Bone Transplantation: The grafting of bone from a donor site to a recipient site.Bone Banks: Centers for acquiring, characterizing, and storing bones or bone tissue for future use.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Kidney Transplantation: The transference of a kidney from one human or animal to another.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Heart Transplantation: The transference of a heart from one human or animal to another.Hematopoiesis: The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Transplantation Chimera: An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Hematopoietic Stem Cell Mobilization: The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Cell Lineage: The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Bone Resorption: Bone loss due to osteoclastic activity.Cord Blood Stem Cell Transplantation: Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Cell Transplantation: Transference of cells within an individual, between individuals of the same species, or between individuals of different species.Transplantation Immunology: A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.Mice, Inbred C57BLTransplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Islets of Langerhans Transplantation: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.Hematologic Neoplasms: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.Stem Cell Niche: A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.Colony-Forming Units Assay: A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.Transplantation, Isogeneic: Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Whole-Body Irradiation: Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.Peripheral Blood Stem Cell Transplantation: Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.Bone Development: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Mesenchymal Stem Cell Transplantation: Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).Histocompatibility Testing: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)Fetal Blood: Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Adult Stem Cells: Cells with high proliferative and self renewal capacities derived from adults.Bone Diseases: Diseases of BONES.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Neoplastic Stem Cells: Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.Transplantation, Heterologous: Transplantation between animals of different species.Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)Histocompatibility: The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.Cell SeparationCell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Transplantation, Heterotopic: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.Plant Stems: Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Hematopoietic System: The blood-making organs and tissues, principally the bone marrow and lymph nodes.Multipotent Stem Cells: Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)Transplantation Tolerance: An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.Fetal Tissue Transplantation: Transference of fetal tissue between individuals of the same species or between individuals of different species.Recurrence: The return of a sign, symptom, or disease after a remission.Heart-Lung Transplantation: The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.Mice, SCID: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.Stem Cell Factor: A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.Immunosuppression: Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.Busulfan: An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Chimerism: The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.Mice, Inbred NOD: A strain of non-obese diabetic mice developed in Japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent diabetes mellitus in which insulitis is a major histopathologic feature, and in which genetic susceptibility is strongly MHC-linked.Mesonephros: One of a pair of excretory organs (mesonephroi) which grows caudally to the first pair (PRONEPHROI) during development. Mesonephroi are the permanent kidneys in adult amphibians and fish. In higher vertebrates, proneprhoi and most of mesonephroi degenerate with the appearance of metanephroi. The remaining ducts become WOLFFIAN DUCTS.Pluripotent Stem Cells: Cells that can give rise to cells of the three different GERM LAYERS.Bone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Radiation Chimera: An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.Fetal Stem Cells: Cells derived from a FETUS that retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.Lentivirus: A genus of the family RETROVIRIDAE consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region. Five serogroups are recognized, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species.Transduction, Genetic: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Myeloablative Agonists: Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Neural Stem Cells: Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.Hematologic Diseases: Disorders of the blood and blood forming tissues.Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Donor Selection: The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.Proto-Oncogene Proteins c-kit: A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).Lymphopoiesis: Formation of LYMPHOCYTES and PLASMA CELLS from the lymphoid stem cells which develop from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW. These lymphoid stem cells differentiate into T-LYMPHOCYTES; B-LYMPHOCYTES; PLASMA CELLS; or NK-cells (KILLER CELLS, NATURAL) depending on the organ or tissues (LYMPHOID TISSUE) to which they migrate.Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Myeloid Progenitor Cells: Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS.Retroviridae: Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.Induced Pluripotent Stem Cells: Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.Graft vs Leukemia Effect: Immunological rejection of leukemia cells following bone marrow transplantation.Waiting Lists: Prospective patient listings for appointments or treatments.Bone Diseases, MetabolicBone Morphogenetic Proteins: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Severe Combined Immunodeficiency: Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).Bone Substitutes: Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.Hematopoiesis, Extramedullary: The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.
hematopoietic system G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into the ... "G-CSF-primed bone marrow as a source of stem cells for allografting: revisiting the concept". Bone Marrow Transplantation. 50 ( ... G-CSF may also be given to the receiver in hematopoietic stem cell transplantation, to compensate for conditioning regimens. ... Tay J, Levesque JP, Winkler IG (December 2016). "Cellular players of hematopoietic stem cell mobilization in the bone marrow ...
Ernest McCulloch Connie Eaves Stem Cells Hematopoiesis Hematopoietic stem cells Cellular therapy Bone marrow transplantation ... Cashman J, Dykstra B, Clark-Lewis I, Eaves A & Eaves C. Changes in the proliferative activity of human hematopoietic stem cells ... Clonal hematopoiesis demonstrated by X-linked DNA polymorphisms after allogeneic bone marrow transplantation. N Engl J Med 320 ... Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow ...
Indeed, at least four patients have died in the course of either preparation for or institution of bone marrow transplantation ... "Outcome of 27 patients with Hurler's syndrome transplanted from either related or unrelated haematopoietic stem cell sources". ... However, the severe immunosuppression that bone marrow transplantation requires causes a significant risk of serious infections ... Bone Marrow Transplantation. 31 (12): 1704105. doi:10.1038/sj.bmt.1704105. Fine, Jo-David; Manes, Becky; Frangoul, Haydar (July ...
This patient achieved a complete hematological response and was then given a hematopoietic stem cell transplantation. The ... The disease is aggressive and therefore has been treated aggressively with chemotherapy followed by bone marrow transplantation ... One patient relapsed after 18 months ruxolitinib therapy and required Hematopoietic stem cell transplantation (HSCT). The ... FLT3 inhibitor followed by hematopoietic stem cell transplantation, may be the best approach currently available for treating ...
For a long time, the most efficient approach had been to use bone marrow graft, or hematopoietic stem cell transplantation. ... Because of all these reasons, bone marrow grafts or hematopoietic stem cell transplantation have seen a decrease in their ... long term follow-up on patients undergone to hematopoietic stem cell transplantation, Minerva Pediatr. 2013 Oct;65(5):487-96. ... The bones themselves may be affected, resulting in short stature. In addition, pebbly, ivory-colored skin lesions may be found ...
"Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation". Bone Marrow ... Hollenbeck ST, Sakakibara K, Faries PL, Workhu B, Liu B, Kent KC (August 2004). "Stem cell factor and c-kit are expressed by ... Hiraoka A, Yano Ki K, Kagami N, Takeshige K, Mio H, Anazawa H, Sugimoto S (2002). "Stem cell growth factor: in situ ... Lee E, Min HK, Oskeritzian CA, Kambe N, Schwartz LB, Wook Chang H (November 2003). "Recombinant human (rh) stem cell factor and ...
... of hematopoietic stem cells in the blood before collection by leukapheresis for use in hematopoietic stem cell transplantation ... Increased hematopoietic activity of the bone marrow in response to growth factor therapy has been associated with transient ... Causes of neutropenia include chemotherapy and bone marrow transplantation. Filgrastim is also used to increase the number ... patients with cancer undergoing bone marrow transplantation; patients undergoing autologous peripheral blood progenitor cell ...
... randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation". Bone Marrow ... randomized clinical trial in patients undergoing bone marrow transplantation. This trial demonstrated that Caphosol, used in ... were evaluated in 95 patients undergoing bone marrow transplantation. The treatment arm received 4 topical fluoride treatments ... The results showed: More than twice as many bone marrow transplant patients avoided oral mucositis by using Caphosol Duration ...
... are used to quantify and purify hematopoietic progenitor stem cells for research and for clinical bone marrow transplantation. ... It is important to mention that Long-Term Hematopoietic Stem Cells (LT-HSCs) in mice and humans are the hematopoietic cells ... are normally found in the umbilical cord and bone marrow as hematopoietic cells, or in mesenchymal stem cells, endothelial ... Injection of CD34+ hematopoietic Stem Cells has been clinically applied to treat various diseases including Spinal Cord Injury ...
Hematopoietic Stem Cell Transplantation (HSCT) involves intravenous infusion of stem cells to those who have either a damaged ... Transplantation of stem cells are taken from the bone marrow, peripheral blood or umbilical cord of healthy, matched donors. ... Hematopoietic stem cells give rise to blood cells. Differentiation and proliferation of hematopoietic stem cells require a lot ... "Hematopoietic Stem Cell Transplantation". Medscape. "Severe combined immunodeficiency (SCID)". Retrieved 2016-11-20. ...
The number of pregnancies observed after hematopoietic stem cell transplantation involving such as procedure is lower than 2%. ... is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) ... Tichelli André, Rovó Alicia (2013). "Fertility Issues Following Hematopoietic Stem Cell Transplantation". Expert Rev Hematol. 6 ... Non-myeloablative bone marrow transplantation uses lower doses of total body irradiation, typically about 2 Gy, which do not ...
Differential admixture and its potential impact on hematopoietic stem cell transplantation". Bone Marrow Research. 2012: 136087 ... Another study shows an increased risk of graft-versus-host disease complications after transplantation due to genetic variants ... "Copy number variation may stem from replication misstep". EurekAlert!. 27 December 2007. Retrieved 2011-09-05. Lee, JA; ...
McCulloch, E.A. (2003) Normal and leukaemic hematopoietic stem cells and lineages. In: Stem Cells Handbook, Ed. Stewart Sell, ... Visible nodules were observed in the spleens of the mice, in proportion to the number of bone marrow cells injected. Till and ... determined by quantitative marrow transplantation into irradiated mice. Radiation Research 13(1):115-125. [Link to article] ... McCulloch's work revolutionised cell biology and cancer therapy with the discovery of stem cells in the hematopoietic system. ...
At the Bone Marrow Transplantation Unit of the University Hospital of Patras, a fully accredited Allogeneic Hematopoietic Stem ... In Greece, Hematopoietic Cell Transplantation (HCT) was first performed in 1985 and over 250 are now carried out every year. ... The 4 major units that perform Allogeneic - stem cells harvested from genetically similar but not identical donors - and ... Autologous - stem cells harvested from self- HCTs are found at the "EVANGELISMOS" Hospital in Athens, the "PAPANIKOLAOU" ...
PMID 11177610 A. Spyridonidis, R. Mertelsmann, J. Finke: Hematopoietic stem cell transplantation: more than just hematopoietic ... h.c. Roland Mertelsmann R. Mertelsmann: Plasticity of bone marrow-derived stem cells. In: J Hematother Stem Cell Res. 2000 Dec; ... An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. In: Bone Marrow ... The "Plasticity" of hematopoietic stem cells (HSC), i.e. the differentiation of HSC into cells of other organs, was intensively ...
Allogeneic hematopoietic stem cell transplantation ("bone marrow transplantation" from a genetically non-identical donor) can ... For this reason, bone marrow, or peripheral blood stem cell harvesting is carried out before the ablative part of the therapy, ... This is known as autologous stem cell transplantation. Targeted therapy, which first became available in the late 1990s, has ... For this reason, allogeneic HSCT leads to a higher cure rate than autologous transplantation for several cancer types, although ...
England Bone Marrow Transplantation, Hematopoietic stem cell transplantation 5-hydroxyfuranocoumarin 5-O-methyltransferase, an ...
2004).Effective treatment of alpha-mannosidosis by allogeneic hematopoietic stem cell transplantation. J Pediatr, 144:569-573. ... 1987). "Bone marrow transplantation in the treatment of alpha-mannosidosis". Disease in Childhood. 62 (10): 1044-1049. doi: ... Hematopoietic stem cell transplantation (HSCT) can be a treatment option for some patients, however the risk-benefit profile is ... The long-term forecast for the condition is poor. There is generally a slow progression of neuromuscular and bone changes ...
"The US National Marrow Donor Program role in unrelated donor hematopoietic cell transplantation". Bone Marrow Transplantation. ... Peripheral Blood Stem Cells (PBSC): It is possible to collect stem cells from the peripheral blood rather than the bone ... This mobilizes stem cells to travel from the bone marrow into the circulating blood. The stem cells are collected through a ... The Gift of Life Marrow Registry is a public bone marrow and blood stem cell registry headquartered in Boca Raton, Florida. ...
From 1993-1999, Gale was Senior Physician and Corporate Director of Bone Marrow and Blood Cell Transplantation at Salick Health ... He has worked on alternate sources of hematopoietic stem cells including fetal liver transplants. Gale has published over 1000 ... His activities include development and execution of clinical trials in blood and bone marrow cancers, transplantation and ... Gale has contributed to basic science and clinical research in bone marrow transplantation where he made contributions to ...
Gaziev, J; Lucarelli, G (June 2011). "Hematopoietic stem cell transplantation for thalassemia". Current Stem Cell Research & ... Bone deformities: Thalassemia can make the bone marrow expand, which causes bones to widen. This can result in abnormal bone ... Bone marrow expansion also makes bones thin and brittle, increasing the risk of broken bones. Enlarged spleen: The spleen aids ... "Hematopoietic stem cell transplantation for people with ß-thalassaemia major". The Cochrane Database of Systematic Reviews. 11 ...
June 2011). "Successful allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia during respiratory ... Bone Marrow Transplantation. 47 (1): 46-53. doi:10.1038/bmt.2011.15. PMID 21358688. Zohren F, Czibere A, Bruns I, et al. ( ... high-dose cytarabine and 12 Gy total body irradiation followed by allogeneic hematopoietic stem cell transplantation is ... and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients ...
... is used the same way that hematopoietic stem cell transplantation is used to reconstitute bone marrow following ... hematopoietic cell transplantation stem cell transplantation (4th ed.). Oxford: Wiley-Blackwell. ISBN 9781444303537. Haller M J ... Adverse effects are similar to hematopoietic stem cell transplantation, namely graft-versus-host disease if the cord blood is ... 9 November 2016). "Milestones of Hematopoietic Stem Cell Transplantation - From First Human Studies to Current Developments". ...
"Young woman with mild bone marrow dysplasia, GATA2 and ASXL1 mutation treated with allogeneic hematopoietic stem cell ... transplantation". Leuk Res Rep. 4 (2): 72-5. doi:10.1016/j.lrr.2015.10.001. Kumar MS, Hancock DC, Molina-Arcas M, Steckel M, ... Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH (1994). "An early haematopoietic defect in mice ... Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH (September 1994). "An early haematopoietic defect in ...
City of Hope performed its 10,000th hematopoietic stem cell transplantation, which includes transplants of bone marrow, ... peripheral blood stem cells collected by apheresis, and umbilical cord stem cells. By 2016, this has grown to over 13,000 stem ... The center has performed 13,000 hematopoietic stem cell transplants as of 2016 with patient outcomes that consistently exceed ... National Bone Marrow Transplantation Research Network (founding member) National Gene Vector Laboratory Southern California ...
... activity associates with acute B lymphoblastic leukemia relapse after allogeneic hematopoietic stem cell transplantation. ... bone marrow transplantation, and HIV-1 infection. Annual Review of Immunology. 2000, 18: 529-560. ISSN 0732-0582. PMID 10837068 ... T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation. Blood Cancer ... American Journal of Transplantation. September 2015, 15 (9): 2431-42. PMID 25943855. doi:10.1111/ajt.13288.. ...
... Complications of Bone Marrow or Hematopoietic Stem Cell ... Complications of Bone Marrow Transplantation. Complications of Bone Marrow or Hematopoietic stem cell transplantation include ... Complications of bone marrow transplantation/ hematopoietic stem cell transplantation include:. Complications due to ... Animation and slides providing graphic explanation of Bone Marrow Transplantation (BMT)/Stem Cell Transplantation that is done ...
Allogeneic hematopoietic stem cell transplantation (HSCT) is a standard therapeutic intervention for hematological malignancies ... CRISPR/Cas9-modified hematopoietic stem cells-present and future perspectives for stem cell transplantation. Bone Marrow ... CRISPR/Cas9-modified hematopoietic stem cells-present and future perspectives for stem cell transplantation. *Alberto Daniel- ... Allogeneic hematopoietic stem cell transplantation (HSCT) is a standard therapeutic intervention for hematological malignancies ...
Physical Complications After Bone Marrow Transplantation. Survivors of hematopoietic stem cell transplantation (HSCT) in ... Secondary Malignancies After Hematopoietic Stem Cell Transplantation. *Physical Complications After Bone Marrow Transplantation ... Secondary Malignancies After Hematopoietic Stem Cell Transplantation. *Physical Complications After Bone Marrow Transplantation ... Psychosocial and Cognitive Complications of Bone Marrow Transplantation. Children receiving hematopoietic stem cell ...
Hematopoietic Stem Cell Transplantation/Bone Marrow Transplantation (October 2013) - Subscription required ... Hematopoietic Stem Cell Transplantation/Bone Marrow Transplantation (October 2013). previous. index. next. ...
... germline FANCC/FANCG deficient mice enable efficient and durable engraftment of hematopoietic stem cells after transplantation ... Bone marrow niches of germline FANCC/FANCG deficient mice enable efficient and durable engraftment of hematopoietic stem cells ... Bone marrow niches of germline FANCC/FANCG deficient mice enable efficient and durable engraftment of hematopoietic stem cells ... 1Comprehensive Bone Marrow Failure Center, Childrens Hospital of Philadelphia, Philadelphia. *. 2Blood and Marrow Transplant ...
Mesenchymal stem cells (MSCs) have been shown to support hematopoiesis in vivo and to display potent immunosuppressive effects ... Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for severe aplastic anemia (SAA) is mainly limited by the ... Cotransplantation of bone marrow-derived mesenchymal stem cells in haploidentical hematopoietic stem cell transplantation in ... Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for severe aplastic anemia (SAA) is mainly limited by the ...
Hematopoietic stem cell transplantation (HSCT) using an optimized conditioning regimen is essential for the long-term survival ... Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes. Bone Marrow Transplant ... Disease-specific hematopoietic stem cell transplantation in children with inherited bone marrow failure syndromes. Zeitschrift: ... Disease-specific hematopoietic stem cell transplantation in children with inherited bone marrow failure syndromes ...
Haematopoietic stem cell transplantation. To characterise bone marrow derived stem cells in the mouse sclera, we examined HSC ... Schematic diagram of bone marrow (BM) and haematopoietic stem cell (HSC) transplantation (A) and representative images of BM (B ... resident and inflammatory bone marrow derived cells in the sclera by bone marrow and haematopoietic stem cell transplantation. ... Bone marrow transplantation. To investigate the participation of bone marrow cells in the sclera, we performed bone marrow ...
Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation): How CPT Codes Are Reported (June 2009) - Subscription ... Hematopoietic Cell Transplantation (Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation): How CPT Codes Are ... June 2009 pages 3-6 Hematopoietic Cell Transplantation (Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation): ... www.findacode.com/newsletters/ama-cpt-assistant/hematopoietic-cell-transplantation-hematopoietic-stem-6.html. Copyright © 2000- ...
Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT) 5 ...
Pulmonary cytolytic thrombi after allogeneic hematopoietic cell transplantation: a further histologic description. Biology of ... blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2005 Jun;11;484-5 2005 ... Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT) 5 ...
... score is a risk score for mortality after allogeneic hematopoietic SCT (HSCT). Ethnicity is a genetically determined factor ... Bone Marrow Transplantation (2019) * THE FUTURE OF HEMATOPOIETIC STEM CELL TRANSPLANTATION *Takanori Teshima ... Patient eligibility for hematopoietic stem cell transplantation: a review of patient-associated variables *J. Tay ... Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study. Blood 2010 ...
Treating Leukemia With Stem Cells Biotechology UPH sonianto kuddi 2009 nanotechnology. Indonesia ... Treating Leukemia With Stem Cells - Free download as Powerpoint Presentation (.ppt) or view presentation slides online. ... The best-characterized adult stem cells are. hematopoietic stem cells that reside in the. bone marrow.. Aim. To know how to ... bone marrow, while. peripheral blood stem cell. transplantation is a method. of replacing blood-forming. cells destroyed by ...
Schematic of electroporation-based autologous transplant protocol. Primed bone marrow (BM) aspirates were collected from 4 ... or from total leukocytes collected from each animal 6 to 12 and 189 to 198 days following transplantation of these cells. CCR5 ... Genome editing in hematopoietic stem and progenitor cells (HSPCs) is a promising novel technology for the treatment of many ... Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates.. Peterson CW1, ...
bone marrow transplantation. thalassemia. CGD. HLH. Blackfan-Diamond anemia. Hurler. leukodystrophy. LAD I. Red blood cell ... Procedure: Hematopoietic stem cell transplantation hematopoietic stem cell transplantation conditioning regimen depending on ... Procedure: Hematopoietic stem cell transplantation hematopoietic stem cell transplantation conditioning regimen depending on ... Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells. This study has been completed. ...
A process is also provided for enriching and recovering human hematopoietic progenitor cells and stem cells in a sample ... containing human hematopoietic differentiated, progenitor, and stem cells, and optionally tumor cells. The process involves ... conjugates are removed and a cell preparation is obtained which is enriched in human hematopoietic progenitor cells and stem ... and/or antibodies specific for antigen expressed on non-hematopoietic tumor cells under conditions so that cell conjugates are ...
The Potential of Gene Transfer into Hematopoietic Vectors with the potential for stable transgene integration are Cells widely ... Gene Transfer into Hematopoietic Cells: From Basic Science to Clinical Application Christopher Baum 1. ... Leukemia Diagnosis in Murine Bone Marrow Transplantation Models. Pages 311-329. Li, Zhixiong (et al.) ... Genetic Modification of Hematopoietic Stem Cells. Book Subtitle. Methods and Protocols. Editors. * Christopher Baum ...
Co-transplantation of MSCs and hematopoietic stem cells (HSCs) promotes successful engraftment and improves... ... Mesenchymal stem cells (MSCs) are a promising candidate for cellular therapies. ... Mesenchymal stem cell Bone marrow transplantation CXCR4 Wei Chen, Miao Li, and Guizhen Su have contributed equally to this work ... Co-transplantation of Hematopoietic Stem Cells and Cxcr4 Gene-Transduced Mesenchymal Stem Cells Promotes Hematopoiesis. ...
bone marrow transplantation. reduced intensity conditioning. Adrenoleukodystrophy. Metachromatic Leukodystrophy. Globoid Cell ... Biological: Hematopoietic stem cell transplantation Patients will be transplanted using either a related or unrelated allograft ... Hematopoietic stem cell transplantation will be infused on Day 0. Post-transplant immunosuppression to follow: Mycophenolate ... Hematopoietic stem cell transplantation Drug: Cyclosporine A Drug: Mycophenolate mofetil ...
Bone marrow stem cell therapy is offered by Dr. Kevin Kaplan in Jacksonville, FL. ... Bone marrow is usually aspirated from your hip region. ... Stem Cell Therapy *Types of Stem Cells. *Use of Stem Cells in ... The procedure begins with your doctor extracting stem cells from your own bone marrow. Bone marrow is usually aspirated from ... A needle is then introduced into an area of your pelvic bone known as the iliac crest. Bone marrow is then aspirated using a ...
This study aimed to explore global DNA methylation dynamic of bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) ... Functional analysis of promoter methylation changes identified genes involved in hematopoietic cell activation, differentiation ... play a role in the reconstitution of the hematopoietic system after AHSCT. ... Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative therapeutic approach for different hematological ...
BONE MARROW) TRANSPLANTATION? The term haematopoietic stem cell (HSC) refers to cells made in the blood factory or bone marrow ... Transplantation of HSC (HSCT) is done in order to re-establish bone marrow and immune system function after being damaged and/ ... WHAT IS HAEMATOPOIETIC (BONE MARROW) TRANSPLANTATION?. The term haematopoietic stem cell (HSC) refers to cells made in the ... and haematopoietic stem cell transplantation, explains haematopoietic stem cell transplantation.. ...
... intracoronary transplantation of autologous bone marrow stem cells; mobilization of bone marrow stem-cells induced by G-CSF; ... For many decades, bone marrow (BM) transplantation was the only viable method for transplanting hematopoietic stem cells, ... A. Gratwohl, H. Baldomero, O. Schmid et al., "Change in stem cell source for hematopoietic stem cell transplantation (HSCT) in ... cell count predicts the likelihood of successful hematopoietic stem cell mobilization," Bone Marrow Transplantation, vol. 38, ...
Inherited bone marrow failure (IBMF) syndromes are a heterogeneous group of rare hematological disorders characterized by the ... In these congenital disorders, hematopoietic stem cell transplantation (HSCT) is often a consideration. However, HSCT will not ... Inherited bone marrow failure (IBMF) syndromes are a heterogeneous group of rare hematological disorders characterized by the ... Indications as well as transplantation characteristics are most of the time controversial in this setting because of the rarity ...
... associate director and clinical professor at City of Hopes Hematologic Malignancies and Stem Cell Transplantation Institute. ... 1988 -1989, Fellowship in medical oncology/bone marrow transplantation, City of Hope, Duarte, CA ... dose of a patients own healthy stem cells within a relatively short period of time. ... 2003 - present, Staff Physician and Clinical Professor, Department of Hematology & Hematopoietic Cell Transplantation, City of ...
CellsChemotherapyProgenitorDonorTransplantsGVHDInherited bone marrowBlood and marrowRecipientsPeripheral blood stem cell transplantHaploidenticalProcedureDepartment of HematologyProgenitorsComplicationsAplasticUndergoHematologic MalignanciesCord Blood TransplantationMyelodysplastic SyndromeDonorsAdultMalignantTherapiesSystemicMarrow-derived
- Myelodysplastic syndrome (MDS) is a clonal bone marrow disorder characterized by ineffective hematopoiesis such that the bone marrow doesn't produce enough healthy blood cells , instead making too many immature cells or "blasts" (megakaryoblasts, proerythroblasts, myeloblasts, and lymphoblasts). (shu.edu)
- These changes alter normal hematopoietic growth and differentiation, resulting in an accumulation of abnormal, immature myeloid cells in the bone marrow and the impairment of normal hematopoiesis. (shu.edu)
- Genome editing in hematopoietic stem and progenitor cells (HSPCs) is a promising novel technology for the treatment of many human diseases. (nih.gov)
- A process is also provided for enriching and recovering human hematopoietic progenitor cells and stem cells in a sample containing human hematopoietic differentiated, progenitor, and stem cells, and optionally tumor cells. (google.com)
- The cell conjugates are removed and a cell preparation is obtained which is enriched in human hematopoietic progenitor cells and stem cells. (google.com)
- c) recovering a cell preparation which is enriched in human hematopoietic progenitor cells and human hematopoietic stem cells, wherein the cell preparation recovered in step (c) has about a 3 to 5 log depletion of tumor cells and differentiated cells and is not labeled or coated with antibodies. (google.com)
- The identification of new mechanisms that regulate the trafficking of hematopoietic stem/progenitor cells (HSPCs) cells has important implications, not only for hematopoietic transplantation but also for cell therapies in regenerative medicine for patients with acute myocardial infarction, spinal cord injury, and stroke, among others. (hindawi.com)
- and (d) the effects of this mobilization on BM-derived stem/progenitor cells in clinical trials of patients with different diseases. (hindawi.com)
- The successful transplantation of hematopoietic stem/progenitor cells (HSPCs) is based on their ability to home to the BM niche and on their engraftment capacity. (hindawi.com)
- Although BM and peripheral blood are both still considered a source of stem/progenitor cells for this purpose [ 8 , 9 ], peripheral blood is used in 71% of allogeneic transplantations [ 6 ]. (hindawi.com)
- Abnormal immunity and stem/progenitor cells in acquired aplastic anemia. (springer.com)
- In a conditional-knockout mouse model, we show that Cdc42 −/− HSCs enter the active cell cycle, resulting in significantly increased number and frequency of the stem/progenitor cells in the BM. (pnas.org)
- Previously, in a gain-of-Cdc42 activity, Cdc42GAP −/− mouse model, we have found that constitutively increased Cdc42-GTP species cause increased hematopoietic progenitor apoptosis, disorganized actin structure, and defective engraftment without affecting the cell cycle status ( 13 ). (pnas.org)
- Success with transplantation of autologous hematopoietic stem and progenitor cells (HSPCs) in patients depends on adequate collection of these cells after mobilization from the bone marrow niche by the cytokine granulocyte colony-stimulating factor (G-CSF). (sciencemag.org)
- Transplantation of hematopoietic stem and progenitor cells (HSPCs) is a well-established therapy for treating benign and malignant blood diseases ( 1 , 2 ). (sciencemag.org)
- Since reduced marrow cellularity and prolonged pancytopenia following autologous bone marrow transplantation (ABMT) have been frequently observed in patients with acute myelogenous leukemia (AML) included in the AML10 GIMEMA/EORTC trial, the question was raised to what extent hematopoietic and microenvironmental progenitor cells were involved in these patients. (semanticscholar.org)
- Natural gas in spanish More recently, the survey has included additional information on novel cell therapies with hematopoietic stem cells for non-hematopoietic use, as well as on the use of non-hematopoietic stem and progenitor cells. (gaselectricity.in)
- For umbilical cord transplantation, see TRANS.00016 Umbilical Cord Blood Progenitor Cell Collection, Storage and Transplantation for additional information and criteria. (unicare.com)
- Their previous studies, as well as those of other investigators, suggest that, in the appropriate context, Notch signaling delays differentiation and promotes expansion of hematopoietic stem/progenitor cells. (rochester.edu)
- In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly correct genetic disorders of bone, cartilage and muscle, but clinical support for this concept is lacking. (nih.gov)
- Thus, allogeneic bone marrow transplantation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility of this strategy in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well. (nih.gov)
- Using these mice, we find that Evi1 is predominantly expressed in long-term HSCs (LT-HSCs) in adult bone marrow, and in the hematopoietic stem/progenitor fraction in the aorta-gonad-mesonephros, placenta, and fetal liver of embryos. (rupress.org)
- We and others have reported that Evi1 accomplishes an important regulatory function in hematopoietic stem/progenitor cells (HSPCs) during fetal and adult development. (rupress.org)
- It is a marker that is frequently found on multipotent progenitor cells, including immature hematopoietic stem and progenitor cells. (miltenyibiotec.com)
- Hematopoietic stem and progenitor cell (HSPC) functions are governed by intricate signaling networks. (jci.org)
- Recombinant rat stem cell factor synergizes with recombinant human granulocyte colony‐stimulating factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potential. (currentprotocols.com)
- Mobilization of early hematopoietic progenitor cells with BB‐10010: A genetically engineered variant of human macrophage inflammatory protein‐1 alpha. (currentprotocols.com)
- However, their roles in hematopoiesis and hematopoietic stem and progenitor cell (HSPC) functions are not well characterized. (420magazine.com)
- Nonhuman primates have similar stem and progenitor cell dynamics to humans and have been invaluable in developing and assessing new therapeutic transplant approaches for the treatment of human diseases [ 15 - 17 ]. (omicsonline.org)
- The characterization of rare cells in limited volumes of physiological fluids is shown by the isolation and quantitative proteomic profiling of first MCF-7 cells spiked into whole blood as a model system and then two CD133+ endothelial progenitor and hematopoietic cells in whole blood from volunteers. (mcponline.org)
- Graft-versus-host disease occurs due to a reaction between the white blood cells of the donor bone marrow and the recipient s cells. (medindia.net)
- 40/41) achieved hematopoietic reconstitution and sustained full donor chimerism. (ovid.com)
- Kekre N, Antin JH (2014) Hematopoietic stem cell transplantation donor sources in the 21st century: choosing the ideal donor when a perfect match does not exist. (springermedizin.de)
- June 2009 pages 3-6 Hematopoietic Cell Transplantation (Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation): How CPT Codes Are Reported This article describes the hematopoietic cell transplantation (HCT) process and identifies the appropriate CPT codes to use at each step along the way, including identifying a suitable donor, pretransplant patient conditioning, harvesting and infusing the graft, and posttransplant care. (findacode.com)
- This is a clinical trial of bone marrow transplantation for patients with the diagnosis of a genetic disease of blood cells that do not have an HLA-matched sibling donor. (clinicaltrials.gov)
- The blood stem cells will be derived from either unrelated donor or unrelated umbilical cord blood. (clinicaltrials.gov)
- The stem cells will be derived from a 1) matched unrelated donor (MUD) or 2) unrelated umbilical cord blood (UCB). (clinicaltrials.gov)
- In the case of transplants using HSC derived from other people, the conditioning therapy also helps reduce the risk of the recipient's body killing or rejecting the incoming donor stem cells (graft rejection). (thedailystar.net)
- Peinemann F, Grouven U, Kröger N, Pittler M, Zschorlich B, Lange S. Unrelated donor stem cell transplantation in acquired severe aplastic anemia: a systematic review. (springer.com)
- It may take about a month for the donor stem cells in the bone marrow to begin to function fully. (lahey.org)
- This is to prevent your body from rejecting the donor stem cells. (lahey.org)
- The intensive conditioning regimens used to allow for donor hematopoietic stem cell (HSC) engraftment are often associated with severe toxicity, delayed immune reconstitution, life-threatening infections, and thus higher relapse rates. (hindawi.com)
- The highest donor engraftment rate is obtained in autologous HCT when the patient's hematopoietic stem cells (HSCs) are previously collected and successively reinfused after the conditioning regimen. (hindawi.com)
- Myeloablative conditioning regimens that can include total body irradiation or high dose chemotherapy eliminate most of the host immune system allowing for donor stem cell engraftment in several preclinical models and clinical studies [ 4 - 8 ]. (hindawi.com)
- The infusion of a "megadose" of stem cells from the donor and their "veto" effect coupled with depletion of residual radio- and chemoresistant host T cells in vivo allowed for successful HSC engraftment even in these challenging clinical situations [ 11 - 14 ]. (hindawi.com)
- Moreover, children with nonmalignant diseases that require HCT need to be treated with the minimal toxic conditioning regimen that allows for donor stem cell engraftment. (hindawi.com)
- We hypothesized that patients with positive BK viruria before unrelated or mismatched related donor allogeneic hematopoietic stem cell transplantation have a higher incidence of hemorrhagic cystitis. (haematologica.org)
- Paired donor exchange kidney transplantation is a process in which unrelated kidney donors are matched to recipients so that compatible transplants can be performed. (medindia.net)
- Transplantation of material from a donor to another person. (thefreedictionary.com)
- Determine the potential of T-cell-depleted bone marrow and peripheral blood stem cells (PBSC) from HLA-haplotype, partially matched related donors to induce extended disease-free survival in patients with leukemia, lymphoblastic lymphoma, myelodysplastic syndrome, or severe aplastic anemia who would otherwise be ineligible for transplantation because of the lack of an HLA-identical related or unrelated donor. (clinicaltrials.gov)
- Determine the impact of filgrastim (G-CSF)-stimulated, CD34+, E-rosette and T-cell-depleted PBSC derived from an HLA-haplotype, partially matched donor on the incidence and quality of engraftment, kinetics, and quality of hematopoietic and immunologic reconstitution, and incidence and severity of graft-versus-host disease (GVHD) in these patients. (clinicaltrials.gov)
- Allogeneic donor blood and bone marrow transplantation can treat a range of malignant and non-malignant diseases. (mja.com.au)
- For this type of treatment, bone marrow is collected from a donor. (medlineplus.gov)
- Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
- Then, a counselor meets with the donor to discuss the bone marrow donation process. (medlineplus.gov)
- Donor stem cells can be collected in two ways. (medlineplus.gov)
- Most donor stem cells are collected through a process called leukapheresis. (medlineplus.gov)
- First, the donor is given 5 days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
- After a bone marrow harvest, the donor stays in the hospital until they're fully awake and can eat and drink. (medlineplus.gov)
- An image depicting bone marrow donor typing procedures can be seen below. (medscape.com)
- The eligibility criteria for a stem cell donor are essentially the same as for blood donation. (medscape.com)
- Most bone marrow donor procedures are performed under general anesthesia. (medscape.com)
- It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). (wikipedia.org)
- In 2014, according to the World Marrow Donor Association (WMDA), stem cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone marrow donations, 12,506 peripheral blood stem cell donations, and 3,949 cord blood units). (wikipedia.org)
- Studies have reported a wide range of costs for HCT, from $36 000 to $88 000 (USD) for a single autologous transplantation for the initial hospitalization, to $200 000 (USD) or more for a myeloablative allogeneic procedure involving an unrelated donor. (bloodjournal.org)
- Three months after osteoblast engraftment (1.5-2.0% donor cells), representative specimens of trabecular bone showed histologic changes indicative of new dense bone formation. (nih.gov)
- Patients under 50 years with an HLA matched donor undergo allogeneic bone marrow transplantation (BMT). (knowcancer.com)
- Patients under 50 years with no HLA matched donor or patients 50-65 years old undergo autologous bone marrow or peripheral blood stem cell (PBSC) transplantation. (knowcancer.com)
- Collecting stem cells provides a bigger graft, and does not require that the donor be subjected to general anesthesia to collect the graft. (bionity.com)
- Donor selection To avoid rejection of the transplanted stem cells or severe graft-versus-host disease , the donor should have the same human leukocyte antigens (HLA) as the recipient. (bionity.com)
- Other Name: Medrol Biological: Hematopoietic stem cell transplantation Infused on Day 0 - Donor bone marrow or umbilical cord blood will be collected in the usual sterile manner using established parameters determined by the National Marrow Donor Program. (aamds.org)
- Transplantation with matched related bone marrow (BM) or peripheral blood (PB) (stem) cells is considered the standard for allo-HCT, but also matched unrelated donors (MUD) (mis)matched unrelated cord blood (CB), a haplo-identical or a mismatched family donor can be considered as alternative graft sources. (frontiersin.org)
- Intra-bone marrow-BMT (IBM-BMT) provides distinct advantages because it recruits donor-derived hematopoietic stem cells and mesenchymal stem cells. (omicsonline.org)
- In animal experiments, intra-bone marrow-BMT (IBM-BMT) has been shown to efficiently recruit not only donor-derived hematopoietic stem cells (HSCs) but also mesenchymal stem cells (MSCs) [ 5 , 10 , 11 ]. (omicsonline.org)
- If you receive stem cells from a donor, the transplanted stem cells may attack your body. (cdc.gov)
- They have extensive experience in bone marrow transplants in both adult and paediatric patients. (parkwaycancercentre.com)
- Non-chemotherapy induced hemorrhagic cystitis is usually documented later after hematopoietic stem cell transplants (more than two weeks in the allogeneic setting). (haematologica.org)
- Our aim is to change the way in which bone marrow/hematopoietic stem cell transplants are performed and improve their efficacy. (hemogenyx-ir.com)
- Other conditions treated with stem cell transplants include sickle-cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease and Hodgkin's disease. (wikipedia.org)
- In 2006 a total of 50,417 first hematopoietic stem cell transplants were reported as taking place worldwide, according to a global survey of 1327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
- Other conditions treated with stem cell transplants include sickle-cell disease , myelodysplastic syndrome , neuroblastoma , lymphoma , Ewing's Sarcoma , Desmoplastic small round cell tumor , Hodgkin's disease , and multiple myeloma . (bionity.com)
- Among his promising projects: A study indicating that bone marrow transplants may be effective in treating systemic mastocytosis, a rare blood disease with no known cure, and the use of vaccines to replace antivirals which can often spawn deadly infections. (cityofhope.org)
- Stem cell transplants have many benefits, but they also have risks. (cdc.gov)
- Because stem cell transplants destroy and rebuild your immune system, they increase your risk for fungal infections. (cdc.gov)
- Chung NG, Kim M (2014) Current insights into inherited bone marrow failure syndromes. (springermedizin.de)
- Gluckman E, Wagner JE (2008) Hematopoietic stem cell transplantation in childhood inherited bone marrow failure syndrome. (springermedizin.de)
- Peffault de Latour R, Peters C, Gibson B et al (2015) Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes. (springermedizin.de)
- Alter BP (2007) Diagnosis, genetics, and management of inherited bone marrow failure syndromes. (springermedizin.de)
- Tsangaris E, Klaassen R, Fernandez CV et al (2011) Genetic analysis of inherited bone marrow failure syndromes from one prospective, comprehensive and population-based cohort and identification of novel mutations. (springermedizin.de)
- Allogeneic hematopoietic stem cell transplantation for inherited bone marrow failure syndromes. (telomerescience.com)
- Inherited bone marrow failure (IBMF) syndromes are a heterogeneous group of rare hematological disorders characterized by the impairment of hematopoiesis, which harbor specific clinical presentations and pathogenic mechanisms. (telomerescience.com)
- Indications for autologous and allogeneic hematopoietic cell transplantation: guidelines from the american society for blood and marrow transplantation. (nature.com)
- Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. (nature.com)
- Dr. Milner is a board certified Pediatric Hematologist/Oncologist with particular expertise in blood and marrow transplantation. (rochester.edu)
- A retrospective European Society for Blood and Marrow Transplantation (EBMT) analysis by Czerw et al. (frontiersin.org)
- Determine the efficacy of intensive high dose chemotherapy consisting of topotecan, ifosfamide, and etoposide followed by autologous bone marrow or peripheral blood stem cell transplantation in terms of response rate, progression free survival, and overall survival in patients with high risk non-Hodgkin's lymphoma or Hodgkin's lymphoma. (knowcancer.com)
- Patients undergo autologous bone marrow or peripheral blood stem cell transplantation on day 0. (knowcancer.com)
- Lack of persistent remission following initial recovery in patients with type 1 diabetes treated with autologous peripheral blood stem cell transplantation. (bioportfolio.com)
- To assess metabolic control in patients with newly diagnosed type 1 diabetes mellitus who underwent immunoablation followed by autologous peripheral blood stem cell transplantation (APBSCT) as a treat. (bioportfolio.com)
- Haematopoietic stem cell transplantation (or bone marrow transplantation as it is more commonly known) is a specialised procedure, which is effective in treating many types of cancers as well as some non- malignant conditions. (parkwaycancercentre.com)
- Given the rapidly rising healthcare costs, it is important to understand the economic costs of hematopoietic cell transplantation (HCT), a procedure that is being used more frequently in the treatment of various hematologic disorders. (bloodjournal.org)
- Stem cell transplantation is a medical procedure in the fields of hematology and oncology , most often performed for people with diseases of the blood , bone marrow , or certain types of cancer . (bionity.com)
- 6 Department of Hematology, Second Affiliated Hospital, Sun Yat-Sen University, Guangdong Province, PR China and 7 Guangdong Saliai Stem Cell Research Institute, Guangdong Province, PR China. (ovid.com)
- 8 Department of Hematology and Bone Marrow Transplantation, University of Parma, Parma 43126, Italy. (sciencemag.org)
- Using a gene targeting strategy to conditionally express the different Notch receptors and DSL ligands at defined stages of in vitro ES cell differentiation and in vivo hematopoiesis, they hope to delineate the effects of Notch signaling on lineage specification and self-renewal of progenitors at various stages of hematopoietic commitment. (rochester.edu)
- Donors administered growth factors prior to harvesting could sometimes undergo complications like bone pain and splenic rupture. (medindia.net)
- Anderson-Reitz L. Complications of hematopoietic cell transplantation. (cancer.ca)
- This section describes and discusses genitourinary system (GUS) complications of bone marrow transplantation (BMT). (renalandurologynews.com)
- Therefore, we have provided common GUS complications and the phases they frequently occur post-transplantation below. (renalandurologynews.com)
- PURPOSE: Phase II trial to study the effectiveness of T-cell depleted bone marrow and G-CSF stimulated peripheral stem cell transplantation in treating patients with leukemia, lymphoblastic lymphoma, myelodysplastic syndrome, or aplastic anemia. (clinicaltrials.gov)
- In recent years, bone marrow transplantation has been accepted as the definitive treatment of aplastic anemia not responding to medical treatment. (hubpages.com)
- Bone marrow transplantation (BMT) is a powerful strategy for the treatment of leukemia, aplastic anemia, congenital immunodeficiency and autoimmune diseases. (omicsonline.org)
- Patients with leukemia or lymphoma who undergo hematopoietic-cell transplantation (HCT) and survive can expect full recovery to take 3-5 years, according to a study published in the May 19 issue of The Journal of the American Medical Association (JAMA). (news-medical.net)
- Patients achieving maximal response following 2 courses of induction chemotherapy undergo transplantation. (knowcancer.com)
- Successful allogeneic bone marrow transplantation for myelodysplastic syndrome complicated by severe pulmonary alveolar proteinosis. (springer.com)
- If they are not available, donors may also be found in national and international bone marrow registries. (medindia.net)
- A buccal swab can be used for human leukocyte antigen (HLA) typing of bone marrow donors. (medscape.com)
- Buccal swabs are typically obtained at the time of bone marrow registry enrollment for all potential donors. (medscape.com)
- Hematopoietic cell transplantation (HCT) is an important treatment modality for many benign and malignant hematologic disorders. (bloodjournal.org)
- Hematopoietic cell transplantation (HCT) is often a last resort, but potentially curative treatment option for children suffering from hematological malignancies and a variety of non-malignant disorders, such as bone marrow failure, inborn metabolic disease or immune deficiencies. (frontiersin.org)
- Together, these data demonstrate that genome-edited HSPCs engraft, and contribute to multilineage repopulation after autologous transplantation in a clinically relevant large animal model, an important step toward the development of stem cell-based genome-editing therapies for HIV and potentially other diseases as well. (nih.gov)
- This book provides a unique and comprehensive resource of protocols for the genetic modification of various hematopoietic cell types and up-to-date procedures for molecular and systemic monitoring. (springer.com)
- Hematopoietic stem-cell transplantation in systemic sclerosis: an update. (bioportfolio.com)