Heart Ventricles: The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Heart: The hollow, muscular organ that maintains the circulation of the blood.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Cerebral Ventricles: Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).Third Ventricle: A narrow cleft inferior to the CORPUS CALLOSUM, within the DIENCEPHALON, between the paired thalami. Its floor is formed by the HYPOTHALAMUS, its anterior wall by the lamina terminalis, and its roof by EPENDYMA. It communicates with the FOURTH VENTRICLE by the CEREBRAL AQUEDUCT, and with the LATERAL VENTRICLES by the interventricular foramina.Fourth Ventricle: An irregularly shaped cavity in the RHOMBENCEPHALON, located between the MEDULLA OBLONGATA; the PONS; and the isthmus in front, and the CEREBELLUM behind. It is continuous with the central canal of the cord below and with the CEREBRAL AQUEDUCT above, and through its lateral and median apertures it communicates with the SUBARACHNOID SPACE.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Lateral Ventricles: Cavity in each of the CEREBRAL HEMISPHERES derived from the cavity of the embryonic NEURAL TUBE. They are separated from each other by the SEPTUM PELLUCIDUM, and each communicates with the THIRD VENTRICLE by the foramen of Monro, through which also the choroid plexuses (CHOROID PLEXUS) of the lateral ventricles become continuous with that of the third ventricle.Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.Cerebral Ventricle Neoplasms: Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Heart Transplantation: The transference of a heart from one human or animal to another.Fetal Heart: The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.Heart Atria: The chambers of the heart, to which the BLOOD returns from the circulation.Myocardial Contraction: Contractile activity of the MYOCARDIUM.Heart Valves: Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.Ventricular Function: The hemodynamic and electrophysiological action of the HEART VENTRICLES.Ventricular Function, Left: The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.Heart Block: Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Heart Function Tests: Examinations used to diagnose and treat heart conditions.Myocytes, Cardiac: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).Heart Septum: This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.Endocardium: The innermost layer of the heart, comprised of endothelial cells.Ventricular Function, Right: The hemodynamic and electrophysiological action of the right HEART VENTRICLE.Stroke Volume: The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Chordae Tendineae: The tendinous cords that connect each cusp of the two atrioventricular HEART VALVES to appropriate PAPILLARY MUSCLES in the HEART VENTRICLES, preventing the valves from reversing themselves when the ventricles contract.Truncus Arteriosus: The arterial trunk arising from the fetal heart. During development, it divides into AORTA and the PULMONARY ARTERY.Tricuspid Valve: The valve consisting of three cusps situated between the right atrium and right ventricle of the heart.Mitral Valve: The valve between the left atrium and left ventricle of the heart.Heart Murmurs: Heart sounds caused by vibrations resulting from the flow of blood through the heart. Heart murmurs can be examined by HEART AUSCULTATION, and analyzed by their intensity (6 grades), duration, timing (systolic, diastolic, or continuous), location, transmission, and quality (musical, vibratory, blowing, etc).Heart Auscultation: Act of listening for sounds within the heart.Phonocardiography: Graphic registration of the heart sounds picked up as vibrations and transformed by a piezoelectric crystal microphone into a varying electrical output according to the stresses imposed by the sound waves. The electrical output is amplified by a stethograph amplifier and recorded by a device incorporated into the electrocardiograph or by a multichannel recording machine.Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.Blalock-Taussig Procedure: A cardiovascular procedure performed to create a blood supply to the PULMONARY CIRCULATION. It involves making a connection between the subclavian, or carotid branch of the AORTA, or the AORTIC ARCH to the PULMONARY ARTERY.Fontan Procedure: A procedure in which total right atrial or total caval blood flow is channeled directly into the pulmonary artery or into a small right ventricle that serves only as a conduit. The principal congenital malformations for which this operation is useful are TRICUSPID ATRESIA and single ventricle with pulmonary stenosis.Norwood Procedures: A set of surgical procedures performed to establish sufficient outflow to the systemic circulation in individuals with univentricular congenital heart malformations, such as HYPOPLASTIC LEFT HEART SYNDROME, and MITRAL VALVE atresia, associated with systemic outflow obstruction. Follow-on surgeries may be performed and consist of a HEMI-FONTAN PROCEDURE as the stage 2 Norwood procedure and a FONTAN PROCEDURE as the stage 3 Norwood procedure.PhiladelphiaHeart Bypass, Right: Diversion of the flow of blood from the entrance to the right atrium directly to the pulmonary arteries, avoiding the right atrium and right ventricle (Dorland, 28th ed). This a permanent procedure often performed to bypass a congenitally deformed right atrium or right ventricle.Tricuspid Valve Insufficiency: Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.Papillary Muscles: Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Ventricular Premature Complexes: A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.Tricuspid Valve Stenosis: The pathologic narrowing of the orifice of the TRICUSPID VALVE. This hinders the emptying of RIGHT ATRIUM leading to elevated right atrial pressure and systemic venous congestion. Tricuspid valve stenosis is almost always due to RHEUMATIC FEVER.Antarctic Regions: The continent lying around the South Pole and the southern waters of the Atlantic, Pacific, and Indian Oceans. It includes the Falkland Islands Dependencies. (From Webster's New Geographical Dictionary, 1988, p55)Myoglobin: A conjugated protein which is the oxygen-transporting pigment of muscle. It is made up of one globin polypeptide chain and one heme group.Perciformes: The most diversified of all fish orders and the largest vertebrate order. It includes many of the commonly known fish such as porgies, croakers, sunfishes, dolphin fish, mackerels, TUNA, etc.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Fishes: A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.Seals, Earless: The family Phocidae, suborder PINNIPEDIA, order CARNIVORA, comprising the true seals. They lack external ears and are unable to use their hind flippers to walk. It includes over 18 species including the harp seal, probably the best known seal species in the world.

Phasic right coronary artery blood flow in conscious dogs with normal and elevated right ventricular pressures. (1/10358)

We studied phasic right coronary blood flow in well trained normal dogs and dogs with pulmonic stenosis. We installed electromagnetic flow transducers and pressure tubes under anesthesia to monitor right coronary blood flow, cardiac output, central aortic blood pressure, and right ventribular pressure. In normotensive dogs, systolic flow amplitude equaled early diastolic flow levels. The ratio of systolic to diastolic flow at rest was substantially greater in the right coronary bed (36+/-1.3%) than in the left circumflex bed (13+/-3.6%). Right diastolid flow runoff, including the cove late in diastole, resembled left circumflex runoff. Blood flow to the normotensive right (37+/-1.1 ml/min 100(-1) g) and the left (35+/-1.0 ml/min(-1) g) ventricular myocardium indicated equal perfusion of both cardiac walls. Throttling of systolic flow was related directly to the right ventricular systolic pressure level in the dogs with pulmonic stenosis. Retrograde systolic flow occurred in severe right ventricular hypertension. The late diastolic runoff pattern in dogs with pulmonic stenosis appeared the same as for the normotensive dogs. We obtained systolic to diastolic flow ratios of 1/3 the value of normotensive hearts in high and severe pulmonic hypertension. Electrocardiograms and studies of pathology suggested restricted blood flow to the inner layers of the right myocardium in the dogs with severe and high right ventricular hypertension. Normotensive and hypertensive peak hyperemic flow responses were similar, except for an increased magnitude of diastolic flow, with proportionately less systolic flow in hypertensive states.  (+info)

Regulation of chamber-specific gene expression in the developing heart by Irx4. (2/10358)

The vertebrate heart consists of two types of chambers, the atria and the ventricles, which differ in their contractile and electrophysiological properties. Little is known of the molecular mechanisms by which these chambers are specified during embryogenesis. Here a chicken iroquois-related homeobox gene, Irx4, was identified that has a ventricle-restricted expression pattern at all stages of heart development. Irx4 protein was shown to regulate the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain-1 (VMHC1) and suppressing the expression of the atrial myosin heavy chain-1 (AMHC1) in the ventricles. Thus, Irx4 may play a critical role in establishing chamber-specific gene expression in the developing heart.  (+info)

Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis. (3/10358)

Insulin-like growth factor (IGF)-1 inhibits apoptosis, but its mechanism is unknown. Myocyte stretching activates p53 and p53-dependent genes, leading to the formation of angiotensin II (Ang II) and apoptosis. Therefore, this in vitro system was used to determine whether IGF-1 interfered with p53 function and the local renin-angiotensin system (RAS), decreasing stretch-induced cell death. A single dose of 200 ng/ml IGF-1 at the time of stretching decreased myocyte apoptosis 43% and 61% at 6 and 20 hours. Ang II concentration was reduced 52% at 20 hours. Additionally, p53 DNA binding to angiotensinogen (Aogen), AT1 receptor, and Bax was markedly down-regulated by IGF-1 via the induction of Mdm2 and the formation of Mdm2-p53 complexes. Concurrently, the quantity of p53, Aogen, renin, AT1 receptor, and Bax was reduced in stretched myocytes exposed to IGF-1. Conversely, Bcl-2 and the Bcl-2-to-Bax protein ratio increased. The effects of IGF-1 on cell death, Ang II synthesis, and Bax protein were the consequence of Mdm2-induced down-regulation of p53 function. In conclusion, the anti-apoptotic impact of IGF-1 on stretched myocytes was mediated by its capacity to depress p53 transcriptional activity, which limited Ang II formation and attenuated the susceptibility of myocytes to trigger their endogenous cell death pathway.  (+info)

Adenoviral gene transfer of the human V2 vasopressin receptor improves contractile force of rat cardiomyocytes. (4/10358)

BACKGROUND: In congestive heart failure, high systemic levels of the hormone arginine vasopressin (AVP) result in vasoconstriction and reduced cardiac contractility. These effects are mediated by the V1 vasopressin receptor (V1R) coupled to phospholipase C beta-isoforms. The V2 vasopressin receptor (V2R), which promotes activation of the Gs/adenylyl cyclase system, is physiologically expressed in the kidney but not in the myocardium. Expression of a recombinant V2R (rV2R) in the myocardium could result in a positive inotropic effect via the endogenous high concentrations of AVP in heart failure. METHODS AND RESULTS: A recombinant adenovirus encoding the human V2R (Ad-V2R) was tested for its ability to modulate the cardiac Gs/adenylyl cyclase system and to potentiate contractile force in rat ventricular cardiomyocytes and in H9c2 cardiomyoblasts. Ad-V2R infection resulted in a virus concentration-dependent expression of the transgene and led to a marked increase in cAMP formation in rV2R-expressing cardiomyocytes after exposure to AVP. Single-cell shortening measurements showed a significant agonist-induced contraction amplitude enhancement, which was blocked by the V2R antagonist, SR 121463A. Pretreatment of Ad-V2R-infected cardiomyocytes with AVP led to desensitization of the rV2R after short-term agonist exposure but did not lead to further loss of receptor function or density after long-term agonist incubation, thus demonstrating resistance of the rV2R to downregulation. CONCLUSIONS: Adenoviral gene transfer of the V2R in cardiomyocytes can modulate the endogenous adenylyl cyclase-signal transduction cascade and can potentiate contraction amplitude in cardiomyocytes. Heterologous expression of cAMP-forming receptors in the myocardium could lead to novel strategies in congestive heart failure by bypassing the desensitized beta-adrenergic receptor signaling.  (+info)

An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia. (5/10358)

Cellular ischemia results in activation of a number of kinases, including p38 mitogen-activated protein kinase (MAPK); however, it is not yet clear whether p38 MAPK activation plays a role in cellular damage or is part of a protective response against ischemia. We have developed a model to study ischemia in cultured neonatal rat cardiac myocytes. In this model, two distinct phases of p38 MAPK activation were observed during ischemia. The first phase began within 10 min and lasted less than 1 h, and the second began after 2 h and lasted throughout the ischemic period. Similar to previous studies using in vivo models, the nonspecific activator of p38 MAPK and c-Jun NH2-terminal kinase, anisomycin, protected cardiac myocytes from ischemic injury, decreasing the release of cytosolic lactate dehydrogenase by approximately 25%. We demonstrated, however, that a selective inhibitor of p38 MAPK, SB 203580, also protected cardiac myocytes against extended ischemia in a dose-dependent manner. The protective effect was seen even when the inhibitor was present during only the second, sustained phase of p38 MAPK activation. We found that ischemia induced apoptosis in neonatal rat cardiac myocytes and that SB 203580 reduced activation of caspase-3, a key event in apoptosis. These results suggest that p38 MAPK induces apoptosis during ischemia in cardiac myocytes and that selective inhibition of p38 MAPK could be developed as a potential therapy for ischemic heart disease.  (+info)

Taurine modulates I(Kr) but I(Ks) in guinea-pig ventricular cardiomyocytes. (6/10358)

1. Effects of taurine on the delayed rectifier K+ current (I(K)) in isolated guinea-pig ventricular cardiomyocytes were examined at different intracellular Ca2+ concentration ([Ca2+]i), using whole-cell voltage and current clamp techniques. Experiments were performed at 36 degrees C. 2. Addition of taurine (10-20 mM) decreased the action potential duration (APD) at pCa 8, but increased the APD at pCa 6. Taurine (20 mM) enhanced I(K) at 70 mV by 22.4 +/- 3.1% (n = 6, P < 0.01) at pCa 8, whereas taurine inhibited the I(K) by 27.1 +/- 2.7% (n = 6, P < 0.01) at pCa 6. These responses behaved in a concentration-dependent manner. 3. The I(K) is composed of the rapid and slow components (I(Kr) and I(Ks)). When [Ca2+]i was pCa 6, taurine at 20 mM reduced the tail current of I(Kr) at 70 mV by 16.5 +/- 2.7% (n = 5, P < 0.05) and that of I(Ks) at 70 mV by 27.1 +/- 2.8% (n = 6, P < 0.01). In contrast, at pCa 8, the tail currents of I(Kr) and I(Ks) at 70 mV were enhanced by 13.4 +/- 3.2% (n = 7, P < 0.05) and by 22.4 +/- 3.1% (n = 7, P < 0.01), respectively. The voltages of half-maximum activation (V1/2) for I(Kr) and I(Ks) were not modified by taurine. 4. Addition of E-4031 (5 microM) to taurine had a complete blockade of the tail current of I(Kr), but not I(Ks). The remained tail current (I(Ks)) in the presence of E-4031 (5 microM) was not affected by taurine (20 mM), but was blocked by 293B (30 microM). 5. These results indicate that taurine modulates I(Kr) but not I(Ks), depending on [Ca2+]i, resulting in regulation of the APD.  (+info)

A comparison of an A1 adenosine receptor agonist (CVT-510) with diltiazem for slowing of AV nodal conduction in guinea-pig. (7/10358)

1. The purpose of this study was to compare the pharmacological properties (i.e. the AV nodal depressant, vasodilator, and inotropic effects) of two AV nodal blocking agents belonging to different drug classes; a novel A1 adenosine receptor (A1 receptor) agonist, N-(3(R)-tetrahydrofuranyl)-6-aminopurine riboside (CVT-510), and the prototypical calcium channel blocker diltiazem. 2. In the atrial-paced isolated heart, CVT-510 was approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50 = 41 nM) than to increase coronary conductance (EC50 = 200 nM). At concentrations of CVT-510 (40 nM) and diltiazem (1 microM) that caused equal prolongation of S-H interval (approximately 10 ms), diltiazem, but not CVT-510, significantly reduced left ventricular developed pressure (LVP) and markedly increased coronary conductance. CVT-510 shortened atrial (EC50 = 73 nM) but not the ventricular monophasic action potentials (MAP). 3. In atrial-paced anaesthetized guinea-pigs, intravenous infusions of CVT-510 and diltiazem caused nearly equal prolongations of P-R interval. However, diltiazem, but not CVT-510, significantly reduced mean arterial blood pressure. 4. Both CVT-510 and diltiazem prolonged S-H interval, i.e., slowed AV nodal conduction. However, the A1 receptor-selective agonist CVT-510 did so without causing the negative inotropic, vasodilator, and hypotensive effects associated with diltiazem. Because CVT-510 did not affect the ventricular action potential, it is unlikely that this agonist will have a proarrythmic action in ventricular myocardium.  (+info)

Effects of tumour necrosis factor-alpha on left ventricular function in the rat isolated perfused heart: possible mechanisms for a decline in cardiac function. (8/10358)

1. The cardiac depressant actions of TNF were investigated in the isolated perfused rat heart under constant flow (10 ml min(-1)) and constant pressure (70 mmHg) conditions, using a recirculating (50 ml) mode of perfusion. 2. Under constant flow conditions TNF (20 ng ml(-1)) caused an early (< 25 min) decrease in left ventricular developed pressure (LVDP), which was maintained for 90 min (LVDP after 90 min: control vs TNF; 110 +/- 4 vs 82 +/- 10 mmHg, P < 0.01). 3. The depression in cardiac function seen with TNF under constant flow conditions, was blocked by the ceramidase inhibitor N-oleoylethanolamine (NOE), 1 microM, (LVDP after 90 min: TNF vs TNF with NOE; 82 +/- 10 vs 11 +/- 5 mmHg, P < 0.05). 4. In hearts perfused at constant pressure, TNF caused a decrease in coronary flow rate (change in flow 20 min after TNF: control vs TNF; -3.0 +/- 0.9 vs -8.7 +/- 1.2 ml min(-1), P < 0.01). This was paralleled by a negative inotropic effect (change in LVDP 20 min after TNF: control vs TNF; -17 +/- 7 vs -46 +/- 6 mmHg, P < 0.01). The decline in function was more rapid and more severe than that seen under conditions of constant flow. 5. These data indicate that cardiac function can be disrupted by TNF on two levels, firstly via a direct, ceramidase dependant negative inotropic effect, and secondly via an indirect coronary vasoconstriction.  (+info)

  • In addition to these two abnormalities, the heart may have a hole between the two ventricles (a ventricular septal defect, VSD). (news-medical.net)
  • Patients with associated ECG features of LBBB and echo evdence of dyssynchrony (left and right ventricles not working in unison) also benefit by implanting a special pacemaker called bi-ventricular pacemaker. (ndtv.com)
  • Congestive heart failure takes place when the heart is unable to maintain an adequate circulation of blood in the bodily tissues or to pump out the venous blood returned to it by the veins (Merriam-Webster). (bartleby.com)
  • After the pause, the electrical impulse travels through the bundle of his and through right and left bundles that branch into the right and left ventricles respectively. (bartleby.com)
  • From there, researchers could control and monitor the calcium propagation and insert a catheter to study the pressure and volume of the beating ventricle. (eurekalert.org)
  • Human heart ventricle (left) tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. (creativebiomart.net)
  • The human heart ventricle (left) tissue was frozen in liquid nitrogen immediately after excision and then stored at -70?C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. (creativebiomart.net)
  • Pravdin S, Dierckx H, Markhasin VS, Panfilov A. Drift of scroll wave filaments in an anisotropic model of the left ventricle of the human heart. (ugent.be)
  • The evidence for significant improvements in the contractile function of the left ventricle myocardium, as well as in patients' cognitive and emotional states, was observed in CHF patients after combined treatment with FSC. (emcell.com)
  • Impaired function of the left ventricle in Ebstein's malformation has also been described. (ucl.ac.uk)
  • The aim of this study was to retrospectively analyze risk factors for death after second-stage palliation of single-ventricle heart and to compare therapeutic results achieved with the hemi-Fontan and bidirectional Glenn procedures. (pubmedcentralcanada.ca)
  • Second-stage palliation of single-ventricle heart performed with the hemi-Fontan method consists of anastomosing the superior vena cava (SVC) with the pulmonary arteries close to the SVC insertion to the right atrium, while the SVC insertion is separated from the right atrial cavity by means of a transverse patch sutured to the right atrial walls. (pubmedcentralcanada.ca)
  • Today, surgical palliation of single-ventricle CHD is expected to result in favorable short- and long-term outcomes into early adulthood for most patients. (mhmedical.com)
  • In this respect, when concluding our first review, we explained how the arterial trunks were also formed by septation within the solitary outflow tract of the primary heart tube. (bmj.com)
  • Children operated with single-ventricle palliation between January 1994 and December 2017 operated in Sweden will be included retrospectively. (bioportfolio.com)
  • The left ventricle pumps blood into the systemic circulation for the rest of the body. (wikidoc.org)
  • In most studies of the heart, researchers have focused on the more-easily-imaged left ventricle, the region of the heart affected by systemic high blood pressure and other common conditions," said study author Steven Kawut, M.D., M.S. , associate professor of Medicine and Epidemiology and director of the Pulmonary Vascular Disease Program at Penn. (healthcanal.com)
  • She initially required extracorporeal membrane oxygenation support and was transitioned to Berlin Heart systemic VAD. (northwestern.edu)
  • Oxygenated blood enters the systemic circulation when leaving the left ventricle, through the aortic semilunar valve. (hyperleap.com)
  • A sinus of Valsalva aneurysm is a potential site of thrombus formation which may embolize to the systemic and cerebral circulation as well as the coronary [elynsgroup.com] We are reporting a twelve year old child with hyperdynamic circulation being diagnosed and treated as Rheumatic heart disease . (symptoma.com)
  • Systemic output is provided by the right ventricle and ductus arteriosus, with admixture of systemic and pulmonary venous return occurring via left-to-right shunting at the atrial level. (mhmedical.com)
  • 1 In this issue of Heart , Kim and colleagues present a timely study looking at the impact of RV dysfunction on the clinical outcomes of septic shock. (bmj.com)
  • The unique transcatheter approach of the AccuCinch system aims to treat the dilation and dysfunction of the left ventricle by placing a cable around the perimeter of the chamber's interior wall and fastening it in place using a series of anchors. (fiercebiotech.com)
  • Increased PP1 could result in the decreased PLN-Ser 16 and inhibition of PP1 is a potential therapeutic target for heart dysfunction in pediatrics. (biomedcentral.com)
  • atresia or hypoplasia of the ventricle associated with the affected atrioventricular or semilunar valve typically exists in conjunction with the valve abnormality. (mhmedical.com)
  • The Fetal Heart Program at CHOP will monitor baby and mother throughout the pregnancy and create a plan for labor and care after the birth. (chop.edu)
  • The Fetal Heart Program team will also discuss delivery in the Garbose Family Special Delivery Unit (SDU). (chop.edu)
  • Fetal right ventricles have complex flow patterns featuring two interacting diastolic vortex rings, formed during diastolic E-wave and A-wave. (physiology.org)
  • So fetal heart echo at 24 weeks from some very good ultrasonologist trained in fetal echo is must to know the exact diagnosis .Without complete diagnosis it is impossible to say whether it is life threatening or not. (healthcaremagic.com)
  • The doctors and nurses of Mount Sinai's Fetal Heart Program are dedicated to treating your infant as early as possible. (mountsinai.org)
  • The European study hopes to register about 130 patients with reduced ejection fraction systolic heart failure. (fiercebiotech.com)
  • Ancora has enrolled the first participant in its planned multi-center study , which hopes to register about 130 European patients with reduced ejection fraction systolic heart failure. (fiercebiotech.com)
  • Ángel Luis Sánchez Bayón, a 66-year-old resident of Cadreita (Navarre), had a left ventricle with less than 15% capacity of ejection (blood pumping), added to which was a serious coronary pathology and diabetes as principal associated diseases. (healthcanal.com)
  • However, this carried-over kinetic energy did not significantly alter the work done by the heart for ejection. (physiology.org)
  • Ancora Heart kicked off a European clinical study for its device designed to directly repair an enlarged left ventricle from the inside, as a treatment for patients suffering from heart failure. (fiercebiotech.com)
  • The company estimates that about half of patients with heart failure have an enlarged left ventricle, which causes more stress on the heart as it tries to pump blood to the body. (fiercebiotech.com)
  • This is the second clinical test of the AccuCinch system focused specifically on heart failure and an enlarged left ventricle-the company began enrolling patients in a U.S. feasibility study this past May (PDF). (fiercebiotech.com)
  • Many patients have a conduction delay of the right ventricle. (rug.nl)
  • In these patients it is important to determine the end-systolic phase independently for the right and left ventricle. (rug.nl)
  • There is moderate to strong correlation between CMR and 2D echo in the assessment of LV function parameters and mass in patients with ischemic heart failure. (nih.gov)
  • A comparative study was carried out on patients with CHF to examine the effect of combined treatment, including the experimental application of FSCs, on the morphofunctional parameters of the left ventricle and cognitive functions. (emcell.com)
  • The control group consisted of 20 CHF patients of similar age, sex, and New York Heart Association class. (emcell.com)
  • Rowlinson, G , Dupont, E , Daubeney, P and Severs, NJ (2008) Connexin40 is expressed in the right ventricles of patients with congenital heart malformations In: 28th Annual Meeting of the European Section of the International-Society-for-Heart-Research, 2008-05-28 - 2008-05-31, Athens, GREECE. (surrey.ac.uk)
  • A total of 90 patients with acute left ventricle heart failure treated in our hospital from February 2015 to February 2017 were randomly selected as the objects according to the order of admission and divided into study group (n=45) as well as control group (n=45). (alliedacademies.org)
  • According to the order of admission, we randomly selected 90 patients with acute left ventricle heart failure who were treated in our hospital from February 2015 to February 2017 to conduct the study with the results summarized as follows. (alliedacademies.org)
  • A total of 90 patients with acute left ventricle heart failure who were treated in our hospital from February 2015 to February 2017 were selected as the objects and divided into study group (n=45) as well as control group (n=45) after being diagnosed to have acute left ventricle heart failure and being approved by the ethics committee. (alliedacademies.org)
  • The ventricles' pressure, volume and contraction rate could be measured as they are in patients. (childrenshospital.org)
  • Studies with the chip revealed that heart cells in patients with Barth syndrome contracted weakly and produced an excess of reactive oxygen species (ROS). (childrenshospital.org)
  • Why are heart failure specialists seeing more patients with ARVC/D? (heart.org)
  • As a result, ARVC/D patients eventually develop heart failure. (heart.org)
  • Two patients with mild pulmonary hypertension died 1 month and 10 months, respectively, after heart transplantation and biventricular assist device implantation to support the failing graft. (biomedcentral.com)
  • Heart transplantation in failed Fontan circulation, though technically challenging, may be offered in this difficult group of patients who are otherwise hopeless. (biomedcentral.com)
  • In community, adult patients in whom a one-and-a-half ventricle working order is required could be contemplate oned," concurring to the makers, who combined that their novella percutaneous treatment ascendancy on the dole for sons if smaller desires are elbow. (piwip.com)
  • Systolic and lusitropic function increased at faster heart rates in IPAH patients, but were markedly blunted in SSc-PAH. (nih.gov)