General or unspecified injuries to the heart.
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
The hollow, muscular organ that maintains the circulation of the blood.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Injuries incurred during participation in competitive or non-competitive sports.
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Pathological conditions involving the HEART including its structural and functional abnormalities.
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
The transference of a heart from one human or animal to another.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
General or unspecified injuries involving the leg.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
Unique slender cells with multiple processes extending along the capillary vessel axis and encircling the vascular wall, also called mural cells. Pericytes are imbedded in the BASEMENT MEMBRANE shared with the ENDOTHELIAL CELLS of the vessel. Pericytes are important in maintaining vessel integrity, angiogenesis, and vascular remodeling.
Laceration or tearing of cardiac tissues appearing after MYOCARDIAL INFARCTION.
The minute vessels that connect the arterioles and venules.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Application of principles and practices of engineering science to biomedical research and health care.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
A type of extracellular vesicle, containing RNA and proteins, that is secreted into the extracellular space by EXOCYTOSIS when MULTIVESICULAR BODIES fuse with the PLASMA MEMBRANE.
Harm or hurt to the ankle or ankle joint usually inflicted by an external source.
Social welfare organizations with programs designed to assist individuals in need.
The region of the lower limb between the FOOT and the LEG.
The joint that is formed by the inferior articular and malleolar articular surfaces of the TIBIA; the malleolar articular surface of the FIBULA; and the medial malleolar, lateral malleolar, and superior surfaces of the TALUS.
A collective term for muscle and ligament injuries without dislocation or fracture. A sprain is a joint injury in which some of the fibers of a supporting ligament are ruptured but the continuity of the ligament remains intact. A strain is an overstretching or overexertion of some part of the musculature.
Computer-based systems for use in personnel management in a facility, e.g., distribution of caregivers with relation to patient needs.
A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.
A plant genus of the family ERICACEAE known for species with edible fruits.
Contractile tissue that produces movement in animals.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Cells that can give rise to cells of the three different GERM LAYERS.
An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC
Compounds based on reduced IMIDAZOLINES which contain no double bonds in the ring.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Compounds with a benzene ring fused to a thiazole ring.

Catheter-induced mechanical trauma to accessory pathways during radiofrequency ablation: incidence, predictors and clinical implications. (1/385)

OBJECTIVES: To evaluate the incidence, predictors and clinical implications of nonintentionally catheter-induced mechanical trauma to accessory pathways during radiofrequency ablation procedures. BACKGROUND: Data on the incidence and significance of catheter-induced trauma to accessory pathways are scarce. METHODS: Consecutive patients (n = 381) undergoing radiofrequency ablation of accessory pathways at two different institutions were closely monitored for appearance of mechanical block of accessory pathways during catheter manipulation. RESULTS: Mechanical trauma to accessory pathways was observed in 37 (9.7%) patients. According to a multivariate analysis, the only independent variable associated with this phenomenon was the anatomical pathway location (p = 0.0001). The incidence of trauma of either right anteroseptal (38.5%) or right atriofascicular pathways (33.3%) was significantly greater than that of pathways (< or =10%) at all remaining locations (p < 0.0001). The duration of conduction block observed ranged from < or =1 min to >30 min in 19% and 35% of patients, respectively. "Immediate" application of radiofrequency pulses at sites of mechanical block (<1 min after occurrence) was associated with a 78% long-term success rate at follow-up. This contrasted with a 25% long-term success rate in patients in whom pulses were delivered 30 min after occurrence of block ("delayed pulses"). Finally, in 24% of patients persistent trauma-induced conduction block led to discontinuation of the ablation procedure. CONCLUSIONS: Trauma to accessory pathways is more common than previously recognized and frequently results in prolongation or discontinuation of the ablation procedure and in lower success rates. The only independent predictor of catheter-trauma to accessory pathways is the pathway location.  (+info)

Intraoperative left ventricular perforation with false aneurysm formation. (2/385)

Two cases of perforation of the left ventricle during mitral valve replacement are described. In the first case there was perforation at the site of papillary muscle excision and this was recognized and successfully treated. However, a true ventricular aneurysm developed at the repair site. One month after operation rupture of the left ventricle occurred at a second and separate site on the posterior aspect of the atrioventricular ring. This resulted in a false aneurysm which produced a pansystolic murmur mimicking mitral regurgitation. Both the true and the false aneurysm were successfully repaired. In the second case perforation occurred on the posterior aspect of the atrioventricular ring and was successfully repaired. However, a false ventricular aneurysm developed and ruptured into the left atrium producing severe, but silent, mitral regurgitation. This was recognized and successfully repaired. The implications of these cases are discussed.  (+info)

Fatal outcome arising from use of a sutureless "corkscrew" epicardial pacing electrode inserted into apex of left ventricle. (3/385)

A 59-year-old man is described in whom the insertion of an epicardial sutureless "corkscrew" electrode resulted in fatal ventricular perforation. Fatal myocardial perforation can occur with this electrode and the apex of the left ventricle should never be used as the site of insertion. Necropsy also showed that the transvenous right ventricular electrode, inserted one year previously, had penetrated a tricuspid leaflet. This could have accounted for the ensuing pacing failure.  (+info)

Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts. (4/385)

BACKGROUND: Cardiomyocyte grafting augments myocyte numbers in the heart. We investigated (1) how developmental stage influences graft survival; (2) whether acutely necrotic or healing cardiac lesions support grafts; and (3) the differentiation and integration of cardiomyocyte grafts in injured hearts. METHODS AND RESULTS: Cardiomyocytes from fetal, neonatal, or adult inbred rats were grafted into normal myocardium, acutely cryoinjured myocardium, or granulation tissue (6 days after injury). Adult cardiomyocytes did not survive under any conditions. In contrast, fetal and neonatal cardiomyocytes formed viable grafts under all conditions. Time-course studies with neonatal cardiomyocytes showed that the grafts recapitulated many aspects of normal development. The adherens junction protein N-cadherin was distributed circumferentially at day 1 but began to organize into intercalated disk-like structures by day 6. The gap junction protein connexin43 followed a similar but delayed pattern relative to N-cadherin. From 2 to 8 weeks, there was progressive hypertrophy and the formation of mature intercalated disks. In some hearts, graft cells formed adherens and gap junctions with host cardiomyocytes, suggesting electromechanical coupling. More commonly, however, grafts were separated from the host myocardium by scar tissue. Gap and adherens junctions formed between neonatal and adult cardiomyocytes in coculture, as evidenced by dye transfer and localization of cadherin and connexin43 at intercellular junctions. CONCLUSIONS: Grafted fetal and neonatal cardiomyocytes form new, mature myocardium with the capacity to couple with injured host myocardium. Optimal repair, however, may require reducing the isolation of the graft by the intervening scar tissue.  (+info)

Detection of myocardial injury during transvenous implantation of automatic cardioverter-defibrillators. (5/385)

OBJECTIVES: The present study was designed to assess the extent of myocardial injury in patients undergoing transvenous implantation of an automatic implantable cardioverter-defibrillator (ICD) using cardiac troponin I (cTNI), which is a highly specific marker of structural cardiac injury. BACKGROUND: During ICD implantation, repetitive induction and termination of ventricular fibrillation (VF) via endocardial direct current shocks is required to demonstrate the correct function of the device. Transthoracic electrical shocks can cause myocardial cell injury. METHODS: Measurements of total creatine kinase (CK), CK-MB, myoglobin, cardiac troponin T (cTNT) and cTNI were obtained before and after ICD implantation in 49 consecutive patients. Blood samples were drawn before and 2, 4, 8, and 24 h after implantation. RESULTS: Elevations of CK, CK-MB, myoglobin, cTNT and cTNI above cut-off level were found in 25%, 6%, 76%, 37% and 14% of patients, respectively, with peak cTNI concentrations ranging from 1.7 to 5.5 ng/ml. Cumulative defibrillation energy (DFE), mean DFE, cumulative VF time, number of shocks as well as prior myocardial infarction (MI) were found to be significantly related to a rise of cTNI. Mean DFE > or = 18 J and a recent MI were identified as strong risk factors for cTNI rise. CONCLUSIONS: During transvenous ICD implantation myocardial injury as assessed by cTNI rise occurs in about 14% of the patients. Peak cTNI concentrations are only minimally elevated reflecting subtle myocardial cell damage. Patients with a recent MI and a mean DFE > or = 18 J seem to be prone to cTNI rise.  (+info)

Detection of myocardial injury during radiofrequency catheter ablation by measuring serum cardiac troponin I levels: procedural correlates. (6/385)

OBJECTIVES: In the present prospective controlled study, we measured blood levels of cardiac troponin I (cTnI) in patients undergoing radiofrequency (RF) catheter ablation (RFA), and we sought to investigate the degree of myocardial injury incurred by the application of RF energy and determine its procedural correlates. BACKGROUND: Measurement of serum creatine kinase (CK) levels after RFA may underestimate the degree of myocardial injury due to its thermal inactivation by RFA. Cardiac troponin I is a newer, more specific marker of myocardial injury, which may circumvent this limitation; its use in this setting has rarely been studied. METHODS: In 118 consecutive patients, 67 men and 51 women aged 38 +/- 19 years undergoing RFA for a variety of arrhythmias, cTnI and creatine kinase isoenzyme (CK-MB) levels were measured before, immediately after and 4 to 24 h after RFA. Cardiac troponin I was also measured in 39 patients (control group) having only electrophysiologic studies (EPS) without RFA. RESULTS: All RFA procedures were uncomplicated, lasted 3.2 +/- 2.0 h and included delivery of 16 +/- 22 (median: 9) RF current applications. Baseline cTnI levels averaged 0.17 +/- 0.18 ng/ml, rose to 0.88 +/- 1.12 at the end of RFA and to 2.19 +/- 2.46 at 4-24 h later. Creatine kinase isoenzyme was found to be elevated (>6 microg/l) in 32 patients (27%), while cTnI levels were increased (> or =1 ng/ml) in 80 patients (68%) (p = 0.0001). Cardiac troponin I levels correlated with the number of RF lesions applied (r = 0.53, p < 0.0001), the site of RFA, being higher with ventricular > atrial > annular lesions (p = 0.012) and the approach to the mitral annulus (transaortic > transseptal, p = 0.004). In a control group of 39 patients undergoing EPS, all but one patient had normal cTnI or CK-MB. CONCLUSIONS: The degree of myocardial injury incurred by RFA is far more accurately assessed by cTnI levels rather than by CK-MB measurements. Cardiac troponin I levels correlate with the number of RF lesions applied, the site of RFA and the approach to the mitral annulus.  (+info)

Complications of endomyocardial biopsy in children. (7/385)

OBJECTIVES: To evaluate the incidence of, and risk factors for, complications of endomyocardial biopsy in children. BACKGROUND: Endomyocardial biopsy (EMB) is a low risk procedure in adults, but there is a paucity of data with regard to performing this procedure in children. METHODS: Retrospective review of the morbidity and mortality of 1,000 consecutive EMB procedures. RESULTS: One thousand EMB procedures (right ventricle 986, left ventricle 14) were performed on 194 patients from July 1987 through March 1996. Indications for EMB included heart transplant rejection surveillance (846) and the evaluation of cardiomyopathy or arrhythmia for possible myocarditis (154). Thirty-seven (4%) procedures were performed on patients receiving intravenous inotropic support. There was one biopsy related death, secondary to cardiac perforation, in a two-week-old infant with dilated cardiomyopathy. There were nine perforations of the right ventricle, eight occurring in patients with dilated cardiomyopathy and one in a transplant recipient. The transplant patient did not require immediate intervention; two patients required pericardiocentesis alone, and six underwent pericardiocentesis and surgical intervention. All nine perforations were from the femoral venous approach (p < 0.01). Multivariate analysis demonstrated that the greatest risk of perforation occurred in children being evaluated for possible myocarditis (p = 0.01) and in those requiring inotropic support (p < 0.01). Other complications included arrhythmia (5) and single cases of coronary-cardiac fistula, flail tricuspid leaflet, pneumothorax, hemothorax, endocardial stripping and seizure. CONCLUSIONS: Risk of endomyocardial biopsy is highest in sick children with suspected myocarditis on inotropic support. However, EMB can be performed safely with very low morbidity in pediatric heart transplant recipients.  (+info)

Management of isolated sternal fractures: determining the risk of blunt cardiac injury. (8/385)

A review of the management of isolated sternal fractures in a regional cardiothoracic unit reveals that, in a 2 year period, 37 consecutive patients were admitted for observation and further investigation, including echocardiography and cardiac enzyme measurements to exclude blunt cardiac injury. Minor blunt cardiac injury was detected in only one patient, and was associated with an acutely abnormal electrocardiogram (ECG). ECG showed acute changes in 8 further patients, whilst 3 patients had an abnormal chest X-ray (CXR) due to widening of the mediastinum (1 patient had abnormal CXR and ECG), but none had evidence of cardiac injury. CXR and ECG were both normal in 23 patients, and were predictive of the absence of significant complications. A survey of 22 other cardiothoracic units around the UK confirms that the management of patients with isolated sternal fractures varies considerably from hospital to hospital. As suggested by previous reports, we believe that patients, who are otherwise fit and have normal ECG and CXR on presentation, can be safely discharged home on oral analgesics. The routine use of echocardiography and creatinine kinase (CK) assays in the assessment of isolated sternal fractures is not indicated. The introduction of these guidelines has resulted in a dramatic reduction in the number of patients admitted with isolated sternal fractures to our unit.  (+info)

TY - JOUR. T1 - Postdischarge complications after penetrating cardiac injury. T2 - A survivable injury with a high postdischarge complication rate. AU - Tang, Andrew L.. AU - Inaba, Kenji. AU - Branco, Bernardino C.. AU - Oliver, Matthew. AU - Bukur, Marko. AU - Salim, Ali. AU - Rhee, Peter. AU - Herrold, Joseph. AU - Demetriades, Demetrios. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/9. Y1 - 2011/9. N2 - Hypothesis: A significant rate of postdischarge complications is associated with penetrating cardiac injuries. Design: Retrospective trauma registry review. Setting: Level I trauma center. Patients: All patients sustaining penetrating cardiac injuries between January 2000 and June 2010. Patient demographics, clinical data, operative findings, outpatient follow-up, echocardiogram results, and outcomes were extracted. Main Outcome Measures: Cardiac-related complications and mortality. Results: During the 10.5-year study period, 406 of 40 706 trauma admissions ...
Syrian War Penetrating Cardiac Injuries in Two Aleppo Hospitals, Mahmoud Hariri, Abdul Muti Aswad, Mohamed El Edrees, Yasser Abo Khamis, Hussam Aldien Dubies, Ahmed Osama, Timothy
Background Glycated hemoglobin (HbA1c) predicts clinical cardiovascular disease or cardiovascular mortality. However, the relationship between HbA1c and myocardial injury following elective percutaneous coronary intervention (PCI) in patients with type 2 diabetes mellitus (DM) has not been investigated. Objectives The study sought to assess the relationship between HbA1c and myocardial injury following elective PCI in patients with type 2 DM. Methods We studied a cohort of consecutive 994 diabetic patients with coronary artery disease (CAD) undergoing elective PCI. Periprocedural myocardial injury was evaluated by analysis of troponin I (cTnI). The association between preprocedural HbA1c levels and the peak values of cTnI within 24 hours after PCI was evaluated. Results Peak postprocedural cTnI |1×upper limit of normal (ULN), |3×ULN and |5×ULN were detected in 543 (54.6%), 337 (33.9%) and 245 (24.6%) respectively. In the multivariate model, higher HbA1c levels were associated with less risk of
Aim : The goal of this study was to describe the epidemiology, clinical presentation, diagnostic methods, and outcome in a large series of children with blunt cardiac injury BCI. Methods : A multicenter retrospective review of all individuals less than 18 years of age diagnosed with a BCI from 1983 to 1993 was conducted. Cases included all...
20.12.2016: Commentary and debate - Standard cardiopulmonary resuscitation (CPR) is ineffective for treating traumatic cardiac arrest.
The outcome of patients in traumatic cardiac arrest presenting to deployed military medical treatment facilities: data from the UK Joint Theatre Trauma Registry ...
Experiments on pigs have shown that secretion from human embryonic stem cells can minimize heart injury by reducing tissue death by 60 per cent, say researchers.
article: Traumatic mitral valve injury by low-energy chest trauma: a rare cause of acute heart failure - Italian Journal of Emergency Medicine 2021 April;10(1):39-41 - Minerva Medica - Journals
Background-Conventional cardiac pacemakers are associated with several potential short- and long-term complications related to either the transvenous lead or subcutaneous pulse generator. We tested the safety and clinical performance of a novel completely self-contained leadless cardiac pacemaker (LCP). Methods and Results-The primary safety endpoint was freedom from complications at 90 days. Secondary performance endpoints included implant success rate, implant time and measures of device performance (pacing/sensing thresholds and rate-responsive performance). The mean age of the patient cohort (n=33) was 77 ± 8 years and 67% of the patients were male (n= 22/33). The most common indication for cardiac pacing was permanent atrial fibrillation with atrioventricular block (n = 22, 67%). The implant success rate was 97% (n= 32). Five patients (15%) required the use of ,1 LCP during the procedure. One patient developed right ventricular perforation and cardiac tamponade during the implant ...
The study involved inducing heart injury in mice, after which the mice received treatment that allows their existing cardiac fibroblasts to be converted into cardiomyocyte-like cells. This reprogramming of cardiac fibroblasts was done by locally injecting retrovirus at the site of the heart injury. The retrovirus infection delivers genes for specific cocktail of transcription factors that turn fibroblasts into cardiomyocyte-like cells.. The cardiomyocyte-like cells resulting from reprogramming cardiac fibroblasts behaved similarly to native cardiomyocytes. Not only did they express proteins found in cardiomyocytes, but they were also able to perform cell-cell communications with neighboring cells, showing that they are fully integrated into the heart tissue. Moreover, these cells were able to contract in response to electrical stimulation, which is the normal function of cardiomyocytes - causing the heart to beat and pump blood. Importantly, mice treated with fibroblast reprogramming treatment ...
(Medical Xpress)-Like clues to a crime, specific molecules in the body can hint at exposure to toxins, infectious agents or even trauma, and so help doctors determine whether and how to treat a patient. In recent years, ...
A subset of subjects with abnormal endothelial function determined during the baseline scan and good echocardiographic images will be invited to participate on this portion of the test. We will record the response to a cold pressor test (submerging their hand in ice water for 1.5 minutes) on left anterior descending coronary artery velocities with transthoracic echocardiography at baseline and after 12 weeks of CPAP therapy ...
The transcription factor GATA-2 is critical regulator of hematopoietic stem and progenitor cell (HSPC) development and function, and mutations in the enhancer region of GATA2 are linked to blood disorders. In this episode, Emery Bresnick and colleagues develop and characterize a mouse model that harbors a human disease-associated GATA2 enhancer mutation. In this model, hematopoietic development and function were normal unless the animals were exposed to a secondary stress that necessitated blood cell regeneration. The results of this study provide important insight into GATA-2-dependent pathogenesis.. ...
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently explored as a therapeutic approach for heart failure, and to this end, expression of cyclin D2 in cardiomyocytes improves outcomes in mouse models follwoing myocardial infarction. In this episode, Gerd Hasenfuß, Loren Field, and Karl Toischer discuss their collaborative effort to further evaluate the effect of increased cyclin D2 on outcomes in response to other forms of heart failure. Cyclin D2 expression improved survival and cardiac function in mice exposed to pressure overload; however, cyclin D2-espressing mice were not protected from adverse effects in response to chronic volume overload. These results support further effort into the development of strategies to improve cardiomyocyte proliferation for some types cardiac injury.. ...
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently explored as a therapeutic approach for heart failure, and to this end, expression of cyclin D2 in cardiomyocytes improves outcomes in mouse models follwoing myocardial infarction. In this episode, Gerd Hasenfuß, Loren Field, and Karl Toischer discuss their collaborative effort to further evaluate the effect of increased cyclin D2 on outcomes in response to other forms of heart failure. Cyclin D2 expression improved survival and cardiac function in mice exposed to pressure overload; however, cyclin D2-espressing mice were not protected from adverse effects in response to chronic volume overload. These results support further effort into the development of strategies to improve cardiomyocyte proliferation for some types cardiac injury.. ...
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently explored as a therapeutic approach for heart failure, and to this end, expression of cyclin D2 in cardiomyocytes improves outcomes in mouse models follwoing myocardial infarction. In this episode, Gerd Hasenfuß, Loren Field, and Karl Toischer discuss their collaborative effort to further evaluate the effect of increased cyclin D2 on outcomes in response to other forms of heart failure. Cyclin D2 expression improved survival and cardiac function in mice exposed to pressure overload; however, cyclin D2-espressing mice were not protected from adverse effects in response to chronic volume overload. These results support further effort into the development of strategies to improve cardiomyocyte proliferation for some types cardiac injury.. ...
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently explored as a therapeutic approach for heart failure, and to this end, expression of cyclin D2 in cardiomyocytes improves outcomes in mouse models follwoing myocardial infarction. In this episode, Gerd Hasenfuß, Loren Field, and Karl Toischer discuss their collaborative effort to further evaluate the effect of increased cyclin D2 on outcomes in response to other forms of heart failure. Cyclin D2 expression improved survival and cardiac function in mice exposed to pressure overload; however, cyclin D2-espressing mice were not protected from adverse effects in response to chronic volume overload. These results support further effort into the development of strategies to improve cardiomyocyte proliferation for some types cardiac injury.. ...
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently explored as a therapeutic approach for heart failure, and to this end, expression of cyclin D2 in cardiomyocytes improves outcomes in mouse models follwoing myocardial infarction. In this episode, Gerd Hasenfuß, Loren Field, and Karl Toischer discuss their collaborative effort to further evaluate the effect of increased cyclin D2 on outcomes in response to other forms of heart failure. Cyclin D2 expression improved survival and cardiac function in mice exposed to pressure overload; however, cyclin D2-espressing mice were not protected from adverse effects in response to chronic volume overload. These results support further effort into the development of strategies to improve cardiomyocyte proliferation for some types cardiac injury.. ...
Aim Statistics Case review Discuss Pre-Hospital elements Code Red Roles within the Resus Development of a Traumatic Cardiac Arrest Protocol
A new study finds COVID-19 can cause heart injury, even in people without underlying heart issues. According to research from the Chinese Center for Disease Control and Prevention (CCDC), the death rate for COVID-19 patients with heart disease was 10.5 percent. Experts say its important for people with cardiovascular
Doctors in China have already warned that heart injuries appear common in COVID-19 patients, particularly those with existing heart disease or high blood pressure. A recent, smaller study found that 12% of hospitalized patients had the complication.
Further investigation revealed that the MRL mice can regenerate almost all tissues except brain. This regenerative healing is fundamentally different from normal mammalian wound healing, and takes place without scar formation (which is of particular interest to cardiologists, since scars formed in response to heart injuries, including infarcts, are probably the primary cause of subsequent chronic heart disease and failure). Such healing is known in mammals, but only very early in development - interestingly, prior to the development of certain immune, especially inflammatory, responses. Heber-Katz et al. report that T-cells from nonhealer mice do inhibit the ear wound closure response. It doesnt seem, however, that their immune dysfunction is the only mediator of the regenerative response in MRL mice. For instance, matrix metalloproteases 2 and 9 and their specific inhibitors have been shown to be differentially activated in healer vs. non-healer mice (MMPs and MMP inhibitors are primary ...
While many people with COVID-19 suffer from respiratory disease, there is growing evidence that the virus also affects other organs. The purpose of this study is to better understand the effects of COVID-19 on the lungs and other organs. The study investigators have developed new techniques in Magnetic Resonance Imaging (MRI) to scan the lungs, heart, brain and liver. The study investigators hope to learn more about how the virus causes inflammation in these organs and how this inflammation changes over time as people recover from COVID-19 illness. The study aims to enroll 228 people in Alberta. Participants will undergo one or more MRI scans and have blood testing at one or more time points to assess for inflammation, kidney function, liver function and possible heart injury. Participants will also undergo testing to assess sense of smell, cognition (thinking and memory), spirometry (breathing test for lung function) and and exercise tolerance (walk test). The study investigators hope this ...
On the morning of the 20th of last month, in the choir, after I had celebrated Mass I yielded to a drowsiness similar to a sweet sleep. [...] I saw before me a mysterious person similar to the one I had seen on the evening of 5 August. The only difference was that his hands and feet and side were dripping blood. This sight terrified me and what I felt at that moment is indescribable. I thought I should have died if the Lord had not intervened and strengthened my heart which was about to burst out of my chest. The vision disappeared and I became aware that my hands, feet and side were dripping blood. Imagine the agony I experienced and continue to experience almost every day. The heart wound bleeds continually, especially from Thursday evening until Saturday. Dear Father, I am dying of pain because of the wounds and the resulting embarrassment I feel deep in my soul. I am afraid I shall bleed to death if the Lord does not hear my heartfelt supplication to relieve me of this condition. Will Jesus, ...
I like Stooshe enough, but Im not sure if theyre a great girl group just yet. Sure, Black Heart wound up on Chart Riggers 10 Best Pop Singles Of 2012 list. And Waterfalls was an okay, if entirely unnecessary, cover. So now were on to Slip, the latest single to promote the bands London With The Lights On album. Its a fairly nice spoonful of retro Motown, the likes of which weve heard a multitude of times before. The song makes a so-so leap into the Top 40, up to #12 this week ...
Von Hoff DD, Layard MW, Basa P, et al. Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med 1979;91:710-7. Patnaik JL, Byers T, DiGuiseppi C, et al. Cardiovascular disease competes with breast cancer as the leading cause of death for older females diagnosed with breast cancer: A retrospective cohort study. Breast Cancer Res 2011;13:R64. Plana JC, Galderisi M, Barac A, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: A report from the American society of echocardiography and the European association of cardiovascular imaging. Eur Heart J Cardiovasc Imaging 2014;15:1063-93. Jones LW, Haykowsky MJ, Swartz JJ, et al. Early breast cancer therapy and cardiovascular injury. J Am Coll Cardiol 2007;50:1435-41. Tan TC, Neilan TG, Francis S, et al. Anthracycline-induced cardiomyopathy in adults. Compr Physiol 2015;5:1517-40. Gorini S, De Angelis A, Berrino L, et al. Chemotherapeutic drugs and mitochondrial dysfunction: ...
0 mL of the solution to 25. A and Buy Zhewitra, Bilateral optic buy Zhewitra edema in a patient with ABD. CNS Stem Cells In the adult central nervous system, Feliciano DV, Burch J, et al Five thousand seven hundred sixty cardiovascular injuries in 4459 patients Epidemiologic evolution 1958 to 1987.
Background The development of sensitive myocardial-specific cardiac biomarkers allows for detection of very small amounts of myocardial injury or necrosis. Myocardial injury (MI) as a prelude of the...
TY - JOUR. T1 - Suspected myocardial contusion. T2 - Triage and indications for monitoring. AU - Wisner, David H. AU - Reed, William H.. AU - Riddick, Robert S.. PY - 1990/7. Y1 - 1990/7. N2 - Although many different tests are used to diagnose myocardial contusion, the clinical implications of the diagnosis are unclear. This makes it difficult to decide which patients require admission to a monitored bed. During 16 months, 3010 patients with blunt trauma were reviewed for evidence of sequelae attributable to myocardial contusion. None of 2204 admissions to unmonitored beds had evidence of serious arrhythmias or heart failure. No patient who died after admission had myocardial contusion at autopsy. Of the 644 admissions to monitored beds, 95 had workups for suspected contusion. Heart failure not obvious on admission did not occur and there were only four arrhythmias that required treatment. Conduction abnormalities on admission electrocardiogram predicted serious arrhythmias. Echocardiography and ...
Traumatic cardiac arrest (TCA) is a condition in which the heart has ceased to beat due to blunt or penetrating trauma, such as a stab wound to the thoracic area. It is a medical emergency which will always result in death without prompt advanced medical care. Even with prompt medical intervention, survival without neurological complications is rare. There are no definitive protocols in place in how to manage traumatic cardiac arrest, but certain people benefit from the use of a thoracotomy in order to gain access and repair damage from the injury. Traumatic cardiac arrest is a complex form of cardiac arrest often derailing from Advanced Cardiac Life Support in the sense that the emergency team must first establish the cause of the traumatic arrest and reverse these effects, for example hypovolemia and haemorrhagic shock due to a penetrating injury. Hunt PA, Greaves I, Owens WA (January 2006). Emergency thoracotomy in thoracic trauma-a review. Injury. 37 (1): 1-19. ...
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Few reports have described traumatic heart injury in children. We describe a case of acute mitral regurgitation associated with papillary muscle rupture, traumatic ventricular septal defect, and impending left ventricular free wall rupture due to blu
This study compared ischemia-modified albumin levels, a marker of ischemia in patients undergoing percutaneous coronary intervention. Ischemia-modified albumin levels were significantly lower in patients with collateral circulation compared with those without collateral circulation.
ニコランジルが、安定冠動脈疾患を有する高齢患者に対する経皮的冠動脈インターベンション施行後の心筋障害発症に与える保護的な影響:ランダム化比較試験(RINC研究)の二次解 ...
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The principles of damage control resuscitation (DCR) have been adopted into trauma resuscitation for uncontrolled haemorrhage. DCR aims to maintain circulating volume, control haemorrhage and correct the lethal triad of coagulopathy, acidosis and hypothermia until definitive intervention is appropriate. It is based on military trauma experience and uses a systematic approach with the following underlying management principles ...
Stem cell transplantation, as used clinically, suffers from low retention and engraftment of the transplanted cells. Inspired by the ability of platelets to recruit stem cells to sites of injury on blood vessels, we hypothesized that platelets might enhance the vascular delivery of cardiac stem cells (CSCs) to sites of myocardial infarction injury. Here, we show that CSCs with platelet nanovesicles fused onto their surface membranes express platelet surface markers that are associated with platelet adhesion to injury sites. We also find that the modified CSCs selectively bind collagen-coated surfaces and endothelium-denuded rat aortas, and that in rat and porcine models of acute myocardial infarction the modified CSCs increase retention in the heart and reduce infarct size. Platelet-nanovesicle-fused CSCs thus possess the natural targeting and repairing ability of their parental cell types. This stem cell manipulation approach is fast, straightforward and safe, does not require genetic alteration of the
Blunt trauma is a more frequent cause of cardiac injuries. This type of injury is common in motor vehicle accidents and may occur with any form of chest trauma, including CPR efforts. The most common injuries are myocardial contusions or hematomas. Other forms of nonischemic cardiac injury include metabolic injury due to burns, electrical current, or sepsis. These may be asymptomatic (particularly in the setting of more severe injuries) or may present with chest pain of a nonspecific nature or, not uncommonly, with a pericardial component. Elevations of cardiac enzymes are frequent but the levels do not correlate with prognosis. There are some data that the presence of certain other cardiac biomarkers, such as NT-proBNP, correlate better with significant myocardial injury. Echocardiography may reveal an akinetic segment or pericardial effusion. Cardiac MRI may also suggest acute injury. Coronary CT angiography or angiography can reveal a coronary dissection or acute occlusion if that is a ...
When you find yourself hurt in a moment, how do you cope with it? How do you recover? Do you escape through television, shopping, eating ice cream, or sitting in self-pity? These are some of the ways that I have dealt with my hurt. The only problem with these things is that they only bring […]. ...
Various types of markers have been used so far in order to reveal myocardial perfusion defect. However, these markers usually appear in the necrosis phase or in the late stage. Having been the focus of various investigations recently, ischemia-modified albumin (IMA) is helpful in establishing diagnosis in the early stages of ischemia, before necrosis develops. 30 patients that underwent only coronary bypass surgery due to ischemic heart disease within a specific period of time have been included in the study. IMA levels were studied in the preoperative, intraoperative, and postoperative periods. The albumin cobalt binding assay was used for IMA determination. Hemodynamic parameters (atrial fibrillation, the need for inotropic support, ventricular arrhythmia) of the patients in the postoperative stage were evaluated. Intraoperative measurement values (mean ± SD) of IMA (0.67677 ± 0.09985) were statistically significantly higher than those in the preoperative (0.81516 ± 0.08894) and postoperative (0
Background: Ischemia-modified albumin (IMA)is a new biological marker of ischemia. Previous studies have found increased serum IMA levels after myocardial ischemia, but no study has investigated the possibility that stroke modifies IMA blood levels.. Materials and Methods: We studied 118 consecutive patients presenting within 3 h of the onset of an acute neurological deficit [84 brain infarctions (BI), 18 brain hemorrhages (ICH) and 16 transient ischemic attacks lasting less than 1 h or epileptic seizures]. Serum samples were obtained for all patients at initial presentation and repeated only in patients with stroke at 6, 12 and 24 h. IMA was measured by the albumin-cobalt-binding test (Ischemia Technologies, Denver, Colo., USA). Results: The initial median IMA (bootstrap 95% confidence interval, CI) was 83 U/ml (79-86) and 86 U/ml (75-90) in patients with BI and ICH, respectively (p = 0.76), and was 73 U/ml (58-79) in others (p = 0.003 compared with BI, and p = 0.017 with ICH). Baseline IMA ...
Ischemia-modified albumin (IMA) is a novel marker of tissue ischemia. Nowadays, IMA is accepted as a marker of oxidative stress. In this study, we aimed at establishing an association between IMA and hyperglycemia, blood pressure, lipid parameters, microvascular complications, hsCRP, and microalbuminuria in type 2 diabetes patients without overt macrovascular disease and acute ischemia. Fifty type 2 diabetes mellitus patients without a history of macrovascular disease or end-stage renal disease were enrolled into the study. Age-matched 30 healthy individuals were also included in the study as a control group. Plasma IMA (0.329 +/- A 0.046 and 0.265 +/- A 0.045 AbsU; P < 0.0001) and hsCRP levels (0.51 +/- A 0.36 and 0.32 +/- A 0.17 mg/dl; P < 0.0001) were significantly higher in the diabetic group compared to healthy controls. IMA level was significantly correlated with hsCRP (r = 0.76; P < 0.0001), HbA1c (r = 0.72; P < 0.0001), microalbuminuria (r = 0.40; P = 0.004), systolic blood pressure (r = ...
The investigators induced heart injury in mice through transverse aortic constriction (TAC). A control group of mice underwent a surgical procedure without the aortic constriction, for comparison. They evaluated acute cardiac modeling events beginning two days after surgery, including changes in hypertrophy, collagen deposition, capillary density, and cell populations.. Within 48 hours after injury, the left ventricular free wall and septum were significantly enlarged, with an increase in heart weight and relative wall thickness compared to controls. In addition to this hypertrophy, a significant decrease in capillary density was observed two days after TAC. Increased levels of pericytes, which are connective tissue cells in small blood vessels, were associated with the reduction in capillary density, supporting earlier research that suggested a role for pericytes in stabilizing vessels and minimizing vascular remodeling. The participation of pericytes could mark the period where degradation ...
I release all the ways I feel stressed! Yes, yes, yes.. I release all the tension I am holding in my skin and showing on my face! Yes, yes, yes!. I release all the stress I am holding in my skin and showing on my face! Yes, yes, yes!. I release all the anxiety I am holding in my skin!. I release all fear I am holding in my skin!. I release any shock my skin is trying to cope with!. I release all the grief I carrying in my skin!. I release all the irritation I am holding in my skin!. I release all the fear of responsibility I am holding in my skin!. I release all my fears of being hurt that I am holding in my skin!. I release all the feelings of insecurity I am holding in my skin!. I release any impatience I am holding in my skin!. I release any feelings of being unsettled that I am holding in my skin!. I release any inner conflict that is coming to the surface of my skin!. I clear all the conflicts I have regarding intimacy!. I clear and release any disturbances which I am manifesting in my ...
Based on the DCRD evaluation of numerous device applications, and the establishment of certain criteria necessary to conduct such evaluations.
Reuters) - The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.. Use of riskier blood thinner seen in Blacks with COVID-19. A new analysis of the use of blood thinners in hospitalized COVID-19 patients highlights a striking racial disparity that may help further explain why Black patients are hit harder by the disease. The anticoagulant enoxaparin - sold under the brand name Lovenox - which is associated with superior COVID-19 outcomes, is more likely to be given to Caucasian patients. Unfractionated heparin, an alternative drug associated with more complications, is more likely to be given to Black patients, according to data from over 25,000 hospitalized COVID-19 patients in the international Discovery VIRUS registry. Treatment with unfractionated heparin was tied to more kidney injuries, heart injuries, life threatening blood infections, and anemia. Black patients ...
Vancouver, BC, Canada. Medical Research: What is the background for this study? What are the main findings?. Dr. Granville: My background is in cardiovascular research. In particular, how age affects blood vessels and how age affects mechanisms of blood vessel and heart injury and repair. We became interested in skin aging during a study in which we were studying the role of a protein degrading enzyme known as Granzyme B in atherosclerosis (hardening of the arteries) and aging. In these studies, we were using a genetic mouse model that is prone to accelerated aging, and knocked out Granzyme B. Although we were initially focused on the blood vessels, we also found that Granzyme B-deficient mice exhibited younger-looking skin. As we started to look into this, we became aware that UV light can induce the skin cells to produce Granzyme B. As sunlight is believed to be responsible for 80-90% of preventable skin aging, we generated a solar-simulated light box (with the similar ratios of UVA/UVB to ...
INVOLVED IN BMP signaling pathway (ortholog); cell aging (ortholog); cellular response to amino acid stimulus (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Fibrosis (ortholog); Heart Injuries (ortholog); FOUND IN RISC complex (ortholog); INTERACTS WITH aflatoxin B1; doxorubicin; paracetamol
Ischemia-reperfusion (IR) injury is a major cause of clinical emergencies during and after surgical procedures.Propofol protects the heart from cardiovascular IR injury by inhibiting autophagy. MicroRNAs (miRNAs)participate in anesthetic-regulated cardiovascular injury. MiR-20b-5p targets unc-51-like autophagy activatingkinase 1 (ULK1). Its role in propofol-modulated cardiovascular IR injury remains unclear, however. In thisstudy, we used an in vitro model of hypoxia-reoxygenation (HR)-induced injury to human umbilical veinendothelial cells (HUVECs) to determine the protective effect of miR-20b-5p in cells preconditioned withpropofol. We found that miR-20b-5p was significantly higher and ULK1 was lower in propofol-preconditionedHUVECs with HR injury than in HUVECs with HR injury only. Additionally, miR-20b-5p overexpressionincreased cell viability and repressed autophagy and apoptosis more in propofol-preconditioned HUVECs withHR injury than in HUVECs with HR injury only. A luciferase reporter ...
The road they found him near is a high-speed road, so everyone immediately jumped into action knowing that he had been suffered a high-velocity, high-energy strike. The potential injuries were vast - literally anything could be injured. Since the anaesthesiologist was intubating him, I started at his feet and made my way up. His feet and legs were fine. Pelvis, stable. Abdomen was soft, flat, no obvious injuries, ultrasound negative for blood in the belly. Chest was stable, no obvious rib fractures, breath sounds were equal. His heart was beating a bit fast, but the sounds werent muffled, so I doubted a blunt cardiac rupture. Arms and hands were normal. His neck looked normal ...
This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in liver, lung and heart regeneration. All chapters are contributed by pre-eminent
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I am 27 year old boy and I am problem with my forearm because when I driven car. So what kind type precaution take.-Hello there are many reasons for this ...
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Usefulness of early rule-in and rule-out biomarker protocols to estimate ischemia-induced myocardial injury in early chest pain presenters ...
Each week the editorial staff at Nature Research selects a Hot Topic from a selection of the latest research appearing in Nature.
An independent group could not replicate the results of a highly cited heart regeneration protocol, while others say they have succeeded.
I was watching The Learning Channel last night, and there was an episode about a 3 year old boy who has 40% more muscle mass than normal. HIs strength, balance…
2.2.2 Brain and spinal cord injury. *2.2.3 Heart. *2.2.4 Criticisms ... Heart[edit]. Stem cells are studied in people with severe heart disease.[24] The work by Bodo-Eckehard Strauer[25] was ... Brain and spinal cord injury[edit]. Stroke and traumatic brain injury lead to cell death, characterized by a loss of neurons ... Spinal cord injuries are one of the most common traumas brought into veterinary hospitals.[86] Spinal injuries occur in two ...
Road injury (2.7%) 9. Preterm birth (2.5%) Making up 8% of the total estimated population of 40,723, there are about 3,282 ... Ischaemic Heart Disease (9.2%) 3. Lower respiratory infection (7%) 4. Diarrhoeal disease (3.3%) 5. Self harm (3%) 6. ...
Sixteen injuries were reported; one had a heart attack, another suffered a major injury, and fourteen others with minor ... injuries. 2018 - Thirty-nine people are killed after a ten-story building collapses in the industrial city of Magnitogorsk, ...
Despite his injuries, Warmerdam survived the plane crash. In addition to Captain Gannaway, seven passengers died as a result of ... One of the survivors died of a heart attack eight weeks after the crash. She was included in a dedication to the people killed ... A ninth victim died four months after the crash from severe burn injuries. None of the passengers or crew escaped uninjured; ... eight had minor injuries. Among the seriously injured were First Officer Warmerdam and flight attendant Fech. Many of the ...
There were no injuries or ignition. 1963 A leaking gas main led to an explosion in three homes that killed a man and injured ... The gas ignited, one firefighter died from a heart attack, and nine other firefighters were injured fighting the resulting ... There were no injuries reported. 1953 A US Air Force T-33 trainer jet crashed into a natural gas pipeline bridge over the ... There were no injuries. 1957 A leaking gas main in Reno, Nevada led to three explosions on February 6. Two people were killed, ...
The sympathetic stimulation also increases the rate of heart contractions and cardiac output. Increased heart rate is also ... Traumatic brain injury Bainbridge reflex Ayling, J (2002). "Managing head injuries". Emergency Medical Services. 31 (8): 42. ... It is usually seen in the terminal stages of acute head injury and may indicate imminent brain herniation. It can also be seen ... As a result of the now defective regulation of heart rate and blood pressure, the physiologic response is decreased blood flow ...
She responded by stabbing him with one of the knives, piercing his heart and liver. He died of his injuries. Humphreys was ...
Birth Defects Program (Hòa Bình). Injury Prevention. Infection Control. Children with Congenital Heart Disease. Development of ... The injury accounts for 65% of children deaths over the age of 5 years old. ...
"Accidental self-inflicted nail gun injury to the heart". Injury Extra. 36 (11): 517-9. doi:10.1016/j.injury.2005.05.003.. ... Forty percent of those injuries occur to consumers. Nail gun injuries tripled between 1991 and 2005. Foot and hand injuries are ... Jodati, A.; Safaei, N.; Toufan, M.; Kazemi, B. (2011). "A unique nail gun injury to the heart with a delayed presentation". ... Injuries to the fingers, hands, and feet are among the three most common, but there are also injuries that involve other body ...
... back injury; carpal tunnel syndrome; diarrhoea; headache; heart problems; high blood pressure; insomnia; knee injury; low blood ... These include the conscious usage of groups of muscles, effects on health, and possible injury especially in the presence of ... From the point of view of sports medicine, asanas function as active stretches, helping to protect muscles from injury; these ... Kaivalya, Alanna (2016). Myths of the Asanas: The Stories at the Heart of the Yoga Tradition. Mandala Publishing. p. 90. ISBN ...
Nabeel has a change of heart and provides all supplies free of cost. The new circus is now ready. However, Cut succumbs to the ... injuries. Shahjahan frowns on his death and Ramsingh leaves the new circus forever. Now, Chintu is a young chap performing in ... Masand, Rajeev (30 August 2020). "Ram Singh Charlie Movie Review: Its Heart Is In Right Place". CNN-News18. Retrieved 30 August ... "has its heart in the right place but the screenplay is entirely predictable." Further saying, "Yet the film doesn't completely ...
"Subhash Tomar's ribs were fractured; injuries lead to heart-attack, claims post-mortem report". DNA India. Archived from the ... but it is not known if the heart attack was caused by blunt-force injuries that he suffered to his chest and neck. Some experts ... She was found with injury marks, including numerous bite marks, all over her body. According to reports, one of the accused men ... A medical report later said that she suffered serious injuries to her abdomen, intestines and genitals due to the assault, and ...
Jackie Tyrrell and Richie Power both returned to the Kilkenny squad after recovering from injury. Joe Canning got the first ... "Jackie Tyrrell: Inspirational speech 'from the heart'". Irish Examiner. 8 September 2015. Retrieved 9 September 2015. " ... "Kilkenny boss hails response to injuries". Irish Independent. 8 September 2015. Retrieved 9 September 2015. "Tyrrell speech ...
Never lift snow with a side-twisting motion, as that can lead to injury. Shoveling snow is a known trigger for myocardial ... People who suffer from pre-existing heart or breathing problems should consult their doctor before shoveling snow. When done ... Persons doing snow shoveling can reduce their risk of injury by shoveling snow when it is fresh and light. Slip-resistant boots ... Proper snow throwing technique minimizes strains and back injuries. Recommended technique is that when lifting snow, the user ...
No injuries were reported. On 1 May 2001, a fire broke out at the Phantasialand theme park in Brühl, near Cologne, Germany. 54 ... On 3 August 2012, a 42-year-old woman collapsed and died of a heart attack after coming off the Maelstrom ride. It has been ... His injuries were not considered to have been life-threatening despite having been serious. On 1 June 2004, a 32-year-old ... One of the casualties had to have her left leg amputated due to her injuries while a second casualty had to have her right leg ...
Falls are the leading cause of injury-related death for adults age 65 and older. Falls are also the leading cause of death in ... "National Center on Sleep Disorders Research , National Heart, Lung, and Blood Institute (NHLBI)". Retrieved ... Overexertion continues to be a leading cause of injury over all age groups. It was the second leading reason that adults age 25 ... Approximately 13% of work injuries could be attributed to sleep problems. An average of 70 people were wounded and 46 killed ...
In August 2009, Turiaf set up his "Heart to Heart" Foundation to provide medical care to children who do not have health ... "Pau Ankle Injury". 2008. Archived from the original on 2008-04-12. Retrieved 2008-03-30. "Bryant Scores Just Six of His 53 in ... "ABOUT THE HEART TO HEART FOUNDATION". Retrieved 17 December 2014. Career statistics and player information from ... Ronny Turiaf received playing time due to the many Laker injuries during the 2007-08 season. He was in the starting line-up at ...
Haikerwal is an advisor for Her Heart, a not-for-profit focused on the prevention of women's heart disease. He is Chair of the ... He underwent emergency brain surgery to remove a blood clot,and suffered a brain injury which required him to learn how to walk ... Haikerwal sustained serious head injuries in the attack, and was in a coma for 24 hours, remaining in hospital for two months. ... "Our People". Her Heart. Retrieved 13 September 2020. CS1 maint: discouraged parameter (link) Jabbal, Preeto. "Dr Mukesh Chandra ...
No injuries were reported. A magnitude 8.0 earthquake was registered on 3 March 1985 offshore Valparaíso, Valparaíso Region. It ... Two people died of heart attacks after the earthquake; one in Santiago and another in Chillán. The earthquake lasted ...
Acute kidney injury[edit]. Main article: Acute kidney injury. Acute kidney injury (AKI), previously called acute renal failure ... Heart-bypass surgery is an example of one such procedure. Drug overdoses, accidental or from chemical overloads of drugs such ... Acute kidney injury[edit]. Acute kidney injury (previously known as acute renal failure) - or AKI - usually occurs when the ... Causes of acute kidney injury include accidents, injuries, or complications from surgeries in which the kidneys are deprived of ...
Muscle belly injuries are treated with rehabilitation while tendon avulsion injuries can be treated surgically, or with rehab. ... For heart patients with low cardiac output and who are not candidates for cardiac transplantation, a procedure called ... Injuries to the latissimus dorsi are rare. They occur disproportionately in baseball pitchers. Diagnosis can be achieved by ... This procedure involves wrapping the latissimus dorsi muscles around the heart and electrostimulating them in synchrony with ...
Nance, Roscoe (February 22, 2004). "Iverson puts heart on line, ignores injuries". USA Today. Retrieved December 22, 2008. " ... Despite playing in only 60 games that season and being hampered by injuries, Iverson averaged 31.4 points per game to earn his ... He started all ten playoff games and averaged 28.5 points per game despite being hampered by a number of nagging injuries. ... Steven Kotler of Psychology Today suggested that such sleeves may act as a placebo to prevent future injuries. Fresh off their ...
"Blast Injuries: Crush Injury & Crush Syndrome" (PDF). Centers for Disease Control. Archived from the original (PDF) on 2016-03- ... Even so, abnormal heart rhythms may develop; electrocardiographic monitoring is advised, and specific treatment begun promptly ... is a medical condition characterized by major shock and kidney failure after a crushing injury to skeletal muscle. Crush injury ... Immediate untreated crush syndrome death is caused by severe head injury, torso injury with damaged abdominal organs, and ...
"Danny Paton". Heart of Midlothian FC. March 11, 2011. Archived from the original on September 16, 2012. Retrieved July 15, 2019 ... Ray Eden, 42, British cyclist, head injuries. Mayhew Foster, 99, American brigadier general, flew captured Hermann Göring to ... Leonard Lomell, 91, American World War II veteran, recipient of the Silver Star and Purple Heart, natural causes. John M. ... "Famous comedian Liaqat Soldier dies of a heart attack". SAMAA TV. April 1, 2011. Archived from the original on August 26, 2011 ...
Eads, Derry (August 28, 2009). "Laut remembered as Olympian, teacher, coach and man with heart of gold". Ventura County Star. ... Rafael, Dan; Kim, Steve (July 23, 2019). "Boxer Dadashev dies from Friday fight injuries". ESPN. Retrieved July 24, 2019. ...
One airport employee died of a heart attack. The aircraft involved in the accident was a Boeing 737-8AS with serial number ... Eighteen occupants were injured; injuries included burns and carbon monoxide poisoning. Transportation Minister Yevgeny ... Dietrich confirmed that an airport employee died of a heart attack during the emergency response. Thunderstorms were reported ...
This cardiomegaly, or enlargement of the heart, led to compression of the LRLN. Atrial Myxoma Aorta: Traumatic injury Incidence ... Cardiac disease: Left atrial enlargement due to valvular heart disease Notable case: A middle-aged male had ongoing cough, ... This was causing right heart enlargement and therefore compression of the LRLN. Idiopathic It is important to consider a ... Borow KM, Hessel SJ, Sloss LJ (1 April 1981). "Fistulous aneurysm of ductus arteriosus". Heart. 45 (4): 467-470. doi:10.1136/ ...
"Kilmarnock reject Hearts' Bryson offer". STV Sport. 21 July 2010. Retrieved 7 July 2014. "Riccarton 3 row ends Hearts' Hartley ... Bryson's Aberdeen career was hampered by injury, playing only 6 games at the start of the 2019-20 season due to an ankle injury ... "Hearts 1 Kilmarnock 2: Hearts finally broken by Bryson". The Scotsman. 4 October 2008. Retrieved 7 July 2014. "Kilmarnock 1-0 ... Hearts thus turned their attention back to Bryson and gave Kilmarnock a final "take-it-or-leave-it" offer, which included a " ...
"De Zeeuw injury confirmed". BBC Sport. 14 September 2004. Retrieved 19 November 2008. "Hearts are next stop for Burchill". BBC ... However, a knee injury suffered after less than a month put him out of action for 10 months. He recovered in time to start the ... He chose to return to Scotland and sign for Hearts, where he remained until the end of the season. On 6 July 2005, he joined ... He injured his Achilles tendon in a friendly match against Burnley, an injury which eventually required surgery, and resumed ...
"Injury Problems For McCoist". Rangers Football Club. 16 July 2014. Archived from the original on 19 July 2014. " ... "Hearts sign Scott Gallacher after goalkeeper leaves Rangers". BBC Sport. BBC. 18 July 2014. "Ibrox club loans out seven fringe ... Despite embarking on a nine-game unbeaten run in all competitions, a loss at home to Hibernian left the side trailing Hearts by ... The SPFL courted controversy with the final day fixtures by moving the Rangers v Hearts match from Saturday to Sunday, with the ...
Her son's birth may have done permanent physical injury to Margaret; despite two later marriages, she never had another child. ... I shall be as glad to please you as your heart can desire." [47] ...
Stanley suffered an injury that made him want to spend more time away from the city, and Benedict was not happy when the couple ... After Benedict died of a heart attack in 1948, Mead kept the legacy of Benedict's work going by supervising projects that ...
Alpha-lactose reverses liver injury via blockade of Tim-3-mediated CD8 apoptosis in sepsis. Clinical Immunology. July 2018, 192 ... IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts. Cellular Physiology and Biochemistry. 2016, 38 ...
"Global Heart. 14 (3): 215-240. doi:10.1016/j.gheart.2019.07.009. ISSN 2211-8179. PMID 31451236.. ... GBD 2015 Disease and Injury Incidence and Prevalence Collaborators) (October 2016). "Global, regional, and national incidence, ... Hyperosmolar hyperglycemic state, diabetic ketoacidosis, heart disease, strokes, diabetic retinopathy, kidney failure, ... Gardner, C; Wylie-Rosett, J; Gidding, SS; Steffen, LM; Johnson, RK; Reader, D; Lichtenstein, AH; American Heart Association ...
... results from a co-morbidity of several common diseases, including cancer, AIDS, congestive heart failure, COPD ( ... when the patient has a primary injury such as an immobilized broken bone (set in a cast or immobilized in traction), for ... Brown atrophy of the heart Effect of spaceflight on the human body Muscle weakness Muscular dystrophy Myotonic dystrophy ... which is a syndrome that is a co-morbidity of cancer and congestive heart failure; chronic obstructive pulmonary disease; burns ...
"Be Careful of Injuries and Good Day" (ケガに気をつけてごきげんよう, Kega ni Ki o Tsukete Gokigen'yō). September 30, 2009. ... The Virgin Mary's heart was a blue sky, an evergreen oak tree, a Japanese nightingale, a mountain lily, and a sapphire. That ... Konno notes that she put her own questions about the Virgin Mary's heart into the story via Yumi. Konno ultimately mixed ... The Virgin Mary's Heart) is often referred to in the series. In the context of the series, it is a children's song taught to ...
Zaloshnja, Eduard; Miller, Ted R.; Coben, Jeffrey; Steiner, Claudia (June 2012). "How Often Do Catastrophic Injury Victims ... congestive heart failure; chronic obstructive pulmonary disease; and complications of devices, implants and grafts.[78] ...
Thus, a thrown hand axe would not usually have penetrated deeply enough to cause very serious injuries. Nevertheless, it could ... coronary heart disease, and cerebrovascular disease, because they ate mostly lean meats and plants and frequently engaged in ...
The pose is advised against in case of high blood pressure,[14][15] heart palpitations, glaucoma,[15] during menstruation,[14] ... Sirsasana, alongside Sarvangasana and Padmasana, is one of the asanas most often reported as the cause of an injury.[16][17] ...
Severe liver injury can result from hepatic veno-occlusive disease (VOD). Elevated levels of bilirubin, hepatomegaly and fluid ... including the heart, liver, and muscle, and these cells had been suggested to have the abilities of regenerating injured tissue ... The injury of the mucosal lining of the mouth and throat is a common regimen-related toxicity following ablative HSCT regimens ... The bone marrow can be ablated (destroyed) with dose-levels that cause minimal injury to other tissues. In allogeneic ...
... one above the fetal heart, to monitor heart rate and the other at the fundus of the uterus to measure frequency of contractions ... Its presence is reassuring in predicting an absence of metabolic acidemia and hypoxic injury to the fetus at the time it is ... The fetal heart rate and the activity of the uterine muscle are detected by two transducers placed on the mother's abdomen ( ... Combined with an internal fetal monitor, an IUPC may give a more precise reading of the baby's heart rate and the strength of ...
"Heart Views. 4 (2).. copy Archived 30 November 2004 at the Wayback Machine. ... Physical medicine and rehabilitation (or physiatry) is concerned with functional improvement after injury, illness, or ... "Heart Views. 5 (2): 74-85 [80]. 2004. Archived from the original on 8 March 2013.. ... Sports medicine deals with the treatment and prevention and rehabilitation of sports/exercise injuries such as muscle spasms, ...
There were no fatalities, but there was one serious injury and 12 minor injuries. The accident was caused by icing in the fuel ... "Jet Safe After Heart-Stopping, Dead-Engine Dive". Los Angeles Times. 25 June 1982. Archived from the original on 4 June 2011. ... There were no fatalities or injuries.[175]. *On 10 June 1990, British Airways Flight 5390, a BAC One-Eleven flight between ... All 157 passengers and 13 crew escaped the aircraft, at least 14 people sustaining minor injuries.[182][183][184] ...
Ndetan HT, Rupert RL, Bae S, Singh KP (February 2009). "Prevalence of musculoskeletal injuries sustained by students while ... such as the heart, the lungs, or the stomach) that subluxation significantly contributes to, the mean response was 62%.[37] A ... A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association". Stroke. 45 (10): ...
This includes medical ventilators, incubators, anaesthetic machines, heart-lung machines, ECMO, and dialysis machines. ... diagnosis, monitoring, treatment, alleviation of or compensation for an injury or handicap, ... The electrodes contact the heart directly through the chest, allowing stimulation pulses to pass through the body. Recipients ... unreasonable risk of illness or injury and require premarket approval.[18][15][18] Examples of Class III devices include ...
This led to four deaths and serious injuries from radiation exposure. Together with caesium-134, iodine-131, and strontium-90, ... and heart function.[231] Disruption of this balance may thus be fatal: for example, ingestion of large amounts of potassium ... the improper handling of caesium-137 gamma ray sources can lead to release of this radioisotope and radiation injuries. Perhaps ...
The examination is warranted in cases where urethral injury or penetrating rectal injury is suspected;[11][12] ... However, the sensitivity of the DRE for injuries of the spinal cord, pelvis, and bowel is poor, and false positive and negative ...
Mitral valve dysfunction, congestive heart failure. Most severe. Common. Premature death. Stroke. Interrupted blood flow to the ... Physical precautionary measures have also been used to protect patients from injury, including the use of a helmet or a ... congenital heart disease, patent ductus arteriosus, and ventricular hypertrophy. Kyphoscoliosis may worsen over time and ...
2004). 1992-2001 Census of fatal occupational injuries (CFOI) Revised data. Washington, DC: U.S. Department of Labor, Bureau of ... House, J.S. (1974). Occupational stress and coronary heart disease: A review and theoretical integration. Journal of Health and ... Kidd, P., Scharf, T., & Veazie, M. (1996). Linking stress and injury in the farming environment: A secondary analysis. Health ... Psychological factors are an important factor in occupational accidents that can lead to injury and death of employees. An ...
The heart of a whale weighs about 180-200 kg. It is 640 times bigger than a human heart. The heart of the blue whale is the ... Mass strandings have been triggered by sonar activity, resulting in injury or death.[104][105][106][107] ... In addition to their streamlined bodies, they can slow their heart rate to conserve oxygen; blood is rerouted from tissue ... largest of any animal,[38] and the walls of the arteries in the heart have been described as being "as thick as an iPhone 6 ...
For example, Iguana hearts, like the majority of the squamates hearts, are composed of three chambers with two aorta and one ... Traumatic injuries on the other hand, form scars that will not allow new scales to form and disrupt the process of ecdysis.[94] ... have three-chambered hearts that become functionally four-chambered hearts during contraction. This is made possible by a ... All squamates and turtles have a three-chambered heart consisting of two atria, one variably partitioned ventricle, and two ...
... is responsible for the beneficial effects of polyenylphosphatidylcholine on ethanol-induced mitochondrial injury in rats". ... Heart valve calcification[3]. *Hypercalcemia. *Increased intracranial pressure manifesting as cerebral edema, papilledema, and ...
Heart diseaseEdit. According to a 2013 Cochrane review, listening to music may improve heart rate, respiratory rate, and blood ... the two signature injuries are posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI). These two signature ... Neurological impairments following a brain injury can be in the form of apraxia - loss to perform purposeful movements, ... Many infants show a decrease in both their average heart and respiratory rates. The infants' average blood pressure typically ...
Seems like the black-hearted devils are everywhere..."[1]. On 23 March 1944, the 504th was pulled out of the beachhead by ... with few injuries and no loss of life. They also conducted parachute training jumps out of Al Asad Airbase. ... approximately 2,700 American citizens and 1,400 civilians from other nations were evacuated without injury. However, it became ...
Such functions may be benign, like being used for a heart valve, or may be bioactive with a more interactive functionality such ... causing personal injury or damage to property. Such investigations are key to understanding, for example, the causes of various ...
"Star's injuries halt production of film." Archived 9 May 2016 at the Wayback Machine The Tuscaloosa News,, 25 March 1937. ... Deep in My Heart (1954) as Dorothy Donnelly. *The Price of Fear (1956) as Jessica Warren ... She was selected to star in Korda's 1937 film, I, Claudius, as Messalina, but her injuries in a car accident resulted in the ... injury] was a slight cut on the left eyelid; it left no mark at all. The most serious hurt was to the back of her head; it left ...
Needed for muscle, heart and digestive system health, builds bone, supports synthesis and function of blood cells Dairy ... injury, etc. Research has supported that altering inorganic mineral compounds (carbonates, oxides, etc.) by reacting them with ...
Body mass index and mortality in heart failure: A meta-analysis. Am. Heart J. (Meta-analysis, Review). 2008-07, 156 (1): 13-22 ... Diet Drug Orlistat Linked to Kidney, Pancreas Injuries. Medscape. Medscape News. [2011-04-26]. (原始内容存档于2012-05-10).. ... Am Heart J (Research Support). 2006-07, 152 (1): 140-8. PMID 16824844. doi:10.1016/j.ahj.2005.09.024.. ... National Heart, Lung, and Blood Institute. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight ...
... recuperation from illness or injury Vaidyanatha - Shiva as healer of all Ashvins, twin doctors of the gods and gods of ... goddess who presided over the heart and other organs Endovelicus, god of public health and safety Febris, goddess who embodied ...
Blunt injury of the heart. Br Med J (Clin Res Ed) 1983; 286 :805 ... Blunt injury of the heart.. Br Med J (Clin Res Ed) 1983; 286 ...
... the body of Akshay Singh the journalist who died while covering the Vyapam scam has revealed that he died of an enlarged heart ... Journalist autopsy reveals enlarged heart, no injuries: Reports The autopsy on the body of Akshay Singh the journalist who died ... ... NDTV reported citing sources that in the autopsy the heart was found to be enlarged and the lungs deeply congested. ...
Eyewitness, Heidi Haigh, told Heart:. "They (the Frankfurt fans) obviously came looking for trouble.. The Leeds fans were ... Arrests And Injuries After Leeds Friendly. 22 July 2015, 10:50 , Updated: 22 July 2015, 11:04 ...
UCF head coach Josh Heupel does not have an update on QB McKenzie Miltons injury, but is proud of the teams performance vs. ... Heupel: Milton injury breaks your heart. UCF head coach Josh Heupel does not have an update on QB McKenzie Miltons injury, ...
People who suffer acute kidney damage due to surgery are at increased risk for developing heart problems. And the level of risk ... The rate of heart problems in the group with acute kidney injuries was nearly double that of the non-injury group, the study ... home/digestion center/ digestion a-z list/ kidney injury during surgery and heart problems article ... Patients who recovered from acute kidney injuries were 67 percent more likely to have heart problems or die during the study ...
... pace bowler Olly Stone will miss the second Ashes Test after being ruled out for at least a fortnight with a back injury. ... Stone, who suffered the injury in training on Tuesday, joins fellow pacemen James Anderson and Mark Wood in being ruled out of ... Youll continue to enjoy Heart and all of its great content and features! View our Privacy Statement for more details. ... Olly that hes been ruled out of action for such an important two weeks of cricket because of a reoccurrence of his back injury ...
... and scientists have new evidence that one way to help it live is by boosting levels of a tiny RNA that helped the heart form. ... Heart muscle can continue to die even after restoring blood following a heart attack, ... In their mouse model of this ischemia/reperfusion injury of the heart, theyve found they can reduce heart muscle death 40 ... Heart, Heart Attack, Heart Disease, High Throughput, Inflammation, Ischemic Stroke, Medicine, microRNA, Molecule, Muscle, ...
... 04.09.2012. New insights on cardiac pathology reported in the ... The investigators induced heart injury in mice through transverse aortic constriction (TAC). A control group of mice underwent ... Cardiac injury leads to significant structural changes in the heart, including enlargement, excess formation of fibrous growth ... Within 48 hours after injury, the left ventricular free wall and septum were significantly enlarged, with an increase in heart ...
Brain injury is one of the most unacceptable complications sustained during heart surgery. This book presents the current ... Brain injury is one of the most unacceptable complications sustained during heart surgery. This book presents the current ... Cerebral Injury During Open Heart Surgery: Studies Using Functional, Biochemical, and Morphological Methods ... and to serve as an introduction to the overall issue of avoiding brain injury during heart surgery. The next three chapters ...
Physiology Kidney Disease Chronic Kidney Disease Acute Kidney Injury Heart Attack Myocardial Infarction ... protected against acute kidney injury via activation of hypoxia-sensing pathways, it worsened chronic kidney injury. The ... Back to School Fall Featured: Daily Wire Matters of the Heart Spring Summer test feature only channel Winter/Holidays See all ... All Journal News Cardiovascular Health Heart Disease Kidney Disease KEYWORDS. ...
Inspired by the ability of platelets to recruit stem cells to sites of injury on blood vessels, we hypothesized that platelets ... and that in rat and porcine models of acute myocardial infarction the modified CSCs increase retention in the heart and reduce ... of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and ... might enhance the vascular delivery of cardiac stem cells (CSCs) to sites of myocardial infarction injury. Here, we show that ...
... was markedly elevated only after transmural injury. In both models post-injury, the cells that form heart muscle, ... Mammalian heart regenerative capacity depends on severity of injury. 23.01.2015. Full recovery and normal function restored in ... Severe, or transmural injury, is associated with a blood supply blockage to the full thickness of the heart. Non-transmural ... Using cryoinjury - damaging the heart through exposure to extreme cold in order to mimic cellular injury caused by myocardial ...
Scran is a UK charity with a learning image service: 500,000 images, clip art, movies and sounds from museums, galleries, archives and the media; thousands of learning packs; and web tools to create, design, assemble and distribute.
Current news stories regarding Actemra and the link to heart failure, stroke, pancreatitis, lung disease, and gastrointestinal ... Levin Papantonio - Personal Injury Lawyers Representing Personal Injury Clients for Over 60 Years ... To learn more about the types of injuries that have been linked to this medication, and the legal claims that have been filed, ... Below are some of our news stories explaining the potential dangers of Actemra, and especially the connection to heart failure ...
Of many clinical researchers from around the world presenting findings in congenital heart disease at Cardiology 2015, ... Childrens heart disease topics: Brain injury, radiation exposure, CPR and more Featured lectures at Cardiology 2015 Conference ... Childrens heart disease topics: Brain injury, radiation exposure, CPR and more. Childrens Hospital of Philadelphia ... Risk of White-Matter Injury Before Infant Cardiac Surgery Linked to Oxygen Flow in Brain Recent research in infants with ...
Figure 8: Effect of DBD on cytokine in heart. For IL-6, TNF-α, and IL-1β assay in heart, the mice heart samples were ... Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice. Kun Liu,1 Xiu-mei Ren,2 ... Western blot analysis revealed that DBD ameliorated CTX-challenged heart injury possibly through the IKK/IκB/NF-κB signaling ... Effect of DBD on Cytokine in Heart. As depicted in Figure 8, IL-6, IL-1β, and TNF-α levels in heart were increased in CTX- ...
Patients with HCM had lower heart rates at maximum exercise (p,0.001) and lower heart rate pressure products than mutation ... Heart 2020; 106 1447-1447 Published Online First: 10 Jul 2020. doi: 10.1136/heartjnl-2020-316890 ... This shows that exercise per se does not cause injury in the majority of patients with HCM, and that CMRi may identify a ... Exercise and hypertrophic cardiomyopathy: time for a change of heart. Circulation 2018;137:419-21.doi:10.1161/CIRCULATIONAHA. ...
MRL mice fail to heal the heart in response to ischemia-reperfusion injury.. Abdullah I1, Lepore JJ, Epstein JA, Parmacek MS, ... AND heart[Title] AND response[Title] AND ischemia-reperfusion[Title] AND injury[Title]). Search. ... AND heart[Title] AND response[Title] AND ischemia-reperfusion[Title] AND injury[Title]) ... There was no evidence of resistance to cardiac injury or of reduced scar formation in the MRL mice compared to C57/Bl6 controls ...
BIOCHEMICAL MARKERS OF MYOCYTE INJURY IN PATIENTS WITH HEART FAILURE. cTnT. Congestive heart failure is a clinical syndrome ... European Study Group on Diastolic Heart Failure. How to diagnose diastolic heart failure. Eur Heart J1998;19:990-1003. ... hypertensive heart disease, valvar heart disease, or congenital heart disease.41 While both cTnT and H-FABP were associated ... Studies of MLC-1, a 27 kD protein, as a biochemical marker of myocyte injury in patients with heart failure are few. Hansen and ...
Delivering stem cell factor directly into damaged heart muscle after a heart attack may help repair and regenerate injured ... Heart disease is the number one cause of death in the United States, with cardiomyopathy or an enlarged heart from heart attack ... Delivering stem cells into heart muscle may enhance cardiac repair and reverse injury. The Mount Sinai Hospital / Mount Sinai ... Delivering stem cells into heart muscle may enhance cardiac repair and reverse injury Study findings by Icahn School of ...
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.. Kim AS1, Miller EJ, Wright TM, Li J, ... A-769662 activates the AMPK pathway and protects the heart against ischemia-reperfusion injury in vitro ... Intrinsic AMPK activation protects the heart against ischemic injury and apoptosis, but whether pharmacologic AMPK stimulation ... A) Isolated C57Bl/6 mouse hearts were treated with A-769662 (100 μmol/L) or vehicle for 30 min of aerobic perfusion. Heart ...
Chinese skullcap can prevent liver injury caused by heart failure. Liver injury caused by heart disease can be reduced by ... heart disease, herbal medicine, Herbs, inflammation, liver damage, liver health, liver injury, myocardial ischemia and ... Chinese skullcap can prevent liver injury caused by heart failure. Monday, August 19, 2019 by: Michelle Simmons Tags: alanine ...",Chinese skullcap can ...
Experiments on pigs have shown that secretion from human embryonic stem cells can minimize heart injury by reducing tissue ... Athletes Foot Stem Cells - Cord Blood Stem Cells - Fundamentals Genetics and Stem Cells Heart Healthy Heart Statins Mitral ... Research: Embryonic Stem Cell Secretions Reduce Intensity of Heart Injury in Pigs. ... blood flow to the oxygen-deprived heart after a heart attack-which is currently the best therapeutic option available to heart ...
While the injury will put off some sides, at a cost of £450,000 in compensation to free him from Hearts, hell still be a risk ... Hearts Callum Paterson holds his shirt over his face as he is carried off after sustaining a serious knee injury against ... But what about the clubs? If Paterson was about to sign a five-year deal with Hearts and then sustained the injury, would the ... It means Hearts could get the player to sign a new deal. How much of a goodwill gesture such an offer would be is up to them. ...
Working on inflammatory injury in heart transplant Message Subject. (Your Name) has forwarded a page to you from Science ... Ex vivo perfusion for preservation of donor hearts may be improved by preventing inflammatory tissue injury, including through ... Ex vivo perfusion for preservation of donor hearts may be improved by preventing inflammatory tissue injury, including through ... Ex vivo perfusion for preservation of donor hearts may be improved by preventing inflammatory tissue injury, including through ...
Aldose Reductase Inhibition Protects Diabetic and Nondiabetic Rat Hearts from Ischemic Injury. ... In these diabetic hearts, ATP was significantly higher in zopolrestat hearts during ischemia, as were phosphocreatine and left ... Aldose Reductase Inhibition Protects Diabetic and Nondiabetic Rat Hearts from Ischemic Injury ... Aldose Reductase Inhibition Protects Diabetic and Nondiabetic Rat Hearts from Ischemic Injury ...
Pharmacological Activation of Soluble Guanylate Cyclase Protects the Heart Against Ischemic Injury. Sevil Korkmaz, Tamás ... 2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ... Pharmacological Activation of Soluble Guanylate Cyclase Protects the Heart Against Ischemic Injury ... Pharmacological Activation of Soluble Guanylate Cyclase Protects the Heart Against Ischemic Injury ...
I Heart Guts is the brainchild of an anatomically obsessed illustrator who loves internal organs and all they do... READ MORE » ... Returns Policy , Privacy Policy , Terms of Service , [email protected] , © I Heart Guts 2021, site by Aeolidia ... From the websites schedule, it looks like this giant brain wont be floating by you anytime soon, but we still heart it anyway ... Tags: Acoustic Neuroma Acquired Brain Injury Agenesis Corpus Callosum Alzheimers Disease Amyotrophic Lateral Diseases Aneurysm ...
... , thats what research published in Experimental Physiology and carried out by researchers ... The heart undergoes changes after spinal cord injury that are dependent on how severe the spinal cord injury is but only a ... Spinal cord injury affects the heart, thats what research published in Experimental Physiology and carried out by researchers ... This is important as individuals with spinal cord injury are at a much higher risk for heart disease than people without spinal ...
GP to appeal decision that failure to refer patient for heart tests led to spinal injury BMJ 2019; 367 :l6547 ... GP to appeal decision that failure to refer patient for heart tests led to spinal injury ... GP to appeal decision that failure to refer patient for heart tests led to spinal injury ... GP to appeal decision that failure to refer patient for heart tests led to spinal injury. BMJ 2019; 367 doi: ...
  • In their mouse model of this ischemia/reperfusion injury of the heart, they've found they can reduce heart muscle death 40 percent by giving a manmade version of the microRNA miR322, they report in the Journal of Molecular and Cellular Cardiology . (
  • For these studies, they caused an occlusion in the left coronary artery of mice for about 45 minutes, then enabled reperfusion to reflect what happens when a human has a heart attack, then gets treatment. (
  • We still need to see how and if it can protect the heart long term, but we find in the short term when we give enough of this microRNA, it protects the heart from reperfusion injury. (
  • MRL mice fail to heal the heart in response to ischemia-reperfusion injury. (
  • We therefore sought to assess the capacity of adult MRL myocardium to regenerate in a left ventricular ischemia-reperfusion model of myocardial infarction, which more closely recapitulates injury that occurs in human disease. (
  • A small molecule AMPK activator protects the heart against ischemia-reperfusion injury. (
  • Intrinsic AMPK activation protects the heart against ischemic injury and apoptosis, but whether pharmacologic AMPK stimulation mitigates ischemia-reperfusion damage is unknown. (
  • The aims of this study were to determine whether direct stimulation of AMPK using a small molecule activator, A-769662, attenuates myocardial ischemia-reperfusion injury and to examine its cardioprotective mechanisms. (
  • 0.01) during post-ischemic reperfusion compared to control hearts. (
  • AMPK is a therapeutic target that can be stimulated by a direct-acting small molecule in order to prevent injury during ischemia-reperfusion. (
  • C) Isolated C57Bl/6 hearts were treated with A-769662 (100 μmol/L) or vehicle for 30 min prior to global no-flow ischemia (25 min) and reperfusion (30 min). (
  • Isolated AMPK inactivated kinase dead (KD) hearts were treated with A-769662 (100 μmol/L) or vehicle for 30 min during baseline aerobic perfusion, prior to global no-flow ischemia (25 min) and subsequent reperfusion (30 min) without compound. (
  • In a recent study published in The American Journal of Chinese Medicine , baicalein was found to reduce liver injury induced by myocardial ischemia and reperfusion (I/R). (
  • The researchers insist that by demonstrating the efficacy of this secretion in an experimental pig model, they have addressed the longstanding problem of reperfusion injury in the most clinically relevant experimental setting. (
  • The findings attain significance as they show that the new method can overcome the unwanted side effects of reperfusion-the restoration of blood flow to the oxygen-deprived heart after a heart attack-which is currently the best therapeutic option available to heart attack patients. (
  • The cytosolic redox state (NADH/NAD + ), as measured by lactate-topyruvate ratios, was significantly lowered under baseline, ischemic, and reperfusion conditions in diabetic hearts perfused with zopolrestat. (
  • In these diabetic hearts, ATP was significantly higher in zopolrestat hearts during ischemia, as were phosphocreatine and left ventricular-developed pressure on reperfusion. (
  • These data indicate that inhibition of aldose reductase activity preserves high-energy phosphates, maintains a lower cytosolic NADH/NAD + ratio, and markedly protects both diabetic and nondiabetic hearts during ischemia and reperfusion. (
  • Our previous results indicated that a single dosing of CP pretreatment at 0.8 g/kg attenuates ischemia/reperfusion- (I/R-) induced myocardial injury and cardiac microcirculatory disturbance. (
  • Although percutaneous coronary intervention (PCI) is currently used in clinic to restore myocardial perfusion, ischemia/reperfusion- (I/R-) induced injury may lead to cardiac electrical dysfunction and permanent contractile disability. (
  • The functional and metabolic effects of NO on ischemia-reperfusion injury are still controversial. (
  • The aim of this study was to clarify the relationship between the degree of NO synthase (NOS) inhibition and the effects on ischemia-reperfusion injury. (
  • Langendorff-perfused rat hearts were subjected to 30 minutes of global ischemia followed by 30 minutes of reperfusion. (
  • Both effects of L-NMMA were abolished by excessive co-administration of L-arginine and the same doses of D-N(G)-monomethyl arginine (D-NMMA) showed no effect on ischemia-reperfusion injury. (
  • However, strong vasoactive inhibition of NOS exacerbated the ischemia-reperfusion injury. (
  • Restored blood flow quickly rescues myocardium but also causes ischemia-reperfusion (IR) injury. (
  • Brief episodes of ischemia at a distant organ could reduce the myocardial reperfusion injury. (
  • Arimura T, Saku K, Kakino T, Nishikawa T, Tohyama T, Sakamoto T, Sakamoto K, Kishi T, Ide T, Sunagawa K (2017) Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure. (
  • Zhang P, Lv J, Li Y, Zhang L, Xiao D. Neonatal Lipopolysaccharide Exposure Gender-Dependently Increases Heart Susceptibility to Ischemia/Reperfusion Injury in Male Rats. (
  • lipopolysaccharide, neonatal exposure, ischemia/reperfusion injury. (
  • Clq/TNF-Related Protein 9 Protects Diabetic Rat Heart against Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress. (
  • Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1/2 pathway. (
  • Aim:To investigate the role of extracellular signal-regulated kinases (ERKs) in sevoflurane post-conditioning induced cardioprotection in vitro.Methods:Isolated rat hearts were subjected to 30 min ischemia followed by 120 min reperfusion (I/R). Sevoflurane post-conditioning was carried out by administration of O2-enriched gas mixture with 3% sevoflurane (SEVO) for 15 min from the onset of reperfusion. (
  • Remote pharmacological preconditioning on median nerve territory increases Hsp32 expression and attenuates ischemia-reperfusion injury in rat heart. (
  • AIMS: The aim of this study was to test the hypothesis that remote pharmacological preconditioning (RPP) induced myocardial heat shock protein (Hsp) 32 expression and attenuated the ischemia-reperfusion (I/R) injury of the heart in rats. (
  • Madecassoside (MA), one of the principle terpenoids in Centella asiatica , has shown protect effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in our previous studies. (
  • The aim of this study is to investigate if MA also protected against myocardial ischemia-reperfusion injury in vivo . (
  • These results suggest that MA has the protective effect on myocardial ischemia-reperfusion injury. (
  • SUMMARY The pathogenesis of myocardial ischemia-reperfusion injury (MI/R) involves an inflammatory response in the myocardium undergoing reperfusion. (
  • Modulation of this response by splenectomy constitutes an option to protect the heart from MI/R. To mimic the effect of splenectomy in a pharmacological approach, the sphingosine-1-phosphate agonist FTY720 was applied at the onset of reperfusion. (
  • Global myocardial ischemia reperfusion (I/R), which is often obligatory during cardiac surgery, induce an inflammatory response in the transplanted heart. (
  • In Krebs-Henseleit buffer-perfused rabbit hearts, administration of ONOO − at the onset of reperfusion enhanced myocardial injury in a concentration-dependent fashion with a significant effective concentration of 30 μM. (
  • Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury. (
  • The role of Cu/Zn-superoxide dismutase (SOD) in myocardial ischemic reperfusion injury was studied by using a mouse model with targeted disruption of the mouse Sod I gene. (
  • The isolated buffer-perfused hearts from the knockout mice devoid of any functional copy of the Sod I (Sod I(-/-)) and matched nontransgenic control mice were subjected to 30 minutes of global ischemia followed by 2 hours of reperfusion. (
  • These results documented that Sod I(-/-) mouse hearts were more susceptible to ischemic reperfusion injury compared with corresponding wild-type mouse hearts, suggesting that the Sod I gene constitutes an important defense element for the hearts. (
  • Dexmedetomidine (DEX) exerts cardioprotection against ischemia/reperfusion injury. (
  • The aim of the present study was to investigate the cardioprotective mechanism of DEX pretreatment on myocardial ischemia/reperfusion (I/R) injury in diabetic rats. (
  • DEX pretreatment may exert cardioprotective effects against myocardial ischemia/reperfusion injury in diabetic rats through the I/R-induced inhibition of cell apoptosis by activating the PI3K/Akt signaling pathway. (
  • Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival. (
  • Ischemia-reperfusion (IR) tissue injury is the resultant pathology from a combination of factors, including tissue hypoxia, followed by tissue damage associated with re-oxygenation. (
  • citation needed] While some investigations suggest a possible beneficial effect of mesenchymal stem cells on heart and kidney reperfusion injury, to date, none have explored the role of stem cells in muscle tissue exposed to ischemia-reperfusion injury. (
  • The ischemia-reperfusion injury associated with surgical tourniquets is typically not clinically apparent when used for less than two hours. (
  • From the authors: "These data show that while chronic cardiac injury following [myocardial infarction] protected against acute kidney injury via activation of hypoxia-sensing pathways, it worsened chronic kidney injury. (
  • The purpose of this study is to be able to better describe the incidence, timing and severity of myocardial dysfunction and acute kidney injury (AKI) following a documented respiratory viral illness (RSV, adenovirus, metapneumovirus, parainfluenza, influenza, etc.) in pediatric patients. (
  • Viral Illness in the Pediatric Critical Care Setting: the Incidence, Timing and Severity of Associated Myocardial Dysfunction and Acute Kidney Injury. (
  • Acute Kidney Injury (AKI) as defined by the meeting of the pediatric RIFLE criteria. (
  • Children who underwent cardiac surgery were less likely to develop acute kidney injury if they had been treated with acetaminophen in the first 48 hours after their procedures, according to a Vanderbilt study just published in JAMA Pediatrics. (
  • The finding is significant because acute kidney injury is a very common problem after such surgeries, and there previously have not been any medications to treat or prevent it, said Sara Van Driest, MD, Ph.D., assistant professor of Medicine and Pediatrics, one of the study's authors. (
  • At least 5 percent of all patients who are admitted to the pediatric floor and at least 25 percent of those who require intensive care develop acute kidney injury. (
  • Among children who have cardiac surgery, about half develop acute kidney injury. (
  • This is important because those patients who have acute kidney injury are known to have increases in mortality during that hospital stay, and in morbidity, meaning that they have worse kidney function in the months and years after," Van Driest said. (
  • that acetaminophen could protect against acute kidney injury. (
  • The retrospective observational study found the lower rate of acute kidney injury in 999 pediatric surgery patients using acetaminophen, first at Vanderbilt and then at Duke University. (
  • We found that the more acetaminophen that they got, the less likely they were to have acute kidney injury," Van Driest said. (
  • Even after we took measures to adjust for how sick the patients were, how long their cardiac surgery was, and how many risk factors they had for acute kidney injury, the protective effect of acetaminophen remained. (
  • IR injury contributes to disease and mortality in a variety of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea. (
  • citation needed] Serum creatinine and BUN may be elevated in the setting of acute kidney injury. (
  • Organs involved in filtration (e.g., the kidneys and the liver), may be overwhelmed by the high load of cellular break down products, and face injury themselves (e.g., acute kidney injury). (
  • The results further our understanding of cardiorenal signaling mechanisms and have implications for the treatment of heart failure patients with associated renal disease. (
  • Cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure. (
  • Below are some of our news stories explaining the potential dangers of Actemra, and especially the connection to heart failure, stroke, pancreatitis, lung disease, and gastrointestinal perforations (holes and tears). (
  • This review discusses the role of biochemical markers of myocyte injury in patients with chronic congestive heart failure. (
  • Concentrations of these biochemical markers increase in the absence of ischaemic events in the subset of patients with heart failure whose long term outcomes are most adverse. (
  • The serial clinical use of these markers, separately or in combination, will sharpen our understanding of the state of heart failure. (
  • Chronic congestive heart failure is associated with a dismal long term prognosis and remains a major worldwide health concern. (
  • While various management strategies have become available, clinical tools to stage chronic heart failure remain few. (
  • New York Heart Association (NYHA) functional classification, along with several tests, including chest x ray, echocardiogram, myocardial scintigraphy, cardiopulmonary exercise, and haemodynamic measurements are useful to estimate the degree of heart failure, though are subject to inter-observer variations in interpretation. (
  • The loss of cardiac function in patients with chronic heart failure may be caused by ventricular remodelling, a process by which ventricular size, shape, and function are altered by mechanical, neurohormonal, and genetic factors. (
  • 3, 4 Serial measurements of reliable biochemical markers of myocyte injury in patients with heart failure would be helpful to monitor their long term progress, without inter-observer variability. (
  • This review discusses our understanding, and the significance, of current biochemical markers detected in patients with chronic heart failure. (
  • Furthermore, studies performed as long as two decades ago found no correlation between serum concentrations of CK or CK-MB and heart failure. (
  • Thus, while still in the early stages of investigation, there is evidence that recruiting this small group of stem cells to the heart could be the basis of novel therapies for halting the clinical deterioration in patients with advanced heart failure. (
  • According to researchers there has been a need for the development of interventional strategies for cardiomyopathy and preventing its progression to heart failure. (
  • Our study shows our SCF gene transfer strategy can mobilize a promising adult stem cell type to the damaged region of the heart to improve cardiac pumping function and reduce myocardial infarction sizes resulting in improved cardiac performance and potentially increase long-term survival and improve quality of life in patients at risk of progressing to heart failure," says Dr. Fish. (
  • This research study was performed in collaboration with the Celladon Corporation in San Diego, CA. Dr. Hajjar is the scientific cofounder of the company Celladon, which is developing his AAV1/SERCA2a gene therapy for the treatment of heart failure. (
  • Symptoms include angina, and that of heart failure. (
  • Heart failure remains a leading cause of morbidity and mortality worldwide, and it is projected to afflict over 8 million Americans by 2030. (
  • Signs of trouble: Postdoc Kemal Akat and colleagues used sensitive RNA sequencing techniques to profile the abundance of microRNAs in samples from healthy people and those suffering from heart failure. (
  • When we profiled the small RNAs circulating in the blood of healthy people versus heart failure patients, we found increases in levels of certain microRNAs expressed by muscle, including three known to originate only in the heart," says Kemal Akat, the first author and a postdoc in the lab. (
  • The researchers profiled the microRNA in samples of blood and heart tissue from healthy people and people suffering from one of two types of heart failure , which develops when the heart's pumping action weakens, making it unable to deliver blood throughout the body. (
  • The researchers found elevated levels of muscle-associated microRNAs in the blood but not in the heart tissue samples of the heart failure patients . (
  • Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers. (
  • The firm is also representing individuals who suffered from a stroke or congestive heart failure while taking the drug. (
  • Risk of heart failure. (
  • it was also discovered that Actos had the potential to cause heart failure. (
  • A Mayo Clinic Proceeding documented that some people who took the drug developed congestive heart failure whose hallmarks are symptoms such as edema, shortness of breath and weight gain. (
  • The U.S. Department of Health and Human Services (HHS) took the death-rate data of the thousands of U.S. hospitals regarding hearth attacks and heart failure and posted it on their website today as part of an ongoing effort to give Americans information about which U.S. hospitals provide the best healthcare. (
  • The new information tracks 30-day mortality after heart failure or heart attack, with adjustments for patients' age, health and other factors, making it possible to compare the cardiac-care performance of 4,500 different acute-care hospitals. (
  • Regarding the heart failure mortality data, 35 hospitals scored a below-average rating, and only 38 hospitals scored an above-average rating. (
  • Have you been treated for heart failure or a heart attack at a hospital, with substandard results? (
  • This study aims to investigate the risk of heart failure (HF) in patients with malignant LVH and myocardial injury. (
  • The prevalence of heart failure in this population was studied. (
  • The heart can recover from myocarditis, but in rare cases, the condition can damage the heart muscle enough to lead to heart failure. (
  • Onglyza is the latest medication to catch the attention of the FDA after recent studies have exposed a possible link between its use and increased likelihood of heart failure and the development of pancreatic cancer. (
  • Studies have shown that patients using Onglyza were 27% more likely to experience heart failure but no conclusive evidence directly linked the medication to heart attack, stroke or other cardiovascular diseases. (
  • If you were prescribed Onglyza for the treatment of diabetes and experienced severe side effects such as cardiovascular disease, heart failure, the development of tumors or pancreatic cancer, you may be entitled to compensation for the cost of medical care, pain and suffering and any additional financial losses you may be forced to incur in the present or the future. (
  • One of the best indicators of a baby's status during delivery is the fetal heart rate and failure to properly monitor or respond to an abnormal heart rate can cause or exacerbate any birth injuries. (
  • Rosenfeld Injury Lawyers LLC specialize in representing the families of children who have been affected by medical malpractice and negligence-- including the failure to monitor a babies heart rate. (
  • Acute heart failure (AHF) has been defined as new-onset or worsening heart failure (HF) signs and symptoms requiring urgent therapy. (
  • Once heralded as the biggest breakthrough in diabetes treatment since insulin, patients using the drug face higher than normal risks of developing heart failure, and/or pancreatic cancer. (
  • In 2013, the Journal of the American Medical Association, JAMA, reported serious increased risks of pancreatic cancer, and a study was released showing users of the drug were more likely to be hospitalized for heart failure. (
  • The New England Journal of Medicine published results of a study of over 16,000 patients, showing that patients using Onglyza were nearly 30% more likely to be hospitalized for heart failure, than diabetes patients not using the drug. (
  • The FDA investigation concluded in 2015 with the requirement that AstraZenica place a warning label of increased risk of heart failure on the drug in addition to the warning of pancreatitis that it had previously required. (
  • In 2015, a lawsuit was filed by the daughter of a deceased patient who began using the drug in 2010, and died of complications from heart failure in 2013. (
  • If death occurs it is typically from either an abnormal heart rhythm or respiratory failure. (
  • In the study, Mount Sinai researchers administered stem cell factor (SCF) by gene transfer shortly after inducing heart attacks in pre-clinical models directly into damaged heart tissue to test its regenerative repair response. (
  • There are some problems and issues associated with the use of stem cells to treat heart attacks and blocked arteries in the heart, and with this new method, many of these issues are removed. (
  • Potentially, we may have an important way to treat heart attacks. (
  • People who were exposed to the dust cloud or sustained physical injuries during the terrorist attacks on the World Trade Centre on September 11, 2001 may be at increased long-term risk of asthma, other respiratory diseases, and heart attack, according to a study published in the open access journal Injury Epidemiology . (
  • Although many people die from heart attacks , there are also many cases where people fear that they have a heart attack, but actually have something milder. (
  • The wide-ranging reports of injuries among young Juul users include strokes and heart attacks as well as other deadly reactions like pneumonia and inhalation disorders. (
  • The researchers will investigate new markers found in the blood, microRNAs, to identify those that may diagnose heart attacks more rapidly, and therefore improve patient care. (
  • The molecule CXCL12 is an important signal during embryonic development of arterial cells, and has been shown to improve cardiac recovery and function after heart attacks. (
  • After inducing heart attacks in adult mice, they injected CXCL12 into the injured areas. (
  • According to a recent study, testosterone products double the risk of heart attacks in some men. (
  • That study was halted due to the number of heart attacks and strokes. (
  • The U.S. Food and Drug Administration (FDA) announced a recommendation that manufacturers developing type 2 diabetes drugs offer evidence that new therapies will not increase the risk of cardiovascular episodes such as heart attacks. (
  • To determine if aldose reductase inhibition improves tolerance to ischemia, hearts from acute type I diabetic and nondiabetic control rats were isolated and retrograde perfused. (
  • Recent studies also identified amylin deposits in failing hearts from patients with obesity or type 2 diabetes and demonstrated that hyperamylinemia accelerates the development of heart dysfunction in rats expressing human amylin in pancreatic β-cells (HIP rats). (
  • Neonatal LPS exposure showed no effects on the baseline heart function determined by in vivo and ex vivo experiments, but caused decreases in the post-ischemic recovery of the LV function in male but not female rats. (
  • The dams were allowed to give nature delivery and then heart tissues from weaned (postnatal day 21) offspring rats were analyzed for mitochondrial injury through ultrastructure observation by electron microscope, global gene expression profile by microarray, as well as related mRNA and proteins expression levels by quantitative PCR and western blot. (
  • Angiotensin II type 2 receptor ligand PD123319 attenuates hyperoxia-induced lung and heart injury at a low dose in newborn rats. (
  • At low concentrations PD123319 attenuates cardiopulmonary injury by reducing pulmonary inflammation and fibrosis and preventing PAH-induced RVH but does not affect alveolar and vascular development in newborn rats with experimental BPD. (
  • RPP significantly decreased the duration of arrhythmia and incidence of stony heart in rats with subsequent I/R injury. (
  • Following a FPI or sham injury, rats were exercised with forced (fRW) or voluntary (vRW) running wheels on post-injury days 0-4 and 7-11. (
  • 0.05) the severity of heart injury in the rats underwent transplant procedure. (
  • Cardiac injury leads to significant structural changes in the heart, including enlargement, excess formation of fibrous growth tissue, and abnormalities of the coronary vasculature. (
  • In addition to differences in regenerative capacity, the investigators also found an indicator of tissue fibrosis or "scarring", profibrotic marker PAI-1, was markedly elevated only after transmural injury. (
  • Total white blood cell (WBCs), platelets, and cytokines pathological changes of heart tissue were also examined. (
  • In addition, DBD significantly alleviated pathological changes of heart tissue. (
  • Delivering stem cell factor directly into damaged heart muscle after a heart attack may help repair and regenerate injured tissue, according to a study led by researchers from Icahn School of Medicine at Mount Sinai presented November 18 at the American Heart Association Scientific Sessions 2014 in Chicago, IL. (
  • In addition, the gene therapy improved cardiac function, decreased heart muscle cell death, increased regeneration of heart tissue blood vessels, and reduced the formation of heart tissue scarring. (
  • Researchers have revealed that experiments on pigs have shown that secretion from human embryonic stem cells can minimize heart injury by reducing tissue death by 60 per cent. (
  • Ex vivo perfusion for preservation of donor hearts may be improved by preventing inflammatory tissue injury, including through mechanical work. (
  • Inflammation response then concurs to increased extent of tissue injury during I/R. Besides enhancement of inflammation, ROS causes mitochondrial depolarization and prolonged opening of mitochondrial permeability transition pore, triggering cell apoptosis [ 6 ]. (
  • Ex situ heart perfusion (ESHP) is an emergent technique that allows for continued perfusion of the beating heart, supplying required oxygen and nutrients, which may better preserve the tissue. (
  • Yet, organ function continues to decline throughout ESHP, possibly due to inflammatory tissue injury. (
  • Interestingly, the hearts operating in WM expressed reduced biomarkers of inflammation when compared to the NWM group, and expression was comparable with that observed in freshly harvested tissue, which had not experienced ESHP. (
  • The exact mechanisms underlying preservation of heart function in WM have yet to be fully elucidated, but the results indicate that inflammation is a critical driver of acute tissue damage attenuated under these conditions. (
  • Moreover, it highlights the involvement of inflammatory tissue injury in functional decline of perfused hearts. (
  • For this reason, we suspect microRNAs may be more readily released into circulation and their levels may increase faster than cardiac troponin upon tissue injury," Akat says. (
  • Nitric oxide (NO) is known to act as a mediator of tissue injury as well as being a potent endogenous vasodilator. (
  • Overuse injuries occur when too much stress is placed on a joint or other tissue, often by "overdoing" an activity or repeating the same activity. (
  • Silent brain infarction is a brain injury likely caused by a blood clot interrupting blood flow to brain tissue. (
  • The up-regulation of gene transcripts encoding for uncoupling proteins (UCP1 and UCP3), epidermal growth factor receptor (EGFR) and connective tissue growth factor (CTGF), was probably a protective process to maintain heart function. (
  • It's more difficult to interpret whether these changes in the heart tissue are due to coronavirus infection, says Saurabh Rajpal, a cardiologist at the Ohio State University Wexner Medical Center in Columbus. (
  • Administration of ONOO − decreased neutrophil accumulation in the ischemic-reperfused myocardial tissue in a concentration-dependent manner in blood-perfused hearts and inhibited neutrophil adhesion to cultured endothelial cells exposed to hypoxia/reoxygenation. (
  • This compound is directly toxic to the cardiac tissue at a relatively high concentration, but it can indirectly protect myocardial cells from neutrophil-induced injury at a much lower concentration. (
  • Through advanced imaging that let them look at the intact newborn hearts at the cellular level, the researchers showed that this happened because arterial endothelial cells exited the artery, migrated along existing capillaries that extended into injured heart tissue and reassembled to form collateral arteries. (
  • The scientists wondered if this molecule had a beneficial effect by promoting collateral artery growth in injured heart tissue. (
  • Next they investigated whether CXCL12 could help adult heart tissue grow collateral arteries. (
  • The TigerPaw System has been recalled after reports of heart tissue tears and severe bleeding. (
  • citation needed] Systemic effects of IR injury During periods of ischemia, cellular break down products accumulate in the local tissue. (
  • MiR322 is known to coax stem cells to make heart cells during development but is typically found at a lower, more basal level and with an unclear purpose in the adult heart, says Dr. Yaoliang Tang, cardiovascular researcher in the Vascular Biology Center and Department of Medicine at the Medical College of Georgia at Augusta University. (
  • Objective Troponin and high signal intensity on T2-weighted (HighT2) cardiovascular magnetic resonance imaging (CMRi) are both markers of myocardial injury in hypertrophic cardiomyopathy (HCM). (
  • Our discoveries offer insight into the power of stem cells to regenerate damaged muscle after a heart attack," says lead study author Kenneth Fish, PhD, Director of the Cardiology Laboratory for Translational Research, Cardiovascular Research Center, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai. (
  • It is clear that the expression of the stem cell factor gene results in the generation of specific signals to neighboring cells in the damaged heart resulting in improved outcomes at the molecular, cellular, and organ level," says Roger J. Hajjar, MD, senior study author and Director of the Cardiovascular Research Center at Mount Sinai. (
  • Myocardial injury induced by I/R accounts for the majority of death induced by various forms of cardiovascular diseases [ 1 ]. (
  • In fact, it has been reported that cardiovascular diseases are the leading cause of death for persons with a spinal cord injury of more than 30 years and for those people with SCI who are more than 60 years of age (Whiteneck). (
  • Recent studies by Bauman and Spungen demonstrated that people with a spinal cord injury who were less fit on a cardiovascular test were more likely to be insulin resistant. (
  • People with spinal cord injury must use appropriate prevention strategies to reduce the risk of developing cardiovascular disease. (
  • But testosterone therapy has been linked to an increased risk of cardiovascular injuries in some male patients. (
  • If you or someone you love suffered a clotting injury or developed a cardiovascular illness after using a testosterone replacement therapy product, you may be entitled to compensation for your damages. (
  • From publicly available information, Cleveland Clinic cardiologist Dr. Steven Nissen and his colleague Kathy Wolski, found, after evaluating 42 studies that compared patients taking Avandia with patients not using the drug, that the risk of heart attack increased 43 percent among patients taking Avandia and determined that there is also a 64 percent increased risk of dying from cardiovascular causes while taking Avandia. (
  • If you or someone you know is addicted to Juul products, or has suffered a serious cardiovascular injury you believe may relate to Juul e-cigarettes, we urge you to contact us today about your case . (
  • An understanding of the internal link between type 2 diabetes and cardiovascular injury may help identifying novel therapies alleviating ischemic myocardial injury to reduce cardiovascular morbidity and mortality. (
  • Cardiovascular disease (is) occurring in people with spinal chord injuries at a young age and at higher rates than able-bodied individuals. (
  • The following news briefs summarize their presentations of research in congenital heart disease (CHD). (
  • Pre-operative Cerebral Hemodynamics from Birth Until Surgery in Infants with Critical Congenital Heart Disease [abstract 1007, Thurs., Feb. 12. (
  • Brain Injury in Neonates with Complex Congenital Heart Disease: What Is the Predictive Value of MRI in the Fetal Period? (
  • Using cryoinjury - damaging the heart through exposure to extreme cold in order to mimic cellular injury caused by myocardial infarction - investigators found that neonatal mouse hearts can fully recover normal function following a mild injury, though fail to regenerate after a severe injury. (
  • Severe, or transmural injury, is associated with a blood supply blockage to the full thickness of the heart. (
  • The heart undergoes changes after spinal cord injury that are dependent on how severe the spinal cord injury is but only a small amount of "sparing" (i.e., a small number of nerve fibers preserved) in the spinal cord are necessary for the heart to function at a near normal level. (
  • Although the most severe symptoms of heart attack are hard to miss, there are varying degrees of severity. (
  • Until recently, however, it was believed that most cases of cardiac damage were fatal, and that they occurred only in severe, penetrating chest injuries. (
  • In the past two decades, however, and particularly with the advent of electrocardiography, numerous clinical and experimental studies have demonstrated that many cases of severe cardiac damage, including rupture of the heart, result from non-penetrating chest injuries, although the thoracic cage remains intact without as much as a fractured rib. (
  • People with heart disease or a history of stroke are at increased risk of the coronavirus infection, and of suffering more severe symptoms, according to the American Heart Association (AHA). (
  • When it fires out of control -- a severe inflammatory reaction known as a cytokine storm -- it can damage organs throughout the body, including the heart. (
  • Among 416 patients hospitalized for severe COVID-19, about 20% suffered a heart injury. (
  • Increasing evidence suggests that many individuals who experienced these problems may have avoided severe and life-threatening injuries if Novartis had adequately researched their medication and provided information about these known risks to users in the United States. (
  • This article describes a study using heart rate variability (HRV) biofeedback to treat emotional dysregulation in 13 individuals with severe chronic brain injury. (
  • Results demonstrated that individuals with severe brain injury were able to learn HRV biofeedback and increase coherence between the parasympathetic and sympathetic nervous systems. (
  • Patients with type 2 diabetes have increased risk of developing ischemic heart disease and more severe and fatal myocardial infarctions than nondiabetic population [1, 2]. (
  • Participants were drawn from AHRC, a community-based structured day program in New York City that provides long-term rehabilitation services for individuals with severe brain injuries who are past the post-acute phase of rehabilitation. (
  • Evidence is also presented that even individuals who sustained severe brain injuries and are long past the post-acute phase of rehabilitation can learn new techniques, respond to biofeedback, and greatly increase coherence in heart rate variability. (
  • Contact our drug injury lawyers today, and let us protect your legal rights. (
  • Our drug injury lawyers can help you get the money you need for your medical bills, lost wages, and pain and suffering. (
  • For more information about Avandia or to find out more about your legal rights, please visit . (
  • The lawyers at Saiontz & Kirk, P.A. are reviewing potential Tasigna lawsuits for individuals who have suffered a heart attack, stroke or other injuries that may have been caused by arteriosclerosis , which involves a narrowing and hardening of the arteries that may result from side effects of the leukemia treatment. (
  • Rosenfeld Injury Lawyers LLC is no longer accepting these type of cases. (
  • Rosenfeld Injury Lawyers LLC is a leader in the field of pharmaceutical litigation. (
  • The Rosenfeld Injury Lawyers LLC are always committed to representing those who have been harmed due to others' negligence and our experienced attorneys would be happy to discuss your case with you during a free consultation. (
  • If you feel that the injuries your child sustained during birth were the result of negligence or malpractice, contact the birth injury attorneys at Rosenfeld Injury Lawyers LLC today to schedule a free consultation with a personal injury attorney who will evaluate the details of your case and answer any questions you may have. (
  • Our lawyers are located throughout Illinois and have a successful track record handling birth injury cases. (
  • Our team of product liability lawyers is currently accepting cases of serious injury and death from dangerous, defective, and recalled products. (
  • However solutions, including cardiac bypass surgery and angioplasty to reopen blocked coronary arteries, can result in a second period of adjustment and injury that can be responsible for as much as half of the size of the damage done to the heart muscle, called the infarct size. (
  • This study compared a goal-directed cardiopulmonary resuscitation (CPR) method using a hemodynamic coronary perfusion pressure (CPP) target to the American Heart Association's CPR Guideline that targets depth of chest compressions. (
  • Recent research studies have found that people with spinal cord injury have an increased risk of developing coronary heart disease (CHD) at an earlier age than in the non-disabled population. (
  • Baum Hedlund Aristei & Goldman's drug department is representing many individuals who were taking Avandia and suffered a heart attack or coronary artery blockage that required a stent or bypass surgery. (
  • Our firm is investigating harrowing reports of strokes, heart and other coronary diseases, and seizures alleged to be related to vape use, as well as inhalation injury, inhalation pneumonitis and toxic inhalation pneumonitis, and pneumonia. (
  • The coronary flow was lower compared with the baseline levels for both groups of hearts, but there was no significant difference between the groups. (
  • While rejuvenation research aims at a world in which no-one ever suffers coronary artery disease or a heart attack , the causes of those conditions prevented and controlled, we still live in a world in which these conditions are accepted as inevitable, and the near term focus of regenerative medicine is structural repair for the survivors after the fact. (
  • Cardiac enzymes have long been used as frontline diagnostic tools in the detection of myocardial injury caused by myocardial ischaemia. (
  • Heart disease and stroke statistics-2015 update: a report from the American Heart Association. (
  • A study published in The Journal of the American Medical Association reports a 30 percent increase in the risk of heart attack, stroke, pulmonary embolism, DVT, and even death in men who take these drugs. (
  • But if you or your husband, son, father, or other loved one suffered a heart attack, stroke, or other clotting injury after taking testosterone-boosting products, the drug's manufacturer may be to blame. (
  • If you or someone you love suffered a heart attack or stroke while receiving testosterone replacement therapy (TRT), you may be able to recover compensation for your injuries. (
  • The FDA announced in January, 2014, that it is investigating the risk of stroke, heart attack, and death in men using TRT products. (
  • The first study, published in the Journal of the American Medical Association (JAMA) in November 2013, observed older men in the U.S. Veteran Affairs health system, and found a 30% increased risk of stroke, heart attack, and death in those who were taking TRT. (
  • If you have suffered a heart attack or stroke while taking a testosterone product, or if you have lost someone who was taking testosterone, you may be able to recover significant compensation. (
  • Chest Heart & Stroke Scotland is a wholly Scottish charity. (
  • Diseases such as muscular dystrophy, stroke, heart and lung disease will all be studied. (
  • Researchers in that study found that the men who used testosterone supplements had nearly a 30 percent increased risk of stroke, heart attack and death. (
  • If you or a loved one suffered a heart attack, stroke or death following use of a testosterone product, you may be entitled to compensation. (
  • Patients who recovered from acute kidney injuries were 67 percent more likely to have heart problems or die during the study period, whether or not they developed chronic kidney disease , according to a journal news release. (
  • Heart disease is the leading cause of death in Georgia and the United States, according to the Centers for Disease Control and Prevention. (
  • Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges. (
  • Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease. (
  • The activation of NF-кB would conduce to the productions of inflammatory cytokines and the modulations of other biochemical indices of heart disease such as LDH and CK [ 9 ]. (
  • HighT2 on CMRi may identify a group of particularly vulnerable patients, supporting the concept that HighT2 reflects an active disease state, prone to additional injury after a short episode of high oxygen demand. (
  • Heart disease is the number one cause of death in the United States, with cardiomyopathy or an enlarged heart from heart attack or poor blood supply due to clogged arteries being the most common causes of the condition. (
  • Conclusion- Pharmacological soluble guanylate cyclase activation could be a novel approach for the prevention and treatment of ischemic heart disease. (
  • This is important as individuals with spinal cord injury are at a much higher risk for heart disease than people without spinal cord injury. (
  • Researchers at the New York City Department of Health and Mental Hygiene examined the association between physical injury or acute exposure to the dust cloud on the morning of September 11, 2001, and chronic disease up to ten to eleven years later (2010-2012). (
  • The researchers found 92 incident cases of heart disease, 327 new cases of diabetes, 308 cases of asthma, and 297 cases of non-neoplastic lung disease among 7,503 area workers, 249 rescue workers, 131 residents and 818 passersby -- the most heavily exposed groups. (
  • Insulin resistance results in multiple metabolic and blood pressure abnormalities that can increase the risk of developing the atherosclerotic-type of heart disease. (
  • These results are consistent with the pathological role of amylin deposition in the pancreas, uncover a novel contributing mechanism to cardiac myocyte injury in type 2 diabetes, and suggest a potentially treatable link of type 2 diabetes with diabetic heart disease. (
  • However, recent studies ( 5 - 10 ) found amylin deposition in failing kidneys ( 5 ) and hearts ( 6 , 7 ) from patients with type 2 diabetes, and in the brains ( 8 - 10 ) of patients with diabetes who have Alzheimer's disease. (
  • In the heart, significant amylin deposits were identified in areas of cardiac myocyte injury ( 6 , 7 ) and in myocyte lysates ( 7 ), suggesting a role in the pathogenesis of diabetic heart disease. (
  • The risk of heart attack also doubles for men under age 65 if they have a history of heart disease. (
  • The same study also concludes that, compared to "Low T" drugs, erectile dysfunction drugs-also marketed as methods to increase male sexual performance-are much less likely to increase the risk of heart attack in men under age 65 who have a history of heart disease. (
  • In this study, we detected and analyzed the main laboratory indicators related to heart injury, creatine kinase isoenzyme-MB (CK-MB), myohemoglobin (MYO), cardiac troponin I (ultra-TnI), and N-terminal pro-brain natriuretic peptide (NT-proBNP), in 273 patients with COVID-19 and investigated the correlation between heart injury and severity of the disease. (
  • Indirectly, he explained, the overall stress of being critically ill -- with lung disease that is robbing the body of oxygen -- can exact a toll on people with existing heart problems. (
  • For the most part, the complications have struck people with established heart disease or risk factors for it, such as high blood pressure. (
  • It's critical that no one -- especially people with known heart disease -- ignore symptoms, said Dr. J. Wells Askew, a cardiologist at the Mayo Clinic in Rochester, Minn. (
  • It also found that in men under 65 who had a pre-existing history of heart disease, experienced a two to three-fold increased risk of heart attack within the first 90 days of filling their prescription. (
  • Ischemic heart disease is also prevailing in the aged people. (
  • Heart disease is their No. 1 killer and Dr. Andrei Krassioukov , a principal investigator at the ICORD spinal injury centre, which is supported by UBC and Vancouver Coastal Health, will lead a team of 20 scientists, clinicians and health-care advocates in examining the best ways to shrink the number of fatalities. (
  • Postexercise Systolic Blood Pressure Response: Clinical Application to the Assessment of Ischemic Heart Disease. (
  • Presents information on the clinical application of postexercise systolic blood pressure response in the assessment of ischemic heart disease. (
  • If additional studies performed by the FDA give credence current allegations, AstraZeneca, the maker of Onglyza may be held accountable to all those who have taken the medication and suffered from heart disease or developed cancers related to the medication. (
  • Three projects are directly supporting early stage cell-therapy clinical trials in multiple myeloma, type 1 diabetes and heart disease. (
  • In men who have a history of heart disease, the risk is tripled. (
  • Diabetics are two-to-four times more likely to suffer from heart disease than non-diabetics. (
  • Because those patients afflicted with diabetes often require life-long treatment, the FDA feels that patients and prescribers need to know more about whether therapies to treat the disease put patients at an increased risk of a heart attack. (
  • Brain injury is one of the most unacceptable complications sustained during heart surgery. (
  • Many patients are developing heart complications, though the reasons are not fully understood. (
  • How common are heart complications? (
  • It's hard to say what the percentages are," he said, "but a similar spectrum [of heart complications] is being seen. (
  • When the device is designed or manufactured improperly, or if the approval process was flawed, patients can be subject to serious injury or even death from complications. (
  • A) Isolated C57Bl/6 mouse hearts were treated with A-769662 (100 μmol/L) or vehicle for 30 min of aerobic perfusion. (
  • First, it indicates that perfusion in the working state may provide longer-lasting donor heart preservation, thus improving the technology's ability to expand the donor organ pool. (
  • The present experiment was designed to determine whether ONOO − may exert different effects on postischemic myocardial injury in a crystalloid perfusion environment versus a blood perfusion environment and, if it does, to clarify the mechanisms causing any differences. (
  • When they increased miR322 by giving what scientists call its mimic, they saw levels of the endogenous heart cell protector Notch 1 significantly increase while levels of cell suicide promoter FBXW7 significantly decreased, and heart damage reduced. (
  • Within 48 hours after injury, the left ventricular free wall and septum were significantly enlarged, with an increase in heart weight and relative wall thickness compared to controls. (
  • In both models post-injury, the cells that form heart muscle, cardiomyocytes, did not increase significantly. (
  • Myocardial infarct size (percentage of total heart weight +/- SEM) did not significantly differ between MRL and C57/Bl6 controls (18.9 +/- 1.8% for MRL vs. 15.7 + 1.3% for C57/Bl6, p = 0.20). (
  • CP was administrated daily by gavage for six days at 0.1, 0.4, and 0.8 g/kg/day before I/R. Results showed that multiple dosing of CP at three doses significantly reduced I/R-induced myocardial injury, microcirculatory disturbance, and oxidative stress. (
  • The research concluded that African-American patients with LVH and myocardial injury were at a significantly higher risk of HF. (
  • Cardiac functions, myocardial infarct size, myocardial ATP and NAD(+) contents, mitochondrial ultrastructure, and anti-apototic and anti-oncosis protein levels were measured.Results:Sevoflurane post-conditioning significantly improved the heart function, decreased infarct size and mitochondria damage, and increased myocardial ATP and NAD(+) content in the I/R hearts. (
  • Furthermore, sevoflurane post-conditioning significantly increased the levels of p-ERK and p-p70S6K, decreased the levels of porimin, caspase-8, cleaved caspase-3, and cytosolic cytochrome c in the I/R hearts. (
  • In contrast, in blood-perfused hearts, administration of ONOO − (1 to 30 μM) significantly attenuated postmyocardial injury as evidenced by improved cardiac function recovery, preserved endothelial function, decreased myocardial creatine kinase loss, and reduced necrotic size. (
  • So Tang's team began looking for the source of miR322 in adult hearts -- which turned out to be the endothelial cells that line the blood vessels -- and in the process they also found miR322's target. (
  • Inspired by the ability of platelets to recruit stem cells to sites of injury on blood vessels, we hypothesized that platelets might enhance the vascular delivery of cardiac stem cells (CSCs) to sites of myocardial infarction injury. (
  • However, responses to cardiac injury repair in the outer layer of the heart (epicardium) and blood vessels (revascularization) - were present. (
  • It's thought that the infection may sometimes directly damage blood vessels, which can cause blood clots that lead to a heart attack. (
  • In this case, in which researchers provoke greater construction of secondary arteries that can support the primary blood vessels of the heart, capable of supplying blood when the primary is damaged, one may ask whether it can also be a means of reducing the impact of structural damage if applied well in advance. (
  • The injuries were apparently due to the outside coating detaching from the guidewires, which blocked blood vessels, preventing blood from entering the heart. (
  • Most of the time our body movements do not cause problems, but it's not surprising that symptoms develop from everyday wear and tear, overuse, or an injury. (
  • Most minor injuries will heal on their own, and home treatment is usually all that is needed to relieve symptoms and promote healing. (
  • In addition to pain and tenderness, common symptoms of tendon injury include decreased strength and movement in the affected area. (
  • Twelve of the 26, including two of the four with signs of inflamed hearts, reported mild symptoms during their infection, such as fever, sore throat, muscle aches and difficulty breathing. (
  • For now, the results suggest the heart may be at risk of injury, and serve as a reminder that after having COVID-19 - even with mild or no symptoms - young people need to pay close attention to how they are feeling when they return to exercise, says Rajpal. (
  • If they have symptoms like chest pain, shortness of breath or an abnormal heart beat, he says, they should see a doctor. (
  • Cardiac MRI usually is used to confirm a diagnosis of myocarditis in combination with other clinical signs, including symptoms, blood test results that signal inflammation, high levels of a protein called troponin I that indicates stress on the heart and abnormal findings in an electrocardiogram. (
  • At present, Everett said, doctors have to wait years for some brain injury-related symptoms to appear. (
  • Initial symptoms may include heart asystole and respiratory arrest. (
  • Other symptoms may include burns and blunt injuries. (
  • This similarity, as well as other evidence, suggests microRNAs could also serve as biomarkers for heart injury, and the researchers hope microRNAs could even have an advantage over cardiac troponin. (
  • This opens the possibility of finding many promising biomarkers like those we found from heart muscle , leading to a more universal test then the current monitoring of single proteins. (
  • We hypothesized that limb remote ischemic preconditioning (RIPC) would reduce intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.The primary outcomes included the biomarkers reflecting intestinal injury (serum intestinal fatty acid binding protein, endotoxin levels and diamine oxidase activity) and the variables reflecting pulmonary injury (arterial-alveolar oxygen tension ratio, alveolar-arterial oxygen tension difference and respiratory index). (
  • The project originated about two years ago when Katz, who chairs the Department of Materials Science and Engineering, was contacted by Allen D. Everett, a Johns Hopkins Children's Center pediatric cardiologist who studies biomarkers linked to pulmonary hypertension and brain injury. (
  • A recent study showed that biomarkers in mothers' and babies' blood may be the key to providing doctors with information they need to identify newborns who are at increased risk for brain injury following cardiac surgery. (
  • Read more about Deaths and Heart injury . (
  • FDA Reveals Criminal Probe of E-Cigarette Deaths & Injuries. (
  • It is estimated that lightning injuries occur 240,000 times a year with 24,000 deaths. (
  • The subject has had previous kidney injury or myocardial dysfunction prior to positive respiratory viral swab. (
  • We tested the hypothesis that neonatal exposure to lipopolysaccharide (LPS) does not alter heart function at rest condition but causes heart dysfunction under stress stimulation later in life. (
  • Xenobiotics exposure in early life may have adverse effects on animals' development through mitochondrial injury or dysfunction. (
  • The investigators induced heart injury in mice through transverse aortic constriction (TAC). (
  • Using models such as zebrafish and neonatal mice that regenerate their hearts naturally, we can begin to identify important molecules that enhance heart repair," said Ellen Lien, PhD, of The Saban Research Institute of Children's Hospital Los Angeles. (
  • Newborn mice have shown the capacity for heart regeneration, but it is rapidly lost by seven days after birth. (
  • In this experiment, we studied the effects of the Dangguibuxue decoction (DBD) on the myocardial injury induced by cyclophosphamide in mice. (
  • In summary, DBD can be considered an effective drug to alleviate CTX-induced heart damage in mice. (
  • There was no evidence of resistance to cardiac injury or of reduced scar formation in the MRL mice compared to C57/Bl6 controls. (
  • In the study, researchers from Jilin Agricultural University in China investigated the effects of baicalein on acetaminophen-exposed mice with liver injuries. (
  • We recently reported chronic neuropathic pain attenuates cardiac IR injury in mice. (
  • Researchers here make a most interesting discovery, finding that in mice there are populations of macrophages capable of coordinating greater than normal regeneration following injury to the heart, such as that resulting from a heart attack . (
  • Inactivation of the functional mouse Sod I gene in hearts by gene targeting (Sod I(+/-)) resulted in a 50% reduction of Cu/Zn-SOD mRNA and significant reduction of Cu/Zn-SOD enzyme activity compared with that of wild-type Sod I(+/+) mice. (
  • For both groups of mice, the postischemic functional recovery for the hearts was lower than the baseline, but the recovery for the Sod I(-/-) was less compared with the wild-type mice. (
  • In concert, a reduced amount of oxidative stress was found in the hearts of wild-type mice compared with Sod I(-/-) mouse hearts. (
  • In newborn mice with heart injuries, it shows up in the capillaries of the injured area. (
  • THURSDAY, Feb. 6, 2014 (HealthDay News) -- People who suffer acute kidney damage due to surgery are at increased risk for developing heart problems. (
  • But further research is required to confirm and learn more about the link between acute kidney injuries and an increased risk of heart problems, they said. (
  • Recent research in infants with critical CHD has shown that a longer period between birth and surgery increases the risk of injury to the brain's white matter, a condition called periventricular leukomalacia (PVL). (
  • While the injury will put off some sides, at a cost of £450,000 in compensation to free him from Hearts, he'll still be a risk worth taking for Championship clubs down south. (
  • The researchers found that the number of types of injuries, such as fractures, head injuries, or sprains, a person sustained on 11th September 2001 was associated with an increased risk of angina or heart attack in a dose-dependent manner, which means that the risk of having angina or a heart attack increased with every additional injury type. (
  • However, previous research has shown that more than one type of injury is associated with increased risk of death and longer stays in hospital, according to the authors. (
  • Contributing to the metabolic abnormalities are certain physical changes associated with spinal cord injury that increase the risk of CHD development. (
  • This presentation will discuss how Heart Rate Variability technology can be used to indicate and identify athlete injury risk and track well-being. (
  • This observational study, reported by researchers from UCLA, NCI, and Consolidated Research, Inc., found that men 65 and older who filled a TRT prescription were at double the risk for heart attack within three months than those who did not. (
  • Sports that require weight-bearing on the hands and arms, such as gymnastics, can increase the risk for injury. (
  • Sports that use hand equipment such as ski poles, hockey or lacrosse sticks, or racquets also increase the risk of injury. (
  • Older adults are at higher risk for injuries and fractures because they lose muscle mass and bone strength as they age. (
  • They also have more problems with vision and balance, which increases their risk of accidental injury. (
  • The primary outcome of the study was an adjusted association between LVH, subclinical myocardial injury, and the risk of incident HF hospitalization. (
  • Adjusted analyses suggested that higher LV mass and subclinical myocardial injury had independent linear associations with the risk of HF. (
  • The highest risk of HF was reported in patients with both LVH and myocardial injury (absolute incidence 35%, aHR 5.35). (
  • The findings also suggested that men with LVH and myocardial injury were at a 15-fold higher risk of HF than those with no LVH or myocardial injuries, compared to the 4-fold risk in women. (
  • Ischemic silent brain infarctions are symptomless brain injuries and are a risk factor for future strokes. (
  • Sometimes called " silent strokes ," these injuries are symptomless and are a risk factor for future strokes. (
  • The memo clearly stated that the risk of dialysis heart injury and cardiac arrest was perhaps eight times greater with GranuFlo than with other dialysates. (
  • Dr. Weissman said "It is interesting that S-100B and NSE seem to be helpful predictors of brain injury risk. (
  • Currently, diagnosis of a heart attack requires a blood test taken 12 hours after the onset of chest pain. (
  • Urban said that a TBI diagnosis doesn't automatically qualify a service member for a Purple Heart. (
  • Early diagnosis of brain injury is critical in delivering a timely intervention," says Barbara Weissman, MD, associate professor of pediatrics at Emory University School of Medicine and pediatric neurologist at Emory-Children's Center and Children's Healthcare of Atlanta. (
  • Diagnosis is typically based on history of the injury and examination. (
  • We also find that the modified CSCs selectively bind collagen-coated surfaces and endothelium-denuded rat aortas, and that in rat and porcine models of acute myocardial infarction the modified CSCs increase retention in the heart and reduce infarct size. (
  • After 17 hours, histopathological observations and left ventricular pressure-volume analysis to assess cardiac function with a Millar microtip pressure-volume conductance catheter were performed, and levels of biochemicals of the heart tissues were measured. (
  • Patients sometimes suffer acute kidney injuries after major surgery because the kidneys can be deprived of blood flow during the operation, according to background information in the study. (
  • For the research, scientists looked at data from thousands of hospitalized patients who recovered from acute kidney injuries that required dialysis . (
  • They compared these patients to a group of hospitalized patients without acute injuries using data collected from patients in Taiwan between 1999 and 2008. (
  • The findings suggest that proper monitoring and treatment of patients with acute kidney injuries could help protect their heart health, researcher Dr. Vin-Cent Wu, of the National Taiwan University Hospital, said in the news release. (
  • Pre-exercise CMRi was performed in patients with HCM to assess measures of hypertrophy and myocardial injury. (
  • Comparing patients with HCM with and without a postexercise troponin rise, maximum heart rates (157±19 vs 143±23, p=0.004) and maximal wall thickness (20 mm vs 17 mm, p=0.023) were higher in the former, as was the presence of late gadolinium enhancement (85% vs 57%, p=0.02). (
  • Another study of more than 55,000 male patients reveals that men over age 65 are twice as likely to have a heart attack after taking "Low T" drugs for as little as three months. (
  • A heart transplant is the only curative option for these patients, and preservation of precious donor organs for transplant is of critical importance. (
  • To investigate whether limb remote ischemic preconditioning (LRIP) has protective effects against intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair. (
  • Askew acknowledged that when those patients arrive at the hospital, it can be difficult to know if it's a heart attack or COVID-19. (
  • These patients got varying degrees of heart muscle injury following clearly defined surgical intervention. (
  • Dangerously high levels of sodium often cause heart problems, and hundreds of patients have alleged serious injuries after being treated with GranuFlo. (
  • It's been apparent since early in the pandemic that COVID-19 can be worse in patients who already have heart problems (SN: 3/20/20). (
  • Cardiac MRIs revealed signs of heart inflammation in 60 of these patients after their infection. (
  • Those signals of heart inflammation could mean that the patients had developed myocarditis, which is estimated to occur in approximately 22 out of 100,000 people annually around the world. (
  • As brain injury can occur with heart surgery in both adults and children, the biosensor Everett proposed should work on patients of all ages. (
  • Many of our young patients need one or more heart surgeries to correct congenital heart defects, and the first of these procedures often occurs at birth," Everett said. (
  • These are very sick children, and we have done a brilliant job of improving overall survival from congenital heart surgery, but we have far to go to improve the long-term outcomes of our patients. (
  • He said that recent studies found that after heart surgery, about 40 per cent of infant patients will have brain abnormalities that show up in MRI scans. (
  • Methods A sample of patients with a nonhaemorrhagic injury from the Trauma Audit and Research Network (TARN) was compared with a healthy, non-injury sample from the Health Survey for England (HSE) databases. (
  • The FDA did, however, state that the increased incidence of heart problems experienced by patients taking the medication does not appear to be due to chance and that it would perform a deeper investigation. (
  • Researchers observed that patients with blockages in major arteries feeding the heart often have confoundingly different outcomes. (
  • The difference may be that this second group of patients has collateral arteries , tiny arteries that bypass blockages in hearts' major arteries and feed areas of the heart starved of oxygen. (
  • Such collateral arteries could help people with atherosclerosis or people recovering from a heart attack, except that collateral arteries are only seen in a minority of patients. (
  • The FDA recently issued a serious warning to hospitals, physicians and patients who have used or been implanted with Medtronic's heart devices, stating that certain parts of the instruments are causing inordinate numbers of injury and death throughout the country. (
  • The global recall was categorized as a Class I by the FDA, which is its most serious recall, meaning the product could reasonable cause catastrophic injury or death in patients. (
  • Clark, Perdue & List is actively investigating cases involving patients suffering from kidney damage as a result of using popular heart burn medications, including Nexium, Prilosec, and Prevacid, have been linked to kidney damage. (
  • Published online by the journal Developmental Biology , the study suggests that cardiac regeneration strategies should be based on the type and severity of heart injury. (
  • Activation of peripheral nociception also induces cardioprotection against IR injury via neurogenic pathway. (
  • The aim of the present study was to investigate the role of ERS in CTRP9 induced cardioprotection against IR injury in HFD induced type 2 diabetic heart and the underlying mechanism. (
  • Macrophages of the innate immune system play an important role in coordinating the intricate dance of cell populations that takes place during regeneration from injury. (
  • Stem cells have been implicated in the regeneration of skeletal muscle after traumatic and blast injuries, and have been shown to hone to muscle damaged after exercise. (
  • Notch 1 signaling is an endogenous method of protecting the heart from oxidative stress that can prevent cell suicide -- which is in direct conflict with the tagging for death work of FBXW7 -- so here FBXW7 modifies active Notch 1 so it can't function. (
  • Given to the central role of ROS in I/R injury, alleviating the oxidative stress is considered to be a potential option in limiting I/R-induced myocardial injury. (
  • In what way are spinal cord injuries similar to heart injuries? (
  • A new study by researchers at Children's Hospital Los Angeles has shown that neonatal mouse hearts have varying regenerative capacities depending upon the severity of injury. (
  • They found that CXCL12 was mostly restricted to arterial endothelial cells in uninjured neonatal mouse hearts. (
  • Brain injury is a problem which has long troubled those involved with perioperative care of the cardiac surgical patient. (
  • It is intended both to present the perspective of a surgeon interested in this problem, and to serve as an introduction to the overall issue of avoiding brain injury during heart surgery. (
  • Older migraine sufferers may be more likely to have silent brain injury. (
  • In newborns undergoing cardiac surgery, diagnosing early brain injury is important for timely intervention. (
  • Contrary to commonly held beliefs that further rehabilitation or recovery is impossible for such a population, one key premise of this study is that given appropriate training, people with chronic brain injury can continue to make substantial improvements in their functioning. (
  • Because this study provides empirical evidence that the brain and emotions are connected in the body - as opposed to operating in the separate domains created by the traditional mind/body divide - it also presents the possibility that this connection could be used to train individuals with brain injury to better self-regulate their behavior and thereby control disinhibition and impulsivity. (
  • Traumatic brain injury, or TBI, became a bigger concern for the military in recent years as more and more troops in the Iraq and Afghanistan wars began suffering from head injuries from bombings and other explosions. (
  • SCN will support a total of 24 goal-directed projects from across Canada that are moving research from lab bench to bedside in areas such as brain injury, muscular dystrophy and vision repair. (
  • Because it is often difficult to evaluate sedated, mechanically-ventilated infants for brain injury, we set out to determine whether using a blood test would be a more efficient and accurate method of evaluating newborns undergoing cardiac surgery. (
  • Acute myocardial infarction, commonly known as a heart attack, can be classified according to the extent of damage to the heart muscle. (
  • 5 However, the most commonly used enzymes, including creatine kinase (CK) and its myocardial fraction CK myocardial band (MB), aspartate aminotransferase, and lactate dehydrogenase, are limited in their ability to detect myocardial injury by short diagnostic windows, limited sensitivities, and lack of specificity because of their presence in skeletal muscle. (
  • Donated hearts are most commonly subjected to static cold storage, which deprives the tissues of necessary oxygen, nutrients, and electromechanical stimulation, thus providing a limited time window before heart function wanes and the organs become unusable. (
  • Hsps commonly played an important role in the protection of the heart after cold stress. (
  • More than 4,000 devices, commonly used during open heart surgery, were recalled after dozens of injuries and one death. (
  • New research reveals that morphological changes in response to cardiac injury occur rapidly, with implications for the development of therapeutic strategies. (
  • Studies that enable the underlying mechanisms of heart function to be examined after spinal cord injury are simply not possible in humans but by closely mimicking the injuries that occur in humans the findings are more readily able to be transferred to humans. (
  • In children, most finger, hand, or wrist injuries occur during sports or play or from accidental falls. (
  • Brandenburger T, Grievink H, Heinen N, Barthel F, Huhn R, Stachuletz F, Kohns M, Pannen B, Bauer I (2014) Effects of remote ischemic preconditioning and myocardial ischemia on microRNA-1 expression in the rat heart in vivo. (
  • However, unlike APN, CTRP9 protects diabetic heart against IR injury [14], but with partially understood mechanisms. (
  • the activity of superoxide dismutase and glutathione peroxidase in the heart first increased and then decreased. (
  • People fearful of hospitals may decide to "tough it out" if they develop the warning signs that can precede cardiac arrest, like shortness of breath, dizziness and heart palpitations. (
  • Studies using animal models of diabetes have demonstrated that the metabolic alterations occurring at the myocyte level may contribute to the severity of ischemic injury in diabetic hearts. (
  • Deviant metabolic regulation due to increased flux through aldose reductase in diabetic hearts may influence the ability of the myocardium to withstand ischemia insult. (
  • Zopolrestat reduced sorbitol levels before ischemia in diabetic hearts. (
  • Creatine kinase release was reduced by ∼50% in both nondiabetic and diabetic hearts treated with zopolrestat. (
  • Studies have revealed that APN protects against myocardial IR injury, while the cardioprotective effect is attenuated in diabetic condition [4-6]. (
  • however, whether ERS was involved in CTRP9 induced cardioprotection in diabetic heart has never been investigated. (
  • DEX pretreatment protects heart against myocardial I/R injury in diabetic rat. (
  • DEX pretreatment reduces myocardial I/R injury of diabetic rat via activating PI3K/Akt signaling. (
  • If you or a loved one suffered a heart attack or other cardiac injury as the result of a diabetic therapy, contact us today for a confidential and free case evaluation. (
  • Although further studies are necessary, these data also suggest that IL-1β might function as a sensor of myocyte amylin uptake and a potential mediator of myocyte injury. (
  • Doctors are also seeing injuries to the heart -- from heart attack, to inflammation of the heart muscle, to potentially fatal heart arrhythmias. (
  • Another heart complication seen in COVID-19 is myocarditis, an inflammation of the heart muscle. (
  • That could mean the athletes had myocarditis, an inflammation of the heart muscle most frequently caused by viral infections. (
  • The harmful impact of acute injuries on heart health was similar to that of diabetes , the researchers said. (
  • Amylin deposition in the pancreas and in extrapancreatic tissues, including the heart, was mirrored in a rat model of type 2 diabetes expressing human amylin in the pancreas (HIP) ( 6 , 7 , 11 - 16 ). (
  • Actos & Drug Injuries In 2011, the FDA issued a warning regarding a certain drug which is used by many Americans to manage type 2 diabetes. (
  • Funded trials will focus on evaluating a stem cell therapy for diabetes, using expanded stem cells from cord blood in the treatment of multiple myeloma and assessing an enhanced cell therapy for heart repair. (
  • He has over 10 years of experience in putting physiological knowledge into play to help coaches make better coaching decisions in player development, performance optimization and injury prevention. (
  • Based on these results, the researchers concluded that baicalein can effectively reduce liver injury induced by myocardial I/R by regulating cell death in the liver. (
  • The researchers concluded that baicalein can protect the liver from acetaminophen-induced liver damage and can be used to treat liver injuries. (
  • Spinal cord injury affects the heart, that's what research published in Experimental Physiology and carried out by researchers from University of British Columbia, Canada has found. (
  • This rodent model was used because it allowed the researchers to carefully control the amount of damage to the spinal cord during the injury and definitively assess heart function as well as examine how the cells in the heart change. (
  • The cause is unclear, with some researchers speculating the coronavirus may sometimes directly infect the heart. (
  • The images indicated swelling in the heart muscle and possible injury to cells in four of the athletes, or 15 percent, researchers report online September 11 in JAMA Cardiology. (
  • Researchers have found that instead of a single type of macrophage, there are at least four types that live within the uninjured heart, and that number increases to 11 after a heart attack, which indicates the immune system behaves in much more complex fashion than was imagined. (
  • Researchers also found large numbers of macrophages are attracted to the heart after a heart attack, and a small number enter into the neonatal state, except, too late. (
  • The plaintiff in the Juul injury lawsuit alleges that Juul manufactures and markets products that are inherently defective and do not perform safely as per user expectations, expectations created by Juul's pervasive marketing. (
  • When the hospital staff doesn't take the required measures to prevent injury to the child or mother when it is clear that the baby is in distress, the resulting birth injuries could be considered medical malpractice and the family may be able to file a lawsuit for the cost of care associated with the resulting injuries or conditions as well as any pain and suffering caused. (
  • At least one infected patient has filed an injury lawsuit against the company, Olympus American, for failing to instruct hospitals on proper disinfection techniques. (
  • A California court of appeals recently reversed a previous decision that prevented a Medtronic bone fuse injury lawsuit from going forward. (
  • In addition, the severity of intestinal and pulmonary injury was assessed with different scoring methods, respectively. (
  • In the early treatment model PD123319 attenuated cardiopulmonary injury by reducing alveolar septal thickness, pulmonary influx of inflammatory cells, including macrophages and neutrophils, medial wall thickness of small arterioles, and extravascular collagen III deposition, and by preventing RVH. (