Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
The hollow, muscular organ that maintains the circulation of the blood.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)
A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).
Pathological conditions involving the HEART including its structural and functional abnormalities.
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
The transference of a heart from one human or animal to another.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
A slowly progressive condition of unknown etiology, characterized by deposition of fibrous tissue in the retroperitoneal space compressing the ureters, great vessels, bile duct, and other structures. When associated with abdominal aortic aneurysm, it may be called chronic periaortitis or inflammatory perianeurysmal fibrosis.
The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.
The chambers of the heart, to which the BLOOD returns from the circulation.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Elements of limited time intervals, contributing to particular results or situations.
Examinations used to diagnose and treat heart conditions.
A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).
Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Contractile activity of the MYOCARDIUM.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Perisinusoidal cells of the liver, located in the space of Disse between HEPATOCYTES and sinusoidal endothelial cells.
Spindle-shaped cells with characteristic CONTRACTILE PROTEINS and structures that contribute to the WOUND HEALING process. They occur in GRANULATION TISSUE and also in pathological processes such as FIBROSIS.
Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Infections with bacteria of the genus PSEUDOMONAS.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Disorder characterized by a wide range of structural changes in PERITONEUM, resulting from fibrogenic or inflammatory processes. Peritoneal fibrosis is a common complication in patients receiving PERITONEAL DIALYSIS and contributes to its gradual decrease in efficiency.
Endomyocardial fibrosis. Problems in differential diagnosis. Heart. 1976 Apr 1;38(4):369-74. "Ayodele Olajide Falaise's ... and dilated cardiomyopathy Hypertension Heart failure Ischaemic Heart disease Congenital heart diseases The human heart ... JACC: Heart Failure. 2014 Jun 1;2(3):250-9. Falase AO, Ayeni O, Sekoni GA, Odia OJ. Heart failure in Nigerian hypertensives. ... Contemporary profile of acute heart failure in Southern Nigeria: data from the Abeokuta Heart Failure Clinical Registry. ...
therefore they are not characteristic of rheumatic heart disease Stage 3. Late fibrosis stage. It is the stage of healing by ... They result from inflammation in the heart muscle and are characteristic of rheumatic heart disease. These nodules were ... Evolution of Aschoff nodules typically involve 3 stages of development all of which may be present in the heart at the same ... Aschoff bodies are found in all the three layers of the heart, least chance in the pericardium. The cardiac manifestations of ...
"Cystic Fibrosis Center". pediatrics.northwell.edu. Archived from the original on 2020-09-26. Retrieved 2020-04-05. "CHD Clinic ... Boyle, Chris (27 October 2017). "Long Island McDonald's Gives a Heart - and $95,263 - to Help Support the Long Island Ronald ... Adult Congenital Heart Program". ACHA. Archived from the original on 2020-09-26. Retrieved 2020-04-10. "Trauma Centers". ...
... it is said to be usable by men suffering from diabetes or heart problems and those who have undergone a prostatectomy.[10] It ... In babies with congenital heart defects, it is used by slow injection into a vein to open the ductus arteriosus until surgery ... hypoplastic left heart syndrome, pulmonary atresia/stenosis, tricuspid atresia/stenosis, transposition of the great arteries) ... useful when the threat of premature closure of the ductus arteriosus exists in an infant with ductal-dependent congenital heart ...
The first are rare genetic variants that have a severe effect predominantly on simple traits (e.g. Cystic fibrosis, Huntington ... Heart Disease). Between these two types of genetic variants lies a significant gap of knowledge, which the 1000 Genomes Project ...
In 1988, Bentley was diagnosed with cystic fibrosis. Despite this, she has won 11 Ironman competitions. In 2006, Bentley placed ... CS1 maint: discouraged parameter (link) Krabel, Herbert (11 January 2008). "Lisa Bentley - big heart, big smile". Slowtwitch. ... "Famous People with Cystic Fibrosis". Life123, Inc. Archived from the original on 7 September 2012. Retrieved 25 June 2010. ...
Short-term physiological effects include increases in blood pressure and heart rate. The increased blood pressure and heart ... In 2014 a 72-year-old male with pulmonary fibrosis was hospitalized for 5 days at the Maisonneuve-Rosemont Hospital in Montreal ... which increases both the risk of long-term heart disease and an acute event such as a myocardial infarction (heart attack). ... Daily e-cigarette use is correlated with an increased risk of a heart attack (myocardial infarction) in health surveys. There ...
2013). "Fibrosis in heart failure subtypes". Eur Rev Med Pharmacol Sci. 17 (17): 2302-9. PMID 24065222. Kamata, S.; et al. ( ... IR significantly contributes to tissue fibrosis. "Ischemia": an inadequate blood supply to an organ or part of the body.[ ... systematic review and meta-analysis of large animal models of ischaemic heart disease". Cardiovasc Res. 91 (4): 649-58. doi: ... While some investigations suggest a possible beneficial effect of mesenchymal stem cells on heart and kidney reperfusion injury ...
"Roche to Acquire Fibrosis-Focused Promedior for up to $1.4 Billion". "Promedior Enters into Definitive Merger Agreement to be ... Activase (alteplase), for heart attacks. Akynzeo (netupitant/palonosetron), for nausea and vomiting, licensed by Eisai Co. and ... In November Roche acquired Promedior and its lead treatment - PRM-151 - for the treatment of idiopathic pulmonary fibrosis, for ... TNKase (tenecteplase), for heart attacks. Toradol (ketorolac), for pain management. Valcyte (valganciclovir), for ...
... heart disease. Warren Adler, 91, American author (The War of the Roses, Random Hearts), liver cancer. Gustavo Arias Murueta, 95 ... Dina, 62, Portuguese singer, pulmonary fibrosis. Al Hester, 86, American author and academic. Jorge Menéndez, 67, Uruguayan ... But it all turned out pretty great in the end' Dutch cyclist Robert de Greef dies aged 27, three weeks after suffering heart ... Paul Raymond, 73, English keyboardist and guitarist (Plastic Penny, UFO, Savoy Brown), heart attack. J. K. Rithesh, 46, Indian ...
... heart attack. (b. 1960). January 18 Lola Landa, 94, activist and writer; heart attack. (b. 1926). Francisco Daniel Rivera ... Cándido Pérez" (in Spanish) Fallece el director José Ángel García, padre de Gael García, de fibrosis (in Spanish) "Matan al ... Cándido Pérez). January 22 José Ángel García, 69-70, actor and television director (La rosa de Guadalupe); pulmonary fibrosis. ... April 21 Blanca Alfaro Vázquez, politician ( MRN), candidate for federal deputy; heart attack. Enrique Becker, actor (Mundo de ...
The heart remained in alcohol, and the container was not opened, so it could not be touched or sampled. Closer inspection ... Majka, L; Goździk, J; Witt, M (2003). "Cystic fibrosis--a probable cause of Frédéric Chopin's suffering and death". Journal of ... Attempts were made to gain permission to extract a small amount of tissue from Chopin's heart in order to test it for a range ... "Chopin's Heart - The Quest to Identify the Mysterious Illness of the World's Most Beloved Composer." Lagerberg, 2011, ISBN 1- ...
Shillingford, J. P.; Somers, K. (1961). "Clinical and Hæmodynamic Patterns in Endomyocardial Fibrosis". British Heart Journal. ... His major contributions were in the study and care of patients in the acute stages of heart attack, at a time when little was ... Measurement in the intensive care of heart disease". Proceedings of the Royal Society of Medicine. 58 (10): 773-775. doi: ... He published over 400 articles that form the basis of much of our current understanding of heart disease. ...
Kaleem Omar, 72, Pakistani poet and journalist, heart failure. Sky Saxon, 71, American rock musician (The Seeds), heart failure ... Peter Arundell, 75, British racing driver, pulmonary fibrosis. Douglas Bunn, 81, British barrister and horse breeder, founder ... Dirk du Toit, 65, South African politician, suspected heart failure. Notable people have been killed in Air France Flight 447: ... James F. Calvert, 88, American naval officer, 46th Superintendent of the U.S. Naval Academy, heart failure. David Carradine, 72 ...
Adrian Kantrowitz, 90, American physician, performed the first pediatric heart transplant, heart failure. Tsvetanka Khristova, ... Robert Zarinsky, 68, American serial killer, pulmonary fibrosis. Bill Drake, 71, American radio programmer. Ulises Dumont, 71, ... George C. Chesbro, 68, American novelist, heart failure. Paul H. Todd, Jr., 87, American politician, member of the House of ... David de Caires, 70, Guyanese journalist and editor, founder of Stabroek News, complications from heart attack. Oscar Lathlin, ...
Later in the year, a 15-month-old patient became the youngest person in New England to receive a heart transplant. Boston ... "Adult Cystic Fibrosis Program - Brigham and Women's Hospital". www.brighamandwomens.org. Retrieved 2020-12-17. "Maternal Fetal ... Felix Engel and Mark Keating get adult heart-muscle cells to divide and multiply in mammals, the first step in regenerating ... BCH has one of the largest adult congenital heart disease (ACHD) programs in the U.S., providing congenital cardiac care to ...
Individuals with cystic fibrosis often develop nasal polyps.[citation needed] Amiodarone is a drug used in the treatment of ... arrhythmias of the heart. A clinical study demonstrated that the use of this drug induced anosmia in some patients. Although ...
Congenital heart disease 10. Hepatic fibrosis There is no cure to LNMS. However, symptomatic treatment is often provided. The ...
A last resort form of treatment is heart transplant. An infant with dilated, failing heart was no rarity on the pediatric wards ... It should not be confused with endomyocardial fibrosis. EFE is characterized by a thickening of the innermost lining of the ... idiopathic hypertrophy of the heart, endocardial sclerosis, cardiac enlargement of unknown cause, etc. Some of these hearts ... This was thought to be a disease affecting both the heart muscle and the endocardium and it was given various names such as: ...
Health, St Vincent's Heart. "Home." St Vincent's Lung Health, St Vincent's Heart Health, www.svhlunghealth.com.au/conditions/ ... Prolonged ILD may result in pulmonary fibrosis, but this is not always the case. Idiopathic pulmonary fibrosis is interstitial ... Lower lung predominance Idiopathic pulmonary fibrosis, pulmonary fibrosis associated with connective tissue diseases, ... basal and pleural-based fibrosis with honeycombing) and pathologic (temporally and spatially heterogeneous fibrosis, ...
Over-absorption of iron; accumulation of iron in vital organs (heart, liver, pancreas); organ damage; heart disease; cancer; ... Cystic fibrosis. Large amount of abnormally thick mucus in the lungs and intestines; leads to congestioni, pneumonia, diarrhea ... Over-absorption of iron; accumulation of iron in vital organs (heart, liver, pancreas); organ damage; heart disease; cancer; ... There is a variety of DTC tests, ranging from tests for breast cancer alleles to mutations linked to cystic fibrosis. Benefits ...
This is a frequent occurrence with pleural effusion, caused by congestive heart failure (CHF). Leakage of air into the pleural ... In atelectasis manifestations that result from the mucus plugging of the airways as seen in patients with cystic fibrosis and ... William Pasteur, pioneer pulmonologist Orenstein, David M. (2004). Cystic Fibrosis: A Guide for Patient and Family. Lippincott ... Causes include granulomatous disease, necrotising pneumonia and radiation fibrosis. Chronic atelectasis may take one of two ...
Patrice L'Heureux, 46, Canadian boxer, heart attack. Nino Lombardo, 91, Italian politician, Deputy (1976-1994), heart failure. ... Bob Jones, 91, American cartoonist and illustrator, pulmonary fibrosis. Thampi Kannanthanam, 64, Indian film director ( ... Takumi Furukawa, 101, Japanese film director (Season of the Sun, Cruel Gun Story), heart failure. José Lluis, 80, Spanish ... Oleg Pavlov, 48, Russian writer, heart attack. Marie M. Runyon, 103, American political activist and politician, member of the ...
Kannan, Ramya; Kumar, S.R. Ashok (September 8, 2010). "Tamil actor Murali dies of heart attack". The Hindu. Archived from the ... Barbara B. Smith, 88, American religious leader, pulmonary fibrosis. Gus Williams, 73, Australian Aboriginal leader and country ... James Bacon, 96, American author, journalist and actor (Escape from the Planet of the Apes, Meteor), heart failure. Øystein ... Eileen Nearne, 89, British Special Operations Executive agent in World War II, heart attack. (body discovered on this date) ...
June 14 - Clóvis Rossi [pt] 76, Brazilian journalist (Folha de S. Paulo), heart attack. June 17 - Moacyr Grechi, 83, Brazilian ... Paulo Pagni [pt], 61, Brazilian drummer (RPM), pulmonary fibrosis. June 28 - Mário Jorge da Fonseca Hermes, 92, Brazilian ... June 8 - Andre Matos, 47, Brazilian singer (Viper, Angra, Shaman), heart attack. June 9 - Rafael Miguel, 22, Brazilian actor ( ... Luisinho Lemos, 67, Brazilian footballer, heart attack. June 3 Sônia Guedes [pt], 86, Brazilian actress. Paulo Zimbres [pt], 86 ...
Liam Mchugh - for services to the Cystic Fibrosis Trust. Samuel Mcilwrath - for services to the community in Comber, Northern ... Helen Clare Meehan - lately Specialist Palliative Care Nurse, Heart of England NHS Foundation Trust. For services to Palliative ... Jane Tomkinson, Chief Executive, Liverpool Heart and Chest Hospital NHS Foundation Trust. For services to NHS Financial ...
A Mother's Heart), heart failure. Timothy A. Cohn, 59, American hydrologist, mantle cell lymphoma. Mildred Dresselhaus, 86, ... John M. Hayes, 76, American geochemist, pulmonary fibrosis. Roy Heenan, 81, Canadian lawyer and academic, founder of Heenan ... heart ailment. Evangelos Basiakos, 63, Greek politician, MP (since 1989), heart attack. Nicole Bass, 52, American bodybuilder ... Fame and Glory, 11, Irish racehorse, winner of the Irish Derby and Ascot Gold Cup, heart attack. Paulo Henrique Filho, 52, ...
Lin Ching-hsuan, 65, Taiwanese writer, heart attack. Jim McKean, 73, Canadian baseball umpire, heart attack. Jonas Mekas, 96, ... pulmonary fibrosis. Otto Schubiger, 94, Swiss ice hockey player (national team), Olympic bronze medalist (1948). Ishtvan Sekech ... Louis Rams), heart attack. Gebhardt von Moltke, 80, German diplomat, Ambassador to the UK (1997-1999). Derek Piggott, 96, ... Pepe Smith, 71, Filipino rock musician (Juan de la Cruz Band, Speed, Glue & Shinki, Asin), heart failure. John Raymond Smythies ...
"Danny Paton". Heart of Midlothian FC. March 11, 2011. Archived from the original on September 16, 2012. Retrieved July 15, 2019 ... Sara Ruddick, 76, American philosopher and author, pulmonary fibrosis. Dorothy Young, 103, American actress, assistant to Harry ... Leonard Lomell, 91, American World War II veteran, recipient of the Silver Star and Purple Heart, natural causes. John M. ... "Famous comedian Liaqat Soldier dies of a heart attack". SAMAA TV. April 1, 2011. Archived from the original on August 26, 2011 ...
Gourdie RG, Dimmeler S, Kohl P (September 2016). "Novel therapeutic strategies targeting fibroblasts and fibrosis in heart ... kidney fibrosis, retroperitoneal fibrosis) that this mechanism fails to work, leading to persistence of the myofibroblasts, and ... In many organs like liver, lung, and kidney they are primarily involved in fibrosis. In the wound tissue they are implicated in ... Myofibroblasts may interfere with the propagation of electrical signals controlling heart rhythm, leading to arrhythmia in both ...
May 2008). "Estimation of the radiation dose from CT in cystic fibrosis". Chest. 133 (5): 1289-91, author6 reply 1290-1. doi: ... PET is also an important research tool to map normal human brain and heart function, and support drug development. ...
In addition to inflammation, chronic graft-versus-host disease may lead to the development of fibrosis, or scar tissue, similar ... including the heart, liver, and muscle, and these cells had been suggested to have the abilities of regenerating injured tissue ...
The physical examination typically includes an assessment of volume state, blood pressure, heart, lungs, peripheral arteries, ...
Wu J, Zern MA (2000). "Hepatic stellate cells: a target for the treatment of liver fibrosis". Journal of Gastroenterology. 35 ( ... Heart valve calcification[3]. *Hypercalcemia. *Increased intracranial pressure manifesting as cerebral edema, papilledema, and ... If liver damage has progressed into fibrosis, synthesizing capacity is compromised and supplementation can replenish PC. ... "Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption". Liver International. 26 (2): ...
This test will pick up diffusion impairments, for instance in pulmonary fibrosis.[19] This must be corrected for anemia (a low ... Heart-lung transplant. Chest wall, pleura,. mediastinum,. and diaphragm. pleura/pleural cavity. Thoracentesis. Pleurodesis. ... Spirometry is helpful in assessing breathing patterns that identify conditions such as asthma, pulmonary fibrosis, cystic ... such as pulmonary fibrosis) the FEV1 and FVC are both reduced proportionally and the value may be normal or even increased as a ...
fibrosis). External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. ... Advanced COPD leads to high pressure on the lung arteries, which strains the right ventricle of the heart.[5][37][38] This ... "U.S. National Heart Lung and Blood Institute. Archived from the original on 2012-04-27. Retrieved 2013-07-23.. ... "National Heart, Lung, and Blood Institute. July 31, 2013. Archived from the original on November 18, 2013. Retrieved November ...
The resulting inadequate blood flow produces tubular atrophy, interstitial fibrosis, and glomerular alterations (smaller ... Hypertensive heart disease. *Hypertensive emergency. *Hypertensive nephropathy. *Essential hypertension. *Secondary ... Light micrograph showing signs of hypertensive nephropathy: interstitial fibrosis, tubular atrophy with thickened tubular ... periglomerular fibrosis). In advanced stages, kidney failure will occur. Functional nephrons[5] have dilated tubules, often ...
... heart defects, cystic fibrosis, depression, seizure disorders, Sickle Cell disease, kidney failure, and liver failure.[13] ... "National Heart, Lung, and Blood Institute. October 1, 2010. Retrieved January 15, 2014.. ... Müller FM, Seidler M (August 2010). "Characteristics of pathogenic fungi and antifungal therapy in cystic fibrosis". Expert Rev ...
Remillard CV, Yuan JX (May 2005). "PGE2 and PAR-1 in pulmonary fibrosis: a case of biting the hand that feeds you?". American ... for use as anti-clotting agents for the treatment of heart disease. SCH-530,348 SCH530348 has been recently shown to attenuate ... in pulmonary fibrosis". Biochemical Society Transactions. 30 (2): 211-6. doi:10.1042/BST0300211. PMID 12023853. Tellez C, Bar- ...
... myocardial fibrosis, valvular heart disease, coronary artery disease, heart arrhythmia and peripheral artery disease. Radiation ... Fibrosis. Tissues which have been irradiated tend to become less elastic over time due to a diffuse scarring process.. ... Radiation can increase the risk of heart disease and death as observed in previous breast cancer RT regimens.[18] Therapeutic ... Deep inspiration breath-hold (DIBH) is a method of delivering radiotherapy while limiting radiation exposure to the heart and ...
... including the heart itself. The increased heart rate also leads to increased work and oxygen demand by the heart, which can ... Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.[1] In general, a resting heart ... When the heart beats excessively or rapidly, the heart pumps less efficiently and provides less blood flow to the rest of the ... Heart rate is considered in the context of the prevailing clinical picture. For example, in sepsis ,90 bpm is considered ...
Michael Angelis, 68, English actor (Boys from the Blackstuff, The Liver Birds, Thomas & Friends), heart attack.[327] ... Idir, 70, Algerian folk singer-songwriter ("A Vava Inouva") and guitarist, pulmonary fibrosis.[18] ... Larry Kramer, 84, American playwright (The Normal Heart, The Destiny of Me), novelist (Faggots) and LGBTQ+ rights activist, ... Lennie Niehaus, 90, American saxophonist and movie composer (Unforgiven, The Bridges of Madison County, Space Cowboys), heart ...
They are associated with central nervous system involvement, kidney disease, lung fibrosis and pericarditis in SLE, but they ... anti-Ro antibodies can cross the placenta and cause heart block[20][21] and neonatal lupus in babies.[22] In Sjögren's syndrome ... "The prevention, screening and treatment of congenital heart block from neonatal lupus: a survey of provider practices" ...
For example, during sarcopenia, there is a replacement of muscle fibres with fat and an increase in fibrosis. ... "Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older women". J Am Geriatr ... "Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate ...
Aggressive Berger's disease (a rarer form of the disease) can attack other major organs, such as the liver, skin and heart. ... heart failure, reactive arthritis, ankylosing spondylitis and HIV. Diagnosis of Berger's disease and a search for any ...
This elevation may be caused by congenital heart disease, cor pulmonale, pulmonary fibrosis, too much erythropoietin, or ... Heart of Steel (Hemoglobin) (2005) by Julian Voss-Andreae. The images show the 5-foot (1.60 m) tall sculpture right after ... Artist Julian Voss-Andreae created a sculpture called "Heart of Steel (Hemoglobin)" in 2005, based on the protein's backbone. ... Am Heart J. 151 (1): 91.e1-91.e6. doi:10.1016/j.ahj.2005.10.008. PMID 16368297.. ...
"Hepatocyte growth factor is a strong predictor of mortality in patients with advanced heart failure". Heart. 97 (14): 1158-63. ... derived stem cell therapy ameliorates ionizing irradiation fibrosis (RIF) via hepatocyte growth factor mediated TGF‐β down ... Plasma from patients with advanced heart failure presents increased levels of HGF, which correlates with a negative prognosis ... and CCR4 which in turn imbues them with the ability to migrate into heart tissue.[11] HGF also promotes angiogenesis in ...
Micrograph of a heart with fibrosis (yellow) and amyloidosis (brown). Movat's stain. ...
... and congestive heart failure. Any inflammatory state that affects the heart can cause fibrosis of the atria. This is typically ... A Holter monitor is a wearable ambulatory heart monitor that continuously monitors the heart rate and heart rhythm for a short ... congenital heart disease, and previous heart surgery.[24] Congenital heart disease is a strong risk factor for developing ... Other heart-related risk factors include heart failure, coronary artery disease, cardiomyopathy, and congenital heart disease.[ ...
... easing work load on the heart. Oxygen therapy is used to treat emphysema, pneumonia, some heart disorders (congestive heart ... 2 partial pressure more than 60 kPa can eventually lead to permanent pulmonary fibrosis.[123] Exposure to a O. 2 partial ...
Heart failure and cirrhosis are also a common cause of distension. In both of these disorders, fluid accumulates in the abdomen ...
2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). World Health Organization Classification ... People with severe pulmonary fibrosis and severe emphysema with a life expectancy ,1 year should be considered poor candidates ...
... easing work load on the heart. Oxygen therapy is used to treat emphysema, pneumonia, some heart disorders (congestive heart ... 2 partial pressure more than 60 kPa can eventually lead to permanent pulmonary fibrosis.[123] Exposure to a O. 2 partial ...
Hypertonic saline is currently recommended by the Cystic Fibrosis Foundation as a primary part of a cystic fibrosis treatment ... The amount of normal saline infused depends largely on the needs of the person (e.g. ongoing diarrhea or heart failure). ... Reeves EP et al (2011). "Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis." Am J Respir ... when he determined the optimal salt concentrations to maintain the contractility of frog heart muscle tissue. Normal saline is ...
... which leads to resorption and replacement of bone with angiomas and/or fibrosis. Current treatments are experimental only. The ... heart & lung): Pleurodesis Ligation of thoracic duct Pleurperitoneal shunt Radiation therapy Pleurectomy Surgical resection ...
Cardiotoxicity (heart damage) is especially prominent with the use of anthracycline drugs (doxorubicin, epirubicin, idarubicin ... and liver fibrosis.[104][105] ...
fibrosis). External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. ... National Heart Lung and Blood Institute (2009). "Who Is at Risk for Bronchitis?". National Institutes of Health. Archived from ... Mosby (Elsevier). Chapter 33: Bronchitis, Bronchiectasis, and Cystic Fibrosis. ISBN 978-0323025737.. ...
Fibrosis around the brachial or lumbosacral plexus Radiotherapy may produce excessive growth of the fibrous tissue (fibrosis) ... Superior vena cava syndrome The superior vena cava (a large vein carrying circulating, de-oxygenated blood into the heart) may ... fibrosis, myelopathy, bone necrosis, neuropathy or plexopathy; chemotherapy, often associated with mucositis, joint pain, ...
This causes the fibrosis of the arterial wall, with reduction of number of smooth muscle cells, abnormal collagen synthesis, ... American Heart Association Journal. 44: 3613-3622. doi:10.1161/STROKEAHA.113.002390.. ,access-date=. requires ,url=. (help) ...
Find beautiful designs on our great selection of high quality printed Heart Charm Necklaces. ✓Free Returns ✓High Quality ... Shop Cystic Fibrosis Heart Charm Necklaces from CafePress. ... Cystic-Fibrosis-Cross--Heart- Necklace Heart Charm $19.95. $ ...
Cystic Fibrosis Pathogenesis and treatment of cystic fibrosis; cystic fibrosis transmembrane conductance regulator (CFTR) ...
2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
PURPOSE OF REVIEW: The clinical importance of fibrosis in hypertensive heart disease is now well recognized. However, the ... SUMMARY: Myocardial fibrosis in hypertensive heart disease remains an area of intensive research. Whereas recent work has ... PURPOSE OF REVIEW: The clinical importance of fibrosis in hypertensive heart disease is now well recognized. However, the ... It also summarizes the most recent data examining the genetic aspects of myocardial fibrosis and further clarifies potential ...
Idiopathic Pulmonary Fibrosis. What Is Idiopathic Pulmonary Fibrosis?. Idiopathic pulmonary fibrosis (IPF) is a serious ... What causes idiopathic pulmonary fibrosis?. The exact cause of idiopathic pulmonary fibrosis is not known. It was believed that ... What are the symptoms of idiopathic pulmonary fibrosis?. Symptoms of idiopathic pulmonary fibrosis tend to develop slowly and ... Treatment for idiopathic pulmonary fibrosis. There is currently no cure for idiopathic pulmonary fibrosis, however, treatments ...
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Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative ... download and read Interstitial Fibrosis in Heart Failure ebook online in PDF format for iPhone, iPad, Android, Computer and ... Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative ... Architecture of the Normal and Remodeled Heart.- The Architecture of the Heart: Myocyte Organization and the Cardiac ...
... has been found to reverse established cardiac fibrosis in heart failure models, according to a study led by Roger J. Hajjar, MD ... Study shows cardiac fibrosis reversal through gene targeting in heart failure models. The Mount Sinai Hospital / Mount Sinai ... "Our research is the first to demonstrate the ability to reverse cardiac fibrosis in heart failure models by targeting a ... CCN5, a matricellular protein, has been found to reverse established cardiac fibrosis in heart failure models, according to a ...
... which underlies several heart diseases, could be prevented by inhibiting specific proteins that bind to RNA while its code is ... The formation of excess fibrous tissue in the heart, ... "Heart disease is a prominent cause of mortality, accounting for ... New cardiac fibrosis study identifies key proteins that translate into heart disease The formation of excess fibrous tissue in ... Cardiac fibrosis, a condition characterised by scarring in the heart, is caused by the activation of fibre-producing cells ...
Heart Information and Support*About your heart condition*How your heart works*Blood supply to your heart ... Coronavirus & Heart Conditions. If you have a heart condition and you are worried about coronavirus. Coronavirus and heart ... Chest Heart & Stroke Scotland 2021 Contact us. Chest Heart & Stroke Scotland Head Office. Third Floor, Rosebery House. 9 ... How we can help (heart)*Living with your heart condition*Control cholesterol ...
Sharing Flipping a Molecular Switch for Heart Fibrosis using Facebook. *Sharing Flipping a Molecular Switch for Heart Fibrosis ... Flipping a Molecular Switch for Heart Fibrosis A healthy heart is a pliable, ever-moving organ. But under stress-from injury, ... Now, researchers at Gladstone Institutes have discovered a master switch for fibrosis in the heart. When the heart is under ... "To treat a heart failure patient with a BET inhibitor is a sledgehammer approach, because we might prevent fibrosis, but wed ...
Husband of woman dying from cystic fibrosis pens heart-breaking letter pleading for more organ donors. Young mother Ashley ... When we met 10 years ago we both knew your cystic fibrosis would make things difficult, but we both vowed never to give in to ... Cystic fibrosis , which fills the lungs with a clogging mucus, can be the most devastating disease. ... Number of people with cystic fibrosis on the lung transplant waiting list who will die waiting for new lungs ...
The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has stopped one arm of a ... Part of the National Institutes of Health, the National Heart, Lung, and Blood Institute (NHLBI) plans, conducts, and supports ... The Institute also administers national health education campaigns on women and heart disease, healthy weight for children, and ... was designed and conducted by the Idiopathic Pulmonary Fibrosis Clinical Research Network, funded by the NHLBI. The PANTHER-IPF ...
Targeting the Cardiac Myofibroblast Secretome to Treat Myocardial Fibrosis in Heart Failure Karl T. Weber and Javier Díez ... Plasma and Cardiac Galectin-3 in Patients With Heart Failure Reflects Both Inflammation and FibrosisCLINICAL PERSPECTIVE ... 2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ... Microvascular Paradigm in Heart Failure With Preserved Ejection FractionA Quest for Proof of Concept Mark T. Waddingham and ...
A 40 year-old man from County Durham has become the first person in the world with cystic fibrosis to conquer the summit of ... Ed Owen, Chief Executive at the Cystic Fibrosis Trust said We offer Nick and his whole team many congratulations on this ... We are so proud of Nick, what he has achieved is a huge milestone in the history of cystic fibrosis and demonstrates his own ... A 40 year-old man from County Durham has become the first person in the world with cystic fibrosis to conquer the summit of ...
During AF in failing hearts, heterogeneous spatial distribution of fibrosis at the PLA governs AF dynamics and fractionation. ( ... 2007;101:839-847.) Key Words: heart failure atrial fibrillation fibrosis mapping numerical simulations ... and fibrosis, but how the distribution of fibrosis impacts AF dynamics has not been studied. HF was induced in sheep by ... hearts. PLA breakthroughs were the most frequent activation pattern in both groups (72.04.6 and 90.22.7%, HF and control, ...
Separating Cardiac Hypertrophy and Fibrosis. Over time, overloaded hearts typically become larger (a process called ... RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis ... RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis ... RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis ...
Fibrosis in heart and kidneys increases with smoking, according to research findings. In addition, smoking can worsen already ... Fibrosis in heart and kidneys increases with smoking: Study. Mohan Garikiparithi , Heart Health , December 7, 2016. * ... Home » Heart Health » Fibrosis in heart and kidneys increases with smoking: Study ... Fibrosis in heart and kidneys increases with smoking, according to research findings. In addition, smoking can worsen already ...
In order to be successful in preventing, attenuating or reversing cardiac fibrosis, it is essential to understand the processes ... They are activated by the disease-associated changes in mechanical properties of the heart, including stretch and increased ... remains an unresolved problem in most forms of heart disease. ... 1. Cardiac Fibrosis and Heart Disease. Cardiac fibrosis, the ... Cardiac fibrosis, the excessive accumulation of extracellular matrix (ECM), ...
Eur J Heart Fail. 2012 Jan;14(1):74-81. doi: 10.1093/eurjhf/hfr151. Epub 2011 Nov 16. Randomized Controlled Trial; Research ... Association of galectin-3 and fibrosis markers with long-term cardiovascular outcomes in patients with heart failure, left ... Eur J Heart Fail. 2012 Jan;14(1):74-81. doi: 10.1093/eurjhf/hfr151. Epub 2011 Nov 16. ... The extent to which the success of cardiac resynchronization therapy (CRT) is influenced by the degree of cardiac fibrosis and ...
Redondo Beach resident Claire Wineland, who captured nations hearts with struggle against cystic fibrosis, has died ... Stacey Armato, a councilmember in Hermosa Beach, whose 3-year-old son Massimo has cystic fibrosis and knew Wineland and her ... In the United States more than 30,000 people live with cystic fibrosis and more than 70,000 have the condition worldwide, ... Proceeds go toward families dealing with cystic fibrosis.. When Wineland learned she would receive a double lung transplant, ...
Cardiac fibrosis is a hallmark of cardiovascular remodeling associated with hypertension. The purpose of this study was to ... Fibrosis. Gene Expression. Guanylate Cyclase / metabolism*. Heart / physiopathology*. Immunohistochemistry. Male. Myocardium / ... These results suggest that sGC stimulator BAY 41-2272 might be effective to reduce fibrosis in hypertensive heart disease by ... Cardiac fibrosis is a hallmark of cardiovascular remodeling associated with hypertension. The purpose of this study was to ...
MRE is a highly sensitive tool that can evaluate liver fibrosis in children who undergo the Fontan procedure and enable earlier ... However, few reports have described its use in evaluating liver fibrosis in children with congenital heart disease (CHD). ... Non-invasive assessment of liver fibrosis by magnetic resonance elastography in patients with congenital heart disease ... MRE is a highly sensitive tool that can evaluate liver fibrosis in children who undergo the Fontan procedure and enable earlier ...
Abstract 1484: New Insights into the Kidney-Heart Connection: Mild Renal Insufficiency Induces Cardiac Fibrosis and Diastolic ... Abstract 1484: New Insights into the Kidney-Heart Connection: Mild Renal Insufficiency Induces Cardiac Fibrosis and Diastolic ... Abstract 1484: New Insights into the Kidney-Heart Connection: Mild Renal Insufficiency Induces Cardiac Fibrosis and Diastolic ... Abstract 1484: New Insights into the Kidney-Heart Connection: Mild Renal Insufficiency Induces Cardiac Fibrosis and Diastolic ...
Conrad CH, Brooks WW, Hayes JA, Sen S, Robinson KG, and Bing OH. Myocardial fibrosis and stiffness with hypertrophy and heart ... Moncrieff J, Lindsay MM, and Dunn FG. Hypertensive heart disease and fibrosis. Curr Opin Cardiol 19: 326-331, 2004. ... Heart-to-body weight and heart weight-to-tibia length ratios were increased from 3.61 ± 0.28 to 4.86 ± 0.27 mg/g (P , 0.05) and ... such as atherosclerosis and cardiac fibrosis. Fibrillin-1 being implicated in the pathogenesis of fibrosis of the liver and the ...
Heart Cystic Fibrosis Awareness Charms are sold in bulk at low wholesale prices for making your own awareness bracelets for ... These Cystic Fibrosis awareness heart charms are silver heart charms with a purple ribbon and the words "Cystic Fibrosis ...
Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis Zhi Zeng ... Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis. Clin ... apoptosis and fibrosis were evaluated in cultured neonatal rat cardiomyocytes and fibroblasts as well as in murine hearts. ... At the heart of tissue: endothelin system and end-organ damage Clin Sci (Lond) (August,2010) ...
... in patients meeting clinico-radiological profile for idiopathic pulmonary fibrosis (IPF) ... A tendency for ischaemic heart disease to precede IPF in the majority of cases suggests the possibility that broader systemic ... S134 High prevalence of ischaemic heart disease (IHD) in patients meeting clinico-radiological profile for idiopathic pulmonary ... S134 High prevalence of ischaemic heart disease (IHD) ...
Eur J Heart Fail. 2019 Mar;21(3):272-285. doi: 10.1002/ejhf.1406. Epub 2019 Feb 4. Research Support, Non-U.S. Govt ... The Netherlands Heart Institute, Nl-HI, Utrecht, The Netherlands.. Abstract. Fibrosis is a pivotal player in heart failure ... Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, ... Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of ...
  • Cardiac fibrosis, a condition characterised by scarring in the heart, is caused by the activation of fibre-producing cells called fibroblasts - which form one of the largest groups of cells in the heart - and underlies many heart diseases, including atrial fibrillation, dilated cardiomyopathy, and heart failure. (eurekalert.org)
  • This involves the transformation of fibroblasts into myofibroblasts, which leads to thickening and stiffening of the heart wall, making it less contractile and thus less able to pump blood around the body. (eurekalert.org)
  • When the heart is under stress, they found, the gene MEOX1 is turned on in cells called fibroblasts, spurring fibrosis. (trdrp.org)
  • While the scientists didn't find significant changes to heart muscle cells, they observed that the treatment induced striking changes in cardiac fibroblasts, which represent more than half the cells in the human heart. (trdrp.org)
  • The influences of H2R activation or inactivation on mitochondrial function, apoptosis and fibrosis were evaluated in cultured neonatal rat cardiomyocytes and fibroblasts as well as in murine hearts. (portlandpress.com)
  • The pathological remodeling process underlying ventricular dilation involves cardiomyocytes, which undergo eccentric hypertrophy, and also interstitial cells, including resident fibroblasts and macrophages (which are critically involved in tissue fibrosis). (biologists.org)
  • In mice, cardiac stress activates fibroblasts to express and secrete Loxl2 into the interstitium, triggering fibrosis, systolic and diastolic dysfunction of stressed hearts. (quanterix.com)
  • Fibroblasts are the predominant mediators of cardiac fibrosis, although the mechanistic insights and the therapeutic options are very limited [ 3 ]. (imedpub.com)
  • GRK2 inhibition in a clinically relevant mouse model, we also showed that inhibition reduced the activation of human heart failure cardiac fibroblasts. (medicaldialogues.in)
  • In fact, pergolide and cabergoline have high "affinity" for the 5-HT 2B serotonin receptors, which are expressed in heart valves and might mediate mitogenesis and, in turn, the proliferation of fibroblasts. (biomedcentral.com)
  • Further, we observed that STAT3 phosphorylation is limited to the proximal tubular epithelial cells during AKI, but in the case of fibrosis, STAT3 is expressed in other cell types including glomerular, interstitial cells and fibroblasts in murine and human kidneys. (americanheart.org)
  • BACKGROUND: Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) and depends on activation and differentiation of fibroblasts into myofibroblasts (MyoFb). (researchportal.be)
  • METHODS: Fibroblasts were isolated from the left ventricle of the explanted hearts of transplant recipients (ischemic and dilated cardiomyopathy), and from nonused donor hearts. (researchportal.be)
  • These cells include connective tissue cells, fibroblasts, which contribute to the development of heart failure by increasing the stiffness of the heart. (maastrichtuniversity.nl)
  • Idiopathic pulmonary fibrosis (IPF) is a serious condition that causes the tiny air sacs in the lungs (known as the alveoli) and the surrounding tissue to become damaged. (medic8.com)
  • Cryptogenic and idiopathic both mean of unknown cause, while fibrosis means thickening and scarring. (medic8.com)
  • Idiopathic pulmonary fibrosis is a rare disease and affects fewer than 3 in 10,000 people in the UK and is most common among people aged between 50 and 70. (medic8.com)
  • What causes idiopathic pulmonary fibrosis? (medic8.com)
  • The exact cause of idiopathic pulmonary fibrosis is not known. (medic8.com)
  • What are the symptoms of idiopathic pulmonary fibrosis? (medic8.com)
  • How is idiopathic pulmonary fibrosis diagnosed? (medic8.com)
  • There is currently no cure for idiopathic pulmonary fibrosis, however, treatments are available to suppress and ease symptoms. (medic8.com)
  • What is the outlook for idiopathic pulmonary fibrosis? (medic8.com)
  • The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has stopped one arm of a three arm multi-center, clinical trial studying treatments for the lung-scarring disease idiopathic pulmonary fibrosis (IPF) for safety concerns. (nih.gov)
  • This study, called PANTHER-IPF (Prednisone, Azathioprine, and N-acetylcysteine: A Study that Evaluates Response in Idiopathic Pulmonary Fibrosis) was designed and conducted by the Idiopathic Pulmonary Fibrosis Clinical Research Network, funded by the NHLBI. (nih.gov)
  • Retroperitoneal fibrosis is best described as a chronic inflammatory process which may be idiopathic, but can rarely be brought about by medications, such as pergolide, used for treating Parkinson's disease. (biomedcentral.com)
  • I recently rewatched a TED talk video that I related to after receiving my idiopathic pulmonary fibrosis diagnosis . (pulmonaryfibrosisnews.com)
  • Although retroperitoneal fibrosis is associated with aortic vascular disease, regional malignancy, or even primary immune-inflammatory syndromes (eg, systemic lupus erythematosus, vasculitis, auto-immune pancreatitis), its origin is usually idiopathic or of unknown cause, with speculations indicating an immune origin. (medindia.net)
  • Recent Research - In a recent well organized study, a total of 76 patients with idiopathic retroperitoneal fibrosis were randomly assigned, to two groups for maintenance treatment for RPF -one was treated with tamoxifen and another with a tapering schedule of corticosteroids. (medindia.net)
  • An international research team led by members of the University of Colorado School of Medicine faculty has identified a genetic connection between rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis. (news-medical.net)
  • Veracyte, Inc. announced the presentation of data demonstrating that the Envisia Genomic Classifier can help physicians more confidently diagnose interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF), without the need for surgery. (news-medical.net)
  • Results from INPULSIS-ON, published today in Lancet Respiratory Medicine, provide insights into the long-term safety, efficacy, and tolerability of Ofev (nintedanib) in patients with idiopathic pulmonary fibrosis (IPF). (news-medical.net)
  • A scientific team led by Cedars-Sinai has been awarded $12 million from the National Institutes of Health to investigate two deadly lung conditions: idiopathic pulmonary fibrosis and chronic lung allograft dysfunction. (news-medical.net)
  • Idiopathic pulmonary fibrosis (IPF) is a serious lung disease. (webmd.com)
  • You can have idiopathic pulmonary fibrosis for a long time without noticing any symptoms. (webmd.com)
  • Idiopathic pulmonary fibrosis (IPF) is a rare, progressive illness of the respiratory system, characterized by the thickening and stiffening of lung tissue, associated with the formation of scar tissue. (wikipedia.org)
  • There is some evidence that viral infections may be associated with idiopathic pulmonary fibrosis and other fibrotic lung diseases. (wikipedia.org)
  • Over time, overloaded hearts typically become larger (a process called compensatory hypertrophy) to deal with the increased pressure. (sciencemag.org)
  • If prolonged, as occurs in untreated hypertension, the pressure overload leads to pathological hypertrophy and fibrosis, and ultimately leading to heart failure. (sciencemag.org)
  • found that mice with a cardiomyocyte-specific deficiency of RhoA, a GTP (guanosine 5′-triphosphate)-regulated protein, developed increased pathological hypertrophy but reduced fibrosis with chronic cardiac stress. (sciencemag.org)
  • Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hype. (biomedsearch.com)
  • In the inducible transgenic group, MMI ‐0100 treatment reduced cardiac fibrosis, decreased cardiac hypertrophy, and prolonged survival. (ahajournals.org)
  • Provides proof of principle that MMI‐0100 treatment reduced cardiac fibrosis, decreased cardiac hypertrophy, and prolonged survival under conditions where the primary disease‐causing peptide was continually made. (ahajournals.org)
  • However, the role of miR-154 in a model of sustained pressure overload-induced cardiac hypertrophy and fibrosis had not been assessed. (nature.com)
  • To examine the role of miR-154 in the diseased heart, adult male mice were subjected to transverse aortic constriction for four weeks and echocardiography was performed to confirm left ventricular hypertrophy and cardiac dysfunction. (nature.com)
  • In summary, this study suggests that miR-154 may represent a novel target for the treatment of cardiac pathologies associated with cardiac fibrosis, hypertrophy and dysfunction. (nature.com)
  • Cardiac hypertrophy in response to sustained increases in blood pressure or pressure overload due to aortic stenosis typically leads to adverse cardiac remodelling including left ventricular (LV) dilatation, cardiac fibrosis and the progression to heart failure (HF). (nature.com)
  • Their data show that chronic over stimulation of the system (which happens after a heart attack) prompts hypertrophy a thickening and enlargement of the heart muscle. (medicaldialogues.in)
  • The major factor in heart failure during aging is heart remodeling, including long-term stress-induced cardiac hypertrophy and fibrosis. (oncotarget.com)
  • Analyses of protein from rat heart tissues and sections revealed cardiac inflammation, hypertrophy and fibrosis pathway increases in aged rat groups (A12 and A18), which were improved in exercise training groups (AE12 and AE18). (oncotarget.com)
  • These data suggest that moderate swimming exercise training attenuated aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts. (oncotarget.com)
  • Patients had a transthoracic echocardiogram to assess whether they had structural heart disease (ventricular hypertrophy, systolic or diastolic dysfunction, or pulmonary hypertension). (innovations-report.com)
  • Nearly half of patients (47%) had some form of structural heart disease, mainly left ventricular hypertrophy, left ventricular dysfunction, pulmonary hypertension and signs of right ventricle failure (see figure). (innovations-report.com)
  • Proceeds go toward families dealing with cystic fibrosis. (dailynews.com)
  • It is found to be an independent predictor for the progression of heart failure, which accounts for approximately 450,000 deaths per year in the United States. (eurekalert.org)
  • With these findings, we may have an entirely new way to stop that slow but steady progression of heart failure that affects 24 million people worldwide," says Deepak Srivastava, MD , president and senior investigator at Gladstone and senior author of the study. (trdrp.org)
  • Fibrosis is a pivotal player in heart failure development and progression. (nih.gov)
  • Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, and its treatment may be effective in preventing heart failure and its progression. (nih.gov)
  • Here, we investigate the anti-inflammatory and anti-fibrotic effects of E2 on reversing the adverse remodeling of the left ventricle which occurs during the progression to heart failure. (ahajournals.org)
  • Interstitial fibrosis plays a key role in the development and progression of heart failure. (quanterix.com)
  • Currently the most widely-used methods for monitoring the progression of cystic fibrosis involve studying slow changes in pulmonary function. (genomeweb.com)
  • In a mouse model that closely simulates the disease progression in humans after a heart attack, the researchers blocked G? (medicaldialogues.in)
  • Experimental and clinical studies suggest that the vascular endothelium may play an important role in modulating the progression of ventricular and vascular remodeling in heart failure (HF). (ahajournals.org)
  • Further study of the impact of estrogen on fibrosis progression in NASH patients is needed. (medindia.net)
  • A common denominator of chronic kidney disease is fibrosis and determines disease progression. (americanheart.org)
  • There is an immediate need to identify therapeutic targets, which can stop or delay progression of fibrosis. (americanheart.org)
  • In the proposed project, we will study the role of STAT3 transcriptional repositioning in kidney cell specific STAT3 null mice (proximal tubular or pericytes knockout) during AKI to fibrosis progression. (americanheart.org)
  • These studies support a kidney-heart connection in early renal dysfunction resulting in progressive ventricular dysfunction, remodeling and fibrosis. (ahajournals.org)
  • In the present study, we assessed the influences of H2R disruption on left ventricular (LV) dysfunction and the mechanisms involved in mitochondrial dysfunction and calcineurin-mediated myocardial fibrosis. (portlandpress.com)
  • Because cardiovascular disease remains a serious problem in modern human society, the aim of this study was to establish the rat model animal and to compare the heart dysfunction and fibrosis with SD and LE rats when treated with myocardial ischemia and reperfusion operation. (ajol.info)
  • Cardiac fibrosis is critically involved in the adverse remodeling accompanying dilated cardiomyopathies (DCMs), which leads to cardiac dysfunction and heart failure (HF). (biologists.org)
  • Dilated cardiomyopathy (DCM) is the most common type of non-ischemic cardiomyopathy, and is characterized by dilation and contractile dysfunction of the left and right ventricles, which is associated with functional alterations leading to heart failure (HF). (biologists.org)
  • Here, we show that an enzyme that crosslinks collagen-Lysyl oxidase-like 2 (Loxl2)-is essential for interstitial fibrosis and mechanical dysfunction of pathologically stressed hearts. (quanterix.com)
  • Cardiac fibrosis is an important contributor to the pathophysiology of LV systolic and diastolic dysfunction. (onlinejacc.org)
  • To investigate a direct effect of gallein on the kidney, we used a bilateral ischemia-reperfusion AKImousemodel, inwhich gallein attenuated renal dysfunction, tissue damage, fibrosis, inflammation, and ET systemactivation. (elsevier.com)
  • Patients with systemic sclerosis show preserved systolic function, high frequency of cardiac fibrosis, diastolic dysfunction and subendocardic concentric perfusion defects, related to microvascular damage. (biomedcentral.com)
  • Collectively, these previous studies revealed the compound has significant promise for treating cardiac dysfunction and fibrosis. (medicaldialogues.in)
  • Four weeks after the initial cardiac injury, control mice showed signs of significant fibrosis and heart dysfunction, although targeted G? (medicaldialogues.in)
  • Such fibrosis causes the heart to stiffen so that it cannot adequately fill with blood and then empty itself, a condition known as diastolic dysfunction. (emaxhealth.com)
  • Diabetic cardiomyopathy refers to diabetes-associated structural and functional myocardial dysfunction not related to other confounding traditional factors such as coronary artery disease (CAD), hypertension, congenital heart diseases or valvular heart diseases [ 1-3 ]. (escardio.org)
  • Using novel MRI methods to quantify diffuse myocardial fibrosis in-vivo, we aim to: 1) demonstrate fibrosis and its association with cardiovascular dysfunction in specific ACHD subgroups, 2) relate fibrosis to aldosterone and changes in collagen synthesis, and then 3) prove its role by quantifying the interval change in fibrosis after a year of spironolactone and correlating this with collagen synthesis and structural change. (grantome.com)
  • Purpose: Hepatic dysfunction is common in patients with cardiomyopathy being evaluated for heart transplant (HT). (atcmeetingabstracts.com)
  • Dr Montoro said: "It is well known that patients with HIV have a high incidence of structural heart disease (mainly diastolic dysfunction and pulmonary hypertension) as measured by echocardiography but the reason is not clear. (innovations-report.com)
  • Clinical trials for the treatment showed positive results in over 3000 men that it was tested on, and unlike other sexual dysfunction medication, it is said to be usable by men suffering from diabetes or heart problems and those who have undergone a prostatectomy. (wikipedia.org)
  • Abstract-Heart failure (HF) commonly results in atrial fibrillation (AF) and fibrosis, but how the distribution of fibrosis impacts AF dynamics has not been studied. (psu.edu)
  • abstract = "The subject of this dissertation is the role of non-coding RNA (ncRNA) in the development of heart failure. (maastrichtuniversity.nl)
  • Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase? (nih.gov)
  • Cystic fibrosis , which fills the lungs with a clogging mucus, can be the most devastating disease. (mirror.co.uk)
  • Cystic fibrosis is a life-shortening genetic condition, which causes the internal organs, especially the lungs and digestive system, to become clogged with thick sticky mucus, resulting in chronic infections and inflammation of the lungs. (heart.co.uk)
  • Expression of miR-154 is upregulated in the diseased heart and was previously shown to be upregulated in the lungs of patients with pulmonary fibrosis. (nature.com)
  • CHAPEL HILL - An imbalance of salt and water in patients with cystic fibrosis makes their lungs clog up with sticky mucus that is prone to infection. (healthcanal.com)
  • Clarifying this link between the genetic defect and the thick sticky mucus in cystic fibrosis lungs could help researchers develop better therapies. (healthcanal.com)
  • Cystic fibrosis is a chronic disorder characterized by a buildup of mucus in the lungs and other parts of the body, and various types of lung infection are responsible for about 85 percent of deaths in these patients. (healthcanal.com)
  • And it's not only the airways and lungs that are affected in a person who has cystic fibrosis. (rchsd.org)
  • In a normal heart, the right side pumps oxygen-depleted, or blue blood from other parts of the body to the lungs to get more oxygen. (sungazette.com)
  • This can be complicated by a second problem the Kimmel baby has - pulmonary atresia, a severely blocked heart valve, which prevents enough blood from reaching the lungs. (sungazette.com)
  • As medical specialists learn more about the virus and how it affects the human body, alarming complications are becoming evident including life-threatening blood clots in the lungs, heart and brain of COVID-19 patients. (alfredhealth.org.au)
  • Cystic Fibrosis (CF) is an inherited genetic condition, which mainly affects the lungs, digestive system and the sweat glands. (angelfire.com)
  • This data strongly suggests that one of the mechanisms for the beneficial action of estrogen on left ventricular heart failure is through reversal of inflammation and fibrosis. (ahajournals.org)
  • But the collagen quality (via CCL) correlated well at baseline with left ventricular ejection fraction, diastolic function, and N-terminal pro-B-type natriuretic peptide, and with risk of hospitalization for heart failure (HHF) over 7 years. (onlinejacc.org)
  • The increase in fibrosis did not lead to a significant change in the fibrosis percentage of left ventricular mass among treated patients. (musculardystrophynews.com)
  • Diabetic cardiomyopathy has been previously differentiated into two phenotypes, namely restrictive or heart failure with preserved left ventricular ejection fraction (HFPEF) and dilated or heart failure with impaired or reduced left ventricular ejection fraction (HFREF). (escardio.org)
  • PURPOSE OF REVIEW: The clinical importance of fibrosis in hypertensive heart disease is now well recognized. (mendeley.com)
  • SUMMARY: Myocardial fibrosis in hypertensive heart disease remains an area of intensive research. (mendeley.com)
  • Whereas recent work has expanded our knowledge of the underlying processes in the development of this fibrosis, additional scientific and clinical research is required to assist clinical risk assessment and to provide evidence that therapeutic intervention confers improved clinical outcome in hypertensive heart disease. (mendeley.com)
  • OPN, PCP, and LOX were assessed by histochemical and molecular methods in the myocardium of 21 patients with hypertensive heart disease (HHD) and HF. (nih.gov)
  • SINGAPORE, 12 September 2019 - Using cutting-edge technologies, researchers at Duke-NUS Medical School, Singapore, have developed the first genome-wide dataset on protein translation during fibroblast activation, revealing a network of RNA-binding proteins (RBPs) that play a key role in the formation of disease-causing fibrous tissue in the heart. (eurekalert.org)
  • Heart disease is a prominent cause of mortality, accounting for one in three deaths in Singapore. (eurekalert.org)
  • But under stress-from injury, cardiovascular disease, or aging-the heart thickens and stiffens in a process known as fibrosis, which involves diffuse scar-like tissue. (trdrp.org)
  • Researchers knew that in mice with heart disease, blocking a class of proteins known as BET proteins slowed fibrosis and improved heart function, although it wasn't clear which cell type in the heart was being affected. (trdrp.org)
  • The incidence of the risk factors for heart disease increased among the rats that were exposed to smoke. (belmarrahealth.com)
  • Cardiac fibrosis, the excessive accumulation of extracellular matrix (ECM), remains an unresolved problem in most forms of heart disease. (mdpi.com)
  • They are activated by the disease-associated changes in mechanical properties of the heart, including stretch and increased tissue stiffness. (mdpi.com)
  • Wineland's struggle with cystic fibrosis was well documented, providing a direct look at a debilitating disease that few people ever see who are not directly affected. (dailynews.com)
  • These results suggest that sGC stimulator BAY 41-2272 might be effective to reduce fibrosis in hypertensive heart disease by attenuating angiotensin II generation through myofibroblast transformation. (biomedsearch.com)
  • However, few reports have described its use in evaluating liver fibrosis in children with congenital heart disease (CHD). (nih.gov)
  • A tendency for ischaemic heart disease to precede IPF in the majority of cases suggests the possibility that broader systemic or cardiac-specific factors may influence the pathogenesis of these pulmonary disorders. (bmj.com)
  • Lung transplantation remains the final therapeutic option for end stage lung disease in cystic fibrosis. (bmj.com)
  • Testing of the cell‐permeant peptide inhibitor MMI‐0100 efficacy in ameliorating cardiac fibrosis in a well‐defined model of sarcomere protein caused cardiac disease. (ahajournals.org)
  • Cardiovascular disease can be caused by and is often accompanied by alterations in cardiac fibrosis. (ahajournals.org)
  • Unlike oncology, we do not split heart failure into subtypes on the basis of disease pathways (4) . (onlinejacc.org)
  • Myocardial fibrosis is an attractive biomarker-fibrosis is already an established marker in the liver, kidneys, and lung-and likely a causal disease pathway mediating outcomes. (onlinejacc.org)
  • Cardiac fibrosis can be measured on myocardial biopsy and tracks disease severity and outcome (5,6) . (onlinejacc.org)
  • The pathologic cascade that eventuates in irreversible fibrosis, characteristic of this autoimmune-associated cardiac disease, has been difficult to define at the molecular level. (biomedcentral.com)
  • Systemic sclerosis (SSc) is an autoinmune disease characterized by tissue fibrosis and microvascular damage. (biomedcentral.com)
  • To determine the prevalence of heart involvement in a cohort of patients with SSc, to describe the patterns of heart involvement in these patients using cardiac MRI, and to correlate these data with disease subsets and target organ involvement. (biomedcentral.com)
  • This deal reflects CFFTI''s focus on discovering biomarkers for monitoring the condition of infants diagnosed with cystic fibrosis, and for assessing the efficacy of treatments for the disease during clinical trials. (genomeweb.com)
  • While proteomics is not the only avenue that CFFTI has chosen to pursue its research, Beall said the foundation has alighted upon the discipline because of its potential for uncovering disease pathways, and for mapping out the interactions of the proteins involved in the disease, including the protein encoded by the CFTR gene, which is known to be associated with cystic fibrosis. (genomeweb.com)
  • This alleviated the disease processes in mouse models of human heart failure, and in cardiac cells isolated from heart failure patients undergoing reparative surgery. (medicaldialogues.in)
  • Adult congenital heart disease is also a growing concern for clinicians and researchers at Cincinnati Children's, who are developing new clinical and research strategies for adults who were pediatric heart patients. (medicaldialogues.in)
  • Cystic fibrosis patients with the most severe disease have very little of the CFTR protein, and this affects the way chloride ions move across many tissues in the body. (healthcanal.com)
  • Thus aldosterone and salt treatment in uninephrectomized rats led to severe hypertension and the development of a vascular inflammatory phenotype in the heart, which may represent one mechanism by which aldosterone contributes to myocardial disease. (physiology.org)
  • The recent identification of the mineralocorticoid receptor in the heart ( 18 ), blood vessels ( 30 ), and brain ( 35 ) raises the possibility that aldosterone may have additional direct actions on these target organs of hypertensive disease, independent of "classic" renal and blood pressure effects of mineralocorticoids. (physiology.org)
  • Cystic fibrosis (CF) is a disease that causes the body to make thick, sticky mucus (say: MYOO-kus). (rchsd.org)
  • People with CF got the disease because their moms and dads each had a gene for CF. You need two CF genes (one from mom and one from dad) to have cystic fibrosis. (rchsd.org)
  • Treating Duchenne and Becker's muscular dystrophy patients with angiotensin-converting enzyme (ACE) blocking drugs at early disease stages may slow the development of heart fibrosis and, as a consequence, offer patients a better prognosis. (musculardystrophynews.com)
  • Tagged angiotensin-converting enzyme (ACE) inhibitors , Cardiovascular magnetic resonance , heart disease , heart fibrosis . (musculardystrophynews.com)
  • Event benefiting the Kevin W. Lynch Heart Disease Research Fund celebrates the life of family patriarch following a fatal heart attack. (uhhospitals.org)
  • Diabetes mellitus (DM) is today one of the leading causes of heart failure in current clinical practice, independent of other traditional risk factors for cardiovascular diseases and heart failure such as atherosclerosis, coronary artery or valvular heart disease. (escardio.org)
  • Dr. Broberg has obtained sub-specialty training in adult congenital heart disease (ACHD), and cardiac MRI. (grantome.com)
  • ISHLT guidelines highlight the need for liver evaluation in patients with restrictive cardiomyopathy, congenital heart disease or chronic viral hepatitis, but do not specify a method for evaluation. (atcmeetingabstracts.com)
  • Survivors of Fontan palliation for single ventricle congenital heart disease may excel at home, work and school, but nonetheless face a lifetime of medical complications, including the development of early heart failure. (chaoc.org)
  • Non-alcoholic fatty liver disease (NAFLD) includes a range of liver disorders from simple fatty liver to inflammation, fibrosis, and cirrhosis. (medindia.net)
  • Heart disease, AIDS, and Lupus no more? (newsblaze.com)
  • The Framingham Heart Study, the nation's longest running cohort study with longitudinal analysis of cardiovascular disease, has been renewed for an additional six years and $38 million dollars from the National Heart, Lung, and Blood Institute. (news-medical.net)
  • A lung transplant often remains the only option for many patients with end-stage lung disease, a condition that can be brought on by emphysema, pulmonary fibrosis, cystic fibrosis and other lung disorders. (news-medical.net)
  • The researchers believe this confirms that the repair cells may provide new therapies for patients with heart disease. (regenhealthsolutions.info)
  • The heart is known for its very limited capacity to repair itself making heart disease the number one cause of death in North America. (regenhealthsolutions.info)
  • Our discovery of a new cell that can help heal injured heart muscle will open the door to new therapies and hope for the millions of people who suffer from heart disease. (regenhealthsolutions.info)
  • The Mission of the Cystic Fibrosis Foundation, a nonprofit donor foundation, is to assure the development of the means to cure and control cystic fibrosis and to improve the quality of life for those with the disease. (uthscsa.edu)
  • HIV causes structural heart disease according to research presented at EuroEcho-Imaging 2013 by Dr Nieves Montoro from Madrid, Spain. (innovations-report.com)
  • We decided to conduct a study to evaluate whether the stage of HIV or the detectable blood viral load were related to the degree of heart disease. (innovations-report.com)
  • Dr Montoro said: "We found that half of HIV patients with dyspnea had echocardiographic evidence of structural heart disease. (innovations-report.com)
  • Our most interesting finding was that patients with a positive blood viral load had a significantly higher incidence of structural heart disease. (innovations-report.com)
  • In fact, having a detectable blood viral load nearly doubled the prevalence of heart disease, suggesting that HIV itself might be an independent causal agent. (innovations-report.com)
  • The amount of structural heart disease was not affected by whether or not the patient had AIDS, their gender, age, or presence of cardiovascular risk factors, although this is still a preliminary result and will have to be confirmed in further analysis. (innovations-report.com)
  • Our findings show that having any detectable level of virus in the blood nearly doubles the risk of heart disease. (innovations-report.com)
  • Dr Montoro continued: "Because of the high incidence of cardiac problems in our study (almost 50%) we think that all HIV patients with dyspnoea should undergo a transthoracic echocardiogram to check for structural heart disease. (innovations-report.com)
  • Furthermore, patients with a positive blood viral load are at nearly twice the risk of structural heart disease and they should receive an echocardiogram whether they are symptomatic or not. (innovations-report.com)
  • Patients found to have a detectable blood viral load and/or structural heart disease should have closer follow up by a cardiologist and their HIV specialist doctor. (innovations-report.com)
  • Back in January the European Medicines Agency's Committee for Medicinal Products for Human Use rejected Novartis' application for serelaxin, calling out the development team for failing to demonstrate quick relief for heart disease in the first 24 hours, failing to demonstrate the significance of the benefit over 5 days and calling into question the data that were presented. (fiercebiotech.com)
  • Regular physical activity makes you less likely to have a heart attack or develop heart disease. (heartfoundation.org.au)
  • The Heart Foundation is a national leader in research into the causes, treatment and prevention of heart disease and related disorders. (heartfoundation.org.au)
  • This is primarily useful when the threat of premature closure of the ductus arteriosus exists in an infant with ductal-dependent congenital heart disease, including cyanotic lesions (e.g., hypoplastic left heart syndrome, pulmonary atresia/stenosis, tricuspid atresia/stenosis, transposition of the great arteries) and acyanotic lesions (e.g., coarctation of the aorta, critical aortic stenosis, and interrupted aortic arch). (wikipedia.org)
  • The fibrosis in IPF has been linked to cigarette smoking, environmental factors (e.g. occupational exposure to gases, smoke, chemicals or dusts), other medical conditions including gastroesophageal reflux disease (GERD), or to genetic predisposition (familial IPF). (wikipedia.org)
  • CCN5, a matricellular protein, has been found to reverse established cardiac fibrosis in heart failure models, according to a study led by Roger J. Hajjar, MD, Professor of Medicine and Director of the Cardiovascular Research Center at the Icahn School of Medicine at Mount Sinai, and Woo Jin Park, PhD, Professor of Life Sciences at the Gwangju Institute of Science and Technology (GIST), South Korea. (eurekalert.org)
  • At our Cardiovascular Research Center, we are dedicated to making significant strides in developing potential bench-to-bedside treatments for heart failure and other cardiovascular diseases. (eurekalert.org)
  • Our aim was to determine, in patients with heart failure (HF) and cardiac dyssynchrony, whether ECCM biomarkers are influenced by CRT and can predict cardiovascular outcomes and response to CRT. (nih.gov)
  • Cardiac fibrosis is a hallmark of cardiovascular remodeling associated with hypertension. (biomedsearch.com)
  • Fibrosis can occur in many cardiovascular diseases, and mitogen‐activated protein kinase--activated protein kinase‐2 signaling has been implicated in a variety of fibrotic processes. (ahajournals.org)
  • Researchers at the University of São Paulo Medical School in Brazil previously had investigated heart fibrosis in the two types of muscular dystrophies with the help of cardiovascular magnetic resonance scans. (musculardystrophynews.com)
  • MICARDIS is equally effective as the current standard, ramipril, in reducing the risk of cardiovascular death, myocardial infarction, stroke and hospitalization for congestive heart failure. (emaxhealth.com)
  • It is caused by a defect in the gene that codes for a protein called cystic fibrosis transmembrane conductance regulator or CFTR. (healthcanal.com)
  • Interstitial Fibrosis in Heart Failure , edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. (ebooks.com)
  • The Architecture of the Heart: Myocyte Organization and the Cardiac Extracellular Matrix. (ebooks.com)
  • Prospects for Gene Therapy for the Fibrosed Heart: Targeting Regulators of Extracellular Matrix Turnover. (ebooks.com)
  • Atrial fibrillation (AF) is the most common sustained arrhythmia in adults and is often associated with congestive heart failure (HF), which induces extracellular matrix remodeling involving atrial fibrosis and dilatation. (ahajournals.org)
  • Cardiac Fibrosis hardens the ventricles, impeding cardiac contraction-relaxation and separates cardiomyocytes from the extracellular matrix, impairing electrical coupling [ 2 ]. (imedpub.com)
  • Histamine H 2 receptor (H2R) blockade has been reported to be beneficial for patients with chronic heart failure (CHF), but the mechanisms involved are not entirely clear. (portlandpress.com)
  • 5 In addition, chronic AF patients have an increased propensity to develop fibrosis at the posterior left atrium (PLA). (ahajournals.org)
  • We hypothesized that MMI ‐0100 might also be protective in a chronic model of fibrosis, produced as a result of cMyBP ‐C 40k cardiomyocyte expression. (ahajournals.org)
  • Development ofCKDsecondary to chronic heart failure (CHF), known as cardiorenal syndrome type 2 (CRS2), clinically associates with organ failure and reduced survival. (elsevier.com)
  • Heart and kidney damage in CRS2 results predominantly from chronic stimulation of G protein-coupled receptors (GPCRs), including adrenergic and endothelin (ET) receptors, after elevated neurohormonal signaling of the sympathetic nervous systemand the downstream ET system, respectively. (elsevier.com)
  • Patients suffering from chronic heart failure (CHF) have increased endogenous catecholamine level, resulting in substantial alterations in β-AR signaling [ 8 ]. (imedpub.com)
  • While there is an association between liver fibrosis and heart failure, the mechanisms for this association are currently unclear but may be of particular importance for people living with human immunodeficiency virus (HIV) and/or hepatitis C, both of which are chronic infections that affect the liver and heart. (scienceweekdigest.com)
  • The signature histologic lesion of autoimmune-associated congenital heart block is fibrosis of the conducting tissue, and in some cases the surrounding myocardium. (biomedcentral.com)
  • One of the strongest clinical associations with autoantibodies (Ab) directed to components of the SSA/Ro-SSB/La ribonucleoprotein complex is the development of congenital heart block (CHB) in an offspring. (biomedcentral.com)
  • [1] In babies with congenital heart defects , it is used by slow injection into a vein to open the ductus arteriosus until surgery can be carried out. (wikipedia.org)
  • Diseases of the heart muscle are common ailments in both pediatric and adult populations, and research by the Blaxall group has revealed many are linked to heart tissue fibrosis. (medicaldialogues.in)
  • Magnetic resonance elastography (MRE) recently emerged as a technique to clinically evaluate liver fibrosis. (nih.gov)
  • MRE is a highly sensitive tool that can evaluate liver fibrosis in children who undergo the Fontan procedure and enable earlier detection of LS than biomarkers. (nih.gov)
  • A new study published in the online edition of Hepatology suggests that estrogen plays an important role in protecting women from with nonalcoholic steatohepatitis (NASH) from severe liver fibrosis, which means that men are at a greater risk of more severe fibrosis compared to pre-menopausal women though the severity is similar in men and post-menopausal women. (medindia.net)
  • Antibody-mediated inhibition or genetic disruption of Loxl2 greatly reduces stress-induced cardiac fibrosis and chamber dilatation, improving systolic and diastolic functions. (quanterix.com)
  • Many of our current measurements are partial surrogates for fibrosis (e.g., imaging for cardiac remodeling, systolic and diastolic function), but more are needed, particularly circulating blood biomarkers. (onlinejacc.org)
  • There was also greater fibrosis present in the kidneys. (belmarrahealth.com)
  • After adjusting for known predictors of fibrosis, the risk for greater fibrosis severity in post-menopausal women and men vs. pre-menopausal women was 1.4-fold and 1.6-fold, respectively. (medindia.net)
  • Furthermore, when dividing the cohort at age 50, which is the average age at menopause in the US, the risk for greater fibrosis severity in men vs. women before age 50 was 1.8-fold, while after the age 50 the risk was reduced to 1.2-fold. (medindia.net)
  • Early research shows that taking Saccharomyces boulardii by mouth does not reduce yeast infections in the digestive tract of people with cystic fibrosis. (medlineplus.gov)
  • This protein is defective in cystic fibrosis, producing the thick, sticky mucus that causes problems for people with CF. (rchsd.org)
  • A team of investigators led by members of the University of Colorado School of Medicine faculty at CU Anschutz Medical Campus has identified a connection between mucus in the small airways and pulmonary fibrosis. (news-medical.net)
  • The genetic mutation underlying cystic fibrosis (CF) causes mucus that should be thin and slick to become mucky and thick, and makes the sweat expel more salt than a healthy person's would. (merkuri.us)
  • Now, researchers at the University of North Carolina at Chapel Hill School of Medicine have found the answer, demonstrating that the gene mutated in cystic fibrosis not only controls traffic on the chloride highway, but also keeps the sodium highway from being overused. (healthcanal.com)
  • Researchers looked at cardiac fibrosis, which can occur in patients who have suffered an infection of the heart muscle or a heart attack. (emaxhealth.com)
  • and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis. (ebooks.com)
  • Therapeutic Potential of TIMPs in Heart Failure. (ebooks.com)
  • The therapeutic efficacy of CCN5 continues to be investigated in pre-clinical models of heart failure with extensive fibrosis. (eurekalert.org)
  • Despite the serious risk and high prevalence of cardiac fibrosis, existing therapies are ineffective and there is an unmet need for new therapeutic approaches to prevent, limit, or reverse the condition. (eurekalert.org)
  • Cardiac fibrosis is one of the leading causes of heart failure and therapeutic options are limited. (imedpub.com)
  • To evaluate its therapeutic potential against cardiac fibrosis, male Wistar rats were injected with isoproterenol (5 mg/ kg) for 8-12 weeks and the aqueous TA extract was administered orally. (imedpub.com)
  • THE Cystic Fibrosis Foundation has lined up yet another big gun in the proteomics field to zero in on potential protein biomarkers and therapeutic targets: After signing research collaborations with Proteome Systems and Affinium Pharmaceuticals, the drug discovery arm of the Cystic Fibrosis Foundation has now turned to Oxford Glycosciences as its third commercial partner in proteomics. (genomeweb.com)
  • Under the agreement, CFFTI retains exclusive rights to develop therapeutics for cystic fibrosis from any discoveries OGS makes, and OGS will have exclusive rights to develop databases, prognostic and diagnostic products, and to pursue therapeutic applications outside of cystic fibrosis. (genomeweb.com)
  • Thus, targeting genes such as microRNAs (miRNAs), that are regulated by the cardioprotective kinase PI3K(p110α), may represent a promising therapeutic approach to improve function of the failing heart. (nature.com)
  • Researchers report encouraging preclinical results as they pursue elusive therapeutic strategies to repair scarred and poorly functioning heart tissues after cardiac injury describing an experimental molecular treatment for heart failure. (medicaldialogues.in)
  • The limited data available support the hypothesis that aldosterone-mediated fibrosis is present and thus a potential therapeutic target. (grantome.com)
  • In an article published online by Frontiers in Endocrinology, researchers at the Medical University of South Carolina report that they have identified a potential therapeutic target for lung fibrosis or scarring. (news-medical.net)
  • RECENT FINDINGS: This article further confirms the involvement of the renin-angiotensin system in cardiac fibrosis and illustrates the supportive roles of mineralocorticoids, endothelin, and novel signaling pathways. (mendeley.com)
  • Diagnostic Tools for the Identification of Myocardial Fibrosis and Changes in Ventricular Mechanics. (ebooks.com)
  • The amount of ventricular fibrosis proved to be increased relative to WT. (ovid.com)
  • ARTICLE{Tanaka_2007spatial, author = {Kazuhiko Tanaka and Sharon Zlochiver and Karen L. Vikstrom and Masatoshi Yamazaki and Javier Moreno and Matthew Klos and Alexey V. Zaitsev and Ravi Vaidyanathan and David S. Auerbach and Steve L and Jose ́ Jalife and Omer Berenfeld}, title = {2007 Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure}, journal = {Circ. (psu.edu)
  • During AF in failing hearts, heterogeneous spatial distribution of fibrosis at the PLA governs AF dynamics and fractionation. (psu.edu)
  • Here we have characterized how AF frequency and dynamics on the endocardial surface of the PLA and pulmonary vein ostia (PVO) are affected by the amount, type (ie, diffuse versus patchy), and spatial distribution of fibrosis in failing hearts. (ahajournals.org)
  • We investigated whether the pro-fibrotic matricellular protein osteopontin (OPN) is associated with the enzymes involved in the extracellular synthesis of fibril-forming collagen type I (i.e. procollagen C-proteinase, PCP) and its cross-linking to form insoluble fibrils (i.e. lysyl oxidase, LOX) in heart failure (HF) of hypertensive origin. (nih.gov)
  • However, the heart is just one intermediate-sized organ releasing markers of (non-organ-specific) collagen pathways into the bloodstream. (onlinejacc.org)
  • total collagen content in heart increases and interstitial fibrosis onsets [ 4 ]. (imedpub.com)
  • Age-related cardiac remodeling and fibrosis was mitigated in MnSOD Tg mice with reductions in extramyocyte space (-65%), collagen-I, and transforming growth factor-β. (inha.ac.kr)
  • RESULTS: Interstitial fibrosis with cross-linked collagen is prominent in HF hearts, with presence of activated MyoFbs. (researchportal.be)
  • IPF is believed to be the result of an aberrant wound healing process including/involving abnormal and excessive deposition of collagen (fibrosis) in the pulmonary interstitium with minimal associated inflammation. (wikipedia.org)
  • Cardiac fibrosis is also a main driver of heart failure with preserved ejection fraction (HFpEF) as it increases myocardial stiffness, thereby compromising the distensibility of the ventricles and impairing the filling capacity of the heart [ 10 ]. (mdpi.com)
  • Currently, we are part of a clinical trial involving the implantation of an inter-atrial septal device (from CORVIA) to reduce left atrial pressure in patients with heart failure with preserved ejection fraction. (alfredhealth.org.au)
  • The objective of this First-in-Human evaluation is to assess the safety and effectiveness of catheter-based unilateral ablation of the greater splanchnic nerve in subjects having heart failure with preserved ejection fraction (HFpEF). (alfredhealth.org.au)
  • Cost-effective strategies to identify this subgroup of patients are of great interest, as outlined in the American College of Cardiology and American Heart Association guidelines ( 4 ). (onlinejacc.org)
  • In an Aug. 22 study in the Journal of the American College of Cardiology, researchers at the Cincinnati Children's Heart Institute inhibited a protein that helps regulate the heart's response to adrenaline. (medicaldialogues.in)
  • Srivastava's group studied mice who developed heart failure, and treated them daily with a BET inhibitor for 1 month. (trdrp.org)
  • The researchers used single-cell RNA sequencing and single-cell epigenomics-which can reveal which genes in a cell are accessible and being turned on at any given time-to compare heart cells from mice before, during, and after the treatment, and correlate those results with heart function. (trdrp.org)
  • In particular, the researchers discovered that the gene MEOX1 was highly active in the mice with heart failure and that its levels dramatically dropped when the mice were treated with the BET inhibitor. (trdrp.org)
  • We have previously shown that short-term estrogen (E2) treatment can rescue pressure overload-induced decompensated heart failure (HF) in mice. (ahajournals.org)
  • Transgenic mice overexpressing a continuously active form of calcineurin in the heart (MHC-CnA) displayed conduction abnormalities and increased arrhythmia vulnerability relative to wildtype (WT). (ovid.com)
  • Hearts were extracted from young (8 months) wild-type, young mice overexpressing the Sod2 (MnSOD) gene, old (28 months) wild-type, and old transgenic mice. (inha.ac.kr)
  • In a second group of mice, the Blaxall team genetically removed the GRK2 protein shortly after cardiac injury from either cardiomyocytes (the contractile/functional cells of the heart). (medicaldialogues.in)
  • The research group showed that rapamycin , an existing drug known to stimulate this cell-survival process, called autophagy , helped control B. cenocepacia infection in mice that serve as a model for cystic fibrosis. (healthcanal.com)
  • The special cell, called Gata6+ pericardial cavity macrophage, has been found to help heal injured hearts in mice. (regenhealthsolutions.info)
  • In mice, it has been found to help heal injured hearts. (regenhealthsolutions.info)
  • We found that STAT3 deletion from pericytes protects mice from kidney fibrosis. (americanheart.org)
  • The patient developed retroperitoneal fibrosis resulting in renal failure from ureteral obstruction necessitating ureteral stenting, as well as significant aortic and mitral valve insufficiency. (biomedcentral.com)
  • Retroperitoneal fibrosis improved with pergolide cessation and corticosteroid treatment. (biomedcentral.com)
  • Retroperitoneal fibrosis (RPF) is a rare inflammatory and sclerosing disorder that affects the tissues around the lower aorta, causing obstruction to the upper urinary tract and organs of the digestive tract. (medindia.net)
  • Third, control with corticosteroid treatment is shown in the form of reduction in the symptoms of retroperitoneal fibrosis, reduction in RPF as shown by imaging studies and normalization of acute phase markers (sedimentation rate and C-reactive protein). (medindia.net)
  • Mallory Smith's memoir, Salt in My Soul was published after she died of complications from cystic fibrosis at just 25 in 2017. (merkuri.us)
  • Circulating Biomarkers of Cardiac Fibrosis Do We Have Any and What Use Are They? (ahajournals.org)
  • LOXL2 is also elevated in the serum of heart failure (HF) patients, correlating with other HF biomarkers, suggesting a conserved LOXL2-mediated mechanism of human HF. (quanterix.com)
  • Cystic Fibrosis Foundation Therapeutics (CFFTI), the foundation's non-profit drug discovery division, said last week that it will pay OGS as much as $5.5 million for its services in an effort to discover and validate serum biomarkers and potential therapeutics for cystic fibrosis and its associated pulmonary conditions. (genomeweb.com)
  • While there currently are no effective cardiac fibrosis therapies available, it is considered a valid target for treatment. (eurekalert.org)
  • These findings demonstrate that CCN5 may provide a novel platform for the development of targeted anti-cardiac fibrosis therapies, which could benefit many patients with previously untreatable heart failure. (eurekalert.org)
  • Collectively, these data demonstrate that CCN5 could potentially be used for the development of new anti-cardiac fibrosis therapies. (eurekalert.org)
  • The biology of heart failure is complex and diverse (2) , posing challenges for developing efficacious therapies. (onlinejacc.org)
  • In patients with hypertrophic cardiomyopathy, we used cardiac MRI to demonstrate that although extensive fibrosis is present in the heart, the actual rate of turnover of fibrosis is low, suggesting that anti-fibrotic therapies may require long periods of administration to provide benefit. (alfredhealth.org.au)
  • Previous experimental and clinical work has emphasized a role for fibrosis in arrhythmia maintenance. (ahajournals.org)
  • Despite the current study's promising preclinical findings the authors stress it's too early to say whether the data will translate into clinically beneficial treatments for human heart failure patients. (medicaldialogues.in)
  • Our research is the first to demonstrate the ability to reverse cardiac fibrosis in heart failure models by targeting a specific gene," said Dr. Hajjar. (eurekalert.org)
  • Their new study , published in the journal Nature, suggests that blocking this gene could prevent fibrosis in the heart-and other organs that can similarly fail from stiffening over time. (trdrp.org)
  • This study for the first time demonstrates that in ISO-induced fibrotic heart, TA extract improves cardiac function by regulating various gene regulatory modules. (imedpub.com)
  • Cystic fibrosis (CF) is one of the most common life-shortening genetic disorders, and the CF transmembrane conductance regulator (CFTR) is the major causal gene. (ubc.ca)
  • Because she had two copies of a particular gene, Mallory suffered from cystic fibrosis. (merkuri.us)
  • Now, researchers at Gladstone Institutes have discovered a master switch for fibrosis in the heart. (trdrp.org)
  • Researchers noted that the untreated patients had a significantly larger increase in fibrosis - 10% compared to only 3.1% in the treated group. (musculardystrophynews.com)
  • Also, researchers noted that as fibrosis increased with age, levels of creatine kinase decreased. (musculardystrophynews.com)
  • Researchers also showed that the traditional heart measures chest radiography, electrocardiography, and echocardiography were not sensitive in detecting heart fibrosis. (musculardystrophynews.com)
  • The researchers are now planning on culturing the printed hearts in the lab and "teaching them to behave" like hearts, noted Dvir. (genengnews.com)
  • Researchers at the University of Calgary have discovered a previously unidentified cell population with the power to heal injured hearts. (regenhealthsolutions.info)
  • The authors concluded , "This is a significant and novel finding illustrating the effects of tobacco and nicotine on epigenetic regulation of fibrosis formation in cardiac and renal tissues. (belmarrahealth.com)
  • Even mild experimental renal insufficiency produced by NX results in early cardiac fibrosis and DD independent of neurohumoral activation, HTN, or VO. (ahajournals.org)
  • Renal function temporarily improved, but deteriorated again with worsening fibrosis (figure 1 ). (biomedcentral.com)
  • Multivariable regression analyses showed a positive correlation between syndecan-1 levels and markers of fibrosis and remodeling but no correlation with inflammation markers. (ahajournals.org)
  • Pro-apoptotic markers Bax (-38%) and caspase-3 cleavage (-41%) were reduced and apoptosis (terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-positive nuclei, DNA laddering) was mitigated in MnSOD Tg hearts compared with old wild-type. (inha.ac.kr)
  • The improved cardiac phenotype was associated with attenuation of heart and cardiomyocyte size, less cardiac fibrosis, lower expression of atrial and B-type natriuretic peptide genes, attenuation of profibrotic markers and increased expression of p15 (a miR-154 target and cell cycle inhibitor). (nature.com)
  • We plan to relate the presence and amount of cardiac fibrosis to measurements made during a previously obtained cardiac catheterization, and to markers of fibrosis that may be present in the blood. (chaoc.org)
  • Pathology revealed mild fibrosis in 19, moderate fibrosis in 11 and severe fibrosis in 9. (atcmeetingabstracts.com)
  • There was a trend towards increased mortality in patients with severe fibrosis (hazard ratio 6.3, p=0.07). (atcmeetingabstracts.com)
  • Conclusion: Although abnormal liver imaging was common in patients being evaluated for HT, severe fibrosis was uncommon. (atcmeetingabstracts.com)
  • Because patients with severe fibrosis experienced increased mortality, LB is an important part of the pre-HT liver evaluation. (atcmeetingabstracts.com)
  • Our findings suggest a protective effect from estrogen against development of severe fibrosis," concludes Dr. Suzuki. (medindia.net)
  • It is our hypothesis that patchy rather than diffuse fibrosis contributes to wavebreak and intramural rotor formation, and governs the overall AF frequency and dynamics. (ahajournals.org)
  • Smoking can increase blood pressure and heart rate, reduce blood flow to the kidneys, increase production of angiotensin II, which is produced by the kidneys, narrow the blood vessels to the kidneys, damage arterioles, promote arteriosclerosis of the kidney arteries, and accelerate kidney function loss. (belmarrahealth.com)
  • more than 50 years ago, Selye ( 28 ) reported that exogenous administration of mineralocorticoids in the presence of a high-salt diet produced severe hypertension and vascular inflammatory lesions in the heart, kidney, brain, pancreas, and mesenteric arteries of rats. (physiology.org)
  • These included blood pressure, enlargement of the heart, and development of scar tissue in the heart muscle. (belmarrahealth.com)
  • Having recently identified a segment of the Fontan population with "stiff" ventricles, we are interested in further exploring this population using advanced cardiac MRI techniques, to evaluate for cardiac fibrosis (or scar). (chaoc.org)
  • In the United States more than 30,000 people live with cystic fibrosis and more than 70,000 have the condition worldwide, according to the Cystic Fibrosis Foundation. (dailynews.com)
  • Cystic Fibrosis affects about 30,000 children and adults in the US. (genomeweb.com)
  • Cystic fibrosis affects more than 30,000 children and young adults in the United States. (rchsd.org)
  • Corticosteroid treatment was not linked to the amount of fibrosis at study start, and did not impact the rate of fibrosis development. (musculardystrophynews.com)
  • Among those patients, the team could not see that corticosteroid treatment impacted fibrosis development. (musculardystrophynews.com)
  • (10) investigated patients with a subset of heart failure, hypertensive heart failure. (onlinejacc.org)
  • First, the authors invasively measured on biopsy CCL in health and in 38 hypertensive heart failure patients, who they dichotomized into normal and high CLL groups. (onlinejacc.org)