Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Heart: The hollow, muscular organ that maintains the circulation of the blood.Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.Heart Failure, Systolic: Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.Heart Failure, Diastolic: Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.Stroke Volume: The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Heart Transplantation: The transference of a heart from one human or animal to another.Adrenergic beta-Antagonists: Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.Ventricular Function, Left: The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Natriuretic Peptide, Brain: A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Cardiac Pacing, Artificial: Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.Ventricular Remodeling: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Heart Atria: The chambers of the heart, to which the BLOOD returns from the circulation.Cardiotonic Agents: Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Heart Function Tests: Examinations used to diagnose and treat heart conditions.Myocardial Contraction: Contractile activity of the MYOCARDIUM.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Propanolamines: AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).Myocytes, Cardiac: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Evidence-Based Practice: A way of providing health care that is guided by a thoughtful integration of the best available scientific knowledge with clinical expertise. This approach allows the practitioner to critically assess research data, clinical guidelines, and other information resources in order to correctly identify the clinical problem, apply the most high-quality intervention, and re-evaluate the outcome for future improvement.Ontario: A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)Sensation Disorders: Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Postural Balance: A POSTURE in which an ideal body mass distribution is achieved. Postural balance provides the body carriage stability and conditions for normal functions in stationary position or in movement, such as sitting, standing, or walking.
A trial of the drug in heart failure was stopped as an interim analysis showed a possible increase in heart failure deaths, in ... As a result of these pharmacokinetic characteristics, dronedarone dosing may be less complicated than amiodarone. Permanent AF ... Recently decompensated heart failure requiring hospitalization or Class IV heart failure. Second-or third-degree AV block or ... stating that dronedarone is contraindicated in patients with NYHA Class IV heart failure, with NYHA Class II-III heart failure ...
"Dose Ranging Study of Celivarone with Amiodarone as Calibrator for the Prevention of Implantable Cardioverter Defibrillator ( ... European Journal of Heart Failure Supplements. 2 (1): 53-54. doi:10.1016/S1567-4215(03)90164-0. "Double Blind Placebo ... They can manifest as slow (bradycardia) or fast (tachycardia) heart rate, and may have a regular or irregular rhythm. The ... The non-iodinated nature of celivarone means that the harmful side-effects on the thyroid commonly seen with amiodarone therapy ...
Chronic heart failure Anemia-due to decrease in blood volume Amiodarone high cumulative dose; more than 400 milligrams per day ...
Daily dose = (Css)ave × Cl × 1440 / ( S x F ) This those is decreased by 25% in patients with heart and/or liver failures, and ... Also amiodarone, cimetidine and trimethoprim increase the NAPA serum level. Cimetidine and ranitidine possibly increase plasma ... Bauer LA, Black D, Gensler A (1989). "Influence of age, renal function, and heart failure on procainamide clearance and n- ... In short-term and more prolonged studies, acecainide 1.5 to 2.0 g as a single dose or as three or four divided doses a day ...
... leading to congestive heart failure. The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4 ... Other groups of drugs that cause this problem include antimalarials, amiodarone, heavy metals (but not iron), tetracyclines, ... when the dose of doxorubicin is 500-550 mg/m², 18% when the dose is 551-600 mg/m² and 36% when the dose exceeds 600 mg/m². ... including risk of cardiac failure manifesting as congestive heart failure (CHF). Published phase II study results have shown ...
Heart failure Left ventricular hypertrophy Hypothermia Subarachnoid hemorrhage Hypothyroidism The ECG tracing in torsades ... related to a potential risk of abnormal heart rhythms with high doses" (Press release). USFDA. February 15, 2013. Retrieved ... Examples of compounds linked to clinical observations of TdP include amiodarone, fluoroquinolones, methadone, lithium, ... Heart Inst. J. 39 (1): 68-70. PMC 3298934 . PMID 22412232. K Zivin; PN Pfeiffer; ASB Bohnert; D Ganoczy; FC Blow; BK Nallamothu ...
... congestive heart failure, or recent angina, the wide complex tachycardia is much more likely to be ventricular tachycardia. The ... High-dose magnesium is often used as an antidote in cardiac arrest protocols. The diagnosis of ventricular tachycardia is made ... Evidence does not show that amiodarone is better than procainamide. As a low magnesium level in the blood is a common cause of ... and the Heart Rhythm Society (HRS); in collaboration with the American College of Cardiology (ACC) and the American Heart ...
... of developing congestive heart failure liver failure, sometimes fatal The cyclodextrin used to make the syrup preparation can ... In the United States, as of 2017, the wholesale cost of this dose is 6.36 USD. Itraconazole has a broader spectrum of activity ... "Cardiac arrest provoked by itraconazole and amiodarone interaction: a case report". Katzung & Trevor's (2015). Pharmacology ... Severe side effects may include liver problems, heart failure, Stevens-Johnson syndrome and allergic reactions including ...
Cardiorespiratory failure Digoxin may be prescribed for a child to treat heart defects. Possible side effects in children are: ... Digoxin Commonly used website to calculate empiric digoxin doses for medical purposes for heart problems Protein Data Bank ... Amiodarone, some benzodiazepines, cyclosporine, diphenoxylate, indomethacin, itraconazole, propafenone, quinidine, quinine, ... Often lowering the dose is considered by the prescriber. The side effects related to toxicity are used to assess the ...
Tingling will start at the point of absorption and extend up the arm to the shoulder, after which the heart will start to be ... Marked symptoms may appear almost immediately, usually not later than one hour, and "with large doses death is almost ... Other drugs used for ventricular arrhythmia include lidocaine, amiodarone, bretylium, flecainide, procainamide, and mexiletine ... caused by oral ingestion and even handling the plant without gloves has been reported to result in multi-organ failure and ...
A further study focused on rhythm control in patients with AF and simultaneous heart failure, based on the premise that AF ... "Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: ... Chemical cardioversion is performed with drugs, such as amiodarone, dronedarone, procainamide, ibutilide, propafenone or ... Furthermore, AF with a persistent rapid rate can cause a form of heart failure called tachycardia-induced cardiomyopathy. This ...
However, though the heart rate slowing in proportional to the (low) dose of atropine, the increase in HRV varies widely across ... including congestive heart failure, diabetic neuropathy, depression, post-cardiac transplant, susceptibility to SIDS and poor ... Flecainide and propafenone but not amiodarone were reported to decrease time domain measures of HRV in patients with chronic ... Heart. 88: 378-380. doi:10.1136/heart.88.4.378. Clinton F. Goss; Eric B. Miller (August 2013). "Dynamic Metrics of Heart Rate ...
September 1999). "Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations ... The incidence of torsades de pointes is 0.3-10.5% and is dose-related, with increased incidence associated with higher doses. ... and does not have the pulmonary or hepatotoxicity of amiodarone, however atrial fibrillation is not generally considered life- ... September 1999). "Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations ...
Heart failureEdit. Digoxin is no longer the first choice for heart failure; it has fallen out of favor in people with heart ... The doctor speculates that she may have taken high doses of digoxin to die of heart attack. There are hints that she may have ... Examples commonly used in patients with heart problems include spironolactone, verapamil and amiodarone. In patients with ... For congestive heart failure, levels between 0.5 and 1.0 ng/ml are recommended.[20] This recommendation is based on post hoc ...
... probably due to heart failure). Congestive heart failure (CHF) is characterized by a reduction in ventricular performance and ... Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone), trade name Inocor, is a pyridine ... Thrombocytopenia is the most prominent and dose-related side effect, but it is transient and asymptomatic. Nausea, diarrhoea, ... "Withdrawal of long-term amrinone therapy in patients with congestive heart failure: a placebo controlled trial". European Heart ...
... ischemic heart disease or heart failure. Flecainide intoxication is rare but serious due to the cardiogenic shock that it ... the dosing of flecainide may need to be adjusted in individuals who develop either liver failure or renal failure. Because of ... may further depress normal heart function Amiodarone - inhibits cytochrome P450 2D6 and may increase flecainide levels ... and may worsen congestive heart failure in these individuals. It should be avoided in people with ischaemic heart disease and ...
Heart Failure Society of America guidelines for heart failure provide similar recommendations. Despite its relatively recent ... decreased heart rate) or tachycardia (increased heart rate), depending on the dose and the condition of one's heart. Notably, ... amiodarone, can worsen the dysrhythmia caused by digitalis, therefore, the second-choice drug lidocaine is more commonly used.[ ... especially if they have been diagnosed with congestive heart failure. Digoxin was approved for heart failure in 1998 under ...
"Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans". Ann. Intern. Med. 78 (4): ... A lower dose may be required in those with liver problems. It is generally safe to use in those allergic to tetracaine or ... if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and ... The volume of distribution is 1.1 L/kg to 2.1 L/kg, but congestive heart failure can decrease it. About 60% to 80% circulates ...
25 mg/day (low-dose therapy) is just as good as 75 mg/day (high-dose therapy). Primidone is not the only anticonvulsant used ... 1999 reported that one of their treatment failures, a 45-year-old woman taking 50 mg a day along with lithium 600 mg/day, ... 25% of the thirty-two cases had congenital heart defects; the reported rate in cleft lip and palate was 3-5%. Meadow emphasized ... CYP2C8 substrates such as amiodarone, paclitaxel, pioglitazone, repaglinide, and rosiglitazone; and CYP2C9 substrates such as ...
2005). "Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure". N Engl J Med. 352 (3): 225-37. ... especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. Glucocorticoids ... Chronic heart failure: management of chronic heart failure in adults in primary and secondary care. Clinical Guideline 5. ... Jan 2014). "New devices in heart failure: an European Heart Rhythm Association report: developed by the European Heart Rhythm ...
Use of higher doses of radioiodine reduces the incidence of treatment failure, with penalty for higher response to treatment ... Thyroid storm is a severe form of thyrotoxicosis characterized by rapid and often irregular heart beat, high temperature, ... Amiodarone, an antiarrhythmic drug, is structurally similar to thyroxine and may cause either under- or overactivity of the ... A very high dose is often needed early in treatment, but, if too high a dose is used persistently, patients can develop ...
There is a failure to suppress in the manic phase of bipolar disorder. Many people may develop a thyroid nodule at some point ... Higher than normal doses are often administered to prevent recurrence. If the thyroid gland must be removed surgically, care ... Common hypothyroid symptoms include fatigue, low energy, weight gain, inability to tolerate the cold, slow heart rate, dry skin ... Amiodarone (more commonly can lead to hypothyroidism, but can be associated with some types of hyperthyroidism) Lithium salts ( ...
... in elderly people and in high doses (> 30 mg per day). A clinical sign of domperidone's potential toxicity to the heart is the ... QT-prolonging drugs like amiodarone. Prolactin secreting pituitary tumor (prolactinoma) or hyperprolactinemia. Mechanical bowel ... was born at 28 weeks gestation with respiratory complications and had a fundoplication for gastroesophageal reflux and failure ... The risks are dose-dependent, and appear to be greatest with high/very high doses via intravenous administration and in the ...
... can also not be used in patients with heart failure, permanent pacemaker, or other significant ischemic heart ... 60 mg dose,) and its terminal half life is 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose).[24] ... time Curve) are dose dependent. The Cmax and Tm (time needed to obtain the maximum plasma concentration) after single doses of ... Phase III studies in men with PE showed a safety and well tolerate profile of dapoxetine with dosing of 30 and 60 mg. There is ...
12.4 Medicines used in heart failure. *12.5 Antithrombotic medicines *12.5.1 Anti-platelet medicines ... Fixed-dose combinations[edit]. *Abacavir/lamivudine. *Dolutegravir/lamivudine/tenofovir (dolutegravir + lamivudine + tenofovir) ... Also listed for single-dose treatment of trachoma and yaws. *^ Third-generation cephalosporin of choice for use in hospitalized ... Other combinations that deliver the target doses required such as 153 mg or 200 mg (as hydrochloride) with 50 mg artesunate can ...
... wears off quickly after dosing. Unboosted indinavir requires a very precise dosing of 400 mg every eight hours to ... American Heart Journal. 150 (5): 933.e1-933.e7. doi:10.1016/j.ahj.2005.06.005. PMID 16290967.. ... which sometimes may lead to more severe condition including kidney failure ... Indinavir cost about $12 for a daily dose, which is 24% less than Invirase and 33% less than Norvir.[14] Because the company ...
3 Pulmonary toxicity is a diagnosis of exclusion and other conditions including heart failure, infectious pneumonia, pulmonary ... Amiodarone is an anti-arrhythmic medicine.2 When initiated, a loading dose is required to reduce the time taken for amiodarone ... high-dose amiodarone and a case report suggests this discolouration will resolve within a year if the total daily dose is ... ensure the patient understands that the loading dose is taken only for the initiation period, so that high-dose amiodarone is ...
In some patients, for example those with mild heart failure, digitalisation may be achieved more slowly with doses of 250 to ... amiodarone, flecainide, prazosin, propafenone, quinidine, spironolactone, macrolide antibiotics e.g. erythromycin and ... In some patients, for example those with mild heart failure, digitalisation may be achieved more slowly with doses of 250 to ... The total loading dose should be administered in divided doses with approximately half of the total dose given as the first ...
Heart failure. Atrial fibrillation and atrial flutter (slows ventricular rate). Paroxysmal atrial tachycardia. High Alert ... PatientDigoxin is used to treat certain heart problems such as some arrhythmias Digoxin Lanoxin. These are signs that the dose ... There may be a role High Alert Medications , Medical Error , …of high-risk/high alert Digoxin • Amiodarone • Adams-Babineau. ... QuizletHeart failure. Atrial fibrillation and atrial flutter (slows ventricular rate). Paroxysmal atrial tachycardia. High ...
... stiff heart or diastolic dysfunction. When you have A-Fib, do you automatically have diastolic heart failure? What exactly is ... Neville writes that "taking a heavy dose of Magnesium/Potassium tablets and bananas for breakfast kept him out of A-Fib during ... See the personal A-Fib story by Kris: "Binge Drinking Leads to Chronic A-Fib, Amiodarone Damages Eyesight" pp. 144-150 in my ... Heart Problems. If youve had other heart problems, this could lead to diseased heart tissue which generates the extra A-Fib ...
Pharmacologic therapy.Digoxin is used for treating heart failure and slowing the heart rate in patients with chronic atrial ... cyclosporin, amiodarone)that increase digoxin toxicity).Voraxaze (glucarpidase) is an antidote indicated for the treatment of ... 62 5mg is there a heavier dose mite 0.0625 mg does nolvadex increase fertility in men digoxin 250 mcg oral tab. ... Junctional Bradycardia as Early Sign of Digoxin Toxicity in a Premature Infant with Congestive Heart Failure due to a Left to ...
Randomized trial of low-dose amiodarone in severe congestive heart failure. Lancet. 1994;344:493-498. ... In the Veterans Affairs Congestive Heart Failure Amiodarone Study,23 after 2 weeks of therapy, 33% of patients on amiodarone ... For low-dose amiodarone, high-dose amiodarone, and bretylium, these rates were 1.68, 0.48, and 0.96 events per 24 hours, ... placebo-controlled trial of low-dose amiodarone in patients with severe heart failure and asymptomatic frequent ventricular ...
High dose oral amiodarone loading exerts important hemodynamic actions in patients with congestive heart failure. J Am Coll ... Randomised trial of low-dose amiodarone in severe congestive heart failure. Lancet. 1994;344:493-498. ... and antiarrhythmic effects of long term treatment with amiodarone of patients with heart failure. Br Heart J. 1987;57:436-445. ... Effect of Amiodarone on Clinical Status and Left Ventricular Function in Patients With Congestive Heart Failure. Barry M. ...
Renal Functions and Prognosis Stratification in Chronic Heart Failure Patients and the Importance of Neutrophil Gelatinase- ... Plasma cholesterol was not related to the daily dose of amiodarone or to plasma concentrations of amiodarone, ... An Increase in Plasma Cholesterol Independent of Thyroid Function during Long-Term Amiodarone Therapy: A Dose-Dependent ... Conclusion: Long-term amiodarone treatment is associated with a dose-dependent increase in plasma cholesterol that is ...
Low dose amiodarone in congestive heart failure.. Alves LE, Rose EP.. J Am Coll Cardiol. 1991 Jun;17(7):1672-3. No abstract ... Use of nifedipine in older patients and patients with congestive heart failure. ... Am Heart J. 1993 Jun;125(6):1808-9. No abstract available. ... Adverse effects of amiodarone.. Alves LE, Rose EP, Klingele TG ...
Use of low-dose amiodarone has also been advocated for the treatment of congestive heart failure in patients with severely ... To the Editors: For several years, we have used low-dose amiodarone (≤ 200 mg/d) in the treatment of patients with ... A Proposed Trial of Amiodarone for Atrial Fibrillation Larry E. Alves, MD; Edward P. Rose, MD ... A Proposed Trial of Amiodarone for Atrial Fibrillation. Ann Intern Med. ;117:972-973. doi: 10.7326/0003-4819-117-11-972 ...
Amiodarone side effects are scary. This drug requires cautious management! ... Amiodarone is FDA-approved for extremely hard-to-treat heart rhythm disturbances. ... I could only take 6 doses of this poison before shortness of breath and congestive heart failure set in. Even though I stopped ... I was given amiodarone after flu that left me with heart failure. It was given in the hospital by an IV which gave me horrible ...
Severe heart failure (New York Heart Association class IV); patients with a dose of ,80 mg frusemide or equivalent ... Amiodarone, however, which was originally introduced in France as an antianginal drug, may also be of benefit.50 Angiotensin ... Management of heart failure. Figure 7 summarises present management of heart failure, but several clinical trials in heart ... How to recognise heart failure. Heart failure is not a diagnosis in itself. The patient usually but not always has a history of ...
... treatment with low dose amiodarone (1000 mg/week) plus titrated doses of carvedilol (target 50 mg/day) was instituted. In ... Combination therapy with carvedilol and amiodarone in patients with severe heart failure. Eur J Heart Failure2000;2:71-9. ... Dual chamber pacing in patients with severe heart failure on β blocker and amiodarone treatment: preliminary results of a ... Dual chamber pacing in patients with severe heart failure on β blocker and amiodarone treatment: preliminary results of a ...
A trial of the drug in heart failure was stopped as an interim analysis showed a possible increase in heart failure deaths, in ... As a result of these pharmacokinetic characteristics, dronedarone dosing may be less complicated than amiodarone. Permanent AF ... Recently decompensated heart failure requiring hospitalization or Class IV heart failure. Second-or third-degree AV block or ... stating that dronedarone is contraindicated in patients with NYHA Class IV heart failure, with NYHA Class II-III heart failure ...
... continued to receive nonantiarrhythmic therapy for heart failure. The amiodarone group (n = 260) received amiodarone at a dose ... In another large amiodarone trial involving milder heart failure Congestive Heart Failure-Survival Trial of Antiarrhythmic ... baseline heart rate. CHF. congestive heart failure. CHF-STAT. Congestive Heart Failure-Survival Trial of Antiarrhythmic Therapy ... 1989) Beneficial effects of low dose amiodarone in patients with congestive heart failure: a placebo-controlled trial. J Am ...
Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association Full Text ... 0.1 mg/kg for the first dose, followed by 0.2 mg/kg on repeated doses) is the treatment of choice. Verapamil should be avoided ... Consider the use of lidocaine instead of amiodarone (...) ) ● HR < 180 (children) ● Variable beat-to-beat ● HR changes with ... Evaluation and Management of Right-Sided Heart Failure drawn from the end-systolic to end-diastolic PV relationship (to end- ...
For most patients with mild-to-moderate heart failure, low-dose digoxin may be as effective as higher doses. If side effects ... Digitalis also interacts with many other drugs, including quinidine, amiodarone, verapamil, flecainide, amiloride, and ... Failure on the Left Side (Left-Ventricular Heart Failure). Failure on the left side of the heart is more common than failure on ... Other diseases that damage or weaken the heart muscle or heart valves can also cause heart failure. Heart failure is most ...
Doval and colleagues (3, 4) conducted a trial of low-dose amiodarone in patients with heart failure. The study was randomized, ... 3. Doval HC, Nul DR, Grancelli HO, et al. Randomised trial of low-dose amiodarone in severe congestive heart failure. Lancet. ... with no signs of heart failure and a 2% risk for death in the next 30 days, and a 72-year old man with heart failure and a 50% ... 4. Amiodarone did not reduce mortality in severe congestive heart failure. ACP J Club. 1995;122:33. ...
... amiodarone, n=2; sotalol, n=1), Aldactone (n=6), digoxin (n=3), and furosemide (n=9). The study was performed with written ... The effect of carvedilol on morbidity and mortality in patients with chronic heart failure: US Carvedilol Heart Failure Study ... Regional Sympathetic Effects of Low-Dose Clonidine in Heart Failure. Anuradha Aggarwal, Murray D. Esler, Margaret J. Morris, ... Clonidine, at modest doses, significantly attenuates cardiac and renal sympathetic tone in heart failure. In addition to the ...
Atrial tachycardia can be observed in persons with normal hearts and in those with structurally abnormal hearts, including ... Before administering amiodarone, control the ventricular rate and congestive heart failure (if present) with digoxin or calcium ... Flecainide blocks sodium channels, producing a dose-related decrease in intracardiac conduction in all parts of the heart. This ... Digitalis in toxic doses can cause atrial tachycardia. In therapeutic doses, digitalis may be useful in some focal atrial ...
Bradycardia, hypotension, worsening heart failure/fluid retention may occur. Reduce the dose as needed. (5.2, 5.3, 5.4) ... Amiodarone: In a pharmacokinetic study conducted in 106 Japanese patients with heart failure, coadministration of small loading ... 5.4 Heart Failure/Fluid Retention. Worsening heart failure or fluid retention may occur during up-titration of carvedilol. If ... These dose levels produced placebo-corrected heart rate reduction of 4-6 heart beats per minute, indicative of β-blockade ...
"Dose Ranging Study of Celivarone with Amiodarone as Calibrator for the Prevention of Implantable Cardioverter Defibrillator ( ... European Journal of Heart Failure Supplements. 2 (1): 53-54. doi:10.1016/S1567-4215(03)90164-0. "Double Blind Placebo ... They can manifest as slow (bradycardia) or fast (tachycardia) heart rate, and may have a regular or irregular rhythm. The ... The non-iodinated nature of celivarone means that the harmful side-effects on the thyroid commonly seen with amiodarone therapy ...
Randomised trial of low-dose amiodarone in severe congestive heart failure. Grupo de Estudio de la Sobrevida en la ... The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin. Smith, J.W., Longo, D.L., ... The effects of high-dose corticosteroids in patients with septic shock. A prospective, controlled study. Sprung, C.L., Caralis ... High-dose carboplatin (800 mg per square meter of body-surface area) was administered alone to a control group [38]. ...
... amiodarone can be safely administered in patients with structural heart disease, including patients with heart failure. ... Sotalol is renally eliminated and therefore the dose should be adjusted accordingly. ... AF can occur in the absence of an obvious heart abnormality (idiopathic or lone AF) or secondary to heart failure, valvular, or ... The prevalence of AF increases in patients with congestive heart failure or valvular heart disease. ...
... amiodarone can be safely administered in patients with structural heart disease, including patients with heart failure. ... Dose-Escalation Mitigates Risk of Grade 3/4 Adverse Events With Ruxolitinib for Myelofibrosis ... AF can occur in the absence of an obvious heart abnormality (idiopathic or lone AF) or secondary to heart failure, valvular, or ... The prevalence of AF increases in patients with congestive heart failure or valvular heart disease. ...
  • Vaughan Williams class IC (eg, flecainide, propafenone) or class III (eg, sotalol, amiodarone) agents have been prescribed with variable success. (medscape.com)
  • A more aggressive practitioner could argue that the results provide more support for treatment than we have for many of our widely used interventions and that administration of amiodarone is therefore appropriate. (acpjc.org)
  • Verapamil works by slowing down the movement of calcium through muscle cells that are found in the heart and the walls of blood vessels. (netdoctor.co.uk)
  • As verapamil improves this oxygen supply, and also reduces the effort the heart has to make to pump blood, it can be used to prevent angina attacks. (netdoctor.co.uk)
  • Verapamil is also used to slow down certain types of abnormally fast heartbeats, which could otherwise seriously undermine the pumping action of the heart and result in inefficient blood circulation around the body. (netdoctor.co.uk)
  • Reduction of K+ current by 69% led to increased AP duration and increased effective refractory periods, thus shown to suppress pacemaker potential of the SA node and return patients to a normal heart rhythm. (wikipedia.org)
  • The rise in plasma cholesterol was associated with an equal increase in apoprotein B. Plasma cholesterol was not related to the daily dose of amiodarone or to plasma concentrations of amiodarone, desethylamiodarone, thyroxine (T4), triiodothyronine (T3), or reverse triiodothyronine (rT3). (annals.org)
  • For seniors, people with liver problems, and people taking the medications omeprazole or cimetidine, the maximum recommended daily dose is 10 mg. (medbroadcast.com)
  • It is important to determine whether underlying structural heart disease is present and left ventricular function is impaired. (aafp.org)
  • or heart, liver, or kidney disease. (medlineplus.gov)
  • Obtain baseline and periodic liver transaminases and discontinue or reduce dose if the increase exceeds three times normal, or doubles in a patient with an elevated baseline. (drugs.com)
  • When taking Multaq, patients often develop liver failure and a worsening of their heart conditions. (gregjoneslawblog.com)
  • If you or a loved one have developed liver failure or a worsening of your heart condition after using Multaq, contact attorney Greg Jones today for a free consultation. (gregjoneslawblog.com)
  • Amiodarone injection loading infusions at much higher concentrations and rates of infusion much faster than recommended have resulted in hepatocellular necrosis and acute renal failure , leading to death (see PRECAUTIONS , Liver Enzymes Elevations ). (rxlist.com)
  • The combination vasodilator regimen of hydralazine plus isosorbide dinitrate significantly prolonged survival in the first Veteran Affairs Heart Failure Trial (V-HeFT) ( ), but to a lesser degree than an angiotensin-converting enzyme inhibitor in V-HeFT II ( ), and there are no data to indicate that these approaches have additive benefit. (onlinejacc.org)
  • Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. (medbroadcast.com)
  • If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. (medbroadcast.com)
  • A side effect is an unwanted response to a medication when it is taken in normal doses. (medbroadcast.com)
  • This medication contains two medications that work in different ways to counteract the effects of heart failure. (hoag.org)
  • This medication works by reducing heart rate and is only indicated for patients with a regular heart beat and those who cannot take beta blockers or are on maximum dose beta blockers. (hoag.org)
  • He was stabilised on conventional heart failure medication and discharged back to his local hospital. (bcs.com)
  • Some reactions such as extreme sun-sensitivity are clearly a side effect of medication, but other feelings such as confusion or memory loss may be part of having heart failure. (healthtalk.org)
  • But one of the things I have noticed is with my medication, I thought it was something getting stuck in my throat and dissolving in my throat, which is why when I was having the heart attacks I never took any notice of the discomfort because I thought it was one of my tablets had dissolved in my throat. (healthtalk.org)
  • Doubling or tripling the dose of a medication by impeding its metabolism means unintended impact. (peoplespharmacy.com)
  • In addition to the beneficial effects of antiadrenergic therapy in the heart, the renal sympatholytic effect may counter the salt and water retention that is a hallmark of the condition. (ahajournals.org)
  • Counselling: reduce dose if renal impairment, take shortly after food. (flashcardmachine.com)
  • discontinue if acute renal failure develops and consider alternate therapy. (renalandurologynews.com)
  • At a dose of 3 μg/kg/min the effects are predominantly dopaminergic and produce an increase in renal blood flow. (ctsnet.org)
  • At doses above 10 μg/kg/min the alpha effects become more apparent with a tendency to increasing vascular resistance and increased afterload with reduced renal blood flow. (ctsnet.org)