A species of HELICOBACTER that colonizes in the STOMACH of laboratory MICE; CATS; and DOGS. It is associated with lymphoid follicular hyperplasia and mild GASTRITIS in CATS.
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
A genus of gram-negative, spiral-shaped bacteria that has been isolated from the intestinal tract of mammals, including humans. It has been associated with PEPTIC ULCER.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 3.5.1.5.
A species of gram-negative, spiral-shaped bacteria found in the gastric mucosa that is associated with chronic antral gastritis. This bacterium was first discovered in samples removed at endoscopy from patients investigated for HELICOBACTER PYLORI colonization.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
Tumors or cancer of the STOMACH.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A species of HELICOBACTER that colonizes the CECUM and COLON of several strains of MICE, and is associated with HEPATITIS and carcinogenesis.
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
Impaired digestion, especially after eating.
Proteins found in any species of bacterium.
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
Substances elaborated by bacteria that have antigenic activity.
Pathological processes involving the STOMACH.
GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.
A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.
The region between the sharp indentation at the lower third of the STOMACH (incisura angularis) and the junction of the PYLORUS with the DUODENUM. Pyloric antral glands contain mucus-secreting cells and gastrin-secreting endocrine cells (G CELLS).
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Any tests done on exhaled air.
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.
Substances that reduce the growth or reproduction of BACTERIA.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Endoscopic examination, therapy or surgery of the interior of the stomach.
A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.
Therapy with two or more separate preparations given for a combined effect.
A condition in which there is a change of one adult cell type to another similar adult cell type.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.
A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.
This is one of 2 related pepsinogen systems in humans and is also known as pepsinogen. (The other is PEPSINOGEN C.) This includes isozymogens Pg1-Pg5 (pepsinogens 1-5, group I or products of PGA1-PGA5 genes). This is the main pepsinogen found in urine.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.
Techniques used in microbiology.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A PEPTIC ULCER located in the DUODENUM.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
A genus of bacteria found in the reproductive organs, intestinal tract, and oral cavity of animals and man. Some species are pathogenic.

The significance of cagA and vacA subtypes of Helicobacter pylori in the pathogenesis of inflammation and peptic ulceration. (1/5095)

AIMS: To assess the significance of cagA and vacA subtypes of Helicobacter pylori in relation to inflammation and density of bacterial colonisation in vivo within a dyspeptic UK population. METHODS: Dyspeptic patients who were Helicobacter pylori positive had antral samples taken for histology and culture. Gastroduodenal pathology was noted. The grade of bacterial density and inflammation was assessed using the Sydney system. Bacterial DNA was extracted and the vacA alleles and the cagA/gene typed using PCR. RESULTS: 120 patients were studied. There was high rate of cagA positive strains in this population. Bacterial density did not correlate with the presence of peptic ulceration. There was a significant association between cagA positive strains and increased inflammation and bacterial density. The vacA s1 type independently correlated with extensive chronic inflammation but there was no association with bacterial density. The vacA m type did not correlate with extent of inflammation or bacterial density. CONCLUSIONS: The results suggest that cagA is important in the pathogenesis of inflammation and peptic ulceration. These findings are in keeping with the hypothesis that cagA acts as a marker for a cag pathogenicity island which encodes several genes involved in inflammation. The vacA s1 allele correlates with inflammation independently of cagA, possibly through its enhanced ability to produce the vacuolating cytotoxin.  (+info)

Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. (2/5095)

AIM: To investigate the association between the quantity of gastric chemokine mRNA expression, severity of gastritis, and cagA positivity in Helicobacter pylori associated gastritis. METHODS: In 83 dyspeptic patients, antral and corpus biopsies were taken for semiquantitative reverse transcription polymerase chain reaction (RT-PCR) and histological grading of gastritis. Gastritis was evaluated by visual analogue scales. Quantities of chemokine (IL-8, GRO alpha, ENA-78, RANTES, MCP-1) RT-PCR products were compared with G3PDH products. Each sample was also evaluated for the presence of cagA and ureA mRNA by RT-PCR. RESULTS: mRNA expression of all five chemokines was significantly greater in H pylori positive than in H pylori negative mucosa. In H pylori positive patients, in the antrum C-X-C chemokine mRNA expression was significantly greater in cagA positive patients than in cagA negative patients, but there were no significant differences in C-C chemokine mRNA expression. In H pylori positive patients, chemokine mRNA expression in the corpus was less than in the antrum. In contrast to the antrum, only GRO alpha mRNA expression was significantly greater in cagA positive infection. Polymorphonuclear cell infiltration was correlated with C-X-C chemokine mRNA expression. Significant correlations were also found between bacterial density and C-X-C chemokine mRNA expression. CONCLUSIONS: In H pylori infection, C-X-C chemokines may play a primary role in active gastritis. Infection with cagA positive H pylori induces greater gastric chemokine mRNA expression in the antral mucosa, which may be relevant to the increased mucosal damage associated with cagA positive H pylori infection.  (+info)

Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer. (3/5095)

BACKGROUND: Cangshan County of Shandong Province has one of the lowest rates of gastric cancer (GC) in China. While intestinal metaplasia (IM) and dysplasia (DYS) are less common in Cangshan than in areas of Shandong at high risk of GC, these precursor lesions nevertheless affect about 20% of adults age > or = 55. SUBJECTS AND SETTING: In order to evaluate determinants of IM and DYS in Cangshan County, a low risk area of GC a survey was conducted among 214 adults who participated in a gastroscopic screening survey in Cangshan County in 1994. METHOD: A dietary interview and measurement of serum Helicobacter pylori antibodies were performed. RESULTS: The prevalence of H. pylori was lowest (19%) among those with normal gastric mucosa, rising steadily to 35% for superficial gastritis (SG), 56% for chronic atrophic gastritis (CAG), 80% for IM, and 100% for DYS. The prevalence odds of precancerous lesions were compared with the odds of normal histology or SG. The odds ratio (OR) or CAG associated with H. pylori positivity was 4.2 (95% confidence interval [CI] : 1.7-10.0), while the OR of IM/DYS associated with H. pylori positivity was 31.5 (95% CI: 5.2-187). After adjusting for H. pylori infection, drinking alcohol was a risk factor for CAG (OR = 3.2, 95% CI: 1.1-9.2) and IM/DYS (OR = 7.8, 95% CI: 1.3-47.7). On the other hand, consumption of garlic showed non-significant protective effects and an inverse association with H. pylori infection. CONCLUSIONS: The findings of this study suggest that infection with H. pylori is a risk factor and garlic may be protective, in the development and progression of advanced precancerous gastric lesions in an area of China at relatively low risk of GC.  (+info)

Chronic infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus: population based study of coronary heart disease. (4/5095)

OBJECTIVE: To study possible associations between coronary heart disease and serological evidence of persistent infection with Helicobacter pylori, Chlamydia pneumoniae, or cytomegalovirus. DESIGN: Population based, case-control study, nested within a randomised trial. SETTING: Five general practices in Bedfordshire, UK. INDIVIDUALS: 288 patients with incident or prevalent coronary heart disease and 704 age and sex matched controls. RESULTS: High concentrations of serum IgG antibodies to H pylori were present in 54% of cases v 46% of controls, with corresponding results for C pneumoniae seropositivity (33% v 33%), and cytomegalovirus seropositivity (40% v 31%). After adjustments for age, sex, smoking, indicators of socioeconomic status, and standard risk factors, the odds ratios (95% confidence intervals) for coronary heart disease of seropositivity to these agents were: 1.28 (0.93 to 1.75) for H pylori, 0.95 (0.66 to 1.36) for C pneumoniae, and 1.40 (0.96 to 2. 05) for cytomegalovirus. CONCLUSIONS: There is no good evidence of strong associations between coronary heart disease and serological markers of persistent infection with H pylori, C pneumoniae, or cytomegalovirus. To determine the existence of moderate associations between these agents and disease, however, larger scale studies will be needed that can keep residual confounders to a minimum.  (+info)

Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation. (5/5095)

The Helicobacter pylori VacA toxin plays a major role in the gastric pathologies associated with this bacterium. When added to cultured cells, VacA induces vacuolation, an effect potentiated by preexposure of the toxin to low pH. Its mechanism of action is unknown. We report here that VacA forms anion-selective, voltage-dependent pores in artificial membranes. Channel formation was greatly potentiated by acidic conditions or by pretreatment of VacA at low pH. No requirement for particular lipid(s) was identified. Selectivity studies showed that anion selectivity was maintained over the pH range 4.8-12, with the following permeability sequence: Cl- approximately HCO3- > pyruvate > gluconate > K+ approximately Li+ approximately Ba2+ > NH4+. Membrane permeabilization was due to the incorporation of channels with a voltage-dependent conductance in the 10-30 pS range (2 M KCl), displaying a voltage-independent high open probability. Deletion of the NH2 terminus domain (p37) or chemical modification of VacA by diethylpyrocarbonate inhibited both channel activity and vacuolation of HeLa cells without affecting toxin internalization by the cells. Collectively, these observations strongly suggest that VacA channel formation is needed to induce cellular vacuolation, possibly by inducing an osmotic imbalance of intracellular acidic compartments.  (+info)

Influences of Helicobacter pylori on serum pepsinogen concentrations in dialysis patients. (6/5095)

BACKGROUND: Patients with impaired renal function have been known to have elevated concentrations of serum pepsinogens, which are raised by Helicobacter pylori infection of the stomach. The present study was performed to examine the effect of H. pylori infection on serum pepsinogen concentrations in dialysis patients. METHODS: Forty nine patients on dialysis and 48 subjects with no known kidney disease were examined for upper gastroduodenal endoscopy, H. pylori infection and serum concentrations of pepsinogen I and II. The status of H. pylori infection was evaluated from results of a urease test, histology and culture of biopsy specimens of the gastric mucosa. Serum pepsinogen levels were measured by radioimmunoassay. RESULTS: Serum concentrations of pepsinogen I and II were elevated in the dialysis patients in comparison with those in the controls (277.4+/-24.2 vs 52.6+/-4.0 pg/ml, P<0.01 for pepsinogen I, and 30.2+/-2.9 vs 14.9+/-1.3 pg/ml, P<0.01 for pepsinogen II). In both the dialysis patients and controls, those with H. pylori infection had significantly higher concentrations of serum pepsinogen I and II and a lower ratio of pepsinogen I to pepsinogen II than those without infection. Among the controls, 15 of 25 subjects with atrophic gastritis had a pepsinogen I/pepsinogen II ratio < or = 3.0, while only two out of 17 patients on dialysis fell into this range. CONCLUSIONS: We conclude that H. pylori status should be taken into account when serum pepsinogen concentrations are evaluated in dialysis patients.  (+info)

Natural history of Helicobacter pylori infection in childhood: 12-year follow-up cohort study in a biracial community. (7/5095)

We assessed the pattern of acquisition and loss of Helicobacter pylori infection in a cohort of 212 children from a biracial community with a homogeneous socioeconomic class. The children were followed over 12 years (1973-1974 to 1985-1986) from childhood to young adulthood. H. pylori status was assessed by the presence of serum IgG antibodies to H. pylori. At ages 7-9, 19% of children had H. pylori infection (40% of blacks vs. 11% of whites; P = .0001); 12 years later, 33% were seropositive. The higher prevalence among blacks remained (P = .0001). During follow-up, 22% of children became infected; the rate of acquisition was fourfold greater among blacks than among whites (P = .001). Over the 12-year period, infection was lost in 50% of whites compared with 4% of blacks who either remained infected or became reinfected. H. pylori infection in childhood is affected by both acquisition and loss of infection in different ethnic groups. This observation is critical for understanding the epidemiology and transmission of H. pylori infection.  (+info)

KRAS mutations predict progression of preneoplastic gastric lesions. (8/5095)

Eight hundred sixty-three subjects with atrophic gastritis were recruited to participate in an ongoing chemoprevention trial in Narino, Colombia. The participants were randomly assigned to intervention therapies, which included treatment to eradicate Helicobacter pylori infection followed by daily dietary supplementation with antioxidant micronutrients in a 2 x 2 x 2 factorial design. A series of biopsies of gastric mucosa were obtained according to a specified protocol from designated locations in the stomach for each participant at baseline (before intervention therapy) and at year three. A systematic sample of 160 participants was selected from each of the eight treatment combinations. DNA was isolated from each of these biopsies (n = 320), and the first exon of KRAS was amplified using PCR. Mutations in the KRAS gene were detected using denaturing gradient gel electrophoresis and confirmed by sequence analysis. Of all baseline biopsies, 14.4% (23 of 160) contained KRAS mutations. Among those participants with atrophic gastritis without metaplasia, 19.4% (6 of 25) contained KRAS mutations, indicating that mutation of this important gene is likely an early event in the etiology of gastric carcinoma. An important association was found between the presence of KRAS mutations in baseline biopsies and the progression of preneoplastic lesions. Only 14.6% (20 of 137) of participants without baseline KRAS mutations progressed from atrophic gastritis to intestinal metaplasia or from small intestinal metaplasia to colonic metaplasia; however, 39.1% (9 of 23) with baseline KRAS mutations progressed to a more advanced lesion after 3 years [univariate odds ratio (OR), 3.76 (P = 0.05); multivariate OR adjusted for treatment, 3.74 (P = 0.04)]. In addition, the specificity of the KRAS mutation predicted progression. For those participants with G-->T transversions at position 1 of codon 12 (GGT-->TGT), 19.4% (5 of 17) progressed (univariate OR, 2.4); however, 60.0% (3 of 5) of participants with G-->A transitions at position 1 of codon 12 (GGT-->AGT) progressed (univariate OR, 8.7; P = 0.004 using chi2 test).  (+info)

The team also evaluated histological diagnosis of biopsied gastric specimens.. There were 142 H pylori-negative and 527-positive patients.. The team measured odds ratios for H pylori-positive patients with colorectal adenoma and adenocarcinoma.. In addition, tumor patients with either adenoma or adenocarcinoma were calculated.. Among the H pylori-negative patients, there were 52 patients without tumor, 63 with adenoma, 27 with adenocarcinoma, and 90 with tumor.. The team found that among the H pylori-positive patients, there were 136, 264, 127, and 391 patients respectively.. Pooling all subjects, the researchers noted that those infected with H pylori had a significantly increased odds ratio for adenoma.. Those infected with H pylori had a significantly increased odds ratio for adenocarcinoma, or tumor, compared to H pylori-free patients.. The researchers observed that for female H pylori-positive subjects, the risk of having adenocarcinoma or tumor was significantly higher.. The research team ...
Learn about the veterinary topic of |i|Helicobacter|/i| Infection in Small Animals. Find specific details on this topic and related topics from the Merck Vet Manual.
Debate rages over whether or not this condition should be treated or not. Find out what we know and dont know about Helicobacter.
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1. Key Insights. 2. Executive Summary of Helicobacter Pylori Infections. 3. Competitive Intelligence Analysis for Helicobacter Pylori Infections. 4. Helicobacter Pylori Infections: Market Overview at a Glance. 4.1. Helicobacter Pylori Infections Total Market Share (%) Distribution in 2017. 4.2. Helicobacter Pylori Infections Total Market Share (%) Distribution in 2030. 5. Helicobacter Pylori Infections: Disease Background and Overview. 5.1. Introduction. 5.2. Sign and Symptoms. 5.3. Pathophysiology. 5.4. Risk Factors. 5.5. Diagnosis. 6. Patient Journey. 7. Helicobacter Pylori Infections Epidemiology and Patient Population. 7.1. Epidemiology Key Findings. 7.2. Assumptions and Rationale: 7MM. 7.3. Epidemiology Scenario: 7MM. 7.3.1. Helicobacter Pylori Infections Epidemiology Scenario in the 7MM (2017-2030). 7.4. United States Epidemiology. 7.4.1. Helicobacter Pylori Infections Epidemiology Scenario in the United States (2017-2030). 7.5. EU-5 Country-wise Epidemiology. 7.5.1. Germany ...
Table of Contents. Table of Contents 2. List of Tables 5. List of Figures 5. Introduction 6. Global Markets Direct Report Coverage 6. Helicobacter Pylori Infections Overview 7. Therapeutics Development 8. Pipeline Products for Helicobacter Pylori Infections-Overview 8. Pipeline Products for Helicobacter Pylori Infections-Comparative Analysis 9. Helicobacter Pylori Infections-Therapeutics under Development by Companies 10. Helicobacter Pylori Infections-Therapeutics under Investigation by Universities/Institutes 11. Helicobacter Pylori Infections-Pipeline Products Glance 12. Late Stage Products 12. Clinical Stage Products 13. Early Stage Products 14. Helicobacter Pylori Infections-Products under Development by Companies 15. Helicobacter Pylori Infections-Products under Investigation by Universities/Institutes 16. Helicobacter Pylori Infections-Companies Involved in Therapeutics Development 17. Daewoong Pharmaceutical Co., Ltd. 17. EpiVax, Inc. 18. ImevaX GmbH 19. ImmunoBiology Ltd. 20. RedHill ...
Effect of Helicobacter pylori infection on pregnancy rates and early pregnancy loss after intracytoplasmic sperm injection Masomeh Hajishafiha1, Mohammad Ghasemi-rad1, Aishe Memari1, Siamak Naji1, Nikol Mladkova2, Vida Saeedi1 1Urmia University of Medical Sciences, Urmia, Iran; 2Institute of Cell and Molecular Science, London, UK Background: There is a need to elucidate what affects the implantation and early pregnancy course in pregnancies conceived with assisted reproductive technology (ART) so that pregnancy rates and outcomes can be improved. Our aim was to determine the role of maternal Helicobacter pylori infection. Material and methods: We did a prospective study of 187 infertile couples undergoing intracytoplasmic sperm injection (ICSI) and segregated those according to underlying infertility etiology. We assessed the status of H. pylori IgG antibodies and anti-CagA IgG antibodies by ELISA assay. All pregnancies were followed for early pregnancy loss (EPL, first 12 weeks). Results: The
TY - JOUR. T1 - Helicobacter pylori infection in pregnant women in four districts of Uganda. T2 - Role of geographic location, education and water sources. AU - Baingana, Rhona Kezabu. AU - Kiboko Enyaru, John. AU - Davidsson, Lena. PY - 2014/9/4. Y1 - 2014/9/4. N2 - Background: The prevalence of Helicobacter pylori infection varies in relation to geography, ethnicity and socioeconomic factors. Available data on the prevalence of Helicobacter pylori infection in Uganda are not representative of the general population. We sought to describe the epidemiology of this infection in pregnant women in Uganda to provide background data for a study into the effect of H. pylori infection during pregnancy on the hematological response to iron supplementation.Methods: Using a cross-sectional design, H. pylori infection was assessed by the stool antigen test among 447 pregnant women attending antenatal care clinics in Apac, Mbale, Mbarara and Rakai Districts which are in different geographical regions in ...
TY - JOUR. T1 - Clinical outcomes of standard triple therapy plus probiotics or concomitant therapy for Helicobacter pylori infection. AU - Jung, Jae Hyun. AU - Cho, In Kuk. AU - Lee, Chang Hee. AU - Song, Gwan Gyu. AU - Lim, Ji Hyun. PY - 2018/3/1. Y1 - 2018/3/1. N2 - Background/Aims: The efficacy of standard triple therapy (STT) in treating Helicobacter pylori infection has decreased. Many investigators have attempted to increase the eradication rate. We investigated the outcomes of concomitant therapy (CT) and STT combined with probiotics (STP) as a first-line treatment for H. pylori infection. Methods: We reviewed the medical records of 361 patients who received either STP (n=286) or CT (n=75). The STP group received STT combined with a probiotic preparation for 1 week. The CT group received STT and metronidazole for 1 week. Results: The intention-to-treat and per-protocol eradication rates were 83.6% (95% confidence interval [CI], 79.0 to 87.7) and 87.1% (95% CI, 81.2 to 89.7) in the STP ...
Helicobacter pylori infection attacks the mucus of the stomach since it survives in acidic environment. However, the symptoms do not manifest in the … there is also a loss of appetite, and weight loss, blood in the stool in 25% of the …. Mom with Rare Blood Disorder Adopts 3 Kids with Same Condition ; 11 Weird Things People Have Swallowed ; Weight-Loss Procedure Makes Stomach into Accordion …. weight loss may affect bone mass and result in bone mineral density changes (BMD) and osteoporosis (2-6). Helicobacter pylori (H.pylori) which is a known cause of gastritis and peptic ulcer disease is associated with …. Journal of Gastroenterology, 134, 306-323. 5. Smoot, D.T. (1997) How Does Helicobacter Pylori Cause Mucosal Damage? Direct Mechanisms. Gastroenterology, 113, S31-S34. 6. Monzón, H., Forne, M., Rosinach, M., Loras, C., et …. Helicobacter pylori (H. pylori) infection - Comprehensive overview covers symptoms, treatment of infection with Helicobacter pylori bacteria.. Many of these ...
TY - JOUR. T1 - Antibiotic resistance in Helicobacter pylori strains and its effect on H. pylori eradication rates in a single center in Korea. AU - An, Byoungrak. AU - Moon, Byung Soo. AU - Kim, Heejung. AU - Lim, Hyun Chul. AU - Lee, Yong Chan. AU - Lee, Gyusang. AU - Kim, Sa Hyun. AU - Park, Min. AU - Kim, Jong Bae. PY - 2013/12/4. Y1 - 2013/12/4. N2 - Background: Clarithromycin, amoxicillin, metronidazole, tetracycline, and levofloxacin have been commonly used for the eradication of Helicobacter pylori. We compared the change in antibiotic resistance of H. pylori strains during two separate periods and investigated the effect of antibiotic resistance on H. pylori eradication. Methods: H. pylori strains were isolated from 71 patients between 2009 and 2010 and from 94 patients between 2011 and 2012. The distribution of minimal inhibitory concentration (MIC) of 5 antibiotics was assessed using the agar dilution method, and H. pylori eradication based on the antimicrobial susceptibility of the ...
Best helicobacter pylori diagnosis test and helicobacter pylori diagnosis test manufacturers - 151 helicobacter pylori diagnosis test Manufacturers & Suppliers from China
Helicobacter pylori infection causes peptic ulcers, gastric mucosa-associated lymphoid tissue lymphoma, and gastric cancer [1]. Most international guidelines recommended triple-therapy regimens consisting of a proton pump inhibitor (PPI), clarithromycin, and amoxicillin/metronidazole for at least 7 days for the eradication of H. pylori [2-4]. However, the eradication frequency of standard triple therapy has fallen to less than 80% in many countries because of the rising prevalence of clarithromycin resistance [5-7]. The rate of clarithromycin resistance is reported to be as high as 37.3% in Korea. Consequently, the first-line eradication rate of triple therapy has been shown to be 74% according to a national database [8, 9]. Despite this issue, the standard triple-therapy regimen is still recommended for first-line therapy in Korea according to the revised guidelines, and it is the only regimen reimbursed by the Korean National Health Insurance Service [10].. Several strategies, including ...
The severity of Helicobacter pylori-related diseases varies greatly among infected individuals and seems to be influenced by both host and bacterial factors. Infection with a cytotoxin-associated gene pathogenicity island (Cag PAI)-positive H. Pylori strain causes a higher grade of gastric mucosal inflammation than an infection caused by a negative strain. Furthermore, such an infection is associated with severe atrophic gastritis and gastric adenocarcinoma. NOD1 protein is a cytosolic pattern recognition receptor that responds to peptidoglycan delivered by H. Pylori cag pathogenicity island. The aim of this study is to investigate whether the presence of the NOD1 G796A polymorphism has any influence on the clinical outcomes of Cag PAI-positive H. Pylori. Both Helicobacter pylori and CagA-positive 150 patients were considered eligible for the study. In this selected group, NOD1 G796A was detected by using polymerase chain reaction/restriction fragment length polymorphism. Activity and severity ...
According to the report, Helicobacter Pylori Diagnostics Market Size, Share & Trends Analysis Report By Technology (Immunoassays, POC, Molecular Diagnostics), By End User, By Region, And Segment Forecasts, 2019 - 2026, increasing demand for personalized antibiotic therapy and improved cost-effectiveness of diagnosis of helicobacter pylori infection are some of the factors driving the growth.. Helicobacter pylori infections are particularly prevalent in developing nations. Some of the key factors including the lack of proper water supply, poor sanitation, dense population, and poor personal hygiene can be attributed to the spread of these infections. Rising awareness regarding H. pylori infections in the cohort is one of the factors propelling growth of the Helicobacter pylori diagnostics market.. Easy accessibility and affordability of antibiotics along with short treatment duration will further boost the adoption antibiotics as well as the demand for pre and post monitoring tests. ...
TY - JOUR. T1 - Ulcer site and complications. T2 - Relation to Helicobacter pylori infection and NSAID use. AU - Al-Assi, M. T.. AU - Genta, R. M.. AU - Karttunen, T. J.. AU - Graham, D. Y.. PY - 1996/2. Y1 - 1996/2. N2 - Background and Study Aim: The aim of this study was to investigate the relationship between the presence and location of ulcers, H. pylori infection, NSAID use, and major upper gastrointestinal tract bleeding. Patients and Methods: We studied 100 consecutive patients with duodenal ulcers and 145 consecutive patients with benign gastric ulcers. Results: Ninety-nine percent of the duodenal ulcer patients and 92% of the gastric ulcer patients had H. pylori infection; all gastric ulcer patients without H. pylori infection were using NSAIDs. Gastric ulcers in patients with H. pylori infection who were not using NSAIDs were more likely to be on the lesser curvature (85%) than ulcers in NSAID users who had no H. pylori infection (36%) (p , 0.01). Conversely, only 5% of gastric ulcers ...
Murakami, K., Kodama, M. and Fujioka, T. (2006) Latest Insights into the Effects of Helicobacter Pylori Infection on Gastric Carcinogenesis. World Journal of Gastroenterology, 12, 2713-2720.
We read with great interest the paper by Choe and colleagues which investigated a possible relationship betweenHelicobacter pylori infection, iron deficiency anaemia (IDA), and subnormal growth at puberty.1 The authors concluded that H pylori infection and related IDA, rather than bacterial infection alone, might cause delayed pubertal growth. However, we believe that these results need some consideration.. H pylori infection may cause IDA in different ways: (a) the bacterium can cause a decrease in the gastric juice of the concentration of ascorbic acid, which is the best promoter of non-heme iron absorption2; (b) H pylori may increase iron demand because iron is an essential bacterial growth factor; (c) H pyloricontains a 19.6 kDA protein resembling ferritin with a binding activity for heme iron in erythrocytes3; (d) acute or chronic blood loss and IDA are associated with typical H pylori related gastroduodenal lesions. In Choes study, the treatment of H pylori infection with antibiotics (but ...
Background:. Helicobacter pylori (HP) play an important role in the pathogenesis of chronic gastritis, peptic ulcer diseases as well as gastric cancer. Helicobacter pylori eradication is a critical strategy to reduce aforementioned conditions. Proton-pump inhibitor (PPI)-based triple therapy (Standard dose PPIs+ Clarithromycin 1g/D + Amoxycillin 2g/D or Metronidazole 800 mg/D) is recommended as a frontline treatment in current guidelines for HP eradication, both from Thai and Second Asia-Pacific Consensus Guideline for H.pylori 2009. Unfortunately, it has been reported an unacceptably low eradication rate (,85%) of this regimen in a tertiary care hospital in Thailand. This occurrence is not surprised as the worldwide efficacy of this regimen had decreased to 50-75%. Of this, Clarithromycin resistance has been a major cause of the treatment failure.. Sequential therapy (ST) which consists of standard dose PPIs + amoxycillin 2 g/D for 5 days with 5 additional days of clarithromycin 1g/D + ...
Background:. Helicobacter pylori (HP) play an important role in the pathogenesis of chronic gastritis, peptic ulcer diseases as well as gastric cancer. Helicobacter pylori eradication is a critical strategy to reduce aforementioned conditions. Proton-pump inhibitor (PPI)-based triple therapy (Standard dose PPIs+ Clarithromycin 1g/D + Amoxycillin 2g/D or Metronidazole 800 mg/D) is recommended as a frontline treatment in current guidelines for HP eradication, both from Thai and Second Asia-Pacific Consensus Guideline for H.pylori 2009. Unfortunately, it has been reported an unacceptably low eradication rate (,85%) of this regimen in a tertiary care hospital in Thailand. This occurrence is not surprised as the worldwide efficacy of this regimen had decreased to 50-75%. Of this, Clarithromycin resistance has been a major cause of the treatment failure.. Sequential therapy (ST) which consists of standard dose PPIs + amoxycillin 2 g/D for 5 days with 5 additional days of clarithromycin 1g/D + ...
For thousands of years humans have lived in symbiosis with Helicobacter pylori. This infection is acquired mainly during childhood and, despite it represents one of the most common infections in humans, only a minority of infected people may develop health issues and life-threatening diseases. For diagnosing Helicobacter pylori infection in children we can use, at first, non-invasive diagnostic tests, if clinical pattern and/or history are of suspicion. Then, invasive tests i.e. gastroscopy are necessary to confirm the infection. As antibiotics are not widely available in children affected by Helicobacter pylori infection, they should be chosen based on individual antibiotic susceptibility testing obtained by gastric biopsy specimens or the local antibiotic resistance pattern, in empirical treatment is chosen. Test and treat strategy in children should be avoided. In this brief review we summarize how and in which children the infection should be investigate and which the most appropriate ...
TY - JOUR. T1 - Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates. AU - Maeda, S.. AU - Yoshida, H.. AU - Ikenoue, T.. AU - Ogura, K.. AU - Kanai, F.. AU - Kato, Nobuyuki. AU - Shiratori, Y.. AU - Omata, M.. PY - 1999. Y1 - 1999. N2 - Background - cag pathogenicity island (PAI) is reported to be a major virulence factor of Helicobacter pylori. Aim - To characterise cagA and the cag PAI in Japanese Hpylori strains. Methods - H pylori isolates from Japanese patients were evaluated for CagA by immunoblot, for cagA transcription by northern blot, and for cagA and 13 other cag PAI genes by Southern blot. cagA negative strains from Western countries were also studied. Induction of interleukin-8 secretion from gastric epithelial cells was also investigated. Results - All Japanese strains retained cagA. Fifty nine of 63 (94%) strains had all the cag PAI genes. In the remaining four, cag PAI was partially deleted, lacking cagA transcripts and not producing CagA protein. ...
TY - JOUR. T1 - Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology. AU - Tsai, Huei-Fang. AU - Hsu, Ping Ning. PY - 2010/7. Y1 - 2010/7. N2 - Helicobacter pylori infection is associated with an inflammatory response in the gastric mucosa, leading to chronic gastritis, peptic ulcers, gastric carcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphomas. Recent studies have shown that apoptosis of gastric epithelial cells is increased during H. pylori infection. Apoptosis induced by microbial infections are factors implicated in the pathogenesis of H. pylori infection. The enhanced gastric epithelial cell apoptosis in H. pylori infection has been suggested to play an important role in the pathogenesis of chronic gastritis and gastric pathology. In addition to directly triggering apoptosis, H. pylori induces sensitivity to tumor-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in ...
Helicobacter pylori infection is the most important etiologic factor in chronic gastritis and gastroduodenal ulcer disease. Approximately 30% of patients with dyspepsia in North America are infected with H pylori; the annual incidence of new infections is about 0.5 per 100 persons in the susceptible population. In the developing world, prevalence among patients with dyspepsia is 80% to 90%, and the annual incidence of new infections is 3 or more per 100 susceptible persons. Presence of H pylori is closely related to development of gastric cancer. Eradication of the organism results in ulcer healing and reduces risk of ulcer recurrence and complications. Diagnostic methods for H pylori infection are direct or invasive (identifying the microorganism by gastric biopsy) and indirect or noninvasive (detecting certain characteristics of the bacteria). The latter can include the capacity of H pylori to hydrolyze urea (eg, urea breath test [UBT]) or quantification of specific antibodies (eg, various ...
TY - JOUR. T1 - Association of Helicobacter pylori infection and diet on the risk of gastric cancer. T2 - A case-control study in Hawaii. AU - Epplein, Meira. AU - Nomura, Abraham M.Y.. AU - Hankin, Jean H.. AU - Blaser, Martin J.. AU - Perez-Perez, Guillermo. AU - Stemmermann, Grant N.. AU - Wilkens, Lynne R.. AU - Kolonel, Laurence N.. PY - 2008/10/1. Y1 - 2008/10/1. N2 - Objective: The risk factors most strongly associated with gastric cancer are the gastric bacteria Helicobacter pylori and diet. Utilizing data from a case-control study among residents in Hawaii, we examined the association of diet, presence of H. pylori, and non-cardia gastric cancer risk. Methods: Serum taken at diagnosis for cases (n = 212) and at interview for controls (n = 336) was assayed for IgG antibodies to H. pylori group antigens and to a recombinant fragment of the cytotoxin-associated antigen A (CagA) protein, and subjects completed food frequency questionnaires. Risk measures were calculated using logistic ...
TY - JOUR. T1 - Does Helicobacter pylori infection increase the risk of Barretts esophagus and esophageal adenocarcinoma?. AU - Erőss, Bálint. AU - Tinusz, Benedek. AU - Farkas, Nelli. AU - Hegyi, P.. PY - 2018/1/1. Y1 - 2018/1/1. UR - http://www.scopus.com/inward/record.url?scp=85053805073&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85053805073&partnerID=8YFLogxK. U2 - 10.1111/hel.12539. DO - 10.1111/hel.12539. M3 - Article. C2 - 30251295. AN - SCOPUS:85053805073. JO - Helicobacter. JF - Helicobacter. SN - 1083-4389. ER - ...
This article summarizes the main conclusions drawn from the presentations on Helicobacter pylori infection at Digestive Disease Week 2011. In developed countries, the prevalence of H. pylori infection has decreased, but seems to have reached a plateau at a fairly high level. Antibiotic resistance is increasing in several countries. H. pylori eradication does not contribute to the development of gastroesophageal reflux disease or worsen its course. The frequency of idiopathic peptic ulcers seems to be increasing. H. pylori eradication eliminates almost all episodes of peptic ulcer rebleeding; nevertheless, the use of non-steroidal anti-inflammatory drugs or H. pylori reinfection can lead to bleeding recurrence. H. pylori-negative patients with peptic ulcer bleeding more frequently have bleeding recurrences and higher mortality. In each particular population, there is a close correlation between the prevalence of H. pylori infection and the incidence of gastric cancer. H. pylori eradication is ...
I am troubled by Laine and colleagues conclusion that there is little support for the use of H. pylori eradication therapy in patients with nonulcer dyspepsia (1). Since infected persons have a two- to sixfold increased risk for gastric cancer and certain types of lymphoma, isnt it reasonable to therefore offer curative therapy? Do we really have longitudinal studies of sufficient duration to know the actual long-term risks associated with continued H. pylori infection? In the same issue, the findings of Ohkusa and associates that precancerous gastric lesions improved after eradication of H. pylori(2) certainly support the premise of long-term benefit ...
A systematic review and economic analysis of the cost-effectiveness of H pylori eradication therapy in non-ulcer dyspepsia (NUD) Conference Paper ...
La résistance à lamoxicilline reste exceptionnelle (, 1 %). Rescue therapy with rifabutin after multiple H. pylori treatment failures (abstract).Intact H. pylori bacteria induced IL-8 secretion from cells expressing TLR2 and CD14 but not from cells expressing TLR4 and CD14 or CD14 alone (Fig. (Fig.2A). 2A).Amoxicillin; Anti-Ulcer Agents; Omeprazole; Bacterial Proteins; Bismuth; Antigens, Bacterial;. i have had h pylori for 6 months. i took treatment for it last month.HELICOBACTER PYLORI. Les infections à H. pilori,. In Vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of.HELICOBACTER PYLORI - Natural treatments for the eradication of the HP bacterium. Helicobacter pylori (HP) is a bacterium which infects the mucous lining of the human.. Les CMI de H. pylori & Iamoxicilline sont en general tres basses. Keller J.J. Rauws E.AJ Tytgat G.NJ. Treatment of Helicobacter pylori infection:.H. pylori eradication treatment to patients with a history ...
BACKGROUND AND AIMS: Helicobacter pylori is a major cause of peptic ulcers and gastric cancer. Vaccine development is progressing but there is concern that immunisation may exacerbate Helicobacter induced gastritis: prophylactic immunisation followed by challenge with H felis or H pylori can induce a more severe gastritis in mice than seen with infection alone. The aim of this study was to investigate the relationship between immunity to Helicobacter infection and post-immunisation gastritis. METHODS: (1) C57BL/6 mice were prophylactically immunised before challenge with either H felis or H pylori. Histopathology and colonisation were assessed one month post-challenge. (2) C57BL/6 mice were prophylactically immunised against H felis infection and gastritis assessed up to 18 months post-challenge. RESULTS: Prophylactic immunisation induced a reduction in bacterial colonisation following H felis challenge which was associated with increased severity of active gastritis with neutrophil infiltration ...
A 28-year-old male patient presented in January 1996 with the symptoms of ulcer like dyspepsia. There was no significant abnormality on physical examination, laboratory testing and abdominal ultrasound. Histology examination of the biopsy specimen taken during the upper endoscopy revealed Helicobacter pylori associated active gastritis only in the corporal part of the stomach. After two weeks eradication therapy (Omeprazole, Amoxicillin) he was well. Three months later, at the control endoscopy, granulomatous gastritis of the corporal localization was detected, without Helicobacter pylori present. Antral mucosa appeared normal, both, on endoscopy and histology examination. In July 1996 he started with cramping abdominal pain, mild periodical fever and episodes of watery diarrhea. In laboratory results we found nonspecific signs of inflammation. We repeated upper endoscopy, colonoscopy and enteroclysis--with evidence of segmental stenotic lesions of the upper part of ileum and jejunum. Again, we ...
Background: Commercial serological tests for the detection of Helicobacter pylori infection must be locally validated. We evaluated the accuracy of five commercial tests in the Chinese population. Methods: Serum samples were collected from patients referred for upper endoscopy. Antral biopsies were taken for histological examination and culture of H. pylori. The gold standard for diagnosing H. pylori infection was positive histological staining and/or positive H. pylori culture. The serum samples were tested for H. pylori antibodies using the following tests: (i) Cobas Core Anti-H. pylori EIA: (ii) GAP IgG; (iii) GAP IgM; (iv) H. pylori microwell EIA (Quidel): and (v) Premier H. pylori. The sensitivity, specificity and accuracy of each test was calculated according to the manufacturers instructions or according to a new cut-off value. Results: A total of 158 patients were recruited amongst whom 114 (72%) were H. pylori-positive. Indeterminate results varied from 7% to 19%. The accuracy of the ...
Epidemiological and clinical studies in high income countries have suggested that Helicobacter pylori (H. pylori) may cause anaemia, but evidence is lacking from low income countries.We examined associations between H. pylori infection in early childhood and anaemia at the age of 6.5 years in an Ethiopian birth cohort. In 2011/12, 856 children (85.1 % of the 1006 original singletons in a population-based birth cohort) were followed up at age six and half. An interviewer-led questionnaire administered to mothers provided information on demographic and lifestyle variables. Haemoglobin level and red cell indices were examined using an automated haematological analyzer (Cell Dyn 1800, Abbott, USA), and stool samples analyzed for H. pylori antigen. The independent effects of H. pylori infection (measured at age 3.5 and 6.5 years) on anaemia, haemoglobin level, and red cell indices (measured at age 6.5 years) were determined using multiple logistic and linear regression. The prevalence of anemia was 34.8 %
TY - JOUR. T1 - How to manage Helicobacter pylori after sequential therapy failure?. AU - Hassan, Cesare. AU - Zullo, A. AU - Cristofari, F. AU - Iegri, C. AU - De Francesco, V.. PY - 2010. Y1 - 2010. N2 - N/A. AB - N/A. KW - 2-Pyridinylmethylsulfinylbenzimidazoles. KW - Adult. KW - Aged. KW - Amoxicillin. KW - Anti-Bacterial Agents. KW - Child. KW - Clinical Trials as Topic. KW - Drug Administration Schedule. KW - Drug Therapy, Combination. KW - Enzyme Inhibitors. KW - Helicobacter Infections. KW - Helicobacter pylori. KW - Humans. KW - Ofloxacin. KW - Treatment Failure. KW - Treatment Outcome. KW - 2-Pyridinylmethylsulfinylbenzimidazoles. KW - Adult. KW - Aged. KW - Amoxicillin. KW - Anti-Bacterial Agents. KW - Child. KW - Clinical Trials as Topic. KW - Drug Administration Schedule. KW - Drug Therapy, Combination. KW - Enzyme Inhibitors. KW - Helicobacter Infections. KW - Helicobacter pylori. KW - Humans. KW - Ofloxacin. KW - Treatment Failure. KW - Treatment Outcome. UR - ...
TY - JOUR. T1 - Transforming growth factor-B1 and matrix metalloproteinase-7 promoter variants induce risk for Helicobacter pylori-associated gastric precancerous lesions. AU - Achyut, B R. AU - Ghoshal, Uday C. AU - Moorchung, Nikhil. AU - Mittal, Balraj. PY - 2009/6. Y1 - 2009/6. N2 - The expression of growth factors, proteolytic enzymes, fibrogenic factors, and cytokines is altered in the Helicobacter pylori-infected gastric mucosa. Therefore, we aimed to evaluate the association of functional promoter variants of transforming growth factor (TGF)-B1 and matrix metalloproteinase (MMP)-7 genes with gastritis and gastric precancerous lesions. After upper gastrointestinal endoscopy, a total of 130 rapid urease test-positive patients with nonulcer dyspepsia were examined for H. pylori infection using modified Giemsa stain and IgG anti-CagA ELISA. All patients and 200 asymptomatic controls were genotyped for TGF-B1 (-509 C,T) and MMP-7 (-181 A,G) substitutions using PCR-RFLP. The genotype and ...
Helicobacter pylori infection affects more than half of the worlds population. It is generally acquired during childhood with no symptoms but has long- term clinical sequelae. This study estimated the prevalence of H. pylori infection amongst children in a rural environment in Africa. We conducted a cross-sectional study over a four (4)-month period within two rural communities. 240 asymptomatic children were tested using lateral flow immunochromatographic assay for the qualitative detection of H. pylori antigen in a fecal specimen. Statistical analysis and processing was done using Stata version 11. The mean age of the participants was 10.5 ± 2.7 years with the predominant age range being 8-10 years (34.6%), and a mean household size of 7.1 ± 1.7. The study population showed a female preponderance of 57.1%. 88% of the H. pylori positive children lacked pipe and borehole drinking water. All of the positive H. pylori children practiced open-air defecation. The overall prevalence of H. pylori infection
There have been conflicting reports on the effect of Helicobactor pylori eradication on gastric metaplasia in the duodenal bulb DGM. In the present study, we have investigated the relationships between DGM and H. pylori by examining whether or not H. pylori-positive patients had more DGM than H. pylori-negative patients with nonulcer dyspepsia...
Factors affecting Helicobacter pylori eradication rate with omeprazole (OME), clarithromycin (CL), and amoxicillin (AMO) have not been extensively studied. We have investigated the effect of age, sex,
BACKGROUND: In epidemiological studies, Helicobacter pylori infection is usually detected by enzyme-linked immunosorbent assay (ELISA). However, infection can spontaneously clear from the mucosa during the progression of atrophy and could lead to substantial under-detection of infection and underestimation of its effect on gastric cancer (GC) risk. Antibodies detected by western blot are known to persist longer after the loss of the infection. METHODS: In a nested case-control study from the Eurogast-EPIC cohort, including 88 noncardia GC cases and 338 controls, we assessed the association between noncardia GC and H. pylori infection comparing antibodies detected by western blot (HELICOBLOT2.1) to those detected by ELISA (Pyloriset EIA-GIII(®)). RESULTS: By immunoblot, 82 cases (93.2%) were H. pylori positive, 10 of these cases (11.4%) were negative by ELISA and only 6 cases (6.8%) were negative by both ELISA and immunoblot. Multivariable odds ratio (OR) for noncardia GC comparing immunoglobulin G
TY - JOUR. T1 - Seven days triple therapy for eradication of Helicobacter pylori does not alter the disease activity of patients with inflammatory bowel disease. AU - Shinzaki, Shinichiro. AU - Fujii, Toshimitsu. AU - Bamba, Shigeki. AU - Ogawa, Maiko. AU - Kobayashi, Taku. AU - Oshita, Masahide. AU - Tanaka, Hiroki. AU - Ozeki, Keiji. AU - Takahashi, Sakuma. AU - Kitamoto, Hiroki. AU - Kani, Kazuhito. AU - Nanjo, Sohachi. AU - Sugaya, Takeshi. AU - Sakakibara, Yuko. AU - Inokuchi, Toshihiro. AU - Kakimoto, Kazuki. AU - Yamada, Akihiro. AU - Yasuhara, Hisae. AU - Yokoyama, Yoko. AU - Yoshino, Takuya. AU - Matsui, Akira. AU - Nakamura, Misaki. AU - Tomizawa, Taku. AU - Sakemi, Ryosuke. AU - Kamata, Noriko. AU - Hibi, Toshifumi. PY - 2018/10/1. Y1 - 2018/10/1. N2 - Background/Aims: The influences of Helicobacter pylori eradication therapy on the disease course of inflammatory bowel disease (IBD) are still unclear. We therefore conducted a multicenter, retrospective cohort study to evaluate the ...
TY - JOUR. T1 - Does Helicobacter pylori infection increase gastric sensitivity in functional dyspepsia?. AU - Mearin, F.. AU - Ribot de, X.. AU - Balboa, A.. AU - Salas, A.. AU - Varas, M.J.. AU - Cucala, M.. AU - Bartolomé, R.. AU - Armengol, J.R.. AU - Malagelada, J.R.. PY - 1995/1/1. Y1 - 1995/1/1. M3 - Article. VL - 37. SP - 47. EP - 51. JO - Gut. JF - Gut. SN - 0017-5749. ER - ...
The modern methods used in medical research are increasingly demonstrating the importance of the human microbiome for a persons general health. The microbiome refers to all the bacteria that live in an organ system or ecosystem. It is constantly adapting to changes in the ecosystem, such as changes in lifestyle or eating habits, for example.. A few months ago, working in collaboration with the Austrian Society of Gastroenterology and Hepatology, a team of researchers led by infectionologist Christoph Steininger from the Division of Infectious Diseases and Tropical Medicine at MedUni Viennas Department of Medicine I conducted a large-scale study into antibiotic resistance of Helicobacter pylori in Austria.. Helicobacter pylori is a common bacterium that can cause gastritis and stomach cancer. Symptoms can vary a great deal, ranging from loss of appetite and nausea through to upper abdominal pain. It was found that Helicobacter pylori infection is often resistant to standard antibiotics and ...
Helicobacter pylori (H. pylori) infection triggers a sequence of gastric alterations starting with an inflammation of the gastric mucosa that, in some cases, evolves to gastric cancer. Efficient vaccination has not been achieved, thus it is essential to find alternative therapies, particularly in the nutritional field. The current study evaluated whether curcumin could attenuate inflammation of the gastric mucosa due to H. pylori infection. Twenty-eight C57BL/6 mice, were inoculated with the H. pylori SS1 strain; ten non-infected mice were used as controls. H. pylori infection in live mice was followed-up using a modified 13C-Urea Breath Test (13C-UBT) and quantitative real-time polymerase chain reaction (PCR). Histologically confirmed, gastritis was observed in 42% of infected non-treated mice at both 6 and 18 weeks post-infection. These mice showed an up-regulation of the expression of inflammatory cytokines and chemokines, as well as of toll-like receptors (TLRs) and MyD88, at both time ...
TY - JOUR. T1 - Usefulness of magnifying narrow-band imaging endoscopy in the helicobacter pylori-related chronic gastritis. AU - Okubo, Masaaki. AU - Tahara, Tomomitsu. AU - Shibata, Tomoyuki. AU - Nakamura, Masakatsu. AU - Kamiya, Yoshio. AU - Yoshioka, Daisuke. AU - Maeda, Yoshiteru. AU - Yonemura, Joh. AU - Ishizuka, Takamitsu. AU - Arisawa, Tomiyasu. AU - Hirata, Ichiro. PY - 2011/1/1. Y1 - 2011/1/1. N2 - Combining the narrow-band imaging (NBI) system and magnifying endoscopy allows simple and clear visualization of microscopic structures of the superficial mucosa and its capillary patterns, which may be useful for precise endoscopic diagnosis in the gastrointestinal tract, being more closely to histopathological diagnosis. In the non-neoplastic gastric mucosa, there have been reports showing a potential usefulness of magnifying NBI for the diagnosis of Helicobacter pylori infection, degree of histological gastritis, and intestinal metaplasia. We have shown that magnifying NBI appearances ...
TY - JOUR. T1 - Helicobacter pylori strain types and risk of gastric cancer. T2 - A case-control study. AU - Enroth, H.. AU - Kraaz, W.. AU - Engstrand, L.. AU - Nyren, O.. AU - Rohan, T.. PY - 2000/10/16. Y1 - 2000/10/16. N2 - The aim of this novel endoscopy clinic-based case-control study was to explore the influence of different Helicobacter pylori strain types on the risk of gastric adenocarcinoma using isolated bacterial strains, tissue samples, and sera. We included 72 cases with gastric adenocarcinoma and 324 age- and sex-matched controls. Histological characterization, culture, molecular typing of H. pylori genes by PCR (cagA/vacA), conventional IgG ELISA, and immunoblotting (Western blot) for the CagA and VacA proteins were performed. With four tests combined, H. pylori infection was detected in 57 (79%) cases and 213 (66%) controls. A positive association between H. pylori infection and gastric cancer risk was found [odds ratio (OR), 2.1; 95% confidence interval, 1.1-3.9]. Type I (OR, ...
This review presents a critical evaluation of the role of Helicobacter pylori eradication in the management of peptic ulcer disease and non-ulcer dyspepsia. On current evidence, H. pylori eradication therapy seems likely to emerge as the most rational and cost-effective treatment for duodenal ulcer. The role of H. pylori eradication in the treatment of gastric ulcer and non-ulcer dyspepsia is unclear and requires further study. The emerging problem of antibiotic resistance in H. pylori is of major clinical importance and a prime cause of treatment failure. There is increasing evidence of a link between H. pylori and gastric cancer but it is premature to recommend large-scale eradication of H. pylori as a valid strategy for the primary prevention of gastric cancer. The search continues for the ideal H. pylori eradication regimen.. ...
Peptic ulcer disease, Helicobacter pylori infection and chronic gastritis - Related resources answers are found in the Evidence-Based Medicine Guidelines powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Increasing resistance to clarithromycin and nitroimidazole is the main cause of failure in the Helicobacter pylori eradication. The ideal retreatment regimen remains unclear, especially in developing countries, where the infection presents high prevalence and resistance to antibiotics. The study aimed at determining the efficacy, compliance and adverse effects of a regimen that included furazolidone, levofloxacin and lansoprazole in patients with persistent Helicobacter pylori infection, who had failed to respond to at least one prior eradication treatment regimen. This study included 48 patients with peptic ulcer disease. Helicobacter pylori infection was confirmed by a rapid urease test and histological examination of samples obtained from the antrum and corpus during endoscopy. The eradication therapy consisted of a 7-day twice daily oral administration of lansoprazole 30 mg, furazolidone 200 mg and levofloxacin 250 mg. Therapeutic success was confirmed by a negative rapid urease test, histological
BACKGROUND/AIMS A two-year, prospective, nationwide multicenter study was undertaken to evaluate the effect of Helicobacter pylori eradication on the development of reflux esophagitis (RE) and gastroesophageal reflux disease (GERD) symptoms in the Korean population. METHODS In total, 1,489 subjects without RE were enrolled at the outpatient clinics of 12 tertiary hospitals nationwide, and 452 subjects underwent follow-up (F/U) for 2 years to evaluate the development of RE and GERD symptoms. RESULTS RE was found in 33 subjects (7.3% of 452 subjects) and 14 subjects (7.3% of 192 subjects) during the first and second year of F/U, respectively. H. pylori status was not associated with the development of RE. RE was found in six (9.0%) of 67 H. pylori-negative patients, in 26 (11.2%) of 233 eradicated subjects and in eight (7.0%) of 114 noneradicated subjects (p=0.532). Multivariate analysis showed that age ≥60 years (odds ratio [OR], 7.11; 95% confidence interval [CI], 1.92 to 26.41), alcohol
Teh, M., Tan, K.B., Seet, B.L., Yeoh, K.G. (2002). Study of p53 immunostaining in the gastric epithelium of cagA-positive and cagA-negative Helicobacter pylori gastritis. Cancer 95 (3) : 499-505. [email protected] Repository. https://doi.org/10.1002/cncr. ...
In 1991 Wotherspoon et al 1 showed a close association between Helicobacter pylori infection and gastric mucosa-associated lymphoid tissue (MALT) lymphoma (GML) with the organism present in 92% of cases. Other studies have shown this association to be varying between 42% and 100%. In vitro studies at that time showed that lymphoma cell proliferation was associated with the presence of H. pylori mediated through specific tumour infiltrating T cells in a contact dependant manner. In the light of this finding Wotherspoon et al 1 were able to demonstrate that eradication of H. pylori induced lymphoma regression. In a recent Gut article, Nakamura et al 2 demonstrated that H. pylori eradication therapy can result in durable lymphoma regression in the majority of cases. However, absence of H. pylori infection is a known predictive factor for eradication resistance.3 Prevalence of H. pylori has shown signs of decrease especially among Western populations. A decline in the number of GML H. ...
Background. Our aim was to evaluate the accuracy of the stool antigen test and the optimal time point for detecting Helicobacter pylori infection in a Mongolian gerbil model. Methods. We inoculated 8-week-old Mongolian gerbils with H. pylori (Vac A (+)/CagA(+)). The gerbil-infected model was developed as follows: H. pylori was put into broth (about 109 CFU/ml), and 50 gerbils were then fed with 1 ml intragastrically twice within a 3-day interval. Another ten gerbils were fed broth only. Twenty-six weeks after the inoculation, the gerbils were killed. The gastric mucosa was sampled for a series of examinations including culture, histology, rapid urease test, and polymerase chain reaction. Stool samples for a stool antigen test, H. pylori-specific stool antigen assay (HpSA), were collected during weeks 4, 6, 8, 12, and 26 after inoculation. Of the 50 gerbils inoculated with H. pylori, the inoculation was successful in 88%. Severe active gastritis, ulceration, and intestinal metaplasia were obvious.
TY - JOUR. T1 - Helicobacter pylori infection stimulates intestinalization of endocrine cells in glandular stomach of Mongolian gerbils. AU - Takenaka, Yoshiharu. AU - Tsukamoto, Tetsuya. AU - Mizoshita, Tsutomu. AU - Cao, Xueyuan. AU - Ban, Hisayo. AU - Ogasawara, Naotaka. AU - Kaminishi, Michio. AU - Tatematsu, Masae. PY - 2006/10. Y1 - 2006/10. N2 - Intestinal metaplasia has been investigated extensively as a possible premalignant condition for stomach cancer but its pathogenesis is still not fully understood. In the present study, we examined the relationship between endocrine and mucous cell marker expression periodically after Helicobacter pylori infection in the Mongolian gerbil model. The numbers of chromogranin A (CgA)-positive, gastrin-positive and gastric inhibitory polypeptide (GIP)-positive cells in H. pylori-infected groups was increased significantly compared with the non-infected case. However, CgA-positive and gastrin-positive cells then decreased from 50 through 100 ...
Little is known of the function of the T cells in the inflammatory infiltrate in Helicobacter pylori associated gastritis. This study thus measured T cell in vivo activation by enumerating the frequency of interferon gamma (IFN gamma) and interleukin 4 (IL 4) secreting cells isolated from the gastric antral mucosa in patients with or without gastritis and in H pylori positive and negative gastritis. Fifty four samples were examined for cytokine secretion. Four antral biopsy specimens from each patient (n = 51) were taken during diagnostic endoscopy. One was used to estimate histological gastritis and the presence of H pylori, and three of the samples were used to isolate T cells by enzymatic digestion. IFN gamma and IL 4 secreting cells were enumerated by ELISPOT. Thirty four samples had gastritis and 79% of those were H pylori positive. None of the samples from non-inflamed mucosa had H pylori. The numbers of IFN gamma secreting cells per 10(5) T cells were higher in gastritis than in normal ...
Background & alms: The main cause of chronic gastritis is Helicobacter pylori (H. pylori). Clinical manifestations of chronic gastritis are ulcer disease, gastric cancer and mucosa-associated lymphoma tissue (MALT) lymphoma in the stomach. It is uncertain whether gastritis can be diagnosed macroscopically at endoscopy. H. pylori infection may be diagnosed by several different methods, the accuracy of which needs to be explored. Some individuals with H. pylori related chronic gastritis will develop atrophy of the gastric mucosa. This condition is the main risk factor for cancer development and may also be associated with vitamin B12 deficiency leading to hyperhomocysteinaemia. The natural history of chronic gastritis in terms of development of atrophy and ulcer disease in the adult general population is largely unknown.. Material & methods: A sample of 50 I volunteers from the general population in the municipality of Linköping was examined with esophago-gastro-duodenoscopy (EGD) with biopsy. ...
Background: Smoking is hazardous to almost any organ in the body and has a harmful effect on the gastric mucosa. Objective: The main goal of this study was to evaluate the synergistic effect of smoking and H. pylori infection on gastric mucosal among dyspeptic Egyptian patients. Patients and Methods: A cross-sectional study was conducted among 240 consecutive patients with dyspepsia who underwent upper endoscopy and histopathological examination of gastric biopsies at Zagazig and Tanta University Hospital with H. pylori-positivity assessment by stool antigen and rapid urease test. Results: There were 60 smoker patients and 180 non-smoker patients. Erosive gastritis was more prevalent in smoker patients than non-smoker patients (46.7% versus 15.6%, p = 0.00). In H. pylori-positive patients (36.7% of all patients), smokers were more prevalent than non-smokers in the development of intestinal metaplasia (20% versus 0%, p = 0.003), erosive gastritis (80% versus 30%, p = 0.00), glandular atrophy (20% versus
Background: The prevalence of Helicobacter pylori (H. pylori) infection is reported to be more than 50% worldwide. It has been associated with peptic ulcer disease, gastric carcinoma, and mucosal-associated lymphoid tissue lymphoma. The seroprevalence of H. pylori varies greatly among societies and geographical locations. The objective of this study was to determine the seroprevalence and factors associated with H. pylori infection among dyspeptic patients in Afghanistan. Materials and Methods: This cross-sectional study was designed to determine the seroprevalence of H. pylori among dyspeptic patients in an outpatient clinic in Andkhoy, Afghanistan from January 2017 to April 2017. Data were obtained from patients using a questionnaire, including socio-demographic data and history of smoking and dyspeptic symptoms. Serum samples were also collected from the patients and tested for H. pylori antibodies using the enzyme-linked immunosorbent assay. Results: A total of 152 patients with dyspepsia were
To determine the frequency of Helicobacter pylori infection in patients with lichen planus presented to tertiary care hospital Hyderabad. Patiehts and Methods This cross sectional descriptive study of six months was carried at Liaquat University Hospital Hyderabad Sindh, Pakistan from February 2008 to July 2008. All patients above 12 years of age, of either gender, were known / already diagnosed and newly diagnosed cases of lichen planus (LP) were came through outdoor patient department (OPD), indoor patient and causality outdoor department (COD) were evaluated and enrolled in the study. All such patients were screened for Helicobacter pylori infection by Helicobacter pylori stool antigen (HpSA). For getting result the data was saved and analyzed in SPSS version 10.00. RESULT: One hundred and five patients (105) were identified as lichen planus and screened for Helicobacter pylori infection. The Helicobacter pylori stool antigen (HpSA) was positive in 81 (77%) subjects with mean age 42.89 � ...
Abstract: Prevalence of Helicobacter pylori infection in Indonesia was 36-46%. In Jakarta and Surabaya, the prevalence were 85,7%-93,9%. Helicobacter pylori infection play role in pathogenesis of pectic ulcers, chronic gastritis, carcinoma of gaster and gastric lymphoma. Epidemiologic study showed 80% of carcinoma of gaster related with H pylori infection.This study analyzed expression of anti-Helicobacter pylori in chronic gastritis, precancer lesion , and carcinoma of gaster. This study was a observational descriptive study with case control design. Thirty (30) samples from paraffin bloc that were diagnosed with chronic gastritis, precancer lesion, and carcinoma of gaster at Dokter Kariadi hospital in 2013 was stained by hematoxylin eosin, giemsa and immunohistochemistry of anti-helicobacter pylori. Data was analyzed by descriptive analysis. Thirty (30) samples were diagnosed as gastritis chronis 13 (43,3% ), pra cancer lesion(36.6%), and carcinoma(20.1%). Chronic gastritis can be occurred at ...
Antibiotic resistance among Helicobacter pylori clinical isolates in Lima, Peru Kevin F Boehnke,1 Manuel Valdivieso,2 Alejandro Bussalleu,3 Rachael Sexton,4 Kathryn C Thompson,1 Soledad Osorio,5 Italo Novoa Reyes,3 John J Crowley,4 Laurence H Bakerm,2 Chuanwu Xi1 1Department of Environmental Health Sciences, School of Public Health, 2Division of Hematology Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; 3Departamento Académico de Clínicas Médicas, Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Perú; 4Cancer Research and Biostatistics, Seattle, WA, USA; 5Dirección General de Salud Ambiental, Ministerio de Salud del Perú, Lima, Perú Objectives: Gastric carcinoma is the most common cancer and cause of cancer mortality in Peru. Helicobacter pylori, a bacterium that colonizes the human stomach, is a Group 1 carcinogen due to its causal relationship to gastric carcinoma. While eradication of H. pylori can help prevent gastric
Helicobacter pylori infection is very common worldwide and is an important cause of gastritis, peptic ulcer disease, gastric mucosa-associated lymphoid tissue lymphoma, and gastric adenocarcinoma. Since the eradication requires treatment with multidrug regimens, prevention of primary infection by a …
BACKGROUND Different therapeutic regimens were used for eradication of Helicobacter pylori, based on the cost, effectiveness and patients compliance. The aim of this study was the evaluation of licorice compared with bismuth in quadruple regimen on eradication of H. pylori in patients with peptic ulcer disease (PUD). MATERIALS AND METHODS In a double-blind clinical trial study, 60 patients with PUD and positive rapid urease test were enrolled. The patients were randomly allocated into two equal groups. In first group, licorice, amoxicillin, metronidazole and omeprazole and in the second (control) group, bismuth subsalicylate, amoxicillin, metronidazole and omeprazole were prescribed respectively, and 4 weeks after treatment, in order to evaluate H. pylori eradication, urea breath test was done in all patients. The outcome of the study was the preference usage of licorice as an effective medication for H. pylori eradication. RESULTS Mean age of the patients in the control and case groups were ...
Investigating distinct individual- and household-level risk factors for acquiring Helicobacter pylori (H. pylori) infection can inform disease prevention efforts and implicate possible routes of transmission. This study determined the magnitude of H. pylori infection among schoolchildren in Ziway, central Ethiopia and identified personal and household correlates of H. pylori infection in young Ethiopian children. A total of 434 schoolchildren participated in this cross-sectional study. Infection status was assessed using antigen and antibody rapid tests. Demographic and lifestyle information was obtained from parents via an interviewer-led questionnaire. Univariate and multivariate logistic regressions were performed to assess the relationships between potential individual- and household-level risk factors and H. pylori infection. The prevalence of H. pylori infection was 65.7% (285/434). Of the personal variables assessed, the age group 10-14 years was found to be significantly associated with higher
Solcia, E.; Fiocca, R.; Luinetti, O.; Villani, L.; Padovan, L.; Calistri, D.; Ranzani, G.N.; Chiaravalli, A.; Capella, C., 1996: Intestinal and diffuse gastric cancers arise in a different background of Helicobacter pylori gastritis through different gene involvement
China C13 Urea Breath Test Kits for Helicobacter Pylori (HP) Diagnositc, Find details about China Test Kits, Urea Breath Test Kits from C13 Urea Breath Test Kits for Helicobacter Pylori (HP) Diagnositc - Shenzhen Zhonghe Headway Bio-Sci & Tech Co., Ltd.
Background and objectives Different methods have been used for detection of Helicobacter pylori in patients with chronic gastritis but a little has been written about immunohistochemistry. The study done was to identify Helicobacter pylori in gastric biopsies of patients with chronic gastritis using the routine stains and immunohistochemistry.Methods In a twelve month period, from April 2008 to May 2009, 105 cases of chronic gastritis were studied. The routine hematoxylin and eosin stain and modified Giemsa stains Sheehans modified may method and immunohistochemistry automated staining machinefrom Ventana Company were performed.Results Chronic gastritis cases (n=105) included 35 (33.3%) mild, 51 (48.6%) moderate, and 19 (18.1%) marked inflammation. Active form gastritis was detected in 76 (72.4%) cases, glandular atrophy in 40 (38.1%) cases, and intestinal metaplasia in 19 (18.1%) cases. Theroutine hematoxylin- eosin and modified Giemsa stains gave 20 (19%) false positive and 13 (12.4%) ...
TY - JOUR. T1 - Detection of HCV RNA in gastric mucosa-associated lymphoid tissue by In situ hybridization. T2 - Evidence of a new extrahepatic localization of HCV with increased risk gastric MALT lymphoma. AU - Tursi, Antonio. AU - Brandimante, Giovanni. AU - Chiarelli, Francesco. AU - Spagnoli, Anna. AU - Torello, Monica. PY - 2002/1/1. Y1 - 2002/1/1. N2 - OBJECTIVES: Mucosa-associated lymphoid tissue (MALT) is absent in the normal gastric mucosa but it can develop in several conditions, such as Helicobacter pylori infection. A certain correlation between hepatitis C virus (HCV) infection and low grade MALT lymphomas has recently been reported. The aim of this study was to investigate the presence of HCV RNA in acquired gastric MALT of HCV-infected patients using the in situ hybridization technique. METHODS: Twenty-five patients (16 male and nine female, average age = 56.6 yr [range = 33-75]) affected by chronic HCV hepatitis and with gastric MALT were studied. Giemsa stain and the rapid ...
Helicobacter Pylori Antigen Test Kit - Stool Test for Stomach Ulcer CE Approved Intended UseLaboquick Helicobacter pylori antigen cassette test is used as a diagnostic tool to detect qualitative immunochromatographic helicobacter pylori antigen (HP Ag) in stool. Helicobacter pylorus is a gram-negative bacterium that c
However in many cases, there is no known trigger, leading to a diagnosis of idiopathic chronic urticarial.. A number of studies have indicated that H pylori infection may play a role in the development of urticaria / hives because of the damage caused to the stomach by the infection.. The inflammatory response in the stomach and small intestine (gastritis & duodenitis, respectively) that is caused by H pylori infection may lead to an increase in permeability of the delicate gut lining.. In other words, tiny gaps and holes appear in the stomach lining, which allow larger, undigested particles of food, bacterial antigens or chemicals into the blood. Once there, the immune system mounts a response, leading to inflammation on the skin.. Several other mechanisms involving the immune system may also contribute to the development of chronic urticaria in H pylori-infected people.. Some studies - I have seen the data from 16 studies in total - have shown partial or complete remission in urticaria in ...
Dr Barry Marshall, Nobel Prize Winner, Scientific Director at Ondek has delivered a presentation showing his latest research on Helicobacter pylori platform technology (HPPT) and its unique potential as an oral delivery system at the World Vaccine Congress last week.. Dr. Marshall described the prospects for a vaccine system using modified Helicobacter pylori which is ingested by drinking and colonizes the stomach and delivers target agents to the host environment. It is called HPPT or Helicobacter pylori platform technology. Housed at University of Western Australia, Ondek has 12 employees who have been working on this technology for the past 5 years, and they work with quite a number of additional collaborators.. H. pylori infection is always associated with histological gastritis, and results in the production of IgG. Even nontoxigenic helicobacter will always give gastritis. Through genetic engineering, wild-type genes causing host symptoms can be removed if desired, and target genes can ...
Aim : To study whether eradication of Helicobacter pylori (H. pylori) in patients with functional dyspepsia affects gastric emptying (GE) and concomitantly relieves their clinical symptoms. Material and methods : Eighteen H. pylori -positive patients suffering from functional dyspepsia...
Helicobacter pylori infection is a high prevalence infection worldwide, and it is more common in developing countries than developed ones (Magalhães and Luzza, 2006). It is a major risk factor for chronic gastritis, peptic ulcer and gastric cancer (Fock and Ang, 2010). The ABO blood group system is the most important in human blood transfusion. The blood group antigens present on RBC are permanent, fixed and lifelong biological markers of any individual, they are almost as individual as fingerprints (Ravn and Dabelstein, 2000). The distribution of the ABO blood groups varies in populations throughout the world (Garratty et al., 2004). In addition to clinical significance for transfusion and transplantation, it is becoming increasingly apparent that ABO antigens are of biological significance and may be associated with predisposition to, or protection from many diseases (Reid and Bird, 1990).. Many authors reported an association between blood group O and H. pylori infection (Kanbay, et al., ...
Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the human stomach and is a major gastric infection worldwide. Approximately over 50% of the adult population in developed countries and 80% in developing countries are infected with this bacterium. H. pylori infection is invariably associated with gastritis, and triggers autoantibodies by a mechanism of molecular mimicry. It may play an important role in the impairment of vitamin B12 absorption leading to pernicious anaemia. This case report highlights H. pylori as a causative agent in vitamin B12 deficiency. H. pylori treatment reverse the underlying pathogenesis and corrects the vitamin B12 deficient state in selected individuals.
AIMS: To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. METHODS: Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). RESULTS: Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. CONCLUSIONS: Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma. ...
Persistent colonization of the human stomach by Helicobacter pylori is associated with asymptomatic gastric inflammation (gastritis) and an increased risk of duodenal ulceration, gastric ulceration, and non-cardia gastric cancer. In previous studies, the genome sequences of H. pylori strains from patients with gastritis or duodenal ulcer disease have been analyzed. In this study, we analyzed the genome sequences of an H. pylori strain (98-10) isolated from a patient with gastric cancer and an H. pylori strain (B128) isolated from a patient with gastric ulcer disease. Based on multilocus sequence typing, strain 98-10 was most closely related to H. pylori strains of East Asian origin and strain B128 was most closely related to strains of European origin. Strain 98-10 contained multiple features characteristic of East Asian strains, including a type s1c vacA allele and a cagA allele encoding an EPIYA-D tyrosine phosphorylation motif. A core genome of 1237 genes was present in all five strains for which
Helicobacter pylori eradication therapy can be used as an initial treatment option for patients with H pylori-negative gastric MALT lymphoma.
There is no current standard rescue treatment for dual drug-resistant strains of Helicobacter pylori (H. pylori). This aim of this study was to investigate the efficacy of rifabutin-based triple therapy for patients infected with dual drug-resistant strains to clarithromycin and levofloxacin. After 2 or 3 H. pylori treatment failures, patients underwent upper endoscopy with tissue biopsies. Phenotypic and genotypic resistances were determined using agar dilution test and polymerase chain reaction with direct sequencing, respectively. Patients infected with dual drug-resistant (clarithromycin and levofloxacin) strains and receiving rifabutin-based triple therapy (rifabutin 150 mg bid, amoxicillin 1 g bid and esomeprazole 40 mg bid for 10 days) were enrolled. Eradication status was determined by 13C-urea breath test 4 weeks after treatment completion. A total of 39 patients infected with dual drug-resistant strains were enrolled in this study, with a mean age of 55.9 years. The eradication rate was 79.5%
The association between proinflammatory cytokine gene polymorphisms and gastric diseases related to Helicobacter pylori varies by population and geographic area. Our objective was to determine if the IL-1B -511 T|C and -31 C|T polymorphisms and H. pylori vacA genotypes are associated with risk of chronic gastritis and gastric ulcer in a Mexican population. We conducted endoscopic studies in 128 patients with symptoms of dyspepsia. We took two biopsies from the body, antrum, or ulcer edge from each patient, and classified our histopathological findings according to the Sydney System. H. pylori infection and vacA genotyping were accomplished via PCR from total DNA of the gastric biopsies. We confirmed the presence of anti-H. pylori serum IgG and IgM in 102 control subjects. In both case subjects and control subjects, the IL-1B -511 T|C polymorphism was genotyped by PCR-RFLPs and the IL-1B -31 C|T polymorphism was genotyped by pyrosequencing. Sixty-two point seven (62.7%) of the 102 control subjects were H
TY - JOUR. T1 - Regulation of RANTES promoter activation in gastric epithelial cells infected with Helicobacter pylori. AU - Kudo, Takahiko. AU - Lu, Hong. AU - Wu, Jeng Yih. AU - Graham, David Y.. AU - Casola, Antonella. AU - Yamaoka, Yoshio. PY - 2005/11. Y1 - 2005/11. N2 - RANTES, a CC chemokine, plays an important role in the inflammatory response associated with Helicobacter pylori infection. However, the mechanism by which H. pylori induces RANTES expression in the gastric mucosa is unknown. We cocultured gastric epithelial cells with wild-type H. pylori, isogenic oipA mutants, cag pathogenicity island. (PAI) mutants, or double knockout mutants. Reverse transcriptase PCR showed that RANTES mRNA was induced by H. pylori and that the expression was both OipA and cag PAI dependent. Luciferase reporter gene assays and electrophoretic mobility shift assays showed that maximal H. pylori-induced RANTES gene transcription required the presence of the interferon-stimulated responsive element ...
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Fundamentos: a rosácea é uma dermatose freqüente que possui multiplicidade de fatores envolvidos no seu desencadeamento. Na literatura recente, há autores que apontam o Helicobacter pylori como um possível agente etiológico da doença. Porém os poucos estudos publicados sobre o assunto que utilizaram pacientes controles não encontraram evidências de que esta associação seja importante. No Brasil, não há trabalhos publicados quanto à exposição ao Helicobacter pylori em pacientes com rosácea, e mesmo o perfil geral dos pacientes com rosácea, no país, é pouco conhecido. Objetivos: o principal objetivo do estudo foi avaliar se a exposição ao Helicobacter pylori constitui um fator de risco para o desenvolvimento da rosácea. Os outros objetivos do trabalho foram: avaliar uma possível diferença da presença de distúrbios dispépticos entre casos de rosácea e controles, analisar se a exposição ao Helicobacter pylori ocorre homogeneamente nos diferentes estágios evolutivos ...
TY - JOUR. T1 - Light microscopic and ultrastructural evidence of in vivo phagocytosis of Helicobacter pylori by neutrophils. AU - Zu, Youli. AU - Cassai, N. D.. AU - Sidhu, G. S.. PY - 2000/1/1. Y1 - 2000/1/1. N2 - Helicobacter pylori is believed to cause chronic active gastritis. Infection/colonization of the gastric mucosal surface induces a mucosal inflammatory reaction in the form of lymphocytic aggregates, plasma cells and, particularly, neutrophils, which may, in turn, damage the mucosal epithelium. In vitro studies demonstrate that, in culture, the bacilli are readily phagocytosed by neutrophils, this evoking a neutrophilic oxidative burst. However, it has been claimed that neutrophils do not phagocytose H. pylori in vivo. In this study of 19 endoscopic biopsies of gastric mucosa with H. pylori-associated gastritis, Cresyl violet staining for light microscopy and electron microscopy are used to demonstrate that, in vivo, neutrophils actively phagocytose and destroy the bacilli in the ...
Helicobacter pylori tests are used to detect a Helicobacter pylori ( H. pylori) infection in the stomach and upper part of the small intestine ( duodenum). H. pylori can cause peptic ulcers. But most people with H. pylori in their digestive systems do not develop ulcers. Four tests are used to detect H. pylori: Blood...
Hellenic Society of Gastroenterology. Annals of Gastroenterology.Journal part.Image.Scientific article.Article.2017 . Creators: Duddempudi, Sushil, Lin, Thinzar, Linn, Sandar, Ona, Mel A.. Types: info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion
Extracts of Helicobacter pylori (HP) have been shown to induce leukocyte adhesion in mesenteric venules, but the effects of HP infection on gastric microvessels are unknown. Inflammatory cell interactions in the gastric microcirculation were studied by intravital videomicroscopy in mice inoculated with either saline or fresh isolates of HP. Platelet aggregates were detected and quantified in murine portal blood, while endothelial P-selectin expression was determined using the dual radiolabeled mAb technique. Platelet activation and aggregation were studied in HP-infected patients and controls by measuring the platelet-aggregate ratio and platelet P-selectin expression. HP infection induced a marked increase in the flux of rolling leukocytes and the appearance of platelet and leukocyte- platelet aggregates in murine gastric venules. The HP-induced rolling and platelet aggregate formation was abrogated by mAbs against L- or P-, but not E- selectin. Endothelial cell expression of P-selectin was not ...
Human stomach is the only known natural habitat of |i|Helicobacter pylori|/i| (|i|Hp|/i|), a major bacterial pathogen that causes different gastroduodenal diseases. Despite this, the impact of |i|Hp|/i| on the diversity and the composition of the gastric microbiota has been poorly studied. In this study, we have analyzed the culturable gastric microbiota of 215 Malaysian patients, including 131 |i|Hp|/i| positive and 84 |i|Hp|/i| negative individuals that were affected by different gastric diseases. Non-|i|Hp|/i| bacteria isolated from biopsy samples were identified by matrix assisted laser desorption ionization-time of flight mass spectrometry based biotyping and |i|16SrRNA|/i| sequencing. The presence of |i|Hp|/i| did not significantly modify the diversity of the gastric microbiota. However, correlation was observed between the isolation of Streptococci and peptic ulcer disease. In addition, as a first report, |i|Burkholderia pseudomallei|/i| was also isolated from the gastric samples of the local
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Prevalence of Helicobacter pylori (H. pylori) differs among populations worldwide. H. pylori has been correlated with gastritis, peptic ulcer and cancer. Considering the treatment failure due to antibiotic resistance, proper treatment of H. pylori infection is of great importance.The aim of this study was to determine the prevalence of H. pylori infection based on age, sex and also to examine antibiotic resistance among patients referred to the endoscopy department of Shahid Beheshti University of Medical Sciences hospitals in Tehran from 2010 to 2011.In this descriptive study, biopsies were taken from 192 patients with dyspepsia who underwent endoscopic evaluation. For diagnosis of H. pylori infection and histologic assessment, samples were stained by Giemsa and hematoxylin-eosin (H & E) staining. Based on the Sydney system for classification of gastritis, extent of H. pylori infection and severity of gastritis were measured. To determine antibiotic resistance after culturing on Brucella agar
"Helicobacter Pylori Infections: MedlinePlus". www.nlm.nih.gov. Retrieved 2016-04-03. "Details: DSM-1740". www.dsmz.de. ... detection of Helicobacter cetorum-like and Candidatus Wolinella africanus-like DNA". Helicobacter. 12 (5): 553-558. doi:10.1111 ... The order Campylobacterales includes human pathogens such as Helicobacter pylori and Campylobacter jejuni. The only publicly ...
Helicobacter pylori bacterial infections; shaken baby syndrome and other forms of child abuse; overlaying, child smothering ... Weber MA, Klein NJ, Hartley JC, Lock PE, Malone M, Sebire NJ (May 2008). "Infection and sudden unexpected death in infancy: a ... SIDS makes up about 80% of sudden and unexpected infant deaths (SUIDs). The other 20% of cases are often caused by infections, ... Stray-Pedersen A, Vege A, Rognum TO (October 2008). "Helicobacter pylori antigen in stool is associated with SIDS and sudden ...
Kusters, Johannes G.; Vliet, Arnoud H. M. van; Kuipers, Ernst J. (2006-07-01). "Pathogenesis of Helicobacter pylori Infection ... cagA and iceA Alleles in Helicobacter pylori in Hong Kong". Helicobacter. 6 (4): 317-324. doi:10.1046/j.1523-5378.2001.00040.x ... Xu, Q.; Peek, R. M.; Miller, G. G.; Blaser, M. J. (1997-11-01). "The Helicobacter pylori genome is modified at CATG by the ... A homolog of NlaIIIR is iceA1 from Helicobacter pylori. In H. pylori, there exists a similar methylase gene called hpyIM which ...
Helicobacter pylori infection. Gluten-related disorders: untreated celiac disease and non-celiac gluten sensitivity. Anemia can ... Causes of increased breakdown include genetic conditions such as sickle cell anemia, infections such as malaria, and certain ... Gyorkos TW, Gilbert NL, Larocque R, Casapía M (April 2011). "Trichuris and hookworm infections associated with anaemia during ... especially at advanced stages Infection by intestinal nematodes feeding on blood, such as hookworms and the whipworm Trichuris ...
Smoking Helicobacter pylori infection. Diet low in fruits and vegetables. Diet high in salt and nitrates. Polyps Genetic ...
Bacterial infection may also increase the risk of cancer, as seen in Helicobacter pylori-induced stomach cancer. Parasitic ... The most prominent example is the link between chronic infection of the wall of the stomach with Helicobacter pylori and ... Wang C, Yuan Y, Hunt RH (August 2007). "The association between Helicobacter pylori infection and early gastric cancer: a meta- ... Dore MP, Pes GM, Bassotti G, Usai-Satta P (2016). "Dyspepsia: When and How to Test for Helicobacter pylori Infection". ...
Dore MP, Pes GM, Bassotti G, Usai-Satta P (2016). "Dyspepsia: When and How to Test for Helicobacter pylori Infection". ... In other examples, UV light from solar radiation causes DNA damage that is important in melanoma, Helicobacter pylori infection ... Meurer LN, Bower DJ (April 2002). "Management of Helicobacter pylori infection". Am Fam Physician. 65 (7): 1327-36. PMID ... Koeppel M, Garcia-Alcalde F, Glowinski F, Schlaermann P, Meyer TF (June 2015). "Helicobacter pylori Infection Causes ...
Helicobacter pylori infection Helicobacter pylori Hemolytic-uremic syndrome (HUS) Escherichia coli O157:H7, O111 and O104:H4 ... Human papillomavirus (HPV) infection One of the Human papillomaviruses Human parainfluenza virus infection Human parainfluenza ... Infections associated with diseases. References[edit]. *^ Walsh TJ, Dixon DM (1996). Baron S, et al., eds. Spectrum of Mycoses ... Acinetobacter infections Acinetobacter baumannii Actinomycosis Actinomyces israelii, Actinomyces gerencseriae and ...
Helicobacter pylori infections also reduce the availability of iron. Inflammation leading to hepcidin-induced restriction on ... "Iron deficiency anaemia and Helicobacter pylori infection". International Journal of Antimicrobial Agents. 16 (4): 515-519. doi ... Although this mechanism is an elegant response to short-term bacterial infection, it can cause problems when it goes on so long ... In response to a systemic bacterial infection, the immune system initiates a process known as iron withholding. If bacteria are ...
"Helicobacter pylori infection and gastric lymphoma". N Engl J Med. 330 (18): 1267-71. doi:10.1056/NEJM199405053301803. PMID ... pylori infection and MALT lymphoma, identification of the infection is imperative. Histological examination of GI biopsies ... As proton-pump inhibition can suppress infection, any treatment with this class of drug should be ceased 2 weeks prior to ... Following the recognition of the association of gastric MALT lymphoma with H. pylori infection, it was established that early- ...
"Helicobacter pylori infection and chronic urticaria". Journal of the American Academy of Dermatology. 34 (4): 685-6. doi: ... Acute viral infection is another common cause of acute urticaria (viral exanthem). Less common causes of hives include friction ... Hives frequently occur following an infection or as a result of an allergic reaction such as to medication, insect bites, or ... In most cases, the cause is unknown, although it may be preceded by a viral infection, antibiotic therapy, or emotional upset. ...
Helicobacter pylori colonizes the stomachs of more than half of the world's population, and the infection continues to play a ... Common causes include infection with Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs (NSAIDs). Less common ... Kandulski A, Selgrad M, Malfertheiner P (August 2008). "Helicobacter pylori infection: a clinical overview". Digestive and ... The immune system makes proteins and antibodies that fight infections in the body to maintain a homeostatic condition. In some ...
Primary gastric EMZL is associated with infection of the stomach with Helicobacter pylori in >80% of cases or with Helicobacter ... One or more of these vaccines may be a promising candidates to control Helicobacter pylori infection in humans as well as farm ... Individuals with chronic Helicobacter pylori infection may also have halitosis. Endoscopic inspection and biopsy of lesions and ... In a 2017 review, 6 of 18 patients with EMZL of the esophagus had evidence of concurrent Helicobacter pylori infection. The ...
May 1994). "Helicobacter pylori infection and gastric lymphoma". N. Engl. J. Med. 330 (18): 1267-71. doi:10.1056/ ... Helicobacter pylori Long-term immunosuppressant drug therapy HIV infection These lymphomas are difficult to differentiate from ...
Factors such as infection with Helicobacter pylori, a rise in thyroid hormone production, low age, low body mass index prior to ... "Endoscopy in hyperemesis gravidarum and Helicobacter pylori infection". International journal of gynaecology and obstetrics: ... Other potential causes of the symptoms should be excluded including urinary tract infection and high thyroid levels. Treatment ...
Use in treating Helicobacter pylori infections has also been proposed. Furazolidone has also been used for giardiasis (due to ... As a veterinary medicine, furazolidone has been used with some success to treat salmonids for Myxobolus cerebralis infections. ... Though an effective antibiotic when all others fail, against extremely drug resistant infections, it has many side effects. ... Machado RS, Silva MR, Viriato A (2008). "Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter ...
ISBN 978-0-7817-5325-8. Northfield, T. C.; Mendall, M.; Goggin, P. M. (2012-12-06). Helicobacter pylori Infection: ... Infection of bulls with Cfv is a chronic, asymptomatic infection that leads to the development carrier bulls in the breeding ... Infection from ingestion of Cff-contaminated placenta is also a possible route of infection. Ewes that appear to be ... Infections and pregnancy loss in subsequent calving seasons is substantially less severe than the first season of infection, as ...
1997). "Helicobacter pylori infection and chronic gastric acid hyposecretion". Gastroenterology. 113 (1): 15-24. doi:10.1016/ ... In 1999, a review of existing studies found that, on average, 40% of GERD patients also had H. pylori infection.[30] The ... Neutrophilic inflammation (usually due to reflux or Helicobacter gastritis). *Eosinophilic inflammation (usually due to reflux ... O'Connor HJ (February 1999). "Helicobacter pylori and gastro-oesophageal reflux disease-clinical implications and management". ...
February 2007). "Gastrokine 1 expression in patients with and without Helicobacter pylori infection". Digestive and Liver ...
"Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice". J. Antimicrob. Chemother. 51 (2): 367-71. ... Bebb JR, Bailey-Flitter N, Ala'Aldeen D, Atherton JC (September 2003). "Mastic gum has no effect on Helicobacter pylori load in ... Another 1998 University of Nottingham study, claims that mastic can heal peptic ulcers by killing Helicobacter pylori, which ... February 2007). "In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori". ...
"Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells". Infection ... Stomach cancer is the fourth most common cancer [990,000 cases (7.8%), 738,000 deaths (9.7%)]. Helicobacter pylori infection is ... Infection of gastric epithelial cells with H. pylori results in increased production of reactive oxygen species (ROS). ROS ... Other infectious organisms which cause cancer in humans include some bacteria (e.g. Helicobacter pylori ) and helminths (e.g. ...
Graham DY, Shiotani A (June 2008). "New concepts of resistance in the treatment of Helicobacter pylori infections". Nat. Clin. ... the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori ...
Helicobacter pylori infection Coeliac disease Bacterial infection Viral infection NSAIDs Autoimmune diseases (i.e. Crohn's ... Treatment is aimed at removing the irritant or infection. Helicobacter pylori infection is usually treated with antibiotics. ...
It is effective as one part of a multi-drug regimen for treatment of stomach infections of Helicobacter pylori. It is typically ... skin infections, urinary tract infections, Salmonella infections, Lyme disease, and chlamydia infections. Children with acute ... These include middle ear infection, strep throat, pneumonia, skin infections, and urinary tract infections among others. It is ... Chey WD, Leontiadis GI, Howden CW, Moss SF (February 2017). "ACG Clinical Guideline: Treatment of Helicobacter pylori Infection ...
examined Helicobacter rodentium infection and the resulting ulcerative typhlocolitis, sepsis, and morbidity. Using ASF mice, ... and Helicobacter hepaticus infection in the intestines of Swiss Webster mice. 2006. Appl. Environ, Microbiol. 72(7):5100.] [ ... Even in SPF mice, there are many Helicobacter and Filamentous species not included in ASF1. Not to mention the many bacteria ... 74(12):6615.] [Fox, J. G. Helicobacter bilis: bacterial provocateur orchestrates host immune responses to commensal flora in a ...
Carcinoma Helicobacter pylori infection Causes inflammation of the folds. Gastric syphilis Cytomegalovirus Mucosa change shape ...
1997). "Helicobacter pylori infection and chronic gastric acid hyposecretion". Gastroenterology. 113 (1): 15-24. doi:10.1016/ ... O'Connor HJ (February 1999). "Helicobacter pylori and gastro-oesophageal reflux disease-clinical implications and management". ... pylori infection. The eradication of H. pylori can lead to an increase in acid secretion, leading to the question of whether H ... usually due to reflux or Helicobacter gastritis) Eosinophilic inflammation (usually due to reflux): The presence of ...
Uncomplicated Helicobacter pylori infection does not cause chronic nausea. Food poisoning usually causes an abrupt onset of ... obstruction Colonic obstruction Superior mesenteric artery syndrome Enteric infections Viral infection Bacterial infection ... Gastrointestinal infection is one of the most common causes of acute nausea and vomiting. Chronic nausea may be the ... If the patient's symptoms have an acute onset, then drugs, toxins, and infections are likely. In contrast, a long-standing ...
... associated with Helicobacter pylori infection may respond to H. pylori eradication therapy, although resumption of ... 1997). "Helicobacter pylori infection and chronic gastric acid hyposecretion". Gastroenterology. 113 (1): 15-24. doi:10.1016/ ... A symptom of Helicobacter pylori infection which neutralizes and decreases secretion of gastric acid to aid its survival in the ... Risk of particular infections, such as Vibrio vulnificus (commonly from seafood) is increased. Even without bacterial ...
The mainstay of treatment for SSSS is supportive care along with eradication of the primary infection. Conservative measures ...
Yersin looked for the germ responsible for the infection specifically in these plague-spots, tumors caused by the inflammation ... produced a genetically engineered vaccine against hepatitis B and a rapid diagnostic test for the detection of the Helicobacter ... The discovery and use of sulfonamides in treating infections was another breakthrough. Some researchers won fame by discovering ... mistake by the Institute was ignoring a dissertation by Ernest Duchesne on the use of Penicillium glaucum to cure infections in ...
Helicobacter pylori *Peptic ulcer, MALT lymphoma, Gastric cancer. *Helicobacter cinaedi *Helicobacter cellulitis ... Kidney infection, if it occurs, usually follows a bladder infection but may also result from a blood-borne infection.[12] ... A urinary tract infection (UTI) is an infection that affects part of the urinary tract.[1] When it affects the lower urinary ... Urinary tract infections are the most frequent bacterial infection in women.[17] They occur most frequently between the ages of ...
Infection with the bacteria Helicobacter bilis and Helicobacter hepaticus species can cause biliary cancer.[27] ... Such laboratory findings suggest obstruction of the bile ducts, rather than inflammation or infection of the liver parenchyma, ... Primary sclerosing cholangitis, ulcerative colitis, infection with certain liver flukes, some congenital liver malformations[1] ... infection with certain liver fluke, and some congenital liver malformations.[1][3][8] However, most people have no identifiable ...
Do common childhood infections 'teach' the immune system not to be allergic?»։ Immunology Today 21 (3): 118-20։ March 2000։ ... և Helicobacter pylori ) հետ շփումը կարող է նվազեցնել ատոպիաների զարգացման ռիսկը 60%-ով[117] և մակաբույծների հանդիպման ... "AAAAI - rhinitis, sinusitis, hay fever, stuffy nose, watery eyes, sinus infection". Archived from the original on 16 November ...
Bacterial infection is the most common cause.[8] Often many different types of bacteria are involved in a single infection.[6] ... They are usually caused by a bacterial infection.[8] Often many different types of bacteria are involved in a single infection. ... Marx, John A. Marx (2014). "Skin and Soft Tissue Infections". Rosen's emergency medicine : concepts and clinical practice (8th ... Abscesses are caused by bacterial infection, parasites, or foreign substances. ...
However, it is more likely that diversification is driven by evasion of pathogen infection mechanism (e.g. Helicobacter ...
Helicobacter pylori[edit]. Some strains of lactic acid bacteria (LAB) may affect Helicobacter pylori infections (which may ... Hamilton-Miller JM (October 2003). "The role of probiotics in the treatment and prevention of Helicobacter pylori infection". ... Immune function and infections[edit]. Some strains of LAB may affect pathogens by means of competitive inhibition (i.e., by ... Shortliffe LMD (2013). Wein AJ (ed.). Chapter 116: Infection and Inflammation of the Pediatric Genitourinary Tract. Urology. 4 ...
... inflammation and bacterial infection in the respiratory tract. Lactoferrin with hypothiocyanite has been granted orphan drug ... Helicobacter Pylori • Klebsiella oxytoca • Klebsiella pneumoniae • Legionella • Listeria monocytogenes • Micrococcus luteus • ... "Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice". J. Med. Microbiol ... weakened respiratory immune system against bacterial infection. Symptoms of cystic fibrosis include an inability to secrete ...
... of people with gonorrheal infection also have chlamydial infection.[54] Infections of the throat can be especially problematic ... Helicobacter pylori *Peptic ulcer, MALT lymphoma, Gastric cancer. *Helicobacter cinaedi *Helicobacter cellulitis ... Both men and women with infections of the throat may experience a sore throat, though such infection does not produce symptoms ... The infection is usually spread from one person to another through vaginal, oral, or anal sex.[15][22] Men have a 20% risk of ...
... is an infection of the small intestine by some strains of the bacterium Vibrio cholerae.[4][3] Symptoms may range from ... Helicobacter pylori *Peptic ulcer, MALT lymphoma, Gastric cancer. *Helicobacter cinaedi *Helicobacter cellulitis ... "The Journal of Infection. 66 (5): 432-8. doi:10.1016/j.jinf.2012.11.013. PMC 3677557. PMID 23201968.. ... Infection with V. cholerae O139 should be reported and handled in the same manner as that caused by V. cholerae O1. The ...
If the infection is severe, the doctor may prescribe antibiotics, such as ciprofloxacin or TMP-SMX (Bactrim). Unfortunately, ... "Enterobacteriaceae, Vibrio, Campylobacter and Helicobacter". Archived from the original on 24 December 2008. Retrieved 2008-12- ... In addition, chronic arthritis secondary to S. flexneri infection, called reactive arthritis, may be caused by a bacterial ... Bacillary dysentery should not be confused with diarrhea caused by other bacterial infections. One characteristic of bacillary ...
"Comparison of Diagnostic Techniques for Helicobacter cetorum Infection in Wild Atlantic Bottlenose Dolphins (Tursiops truncatus ... An analysis of feces of two dolphin and one whale species led to the discovery of a new species of Helicobacter, namely ... Helicobacter cetorum, the bacteria being associated with clinical symptoms and gastritis in the cetaceans.[15] ...
The presence of a carbuncle is a sign that the immune system is active and fighting the infection.[2] The infection is ... persons with diabetes and immune system diseases are more likely to develop infections (especially bacterial infections of the ... A carbuncle is a cluster of boils caused by bacterial infection, most commonly with Staphylococcus aureus or Streptococcus ... Ni Riain, Una (2008-12-01). "Guide to the management of bacterial skin infections". Prescriber. 19 (23-24): 28-37. doi:10.1002/ ...
González CA, Sala N, Rokkas T (2013). "Gastric cancer: epidemiologic aspects". Helicobacter. 18 (Supplement 1): 34-38. doi: ... Also rather important are the viral infections to which some of these ectoparasites serve as vectors such as the aphid- ...
Hatakeyama M, Higashi H (December 2005). "Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis". Cancer ... and the activity of the system is thought to functionally resemble phage infection.[25] ... Helicobacter pylori uses a type IV secretion system to deliver CagA into gastric epithelial cells, which is associated with ...
Infection and Immunity. . 20, Nr. 2, Mai 1978, S. 456-63. PMID 352945. PMC 421877 (freier Volltext). ... Sensitivity of Helicobacter pylori to an innate defence mechanism, the lactoperoxidase system, in buffer and in human whole ... darunter auch mikroaerophile Helicobacter pylori.[19] Der Effekt des Lactoperoxidase-Systems hängt von bestimmten ...
Untreated, median survival is only 2.5 months, sometimes due to concurrent opportunistic infections rather than the lymphoma ... infection (, 90%) in immunodeficient patients (such as those with AIDS and those immunosuppressed),[2] and does not have a ... of all cases of lymphomas in HIV infections (other types are Burkitt's lymphomas and immunoblastic lymphomas). Primary CNS ... in a subgroup of AIDS patients with CD4 counts of more than 200 and no concurrent opportunistic infections, who can tolerate ...
The symptoms of Campylobacter infections were described in 1886 in infants by Theodor Escherich.[10] These infections were ... Samie, A.; Obi, C.L.; Barrett, L.J.; Powell, S.M.; Guerrant, R.L. (2007). "Prevalence of Campylobacter species, Helicobacter ... "Infection and Immunity. 61 (5): 1764-71. PMC 280763. PMID 8478066.. *^ Firehammer, BD; Border, M (1968). "Isolation of ... "Campylobacter Infections: Background, Pathophysiology, Epidemiology".. *^ a b Ryan, Kenneth James; Ray, C. George, eds. (2004 ...
"AstraZeneca To Acquire Infection Research Company Novexel And Expand Collaboration With Forest Laboratories". 23 December 2009 ... treatment of duodenal ulcers caused by Helicobacter pylori, prevention of gastric ulcers in those on chronic NSAID therapy, and ...
... and infection (such as sepsis, pneumonia, urinary tract infection) was reported in patients receiving ranitidine in a cohort ... Part of a multidrug regimen for Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence ... 2012). "Ranitidine Is Associated With Infections, Necrotizing Enterocolitis, and Fatal Outcome in Newborns". Pediatrics. 129 (1 ... "Recent treatment with H2-antagonists and antibiotics and gastric surgery as risk factors for Salmonella infection". Br Med J ...
In the initial variant of the urea breath test, a diagnostic test for Helicobacter pylori, urea labeled with approximately 37 ... kBq (1.0 μCi) carbon-14 is fed to a patient (i.e., 37,000 decays per second). In the event of a H. pylori infection, the ...
"Helicobacter pylori infection and chronic urticaria". Journal of the American Academy of Dermatology. 34 (4): 685-6. doi: ... InfectionsEdit. Hive-like rashes commonly accompany viral illnesses, such as the common cold. They usually appear three to five ... Infection or environmental agentEdit. Hives including chronic spontaneous hives can be a complication and symptom of a ... Acute viral infection is another common cause of acute urticaria (viral exanthem). Less common causes of hives include friction ...
Campylobacter jejuni (Campylobacteriosis, Guillain-Barré syndrome) · Helicobacter pylori (Peptic ulcer, MALT lymphoma) · ... Rickettsia aeschlimannii infection) ...
2005 - Barry Marshall and Robin Warren, Australia, for finding the bacterium Helicobacter pylori that causes gastritis and ... 1926 - Johannes Andreas Grib Fibiger, Denmark, for his discovery that an infection could lead to cancer[20] ...
... of cancers are due to infections such as Helicobacter pylori, hepatitis B, hepatitis C, human papillomavirus infection, Epstein ... Bacterial infection may also increase the risk of cancer, as seen in Helicobacter pylori-induced gastric carcinoma.[48][49] ... Journal of Infection in Developing Countries. 4 (5): 267-81. doi:10.3855/jidc.819. PMID 20539059. Archived from the original on ... Infection. Main article: Infectious causes of cancer. Worldwide approximately 18% of cancer deaths are related to infectious ...
Treatment of a Helicobacter pylori infection can be completed by taking a triple therapy combination of omeprazole, amoxicillin ... "Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report". Gut. 56 (6): 772-81 ... Respiratory: upper respiratory tract infection (2%), cough (1%). *Gastrointestinal: abdominal pain (5%), diarrhea (4%), nausea ... Duration of First-Line Proton-Pump Inhibitor-Based Triple Therapy for Helicobacter pylori Eradication". Annals of Internal ...
The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by ... Helicobacter (gram -) Hemophilus (gram -) Klebsiella (gram -) Legionella (gram -) Leptospiria (gram -) Neisseria (gram -) ...
... and Th17 to fight for instance gastric Helicobacter pylori infection when a vaccine is given. In addition to some of these AB5 ... Contaminated food and drinks are the source of infection and how this toxin is spread. Symptoms include abdominal pain as well ... of Escherichia coli heat-labile toxin and its B subunit for immunization of mice against gastric Helicobacter pylori infection ... PDI) Thorpe, C. M. (1 May 2004). "Shiga Toxin--Producing Escherichia coli Infection". Clinical Infectious Diseases. 38 (9): ...
"Relation of smoking and alcohol and coffee consumption to active Helicobacter pylori infection: cross sectional study". BMJ 315 ...
H pylori infection is the most common cause of peptic ... Helicobacter pylori (H pylori) is a type of bacteria that ... Helicobacter pylori infection. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtrans Gastrointestinal and Liver ... H pylori infection is the most common cause of peptic ulcers. However, the infection does not cause problems for most people. ... Helicobacter pylori and other gastric Helicobacter species In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and ...
Article: Early genetic diagnosis of clarithromycin resistance in Helicobacter pylori. * Helicobacter Pylori Infections -- see ... Helicobacter Pylori Infections (American Academy of Pediatrics) Also in Spanish * Stool Test: H. Pylori Antigen (Nemours ... Helicobacter pylori (H. pylori) is a type of bacteria that causes infection in the stomach. It is the main cause of peptic ... The primary NIH organization for research on Helicobacter Pylori Infections is the National Institute of Diabetes and Digestive ...
The epidemiology of Helicobacter pylori infection.. Taylor DN1, Blaser MJ.. Author information. 1. Department of Enteric ... The known features of H. pylori infection are listed in. Infection is chronic and common throughout the world, with a higher ... Acquisition of H. pylori infection does not appear to have any seasonality, and infection is equally common among men and women ... pylori infection. Finally, the long term neoplastic consequences of infection must be understood. Further elucidation of the ...
... pylori Infection? Can H. pylori Infection Be Prevented? Source for information on Helicobacter Pylori Infection (Peptic Ulcer ... pylori Infection? How Common Is H. pylori Infection? Is the Infection Contagious? What Are the Signs and Symptoms of H. pylori ... Infection? How Do Doctors Make the Diagnosis? How Is H. pylori Infection Treated? Are There Complications of H. ... Helicobacter Pylori Infection (Peptic Ulcer Disease) What Is H. ... Helicobacter pylori (HEEL-ih-ko-bak-ter pie-LOR-eye) infection ...
How should Helicobacter pylori infection be diagnosed?. Mégraud F1.. Author information. 1. Laboratoire de Bactériologie, ... The ideal approach for the initial diagnosis of Helicobacter pylori infection is to perform an endoscopy to obtain biopsy ... In the event of a doubtful result, an immunoblot can be performed, as is the case for other infections. Patient follow-up after ... Helicobacter Infections/diagnosis*. *Helicobacter Infections/microbiology. *Helicobacter Infections/therapy. *Helicobacter ...
After 30 years of experience in ,i,H. pylori,/i, treatment, however, the ideal regimen to treat this infection has still to be ... infection is the main cause of gastritis, gastroduodenal ulcer disease, and gastric cancer. ... B. J. Egan, L. Marzio, H. OConnor, and C. OMorain, "Treatment of Helicobacter pylori infection," Helicobacter, vol. 13, no. 1 ... A. OConnor, J. P. Gisbert, D. McNamara, and C. OMorain, "Treatment of Helicobacter pylori Infection 2010," Helicobacter, vol ...
... is a gram-negative bacillus responsible for one of the most common infections found in humans worldwide. Warren and Marshall ... encoded search term (Pediatric Helicobacter Pylori Infection) and Pediatric Helicobacter Pylori Infection What to Read Next on ... Exposure to Helicobacter pylori-positive siblings and persistence of Helicobacter pylori infection in early childhood. J ... Kalach N, Bontems P, Raymond J. Helicobacter pylori infection in children. Helicobacter. 2017 Sep. 22 Suppl 1:[Medline]. ...
Chronic infection with H pylori causes atrophic and even metaplastic changes in the stomach, and it has a known association ... Helicobacter pylori (see the image below) is a ubiquitous organism that is present in about 50% of the global population. ... encoded search term (Helicobacter Pylori Infection) and Helicobacter Pylori Infection What to Read Next on Medscape ... Helicobacter Pylori Infection Treatment & Management. Updated: Oct 10, 2019 * Author: Luigi Santacroce, MD; Chief Editor: BS ...
Helicobacter Infection and Spontaneous Bacterial Peritonitis Maria P. Dore, Michele Casu, Giuseppe Realdi, Andrea Piana, Ida ... Helicobacter cetorum sp. nov., a Urease-Positive Helicobacter Species Isolated from Dolphins and Whales C. G. Harper, Y. Feng, ... Role of Corpus Gastritis and cagA-Positive Helicobacter pylori Infection in Reflux Esophagitis Dulciene Maria Magalhães Queiroz ... Prevalence of Helicobacter pylori in Sri Lanka as Determined by PCR N. Fernando, J. Holton, D. Vaira, M. DeSilva, D. Fernando ...
Helicobacter pylori infection is still one of the most common infections worldwide. A significant relationship was reported ... Helicobacter pylori infection is the most common bacterial infection worldwide, especially in the developing countries; its ... Effect of Helicobacter pylori Infection on Serum Lipid Profile. Mohamadreza Haeri,1 Mahmoud Parham,2 Neda Habibi,3 and Jamshid ... "Association of Helicobacter pylori infection with coronary artery disease: is Helicobacter pylori a risk factor?" The ...
Stool antigen test for the diagnosis of Helicobacter pylori infection: A systematic review. Helicobacter. 2004;9(4):347-368. ... Diagnosis of Helicobacter pylori infection. When to use which test and why. Scand J Gastroenterol Suppl. 1996;215:63-65. ... Does Helicobacter pylori infection increase incidence of dementia? The Personnes Agées QUID Study. J Am Geriatr Soc. 2013;61(1 ... Tests for Helicobacter pylori infection: A critical appraisal from primary care. Family Practice. 2000;17(suppl 2):S12-S20. ...
The Report Helicobacter pylori Infections Global Clinical Trials Review, H2, 2016 provides information on pricing, market ... Global Overview of Helicobacter pylori Infections Clinical Trials Review, H2, 2016 "The Report Helicobacter pylori Infections ... Helicobacter pylori Infections Global Clinical Trials Review, H2, 2016" provides an overview of Helicobacter pylori Infections ... medical sciencepharmaceuticalsmarket research reportsequipmentchemicalshelicobacterpylori infectionhelicobacter pylori ...
... infection - Comprehensive overview covers symptoms, treatment of infection with Helicobacter pylori bacteria. ... For H. pylori infection, some basic questions to ask your doctor include: *How did H. pylori infection cause the complications ... Bethesda, Md.: American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Bethesda, Md ... American College of Gastroenterology guideline on the management of Helicobacter pylori infection. ...
A research project to investigate the joint effects of Helicobacter pylori infection, dietary history and genetic polymorphisms ... Helicobacter pylori infection & risk of gastric cancer Investigators. Forman D*, Turner F*, Barrett J*, Giles G, English D, ... To investigate the joint effects of Helicobacter pylori infection, dietary history and genetic polymorphisms in the aetiology ... Immunoblotting using multiple antigens is essential to demonstrate the true risk of Helicobacter pylori infection for gastric ...
Helicobacter pylori is the cause of most peptic ulcer disease and a primary risk factor for gastric cancer. Eradication of the ... Canadian Helicobacter Study Group Consensus Conference on the Approach to Helicobacter pylori Infection in Children and ... Treatment of Helicobacter pylori infection: a review of the world literature. Helicobacter. 1996;1:6-19. ... Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med. 1989;321:1562-6. ...
Helicobacter pylori infection in gastric carcinoma. Download Prime PubMed App to iPhone, iPad, or Android ... AdenocarcinomaAntibodies, BacterialEnzyme-Linked Immunosorbent AssayGastroscopyHelicobacter InfectionsHelicobacter pyloriHumans ... Helicobacter pylori, pepsinogen, and risk for gastric adenocarcinoma.. *Relationship between Helicobacter pylori infection, ... Helicobacter Pylori Infection in Gastric Carcinoma. Eur J Gastroenterol Hepatol. 1994;6 Suppl 1:S93-6. PubMed PMID: 7735944. ...
... Supervisors. G.N.J. Tytgat. Award date. 28 January 2000. Number of pages. ... 07 PPI triple therapy failure in Helicobacter pylori infections: retreatment with PPI triple therapy or quadruple therapy?. ... 04 Helicobacter pylori eradication therapy in The Netherlands. * 05 Efficacy of proton pump inhibitor-based triple therapy in ... 03 A systematic review of Helicobacter pylori eradication therapy; the impact of antimicrobial resistance on eradication rates. ...
Indications for treatment of Helicobacter pylori infection: a systematic overview Message Subject (Your Name) has sent you a ... Indications for treatment of Helicobacter pylori infection: a systematic overview. S. J. Veldhuyzen van Zanten and P. M. ... There is no current evidence to support such therapy for nonulcer dyspepsia in patients with H. pylori infection. Much more ... For the studies of nonulcer dyspepsia with H. pylori infection the authors assessed H. pylori eradication, the symptoms used as ...
Meeting of the European Helicobacter pylori Study Group and European Study Group on Immunology in Helicobacter Infections Dear ... Meeting on Pathogenesis & Host Response in Helicobacter pylori Infections. Ronan OKennedy Ronan.okennedy at ucg.ie Fri Aug 9 ... Second European Meeting on Pathogenesis and Host Response in Helicobacter pylori Infections. University College Galway, Ireland ... we invite you to participate in the Second European Meeting on Pathogenesis and Host Response in Helicobacter pylori Infections ...
... the Helicobacter bacteria are benign inhabitants of the intestinal tract, being found in several species, including domestic ... Gastric Helicobacter felis, Helicobacter heilmannii, Helicobacter rappini, and Helicobater salomonis infection. The method by ... Helicobacter Infection in Dogs. Under normal conditions, the Helicobacter bacteria are benign inhabitants of the intestinal ... The most common forms of Helicobacter found in dogs are Helicobacter felis and Helicobacter heilmannii. Other species of ...
Infection from this bacteria is difficult to eradicate entirely and may last from months to years - even for a lifetime, in ... Learn more about the causes and treatment of this infection in cats on PetMD.com. ... The Helicobacter bacteria are normal inhabitants of the intestinal tract found in several species, including domestic animals, ... Gastric Helicobacter felis, Helicobacter heilmannii, and rarely, Helicobacter pylori infection. The method by which this ...
... pylori infection. Find out if H. pylori infection is contagious. ... infection symptoms include abdominal pain, loss of appetite, ... H. pylori Infection (Helicobacter Pylori): Helicobacter pylori (H. pylori) are bacteria that cause widespread infection. H. ... However, H. pylori infection may cause no symptoms at all. H. pylori infection may be caused by unsanitary conditions, and is ... Amoxicillin is a penicillin antibiotic that is used to treat many different types of infection caused by bacteria, such as ...
Reviews and ratings for amoxicillin/clarithromycin/lansoprazole when used in the treatment of helicobacter pylori infection. 95 ... User Reviews for Amoxicillin / clarithromycin / lansoprazole to treat Helicobacter Pylori Infection. Also known as: Prevpac ... What next? Compare all 49 medications used in the treatment of Helicobacter Pylori Infection. ... Some foods can be intolerable to a body after this infection and can be too hard to deal with. Give it a few days or a week of ...
... infection may contribute to many extragastric diseases including liver cirrhosis and hepatocellular carcinoma. However, the ... Helicobacter infection induces podosome assembly in primary hepatocytes in vitro Eur J Cell Biol. 2012 Mar;91(3):161-70. doi: ... Helicobacter pylori (H. pylori) infection may contribute to many extragastric diseases including liver cirrhosis and ... Infection with the pathogen H. pylori further stimulates the formation of podosomes in primary hepatocytes. The use of ...
... pylori infection. Therefore, H. pylori infection may be an inhibitory f … ... pylori infection and atrophic gastritis, and it may also tend to occur in patients with milder gastritis even in the presence ... Helicobacter pylori infection inhibits reflux esophagitis by inducing atrophic gastritis Am J Gastroenterol. 1999 Dec;94(12): ... Objective: Although it is widely accepted that Helicobacter pylori (H. pylori) infection is an important cause of atrophic ...
... infection among patients at a tertiary healthcare center in Lebanon. ... Background To examine the association between dietary habits and Helicobacter pylori ( H. pylori) ... Helicobacter pylori (H. pylori) infection is one of the most prevalent chronic gastric infections, affecting more than 50% of ... Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of Helicobacter pylori infection. Helicobacter. 2014:19: 1-5. 25167938Google ...
Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes. Christie Y. Jeon, Mary N. Haan, Caroline Cheng ... Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes. Christie Y. Jeon, Mary N. Haan, Caroline Cheng ... Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes Message Subject (Your Name) has forwarded a page ... CONCLUSIONS We demonstrated for the first time that H. pylori infection leads to an increased rate of incident diabetes in a ...
Infection. Helicobacter Infections. Gram-Negative Bacterial Infections. Bacterial Infections. Amoxicillin. Proton Pump ... Intraluminal Clarithromycin Powder Monotherapy for Helicobacter Pylori Infection. The safety and scientific validity of this ... Helicobacter pylori (H. pylori) is the most common chronic bacterial infection in humans. The prevalence of H. pylori is about ... aim to evaluate the efficacy of Clarithromycin powder in the Intraluminal therapy for Helicobacter pylori infection while an ...
Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes. Christie Y. Jeon, Mary N. Haan, Caroline Cheng ... Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes. Christie Y. Jeon, Mary N. Haan, Caroline Cheng ... Helicobacter pylori infection in Chinese subjects with type 2 diabetes. Endocr Res 2001;27:171-177pmid:11428708. ... Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes Message Subject (Your Name) has forwarded a page ...
... as an indicator of the presence and activity of an intragastrointestinal Helicobacter Pylori (HP) infection. Ambulatory ... This system and method may be used in the evaluation of treatments for HP infection in the patient. ... More specifically, this data is used as an indicator of the presence of a Helicobacter Pylori ("HP") infection in the stomach ... 1. A method for monitoring ammonium and for diagnosing the effect of a treatment for helicobacter pylori infection comprising ...
  • The prevalence of H. pylori infection increases with age in parallel with that of gastritis. (nih.gov)
  • H. pylori infection also can cause gastritis (gah-STRY-tis), or inflammation of the lining of the stomach, in adults and children. (encyclopedia.com)
  • Helicobacter pylori infection is the main cause of gastritis, gastroduodenal ulcer disease, and gastric cancer. (hindawi.com)
  • Aetna considers testing of H. pylori infection for the management of autoimmune gastritis experimental and investigational because of insufficient evidence of its effectiveness. (aetna.com)
  • While gastric infection due to Helicobacter pylori is a major health problem in humans - it has been associated with gastritis , gastric tumor, and peptic ulcer in affected people - the significance of the Helicobacter bacterium in dogs and any correlation to gastric dysfunctions is still largely unclear ( H. pylori specifically is not found in dogs). (petmd.com)
  • Although it is widely accepted that Helicobacter pylori (H. pylori) infection is an important cause of atrophic gastritis, few studies have examined the relationship between H. pylori-induced atrophic gastritis and the occurrence of reflux esophagitis. (nih.gov)
  • The present study was aimed to examine the relationship between H. pylori infection, atrophic gastritis, and reflux esophagitis in Japan. (nih.gov)
  • These findings suggest that most cases of reflux esophagitis in Japan occur in the absence of H. pylori infection and atrophic gastritis, and it may also tend to occur in patients with milder gastritis even in the presence of H. pylori infection. (nih.gov)
  • Therefore, H. pylori infection may be an inhibitory factor of reflux esophagitis through inducing atrophic gastritis and concomitant hypoacidity. (nih.gov)
  • H. pylori infection can irritate your stomach, causing inflammation (gastritis). (sparrow.org)
  • The infection can irritate your stomach, causing inflammation (gastritis). (randox.com)
  • IgG subclass response to Helicobacter pylori in patients with chronic active gastritis and duodenal ulcer. (springer.com)
  • Helicobacter pylori infection is marked by a vast prevalence and strong association with various gastric diseases, including gastritis, peptic ulcers, and gastric cancer. (pnas.org)
  • Helicobacter pylori is a common bacterium that can cause gastritis and stomach cancer. (healthcanal.com)
  • The human pathogen Helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. (sciencemag.org)
  • 1 2 3 4 Helicobacter pylori has been linked to different forms of gastritis, peptic ulcer disease, low-grade gastric lymphoma arising from mucosa-associated lymphoid tissue, and gastric adenocarcinoma. (hkmj.org)
  • Helicobacter pylori (H. pylori) is a human-specific gastric pathogen which is responsible for a spectrum of diseases ranging from superficial gastritis to gastric and duodenal ulceration, and which is also highly associated with gastric cancer. (diva-portal.org)
  • Although H pylori infections in people have been linked to gastritis, peptic ulcers, and a higher rate of gastric neoplasia, similar direct casual relationships between Helicobacter infections and GI disease have not been established in dogs and cats. (merckvetmanual.com)
  • In people, H pylori infection is associated with gastritis, peptic ulcers, and an increased risk of gastric neoplasia. (merckvetmanual.com)
  • Gastritis, vomiting, and diarrhea have been associated with Helicobacter infection, although a direct causal relationship has not been identified. (merckvetmanual.com)
  • Currently, the role of Helicobacter as a causative agent of gastritis in dogs and cats is unclear. (merckvetmanual.com)
  • Helicobacter pylori is a causative pathogen of chronic gastritis, gastric ulcer disease, and gastric cancer. (frontiersin.org)
  • Several bacterial infections are now suspected to play a role in the development of cancer but for none is the link so conclusively proven as for H. pylori, which can induce chronic gastritis and ulcer disease, and ultimately lead to the development of cancer. (healthcanal.com)
  • Helicobacter pylori, which has been associated with gastritis and duodenal ulcers, commonly chronically infects adults. (asm.org)
  • H. pylori infection first causes chronic non atrophic gastritis. (scielo.br)
  • BACKGROUND: To assess the relationships among gastric pH and ammonia level, H. pylori infection, and gastric mucosal histology, we determined the gastric juice pH and ammonia concentration in H. pylori gastritis. (biomedsearch.com)
  • CONCLUSION: Gastric juice pH and ammonia concentration reflect well the status of a H. pylori infection, and significantly correlate with each other and with H. pylori density, gastritis severity and activity. (biomedsearch.com)
  • CEACAMs do not occur in healthy stomach tissue, but primarily when there is an inflammation of the gastric mucosa (gastritis) caused by Helicobacter pylori infection. (infectioncontroltoday.com)
  • Helicobacter pylori is a common gastric pathogen that causes gastritis, peptic ulcer disease, gastric adenocarcinoma, and low-grade gastric lymphoma. (merckmanuals.com)
  • H. pylori infection can lead to gastritis and peptic ulcer disease . (merckmanuals.com)
  • Despite an intensive pro-inflammatory response, the immune system is unable to clear the organism in Helicobacter pylori gastritis. (ovid.com)
  • H. pylori eradication heals gastritis and may prevent the spread of infection, reducing the future costs required for the treatment of subsequent H. pylori-associated diseases. (eurekaselect.com)
  • It occurs when a type of bacteria called Helicobacter pylori infects your stomach. (randox.com)
  • Infection with the pathogen H. pylori further stimulates the formation of podosomes in primary hepatocytes. (nih.gov)
  • In fact, studies suggest that pathogen burden, including infectious agents, such as cytomegalovirus, herpes simplex virus (HSV), Chlamydia pneumoniae , and Helicobacter pylori , may have an impact on cardiovascular conditions and metabolic syndrome ( 5 - 7 ) potentially mediated by elevations in inflammatory markers such as C-reactive protein (CRP) and interleukin (IL)-6 ( 5 ). (diabetesjournals.org)
  • Failure to isolate Helicobacter pylori from stray cats indicates that H. pylori in cats may be an anthroponosis--an animal infection with a human pathogen. (canarydatabase.org)
  • While it has been widely accepted that this pathogen plays a role in the development of gastric cancer, these results represent an approach that can reveal a causality between a particular bacterial infection and the development of cancer in humans. (healthcanal.com)
  • The major contributing factor to the development of gastric cancer is colonization and chronic infection by the bacterial pathogen, Helicobacter pylori . (frontiersin.org)
  • The identification of Helicobacter pylori as a pathogen associated with gastric disease has led to serological assays that can establish exposure in larger study populations and hence exploration of associations with diseases epidemiologically. (bmj.com)
  • Helicobacter pylori (HEEL-ih-ko-bak-ter pie-LOR-eye) infection, the major cause of peptic ulcer disease, is a bacterial infection that can lead to inflammation and ulcers* in the lining of the stomach and the upper part of the small intestine* . (encyclopedia.com)
  • In dogs, Helicobacter has been tied to chronic inflammation of the lining of the stomach. (pethealthnetwork.com)
  • However, studies have shown that untreated infections can result in significant inflammation. (pethealthnetwork.com)
  • Our study shows that the interaction between the type of infectious strain and the Th1 immune response can influence and perpetuate gastric inflammation, and thus contributes to the development of the different clinical manifestations of H. pylori infection. (scielo.br)
  • 7 Helicobacter pylori infection is associated with mucosal inflammation due to infiltration by neutrophils and monocytes in the gastric mucosa. (hkmj.org)
  • This method not only detects the infection but also assesses the degree of inflammation and checks for cancer. (marvistavet.com)
  • The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection. (diva-portal.org)
  • These molecules have important roles in the establishment of persistent infection and chronic inflammation, which cause tissue damage. (diva-portal.org)
  • Mucosal inflammation, glandular degeneration, and lymphoid follicle hyperplasia accompany some infections. (merckvetmanual.com)
  • Helicobacter pylori infection is a bacterial infection that causes inflammation of your stomach lining and ulcers (sores) in your stomach or intestine. (merckmanuals.com)
  • In 1982 Barry Marshall and Robin Warren successfully cultured and isolated this spiral bacterium and named it Campylobacter pylori later named as Helicobacter pylori.1 Self-ingestion experiments also demonstrated that H. pylori colonize human stomach leading to inflammation of gastric mucosa.2 Helicobacter pylori belongs to genus Helicobacter. (thefreelibrary.com)
  • Interestingly, exposure to H. pylori infection was also associated with higher systemic inflammation (as measured by C reactive protein) cross-sectionally, and lower educational attainment. (bmj.com)
  • The ideal approach for the initial diagnosis of Helicobacter pylori infection is to perform an endoscopy to obtain biopsy specimens for histology and culture. (nih.gov)
  • The diagnosis of Helicobacter pylori infection was reached using the 13 C-urea breath test. (isciii.es)
  • Gastric histopathology, iron status and iron deficiency anemia in children with Helicobacter pylori infection. (medscape.com)
  • It is a cross-sectional study, comparing the prevalence of Helicobacter pylori infection (prevalence of IgG antibodies to H. pylori) in the healthy population of Ubrique and Grazalema (mountain location, mortality from stomach cancer 20/100,000) and in Barbate, (coastal location, mortality from stomach cancer 10/100,000) in the province of Cádiz, southern Spain. (springer.com)
  • Importance of childhood sociocconomic status on the current prevalence of Helicobacter pylori infection. (springer.com)
  • Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. (semanticscholar.org)
  • The prevalence of Helicobacter pylori infection was studied in 138 patients with dyspepsia in a hospital in Nakuru, Kenya, and in 138 asymptomatic sex- and age-matched controls from the same population. (cdc.gov)
  • SUEIRO BENAVIDES, R. A. and FERNANDEZ SEARA, J. . Prevalence of Helicobacter pylori infection in the general adult population of the province of Ourense. (isciii.es)
  • to determine the prevalence of Helicobacter pylori infection in the general adult population of the province of Ourense. (isciii.es)
  • H pylori infection is the most common cause of peptic ulcers . (medlineplus.gov)
  • H. pylori infection is found in about 90 percent of people with ulcers in the duodenum (do-uh-DEE-num), the upper part of the small intestine. (encyclopedia.com)
  • H. pylori infection is also responsible for most gastric (GAS-trik), or stomach, ulcers. (encyclopedia.com)
  • More than 90 % of gastroduodenal ulcers are associated with Helicobacter pylori ( H. pylori, formerly known as Campylobacter pylori ) infection, whether on first presentation or on recurrence. (aetna.com)
  • This test isn't generally recommended solely to diagnose an H. pylori infection because it's more invasive than a breath or stool test, but it may be used to diagnose H. pylori ulcers or if it's needed to rule out other digestive conditions. (mayoclinic.org)
  • CONCLUSIONS: There is sufficient evidence to support the use of anti-H. pylori therapy in patients with duodenal ulcers who have H. pylori infection, triple therapy achieving the best results. (cmaj.ca)
  • A common cause of peptic ulcers, H. pylori infection may be present in more than half the people in the world. (sparrow.org)
  • since CagA positive cases carry the risk of progression of infection toward severe H. pylori associated sequels such as gastric cancer and duodenal ulcers. (unboundmedicine.com)
  • Helicobacter pylori infection is an infection of the stomach and the duodenum, which can cause ulcers . (privatehealth.co.uk)
  • Infection with H. pylori is an important risk factor for stomach and duodenum ulcers. (jgl.hr)
  • The infection with H. pylori increases the risk of developing ulcer disease 4-10 times, and 80% to 85% of patients with stomach ulcers are infected with this bacteria. (jgl.hr)
  • Treatment of the H. pylori infection is recommended for all patients with diagnosed infections and ulcers (gastric or duodenal). (jgl.hr)
  • OBJECTIVES: Eradication of Helicobacter pylori (H. pylori) infection markedly reduces the recurrence of duodenal and gastric ulcers. (ebscohost.com)
  • Helicobacter pylori ( H. pylori or HP) is a bacterium that is the main cause of ulcers occurring in the lining of the upper part of the small intestine (duodenal ulcers) and in the lining of the stomach (gastric ulcers). (empr.com)
  • In fact, most stomach and duodenal ulcers of humans stem from infection with Helicobacter bacteria. (marvistavet.com)
  • 1-8 Chronic infection with H pylori -which is typically acquired in childhood and persists throughout life-causes a variety of chronic diseases: duodenal 9 , ,10 and gastric 11 ulcers, gastric cancer, 12 , ,13 and gastric lymphoma. (aappublications.org)
  • The eradication of Helicobacter pylori not only heals peptic ulcers but also prevents their recurrence and reduces the risk of development of gastric cancer and other H. pylori-associated disorders. (eurekaselect.com)
  • TAK-438 is being tested to treat people who have stomach ulcers and also may or may not have Helicobacter pylori (HP) infection. (clinicaltrials.gov)
  • Infections with H. pylori are mainly acquired in early childhood and can lead to chronic disease outcomes, including peptic ulcers and gastric cancer. (epa.gov)
  • DATA SOURCES: A MEDLINE search for articles published in English between January 1983 and December 1992 with the use of MeSH terms Helicobacter pylori (called Campylobacter pylori before 1990) and duodenal ulcer, gastric cancer, dyspepsia and clinical trial. (cmaj.ca)
  • The order Campylobacterales includes human pathogens such as Helicobacter pylori and Campylobacter jejuni. (wikipedia.org)
  • Effect of Helicobacter. (bmj.com)
  • Effect of Helicobacter pylori eradication on gastric metaplasia of the duodenum. (bmj.com)
  • This assumption is supported by the presence of Helicobacter-like organisms, called GHLOs, in the vomit, feces and saliva of animals that have been infected. (petmd.com)
  • Although dogs and cats may be carriers of Helicobacter, these organisms are specific to dogs and cats. (pethealthnetwork.com)
  • Making matters worse, Helicobacter organisms are able to stimulate extra acid secretion by the stomach tissue. (marvistavet.com)
  • It is unclear what constitutes a few Helicobacter bacteria sharing the stomach with its host peacefully and numerous Helicobacter organisms disrupting the stomach lining integrity and causing disease. (marvistavet.com)
  • Helicobacter organisms are often found in small numbers in normal stomachs. (marvistavet.com)
  • H pylori is the most commonly reported species in human GI infections, but non- H pylori organisms (such as H felis , H heilmannii , and H bizzozeronii ) are more common in dogs and cats. (merckvetmanual.com)
  • Helicobacter organisms have been identified most commonly in the gastric tissue of dogs and cats, especially in the fundus and cardia of the stomach, but they are also found in the intestinal tract. (merckvetmanual.com)
  • There have been sporadic reports of Helicobacter organisms identified in the hepatic tissue of a dog with multifocal necrotizing hepatitis, as well as in healthy cats and in cats with cholangiohepatitis. (merckvetmanual.com)
  • A commercially available rapid urease test to detect production of bacterial urease in gastric biopsies can identify the presence of Helicobacter organisms. (merckvetmanual.com)
  • The results in this study showed that the composition of the intestinal microbiota was very similar between members of the same family, and as such, colonization with organisms highly similar to the infected parent(s) may be a risk factor for H. pylori infection in children. (frontiersin.org)
  • Unlike acute infections, in which the "one microbe-one disease" concept can be applied, disease caused by chronic infectious organisms more likely represent interactions between the infecting organism(s) and a multitude of host and environmental factors including interaction with other infectious agents. (jimmunol.org)
  • The epidemiology of Helicobacter pylori infection. (nih.gov)
  • Helicobacter pylori: epidemiology and routes of transmission. (semanticscholar.org)
  • The first national health survey in Chile, covering a representative sample of the population older than 17 years, made it possible to explore the epidemiology of H. pylori infection and its relation with the geographic distribution of gastric cancer ( 13 ). (aacrjournals.org)
  • Shiota S, Suzuki R, Yamaoka Y. The significance of virulence factors in Helicobacter pylori. (medscape.com)
  • Once bound to CEACAM, Helicobacter pylori can transfer additional proteins, so-called virulence factors, to the stomach cells. (infectioncontroltoday.com)
  • Under normal conditions, the Helicobacter bacteria are benign inhabitants of the intestinal tract, being found in several species, including domestic animals such as dogs, cats, ferrets and pigs, in wild animals such as cheetah's and monkeys, and in humans. (petmd.com)
  • Helicobacter pylori has been isolated in the stomachs of cats, and it is thought that humans may be susceptible to acquiring the bacteria from cats carrying it, or vice versa, but so far this is only an assumption and the frequency of cats found carrying this form of Helicobacter is very low. (petmd.com)
  • Helicobacter pylori (H. pylori) is the most common chronic bacterial infection in humans. (clinicaltrials.gov)
  • Like humans, infection in dogs primarily occurs when they're young, specifically during puppyhood. (pethealthnetwork.com)
  • This mouse model will allow the development of therapeutic agents and vaccines against H. pylori infection in humans. (sciencemag.org)
  • In humans, it appears that Helicobacter infection may indeed cause cancer. (marvistavet.com)
  • Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. (diva-portal.org)
  • Humans are the natural host for Helicobacter pylori and more than half of the world's population are infected with this microorganism. (frontiersin.org)
  • Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity. (medscape.com)
  • A laboratory test called a stool antigen test looks for foreign proteins (antigens) associated with H. pylori infection in your stool. (mayoclinic.org)
  • Mitchell H, English DR, Elliott F, Gengos M, Barrett JH, Giles GG, Forman D. Immunoblotting using multiple antigens is essential to demonstrate the true risk of Helicobacter pylori infection for gastric cancer . (cancervic.org.au)
  • Prevalence of antibodies against heat-stable antigens from Helicobacter pylori in patients with dyspeptic symptoms and normal persons. (springer.com)
  • Oral immunization with purified H. pylori antigens protected mice from bacterial infection. (sciencemag.org)
  • HP infection also induces cancer/testis antigens (CTAs) during or after gastric malignancy. (omicsonline.org)
  • Use of PCR with feces for detection of Helicobacter pylori infections in patients. (asm.org)
  • PCR was performed for the detection of Helicobacter pylori in feces from 24 patients with proven infections. (asm.org)
  • Eradication of H. pylori infection reduces the risk of gastric cancer and recurrence of peptic ulcer disease. (clinicaltrials.gov)
  • Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. (semanticscholar.org)
  • Perhaps, detection and eradication of HP infection might reduce the risk of gastric cancer. (omicsonline.org)
  • Association Between Helicobacter pylori Eradication and Gastric Cancer Incidence: A Systematic Review and Meta-analysis. (medscape.com)
  • Association between helicobacter pylori and gastrointestinal symptoms in children. (medscape.com)
  • Moon A, Solomon A, Beneck D, Cunningham-Rundles S. Positive association between Helicobacter pylori and gastroesophageal reflux disease in children. (medscape.com)
  • Many studies have reported an association between Helicobacter pylori infection and an increased risk of cardiovascular disease. (bmj.com)
  • Ecological study of association between Helicobacter pylori infection and gastric cancer in Taiwan. (springer.com)
  • Some studies suggest an association between Helicobacter pylori infection and skin diseases such as chronic idiopathic urticaria and rosacea. (hkmj.org)
  • There have also been few case reports documenting association between Helicobacter pylori and psoriasis vulgaris, Behçet's disease, alopecia areata, Henoch-Schönlein purpura, and Sweet's syndrome. (hkmj.org)
  • The aim was to quantify the association between Helicobacter pylori infection and gastric cancer mortality at the county of residence. (aacrjournals.org)
  • Shiota S, Matsunari O, Watada M, Yamaoka Y. Serum Helicobacter pylori CagA antibody as a biomarker for gastric cancer in east-Asian countries. (medscape.com)
  • This study was undertaken to compare the pathoclinical findings in gastric adenocarcinoma with serum IgG antibody to Helicobacter pylori. (unboundmedicine.com)
  • Infection with Helicobacter pylori was assessed through serum H. pylori IgG antibody in children with intellectual disabilities (ID). (unboundmedicine.com)
  • Antibody tests may help detect COVID-19 infection - if used at right time. (healthcanal.com)
  • H. pylori infection status was examined with a serum IgG antibody test. (medsci.org)
  • Even though infection with H. pylori can cause disease, most people who have the bacteria in their stomach or intestines never experience any symptoms. (encyclopedia.com)
  • What Are the Signs and Symptoms of H. pylori Infection? (encyclopedia.com)
  • H. pylori infection can cause a variety of symptoms, but the most common one is abdominal pain. (encyclopedia.com)
  • See your primary care doctor if you have signs or symptoms that indicate a complication of H. pylori infection. (mayoclinic.org)
  • For the studies of nonulcer dyspepsia with H. pylori infection the authors assessed H. pylori eradication, the symptoms used as outcome measures and whether validated outcome measures had been used. (cmaj.ca)
  • However, H. pylori infection may cause no symptoms at all. (emedicinehealth.com)
  • If you develop signs and symptoms of a peptic ulcer, your doctor will probably test you for H. pylori infection. (sparrow.org)
  • Most people with H. pylori infection will never have any signs or symptoms. (sparrow.org)
  • Whether there is a benefit to testing for H. pylori infection when you have no signs or symptoms of infection is controversial among doctors. (sparrow.org)
  • However, even if you have not shown any symptoms at all you can still have the infection. (randox.com)
  • The primary aims of the study are to assess the effects of H pylori infection (and its eradication, on a double blind basis) on digestive symptoms and their treatment and on various other aspects of health and quality of life. (bmj.com)
  • Moreover, the mother's symptoms of nausea and vomiting and the use of pacifier were significantly associated with the risk of H pylori infection in children. (medscape.com)
  • Then one day I found a research article by Mihai Belascu titled -"Toxicosis in H.Pylori infection" and immediately identified with the symptoms mentioned in the patients referred to in the article. (helico.com)
  • When I went back to the doctor, he said none of my symptoms are typical to an H.Pylori infection. (helico.com)
  • So my symptoms could not be a result of H.Pylori infection and my lack of appetite is probably psychiatric in origin, likely anorexic. (helico.com)
  • a person can then carry the infection for life and never develop symptoms. (pethealthnetwork.com)
  • What are the symptoms of Helicobacter? (pethealthnetwork.com)
  • This way of proving the presence of bacteria in the body is recommended for all patients who have symptoms suggesting infection, and are older than 45. (jgl.hr)
  • The first symptoms of infection with H. pylori are usually those of an ulcer. (empr.com)
  • Reports in adults suggest that newly established infection is accompanied by mild gastrointestinal symptoms, although no controlled studies have been performed. (aappublications.org)
  • 1 , 2 Acute infection is often silent, with symptoms and disease manifesting later in life, as does an increased risk of H. pylori -related malignancy. (mja.com.au)
  • To estimate the prevalence of H. pylori infection and the precancerous gastric lesions and their relationship, in patients with dyspeptic symptoms who underwent upper gastrointestinal endoscopy at a reference center in the central region of Rio Grande do Sul state, Brazil. (scielo.br)
  • Doctors suspect H. pylori infection from your symptoms. (merckmanuals.com)
  • This study is unique in yielding evidence of the effects of Helicobacter pylori infection on gastric histopathology in a community setting where the study population is not restricted to individuals seeking medical care for symptoms. (bmj.com)
  • OBJECTIVE: To determine (a) the advantages and disadvantages of treatment options for the eradication of Helicobacter pylori and (b) whether eradication of H. pylori is indicated in patients with duodenal ulcer, nonucler dyspepsia and gastric cancer. (cmaj.ca)
  • Randomized Clinical Trial Comparing Two One-Week Triple-Therapy Regimens for the Eradication of Helicobacter pylori Infection and Duodenal Ulcer Healing. (ebscohost.com)
  • Reports on the effect of the eradication of Helicobacter pylori (H. pylori) on the decrease in risk of relapse in duodenal ulcer. (ebscohost.com)
  • Factors modulating the outcome of treatment for the eradication of Helicobacter pylori infection. (biomedsearch.com)
  • However, when a Helicobacter pylori infection is present, this bacterium displaces all other bacteria in the gastrointestinal tract, leaving only Helicobacter bacteria in the stomach. (healthcanal.com)
  • There are many excellent ways to determine if a pet's chronic gastrointestinal problem is being complicated by Helicobacter infection. (marvistavet.com)
  • Is the Subject Area "Gastrointestinal infections" applicable to this article? (plos.org)
  • To determine whether the risk of upper gastrointestinal bleeding in patients taking low dose aspirin (≤ 325 mg/day) is increased in people with Helicobacter pylori infections. (mja.com.au)
  • Diagnosis of H. pylori infection was made by gastric mucosal biopsy, rapid urease test, and serum IgG antibodies. (nih.gov)
  • Correlations among gastric juice pH and ammonia, Helicobacter pylori infection and gastric mucosal histology. (biomedsearch.com)
  • Global Overview of Helicobacter pylori Infections Clinical Trials. (mynewsdesk.com)
  • The Report Helicobacter pylori Infections Global Clinical Trials Review, H2, 2016 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. (mynewsdesk.com)
  • GlobalData's clinical trial report, Helicobacter pylori Infections Global Clinical Trials Review, H2, 2016" provides an overview of Helicobacter pylori Infections clinical trials scenario. (mynewsdesk.com)
  • This report provides top line data relating to the clinical trials on Helicobacter pylori Infections. (mynewsdesk.com)
  • For nonulcer dyspepsia with H. pylori infection the search was limited to placebo-controlled randomized clinical trials. (cmaj.ca)
  • Therefore, the evaluation of real clinical practice using non-interventionist registries will help to improve the design and organization of European Consensus on the management of H. pylori infection, which is the best way to establish healthcare efficiency. (clinicaltrials.gov)
  • To obtain a database registering systematically over a year a large and representative sample of routine clinical practice of European gastroenterologists in order to produce descriptive studies of the management of H. pylori infection. (clinicaltrials.gov)
  • To evaluate H. pylori infection consensus and clinical guidelines implementation in different countries. (clinicaltrials.gov)
  • Nowadays there are Consensus and Clinical Guidelines regarding the infection management at a European level and in most of the states, but no data have shown the level of implementation of these recommendations. (clinicaltrials.gov)
  • Now that Helicobacter pylori is generally accepted as a key aetiological agent in gastric cancer as well as the main agent in peptic ulcer, it can claim to be the most important new discovery in clinical gastroenterology of the last decade, and yet there is no up-to-date book available on the subject that is designed primarily for the clinical gastroenterologist. (booktopia.com.au)
  • Studies of the pathology and clinical signs associated with infections in dogs have not been extensive so we really don't know how damaging the organism is to them. (pethealthnetwork.com)
  • The pathogenesis of H. pylori infection in vivo was studied by adapting fresh clinical isolates of bacteria to colonize the stomachs of mice. (sciencemag.org)
  • 5 The host, and environmental and bacterial factors are important in the clinical manifestations of infections with this bacillus. (hkmj.org)
  • This immunological response may cause local damage as well as influence the clinical course of other diseases, including those outside the stomach, thus, opening the field of extragastric manifestations of HP infection. (hkmj.org)
  • Treatment decisions for dogs and cats should be based on presence of Helicobacter , in combination with appropriate clinical signs and/or gastric lesions. (merckvetmanual.com)
  • This study provides the elements to optimize the design of a clinical trial in this population to examine the efficacy of a dietary intervention to reduce H. pylori infection. (aacrjournals.org)
  • Some patients have mixed infection of both antrum and body with varying clinical effects. (merckmanuals.com)
  • Many patients with H. pylori infection have no noticeable clinical effects. (merckmanuals.com)
  • Clinical and molecular characteristics of the 3 cases of IAAA with H. cinaedi infection are shown in the Table . (cdc.gov)
  • For diagnosis of H. cinaedi infections, methods leading to accurate identification by clinical microbiological laboratories are needed. (cdc.gov)
  • The US Food and Drug Administration has approved several regimens, which are now accepted internationally, for the treatment of H pylori infection in patients with peptic ulcer disease, both gastric and duodenal. (medscape.com)
  • Blaser MJ, Chyou PH, Nomura A. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. (springer.com)
  • Conclusions: These data suggested that weekend therapy with high doses of drugs represents an effective, safe, and inexpensive therapeutic approach for the treatment of H. pylori infection, particularly in patients with duodenal ulcer. (ebscohost.com)
  • Objective: One-week triple therapy has been shown to be effective in Helicobacter pylori eradication and duodenal ulcer healing. (ebscohost.com)
  • Efficacy of Omeprazole One Year after Cure of Helicobacter pylori Infection in Duodenal Ulcer Patients. (ebscohost.com)
  • Objective: We have previously shown that, in duodenal ulcer patients, pH control by omeprazole is less pronounced after cure of Helicobacter pylori infection. (ebscohost.com)
  • To determine whether a preexisting Helicobacter pylori infection increases the risk for developing duodenal or gastric ulcer. (annals.org)
  • Preexisting H. pylori infection increases the risk for subsequent development of either duodenal or gastric ulcer disease. (annals.org)
  • In situ expression of cagA and risk of gastroduodenal disease in Helicobacter pylori-infected children. (medscape.com)
  • Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. (semanticscholar.org)
  • We hope that suitable active agents can either completely prevent infection or inhibit the injection of CagA,' explains Tegtmeyer. (infectioncontroltoday.com)
  • To characterize the immune response, including immunity induced by infection with H. pylori , especially virulent strains ( vacA alleles and cagA gene), by analyzing the cytokine profile and T-cell population present in gastroduodenal diseases in a Brazilian population. (scielo.br)
  • Some studies reported H. pylori infection as a risk factor for coronary artery disease [ 2 , 3 ]. (hindawi.com)
  • Controversy exists concerning the relation between Helicobacter pylori (HP) infection and coronary artery disease (CAD). (dovepress.com)
  • The most common forms of Helicobacter found in dogs are Helicobacter felis and Helicobacter heilmannii . (petmd.com)
  • Gastric Helicobacter felis , Helicobacter heilmannii , Helicobacter rappini , and Helicobater salomonis infection. (petmd.com)
  • The most common forms of Helicobacter found in cats are Helicobacter felis and Helicobacter heilmannii . (petmd.com)
  • Using the BALB/c strain of mice, we show that Toxoplasma gondii infection in a host infected with Helicobacter felis alters the natural outcome of T. gondii infection, allowing uncontrolled tachyzoite replication and severe organ damage. (jimmunol.org)
  • In addition, infection with T. gondii alters the specific H. felis immune response, converting a previously resistant host to a susceptible phenotype. (jimmunol.org)
  • The main cause is thought to be the bacterium Helicobacter pylori (H. pylori). (infectioncontroltoday.com)
  • Around half of the global population is chronically infected with the stomach bacterium Helicobacter pylori, almost 1% of whom go on to develop gastric adenocarcinoma, one of the deadliest forms of cancer. (healthcanal.com)
  • Helicobacter pylori infection and the development of gastric cancer. (semanticscholar.org)
  • Chronic infection with Helicobacter pylori is the strongest known risk factor for the development of gastric cancer. (frontiersin.org)
  • There is abundant evidence of the association between chronic infection with Helicobacter pylori and the development of gastric cancer ( 1 - 5 ). (aacrjournals.org)
  • Figueiredo C, Machado JC, Yamaoka Y. Pathogenesis of Helicobacter pylori Infection. (medscape.com)
  • Pathogenesis of Helicobacter pylori infection. (semanticscholar.org)
  • Antibiotic resistance to clarithromycin has been identified as one of the major factors affecting our ability to cure H. pylori infection, and the rate of resistance to this antibiotic seems to be increasing in many geographical areas [ 16 - 19 ]. (hindawi.com)
  • A study by Yoon et al investigated the efficacy of a moxifloxacin-containing triple therapy as second-line therapy for H pylori infection as well as the effect of treatment duration and antibiotic resistance on the eradication rate. (medscape.com)
  • Aetna considers AmHPR Helicobacter pylori antibiotic resistance next generation sequencing panel experimental and investigational because of insufficient evidence of its effectiveness. (aetna.com)
  • A few months ago, working in collaboration with the Austrian Society of Gastroenterology and Hepatology, a team of researchers led by infectionologist Christoph Steininger from the Division of Infectious Diseases and Tropical Medicine at MedUni Vienna's Department of Medicine I conducted a large-scale study into antibiotic resistance of Helicobacter pylori in Austria. (healthcanal.com)
  • Polymorphisms in the host CYP2C19 gene and antibiotic-resistance attributes of Helicobacter pylori isolates influence the outcome of triple therapy. (annals.org)
  • Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. (semanticscholar.org)
  • Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. (semanticscholar.org)
  • The relationship between H. pylori infection and gastroesophageal reflux disease is very complex and not fully explored. (jgl.hr)
  • Treatment of the infection is recommended for all patients who, due to gastroesophageal reflux disease, require long-term or permanent treatment with anti-secretory drugs (the so-called PPIs - proton pump inhibitors). (jgl.hr)
  • Clarithromycin is an antibiotic that is used to treat many different types of bacterial infections affecting the skin and respiratory system. (emedicinehealth.com)
  • RESEARCH DESIGN AND METHODS We examined the association between serological evidence of chronic viral and bacterial infections and incident diabetes in a prospective cohort of Latino elderly. (diabetesjournals.org)
  • Similar therapeutic approaches can be developed to treat various types other bacterial infections. (pnas.org)
  • A gastric pathology resembling human disease was observed in infections with cytotoxin-producing strains but not with noncytotoxic strains. (sciencemag.org)
  • H. pylori possesses numerous elements to successfully colonize the gastric mucosa, establish chronic infection, and induce gastric pathology. (frontiersin.org)
  • Since the discovery of Helicobacter pylori by Warren and Marshall [ Marshall and Warren, 1984 ] in 1982, much has been learned about this Gram-negative microaerophilic bacterium and its associated pathology. (pubmedcentralcanada.ca)
  • 05 Efficacy of proton pump inhibitor-based triple therapy in Helicobacter pylori infected patients with peptic ulcer disease versus functional dyspepsia. (uva.nl)
  • However, whether Helicobacter pylori infection induces CCL20 in human gastric epithelial cells remains to be determined. (asm.org)
  • and (iii) persistent infection induces chronic inflammatory and immune responses that can induce lesions both local and remote sites from the primary infection site [ 7 , 8 ]. (medsci.org)
  • If you have a peptic ulcer and an H pylori infection, treatment is recommended. (medlineplus.gov)
  • You will need to be tested again after treatment to make sure the infection is gone. (medlineplus.gov)
  • After 30 years of experience in H. pylori treatment, however, the ideal regimen to treat this infection has still to be found. (hindawi.com)
  • Helicobacter pylori infection in children: recommendations for diagnosis and treatment. (medscape.com)
  • Compare all 49 medications used in the treatment of Helicobacter Pylori Infection . (drugs.com)
  • More specifically, this data is used as an indicator of the presence of a Helicobacter Pylori ("HP") infection in the stomach as well as of the effectiveness of treatment for an HP infection in the stomach. (google.com.au)
  • Presently treatment for HP infections often involves use of a combination of drugs including antibiotics and components that directly increase the pH of the gastric juice. (google.com.au)
  • To diagnose and monitor the results of treatment for HP infection, serological methods may not be optimal, since antibodies may remain the blood for months after an infection is eliminated. (google.com.au)
  • The high costs that this infection carries both socially and to the health system require the continuous and systematic assessment of the diagnostic and treatment strategies, as well as the accessibility to diagnostic methods and most efficient drugs. (clinicaltrials.gov)
  • The use of a liposomal formulation of linolenic acid to kill Helicobacter pylori bacteria in the stomach represents a powerful treatment option for H. pylori infection, as well as its associated gastroduodenal diseases. (pnas.org)
  • Here, we investigated the in vivo therapeutic potential of liposomal linolenic acid (LipoLLA) for the treatment of H. pylori infection. (pnas.org)
  • LipoLLA treatment was also shown to reduce the levels of proinflammatory cytokines including interleukin 1β, interleukin 6, and tumor necrosis factor alpha, which were otherwise elevated because of the H. pylori infection. (pnas.org)
  • Collectively, results from this study indicate that LipoLLA is a promising, effective, and safe therapeutic agent for the treatment of H. pylori infection. (pnas.org)
  • It was found that Helicobacter pylori infection is often resistant to standard antibiotics and therefore requires alternative forms of treatment. (healthcanal.com)
  • At present, there are no effective therapies for gastric cancer and growing spread of antibiotic resistances is further complicating treatment of the infection. (infectioncontroltoday.com)
  • Given that the antibodies may be present in the body for years after curing the H. pylori infection, this method is not used to determine the success of treatment of this infection. (jgl.hr)
  • Probiotics with triple therapy plus a 14-day course of treatment did not improve the eradication of H. pylori infection (OR 1.44, 95% CI: 0.87, 2.39) compared to the placebo. (nature.com)
  • Objectives: The aim of the present study was to evaluate the efficacy and the safety of a short-term regimen (weekend therapy) in the cure of Helicobacter pylori infection and to analyze the factors that may influence the success of the treatment. (ebscohost.com)
  • The lack of knowledge regarding the pathogenicity of Helicobacter infections in dogs and cats makes treatment decisions difficult. (merckvetmanual.com)
  • H. pylori infection is curable with administration of multiple antimicrobials, and antimicrobial resistance is a leading cause of treatment failure. (jcvi.org)
  • ii) associations of H. pylori infection with epidemiological factors (age, sex, transit through refugee camps, comorbidities and treatment interventions). (mja.com.au)
  • Increasing age is a strong predictor of infection and antimalarial treatment may have a protective effect. (mja.com.au)
  • The typical treatment for Helicobacter pylori infections is currently increased risk of developing stomach cancer -- antibiotics. (infectioncontroltoday.com)
  • The scientists are currently researching various approaches in order to replace current types of treatment for Helicobacter pylori infection, due to the aforementioned side effects. (infectioncontroltoday.com)
  • An additional treatment option being considered is immunization against the HopQ protein and thus vaccination against infection with the bacterium. (infectioncontroltoday.com)
  • After treatment, doctors will repeat breath or stool tests to make sure the infection is gone. (merckmanuals.com)
  • The purpose of this study is to assess efficacy of a new 14-day sequential therapy for the rescue treatment of refractory Helicobacter pylori infection, and whether it is safe while maintaining an ideal eradication rates. (clinicaltrials.gov)
  • Seiji Shiota and Yoshio Yamaoka, "Strategy for the Treatment of Helicobacter pylori Infection", Current Pharmaceutical Design (2014) 20: 4489. (eurekaselect.com)
  • Study treatment will depend upon the Helicobacter pylori infection status of the participant, and include bismuth-containing quadruple therapy for the first 2 weeks in H pylori infected (HP+) participants. (clinicaltrials.gov)
  • and how the traditional risk factors for ulcer disease, such as smoking, aspirin, and alcohol, interact with H. pylori infection. (nih.gov)
  • Blecker U. Helicobacter pylori-associated gastroduodenal disease in childhood. (medscape.com)
  • Different studies investigated the relationship between ischemic heart disease and chronic infection. (hindawi.com)
  • Helicobacter pylori is the cause of most peptic ulcer disease and a primary risk factor for gastric cancer. (aafp.org)
  • Although chronic infections have been associated with increased levels of inflammatory cytokines and cardiovascular disease, there is limited evidence on how infections affect risk of diabetes. (diabetesjournals.org)
  • Our findings indicate that, contrary to some previous suggestions, the association that exists between cardiovascular disease and H pylori infection is not accounted for by any increase in blood pressure. (bmj.com)
  • Helicobacter pylori plays an important role in the pathogenesis of human gastric disease. (asm.org)
  • Seasonal Variation in the Frequency of Helicobacter pylori Infection: A Possible Cause of the Seasonal Occurrence of Peptic Ulcer Disease. (ebscohost.com)
  • Helicobacter pylori is a Gram-negative bacterium that has been linked to peptic ulcer disease, gastric lymphoma, and gastric carcinoma. (hkmj.org)
  • It is possible that without additional stomach disease (such as inflammatory bowel disease ) or other factors (stress, anxiety), Helicobacter causes no trouble plus there are many strains and types of Helicobacter and not all of them cause harm. (marvistavet.com)
  • Some Helicobacter species are also capable of producing toxins but the role of such toxins in this disease process is not clear. (marvistavet.com)
  • Helicobacter seems to be one reason why an animal who has been stable with inflammatory bowel disease or some other stomach disease might suddenly get much worse. (marvistavet.com)
  • Preventing H pylori infection may help reduce pediatric diarrheal disease. (aappublications.org)
  • Studies have reported a higher prevalence of Helicobacter pylori ( H. pylori ) infection in Parkinson's disease. (dovepress.com)
  • The frequency of H. pylori infection was 48.3% in the Parkinson's disease group and 21.7% in controls ( P =0.048). (dovepress.com)
  • Long-term infection with H. pylori significantly increases the risk of developing site-specific diseases, such as peptic ulcer disease ( 1 ), gastric adenocarcinoma ( 2 , 3 ), and mucosa-associated lymphoid tissue lymphoma ( 3 , 4 ). (frontiersin.org)
  • Thus, oral immunization with killed H. pylori may be feasible approach to protect hosts from this infection and the accompanying gastroduodenal disease. (asm.org)
  • Epidemiological studies have suggested that H. pylori infection might be involved in the pathogenesis of coronary heart disease [ 4 - 6 ]. (medsci.org)
  • Arrhythmia is a common disease around the world and Helicobacter pylori ( H. pylori ) is a bacterium infecting 28% to 84% of subjects, depending on the population tested. (mdpi.com)
  • Objectives Helicobacter pylori infection, linked to gastric cancer, is responsible for a large worldwide disease burden. (bmj.com)
  • The strong association between H. pylori infection and peptic ulcer disease is unarguable. (pubmedcentralcanada.ca)
  • The host immune response plays a critical role in determining disease manifestations of chronic infections. (jimmunol.org)
  • Inadequate immune response may fail to control infection, although in other cases the specific immune response may be the cause of tissue damage and disease. (jimmunol.org)
  • The majority of patients with chronic infections are infected by more than one organism yet the interaction between multiple active infections is not known, nor is the impact on disease outcome clear. (jimmunol.org)
  • Chronic Helicobacter (H.) pylori infection is an etiological factor related to gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. (srce.hr)
  • Unfortunately, with the increasing rise in antimicrobial resistance there has been an associated increase in the failure rate of standard triple therapy for H pylori infection. (medscape.com)
  • Since cure of H. pylori infection facilitates healing and decreases recurrence rates, antibiotic therapy is indicated for all H. pylori -infected ulcer patients. (aetna.com)
  • In the developing countries where H. pylori is endemic in the environment, fecal-oral infection through drinking of water contaminated by H. pylori -infected patients' feces is an important infection route ( 6 ). (frontiersin.org)
  • Gastric carcinoma (GC) develops in only 1%-3% of Helicobacter pylori ( H. pylori ) infected people. (wjgnet.com)
  • Because of the increased rate of morbidity and mortality associated with Helicobacter infections in people, concern of zoonotic transmission has been raised (see below). (merckvetmanual.com)
  • Chronic infections are the cause of considerable morbidity and mortality. (jimmunol.org)
  • Helicobacter pylori ( H pylori ) is a type of bacteria that infects the stomach. (medlineplus.gov)
  • Helicobacter pylori is a bacteria that infects the stomach and small intestine of dogs, cats and people. (pethealthnetwork.com)
  • 60 years and diabetes-free in 1998-1999, whose blood was tested for antibodies to herpes simplex virus 1, varicella virus, cytomegalovirus, Helicobacter pylori , and Toxoplasma gondii and who were followed until June 2008. (diabetesjournals.org)
  • Toxoplasma gondii and Helicobacter pylori impart considerable burdens to public health. (epa.gov)
  • Screening of asymptomatic persons for H. pylori infection. (aetna.com)
  • Acute infection, acquired most likely by ingestion of the organism, is most commonly asymptomatic but may be associated with epigastric burning, abdominal distention or bloating, belching, nausea, flatulence, and halitosis. (aafp.org)
  • Infection may be asymptomatic or result in varying degrees of dyspepsia. (merckmanuals.com)
  • H. pylori infection in asymptomatic residents of Nakuru, Kenya, was more prevalent in older persons, with a rate of 68%, than in those 31-40 years of age. (cdc.gov)
  • Swatek J, Wronecki L, Ciechanek R, Szumiło J. Asymptomatic gastric heterotopia in the rectum with Helicobacter pylori infection. (termedia.pl)