Spinal Cord Compression
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
Motor Neuron Disease
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
Nerve Compression Syndromes
Anemia, Sickle Cell
The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
Hemoglobin SC Disease
Patient Care Team
Leukemia-Lymphoma, Adult T-Cell
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Catheterization, Central Venous
Hematopoietic Stem Cell Transplantation
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Bone Marrow Transplantation
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Dose-Response Relationship, Radiation
The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
Devices containing fissionable material in sufficient quantity and so arranged as to be capable of maintaining a controlled, self-sustaining NUCLEAR FISSION chain reaction. They are also known as atomic piles, atomic reactors, fission reactors, and nuclear piles, although such names are deprecated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Hematological cancers. Rituximab is used to treat cancers of the white blood system such as leukemias and lymphomas, ...
Haematological. Haematological examinations involve examining the blood of animals to determine the presence of parasites ...
Hematological findings. The blood film can point towards vitamin deficiency: *Decreased red blood cell (RBC) count and ...
Hematological. Main article: Hematopathology. Clinical chemistry: an automated blood chemistry analyzer ...
Hematological. Pallor, petechiae, bleeding diathesis. Behavior. Lethargic, apathetic. Source: "Protein Energy Malnutrition" ...
Hematological response rates to the dexamethasone/melphalan regimens have been reported to be in the 80% range with ... Hematological Oncology. doi:10.1002/hon.2417. PMID 28397326. Lam C, Margolin E (2016). "A case of POEMS and chronic papilledema ...
Hematological dysfunction of paraneoplastic syndromes can be seen from an increase of erythropoietin (EPO), which may occur in ... Staszewski H (1997). "Hematological paraneoplastic syndromes". Semin. Oncol. 24 (3): 329-33. PMID 9208888. Zadik Y, Nitzan DW ( ... and hematological. The most common presentation is a fever (release of endogenous pyrogens often related to lymphokines or ... The following diseases manifest by means of hematological dysfunction: granulocytosis, polycythemia, Trousseau sign, ...
Other hematological agents. Antianemic. preparations. (B03). Erythropoietins. *Darbepoetin alfa. *Methoxy polyethylene glycol- ...
Other hematological agents. Antianemic. preparations. (B03). Erythropoietins. *Darbepoetin alfa. *Methoxy polyethylene glycol- ...
Primary effusion lymphoma
Hematological Oncology. 35 (4): 878-883. doi:10.1002/hon.2372. PMID 27859456. S2CID 21614181. Zanelli M, Zizzo M, Bisagni A, ...
Digital polymerase chain reaction
Hematological Oncology. 36 (2): 429-435. doi:10.1002/hon.2489. PMID 29210102. S2CID 4968214. Paxton, Anne (Oct 2017). "Revived ...
Stem cell marker
Reid CD (June 1987). "The significance of endogenous erythroid colonies (EEC) in haematological disorders". Blood Reviews. 1 (2 ... 1984). "Bone marrow monosomy 7: hematologic and clinical manifestations in childhood and adolescence". Hematological Oncology. ...
Woessmann W, Quintanilla-Martinez L (June 2019). "Rare mature B-cell lymphomas in children and adolescents". Hematological ... December 2017). "Follicular lymphoma: State-of-the-art ICML workshop in Lugano 2015". Hematological Oncology. 35 (4): 397-407. ...
Niu H (December 2002). "The proto-oncogene BCL-6 in normal and malignant B cell development". Hematological Oncology. 20 (4): ...
Hematological Oncology. 34 (2): 69-78. doi:10.1002/hon.2292. PMID 27018197. "Leukostasis". Medical Subject Headings, 2009-2009- ... of coagulopathy in patients with acute leukemia is much more often than in patients with chronic malignant hematological ...
Indolent T cell lymphoproliferative disorder of the gastrointestinal tract
Hematological Oncology. 35 (1): 3-16. doi:10.1002/hon.2317. PMID 27353398. Ganapathi KA, Pittaluga S, Odejide OO, Freedman AS, ...
Hematological Oncology. 31 (1): 1-9. doi:10.1002/hon.2017. PMID 22674797. S2CID 205914765. Ito, Daisuke; Frantz, Aric M.; ...
Hematological Oncology. 26 (4): 241-246. doi:10.1002/hon.867. ISSN 1099-1069. PMC 3496178. PMID 18613223. Alkjaersig N, ...
Enteropathy-associated T-cell lymphoma
Hematological Oncology. 35 (1): 3-16. doi:10.1002/hon.2317. PMID 27353398. S2CID 21364706. Lemonnier F, Gaulard P, de Leval L ( ...
Hematological Oncology. 30 (4): 190-3. doi:10.1002/hon.1023. PMID 22246856. S2CID 204843221. Palomaki GE, McClain MR, Melillo S ...
Pediatric-type follicular lymphoma
Woessmann W, Quintanilla-Martinez L (June 2019). "Rare mature B-cell lymphomas in children and adolescents". Hematological ...
Hematological Oncology. 37 Suppl 1: 53-61. doi:10.1002/hon.2585. PMID 31187530. Gupta S, Jiang M, Anthony A, Pernis AB ( ...
Marginal zone B-cell lymphoma
In a small number of cases, the disease has an increased frequency in patients who have a family history of a hematological ... Kempf W, Zimmermann AK, Mitteldorf C (June 2019). "Cutaneous lymphomas-An update 2019". Hematological Oncology. 37 Suppl 1: 43- ... Woessmann W, Quintanilla-Martinez L (June 2019). "Rare mature B-cell lymphomas in children and adolescents". Hematological ... Hematological Oncology. 36 (2): 457-462. doi:10.1002/hon.2498. PMID 29469175. Dasanu CA, Bockorny B, Grabska J, Codreanu I ( ...
Natural killer cell enteropathy
Hematological Oncology. 35 (1): 3-16. doi:10.1002/hon.2317. PMID 27353398. Ganapathi KA, Pittaluga S, Odejide OO, Freedman AS, ...
Hematological Oncology. 26 (3): 167-70. doi:10.1002/hon.855. PMID 18381689. S2CID 20572446. Cooper K, Leong AS (2003). Manual ...
Chronic multifocal Langerhans cell histiocytosis
Langerhans Cell Histiocytosis". In Stephen M. Ansell (ed.). Rare Hematological Malignancies. Springer Science & Business Media ...
Mast cell sarcoma
2008). Rare Hematological Malignancies. Cancer Treatment & Research. Springer. v t e. ...
synd/2799 at Who Named It?, Ansell, Stephen M. (1 January 2008). Rare Hematological Malignancies. Springer Science+Business ...
Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight...
Venetoclax: Targeting BCL2 in Hematological Cancers | SpringerLink
... anti-cancer therapy with small-molecule inhibitors and antibodies moved to the forefront as a strategy to treat hematological ... Scheffold A., Jebaraj B.M.C., Stilgenbauer S. (2018) Venetoclax: Targeting BCL2 in Hematological Cancers. In: Martens U. (eds) ... anti-cancer therapy with small-molecule inhibitors and antibodies moved to the forefront as a strategy to treat hematological ...
Hepatic Manifestations in Hematological Disorders
Oncolytic Virotherapy for Hematological Malignancies
2. Treatment of Hematological Malignancies. The cornerstone of conventional therapy for hematological malignancies includes ... 1. Hematological Malignancies Hematological malignancies include leukemias, lymphomas, multiple myeloma (MM), and the ... Oncolytic Virotherapy for Hematological Malignancies. Swarna Bais,1 Eric Bartee,2 Masmudur M. Rahman,2 Grant McFadden,2 and ... The causes of hematological cancers vary depending on the specific malignancy. Exposure to environmental toxins such as ...
The Heme Oxygenase System in Hematological Malignancies. - PubMed - NCBI
The Heme Oxygenase System in Hematological Malignancies.. Li Volti G1,2, Tibullo D3, Vanella L4, Giallongo C3, Di Raimondo F3, ... Furthermore, some hematological malignancies (e.g., chronic myeloid leukemia and multiple myeloma) have served to explore the ... The HO system may serve as an important tool in the field of hematological malignancies because it can be exploited to ... This review focuses on the role of HO-1 in various hematological malignancies and the possibility of exploiting such targets to ...
Hematological dictionary definition | hematological defined
... comparative more hematological, superlative most hematological) 1. hematologicOrigin hematologic + -al... ... "hematological." YourDictionary, n.d. Web. 13 December 2018. ,https://www.yourdictionary.com/hematological,. ... hematological. (n.d.). Retrieved December 13th, 2018, from https://www.yourdictionary.com/hematological ...
Hematological Oncology | IntechOpen
Haematological reference values - Oxford Reference
Access to the complete content on Oxford Reference requires a subscription or purchase. Public users are able to search the site and view the abstracts and keywords for each book and chapter without a subscription.. Please subscribe or login to access full text content.. If you have purchased a print title that contains an access token, please see the token for information about how to register your code.. For questions on access or troubleshooting, please check our FAQs, and if you cant find the answer there, please contact us.. ...
Haematological Localisation | SpringerLink
There are no haematological findings that are specific or characteristic or could be used to diagnose brucellosis. The most ... There are no haematological findings that are specific or characteristic or could be used to diagnose brucellosis. The most ... Crosby, E., Llosa, I, Quesada, M. and Carrillo, P. (1984) Haematological changes in brucellosis. J. Infect. Dis., 150, 419-424. ... Al-Nozha, M. M. (1987) A case of pancytopenia in acute brucellosis with review of haematological abnormalities. Ann. Saudi Med. ...
Several haematological disorders are now routinely treated in outpatient clinics with aggressive chemotherapy, so some patients ... This may be caused by several haematological conditions. Blood viscosity is a function of the concentration and composition of ... Patients with both malignant and non-malignant haematological disease may present with dramatic and often life threatening ... Patients with a variety of haematological diseases are immunocompromised due to either their underlying disease or the ...
Epigenetic inhibitors in hematological malignancies
... discussed novel ways to specifically target epigenetic alterations in hematological malignancies. Epigenetic alterations do not ... Epigenetic inhibitors in hematological malignancies. Jul 19 2018 In a Hematology-in-Focus session Professor Brian Huntly ( ... Genes involved in DNA (de)methylation, such as DNMT3A, TET2, and IDH1/2, are often mutated in hematological malignancies. ... University of Cambridge, UK) discussed novel ways to specifically target epigenetic alterations in hematological malignancies. ...
MORTALITY IN CAPTIVE BIGHORN SHEEP - CLINICAL, HEMATOLOGICAL, AND PATHOLOGICAL OBSERVATIONS
Hematological changes indicated the chronicity of the disease and had prognostic and limited diagnostic value. Amyloidosis was ... ALAN WOOLF and DAVID C. KRADEL "MORTALITY IN CAPTIVE BIGHORN SHEEP - CLINICAL, HEMATOLOGICAL, AND PATHOLOGICAL OBSERVATIONS," ... ALAN WOOLF, DAVID C. KRADEL "MORTALITY IN CAPTIVE BIGHORN SHEEP - CLINICAL, HEMATOLOGICAL, AND PATHOLOGICAL OBSERVATIONS," ...
Recommendations | Haematological cancers: improving outcomes | Guidance | NICE
... staffing and care for people with haematological cancer ... 1.3.3 Every patient with any form of haematological cancer (as ... All core members should have a special interest in haematological cancer and attend MDT meetings as part of their regular work ... 1.2.3 Inpatient isolation facilities for adults and young people who have haematological malignancies and are at risk of more ... 1.2.13 Consider ambulatory care for adults and young people who have haematological malignancies that are in remission and who ...
Haematological manifestations of ... preview & related info | Mendeley
Hematological Diagnosis of Sickle Cell Anemia | SBIR.gov
Sickle cell anemia is an inherited disorder of erythrocytes characterized by chronic anemia, recurrent pain, susceptibility to infections, chronic and recurrent organ dysfunction, and diminished life-expectancy. Even among patients having documented homozygous sickle cell anemia (Hb SS), there exists an astonishing degree of variability in clinical severity. Some die from strokes as young children, others live well into their seventies. Some seek medical attention for pain weekly, others go years without pain. The absolute nature of current therapeutic measures for sickle cell disease (SCD), e. g. termination of pregnancy and bone marrow transplantation (BMT), emphasizes the importance of pretherapeutic predictions of mild and severe disease before the nature of the disease has been declared. In this regard, we propose to use polymerase chain reaction (PCR)-based methods to detect sequence variations that are related to disease severity - alpha-globin genotypes, beta-cluster restriction fragment ...
Hematological (Leukemia/Lymphoma) Cancers | Meridian Health
Stem Cell Transplantation for Hematological Malignancies - Full Text View - ClinicalTrials.gov
Angiogenesis and Anti-Angiogenesis in Hematological Malignancies by Domenico Ribatti | Waterstones
Buy Angiogenesis and Anti-Angiogenesis in Hematological Malignancies by Domenico Ribatti from Waterstones today! Click and ... Angiogenesis and Anti-Angiogenesis in Hematological Malignancies (Paperback). Domenico Ribatti (author) Sign in to write a ... It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and ... modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the ...
Hematological Malignancies | Norton Healthcare
PRIME PubMed | Hematological findings and complications of COVID-19
Hematological findings and complications of COVID-19. Download Prime PubMed App to iPhone, iPad, or Android ... "Hematological Findings and Complications of COVID-19." American Journal of Hematology, vol. 95, no. 7, 2020, pp. 834-847. ... Hematological Findings and Complications of COVID-19. Am J Hematol. 2020;95(7):834-847. PubMed PMID: 32282949. ... Hematological findings and complications of COVID-19.. Am J Hematol. 2020 07; 95(7):834-847.AJ ...
Frontiers | Natural Killer Cells Modulation in Hematological Malignancies | Immunology
We present here various mechanisms involved in the escape of hematological malignancies from NK cells surveillance, i.e. NK ... We present here various mechanisms involved in the escape of hematological malignancies from NK cells surveillance, i.e. NK ... Abnormal NK cytolytic functions have been described in many hematological malignancies. ... Abnormal NK cytolytic functions have been described in many hematological malignancies. ...
Hematological Cancer Research Investment and Education Act - Wikipedia
PhD scholarship in Haematological Cancer Bioinformatics
Haematological Cancers Workshop | Cancer Council Victoria
Leukaemia and Other Haematological Cancers workshop for health professionals, held at Peter MacCallum Cancer Centre on 4 August ... Lymphomas, leukaemia & other haematological cancers Download PowerPoint presentations from the Lymphomas, leukaemia and other ... He has been involved for many years in the treatment of patients with a whole range of haematological cancers. His main ... Michael Dickinson is a haematologist with a passion for the early phase clinical trials for haematological malignancies. He is ...
NIOSHTIC-2 Publications Search - 20040321 - Hematological effects of long-term radiation exposure in Russian nuclear workers.
This book covers the following: INTRODUCTION, GENERAL FRAMEWORK, LITERATURE REVIEW: radiation dose-response models, radiation effects at chromosomal and cellular level, radiosensitivity of the hematopoietic system, mayak product association, previous studies of long term occupational radiation exposure, sex related differences in radiosensitivity; Review of Repeated Measures Analysis Techniques: u
Monoclonal antibodies in hematological malignancies
The present review sets out their application in hematological diseases.. Key words:. monoclonal antibodies, hematological ... Monoclonal antibodies in hematological malignancies. Rev Hematol Mex 2017; 18 (1) Language: Espa ol. References: 35. Page: 16- ... Monoclonal antibodies are a successful therapeutic choice for a wide range of diseases, including hematological malignancies. ...
Clonal evolution in hematological malignancies and therapeutic implications
Clostridium difficile in haematological malignancy.
Peripheral T-cell lymphoma gene expression profiles - Martinez-Delgado - 2006 - Hematological Oncology - Wiley Online Library
Hematological (Blood Forming) | Health Effects of Exposure to Substances and Carcinogens | Toxic Substance Portal | ATSDR
MalignanciesMalignancyPatientsManifestationsThreatening complicationsTargetsCancers Therapeutics MarketCardiovascularLymphomasAlterationsTherapeuticsLymphomaParametersComplications of HIV infectionOncologyToxicityBone marrowNeoplasmsInfectionDiseasesDiagnosisCancerAnalyses includedStudyPhysiologicalTreatmentConclusionsEvaluateApoptosisGeneticMolecular
- This book presents a general introduction to and review of HIV-associated hematological malignancies, with a special focus on practical management issues. (springer.com)
- Nevertheless, optimal treatment of hematological malignancies remains a challenge, particularly in patients with severe immunosuppression. (springer.com)
- Hematological malignancies such as leukemias, lymphomas, multiple myeloma (MM), and the myelodysplastic syndromes (MDSs) primarily affect adults and are difficult to treat. (hindawi.com)
- Hematological malignancies include leukemias, lymphomas, multiple myeloma (MM), and the myelodysplastic syndromes (MDSs) that most often affect individuals older than 60 years of age. (hindawi.com)
- Exposure to environmental toxins such as benzenes, prior cytotoxic treatment such as radiotherapy or chemotherapy for an antecedent cancer, as well as infections have all been implicated as causative factors in initiating hematological malignancies. (hindawi.com)
- In contrast, recurrent cytogenetic abnormalities have also been observed in hematological malignancies. (hindawi.com)
- Based on the utility of genetic information in determining prognosis and type of treatment in hematological malignancies, increased attention has been given to fully assessing the blood cancer genome. (hindawi.com)
- The Heme Oxygenase System in Hematological Malignancies. (nih.gov)
- Several lines of evidence suggest that hematological malignancies exhibit an altered redox balance homeostasis that can lead to the activation of various survival pathways that, in turn, lead to the progression of disease and chemoresistance. (nih.gov)
- This review focuses on the role of HO-1 in various hematological malignancies and the possibility of exploiting such targets to improve the outcome of well-established chemotherapeutic regimens. (nih.gov)
- Furthermore, some hematological malignancies (e.g., chronic myeloid leukemia and multiple myeloma) have served to explore the non-canonical functions of HO-1, such as the association between nuclear compartmentalization and genetic instability and/or chemoresistance. (nih.gov)
- The HO system may serve as an important tool in the field of hematological malignancies because it can be exploited to counteract chemoresistance and to monitor the outcome of bone marrow transplants and may be an additional target for combined therapies. (nih.gov)
- In a Hematology-in-Focus session Professor Brian Huntly (University of Cambridge, UK) discussed novel ways to specifically target epigenetic alterations in hematological malignancies. (ehaweb.org)
- Genes involved in DNA (de)methylation, such as DNMT3A, TET2, and IDH1/2 , are often mutated in hematological malignancies. (ehaweb.org)
- Number of participants with long-term disease free survival after being treated with busulfan (BU), cyclophosphamide (CY) and melphalan (L-PAM) followed by HCT for hematological malignancies. (clinicaltrials.gov)
- Number of participants with chronic GVHD after being treated with busulfan (BU), cyclophosphamide (CY) and melphalan (L-PAM) followed by HCT for hematological malignancies. (clinicaltrials.gov)
- Number of participants with regimen-related toxicity 100 days post transplant after being treated with busulfan (BU), cyclophosphamide (CY) and melphalan (L-PAM) followed by HCT for hematological malignancies. (clinicaltrials.gov)
- It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. (waterstones.com)
- More recently, it has been emphasized the pro-angiogenic role of the so called "vascular niche", indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies. (waterstones.com)
- It will be most helpful for researchers looking for information on the subject, but it also enlightens practitioners on the mechanisms of action of some common treatments for hematological malignancies. (waterstones.com)
- Hematological malignancies (HM) treatment improved over the last years resulting in increased achievement of complete or partial remission, but unfortunately high relapse rates are still observed, due to remaining minimal residual disease. (frontiersin.org)
- Michael Dickinson is a haematologist with a passion for the early phase clinical trials for haematological malignancies. (cancervic.org.au)
- Monoclonal antibodies are a successful therapeutic choice for a wide range of diseases, including hematological malignancies. (medigraphic.com)
- Altogether, these studies reveal the complex evolutionary trajectories occurring across individual hematological malignancies. (nih.gov)
- Twenty patients with haematological malignancies who developed Clostridium difficile bowel infection or colonisation are described. (biomedsearch.com)
- In parallel to our ongoing clinical trial of the TCR-T therapy MDG1011 in patients suffering from acute myeloid leukemia or myelodysplastic syndrome, this study is an important step for Medigene in our program for hematological malignancies towards delivering safe and efficacious T cell-based cancer immunotherapies to patients and physicians. (yahoo.com)
- This study is evaluating the safety, pharmacokinetic profile and efficacy of venetoclax under a once daily dosing schedule in Japanese participants with hematological malignancies. (clinicaltrials.gov)
- Patients with hematological malignancies are prone to infections due to defects in their immune system. (cochrane.org)
- We conducted a systematic review assessing the role of administration of immunoglobulins from healthy donors as prophylaxis in patients with hematological malignancies. (cochrane.org)
- To determine whether prophylaxis with IVIG reduces mortality or affects other outcomes in patients with hematological malignancies. (cochrane.org)
- Raanani P, Gafter-Gvili A, Paul M, Ben-Bassat I, Leibovici L, Shpilberg O. Immunoglobulin prophylaxis in hematological malignancies and hematopoietic stem cell transplantation. (cochrane.org)
- This] study provides new insights into the pathobiology of MDS and paves the way for increased use of artificial intelligence for the assessment and diagnosis of hematological malignancies," says PhD Olivier Elemento from the Caryl and Israel Englander Institute for Precision Medicine in his commentary to the article in Blood Cancer Discovery, a journal of the American Association for Cancer Research. (eurekalert.org)
- Unmet needs across the hematological malignancies remain high, with most traditional therapies conferring low levels of specificity and high toxicity. (marketresearch.com)
- This paper reports on an analysis of nearly 27,000 hematological malignancies diagnosed in the U.K. in the 10-year period 1984 to 1993. (nih.gov)
- Patients with hematological malignancies (HM) often have respiratory comorbidities (RCs) such as respiratory infection, complications, and abnormal findings in radiological study in a hospital setting. (ersjournals.com)
- Hematological malignancies are a class of cancer that affect the blood, lymph nodes and bone marrow, and include numerous forms of leukemia, lymphoma and myeloma. (pitchengine.com)
- Hematological malignancies constituted 9% of all newly diagnosed malignancies in the US in 2011, with data indicating that lymphomas are more prevalent than leukemia or myeloma. (pitchengine.com)
- Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. (nature.com)
- In the various cell lines examined, this abnormality was determined in only one derived from AML and never found in other hematological malignancies. (nature.com)
- Hematological malignancies (HM) are a collection of malignant transformations originating from cells in the primary or secondary lymphoid organs. (ovid.com)
- Hematological malignancies are known to have a multitude of aberrations across the genome, including fusion genes, somatic mutations such as single nucleotide variants (SNVs) and insertions/deletions (indels), and copy number variations (CNVs) such as duplications, deletions, loss of heterozygosity (LOH), copy neutral LOH (cnLOH), ploidy, and more. (thermofisher.com)
- This review provides an overview of the current scenario, with a focus on prevention of infection in patients with hematological malignancies and the role of Ig replacement therapy. (frontiersin.org)
- Landmark clinical trials in CLL and MM in the late 1980s and early 1990s settled the basis for the current indications of intravenous immunoglobulins (IVIg) in hematological malignancies associated with severe secondary hypogammaglobulinemia and recurrent infections ( 4 - 6 ). (frontiersin.org)
- First, we briefly review the current evidence for the immunological approach to the prevention of infectious complications associated with defective antibody responses in CLL and MM. We then survey the current challenges derived from the improvements in diagnosis and therapy of hematological malignancies and discuss some practical issues. (frontiersin.org)
- Candida inconspicua was recovered from three patients with hematological malignancies. (asm.org)
- Fungal infections are an increasing cause of morbidity and mortality in patients with hematological malignancies ( 4 ). (asm.org)
- Angiopoietins in haematopoietic stem cell mobilisation in patients with haematological malignancies. (sigmaaldrich.com)
- TET2, the second member of TET protein family, is frequently mutated in patients with hematological malignancies, leading to aberrant DNA methylation profiling and decreased 5hmC levels. (pubmedcentralcanada.ca)
- Here, we review recent literature on TET2 interactors and discuss their possible roles in TET2 loss-mediated dysregulation of hematopoiesis and pathogenesis of hematological malignancies. (pubmedcentralcanada.ca)
- We also discuss the contribution of these TET2 interactors to TET2 loss-mediated hematological malignancies. (pubmedcentralcanada.ca)
- The diagnosis and monitoring of hematological malignancies is complex and requires a systematic approach. (wisepress.com)
- Diagnostic Techniques in Hematological Malignancies details the principles and applications of each of these test types in the diagnosis of hematological malignancies in blood and bone marrow. (wisepress.com)
- The second section focuses on the clinical entities, detailing the most appropriate tests for diagnosis, staging and monitoring of different hematological malignancies and includes test utilization to identify prognostic markers and potential therapeutic targets. (wisepress.com)
- It's a practical and useful guide, providing a rational and structured approach to the laboratory assessment of hematological malignancies. (wisepress.com)
- Immunotherapy is an attractive therapeutic option for patients with haematological malignancies. (ovid.com)
- Until recently, the progress in the development of tumour vaccines for haematological malignancies had been slow due to the lack of suitable targets. (ovid.com)
- Cancer-testis (CT) antigens are potentially suitable molecules for tumour vaccines of haematological malignancies because of their high immunogenicity in vivo and their relatively restricted normal tissue distribution. (ovid.com)
- We discuss the expression of CT antigens in patient with haematological malignancies and provide evidence in support of their immunogenicity in vivo in these patients. (ovid.com)
- We also address the role of 'epigenetic' regulation of CT antigens in haematological malignancies and how hypomethylating agents could induce the expression of some of these antigens in tumour cells to overcome the problem of heterogeneity of expression of the antigen within individual tumour specimens. (ovid.com)
- Finally, we discuss the direction of future research in advancing the development of tumour vaccines for haematological malignancies. (ovid.com)
- Many patients with hematological malignancies potentially curable by bone marrow transplantation are not considered for transplantation because an HLA identical family or unrelated donor is unavailable. (knowcancer.com)
- This protocol evaluates a new preparative regimen designed to ensure stem cell engraftment by increased immunosuppression, followed by a G-CSF mobilized T cell depleted, stem cell rich, peripheral blood progenitor cell (PBPC) transplant from a mismatched related donor in patients with high risk hematological malignancies. (knowcancer.com)
- Out of 54 cases, there were 16 cases (29.60%) of hypoplastic bone marrow, 15 cases (27.78%) of hematological malignancies, 13 cases (24.10%) of megaloblastic anemia, 4 cases (11.11%) of erythroid hyperplasia and 6 cases (7.41%) of normcellular bone marrow. (nepjol.info)
- The commonest cause of pancytopenia in our study was hypoplastic bone marrow followed by hematological malignancies and megaloblastic anemia. (nepjol.info)
- CD19 is an ideal target with great potential for treating B-cell-derived hematological malignancies. (centerwatch.com)
- STOCKHOLM, Sweden, Nov. 21, 2018 /PRNewswire/ -- Medivir AB (Nasdaq Stockholm: MVIR) today announces that MIV-828 has been nominated as a candidate drug (CD) for the treatment of acute myeloid leukemia (AML) and other hematological malignancies. (pharmiweb.com)
- MIV-828 is a nucleotide prodrug that has been optimised for the treatment of AML and other hematological malignancies such a myelodysplastic syndrome and T-cell lymphoma. (pharmiweb.com)
- The causes of hematological cancers vary depending on the specific malignancy. (hindawi.com)
- 1.1.1 Take into account that recommendations 1.1.2 to 1.1.4 are most likely to be achieved if the component parts of the specialist integrated haematological malignancy diagnostic services (SIHMDS) are located at a single site. (nice.org.uk)
- NEW YORK (GenomeWeb) - 14M Genomics today announced a collaboration with the Haematological Malignancy Research Network aimed at improving diagnosis and clinical care for patients with blood and lymphatic cancers. (genomeweb.com)
- Clostridium difficile in haematological malignancy. (biomedsearch.com)
- Yet no one technology can efficiently assess all of these aberration types, making the profiling of hematological malignancy samples time and labor intensive. (thermofisher.com)
- When used together, these proven technologies enable comprehensive, cost-effective analysis for hematological malignancy samples, with results in a single report. (thermofisher.com)
- While the detection of global CNVs or the screening of somatic mutations and fusion genes using a single panel are game changers for comprehensive, accurate profiling of hematological malignancy samples, some labs may not have the necessary equipment or expertise to perform such assays or may require result confirmation by an orthogonal technique. (thermofisher.com)
- Patients affected by hematological malignancy, in particular chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), were recognized as presenting antibody production deficits many years ago ( 1 , 2 ), and the proposal was made that they might benefit from antibody replacement therapy ( 3 ). (frontiersin.org)
- This restricts the use of mismatched transplants to patients less than 45 years at high risk of dying from the hematological malignancy. (knowcancer.com)
- Acute myeloid leukemia was the commonest hematological malignancy. (nepjol.info)
- Patients with both malignant and non-malignant haematological disease may present with dramatic and often life threatening complications of their diseases. (bmj.com)
- He has been involved for many years in the treatment of patients with a whole range of haematological cancers. (cancervic.org.au)
- Apart from his appointment at the Peter Mac, Max runs a private practice in Cabrini and Epworth consulting rooms where he sees patients with a full range of haematological disorders. (cancervic.org.au)
- In pilot studies, CDA-2 showed promising results of hematological improvement in these patients. (clinicaltrials.gov)
- Routine biochemical and hematological tests have been reported to be useful in the stratification and prognostication of pediatric and adult patients with diagnosed coronavirus disease (COVID-19), correlating with poor outcomes such as the need for mechanical ventilation or intensive care, progression to multisystem organ failure, and/or death. (degruyter.com)
- This document by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 provides interim guidance on: (A) clinical indications for testing, (B) recommendations for test selection and interpretation, (C) considerations in test interpretation, and (D) current limitations of biochemical/hematological monitoring of COVID-19 patients. (degruyter.com)
- Objectives To evaluate the haematological findings of patients with severe acute respiratory syndrome (SARS). (bmj.com)
- Subjects All patients with a diagnosis of SARS between 11 March and 29 March 2003 who had no pre-existing haematological disorders. (bmj.com)
- Conclusions Abnormal haematological variables were common among patients with SARS. (bmj.com)
- 1 4 This study summarises the haematological findings in patients with SARS who were treated at the Prince of Wales Hospital, Hong Kong. (bmj.com)
- Our study included all consecutive patients who received a diagnosis of SARS and were treated at the Prince of Wales Hospital but excluded patients with a history of haematological disorders. (bmj.com)
- The purpose of this study was to investigate changes in some haematological parameters in patients with type 1 diabetes (T1D) in Sokoto, North Western Nigeria and to compare the results with non-diabetics. (omicsonline.org)
- was determined in 60 patients, attended at the Haematological and Haemotherapeutical Service of "Santa Casa de Misericórdia" of São Paulo, suffering lymphoproliferative diseases (Group 1). (scielo.br)
- As control group (Group 2) 59 persons without haematological diseases, but with the same life time and living at the same place of that of haematological patients, had been examined. (scielo.br)
- Hematological and gastrointestinal toxicities are common among patients treated with cyclophosphamide and doxorubicin for breast cancer. (nature.com)
- To examine whether single-nucleotide polymorphisms (SNPs) in key pharmacokinetic genes were associated with risk of hematological or gastrointestinal toxicity, we analyzed 78 SNPs in ABCB1, ABCC1 and ALDH1A1 in 882 breast cancer patients enrolled in the SWOG trial S0221 and treated with cyclophosphamide and doxorubicin. (nature.com)
- Due to high incidence and mortality from complications in patients with malaria positivity, we have taken up this study to evaluate clinical, haematological and renal alterations in malaria patients proved positive. (thefreelibrary.com)
- To study clinical, hematological and renal alterations in malaria patients proved positive by rapid optimal test and slide positivity in patients admitted to Basaveswara Teaching & General Hospital, Gulbarga. (thefreelibrary.com)
- Pro-inflammatory cytokinemia is frequently found in Down syndrome patients with hematological disorders. (biomedsearch.com)
- Down syndrome (DS) patients are frequently complicated with infections, autoimmune phenomena and hematological disorders, including transient abnormal myelopoiesis (TAM) in infancy and acute megakaryoblastic leukaemia (AMKL) in later life. (biomedsearch.com)
- Patients and Methods: 2239 patients with hematological neoplasms (Table1) were evaluated by whole transcriptome sequencing (WTS) and 64 cases without hematological neoplasms were analysed as controls. (bloodjournal.org)
- The preclinical data indicate that MIV-828 may become a better tolerated and more effective medicine for patients with AML and other hematological cancers. (pharmiweb.com)
- Liver involvement is often observed in several hematological disorders, resulting in abnormal liver function tests, abnormalities in liver imaging studies, or clinical symptoms presenting with hepatic manifestations. (hindawi.com)
- Our purpose was to compile information on the haematological manifestations of systemic lupus erythematosus (SLE), namely leucopenia, lymphopenia, thrombocytopenia, autoimmune haemolytic anaemia (AIHA), thrombotic thrombocytopenic purpura (TTP) and myelofibrosis. (mendeley.com)
- The following discussion will concentrate on the GSDs that have hematological manifestations. (oncologynurseadvisor.com)
- Haematological manifestations of HIV are common and diverse, occurring at all stages of infection. (scielo.org.za)
- Hematological Side Effects of Immune Checkpoint Inhibitors: The Example of Immune-Related Thrombocytopenia Roser Calvo* Patient Safety, Safety Science, AstraZeneca Pharmaceuticals, Gaithersburg, MD, United States Immune-related hematological adverse events are amongst the rare but potentially life-threatening complications of immune checkpoint inhibitors. (medworm.com)
- Cardiovascular and Hematological Disorders-drug Targets was launched in 2001. (benthamscience.com)
- Visualize the composition of the hematological cancers market in terms of dominant molecule types and targets, highlighting what the current unmet needs are and how they can be addressed. (pitchengine.com)
Cancers Therapeutics Market2
- As per the recent study conducted by Reports and Data, the Global Hematological Cancers Therapeutics Market was valued at USD 34.38 Billion in 2019 and is expected to reach USD 72.84 billion by 2027, delivering a CAGR of 9.8% through the forecast period from 2020 to 2027. (medgadget.com)
- In the global industry, North America is expected to dominate the hematological cancers therapeutics market during the forecast period with the surge in the number of leading pharmaceutical companies and the rise in the incidences of blood cancer in the region. (medgadget.com)
- Therefore, we suppose that the lemon detox program reduces body fat and insulin resistance through caloric restriction and might have a potential beneficial effect on risk factors for cardiovascular disease related to circulating hs-CRP reduction without hematological changes. (nih.gov)
- 100 peer reviewed papers and received a number of national and international awards and recognitions including Editor-in-Chief of Cardiovascular and Hematological Disorders-Drug Target, Advisory Professor in Shanghai Jiaotong University School of Medicine, and Councilor of Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology. (benthamscience.com)
- Download PowerPoint presentations from the Lymphomas, leukaemia and other haematological cancers plus late effects of cancer treatment: what GPs need to know workshop for GPs and other health professionals, held at Peter MacCallum Cancer Centre on 4 August 2012. (cancervic.org.au)
- Haematological emergencies occurring in this setting include the high-grade lymphomas, particularly Burkitt lymphoma, and thrombotic thrombocytopenic purpura (TTP). (scielo.org.za)
- Evidence indicates that GCs induce apoptosis in hematological cells, thus supporting their use as chemotherapeutic agents for leukemias, lymphomas, and myeloma. (aacrjournals.org)
- In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms. (mdpi.com)
- Clinical profile of malaria with special reference to hematological and renal alterations. (thefreelibrary.com)
- The present study showed that fluoride caused adverse effects in rats and that resveratrol reduced hematological and biochemical alterations produced by fluoride exposure. (fluoridealert.org)
- To keep up with these changes, key market players are focusing on the launch of novel hematological cancers therapeutics in the market. (medgadget.com)
- The scope of this study covers instruments, reagents, testing, screening technology and the therapeutics markets for hematological disorders, including hemophilia and blood cancers. (finanznachrichten.de)
- He is a past chairman of the Australasian Leukaemia and Lymphoma Group, a co-operative group which conducts clinical research in haematological cancers. (cancervic.org.au)
- The Hematological Cancer Research Investment and Education Act of 2001 (Pub.L. 107-172 (text) (pdf)) amends the Public Health Service Act to allocate funding and establish directed research and education programs targeted at forms of blood cancer, in particular leukemia, lymphoma, and multiple myeloma. (wikipedia.org)
- Blood samples collected from each participant were used to define the immunological and hematological parameters. (dovepress.com)
- The mean, median, and 95% interval values were calculated for the immunological and hematological parameters. (dovepress.com)
- Effects of novelty, isolation stress, and environmental enrichment on some haematological parameters in marmosets (Callithrix penicillata). (priory.com)
- Blood samples were taken and hematological and biochemical parameters were measured. (fluoridealert.org)
- Compared to the control group, the fluoride-treated group showed significant differences in several hematological parameters, including decreases in WBC, RBC, and PLT counts and neutrophil ratio. (fluoridealert.org)
- The hematological and biochemical parameters in the fluoride? (fluoridealert.org)
- An attempt has been made in the present investigation to determine the acute toxicity of hexavalent chromium and its toxicological effects on survival, physiological, hematological and biochemical parameters of the widely consumed Indian major carp, Labeo rohita . (mdpi.com)
Complications of HIV infection1
- Medical professionals across all disciplines need to be alert to the haematological complications of HIV infection. (scielo.org.za)
- Hematological Disorders in Children will appeal to a wide readership, from medical students and beginning investigators to experienced scholars in the field of pediatric hematology and oncology seeking to broaden their understanding and keep up with the latest developments. (springer.com)
- A two-SNP haplotype in ALDH1A1 was associated with an increased risk of grade 3 and 4 hematological toxicity (odds ratio=1.44, 95% confidence interval=1.16-1.78), which remained significant after correction for multiple comparisons. (nature.com)
- This publication outlines strategies and offers guidance on the detection, diagnosis, risk assessment, monitoring and management of immune-related thrombocytopenia, a relatively common example of immune-related hematological toxicity of immune checkpoint inhibitors. (medworm.com)
- The blood cells (erythrocytes, granulocytes, and platelets) and the tissues that form them ((bone marrow, spleen, and lymph nodes) make up the hematological system . (cdc.gov)
- Background: Resistance to apoptosis is one of the hallmarks in hematological neoplasms, most typically via dysregulation of the intrinsic mitochondrial pathway. (bloodjournal.org)
- Aim: To determine the gene expression levels of BCL2 , BCL2L1 and MCL1 across various hematological neoplasms in order to identify best candidates for pro-survival protein inhibitors. (bloodjournal.org)
- 2 3 Viral infection may produce various haematological changes. (bmj.com)
- Hematological studies showed that the infection gave rise to severe anemia, and histopathological investigations in various organs showed multifocal inflammatory infiltrates associated with extramedullary hematopoiesis in the liver, and cerebral edema. (plos.org)
- ALAN WOOLF and DAVID C. KRADEL "MORTALITY IN CAPTIVE BIGHORN SHEEP - CLINICAL, HEMATOLOGICAL, AND PATHOLOGICAL OBSERVATIONS," Journal of Wildlife Diseases 9(1), 12-17, (1 January 1973). (bioone.org)
- The present review sets out their application in hematological diseases. (medigraphic.com)
- monoclonal antibodies, hematological diseases. (medigraphic.com)
- On November 27, 2001, we published "Revised Medical Criteria for Evaluating Hematological Disorders and Malignant Neoplastic Diseases" as an NPRM in the Federal Register ( 66 FR 59306 ). (federalregister.gov)
- This NPRM proposed to revise the criteria in the Listing of Impairments (the listings) that we use to evaluate claims involving hematological disorders and malignant neoplastic diseases. (federalregister.gov)
- Using the numerical framework, this allocation will help researchers gain quantitative understanding of several other hematological disorders such as hereditary spherocytosis (HS) and hereditary elliptocytosis (HE), which are inherited blood diseases that result in anemia. (anl.gov)
- A breakdown of the market by hematological diseases, hematological cancers, and hematological diagnostics. (finanznachrichten.de)
- The aim of our study was to determine the haematological characteristics of MYH9 disorders as a result of R702 mutations to aid in making a proper diagnosis. (ingentaconnect.com)
- Over the last years, targeted anti-cancer therapy with small-molecule inhibitors and antibodies moved to the forefront as a strategy to treat hematological cancers. (springer.com)
- There are today 700 companies plus partners developing 1147 hematological cancer drugs in 2542 developmental projects in cancer. (marketresearch.com)
- This Drug Pipeline Update contains 1147 hematological cancer drugs in development, which have a total of 2542 developmental projects in cancer. (marketresearch.com)
- Included hematological cancer drugs are also in development for 406 other indications, where of 226 are different cancer indications. (marketresearch.com)
- The report assesses first-in-class innovation in the hematological cancer pipeline, highlighting key trends in first-in-class product distribution. (pitchengine.com)
- Analysis reveals that the hematological cancer pipeline is among the most innovative in the industry, with 463 first-in-class products, representing 45.3% of the pipeline with a disclosed molecular target. (pitchengine.com)
- Immatics biotechnologies, which is working on hematological cancer therapy, recently received $50 million in funding from an adoptive cell therapy deal in solid tumor indications with GlaxoSmithKline plc. (medgadget.com)
- Streamline your comprehensive hematological cancer sample profiling. (thermofisher.com)
- We also offer established technologies such as real-time PCR, Sanger sequencing, and fragment analysis for the detection of low-level fusion genes, somatic mutations, and CNVs in hematological cancer samples. (thermofisher.com)
- The report also discusses the regulatory environment, current technologies, new technologies, hematological disorders and cancer incidence, market projections and market share, along with latest trends, and clinical and new developments. (finanznachrichten.de)
- Unconditional logistic regression analyses included 3119 haematological cancer deaths (cases) and 90 935 deaths from other causes (controls). (bmj.com)
- Results Growing up on a livestock farm was positively associated with haematological cancer (OR 1.22, 95% CI 1.05 to 1.41), particularly for poultry farms (OR 2.99, 95% CI 1.44 to 6.21), while growing up on a crop farm was not (OR 0.81, 95% CI 0.64 to 1.03). (bmj.com)
- Crop farming in adulthood was associated with an increased haematological cancer risk (OR 1.49, 95% CI 1.13 to 1.96), while livestock farming was not (OR 0.80, 95% CI 0.63 to 1.00), except for beef cattle farming (OR 2.99, 95% CI 1.28 to 7.00). (bmj.com)
- Hematological analyses included total and differential white blood cell count, red blood cell count and morphology, and plasma glucose concentration. (scielo.br)
- The aim of this study was to determine the immunological and hematological reference intervals in healthy pregnancy among HIV-seronegative pregnant women in northwest Ethiopia. (dovepress.com)
- This study investigated the haematological state of captive marmosets submitted to a chronic psychogenic stress, an environmental enrichment, or a control condition. (priory.com)
- In the present study, fish Labeo rohita were exposed to 20, 50 and 100 µg/L of both Cu NPs and copper sulphate (CuSO4, bulk copper) for 24 h and hematological profiles were estimated. (igi-global.com)
- Pregnancy is a state characterized by profound physiological hematological changes. (dovepress.com)
- This book describes the pathogenesis and treatment of several representative hematological disorders in children, with a special focus on genetic and molecular aspects. (springer.com)
- Conclusions These results could suggest a role for early life biological exposures in the development of haematological cancers. (bmj.com)
- The use of haematological indicators in vivo, nonetheless, enables a more comprehensive approach to evaluate the impact of psychogenic stress. (priory.com)
- This review will attempt to clarify the complex signaling pathway responsible for mediating GC-induced apoptosis of hematological cells and to summarize the most current research in this field. (aacrjournals.org)
- Studies on several genetic hematological traits of the Mexican population. (wiley.com)
- Rubén Lisker , María S. Córdova , Q. B. P. Graciela Zárate , Studies on several genetic hematological traits of the Mexican population. (wiley.com)
- Accuracy of DNA amplification from archival hematological slides for use in genetic biomarker studies. (aacrjournals.org)
- Our findings suggest that high fidelity DNA amplification can be achieved using archival hematological slides as old as 29 years and can be reliably used in genetic analyses. (aacrjournals.org)
- Analyze the hematological cancers pipeline and stratify by stage of development, molecule type and molecular target. (pitchengine.com)
- To assess the clinical effectiveness and safety of haematological interventions such as heparins (low molecular weight heparin (LMWH) and unfractionated heparin (UFH), danaparoid sodium, synthetic protease inhibitor, antithrombin, human recombinant activated protein C, recombinant human soluble thrombomodulin, recombinant tissue factor pathway inhibitor, recombinant activated factor VIIa and any other types of haematological interventions (except transfusions) for treating DIC during pregnancy and postpartum. (cochrane.org)