... is the most frequent and severe complication after allogeneic hematopoietic stem cell transplantation (HSCT). Objective: To ... 1Hematopoietic Stem Cell Transplant and Cell Therapy Program, National Institute of Pediatrics (INP), Mexico City, México.. 2 ... Methods: A retrospective cohort study based on data collected from the Department of Hematopoietic Stem Cell Transplantation at ...
CD133 allows elaborated discrimination and quantification of haematopoietic progenitor subsets in human haematopoietic stem...
... better marker combinations for the quantification of more primitive haematopoietic stem and progenitor cells in transplants are ... transplantation largely depends on numbers of transplanted HSCs, which reside in the CD34(+) populations of bone marrow (BM), ... peripheral blood stem cells (PBSC) and umbilical cord blood (UCB). More specifically HSCs reside in the CD38(low/-) ... cell contents. In conclusion, implementation of anti-CD133 staining into existing routine panels will improve the quality ...
Fluoride Action Network | Correlation of pain and fluoride concentration in allogeneic hematopoietic stem cell transplant...
Voriconazole-induced periostitis after allogeneic stem cell transplantation. A 64 year old man with a history of resected renal ... Correlation of pain and fluoride concentration in allogeneic hematopoietic stem cell transplant recipients on voriconazole. ... Azole therapy is widely utilized in hematopoietic stem cell transplant (HCT) recipients for the treatment of aspergillus. ... Supportive care guidelines recommend anti-mold prophylaxis in hematopoietic stem cell transplant (HSCT) recipients deemed high- ...
Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant...
Infection is the leading cause of morbidity and mortality in immunocompromised patients such as hematopoietic/solid organ ... transplant recipients and individuals with human immunodeficiency virus. Community respiratory virus infections are ... Organ Transplantation / adverse effects* * Respiratory Tract Infections / drug therapy * Respiratory Tract Infections / ... Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant ...
Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients With Cancer and Hematopoietic Stem Cell...
Frontiers | Is There Any Reason to Prefer Cord Blood Instead of Adult Donors for Hematopoietic Stem Cell Transplants? | Medicine
... the advantage and disadvantages of CB compared to adult stem cells within the context of stem cell biology and transplantation. ... the advantage and disadvantages of CB compared to adult stem cells within the context of stem cell biology and transplantation. ... Cord blood progenitor/stem cell content has been compared with adult stem cells revealing higher long-term repopulating ... Cord blood progenitor/stem cell content has been compared with adult stem cells revealing higher long-term repopulating ...
Hematopoietic stem cell transplantation - Wikipedia
Hematopoietic stem cell transplantation. (Redirected from Bone marrow transplant). "Bone Marrow Transplant" redirects here. For ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... See also: List of conditions treated with hematopoietic stem cell transplantation. IndicationsEdit. Indications for stem cell ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ...
Hematopoietic stem cell transplantation: a primer for the primary care physician | CMAJ
Recipients of stem cell transplants may be severely immunocompromised for many months after transplantation, especially if they ... Blood stem cell transplantation is accomplished by treating the donor with hematopoietic growth factors, which cause the stem ... Hematopoietic stem cell transplantation: a primer for the primary care physician Message Subject (Your Name) has sent you a ... stem cell transplantation is performed only at specialized centres. Although stem cells can be collected by direct aspiration ...
Hematopoietic stem cell transplant-complications (bone marrow transplant complications; cord blood transplant complications;...
"Gastrointestinal and hepatic complications". Thomas Hematopoietic Cell Transplantation. 2004. Copyright © 2017, 2013 Decision ... Hematopoietic stem cell transplant-complications (bone marrow transplant complications; cord blood transplant complications; ... Close more info about Hematopoietic stem cell transplant-complications (bone marrow transplant complications; cord blood ... Close more info about Hematopoietic stem cell transplant-complications (bone marrow transplant complications; cord blood ...
Hematopoietic stem cell transplant - encyclopedia article - Citizendium
... most hematopoeitic stem cell transplantation procedures have been performed with stem cells collected from the peripheral blood ... Hematopoietic stem cell transplantation (HSCT) or Bone marrow transplantation is a medical procedure in the field of hematology ... Stem cell collection. Types of donors. There are two major types of stem cell transplantation maneuvers. Autologous HSCT ... Hematopoeitic stem cell transplantation remains a risky procedure and has always been reserved for patients with life ...
Consider Thrombotic Microangiopathy in Pediatric and Hematopoietic Stem Cell Transplant Patients | Cancer Network
Transplant-associated microangiopathy in patients receiving tacrolimus following allogeneic stem cell transplantation: risk ... Transplant-Associated TMA and Hematopoietic Stem Cell Transplant Patients. Finally, Dr. George does not discuss an important ... those undergoing hematopoietic stem cell transplant. The incidence of this disorder in transplant recipients is variable, with ... Thrombotic microangiopathy in hematopoietic stem cell transplantation: diagnosis and treatment. Drugs. 2009;69:183-98. ...
Limited sampling strategies for estimation of cyclosporine exposure in pediatric hematopoietic stem cell transplant recipients ...
... in hematopoietic stem cell transplantation (HSCT). However, the use of AUC in clinical settings is restricted for practical ... Limited sampling strategies for estimation of cyclosporine exposure in pediatric hematopoietic stem cell transplant recipients ... Limited sampling strategies for estimation of cyclosporine exposure in pediatric hematopoietic stem cell transplant recipients ... dans la transplantation des cellules souches hématopoïétiques est soutenue par un nombre croissant détudes. Cependant, pour ...
Yellow Fever Vaccine Booster Doses: Recommendations of the Advisory Committee on Immunization Practices, 2015
Hematopoietic stem cell transplant recipients. Data are limited on safety and immunogenicity for yellow fever vaccine in ... However, data suggest most recipients become seronegative to live viral vaccine antigens after transplantation (14). Infectious ... Persons who received a hematopoietic stem cell transplant after receiving a dose of yellow fever vaccine and who are ... hematopoietic stem cell transplant recipients, and HIV-infected persons) who might not have as robust or sustained immune ...
Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: a single-center...
... infectious disease infectious diseases kidney transplant liver transplant living donation lung transplant lung transplantation ... Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: a single-center ... after allogeneic hematopoietic stem cell transplantation (HCT) who underwent lung transplantation. About 20% of patients with ... Transplant Now is a free service to help you stay up to date with new developments in Transplantation.. read more... ...
ASH 2017: Abatacept Nearly Eliminates Severe Acute GVHD After Hematopoietic Stem Cell Transplant - The ASCO Post
Acute GVHD is a complication that can arise after stem cell transplantation. GVHD occurs when the donated T cells launch a ... ASH 2017: Abatacept Nearly Eliminates Severe Acute GVHD After Hematopoietic Stem Cell Transplant. By The ASCO Post. Posted: 12/ ... in patients receiving hematopoietic stem cell transplants.. When added to the standard drug regimen used to prevent GVHD, ... "Given the serious threat of graft-vs-host disease, new approaches to make stem cell transplants safer for patients remain a ...
Fanconi Anemia Treatment & Management: Approach Considerations, Supportive Care, Hematopoietic Stem Cell Transplantation and...
Chromosomal Aberrations and Survival after Unrelated Donor Hematopoietic Stem Cell Transplant in Patients with Fanconi Anemia. ... Hematopoietic Stem Cell Transplantation and Androgen Therapy. Hematopoietic stem cell transplantation (bone marrow, cord blood ... HLA-matched sibling hematopoietic stem cell transplantation for fanconi anemia: comparison of irradiation and nonirradiation ... the 1-year overall survival rate following unrelated-donor hematopoietic stem cell transplantation is poor in those with clonal ...
HSCTRecipientsDonorBiol Blood Marrow TransplantMarrow TransplantationDonorsSickle-cell diPost-transplant cyclophosphamideEngraftmentPediatricGraftComplicationsMalignanciesProgenitorBone marrow transplantsPeripheralMultiple myelomaInfectionCyclophosphamideOutcomesMortality2017Recipient2016Cord bloodHaploidenticalProphylaxisChemotherapyOrganPatients who have undergoneViralImmuneSurvival2000CancerSevereAcuteUndergoneClinicalOncologyIncidenceDisordersSupportive CareCancersUnderwentAutologous transplantAllogeneic boneToxicityBloodOutcome
- 4.8 If haematopoietic stem cell transplantation (HSCT) is urgent and there are no suitable available donors, assess risk and liaise with the registry. (nice.org.uk)
- Transplantation of HSC (HSCT) is done in order to re-establish bone marrow and immune system function after being damaged and/or attacked by blood cancer. (thedailystar.net)
- The most common indications for HSCT are blood cancers, mainly acute leukaemia, cancers of the lymphatic tissues (lymphomas) and the antibody-forming blood cells (multiple myeloma). (thedailystar.net)
- HSCT can be broadly divided into autologous transplantation, where patients use their own blood stem cells, and allogeneic transplantation, where stem cells are obtained from a different person. (thedailystar.net)
- Hematopoietic stem-cell transplantation ( HSCT ) is the transplantation of multipotent hematopoietic stem cells , usually derived from bone marrow , peripheral blood , or umbilical cord blood . (wikipedia.org)
- The spectrum of target antigens associated with tumor immunity and alloimmunity after allogeneic HSCT: Host-derived T and B cells can be induced to recognize tumor-associated antigens, whereas donor-derived B and T cells can recognize both tumor-associated antigens and alloantigens. (wikipedia.org)
- Autologous HSCT requires the extraction ( apheresis ) of hematopoietic stem cells (HSCs) from the patient and storage of the harvested cells in a freezer. (wikipedia.org)
- In this study, we sought to describe characteristics, risk factors, and outcomes of Rhodococcus infection among solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients in the United States. (cdc.gov)
- Median time from transplant to infection was 5 (range 2-54) for HSCT recipients and 28 (range 3-237) months for SOT recipients. (cdc.gov)
- The purpose of this research study is to perform a serial analysis of immune function using blood cells and sera obtained from patients after vaccination following hematopoietic stem cell transplantation (HSCT). (clinicaltrials.gov)
- While innate immunity (myeloid and NK cell) is restored relatively quickly following HSCT, a prolonged period of lymphopenia occurs in all patients. (clinicaltrials.gov)
- In children who have received chemotherapy and HSCT, T cell function generally recovers within 6 to twelve months. (clinicaltrials.gov)
- There are many studies that correlate decreased T cell number and function (specifically CD4+ T cells) with an increase in post-transplant infections and relapse has been shown to be inversely proportional to T cell reconstitution following both autologous and allogeneic HSCT. (clinicaltrials.gov)
- Omeros Corporation (Nasdaq: OMER) today announced positive data from its pivotal clinical trial of the company's novel investigational complement inhibitor narsoplimab in the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA), a frequently lethal complication of HSCT. (bioportfolio.com)
- Acute graft-versus-host disease (aGVHD) is the most frequent and severe complication after allogeneic hematopoietic stem cell transplantation (HSCT). (scirp.org)
- Supportive care guidelines recommend anti-mold prophylaxis in hematopoietic stem cell transplant (HSCT) recipients deemed high-risk for invasive fungal infection, leading to long-term use of voriconazole following allogeneic HSCT in patients that remain immunocompromised. (fluoridealert.org)
- Voriconazole has been associated with periostitis, exostoses, and fluoride excess in patients following solid organ transplant, HSCT and leukemia therapy. (fluoridealert.org)
- On the other hand, reduced intensity regimens have allowed for HSCT in patients not previously eligible for transplant due to poor overall functional status, uncontrolled infection or poor organ function. (renalandurologynews.com)
- Hematopoietic stem cell transplantation (HSCT) or Bone marrow transplantation is a medical procedure in the field of hematology and oncology that involves transplantation of hematopoietic stem cells (HSC). (citizendium.org)
- Autologous HSCT involves isolation of HSC from a patient, storage of the stem cells in a freezer, high-dose chemotherapy to eradicate the malignant cell population at the cost of also eliminating the patient's bone marrow stem cells, then return of the patient's own stored stem cells to their body. (citizendium.org)
- The objective is to find out the causes of Cytopenia post-engraftment (CPE) in hematopoietic stem cell transplantation (HSCT) for patients with β-thalassemia major (β-TM). (sciencepg.com)
- Allogeneic hematopoietic stem cell transplantation (HSCT) is the preferred curative therapy for children with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). (bvsalud.org)
- Of the 12 patients who received HSCT, one died of a transplant-related cause, one died of relapse after HSCT, and 10 remain in continuous CR. (bvsalud.org)
- Hematopoietic stem cell transplantation (HSCT) is an established procedure for many acquired and congenital disorders of the hematopoietic system, including disorders of the immune system, and as enzyme replacement in metabolic disorders. (gaselectricity.in)
- Origin electricity faults 1, 2, 3, 4 The annual activity survey of the European Society of Blood and Marrow Transplantation (EBMT), describing the status of HSCT in Europe and affiliated countries, has become an instrument used to observe trends and to monitor changes in technology use. (gaselectricity.in)
- Gas and supply okc 13 The analysis of the survey data spanning over 20 years has shown a continued and constant increase in the annual numbers of HSCT and transplant rates (number of HSCT per 10 million inhabitants) for both allogeneic and autologous HSCT. (gaselectricity.in)
- Electricity prices going up In addition to transplant rates and indications, this report focuses on the use of donors other than HLA identical siblings and matched unrelated donors for allogeneic HSCT. (gaselectricity.in)
- Electricity joules Their data (2716 HSCT) from 30 actively transplanting teams makes up 6.7 % of the total data set and are included in all analyses. (gaselectricity.in)
- Gas mask bong nfl Unrelated donor transplants include HSCT from unrelated donors with peripheral blood and marrow as a stem cell source but not cord blood HSCT, these are shown as cord blood HSCT in Figure 3a. (gaselectricity.in)
- Multiple transplants may include multiple transplants defined as subsequent transplants within a planned double or triple autologous or allogeneic transplant protocol, and retransplants (autologous or allogeneic) defined as unplanned HSCT for rejection or relapse after a previous HSCT. (gaselectricity.in)
- Transplant rates, defined as the total number of HSCT per 10 million inhabitants, were computed for each country without adjustments for patients who crossed borders and received their HSCT in a foreign country. (gaselectricity.in)
- We sought to determine whether enzyme replacement therapy (ERT) with iduronidase in the peritransplant period affects outcome of hematopoietic stem cell transplantation (HSCT) for MPS IH. (nature.com)
- The first experience with hematopoietic stem cell transplantation (HSCT) as therapy for Hurler was reported by Hobbs, 8 and since that time HSCT has been accepted as the standard of care for patients with MPS IH, as this results in engraftment of cells within the brain, providing enzyme to the central nervous system, halting neurocognitive decline. (nature.com)
- While outcomes after HSCT have improved with the availability of improved methods for stem cell graft typing and supportive care, concerns remain regarding the toxicity of transplantation. (nature.com)
- Patients who undergo pediatric Hematopoietic Stem Cell Transplantation (HSCT) may experience long-term psychological sequelae and poor Quality of Life (QoL) in adulthood. (frontiersin.org)
- 0.05) associated with specific socio-demographic and medical variables (gender, type of pathology, type of HSCT, time elapsed between communication of the need to transplant and effective transplantation, and days of hospitalization). (frontiersin.org)
- The NCD for Stem Cell Transplantation Multiple Myeloma (MM), Myelofibrosis (MF) and Sickle Cell Disease (SCD), released by CMS on January 27, 2016, concluded that, CMS will cover items and services necessary for research under §1862(a)(1)(E) for a allogeneic hematopoietic stem cell transplant (HSCT) for certain Medicare beneficiaries with myelofibrosis (MF) using the Coverage with Evidence Development (CED) paradigm. (cms.gov)
- Allogeneic HSCT for sickle cell disease (SCD) will be covered by Medicare only for beneficiaries with severe, symptomatic sickle cell disease who participate in an approved prospective clinical study. (cms.gov)
- Pure red cell aplasia (PRCA) is a rare but well-recognized immunohematological complication that occurs in the setting of major ABO-incompatible hematopoietic stem cell transplant (HSCT). (nature.com)
- The aim of this work was to analyse the incidence and severity of infections and mortality in relation to the MBL2 genotype and MBL levels in patients underwent allogeneic haematopoietic stem cell transplantation (Allo-HSCT). (unican.es)
- Conclusions: Patients who underwent Allo-HSCT with low pre-transplant MBL levels presented the first episode of infection earlier and had an increased risk of viral infections and mortality in the first 6 months post-transplant. (unican.es)
- Haematopoietic stem cell transplantation (HSCT) is a highly specialised procedure used to treat malignancies of the lymphohaematopoietic system as well as some acquired and inherited disorders of the blood. (smw.ch)
- Haematopoietic stem cell transplantation (HSCT) has become an established treatment option for a wide range of haemato-oncological tumours, some solid tumours, and nonmalignant diseases such as bone marrow failure, primary immunodeficiencies and other congenital and acquired disorders [1- (smw.ch)
- The haematopoietic system is replaced in the form of haematopoietic stem cells from either the patients themselves (autologous HSCT) or other persons (allogeneic HSCT). (smw.ch)
- Autologous HSCT is used to bridge haematopoietic failure during high-dose chemotherapy for the treatment of tumours of the haematopoietic system and some solid tumours that are adequately sensitive to this treatment. (smw.ch)
- Allogeneic HSCT is used to replace the haematopoietic system in patients with acquired or congenital haematopoietic failure, and more commonly to exploit the graft versus tumour effect of allogeneic cells in malignant disease [1- (smw.ch)
- Historically, in allogeneic HSCT marrow-ablative doses of chemotherapy and total-body irradiation were thought to be necessary to eradicate malignancy, to provide immunosuppression in the recipient, and to create space in the stem cell compartment, allowing engraftment of donor haematopoietic cells. (smw.ch)
- The reduction in toxicity with RIC results in less morbidity and mortality, and has made allogeneic HSCT available to patients with comorbidities and to older patients (i.e., patients aged 60 to 70 years, the age group that has the highest prevalence of most haematopoietic malignancies). (smw.ch)
- It is important to note, however, that while the United States Food and Drug Administration (FDA) have approved hematopoietic stem cell transplantation (HSCT) for use against cancer , it is not yet approved for wider use. (medicalnewstoday.com)
- Allogeneic HSCT requires a donor to supply suitable stem cells. (medicalnewstoday.com)
- Autologous HSCT avoids the issue of trying to find a matching donor because stem cells are harvested from the patients themselves. (medicalnewstoday.com)
- In this database of 530 patients who received allo-HSCT between 1990 and 2017, 15 developed solid cancers with a median interval of 3487 days after transplantation. (springer.com)
- 3 Hematopoietic allogeneic stem cell transplantation (HSCT) has the potential to cure PKD. (haematologica.org)
- In order to achieve this goal queries were sent to national and international databanks, including the European Society for Blood and Marrow Transplantation (EBMT), the Center for International Blood and Marrow Transplant Research (CIBMTR), and the National Institute of Health (NIH), as well as to physicians known to be involved in HSCT in PKD patients. (haematologica.org)
- Albany, NY -- ( SBWIRE ) -- 05/11/2017 -- The competitive landscape in the global market for hematopoietic stem cell transplantation (HSCT) is characterized by the rivalry between the leading market players, such as Regen Biopharma Inc., Cryo-Save AG, Pluristem Therapeutics Inc., and CBR Systems Inc., finds a new research study by Transparency Market Research (TMR). (sbwire.com)
- Get accurate market forecast and analysis on the Global Hematopoietic Stem Cell Transplantation (HSCT) Market. (sbwire.com)
- This two (2) day program is designed for Registered Nurses and Nurse Practitioners caring for patients undergoing Hematopoietic Stem Cell Transplantation (HSCT). (mskcc.org)
- 6 We describe herein a case of coinfection due to S. stercoralis and CMV in a patient who underwent allogeneic hematopoietic stem-cell transplantation (allo-HSCT) for HTLV-1-associated peripheral T-cell lymphoma. (lww.com)
- A 60-year-old woman originally from Jamaica with HTLV-1-associated peripheral T-cell lymphoma presented 62 days post-allo-HSCT, with a 2-day history of epigastric pain and diarrhea. (lww.com)
- The most established stem cell medical treatment is hematopoietic stem cell transplantation (HSCT) therapy. (regmednet.com)
- Recognizing this challenge to estimating rates of HSCT graft failure, the current best estimate is about 5% overall, based in part on the need for second and even third transplants in treated patients (Wolff, 2002). (regmednet.com)
- 2013). However, surprisingly, HSCT continues to be practiced around the world without the benefit of knowing the dose of HSCs transplanted. (regmednet.com)
- So, amazingly, although the dose of transplanted HSCs is one of the most important factors for success in HSCT, this metric is barely mentioned in tens of thousands of reports on HSCT biomedical research that span nearly a half-century. (regmednet.com)
- Standardized minimal levels for CD34 cell and TNC counts have been established to keep graft failure rates in the range of 1-5%, even with cord blood HSCT (Rich, 2015). (regmednet.com)
- Depression, fatigue, and pain are prevalent and distressing quality of life concerns for individuals recovering from hematopoietic stem cell transplantation (HSCT). (aacrjournals.org)
- The ZOE-HSCT study succeeded in its primary objective by demonstrating an efficacy of 68.17% [95%CI: 55.56 - 77.against shingles in subjects above 18 years of age after receiving an autologous haematopoietic stem cell transplant. (gsk.com)
- Although haematopoietic stem cell transplant (HSCT) recipients have an increased risk of infection, as a result of severe cellular immunity suppression, Mycobacterium tuberculosis infections are rare. (ecancer.org)
- We present a case of tuberculosis (TB) reactivation after an allogeneic HSCT with isolated lymph node involvement, which mimics other post-transplant complications and makes the diagnosis difficult. (ecancer.org)
- This study examines the short- and long-term QOL benefits of a music therapy intervention for patients recovering from hematopoietic stem cell transplantation (HSCT). (hindawi.com)
- Hematopoietic stem cell transplantation (HSCT) is a medically complex modality that can offer a chance of cure to children with both malignant and nonmalignant conditions. (dana-farber.org)
- and provide updates on important viral infections after hematopoietic stem cell transplant (HSCT). (mdpi.com)
- In contrast, HHV6-associated encephalitis is an emerging syndrome in transplant recipients, especially those undergoing allogeneic hematopoietic stem-cell transplantation (HSCT). (ajnr.org)
- Chronic myeloid leukemia is a myeloproliferative disorder that may be treated with hematopoietic stem cell transplantation (HSCT). (hindawi.com)
- Cases of donor-derived acute myeloid leukemia (AML) or MDS after HSCT or solid tumor transplantation have been published. (hindawi.com)
- Determine the feasibility of maintaining optimal ART in HIV-1 infected patients during allogeneic hematopoietic stem cell transplant (HSCT). (knowcancer.com)
- Recently, MN has been considered to be a possible presentation of chronic graft-versus-host disease (GVHD) of the kidney in allogeneic hematopoietic stem cell transplantation (HSCT) patients. (biomedcentral.com)
- Allogeneic hematopoietic stem cell transplantation (HSCT) reverses the bone marrow failure syndrome due to GATA2 deficiency. (unboundmedicine.com)
- We conducted a case-control study of 18 US transplant recipients with Rhodococcus infection and 36 matched controls. (cdc.gov)
- Our knowledge of disease characteristics among transplant recipients is limited to case reports ( 3 - 8 ). (cdc.gov)
- With the increase in organ transplantation and improved survival of transplant recipients, the incidence of disease will likely increase in the coming years. (cdc.gov)
- BO has been studied most extensively in lung transplant recipients, where it is considered to represent chronic lung rejection. (clinicaltrials.gov)
- Anti-Pneumocystis Prophylaxis to Prevent Nocardia Infection in Hematopoietic Stem Cell Transplant Recipients. (bioportfolio.com)
- Transplant Recipients. (bioportfolio.com)
- We read with interest the recent paper by Molina and coworkers, who studied the relationship between anti-Pneumocystis prophylaxis and Nocardia infections in allogeneic hematopoietic stem cell transplant recipients. (bioportfolio.com)
- Pneumocystis jirovecii pneumonia prophylaxis in allogeneic hematopoietic cell transplant recipients: can we always follow the guidelines? (bioportfolio.com)
- Pneumocystis jirovecii pneumonia (PCP) is a life-threatening disease in allogeneic hematopoietic cell transplantation (HCT) recipients. (bioportfolio.com)
- Infection is the leading cause of morbidity and mortality in immunocompromised patients such as hematopoietic/solid organ transplant recipients and individuals with human immunodeficiency virus. (nih.gov)
- Recipients of stem cell transplants may be severely immunocompromised for many months after transplantation, especially if they are still taking immunosuppressive drugs. (cmaj.ca)
- In this article we aim to familiarize primary care practitioners with some of the basics of allogeneic and autologous transplantation, as well as issues relevant to the care of transplant recipients over the short and the long term. (cmaj.ca)
- What is the clinical significance of positive blood cultures with Aspergillus sp in hematopoietic stem cell transplant recipients? (nih.gov)
- HLA-haploidentical transplantation utilizing post-transplant cyclophosphamide achieves comparable survival to HLA-matched transplantation and has thereby expanded the option of allogeneic transplantation to the vast majority of eligble recipients. (springer.com)
- In this review, we discuss the incidence of respiratory syncytial viral infections, risk factors associated with progression from upper respiratory tract infection to lower respiratory tract infection, other complications and outcomes (including mortality), management strategies, and prevention strategies in patients with a hematologic malignancy and in hematopoietic cell transplant recipients. (haematologica.org)
- The outcomes of these infections vary on the basis of the patient population, with adverse outcomes having been described in hematopoietic cell transplant (HCT) recipients and patients with a hematologic malignancy (HM). (haematologica.org)
- 2,3 Furthermore, recipients have a higher nonrelapse mortality if CMV reactivation occurs less than 100 days after transplantation. (hematology.org)
- Despite these advances, several studies have shown that recipients who are CMV-seropositive remain at risk for worse OS and increased transplant-related mortality. (hematology.org)
- Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients. (webmd.com)
- Cyclosporine dose reduction by ketoconazole administration in renal transplant recipients. (webmd.com)
- Increased cyclosporine levels as a result of simultaneous fluconazole and cyclosporine therapy in renal transplant recipients: a double- blind, randomized pharmacokinetic and safety study. (webmd.com)
- At the forefront of research to increase access to hematopoietic stem cell transplantation and improve outcomes, the Center has amassed a clinical database containing information on nearly 350,000 transplant recipients. (ascopost.com)
- PTLD developed in 78 recipients, with 64 cases occurring less than 1 year after transplantation. (semanticscholar.org)
- Of the 48 cell lines they created, 14 had activity in the lab against all five viruses and, importantly, none showed alloreactivity against the recipients, Leen and colleagues reported. (medpagetoday.com)
- Participants (24 allogeneic and 68 autologous transplant recipients) completed well-validated measures of depressive symptoms, fatigue, and pain prior to transplant and 30, 100, and 200 days post-transplant. (aacrjournals.org)
- Results indicated that depression and fatigue were most severe 30 days post-transplant, with allogeneic recipients showing markedly slower improvement than autologous recipients at later assessments. (aacrjournals.org)
- The immune systems of these stem cell transplant recipients is substantially weakened compared to the general older adult populations studied in other Shingrix efficacy trials," Emmanuel Hanon, Senior Vice President and Head of Vaccines R&D for GSK said. (gsk.com)
- Dr. Knight's research program aims to investigate biological risk and interventions - both pharmacologic and behavioral - for social health disparities in cancer, specifically among hematopoietic stem cell transplant (HCT) and cellular therapy recipients. (mcw.edu)
- Optimizing the prevention and management of infectious diseases by using the best available evidence will contribute to better outcomes for stem cell transplant recipients, and provide the best possible "safety net" for these immunocompromised hosts. (mdpi.com)
- But to keep the body's immune system from rejecting the transplant, recipients must take drugs that suppress their immune system for the rest of their lives. (roche.com)
- HRD recipients received high-dose post-transplant cyclophosphamide (PTCy) followed by tacrolimus and mycophenolate mofetil. (unboundmedicine.com)
- 4.4 For cryopreservation donations, test for COVID‑19 at the assessment and again at harvest of stem cells or donor lymphocytes. (nice.org.uk)
- In the case of transplants using HSC derived from other people, the conditioning therapy also helps reduce the risk of the recipient's body killing or rejecting the incoming donor stem cells (graft rejection). (thedailystar.net)
- Accurate determination of immune system compatibility is vital to minimise graft failure and lethal attack from donor cells against recipient's normal tissues (graft-versus-host disease or GvHD). (thedailystar.net)
- In the case of allogeneic transplant, the patient's donor will also have to undergo an assessment. (thedailystar.net)
- In 2014, according to the World Marrow Donor Association , stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). (wikipedia.org)
- The usual odds ratio is 1 out of 100 CBUs that meet donor-recipient eligibility/match criteria and are transplanted. (frontiersin.org)
- Cord blood units, unlike adult donor stem cell collection/harvests, are readily available on demand. (frontiersin.org)
- The choice between the more risky allogeneic transplant and an autologous procedure depends on patient age, the underlying disease, donor availability and institutional preference ( Box 1 ). (cmaj.ca)
- Allogeneic transplantation represents 40% of all stem cell transplants performed annually in Canada and requires donor and recipient matching for major histocompatibility (HLA) antigens. (cmaj.ca)
- Blood stem cell transplantation is accomplished by treating the donor with hematopoietic growth factors, which cause the stem cells to proliferate and circulate freely in the peripheral blood. (cmaj.ca)
- Fig. 1: Collection of stem cells by direct aspiration from bone marrow, with the donor under general anesthetic. (cmaj.ca)
- and (2) allogeneic (patient receives healthy donor bone marrow, peripheral blood stem cells or umbilical cord/placental blood to restore normal marrow/immune function where it is deficient, allow otherwise potentially lethal intensive anti-cancer treatment, and provide alloreactivity that may eliminate minimal residual malignant disease). (renalandurologynews.com)
- Collecting stem cells provides a bigger graft, and does not require that the donor be subjected to general anesthesia to collect the graft. (citizendium.org)
- To avoid rejection of the transplanted stem cells or severe graft-versus-host disease , the donor should have the same human leukocyte antigens (HLA) as the recipient. (citizendium.org)
- When added to the standard drug regimen used to prevent GVHD, abatacept reduced the occurrence of acute, grade III-IV GVHD from 32% to 3% in pediatric and adult patients who underwent mismatched unrelated donor stem cell transplants to treat advanced cancer and other blood disorders. (ascopost.com)
- For patients receiving cells from an unrelated donor, the rate of mild-to-severe forms of acute GVHD can reach as high as 80%, with up to half of patients dying from the most severe forms. (ascopost.com)
- In their models, abatacept reduced the proliferation and activation of effector T cells, which incite GVHD when they become overactive as the patient's immune system starts to rebuild itself from the donor stem cells. (ascopost.com)
- A study by MacMillan et al reported that alternative donor hematopoietic cell transplantation had a high success rate in patients with Fanconi anemia who did not have a history of opportunistic infections or transfusions and who underwent conditioning with single fraction total body irradiation 300 cGy, cyclophosphamide, fludarabine, and antithymocyte globulin. (medscape.com)
- A study by Wang et al suggested that in patients with Fanconi anemia, the 1-year overall survival rate following unrelated-donor hematopoietic stem cell transplantation is poor in those with clonal or complete copy gains in the q arm of chromosome 3 or with abnormalities in three or more chromosomes. (medscape.com)
- The effect of pre-transplant ferritin (PTF) and recipient and donor age on CPE were analyzed in the two groups. (sciencepg.com)
- Haploidentical stem cell transplantation (haploSCT) from a first-degree-related haplotype-mismatched donor (siblings, children, parents) could expand allogeneic stem cell transplantation (SCT) to a large proportion of patients with hematologic malignancies without an HLA-matched donor ( 1 ). (mhmedical.com)
- In contrast to unrelated donor stem cells, haploidentical (or "half-matched") donors can be available immediately, and there are no costs associated with an unrelated donor search, maintaining a registry, or coordinating logistics with distant donor centers. (mhmedical.com)
- This approach might also be particularly useful in developing countries that may not have the resources to procure unrelated donor transplants or maintain complex unrelated donor registries. (mhmedical.com)
- Moreover, haploidentical donors offer the possibility to easily collect donor cells for cellular therapy posttransplant. (mhmedical.com)
- Improved haploidentical transplant outcomes represent a major advance in SCT that has practically eliminated the limitation of donor availability for allogeneic SCT. (mhmedical.com)
- Effector T cells incite GvHD when they become overactive as the patient's immune system starts to rebuild itself from the donor stem cells. (seattlechildrens.org)
- The second cohort of 140 patients with human leukocyte antigen-matched unrelated donor transplants completed enrollment in November 2017, with data expected from this randomized double-blind arm of the study in the next six months. (seattlechildrens.org)
- There must be appropriate statistical techniques in the analysis to control for selection bias and potential confounding by age, duration of diagnosis, comorbid conditions, type of preparative/conditioning regimen, graft vs. host disease (GVHD) prophylaxis, donor type and cell source. (cms.gov)
- We report a case of PRCA following a matched sibling donor allogeneic PBSC transplant (PBSCT) with a bidirectional ABO mismatch. (nature.com)
- He had uneventful engraftment of neutrophils and platelets, with absolute neutrophil and platelet count's exceeding 0.5 × 10 9 and 20 × 10 9 /L on D+13 and D+19, respectively, and a 100% donor chimerism at 1 month post transplant. (nature.com)
- These data are put in correlation with donor availability from international registries and with number of transplant teams and number of procedures per team all corrected for population size. (smw.ch)
- He has an HLA-matched related donor (his brother) who agrees to donate hematopoietic cells for an allogeneic transplant. (hematology.org)
- and 2) the donor cells did not have the delta 32 mutation that results in CD4 receptors that are CCR5 negative in new cells (conferring resistance to re-infection by HIV). (healio.com)
- It is interesting the investigators hypothesize that following the allogeneic bone marrow transplants that graft vs host disease (ie, donor cells killing host cells), in combination with ongoing ART, led to the potential eradication of HIV in these two patients. (healio.com)
- The Berlin patient, who was the first reported case of cure, received a form of gene therapy by receiving a bone marrow transplant from a donor with a favorable genetic mutation. (healio.com)
- The Center for International Blood and Marrow Transplant Research is a combined research program of the National Marrow Donor Program and the Medical College of Wisconsin, Milwaukee. (ascopost.com)
- New reduced-intensity preparative regimens cause considerably less morbidity and mortality, but are still sufficiently immunosuppressive to allow donor cells to engraft. (ascopost.com)
- And we are able to do alternative-donor transplants with an acceptable rate of graft-vs-host disease and transplant-related mortality. (ascopost.com)
- For people needing an organ transplant, testing provides essential information about the urgency of the need for the organ, the patient's blood and tissue type, and body size - this data helps the donor computer programme find the best match. (roche.com)
- CMV testing plays a vital role for both the patient needing the transplant and the donor. (roche.com)
- When a donor organ becomes available, another CMV test takes place hours before surgery so that the transplant team has the most current information about the patient's CMV status. (roche.com)
- The pre-transplant test is a blood (serology) test that identifies whether the donor or patient receiving the transplant has already been infected with CMV and provides information about the level of potential risk to the recipient from the virus (see chart). (roche.com)
- Stem cells are removed from another person, called a donor. (medlineplus.gov)
- Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
- The red blood cells are returned to the donor. (medlineplus.gov)
- Further insight into humoral viral immunity after hematopoietic cell transplantation (HCT) could have potential impact on donor selection or monitoring of patients. (bloodjournal.org)
- While posttransplantation relapse of disease resulting from a failure to eradicate the patient's original leukemia could occur, patients may also rarely develop a secondary malignancy or myelodysplastic syndrome (MDS) of donor origin termed donor cell leukemia (DCL). (hindawi.com)
- However, patients may also rarely develop a secondary malignancy or myelodysplastic syndrome of donor origin termed donor cell leukemia (DCL) [ 3 ]. (hindawi.com)
- Posttransplantation donor-derived multiple myeloma is an exceedingly rare phenotype of DCL that has been reported following solid organ transplantation of the heart, lungs, and kidneys [ 5 - 7 ]. (hindawi.com)
- Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK deficiency. (cancer.gov)
- Haploidentical related donor hematopoietic stem cell transplantation for DOCK8 deficiency using post-transplant cyclophosphamide. (cancer.gov)
- The BMDW Editorial Board consists of one representative of each stem cell donor registry or cord blood bank participating in BMDW, and meets twice a year to discuss achievements and necessary improvements. (wikipedia.org)
- BMDW participants consist of 75 hematopoietic cell donor registries from 53 countries, and 53 cord blood banks from 36 countries. (wikipedia.org)
- Search & Match tool: The BMDW provides a fast preliminary search tool to find the best matched stem cell donor or cord blood unit for a patient in need of a transplant. (wikipedia.org)
- The tool is primarily intended for use by professionals in the field of stem cell transplantation with profound knowledge of HLA, such as search coordinators and transplant physicians from transplant centres, stem cell donor registries, and cord blood banks. (wikipedia.org)
- BMDW's mission is to create a comprehensive, fair, and equitable global list of unrelated stem cell donors and cord blood products that shall allow fast determination of whether a matched donor is available for a patient in need of a hematopoietic stem cell transplant. (wikipedia.org)
- For the journal abbreviated Bone Marrow Transplant , see Bone Marrow Transplantation (journal) . (wikipedia.org)
- In 2006, 50,417 first HSCTs were recorded worldwide, according to a global survey of 1,327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
- The Worldwide Network for Blood and Marrow Transplantation reported the millionth transplant to have been undertaken in December 2012. (wikipedia.org)
- In 2006 a total of 50,417 first hematopoietic stem cell transplants were reported as taking place worldwide, according to a global survey of 1327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
- Bone marrow transplantation was first attempted, albeit unsuccessfully, in 1939, when human bone marrow cells were injected intravenously to treat a patient with aplastic anemia. (cmaj.ca)
- Bone marrow transplantation was pioneered at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s by E. Donnall Thomas , whose work was later recognized with a Nobel Prize in Physiology and Medicine. (citizendium.org)
- A major limitation of allogeneic bone marrow transplantation is a shortage of donors. (citizendium.org)
- Hemopoietic stem cell transplantation in thalassemia: a report from the European Society for Blood and Bone Marrow Transplantation Hemoglobinopathy Registry, 2000-2010. (sciencepg.com)
- When given on days 3 and 4 after HLA-haploidentical T-cell replete blood or marrow transplantation, high-dose cyclophosphamide depletes dividing alloreactive T-cells, resulting in low rates of acute graft -versus- host disease, comparable to HLA-matched transplantation, and chronic graft -versus- host disease incidence below that seen with T-cell replete HLA-matched transplantation. (springer.com)
- Mismatched family donors for bone-marrow transplantation as treatment for acute leukaemia. (springer.com)
- Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma. (springer.com)
- Marrow transplantation from related donors other than HLA-identical siblings. (springer.com)
- Solid cancers after bone marrow transplantation. (springer.com)
- Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study. (semanticscholar.org)
- We evaluated 18,014 patients who underwent allogeneic bone marrow transplantation (BMT) at 235 centers worldwide to examine the incidence of and risk factors for posttransplant lymphoproliferative disorders (PTLD). (semanticscholar.org)
- Real-World Issues and Potential Solutions in Hematopoietic Cell Transplantation during the COVID-19 Pandemic: Perspectives from the Worldwide Network for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research Health Services and International Studies Committee. (dana-farber.org)
- Biol Blood and Marrow Transplantation. (cancer.gov)
- Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, vol. 24, no. 6, 2018, pp. 1250-1259. (unboundmedicine.com)
- Is There Any Reason to Prefer Cord Blood Instead of Adult Donors for Hematopoietic Stem Cell Transplants? (frontiersin.org)
- Allogeneic transplant donors may be related (usually a sibling) or unrelated volunteers. (citizendium.org)
- In the cohort of patients who received transplants from mismatched unrelated donors, all 43 patients received four doses of abatacept with a calcineurin inhibitor and methotrexate. (ascopost.com)
- Related transplant donors must be proven not to have Fanconi anemia in order for a transplantation to succeed. (medscape.com)
- The survival rate after transplantation from alternative donors is improving, depending on the completeness of the HLA-matching. (medscape.com)
- Partially HLA-mismatched related (HLA-haploidentical) donors can be identified for the vast majority of patients, but transplants from these donors have historically been limited by excessive graft -versus- host disease, nonrelapse mortality, and poor overall survival. (springer.com)
- Results of allogeneic bone marrow transplants for leukemia using donors other than HLA-identical siblings. (springer.com)
- Differences in transplant rates, in rates for particular indications, and in the use of specific transplant technologies such as use of unrelated donors, use of cord blood or mismatched family donors are described. (smw.ch)
- Significant improvement in survival after allogeneic hematopoietic cell transplantation during a period of significantly increased use, older recipient age, and use of unrelated donors. (springer.com)
- The two patients had received reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation from wild-type CCR5 donors. (healio.com)
- This is particularly true in the area of allogeneic transplantation, where the major barriers to widespread use were the toxicity associated with high-dose chemotherapy and radiation given beforehand, and the high risk of graft-vs-host disease, especially when using donors other than human leukocyte antigen (HLA)-identical siblings. (ascopost.com)
- The number of viruses recognized by a given cell line was correlated with the donors' age, they reported, possibly a reflection of exposure to a larger number of pathogens in older donors. (medpagetoday.com)
- Bone Marrow Donors Worldwide (BMDW) is an organization based in Leiden, Netherlands, that coordinates the collection of the HLA phenotypes and other relevant data of volunteer hematopoietic cell donors (used to perform what used to be called bone marrow transplants, but now referred as hematopoietic cell transplants) and cord blood units across the globe. (wikipedia.org)
- Joining BMDW database requires a registry to be fully operational, and must have at least 50 HLA-typed unrelated stem cell donors or cord blood units. (wikipedia.org)
- The BMDW is the world's largest hematopoietic cell database, listing more than 29.5 million stem cell donors and over 721,289 cord blood units. (wikipedia.org)
- These global hematopoietic cells from donors or cord blood units are used to transplant patients around the world with a variety of with life-threatening blood disorders such as leukemia, lymphoma, aplastic anemia, as well as certain immune system and metabolic disorders. (wikipedia.org)
- The purpose of BMDW still remains the same, to collect the HLA phenotypes of volunteer stem cell donors and cord blood units and to co-ordinate their worldwide distribution. (wikipedia.org)
- Other conditions treated with stem cell transplants include sickle-cell disease , myelodysplastic syndrome , neuroblastoma , lymphoma , Ewing's sarcoma , desmoplastic small round cell tumor , chronic granulomatous disease , Hodgkin's disease and Wiskott-Aldrich syndrome . (wikipedia.org)
- Other conditions that bone marrow transplants are considered for include thalassemia major , sickle-cell disease , myelodysplastic syndrome , lymphoma , Hodgkin's disease , and multiple myeloma . (citizendium.org)
- They also allow us to consider transplantation in other disorders where high transplant-related mortality rates were previously considered prohibitive-for example, in people with severe sickle cell disease or autoimmune disease. (ascopost.com)
- Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide. (dana-farber.org)
- How to Improve Cord Blood Transplantation: By Enhancing Cell Counts or Engraftment? (frontiersin.org)
- Efforts to increase stem cell content or engraftment rate of the graft by ex vivo expansion, modulation by molecules such as fucose, prostaglandin E2 derivative, complement CD26 inhibitors, or CXCR4/CXCL12 axis have been able to accelerate engraftment speed and rate. (frontiersin.org)
- 7 The use of blood stem cells is associated with faster recovery of neutrophils and platelets after transplantation (engraftment) than is the case with bone marrow stem cells. (cmaj.ca)
- This section describes the 4 components of allogeneic transplantation - conditioning, transplantation, engraftment and immunoreconstitution ( Fig. 2 ) - and provides information about the patient's hospital stay and the risks associated with this type of transplantation. (cmaj.ca)
- The study, which involved 130 patients, also found that adding fludarabine to conditioning caused three-fold enhancement of hematopoietic cell engraftment. (medscape.com)
- 2 Delivery of α- L -iduronidase may be achieved by either the exogenous administration of α- L -iduronidase or through the endogenous production of α- L -iduronidase following stable engraftment of cells producing enzyme within the affected individual. (nature.com)
- Engraftment syndrome following hematopoietic stem cell transplantation. (springer.com)
- Non-myeloablative conditioning regimens achieve engraftment without eradication of host hematopoietic cells, which potentially allows for protection against infections commonly seen in hematopoietic cell transplantation patients treated with standard intensity conditioning regimens. (haematologica.org)
- 9 - 11 Non-myeloablative conditioning regimens achieve engraftment with less toxicity and host hematopoietic cells are not immediately eradicated. (haematologica.org)
- The goal was to promote engraftment and let the graft versus tumour effect eliminate tumour cells. (smw.ch)
- Mixed T-cell chimerism at engraftment and absence of chronic graft versus host disease (cGVHD) were associated with relapse (P = 0.04 and P = 0.02, respectively). (luriechildrens.org)
- Mixed T-cell chimerism at engraftment was predictive in patients without cGVHD (P = 0.03). (luriechildrens.org)
- Patients with engraftment mixed T-cell chimerism may warrant closer disease monitoring and consideration for early intervention. (luriechildrens.org)
- Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
- The previous experience among pediatric patients have now expanded to adults, and the number of CB transplants has reached 30,000. (frontiersin.org)
- Other patients who receive bone marrow transplants include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia and was born with defective stem cells. (citizendium.org)
- A Retrospective Cohort Analysis to Determine the Incidence of CMV Viremia and Progression to CMV Disease in Pediatric Patients Receiving Allogeneic Hematopoietic Cell Transplantation at an Academic Children's Hospital. (upenn.edu)
- Improving and Standardizing the Recognition and Documentation of Malnutrition for Inpatient Pediatric Oncology and Stem Cell Transplant. (upenn.edu)
- Successful treatment of Pulmonary Mucormycosis in Two Pediatric Hematopoietic Cell Transplant Patients. (upenn.edu)
- Pediatric Transplantation February 2018 Notes: (Accepted for publication, February 2018). (upenn.edu)
- Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist-Oncologist, 1st Edition: Elsevier Health Sciences 2018. (upenn.edu)
- In 1998, she became medical director of the Pediatric Transplant Unit at Children's Hospital and, in 2007, was appointed clinical director of the Pediatric Stem Cell Transplant Program. (dana-farber.org)
- We have also worked to characterize the chronic pulmonary conditions associated with allogeneic transplant in the pediatric setting and, in conjunction with our colleagues in dental medicine, described the oral manifestations of graft-versus-host disease (GVHD). (dana-farber.org)
- Risk factors for transplant-associated thrombotic microangiopathy and mortality in a pediatric cohort. (dana-farber.org)
- The use of interval-compressed chemotherapy with the addition of vincristine, irinotecan, and temozolomide for pediatric patients with newly diagnosed desmoplastic small round cell tumor. (childrenshospital.org)
- We identified 144 patients in the study period, of which 115 patients were eligible for the study because they received an allogeneic transplant, of these 115 cases, 41 patients were excluded due to that they did not achieve the graft for the reasons that are specified in the results section, leaving 74 patients for the final analysis. (scirp.org)
- Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft. (semanticscholar.org)
- In the allogeneic setting, graft-versus-host disease may also develop, making post-transplant management complex. (cmaj.ca)
- Graft source (cord blood, bone marrow or peripheral blood stem cells) which may impact on speed to marrow recovery. (renalandurologynews.com)
- Autologous transplants have the advantage of a lower risk of graft rejection, infection and graft-versus-host disease. (citizendium.org)
- This case series describes 7 patients with severe chronic graft-versus-host disease (cGvHD) associated with bronchiolitis obliterans (BO) after allogeneic hematopoietic stem cell transplantation (HCT) who underwent lung transplantation. (transplantnow.com)
- At 100 days post-transplant, the cumulative incidence of grade III to IV acute graft-vs-host disease (GVHD) occurred in 3% of patients receiving abatacept compared to 32% receiving calcineurin inhibitor and methotrexate (CNI/MTX) and 22% receiving CNI/MTX plus antithymocyte globulin (+ATG). (ascopost.com)
- Results from a phase II clinical trial presented by Kean et al at the 59th American Society of Hematology (ASH) Annual Meeting ( Abstract 212 ) show that the drug abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GVHD) in patients receiving hematopoietic stem cell transplants. (ascopost.com)
- Given the serious threat of graft-vs-host disease, new approaches to make stem cell transplants safer for patients remain a critical unmet need," said Leslie Kean, MD, PhD , the trial's principal investigator and Associate Director of the Ben Towne Center for Childhood Cancer Research at Seattle Children's. (ascopost.com)
- Preventing graft-vs-host disease and relapse after transplant requires a difficult balance of eliminating the bad, overactive effector T-cells, without suppressing the good, regulatory T-cells," said Dr. Kean, who is also Associate Professor of Pediatrics at the University of Washington School of Medicine and a member of the Fred Hutchinson Cancer Research Center . (ascopost.com)
- Historically, unmanipulated T-cell-replete haploSCT grafts with conventional graft-versus-host-disease (GVHD) prophylaxis used in the late 1970s were associated with intense bidirectional alloreactivity and unacceptably high morbidity and mortality rates due to hyperacute GVHD and graft rejection ( 4 , 5 , 6 ). (mhmedical.com)
- Graft-versus-host disease occurs when the donated T cells, white blood cells in the immune system that fight infection, launch a vigorous attack on a patient's organs, including the skin, liver, kidneys, lung, and the gastrointestinal tract. (seattlechildrens.org)
- As a transplant physician, it's beyond heartbreaking to witness a patient develop severe acute graft-versus-host disease after having their leukemia cured through bone marrow transplant," said Kean. (seattlechildrens.org)
- Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease. (springer.com)
- However, graft-versus-host disease and its therapies continue to be significant risk factors for invasive cytomegalovirus and fungal infection in patients undergoing non-myeloablative transplantation, particularly in the late period after conditioning. (haematologica.org)
- Continuing increased risk of oral/esophageal cancer after allogeneic hematopoietic stem cell transplantation in adults in association with chronic graft-versus-host disease. (springer.com)
- 2013). Patient survival in each treatment setting is dependent on many other factors besides the efficiency of establishing a good HSC transplant graft that restores effective hematopoiesis. (regmednet.com)
- These long-lasting T cell deficiencies have been shown to play a direct role in post-transplant complications. (clinicaltrials.gov)
- 5 transplants with only partial matching for HLA antigens are associated with a higher risk of post-transplant complications. (cmaj.ca)
- Intensive care, support and interventions stand to rescue the patient from otherwise fatal complications of therapy and require a high level of collaboration among intensive care and transplant providers. (renalandurologynews.com)
- Day post-transplant, which will impact on complications likely to occur, types of infections likely and expectation of timing for marrow recovery. (renalandurologynews.com)
- Chapter 18: "Infectious Complications in Hematopoietic Stem Cell Transplant. (upenn.edu)
- Mycobacterium tuberculosis infections are uncommon complications in the haematopoietic stem cell post-transplant period. (ecancer.org)
- With respect to decreasing the acute complications of transplant, we have examined the role of defibrotide, an agent that is effective in treating patients with severe veno-occlusive disease of the liver, and explored how to best address the nutritional needs of our patients. (dana-farber.org)
- She tolerated the transplant without complications and was in remission until January 2012 when routine blood work identified increased serum protein and anemia. (hindawi.com)
- Therapeutic Impact and Complications Associated with Surgical Lung Biopsy after Allogeneic Hematopoietic Stem Cell Transplantation in Children. (childrenshospital.org)
- Hematopoietic cell transplantation (HCT) provides a life-prolonging or potentially curative treatment option for patients with hematologic malignancies. (nccn.org)
- New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors. (springer.com)
- These advances make transplantation a viable treatment for many more patients with hematologic malignancies. (ascopost.com)
- Malignancies after hematopoietic cell transplantation for primary immune deficiencies: a report from the Center for International Blood and Marrow Transplant Research. (semanticscholar.org)
- CD133 allows elaborated discrimination and quantification of haematopoietic progenitor subsets in human haematopoietic stem cell transplants. (semanticscholar.org)
- Tunneling nanotubes mediate the transfer of stem cell marker CD133 between hematopoietic progenitor cells. (semanticscholar.org)
- Age-Related Increase of EED Expression in Early Hematopoietic Progenitor Cells is Associated with Global Increase of the Histone Modification H3K27me3. (semanticscholar.org)
- CB progenitor/stem cell content has been compared with adult stem cells revealing higher long-term repopulating capacity compared to bone marrow-mesenchymal stromal cells and lesser oncogenic potential than progenitor-induced stem cells. (frontiersin.org)
- Newswise - Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease. (newswise.com)
- Human hematopoietic stem and progenitor cells (HSPCs), derived from bone marrow, have become a primary vehicle for efforts to replace or regenerate cells destroyed by a variety of diseases. (newswise.com)
- Natural gas in spanish More recently, the survey has included additional information on novel cell therapies with hematopoietic stem cells for non-hematopoietic use, as well as on the use of non-hematopoietic stem and progenitor cells. (gaselectricity.in)
- Transplanted cord blood (CB) hematopoietic stem cells (HSC) and progenitor cells (HPC) can treat malignant and nonmalignant disorders. (pnas.org)
Bone marrow transplants1
- The more common way is to collect them from the blood stream, or "peripheral blood stem cell harvesting. (thedailystar.net)
- A subclinical EBV reactivation was observed in 24 cases (19.5%) with EBV-genome copies in 10(5) peripheral blood mononuclear cells ranging between 2,500 and mostly 10,000. (uzh.ch)
- or =80,000 copies/10(5) peripheral blood mononuclear cells and plasma positivity prompted us to start pre-emptive therapy with rituximab and cidofovir for prevention of lymphoproliferative disease. (uzh.ch)
- or =1,000 copies/10(5) peripheral blood mononuclear cells did not develop EBV-associated lymphoproliferative disease. (uzh.ch)
- Peripheral expansion of T cells in a lymphopenic setting leads to a narrowing of the TCR repertoire and manifests as a decrease in the magnitude of response to new antigens. (clinicaltrials.gov)
- The success of haematopoietic stem cell (HSC) transplantation largely depends on numbers of transplanted HSCs, which reside in the CD34(+) populations of bone marrow (BM), peripheral blood stem cells (PBSC) and umbilical cord blood (UCB). (semanticscholar.org)
- Although stem cells can be collected by direct aspiration from the bone marrow, with the patient under general or spinal anesthetic ( Fig. 1 ), they are now more commonly harvested from the peripheral blood. (cmaj.ca)
- Since the early 1990s and the availability of the stem cell growth factors GM-CSF and G-CSF , most hematopoeitic stem cell transplantation procedures have been performed with stem cells collected from the peripheral blood. (citizendium.org)
- Hematopoietic stem cell transplantation (bone marrow, cord blood, or peripheral blood stem cells) may cure aplastic anemia and prevent myelodysplastic syndrome or leukemia. (medscape.com)
- Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. (springer.com)
- The researchers collected peripheral blood mononuclear cells by leukapheresis from both patients and rectal tissue from one patient to quantify HIV DNA and perform viral co-culture from CD4+ T lymphocytes. (healio.com)
- No HIV DNA was detected in any of the peripheral blood mononuclear cells from either patient, suggesting that the peripheral viral reservoir size decreased by 3 log 10 to 4 log 10 . (healio.com)
- Epstein-Barr virus (EBV) load in cerebrospinal fluid and peripheral blood of patients with EBV-associated central nervous system diseases after allogeneic hematopoietic stem cell transplantation. (semanticscholar.org)
- Leen and colleagues derived T cells specific to five viruses -- cytomegalovirus, adenovirus, Epstein-Barr virus, BK virus, and human herpesvirus 6 -- by stimulating peripheral blood mononuclear cells with overlapping peptide libraries of viral antigens. (medpagetoday.com)
- After reduced intensity conditioning with fludarabine (40 mg/m 2 4 days), melphalan (70 mg/m 2 1 day), and thymoglobulin (2.5 mg/kg 3 days), he received a T-cell-replete peripheral blood allograft containing 5.7 × 10 6 CD34 cells/kg. (ecancer.org)
- Autologous transplants have the advantage of lower risk of infection during the immune-compromised portion of the treatment, since the recovery of immune function is rapid. (wikipedia.org)
- Immunosuppressive medications that compromise cell-mediated immunity can predispose to infection ( 1 , 2 ). (cdc.gov)
- The authors concluded that the use of atovaquone may be associated with an increased risk of Nocardia infection after allogeneic hematopoietic stem cell transplantation, as compared with cotrimoxazole. (bioportfolio.com)
- A retrospective cohort study based on data collected from the Department of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatría (INP) from January 1998 to December 2016 was performed to identify if prior infection was a predictive risk factor for aGVHD. (scirp.org)
- The CPE was defined as white blood cell counts less than 3.0×109/L for four weeks or longer without infection of cytomegalovirus, human parvovirus B19 virus and Epstein-Barr virus. (sciencepg.com)
- Patients receiving abatacept had intact immune reconstitution, significant improvement in transplantation-related mortality, no major uncontrolled infection and no increase in disease relapse. (seattlechildrens.org)
- Induction of alloreactive cytotoxic T cells by acute virus infection of mice. (springer.com)
- There have also been numerous reports of outbreaks in bone marrow transplant units and oncology wards, where infection control measures have been invaluable in controlling the spread of disease. (haematologica.org)
- Conclusions Respiratory virus lower tract infection during the first 100 days after hematopoietic cell transplantation was less common in persons receiving non-myeloablative conditioning regimens compared to myeloablative conditioning, despite a similar overall rate of acquisition. (haematologica.org)
- 1 - 5 Though the incidence of these infections in hematopoietic cell transplantation patients usually parallels that in the community, their course can be more severe with progression to lower respiratory tract infection, co-infection with serious pulmonary co-pathogens such as invasive molds, and late airflow decline. (haematologica.org)
- 1000 ng/ml in the pre-transplant period (risk ratio (RR) 2.48, 95% CI 1.00?6.13), neutropenic period (0?30 days, RR 3.28, 95% CI 1.53?7.06) and intermediate period (30?100 days, RR 2.37, 95% CI 1.15?4.90) were associated with increased risk of virus infection. (unican.es)
- What is the optimal approach to prevent CMV infection in patients undergoing allogeneic hematopoietic cell transplantation (AHCT) in 2018? (hematology.org)
- All of the patients who got the cells prophylactically -- between 38 and 43 days after transplant -- remained free of infection by all of the viruses for more than 3 months, Leen and colleagues reported. (medpagetoday.com)
- Transplant patients are among those most vulnerable to CMV infection, especially in the critical few months after the transplant. (roche.com)
- Between 20% and 60% of people with a solid organ transplant develop a symptomatic CMV infection 4 . (roche.com)
- Doctors believe that for many cancers, the donor's white blood cells may attack any remaining cancer cells, similar to when white cells attack bacteria or viruses when fighting an infection. (medlineplus.gov)
- Importantly, cyclophosphamide spares non-alloreactive T-cells, preserving immunity and leading to a low incidence of nonrelapse mortality after HLA-haploidentical transplantation. (springer.com)
- Secondary solid cancers after allogeneic hematopoietic cell transplantation using busulfan-cyclophosphamide conditioning. (springer.com)
- Each of the following patients had undergone myeloablative conditioning with cyclophosphamide and total-body irradiation before transplantation and was receiving oral acyclovir for herpesvirus prophylaxis at the time of presentation. (ajnr.org)
- Furthermore, introduction of reduced intensity conditioning protocols, better HLA matching, and recognition of the importance of HLA-C have improved CB transplants success by decreasing transplant-related mortality. (frontiersin.org)
- The effect of pre-transplant factors such as age, disease stage, transfusions, iron parameters and comorbidity on overall survival (OS), non-relapse mortality (NRM), and relapse incidence (RI) was evaluated in 201 patients. (ru.nl)
- Pre-transplant anemia is an independent risk factor for increased mortality following alloHSCT. (ashpublications.org)
- Background Respiratory virus infections are important causes of morbidity and mortality after hematopoietic cell transplantation. (haematologica.org)
- Community-acquired respiratory infections (parainfluenza 1-4, influenza A and B, respiratory syncitial virus, and rhinovirus) are important causes of morbidity and mortality after hematopoietic cell transplantation. (haematologica.org)
- Thus, pre-transplant MBL levels would be important in predicting susceptibility to viral infections and mortality and might be considered a biomarker to be included in the pre-transplantation risk assessment. (unican.es)
- Reduced mortality after allogeneic hematopoietic-cell transplantation. (springer.com)
- Second cancer risk and late mortality in adult Australians receiving allogeneic hematopoietic stem cell transplantation: a population-based cohort study. (springer.com)
- Late mortality and causes of death among long-term survivors after allogeneic stem cell transplantation. (springer.com)
- Once a transplant recipient is discharged from hospital and returns to his or her local community, the primary care physician can play an important role in care. (cmaj.ca)
- The ethnicity/race of the recipient can also limit MUD transplantation as approximately 30% of Caucasians, 70% of Hispanics, and 90% of African Americans do not have a MUD in the worldwide registries ( 3 ). (mhmedical.com)
- Can the negative effect of being a CMV-seropositive transplant recipient be overcome? (hematology.org)
- The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. (medlineplus.gov)
- This is a retrospective cohort study based on data collected from the allogenic transplant performed at the Department of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatría (INP) registered in a database, from January 1998 to December 2016. (scirp.org)
- At the end of 2015, James Sherley, director of stem cell medicine biotechnology company Asymmetrex, listed 9 areas of stem cell medicine that could improve in 2016, if new methods for counting tissue stem cells were employed. (regmednet.com)
- Alternative sources of haematopoietic stem cells, such as HLA mismatched (haplo-identical) family members and cord blood, may be available. (nice.org.uk)
- Another type of HSC source is cord blood cells that are used in umbilical cord blood transplants. (thedailystar.net)
- As cord blood (CB) enables rapid access and tolerance to HLA mismatches, a number of unrelated CB transplants have reached 30,000. (frontiersin.org)
- Such transplant activity has been the result of international accreditation programs maintaining highly qualified cord blood units (CBUs) reaching more than 600,000 CBUs stored worldwide. (frontiersin.org)
- Among many sources of hematopoietic stem cell sources, cord blood (CB) is the one that belongs to the earliest stages of life. (frontiersin.org)
- Allogeneic transplants are also performed using umbilical cord blood as the source of stem cells. (citizendium.org)
- Furthermore, cryopreserved cord blood has become an accepted stem cell source [5-for certain indications. (smw.ch)
- As well as using stem cells from a donor's blood, cells from umbilical cord blood can also be used. (medicalnewstoday.com)
- Umbilical cord blood stem cells are frozen at birth, which is important because they do not suffer any environmental damage or aging. (medicalnewstoday.com)
- As a result, cord blood transplants do not require such a high level of tissue matching. (medicalnewstoday.com)
- HSCs are adult tissue stem cells found naturally primarily in the bone marrow and in umbilical cord blood. (regmednet.com)
- Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. (globenewswire.com)
- Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
- Umbilical cord blood cells are very immature so there is less of a need for perfect matching. (medlineplus.gov)
- Prophylaxis and treatment of Pneumocystis Jirovecii pneumonia after solid organ transplantation. (bioportfolio.com)
- Depletion of naive T cells using clinical grade magnetic CD45RA beads: a new approach for GVHD prophylaxis. (springer.com)
- To test them, the researchers infused between five and 20 million cells into 11 patients, eight of them to treat existing infections -- some multiple -- and three as prophylaxis. (medpagetoday.com)
- The rationale underlying autologous transplantation is to deliver high doses of chemotherapy (with or without radiotherapy). (thedailystar.net)
- Whereas anti-tumour effects rely solely on high-doses of chemotherapy in autologous transplants, allogeneic HSC may also have beneficial immune activity that kills tumour/leukaemia. (thedailystar.net)
- In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. (wikipedia.org)
- More recently non-myeloablative, " "mini transplant (microtransplantation) ," procedures have been developed that require smaller doses of preparative chemotherapy and radiation. (wikipedia.org)
- The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
- Children or adults with aplastic anemia have lost their stem cells after birth and may not require such high doses of chemotherapy and irradiation prior to a transplant. (citizendium.org)
- More recently non-myeloablative, or so-called "mini transplant," procedures have been developed which do not require such large doses of chemotherapy and radiation. (citizendium.org)
- PT-Hb levels were determined within 2 weeks prior to transplantation, after commencing conditioning chemotherapy. (ashpublications.org)
- The cells are cleaned and frozen before being reintroduced to the individual after they receive the chemotherapy drugs. (medicalnewstoday.com)
- Ablative (myeloablative) treatment -- High-dose chemotherapy, radiation, or both are given to kill any cancer cells. (medlineplus.gov)
- Reduced intensity treatment, also called a mini transplant -- Lower doses of chemotherapy and radiation are given before a transplant. (medlineplus.gov)
- Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
- After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
- A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
- A bone marrow transplant replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation. (medlineplus.gov)
- Pre-transplant organ function, including renal, pulmonary and cardiac evaluations, as well as changes in those organ functions since admission. (renalandurologynews.com)
- Yellow fever vaccination in organ transplanted patients: is it safe? (transplantnow.com)
- The two most common types of transplants are solid organ transplants and hematopoietic stem cell transplants 5 . (roche.com)
- People receive solid organ transplants to replace organs that have failed due to disease or injury. (roche.com)
- A solid organ patient's transplant journey is complex. (roche.com)
- Generally, organ transplant patients are tested for CMV at least twice before the transplant. (roche.com)
- The type of transplant also affects the CMV risk - lung, heart and multi-organ transplants carry the highest risk, kidney and stem cell transplants the lowest. (roche.com)
- 1 , 2 , 3 , 4 , 5 These findings suggest the potential of bone marrow derived stem cells to transdifferentiate into a variety of organ tissues, including those of the eye. (pubmedcentralcanada.ca)
Patients who have undergone1
- Broad-spectrum T cells appear to effectively treat the viral infections that commonly follow an hematopoietic stem cell transplant, researchers reported. (medpagetoday.com)
- In a small clinical trial, infusions of T cells were associated with a 94% response rate when used to treat patients with up to four viral infections, according to Ann Leen, PhD , of the Baylor College of Medicine in Houston, and colleagues. (medpagetoday.com)
- The researchers cautioned that the study was small -- just 11 patients -- and cannot demonstrate definitively that the transplanted cells were responsible for curing the viral infections. (medpagetoday.com)
- Opportunistic viral infections are common in the wake of an hematopoietic stem cell transplant for such diseases as acute lymphoblastic leukemia and non-Hodgkin's lymphoma. (medpagetoday.com)
- The response rate for the 18 infections (involving five different viruses) was high: 94% with 15 complete and two partial responses, the researchers reported, and in all cases, viral clearance was associated with an increase in T cells directed against the infecting pathogen. (medpagetoday.com)
- With multisystemic disease, Langerhans cell histiocytosis must be distinguished from familial hemophagocytic lymphohistiocytosis (FHL) and viral-associated hemophagocytic syndrome. (medscape.com)
- Post-transplant patients normally undergo polymerase chain reaction (PCR) testing for the first three months after the transplant to measure "viral load" - that is, how much CMV is in the body. (roche.com)
- The treatment that immediately precedes infusion of HSC is called conditioning therapy and is given to help kill tumour cells, "wipe out the memory" of the recipient's immune system, and create "space" within the bone marrow for the incoming stem cells to grow. (thedailystar.net)
- Many immunodeficiencies can now be cured by replacing the immune system with a bone marrow transplant. (ncl.ac.uk)
- Furthermore, we may be able to use immune therapy in the autologous setting, perhaps with vaccination strategies or with genetically altered immune cells (ie, chimeric antigen receptors) that target residual cancer. (ascopost.com)
- This therapy reduces the immune system's function to make sure it doesn't reject the organs or stem cells. (roche.com)
- A disease that affects the production of bone marrow cells, such as aplastic anemia , congenital neutropenia , severe immune system illnesses, sickle cell anemia , or thalassemia . (medlineplus.gov)
- Ig is also used for removal of harmful antibodies and for blocking damage from immune cells. (unicare.com)
- Macrophages and dendritic cells are bone marrow derived antigen presenting cells (APC) which serve in the first step of the acquired immune responses. (pubmedcentralcanada.ca)
- Management of TTC7A deficiency currently entails bowel resection for any atresias, possibly hematopoietic stem cell transplantation to correct the immunodeficiencies, and immunosuppression to help alleviate bowel disease and immune disregulation. (wikipedia.org)
- Research indicates that TTC7A deficiency results in "increased Rho kinase activity which disrupts polarity, growth, and differentiation of intestinal epithelial cells, and which impairs immune cell homeostasis, thereby promoting MIA-CID development. (wikipedia.org)
- Underlying disease or indication for transplant, which will help indicate unique risks for the patient as well as potential prognosis for survival. (renalandurologynews.com)
- The median survival after lung transplantation in this group was 24 months. (transplantnow.com)
- Significant survival advantages for the abatacept group were demonstrated at 1-year post-transplant. (ascopost.com)
- As a result, patients receiving the post-transplant regimen with abatacept experienced improved disease-free and overall survival compared to those who did not. (ascopost.com)
- In this cohort, characterized by low comorbidity and a short interval between diagnosis and transplantation, NRM was the most determinant factor for survival after SCT (47 % after 2-year follow-up). (ru.nl)
- A retrospective analysis of 511 patients consecutively transplanted between January 1995 and March 2000 was performed to evaluate survival, cause of death, and PT-Hb. (ashpublications.org)
- Significant survival advantages for the abatacept group were demonstrated at one year post-transplant. (seattlechildrens.org)
- Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice. (springer.com)
- Dr Colin Phipps Diong, Parkway Cancer Centre's new consultant specialising in lymphoma and blood cancers, and haematopoietic stem cell transplantation, explains haematopoietic stem cell transplantation. (thedailystar.net)
- Hematopoietic stem cell transplantation was first used as a treatment for some types of cancer but is now widely used as a therapy for various autoimmune diseases. (medicalnewstoday.com)
- Programmed death 1 ligand (PD-L1) is an immunomodulatory molecule expressed by cancer cells, and it has been widely demonstrated to inhibit host antitumor responses. (springer.com)
- Up to 4.3 years after transplant, HIV DNA was not detected in the blood and rectal tissue among two patients with HIV who underwent hematopoietic stem cell transplantation for cancer, researchers reported at the 2013 International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention in Kuala Lumpur, Malaysia. (healio.com)
- Data from a randomized study in patients with non-small cell lung cancer treated with etoposide (in combination with cisplatin) support the use of etoposide for the treatment of this condition [Arriagada . (drugs.com)
- Additional data from a phase III trial in patients with stage IIIA non-small cell lung cancer with ipsilateral mediastinal nodal metastases also supports the use of etoposide (in combination with cisplatin and radiation therapy) for the treatment of this condition [Albain . (drugs.com)
- Based on American Society of Clinical Oncology Guidelines for Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer , etoposide (in combination with platinum therapy) may be considered for stage IV non-small cell lung cancer patients with large-cell neuroendocrine carcinoma. (drugs.com)
- Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. (globenewswire.com)
- Dr. Hickstein trained in hematology and hematopoietic stem cell transplantation at the University of Washington School of Medicine and the Fred Hutchinson Cancer Research center. (cancer.gov)
- Lung transplantation may be performed for severe refractory BO. (transplantnow.com)
- The authors conclude that lung transplantation is a possible therapeutic option for certain patients with severe therapy-refractory BO. (transplantnow.com)
- Anti-B-cell monoclonal antibody treatment of severe posttransplant B-lymphoproliferative disorder: prognostic factors and long-term outcome. (semanticscholar.org)
- Hematopoietic stem cell transplants are used to treat leukaemias, lymphomas and some non-cancerous disorders like severe immunodeficiencies. (roche.com)
- To assess HSC capability, defrosts from single collections were bead-separated into CD34 + cells and infused into sublethally irradiated nonobese diabetic (NOD)/severe combined immunodeficient (SCID) mice. (pnas.org)
- Although ADAMTS13 activity less than 5% was noted in 60% of patients with acute TTP, it was not found in any patients with hemolytic-uremic syndrome (HUS) or in any patients with transplant-associated TMA. (cancernetwork.com)
- Acute GVHD is a complication that can arise after stem cell transplantation. (ascopost.com)
- At 100 days post-transplant, the cumulative incidence of grade III to IV acute GVHD occurred in 3% of patients receiving abatacept compared to 32% receiving CNI/MTX and 22% receiving +ATG. (ascopost.com)
- DECOPI (DEsobstruction COronaire en Post-Infarctus): a randomized multi-centre trial of occluded artery angioplasty after acute myocardial infarction. (nih.gov)
- Bronchiolitis Obliterans (BO) is an obstructive lung disease that can affect individuals that have undergone a lung or hematopoietic stem cell transplant. (clinicaltrials.gov)
- In the USA and other western nations, respiratory syncytial virus is one of the most commonly encountered respiratory viruses among patients who have been diagnosed with a hematologic malignancy or who have undergone a stem cell transplant. (haematologica.org)
- Funding for this research came, in part, from the National Institutes of Health (R21-NS090066, RO1-DK090058) the Cystinosis Research Foundation the Sanford Stem Cell Clinical Center and the California Institute of Regenerative Medicine. (newswise.com)
- Premature red cell death causes clinical symptoms of hemolytic anemia. (haematologica.org)
- She is also Principal Investigator for the Data and Coordinating Center of the Blood and Marrow Transplant Clinical Trials Network. (ascopost.com)
- GlaxoSmithKline plc (LSE/NYSE: GSK) today announced that new data from a Phase III clinical study supports the safety and efficacy of Shingrix (Zoster Vaccine Recombinant, Adjuvanted) in preventing shingles (herpes zoster) when given to adults 18 years and above shortly after undergoing autologous haematopoietic stem cell transplant (auHSCT). (gsk.com)
- 15 yr, can be efficiently retrieved, and most likely remain effective for clinical transplantation. (pnas.org)
- Design and Methods We performed a retrospective cohort study to measure the incidence and severity of parainfluenza types 1-4, influenza (A and B), respiratory syncitial virus and human rhinovirus disease in myeloablative versus non-myeloablative versus autologous hematopoietic cell transplantation patients. (haematologica.org)
- We performed a retrospective cohort study to measure the incidence and severity of these infections in myeloablative versus non-myeloablative hematopoietic cell transplantation patients. (haematologica.org)
- Solid tumors after hematopoietic stem cell transplantation in Japan: incidence, risk factors and prognosis. (springer.com)
- Hematopoietic stem cell transplantation therapy is potentially curative for many malignant and non-malignant hematopoietic disorders. (clinicaltrials.gov)
- The main indications for transplant were lymphoproliferative disorders (54.5 percent) and leukemias (33.8 percent), and the majority took place in either Europe (48 percent) or the Americas (36 percent). (wikipedia.org)
- Skin lesions of Langerhans cell histiocytosis must be differentiated from other dermatologic disorders, such as diaper rash, seborrheic dermatitis, juvenile xanthogranulomas, xanthoma disseminatum, and various other skin eruptions. (medscape.com)
- Cell therapy has applications in a large number of disorders. (globenewswire.com)
- Stem cell transplants are approved to treat various cancers. (medicalnewstoday.com)
- The aim of the present study was to identify clinicopathological features associated with PD-L1 expression in the secondary solid cancers of patients after allogeneic hematopoietic stem cell transplantation. (springer.com)
- The present results revealed distinct PD-L1 expression in the secondary solid cancers of post-transplant patients with chronic GVHD. (springer.com)
- Solid cancers after allogeneic hematopoietic cell transplantation. (springer.com)
- The term haematopoietic stem cell (HSC) refers to cells made in the blood factory or bone marrow that have the potential to grow into almost any type of blood cell. (thedailystar.net)
- In this procedure, blood is drawn from one arm, which then goes through a machine that filters out stem cells and white blood cells. (thedailystar.net)
- After conditioning therapy, stem cells are infused into the bloodstream (usually between 30 and 60 minutes), akin to a blood transfusion procedure. (thedailystar.net)
- The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood-cell production. (wikipedia.org)
- Bronchiolitis obliterans or bronchiolitis obliterans syndrome is a lung disorder that occurs as a complication of either lung transplantation or bone marrow/blood stem cell transplantation. (clinicaltrials.gov)
- In bronchiolitis obliterans, the body s white blood cells or white blood cells from the transplant attack the lungs, which leads to the destruction of lung tissue, and ultimately, scarring or fibrosis of the lung tissues. (clinicaltrials.gov)
- Researchers are interested in testing whether inhaled cyclosporine therapy could be used as a safe and effective treatment for bronchiolitis obliterans or bronchiolitis obliterans syndrome occurring after bone marrow/blood stem cell or lung transplants. (clinicaltrials.gov)
- Individuals between 10 and 80 years of age who have been diagnosed with bronchiolitis obliterans or bronchiolitis obliterans syndrome after blood or lung transplants. (clinicaltrials.gov)
- Time Frame: Participants will have blood drawn at baseline and on Days 1, 7, 10, 28, and 90 post vaccinations following hematopoietic stem cell transplantation. (clinicaltrials.gov)
- Participants will have blood drawn at baseline to Day 90 post vaccinations following hematopoietic stem cell transplantation. (clinicaltrials.gov)
- The blood is then collected by venipuncture and subjected to leukapheresis to obtain the cells for transplantation. (cmaj.ca)
- Dr. Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells . (citizendium.org)
- We retrospectively reviewed all blood cultures performed in 1453 patients who received HSC transplant at our institution between 1980 and 2002. (nih.gov)
- The blood group remained B (recipient's pre-transplant blood group) on both the forward and reverse grouping. (nature.com)
- This analysis by the Swiss Blood Stem Cell Transplantation Group, based on data from 2008-2011, describes, treatment rates in Switzerland for specific indications and compares this with data from Germany, France, Italy and the Netherlands, corrected for the size of the population. (smw.ch)
- 2 The treatment for PKD is mainly supportive, and consists of regular red blood cell transfusions, splenectomy and chelation therapy for iron overload. (haematologica.org)
- In addition, medical treatments called mobilizations can induce the cells to move from the bone marrow into the blood stream. (regmednet.com)
- HSCs function to initiate and sustain production of the many different mature blood cells, including red blood cells, white blood cells, and platelets, that must be continuously replenished throughout life. (regmednet.com)
- The bone marrow produces blood cells. (medlineplus.gov)
- Stem cells are immature cells in the bone marrow that give rise to all of your different blood cells. (medlineplus.gov)
- Due to the smaller number of stem cells, blood counts take much longer to recover. (medlineplus.gov)
- The stem cells travel through the blood into the bone marrow. (medlineplus.gov)
- and 47,000 red blood cells (RBC)/mm 3 . (ajnr.org)
- Many pre-transplant factors are known to influence the outcome of allogeneic stem cell transplantation (SCT) treatment in myelodysplastic syndromes (MDS). (ru.nl)
- Negative Impact of Pre-Transplant Anemia on Long-Term Outcome after Allogeneic Hematopoietic Stem Cell Transplantation. (ashpublications.org)
- The questionnaire contained questions on disease characteristics, pre-transplant condition, transplant regimen and post-transplant outcome. (haematologica.org)
- The primary outcome is the fraction of patients who maintain any form of anti-retroviral therapy, including enfuvirtide monotherapy, through day 60 post-transplant. (knowcancer.com)