The transference of a heart from one human or animal to another.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transference of a part of or an entire liver from one human or animal to another.
The hollow, muscular organ that maintains the circulation of the blood.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
The transference of a kidney from one human or animal to another.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The transference of either one or both of the lungs from one human or animal to another.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
Transplantation of an individual's own tissue from one site to another site.
Prospective patient listings for appointments or treatments.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Elements of limited time intervals, contributing to particular results or situations.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Transference of an organ between individuals of the same species or between individuals of different species.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
The transference of a pancreas from one human or animal to another.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
The period following a surgical operation.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
A pumping mechanism that duplicates the output, rate, and blood pressure of the natural heart. It may replace the function of the entire heart or a portion of it, and may be an intracorporeal, extracorporeal, or paracorporeal heart. (Dorland, 28th ed)
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
The inferior and superior venae cavae.
Pumping that aids the natural activity of the heart. (Dorland, 27th ed)
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Application of a life support system that circulates the blood through an oxygenating system, which may consist of a pump, a membrane oxygenator, and a heat exchanger. Examples of its use are to assist victims of smoke inhalation injury, respiratory failure, and cardiac failure.
The innermost layer of the heart, comprised of endothelial cells.
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The chambers of the heart, to which the BLOOD returns from the circulation.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The return of a sign, symptom, or disease after a remission.
Examinations used to diagnose and treat heart conditions.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
The omission of atrial activation that is caused by transient cessation of impulse generation at the SINOATRIAL NODE. It is characterized by a prolonged pause without P wave in an ELECTROCARDIOGRAM. Sinus arrest has been associated with sleep apnea (REM SLEEP-RELATED SINUS ARREST).
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Surgery performed on the heart or blood vessels.
Disease having a short and relatively severe course.
An operation that uses stimulated latissimus dorsi muscle (SKELETAL MUSCLE VENTRICLE) to assist cardiac function. The latissimus dorsi muscle is mobilized from the chest wall and moved into the thorax through the bed of the resected 2nd or 3rd rib. The muscle is then wrapped around the left and right ventricles and stimulated to contract during cardiac systole by means of an implanted burst-stimulator. (Stedman, 26th ed)
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Tissues, cells, or organs transplanted between genetically different individuals of the same species.
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
Pathological conditions in the INTESTINES that are characterized by the gastrointestinal loss of serum proteins, including SERUM ALBUMIN; IMMUNOGLOBULINS; and at times LYMPHOCYTES. Severe condition can result in HYPOGAMMAGLOBULINEMIA or LYMPHOPENIA. Protein-losing enteropathies are associated with a number of diseases including INTESTINAL LYMPHANGIECTASIS; WHIPPLE'S DISEASE; and NEOPLASMS of the SMALL INTESTINE.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Condition where a primary dysfunction of either heart or kidney results in failure of the other organ (e.g., HEART FAILURE with worsening RENAL INSUFFICIENCY).
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Transplantation between animals of different species.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.
A condition caused by underdevelopment of the whole left half of the heart. It is characterized by hypoplasia of the left cardiac chambers (HEART ATRIUM; HEART VENTRICLE), the AORTA, the AORTIC VALVE, and the MITRAL VALVE. Severe symptoms appear in early infancy when DUCTUS ARTERIOSUS closes.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
The treatment of patients without the use of allogeneic BLOOD TRANSFUSIONS or blood products.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Partial or total replacement of the CORNEA from one human or animal to another.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
A state of elevated cardiac output due to conditions of either increased hemodynamic demand or reduced cardiac oxygen output. These conditions may include ANEMIA; ARTERIOVENOUS FISTULA; THYROTOXICOSIS; PREGNANCY; EXERCISE; FEVER; and ANOXIA. In time, compensatory changes of the heart can lead to pathological form of high cardiac output and eventual HEART FAILURE.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Contractile activity of the MYOCARDIUM.
A dead body, usually a human body.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
A procedure in which total right atrial or total caval blood flow is channeled directly into the pulmonary artery or into a small right ventricle that serves only as a conduit. The principal congenital malformations for which this operation is useful are TRICUSPID ATRESIA and single ventricle with pulmonary stenosis.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Members of a religious denomination founded in the United States during the late 19th century in which active evangelism is practiced, the imminent approach of the millennium is preached, and war and organized government authority in matters of conscience are strongly opposed (from American Heritage Dictionary of the English Language, 4th ed). Jehovah's Witnesses generally refuse blood transfusions and other blood-based treatments based on religious belief.
The veins and arteries of the HEART.
Shock resulting from diminution of cardiac output in heart disease.
Abnormally rapid heartbeats originating from one or more automatic foci (nonsinus pacemakers) in the HEART ATRIUM but away from the SINOATRIAL NODE. Unlike the reentry mechanism, automatic tachycardia speeds up and slows down gradually. The episode is characterized by a HEART RATE between 135 to less than 200 beats per minute and lasting 30 seconds or longer.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
An infant during the first month after birth.
A voluntary organization concerned with the prevention and treatment of heart and vascular diseases.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Pathological processes of the LIVER.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
Institutions specializing in the care of patients with heart disorders.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.
Counterpulsation in which a pumping unit synchronized with the patient's electrocardiogram rapidly fills a balloon in the aorta with helium or carbon dioxide in early diastole and evacuates the balloon at the onset of systole. As the balloon inflates, it raises aortic diastolic pressure, and as it deflates, it lowers aortic systolic pressure. The result is a decrease in left ventricular work and increased myocardial and peripheral perfusion.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
The period before a surgical operation.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.
A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atrial and ventricular premature beats, and are also known as extra or ectopic heartbeats. Their frequency is increased in heart diseases.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
The field of nursing care concerned with the promotion, maintenance, and restoration of health.
Surgery performed on the heart.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The dimension of the physical universe which, at a given place, orders the sequence of events. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Therapy with two or more separate preparations given for a combined effect.
A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.
A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).

ECG diagnosis of native heart ventricular tachycardia in a heterotopic heart transplant recipient. (1/3176)

A case is reported of haemodynamic collapse in a 51 year old male heterotopic heart transplant recipient caused by native heart ventricular tachycardia. An accurate diagnosis was made by selective right and left sided electrocardiography. Synchronised electrical cardioversion of the native heart (200 J) resulted in restoration of sinus rhythm with prompt relief of symptoms and amelioration of the clinical situation.  (+info)

Reversal of severe pulmonary hypertension with beta blockade in a patient with end stage left ventricular failure. (2/3176)

A 52 year old man with severe chronic left ventricular failure (New York Heart Association class IV) was considered unsuitable for cardiac transplantation because of high and irreversible pulmonary vascular resistance (PVR). In an attempt to produce symptomatic improvement, metoprolol was cautiously introduced, initially at 6.25 mg twice daily. This was slowly increased to 50 mg twice daily over a two month period and continued thereafter. After four months of treatment the patient's symptoms had improved dramatically. His exercise tolerance had increased and diuretic requirements reduced to frusemide 160 mg/day only. Assessment of right heart pressures was repeated and, other than a drop in resting heart rate, there was little change in his pulmonary artery pressure or PVR. His right heart pressures were reassessed showing a pronounced reduction in pulmonary artery pressure and a significant reduction in PVR, which fell further with inhaled oxygen and sublingual nitrates. He was then accepted onto the active waiting list for cardiac transplantation. A possible mechanism of action was investigated by assessing responses to beta agonists during treatment. Not only was there pronounced improvement in PVR but it was also demonstrated that beta receptor subtype cross-regulation may have contributed to the mechanism of benefit.  (+info)

Clinical significance of expression of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow transplant recipients as determined by nucleic acid sequence-based amplification. (3/3176)

Human cytomegalovirus (HCMV) infection was monitored retrospectively by qualitative determination of pp67 mRNA (a late viral transcript) by nucleic acid sequence-based amplification (NASBA) in a series of 50 transplant recipients, including 26 solid-organ (11 heart and 15 lung) transplant recipients (SOTRs) and 24 bone marrow transplant recipients (BMTRs). NASBA results were compared with those obtained by prospective quantitation of HCMV viremia and antigenemia and retrospective quantitation of DNA in leukocytes (leukoDNAemia). On the whole, 29 patients were NASBA positive, whereas 10 were NASBA negative, and the blood of 11 patients remained HCMV negative. NASBA detected HCMV infection before quantitation of viremia did but after quantitation of leukoDNAemia and antigenemia did. In NASBA-positive blood samples, median levels of viremia, antigenemia, and leukoDNAemia were significantly higher than the relevant levels detected in NASBA-negative HCMV-positive blood samples. By using the quantitation of leukoDNAemia as the "gold standard," the analytical sensitivity (47.3%), as well as the negative predictive value (68. 3%), of NASBA for the diagnosis of HCMV infection intermediate between that of antigenemia quantitation (analytical sensitivity, 72. 3%) and that of viremia quantitation (analytical sensitivity, 28.7%), while the specificity and the positive predictive value were high (90 to 100%). However, with respect to the clinically relevant antigenemia cutoff of >/=100 used in this study for the initiation of preemptive therapy in SOTRs with reactivated HCMV infection, the clinical sensitivity of NASBA reached 100%, with a specificity of 68. 9%. Upon the initiation of antigenemia quantitation-guided treatment, the actual median antigenemia level was 158 (range, 124 to 580) in SOTRs who had reactivated infection and who presented with NASBA positivity 3.5 +/- 2.6 days in advance and 13.5 (range, 1 to 270) in the group that included BMTRs and SOTRs who had primary infection (in whom treatment was initiated upon the first confirmation of detection of HCMV in blood) and who presented with NASBA positivity 2.0 +/- 5.1 days later. Following antiviral treatment, the durations of the presence of antigenemia and pp67 mRNA in blood were found to be similar. In conclusion, monitoring of the expression of HCMV pp67 mRNA appears to be a promising, well-standardized tool for determination of the need for the initiation and termination of preemptive therapy. Its overall clinical impact should be analyzed in future prospective studies.  (+info)

Use of cardiopulmonary exercise testing with hemodynamic monitoring in the prognostic assessment of ambulatory patients with chronic heart failure. (4/3176)

OBJECTIVES: We studied whether direct assessment of the hemodynamic response to exercise could improve the prognostic evaluation of patients with heart failure (HF) and identify those in whom the main cause of the reduced functional capacity is related to extracardiac factors. BACKGROUND: Peak exercise oxygen consumption (VO2) is one of the main prognostic variables in patients with HF, but it is influenced also by many extracardiac factors. METHODS: Bicycle cardiopulmonary exercise testing with hemodynamic monitoring was performed, in addition to clinical evaluation and radionuclide ventriculography, in 219 consecutive patients with chronic HF (left ventricular ejection fraction, 22 +/- 7%; peak VO2, 14.2 +/- 4.4 ml/kg/min). RESULTS: During a follow-up of 19 +/- 25 months, 32 patients died and 6 underwent urgent transplantation with a 71% cumulative major event-free 2-year survival. Peak exercise stroke work index (SWI) was the most powerful prognostic variable selected by Cox multivariate analysis, followed by serum sodium and left ventricular ejection fraction, for one-year survival, and peak VO2 and serum sodium for two-year survival. Two-year survival was 54% in the patients with peak exercise SWI < or = 30 g x m/m2 versus 91% in those with a SWI >30 g x m/m2 (p < 0.0001). A significant percentage of patients (41%) had a normal cardiac output response to exercise with an excellent two-year survival (87% vs. 58% in the others) despite a relatively low peak VO2 (15.1 +/- 4.7 ml/kg/min). CONCLUSIONS: Direct assessment of exercise hemodynamics in patients with HF provides additive independent prognostic information, compared to traditional noninvasive data.  (+info)

T cell repertoire alterations of vascularized xenografts. (5/3176)

The role of T cells in the rejection of vascularized xenografts has been little explored. Because of the high potential diversity of xenoantigens, it has been suggested that xenotransplantation could induce a strong cellular response that could contribute to delayed rejection. Alternatively, alterations in molecular interactions could impair the T cell response. Because the analysis of TCR repertoire in vivo indirectly reflects the nature and the magnitude of T cell xenorecognition, we took advantage of the possibility of obtaining long term survival of hamster heart xenografts in rat recipients treated with a combination of cobra venom factor and cyclosporin A (CsA), to analyze T cell infiltration and, for the first time, V beta TCR usage, at the complementarity-determining region 3 level, in accommodated and rejected xenografts, compared with allografts. After withdrawal of CsA (on day 40), the analysis of V beta family expression and corresponding complementarity-determining region 3 lengths in rejected xenografts revealed a Gaussian pattern, in contrast to a much more restricted pattern in rejected allografts (p = 0.002), suggesting that, after withdrawal of CsA, all the underrepresented T cell clones are rapidly expanded in xenografts. These results correlate with the rapid kinetics of rejection (4 +/- 1 days), the high number of T cells, the rapid expression of markers of activation (IL-2 receptor alpha-chain and class II receptor), and the strong deposit of IgG Abs in rejected xenografts. Taken together, these results suggest that the intensity and diversity of the T cell response to xenografts could be stronger than the response to allografts in vivo.  (+info)

Sympathetic rhythmicity in cardiac transplant recipients. (6/3176)

BACKGROUND: Variability of R-R interval and muscle sympathetic nerve activity (MSNA) occurs predominantly at a low frequency (LF, +/-0.1 Hz) and a high frequency (HF, +/-0.25 Hz) in normal humans. Increased sympathetic drive in normal humans is associated with an increased LF component of the R-R interval and MSNA. Patients with severe heart failure have high sympathetic activity but decreased or absent LF power of both R-R and MSNA. We tested the hypothesis that this dysfunction in autonomic modulation in heart failure can be reversed by heart transplantation. METHODS AND RESULTS: We performed spectral analysis of resting MSNA, R-R interval, and respiration in 9 patients with heart transplants, 9 chronic heart failure patients, and 9 normal control subjects, all closely matched for age, sex, and body mass index. MSNA (bursts per minute) was higher in patients with heart transplants (74+/-3) than either patients with heart failure (56+/-6) or normal subjects (40+/-4) (P<0.001). LF variability in the R-R interval was reduced in both heart transplant recipients and heart failure patients compared with the control subjects (P<0.01). The LF variability in MSNA was also nearly absent in the heart failure patients (P<0.01). However, the LF and HF oscillations in MSNA in patients with heart transplants were comparable to those evident in the control subjects. CONCLUSIONS: Cardiac transplantation does not reduce MSNA. However, LF oscillations in sympathetic activity are restored after transplantation such that the MSNA oscillatory profile is similar to that observed in normal subjects.  (+info)

High and low pulmonary vascular resistance in heart transplant candidates. A 5-year follow-up after heart transplantation shows continuous reduction in resistance and no difference in complication rate. (7/3176)

BACKGROUND: In heart transplantation candidates, high pulmonary vascular resistance has been found to decrease promptly after heart transplantation without any further reduction during follow-up. Pulmonary hypertension has been described as associated with an increased peri- and postoperative complication rate and mortality. This study describes the evolution of pulmonary vascular resistance and the outcome for patients during 5 years following heart transplantation. METHODS AND RESULTS: Haemodynamic data, complication rate and mortality have been analysed during 5-year follow-up in all patients (n = 80) who were heart transplanted at Sahlgrenska University Hospital from 1988 through 1990. We found a significant and continuous reduction in pulmonary vascular resistance both in patients with a pre-operative high (> 3 Wood Units; n = 36), but reversible on nitroprusside, and pre-operative low (< or = 3 Wood Units; n = 44) pulmonary vascular resistance. A multivariate analysis showed that a pre-operative high mean pulmonary artery and low mean pulmonary capillary wedge pressure predicted the decline in pulmonary vascular resistance during 5 years after heart transplantation. The need for a postoperative assist device, complication rate, and early and late mortality were independent of the pre-operative level of pulmonary vascular resistance. CONCLUSIONS: A continuous reduction in pulmonary vascular resistance during 5 years following heart transplantation was found in patients with both high, but reversible, and low pre-operative resistance levels. The outcome and survival were independent of the pre-operative pulmonary vascular resistance level.  (+info)

Incidence and clinical relevance of coronary calcification detected by electron beam computed tomography in heart transplant recipients. (8/3176)

BACKGROUND: Patients treated by cardiac transplantation who survive beyond one year are at significant risk from fatal coronary artery disease. The development of coronary artery calcification in these patients is discussed and methods available to detect it are reviewed. OBJECTIVES: To assess the clinical importance of coronary artery calcium in heart transplant recipients. METHODS: In a cohort of 102 cardiac transplant recipients, electron beam computed tomography was used to measure calcium in the coronary arterial wall 63 days to 9.1 years (median 4.6 years) after transplantation. The results were compared with angiographic findings and with conventional coronary disease risk factors. The patients were followed for a mean of 2.12 years (1.2-4.02 years) to assess the relationship between these findings and future cardiac events. RESULTS: Forty-one (40.2%) had a stenosis of > 24% in one or more major coronary artery at angiography. Forty-six (45%) had a coronary calcium score > 0. The absence of calcium had a negative predictive value with respect to angiographic disease in any vessels of 87.5%. Logistic regression revealed that dyslipidaemia, systemic hypertension and organ ischaemic time were significant predictors of calcification. At follow-up, both an abnormal coronary angiogram and coronary calcium were found to be the only significant predictors of late events. Multivariate analysis suggested that the detection of coronary calcium did not offer any additional predictive information over that provided by the angiogram itself. CONCLUSION: Electron beam computed tomography is well suited to the assessment of calcium in the coronary arteries of heart transplant recipients, although the mechanisms of this calcification remain poorly understood. Calcium is detected more frequently than would be suggested by studies using intravascular ultrasound. It is associated with the presence of angiographic disease, and with some conventional risk factors for coronary disease. At follow-up the presence of coronary calcium was associated with an adverse clinical outcome, as it is in conventional ischaemic heart disease.  (+info)

Cardiac transplantation is frequently associated with accelerated coronary atherosclerosis and immune-mediated microvascular injury. To determine if orthotopic cardiac transplantation impairs the capacity of the coronary vasculature to vasodilate and conduct hyperemic blood flow, maximal coronary vasodilator reserve was measured in 25 cardiac allograft recipients with no evidence of rejection 6-57 months after transplantation and in 20 normal subjects. Left ventricular wall thickness was assessed echocardiographically, and epicardial coronary anatomy was evaluated by quantitative coronary angiography. Coronary vasodilator reserve (CVDR) was measured in all patients with a coronary Doppler catheter and a maximally vasodilating dose of intracoronary papaverine. CVDR measured in the transplant recipients with normal coronary arteries, left ventricular function, and wall thickness (5.0 +/- 0.3 [mean +/- SEM] peak/resting velocity; range, 3.8-7.3; n = 16) was not different from that of normal ...
Improving recovery time following heart transplantation: the role of the multidisciplinary health care team Maureen G Roussel,1 Noreen Gorham,2 Lynn Wilson,2 Abeel A Mangi2 1Heart and Vascular Center, Yale-New Haven Hospital, New Haven, CT, USA; 2Center for Advanced Heart Failure, Mechanical Circulatory Support and Cardiac Transplantation, Yale New Haven Heart and Vascular Institute, Yale-New Haven Hospital, New Haven, CT, USA Background: The care of cardiac transplant patients is complex requiring a finely orchestrated endeavor to save a patient’s life. Given the chronic and complex nature of these patients, multiple disciplines are involved in their care. Recognizing difficulties with communication among team members and striving for improved efficiencies in our pretransplant listing process and in our inpatient care, our team was prompted to change the existing approach to patient care related to heart transplantation. Methods: Daily multidisciplinary rounds were instituted and the format of
TY - JOUR. T1 - Aortic dissections following heart transplantations. AU - Skalsky, Ivo. AU - Urban, Marian. AU - Malouskova, Jana. AU - Szarszoi, Ondrej. AU - Pirk, Jan. AU - Netuka, Ivan. PY - 2012/1. Y1 - 2012/1. N2 - Background: Aortic dissection in a cardiac allograft is an uncommon complication of heart transplantation with only few cases reported in the literature. Method: We report a case of 46-year-old female who underwent orthotopic heart transplantation for dilated cardiomyopathy 22 years earlier. During surveillance echocardiographic examination she was diagnosed with type A aortic dissection limited to the donor aorta. The aortic root was successfully replaced using a valve-sparing David procedure. The pathogenesis and surgical management of these dissections is reviewed. Conclusion: Appropriate surgical repair performed in a timely fashion leads to excellent results improving the prognosis of these patients.. AB - Background: Aortic dissection in a cardiac allograft is an uncommon ...
History:. Now called the Pediatric Heart Transplant Society (PHTS), the Pediatric Heart Transplant Study Registry was established in 1993 by a group of physicians who wanted to improve the lives of children who needed a heart transplant. The primary purposes of the organization was to establish and maintain a prospective, event driven database for heart transplantation, to encourage and stimulate basic and clinical research in the field of pediatric heart transplantation, and to promote new therapeutic strategies. The ultimate goal was to improve the lives of pediatric heart transplant recipients.. With more than 25 years of data collection, PHTS has produced over 120 abstract presentations and over 80 peer-reviewed manuscripts analyzing the continuum from pre-transplant risk factors to post-transplant morbidities which impact long-term survival after heart transplant in childhood. Information gained has significantly increased our understanding of pediatric heart transplantation and has allowed ...
Now called the Pediatric Heart Transplant Society (PHTS), the Pediatric Heart Transplant Study Registry was established in 1993 by a group of physicians who wanted to improve the lives of children who needed a heart transplant. The primary purposes of the organization was to establish and maintain a prospective, event driven database for heart transplantation, to encourage and stimulate basic and clinical research in the field of pediatric heart transplantation, and to promote new therapeutic strategies. The ultimate goal was to improve the lives of pediatric heart transplant recipients.. With more than 25 years of data collection, PHTS has produced over 120 abstract presentations and over 90 peer-reviewed manuscripts analyzing the continuum from pre-transplant risk factors to post-transplant morbidities which impact long-term survival after heart transplant in childhood. Information gained has significantly increased our understanding of pediatric heart transplantation and has allowed pediatric ...
TY - JOUR. T1 - Sinus tachycardia is associated with impaired exercise tolerance following heart transplantation. AU - Peled, Yael. AU - Varnado, Sara. AU - Lowes, Brian D. AU - Zolty, Ronald. AU - Lyden, Elizabeth R.. AU - Moulton, Michael J. AU - Um, John Y. AU - Raichlin, Eugenia. PY - 2017/5. Y1 - 2017/5. N2 - Background: Sinus tachycardia often presents in heart transplantation (HTx) recipients, but data on its effect on exercise performance are limited. Methods: Based on mean heart rate (HR) value 3 months after HTx, 181 patients transplanted from 2006 to 2015 at University of Nebraska Medical Center were divided into two groups: (i) HR,95 beats/min (bpm, n=93); and (ii) HR≥95 bpm (n=88). Cardiopulmonary exercise testing (CPET) was performed 1 year after HTx. Results: Mean HR at 3 months post-HTx was 94±11 bpm and did not change significantly at 1 year post-HTx (96±11 bpm, P=.13). HR≥95 bpm at 3 months was associated with younger donor age (OR 1.1; CI 1.0-1.1, P=.02), female donors ...
Introduction: Tolerance-inducing cell subsets which can support the organ acceptance following heart transplantation (HTx) can be found among dendritic cells (DCs) and regulatory T cells (Tregs). It is assumed that not a single cell population but an interplay between different cell subsets is responsible to avoid rejection following HTx. However, it is unknown which cell subsets change during tolerance induction and maintenance. Therefore, pre-HTx and long-term HTx (LT-HTx; HTx longer than 5 years ago) patients were investigated for their immunological tolerance-inducing profile and their immune balance.. Methods: Heparinized whole blood samples of n=17 patients with end-stage heart failure (pre-HTx) and n=20 LT-HTx patients without rejection episodes were analyzed by flow cytometry for the DC cell subsets expressing BDCA-1, -2, -3, -4 and for the Treg subsets expressing CD39, CD62L, CD120b and CD147. Percentages and mean fluorescence intensities (MFIs) of the cell subsets were documented. The ...
TY - JOUR. T1 - The yield of surveillance endomyocardial biopsies as a screen for cellular rejection in pediatric heart transplant patients. AU - Levi, Daniel S.. AU - DeConde, Adam S.. AU - Fishbein, Michael C.. AU - Burch, Caron. AU - Alejos, Juan C.. AU - Wetzel, Glenn T.. PY - 2004/2. Y1 - 2004/2. N2 - Endomyocardial biopsy is commonly used to screen for cellular rejection in pediatric heart transplant patients. The yield of EMBs when combined with newly developed immunohistochemical techniques and modern immunosuppression in pediatric heart transplant patients is unknown. After OHT, surveillance biopsies were performed on a routine basis on all pediatric patients. EMBs were also performed on symptomatic OHT patients suspected to have rejection. All positive results (greater than ISHLT grade 1B) were confirmed with immunohistochemical staining. A retrospective review of consecutive EMBs performed in this institution from January 1995 to January 2003 was performed. The echocardiographic ...
Diabetes mellitus (DM) is a major cause of morbidity and mortality following heart transplantation (HT), with 21% and 35% of survivors being affected within 1 and 5 years following HT, respectively. Magnesium deficiency is common among HT patients treated with calcineurin inhibitors and is a known risk factor for DM in non-HT patients. We therefore investigated the association between serum Mg (s-Mg) levels and new-onset diabetes after transplantation (NODAT). Between 2002 and 2017, 102 non-DM HT patients were assessed. In accordance with the mean value of all s-Mg levels recorded during the first year post-HT, patients were divided into high s-Mg (≥ 1.8 mg/dL) and low s-Mg (| 1.8 mg/dL) groups. The endpoint was NODAT, defined according to the diagnostic criteria of the American Diabetes Association. Baseline clinical and demographic characteristics for the high (n = 45) and low s-Mg (n = 57) groups were similar. Kaplan-Meier survival analysis showed that 15-year freedom from NODAT was significantly
TY - JOUR. T1 - Reduction of infectious complications following heart transplantation with triple-drug immunotherapy. AU - Andreone, P. A.. AU - Olivari, M. T.. AU - Elick, B.. AU - Arentzen, C. E.. AU - Sibley, R. K.. AU - Bolman, R. M.. AU - Simmons, R. L.. AU - Ring, W. S.. PY - 1986. Y1 - 1986. UR - UR - M3 - Article. VL - 5. SP - 13. EP - 19. JO - Journal of Heart and Lung Transplantation. JF - Journal of Heart and Lung Transplantation. SN - 1053-2498. IS - 3. ER - ...
TY - JOUR. T1 - Neurologic complications following heart transplantation in the modern era. T2 - Decreased incidence, but postoperative stroke remains prevalent. AU - Jarquin-Valdivia, A. A.. AU - Wijdicks, E. F.M.. AU - McGregor, C.. PY - 1999/8/1. Y1 - 1999/8/1. UR - UR - U2 - 10.1016/S0041-1345(99)00294-8. DO - 10.1016/S0041-1345(99)00294-8. M3 - Article. C2 - 10456001. AN - SCOPUS:0032810429. VL - 31. SP - 2161. EP - 2162. JO - Transplantation Proceedings. JF - Transplantation Proceedings. SN - 0041-1345. IS - 5. ER - ...
TY - JOUR. T1 - Single-Center Experience of Pediatric Heart Transplantation in Taiwan. AU - Chou, N. K.. AU - Chang, C. H.. AU - Chi, N. H.. AU - Chang, C. I.. AU - Chen, Y. S.. AU - Wu, E. T.. AU - Wu, M. H.. AU - Wang, J. K.. AU - Hsu, R. B.. AU - Huang, S. C.. AU - Ko, W. J.. AU - Chu, S. H.. AU - Lin, F. Y.. AU - Wang, S. S.. PY - 2006/9. Y1 - 2006/9. N2 - Heart transplantation (HTx) is a treatment for end-stage heart failure or a complex or inoperable congenital defect. The long-term survival and the adequate donor to recipient body weight (D/R BW) ratio remain to be determined. From March 1995 to May 2004, 14 children (6 months-16 years of age) underwent HTx due to underlying diseases of idiopathic dilated cardiomyopathy (n = 10; 71.4%), congenital heart disease (n = 3; 21.4%), and Kawasaki disease (n = 1; 7.1%). Donor-recipient body weight ratio ranged from 0.89 to 3.9. Big heart syndrome was present in one patient when D/R BW ratio was more than 3. Actuarial survival was 92.9% at 5 years ...
Background- Sudden cardiac death among orthotopic heart transplant recipients is an important mechanism of death after cardiac transplantation. The role for implantable cardioverter-defibrillators (ICDs) in this population is not well established. This study sought to determine whether ICDs are effective in preventing Sudden cardiac death in high-risk heart transplant recipients.. Methods and Results- We retrospectively analyzed the records of all orthotopic heart transplant patients who had ICD implantation between January 1995 and December 2005 at 5 heart transplant centers. Thirty-six patients were considered high risk for sudden cardiac death. The mean age at orthotopic heart transplant was 44±14 years, the majority being male (n=29). The mean age at ICD implantation was 52±14 years, whereas the average time from orthotopic heart transplant to ICD implant was 8 years ±6 years. The main indications for ICD implantation were severe allograft vasculopathy (n=12), unexplained syncope (n=9), ...
TY - JOUR. T1 - The youngest successful heart transplant in the U.K.. T2 - A case report. AU - Yazbeck, Joseph. AU - Young, J Nilas. PY - 1987. Y1 - 1987. N2 - We report a case of dilated cardiomyopathy in a 7 year-old boy who was assessed and treated medically, but failed to respond. A successful orthotopic cardiac transplantation was performed.. AB - We report a case of dilated cardiomyopathy in a 7 year-old boy who was assessed and treated medically, but failed to respond. A successful orthotopic cardiac transplantation was performed.. KW - Cardiomyopathy. KW - Heart surgery. KW - Transplantation. UR - UR - U2 - 10.3109/14017438709106523. DO - 10.3109/14017438709106523. M3 - Article. C2 - 3303310. AN - SCOPUS:0023178145. VL - 21. SP - 191. JO - Scandinavian Cardiovascular Journal. JF - Scandinavian Cardiovascular Journal. SN - 1401-7431. IS - ...
TY - JOUR. T1 - ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation. AU - Kirk, Richard. AU - Dipchand, Anne I.. AU - Davies, Ryan R.. AU - Miera, Oliver. AU - Chapman, Gretchen. AU - Conway, Jennifer. AU - Denfield, Susan. AU - Gossett, Jeffrey G.. AU - Johnson, Jonathan. AU - McCulloch, Michael. AU - Schweiger, Martin. AU - Zimpfer, Daniel. AU - Ablonczy, László. AU - Adachi, Iki. AU - Albert, Dimpna. AU - Alexander, Peta. AU - Amdani, Shahnawaz. AU - Amodeo, Antonio. AU - Azeka, Estela. AU - Ballweg, Jean. AU - Beasley, Gary. AU - Böhmer, Jens. AU - Butler, Alison. AU - Camino, Manuela. AU - Castro, Javier. AU - Chen, Sharon. AU - Chrisant, Maryanne. AU - Christen, Urs. AU - Danziger-Isakov, Lara. AU - Das, Bibhuti. AU - Everitt, Melanie. AU - Feingold, Brian. AU - Fenton, Matthew. AU - Garcia-Guereta, Luis. AU - Godown, Justin. AU - Gupta, Dipankar. AU - Irving, Claire. AU - Joong, Anna. AU - Kemna, Mariska. AU - Khulbey, Sanjeev ...
Median survival after pediatric heart transplantation (HT) is 15 years in the current era. This means that a substantial fraction of patients transplanted during childhood fail to survive to adulthood, or require heart re-transplantation, because of complications related to heart transplant. These complications include heart transplant rejection, infection, coronary artery disease, post-transplant lymphoproliferative disorder (PTLD; a form of lymphoma seen in transplant recipients), and kidney failure. Most complications stem not from the heart transplant itself, but from the drugs commonly used to suppress the immune system in order to prevent rejection. In the US, tacrolimus (TAC) and mycophenolate mofetil (MMF), have emerged over the past decade as the standard of care for pediatric heart transplant immunosuppression. While pediatric survival has improved significantly in the era of TAC and MMF, post-HT complications remain a major problem that limits median survival to 15 years. Recently, ...
TY - JOUR. T1 - A critical analysis of morbidity and mortality as it relates to recipient age following cardiac transplantation. AU - Hosenpud, J. D.. AU - Pantely, G. A.. AU - Norman, D. J.. AU - Cobanoglu, A. M.. AU - Hovaguimian, H.. AU - Starr, A.. PY - 1990/1/1. Y1 - 1990/1/1. N2 - Older patients (age greater than 55) are now being accepted as candidates for cardiac transplantation. The outcome following cardiac transplantation in this older age group has been largely limited to an analysis of mortality and rejection and infection incidence. In addition to these factors, this report investigates whether morbidity related to other organ system disease is greater than in older patients. Seventy-eight cardiac transplant operations in patients aged 15 through 64 have been performed using the identical immunosuppression protocol from December 1985 to May 1989. Of these, 58 patients were under the age of 55 (younger), and 20 were 55 years of age or older (older). One- and 2-yr survival tended to ...
TY - JOUR. T1 - Changing indications for pediatric heart transplantation complex congenital heart disease. AU - Hsu, Daphne T.. AU - Lamour, Jacqueline M.. N1 - Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2015. Y1 - 2015. UR - UR - U2 - 10.1161/CIRCULATIONAHA.114.001377. DO - 10.1161/CIRCULATIONAHA.114.001377. M3 - Review article. C2 - 25561474. AN - SCOPUS:84925581407. VL - 131. SP - 91. EP - 99. JO - Circulation. JF - Circulation. SN - 0009-7322. IS - 1. ER - ...
TY - JOUR. T1 - Multiparametric Cardiac Magnetic Resonance Imaging Can Detect Acute Cardiac Allograft Rejection After Heart Transplantation. AU - Dolan, Ryan S.. AU - Rahsepar, Amir A.. AU - Blaisdell, J.. AU - Suwa, Kenichiro. AU - Ghafourian, Kambiz. AU - Wilcox, Jane E. AU - Khan, Sadiya Sana. AU - Vorovich, Esther Elizabeth. AU - Rich, Jonathan D. AU - Anderson, Allen Sawyer. AU - Yancy, Clyde W. AU - Collins, Jeremy D.. AU - Carr, James. AU - Markl, Michael. PY - 2019/8/1. Y1 - 2019/8/1. N2 - Objectives: The purpose of this study was to evaluate the sensitivity of multiparametric cardiac magnetic resonance imaging (CMR) for the detection of acute cardiac allograft rejection (ACAR). Background: ACAR is currently diagnosed by endomyocardial biopsy, but CMR may be a noninvasive alternative because of its capacity for regional myocardial structure and function characterization. Methods: Fifty-eight transplant recipients (mean age 47.0 ± 14.7 years) and 14 control subjects (mean age 47.7 ± ...
Objective: The aim of this study was to compare the requirement for temporary and permanent pacemaker insertion and the incidence of the problems regarding the rhythm following heart transplantation with the bicaval or biatrial technique in the early postoperative period.Methods: Sixty-one patients underwent orthotopic heart transplantation between the dates of September 1989 and December 2008 in our clinics were included to the study. The study was designed as retrospective analysis, and all data were collected from hospital records. The transplantation was performed by using standard biatrial method in 28 of the patients, by using bicaval anastomosis method in 33 of the patients. Statistical analyses were performed using Chi-square, Fischers exact and Mann-Whitney U tests. Predictors of temporary and permanent pacemaker insertion were analyzed using logistic regression analysis.Results: In the biatrial group, the temporary pacemaker requirement (p|0.05), left bundle branch block (LBBB) (p|0.01) and
Kidney disease is a common problem after heart transplantation. It may be caused by anti-rejection medications such as cyclosporine or tacrolimus. However, the reason why some people develop kidney problems after a heart transplant, but other people do not, is not fully known. This study plans to learn more about the relationship between a persons genetic make-up (DNA; deoxyribonucleic acid) and the risk of kidney problems after a heart transplant. The long-term goal of this research is to identify genetic variations that may help predict the development of kidney problems after heart transplantation ...
TY - JOUR. T1 - Inferior Outcomes on the Waiting List in Low-Volume Pediatric Heart Transplant Centers. AU - Rana, A.. AU - Fraser, C. D.. AU - Scully, B. B.. AU - Heinle, J. S.. AU - McKenzie, E. D.. AU - Dreyer, W. J.. AU - Kueht, Michael. AU - Liu, H.. AU - Brewer, E. D.. AU - Rosengart, T. K.. AU - OMahony, C. A.. AU - Goss, J. A.. PY - 2017/6/1. Y1 - 2017/6/1. N2 - Low case volume has been associated with poor outcomes in a wide spectrum of procedures. Our objective was to study the association of low case volume and worse outcomes in pediatric heart transplant centers, taking the novel approach of including waitlist outcomes in the analysis. We studied a cohort of 6482 candidates listed in the Organ Procurement and Transplantation Network for pediatric heart transplantation between 2002 and 2014; 4665 (72%) of the candidates underwent transplantation. Candidates were divided into groups according to the average annual transplantation volume of the listing center during the study period: ...
Purpose: In the field of kidney transplantation, there is strong support for the beneficial effect of minimizing donor-recipient HLA incompatibility, and HLA-DR matching in particular contributes the most to graft survival and function. However, there are conflicting reports on the effect of donor-recipient HLA-DR matching on outcomes in heart transplantation. A few studies have shown HLA-DR matching reduces the incidence of graft rejection within the first year and increases short term graft survival. It is not known if HLA-DR matching impacts long term outcomes. We sought to analyze the effect of HLA-DR mismatches on long term survival, and also explain possible mechanisms for its impact on survival.. *Methods: All adult heart transplantations performed at our institution from 2000 to 2010 were retrospectively reviewed. Multi-organ transplant recipients, patients who expired within the first year after transplantation and those with missing data were excluded. Patients were grouped according ...
TY - JOUR. T1 - The effect of donor specific transfusions and dietary fatty acids on rat cardiac allograft survival. AU - Perez, Richard V. AU - Waymack, J. Paul. AU - Munda, Rino. AU - Alexander, J. Wesley. PY - 1987. Y1 - 1987. N2 - A rat heterotopic cardiac transplant model was used to study the effect of dietary lipids on the immune response. Animals receiving linoleic acid (LA), oleic acid (OA), and fish oil (FO) enriched diets showed significant prolongation of allograft survival when compared to the control diet fed animals. When LA was given to animals who had received a single donor specific transfusion (DST) augmentation of the beneficial DST effect was observed, while the OA and FO fed groups showed no differences from control DST animals. Dietary regulation of the immune response, possibly through manipulation of arachidonic acid metabolism, is implied.. AB - A rat heterotopic cardiac transplant model was used to study the effect of dietary lipids on the immune response. Animals ...
Alternative wait list strategies for heart transplant recipients have not yet been popularized in Canada. This article from Columbia University explores the concept of matching ñhigh riskî recipients with marginal donor organs. Survival analysis revealed lower post-HTx survival in high risk recipients (82.2 versus 87.4 % at 1-yr; 59.8 versus 76.3 % at 5-yrs post-HTx; p=0.0005). In addition, a prognostic risk score (CARRS) derived from clinical factors stratified survival post-HTx into high risk (3+ points) versus low risk (0-2 points) patients. ...
TY - JOUR. T1 - Effect of position on the residual heart rate variability in patients after orthotopic heart transplantation. AU - Lin, Yi Ying. AU - Lu, Wan An. AU - Hsieh, Yuan Chen. AU - Chang, Hsiao Huang. AU - Shih, Chun Che. AU - Jeng, Mei Jy. AU - Kuo, Cheng Deng. PY - 2017/2/1. Y1 - 2017/2/1. N2 - Background This study investigated the effects of position on heart rate variability (HRV) in patients some years after orthotopic heart transplantation (OHT) surgery. Methods Spectral HRV analysis was performed on 15 patients after OHT and 16 patients with coronary artery disease (CAD). HRV measures were compared between OHT and CAD patients in four randomly ordered positions [supine, right lateral decubitus (RLD), left lateral decubitus (LLD), and upright]. Multivariable linear regression analysis was used to identify the factors associated with cardiac function and HRV of OHT patients in supine position, and the factors associated with the outcome (OHT or CAD) of the patients. Results The ...
Background: Coronary vasculopathy (CAV) is the leading cause of late morbidity and mortality in both adult and pediatric heart transplant (HTx) recipients. Virtual histology intravascular ultrasound (VH-IVUS) may add important information in the evaluation of CAV progression. Indeed, the presence of VH-IVUS derived inflammatory plaques has been found to be associated with higher progression of CAV in adult patient recipients. The aim of this prospective study was to investigate tissue characterization of CAV by VH-IVUS in a pediatric cohort.. Methods: 40 patients (mean age: 17,1 ± 6,7 yrs, male= 23) underwent VH-IVUS analysis of the left anterior descending coronary artery 8.1± 4.6 years after HTx. Based on age, patients were divided in two groups (group A , 18 yrs; group B: ≥ 18 yrs; time from HTx: group A: 6.6 ± 2.9 yrs vs group B: 10.3±4.9 yrs, p=.01). According to VH-IVUS analysis, coronary allograft lesions were divided into inflammatory (VHD-IP) (necrotic core and dense calcium ...
Our long-term goal is to understand early graft events that lead to the shortened lifespan of children receiving heart transplants. Understanding the risk factors for adverse graft outcomes will help determine the best opportunities for prevention and management of factors that lead to shortened life expectancy. In broad terms, we know that donor-specific antibodies (DSA; circulating proteins in the blood that attach to the graft and damage it) lead to poorer long-term graft outcomes. However, not all antibodies are equally damaging.. In Aim 1 of this study, we determine which pediatric heart transplant recipients have DSA in their blood before and after transplant and in year 1 of the study, we have performed multiple additional specialized tests to determine the special characteristics of all these antibodies in order to help us determine which ones are most damaging to the new heart. We believe this will help define a target population for more intensive therapies to prevent and treat bad ...
The purpose of this study is to see if the use of real time ultrasound of heart muscle perfusion is a usable and effective non-invasive way to detect Coronary Allograft Vasculopathy (heart transplant caused blood vessel disease) in child and adult heart transplant patients.. ...
This hospital was formerly the Willis F. Pierce Memorial Hospital. It has 2,200 beds and more than 400 staff members with senior (chief and deputy chief) professional titles. Over 65% of the staff holds masters or doctoral degrees. Its number of allogeneic heart transplants performed leads the nation. Its pediatric heart transplantation and heart re-transplantation fill a gap in this field in China. Its technology in liver transplantation heart re-transplantation and bilateral lung transplantation lead the nation.188. Since its Heart Surgery Department conducted the first orthotopic heart transplant in Fujian Province in 1995, it has successfully performed heart transplants for patients with advanced heart disease from more than 30 cities and regions of China. Its specialty ranks among the best in allogeneic heart transplantation, holds 16 first in the country titles, and serves as the base for heart transplantation in China.. It helped more than 40 large hospitals in large cities such as ...
312 Predicting 1-Year Survival in Pediatric Heart Transplant Candidates with Congenital Heart Disease: An Analysis of the PHTS Database The Journal of Heart and Lung Transplantation Elsevier 1053-2498 10.1016/J.HEALUN.2012.01.320
TY - JOUR. T1 - Replacement of infected aortic prosthetic graft with aortic homograft after heart transplantation. T2 - 13-year follow-up. AU - Macedo, Francisco Igor B. AU - Salerno, Tomas. AU - Pham, Si M.. PY - 2013/5/1. Y1 - 2013/5/1. N2 - Acute ascending aortic dissection (AAAD) is a rare complication after orthotopic heart transplantation. We report a patient with AAAD after heart transplantation in whom repair was complicated by infection of the ascending aortic prosthetic graft. This was successfully managed by re-do replacement with two cryopreserved aortic homografts. Despite extensive calcification in the wall, the homografts show no aneurysm or dilation after 10 years.. AB - Acute ascending aortic dissection (AAAD) is a rare complication after orthotopic heart transplantation. We report a patient with AAAD after heart transplantation in whom repair was complicated by infection of the ascending aortic prosthetic graft. This was successfully managed by re-do replacement with two ...
TY - JOUR. T1 - Partial normalization of the heart rate response to exercise after cardiac transplantation. T2 - Frequency and relationship to exercise capacity. AU - Squires, Ray W.. AU - Leung, Tat Chi. AU - Cyr, Nancy S.. AU - Allison, Thomas G.. AU - Johnson, Bruce D.. AU - Ballman, Karla V.. AU - Wagner, Jean A.. AU - Olson, Lyle J.. AU - Frantz, Robert P.. AU - Edwards, Brooks S.. AU - Kushwaha, Sudhir S.. AU - Dearani, Joseph A.. AU - Daly, Richard C.. AU - McGregor, Christopher G.A.. AU - Rodeheffer, Richard J.. PY - 2002/12/1. Y1 - 2002/12/1. N2 - Objective: To determine the frequency of partial normalization of the heart rate response to graded exercise and its relationship to exercise capacity in cardiac transplant recipients. Subjects and Methods: The study subjects were 95 adults (77 men, 18 women) who were available to perform a cardiopulmonary exercise test 1 year after orthotopic cardiac transplantation, which occurred between June 1988 and September 1998. All subjects received ...
TY - JOUR. T1 - Management of Patients After Cardiac Transplantation. AU - OLSON, LYLE J.. AU - RODEHEFFER, RICHARD J.. PY - 1992/1/1. Y1 - 1992/1/1. N2 - During the past decade, the morbidity and mortality associated with cardiac transplantation have decreased dramatically. The current survival for patients who undergo orthotopic cardiac transplantation is 80 to 90% at 1 year and 70 to 80% at 5 years; these results are attributed chiefly to improved immunosuppression and the consequent decrease in infectious illnesses and rejection. Because surgical mortality and technique have not changed appreciably during the past 20 years, improved survival can be ascribed to advances in the medical management of recipients of cardiac transplants. Medical problems frequently encountered in such patients include allograft rejection, allograft vasculopathy, hypertension, renal dysfunction, hyperlipidemia, hyperglycemia, malignant disorders, general surgical disease, and osteopenic bone disease. Hence, the ...
TY - JOUR. T1 - Early primary graft failure after a pediatric heart transplant and successful rescue with plasmapheresis, immunoglobulins, and alemtuzumab. AU - Raj, Shashi. AU - Ruiz, Phillip. AU - Rusconi, Paolo. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Early primary graft failure after pediatric orthotopic heart transplantation (OHT) has a high mortality rate and can occur due to several causes including but not limited to prolonged graft ischemia time, suboptimal preimplant myocardial preservation, hyperacute rejection, and maladaptation of the graft to the hosts hemodynamic status. Mechanical circulatory support with either extracorporeal membrane oxygenation (ECMO) or ventricular assist device has been used for the rescue of primary graft failure in pediatric patients after heart transplant. Cardiac arrest before ECMO initiation in these patients is associated with adverse neurologic outcome although those surviving to hospital discharge generally have excellent long-term outcome. We report a ...
Background-The effect of donor-recipient human leukocyte antigen (HLA) matching on outcomes remains relatively unexplored in pediatric patients. The objective of this study was to investigate the effects of donor-recipient HLA matching on graft survival in pediatric heart transplantation. Methods and Results-The UNOS database was queried for heart transplants occurring between October 31, 1987 to December 31, 2012 in a recipient aged ≤ 17 with at least one postoperative follow-up visit. Retransplants were excluded. Transplants were divided into 3 donor-recipient matching groups: no HLA matches (HLA-no), 1 or 2 HLA matches (HLA-low), and 3-6 HLA matches (HLA-high). Primary outcome was graft loss. 4471 heart transplants met study inclusion criteria. High degree of donor-recipient HLA matching occurred infrequently; (HLA-high n=269 (6 %) v. HLA-low n=2683 (60%) v. HLA-no n=1495 (34%). There were no differences between HLA matching groups in frequency of coronary vasculopathy (p=0.19) or rejection ...
TY - JOUR. T1 - Sirolimus Therapy Is Associated with Elevation in Circulating PCSK9 Levels in Cardiac Transplant Patients. AU - Simha, Vinaya. AU - Qin, Sisi. AU - Shah, Pankaj. AU - Smith, Byron H.. AU - Kremers, Walter K. AU - Kushwaha, Sudhir. AU - Wang, Liewei M. AU - Pereira, Naveen Luke. PY - 2016/12/27. Y1 - 2016/12/27. N2 - Sirolimus used in transplantation is often associated with hypercholesterolemia. We measured serum lipid and PCSK9 levels in 51 heart transplant recipients who had their immunosuppressive therapy switched from calcineurin inhibitors to sirolimus. The switch resulted in a 23% increase in LDL cholesterol, and 46% increase in triglycerides and PCSK9 levels increased from 316 ± 105 ng/mL to 343 ± 107 ng/mL (p = 0.04), however the change in PCSK9 levels did not correlate with an increase in lipid levels (p = 0.2). To investigate the mechanism for the variability in the change in PCSK9 levels, lymphoblastoid cell lines were incubated with both sirolimus and everolimus, ...
TY - JOUR. T1 - Increased immunoreactive endothelin-1 in human transplant coronary artery disease. AU - Ravalli, Stefano. AU - Szabolcs, Matthias. AU - Albala, Arline. AU - Michler, Robert E.. AU - Cannon, Paul J.. PY - 1996/1/1. Y1 - 1996/1/1. N2 - Background: The pathogenesis of transplant coronary artery disease (TCAD) is unknown, but it is thought to derive from an interaction between immune and nonimmune factors, leading to smooth muscle cell proliferation and accumulation in the expanded neointima. Endothelin-1 (ET-1), a potent vasoconstrictor with mitogenic properties for vascular smooth muscle cells, has recently been demonstrated in native vessel atherosclerosis. The present study used immunohistochemistry to investigate the role of ET-1 in TCAD. Methods and Results: ET-1 immunoreactivity and cellular localization were assessed in human coronary arteries with TCAD (n=13) and in normal coronary arteries (n=10) with single- and double-label immunohistochemistry. The intensity of ...
Background Hypercholesterolemia is common after heart transplantation and is seen in 60-80% of all patients. HMGCo-A Reductase Inhibitor (Statin) therapy is effective in cholesterol lowering and has been associated with a significant survival benefit and reduction in transplant coronary artery disease (TCAD) following heart transplantation. TCAD is seen in approximately half of heart transplant patients within 5 years and is the major limiting factor in long-term survival. In the general population hypercholesterolemia is associated with increase incident of cardiovascular mortality. It is not known if hypercholesterolemia refractory to statin therapy also has poor outcome in heart transplant recipients. ...
The purpose of this pilot trial, Transitioning to Adult Care (TRANSIT), is to develop and test an intervention (i.e., a standardized, tailored transition program focused on enhancing adherence) to improve outcomes for emerging adults who underwent heart transplantation as children and transfer to adult care. Trial Website:
Pediatric Heart Transplants Stephanie Wood ITT Technical Institute Breckinridge School of Nursing Professor M. Siddique GS1145 Pediatric Heart Transplants
Heart transplantation offers a means to improve longevity and quality of life in patients with end stage heart failure. Although survival following cardiac transplantation improved significantly following the advent of calcineurin inhibitors, the development of vascular disease within the arterial system of the grafted heart, known as cardiac allograft vasculopathy, is a major cause of morbidity and mortality (1,2). Graft vasculopathy, defined by an angiographically determined stenosis ,50% in an epicardial coronary artery, is present in 40% to 50% of patients by 5 years post-transplant and is the leading cause of death in recipients who survive past the first year (3,4). Unfortunately, ischemic symptoms in cardiac transplant patients are often nonspecific, and a common presentation of cardiac allograft vasculopathy is that of sudden cardiac death. Indeed, far too often, transplant cardiologists receive the most dreaded of phone calls from a bereaved spouse, child, or parent reporting the sudden ...
Raj govt hospital makes history by successful heart transplant: SMS Hospital in Jaipur became the first government hospital of the state to undertake a successful heart transplantation. . Get all latest entertainment & viral stories on
TY - JOUR. T1 - Revascularization procedures in patients with transplant coronary artery disease. AU - Patel, V. S.. AU - Radovancevic, B.. AU - Springer, W.. AU - Frazier, O. H.. AU - Massin, E.. AU - Benrey, J.. AU - Kadipasaoglu, K.. AU - Cooley, D. A.. PY - 1997/7/3. Y1 - 1997/7/3. N2 - Objective: To assess the efficacy of revascularization in cardiac transplant patients who developed de novo coronary artery disease. Methods: Eighteen patients underwent one or more of four methods of revascularization percutaneous transluminal coronary angioplasty (PTCA), percutaneous transluminal coronary rotational atherectomy (PTCRA), coronary artery bypass grafting (CABG), and transmyocardial laser revascularization (TMLR). Eleven PTCA procedures were performed in 10 patients 55.3 ± 6.6 months after transplantation. Six patients underwent PTCRA 83.3 ± 11.2 months after transplantation. Five patients underwent CABG 54.0 ± 12.6 months after transplantation: the mean left ventricular ejection fraction ...
Lerner DL, Chapman Q, Green KG, Saffitz JE. Reversible down-regulation of connexin43 expression in acute cardiac allograft rejection. J Heart Lung Transplant. 2001 Jan; 20(1):93-7 ...
BACKGROUND--Failure of the donor (graft) heart is the main cause of mortality in the first month after orthotopic cardiac transplantation. In a preliminary study marked downregulation of cardiac beta adrenoceptor density was found in apparently normal donor hearts of recipients who developed severe cardiac failure soon after implantation. Cardiac beta adrenoceptors are an important factor in the development of cardiac failure in the human heart. The aim of this study therefore was to determine whether fatal graft failure in the first month after transplantation is associated with downregulation of beta adrenoceptor density in the donor heart. PATIENTS AND METHODS--Right ventricular endomyocardial biopsy specimens were taken from consecutive adult donor patients immediately before implantation. A previously described radioligand binding method was used to determine beta adrenoceptor density in consecutive patients who developed fatal graft failure and died within 1 month of transplantation and in ...
TY - JOUR. T1 - Heterotopic heart transplantation. T2 - The United States experience. AU - Jahanyar, Jama. AU - Koerner, Michael M.. AU - Ghodsizad, Ali. AU - Loebe, Matthias. AU - Noon, George P.. PY - 2014/6. Y1 - 2014/6. N2 - Introduction: More than 3 decades have passed since the first heterotopic heart transplantation (HHT) was reported. Nowadays, this surgical technique is used rarely, and only in patients who do not qualify for standard orthotopic heart transplantation (OHT). Current indications mainly comprise refractory pulmonary hypertension and a donor-recipient size mismatch (,20%). The objective of this study was to analyze the United States experience with HHT. Patients and Methods: The United Network for Organ Sharing (UNOS) database between 1987 and 2007 was analyzed. Patients who underwent heart transplantation were enrolled in this study. Patients with missing transplant dates or history of retransplantation were excluded. Results: A total of 41,379 patients underwent OHT and ...
A patient with history of orthotopic heart transplant, followed by tricuspid valve replacement, and two subsequent balloon valvuloplasties was offered transcatheter tricuspid valve replacement to avoid what would have been his fourth sternotomy.
TY - JOUR. T1 - Outcomes after heart transplantation in sensitized patients bridged with ventricular assist devices. AU - Fraser, Charles D.. AU - Zhou, Xun. AU - Magruder, J. Trent. AU - Suarez-Pierre, Alejandro. AU - Lui, Cecillia. AU - Grimm, Joshua C.. AU - Higgins, Robert. AU - Kilic, Ahmet. PY - 2019/6/1. Y1 - 2019/6/1. N2 - Objective: Sensitization has been associated with worse outcomes following heart transplantation (HTx). The use of ventricular assist devices (VAD) is a risk factor for the development of sensitization. We investigated the impact of left ventricular assist devices (LVAD) and sensitization in HTx recipients. Methods: We queried the UNOS database for all heart transplants performed from January 2000 through December 2016. Patients were considered highly sensitized and included if panel-reactive antibody (PRA) activity was 25% or higher. Patients were separated by pretransplant LVAD utilization and subgroup analysis was performed by device type (HeartMate II or ...
Pre-operative Risk Factors and Clinical Outcomes Associated with Vasoplegia in Recipients of Orthotopic Heart Transplantation in the Contemporary Era. Writer and Curator: Larry H. Bernstein, MD, FCAP and Curator: Aviva Lev-Ari, PhD, RN Patarroyo M, Simbaqueba C, Shrestha K, Starling RC, Smedira N, Tang WH, Taylor DO. J Heart Lung Transplant. 2012 Mar;31(3):282-7. Epub…
TY - JOUR. T1 - Duration of Left Ventricular Assist Device Support Does Not Impact Survival After US Heart Transplantation. AU - Grimm, Joshua C.. AU - Magruder, J. Trent. AU - Crawford, Todd C.. AU - Fraser, Charles D.. AU - Plum, William G.. AU - Sciortino, Christopher M.. AU - Higgins, Robert. AU - Whitman, Glenn. AU - Shah, Ashish S.. PY - 2016/10/1. Y1 - 2016/10/1. N2 - Background The aim of this study was to determine whether the duration of left ventricular device support (LVAD) influenced outcomes after orthotopic heart transplantation in a modern, bridge to transplant national cohort. Methods The United Network for Organ Sharing database, which has recently made pretransplant LVAD duration available, was queried for all adult bridge to transplant patients between January 2011 and December 2012. Three LVAD duration cohorts were generated, as follows: short (less than 90 days), intermediate (90 to 365 days), and prolonged (more than 365 days). Recipient, donor, and transplant-specific ...
Background. Selected patients with cardiac sarcoidosis undergo heart transplantation, but outcomes may be adversely affected by recurrent cardiac sarcoidosis or progressive extra-cardiac sarcoidosis. Objectives. We present our single-center experience of patients with cardiac sarcoidosis who underwent heart transplantation.. Methods. Consecutive patients that underwent heart transplantation between 1990 and 2012 were assessed. Cardiac sarcoidosis was defined by the presence of multiple non-caseating epithelioid cell granulomata in the explanted heart. Baseline characteristics and clinical outcomes were compared with a control group without cardiac sarcoidosis that underwent heart transplantation during this period.. Results. 901 patients underwent heart transplantation during the study period, of whom 4 patients had a pre-transplant diagnosis of cardiac sarcoidosis and 8 patients had sarcoidosis identified in the explanted heart. Patients with cardiac sarcoidosis had excellent post-transplant ...
Semantic Scholar extracted view of Prolongation of allograft survival in rat heterotopic heart transplantation by TLCK, a serine protease inhibitor. by Paul Morrissey et al.
Patients with CSA who subsequently underwent successful heart transplantation were re-evaluated for the presence of sleep-disordered breathing (SDB) at a minimum of 6 months after transplantation. A group of patients with severe CHF and no SDB who also underwent successful heart transplantation with repeat overnight polysomnography at a minimum of 6 months after transplantation and were matched for posttransplant medical therapy, served as a control group. All patients were in stable condition and had maintained normal function of the heart allograft. The study was approved by the Alfred Hospital Ethics Committee, and all patients provided written informed consent ...
TY - JOUR. T1 - Interaction between rapamycin and pretransplant blood transfusions in rat heterotopic heart transplantation. AU - Tucker, M. J.. AU - Duplan, J.. AU - Li, Xian Chang. AU - Garcia, B.. AU - Wijsman, J.. AU - Stiller, C.. AU - McKenzie, F. N.. PY - 1993/1/1. Y1 - 1993/1/1. UR - UR - M3 - Article. C2 - 8438458. AN - SCOPUS:0027418974. VL - 25. SP - 725. EP - 726. JO - Transplantation Proceedings. JF - Transplantation Proceedings. SN - 0041-1345. IS - 1. ER - ...
TY - JOUR. T1 - Infections in mortally ill cardiac transplant recipients. AU - Hsu, J.. AU - Griffith, B. P.. AU - Dowling, Robert. AU - Kormos, R. L.. AU - Dummer, J. S.. AU - Armitage, J. M.. AU - Zenati, M.. AU - Hardesty, R. L.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - A total of 351 cardiac transplantations performed between June 1, 1980, and Sept. 30, 1987, were reviewed to determine if infectious complications were more frequent in those patients requiring preoperative intravenous inotropic support, placement of an intraaortic balloon pump, or mechanical support with a left ventricular assist device or total artificial heart. One hundred forty-nine transplants (45%) were performed in these mortally ill patients. There was no statistically significant difference between patients with and without infection within each support group for the following: the number of in-patient days awaiting a donor heart, the number of days receiving support, the percent of patients with preoperative tracheal ...
A 60-year-old man with end-stage heart failure underwent orthotopic heart transplantation. Before transplantation, he had elevated pulmonary artery (PA) pressures (60/17 mm Hg, mean PA 35 mm Hg) and pulmonary vascular resistance (PVR) (6.6 Wood units).. Following transplantation, he initially did well, with normalization of PA pressures (27/13 mm Hg, mean PA 20 mm Hg). Several months later, however, he developed overt right heart failure. Invasive hemodynamic evaluation demonstrated severe pulmonary hypertension (92/51 mm Hg, mean PA 66 mm Hg) with a PVR of 10 Wood units. There was no evidence of allograft rejection or pulmonary embolism. Transthoracic echocardiogram demonstrated right ventricular (RV) systolic dysfunction and enlargement. Color flow Doppler imaging demonstrated continuous flow from the ascending aorta into the main PA. The anatomy was confirmed by computed tomographic angiographic imaging (Fig. 1). ...
Гистологические и плазменные изменения после гетеротопической трансплантации сердцаHistological features and blood plasma changes after heterotopic heart transplantation
The Pediatric Heart Transplant Program is one of the most active in the United States with 75% of referrals coming from outside the metropolitan St. Louis area. Since the program began in 1986, more than 380 patients - ranging in age from 3 days to 22 years - have received heart transplants.. The most common reasons for heart transplantation in pediatric patients are congenital heart defects and cardiomyopathy, which once robbed infants and children of life. Defects such as hypoplastic left heart syndrome now are routinely treated through heart transplantation. Washington University pediatric cardiothoracic surgeons at St. Louis Childrens Hospital, who first offered transplant as a treatment alternative for hypoplastic left heart syndrome in 1989, have performed more than 55 transplants for the defect. After transplant, both infants and older pediatric patients exhibit normal developmental levels for their ages. Most children attend school and participate in a variety of normal childhood ...
heart transplant diagram dr jadhav is authorised surgeon to do heart transplant in maharashtra by zonal transplant committee heart transplant diagram showing the recipients superior and inferior vena cava and the donor heart transplant easy way to see how its sutured in heart transplant no description yet heart section through the middle organ donationorgan donation supplies organs such as hearts to those in need of an organ transplant a heart transplant is a heart transplantg heart title heart transplant heartdiagramg the syncardia total artificial heart heart transplant diagram showing the transplanted heart with sutures heart surgery india india surgery heart transplant india best india surgery price heart picture of the heart and great vessels in heart transplant surgeons last month performed a heterotopic or piggyback heart transplant that involves connecting a donors heart to the patients heart as shown in the .
Heart-transplant recipients treated with the HMG-CoA reductase inhibitor pravastatin generally show higher plasma concentrations of this drug than control subjects. However, our data suggest that the HMG-CoA reductase inhibitor pravastatin can be used effectively in these patients receiving the immu …
TY - JOUR. T1 - Heart transplantation in females. T2 - the experience in Puerto Rico.. AU - Banchs, Hector L.. AU - González, Velda. AU - González Cancel, Iván. AU - Quintana, Cid. AU - Calderón, Rafael. AU - Altieri, Pablo I.. PY - 2005. Y1 - 2005. N2 - BACKGROUND: Heart transplantation is the procedure of choice for a selected group of patients with end stage heart disease. Gender related differences have been observed in the heart transplant field: less women than men are recipients of heart transplants, more risk of rejection in female recipients, and a perception toward reduced survival in women. We report our experience of heart transplantation in females in Puerto Rico. METHODS: We studied the data bank of 69 heart transplant recipients in the Puerto Rico Heart Transplant Program from June 1999 to June 2005. Gender related differences in the number of recipients: males or females, incidence of rejection, survival, and other outcomes were analyzed. RESULTS: 69 patients received an ...
Approximately two-thirds of patients implanted with ventricular assist devices recover sufficiently to requalify for heart transplantation, and the other one-third die of complications that are often secondary to delayed ventricular assist device implantation and subsequent end-organ failure. To determine whether any preoperative predictors of survival exist, univariate statistics and multivariate stepwise logistic regression analysis were performed on pre-ventricular assist device demographics, hemodynamics, and blood chemistry in 186 patients receiving Thoratec ventricular assist devices (Thoratec Laboratories Corp., Berkeley, Calif.) while awaiting transplantation. The duration of circulatory support averaged 19.6 days (maximum, 226 days). One hundred thirty-seven patients (74%) received biventricular support, 47 received isolated left ventricular assist devices, and two received right ventricular assist devices. The average blood flow was 5.0 +/- 0.9 L/min. One hundred eighteen patients (63%)
End-stage heart failure is associated with significant morbidity and mortality. Heart transplantation has the potential to offer a return to daily activities for critically ill patients and is the gold standard therapy. However, heart transplantations are decreasing yearly with a historic low in Germany in 2017. By striking contrast, both waiting list numbers and waiting time have increased owing to a lack of acceptable donor organs. Ventricular assist devices (VAD) represent a reasonable therapeutic alternative for patients on heart transplantation waiting lists. Patients ineligible for transplantation may undergo VAD implantation as a destination therapy. However, the necessity for life-long anticoagulation must be weighed against bleeding complications in potential VAD candidates. VAD-dependent patients also face risks of driveline infections, in addition to restricted activities of daily living owing to limited battery capacities. Given Germanys low transplantation rate, VAD implantation ...
1. Although the high-frequency fluctuations in R-R interval (respiratory sinus arrhythmia) observed in heart transplant recipients are not a reliable marker of reinnervation because of a previously shown direct mechanical effect of breathing, the presence of a non-respiration-related low-frequency oscillation reflects rhythms generated outside the heart, and thus could be neurally mediated.. 2. To evaluate the presence of reinnervation, the spontaneous variability in R-R interval was investigated, supine and after passive tilting, in 23 heart transplant recipients (age 43 years, range 23-64 years) and in 25 normotensive control subjects by autoregressive spectral analysis of low- and high-frequency spontaneous fluctuations in R-R interval and respiration. The response of R-R interval to amyl nitrite inhalation was also evaluated in five heart transplant recipients and eight control subjects.. 3. Detectable low-frequency oscillations, unrelated to respiration, were present in 13/23 heart ...
TY - JOUR. T1 - Adenovirus infections in heart transplantation. AU - Florescu, Diana F.. AU - Kwon, Joong Y.. AU - Dumitru, Ioana. PY - 2013/7. Y1 - 2013/7. N2 - Adenovirus infections have been associated with significant morbidity and mortality in immunocompromised hosts. The clinical significance of adenovirus disease in heart transplantation is not well-defined; in particular, the significance of adenovirus identification in myocardium remains unclear. Although severe adenovirus disease has been described in heart transplant recipients, adenovirus infections seem to be more frequently associated with increased risk of adverse cardiac events, such as rejection, ventricular dysfunction, coronary vasculopathy, need for retransplantation, and graft loss because of death. Cidofovir is currently considered the standard of treatment for adenovirus disease not responding to reduction of immunosuppression.. AB - Adenovirus infections have been associated with significant morbidity and mortality in ...
The pediatric heart transplant program at Monroe Carell Jr. Childrens Hospital at Vanderbilt offers children with end-stage heart problems a chance to be a kid again.
Heart transplantation (HT) is an acceptable method of treating severe heart diseases in children when all other options have been exhausted. It is primarily intended for children suffering from cardiomyopathies, less often for children with severe arrhythmias and congenital heart defects. This method of treating children requires a multidisciplinary specialist cooperation and support in the childs home surroundings. Goal: The main goal is to present the development of Croatian paediatric transplantation cardiology. The secondary goal is to raise awareness of heart transplantations in children in order to motivate organ donations, it being the most limiting factor of the method. Results of study: The first heart transplantation in a child in Croatia was performed in 2011. Transplantation preparations were performed in eleven children. Two of the children died while on the waiting list, one child was removed from the waiting list due to recovery, and in eight of the children a transplantation was ...
Compared to other heart transplant recipients, Black patients had an overall 30% higher risk of death after their transplant. But the risk of death was two times higher among Black patients aged 18 to 30 and 1.5 times higher among those aged 31 to 40.. Among the youngest Black patients, the risk of death was greatest during the first year after transplant, with a nearly 2.3 times higher risk of death in this time period, according to the study published Feb. 2 in the journal Circulation: Heart Failure. After age 61, there was no significant racial disparity in outcomes among heart transplantation recipients.. Our study is the first to highlight young Black recipients as a subgroup at a higher risk of death during the first year after a heart transplant, said study first author Dr. Hasina Maredia, who led the project as a medical student at Johns Hopkins University in Baltimore.. Our findings indicate clinical research moving forward should focus attention on young Black recipients during this ...
The impact of a defensive response set on the relationship between MMPI and cognitive tests among heart transplant candidates ...
Accelerated coronary artery disease is a major cause of mortality in heart transplant recipients; however, it does not appear to play a major role in the clinical outcome of heart-lung transplant recipients. The purpose of this study was to determine whether the incidence and severity of transplant coronary artery disease as detected by intracoronary ultrasound in heart-lung transplant recipients are less than those encountered in heart transplant recipients.We studied the left anterior descending coronary artery with the use of intracoronary ultrasound imaging in 22 heart-lung transplant recipients at the time of their routine annual coronary angiogram. Twenty-two heart transplant recipients were case matched for number of years after transplant at ultrasound study, recipient age, donor age, and diagnosis of nonischemic cardiomyopathy. Mean intimal area, intimal index, Stanford class, and incidence of at least moderate disease (Stanford class , or = 3) were measured and calculated in each group ...
Abstract T-cell or natural killer (NK)-cell posttransplant lymphoproliferative disorder (T-PTLD) is a rare but severe complication after transplantation. Here we present the clinicopathological features of a single center series of 9 cases. Additionally, we summarize the clinicopathological findings of 147 T/NK-cell PTLDs reported in the literature in an attempt to define subtype-specific characteristics. T/NK-cell PTLD occurs in patients of all ages, usually extranodally, and most frequently after kidney transplantation. Organ specific incidence however is highest following heart transplantation. Approximately one third of T-cell PTLDs are Epstein-Barr virus (EBV)-related, with peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) being the most prevalent EBV-associated T-cell PTLD. A male predominance was observed, which is most striking in the EBV (+) group, particularly in PTCL, NOS. With a median posttransplantation interval of 72 months T-cell PTLDs are among the late occurring ...
TY - JOUR. T1 - Renal injury and recovery in pediatric patients after ventricular assist device implantation and cardiac transplant. AU - Hollander, Seth A.. AU - Cantor, Ryan S.. AU - Sutherland, Scott M.. AU - Koehl, Devin A.. AU - Pruitt, Elizabeth. AU - McDonald, Nancy. AU - Kirklin, James K.. AU - Ravekes, William J.. AU - Ameduri, Rebecca. AU - Chrisant, Maryanne. AU - Hoffman, Timothy M.. AU - Lytrivi, Irene D.. AU - Conway, Jennifer. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background: The use of ventricular assist devices (VADs) in children with heart failure may be of particular benefit to those with accompanying renal failure, as improved renal function is seen in some, but not all recipients. We hypothesized that persistent renal dysfunction at 7 days and/or 1 month after VAD implantation would predict chronic kidney disease (CKD) 1 year after heart transplantation (HT). Methods: Linkage analysis of all VAD patients enrolled in both the PEDIMACS and PHTS registries between 2012 and 2016. ...
BACKGROUND: Post-transplant malignancy (PTM) is a major cause of morbidity and mortality following heart transplantation. Human leukocyte antigen-G (HLA-G) is an immune checkpoint molecule which functions to dampen the immune response. HLA-G expression was initially thought to be restricted to cytotrophoblast cells, where it was shown to confer protection to the semi-allograft fetus from the maternal immune system. Since its discovery, HLA-G has been implicated as an important mediator in a variety of pathological situations, such as transplantation and cancer. Literature suggests high HLA-G expression is beneficial in reducing acute rejection by dampening the host immune response against the allograft. However, this same level of expression may be detrimental in the context of cancer; post-transplant HLA-G expression may be utilized by malignant cells as an escape mechanism to evade the host immune system and promote cancer development. Interestingly, recent evidence suggests HLA-G expression ...
OBJECTIVES: To evaluate the value of cardiac power output index (CPOi) in predicting severe primary graft dysfunction (PGD) after heart transplantation (defined as mechanical circulatory support [MCS] and/or mortality ,30 days after transplant).. DESIGN: Observational cohort study.. SETTING: A heart transplant center in the United Kingdom.. PARTICIPANTS: Consecutive patients who underwent heart transplantation from January 2014 to December 2019 (n = 160). Twenty patients were excluded, as MCS was instituted immediately after transplant.. INTERVENTIONS: None.. MEASUREMENTS AND MAIN RESULTS: Hemodynamic data on return to the intensive care unit (time 0, T0) and at 6 hours (T6) were collected to calculate CPOi at both points in 140 consecutive patients-22 patients developed severe PGD. The CPOi at T0 correlated with donor-recipient predicted heart mass and inversely with inotrope score. Patients who developed severe PGD had significantly lower CPOi at T0 and T6. The areas under the receiver ...
Foxp3 stability of vitamin C-treated induced-regulatory T cells (V-iTregs) is superior to that of conventional iTregs (C-iTregs). However, the role of V-iTregs in allograft rejection under vitamin C-deficient conditions, such as those seen in humans, remains unclear. We aimed to elucidate the role of vitamin C treatment on generation and maintenance of iTregs from gulo knockout (Gulo-KO) mice as well as wild type (WT) mice, and in vitro and in vivo suppressive effects of V-iTregs on heart allograft rejection in either Gulo-KO or WT recipient mice. Conversion efficiency of iTregs was similar between C- and V-iTregs in both WT and Gulo-KO mice. V-iTregs from WT or Gulo-KO mice showed better in vitro Foxp3 stability than C-iTregs, although there was no difference between WT V-iTregs and Gulo-KO V-iTregs. Furthermore, V-iTregs from WT or Gulo-KO mice suppressed in vitro T cell proliferation better than C-iTregs. Heterotrophic heart transplantation from BALB/c mice to WT or vitamin C-deficient ...
BACKGROUND Although many risk factors are reported about graft rejection after heart transplantation (HTx), the effect of HLA mismatch (MM) still remains unknown, especially in the Japanese population. The aim of the present study was to investigate the influence of HLA MM on graft rejection among HTx recipients in Japan. METHODS We retrospectively investigated the association of the number of HLA MM including class I (A, B) and class II (DR) (for each locus MM: 0 to 2, total MM: 0 to 6) and the incidence of moderate to severe acute cellular rejection (ACR) confirmed by endomyocardial biopsy (International Society for Heart and Lung Transplantation grade ≥ 3A/2R) within 1 year after HTx. RESULTS Between 2007 and 2014, we had 49 HTx cases in our institute. After excluding those with insufficient data and positive donor-specific antigen, finally 35 patients were enrolled. Moderate to severe ACR was observed in 16 (45.7%) patients. The number of HLA-DR MM was significantly associated with the
[Medicine]. [Heart Transplantation]. Christiaan Barnard et al. Human Heart Transplantation.In South African Medical - Available at 2020 March 4 Rare Books...
International Society for Heart and Lung Transplantation (ISHLT)". European Heart Journal. 37 (1): 67-119. doi:10.1093/ ... "National Heart, Lung, and Blood Institute.. *^ a b c d e f g Frank Gaillard. "Pulmonary hypertension". Radiopaedia. Retrieved ... endorsed by the International Society of Heart and Lung Transplantation (ISHLT)". European Heart Journal. 30 (20): 2493-537. ... The Journal of Heart and Lung Transplantation. 31 (9): 913-33. doi:10.1016/j.healun.2012.06.002. PMID 22884380.. ...
a b c ABO Incompatible Heart Transplantation in Young Infants. (2009, July 30). ABO Incompatible Heart Transplantation in Young ... West, L. J. (2011). "ABO-incompatible hearts for infant transplantation". Current Opinion in Organ Transplantation. 16 (5): 548 ... "Intentional ABO-incompatible heart transplantation: a case report of 2 adult patients". The Journal of Heart and Lung ... "Current status of paediatric heart, lung, and heart-lung transplantation". Archives of Disease in Childhood. 89 (4): 386-389. ...
"The Journal of Heart and Lung Transplantation. 34 (11): 1366-1375. doi:10.1016/j.healun.2015.05.025. PMID 26210752.. ... and heart failure.[2] Use during pregnancy may result in harm to the baby.[2] Imatinib works by stopping the Bcr-Abl tyrosine- ...
The success of Blaiberg's heart transplant furthered the progress made in regard to heart transplantation. Blaiberg was born in ... "Heart Transplantation". Salem Press. Archived from the original on 25 March 2006. Retrieved 8 February 2007. CS1 maint: ... In March 1967, Blaiberg's heart failed, and it appeared that he was dying. The world's first human heart transplant operation ... By the end of August 1968, 34 heart transplants had been performed, and by December 1968, 100 hearts had been transplanted into ...
"Cause of atrioventricular block in patients after heart transplantation". Transplantation journal. "USC AGSA Dinner Dance and ... "Cause of Atrioventricular Block in Patients After Heart Transplantation.". Margarian continued his education at the USC ... He co-authored a research article in the peer-reviewed journal Transplantation on " ...
Human heart transplantation: current status. Annals of Thoracic Surgery. 1976 August; 22(2): 171-175. PMID 788661 Griepp RB, ... Children's Heart Fund Precious Heart Award, 2003 Distinguished Scientist Award, Bicuspid Aortic Foundation Partial list: Etz CD ... A heart and lung transplant program commenced in 1990. Griepp stepped down as chairman in 2001 to pursue research and clinical ... He has received nearly $8 million in grants from the National Heart, Lung, and Blood Institute todate. He is currently a ...
Heart transplantation in Chagas' disease. 10 years after the initial experience. Circulation. 1996 Oct 15;94(8):1815-7. PMID ... He is internationally known for performing the first heart transplantation in Latin America (and the third in the world) in ... Experience on three cases of human heart transplantation. Laval Med. 1970 Feb;41(2):149-54. PMID 4929483 Losardo RJ et al. ... Alfonso Roque Albanese: Latin American Pioneer of Heart Surgery. Tribute from the Pan American Association of Anatomy. Int. J. ...
In 1984, it began covering heart transplantations offered at Stanford University Medical Center. The Blue Cross of California, ... Evans, Roger W. (January 1987). "The economics of heart transplantation". Circulation. 75 (1): 73. doi:10.1161/01.CIR.75.1.63 ...
It also includes heart transplantation. The earliest operations on the pericardium (the sac that surrounds the heart) took ... "Heart Surgery , National Heart, Lung, and Blood Institute (NHLBI)". "A Heart Surgery Overview - Texas Heart Institute". www. ... Norman Shumway is widely regarded as the father of human heart transplantation, although the world's first adult heart ... Recovery from open-heart surgery begins with about 48 hours in an intensive care unit, where heart rate, blood pressure, and ...
... and three-year experience in heart transplantation. The Journal of Heart and Lung Transplantation. 1994, 13 (4): 571-82. PMID ... Mycophenolate mofetil versus azathioprine for prevention of ac而ute rejection in renal transplantation (MYSS): a randomised ... Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF).. Clinical Transplantation. 1996, 10 (1 Pt 2): ... a review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in renal transplantation." Drugs. 1996, 51 ...
"Relation between norman and heart transplantation". Cite journal requires ,journal= (help) "Norman Shumway, Heart ... International Recognition Award, Heart Research Foundation, 1982. Gold Heart Award, American Heart Association, for ... The couple had four children, one of whom directs heart and lung transplantation at the University of Minnesota. Shumway died ... The Newsletter of the International Society for Heart and Lung Transplantation, Volume 1, Issue 1,, Summer 1998 ...
... a pioneer in human heart transplantation; in 1987 he performed the first successful heart transplant in Poland; in 1995 he was ... Blue laser - first blue laser in Poland (third in the world) Artificial heart - an implant, program: "Polish Artificial Heart" ... a renowned Polish transplantation surgeon and scientist who gained world recognition when she led a team of eight surgeons ... in 2004 Religa and his team developed an implantable pump for a pneumatic heart assistance system Maria Siemionow, ...
Heart Transplantation Geneva, Switzerland, 1968 III. Evaluation of Drugs: Whose Responsibility? Liège, Belgium, 1968 IV. ...
Current Advances in Heart Transplantation: An Issue of Heart Failure Clinics, Elsevier (2007), ISBN 978-1416043201. History of ... the Journal of Heart and Lung Transplantation. He was also president of the Heart Failure Society of America. Mandeep Rajinder ... the Journal of Heart and Lung Transplantation. In 2016, he was appointed president of the Heart Failure Society of America. He ... Journal of Heart and Lung Transplantation. Retrieved June 6, 2015. Stiles, Steve (February 1, 2012). "Dr Mandeep Mehra leaves ...
A Jarvic 7 heart was used as a bridge to transplantation until a human donor heart could be found and the patient subsequently ... "International Society For Heart & Lung Transplantation Reveals 2014 Award Winners" (PDF). International Society for Heart & ... Three months after the moratorium on heart transplantation, English became inspired by a visit to his friend Philip Caves, at ... A founding member of the International Society for Heart Transplantation, English subsequently received the Society's Lifetime ...
"What's old is new again: Palliative Potts shunt in children with PAH". International Society for Heart & Lung Transplantation. ... Open heart surgery had become common by this time, and Potts said that it should be performed "by young men whose fingers are ... Potts' congenital heart surgery research center was renamed in his honor. In a 1966 interview with the Associated Press, Potts ... Potts' work with heart surgery included the invention of at least three surgical devices. His neighbor, Bruno Richter, worked ...
... primarily for detecting rejection of a donor heart following heart transplantation. It is also used as a diagnostic tool in ... The main reason for performing an EMB is to assess allograft rejection following heart transplantation and sometimes to ... ISBN 978-0-7817-5567-2. Hunt, Sharon (19 August 2008). "The Changing Face of Heart Transplantation". Journal of the American ... Unlike for rejection detection, for diagnosing heart disease, different biopsy sites within the heart are targeted. It is ...
A cytokine-responsive macrophage molecule expressed in transplanted human hearts". Transplantation. 61 (9): 1387-92. doi: ...
When heart transplantation is required in a person with situs inversus, reconstruction of the venous pathways to accommodate a ... Eddy, S. "Dextrocardia and Proper Lead Placement". Deuse, Tobias; Reitz, Bruce A. (September 2009). "Heart-Lung Transplantation ... In this form of dextrocardia, the heart is simply placed further right in the thorax than is normal. It is commonly associated ... Dextrocardia with situs inversus refers to the heart being a mirror image situated on the right side. For all visceral organs ...
... a dilemma for lung transplantation". The Journal of Heart and Lung Transplantation. 22 (2): 210-3. doi:10.1016/S1053-2498(02) ... "Sirolimus-associated interstitial pneumonitis in 3 heart transplant recipients". The Journal of Heart and Lung Transplantation ... The Journal of Heart and Lung Transplantation. 26 (3): 296-8. doi:10.1016/j.healun.2006.12.004. PMID 17346635. Delgado JF, ... Mukherjee S, Mukherjee U (1 January 2009). "A comprehensive review of immunosuppression used for liver transplantation". ...
The Journal of Heart and Lung Transplantation. 29 (5): 509-516. doi:10.1016/j.healun.2009.11.602. PMID 20061166. Sombogaard F, ... 2008). "Association of four DNA polymorphisms with acute rejection after kidney transplantation". Transpl. Int. 21 (9): 879-91 ... 2010). "Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients". ... a 2-year follow-up in kidney transplantation". Clin. Pharmacol. Ther. 83 (2): 328-35. doi:10.1038/sj.clpt.6100300. PMID ...
Matsuura K, Haraguchi Y, Shimizu T, Okano T (2013). "Cell sheet transplantation for heart tissue repair". J Control Release. ... Mammal hearts also host naturally occurring cardiac stem cells which may be capable of differentiating themselves into ... Cardiomyoplasty is a surgical procedure in which healthy muscle from another part of the body is wrapped around the heart to ... heart muscle). Tissue engineering, which is now being categorized as a form of regenerative medicine, can be defined as ...
The Journal of Heart and Lung Transplantation. 27 (4): 457-61. doi:10.1016/j.healun.2008.01.013. PMID 18374884. Basic & ... heart arrhythmia - decrease the output of sinus node thus stabilizing heart function coronary artery disease - reduce heart ... Ørn S, Dickstein K (2002-04-01). "How do heart failure patients die?". European Heart Journal Supplements. 4 (Suppl D): D59-D65 ... This response dilates pupils, increases heart rate, mobilizes energy, and diverts blood flow from non-essential organs to ...
The Journal of Heart and Lung Transplantation. 21 (10): 1131-4. doi:10.1016/s1053-2498(02)00404-7. PMID 12398880. Athar MA, ...
He would ultimately perform more than 400 heart transplantations and thousands of heart operations in his lifetime, keeping in ... He gave yearly talks at the French-speaking meeting "Journées de La Pitié" which focuses on heart transplantation and ... Cabrol was involved with the International Society for Heart and Lung Transplantation (ISHLT) from its inception in 1981. In ... He was in addition, appointed honorary president of the European Society of Heart Transplantation and president of the ...
The Journal of Heart and Lung Transplantation published updated guidelines in 2001 for grading the severity of BOS. The ... The Journal of Heart and Lung Transplantation. 21 (3): 297-310. doi:10.1016/S1053-2498(02)00398-4. PMID 11897517. Au BK, Au MA ... The Journal of Heart and Lung Transplantation. 21 (3): 297-310. doi:10.1016/S1053-2498(02)00398-4. PMID 11897517. King MS, ... guidelines and classification system were published in 1993 by the International Society for Heart and Lung Transplantation. ...
The Journal of Heart and Lung Transplantation. 21 (10): 1074-9. doi:10.1016/S1053-2498(02)00440-0. PMID 12398872. CD69+protein ... "Effect of mycophenolate mofetil therapy on lymphocyte activation in heart transplant recipients". ...
"Cyclosporine in heart and heart-lung transplantation". Canadian Journal of Surgery. 28 (3): 274-280, 282. PMID 3922606. ... the British pioneer in transplantation, introduced 6-MP as an experimental immunosuppressant for kidney and heart transplants. ... especially in heart-related transplantations. Moreover, despite being considerably more expensive, mycophenolate mofetil is ... In the United States, it is approved by the Food and Drug Administration for use in kidney transplantation from human donors, ...
The Journal of Heart and Lung Transplantation. 27 (4): 457-61. doi:10.1016/j.healun.2008.01.013. PMID 18374884. Davis E, ... Heart muscle contraction Increase cardiac output (minor degree compared to β1). Increases heart rate in sinoatrial node (SA ... April 2008). "Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure". ...
... and three-year experience in heart transplantation". The Journal of Heart and Lung Transplantation. 13 (4): 571-82. PMID ... They subsequently demonstrated that it was useful in organ transplantation in experimental rats. After successful clinical ... Clinical Transplantation. 10 (1 Pt 2): 77-84. PMID 8680053. Allison, AC; Eugui, EM (1993). "The design and development of an ... as well as for immune rejection in organ transplantation. He developed an idea that if a molecule that could block the enzyme ...
IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts. Cellular Physiology and Biochemistry. 2016, 38 ... American Journal of Transplantation. September 2015, 15 (9): 2431-42. PMID 25943855. doi:10.1111/ajt.13288.. ... The role of peripheral T-cell deletion in transplantation tolerance. Philosophical Transactions of the Royal Society of London ... bone marrow transplantation, and HIV-1 infection. Annual Review of Immunology. 2000, 18: 529-560. ISSN 0732-0582. PMID 10837068 ...
... including the heart, liver, and muscle, and these cells had been suggested to have the abilities of regenerating injured tissue ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... Biology of blood and marrow transplantation. American Society for Blood and Marrow Transplantation. 2 (1): 3-14. PMID 9078349. ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ...
"Heart Views. 4 (2).. copy Archived 30 November 2004 at the Wayback Machine. ... "Heart Views. 5 (2): 74-85 [80]. 2004. Archived from the original on 8 March 2013.. ... The anesthesiologist's role during surgery is to prevent derangement in the vital organs' (i.e. brain, heart, kidneys) ... that deals with pain and symptom relief and emotional support in patients with terminal illnesses including cancer and heart ...
Röntgen discovered X-rays' medical use when he made a picture of his wife's hand on a photographic plate formed due to X-rays. The photograph of his wife's hand was the first ever photograph of a human body part using X-rays. When she saw the picture, she said, "I have seen my death."[28] The first use of X-rays under clinical conditions was by John Hall-Edwards in Birmingham, England on 11 January 1896, when he radiographed a needle stuck in the hand of an associate. On 14 February 1896, Hall-Edwards also became the first to use X-rays in a surgical operation.[29] The United States saw its first medical X-ray obtained using a discharge tube of Ivan Pulyui's design. In January 1896, on reading of Röntgen's discovery, Frank Austin of Dartmouth College tested all of the discharge tubes in the physics laboratory and found that only the Pulyui tube produced X-rays. This was a result of Pulyui's inclusion of an oblique "target" of mica, used for holding samples of fluorescent material, within the ...
Liver transplantation. *Portal hypertension *Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt ...
Renal transplantation replaces kidney function by inserting into the body a healthier kidney from an organ donor and inducing ... The physical examination typically includes an assessment of volume state, blood pressure, heart, lungs, peripheral arteries, ... Nephrologists may further sub-specialise in dialysis, kidney transplantation, chronic kidney disease, cancer-related kidney ... At present, renal transplantation is the most effective treatment for end-stage kidney failure although its worldwide ...
National Heart, Lung, and Blood Institute Working Group on Restless Legs Syndrome". American family physician 62 (1): 108-14. ... Nephrology Dialysis Transplantation 21: 184-90. doi:10.1093/ndt/gfi144. ...
Liver transplantation may be a valid option if no improvement occurs.[33] ... Heart valve calcification[3]. *Hypercalcemia. *Increased intracranial pressure manifesting as cerebral edema, papilledema, and ...
By comparison, a typical heart transplant operation lasts 6 to 8 hours. Surgeons usually connect the bones first, followed by ... 2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... Hand transplantation is a surgical procedure to transplant a hand from one human to another. The "donor" hand usually comes ... On October 26, 2016, the Director of hand transplantation at UCLA, Dr. Kodi Azari, and his team,[14] performed a hand ...
Lung transplantation. Decortication of lung. Heart-lung transplant. Chest wall, pleura,. mediastinum,. and diaphragm. pleura/ ...
In its terminal state, the kidneys and the heart are affected. FAP is characterized by the systemic deposition of amyloidogenic ... The disadvantage of liver transplantation is that approximately 10% of the subjects die from the procedure or complications ... Additional testing should be performed to identify involvement of the heart or kidneys.[6] ... FAP can be ameliorated by liver transplantation. ...
Advanced COPD leads to high pressure on the lung arteries, which strains the right ventricle of the heart.[5][37][38] This ... Stopping smoking, respiratory rehabilitation, lung transplantation[2]. Medication. Vaccinations, inhaled bronchodilators and ... "U.S. National Heart Lung and Blood Institute. Archived from the original on 2012-04-27. Retrieved 2013-07-23.. ... "National Heart, Lung, and Blood Institute. July 31, 2013. Archived from the original on November 18, 2013. Retrieved November ...
Particular organ problems (e.g. diseases involving the skin, heart, facial development and skeletal system) may be present in ... Virus-specific T-Lymphocytes (VST) therapy is used for patients who have received hematopoietic stem cell transplantation that ... June 2008). "Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplant. 41 Suppl 2: S83-6. doi:10.1038/ ...
The thickening of the heart valves along with the walls of the heart can result in progressive decline in cardiac function. The ... For a long time, the most efficient approach had been to use bone marrow graft, or hematopoietic stem cell transplantation. ... Because of all these reasons, bone marrow grafts or hematopoietic stem cell transplantation have seen a decrease in their ... long term follow-up on patients undergone to hematopoietic stem cell transplantation, Minerva Pediatr. 2013 Oct;65(5):487-96. ...
Iradj Gandjbakhch (b. 1941), cardiac surgeon, performed Europe's first heart transplantation on 27 April 1968 along with Dr. ... Christian Cabrol (1925-2017), cardiac surgeon, performed Europe's first heart transplantation on 27 April 1968. ...
... reduction in death from coronary heart disease to a point where people are no more likely to die of coronary heart disease than ... April 2000). "Liver transplantation in patients with homozygotic familial hypercholesterolemia previously treated by end-to- ... Heart J. 29 (21): 2625-33. doi:10.1093/eurheartj/ehn422. PMC 2577142. PMID 18840879.. ... This may lead to angina pectoris (chest pain or tightness on exertion) or heart attacks. Less commonly, arteries of the brain ...
Joseph's Lung Transplantation Program", Accessed October 13, 2010. *^ "St. Joseph's Expects Lung Transplant Program to Nearly ... It includes the Barrow Neurological Institute, the Heart & Lung Institute, and a Level I Trauma Center verified by the American ... "Center for Thoracic Transplantation", Accessed September 24, 2010. *^ "Best Hospitals 2009 Specialty Search: Neurology and ... The program is offered through the Center of Thoracic Transplantation and has received accreditation from the Centers for ...
... the first pediatric heart transplant in the state in 1987, and the first triple organ transplant of heart, lungs and liver in ... Vanderbilt also offers an organ transplantation center. Vanderbilt's first kidney transplant was in 1962; since then there have ... Vanderbilt Heart & Vascular Institute. VUMC also has hospitals, clinics, physician practices and affiliates covering nine ... VUMC has also had more than 2000 liver transplants and 600 heart and lung transplants. Among Vanderbilt's other transplant ...
Liver transplantation. *Portal hypertension *Transjugular intrahepatic portosystemic shunt [TIPS]. *Distal splenorenal shunt ...
Lung transplantation. Decortication of lung. Heart-lung transplant. Chest wall, pleura,. mediastinum,. and diaphragm. pleura/ ... Median sternotomy provides wide access to the mediastinum and is the incision of choice for most open-heart surgery and access ... The Ashrafian or Aztec thoracotomy was devised to give rapid access to the heart and pericardium through an incision that ... most commonly the heart, the lungs, or the esophagus, or for access to the thoracic aorta or the anterior spine (the latter may ...
For the development of liver transplantation, which has restored normal life to thousands of patients with end-stage liver ... which have prolonged and enhanced the lives of millions of people with heart disease.[35] ... with remarkable LDL-cholesterol-lowering properties that have revolutionized the prevention and treatment of coronary heart ...
The hospital is the largest centre for child heart surgery in the UK and one of the largest centres for heart transplantation ... In 1962 they developed the first heart and lung bypass machine for children. With children's book author Roald Dahl, they ... developed an improved shunt valve for children with water on the brain (hydrocephalus), and non-invasive (percutaneous) heart ...
"We will put patients at the heart of the NHS, through an information revolution and greater choice and control' with shared ...
In 2002, the university opened the new Centre for Sports, Exercise and Health in the heart of the university precinct.[47] At a ...
creation of septal defect in heart Blalock-Hanlon procedure. shunt from heart chamber to blood vessel. atrium to pulmonary ... Heart transplantation. Diagnostic. tests and. procedures. Electrophysiology. Electrocardiography Vectorcardiography. Holter ... production of septal defect in heart. enlargement of existing septal defect Atrial septostomy. Balloon septostomy. ...
Hair transplantation is usually carried out under local anaesthetic. A surgeon will move healthy hair from the back and sides ... While there has been speculation about a connection between early-onset male pattern hair loss and heart disease, a review of ... Vertex baldness is associated with an increased risk of coronary heart disease (CHD) and the relationship depends upon the ... Scalp reduction is generally done in combination with hair transplantation to provide a natural-looking hairline, especially ...
The usual reason for a thymectomy is to gain access to the heart for surgery to correct congenital heart defects in the ... The newly formed organ resembled a normal thymus histologically and molecularly, and upon transplantation it was able to ... The thymus was known to the ancient Greeks, and its name comes from the Greek word θυμός (thumos), meaning "anger", or "heart, ... In neonates, but not older children or adults, the relative size of the thymus obstructs surgical access to the heart. Removal ...
TransplantationEdit. The definitive treatment for hepatorenal syndrome is liver transplantation, and all other therapies can ... and may require therapy with drugs to improve the strength of heart muscle contraction (inotropes) or other drugs to maintain ... The only long-term treatment option for the condition is liver transplantation. While awaiting transplantation, people with HRS ... The molecular adsorbents recirculation system (MARS) has shown some utility as a bridge to transplantation in patients with ...
Organ transplantation Transplantation of retinas has been attempted, but without much success. At MIT, The University of ... As an example, the following matrix is at the heart of a computer algorithm that implements edge detection. This matrix is the ... Successful photoreceptor transplantation, MIT Technology Review, November 2006. How stem cells might restore sight Technology ... "Retinal repair by transplantation of photoreceptor precursors" (PDF). Nature. 444 (7116): 203-7. Bibcode:2006Natur.444..203M ...
The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: A 10-year update. J ... Heart transplantation. Diagram illustrating the placement of a donor heart in an orthotopic procedure. Notice how the back of ... following Barnards landmark heart transplantation on December 3, 1967, 107 human heart transplants were performed by 64 ... Norman Shumway: Father of heart transplantation who also performed the worlds first heart-lung transplant, Obituary, The ...
A heart transplant removes a damaged or diseased heart and replaces it with a healthy one. Read about the surgery, risks, and ... The heart failure might have been caused by coronary heart disease, damaged heart valves or heart muscles, congenital heart ... Getting a New Heart (American Society of Transplantation) - PDF * What Is a Heart Transplant? (National Heart, Lung, and Blood ... About the Operation: Heart Transplant (United Network for Organ Sharing) * What Is a Total Artificial Heart? (National Heart, ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
J Heart Lung Transplant. 1996 May;15(5):536-8.. Heart-lung-liver transplantation.. Dennis CM1, McNeil KD, Dunning J, Stewart S ... Heart-lung and concurrent liver transplantation is a feasible and successful procedure with a satisfactory long-term outcome in ... Liver transplantation was necessary in the three patients with cystic fibrosis because of portal hypertension secondary to ... Three of the four patients were alive at 20, 50, and 100 months after transplantation (one patient with cystic fibrosis died on ...
Heart transplantation (HTx) remains the gold-standard treatment for those with advaced HF. Renal failure (RF) is... ... Heart failure (HF) is leading cause of morbidity and mortality in the United States. ... Simultaneous heart-kidney transplantation is superior to sequential heart-kidney transplantation in renal failure heart ... Heart and combined heart-kidney transplantation in patients with concomitant renal insufficiency and end-stage heart failure. ...
This review explores the key milestones of the past 50 years of heart transplantation. What challenges remain, and what are ... Anatomy of heart transplantation.. A, Orthotopic heart transplantation. The recipient heart is excised except for the cuffs of ... Anatomy of heart transplantation.. A, Orthotopic heart transplantation. The recipient heart is excised except for the cuffs of ... B, Heterotopic heart transplantation. The recipient native heart remains in situ while the donor heart is transplanted into the ...
Heart Transplantation Clinical Research Trial Listings in Cardiology/Vascular Diseases Trauma (Emergency, Injury, Surgery) on ... Heart Transplantation Clinical Trials. A listing of Heart Transplantation medical research trials actively recruiting patient ... Implantation Heart Transplantation and Lung Transplantation: Prospective Randomized Double-Blinded Study Inhaled Nitric Oxide ( ...
Heart Transplantation Clinical Research Trial Listings in Cardiology/Vascular Diseases Trauma (Emergency, Injury, Surgery) on ... Heart Transplantation Clinical Trials. A listing of Heart Transplantation medical research trials actively recruiting patient ... or require heart re-transplantation, because of complications related to heart transplant. These complications include heart ... Heart TIMING - Heart Transplantation IMagING 12-lead ECG - Resting standard 12-lead digital ECG will be recorded. Extended ...
Transplantation Heart Transplantation Up Next: Transplanting HCV-Infected Hearts (STAT) Infected kidneys successfully used with ... ACP: Heart Transplants Decline in the Face of Better Cardiac Care PHILADELPHIA - Fewer hearts are being transplanted in America ... Transplantation CME Spotlights. cme/ce 1.25 CREDITS Progressive Fibrosing-Interstitial Lung Disease (PF-ILD): What Clinicians ... according to a congestive heart failure update presented here. ... Latest Transplantation Meetings * No recent meetings in ...
Research in the Laboratory of Transplantation Immunotherapy, led by Dr. Richard W. Childs, is focused on finding ways to adapt ...
Hannah Valantine, who leads the Laboratory of Transplantation Genomics, has studied the causes of heart-transplant rejection ... Her research has led to fundamental discoveries about why heart transplants fail, including the pathogenesis of cardiac ...
The authors present an extremely challenging case of en bloc heart and liver transplantation in a patient with severe heart and ... This video demonstrates a "split-graft technique" for heart transplant following a hybrid bridge to transplantation approach in ... This video demonstrates a heart transplantation in a patient with an LVAD. ... Jan Gummert and Hermann Reichenspurner consider the current state of heart transplantation, including LVADs and the total ...
Cell transplantation and regrowth of heart muscle. The concept of regenerating the failing heart is in the experimental stage. ... Heart Transplantation is indicated only in the most severely ill patient: Perspectives from the German Heart Transplant ... The registry of the International Society for Heart and Lung Transplantation: Eighteenth official report - 2000. J Heart Lung ... The Registry of the International Society for Heart and Lung Transplantation: sixteenth official report--1999. J Heart Lung ...
She receives the award, endowed with CHF 30,000, for her research on inflammatory processes during heart transplantations. It ... However, every year the number of patients on heart transplantation waiting lists increases, while the number of donor hearts ... Research award for project on heart transplantation. University of Bern. Funder. Fondation Johanna Dürmüller-Bol. Keywords. * ... More than 100 DCD heart transplantations have been reported worldwide in the last 5 years, and outcomes to date are excellent. ...
Learn about the West Coasts first implant of the worlds only FDA-approved total artificial heart transplant performed here at ... Defects in heart valves leading to severe congestive heart failure Heart transplant recipients meet their donors families. ... We are the only hospital performing heart-lung and heart-liver transplants in San Diego county. We also perform heart-kidney ... Why Would Someone Need a Heart Transplant? A heart transplant is a treatment option for irreversible, life-threatening heart ...
Montefiore Medical Center, the University Hospital for Albert Einstein College of Medicine, is a premier academic medical center and nationally recognized leader in patient care, research and community service located in the Bronx, New York.
... cost-effective care for advanced heart failure, according to Journal of Cardiac Failure ... New Specialty to Focus on Advanced Heart Failure and Heart Transplantation Subspecialty cardiologists will guide delivery of ... About the Heart Failure Society of America. The Heart Failure Society of America (HFSA) is a nonprofit educational organization ... The new specialty is needed because of the rapid progress in treatment options for patients with heart failure, such as heart ...
With many more patients requiring heart transplants than there are available donor hearts, transplanted animal organs may ... Heart transplantation is the main treatment for end stage heart failure. Around 3,000 people in the US are currently on the ... Heart failure: transplantation of animal organs into human patients more viable. Published Wednesday 20 August 2014 Published ... "Heart failure: transplantation of animal organs into human patients more viable." Medical News Today. MediLexicon, Intl., 20 ...
People with end-stage heart failure for whom other treatments and medications have not helped, and who are otherwise healthy, ... Receiving a donor heart for heart transplant. If you are a match to a donor heart and it is your "turn" to receive a heart, you ... A heart transplant involves replacing a diseased heart with a healthy heart from a deceased organ donor. You may need a heart ... which does the work of the heart while your own heart is being removed. When the donor heart is transplanted into your chest, ...
Few could argue that heart transplantation would be where it is today were it not for Shumway. "He is the father of the field, ... Reunion celebrates 35 years of heart transplantation at Stanford Hospital By MICHELLE L. BRANDT. ... The medical center, celebrating 35 years of heart transplantation, has one of the most successful programs in the world. Part ... "His determination to make heart transplantation work was absolutely crucial.". Shumway oversaw more than 800 transplants during ...
A forum that includes all aspects of pre-clinical and clinical science of the failing heart and lung.The Official Publication ... The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: A 10-year update ... The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: A 10-year update ... The Journal of Heart and Lung Transplantation. A forum that includes basic science, the failing heart, and advanced lung ...
... Edward Kim,1 Hin Hin Ko,2 and Eric M Yoshida2,3,4 ... In the absence of safe and effective antiviral treatment for HCV infection in heart and lung transplant recipients, the ... Interferon therapy for HCV before transplantation appears to improve outcomes; however, post-transplant interferon therapy in ...
Does distance between home and transplantation center adversely affect patient outcomes after heart transplantation?J Heart ... Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology.Eur J Heart ... Heart Transplantation in a Distant Island Population: Accessibility and Outcomes in Patients From the Canary Islands ... Heart Transplantation in a Distant Island Population: Accessibility and Outcomes in Patients From the Canary Islands ...
When all hospitals and ambulance personnel in Sweden have received training in non-heart-beating lung donation, we hope that ... Transplantation of lungs from a non-heart-beating donor Lancet. 2001 Mar 17;357(9259):825-9. doi: 10.1016/S0140-6736(00)04195-7 ... Background: In animals, we have previously done successful lung transplantations using organs from non-heart-beating donors. We ... and to use the results to guide a clinical lung transplantation from a non-heart-beating donor. ...
... associated with immunosuppression following solid organ transplantation or allogeneic hematopoietic stem cell transplantation. ... I. Vinković, et al., " Post-transplant lymphoproliferative disorder after heart transplantation", Liječnički vjesnik, vol.141, ... Post-transplant lymphoproliferative disorder after heart transplantation. Ines Vinković ; School of Medicine University of ... Post-transplant lymphoproliferative disorder after heart transplantation." Liječnički vjesnik, vol. 141, no. suppl.1, 2019, pp ...
Home Electrocardiogram (ECG) Monitoring After Heart Transplantation (NEW HEART). The safety and scientific validity of this ... rejection to improve patient outcomes following heart transplantation. The specific goal of this study is to determine whether ... adult heart transplant recipients from recruitment sites (Columbia University-New York Presbyterian Medical Center; University ... To detect rejection, frequent endomyocardial biopsies of heart tissue are performed. An endomyocardial biopsy is a costly and ...
... heart transplantation Secondary end point: Death without transplantation Death or heart transplantation ... Prognosis in patients with severe heart failure referred for heart transplantation--POLKARD-HF 2003-2007. Int J Cardiol. 2010 ... Risk stratification of patients with severe heart failure awaiting heart transplantation-prospective national registry POLKARD ... Prognosis of patients with advanced heart failure referred for heart transplantation data of POLKARD HF 2003-2005.[Rokowanie ...
NewYork-Presbyterian has one of the largest volume heart transplant centers in the nation. Our clinicians advance the standard ... In heart transplant surgery, a patients diseased heart is removed and replaced with a healthy, donated human heart. ... Patients with end-stage heart failure who do not respond to medical treatment may be candidates for heart transplants. ... For more information about heart transplants at NewYork-Presbyterian, please visit the heart transplant section of our website. ...
Denton A. Cooley conducted the first successful heart-lung transplant in a 2-month-old girl with congestive heart failure and ... lung transplantation offers hope for a second chance at life. Today, lung transplantation is a routine treatment, however, it ... In 2016, data from the International Society for Heart and Lung Transplantation (ISHLT) registry, which tracks the outcomes of ... Lung Transplantation. For patients with end-stage lung disease, lung transplantation offers hope for a second chance at life. ...
CPMC Heart and Vascular Center. San Francisco, CA. Among the best heart transplant doctors in the United States. ... Our Heart Surgeons and Physicians - Experts in Heart Transplantation and Health. The experienced heart transplant physicians at ... Heart and Vascular Center. California Pacifics Heart and Vascular Center is supported by one of the best heart hospital/center ... A heart transplant, or a cardiac transplantation, is a surgical transplant procedure performed on patients who have experienced ...
  • A heart transplant , or a cardiac transplant , is a surgical transplant procedure performed on patients with end-stage heart failure or severe coronary artery disease when other medical or surgical treatments have failed. (
  • The world's first human-to-human heart transplant was performed by South African cardiac surgeon Christiaan Barnard utilizing the techniques developed by American surgeons Norman Shumway and Richard Lower . (
  • The baby died of acute cardiac failure shortly after the transplantation. (
  • Objective: To evaluate the effects of an early-based cardiac rehabilitation program on the functional capacity, inspiratory muscular strength and clinical outcomes in hospitalized heart failure patients before and after heart transplantation. (
  • Patients undergoing cardiac transplantation will be enrolled in the study after giving a written, signed informed consent. (
  • Her research has led to fundamental discoveries about why heart transplants fail, including the pathogenesis of cardiac allograft vasculopathy (CAV). (
  • In this interview, Shruti Jayakumar speaks with Kumud Dhital about advances in cardiac transplantation. (
  • In parallel, research w2-5 has led to the concept of cardiac replacement by transplantation. (
  • The combination of good surgical success rates and the presence of a growing number of well equipped cardiac transplant programmes has created an enormous flux of heart failure patients towards these centres. (
  • 300 in the UK, it is evident that cardiac transplantation will continue to play only a very limited quantitative role in the treatment of the advanced heart failure syndrome. (
  • The aim of this review is to outline a contemporary perspective on cardiac transplantation with respect to recipient and donor management, as well as an appropriate organisational policy. (
  • The other trend is that outcomes after cardiac transplantation have not consistently improved, due to listing of more critically ill patients, use of so-called marginal donor hearts from an extended donor pool, 1 and the initiation of new heart transplantation centres with an inevitable learning phase. (
  • A better understanding of the role of mtDAMPs in cardiac ischemia and reperfusion should aid in the optimization of clinical protocols for DCD heart transplantation, ultimately improving outcomes for patients with severe heart failure. (
  • Since then, her research has focused on the identification of novel, mitochondrial-based therapeutic tools to improve cardiac tolerance to ischemia and reperfusion, with the ultimate goal of improving patient outcomes in heart transplantation. (
  • Our program's philosophy focuses on comprehensive and compassionate patient care tailored to the individual patient, with the involvement of a multidisciplinary team of experts in the fields of advanced heart failure, cardiac surgery and cardiac transplantation. (
  • Philadelphia, 5 March 2009 - The new medical subspecialty of Advanced Heart Failure and Transplant Cardiology will lead the way in providing technically advanced yet cost-effective care for patients with heart failure, says a perspective article in the March issue of the Journal of Cardiac Failure , official publication of the Heart Failure Society of America (HFSA) and the Japanese Heart Failure Society, published by Elsevier. (
  • This development speaks for the remarkable advances in the management and outcomes of patients with heart failure, which just a few decades ago was associated with a very poor prognosis and for which there were few therapies,' comments Barry M. Massie, M.D., Editor-in-Chief of the Journal of Cardiac Failure . (
  • Journal of Cardiac Failure is the official journal of the Heart Failure Society of America and the Japanese Heart Failure Society. (
  • During this period, you'll participate in a cardiac rehabilitation program involving activities and movement to strengthen your heart and its functions, and to monitor for any signs of heart transplant rejection or infection. (
  • At Lankenau Heart Institute our Heart Failure Program provides advanced cardiac treatments and procedures for patients with end-stage heart failure. (
  • The Journal of Heart and Lung Transplantation has an Impact Factor of 5.611 and is ranked 2nd of 26 journals in Transplantation category, 6th out of 53 journals in the Respiratory System category, and 17th of 125 journals in Cardiac and Cardiovascular Systems category in the 2013 Journal Citation Reports®, published by Thomson Reuters. (
  • In 1991, the Advanced Heart Failure Unit in Madrid entered into a relationship with one of the main hospitals on the Canary Islands and established a patient referral for cardiac transplantation and a coordinated follow-up between centers. (
  • PART I 23.10.2008- 31.12.2005 Creation of the Polish national registry of patients referred for cardiac transplantation and after heart transplantation - including urgency of qualification and prognosis. (
  • A heart transplant , or a cardiac transplantation , is a surgical transplant procedure performed on patients who have experienced heart failure or severe coronary artery disease. (
  • Heart transplants are performed in our San Francisco hospital facility by our staff of trained cardiac surgeons. (
  • Following that she invested an additional year with Stanford specializing in Advanced Heart Failure and Cardiac Transplantation. (
  • Dr. Egrie is a surgeon for the mechanical assist device and heart transplantation program at CPMC, where he also serves as a cardiothoracic surgeon performing cardiac, general thoracic, and endovascular surgery. (
  • He received additional training in pediatric cardiac surgery at Boston Children's Hospital and UCSF and lung transplantation at Washington University. (
  • At Mount Sinai Heart, our cardiologists and cardiac surgeons, under the direction of Sean P. Pinney, MD , Director of Heart Failure and Transplantation, specialize in the treatment and management of patients living with mild, moderate, and advanced heart failure. (
  • Our comprehensive, integrated team of cardiologists, cardiac surgeons, researchers, nurse practitioners, nurses, social workers, and clinical care coordinators work together to offer you the full-spectrum of heart failure clinical services. (
  • Prolonged ischemic time of the donor organ can result in decreased cardiac function and poor outcome after transplantation. (
  • Background- It has been demonstrated that ventricular sympathetic reinnervation after cardiac transplantation improves exercise performance. (
  • Conclusions- The present data suggest that sympathetic reinnervation after cardiac transplantation is not simply a function of time. (
  • Acorn Cardiovascular said that the surgically implanted mesh would improve cardiac structure in heart failure patients. (
  • A Food and Drug Administration advisory panel voted 9-4 not to recommend approval of the CorCap Cardiac Support Device for patients with heart failure. (
  • After a decade, this is a timely reflection on this crisis of cardiac transplantation. (
  • A. Ali, P. White, K. Dhital, M. Ryan, S. Tsui and S. Large, "Cardiac Recovery in a Human Non-Heart-Beating Donor after Extracorporeal Perfusion: Source for Human Heart Donation? (
  • Every patient has different reactions when they receive a new heart, so it's valuable to have several options that allow us to tailor our treatment to their needs," said Hershberger, director of the OHSU Heart Failure and Cardiac Transplantation Program and professor of medicine (cardiology) at the OHSU School of Medicine. (
  • Heart transplantation, also called cardiac transplantation, is the replacement of a patient's diseased or injured heart with a healthy donor heart. (
  • Cyclosporine-induced hypertension is associated with sympathetic neural activation, which may be accentuated by the cardiac denervation that results from heart transplantation. (
  • Thus, we have discovered that inflammatory responses after cardiac transplantation are initiated through ferroptotic cell death and TLR4/Trif-dependent signaling in graft endothelial cells. (
  • Tako-Tsubo syndrome as a rare cause of cardiac failure in liver transplantation," Liver International , vol. 30, no. 1, pp. 159-160, 2010. (
  • It was shown that donor brain death significantly impairs cardiac function, which may lead to exclusion of organs from transplantation. (
  • Improved management strategies including adequate volume substitution and hormone replacement therapy can retrieve at least some of these organs for cardiac transplantation ( 1 ). (
  • Especially these groups of potential donor hearts, which are the majority of the offered organs in certain regions, would profit from improved cardiac preservation strategies. (
  • Under these circumstances, alternative cardiac preservation strategies may significantly contribute to the improvement of graft quality and outcomes after heart transplantation. (
  • Cardiac transplantation is the surgical placement of a healthy heart from a human donor into the body of a person whose own heart is badly diseased. (
  • With recent advances in surgical techniques and improved medical management of organ rejection after transplantation, an increasing number of those with end-stage cardiac disease are appropriate candidates for heart transplantation. (
  • Patients who are too ill to qualify for a heart transplant may be eligible to receive a cardiac assist device , either as a support until they can receive a transplant, or as a destination therapy. (
  • The transplant was done by a surgical team led by Dr. Eric A. Rose, director of cardiac transplantation at NewYork-Presbyterian Hospital. (
  • Khorsandi M, Curry P, Messer S. Donation After Cardiac Death Heart Transplantation: The New Frontier. (
  • Simon Messer, a specialist trainee registrar in cardiothoracic surgery and a researcher on heart donation after cardiac death (DCD) at the Royal Papworth Hospital in the UK, presents his center's experience on DCD heart transplantation as means of increasing the donor pool and reducing the waiting times for heart transplant recipients. (
  • Indirect immunofluorescent techniques used for detection of heart-reactive antibody have been used in both human and experimental cardiac transplantation. (
  • Definite evidence is presented which demonstrates the presence of circulating heart-reactive antibody preceding clinical or laboratory evidence of cardiac rejection. (
  • In all patients who lived longer than one week and died of cardiac rejection, an increase in titers of heart-reactive antibody were present prior to obvious signs of rejection and death. (
  • However, the presence of heart-reactive antibody in patients after cardiac transplantation appears to be a valuable aid in monitoring cardiac rejection. (
  • The true benefit of stem cells to heart function, however, may be in promoting cardiomyogenesis (CM, the growth of cardiac muscle). (
  • In fact, adult autologous (as in, using one's own cells) stem cells may be a novel approach for cardiac regeneration after heart attacks. (
  • Anyanwu AC, Banner NR, Radley-Smith R, Khaghani A, Yacoub MH (2002) Long-term results of cardiac transplantation from live donors: the domino heart transplant. (
  • Baldwin JC, Oyer PE, Stinson EB, Starnes VA, Billingham ME, Shumway NE (1987) Comparison of cardiac rejection in heart and heart-lung transplantation. (
  • Cardiac transplantation has become limited by a critical shortage of suitable organs from brain-dead donors. (
  • Cardiac transplantation is the "gold-standard" treatment for eligible patients with advanced heart failure. (
  • Over the last 10 years the annual mortality rate for patients awaiting cardiac transplantation was 16% ( 3 , 4 ). (
  • Overall, the clinical impact of cardiac transplantation is limited by a critical shortage of suitable donor organs ( 5 , 6 ). (
  • Cardiac transplantation is a method of choice in the treatment of patients with end-stage heart failure (HF) whose life expectancy, despite the optimal medical therapy is less than one year. (
  • In conclusion, cardiac transplantation can be performed in diabetic patients with chronic renal failure, but with significantly increased risk for further renal deterioration and even the need for chronic haemodialysis. (
  • Acute right ventricular failure after pediatric cardiac transplant: predictors and long term outcome in current era of transplantation medicine. (
  • In industrialised countries, transplantation is the treatment of choice for patients with advanced cardiac failure when other options have been exhausted. (
  • Whether cardiac reinnervation occurs after transplantation remains controversial. (
  • Power spectral analysis of heart rate variability was assessed for 1 year after cardiac autotransplantation in 9 dogs. (
  • After induction of anesthesia 13 months after transplantation, cardiac and intrinsic cardiac neuronal responses elicited by both electrical stimulation of parasympathetic or sympathetic efferent neurons and systemic or local coronary artery administration of nicotine (5 microg/kg), angiotensin II (0.75 microg/kg), and tyramine (1.2 microg/kg) were studied. (
  • The intrinsic cardiac nervous system receives reduced input from extracardiac sympathetic efferent neurons after transplantation and inconsistent input from parasympathetic efferent preganglionic neurons. (
  • The intrinsic cardiac nervous system remodels itself after cardiac transplantation, and this indicates that direct assessment of extracardiac and intrinsic cardiac neuronal behavior is required to fully understand cardiac control after transplantation. (
  • Since the Sick Kids Cardiac Transplant Program began in 1990, over 155 heart transplants have been performed at the hospital, establishing Sick Kids as one of the largest paediatric heart transplant centres in North America. (
  • In 1996, groundbreaking research by Dr. Lori West, section head of theSick Kids Cardiac Transplant Program, led to the discovery that infants could safely and successfully accept heart transplants of a different blood type, also known as an ABO-incompatible heart transplant. (
  • During heart transplantation (HTx), cardiac denervation is inevitable, thus typically resulting in chronic resting tachycardia and chronotropic incompetence with possible consequences in patient quality of life and clinical outcomes. (
  • PITTSBURGH, May 21, 2007 - Doctors at UPMC have begun a study using an investigational cardiac device, the VentrAssist™ Left Ventricular Assist System (LVAD) to see whether it can be used safely and effectively in patients with end-stage heart failure. (
  • Unlike other cardiac assist devices, the VentrAssist LVAD has a centrifugal design allowing it to operate in a way that responds to exercise more like the natural heart. (
  • Cardiac transplantation remains the gold standard in the treatment of advanced heart failure. (
  • Cardiac monitoring is a necessary part of heart-lung transplantation. (
  • Under general cardiac anesthesia, an incision is made in the patient's chest to access the heart and lungs. (
  • Once completed, the cardiac chambers are deaired as the organs fill with the patient's blood that is diverted away from the heart and lung machine. (
  • Procedures necessary for evaluation include a chest x ray , arterial blood samples, spirometric and respiratory flow studies, ventilation and perfusion scanning, and cardiac catheterization of both the right and left heart. (
  • Is the Subject Area "Cardiac transplantation" applicable to this article? (
  • Cardiac catheterization is utilized in a multitude of procedures that can help identify heart disease or defects, such as valve problems, coronary artery disease, aneurysms, and heart enlargement. (
  • Injury initiated in the donor as result of brain or cardiac death is exacerbated by organ procurement and storage, and is ultimately amplified by reperfusion injury at the time of transplantation. (
  • This video demonstrates a "split-graft technique" for heart transplant following a hybrid bridge to transplantation approach in a neonate with an underlying diagnosis of aortic atresia and hypoplastic arch. (
  • While awaiting a donor organ, these patients may have received a ventricular assist device (VAD) as a "bridge to transplantation. (
  • With national heart transplant wait times ranging from days to years, many patients look to Mechanical Circulatory Support (MCS) as a bridge to transplantation. (
  • In a non-randomised retrospective comparative study (United Network of Organ Sharing [UNOS] database analysis) comparing TAH support (n=212) with biventricular assisted device (BIVAD) support (n=366) as a bridge to transplantation (BTT) in adult patients, device support survival rates were similar in both groups (p=0.8): 95% compared with 93% at 30 days and 77% compared with 69% at 1 year. (
  • [2] Heart transplantation is not considered to be a cure for heart disease but a life-saving treatment intended to improve the quality of life for recipients. (
  • Wait list death and survival benefit of kidney transplantation among nonrenal transplant recipients. (
  • Outcomes in recipients of combined heart-kidney transplantation: multiorgan, same-donor transplant study of the International Society of Heart and Lung Transplantation/United Network for Organ Sharing Scientific Registry. (
  • Heart transplant recipients meet their donors' families. (
  • In the absence of safe and effective antiviral treatment for HCV infection in heart and lung transplant recipients, the management of these patients remains a challenge and must be considered on an individual basis. (
  • Although heart transplant recipients are often critically ill, these patients are being treated for a chronic condition, and therefore, they have been managed with pharmacologic support and/or with assist device support for long periods of time. (
  • Methods and Results- Seventy-seven nonrejecting transplant recipients were cross-sectionally studied by PET with the catecholamine analogue C-11 hydroxyephedrine at 4.8±3.5 years after transplantation. (
  • Transplant recipients of hearts from donors with severe obesity experienced no more adverse events and similar 1-year survival as those who received hearts from donors without severe obesity, according to researchers. (
  • To determine whether cyclosporine-induced hypertension is accompanied by sustained sympathetic neural activation in patients, we recorded sympathetic action potentials using intraneural microelectrodes (in the peroneal nerve) in heart-transplant recipients receiving azathioprine and prednisone alone (n = 5) or in combination with cyclosporine (n = 14). (
  • These findings provide a platform for the development of therapeutic strategies for heart transplant recipients and patients who are vulnerable to IRI following restoration of coronary blood flow. (
  • This article examines the Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients data on heart and lung transplantation in the United States from 1996 to 2005. (
  • Birks EJ, Yacoub MH, Anyanwu A, Smith RR, Banner NR, Khaghani A (2004) Transplantation using hearts from primary pulmonary hypertensive donors for recipients with a high pulmonary vascular resistance. (
  • The mechanisms accounting for the different circadian blood pressure responses in heart transplant recipients are not known. (
  • It is a review and reference for practitioners managing patients with advanced heart disease, including patients with end-stage heart failure, mechanical circulatory support or transplant recipients. (
  • Equivalent outcomes for pediatric heart transplant recipients: ABO-blood group incompatible versus ABO-compatible. (
  • The heart of the donors was implanted in the abdomen of the recipients. (
  • In contrast, heart recipients are encouraged to view the organ mechanistically-as a new pump that was rendered a spare, reusable part when a generous stranger died. (
  • In this paper it is argued that phenomenological philosophy offers a promising way to frame an ongoing empirical study that asks recipients to reflect on what it is like to incorporate the heart of another person. (
  • The authors are a cardiologist (HR), a psychiatrist (SA), a sociologist (PM), a social work researcher (JP) and a philosopher (MS). A small, empirically based study (n = 30) of how recipients understand and represent the phenomenological experience of heart transplantation is under way. (
  • Varicella-zoster virus encephalitis has not been previously reported in heart transplant recipients, to our knowledge, but has been described in patients after bone marrow transplantation or in patients with HIV infection, the authors write. (
  • Because the mortality and morbidity rates are high, aggressive diagnosis and intervention are warranted in heart transplant recipients with suspected central nervous system infection. (
  • About 85 to 90% of heart transplant recipients survive for at least 1 year. (
  • Heart transplant recipients are given immunosuppressive drugs to prevent the body from rejecting the new heart. (
  • A more reliable method is required to predict the outcome for potential heart transplant recipients with a "borderline" pulmonary vascular resistance. (
  • The withdrawal of treatment from the donor is staged to facilitate organ transplantation to recipients. (
  • However, the heart can be resuscitated with the aid of extracorporeal techniques, as was performed for the two adult recipients at St Vincent's Hospital. (
  • Approximately 3,500 heart transplants are performed every year in the world, more than half of which occur in the US. (
  • Russian scientist Vladimir Demikhov performed pioneering transplantation experiments in the 1940s and 1950s, including canine heart and heart-lung transplants. (
  • The current standard for biopsy-based diagnoses of rejection of heart transplants is the ISHLT classification from 2004, which represents a widely-used international consensus, based on morphological criteria of the cellular infiltrate within the myocardial specimen system with certainties and some arbitrary and blurred parameters. (
  • We performed over 50 heart transplants in 2018. (
  • We work closely with UC San Diego Health's lung transplant program, which has performed 22 heart-lung transplants since 1990. (
  • We are the only hospital performing heart-lung and heart-liver transplants in San Diego county. (
  • We also perform heart-kidney transplants, among other multi-organ procedures. (
  • Thirty-five years later, nearly 1,100 people have received heart transplants at Stanford - and many of the physicians and nurses, including Shumway and Miller, still work in the heart transplant program. (
  • Shumway went on to perform scores of transplants following his first in 1968 and continued his work even after the American College of Cardiology recommended a moratorium on heart transplants - because of low survival rates - in the 1970s. (
  • Patients with end-stage heart failure who do not respond to medical treatment may be candidates for heart transplants. (
  • For more information about heart transplants at NewYork-Presbyterian, please visit the heart transplant section of our website. (
  • We develop personalized plans including lifestyle modifications, medications, and, if necessary, surgical intervention including the implantation of left ventricular assist devices and heart transplants. (
  • Investigators analyzed 26,532 single-organ first-time heart transplants performed from 2003 to 2017 from the United Network for Organ Sharing database. (
  • About 2,100 heart transplants are performed every year in the United States, according to the United Network for Organ Sharing. (
  • Within six months of their heart transplants, 77 of the 216 patients in the daclizumab group reached the primary end point (rejection, heart dysfunction, death or loss to follow up), compared with 104 of the 218 patients in the placebo group (36 percent versus 48 percent). (
  • Sympathetic activity in patients with heart transplants or myasthenia gravis who were not being treated with cyclosporine was no different from that in patients with essential hypertension or in normal controls. (
  • Occasionally, heart transplants are performed on people with other forms of heart disease. (
  • Heart transplants are reserved for patients with severe heart failure. (
  • Cutting edge heart transplants give patients a new lease of life. (
  • The team has performed 61 Heart transplants, 21 combined heart and lung transplants , 1 combined heart,lung and kidney transplant, 1 combined heart and liver transplant,15 Double lung transplants and 7 single lung transplants with results on par with International standards. (
  • The number of heart transplants performed and the size of the heart waiting list continued to drop, reaching 2126 and 1334, respectively, in 2005. (
  • Ochsner's Cardiomyopathy and Heart Transplant Program is the only Medicare-approved heart transplant program in Louisiana, performing over 20 heart transplants per year. (
  • Anyanwu AC, Banner NR, Mitchell AG, Khaghani A, Yacoub MH (2003) Low incidence and severity of transplant-associated coronary artery disease in heart transplants from live donors. (
  • Given continuing improvements in surgical techniques, post-transplant monitoring and individualised drug regimes, the number of transplants performed is constrained less by the risks inherent in the procedure than by the shortage of donor hearts. (
  • Sick Kids performs on average 10 to 15 heart transplants each year, accounting for more than 80 per cent of Canada's paediatric heart transplants. (
  • Twenty-four children at Sick Kids and 56 children around the world have received ABO-incompatible heart transplants. (
  • Diederik van de Beek, MD, PhD, and colleagues at the Mayo Clinic College of Medicine, Rochester, studied 315 consecutive patients who underwent heart transplants there from January 1988 through June 2006. (
  • Various advances in surgical techniques, especially organ transplants and the prevalence of severe coronary artery disease and dilated cardiomyopathy are leading to an increase in the need for heart transplantation surgeries. (
  • The number of patients on waiting lists for heart transplants, however, is much higher than the number of available organs. (
  • Our heart transplant program is now the largest in San Diego and the third largest in California, placing it among the nation's top performing transplant centers. (
  • Advanced Heart Failure and Transplant Cardiologists will also play a critical role as leaders of specialized services, such as transplant centers and heart failure clinics. (
  • All patients with advanced heart failure referred as potential candidates for OHT in all active transplantation centers were included in the registry. (
  • Thirty-one transplantation centers around the world enrolled patients in the study between Aug. 28, 1999, and April 29, 2001. (
  • In some medical centers, heart machines can keep people alive for weeks or months until a compatible heart can be found. (
  • Transplant centers must ensure graft quality and ongoing care, define minimum caseload for accreditation, and implement specialty care units in heart failure. (
  • Donor matching is managed by the Organ Procurement and Transplantation Network (OPTN), in which all organ centers must participate according to Federal Medicare and Medicaid programs. (
  • PHILADELPHIA - Fewer hearts are being transplanted in America than a decade ago, reflecting the success of medical therapies as well as the greater use of mechanical assist devices, according to a congestive heart failure update presented here. (
  • Today, lung transplantation is a routine treatment, however, it took twenty years of research between the 40s and 60s to perfect the surgery and in August 1968, Dr. Denton A. Cooley conducted the first successful heart-lung transplant in a 2-month-old girl with congestive heart failure and recurrent pneumonia. (
  • This syndrome is also called congestive heart failure. (
  • A heart transplant is performed when congestive heart failure or heart injury can't be treated by any other medical or surgical means. (
  • Congestive Heart Failure occurs when the heart is unable to maintain adequate circulation of blood in the tissues of the body or to pump out the venous blood returned to it. (
  • Ochsner provides comprehensive management of all stages of congestive heart failure. (
  • The VentrAssist LVAD presents us with a third-generation mechanical solution for end-stage congestive heart failure that approaches the goal of minimal interference with a patient's life. (
  • Heart failure, also called congestive heart failure, is a condition where the heart cannot pump enough oxygenated blood to meet the needs of the body's other organs. (
  • The most common signs of congestive heart failure are shortness of breath, fatigue, and swollen ankles or legs. (
  • While most heart failure patients will continue to be managed by general internists or cardiologists, the new subspecialists will serve as consultants for patients with worsening heart failure and those who need more advanced care. (
  • One of the first mentions of the possibility of heart transplantation was by American medical researcher Simon Flexner , who declared in a reading of his paper on "Tendencies in Pathology" in the University of Chicago in 1907 that it would be possible in the then-future for diseased human organs substitution for healthy ones by surgery - including arteries, stomach, kidneys and heart. (
  • To test the survival of the genetically engineered pig hearts, the transplanted organs were attached to the circulatory systems of host baboons, in their abdomens. (
  • In animals, we have previously done successful lung transplantations using organs from non-heart-beating donors. (
  • We have also developed an ex-vivo system of assessing the function of such organs before transplantation. (
  • The journal's scope also addresses all aspects of advanced diseases of native thoracic organs, and includes articles with new insights into the immunology, pathogenesis, diagnosis, and management of heart failure and advanced lung disease. (
  • Boundaries regarding age, immune maturity, and therapeutic interventions to extend the applicability of ABOi HTx have been explored and resulted in data that may be useful for HTx patients beyond infancy and ABOi transplantation of other organs. (
  • In the last years, accumulating evidence shows that the transplantation of so-called marginal organs is feasible with acceptable to good clinical outcomes ( 2 ). (
  • primary cardiomyopathy , defined as changes in the structure or function of the heart muscle that cannot be attributed to a specific cause, and secondary , which is associated with disorders of the heart or other organs. (
  • In 1907, he wrote the paper "Tendencies in Pathology," in which he said that it would be possible one day by surgery to replace diseased human organs - including arteries, stomach, kidneys and heart. (
  • The shortage of donor organs has spurred interest in the use of liver allografts from non-heart beating donors (NHBDs). (
  • (A) Patients donating organs after brain death have intact cardiorespiratory function that allows donor heart evaluation to be undertaken before organ procurement. (
  • Also, due to continued shortage in donor organs, heart transplantation is a limited resource - which further underscores the importance of appropriately evaluating patients for transplant candidacy and managing their pre, peri- and post-transplant care for maximum benefit and best outcomes. (
  • Non-Heart-Beating Donors of Organs: Are the Distinctions Between Direct and Indirect Effects and Between Killing and Letting Die Relevant and Helpful. (
  • Currently, the market is witnessing rapid development in the field of regenerative therapies, such as cell therapy, gene therapy, and tissue engineering, which also involve the development of heart and/or other organs. (
  • The surgeon removes the diseased organs: in the heart, the native right and left atriums are left intact, along with the native aorta beyond the coronary arteries. (
  • Although the procurement of organs such as livers, kidneys and lungs is permitted after either brain death or circulatory death according to Acts in all jurisdictions, the procurement of hearts has traditionally only been from brain dead donors with functioning hearts. (
  • 1 , 2 More total organs have been procured (from 726 to 1193) but the number of hearts has increased only slightly from 72 of 204 donors (35%) to 79 of 378 donors (21%) over the same period. (
  • It is not declared why the heart is not included in the protocol's list of organs that may be procured. (
  • Zalawadiya SK, Wigger M, DiSalvo T, Haglund N, Maltais S, Lindenfeld J. Mechanical circulatory support and simultaneous heart-kidney transplantation: An outcome analysis. (
  • Filmed at the 2015 STS Annual Meeting in San Diego, Michael Bolanos and Mark Slaughter discuss topics in mechanical circulatory support and heart transplantation. (
  • This lecture was presented during the Glasgow Cardiopulmonary Transplantation and Mechanical Circulatory Support Symposium, a one-day symposium held at the Golden Jubilee National Hospital in Glasgow, UK. (
  • Researchers reported that with the rising prevalence of obesity in the U.S., these findings may support the inclusion of donors with obesity and larger hearts to the already critically low donor pool. (
  • This study shows that with careful selection, hearts from obese donors can be used without an increased risk to the recipient. (
  • Given the continued increase in obesity in the U.S., this research has the potential to expand the critically low donor pool by increasing the number of donors and improving outcomes for the growing list of patients with end-stage heart failure. (
  • What are non-heart beating donors (NHBDs) and what are the risks in liver transplantation for cirrhosis? (
  • therefore, the traditional approach to the transplantation of hearts from brain-dead donors is not applicable to the DCD context. (
  • The transplantation of hearts from DCD donors is now a clinical reality. (
  • Anaise D, Rapaport FT. Use of Non-Heart-Beating Cadaver Donors in Clinical Organ Transplantation--Logistics, Ethics, and Legal Considerations. (
  • Legal Issues Concerning the Use of Non-Heart-Beating Donors. (
  • Impact of Marginal Quality Donors on the Outcome of Liver Transplantation. (
  • Experience with Liver and Kidney Allografts from Non-Heart-Beating Donors. (
  • A Major Source of Kidneys for Transplantation: Non-Heart-Beating Donors (unpublished). (
  • Families of deceased donors routinely are urged to view the heart as a "gift of life" that will enable the donor to live on by extending and sustaining the life of a stranger. (
  • Donors must be under 70 years old and have not had coronary artery disease or other heart disorders. (
  • Hearts are usually procured from brain dead donors, but procurement from circulatory dead donors is a potential additional source. (
  • 1 , 2 Only 39 hearts were procured from 189 donors (21%) during the first 6 months of 2015. (
  • Dr. Hannah Valantine, who leads the Laboratory of Transplantation Genomics, has studied the causes of heart-transplant rejection since the beginning of her clinical medicine career. (
  • The activation of inflammatory responses is of particular importance in heart transplantation as they may ultimately contribute to graft rejection. (
  • To reduce the chance of rejection, you must be paired with a heart that matches as close as possible to your tissue type. (
  • Secondly, rather than employing the usual generalized immunosuppression to limit rejection of the transplanted heart, the scientists pioneered a form of target-specific immunosuppression, which is less toxic. (
  • Heart transplant rejection is a common complication and may lead to death in some patients. (
  • Graft rejection was excluded with heart biopsy and it was concluded the etiology of heart failure was anthracycline (Doxorubicin) toxicity. (
  • The long-term goal of this research is to apply novel technology for detection of donor organ (allograft) rejection to improve patient outcomes following heart transplantation. (
  • To detect rejection, frequent endomyocardial biopsies of heart tissue are performed. (
  • By Oregon Health & Science University, A new study shows that a drug, called daclizumab, is effective at reducing organ rejection and risk of infection in heart transplant patients. (
  • Following transplantation, all patients in the study received the standard anti-rejection therapy, a combination of cyclosporine, mycophenolate mofetil and corticosteroids, in addition to daclizumab or the placebo. (
  • These results confirmed what scientists discovered in an earlier study conducted on only 55 heart transplant patients at one medical center and another study of organ rejection in kidney transplant patients. (
  • Much work is needed to clarify the significance of this heart-reactive antibody in the mechanism of rejection. (
  • Burton CM, Iversen M, Scheike T, Carlsen J, Andersen CB (2008) Minimal acute cellular rejection remains prevalent up to 2 years after lung transplantation: a retrospective analysis of 2697 transbronchial biopsies. (
  • During the next four years, the regular heart biopsies showed no signs of acute cellular or humoral rejection and echocardiography showed normal graft function. (
  • Objectives: To evaluate celluar and antibody mediated rejection in a group of patients after heart transplantation (HTX), performed in the authors' institution during a six-year period. (
  • Special emphasis is placed on rejection, posttransplant systemic hypertension, pulmonary hypertension, and AB0-incompatible transplantation in children. (
  • However, heart transplantation can lead to several types of heart transplant rejection such as acute cellular rejection, acute antibody rejection, and coronary artery vasculopathy chronic rejection. (
  • This is driving the need for heart transplantation therapeutics to prevent transplant rejection. (
  • Most deaths that occur after heart transplantation are due to rejection soon after the operation or to infections. (
  • Immunosuppressants must be taken to prevent rejection of a transplanted heart. (
  • Rejection, if it occurs, may cause weakness and a rapid or other abnormal heart rhythm. (
  • When rejection occurs, the transplanted heart may not function well, causing low blood pressure and accumulation of fluid in the legs and sometimes the abdomen, resulting in swelling-a condition called edema. (
  • As of 2018 [update] , the most common procedure is to take a functioning heart , with or without transplanting one or both lungs at the same time, from a recently deceased organ donor ( brain death is the standard) and implanting it into the patient. (
  • As of 2018[update], the most common procedure is to take a functioning heart, with or without both lungs, from a recently deceased organ donor (brain death is the standard) and implanting it into the patient. (
  • In February 2018 the patient was listed for kidney transplantation. (
  • Shumway and Kantrowitz were poised for clinical application of heart transplantation when Christiaan Barnard electrified the world with the first human heart transplantation in Cape Town, South Africa, on December 3, 1967 (Figure 1A). (
  • A forum that includes all aspects of pre-clinical and clinical science of the failing heart and lung. (
  • Bearing in mind the sensitive ethical issues involved, our first aim was to find out what procedures would be acceptable, and to use the results to guide a clinical lung transplantation from a non-heart-beating donor. (
  • Texas Heart Institute (THI) conducts research through clinical trials as part of our mission to improve heart health. (
  • To address this unmet need and improve diagnostics in the area of organ transplantation, the Alberta Transplant Applied Genomics Centre (ATAGC, University of Alberta) has developed a new diagnostic system - the Molecular Microscope™ Diagnostic System (MMDx) that interprets biopsies in terms of their molecular phenotype, and combines the molecular and histopathological features of transplant biopsies, plus clinical and laboratory parameters, to create the first Integrated Diagnostic System. (
  • Now in its 18th year of continuous publication, The Journal of Heart and Lung Transplantation , the official publication of the International Society for Heart and Lung Transplantation , brings readers essential clinical information about the rapidly evolving field of intrathoracic transplantation, support, and replacement. (
  • Clinical and immunological research in ABOi transplantation has revealed insight into the immature immune system and its role in superior graft acceptance in childhood and antigen-specific tolerance. (
  • First clinical experience showed that continuous blood perfusion of donor hearts with subsequent successful transplantation is feasible. (
  • Furthermore, the Organ Care System is extremely expensive (ca. (euro)200,000 [U.S. $252,080] device costs plus ca. (euro)40,000 [U.S. $37,812] material costs per each heart procurement) and needs significantly more human resources, which-in my opinion-precludes the use of this system in the clinical routine. (
  • Are you a trainee with an interest in transplantation and an idea for a clinical trial? (
  • Reports describing the successful clinical transplantation of hearts donated after circulatory death (DCD) have recently emerged. (
  • The application of a tailored approach to DCD heart transplantation that focuses on organ resuscitation at the time of procurement, ex situ preservation, and pre-transplant assessments of organ viability has facilitated the successful clinical application of DCD heart transplantation. (
  • It is the contention of this thesis that the only prospect of improving the current impasse with the supply of donor hearts in sufficient quantity and of acceptable quality, is by the combination of appropriate laboratory models with controlled clinical trials. (
  • Staff and patients recently celebrated 15 years of clinical and research advances in heart transplantation at The Hospital for Sick Children (Sick Kids). (
  • There is a parallel U.S. clinical trial that will look at the safety and feasibility of the VentrAssist LVAD as an alternative to transplantation. (
  • The Advanced Heart Failure and Transplantation program at UK HealthCare offers a comprehensive and multidisciplinary approach to the treatment of heart disease. (
  • BACKGROUND: Although several studies have examined factors affecting survival after orthotopic heart transplantation (OHT), few have evaluated the impact of reoperative sternotomy. (
  • Heart failure (HF) is leading cause of morbidity and mortality in the United States. (
  • Heart failure is one of the leading causes of morbidity and mortality worldwide. (
  • Heart failure carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers. (
  • End-stage heart failure is associated with significant morbidity and mortality. (
  • 100 days after orthotopic heart transplantation. (
  • A , Orthotopic heart transplantation. (
  • Main goal of the study is the risk stratification of patients with advanced heart failure referred for orthotopic heart transplantation (OHT) according to HFSS score, other risk factors and biological markers and verification of their prognostic value in Polish population. (
  • However, every year the number of patients on heart transplantation waiting lists increases, while the number of donor hearts remains stable. (
  • Ventricular assist devices (VAD) represent a reasonable therapeutic alternative for patients on heart transplantation waiting lists. (
  • 12 months after PET (until 7.3±4.2 years after transplantation), but significant effects of reinnervation on outcome were not observed. (
  • Eight patients (3 percent) developed central nervous system infections, all within four years after transplantation. (
  • 4.2 In the non-randomised prospective comparative study comparing patients with TAH implantation (n=81) with matched historical controls (n=35), the survival rates at 1 and 5 years after transplantation in the TAH group were 86% and 64% compared with 69% and 34% in the control group respectively (p values not reported). (
  • Heart transplantation is considered the gold-standard therapy for end-stage systolic heart failure but the shortage of donor hearts in Germany and other countries has led to widespread use of left ventricular assist devices (LVAD). (
  • The new specialty is needed because of the rapid progress in treatment options for patients with heart failure, such as heart transplantation and ventricular assist devices (VADs). (
  • MCS devices, also known as Ventricular Assist Devices (VADs) or Left Ventricular Assist Devices (LVADs), support heart function and blood flow. (
  • Also, newly developed, implantable artificial hearts (called ventricular assist devices or VADs) that pump blood to the rest of the body are being used to tide people over until a heart is available or are used in people who are not candidates for heart transplantation. (
  • Post-transplant lymphoproliferative disorder (PTLD) is a heterogeneous group of lymphoid neoplasms associated with immunosuppression following solid organ transplantation or allogeneic hematopoietic stem cell transplantation. (
  • Immunosuppression therapy for pediatric heart transplantation. (
  • kidney transplantation (KT) after isolated HTx improves outcomes in these scenarios. (
  • Schaffer JM, Chiu P, Singh SK, Oyer PE, Reitz BA, Mallidi HR. Heart and combined heart-kidney transplantation in patients with concomitant renal insufficiency and end-stage heart failure. (
  • Effect of Donor Age on Outcome of Kidney Transplantation. (
  • Heart-lung-liver transplantation. (
  • We report three patients with cystic fibrosis and one patient with primary biliary cirrhosis and plexogenic pulmonary hypertension who have undergone heart-lung-liver transplantation as a combined procedure. (
  • Liver transplantation was necessary in the three patients with cystic fibrosis because of portal hypertension secondary to either hepatic fibrosis or established cirrhosis in addition to their advanced lung disease. (
  • Heart-lung and concurrent liver transplantation is a feasible and successful procedure with a satisfactory long-term outcome in selected patients with advanced pulmonary and hepatic disease. (
  • Following heart transplantation patients will undergo HCV antibody, virus PCR, and liver function testing. (
  • The authors present an extremely challenging case of en bloc heart and liver transplantation in a patient with severe heart and liver failure due to failing Fontan circulation. (
  • Association between liver transplant center performance evaluations and transplant volume," American Journal of Transplantation , vol. 14, no. 9, pp. 2097-2105, 2014. (
  • Takotsubo cardiomyopathy and coronary vasospasm during orthotopic liver transplantation: separate entities or common mechanism? (
  • Stress-induced cardiomyopathy (Takotsubo cardiomyopathy) after liver transplantation-report of two cases," Transplantation Proceedings , vol. 44, no. 8, pp. 2497-2500, 2012. (
  • Improved survival of patients with end-stage heart failure listed for heart transplantation: analysis of organ procurement and transplantation network/U.S. United Network of Organ Sharing data, 1990 to 2005. (
  • Although its feasibility has been demonstrated, DCD heart transplantation raises concerns as it is accompanied by a damaging period of warm ischemia (stopping of blood supply) prior to organ procurement. (
  • Advances in our understanding of ischemic post-conditioning have facilitated the development of DCD heart resuscitation strategies that can be used to minimize ischemia-reperfusion injury at the time of organ procurement. (
  • This video demonstrates a heart transplantation in a patient with an LVAD. (
  • Veteran Sean Dobbs was facing end-stage heart failure, but a left ventricular assist device (LVAD) helped him regain his health as he awaited a donor heart. (
  • In addition, Mount Sinai is home to one of the largest left ventricular assist device (LVAD) programs , for advanced heart failure patients. (
  • The VentrAssist LVAD is a mechanical blood pump that is implanted in the body to assist the heart to pump blood around the body for people with end-stage heart failure. (
  • The VentrAssist LVAD works in tandem with the natural heart and an external controller regulates the blood pump. (
  • The researchers hope that the VentrAssist LVAD investigational study will help reduce load on the patient's heart while awaiting transplant, improve blood flow and circulation and overall quality of life. (
  • As a result, they were able to be weaned off the LVAD and avoid heart transplant altogether. (
  • You may need a heart transplant if you have end-stage heart failure due to a condition such as coronary artery disease , congenital heart disease , or a viral infection. (
  • Congenital Heart Disease refers to disorders of the heart that are present at birth and that can affect adult patients in many ways. (
  • With a growing population of adult patients with congenital heart disease, there remains a need for HLT. (
  • DCD heart procurement is indeed a very exciting and relatively new approach to increasing the donor pool for heart transplantation. (
  • Following mechanical circulatory arrest (of usually of about 5 min depending on local protocol) the surgical team immediately open the chest and procure the heart (the direct DCD procurement technique) and placed on an organ care system device to resume perfusion or using normothermic regional perfusion (NRP) as per presentation above. (
  • An amendment in law is required to permit heart procurement for transplantation after circulatory death. (
  • However, to increase the availability of hearts, routine procurement after circulatory death is proposed but not yet sanctioned in the current national DCD protocol. (
  • However, despite years of investigation, the mechanisms that initiate inflammatory responses after heart transplantation remain elusive. (
  • Blood pressure responses after heart transplantation show the presence of nighttime "dippers" and "nondippers. (
  • This means that a substantial fraction of patients transplanted during childhood fail to survive to adulthood, or require heart re-transplantation, because of complications related to heart transplant. (
  • 2019). 'Heart transplantation in patient with diabetes- related microvacular and macrovascular complications', Liječnički vjesnik , 141(suppl.1), str. (
  • Vlahović V, Fabijanović D, Čikeš M, Skorić B, Miličić D. Heart transplantation in patient with diabetes- related microvacular and macrovascular complications. (
  • Concerns still exist about possible complications related to its lingering effect during and after heart transplantation. (
  • However, adverse effects of immunosuppressants, demand-supply imbalance for organ transplantation, and long-term complications associated with heart transplantation may hamper the growth of the heart transplantation therapeutics industry over the forecast period. (
  • Transplantation can cause various complications . (
  • American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 7, no. 5 Pt 2, 2007, pp. 1390-403. (
  • The heart failure might have been caused by coronary heart disease, damaged heart valves or heart muscles, congenital heart defects, or viral infections of the heart. (
  • As a consequence of improved management in acute coronary syndromes and improved longevity of the population, the number of patients with heart failure is growing. (
  • NHS-Our Healthier Nation, National Service Framework-Coronary Heart Disease. (
  • One is irreversible damage to the heart caused by coronary artery disease, commonly called "hardening of the arteries," and multiple heart attacks. (
  • These technologies help patients suffering from blockage in coronary arteries reverse the condition and prevent future blockage and heart attacks. (
  • Diagram illustrating the placement of a donor heart in an orthotopic procedure . (
  • The patient's own heart is either removed and replaced with the donor heart ( orthotopic procedure ) or, much less commonly, the recipient's diseased heart is left in place to support the donor heart (heterotopic, or "piggyback", transplant procedure). (
  • Find out how this procedure and his subsequent heart transplant not only saved his life, but changed its direction as well. (
  • Since 1970, when the first heart transplant in the Gulf South region was performed at Ochsner, more than 950 patients have undergone the procedure at Ochsner. (
  • Hence, it is argued in this paper that replacing failing hearts with functioning hearts from deceased persons must be considered much more than a complex technical procedure. (
  • 1 Yet, its importance will continue to reside with its role as the option of last resort for patients with advanced heart failure, offered within centres with a complete spectrum of medical and surgical treatment options. (
  • The current status of surgical therapies for advanced heart failure has recently been reviewed in this series. (
  • The appropriate identification of heart transplant candidates is based on the expected gain in survival and quality of life compared to all organ conserving medical and surgical treatment options in advanced heart failure. (
  • A heart transplant is a treatment option for irreversible, life-threatening heart diseases that cannot be managed by other medical or surgical methods. (
  • Responsible for post-surgical organ heart transplant patients while in the MSICU, Dr. Hershon is board-certified in Critical Care Medicine, Pulmonary Disease and Internal Medicine. (
  • Lifestyle Health & Fitness Surgical Procedures Who Pioneered Heart Transplantation? (
  • However, HLT remains to be the definitive surgical treatment for certain congenital heart disorders and Eisenmenger's syndrome. (
  • Lung transplantation is the surgical removal of a healthy lung or part of a lung from a living person and then its transfer into someone whose lungs no longer function. (
  • In a few instances, heart failure can be cured through surgical methods. (
  • For example, if heart failure is due to a leaky or narrowed heart valve, surgical repair or replacement of the valve can fix the problem. (
  • Renal function as a predictor of outcome in a broad spectrum of patients with heart failure. (
  • The objective of this investigation is to demonstrate non-inferiority in outcome of Custodiol-N against Custodiol in heart transplantation. (
  • Outcome of Transplantation of Non-Heart-Beating Donor Kidneys. (
  • Prognostic value of cystatin C in acute heart failure in relation to other markers of renal function and NT-proBNP. (
  • A few days following the transplantation his renal function continued to deteriorate and chronic haemodialysis was initiated. (
  • The pattern was generally consistent on repeated recordings from the same patient and was not related to time since transplantation, renal function, or other therapy. (
  • As a culmination of all this, in 1967, Dr. Chiristiaan Barnad, performed the first successful human heart transplantation in Cape Town, South Africa. (
  • Experience with Human Heart Transplantation. (
  • Following the first successful heart transplantation in 1967 in the Groote-Schuur-Hospital, Kapstadt, South Africa, w6 the first successful US heart transplant was performed in 1968 at Stanford University. (
  • Increasing the Supply of Cadaveric Kidneys for Transplantation. (
  • Similarly, patients who may be too sick to survive the surgery or the side effects of the drugs they must take to keep their new heart working would not be good transplant candidates. (
  • In general, transplant candidates must be under age 65 and suffering from end-stage heart disease, but be in relatively good health otherwise. (
  • These people would likely be candidates for combined heart-lung transplantation . (
  • Patients who are limited in daily activity, as defined by their doctors, and have a limited life expectancy, are candidates for heart-lung transplantation. (
  • The Official Publication of the International Society for Heart and Lung Transplantation , The Journal of Heart and Lung Transplantation brings readers essential scholarly and timely information in the field of cardiopulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. (
  • Given the severity of the patient's condition, he was again listed for heart transplant, and ultimately, retransplanted. (
  • In heart transplant surgery, a patient's diseased heart is removed and replaced with a healthy, donated human heart. (
  • When presenting for heart transplantation, the anesthesiologist should be aware of the patient's etiology of disease, baseline function, and current symptoms. (
  • Replacing a patient's diseased heart with a healthy, functioning donor heart often allows the recipient to return to normal daily activities. (
  • The patient's transplant team of heart and transplant specialists makes the final decision as to whether a donor heart is suitable for the patient. (
  • When a lung disorder has also damaged the patient's heart, one or both lungs and a heart may be transplanted at the same time. (
  • We know the term "heart failure" can be frightening, so our doctors and staff work together to create a treatment program that best suits each individual patient's needs - from the proper medication, lifestyle modification, ventricular assist support devices or, if necessary, a heart transplant. (
  • Major blood vessels are severed, and the heart is removed (B). Bronchus and blood vessels leading to the lung are severed, and the lung is removed (C). Donor heart and lung are placed in the patient's the chest cavity (D). They are sutured to their appropriate connections, and the heart is restarted before the patient is taken off the heart-lung machine (E). (
  • After adequate blood circulation is established, the patient's diseased heart is removed. (
  • The donor heart is attached to the patient's blood vessels. (
  • After the surgery, most heart transplant patients can return to their normal levels of activity. (
  • In spite of major medical advances in heart transplant patients, psychiatric comorbidity remains very high in pre-and post-transplant phases. (
  • Heart transplant patients have about a 1- 6% risk to develop the PTLD. (
  • Demonstrate the impact of the Molecular Microscope Diagnostic System as the standard of care for heart transplant patients. (
  • The results of this study are an incremental step in a long road to improving outcomes for heart transplant patients. (
  • J Heart Lung Transplant. (
  • When all other treatment options have failed in people with both heart and lung failure, a combined heart-lung transplant is needed. (
  • Our lung transplant surgeons are experts in single lung, double lung and combination heart-lung transplantations. (
  • Many people gave it up when they thought it was too difficult, but Dr. Shumway had the persistence and vision that it could work," said Reitz, who performed the world's first successful heart-lung transplant with Shumway in 1981. (
  • I believe this program has been so successful because of the tight collaborations among cardiologists, surgeons, basic scientists, immunologists, nurses and social workers," said Robert Robbins, MD, associate professor of cardiothoracic surgery and director of the Heart, Heart-Lung and Lung Transplant Program. (
  • When all hospitals and ambulance personnel in Sweden have received training in non-heart-beating lung donation, we hope that there will be enough donor lungs of good quality for all patients needing a lung transplant. (
  • ISHLT (The International Society for Heart and lung transplant) based in the US has admitted us (as the first unit in India) to participate in their registry. (
  • In 1988, the first "domino" heart transplant was performed, in which a patient in need of a lung transplant with a healthy heart will receive a heart-lung transplant, and their original heart will be transplanted into someone else. (
  • The average waiting time on the heart-lung transplant list is 795 days. (
  • B , Heterotopic heart transplantation. (
  • Although heterotopic heart transplantation had a long history in the experimental laboratory, it was first used clinically in 1974 by Losman and Barnard. (
  • 0.01) of animals submitted to heterotopic heart transplantation in the abdominal position. (
  • These might include the effects of rheumatic fever or hypertension (high blood pressure), abnormalities in the heart valves that cause damage to the heart muscle, congenital heart defects, those structural abnormalities present at birth, or rare conditions like heart tumors. (
  • Pulmonary hypertension may also lead to heart failure. (
  • Choong CK, Sweet SC, Guthrie TJ, Mendeloff EN, Haddad FJ, Schuler P et al (2005) Repair of congenital heart lesions combined with lung transplantation for the treatment of severe pulmonary hypertension: a 13-year experience. (
  • Heart transplantation alone cannot be done if people have severe pulmonary hypertension (high blood pressure in the arteries of the lungs) that has not responded to drug treatment. (
  • If heart failure is due to severe high blood pressure (hypertension), proper treatment of this can improve symptoms. (
  • On December 6, 1967, at Maimonides Hospital in Brooklyn, New York, Adrian Kantrowitz performed the world's first pediatric heart transplant. (
  • Three days later, Adrian Kantrowitz performed the world's first infant heart transplantation on an 18-day-old infant with Ebstein anomaly using the heart of an anencephalic infant. (
  • Because of its anti-inflammatory and immunodepressive effects, thalidomide has been used for the treatment of dermatologic diseases and of host-versus-graft disease in patients submitted to bone marrow transplantation. (
  • Three of the four patients were alive at 20, 50, and 100 months after transplantation (one patient with cystic fibrosis died on day 16 of pneumonia) with well-preserved pulmonary function (forced expiratory volume in 1 second 110%, 49%, and 100% predicted, respectively), normal hepatic function and New York Heart Association class 1 performance status. (
  • On June 9, 1984, "JP" Lovette IV of Denver, Colorado, became the world's first successful pediatric heart transplant. (
  • Over the decade, post-transplant graft and patient survival improved, as did the chances for survival while on the heart waiting list. (
  • This technology also facilitates assessments of organ viability to be undertaken prior to transplantation, thereby minimizing the risk of primary graft dysfunction. (
  • Transplantation of hearts from obese individuals and utilization of oversized hearts have both been associated with no increase in adverse outcomes and represent a promising, safe way to increase the donor pool," Elizabeth D. Krebs, MD, MSc , resident physician in general surgery at the University of Virginia Medical Center in Charlottesville, and colleagues wrote in Circulation: Heart Failure . (
  • Patients ineligible for transplantation may undergo VAD implantation as a destination therapy. (
  • Given Germany's low transplantation rate, VAD implantation may serve as a middle ground. (
  • In a case series of 101 patients at risk of imminent death from irreversible biventricular heart failure and eligible for transplant, survival to heart transplantation with TAH implantation as a BTT was 68% (69/101). (
  • In the case series of 101 patients with TAH implantation, survival after transplantation at 1, 5 and 10 years was 77%, 61% and 41% respectively. (
  • In the case series of 90 patients with TAH implantation, actuarial survival rates after transplantation were 78±6%, 71±6% and 63±8% at 1, 5 and 8 years respectively. (