Disorders of the blood and blood forming tissues.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Surgical procedure involving either partial or entire removal of the spleen.
Formation of stones in any part of the URINARY TRACT, usually in the KIDNEY; URINARY BLADDER; or the URETER.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Infections with fungi of the genus ASPERGILLUS.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon. (1/1031)

OBJECTIVE: To investigate haematological variations and iron related changes in the serum of participants in a 1600 kilometre ultramarathon run. PARTICIPANTS: Seven male and two female participants in a 1600 km foot race. METHODS: Blood samples were obtained from the participants before, after four and 11 days of running, and at the end of the event. Samples were analysed by standard methods for haemoglobin, packed cell volume, total red cell count, mean red cell volume, mean red cell haemoglobin, total white cell count and differential, platelets, reticulocytes, iron, ferritin, total iron binding capacity, percentage transferrin saturation, haptoglobin, and bilirubin and corrected for changes in plasma volume. RESULTS: The following variables decreased during the event (p < 0.05): haemoglobin, packed cell volume, mean red cell volume, percentage lymphocytes, percentage monocytes, serum iron, total iron binding capacity, and percentage transferrin saturation. Increases (p < 0.05) were found in plasma volume, total red cell count (day 4 only), total white cell count, percentage and absolute numbers of neutrophils and reticulocytes, absolute numbers of lymphocytes and monocytes (day 4 only), absolute numbers of eosinophils (day 11 and race end), absolute numbers of basophils (race end only), platelets, ferritin, haptoglobin, and bilirubin (day 4 only). CONCLUSION: Ultramarathon running is associated with a wide range of changes in haematological parameters, many of which are related to the normal acute phase response to injury. These should not be confused with indicators of disease.  (+info)

Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. (2/1031)

PURPOSE: To evaluate the activity and toxicity of the combination of cisplatin (80 mg/m2 day 1) and vinorelbine (25 mg/m2 days 1 and 8) in patients with carcinoma of the uterine cervix that has not been previously treated with chemotherapy. PATIENTS AND METHODS: Fifty patients with cervical cancer were enrolled onto this study (27 stage IB-III, 23 stage IVB-recurrent). A two-stage optimal Simon design was applied. Thirteen responders of 29 treated patients were required to proceed beyond the first stage, and 28 responders were needed overall. RESULTS: Hematologic toxicity was mild, with neutropenia being the most frequent side effect. Nonhematologic toxicity was frequent but never severe; one patient had grade 3 peripheral neurotoxicity. Objective responses were recorded for 32 patients (64%): 11 patients (22%) achieved a complete response (CR) and 21 patients (42%) achieved a partial response (PR). The response rate was 81.5% in patients with IB-III stage (25.9% CR rate) and 43.5% in patients with IVB-recurrent disease (17.4% CR rate). Responses were seen both in stage IVB patients (one CR and two PRs, for an overall rate of 37.5%) and in patients with recurrent disease (three CRs + four PRs, for an overall rate of 46.7%). CONCLUSION: The combination of cisplatin and vinorelbine is an active regimen in the treatment of patients with early-stage and advanced carcinoma of the uterine cervix. The hematologic and nonhematologic toxicity of this combination is mild.  (+info)

Phase II trial of paclitaxel and cisplatin in metastatic and recurrent carcinoma of the uterine cervix. (3/1031)

PURPOSE: Both paclitaxel and cisplatin have moderate activity in patients with metastatic or recurrent cancer of the cervix, and the combination of these two agents has shown activity and possible synergism in a variety of solid tumors. We administered this combination to patients with metastatic or recurrent cervical cancer to evaluate its activity. PATIENTS AND METHODS: Thirty-four consecutive patients were treated on an outpatient basis with paclitaxel 175 mg/m2 administered intravenously over a 3-hour period followed by cisplatin 75 mg/m2 administered intravenously with granulocyte colony-stimulating factor support. The chemotherapy was administered every 3 weeks for a maximum of six courses. RESULTS: Sixteen patients (47%; 95% confidence interval, 30% to 65%) achieved an objective response, including five complete responses and 11 partial responses. Responses occurred in 28% of patients with disease within the radiation field only and in 57% of patients with disease involving other sites. The median duration of response was 5.5 months, and the median times to progression and survival for all patients were 5 and 9 months, respectively. Grade 3 or 4 toxicities included anemia in 18% of patients and granulocytopenia in 15% of patients. Fifty-three percent of patients developed some degree of neurotoxicity; 21% of cases were grade 2 or worse. CONCLUSION: The combination of paclitaxel with cisplatin seems relatively well tolerated and moderately active in patients with metastatic or recurrent cervical cancer. The significant incidence of neurotoxicity is of concern, and alternative methods of administration of the two agents could be evaluated. Then, further study of this combination, alone or with the addition of other active agents, is warranted.  (+info)

Combined irinotecan and oxaliplatin plus granulocyte colony-stimulating factor in patients with advanced fluoropyrimidine/leucovorin-pretreated colorectal cancer. (4/1031)

PURPOSE: To evaluate the efficacy and tolerance of combined irinotecan and oxaliplatin in patients with advanced colorectal cancer pretreated with leucovorin-modulated fluoropyrimidines. PATIENTS AND METHODS: Thirty-six patients with metastatic colorectal cancer, who progressed while receiving or within 6 months after discontinuing palliative chemotherapy with fluoropyrimidines/leucovorin, were enrolled onto this study. Treatment consisted of oxaliplatin 85 mg/m2 on days 1 + 15 and irinotecan 80 mg/m2 on days 1 + 8 + 15 every 4 weeks. Depending on the absolute neutrophil counts (ANC) on the day of scheduled chemotherapeutic drug administration, a 5-day course of granulocyte colony-stimulating factor (G-CSF) 5 microg/kg/d was given. RESULTS: The overall response rate was 42% for all 36 assessable patients (95% confidence interval, 26% to 59%), including two complete remissions (6%). Thirteen additional patients (36%) had stable disease, and only eight (22%) progressed. The median time to treatment failure was 7.5 months (range, 1 to 13.5+ months). After a median follow-up time of 14 months, 19 patients (53%) are still alive. Hematologic toxicity was commonly observed, although according to the ANC-adapted use of G-CSF (in 31 patients during 81 of 174 courses), it was generally mild: grade 3 and 4 granulocytopenia occurred in only five and two cases, respectively. The most frequent nonhematologic adverse reactions were nausea/emesis and diarrhea, which were rated severe in 17% and 19%, respectively. CONCLUSION: Our data suggest that the combination of irinotecan and oxaliplatin with or without G-CSF has substantial antitumor activity in patients with progressive fluoropyrimidine/leucovorin-pretreated colorectal cancer. Overall toxicity was modest, with gastrointestinal symptoms constituting the dose-limiting side effects. Further evaluation of this regimen seems warranted.  (+info)

Front-line treatment of advanced non-small-cell lung cancer with docetaxel and gemcitabine: a multicenter phase II trial. (5/1031)

PURPOSE: To evaluate the tolerance and efficacy of the combination of docetaxel and gemcitabine in patients with advanced non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Fifty-one chemotherapy-naive patients with NSCLC were treated with gemcitabine 900 mg/m2 intravenously on days 1 and 8 and docetaxel 100 mg/m2 intravenously on day 8 with granulocyte colony-stimulating factor (150 microg/m2, subcutaneously) support from day 9 to day 15. Treatment was repeated every 3 weeks. RESULTS: The patients' median age was 64 years. The World Health Organization performance status was 0 to 1 in 39 patients and 2 in 12 patients. Fifteen patients (29%) had stage IIIB disease, and 36 (71%) had stage IV; histology was mainly squamous cell carcinoma (59%). A partial response was achieved in 19 patients (37.5%; 95% confidence interval, 24% to 50%); stable disease and progressive disease were each observed in 16 patients (31.4%). The median duration of response and the time to tumor progression were 5 and 6 months, respectively. The median survival was 13 months, and the actuarial 1-year survival was 50.7%. Grade 4 anemia and thrombocytopenia were rare (2%). Four patients (8%) developed grade 3 or 4 neutropenia, and all were complicated with fever; there was no treatment-related death. Grade 3 or 4 diarrhea occurred in three patients (6%), grade 2 or 3 neurotoxicity in four patients (8%), grade 2 or 3 asthenia in 10 patients (20%), and grade 2 or 3 edema in 10 patients (20%). CONCLUSION: The combination of docetaxel/gemcitabine is well tolerated, can be used for outpatients, and is active for the treatment of advanced NSCLC. This treatment merits further comparison with other cisplatin- or carboplatin-based combinations.  (+info)

Paclitaxel and carboplatin in the treatment of small-cell lung cancer patients resistant to cyclophosphamide, doxorubicin, and etoposide: a non-cross-resistant schedule. (6/1031)

PURPOSE: To evaluate the efficacy of paclitaxel and carboplatin (PC) in small-cell lung cancer (SCLC) patients resistant to cyclophosphamide, doxorubicin, and etoposide (CDE). PATIENTS AND METHODS: We performed a phase II study with PC in SCLC patients who relapsed within 3 months after first-line treatment with CDE. Paclitaxel administration (175 mg/m2 by a 3-hour intravenous infusion) was followed by a 30-minute infusion of carboplatin (area under the curve 7; Chatelut formula) once every 3 weeks for five cycles. Dexamethasone, clemastine, and ranitidine were standard premedication before every cycle. RESULTS: Included were 35 patients (median age, 59 years; 16 with limited disease and 19 with extensive disease; Eastern Cooperative Oncology Group performance status of < or = 1; median time off treatment 6 weeks) who were previously treated with CDE (n = 33), oral etoposide (n = 2), and reinduction CDE (n = 15); only one patient had received three CDE treatments of five cycles. The CDE regimen was followed by local thoracic radiotherapy in seven patients. Hematologic toxicity of grade 3 or 4, for leukopenia was 27% and 6%, for thrombocytopenia 21% and 13%, and for anemia 17% and 0%, respectively, for a total of 132 cycles. Two patients had neutropenic fever; no toxic death occurred. Nonhematologic toxicity was paresthesia CTC grade 3, diarrhea grade 4, and myalgia grade 3 in one patient each. Reversible paresthesia (CTC grade 1 and 2) in toes and fingers was reported in 69% of patients. Thirty-four patients were assessable for response: complete response in two patients, partial response in 23 patients, stable disease in eight patients, and progressive disease in one patient (response rate, 73.5%; 95% confidence interval, 59% to 88%). One patient was found to have atypical carcinoid at pathologic review and was excluded. Median time to progression was 21 weeks (range, 3 to 40 weeks). Median survival was 31 weeks (range, 6 to 112 weeks). One-year survival was 9%. CONCLUSION: Second-line PC in CDE-resistant SCLC patients yields a high response rate and seems non-cross-resistant to CDE. Toxicity was mild in these poor-prognosis patients.  (+info)

Phase II trial of primary chemotherapy followed by reduced-dose radiation for CNS germ cell tumors. (7/1031)

PURPOSE: A prospective phase II study was initiated to assess the response rate, survival, and late effects of treatment in patients with newly diagnosed CNS germ cell tumors (GCT), using etoposide plus cisplatin followed by radiation therapy prescribed by extent of disease, histology, and response to chemotherapy. PATIENTS AND METHODS: Seventeen patients aged 8 to 24 years with histologically proven CNS GCT received etoposide (100 mg/m2/d) plus cisplatin (20 mg/m2/d) daily for 5 days every 3 weeks for four cycles, followed by radiation therapy. Nine patients had germinomas; eight had mixed GCT. Four patients (three with germinomas and one with mixed GCT) presented with leptomeningeal dissemination. RESULTS: Radiographically, 14 of 17 patients were assessable for response; 11 patients experienced complete regression, and three had major partial regression before radiation. Six of seven assessable patients with elevated CSF levels of alpha-fetoprotein or betahuman chorionic gonadotropin had normalization with chemotherapy alone; all normalized with combined chemotherapy and radiation therapy. All 17 patients are alive without evidence of disease (median follow-up, 51 months). One patient developed a relapse in the spinal leptomeninges and was rendered free of disease with spinal radiation more than 5 years ago. One patient developed carotid stenosis requiring surgery. Thus far, only minimal long-term deterioration in neurocognitive function has been detected as a consequence of protocol treatment. CONCLUSION: Conventional-dose intravenous chemotherapy with etoposide and cisplatin can effect tumor regression in a high proportion of patients with CNS GCT, including those with leptomeningeal metastases. Acute and long-term toxicities are acceptable. Progression-free survival and overall survival are excellent.  (+info)

Phase I trial of docetaxel with estramustine in androgen-independent prostate cancer. (8/1031)

PURPOSE: To evaluate the toxicity, efficacy, and pharmacokinetics of docetaxel when combined with oral estramustine and dexamethasone in a phase I study in patients with progressive metastatic androgen-independent prostate cancer. PATIENTS AND METHODS: Thirty-four men were stratified into minimally pretreated (MPT) and extensively pretreated (EPT) groups. Estramustine 280 mg PO tid was administered 1 hour before or 2 hours after meals on days 1 through 5, with escalated doses of docetaxel from 40 to 80 mg/m2 on day 2. Treatment was repeated every 21 days. RESULTS: Thirty-four patients were assessable for toxicity and 33 for response. In the MPT patients, dose-limiting myelosuppression was reached at 80 mg/m2, with six patients experiencing grade 3/4 granulocytopenia. In EPT patients, escalation above 70 mg/m2 was not attempted. Fourteen MPT (70%) and six EPT (50%) patients had a > or = 50% decline in serum PSA on two consecutive measurements taken at least 2 weeks apart. The overall 50% PSA response rate was 63% (95% confidence interval [CI], 28% to 81%). Of the 18 patients with bidimensionally measurable disease, five (28%; 95% CI, 11% to 54%) achieved a partial response. At the time of entry onto the study, 15 patients required narcotic analgesics for bone pain; after treatment, eight (53%) discontinued their pain medications. The area under the curve for docetaxel increased linearly from 40 to 70 mg/m2. At 80 mg/m2, the measured area under the curve was 8.37 (standard deviation, 0.724), which was significantly higher than the previously reported values. CONCLUSION: The recommended phase II dose of docetaxel combined with estramustine is 70 mg/m2 in MPT patients and 60 mg/m2 in EPT patients. This combination is active in men with androgen-independent prostate cancer.  (+info)

Hematologic diseases, also known as hematological disorders, refer to a group of conditions that affect the production, function, or destruction of blood cells or blood-related components, such as plasma. These diseases can affect erythrocytes (red blood cells), leukocytes (white blood cells), and platelets (thrombocytes), as well as clotting factors and hemoglobin.

Hematologic diseases can be broadly categorized into three main types:

1. Anemia: A condition characterized by a decrease in the total red blood cell count, hemoglobin, or hematocrit, leading to insufficient oxygen transport to tissues and organs. Examples include iron deficiency anemia, sickle cell anemia, and aplastic anemia.
2. Leukemia and other disorders of white blood cells: These conditions involve the abnormal production or function of leukocytes, which can lead to impaired immunity and increased susceptibility to infections. Examples include leukemias (acute lymphoblastic leukemia, chronic myeloid leukemia), lymphomas, and myelodysplastic syndromes.
3. Platelet and clotting disorders: These diseases affect the production or function of platelets and clotting factors, leading to abnormal bleeding or clotting tendencies. Examples include hemophilia, von Willebrand disease, thrombocytopenia, and disseminated intravascular coagulation (DIC).

Hematologic diseases can have various causes, including genetic defects, infections, autoimmune processes, environmental factors, or malignancies. Proper diagnosis and management of these conditions often require the expertise of hematologists, who specialize in diagnosing and treating disorders related to blood and its components.

Hematologic neoplasms, also known as hematological malignancies, are a group of diseases characterized by the uncontrolled growth and accumulation of abnormal blood cells or bone marrow cells. These disorders can originate from the myeloid or lymphoid cell lines, which give rise to various types of blood cells, including red blood cells, white blood cells, and platelets.

Hematologic neoplasms can be broadly classified into three categories:

1. Leukemias: These are cancers that primarily affect the bone marrow and blood-forming tissues. They result in an overproduction of abnormal white blood cells, which interfere with the normal functioning of the blood and immune system. There are several types of leukemia, including acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML).
2. Lymphomas: These are cancers that develop from the lymphatic system, which is a part of the immune system responsible for fighting infections. Lymphomas can affect lymph nodes, spleen, bone marrow, and other organs. The two main types of lymphoma are Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL).
3. Myelomas: These are cancers that arise from the plasma cells, a type of white blood cell responsible for producing antibodies. Multiple myeloma is the most common type of myeloma, characterized by an excessive proliferation of malignant plasma cells in the bone marrow, leading to the production of abnormal amounts of monoclonal immunoglobulins (M proteins) and bone destruction.

Hematologic neoplasms can have various symptoms, such as fatigue, weakness, frequent infections, easy bruising or bleeding, weight loss, swollen lymph nodes, and bone pain. The diagnosis typically involves a combination of medical history, physical examination, laboratory tests, imaging studies, and sometimes bone marrow biopsy. Treatment options depend on the type and stage of the disease and may include chemotherapy, radiation therapy, targeted therapy, immunotherapy, stem cell transplantation, or a combination of these approaches.

A splenectomy is a surgical procedure in which the spleen is removed from the body. The spleen is an organ located in the upper left quadrant of the abdomen, near the stomach and behind the ribs. It plays several important roles in the body, including fighting certain types of infections, removing old or damaged red blood cells from the circulation, and storing platelets and white blood cells.

There are several reasons why a splenectomy may be necessary, including:

* Trauma to the spleen that cannot be repaired
* Certain types of cancer, such as Hodgkin's lymphoma or non-Hodgkin's lymphoma
* Sickle cell disease, which can cause the spleen to enlarge and become damaged
* A ruptured spleen, which can be life-threatening if not treated promptly
* Certain blood disorders, such as idiopathic thrombocytopenic purpura (ITP) or hemolytic anemia

A splenectomy is typically performed under general anesthesia and may be done using open surgery or laparoscopically. After the spleen is removed, the incision(s) are closed with sutures or staples. Recovery time varies depending on the individual and the type of surgery performed, but most people are able to return to their normal activities within a few weeks.

It's important to note that following a splenectomy, individuals may be at increased risk for certain types of infections, so it's recommended that they receive vaccinations to help protect against these infections. They should also seek medical attention promptly if they develop fever, chills, or other signs of infection.

Urolithiasis is the formation of stones (calculi) in the urinary system, which includes the kidneys, ureters, bladder, and urethra. These stones can be composed of various substances such as calcium oxalate, calcium phosphate, uric acid, or struvite. The presence of urolithiasis can cause symptoms like severe pain in the back or side, nausea, vomiting, fever, and blood in the urine. The condition can be managed with medications, increased fluid intake, and in some cases, surgical intervention may be required to remove the stones.

Leukemia is a type of cancer that originates from the bone marrow - the soft, inner part of certain bones where new blood cells are made. It is characterized by an abnormal production of white blood cells, known as leukocytes or blasts. These abnormal cells accumulate in the bone marrow and interfere with the production of normal blood cells, leading to a decrease in red blood cells (anemia), platelets (thrombocytopenia), and healthy white blood cells (leukopenia).

There are several types of leukemia, classified based on the specific type of white blood cell affected and the speed at which the disease progresses:

1. Acute Leukemias - These types of leukemia progress rapidly, with symptoms developing over a few weeks or months. They involve the rapid growth and accumulation of immature, nonfunctional white blood cells (blasts) in the bone marrow and peripheral blood. The two main categories are:
- Acute Lymphoblastic Leukemia (ALL) - Originates from lymphoid progenitor cells, primarily affecting children but can also occur in adults.
- Acute Myeloid Leukemia (AML) - Develops from myeloid progenitor cells and is more common in older adults.

2. Chronic Leukemias - These types of leukemia progress slowly, with symptoms developing over a period of months to years. They involve the production of relatively mature, but still abnormal, white blood cells that can accumulate in large numbers in the bone marrow and peripheral blood. The two main categories are:
- Chronic Lymphocytic Leukemia (CLL) - Affects B-lymphocytes and is more common in older adults.
- Chronic Myeloid Leukemia (CML) - Originates from myeloid progenitor cells, characterized by the presence of a specific genetic abnormality called the Philadelphia chromosome. It can occur at any age but is more common in middle-aged and older adults.

Treatment options for leukemia depend on the type, stage, and individual patient factors. Treatments may include chemotherapy, targeted therapy, immunotherapy, stem cell transplantation, or a combination of these approaches.

Aplastic anemia is a medical condition characterized by pancytopenia (a decrease in all three types of blood cells: red blood cells, white blood cells, and platelets) due to the failure of bone marrow to produce new cells. It is called "aplastic" because the bone marrow becomes hypocellular or "aplastic," meaning it contains few or no blood-forming stem cells.

The condition can be acquired or inherited, with acquired aplastic anemia being more common. Acquired aplastic anemia can result from exposure to toxic chemicals, radiation, drugs, viral infections, or autoimmune disorders. Inherited forms of the disease include Fanconi anemia and dyskeratosis congenita.

Symptoms of aplastic anemia may include fatigue, weakness, shortness of breath, pale skin, easy bruising or bleeding, frequent infections, and fever. Treatment options for aplastic anemia depend on the severity of the condition and its underlying cause. They may include blood transfusions, immunosuppressive therapy, and stem cell transplantation.

Myelodysplastic syndromes (MDS) are a group of diverse bone marrow disorders characterized by dysplasia (abnormal development or maturation) of one or more types of blood cells or by ineffective hematopoiesis, resulting in cytopenias (lower than normal levels of one or more types of blood cells). MDS can be classified into various subtypes based on the number and type of cytopenias, the degree of dysplasia, the presence of ring sideroblasts, and cytogenetic abnormalities.

The condition primarily affects older adults, with a median age at diagnosis of around 70 years. MDS can evolve into acute myeloid leukemia (AML) in approximately 30-40% of cases. The pathophysiology of MDS involves genetic mutations and chromosomal abnormalities that lead to impaired differentiation and increased apoptosis of hematopoietic stem and progenitor cells, ultimately resulting in cytopenias and an increased risk of developing AML.

The diagnosis of MDS typically requires a bone marrow aspiration and biopsy, along with cytogenetic and molecular analyses to identify specific genetic mutations and chromosomal abnormalities. Treatment options for MDS depend on the subtype, severity of cytopenias, and individual patient factors. These may include supportive care measures, such as transfusions and growth factor therapy, or more aggressive treatments, such as chemotherapy and stem cell transplantation.

Graft-versus-host disease (GVHD) is a condition that can occur after an allogeneic hematopoietic stem cell transplantation (HSCT), where the donated immune cells (graft) recognize the recipient's tissues (host) as foreign and attack them. This results in inflammation and damage to various organs, particularly the skin, gastrointestinal tract, and liver.

Acute GVHD typically occurs within 100 days of transplantation and is characterized by symptoms such as rash, diarrhea, and liver dysfunction. Chronic GVHD, on the other hand, can occur after 100 days or even years post-transplant and may present with a wider range of symptoms, including dry eyes and mouth, skin changes, lung involvement, and issues with mobility and flexibility in joints.

GVHD is a significant complication following allogeneic HSCT and can have a substantial impact on the patient's quality of life and overall prognosis. Preventative measures, such as immunosuppressive therapy, are often taken to reduce the risk of GVHD, but its management remains a challenge in transplant medicine.

Bone marrow transplantation (BMT) is a medical procedure in which damaged or destroyed bone marrow is replaced with healthy bone marrow from a donor. Bone marrow is the spongy tissue inside bones that produces blood cells. The main types of BMT are autologous, allogeneic, and umbilical cord blood transplantation.

In autologous BMT, the patient's own bone marrow is used for the transplant. This type of BMT is often used in patients with lymphoma or multiple myeloma who have undergone high-dose chemotherapy or radiation therapy to destroy their cancerous bone marrow.

In allogeneic BMT, bone marrow from a genetically matched donor is used for the transplant. This type of BMT is often used in patients with leukemia, lymphoma, or other blood disorders who have failed other treatments.

Umbilical cord blood transplantation involves using stem cells from umbilical cord blood as a source of healthy bone marrow. This type of BMT is often used in children and adults who do not have a matched donor for allogeneic BMT.

The process of BMT typically involves several steps, including harvesting the bone marrow or stem cells from the donor, conditioning the patient's body to receive the new bone marrow or stem cells, transplanting the new bone marrow or stem cells into the patient's body, and monitoring the patient for signs of engraftment and complications.

BMT is a complex and potentially risky procedure that requires careful planning, preparation, and follow-up care. However, it can be a life-saving treatment for many patients with blood disorders or cancer.

An immunocompromised host refers to an individual who has a weakened or impaired immune system, making them more susceptible to infections and decreased ability to fight off pathogens. This condition can be congenital (present at birth) or acquired (developed during one's lifetime).

Acquired immunocompromised states may result from various factors such as medical treatments (e.g., chemotherapy, radiation therapy, immunosuppressive drugs), infections (e.g., HIV/AIDS), chronic diseases (e.g., diabetes, malnutrition, liver disease), or aging.

Immunocompromised hosts are at a higher risk for developing severe and life-threatening infections due to their reduced immune response. Therefore, they require special consideration when it comes to prevention, diagnosis, and treatment of infectious diseases.

Homologous transplantation is a type of transplant surgery where organs or tissues are transferred between two genetically non-identical individuals of the same species. The term "homologous" refers to the similarity in structure and function of the donated organ or tissue to the recipient's own organ or tissue.

For example, a heart transplant from one human to another is an example of homologous transplantation because both organs are hearts and perform the same function. Similarly, a liver transplant, kidney transplant, lung transplant, and other types of organ transplants between individuals of the same species are also considered homologous transplantations.

Homologous transplantation is in contrast to heterologous or xenogeneic transplantation, where organs or tissues are transferred from one species to another, such as a pig heart transplanted into a human. Homologous transplantation is more commonly performed than heterologous transplantation due to the increased risk of rejection and other complications associated with xenogeneic transplants.

Aspergillosis is a medical condition that is caused by the infection of the Aspergillus fungi. This fungus is commonly found in decaying organic matter, such as leaf litter and compost piles, and can also be found in some indoor environments like air conditioning systems and old buildings with water damage.

There are several types of aspergillosis, including:

1. Allergic bronchopulmonary aspergillosis (ABPA): This type of aspergillosis occurs when a person's immune system overreacts to the Aspergillus fungi, causing inflammation in the airways and lungs. ABPA is often seen in people with asthma or cystic fibrosis.
2. Invasive aspergillosis: This is a serious and potentially life-threatening condition that occurs when the Aspergillus fungi invade the bloodstream and spread to other organs, such as the brain, heart, or kidneys. Invasive aspergillosis typically affects people with weakened immune systems, such as those undergoing chemotherapy or organ transplantation.
3. Aspergilloma: Also known as a "fungus ball," an aspergilloma is a growth of the Aspergillus fungi that forms in a preexisting lung cavity, such as one caused by previous lung disease or injury. While an aspergilloma itself is not typically harmful, it can cause symptoms like coughing up blood or chest pain if it grows too large or becomes infected.

Symptoms of aspergillosis can vary depending on the type and severity of the infection. Treatment may include antifungal medications, surgery to remove the fungal growth, or management of underlying conditions that increase the risk of infection.

Hematopoietic Stem Cell Transplantation (HSCT) is a medical procedure where hematopoietic stem cells (immature cells that give rise to all blood cell types) are transplanted into a patient. This procedure is often used to treat various malignant and non-malignant disorders affecting the hematopoietic system, such as leukemias, lymphomas, multiple myeloma, aplastic anemia, inherited immune deficiency diseases, and certain genetic metabolic disorders.

The transplantation can be autologous (using the patient's own stem cells), allogeneic (using stem cells from a genetically matched donor, usually a sibling or unrelated volunteer), or syngeneic (using stem cells from an identical twin).

The process involves collecting hematopoietic stem cells, most commonly from the peripheral blood or bone marrow. The collected cells are then infused into the patient after the recipient's own hematopoietic system has been ablated (or destroyed) using high-dose chemotherapy and/or radiation therapy. This allows the donor's stem cells to engraft, reconstitute, and restore the patient's hematopoietic system.

HSCT is a complex and potentially risky procedure with various complications, including graft-versus-host disease, infections, and organ damage. However, it offers the potential for cure or long-term remission in many patients with otherwise fatal diseases.

Bone marrow is the spongy tissue found inside certain bones in the body, such as the hips, thighs, and vertebrae. It is responsible for producing blood-forming cells, including red blood cells, white blood cells, and platelets. There are two types of bone marrow: red marrow, which is involved in blood cell production, and yellow marrow, which contains fatty tissue.

Red bone marrow contains hematopoietic stem cells, which can differentiate into various types of blood cells. These stem cells continuously divide and mature to produce new blood cells that are released into the circulation. Red blood cells carry oxygen throughout the body, white blood cells help fight infections, and platelets play a crucial role in blood clotting.

Bone marrow also serves as a site for immune cell development and maturation. It contains various types of immune cells, such as lymphocytes, macrophages, and dendritic cells, which help protect the body against infections and diseases.

Abnormalities in bone marrow function can lead to several medical conditions, including anemia, leukopenia, thrombocytopenia, and various types of cancer, such as leukemia and multiple myeloma. Bone marrow aspiration and biopsy are common diagnostic procedures used to evaluate bone marrow health and function.

Antifungal agents are a type of medication used to treat and prevent fungal infections. These agents work by targeting and disrupting the growth of fungi, which include yeasts, molds, and other types of fungi that can cause illness in humans.

There are several different classes of antifungal agents, including:

1. Azoles: These agents work by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. Examples of azole antifungals include fluconazole, itraconazole, and voriconazole.
2. Echinocandins: These agents target the fungal cell wall, disrupting its synthesis and leading to fungal cell death. Examples of echinocandins include caspofungin, micafungin, and anidulafungin.
3. Polyenes: These agents bind to ergosterol in the fungal cell membrane, creating pores that lead to fungal cell death. Examples of polyene antifungals include amphotericin B and nystatin.
4. Allylamines: These agents inhibit squalene epoxidase, a key enzyme in ergosterol synthesis. Examples of allylamine antifungals include terbinafine and naftifine.
5. Griseofulvin: This agent disrupts fungal cell division by binding to tubulin, a protein involved in fungal cell mitosis.

Antifungal agents can be administered topically, orally, or intravenously, depending on the severity and location of the infection. It is important to use antifungal agents only as directed by a healthcare professional, as misuse or overuse can lead to resistance and make treatment more difficult.

Acute myeloid leukemia (AML) is a type of cancer that originates in the bone marrow, the soft inner part of certain bones where new blood cells are made. In AML, the immature cells, called blasts, in the bone marrow fail to mature into normal blood cells. Instead, these blasts accumulate and interfere with the production of normal blood cells, leading to a shortage of red blood cells (anemia), platelets (thrombocytopenia), and normal white blood cells (leukopenia).

AML is called "acute" because it can progress quickly and become severe within days or weeks without treatment. It is a type of myeloid leukemia, which means that it affects the myeloid cells in the bone marrow. Myeloid cells are a type of white blood cell that includes monocytes and granulocytes, which help fight infection and defend the body against foreign invaders.

In AML, the blasts can build up in the bone marrow and spread to other parts of the body, including the blood, lymph nodes, liver, spleen, and brain. This can cause a variety of symptoms, such as fatigue, fever, frequent infections, easy bruising or bleeding, and weight loss.

AML is typically treated with a combination of chemotherapy, radiation therapy, and/or stem cell transplantation. The specific treatment plan will depend on several factors, including the patient's age, overall health, and the type and stage of the leukemia.

Retrospective studies, also known as retrospective research or looking back studies, are a type of observational study that examines data from the past to draw conclusions about possible causal relationships between risk factors and outcomes. In these studies, researchers analyze existing records, medical charts, or previously collected data to test a hypothesis or answer a specific research question.

Retrospective studies can be useful for generating hypotheses and identifying trends, but they have limitations compared to prospective studies, which follow participants forward in time from exposure to outcome. Retrospective studies are subject to biases such as recall bias, selection bias, and information bias, which can affect the validity of the results. Therefore, retrospective studies should be interpreted with caution and used primarily to generate hypotheses for further testing in prospective studies.

Transplantation conditioning, also known as preparative regimen or immunoablative therapy, refers to the use of various treatments prior to transplantation of cells, tissues or organs. The main goal of transplantation conditioning is to suppress the recipient's immune system, allowing for successful engraftment and minimizing the risk of rejection of the donor tissue.

There are two primary types of transplantation conditioning: myeloablative and non-myeloablative.

1. Myeloablative conditioning is a more intensive regimen that involves the use of high-dose chemotherapy, radiation therapy or both. This approach eliminates not only immune cells but also stem cells in the bone marrow, requiring the recipient to receive a hematopoietic cell transplant (HCT) from the donor to reconstitute their blood and immune system.
2. Non-myeloablative conditioning is a less intensive regimen that primarily targets immune cells while sparing the stem cells in the bone marrow. This approach allows for mixed chimerism, where both recipient and donor immune cells coexist, reducing the risk of severe complications associated with myeloablative conditioning.

The choice between these two types of transplantation conditioning depends on various factors, including the type of transplant, patient's age, overall health, and comorbidities. Both approaches carry risks and benefits, and the decision should be made carefully by a multidisciplinary team of healthcare professionals in consultation with the patient.

Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.

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The Hematologic Diseases Information Service is a part of the NIDDK's Division of Kidney, Urologic, and Hematologic Diseases. ... The Hematologic Diseases Information Service is an information dissemination service of the National Institute of Diabetes and ... Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health, which is part of the U.S. ... http://hematologic.niddk.nih.gov/ v t e (Articles lacking sources from July 2019, All articles lacking sources, All stub ...
"Hematologic manifestations of celiac disease". Blood. 109 (2): 412-421. doi:10.1182/blood-2006-07-031104. PMC 1785098. PMID ... Autosplenectomy caused by sickle cell anemia or hyposplenism in coeliac disease In patients with obstructive liver disease, ... Alpha-thalassemia and beta-thalassemia Hemoglobin C Disease Iron deficiency anemia Post-splenectomy: A major function of the ... Target cells may appear in association with the following conditions: Liver disease: Lecithin-cholesterol acyltransferase (LCAT ...
Halfdanarson, T. R.; Litzow, M. R.; Murray, J. A. (15 January 2007). "Hematologic manifestations of celiac disease". Blood. 109 ... Due to underlying diseases that destroy the spleen (autosplenectomy), e.g. sickle-cell disease. Celiac disease: unknown ... Functional asplenia occurs when splenic tissue is present but does not work well (e.g. sickle-cell disease, polysplenia) -such ... Ferguson, Anne; Hutton, MargaretM.; Maxwell, J.D.; Murray, D. (January 1970). "Adult Cœlicac Diseases in Hyposplenic Patients ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ... The disease is regarded as a uniformly genetic disease although the genes causing it have not been identified in ~30% of cases ... D218Y: familial disease similar to but more severe that the disease cause by G209S and D218G mutations. R216W: characterized by ... and the disease caused by R216W and R216Q mutations in GATA1. The GATA1 mutation-related disease resembles the one caused by ...
"GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/blood-2016-09-687889. PMC 5391620. PMID ... Diseases of veins, lymphatic vessels and lymph nodes, Lymphatic vessel diseases). ... Venous and Lymphatic Disease". In Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, Pollock RE (eds.). ... "Lymphatic filariasis: the disease and its control. Fifth report of the WHO Expert Committee on Filariasis". World Health ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ... MonoMAC was first described by Vihn and colleagues in 2010 as an autosomal dominant familial disease. One year later, Dickinson ... Bowen disease of the vulva, and multiple Epstein-Barr virus(+) leiomyosarcoma. Patients may also develop pulmonary alveolar ... for the many diverse presentations of a genetic disorder that groups these presentations together into a single disease termed ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ... reflecting the disease's neoplastic nature. Other diseases in this category are juvenile myelomonocytic leukaemia, atypical CML ... For this reason, many disease entities in these groups show a great deal of heterogeneity. In 2001, the WHO Classification of ... The treatment of CMML remains challenging due to the lack of clinical trials investigating the disease as its own clinical ...
Khoriaty, Rami; Vasievich, Matthew P.; Ginsburg, David (2012-07-05). "The COPII pathway and hematologic disease". Blood. 120 (1 ... These results suggest that enhanced ER stress response is likely part of the molecular mechanism of the human disease. There is ... as the loss of selected copies often results in a genetic disease. The mammalian repertoire consists of two SAR1 paralogs, ... Rare diseases, Vesicular transport proteins, Congenital disorders, Neurodevelopmental disorders). ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ... By 1900, leukemia was viewed as a family of diseases as opposed to a single disease. By 1947, Boston pathologist Sidney Farber ... medications used to kill leukemia cells Cancer-related fatigue Hematologic diseases, the large class of blood-related disorders ... The disease is restricted to individuals with Down syndrome or genetic changes similar to those in Down syndrome, develops in a ...
"The COPII pathway and hematologic disease". Blood. 120 (1): 31-8. doi:10.1182/blood-2012-01-292086. PMC 3390960. PMID 22586181 ... Using positional cloning, the gene was identified as the disease gene leading to combined deficiency of factor V-factor VIII, a ... 2003). "Mannose binding lectin polymorphisms as a disease-modulating factor in women with systemic lupus erythematosus from ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ... PAP is one of the rare lung diseases currently being studied by the Rare Lung Diseases Consortium. The consortium is part of ... 2020, rarediseases.org/rare-diseases/pulmonary-alveolar-proteinosis/. Whitsett JA, Wert SE, Weaver TE (2015). "Diseases of ... Rare diseases, Congenital defects of phagocyte number, function, or both, Autoimmune diseases). ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ... Cases of the disease not associated with mediastinal germ cell tumors occur in adults who as a group have older median age ... List of hematologic conditions Hahn AW, Li B, Prouet P, Giri S, Pathak R, Martin MG (January 2016). "Acute megakaryocytic ... These children should bear one or more of the genetic aberrations associated with the disease but not the inactivating GATA1 ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ... Charcot-Marie-Tooth disease an inherited neurological disorder with delayed onset that can affect the ears as well as other ... Toxoplasmosis, a parasitic disease affecting 23% of the population in the U.S., can cause sensorineural deafness to the fetus ... It can help identify conductive hearing loss due to disease of the middle ear or eardrum from other kinds of hearing loss ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ... The trial had 8 disease-free survivors and obtained an overall survival 76 months with a range of 18 to 95 months. An NIH ... In about 70% of the cases, the inactivating GATA2 mutations found in Familial MDS/AML are associated with advanced disease and ... Congenital neutropenia refers to an assorted group of diseases that share a common set of signs and symptoms, viz., neutropenia ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ... The disease in Down syndrome occurs in ~10% of individuals who previously had TMD. During the interval between TMD and the ... The diseases also causes a reduction in the maturation of erythroblasts to circulating red blood cells and, consequently, mild ... Transient myeloproliferative disease develops and may be of concern in fetuses. Features in a review of 39 reported fetal cases ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-2110. doi:10.1182/ ... Kostmann disease, SCN3, is inherited in an autosomal recessive manner, but the commonest subtype of Kostmann syndrome, SCN1, is ... Kostmann disease is a form of severe congenital neutropenia (SCN), specifically type 3 (SCN3), which is a rare autosomal ... Diseases are excluded that overtly affect multiple systems rather than impacting myelopoiesis most prominently. Thus SCN ...
Crispino JD, Horwitz MS (April 2017). "GATA factor mutations in hematologic disease". Blood. 129 (15): 2103-10. doi:10.1182/ ... The disease is restricted to individuals with Down syndrome or genetic changes similar to those in Down syndrome, develops ... Transient myeloproliferative disease is the abnormal proliferation of a clone of noncancerous megakaryoblasts in the liver and ... Also, congenital diseases such as congenital dyserythropoietic anemia (CDA I through IV) have been recognized, Pearson's ...
... hematologic and neoplastic diseases such as leukemia or bony tumors; and other connective tissue diseases (such as systemic ... Rarely, metabolic diseases, such as Farber disease may also mimic JIA. Patients with Farber disease typically have subcutaneous ... The disease appears to be more common in girls, and is most common in Caucasians. The cause of JIA, as the word "idiopathic" ... There are disease-related factors, which relate to the inflammatory process, and anatomical or biomechanical changes that are ...
Rosai-Dorfman disease Immunoblast List of hematologic conditions Swerdlow, S.H.; Campo, E.; Harris, N.L.; Jaffe, E.S.; Pileri, ... 2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. Siegert W, Nerl C, Agthe A, ... There are several clinical trials that offer treatment options that can fight the disease. Stem cell transplantation is the ... or that the disease has a premalignant subtype. The Epstein-Barr virus (EBV) is observed in the majority of cases, being ...
Von Willebrand disease List of hematologic conditions Bouchard, Philippe (December 2011). "Current and future medical ...
... inflammatory diseases, and viral infections. Hyperactive apoptosis can lead to neurodegenerative diseases, hematologic diseases ... Allergy and autoimmune diseases such as Parkinson's and Alzheimer's disease. Genetic factors: Such as Down's syndrome and ... Ames, BN; Shigenaga, MK; Hagen, TM (September 1993). "Oxidants, antioxidants, and the degenerative diseases of aging". Proc. ... Inhibition of apoptosis can result in a number of cancers, autoimmune diseases, ...
"Antibody Response to COVID-19 Vaccination in Adults With Hematologic Malignant Disease". JAMA Oncology. 7 (11): 1714-1716. doi: ... In the typical disease course for hepatitis B, the individual will first seroconvert for hepatitis B surface antigen (HBsAg). ... Infectious Diseases. 21 (2): e26-e35. doi:10.1016/S1473-3099(20)30773-8. PMC 7837315. PMID 33125914. Long QX, Liu BZ, Deng HJ, ... Some studies have disputed the link between concentrations of antibodies of either IgM or IgG and the severity of the disease ...
Transfusion Support in Patients with Hematologic Disease: Transfusions in Special Clinical Circumstances. 57 (2): 39-50. doi: ... sickle cell disease. leukemia. aplastic anemia. myelodysplastic syndrome. Hemoglobin, the oxygen-carrying molecule in a red ... Frequent blood transfusions may be given to many patients, such as those with thalassemia, sickle cell disease, leukemia, ... Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. Vol. 13. Springer. pp. 229-294. ...
She had over 125 publications on hematologic diseases in international medical journals, as well as being coauthor of many ... She worked on many hematologic diseases, including leukemias, anemias, and Behçet's syndrome. She was also a visiting physician ...
Hereditary elliptocytosis Sickle-cell disease List of hematologic conditions Wrong, O; Bruce, LJ; Unwin, RJ; Toye, AM; Tanner, ... there is a clinically significant reduction in both disease severity and prevalence of malaria in those with SAO. Because of ...
List of cutaneous conditions Hematologic disease List of cancer types "Juvenile Myelomonocytic Leukemia". St. Jude Children's ... "Myelodysplastic/Myeloproliferative Diseases Treatment - National Cancer Institute". 2003-09-24. Tiu R. V.; Sekeres M. A. (2014 ... Niemeyer C. M. (2014). "RAS diseases in children". Haematologica. 99 (11): 1653-1662. doi:10.3324/haematol.2014.114595. PMC ... The differential diagnosis list includes infectious diseases like Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, ...
EF may also affect individuals with hematologic disease such as leukemia and lymphoma. It may also affect otherwise normal ... The name eosinophilic folliculitis refers to the predominant immune cells associated with the disease (eosinophils) and the ... Teraki, Y; Nishikawa, T (2005). "Skin diseases described in Japan 2004". Journal der Deutschen Dermatologischen Gesellschaft. 3 ... Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0. Ofuji, S; Ogino, A; Horio, T; Oseko, T; ...
Young characterized the subsequent hematologic manifestations in patients with sickle cell disease immune deficient individuals ... Viruses As Agents of Haematological Disease. London: Baillière Tindall, 1995. Calado RT, Young NS. Telomere diseases. N Engl J ... Somatic Mutations in "Benign" Disease. N Engl J Med. 2021 May 27;384(21):2039-2052[6] Danazol Treatment for Telomere Diseases. ... Telomere diseases. N Engl J Med. 2009 Dec 10;361(24):2353-65[4] Young NS. Aplastic Anemia. N Engl J Med. 2018 Oct 25;379(17): ...
"Cytochrome P450 2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth". Journal of ... of non-alcoholic fatty liver disease and certain types inflammation-related kidney diseases including chronic kidney disease, ... renal ischemia-reperfusion injury, and polycystic kidney disease. The protective role of EETs in these animal model diseases ... Furthermore, coronary artery disease patients who had lower levels of EETs/14,15-di-ETE ratios exhibited evidence of a poorer ...
Hematologic diseases are disorders which primarily affect the blood & blood-forming organs. Hematologic diseases include rare ... Rh disease (Rh D) ABO hemolytic disease of the newborn Anti-Kell hemolytic disease of the newborn Rhesus c hemolytic disease of ... also known as Christmas disease) Hemophilia C Von Willebrand disease Disseminated intravascular coagulation Protein S ... hematologic.niddk.nih.gov/info/index.htm (Articles with short description, Short description is different from Wikidata, ...
... peripheral arterial occlusive disease [PAOD]). Claudication occurs during physical activity and is relieved after a short rest. ... is one of the most common manifestations of peripheral vascular disease caused by atherosclerosis ( ... Peripheral arterial occlusive disease. Procedures performed during acute admission for peripheral arterial disease in US from ... AHA/ACC Guideline on Lower-Extremity Peripheral Arterial Disease. *SVS Guidelines on Atherosclerotic Occlusive Disease of Lower ...
Inonotosis in Patient with Hematologic Malignancy. Emerging Infectious Diseases. 2018;24(1):180-182. doi:10.3201/eid2401.171265 ... should be added to the list of microorganisms causing invasive fungal disease in neutropenic patients with hematologic ... Recognizing filamentous basidiomycetes as agents of human disease: A review. Med Mycol. 2014;52:782-97. DOIPubMedGoogle Scholar ... Invasive disease caused by Inonotus spp. (Phellinus tropicalis and P. undulatus) in humans has been described in 1 patient with ...
Title: Proteomics: Diabetes, Obesity, And Endocrine, Digestive, Kidney, Urologic, And Hematologic Diseases (R01) Announcement ... Receive a second level of review by the National Diabetes and Digestive and Kidney Diseases Advisory Council. ... Division of Diabetes, Endocrinology, and Metabolic Diseases National Institute of Diabetes and Digestive and Kidney Diseases ... endocrine and metabolic diseases, nutritional function and diseases of the alimentary tract, exocrine pancreas, liver, kidney, ...
2018 Session , Challenging Hematologic Complications Post-Stem Cell Transplantation and Beyond. *2018 Session , Advanced ... 2018 Session , Alpha Thalassemia-A Growing Public Health Disease with Changing Landscape of In-Utero and Post-Natal Therapy ... Sickle Cell Disease in the AYA population: Management Challenges for the Pediatric Hematologist ... 2019 Session , (2010) Novel Next-Generation Sequence based Assay for Non-Invasive Prenatal Testing of Sickle Cell Disease ...
Table 1.Hematologic trait variance explained by polygenic trait scores in sickle cell disease patients. ... Sickle cell disease (SCD), the most frequent monogenic disease worldwide, is caused by mutations in the β-globin gene.1 SCD ... Several of the complications observed in sickle cell disease (SCD) are influenced by variation in hematologic traits (HT), such ... Variation and impact of polygenic hematologic traits in monogenic sickle cell disease ...
... and Total-Body Irradiation in Treating Patients With Hematologic Disease. March 6, 2020. checkorphan ... Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral ... and Total-Body Irradiation in Treating Patients With Hematologic Disease Bendamustine Plus Rituximab Versus CHOP Plus Rituximab ... Rituximab in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic ...
Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or ... Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral ... and Total-Body Irradiation in Treating Patients With Hematologic Disease Bendamustine Plus Rituximab Versus CHOP Plus Rituximab ... Rituximab in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic ...
"Hematologic Diseases" by people in this website by year, and whether "Hematologic Diseases" was a major or minor topic of these ... "Hematologic Diseases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Hematologic Diseases" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Hematologic Diseases". ...
The Hematologic Diseases Information Service is a part of the NIDDKs Division of Kidney, Urologic, and Hematologic Diseases. ... The Hematologic Diseases Information Service is an information dissemination service of the National Institute of Diabetes and ... The National Institute of Diabetes and Digestive and Kidney Diseases , of the U.S. National Institutes of Health, conducts and ... Digestive and Kidney Diseases. National Institute of Diabetes and Digestive and Kidney Diseases ...
Dive into the research topics of Hematologic manifestations of celiac disease. Together they form a unique fingerprint. ...
Solitary oral lesions may be part of a multisystem disease, and oral/periodontal disease may also be an early sign of disease ... Chronic liver disease. Chronic liver disease impacts many systems of the body. The coagulation pathway is one such system. The ... Kawasaki disease has replaced rheumatic fever as the primary cause of childhood heart disease in the United States. Children ... Other granulomatous diseases must be excluded, such as Wegener granulomatosis, Crohn disease, syphilis, or tuberculosis. [28, ...
Solitary oral lesions may be part of a multisystem disease, and oral/periodontal disease may also be an early sign of disease ... Chronic liver disease. Chronic liver disease impacts many systems of the body. The coagulation pathway is one such system. The ... Kawasaki disease has replaced rheumatic fever as the primary cause of childhood heart disease in the United States. Children ... Other granulomatous diseases must be excluded, such as Wegener granulomatosis, Crohn disease, syphilis, or tuberculosis. [28, ...
Blood diseases of infancy and childhood : in the tradition of C. H. Smith / editor, Denis R. Miller ; associate editor, Robert ...
Green tea consumption was associated with a lower risk of hematologic malignancies. ... or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional ... Risk of hematologic malignancies was inversely associated with green tea consumption. The multivariate-adjusted hazard ratio of ... Green tea consumption was associated with a lower risk of hematologic malignancies. - GreenMedInfo Summary ...
Pharmacogenomics and hematologic diseases. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and ...
Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: Principles, approaches, and ... Detection of minimal residual disease (MRD) has prognostic value in many hematologic malignancies, including acute ... Detection of minimal residual disease (MRD) has prognostic value in many hematologic malignancies, including acute ... Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: Principles, approaches, and ...
Regional Centre of Expertise for rare hematologic diseases. Azienda Ospedaliera Ospedali Riuniti "Villa Sofia-Cervello" - ... Centre of Expertise for pediatric hematologic and oncohematologic diseases. IRCCS Azienda Ospedaliero Universitaria di Bologna ... Centre for Rare Haematologic Diseases (Associated National Centre in the EuroBloodNet). Competence Centre for Rare Diseases - ... Multidisciplinary expert team / Competence Centre for Rare Diseases. Competence Centre for Rare Diseases - Tartu University ...
Hematologic Diseases / diagnosis* * Humans * Kidney Diseases / diagnosis* * Male * Middle Aged * Nails, Malformed* ...
... digestive diseases, nutrition and obesity; and kidney, urologic and hematologic diseases. Spanning the full spectrum of ... According to the Centers for Disease Control and Prevention, more than one-third of U.S. adults are obese. Obesity-related ... The NIDDK, a component of the NIH, conducts and supports research on diabetes and other endocrine and metabolic diseases; ... and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov. ...
A wide variety of diseases are associated with splenomegaly, or enlargement of the spleen, with many of the mechanisms leading ... Splenectomy for hematologic disease. The UCLA experience with 306 patients. Ann Surg. 1984 Jul. 200(1):40-5. [QxMD MEDLINE Link ... Splenectomy for hematologic disease. Surg Gynecol Obstet. 1979 Oct. 149(4):509-12. [QxMD MEDLINE Link]. ... Laparoscopic splenectomy in patients with hematologic diseases. Ann Surg. 1996 Jul. 224(1):19-28. [QxMD MEDLINE Link]. [Full ...
Includes hematologic malignant disease.. Often, however, patients or families will not ask directly about the prognosis, and ... Tell me how the past year has been going... Has anyone spoken to you in the past about what to expect from your disease and the ... Child class C liver disease, Child class B liver disease with gastrointestinal bleeding ... Chronic obstructive pulmonary disease (2 of the following: baseline arterial partial pressure of carbon dioxide , 45 mm Hg, cor ...
PART Body Systems and Diseases - Understanding Pathophysiology - 24 Alterations of Hematologic Function in Children for Nursing ... 24 - Alterations of Hematologic Function in Children. 9. Picmonics to Learn , 20 mins ...
Unusual pulmonary mycoses in patients with hematologic disease [French]. Rev Pneumol Clin 1998;54:253--7. ... Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). ... Nosocomial outbreak of Legionnaires disease: molecular epidemiology and disease control measures. Infect Control 1987;8:53--8 ... epidemiologic link with disease and evaluation of a method for control of nosocomial Legionnaires disease and Pittsburgh ...
... digestive diseases, nutrition, and obesity; and kidney, urologic, and hematologic diseases. For more information, visit www. ... from hearing loss to heart disease to nonalcoholic fatty liver disease. With this third edition of Diabetes in America, we ... The book reports on well-known complications of diabetes, such as heart, eye, kidney and nerve diseases, and also shows the ... Now, researchers at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National ...
Use of octreotide in the symptomatic management of diarrhea induced by graft-versus-host disease in patients with hematologic ... Use of octreotide in the symptomatic management of diarrhea induced by graft-versus-host disease in patients with hematologic ... Use of octreotide in the symptomatic management of diarrhea induced by graft-versus-host disease in patients with hematologic ... Use of octreotide in the symptomatic management of diarrhea induced by graft-versus-host disease in patients with hematologic ...
... were studied in adults with sickle cell disease (SCD) who were stably on HU. Methods: Twenty four courses of l-arginine (0.1- ... Hematologic responses are reported in 14 subjects with HbSS who had stable baseline HbF levels. Results: l-arginine increased ... Hematologic responses are reported in 14 subjects with HbSS who had stable baseline HbF levels. Results: l-arginine increased ... Hematologic responses are reported in 14 subjects with HbSS who had stable baseline HbF levels. Results: l-arginine increased ...
To submit an abstract research and/or studies must fit into one of the ASH Summit on Immunotherapies for Hematologic Diseases ... Note: Abstracts submitted to the ASH Summit on Immunotherapies for Hematologic Diseases are eligible to be re-submitted to the ... Note: Abstracts submitted to the ASH Summit on Immunotherapies for Hematologic Diseases are eligible to be re-submitted to the ... Please consider the following before submitting your abstract to the ASH Summit on Immunotherapies for Hematologic Diseases:. * ...
... to highlight Janssens research in other hematologic diseases ... to highlight Janssens research in other hematologic diseases. ... Janssen also continues to evolve the treatment approaches for rare hematologic diseases including newly diagnosed light chain ( ... and today is indicated for adult patients in six disease areas, including five hematologic cancers. These include adults with ... Reducing the risk of serious heart problems, heart attack and stroke in coronary artery disease: ...
  • should be added to the list of microorganisms causing invasive fungal disease in neutropenic patients with hematologic malignancies. (cdc.gov)
  • Green tea consumption was associated with a lower risk of hematologic malignancies. (greenmedinfo.com)
  • Green tea consumption and hematologic malignancies in Japan: the Ohsaki study. (greenmedinfo.com)
  • Several biologic studies have reported that green tea constituents have antitumor effects on hematologic malignancies. (greenmedinfo.com)
  • The authors used data from the Ohsaki National Health Insurance Cohort Study in Japan to evaluate the association between green tea consumption and the risk of hematologic malignancies. (greenmedinfo.com)
  • During 9 years of follow-up beginning in 1995, the authors documented 157 hematologic malignancies, including 119 cases of lymphoid neoplasms and 36 cases of myeloid neoplasms. (greenmedinfo.com)
  • Risk of hematologic malignancies was inversely associated with green tea consumption. (greenmedinfo.com)
  • The multivariate-adjusted hazard ratio of hematologic malignancies for 5 cups/day or more compared with less than 1 cup/day of green tea was 0.58 (95% confidence interval: 0.37, 0.89). (greenmedinfo.com)
  • Detection of minimal residual disease (MRD) has prognostic value in many hematologic malignancies, including acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia, non-Hodgkin's lymphoma, and multiple myeloma. (unimib.it)
  • We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH 2021," said Peter Lebowitz, M.D., Ph.D., Global Therapeutic Area Head, Oncology, Janssen Research & Development, LLC. (jnj.com)
  • 6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
  • Hematologic diseases are disorders which primarily affect the blood & blood-forming organs. (wikipedia.org)
  • Hematologic diseases include rare genetic disorders, anemia, HIV, sickle cell disease & complications from chemotherapy or transfusions. (wikipedia.org)
  • Perioperative Approach to Anticoagulants and Hematologic Disorders. (rush.edu)
  • Low-dose radiotherapy has been used as palliative care for splenomegaly in patients with hematologic disorders such as primary myelofibrosis. (medscape.com)
  • Laparoscopic splenectomy is becoming the standard procedure for benign splenic disorders including hematologic diseases and hypersplenism. (sages.org)
  • and kidney, urologic and hematologic diseases. (nih.gov)
  • The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is seeking an exceptional candidate to serve as a Program Officer of Research Training and Career Development in the extramural Division of Kidney, Urologic and Hematologic Diseases (DKUHD. (sdbonline.org)
  • The Program Officer will serve as a program expert for the research education and training of individuals in the areas of Kidney, Urologic and Hematologic Diseases research. (sdbonline.org)
  • The ideal candidate will possess general knowledge of basic, clinical and translational research from any scientific background, including disciplines broadly related to kidney, urologic and hematologic diseases. (sdbonline.org)
  • The book features new sections on Hematotoxicity and Quality Control and Laboratory Techniques, and includes expanded sections on Laboratory Animal Hematology, Species Specific Hematology, and Hematologic Neoplasia. (chipsbooks.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • According to the Centers for Disease Control and Prevention, more than one-third of U.S. adults are obese. (nih.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Several of the complications observed in sickle cell disease (SCD) are influenced by variation in hematologic traits (HT), such as fetal hemoglobin (HbF) level and neutrophil count. (haematologica.org)
  • Sickle cell disease (SCD), the most frequent monogenic disease worldwide, is caused by mutations in the β-globin gene. (haematologica.org)
  • However, there is a lack of evidence from trials showing that splenectomy improves survival and decreases morbidity in sickle cell disease. (medscape.com)
  • l-arginine, an NO precursor, and the phosphodiesterase (PDE) 5 inhibitor sildenafil, which potentiates cGMP, were studied in adults with sickle cell disease (SCD) who were stably on HU. (johnshopkins.edu)
  • Obesity-related conditions include heart disease, type 2 diabetes and certain types of cancer, some of the leading causes of preventable death. (nih.gov)
  • Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined to represent a paraneoplastic syndrome. (medscape.com)
  • The development of bosutinib is evidence of our commitment to bringing meaningful new medicines to patients with hematologic cancers,' said Mace Rothenberg, MD, senior vice president of Clinical Development and Medical Affairs, Pfizer Oncology Business Unit. (aol.com)
  • Specifically, we will use proteomic analysis, flow cytometry and genomic sequencing to detect early signs of myeloma, chronic lymphocytic leukemia and myelodysplastic syndromes in these cases, to enable potentially disease altering therapeutic interventions for these cancers. (cdc.gov)
  • Notre etude avait pour objectif de faire le bilan de la prise en charge des cancers hematologiques dans les services d'hematologie oncologie medicale et de medecine interne de l'hopital du Point G de 1996 a 2003. (bvsalud.org)
  • [ 26 ] Bruns et al reported that low-dose splenic irradiation produced hematologic response and long-term relief of splenic pain in four of five patients with symptomatic congestive splenomegaly. (medscape.com)
  • Apart from IDA, other hematologic abnormalities seen in patients with CD are thrombocytosis, splenic hypofunction, leukopenia, IgA deficiency, enteropathy-associated T cell lymphoma (EATL), and rarely venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE). (hindawi.com)
  • A full list of company-sponsored abstracts, which include data in multiple myeloma, lymphoma, leukemia, von Willebrand disease and hemophilia can be found here ( https://www.takedaoncology.com/siteassets/media/takeda-ash-abstract_12-6-22.pdf ). (koreanewswire.co.kr)
  • Simvastatin reduces cardiovascular heart disease mortality and morbidity (eg, nonfatal MI or stroke and revascularization procedures) in high-risk patients (ie, those with existing coronary heart disease, diabetes, peripheral vessel disease, or a history of stroke or other cerebrovascular disease). (medscape.com)
  • Oral manifestations can prove crucial in diagnosis and usually parallel the intestinal disease course. (medscape.com)
  • [ 8 ] However, oral manifestations at follow-up once disease is controlled may not be a marker for recurring intestinal disease. (medscape.com)
  • Whether patients with orofacial granulomatoses will subsequently develop intestinal manifestations of Crohn disease is uncertain, but histologic similarities between the oral lesions and the intestinal lesions are obvious. (medscape.com)
  • Manifestations of the disease are provoked in large part by the resultant increase in mast cell-derived mediators, which have a variety of local and systemic effects. (nih.gov)
  • Mastocytosis is variable in respect to the organ systems involved, clinical manifestations, and association with hematologic diseases. (nih.gov)
  • NIH, NIAID, and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) recognize a unique and compelling need to promote diversity in the biomedical, behavioral, clinical, and social sciences workforce. (nih.gov)
  • Chronic kidney diseases in agricultur al communities: report from a workshop. (cdc.gov)
  • In June 2018, the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Environmental Health Sciences sponsored a workshop to identify research gaps in an increasingly common form of chronic kidney disease in agricultur al communities, often termed "CKDu. (cdc.gov)
  • In response to the ongoing COVID-19 pandemic and the emerging evidence about the Omicron variant, ASH has decided to postpone the March 2022 Summit on Immunotherapies for Hematologic Diseases to early 2023. (confex.com)
  • Abstracts submitted to the ASH Summit on Immunotherapies for Hematologic Diseases are eligible to be re-submitted to the 2022 ASH Annual Meeting. (confex.com)
  • It's a resource for everyone, because diabetes affects just about everyone, from the more than 110 million Americans with or at risk for the disease to the many more people who care for them. (nih.gov)
  • The book reports on well-known complications of diabetes, such as heart, eye, kidney and nerve diseases, and also shows the connection between diabetes and other serious conditions, including cancer, dementia, bone fractures, and urinary incontinence. (nih.gov)
  • Diabetes doubles the risk of many devastating conditions in the body, from hearing loss to heart disease to nonalcoholic fatty liver disease. (nih.gov)
  • The NIDDK-funded Diabetes Prevention Program (DPP) found that people who are at high risk for type 2 diabetes can prevent or delay the disease by losing a modest amount of weight. (nih.gov)
  • Through years of research and community engagement, Janssen continues to build upon its knowledge of multiple myeloma and the challenges faced by patients at all stages of this complex disease. (jnj.com)
  • We believe Merck is well-positioned to apply its industry-leading clinical and commercial capabilities to harness the potential of sotatercept as we join together to help make an impact on cardiopulmonary disease for the benefit of patients. (pharmiweb.com)
  • 5 However, most SCD patients have lower HbF levels while not receiving disease-modifying therapy, and for some complications, such as stroke, the risk reduction associated with HbF has not been quantified in large cohorts. (haematologica.org)
  • During the course of initial treatment some patients may never respond, may develop drug-resistant disease or may not be able to tolerate their therapy. (aol.com)
  • The heterogeneity of the disease patterns in mastocytosis strongly suggests that more than one biologic lesion may occur in the developmental sequence that leads to placement of mature mast cells in tissues. (nih.gov)
  • Filamentous Basidiomycetes molds are ubiquitous and able to colonize in patients with chronic pulmonary disease. (cdc.gov)
  • Intraoral involvement in Crohn disease occurs in 8-29% of patients and may precede intestinal involvement. (medscape.com)
  • The health-care facility environment is rarely implicated in disease transmission, except among patients who are immunocompromised. (cdc.gov)
  • Takeda's latest research focuses on improving long-term outcomes for patients with hematologic diseases. (koreanewswire.co.kr)
  • Our latest research is focused on investigating novel mechanisms of action, as well as optimizing approved treatments to improve long-term outcomes and more deeply understand and address unmet needs for patients across a range of hematologic diseases," said Awny Farajallah, M.D., Head of Global Medical Affairs Oncology at Takeda. (koreanewswire.co.kr)
  • Not all patients with celiac disease have these classic symptoms. (hindawi.com)
  • Hematologic abnormalities are frequently found in CD patients, with iron deficiency anemia (IDA) being the most common. (hindawi.com)
  • The positive opinion for bosutinib was based on data from Study 200, a global, single-arm, open-label, multi-cohort, Phase 1/2 study of bosutinib in more than 500 patients with Ph+ CML with separate cohorts for chronic, accelerated and blast phase disease previously treated with one or more prior TKIs. (aol.com)
  • Hematologic Diseases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • Celiac disease (CD) is a systemic, chronic autoimmune disease that occurs in genetically predisposed individuals following dietary gluten exposure. (hindawi.com)
  • Venous thromboembolism (VTE) as a presentation of celiac disease is unusual and rarely reported. (hindawi.com)
  • It is important to recognize that the first symptoms or signs of celiac disease might be extraintestinal. (hindawi.com)
  • Celiac disease (CD), or gluten sensitive enteropathy, is a common, systemic autoimmune disease that occurs in genetically predisposed individuals secondary to exposure to dietary protein gluten and requires lifelong dietary treatment [ 1 ]. (hindawi.com)
  • The prevalence of celiac disease worldwide is about 1% with wide geographical variations. (hindawi.com)
  • these forms are termed atypical and silent celiac disease, respectively [ 4 ]. (hindawi.com)
  • PE has rarely been reported as a presentation of celiac disease [ 7 , 8 ]. (hindawi.com)
  • Here we report a case of pulmonary embolism that was the presenting feature of celiac disease and review of the literature. (hindawi.com)
  • Hematologic traits (HT) are among the main factors known to be associated with clinical outcomes in SCD. (haematologica.org)
  • NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. (nih.gov)
  • Actinium is advancing the only multi-disease, multi-target, clinical-stage pipeline for targeted conditioning to enable cellular therapies such as BMT or Bone Marrow Transplant (BMT) and CAR-T. The target market for Actinium's ARC or Antibody Radiation Conjugate drug candidates is concentrated within the top 75-100 hospitals in the U.S. that perform a majority of BMT and CAR-T procedures. (prnewswire.com)
  • Eosinophils become active when you have certain allergic diseases, infections, and other medical conditions. (medlineplus.gov)
  • We are pleased to have Dr. David Shay, who is a medical officer in the National Center for Immunization and Respiratory Diseases. (cdc.gov)
  • We report a lung-invasive fungal disease with possible cutaneous needle tract seeding in a patient with a febrile neutropenia caused by the Basidiomycetes mold Inonotus spp. (cdc.gov)
  • Crohn disease is an idiopathic disorder that can involve the entire GI tract with transmural inflammation, noncaseating granulomas, and fissures. (medscape.com)
  • This disease is caused by a change in the genetic material (DNA). (nih.gov)
  • Hematologic responses are reported in 14 subjects with HbSS who had stable baseline HbF levels. (johnshopkins.edu)
  • The cutaneous porphyrias are dermatologic diseases that may or may not involve the liver and nervous system. (medscape.com)
  • Acceleron's innovative research has yielded an exciting late-stage candidate that complements and strengthens our growing cardiovascular portfolio and pipeline and holds the potential to build upon Merck's proud legacy in cardiovascular disease. (pharmiweb.com)
  • Symptoms of Crohn disease include intermittent attacks of diarrhea, constipation, abdominal pain, and fever. (medscape.com)
  • Symptoms of this disease may start to appear as a Newborn and as an Infant. (nih.gov)
  • The age symptoms may begin to appear differs between diseases. (nih.gov)
  • The symptoms from some diseases may begin at any age. (nih.gov)
  • The types of symptoms experienced, and their intensity, may vary among people with this disease. (nih.gov)
  • Some may have no symptoms, mild symptoms or severe disease. (who.int)
  • People with mild symptoms of both diseases can usually be treated safely at home. (who.int)
  • o Signs or symptoms consistent with active TB disease. (cdc.gov)
  • 1 Mast Cell Physiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. (nih.gov)
  • Both regimens are given every 28 d, along with infectious disease (ID) prophylaxis. (medscape.com)
  • Flor Munoz disclose she receives a royalty for offering the Seasonal Influenza in Children chapter in UpToDate and is a member of the Data Safety Monitoring Board Pfizer, Moderna, and is a member of American pediatrics committee on infectious diseases. (cdc.gov)
  • Who is an Associate Professor of Pediatrics, Infectious Diseases, and Molecular Virology and Microbiology at Baylor College of Medicine. (cdc.gov)
  • 5 to 3, when the delta variant up to 5 and further context provided that most infectious typical viral disease of childhood is Measles which has an R naught of 12 to 18. (cdc.gov)
  • Fissures or fistulas may occur in persons with chronic disease. (medscape.com)
  • Antiplatelet agents decrease the overall risk of cardiovascular disease from myocardial infarction (MI) and stroke. (medscape.com)
  • To submit an abstract research and/or studies must fit into one of the ASH Summit on Immunotherapies for Hematologic Diseases Abstract Review Categories . (confex.com)
  • All hypotheses regarding etiology were entertained, and meeting participants discussed potential research strategies, choices in study design, and novel tools that may prove useful in this disease. (cdc.gov)
  • 57 disease terms (MeSH) has been reported with SCNN1A gene. (cdc.gov)
  • [ 9 ] Extraintestinal features are also common in persons with Crohn disease, and these may manifest systemically as arthritis, clubbing of the fingers, sacroiliitis, and erythema nodosum. (medscape.com)
  • CheckOrphan is a non-profit organization located in Basel, Switzerland and Santa Cruz, California that is dedicated to rare, orphan and neglected diseases. (checkorphan.org)
  • Questions about rare diseases? (nih.gov)
  • RareSource offers rare disease gene variant annotations and links to rare disease gene literature. (nih.gov)
  • Many rare diseases have limited information. (nih.gov)
  • Spanning the full spectrum of medicine and afflicting people of all ages and ethnic groups, these diseases encompass some of the most common, severe and disabling conditions affecting Americans. (nih.gov)
  • Purpose: Diarrhea associated with acute gastrointestinal (GI) graft- versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) can result in severe morbidity and mortality. (elsevierpure.com)
  • AOEs included fatal myocardial infarction, stroke, stenosis of large arterial vessels of the brain, severe peripheral vascular disease, and the need for urgent revascularization procedures. (koreanewswire.co.kr)
  • Vaccination is an important part of preventing severe disease and death for both COVID-19 and influenza. (who.int)
  • COVID-19 vaccines have been proven to protect against severe illness and death caused by COVID-19 disease. (who.int)

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