Spinal Cord Neoplasms
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
A pathologic change in leukemia in which leukemic cells permeate various organs at any stage of the disease. All types of leukemia show various degrees of infiltration, depending upon the type of leukemia. The degree of infiltration may vary from site to site. The liver and spleen are common sites of infiltration, the greatest appearing in myelocytic leukemia, but infiltration is seen also in the granulocytic and lymphocytic types. The kidney is also a common site and of the gastrointestinal system, the stomach and ileum are commonly involved. In lymphocytic leukemia the skin is often infiltrated. The central nervous system too is a common site.
Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.
Bone Marrow Cells
Spinal Cord Compression
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
Colony-Forming Units Assay
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
A surgical procedure that entails removing all (laminectomy) or part (laminotomy) of selected vertebral lamina to relieve pressure on the SPINAL CORD and/or SPINAL NERVE ROOTS. Vertebral lamina is the thin flattened posterior wall of vertebral arch that forms the vertebral foramen through which pass the spinal cord and nerve roots.
The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.
Leukemia, Myeloid, Acute
The first of four extra-embryonic membranes to form during EMBRYOGENESIS. In REPTILES and BIRDS, it arises from endoderm and mesoderm to incorporate the EGG YOLK into the DIGESTIVE TRACT for nourishing the embryo. In placental MAMMALS, its nutritional function is vestigial; however, it is the source of INTESTINAL MUCOSA; BLOOD CELLS; and GERM CELLS. It is sometimes called the vitelline sac, which should not be confused with the VITELLINE MEMBRANE of the egg.
Bone Marrow Transplantation
A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
A dull red, firm, dome-shaped hemangioma, sharply demarcated from surrounding skin, usually located on the head and neck, which grows rapidly and generally undergoes regression and involution without scarring. It is caused by proliferation of immature capillary vessels in active stroma, and is usually present at birth or occurs within the first two or three months of life. (Dorland, 27th ed)
Core Binding Factor Alpha 2 Subunit
Spinal Cord Diseases
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Hematopoietic Stem Cell Transplantation
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Magnetic Resonance Imaging
A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Erythroid Precursor Cells
The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.
Technetium Tc 99m Sulfur Colloid
Leukemia, Myelomonocytic, Chronic
Neoplasms, Plasma Cell
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
GATA1 Transcription Factor
GATA2 Transcription Factor
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Soft Tissue Neoplasms
Myeloid Progenitor Cells
One of a pair of excretory organs (mesonephroi) which grows caudally to the first pair (PRONEPHROI) during development. Mesonephroi are the permanent kidneys in adult amphibians and fish. In higher vertebrates, proneprhoi and most of mesonephroi degenerate with the appearance of metanephroi. The remaining ducts become WOLFFIAN DUCTS.
Stem Cell Factor
Gene Expression Regulation, Developmental
Tomography, X-Ray Computed
Leukemia, Plasma Cell
Formation of LYMPHOCYTES and PLASMA CELLS from the lymphoid stem cells which develop from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW. These lymphoid stem cells differentiate into T-LYMPHOCYTES; B-LYMPHOCYTES; PLASMA CELLS; or NK-cells (KILLER CELLS, NATURAL) depending on the organ or tissues (LYMPHOID TISSUE) to which they migrate.
A benign tumor of the nervous system that may occur sporadically or in association with VON HIPPEL-LINDAU DISEASE. It accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. Histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. Usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. Cerebellar hemangioblastomas usually present in the third decade with INTRACRANIAL HYPERTENSION, and ataxia. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2071-2)
Hematopoietic Cell Growth Factors
These growth factors comprise a family of hematopoietic regulators with biological specificities defined by their ability to support proliferation and differentiation of blood cells of different lineages. ERYTHROPOIETIN and the COLONY-STIMULATING FACTORS belong to this family. Some of these factors have been studied and used in the treatment of chemotherapy-induced neutropenia, myelodysplastic syndromes, and bone marrow failure syndromes.
Graft vs Leukemia Effect
Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Platelet Membrane Glycoprotein IIb
Platelet membrane glycoprotein IIb is an integrin alpha subunit that heterodimerizes with INTEGRIN BETA3 to form PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX. It is synthesized as a single polypeptide chain which is then postranslationally cleaved and processed into two disulfide-linked subunits of approximately 18 and 110 kDa in size.
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
Bone Marrow Neoplasms
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proto-Oncogene Proteins c-myb
Fracture Fixation, Intramedullary
Intracranial or spinal cavities containing a cerebrospinal-like fluid, the wall of which is composed of arachnoidal cells. They are most often developmental or related to trauma. Intracranial arachnoid cysts usually occur adjacent to arachnoidal cistern and may present with HYDROCEPHALUS; HEADACHE; SEIZURES; and focal neurologic signs. (From Joynt, Clinical Neurology, 1994, Ch44, pp105-115)
A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
Proto-Oncogene Proteins c-kit
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Granulocyte Colony-Stimulating Factor
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Core Binding Factor beta Subunit
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Blood Cell Count
Janus Kinase 2
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
The process of generating white blood cells (LEUKOCYTES) from the pluripotent HEMATOPOIETIC STEM CELLS of the BONE MARROW. There are two significant pathways to generate various types of leukocytes: MYELOPOIESIS, in which leukocytes in the blood are derived from MYELOID STEM CELLS, and LYMPHOPOIESIS, in which leukocytes of the lymphatic system (LYMPHOCYTES) are generated from lymphoid stem cells.
Granulocyte-Macrophage Colony-Stimulating Factor
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Combined Modality Therapy
Graft vs Host Disease
Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Disease Models, Animal
Basic Helix-Loop-Helix Transcription Factors
Surgical Procedures, Minimally Invasive
Intrathoracic extramedullary haematopoiesis complicated by massive haemothorax in alpha-thalassaemia. (1/220)Intrathoracic extramedullary haematopoiesis (EMH) is a rare entity that is usually asymptomatic. A 44 year old man with alpha-thalassaemia is described who developed dyspnoea and massive left sided haemothorax. The haemoglobin disorder was established by Hgb H staining and haemoglobin electrophoretic studies. The DNA analysis revealed it to be a case of double heterozygous terminal codon mutation with the genotype alphaalphaCS/alphaalphaT. Computed tomographic scanning and magnetic resonance imaging of the thorax showed multiple paravertebral masses which were found by thoracoscopic biopsy to be extramedullary haematopoiesis. Although no additional sclerosing pleurodesis or low dose radiation therapy was given, the lung expanded well and there has been no recurrence of haemothorax to date. (+info)
Relapse in chronic myeloid leukemia after bone marrow transplantation: biomathematical modeling as a new approach to understanding pathogenesis. (2/220)A biomathematical model was developed to simulate relapse development in patients with chronic myeloid leukemia (CML) following bone marrow transplantation (BMT). The purpose of this study was to better understand the pathophysiology of the time evolution of CML relapse and to provide means whereby the outcomes of patients with CML relapse can be projected and treatment modified accordingly. The model consists of three parallel series of catenated compartments representing granulopoiesis in normal (donor) cells from the marrow, in CML cells from the marrow, and in CML cells from extramedullary sites. It was assumed that CML stem cells were resistant to feedback control and that CML-derived neutrophils, as well as normal neutrophils, exercised feedback regulation of normal stem cells. The known longer generation times for CML neutrophil precursors compared with normal neutrophil precursors were used, and it was assumed that 10(7) pluripotential stem cells were infused with BMT. The model was evaluated for its ability to simulate the reappearance of CML (Philadelphia chromosome positive) metaphases in the marrow and the recovery pattern in the blood neutrophil count in six patients who had relapsed following BMT (allogeneic in three patients, allogeneic with T-cell depletion in two patients, and syngeneic in one patient). The variables tested included the site of origin of the CML stem cells responsible for relapse (marrow alone versus marrow and extramedullary sites), the minimum number of CML stem cells responsible for relapse, and the time delay between BMT and the onset of relapse. Model profiles based on the observed values were obtained in each case. The simulations pointed to the fact that relapse began from a small number of CML cells in medullary and extramedullary sites. The time delay between BMT and the onset of relapse varied from 15 to 240 days. We suggest that this biomathematical model should be further investigated as a possible means of predicting outcome and guiding the treatment for patients with CML relapsing after BMT. (+info)
Extramedullar B lymphopoiesis in liver schistosomal granulomas: presence of the early stages and inhibition of the full B cell differentiation. (3/220)Inflammatory granulomatous reactions in liver elicited by schistosomal infection have been shown to function as active extramedullar myelopoietic sites, producing potentially all the myeloid lineages. We have now addressed the question of the extramedullar B lymphopoiesis in these sites. We have shown the presence of early B cell precursors (pro-B cells) in the granulomas by immunophenotyping. Their total number in the liver was equivalent to the pro-B cells in the bone marrow of one femur. In agreement with their phenotype, the RT-PCR analysis showed that these cells expressed RAG-1 and lambda5 genes. However, the conversion of the pro-B to pre-B cells was not observed and no clonogenic B cell precursors could be detected in semi-solid cultures stimulated by IL-7. The granulomatous stroma was shown to produce IL-7 and express c-kit, and was able to sustain the full B lymphopoiesis in vitro. Conversely, the granuloma supernatant was shown to inhibit actively the development of B lymphocytes. We conclude that the granuloma environment elicits homing and proliferation of totipotent hematopoietic precursors, and that it is permissive for early commitment to the B cell lineage, but the full extramedullar production of B cell is abrogated by soluble factors produced inside the granulomas. (+info)
Enhanced autoimmune arthritis in IFN-gamma receptor-deficient mice is conditioned by mycobacteria in Freund's adjuvant and by increased expansion of Mac-1+ myeloid cells. (4/220)Induction of experimental autoimmune diseases often relies on immunization with the organ-specific autoantigens in CFA, which contains heat-killed mycobacteria. In several of these models, including collagen-induced arthritis, endogenous IFN-gamma acts as a disease-limiting factor in the pathogenesis of the disease. Here we show that in collagen-induced arthritis the protective effect of IFN-gamma depends on the presence of mycobacteria in the adjuvant. Omission of mycobacteria inverts the role of endogenous IFN-gamma to a disease-promoting factor. Thus, the mycobacterial component of CFA opens a pathway by which endogenous IFN-gamma exerts a protective effect that supersedes its otherwise disease-promoting effect. Extramedullary hemopoiesis and expansion of the Mac-1+ cell population accompanied the accelerated and more severe disease course in the IFN-gamma receptor knockout mice immunized with CFA. Treatment of such mice with Abs against the myelopoietic cytokines IL-6 or IL-12 inhibited both disease development and the expansion of the Mac-1+ population. We postulate that mycobacteria in CFA stimulate the expansion of the Mac-1+ cell population by a hemopoietic process that is restrained by endogenous IFN-gamma. These results have important implications for the validity of animal models of autoimmunity to study the pathogenesis and to evaluate cytokine-based therapy of autoimmune diseases. (+info)
RANK is essential for osteoclast and lymph node development. (5/220)The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated by generating RANK-deficient mice. RANK(-/-) mice were characterized by profound osteopetrosis resulting from an apparent block in osteoclast differentiation. RANK expression was not required for the commitment, differentiation, and functional maturation of macrophages and dendritic cells from their myeloid precursors but provided a necessary and specific signal for the differentiation of myeloid-derived osteoclasts. RANK(-/-) mice also exhibited a marked deficiency of B cells in the spleen. RANK(-/-) mice retained mucosal-associated lymphoid tissues including Peyer's patches but completely lacked all other peripheral lymph nodes, highlighting an additional major role for RANK in lymph node formation. These experiments reveal that RANK provides critical signals necessary for lymph node organogenesis and osteoclast differentiation. (+info)
Increased fetal and extramedullary hematopoiesis in Fas-deficient C57BL/6-lpr/lpr mice. (6/220)In this study, we examined the consequences of Fas deficiency on hematopoiesis in C57BL/6-lpr/lpr mice. We found a striking extramedullary increase in hematopoietic progenitor cells, comprising erythroid and nonerythroid lineages alike. These modifications preceded the lymphadenopathy, because early progenitors (colony-forming units-spleen [CFU-S] day 8) were already augmented in day-18 fetal livers of the lpr phenotype. Three weeks after birth, CFU-S increased in peripheral blood and spleen and colony-forming cells (CFU-C) began to accumulate 1 to 3 weeks later. Extramedullary myelopoiesis augmented progressively in Fas-deficient mice, reaching a maximum within 6 months. By then, mature and immature myeloid cells had infiltrated the spleen, the liver, and the peritoneal cavity. Similar changes occurred in C57BL/6-gld/gld mice, indicating that they resulted from Fas/FasL interactions. Medullary hematopoiesis was not significantly modified in adult mice of either strain. Yet, the incidence of CFU-S decreased after Fas cross-linking on normal bone marrow cells in the presence of interferon gamma, consistent with a regulatory function of Fas/FasL interactions in early progenitor cell development. These data provide evidence that Fas deficiency can affect hematopoiesis both during adult and fetal life and that these modifications occur independently from other pathologies associated with the lpr phenotype. (+info)
The glucocorticoid receptor is required for stress erythropoiesis. (7/220)The glucocorticoid receptor (GR) coordinates a multitude of physiological responses in vivo. In vitro, glucocorticoids are required for sustained proliferation of erythroid progenitors (ebls). Here, we analyze the impact of the GR on erythropoiesis in vivo, using GR-deficient mice or mice expressing a GR defective for transactivation. In vitro, sustained proliferation of primary ebls requires an intact GR. In vivo, the GR is required for rapid expansion of ebls under stress situations like erythrolysis or hypoxia. A particular, GR-sensitive progenitor could be identified as being responsible for the stress response. Thus, GR-mediated regulation of ebl proliferation is essential for stress erythropoiesis in vivo. (+info)
Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. (8/220)We investigated roles of alpha4 integrins during hematopoiesis using mutant and chimeric mice. Yolk sac erythropoiesis and migration of hematopoietic progenitors to fetal liver, spleen, and bone marrow can occur without alpha4 integrins. Although terminal differentiation of these progenitors is possible without alpha4 integrins, these receptors are essential to maintain normal hematopoiesis in fetal liver, spleen, and bone marrow microenvironments. Moreover, alpha4-deficient erythroid progenitors and pre-B cells neither transmigrate beneath the stroma nor expand-properly in vitro. In contrast, alpha4-null cells migrate and differentiate efficiently into T lymphocytes within the thymus. In summary, alpha4 integrins are essential for normal development of all hematopoietic lineages in fetal liver, bone marrow, and spleen, likely by regulating the proliferation/differentiation balance of hematopoietic progenitors. (+info)
Extramedullary hematopoiesis of the sphenoid sinus associated with hereditary spherocytosis: A case report<...
TY - JOUR. T1 - Extramedullary hematopoiesis of the sphenoid sinus associated with hereditary spherocytosis. T2 - A case report. AU - Densky, Jaron. AU - Patel, Tirth. AU - Halderman, Ashleigh. AU - Malhotra, Prashant. PY - 2018/11/1. Y1 - 2018/11/1. N2 - Extramedullary hematopoiesis is a rare cause of a sinonasal mass that presents unique diagnostic and treatment challenges. While there are numerous reports of patients with hereditary spherocytosis developing extramedullary hematopoiesis in the posterior mediastinum, involvement in the paranasal sinuses has not previously been described. Here, we present the first case of a patient with hereditary spherocytosis developing extramedullary hematopoiesis in the sphenoid sinus.. AB - Extramedullary hematopoiesis is a rare cause of a sinonasal mass that presents unique diagnostic and treatment challenges. While there are numerous reports of patients with hereditary spherocytosis developing extramedullary hematopoiesis in the posterior mediastinum, ...
Main myelofibrosis (PMF) commonly results in extramedullary hematopoiesis (EMH) in the - DNA Damage Signalling and Repair...
Main myelofibrosis (PMF) commonly results in extramedullary hematopoiesis (EMH) in the spleen and liver as well as a variety of additional organs. biopsy exposed a hypercellular marrow moderately improved reticulin fibrosis and features consistent with main myelofibrosis. Abdominal imaging showed a normal-size spleen and did not determine any sites of EMH outside of the liver. The analysis of myelofibrosis was therefore made and this case shown predominant tropism to a transplanted freebase liver graft with absence of EMH elsewhere. We would therefore like to emphasize that findings of EMH in subjects with no preexisting hematologic neoplasm should warrant close follow-up and assessment. 1 Introduction Classified like a BCR-ABL bad myeloproliferative neoplasm  myelofibrosis is definitely a clonal cell malignancy characterized by progressive bone marrow fibrosis and ineffective erythropoiesis . Extramedullary hematopoiesis is definitely a well-recognized trend of this disease process. ...
Paraplegia due to extramedullary hematopoiesis in thalassemia treated successfully with radiation therapy | Haematologica
Extramedullary hematopoiesis (EMH) can occur in many disorders including thalassemias, polycythemia rubra vera, myelofibrosis, hemolytic anemia and other hemoglobinopathies. Spinal cord compression due to EMH in thalassemia was first reported by Gatto in 1954.2 It usually has a predilection for the lower thoracic spine where the limited mobility and narrow spinal canal predisposes itself to spinal cord compression.3,6 Most cases present with paraparesis, sensory impairment and occasionally sphincter disturbances. Complete paraplegia has been reported very rarely in thalassemia and occurs more frequently in polycythemia rubra vera and sickle cell anemia.1 The diagnostic procedure of choice is magnetic resonance imaging (MRI) which characteristerically shows an isointense mass with a high spinal intensity rim on T1-weighted images and a hyperintense mass on T2-weighted images.4 The diagnosis is based on strong clinical suspicion in the presence of diffuse bone marrow hyperplasia along with ...
Sabinet | Extramedullary haematopoiesis causing spinal cord compression : case report
Extramedullary haematopoiesis (EMH) is a rare cause of spinal cord compression. When a patient with a haematological disorder that causes chronic anaemia (particularly thalassaemia) presents with neurological deficits referable to the spine, EMH with paraspinal masses should be considered and imaging planned appropriately.
A case of paraparesis due to extramedullary haemopoiesis in HbE-thalassaemia. | Postgraduate Medical Journal
A 24-year-old female with haemoglobin E-thalassaemia who presented with paraparesis of 18 months duration was found to have spinal extradural extramedullary haemopoietic tissue extending from T4 to T9. Complete neurological recovery followed laminectomy. The importance of prompt diagnosis and treatment, of this unusual complication of extramedullary haemopoiesis, before the spinal cord is irreversibly damaged is stressed.. ...
Hepatosplenomegaly with Extramedullary Hematopoiesis & Overfolded Superior Helix & Seizure: Causes & Reasons - Symptoma
Hepatosplenomegaly with Extramedullary Hematopoiesis & Overfolded Superior Helix & Seizure Symptom Checker: Possible causes include FGFR2-Related Bent Bone Dysplasia. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Papanicolaou Society of Cytopathology Case of the Month February 2014
Trilinear hematopoiesis (TH) can occur in thyroidal aspirations by one of three mechanisms: as mass-forming extramedullary hematopoiesis (EMH), as marrow elements within thyroidal metaplastic bone or as marrow elements in aspirated ossified neck cartilage. Extramedullary hematopoiesis is a dynamic process of blood cell development occurring outside the confines of the medullary cavity of bone often in the settings of hypoxia, inflammation and bone marrow failure. Several case reports exist of EMH in various organs mimicking a mass and being discovered on fine needle aspiration. Although liver, spleen and lymph nodes are the most common sites, thyroid EMH can also occur. In a 2008 review, Westhoff et al. found that EMH of the thyroid most often occurs in older patients and is most likely secondary to a myelophthisic disease, such as myelofibrosis or metastatic bone marrow disease. Some reported cases of EMH in the thyroid have been attributable only to chronic anemia and still other cases have ...
Search Results | jns
Ectopic extramedullary hematopoiesis (EMH), defined as the formation of blood cells outside the bone marrow, usually occurs in a scenario of chronic anemia when, even after conversion of the bony yellow marrow to red marrow, the body is still unable to meet the demand for red blood cells. Ectopic extramedullary hematopoiesis most commonly occurs in the liver and spleen but may, in fact, occur almost anywhere in the body. Although previous reports have documented EMH presenting as paraspinal masses, such lesions have almost always been associated with a predisposing hematological disorder such as hemolytic anemia, myelofibrosis or myelodysplastic syndromes, thalassemia, polycythemia vera, leukemia, or lymphoma.. The authors of this report describe the first reported instance of EMH in a patient presenting with a symptomatic epidural and paraspinal cervical lesion arising from the posterior spinal elements and no known predisposing hematological disease. Initial radiographs revealed a bony lesion ...
JCI - Spleen mediates a distinct hematopoietic progenitor response supporting tumor-promoting myelopoiesis
Cancer progression is associated with alterations of intra- and extramedullary hematopoiesis to support a systemic tumor-promoting myeloid response. However, the functional specialty, mechanism, and clinical relevance of extramedullary hematopoiesis (EMH) remain unclear. Here, we showed that the heightened splenic myelopoiesis in tumor-bearing hosts was not only characterized by the accumulation of myeloid precursors, but also associated with profound functional alterations of splenic early hematopoietic stem/progenitor cells (HSPCs). With the distinct capability to produce and respond to granulocyte-macrophage CSF (GM-CSF), these splenic HSPCs were primed and committed to generating immunosuppressive myeloid cells. Mechanistically, the CCL2/CCR2 axis-dependent recruitment and the subsequent local education by the splenic stroma were critical for eliciting this splenic HSPC response. Selective abrogation of this splenic EMH was sufficient to synergistically enhance the therapeutic efficacy of ...
Final Diagnosis -- Case 690
DIAGNOSIS Multiple intracranial meningeal extramedullary hematopoiesis DISCUSSION EMH occurs as a compensatory mechanism in a variety of disorders characterized by a chronic hematopoietic deficit such as thalassemia major and intermedia, congenital spherocytosis and sickle cell anemia, and bone marrow dysfunction seen in myelofibrosis and carcinomatosis. Lymphoma and leukemia can also result in EMH. Intracranial EMH is rare. The pathway of EMH involvement of the dura is unknown, but it is postulated that the dura has hematopoietic capacity in the fetus and EMH may originate from primitive rests. In addition, the epidural space is a potential space that can harbor metastatic or heterotopic tissue deposits. Various hypotheses exist to explain the development of hemopoietic tissue to supplement marrow production. Lyall  proposed the possibility of direct extension from marrow into epidural space. Knoblich  proposed that multipotential cells in the epidural space can be transformed into marrow ...
Phenotype Image Detail
Light microscopy of livers in 17.5dpc Adatm1Mw/Ada+ and Adatm1Mw/Adatm1Mw mice. A: Liver in Adatm1Mw/Ada+ fetuses has normal sized hepatocytes with centrally located nuclei and granular or vacuolated cytoplasm (arrows). Extramedullary hematopoiesis characterized by megakaryocytes (m) and erythrocytic or granulocytic precursor cells (arrowheads) can be seen in the hepatic sinusoids. B: Adatm1Mw/Adatm1Mw fetus with enlarged hepatocytes (arrows) and marked extramedullary hematopoiesis in sinusoids adjacent to affected hepatocytes (arrowheads)> Scale bar: 32um ...
Oat bran blueberry muffin recipe, Cookingnook.com | Cookingnook.com
Quick and easy oat bran blueberry muffin recipe that can be turned easily into an oat bran apple muffin or apricot oat muffins. Tasty and full of nutrition.
Information Processing: EMH vs Macro, Fischer Black
EMH: what on earth is Kling talking about? He says: Consider financial variables, such as the long-term interest rate or the price-earnings ratio of the overall stock market. According to the efficient markets hypothesis, these are not predictable on the basis of known information. You might find quotes from the 60s or 70s saying something like this, but the modern interpretation, I think, is simply that information is reflected in asset prices. That still leaves things like risk premiums to move around in predictable ways. Theres no end of working trying to do this in both finance and macro. I read the whole post (Klings, I mean), and with due respect to his offer to take the most charitable view of those who disagree, Id have to say the post is more confusing than helpful. Is that charitable enough, or do I need to work on it a bit more? ...
Delineation of cellular niches which support hematopoiesis in spleen by Helen ONeill, H. K. Lim et al.
Hematopoietic stem cell (HSC) niches in bone marrow have been described in terms of distinct cell types including osteoblastic, endothelial and perivascular reticular cells. However, niches which support extramedullary hematopoiesis in other sites like spleen remain to be elucidated. Previous studies have described splenic stromal cells which support hematopoiesis in vitro from purified HSC and multipotential progenitors (MPP) leading to the production of dendritic-like cells. Stromal cell lines were originally derived from splenocyte cultures, and later as freshly isolated stromal subsets prepared by enzymatic digestion and sorting. Transcriptome analysis has revealed that stroma which support hematopoiesis express many genes in parallel with perivascular cells described in bone marrow. They share a common mesenchymal lineage with perivascular cells in bone marrow, as well as mesenchymal progenitor cells and CXCL12-abundant reticular cells. They reflect osteoprogenitors in that cells can be induced to
Influenced by the Wrong Crowd | Science Signaling
Two studies by Walkley et al. investigated the role of intrinsic and extrinsic factors in regulating cell cycle and fate of hematopoietic stem cells (HSCs), which reside in specialized niches in the bone marrow and give rise to the cells of the hematopoietic system (see Perry and Li). Although most HSCs maintain a relatively quiescent state, they can be stimulated to enter the cell cycle when hematopoiesis is required. The retinoblastoma (RB) tumor suppressor plays a critical role in cell cycle regulation and, in the first study, Walkley et al. examined the effects of Rb deletion on hematopoiesis. Widespread loss of RB throughout the mouse hematopoietic system led to profound myeloproliferation, characterized by an increase in the numbers of circulating progenitor cells and extramedullary hematopoiesis. There was a loss of trabecular bone (a HSC niche) and HSCs from the bone marrow, and eventual hematopoietic failure. When RB loss was restricted to cells of the myeloid lineage (granulocytes, ...
Myelofibrosis - Dog
Affected dogs usually present with a normocytic, normochromic nonregenerative anemia, neutropenia and thrombocytopenia. Diagnosis requires multiple bone marrow core biopsies and histological examination of other organ tissue samples, confirming the increased presence of fibrosis within bone marrow spaces and increased extramedullary hematopoiesis in other organs such as the liver and spleen. There is no specific treatment for this condition apart from long-term prednisolone, erythropoietin and addressing the underlying cause of this disease. In severely anemic dogs, whole blood transfusions of fresh frozen plasma may be required as a palliative strategy to forestall a demise. Development of new protein kinase inhibitors has shown promise at treating myelofibrosis secondary to lymphoma. ...
JCI - Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease
Oncogenic ras alleles are among the most common mutations found in patients with acute myeloid leukemia (AML). Previously, the role of oncogenic ras in cancer was assessed in model systems overexpressing oncogenic ras from heterologous promoters. However, there is increasing evidence that subtle differences in gene dosage and regulation of gene expression from endogenous promoters play critical roles in cancer pathogenesis. We characterized the role of oncogenic K-ras expressed from its endogenous promoter in the hematopoietic system using a conditional allele and IFN-inducible, Cre-mediated recombination. Mice developed a completely penetrant myeloproliferative syndrome characterized by leukocytosis with normal maturation of myeloid lineage cells; myeloid hyperplasia in bone marrow; and extramedullary hematopoiesis in the spleen and liver. Flow cytometry confirmed the myeloproliferative phenotype. Genotypic and Western blot analysis demonstrated Cre-mediated excision and expression, ...
JCI - Fatal myeloproliferation, induced in mice by TEL/PDGFβR expression, depends on PDGFβR tyrosines 579/581
The t(5;12)(q33;p13) translocation associated with chronic myelomonocytic leukemia (CMML) generates a TEL/PDGFβR fusion gene. Here, we used a murine bone marrow transplant (BMT) assay to test the transforming properties of TEL/PDGFβR in vivo. TEL/PDGFβR, introduced into whole bone marrow by retroviral transduction, caused a rapidly fatal myeloproliferative disease that closely recapitulated human CMML. TEL/PDGFβR transplanted mice developed leukocytosis with Gr-1+ granulocytes, splenomegaly, evidence of extramedullary hematopoiesis, and bone marrow fibrosis, but no lymphoproliferative disease. We assayed mutant forms of the TEL/PDGFβR fusion protein - including 8 tyrosine to phenylalanine substitutions at phosphorylated PDGFβR sites to which various SH2 domain-containing signaling intermediates bind - for ability to transform hematopoietic cells. All of the phenylalanine (F-) mutants tested conferred IL-3-independence to a cultured murine hematopoietic cell line, but, in the BMT assay, ...
Mesenchymal stromal cells in myeloid malignancies
Taking into account the physiological relevance of the BM microenvironment, several investigators have tested the hypothesis if genetic alterations of niche cells are capable of inducing myeloid malignancies. This idea challenges the well-accepted concept that MDS and AML originate exclusively from HSPC-intrinsic genetic defects.. First evidence for niche-driven myeloid disorders came from a series of murine experiments with deletions of the Retinoblastoma gene, the retinoic acid receptor gamma (RAR-γ), IκBα or the Notch ligand endocytosis regulator Mib1 [16, 17, 18, 19]. In all experimental systems, mice developed a myeloproliferative disease phenotype characterized by leukocytosis, extramedullary hematopoiesis and splenomegaly. These studies highlighted that genetic changes of non-hematopoietic elements of the BM microenvironment can directly contribute to disease initiation. Still, in some of these experiments, simultaneous deletion of the candidate gene in hematopoietic and surrounding ...
The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity...
Dendritic cells (DCs) regulate both immunity and tolerance. Here we have shown that the ubiquitin editing enzyme A20 (Tnfaip3) determines the activation threshold of DCs, via control of canonical NF-kappa B activation. Tnfaip3(fl)/(fl)Cd11c-cre(+) mice lacking A20 in DCs demonstrated spontaneous proliferation of conventional and double-negative T cells, their conversion to interferon-gamma (IFN-gamma)-producing effector cells, and expansion of plasma cells. They developed ds-DNA antibodies, nephritis, the antiphospholipid syndrome, and lymphosplenomegaly-features of systemic lupus erythematosus-and extramedullary hematopoiesis. A20-deficient DCs were resistant to apoptosis, caused by increased sensitivity to CD40L and RANKL prosurvival signals and upregulation of antiapoptotic proteins Bcl-2 and Bcl-x. They captured injected apoptotic cells more efficiently, resisted the inhibitory effects of apoptotic cells, and induced self-reactive effector lymphocytes. Because genetic polymorphisms in ...
Mutagenetix > Incidental...
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal susceptibility to bacterial infection despite decreased T and B cell proliferation and extramedullary hematopoiesis in the spleen. [provided by MGI curators ...
The incidence of lung tumors was studied in hyperoxic and hypoxic pregnant A mice given injections intravenously of 25 mg. of urethan, and in their offspring. Among progeny born within 24 hours after their mothers received urethan, those born in an environment of approximately 100 per cent or 10 per cent O2 developed a significantly greater number of pulmonary tumors than did controls born in room air. The average number of tumors decreased significantly in all progeny from mothers given injections earlier than 24 hours prepartum. Myeloid leukemia and extramedullary hematopoiesis were also induced or potentiated by urethan. Mothers in all groups had more pulmonary tumors than their offspring had; 48-hour exposure resulted in an increased average number for mothers kept hyperoxic, as compared with those kept hypoxic or in room air. Mothers in all three groups developed a high incidence of mammary carcinomas.. ...
Glycemic Index Forum / Sugar Busters Forum | Old Fashioned Blueberry Muffins
Preheat oven to 350. (Says to line muffin cups with 10 liners) Sift together flour, baking powder, salt. Set aside. Beat together margarine, Splenda and honey(agave nectar) with an electric mixer until light and fluffy. Add eggs one at a time beating well after each addition. Stir in vanilla. Alternately stir in flour mixture and milk, beginning and ending with flour mixture. Fold in berries ...
Whats In Your Blueberry Muffin?
TODAY correspondent Jeff Rossen reveals to consumers that the fruit often found in processed foods is not really fruit at all. Food products such as muffins, cereal and drinkable yogurt contain ingredients like oil and sugar to approximate the look and taste of fruit.
Banana & blueberry muffins recipe | BBC Good Food
A low-fat muffin that tastes as good as it looks - theyll keep in an airtight container for up to 3 days, or freeze for up to a month, from BBC Good Food
Banana & blueberry muffins recipe | BBC Good Food
A low-fat muffin that tastes as good as it looks - theyll keep in an airtight container for up to 3 days, or freeze for up to a month, from BBC Good Food
How To Lose Your Muffin Top And Boast a Lean Torso - Vitaguard | Health
You cant see visceral fat. It hides around your liver and kidneys, intestines and reproductive system. Visceral fat clings to your organs. It can add 3 to 6 inches to your waist and hips even after you lose most of the pooch and muffin top.. The Internet, Facebook, and YouTube portray hundreds of exercise programs claiming to get rid of muffin tops. The beautiful and well-intentioned young men and women who present them (most of whom never had a muffin top) seem to have forgotten their high school human biology. Fat oxidation (fat burn) by the body is unrelated to the particular muscles being worked. Fat is taken from throughout the body and used through a complex process to provide energy. No matter how hard you do these exercises, you will not budge the muffin.. Heres the bottom line: You are exercising particular muscles. You are not exercising the fat that surrounds them. You are hardly affecting that fat at all. A solid hour of muffin top exercises in the gym uses less than half an ounce ...
25 Muffin Recipes with Fruit | EatingWell
Bake some fruit-filled muffins this weekend with these delicious recipes. These muffins can be made with any fruit-including berries, apples and bananas. Feel free to use fresh, frozen or dried fruit, depending on what you have on hand. Recipes like Whole-Wheat Strawberry Muffins, Lemon-Raspberry Muffins and Banana Oat Muffins are healthy, tasty and will make your kitchen smell absolutely amazing.
Best 25+ Protein muffins ideas on Pinterest | Banana protein muffins, Healthy breakfast muffins and Protein banana bread
Find and save ideas about Protein muffins on Pinterest. | See more ideas about Banana protein muffins, Healthy breakfast muffins and Protein banana bread.
Dual Roles of Fer Kinase Are Required for Proper Hematopoiesis and Vas by Aaron P. Putzke, Emily M. Dunn et al.
Fer kinase, a protein involved in the regulation of cell-cell adhesion and proliferation, has been shown to be required during invertebrate development and has been implicated in leukemia, gastric cancer, and liver cancer. However, in vivo roles for Fer during vertebrate development have remained elusive. In this study, we bridge the gap between the invertebrate and vertebrate realms by showing that Fer kinase is required during zebrafish embryogenesis for normal hematopoiesis and vascular organization with distinct kinase dependent and independent functions. In situ hybridization, quantitative PCR and fluorescence activated cell sorting (FACS) analyses revealed an increase in both erythrocyte numbers and gene expression patterns as well as a decrease in the organization of vasculature endothelial cells. Furthermore, rescue experiments have shown that the regulation of hematopoietic proliferation is dependent on Fer kinase activity, while vascular organizing events only require Fer in a kinase
To RH Milroy From EMH beck June 19 1863 :: General Robert H. Milroy
1st Division Cav. Corps. Hosp. Alpine Creek, Va. Dear Robt. June 19th/63 Since writing you the other day I talked with Dr. Hand Surgeon-in-Chief of our division as to my course or prodedure to get with you. He could conjecture but one of two ways. I must be newly appointed by govt. as Surgeon of volunteers, involving an examination of 6 days the severest & I am told by arm med. corps. inspector, ungentleman- ly & malicious castra- tion ((as they the examiners), are able regulars & prejudiced against innovation) in the way of an examination ...
Banana Beet Muffins | City Market / Onion River Co-op
Preheat oven to 375 degrees F. Line a 12-cup muffin tin with muffin papers.. In a large bowl, combine flour, oats, baking powder, baking soda, salt, nutmeg and cinnamon. In a separate bowl combine banana, oil, maple syrup and eggs. Stir until smooth.. Stir the banana mixture into the flour mixture until just mixed, then stir in beets. Scoop 1/3-cup portions of batter into muffin tins, and bake for 18-20 minutes. Test with a toothpick inserted in muffins. If the toothpick emerges with wet batter, bake an additional 5 minutes. Remove from pan and let cool before serving.. ...
Craz4acop and Many Other Things: June 2005
The day started off in a nice calm..NORMAL manner. Cat woke up first and came and crawled in bed with me. Ash woke up about 15 minutes later, observed that her Daddy was working today, and decided she was hungry. So I get out of bed and go to the kitchen to make some strawberry and blueberry muffins. Yum! 15 minutes in the oven and they are done. Called Alan, he came by to grab a few. The girls were settled at the kitchen table eating muffins, munching on the remainder of the KIX cereal they started while the muffins were cooking, and drinking their milk. They were content. Everything was as it should be. I quickly ate two muffins and drained the last of my own milk from my glass. Then I started thinking. I guess that was my first mistake. Surely, I thought surely since they are SO content, I can take 5 minutes to throw on my clothes...and maybe even get to pee without their company if Im quick. Ever the prevenative mom, I looked around the kitchen to double check things just in case. All ...
Ruby Chocolate Muffins Recipe
Preheat oven to 350F. Line muffin tin with paper or silicone cups or use a nonstick pan, and set aside. In a mixing bowl, whisk flour, cocoa, baking powder, and sugar together. Add applesauce and nondairy milk, and stir until just combined. Stir in chocolate chips and cranberries, plus extract (if using). Spoon into prepared muffin tin and bake 15-20 minutes, until the muffins are firm to the touch and a toothpick inserted in the center comes out clean.. ...
Muffin Man 100mL
Muffin Man 100mL Do you know the Muffin Man? Its a savory apple muffin topped with cinnamon crumbs and a rich overtone that will make you smile.
Team Nico! - Team Nico Wellness Warriors!
So we resumed normal life, thinking of the ER visits as pit stops, and went about our business. That was until I visited a coffee shop by our house and got a muffin for Nico. We have eaten muffins and scones from this place for years. The teenaged kid recommended a power muffin, the white board at the drive-thru indicated a few of the ingredients that all sounded healthy and unappetizing but I got the muffin anyway. I handed it over to Nico and long story short, the power muffin was actually a peanut butter muffin. I have never heard of such a thing. Usually there are nuts sprinkled on top when a muffin has nuts in the mix, but there was no evidence of peanuts in this. When Nico started to vomit and cry (after less than a bite), I tore the muffin open looking for nuts. I was sure that I did not see nuts listed on the ingredients, but his reaction was too similar to the time he ate cashew butter. I had a bad cold by then, so I couldnt smell it. In less than an hour, and in spite of a large ...
Video: Lemon Poppy-Seed Muffin | Martha Stewart
Calling all muffin fans, Sarah Carey makes one of her all time favorites, a Lemon Poppy Seed Muffin, thats perfectly sized and incredibly delightful. Its truly one of the best muffins ever!
My cat muffins paw is swollen. About 2 days ago she licks the side of her paw but not the bottom. Muffin
My cat muffins paw is swollen. About 2 days ago she licks the side of her paw but not the bottom. Muffin - Answered by a verified Cat Veterinarian
Calories in Carrot Cake Muffins, No Oil - Large Muffins - Calorie, Fat, Carb, Fiber, and Protein Info | SparkRecipes
Full nutritional breakdown of the calories in Carrot Cake Muffins, No Oil - Large Muffins based on the calories and nutrition in each ingredient, including Flour, white, Brown Sugar, Egg, fresh, whole, raw, Applesauce, sweetened, Carrots, raw and the other ingredients in this recipe.
Calories in Thomas English Muffin W/ Penut Butter - Calorie, Fat, Carb, Fiber, and Protein Info | SparkRecipes
Full nutritional breakdown of the calories in Thomas English Muffin W/ Penut Butter based on the calories and nutrition in each ingredient, including Peanut Butter, smooth style, with salt, Thomas Original English Muffin (1 muffin 57g) and the other ingredients in this recipe.
Week of January 21 Soups and Muffins - Earth Angel Vegan
SORRY, NO SOUPS OR MUFFINS WILL BE AVAILABLE FOR WEEK OF JANUARY 28TH. Soups are available for pick up at 2208 Paul Street unless you order meals then you may be eligible for delivery. Soups & Muffins must be ordered by Friday at noon for the following week. Soups & Muffins are 100% plant based…
Dr Nima Gunness
Baking meets science in the most delicious way, with a range of new good heart muffins developed by Centre scientists at the UQ node to meet the food standard guidelines for cholesterol-lowering properties. According to food scientist and keen baker Dr Nima Gunness, the UQ blueberry muffins contain around three grams of beta glucans - […]. ...
Outcome of Cytogenetics in Patients with Newly Diagnosed Extramedullary Myeloma Undergoing Stem-Cell Transplantation -...
N. Gagelmann, D.J. Eikema, L. Koster, D. Caillot, P. Pioltelli, et al.. Outcome of Cytogenetics in Patients with Newly Diagnosed Extramedullary Myeloma Undergoing Stem-Cell Transplantation. 1st Meeting of the European-Myeloma-Network, Apr 2018, Turin, Italy. pp.42. ⟨hal-02048979⟩ ...
Calories in Cosi Carrot Muffin | Nutrition, Carbohydrate and Calorie Counter
There are 470 calories in 1 muffin (5.3 oz) of Cosi Carrot Muffin. Youd need to walk 123 minutes to burn 470 calories. Visit CalorieKing to see calorie count and nutrient data for all portion sizes.
Calories in Fiber One Banana Chocolate Chip Muffin | Nutrition, Carbohydrate and Calorie Counter
There are 180 calories in 1 muffin (2.3 oz) of Fiber One Banana Chocolate Chip Muffin. Youd need to walk 47 minutes to burn 180 calories. Visit CalorieKing to see calorie count and nutrient data for all portion sizes.
Dixie USA Carb Counters Muffin Mix Select at Netrition.com.
Dixie USA Carb Counters Muffin Mix Select is a low carb, gluten free muffin mix that is all natural, has no artificial ingredients, and no preservatives. Just add eggs, sour cream and butter.
Chicago Metallic 44555 Glazed Aluminum Large-Crown 20 Cup Muffin Pan | Wasserstrom
These non-stick muffin pans make perfect large-crown muffins every time. No need to oil before baking.|br||ul class=staticList||li|Model #: 44555|/li||li|Material: 16 gauge aluminized steel|/li||li|Wire in rim|/li||li|AMERICOAT Plus®|/li||/ul|
MuffinMonday: Chocolate Cinnamon Muffins | Baker Street
Spoon into the prepared muffin cases. Sprinkle the remaining ¼ cup chocolate chips on top and then bake for 20 minutes or until the muffins are dark, risen and springy ...
Thomas Seasonal Variation English Muffin | 13 Oz. | English Muffins | Hannaford
Thomas Seasonal Variation English Muffin found at Hannaford Supermarket. Add to online shopping list or grocery cart for Hannaford To Go.
BLUEBERRY MUFFIN NICOTINE JUICE - MADTOWN VAPOR
A fresh blueberry muffin with a light cinnamon topping. Steeping time 5-7 days. Please select the options to complete your nicotine juice order. Our 100% USA made Nicotine juice comes in a variety of blends and strengths. The Blueberry Muffin nicotine juice is made with the highest quality flavors and ingredients and will satisfy your taste buds and nicotine cravings. The Blueberry Muffin Nicotine Juice is freshly mixed when you order so you will never get any old product from us. All our e-juices ship out within 24 hours of order time. Most of the time sooner. If you have any questions, comments, or concerns please send us a email via our contact page or call us at (608)285-2006. All our nicotine juice is made with the following ingredients. Food Flavoring. Vegetable Glycerin 99.7% USP Kosher. Propylene Glycol USP Nicotine. WARNING: MadTown Vapor e-Liquid products may contain nicotine, a poisonous and addictive substance. MadTown Vapor products are intended for use by persons of legal age or ...
New blueberry muffin may lower heart disease risk | Business Standard...
Read more about New blueberry muffin may lower heart disease risk on Business Standard. Scientists have developed a new blueberry muffin recipe that may help decrease the risk of heart diseases by lowering cholesterol levels in the blood. The Good heart muffin contains three grammes of beta glucans - a healthy soluble fibre that
Gluten Free Blueberry Muffins - Celiac Disease
Although Ive always enjoyed the gluten free blueberry muffin mixes you can buy in the stores, some people prefer their muffins to be completely homemade. For these people, here is a gluten free recipe for blueberry muffins that I highly recommend! ...
First Street Label Blueberry Muffin, Loaf Recall [US]
US/Silver Spring: Bubbles Baking Co. recalls 9,229 cases of First Street Label Blueberry Muffins and Blueberry Loaf Cakes due to undeclared milk and soy hazards. FDA: http://ht.ly/oWdTj Direct link: http://www.fda.gov/Safety/Recalls/ucm367888.htm Additional information: The US Food and Drug Administration (FDA) reports the following Snack Foods are subject to this recall: First Street Label Blueberry Muffins, 14-ounce package and…
Buy Quest Nutrition Blueberry Muffin Protein Bar from Canada at Well.ca - Free Shipping
Quest Nutrition Blueberry Muffin Protein Bar - For years, streusel-topped, buttery blueberry muffins have been calling out to you in the latte line
Calories in Nutrisystem Breakfast, Blueberry Muffin - Nutritional Information and Diet Info
Comprehensive nutrition resource for Nutrisystem Breakfast, Blueberry Muffin. Learn about the number of calories and nutritional and diet information for Nutrisystem Breakfast, Blueberry Muffin. This is part of our comprehensive database of 40,000 foods including foods from hundreds of popular restaurants and thousands of brands.
Calories in Kinnikinnick Foods Blueberry Muffins - Nutritional Information and Diet Info
Comprehensive nutrition resource for Kinnikinnick Foods Blueberry Muffins. Learn about the number of calories and nutritional and diet information for Kinnikinnick Foods Blueberry Muffins. This is part of our comprehensive database of 40,000 foods including foods from hundreds of popular restaurants and thousands of brands.
Nephrotic syndrome associated with agnogenic myeloid metaplasia | AVESİS
Extramedullary hematopoiesis being an important feature of agnogenic myeloid metaplasia (AMM), a chronic myeloproliferative disease of clonal origin, may affect the kidneys, but this condition is usually asymptomatic. Until now, there is only one reported case of nephrotic syndrome associated with AMM. We present a patient with AMM who had nephrotic syndrome and whose renal biopsy revealed membranous glomerulonephritis together with renal extramedullary hematopoiesis. ...
Paraplegia due to a paravertebral extramedullary haemopoiesis in a patient with polycythaemia vera | Journal of Clinical...
In July 1985, a 43-year-old man was found to have polycythaemia vera. The peripheral blood counts were white cell count 14.15×109/l (neutrophils 80%, lymphocytes 14%, monocytes 5%, eosinophils 1%), haemoglobin concentration 24.8 g/dl, haematocrit 0.7, red cell count 8.15×1012/l (neither anisocytosis nor poikilocytosis nor tear-drop poikilocytosis were observed), platelets 234×109/l. As only the erythroid lineage was affected significantly, he was treated with isovolaemic phlebotomy until April 2004. In May 2004, the patient suddenly developed a spastic paraplegia. Nuclear magnetic resonance imaging showed a posterior extradural tumour extending from T3 to T11 … ...
Blueberry Muffins | Magnesium Blue
These scrumptious little yummies have been a favorite weekend breakfast in our home for years. To be exact a little over four years. I know this because after giving Birth to Maya my home birth midwife returned to our house the next morning with a basket of freshly baked muffins. It was just what I needed and wanted after delivering our first baby girl! Healthy, low in fat, high in fiber, not too sweet, moist and filling. This is her recipe.. Blueberry Muffins. 1 cup flour. 1 cup bran. 1/3 cup rolled oats. 1/2 cup brown sugar. 1 egg. 1/2 cup oil ( I use light olive oil). 1 cup milk. 1 tsp baking soda. 1 cup fresh blueberries. Method. Pre-heat oven to 400˚ Combine flour, bran, sugar and soda. Stir until mixed. Add milk, eggs, oil and stir well. Add oats and blueberries. Bake in lined muffin tin for 12-15 minutes.. Note: you can use any fruit with this basic bran muffin recipe, grated apple, bananas, raisins, carrot raspberries….have fun and enjoy!. ...
Cannon Drive Relocation - EMH&T
The Ohio State University, Columbus, OH. The improved Cannon Drive corridor on the Medical Campus of The Ohio State University provides enhanced connectivity between the campus and the Olentangy River by creating a restored greenway along the river, while also providing a more efficient transportation route to improve traffic flow and accessibility through critical areas of the University campus. The EMH&T Visualization team played a key role within the larger EMH&T-led project team, assisting with the preliminary design and visualization of several roadway and river levee alignment options as well as preliminary grading. The quickness and increased level of accuracy allowed the design team to provide the best design possible that considers construction costs, safety, connectivity, construction sequencing and more. With the 3D model being designed to accurate grades and with actual road design criteria, the engineering design team was able to develop plans based on the model as a starting point ...
Lactose Free Banana and Blueberry Muffins recipe - All recipes Australia NZ
Beautifully soft on the inside with a slight crunch to the outside, these muffins beat traditionally blueberry muffins and have the added deliciousness of banana. Especially great served warm and straight out of the oven! Best eaten a day or two after theyre made though they will store for 3 days in an airtight container. Totally addictive and very much lactose free so theyre easy to digest!
Celebrate National Blueberry Muffin Day With These Recipes | Health.com
Today is National Blueberry Muffin Day! To celebrate this classic breakfast and snack food, were sharing two recipes for these berrylicious muffins (one of which is vegan).
The Bakery at Walmart Gluten-Free Blueberry Muffins - Celiac.com
My first impression after trying one of The Bakery Gluten-Free Blueberry Muffins was that these muffins are super-moist, and taste great.
Nakd Blueberry Muffin : Cereal bars : Animal Aid Shop
Animal Aid Shop Nakd Blueberry Muffin - Healthy tea break, tasty snack just fruits and nuts and blueberries. Soft, sweet and full of goodness. Made from 100% natural ingredients and one of your five-a-day. Gluten free. Made by Natural Balance.
Fred Meyer - Quest Blueberry Muffin Protein Bars 12 Count, 1.6 lb
Shop for Quest Blueberry Muffin Protein Bars 12 Count at Fred Meyer. Find quality products to add to your Shopping List or order online for Delivery or Pickup.
Sugar Blueberry Muffins No (large Egg Whites) Recipes | Foodily
See all results for Sugar Blueberry Muffins No (large Egg Whites) Recipes. Find more recipes at Foodily.com - the largest recipe search site - and see the ones your friends like.
Blueberry Muffins | Bread | Nilssons Ambrosia
I have made these blueberry muffins a few times now and its a hit every time. This time a baked a double portion as we had two events this weekend. First for Sillas game night with the guys on Friday and on Saturday we went to the park for a birthday party for sweet little two-year-old girl. T
Quest Protein Bars Blueberry Muffin Box Box of 12 | Vitamin World
Blueberry Muffin Quest Bars are delicious protein bars that make a healthy snack with 21g protein and 14g fiber. Try it now at Vitamin World!
Buy Barry M Cosmetics Gelly Nail Paint - Blueberry Muffin | Nail polish | Argos
Buy Barry M Cosmetics Gelly Nail Paint - Blueberry Muffin at Argos. Thousands of products for same day delivery £3.95, or fast store collection.
Artificial Blueberry Muffin Mix · dry | 407 calories | Happy Forks
Not only calories. Artificial Blueberry Muffin Mix dry is rich in folate (54%), sodium (51%), carbohydrate (32%), protein (9%). See details.
Blueberry muffins Fact, Health Benefits & Nutritional Value
Blueberry muffins is Carbohydrate and Sodium rich food which support to form protein, repair cells, balance hormones, extract energy and chemical reaction.
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Excellent and durable response to radiotherapy in a rare case of spinal cord compression due to extra-medullary hematopoiesis...
Excellent and durable response to radiotherapy in a rare case of spinal cord compression due to extra-medullary hematopoiesis in β-thalassemia intermedia: case report and clinicoradiological correlation
Study to Compare Busulfan-fludarabine With Thiotepa-fludarabine Regimen in Allogeneic Transplantation for Myelofibrosis - Full...
This is the first study to explore the efficacy of two different Reduced-intensity conditioning (RIC) regimens for allogeneic stem cell transplantation in myelofibrosis. The choice of 60 patients is based on feasibility reasons. GITMO data at hand points to an estimated accrual of twenty patients per year over a tree-year enrolment period. Criteria for defining sample size do not follow statistical power estimates in order to demonstrate the difference of lack of it between two treatments. However, the criteria reflect the overall efficacy and safety of comparing the two treatments among all patients requiring the treatment within the health system. This criterion offers the best estimate for power of study.. Myelofibrosis is a clonal hematopoietic stem cell disorder that is clinically characterized by progressive anemia, marked splenomegaly, extramedullary hematopoiesis, constitutional symptoms and a significant risk of evolution into acute leukaemia myelofibrosis can appear as a primitive or ...
The Turkish Journal of Pediatrics
Yetgin S, Yalçın SS. The effect of vitamin D3 on CD34 progenitor cells in vitamin D deficiency rickets. Turk J Pediatr 2004; 46: 164-166.. Vitamin D metabolites have multiple functions not only in calcium homeostasis, but also in hematopoiesis. To detect the effect of vitamin D on hematopoiesis with a surface glycoprotein marker, the proportions of the CD34+ cells were measured in bone marrow, peripheral blood and spleen prior to and after vitamin D3 treatment in an infant with severe rickets, myelofibrosis and myeloid metaplasia. CD34+ cells measured 0.4% in bone marrow, 8.0% in peripheral blood and 8.7% in splenic aspirate. The detection of a high and comparable level of CD34+ cells in both peripheral blood and splenic aspirate on admission and the decline in the level of CD34+ cells (2%) following treatment support that CD34+ cells were from extramedullary hematopoiesis in spleen. The improvement of rickets and hematological findings with treatment at the same time raises the possibility of ...
Conventional and experimental drug therapy in myelofibrosis with myeloid metaplasia
Myelofibrosis with myeloid metaplasia (MMM) is currently classified as a classic (ie, BCR-ABL-negative) myeloproliferative disorder characterized by anemia, multiorgan extramedullary hematopoiesis, constitutional symptoms, and premature death from either leukemic transformation or other disease comp …
VetReview - Terapia intensiva veterinária: Falta de associação entre os achados ultrassonográficos e o diagnóstico...
Results: Histological diagnoses were hepatitis (n=77), nodular hyperplasia (n=47), vacuolar change (n=45), fibrosis (n=32), primary hepatic carcinoma (n=30), lymphoma (n=28), metastatic neoplasia (n=27), necrosis (n=21), lipidosis (n=17), haemangiosarcoma (n=13), round cell tumour (n=9), hepatocellular adenoma (n=8), degenerative change (n=6), steroid hepatopathy (n=7) and extramedullary haematopoiesis (n=4). The most prevalent ultrasonographic features were multifocal lesions (63% livers with haemangiosarcoma and 43% livers with hepatocellular carcinoma), diffuse lesions (71% livers with steroid hepatopathy, 44% livers with fibrosis and 40% livers with vacuolar hepatopathy), hyperechoic lesions (71% livers with steroid hepatopathy, 41% livers with lipidosis and 38% livers with fibrosis), heterogeneous lesions (62% livers with haemangiosarcoma), hepatomegaly (43% livers with steroid hepatopathy) and peritoneal fluid (62% livers with haemangiosarcoma). Target lesions were associated with ...
Cases from the Osler Medical Service at Johns Hopkins University. Diagnosis: Polymorphic population of mature and immature...
Semantic Scholar extracted view of Cases from the Osler Medical Service at Johns Hopkins University. Diagnosis: Polymorphic population of mature and immature hematopoietic cells consistent with extramedullary hematopoiesis. by Jennifer S. Myers et al.
Elinluvs Sweet Delights: Seaweed Muffins
I used Sarahs silicone friand mold and some extra aluminium foil cupcakes mold for making these muffins. I kind of love the ingredients that make up this muffins....first , the use of shortening and icing sugar attracted me to want to try this out. The desire to want to know the outcome...whether the texture is soft , moist or hard is so great and thus the urge to make them :p It turned out great and I love the springy like but yet moist texture of this muffins. The aroma of bacon bits and seaweed wafting from the oven woke up the wild boar and he had his share at 12am a very early breakfast I guess...I took took one ...too hard to resist them since they came out so fragrant :) The seaweed powder I bought was from the 100Yen shop and it makes the muffins special and fragrant. These muffins are light unlike those classic muffins are more compact. Love it and WB is oinking for more and smsed me to add more bacon to it :) * I am smiling as I am typing this post out....as I seldom want to repeat ...
Sclerosing extramedullary hematopoietic tumor: emphasis on diagnosis by renal biopsy<...
TY - JOUR. T1 - Sclerosing extramedullary hematopoietic tumor. T2 - emphasis on diagnosis by renal biopsy. AU - Sukov, William R.. AU - Remstein, Ellen D.. AU - Nascimento, Antonio G.. AU - Sethi, Sanjeev. AU - Lewin, Matthew. PY - 2009/4/1. Y1 - 2009/4/1. N2 - Sclerosing extramedullary hematopoietic tumor (SEMHT) is a rare lesion that typically arises in patients with chronic myeloproliferative disorders. Morphologically, it exhibits atypical megakaryocytes, granulocytic precursors, and erythroid precursors set in a background of dense collagen sclerosis. Sclerosing extramedullary hematopoietic tumor may be easily mistaken for other neoplasms, such as sarcoma, carcinoma, or Hodgkin lymphoma, particularly if pertinent clinical history is not provided. Misdiagnosis may occur because of the difficulty in recognizing the megakaryocytic lineage of the atypical cells and because of the paucity of other hematopoietic elements. We report a case of a 72-year-old man with proteinuria and renal ...
Learning to Eat Allergy-Free: Allergen-Free Blueberry Muffins
Ive made these twice now and theyre wonderfully fluffy and normal which can be hard to come by in this world of alternative baking!! While we dont have any allergies, after suffering since I was a teenager I have now learned to avoid FODMAPS and my oldest son (at the tender young age of 8 years old) has some anorexia issues coupled with a strong fear of meat, eggs and dairy soooo meals at our house are very tricky. I adjusted your recipe to sneak in some nutrition for my vegan with eggs and cultured dairy and theyve turned out beautifully. Thanks so much for sharing your gift!! I know that none of us would wish to have struggled with what so many are blessed to take for granted - way to go making lemonade out of these lemons ...
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Extramedullary disease portends poor prognosis in multiple myeloma and is over-represented in high-risk disease even in the era...
Results The most common sites for extramedullary disease at diagnosis were skin and soft tissue whereas liver involvement was the striking feature in extramedullary disease at disease relapse or progression. Regardless of therapy, extramedullary disease was associated with shorter progression-free and overall survival, as well as the presence of anemia, thrombocytopenia, elevated serum lactate dehydrogenase, cytogenetic abnormalities, and high-risk features in 70-and 80-gene risk models in univariate analysis. Multivariate analysis with logistic regression revealed that this disease feature was more prevalent in patients with an elevated centrosome index, as determined by gene expression profiling, as well as in myeloma molecular subtypes that are more prone to relapse. These include the MF subtype (also called the MAF subtype, associated with over-expression of the MAF gene seen with chromosome translocation 14;16 or 14;20) and the PR subtype (also called the Proliferation subtype, ...
Intramedullary versus extramedullary fixation in the management of sub | CIA
Intramedullary versus extramedullary fixation in the management of subtrochanteric femur fractures: a meta-analysis Pengcheng Liu,1,2,* Xing Wu,1,* Hui Shi,1,2 Run Liu,1 Hexi Shu,1 JinPeng Gong,1 Yong Yang,1 Qi Sun,1 Jiezhou Wu,1,2 Xiaoyang Nie,1 Ming Cai1 1Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine, Shanghai, 2First Clinical Medical College, Nanjing Medical University, Nanjing, People’s Republic of China *These authors contributed equally to this work Background: Intramedullary and extramedullary fixation methods are used in the management of subtrochanteric femur fractures. However, whether intramedullary or extramedullary fixation is the primary treatment for subtrochanteric femur fractures in adults remains debatable.Level of evidence: Meta-analyses of prospective studies, level I.Materials and methods: The Cochrane library, Embase, Google Scholar, and PubMed databases were searched separately for all relevant studies published
Best 25+ Healthy breakfast muffins ideas on Pinterest | Healthy banana muffins, Banana oatmeal muffins and Banana recipes clean
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Muffin recipes - Kidspot
Muffins are perfect as an after school snack, teatime treat or a lunch box surprise. be they sweet or savoury, theres a muffin recipe to suit every tastebud and weve got them all here. Enjoy basic vanilla muffins, 3-ingredient mini muffins and sneaky pumpkin muffins.
Sequence Similarity - 1EMH: CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO UNCLEAVED SUBSTRATE-CONTAINING...
1EMH: Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
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Blueberry Protein Muffins
This blueberry muffin recipe turned out awesome on my first try. As a result, I now feel like a Paleo baking goddess. So of course I had to share, so you can feel that way too!
Extramedullary hematopoiesis. Hemostasis. *Coagulation *Fibrinolysis. *Clot retraction. *Platelet adhesiveness. Other. * ...
Innate immune system
Extramedullary hematopoiesis. Myeloid tissue. Granulocytes. *Myeloblast. *Band cell. *Neutrophil. *Basophil *CFU-Baso ...
Video-assisted thoracoscopic surgery
VATS and Extramedullary Haematopoiesis. Eur Resp J 2006;28:255-6 Juan C Garzon, Calvin SH Ng, Alan D Sihoe, Anthony V Manlulu, ... Video assisted thoracoscopic surgery for mediastinal extramedullary haematopoiesis. Ann R Coll Surg Engl 2002;84:161-163 Calvin ...
Malignant infantile osteopetrosis
Additionally extramedullary hematopoiesis can result in liver and spleen dysfunction. Cranial nerve dysfunction and neurologic ...
Blueberry muffin baby
... (extramedullary hematopoiesis) due to congenital cytomegalovirus infection". Arch Pediatr Adolesc Med. ... Blueberry muffin baby is the characteristic distributed purpura occurring as a result of extramedullary hematopoiesis found in ...
"Sustained exposure to nicotine leads to extramedullary hematopoiesis in the spleen". Stem Cells. 24 (11): 2373-81. doi:10.1634/ ...
Other rare causes of hemothorax include neurofibromatosis type 1 and extramedullary hematopoiesis. Rarely, hemothoraces can ...
Martin A. Samuels
A 68 year old man with gait disorder (Paget's disease with extra-medullary hematopoiesis)". New England Journal of Medicine. ...
This is termed extramedullary erythropoiesis. The bone marrow of essentially all the bones produces red blood cells until a ... The tibia and femur cease to be important sites of hematopoiesis by about age 25; the vertebrae, sternum, pelvis and ribs, and ...
There may be evidence of extramedullary hematopoiesis (marrow elements can be found in the spleen, liver). Treatment of this ... Currently, the most common cause is displacement of bone marrow by metastatic cancer (extramedullary hematopoiesis tends to be ... leukoerythroblastosis is occurring because the displaced hematopoietic cells begin to undergo extramedullary hematopoiesis. ...
... with foci of extramedullary hematopoiesis. Microscopically, lymph nodes also contain foci of hematopoiesis, but these are ... The result is extramedullary hematopoiesis, i.e. blood cell formation occurring in sites other than the bone marrow, as the ... Another complication of extramedullary hematopoiesis is poikilocytosis, or the presence of abnormally shaped red blood cells.[ ... The principal site of extramedullary hematopoiesis in myelofibrosis is the spleen, which is usually markedly enlarged, ...
... causes extramedullary hematopoiesis in the fetal liver and bone marrow. The push to make more erythroblasts to help compensate ... Jagannathan-Bogdan, Madhumita; Zon, Leonard I. (2013-06-15). "Hematopoiesis". Development. 140 (12): 2463-2467. doi:10.1242/dev ...
Gray platelet syndrome
"Gray platelet syndrome with splenomegaly and signs of extramedullary hematopoiesis: a case report with review of the literature ...
Transient myeloproliferative disease
... enlarged spleen presumed due mostly to the portal hypertension accompanying liver disease with extramedullary hematopoiesis ... "Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis". The Journal of Clinical Investigation. 127 (4 ...
Hematopoietic stem cell
In the case of fetuses and other extramedullary hematopoiesis, Hematopoietic stem cells may also settle in the liver or spleen ... Haematopoiesis is the process by which all mature blood cells are produced. It must balance enormous production needs (the ... This process is called haematopoiesis. This process occurs in the red bone marrow, in the core of most bones. In embryonic ... In vertebrates, the vast majority of hematopoiesis occurs in the bone marrow and is derived from a limited number of ...
... extramedullary hematopoiesis (i.e. formation of blood cells outside of their normal site in the bone marrow), variable ... by promoting extramedullary hematopoiesis, and, possibly, by contributing to its leukemic transformation. GRCh38: Ensembl ... a malignant disease that involves the replacement of bone marrow cells by fibrous tissue and extramedullary hematopoiesis, i.e ... low GATA1 levels are also thought to promote the development of splenic enlargement and extramedullary hematopoiesis in human ...
... which leads to extramedullary hematopoiesis. There is one other sense of myeloid that means "pertaining to the spinal cord", ... In hematopoiesis, myeloid or myelogenous cells are blood cells that arise from a progenitor cell for granulocytes, monocytes, ... Orkin SH, Zon LI (2008). "Hematopoiesis: an evolving paradigm for stem cell biology". Cell. 132 (4): 631-644. doi:10.1016/j. ...
... extramedullary hematopoiesis of the spleen, and other problems. While not all of these clinical and pathological findings are ...
List of MeSH codes (G09)
... hematopoiesis MeSH G09.188.261.544.414 - erythropoiesis MeSH G09.188.261.544.463 - hematopoiesis, extramedullary MeSH G09.188. ...
Generalized arterial calcification of infancy
Dilated and hypertrophied ventricles Extramedullary hematopoiesis of liver Hypertrophy of myocardium Bright and hyper- ...
Congenital rubella syndrome
Low birth weight Thrombocytopenic purpura Extramedullary hematopoiesis (presents as a characteristic blueberry muffin rash) ...
... and hepatosplenomegaly due to bone expansion leading to bone marrow narrowing and extramedullary hematopoiesis It can also ...
Ectodermal dysplasia Extramedullary hematopoiesis Fragile X syndrome Hurler syndrome Osteopathia Striata with Cranial Sclerosis ... due to expansion of bone marrow secondary to increased hematopoiesis) Hallermann-Streiff syndrome Dennis, Mark; Bowen, William ... where there is increased hematopoiesis and enlargement of the medullary cavities of the skull. Rickets Achondroplasia ...
Ohio Extramedullary hematopoiesis, hematopoiesis occurring outside of the medulla of the bone This disambiguation page lists ...
... (EMH or sometimes EH) refers to hematopoiesis occurring outside of the medulla of the bone (bone ... If the loss of RBCs becomes severe, hematopoiesis will occur in the extramedullary spaces outside the bone. The cause of ... Sohawon D, Lau KK, Lau T, Bowden DK (October 2012). "Extra-medullary haematopoiesis: a pictorial review of its typical and ... Sohawon D, Lau KK, Lau T, Bowden DK (October 2012). "Extra-medullary haematopoiesis: a pictorial review of its typical and ...
This is called extramedullary haematopoiesis. It may cause these organs to increase in size substantially. During fetal ... Extramedullary hematopoiesis and myelopoiesis may supply leukocytes in cardiovascular disease and inflammation during adulthood ... Haematopoiesis (/hɪˌmætoʊpɔɪˈiːsɪs, ˈhiːmətoʊ-, ˌhɛmə-/, from Greek αἷμα, 'blood' and ποιεῖν 'to make'; also hematopoiesis in ... In children, haematopoiesis occurs in the marrow of the long bones such as the femur and tibia. In adults, it occurs mainly in ...
මානව කායිකවේදය - විකිපීඩියා, නිදහස් විශ්වකෝෂය
Extramedullary hematopoiesis. Hemostasis. Coagulation (Fibrinolysis) · Clot retraction · Platelet adhesiveness. Other. ...
T-Cell Acute Lymphoblastic Leukemia
... along with extramedullary involvement of multiple organs including the lymph node as a result of hyperleukocytosis. Originating ... hence suppressing normal hematopoiesis, resulting in deficiency of functioning peripheral blood cells (particularly ...
... also localizes to the bone marrow (BM), where it functions in hematopoiesis by inducing IL-6 and VEGF secretion, which ... Sevcikova S, Paszekova H, Besse L, Sedlarikova L, Kubaczkova V, Almasi M, Pour L, Hajek R (Apr 2015). "Extramedullary relapse ... The involvement of TBRG4 in hematopoiesis links it to multiple myeloma (MM), which stems from malignant proliferation of plasma ... TBRG4 is involved in cell proliferation in hematopoiesis and multiple myeloma. TBRG4 shares structural characteristics of the ...
Extramedullary hematopoiesis - Wikipedia
Extramedullary hematopoiesis (EMH or sometimes EH) refers to hematopoiesis occurring outside of the medulla of the bone (bone ... If the loss of RBCs becomes severe, hematopoiesis will occur in the extramedullary spaces outside the bone. The cause of ... Sohawon D, Lau KK, Lau T, Bowden DK (October 2012). "Extra-medullary haematopoiesis: a pictorial review of its typical and ... Sohawon D, Lau KK, Lau T, Bowden DK (October 2012). "Extra-medullary haematopoiesis: a pictorial review of its typical and ...
Extramedullary hematopoiesis (EMH)
... The CT scan of the chest revealed well-defined bilateral paraspinal masses in the lower ... Extramedullary hematopoiesis occurs as a compensatory mechanism for abnormal hematopoiesis when normal red marrow is unable to ... Extramedullary hematopoiesis should be considered in the differential diagnosis in a patient with chronic severe anemia and a ... Extramedullary hematopoiesis is the production of blood elements outside the bone marrow cavity. Until 20 weeks of prenatal ...
Adrenal Gland - Extramedullary Hematopoiesis - Nonneoplastic Lesion Atlas
Extramedullary Hematopoiesis and Liver - Extramedullary Hematopoiesis). EMH is typically composed of mixed myelopoietic and ... Adrenal gland, Cortex - Extramedullary hematopoiesis in a female F344/N rat from a chronic study. There is a focus of ... Adrenal gland, Cortex - Extramedullary hematopoiesis in a male F344/N rat from a chronic study. There are multiple foci of ... Adrenal gland, Cortex - Extramedullary hematopoiesis in a female B6C3F1/N mouse from a chronic study. There are several foci of ...
Extramedullary hematopoiesis mimicking hepatocellular carcinoma
... By Priya Bhosale, MD, Swarupa Gadre, MD, L. Jeffrey Medeiros, ... Focal intrahepatic extramedullary hematopoiesis presenting as fatty lesions. AJR Am J Roentgenol. 2004;182:1031-1032. ... Focal intrahepatic extramedullary hemat-opoiesis mimicking neoplasm. AJR Am J Roentgenol. 1987;149:1171-1172. ... Intrahepatic extramedullary hematopoietic tumor mimicking metastatic carcinoma from a colonic primary. Onkologie.2004;27:65-67. ...
JCI - 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy
Extramedullary hematopoiesis (EMH) is induced during pregnancy to support rapid expansion of maternal blood volume. EMH ... 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. ... 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. ... and EMH during pregnancy but normal bone marrow hematopoiesis and EMH in response to bleeding or G-CSF treatment. Distinct ...
Extramedullary haematopoiesis: an uncommon posterior mediastinal mass. - Free Online Library
Extramedullary haematopoiesis: an uncommon posterior mediastinal mass.(PICTORIAL INTERLUDE) by South African Journal of ... APA style: Extramedullary haematopoiesis: an uncommon posterior mediastinal mass.. (n.d.) >The Free Library. (2014). Retrieved ... MLA style: "Extramedullary haematopoiesis: an uncommon posterior mediastinal mass.." The Free Library. 2013 South African ... Extramedullary hematopoiesis: Findings on computed tomography scans of the chest in 6 patients. J Bras Pneumol 2008;34(10):812- ...
Cutaneous extramedullary hematopoiesis
... is a rare cutaneous manifestation of myelofibrosis, where hematopoiesis occurs in the ... Cutaneous extramedullary hematopoiesis. Subscriber Sign In VisualDx Mobile Feedback Select Language Share Enter a Symptom, ... Cutaneous extramedullary hematopoiesis in Adult. Print Images (6) Contributors: Vivian Wong MD, PhD, Whitney A. High MD, JD, ... Cutaneous extramedullary hematopoiesis in pre-term or full-term neonates is thought to be an accentuation of a normal ...
Intrathoracic extramedullary haematopoiesis | Postgraduate Medical Journal
A woman from the Middle East, in her fifth decade, known to have beta thalassemia while undergoing routine medical assessment was incidentally detected to have a mass lesion in the right lower zone on chest radiograph (figure 1). On clinical assessment she was found to have hepatosplenomegaly. Respiratory system examination was unremarkable. A CT was done, which revealed the presence of well-defined lobulated soft tissue attenuation masses in … ...
Extramedullary hematopoiesis within endothelial papillary hyperplasia (Masson s pseudoangiosarcoma) of the tongue
Palabras clave : Extramedullary hematopoiesis; intravascular endothelial papillary hyperplasia; tongue; thrombus organization. ... SANTONJA, Carlos; SUS, Jesús de y MORAGON, Manuel. Extramedullary hematopoiesis within endothelial papillary hyperplasia ( ... This association between a peculiar form of thrombus organization and extramedullary hematopoiesis has been reported previously ... and extramedullary hematopoiesis. The lesion was present as a violaceous nodule on the side of the tongue of a 78-year-old man ...
SPINAL CORD COMPRESSION DUE TO EXTRAMEDULLARY HEMATOPOIESIS* | Annals of Internal Medicine | American College of Physicians
SPINAL CORD COMPRESSION DUE TO EXTRAMEDULLARY HEMATOPOIESIS1 A. STEPHEN CLOSE, M.D.; YOSHIRA TAIRA, M.D.; DAVID A. CLEVELAND, M ... However, extramedullary hematopoiesis is found often in autopsy material from cases in which there is no detectable bone marrow ... SPINAL CORD COMPRESSION DUE TO EXTRAMEDULLARY HEMATOPOIESIS1. Ann Intern Med. 1958;48:421-427. doi: 10.7326/0003-4819-48-2-421 ... Extramedullary hematopoiesis, or myeloid metaplasia, is a frequently encountered condition, occurring usually in association ...
Primary Myelofibrosis Presenting as Extramedullary Hematopoiesis in a Transplanted Liver Graft: Case Report and Review of the...
Paraplegia due to extramedullary hematopoiesis in thalassemia treated successfully with radiation therapy | Haematologica
Extramedullary hematopoiesis (EMH) is a compensatory phenomenon and commonly involves the liver, spleen and lymph nodes. Spinal ... 1998) Spinal cord compression due to extramedullary hematopoiesis in beta-thalassemia intermedia. Int J Radiat Oncol Biol Phys ... 1998) Spinal cord compression secondary to extramedullary hematopoiesis in thalassemia intermedia. Eur Spine J 7:501-504. ... Extramedullary hematopoiesis (EMH) can occur in many disorders including thalassemias, polycythemia rubra vera, myelofibrosis, ...
Extramedullary haematopoiesis in the adrenal glands | BMJ Case Reports
Extramedullary hematopoiesis in the adrenal: case report and review of literature. Can Urol Assoc J 2013;7:436-8.doi:10.5489/ ... Extramedullary haematopoiesis presenting as an adrenal mass. J Clin Diagn Res 2017;11:TJ01.doi:10.7860/JCDR/2017/25086.9448pmid ... Extramedullary haematopoiesis (EMH) is the formation of cellular components of blood, occurring outside of the bone marrow. ... It is imperative to consider extramedullary haematopoiesis when adrenal enlargement is seen in patients with haematological ...
Splenic Extramedullary Hematopoiesis in a Patient Receiving Intermittently Administered Granulocyte ColonyStimulating Factor |...
Spleen sections showed extramedullary hematopoiesis but no lymphomatous involvement. To our knowledge, we report the first case ... Splenic Extramedullary Hematopoiesis in a Patient Receiving Intermittently Administered Granulocyte ColonyStimulating Factor ... Splenic Extramedullary Hematopoiesis in a Patient Receiving Intermittently Administered Granulocyte ColonyStimulating Factor. ... of splenomegaly with extramedullary hematopoiesis in a patient receiving intermittent G-CSF therapy. Clinicians should be aware ...
Sabinet | Extramedullary haematopoiesis causing spinal cord compression : case report
Extramedullary haematopoiesis (EMH) is a rare cause of spinal cord compression. When a patient with a haematological disorder ... Extramedullary haematopoiesis (EMH) is a rare cause of spinal cord compression. When a patient with a haematological disorder ... n SA Journal of Radiology - Extramedullary haematopoiesis causing spinal cord compression : case report * Navigate this Journal ...
Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological...
Extramedullary hematopoiesis (EMH) is defined as the presence of hematopoietic stem cells such as erythroid and myeloid lineage ... plus megakaryocytes in extramedullary sites like liver, spleen and lymph nodes and is usually associated with either bone ... Extramedullary hematopoiesis (EMH) is defined as the presence of hematopoietic stem cells such as erythroid and myeloid lineage ... Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological ...
Extramedullary Hematopoiesis Manifesting as a Symptomatic Pleural Effusion<...
"Extramedullary Hematopoiesis Manifesting as a Symptomatic Pleural Effusion",. abstract = "The occurrence of extramedullary ... The occurrence of extramedullary hematopoiesis in the pleura is rare and is usually asymptomatic. It is generally diagnosed on ... Extramedullary Hematopoiesis Manifesting as a Symptomatic Pleural Effusion. Rachelina P. Bartlett, Philip R. Greipp, Ayalew ... Bartlett, R. P., Greipp, P. R., Tefferi, A., Cupps, R. E., Mullan, B. P., & Trastek, V. F. (1995). Extramedullary Hematopoiesis ...
Intrahepatic extramedullary hematopoiesis: MR, CT, and sonographic appearance. - Semantic Scholar
A 45-year-old patient with focal intrahepatic extramedullary hematopoiesis is presented in which the liver was imaged by CT, ... Focal Tumor-like Splenic Extramedullary Hematopoiesis : a case report. Chen-Chu Chang, WU MING-MING, Lili Chen, Ya-Tang Yang, ... Extramedullary hematopoiesis presenting as a focal splenic mass: a case report. Adolf Singer, Pierre D. Maldjian, Marc Z. ... Massive intrahepatic extramedullary hematopoiesis in myelofibrosis. Marta Navarro, Concepción Crespo, +3 authors Isabel ...
An intracranial extramedullary hematopoiesis in a 34-year-old man with beta thalassemia: a case report | Journal of Medical...
Intracranial deposits of extramedullary hematopoiesis are an extremely rare compensatory process in intermediate and severe ... An intracranial extramedullary hematopoiesis, although extremely rare, should be considered as a potential ancillary diagnosis ... We present an unusual case of an intracranial extramedullary hematopoiesis with a choroid plexus origin in a 34-year-old ... Extramedullary hematopoiesis occurs in approximately 15% of cases of thalassemia. ...
Thalassemia Imaging: Practice Essentials, Radiography, Magnetic Resonance Imaging
The presence of extramedullary hematopoiesis within the spinal canal may be associated with the development of spinal cord ... Extramedullary hematopoiesis. Lobulated soft tissue opacities are noted overlying the ribs anteriorly and posteriorly. View ... Extramedullary hematopoiesis. Lobulated soft tissue opacities are noted overlying the ribs anteriorly and posteriorly. View ... Extramedullary hematopoiesis. In the most severely affected patients, and particularly in patients with thalassemia intermedia ...
IS case 503: Myelofibrotic extramedullary hematopoiesis
Splenomegaly is often a distinctive feature of myelofibrosis and is due to extramedullary hematopoiesis that can involve and ... On CT, splenic extramedullary hematopoiesis may appear as multiple hypodense mass lesions. These may demonstrate T1 ... IS case 503: Myelofibrotic extramedullary hematopoiesis. Jacinto Camarena III, MD University of Rochester ... specimens taken after splenectomy and a liver biopsy confirmed there was myelofibrotic extramedullary hematopoiesis. ...
GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental...
GMP accumulate in the BM in SpA and, unexpectedly, at extramedullary sites: in the inflamed joints and spleen. Furthermore, we ... a single dose of a microbial ligand curdlan induces persistent extramedullary myelopoiesis in the spleen and joints, which is ... Dysregulated hematopoiesis occurs in several chronic inflammatory diseases, but it remains unclear how hematopoietic stem cells ... show that GM-CSF promotes extramedullary myelopoiesis, tissue-toxic neutrophil accumulation in target organs, and GM-CSF ...
Hematopoiesis : Wikis (The Full Wiki)
This is called extramedullary haematopoiesis. It may cause these organs to increase in size substantially. During fetal ... Haematopoiesis (from Ancient Greek: haima blood; poiesis to make) (or hematopoiesis in the United States; sometimes also ... Granulopoiesis (or granulocytopoiesis) is haematopoiesis of granulocytes.. Megakaryocytopoiesis is haematopoiesis of ... Extramedullary. In some cases, the liver, thymus, and spleen may resume their haematopoietic function, if necessary. ...
Hepatosplenomegaly with Extramedullary Hematopoiesis & Overfolded Superior Helix & Seizure: Causes & Reasons - Symptoma
Hepatosplenomegaly with Extramedullary Hematopoiesis & Overfolded Superior Helix & Seizure Symptom Checker: Possible causes ... Extramedullary hematopoiesis leads to hepatosplenomegaly.  The extramedullary hematopoiesis leading to hepatosplenomegaly ... from extramedullary hematopoiesis due to bone red marrow replacement In all osteopetrosis (whether AD or AR) there is a ... from extramedullary hematopoiesis due to bone red marrow replacement In all osteopetrosis (whether AD or AR) there is a ...
Extramedullary hematopoiesis associated with organizing peritoneal hemorrhage: A report of 5 cases in patients presenting with...
N2 - Extramedullary hematopoiesis (EMH) usually occurs in patients with severe anemia or myelofibrosis, and involvement of the ... AB - Extramedullary hematopoiesis (EMH) usually occurs in patients with severe anemia or myelofibrosis, and involvement of the ... Extramedullary hematopoiesis (EMH) usually occurs in patients with severe anemia or myelofibrosis, and involvement of the ... Ardakani, N. M., Kumarasinghe, P., Spagnolo, D., & Stewart, C. (2014). Extramedullary hematopoiesis associated with organizing ...
October 2016 - Volume 23 - Issue 4 : Journal of Bronchology & Interventional Pulmonology
Extramedullary haematopoiesis presented as intrathoracic tumour in a patient with alpha-thalassaemia | Journal of...
The authors report a case of extramedullary haematopoiesis (EMH) presenting as an intrathoracic tumour in a patient with alpha- ... The authors report a case of extramedullary haematopoiesis (EMH) presenting as an intrathoracic tumour in a patient with alpha- ... Extramedullary haematopoiesis (EMH) is a compensatory phenomenon in hematological diseases with insufficient blood cell ... Verani R, Olson J, Moake JL: Intrathoracic extramedullary haematopoiesis: report of a case in a patient with sickle cell ...
Fibrinolysis - Wikipedia
Innate immune system - Wikipedia
AbstractLiverSplenomegalySpinal cord compreMyeloidMyelofibrosisSplenic Extramedullary HematopoiesisTrilineage hematopoiesisErythropoiesisDiagnosisBeta thalassemiaLymphMarrowIntracranialIntrathoracicAdrenal GlandPulmonaryMyelopoiesisChronicMegakaryocytesHereditaryPosteriorExtra-medullaryCutaneousChoroid plexusOccurThalassemia majorFindingsHematopoietic stemHyperplasiaMassesSevereHaematopoieticMyelodysplasticCaseTumors
- abstract = "The occurrence of extramedullary hematopoiesis in the pleura is rare and is usually asymptomatic. (elsevier.com)
- abstract = "Extramedullary hematopoiesis (EMH) usually occurs in patients with severe anemia or myelofibrosis, and involvement of the serous cavities is uncommon. (edu.au)
- abstract = "Extramedullary hematopoiesis is a rare cause of a sinonasal mass that presents unique diagnostic and treatment challenges. (elsevier.com)
- during this time the main site of fetal hematopoiesis are liver and the spleen. (wikipedia.org)
- During fetal development, hematopoiesis occurs mainly in the fetal liver and in the spleen followed by localization to the bone marrow. (wikipedia.org)
- 1 Extramedullary hematopoiesis mainly involves the RE system (liver, spleen, and lymph nodes) but is also known to occur in every organ of the body, including the thyroid, prostate, pericardium, kidney, and lungs. (appliedradiology.com)
- EMH is not commonly seen in the adrenal gland, so if it is present, it will likely also be present in other organs, most likely the spleen and liver (see Spleen - Extramedullary Hematopoiesis and Liver - Extramedullary Hematopoiesis ). (nih.gov)
- A core liver biopsy was performed underultrasound guidance and histologic examination led to the diagnosis of extramedullary hematopoiesis (EMH) with no morphologic evidence of a malignant neoplasm. (appliedradiology.com)
- Lemos LB, Baliga M, Benghuzzi HA, Cason Z. Nodular hematopoiesis of the liver diagnosed by fine-needle aspiration cytology. (appliedradiology.com)
- Primary myelofibrosis (PMF) commonly results in extramedullary hematopoiesis (EMH) in the spleen and liver as well as a variety of other organs. (hindawi.com)
- Extramedullary hematopoiesis (EMH) is a compensatory phenomenon and commonly involves the liver, spleen and lymph nodes. (haematologica.org)
- Extramedullary hematopoiesis (EMH) is defined as the presence of hematopoietic stem cells such as erythroid and myeloid lineage plus megakaryocytes in extramedullary sites like liver, spleen and lymph nodes and is usually associated with either bone marrow or hematological disorders. (biomedcentral.com)
- A 45-year-old patient with focal intrahepatic extramedullary hematopoiesis is presented in which the liver was imaged by CT, ultrasound, and MR. The appearance of the lesions on MR consisted of slightly increased signal on T2-weighted images with heterogeneous enhancement of some of the lesions during bolus infusion of gadolinium. (semanticscholar.org)
- In this patient, specimens taken after splenectomy and a liver biopsy confirmed there was myelofibrotic extramedullary hematopoiesis . (rochester.edu)
- The liver biopsy showed findings of extramedullary hematopoiesis within the sinusoids with increased atypical megakaryocytes. (ranscombehouseglynde.com)
- Usually, extramedullary myeloid proliferation occurs in liver, spleen and lymph nodes. (springer.com)
- Representative images of immunochemistry detection of the extramedullary hematopoiesis foci in liver of mice injected with 4T1 cancer cells. (aging-us.com)
- Extramedullary hematopoiesis was diagnosed by immunohistochemistry staining at time interval t 5 in slides from liver isolated during necropsy in mice injected with 4T1-cancer cells. (aging-us.com)
- Hematological studies showed that the infection gave rise to severe anemia, and histopathological investigations in various organs showed multifocal inflammatory infiltrates associated with extramedullary hematopoiesis in the liver, and cerebral edema. (plos.org)
- Increased cell turnover → hyperuricemia Extramedullary hematopoiesis (liver/spleen). (slideshare.net)
- Ectopic extramedullary hematopoiesis most commonly occurs in the liver and spleen but may, in fact, occur almost anywhere in the body. (thejns.org)
- To our knowledge, we report the first case of splenomegaly with extramedullary hematopoiesis in a patient receiving intermittent G-CSF therapy. (annals.org)
- Splenomegaly is often a distinctive feature of myelofibrosis and is due to extramedullary hematopoiesis that can involve and diffusely enlarge almost any organ . (rochester.edu)
- Classic appearances of myelofibrosis include diffuse osteosclerosis, massive splenomegaly, and extramedullary haematopoiesis. (springer.com)
- Myelofibrosis commonly demonstrates well-described characteristic imaging features, namely diffuse osteosclerosis, massive splenomegaly, and extramedullary haematopoiesis (EMH). (springer.com)
- When mice are bred to a germline or a hematopoietic-specific Cre Recombinase expressing strain such as B6.FVB-Tg(EIIa-cre)C5379Lmgd/J (Stock No. 003724 ), B6.Cg-Tg(Mx1-cre)1Cgn/J (Stock No. 003556 ), or VavCre, mice are a model of MPN characterized by elevated hematocrit (HCT), splenomegaly, and prominent splenic extramedullary erythropoiesis. (jax.org)
- This results in extramedullary hematopoiesis with resultant symptomatic and sometimes massive splenomegaly. (fda.gov)
Spinal cord compre3
- Spinal cord compression due to extramedullary hematopoiesis (EMH) is a rare complication of thalassemia and generally presents as paraparesis with sensory impairment. (haematologica.org)
- Extramedullary haematopoiesis (EMH) is a rare cause of spinal cord compression. (journals.co.za)
- Spinal cord compression secondary to extramedullary hematopoiesis in a dog. (nih.gov)
- Extramedullary hematopoiesis, or myeloid metaplasia, is a frequently encountered condition, occurring usually in association with certain types of anemia. (annals.org)
- Splenic macrophages and adhesion molecules may be involved in regulation of extramedullary myeloid cell generation in cardiovascular disease. (wikipedia.org)
- Myelofibrosis with myeloid metaplasia (MMM) is currently classified as a classic (ie, BCR-ABL-negative) myeloproliferative disorder characterized by anemia, multiorgan extramedullary hematopoiesis, constitutional symptoms, and premature death from either leukemic transformation or other disease complications. (nih.gov)
- Adult Cutaneous extramedullary hematopoiesis is a rare cutaneous manifestation of myelofibrosis, where hematopoiesis occurs in the skin rather than the bone marrow, causing polymorphic skin lesions. (visualdx.com)
- While EMH is physiological during fetal development, pathogenic EMH can emanate when physiological haematopoiesis in the bone marrow is ineffective and haematopoietic stem cells migrate to other tissues, as is often seen in disorders of the haematopoietic system, such as thalassemia and myelofibrosis. (bmj.com)
- Myelofibrosis is characterized by fibrotic replacement of the bone marrow as evidenced by increased reticulin staining and it is associated with extramedullary hematopoiesis . (rochester.edu)
- Extramedullary haematopoiesis (EMH) is a compensatory phenomenon in hematological diseases with insufficient blood cell production, either due to a bone marrow replacement disease (e.g. myelofibrosis) or hemolytic anaemia with ineffective erythropoesis (e.g. betathalassaemia, sickle cell anaemia, and hereditary spherocytosis). (biomedcentral.com)
- Our objective was to define the role of combined 99m Tc-sulfur colloid bone marrow (SC BM) scintigraphy, SPECT or SPECT/ CT, and chest CT in diagnosing diffuse pulmonary extramedullary hematopoiesis (PEMH) in patients with myelofibrosis. (uthscsa.edu)
Splenic Extramedullary Hematopoiesis1
- On CT, splenic extramedullary hematopoiesis may appear as multiple hypodense mass lesions. (rochester.edu)
- In comparison to the bone marrow, where trilineage hematopoiesis occurs, the lungs preferentially contribute to the production of platelets through a resident population of megakaryocytes. (wikipedia.org)
- Additional work-up included a bone marrow biopsy that exposed a hypercellular marrow (60 percent) polymorphous trilineage hematopoiesis moderate to severe reticulin fibrosis (grade 2/3) and 1% blasts (Number 2). (ranscombehouseglynde.com)
- AN: Hairy cell leukemia is a rare and incurable malignancy in which malignant "hairy" B-cell lymphocytes accumulate in bone marrow and interfere with trilineage hematopoiesis. (fda.gov)
- Extramedullary erythropoiesis is frequently a response to certain types of anemia (e.g., hemolytic anemia or blood loss) and some situations leading to hypoxia (e.g., respiratory disease). (nih.gov)
- In view of the bilateral adrenal masses, the differential diagnosis considered were tuberculosis, histoplasmosis, lymphoma and the possibility of adrenal extramedullary erythropoiesis. (bmj.com)
- Extramedullary hematopoiesis (EMH) is a compensatory reaction caused by the presence of hematopoietic precursors outside the bone marrow, ineffective erythropoiesis and patients with chronic hemolytic anemia. (annexpublishers.co)
- Extramedullary hematopoiesis (EMH) is a compensatory mechanism that leads to the production of blood cell precursors outside the marrow in patients with ineffective erythropoiesis and chronic hemolytic anemia [ 1 ]. (annexpublishers.co)
- Extramedullary hematopoiesis should be considered in the differential diagnosis in a patient with chronic severe anemia and a paraspinal mass. (appliedradiology.com)
- An intracranial extramedullary hematopoiesis, although extremely rare, should be considered as a potential ancillary diagnosis in any thalassemic patient and therefore appropriate studies should be performed to investigate the probable intracranial ectopic marrow before any surgical intervention. (biomedcentral.com)
- CT scanning is rarely of value, yet it may define the anatomy of change in complex bones and confirm the diagnosis of extramedullary hematopoiesis. (medscape.com)
- We present an unusual case of an intracranial extramedullary hematopoiesis with a choroid plexus origin in a 34-year-old Caucasian man with beta thalassemia intermedia, who presented with the complaints of chronic headache and rapid progressive visual loss. (biomedcentral.com)
- The authors report two cases of intracranial extramedullary hematopoiesis in beta thalassemia. (springer.com)
- Intracranial extramedullary hematopoiesis in beta-thalassemia. (springer.com)
- Karimi M, Cohan N, Pishdad P. Hydroxyurea as a first-line treatment of extramedullary hematopoiesis in patients with beta thalassemia: four case reports. (springer.com)
- Extramedullary hematopoiesis (EMH or sometimes EH) refers to hematopoiesis occurring outside of the medulla of the bone (bone marrow). (wikipedia.org)
- Pathologic EMH can occur during adulthood when physiologic hematopoiesis can't work properly in the bone marrow and the hematopoietic stem cells (HSC) have to migrate to other tissues in order to continue with the formation of blood cellular components. (wikipedia.org)
- In adults, the majority of hematopoiesis occurs in the bone marrow. (wikipedia.org)
- Extramedullary hematopoiesis is the production of blood elements outside the bone marrow cavity. (appliedradiology.com)
- Thereafter, the bone marrow is the primary site of hematopoiesis. (appliedradiology.com)
- Extramedullary hematopoiesis occurs as a compensatory mechanism for abnormal hematopoiesis when normal red marrow is unable to function because of deficiency disorders or because of various pluripotent stem cell disorders. (appliedradiology.com)
- One of the most popular hypothesesis that EMH is a physiologic, compensatory mechanism for unstable bone marrow hematopoiesis. (appliedradiology.com)
- Cyp27a1-deficient mice had significantly reduced 27HC levels, HSC mobilization, and EMH during pregnancy but normal bone marrow hematopoiesis and EMH in response to bleeding or G-CSF treatment. (jci.org)
- The CT features were typical of extramedullary haematopoiesis (EMH), defined as the development and growth of haematopoietic tissue outside the bone marrow. (thefreelibrary.com)
- It is particularly prone to occur with anemia due to myelophthisis or myelosclerosis, and is usually thought of as a compensatory mechanism whereby extramedullary tissue attempts to compensate for a deficiency of the marrow. (annals.org)
- However, extramedullary hematopoiesis is found often in autopsy material from cases in which there is no detectable bone marrow deficiency. (annals.org)
- Extramedullary haematopoiesis (EMH) is the formation of cellular components of blood, occurring outside of the bone marrow. (bmj.com)
- A 99m Tc bone marrow scan demonstrated increased tracer activity throughout both lungs, an outcome consistent with extramedullary hematopoiesis. (elsevier.com)
- Dysregulated hematopoiesis occurs in several chronic inflammatory diseases, but it remains unclear how hematopoietic stem cells (HSCs) in the bone marrow (BM) sense peripheral inflammation and contribute to tissue damage in arthritis. (nature.com)
- In children, haematopoiesis occurs in the marrow of the long bones such as the femur and tibia. (thefullwiki.org)
- For the stem cells and other undifferentiated blood cells in the bone marrow, the determination is generally explained by the determinism theory of haematopoiesis, saying that colony stimulating factors and other factors of the haematopoietic microenvironment determine the cells to follow a certain path of cell differentiation. (thefullwiki.org)
- Development and growth of hematopoietic tissue outside of the bone marrow is termed extramedullary hematopoiesis (EMH). (fujita-hu.ac.jp)
- Extramedullary hematopoiesis (EMH) is a normal response to failure of hematopoiesis at its normal site i.e ., bone marrow. (springer.com)
- Ectopic extramedullary hematopoiesis (EMH), defined as the formation of blood cells outside the bone marrow, usually occurs in a scenario of chronic anemia when, even after conversion of the bony yellow marrow to red marrow, the body is still unable to meet the demand for red blood cells. (thejns.org)
- Finally, mice transgenic for IL-4 production developed tissue macrophage accumulation, disruption of splenic architecture, bone marrow hypocellularity, and extramedullary hematopoiesis. (bloodjournal.org)
- Bone marrow failure and extramedullary hematopoiesis in McCune-Albright syndrome. (nih.gov)
- Intracranial deposits of extramedullary hematopoiesis are an extremely rare compensatory process in intermediate and severe thalassemia. (biomedcentral.com)
- Intracranial extramedullary hematopoiesis: brief review of response to radiation therapy. (springer.com)
- Intracranial extramedullary hematopoiesis: MR findings with pathologic correlation. (springer.com)
- Intrathoracic extramedullary hematopoiesis resembling posterior mediastinal tumor. (appliedradiology.com)
- An interesting presentation of intrathoracic extramedullary hematopoiesis In a patient with thalassemia intermedia. (appliedradiology.com)
- The authors report a case of extramedullary haematopoiesis (EMH) presenting as an intrathoracic tumour in a patient with alpha-thalassaemia. (biomedcentral.com)
- Extramedullary myelopoiesis is usually secondary to various inflammatory or immune responses and is a reaction to the need for additional white blood cells. (nih.gov)
- Furthermore, we show that GM-CSF promotes extramedullary myelopoiesis, tissue-toxic neutrophil accumulation in target organs, and GM-CSF prophylactic or therapeutic blockade substantially decreases SpA severity. (nature.com)
- Extramedullary hematopoiesis and myelopoiesis may supply leukocytes in cardiovascular disease and inflammation during adulthood. (wikipedia.org)
- 1 Extramedullary hematopoiesis occurs in severe chronic anemia, which can arise from deficiency disorders such as vitamin B 12 or folate deficiency 2 or from disorders affecting pluripotent stem cells. (appliedradiology.com)
- While there are numerous reports of patients with hereditary spherocytosis developing extramedullary hematopoiesis in the posterior mediastinum, involvement in the paranasal sinuses has not previously been described. (elsevier.com)
- Here, we present the first case of a patient with hereditary spherocytosis developing extramedullary hematopoiesis in the sphenoid sinus. (elsevier.com)
- Extramedullary haematopoiesis: an uncommon posterior mediastinal mass. (thefreelibrary.com)
- A posterior intraspinal extradural mass lesion compressing the spinal cord at the level of thoracic T5-8 was present, suggesting an extramedullary hematopoietic centre, compressing the spinal cord. (mattioli1885journals.com)
- Acute respiratory failure due to extra-medullary hematopoiesis.Chest.1995;108:1170-1172. (appliedradiology.com)
- Of note, cutaneous extramedullary hematopoiesis is a normal occurrence during early embryogenesis, and it occurs until about the fifth month of gestation. (visualdx.com)
- Cutaneous extramedullary hematopoiesis in pre-term or full-term neonates is thought to be an accentuation of a normal physiologic process. (visualdx.com)
- Multiple reports suggest also that cutaneous extramedullary hematopoiesis in neonates may be precipitated by congenital infections, erythroblastosis fetalis, and twin transfusion syndrome. (visualdx.com)
- IMSEAR at SEARO: Extramedullary hematopoiesis of cranial dura mater and choroid plexus and terminal convulsions in a patient with thalassemia-hemoglobin E disease. (who.int)
- Dhechakaisaya S, Shuangshoti S, Susakares A. Extramedullary hematopoiesis of cranial dura mater and choroid plexus and terminal convulsions in a patient with thalassemia-hemoglobin E disease. (who.int)
- If the loss of RBCs becomes severe, hematopoiesis will occur in the extramedullary spaces outside the bone. (wikipedia.org)
- Extramedullary hematopoiesis (EMH) can occur in various tissues, including the adrenal cortex and medulla. (nih.gov)
- In some vertebrates , haematopoiesis can occur wherever there is a loose stroma of connective tissue and slow blood supply, such as the gut , spleen , kidney or ovaries . (thefullwiki.org)
- Emamhadi M, Alizadeh A. Effect of hypertransfusion on extramedullary hematopoietic compression mass in thalassemia major: a case report. (springer.com)
- CT and MR findings in extramedullary haematopoiesis with biliary system encasement: a case report. (semanticscholar.org)
- Definitive hematopoiesis differs from the primitive phase through the production of hematopoietic stem cells. (wikipedia.org)
- We report the unique association of Masson s pseudoangiosarcoma (endothelial papillary hyperplasia) and extramedullary hematopoiesis. (isciii.es)
- Sauer B, Buy X, Gangi A, Roy C. Exceptional localization of extramedullary hematopoiesis: presacral and periureteral masses. (springer.com)
- Extramedullary hematopoiesis (EMH) occurs commonly in patients with severe thalassemia who receive inadequate treatment. (biomedcentral.com)
- Intraoperative photo showing a well-demarcated, dark-coloured mass (* = extramedullary haematopoietic tumour). (biomedcentral.com)
- MR of thoracic cord compression caused by epidural extramedullary hematopoiesis in myelodysplastic syndrome. (semanticscholar.org)
- The present case is one of the largest umbilical cord hemangiomas reported in the literature, and the first hemangioma case with MS-hCG elevation, extramedullary hematopoiesis, and positive AFP staining in the cord hemangioma. (biomedcentral.com)