Osteotomy, Sagittal Split Ramus
Pakistan
Environment
Models, Biological
Molecular Sequence Data
Signal Transduction
Host haematological factors influencing the transmission of Plasmodium falciparum gametocytes to Anopheles gambiae s.s. mosquitoes. (1/592)
We investigated the relationship between selected host haematological and parasitological parameters and the density and infectivity of Plasmodium falciparum gametocytes. 143 individuals (age range 1-62 years) attending an outpatient clinic in Farafenni, The Gambia, who had peripheral blood gametocytaemia were recruited (mean gametocyte density 123.7/microl, range 5-17,000/microl). Of the parameters measured, packed cell volume (PCV), reticulocyte count (RetC) and lymphocyte count (LyC) were significantly associated with gametocyte density (r = - 0.17, P < 0.05; r = 0.21, P < 0.01; r = 0.18, P < 0.05, respectively). Data from membrane feeding experiments in which 15 or more mosquitoes were dissected showed that 60.7% (53/87) of gametocyte carriers infected one or more mosquitoes. Gametocyte density was strongly correlated with transmission success (TS) (r = 0.3, P < 0.005) and, in successful infections, with both mosquito prevalence (MP) (r = 0.36, P < 0.005) and mean oocyst burden (MOB) (r = 0.65, P < 0.0001). None of the other factors measured were significantly associated with any of these indices in bivariate analysis. Regression modelling showed that both gametocyte density and PCV were positively associated with gametocyte carrier infectivity to mosquitoes (LRchi2 = 100.7 and 47.2, respectively) and, in successful infections, with MOB (beta = 0.16, t = 4.9, P < 0.001; beta = 0.02, t = 2.3, P < 0.05, respectively). The positive association with PCV suggests that blood meal quality influences infection probably as a nutritional requirement, however, as this effect was most apparent at high gametocyte densities, its epidemiological significance is questionable. Though the haematological parameters associated with gametocyte density are a direct consequence of asexual infection, they may also represent an adaptive mechanism for optimization of sexual stage development. (+info)Urinary tract toxicity in rats following administration of beta 3-adrenoceptor agonists. (2/592)
ZD7114, [(S)-4-[2-(2-hydroxy-3 phenoxypropylamine)ethoxy]-N-(2-methoxyethyl) phenoxyacetamide], and ZD2079, [(R)-N-(2-[4- (carboxymethyl)phenoxy]ethyl)-N-(beta-hydroxyphenethyl)ammonium chloride], are beta 3-adrenoceptor stimulants with selectivity for brown adipose tissue. ZD7144 is the hydrochloride salt of the S-enantiomer of the racemic amide ZD2079. They were developed as potential novel treatments for obesity and non-insulin-dependent diabetes mellitus. Male and female rats were dosed separately by gavage for a minimum of 28 days with 0, 10, 50, and 500 mg/kg/day of ZD7114 or with 0, 10, 30, and 150 mg/kg/day of ZD2079. Two further groups of male and female rats were dosed with 0 and 500 mg/kg/day of ZD7114 for 28 days and were then allowed a 6-wk, undosed withdrawal period. At high doses, both compounds caused urinary tract toxicity, which primarily affected the distal tubules and collecting ducts of the kidney via tubular necrosis. They also caused ureteric inflammation, cystitis, and accumulation of crystalline inclusions throughout the urinary tract. As a result of urinary tract toxicity, affected animals from one or both studies showed reduced red blood cell indices, lower platelet counts, and higher white cell counts. Blood chemistry revealed lower plasma concentrations of glucose (7.28 +/- 1.37 compared to 8.11 +/- 0.65 for the control) and total protein (63.42 +/- 3.65 compared to 69.17 +/- 3.24 for the control) and increased plasma urea (37.15 +/- 19.96 compared to 8.09 +/- 0.87 for the control). Urinalysis showed an increase in the number of crystals, blood, and protein. In the urinary tract, the severe crystalluria with accumulation of crystalline material indicated that this may have a role in the etiology of the target organ toxicity. Poor solubility of the compounds at normal urinary pH was considered a possible mechanism for the crystalluria. (+info)Effects of carbon dioxide inhalation on hematology, coagulation, and serum clinical chemistry values in rats. (3/592)
Blood samples from adult male and female Charles River Crl:CD (SD) BR rats were collected at weekly intervals for 4 wk to evaluate the effects of inhalation of an anesthetic dose of carbon dioxide (CO2) or of a carbon dioxide-oxygen mixture (CO2/O2) on hematology, coagulation, and serum biochemistry values. During the first 3 wk of the study, rats were assigned to 1 of 3 groups and were bled from the orbital sinus once weekly. Prior to the blood collection, rats in group 1 were exposed to room air only, rats in group 2 received CO2/O2 (approximately 66%:34% CO2:O2) by inhalation, and rats in group 3 received 100% CO2 by inhalation. In the rats exposed to CO2/O2 or CO2, leukocyte counts, lymphocyte counts, and glucose values were higher, and aspartate aminotransferase, creatine kinase, and calcium values were lower compared with those of rats exposed to room air only. Rats exposed to 100% CO2 had slightly (but statistically significant) lower mean corpuscular hemoglobin concentration when compared with rats exposed only to room air. During week 4, all rats were reassigned to 1 of 2 groups and were bled terminally via closed cardiac puncture following exposure to either CO2/O2 or CO2. Increased lymphocyte counts (males only) and glucose and chloride concentrations were noted for rats exposed to CO2/O2 compared with those exposed to CO2. These alterations reiterate the importance of comparing clinical pathology values to those of concurrent control groups that have experienced blood collection under identical conditions in order to avoid potential errors in the interpretation of data. (+info)Immunohematological reference ranges for adult Ethiopians. (4/592)
A cross-sectional survey was carried out with 485 healthy working adult Ethiopians who are participating in a cohort study on the progression of human immunodeficiency virus type 1 (HIV-1) infection to establish hematological reference ranges for adult HIV-negative Ethiopians. In addition, enumeration of absolute numbers and percentages of leukocyte subsets was performed for 142 randomly selected HIV-negative individuals. Immunological results were compared to those of 1,356 healthy HIV-negative Dutch blood donor controls. Immunohematological mean values, medians, and 95th percentile reference ranges were established. Mean values were as follows: leukocyte (WBC) counts, 6.1 x 10(9)/liter (both genders); erythrocyte counts, 5.1 x 10(12)/liter (males) and 4.5 x 10(12)/liter (females); hemoglobin, 16.1 (male) and 14.3 (female) g/dl; hematocrit, 48.3% (male) and 42.0% (female); platelets, 205 x 10(9)/liter (both genders); monocytes, 343/microl; granulocytes, 3, 057/microl; lymphocytes, 1,857/microl; CD4 T cells, 775/microl; CD8 T cells, 747/microl; CD4/CD8 T-cell ratio, 1.2; T cells, 1, 555/microl; B cells, 191/microl; and NK cells, 250/microl. The major conclusions follow. (i) The WBC and platelet values of healthy HIV-negative Ethiopians are lower than the adopted reference values of Ethiopia. (ii) The absolute CD4 T-cell counts of healthy HIV-negative Ethiopians are considerably lower than those of the Dutch controls, while the opposite is true for the absolute CD8 T-cell counts. This results in a significantly reduced CD4/CD8 T-cell ratio for healthy Ethiopians, compared to the ratio for Dutch controls. (+info)Effect of dietary alpha-linolenic acid on thrombotic risk factors in vegetarian men. (5/592)
BACKGROUND: Vegetarians have lower platelet and plasma concentrations of n-3 polyunsaturated fatty acids (PUFAs) than do omnivores. We recently showed that male vegetarians have higher platelet aggregability than do omnivores. OBJECTIVE: We investigated whether male vegetarians (n = 17) who consumed an increased amount of dietary alpha-linolenic acid (ALA) showed any changes in their tissue profile of PUFAs, plasma thromboxane concentrations, platelet aggregability, or hemostatic factors. DESIGN: During the study, all subjects maintained their habitual vegetarian diets except that a proportion of dietary fat was replaced with vegetable oils and margarines that were provided. Initially, all subjects consumed a low-ALA diet (containing safflower oil and safflower oil-based margarine) for 14 d; they then consumed either a moderate-ALA diet (containing canola oil and canola oil-based margarine) or a high-ALA diet (containing linseed oil and linseed oil-based margarine) for 28 d. Blood samples were collected at day 0 (baseline), day 14, and day 42. RESULTS: Eicosapentaenoic acid, docosapentaenoic acid, total n-3 PUFAs, and the ratio of n-3 to n-6 PUFAs were significantly increased (P < 0.05), whereas the ratio of arachidonic acid to eicosapentaenoic acid was decreased (P < 0.05), in platelet phospholipids, plasma phospholipids, and triacylglycerols after either the moderate-ALA or high-ALA diet compared with the low-ALA diet. No significant differences were observed in thrombotic risk factors. CONCLUSION: ALA from vegetable oils (canola and linseed) has a beneficial effect on n-3 PUFA concentrations of platelet phospholipids and plasma lipids in vegetarian males. (+info)Effects of long-term intake of retinol on selected clinical and laboratory indexes. (6/592)
BACKGROUND: Chemopreventive agents developed to be used in a moderate-risk but otherwise healthy population need to be both efficacious and to have minimal adverse effects. OBJECTIVE: The objective of this study was to evaluate the adverse effects of long-term retinol intake in a skin cancer chemoprevention trial in a large population at moderate risk for skin cancer. DESIGN: Participants (n = 2297) were randomly assigned to receive retinol [7576 retinol equivalents (RE), or 25000 IU] or a placebo daily. The adverse effects of retinol intake were studied by monitoring 14 clinical symptoms and laboratory indexes. The median follow-up time was 3.8 y. RESULTS: No adverse effects concerning the 14 symptoms were observed. Significant differences in alkaline phosphatase (P < 0.0001), triacylglycerol (P < 0.0001), cholesterol (P = 0.04), and HDL (P = 0.01) were observed over time between the 2 groups. After 49 mo of follow-up, alkaline phosphatase was 7% higher, triacylglycerol was 11% higher, cholesterol was 3% higher, and HDL was 1% lower in the retinol group than in the placebo group. CONCLUSIONS: Because a 1% increase in cholesterol concentrations has been reported to be associated with a 2% increase in coronary artery disease risk, long-term ingestion of 7576 RE vitamin A/d should be considered with caution. However, further studies are needed to confirm this finding. (+info)Chronic inhalation carcinogenicity study of commercial hexane solvent in F-344 rats and B6C3F1 mice. (7/592)
The carcinogenic and chronic toxicity potential of commercial hexane solvent was evaluated in F-344 rats and B6C3F1 mice (50/sex/concentration/species) exposed by inhalation for 6 h/day, 5 days/week for 2 years. Target hexane vapor concentrations were 0, 900, 3000, and 9000 ppm. There were no significant differences in survivorship between control and hexane-exposed groups, and clinical observations were generally unremarkable. Small, but statistically significant decreases in body weight gain were seen in rats of both sexes in the mid- and high-exposure groups and in high-expsoure female mice. The only noteworthy histopathological finding in rats was epithelial cell hyperplasia in the nasoturbinates and larynx of exposed groups. This response was judged to be indicative of upper respiratory tract tissue irritation. No significant differences in tumor incidence between control and hexane-exposed rats were found. In mice, uterine tissue from the high-exposure females exhibited a significant decrease in the severity of cystic endometrial hyperplasia compared to controls. An increase in the combined incidence of hepatocellular adenomas and carcinomas was observed in high-exposure female mice. The incidence of liver tumors was not increased in the mid- or low-exposure female mice or in male mice exposed to hexane. An increased incidence of pituitary adenomas was observed in female, but not male mice. This finding was not believed to have been treatment-related because the incidence in the control group was unusually low, and the incidence in exposed groups was not dose-related and was within the historical control range. No other neoplastic changes judged to be treatment-related were observed in tissues from male or female mice. In conclusion, chronic exposure to commercial hexane solvent at concentrations up to 9000 ppm was not carcinogenic to F-344 rats or to male B6C3F1 mice, but did result in an increased incidence of liver tumors in female mice. (+info)Retrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals. (8/592)
AIMS: To estimate the frequency of adverse drug reactions (ADRs) identified through the use of automatic signals generated from laboratory data (ALS) in hospitalised patients. To determine the frequency of spontaneous recognition of these ADRs by the attending physicians and to assess the potential value of ALS for detection of ADRs. METHODS: Laboratory results of patients hospitalised in a nine bed medical ward were automatically recorded over a period of 17 months. Values exceeding defined boundaries were used as ALS. Charts of every third patient were analysed retrospectively with regard to adverse drug related reactions and causality was evaluated as well as whether the ADR had been recognised during the period of hospitalisation. RESULTS: The charts and ALS of 98 patients were analysed. In 18 cases a drug-related adverse reaction was probable. Awareness to the reaction by the treating physicians was evident in 6 out of these 18 ADRs. Approximately 80% of the ADRs were considered predictable. Three ADRs were regarded as serious. CONCLUSIONS: Adverse drug reactions are common and often preventable. Only one third of ADRs which could have been detected through ALS were recognised by the attending physicians. An increased doctor's awareness of the frequency of drug related abnormal laboratory results by means of ALS is likely to increase the recognition rate of ADRs and might help to prevent them. (+info)Hematologic tests, also known as hematology tests, are a group of diagnostic exams that evaluate the health and function of different components of blood, such as red and white blood cells, platelets, and clotting factors. These tests can detect various disorders, including anemia, infection, bleeding problems, and several types of cancer. Common hematologic tests include complete blood count (CBC), coagulation studies, peripheral smear examination, and erythrocyte sedimentation rate (ESR). The specific test or combination of tests ordered will depend on the patient's symptoms, medical history, and physical examination findings.
Sagittal split ramus osteotomy (SSRO) is a specific type of orthognathic surgery, which is performed on the ramus of the mandible (lower jaw). The procedure involves making a surgical cut in the ramus bone in a sagittal direction (splitting it from front to back), and then splitting the bone further into two segments. These segments are then repositioned to correct dentofacial deformities, such as jaw misalignment or asymmetry. The procedure is often used to treat severe cases of malocclusion (bad bite) and jaw joint disorders. After the bones are repositioned, they are stabilized with plates and screws until they heal together in their new position.
I'm sorry for any confusion, but "Pakistan" is a country in South Asia and not a medical term or condition. If you have any medical questions or terms you would like defined, I would be happy to help!
The term "environment" in a medical context generally refers to the external conditions and surroundings that can have an impact on living organisms, including humans. This includes both physical factors such as air quality, water supply, soil composition, temperature, and radiation, as well as biological factors such as the presence of microorganisms, plants, and animals.
In public health and epidemiology, the term "environmental exposure" is often used to describe the contact between an individual and a potentially harmful environmental agent, such as air pollution or contaminated water. These exposures can have significant impacts on human health, contributing to a range of diseases and disorders, including respiratory illnesses, cancer, neurological disorders, and reproductive problems.
Efforts to protect and improve the environment are therefore critical for promoting human health and preventing disease. This includes measures to reduce pollution, conserve natural resources, promote sustainable development, and mitigate the impacts of climate change.
Biological models, also known as physiological models or organismal models, are simplified representations of biological systems, processes, or mechanisms that are used to understand and explain the underlying principles and relationships. These models can be theoretical (conceptual or mathematical) or physical (such as anatomical models, cell cultures, or animal models). They are widely used in biomedical research to study various phenomena, including disease pathophysiology, drug action, and therapeutic interventions.
Examples of biological models include:
1. Mathematical models: These use mathematical equations and formulas to describe complex biological systems or processes, such as population dynamics, metabolic pathways, or gene regulation networks. They can help predict the behavior of these systems under different conditions and test hypotheses about their underlying mechanisms.
2. Cell cultures: These are collections of cells grown in a controlled environment, typically in a laboratory dish or flask. They can be used to study cellular processes, such as signal transduction, gene expression, or metabolism, and to test the effects of drugs or other treatments on these processes.
3. Animal models: These are living organisms, usually vertebrates like mice, rats, or non-human primates, that are used to study various aspects of human biology and disease. They can provide valuable insights into the pathophysiology of diseases, the mechanisms of drug action, and the safety and efficacy of new therapies.
4. Anatomical models: These are physical representations of biological structures or systems, such as plastic models of organs or tissues, that can be used for educational purposes or to plan surgical procedures. They can also serve as a basis for developing more sophisticated models, such as computer simulations or 3D-printed replicas.
Overall, biological models play a crucial role in advancing our understanding of biology and medicine, helping to identify new targets for therapeutic intervention, develop novel drugs and treatments, and improve human health.
Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.
Signal transduction is the process by which a cell converts an extracellular signal, such as a hormone or neurotransmitter, into an intracellular response. This involves a series of molecular events that transmit the signal from the cell surface to the interior of the cell, ultimately resulting in changes in gene expression, protein activity, or metabolism.
The process typically begins with the binding of the extracellular signal to a receptor located on the cell membrane. This binding event activates the receptor, which then triggers a cascade of intracellular signaling molecules, such as second messengers, protein kinases, and ion channels. These molecules amplify and propagate the signal, ultimately leading to the activation or inhibition of specific cellular responses.
Signal transduction pathways are highly regulated and can be modulated by various factors, including other signaling molecules, post-translational modifications, and feedback mechanisms. Dysregulation of these pathways has been implicated in a variety of diseases, including cancer, diabetes, and neurological disorders.
An amino acid sequence is the specific order of amino acids in a protein or peptide molecule, formed by the linking of the amino group (-NH2) of one amino acid to the carboxyl group (-COOH) of another amino acid through a peptide bond. The sequence is determined by the genetic code and is unique to each type of protein or peptide. It plays a crucial role in determining the three-dimensional structure and function of proteins.
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Malignancies8
- The value of an immunoenzymatic test (enzyme-linked immunosorbent assay) for the diagnosis of strongyloidiasis in patients immunosuppressed by hematologic malignancies. (ajtmh.org)
- In the present study, we evaluated the enzyme-linked immunosorbent assay (ELISA) in patients with hematologic malignancies. (ajtmh.org)
- The ELISA may be an excellent assay to rule out the diagnosis of strongyloidiasis in patients with hematologic malignancies. (ajtmh.org)
- This series of interactive webinars will provide clinicians across the care spectrum treating hematologic malignancies with a foundational understanding of genomics, current applications and advances, and practical strategies to apply these findings to treating patients. (schoolandyouth.org)
- Studies are being planned for testing in hematologic malignancies, additional solid tumors and other immunology-focused indications. (wspa.com)
- Dr Deininger is professor of hematology and hematologic malignancies in the Department of Internal Medicine at the Medical College of Wisconsin and director of the Versiti Blood Research Institute. (medscape.com)
- This educational activity is based on case presentations and subsequent small group discussions of patients with hematologic malignancies that are being evaluated, treated and followed in the Department of Hematology and Oncology, and that have diagnostic or follow-up material evaluated in the Division of Hematopathology. (mcw.edu)
- Determine the clinical effectiveness of bevacizumab, cytarabine, and mitoxantrone in patients with poor-risk hematologic malignancies. (knowcancer.com)
Cancers1
- The tests can also help to diagnose diseases and conditions such as anemia , infections, clotting problems, blood cancers, and immune system disorders . (medlineplus.gov)
Neoplasms1
- Acute myeloid leukemias (AMLs) are heterogeneous hematologic neoplasms characterized by myeloblast or promyelocyte proliferation without normal differentiation. (koreamed.org)
Diagnosis6
- Additionally, the field of cytogenetics is important in the diagnosis and workup of patients with hematologic/oncologic disorders. (wakehealth.edu)
- Cytogenetic testing in this area is used for diagnosis, classification of disease, determining treatment regimens, and to monitor disease status and recovery. (wakehealth.edu)
- Diagnosis is made from history and exam in patients with known risk factors such as diabetes, but objective test confirmation is recommended for patients without known risks. (nih.gov)
- Molecular diagnostic testing using nucleic-acid-based assays provides a means for quick and accurate diagnosis and identification of infectious diseases. (clpmag.com)
- The A1C test should also be repeated to confirm a diagnosis. (nih.gov)
- Primary ALL cells are accessible for drug sensitivity testing at the time of new diagnosis or at relapse, but there are major limitations with current methods for determining drug sensitivity ex vivo. (bvsalud.org)
Disorders2
- Emphasis is placed on the study of hematologic disorders, abnormal cell development and morphology, and related testing. (southwesterncc.edu)
- This test helps diagnose and monitor bleeding disorders. (medicalnewstoday.com)
Hematological tests1
- Hundreds of hematological tests and procedures have been developed, and many can be carried out simultaneously on one sample of blood with such instruments as autoanalyzers. (britannica.com)
Hematology1
- The book features new sections on Hematotoxicity and Quality Control and Laboratory Techniques, and includes expanded sections on Laboratory Animal Hematology, Species Specific Hematology, and Hematologic Neoplasia. (chipsbooks.com)
Acute1
- Review of the available literature obtained from both acute and chronic experiments utilizing rats, mice and chickens treated with Cl02, Cl02 and Cl03 in drinking water has demonstrated alterations in hematologic parameters in all species tested. (epa.gov)
Indications1
- Please provide indications (ICD-9) for testing on our referral form with each specimen. (wakehealth.edu)
Liver2
Diseases2
- This test can help diagnose anemia , inflammatory diseases, and blood cancer. (medicalnewstoday.com)
- The fact sheet, called The A1C Test and Diabetes, offers in-depth information for people being tested," said Judith Fradkin, M.D., a diabetes specialist at the NIH's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (nih.gov)
Abnormal3
- We determined the prevalence of each abnormal blood-test result (ABTR) in the iiSFPN cohort, compared this to population averages, and measured the costs of screening subjects to obtain one ABTR. (nih.gov)
- The six most cost-effective iiSFPN-associated blood tests-ESR, ANA, C3, autoantibodies for Sjögren's and celiac, plus thyroid-stimulating hormone-had estimated cost of $99.57/person and 45.6 % probability of obtaining one abnormal result. (nih.gov)
- The serum iron test measures the amount of iron in the blood, and if the levels are abnormal it can cause serious health problems. (anylabtestnow.com)
Hemoglobin3
- Many tests are designed to determine the number of erythrocytes and leukocytes in the blood, together with the volume, sedimentation rate, and hemoglobin concentration of the red blood cells ( blood count ). (britannica.com)
- The test is sometimes referred to as the hemoglobin A1c, HbA1c, or glycohemoglobin test. (nih.gov)
- For example, people of African, Mediterranean or Southeast Asian descent, or people who have a family member with sickle cell anemia, may not know that they have a less common type of hemoglobin that can interfere with some A1C tests. (nih.gov)
Precision Medicine2
- PrismRA, a molecular signature test, is a revolutionary advancement bringing precision medicine to the treatment of rheumatoid arthritis, which affects 20 million patients globally. (b3cnewswire.com)
- Here, we describe a functional precision medicine method using a fluorescence imaging platform to test drug sensitivity profiles of primary ALL cells. (bvsalud.org)
Specimen1
- Test results generally take between 24 to 72 business hours after your specimen is collected. (anylabtestnow.com)
Baseline1
- An episode of testing typically requires a baseline assay and multiple follow-up assays. (codemap.com)
Neurologic1
- if neurologic symptoms or other clinical features prompt testing, a CBC should be performed. (arupconsult.com)
Sensitivity4
- While conventional bacterial and viral laboratory tools have been used traditionally, they are limited by time, cost, additional testing requirements, and sensitivity and specificity testing, as well as wait times for pathogen identification. (clpmag.com)
- However, RIDTs have limited sensitivity to detect influenza virus infection and negative test results should be interpreted with caution given the potential for false negative results. (cdc.gov)
- However, negative RIDT results do not exclude influenza virus infection as a cause of a respiratory outbreak because of the limited sensitivity of these tests. (cdc.gov)
- This fluorescence imaging-based protocol enhances previous ex vivo drug sensitivity assays and improves efficiency by requiring fewer primary cells while increasing the number of drugs tested to 40. (bvsalud.org)
Patients17
- Between April 1995 and December 1998, sera from 164 consecutive patients were tested for the presence of IgG antibody to Strongyloides stercoralis. (ajtmh.org)
- The campaign aims to help clinicians and patients engage in conversations about unnecessary tests, treatments and procedures, and to assist physicians and patients in making informed and effective choices to ensure high quality care. (wikipedia.org)
- These unnecessary tests and procedures take away from care by potentially exposing patients to harm, leading to more testing to investigate false positive tests, and contributing to unnecessary anxiety and avoidable costs for patients. (wikipedia.org)
- These lists are intended to encourage clinicians to adopt a "think twice" attitude to avoid unnecessary and potentially harmful tests and procedures, and to foster discussions between patients and clinicians about inappropriate care. (wikipedia.org)
- In the first wave of the campaign, nine national medical specialty societies released evidence-based lists of 41 tests, treatments and procedures that provided no benefit or potentially caused harm to patients. (wikipedia.org)
- WALTHAM, MA, June 24, 2021 / B3C newswire / -- Scipher Medicine , a precision immunology company matching patients with the most effective therapy, today announced positive results from a multicenter, blinded prospective observational clinical study assessing the ability of the PrismRA test to predict which patients with rheumatoid arthritis are unlikely to respond to tumor necrosis factor-alpha inhibitor (TNFi) therapies either when prescribing initial targeted therapy or when modifying treatment. (b3cnewswire.com)
- Scipher Medicine will use proceeds to expand commercial efforts for its patient molecular signature test, PrismRA® , ensuring rheumatoid arthritis patients are prescribed optimal targeted therapy from day one, and data collaborations to discover novel treatment targets based on their large and growing patient clinico-genomic database generated from tested patients. (b3cnewswire.com)
- Records were reviewed from all 213 patients with SFPN confirmed by distal-leg skin biopsy, nerve biopsy, or autonomic-function testing in our academic center during 2013. (nih.gov)
- Angiotensin-converting enzyme was elevated in 45 %, but no patients had sarcoidosis, so this test was futile here. (nih.gov)
- The Molecular Genetics Laboratory at Cincinnati Children's performs a variety of tests for patients of all ages. (cincinnatichildrens.org)
- For patients with or without cancer (as defined in the policy), established standard-of-care MRD tests using single-gene PCR (i.e. (codemap.com)
- For patients with cancer, the unit of service for this type of test is 1. (codemap.com)
- For patients without cancer (as defined in the policy), a second kind of test may exist wherein a single timepoint may constitute a single test (i.e., 1 UOS for a given date of service). (codemap.com)
- Testing in these patients will be accompanied by the appropriate 'Personal history of cancer' ICD-10 code. (codemap.com)
- Therefore, antiviral treatment should not be withheld from patients with suspected influenza, even if they test negative. (cdc.gov)
- L'objectif de notre étude est de décrire les caractéristiques hématologiques des patients atteints de COVID-19 hospitalisés au niveau du CHU d'Oran en Algérie. (bvsalud.org)
- Patients et méthodes : Il s'agit d'une étude prospective menée entre le 1er Juillet et le 15 Octobre 2020 ayant inclus des patients hospitalisés et/ou suivis au niveau des unités COVID-19 du CHU Oran en Algérie. (bvsalud.org)
Assays2
- A Minimal Residual Disease (MRD) test, as defined in the related policy, is a service that may include multiple components and/or multiple timepoints (i.e., serial assays). (codemap.com)
- Rapid molecular assays are a new type of influenza diagnostic test that use isothermal nucleic acid amplification for viral detection. (cdc.gov)
Clinical5
- The campaign is based on the notion that unnecessary tests, treatments, and procedures often do more harm than good, resulting in poor clinical outcomes and significant waste in the Canadian healthcare system. (wikipedia.org)
- The study, published in Rheumatology and Therapy , demonstrated that the test consistently predicted non-response to TNFi therapy across two independent cohorts, the CERTAIN cohort, a retrospective analysis, and a multi-center blinded prospective observational clinical study, NETWORK-004, among 391 targeted therapy-naïve and 113 TNFi-exposed patient samples. (b3cnewswire.com)
- The routine working of the clinical laboratory scientist is the microscopic analysis, chemical, immunologic, bacteriologic, biologic and hematologic tests and preparation of the reports and interpretations. (bitrebels.com)
- Now people can be tested for diabetes without fasting," said David Sacks, Ph.D., chair of a group working to standardize lab testing for diabetes and a member of the NIH Clinical Center's Department of Laboratory Medicine. (nih.gov)
- Clinical signs and symptoms consistent with influenza o Having clinical signs and symptoms consistent with influenza increases the pre-test probability of influenza virus infection, which increases the reliability of a positive RIDT result. (cdc.gov)
Results13
- Additional testing for vitamin B 12 and/or folate deficiency and antibody testing for pernicious anemia may be performed based on the results of these initial tests. (arupconsult.com)
- Which laboratory test results should prompt testing for megaloblastic anemia? (arupconsult.com)
- When will I get my test results? (anylabtestnow.com)
- If I have questions about my tests results who should I contact? (anylabtestnow.com)
- bioMérieux's EasyQ MRSA test, a new molecular diagnostic assay for rapid, automated MRSA screening, targets two different nucleic acid sequences, adding confidence to positive screening results. (clpmag.com)
- She was transferred to Intensive Care Unit and underwent laboratory tests, but all results were normal. (surgicalneurologyint.com)
- Lab tests and results, particularly the A1C, can be confusing. (nih.gov)
- We hope this fact sheet will help people better understand why the test is important, how to interpret results, and why results may differ from expected. (nih.gov)
- To confirm positive results, people should return on a different day to repeat the tests. (nih.gov)
- If you have a family history of sickle cell or thalassemia, or A1C results seem very different from those of a blood glucose test, talk to your doctor about which A1C tests are appropriate for you. (nih.gov)
- Adjust the dosage according to the patient's coagulation test results. (medscape.com)
- Time from illness onset to collection of respiratory specimens for testing o Testing specimens collected within 48-72 hours of illness onset (when influenza viral shedding is highest) is more likely to yield positive RIDT results. (cdc.gov)
- Tests were performed for (1) HIV, (2) complete blood cell count, (3) hepatitis B virus, (4) malaria, (5) syphilis, (6) C-reactive protein and (7) hepatitis C virus.Results: We enrolled 294 healthy participants (161 men, 133 women) aged 18 to 55 years. (bvsalud.org)
Laboratory2
- This study aimed to evaluate the usefulness of laboratory tests for light-chain clonality and bone marrow (BM) findings in. (koreamed.org)
- Public health authorities should be notified of any suspected institutional outbreak and respiratory specimens should be collected from ill persons (whether positive or negative by RIDT) and sent to a public health laboratory for more accurate influenza testing. (cdc.gov)
Diagnostic3
- All tests must be registered with the DEXâ„¢ Diagnostic Exchange application. (codemap.com)
- Rapid influenza diagnostic tests (RIDTs) are immunoassays that can identify the presence of influenza A and B viral nucleoprotein antigens in respiratory specimens, and display the result in a qualitative way (positive vs. negative) (1). (cdc.gov)
- Testing Methods" and "Table 2: Characteristics of Rapid Influenza Diagnostic Tests" . (cdc.gov)
Search1
- You may search on this page for a test by disorder. (cincinnatichildrens.org)
Medication1
- The A1C test also helps providers adjust medication for people with diabetes to reduce the risk of long-term complications. (nih.gov)
PrismRA2
- PrismRA is the leading molecular signature test to help guide personalized therapy selection for rheumatoid arthritis. (b3cnewswire.com)
- From a routine blood draw, the PrismRA test analyzes an individual's molecular signature, helping identify who is unlikely to adequately respond to TNFi therapy, the world's largest selling drug class, so non-responders can be prescribed alternative effective therapy. (b3cnewswire.com)
Detect influenza1
- Known for its xMAP technology (see "Flu Redux," CLP, August 2011, page 17), in July 2011 Luminex received FDA clearance for its Respiratory Viral Panel FAST test (xTAG RVP FAST) to detect influenza A/B, hMPV, RSV, adenovirus, and rhinovirus. (clpmag.com)
Procedures3
- Further studies highlighted the financial strain of medical overuse, such as the analysis conducted by the Institute of Medicine, which found that up to 30% of American health care spending is on unnecessary tests and procedures. (wikipedia.org)
- He is a professional who tests body tissues and fluids using medical procedures that he learns during bachelors' degree. (bitrebels.com)
- The sample is tested with a number of complicated procedures one after the other that accurately provide the result. (bitrebels.com)
Diabetes8
- A new fact sheet from the National Institutes of Health explains the A1C test, a widely used and important test to diagnose type 2 diabetes and prediabetes, and to monitor blood glucose levels of people with type 1 and type 2 diabetes. (nih.gov)
- Originally, the A1C test had been recommended only for monitoring diabetes. (nih.gov)
- But in 2009, an international committee of experts convened by the American Diabetes Association, International Diabetes Federation and European Association for the Study of Diabetes recommended expanding the use of the test to include diagnosing type 2 diabetes and prediabetes. (nih.gov)
- Experts hope the ease of A1C testing will encourage more people to be checked for prediabetes and type 2 diabetes. (nih.gov)
- The standard blood glucose tests for diagnosing type 2 diabetes and prediabetes - the fasting plasma glucose test and the oral glucose tolerance test (OGTT) - measure blood glucose in a person who has not eaten anything for at least eight hours. (nih.gov)
- We hope the convenience of the A1C test will encourage more people to be tested for prediabetes and diabetes. (nih.gov)
- If you are at least 45 years old, or younger than 45 and are overweight, inactive, and have at least one risk factor for type 2 diabetes, consider being tested for the disease. (nih.gov)
- The fact sheet, The A1C Test and Diabetes, is available from NIDDK's National Diabetes Information Clearinghouse at www.diabetes.niddk.nih.gov/dm/pubs/A1CTest . (nih.gov)
Hematocrit1
- Hematocrit testing is suggested if excessive bleeding with concomitant anemia is suspected. (medscape.com)
Serum1
- Tests to measure the concentration of substances in the blood may use plasma, serum, or whole blood that has been anticoagulated to keep all the contents in suspension. (britannica.com)
Evaluation2
- Nurses must attend the webinars, complete at least one hour of learning, submit the online evaluation form, and complete the online post-test to earn credit. (schoolandyouth.org)
- Testing your iron level is an essential part of your hematologic evaluation. (anylabtestnow.com)
Cells1
- Blood count tests measure the number and types of cells in your blood. (medlineplus.gov)
Additional2
- Receive newsletters, testing offers, and additional information in your inbox every month. (anylabtestnow.com)
- Not only do these tests reduce the time from sample to answer significantly, the accuracy of these tests eliminates the need for additional confirmatory testing. (clpmag.com)
Complete1
- Considered eligible for curative intent surgery (complete resection with all surgical margins testing negative for tumor). (who.int)
Negative1
- Stage I to Stage IIIA with all surgical margins testing negative for tumor. (who.int)
Found2
- In 2017, a joint report between Choosing Wisely Canada and the Canadian Institute for Health Information found up to 30% of tests and treatments were unnecessary based on eight campaign recommendations. (wikipedia.org)
- A pre-surgery blood test found a hematologic problem for this then-53-year-old person who considered himself perfectly healthy. (iwmf.com)
Anemia1
- With hematologic testing, it was discovered that the patient had iron-deficiency anemia. (rdhmag.com)
Treatments1
- They use a variety of tests and treatments for these issues. (medicalnewstoday.com)
Iron1
- The test result will provide a numeric value of the iron level in your body. (anylabtestnow.com)