RNA, Small Cytoplasmic
Heart Defects, Congenital
Cardiac Pacing, Artificial
Heart Conduction System
Bundle of His
Heart Rate, Fetal
Heart Septal Defects, Ventricular
Lupus Erythematosus, Cutaneous
Lupus Erythematosus, Systemic
Transposition of Great Vessels
Sick Sinus Syndrome
DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. (1/1056)Myotonic dystrophy (DM) is the most common form of muscular dystrophy and is caused by expansion of a CTG trinucleotide repeat on human chromosome 19. Patients with DM develop atrioventricular conduction disturbances, the principal cardiac manifestation of this disease. The etiology of the pathophysiological changes observed in DM has yet to be resolved. Haploinsufficiency of myotonic dystrophy protein kinase (DMPK), DM locus-associated homeodomain protein (DMAHP) and/or titration of RNA-binding proteins by expanded CUG sequences have been hypothesized to underlie the multi-system defects observed in DM. Using an in vivo murine electrophysiology study, we show that cardiac conduction is exquisitely sensitive to DMPK gene dosage. DMPK-/- mice develop cardiac conduction defects which include first-, second-, and third-degree atrioventricular (A-V) block. Our results demonstrate that the A-V node and the His-Purkinje regions of the conduction system are specifically compromised by DMPK loss. Importantly, DMPK+/- mice develop first-degree heart block, a conduction defect strikingly similar to that observed in DM patients. These results demonstrate that DMPK dosage is a critical element modulating cardiac conduction integrity and conclusively link haploinsufficiency of DMPK with cardiac disease in myotonic dystrophy. (+info)
Junctional ectopic tachycardia evolving into complete heart block. (2/1056)Transition from congenital junctional ectopic tachycardia to complete AV block was observed in an 8 month old girl, over a 36 hour period, during initial hospital admission. Two years later she had evidence of a rapidly increasing left ventricular end diastolic diameter, associated with lowest heart rates during sleep of < 30 beats/min. A transvenous permanent pacemaker was therefore implanted. This finding supports the idea that a pathological process in the area of the AV junction, initially presenting as junctional ectopic tachycardia may later extend to sudden complete atrioventricular block. (+info)
Modulation of AV nodal and Hisian conduction by changes in extracellular space. (3/1056)Previous studies have demonstrated that the extracellular space (ECS) component of the atrioventricular (AV) node and His bundle region is larger than the ECS in adjacent contractile myocardium. The potential physiological significance of this observation was examined in a canine blood-perfused AV nodal preparation. Mannitol, an ECS osmotic expander, was infused directly into either the AV node or His bundle region. This resulted in a significant dose-dependent increase in the AV nodal or His-ventricular conduction time and in the AV nodal effective refractory period. Mannitol infusion eventually resulted in Wenckebach block (n = 6), which reversed with mannitol washout. The ratio of AV nodal to left ventricular ECS in tissue frozen immediately on the development of heart block (n = 8) was significantly higher in the region of block (4.53 +/- 0.61) compared with that in control preparations (2.23 +/- 0.35, n = 6, P < 0.01) and donor dog hearts (2.45 +/- 0.18, n = 11, P < 0.01) not exposed to mannitol. With lower mannitol rates (10% of total blood flow), AV nodal conduction times increased by 5-10% and the AV node became supersensitive to adenosine, acetylcholine, and carbachol, but not to norepinephrine. We conclude that mannitol-induced changes in AV node and His bundle ECS markedly alter conduction system electrophysiology and the sensitivity of conductive tissues to purinergic and cholinergic agonists. (+info)
Atrioventricular block occurring several months after radiofrequency ablation for the treatment of atrioventricular nodal re-entrant tachycardia. (4/1056)Atrioventricular (AV) block following radiofrequency (RF) ablation for the treatment of AV nodal re-entrant tachycardia (AVNRT) is a rare but well recognised complication of the procedure--the reported incidence ranges from 1% to 21%. Almost all cases of AV block occur during or shortly after the procedure, are transient, and recover quickly. Two patients (a 22 year man and a 72 year old woman) with symptomatic AV block occurring several months after slow pathway RF ablation, requiring permanent pacemaker implantation, are described. Both patients had had several 24 hour Holter recordings before the procedure, and in neither case was there any evidence of intermittent or persistent AV block. This is a rare complication with no definitive predictors; however, all efforts should be made to exclude AV block in patients presenting with suggestive symptoms following RF ablation. With the wide use of RF ablation for the treatment of AVNRT, more cases are likely to occur. A registry should allow documentation of the incidence of this complication. (+info)
Catheter-induced mechanical trauma to accessory pathways during radiofrequency ablation: incidence, predictors and clinical implications. (5/1056)OBJECTIVES: To evaluate the incidence, predictors and clinical implications of nonintentionally catheter-induced mechanical trauma to accessory pathways during radiofrequency ablation procedures. BACKGROUND: Data on the incidence and significance of catheter-induced trauma to accessory pathways are scarce. METHODS: Consecutive patients (n = 381) undergoing radiofrequency ablation of accessory pathways at two different institutions were closely monitored for appearance of mechanical block of accessory pathways during catheter manipulation. RESULTS: Mechanical trauma to accessory pathways was observed in 37 (9.7%) patients. According to a multivariate analysis, the only independent variable associated with this phenomenon was the anatomical pathway location (p = 0.0001). The incidence of trauma of either right anteroseptal (38.5%) or right atriofascicular pathways (33.3%) was significantly greater than that of pathways (< or =10%) at all remaining locations (p < 0.0001). The duration of conduction block observed ranged from < or =1 min to >30 min in 19% and 35% of patients, respectively. "Immediate" application of radiofrequency pulses at sites of mechanical block (<1 min after occurrence) was associated with a 78% long-term success rate at follow-up. This contrasted with a 25% long-term success rate in patients in whom pulses were delivered 30 min after occurrence of block ("delayed pulses"). Finally, in 24% of patients persistent trauma-induced conduction block led to discontinuation of the ablation procedure. CONCLUSIONS: Trauma to accessory pathways is more common than previously recognized and frequently results in prolongation or discontinuation of the ablation procedure and in lower success rates. The only independent predictor of catheter-trauma to accessory pathways is the pathway location. (+info)
Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulation. (6/1056)BACKGROUND: Recently, it has been reported that connexin40 (Cx40) deficiency in targeted mouse mutants is associated with a prolongation of P-wave and QRS complex duration on surface electrograms. The specific effects of Cx40 deficiency on sinus node function, sinoatrial, and atrioventricular conduction properties as well as on atrial vulnerability have not yet been investigated systematically by electrophysiological analysis. METHODS AND RESULTS: Fifty-two mice (18 Cx40(+/+), 15 Cx40(+/-), and 19 Cx40(-/-) mice) were subjected to rapid atrial transesophageal stimulation after anesthesia with avertin. A significant prolongation of sinus node recovery time was noticed in Cx40(-/-) mice compared with Cx40(+/-) and Cx40(+/+) mice (287.8+/-109.0 vs 211.1+/-61.8 vs 204.4+/-60.9 ms; P<0.05). In addition, Wenckebach periodicity occurred at significantly longer atrial pacing cycle lengths in Cx40(-/-) mice than in Cx40(+/-) or Cx40(+/+) mice (93. 3+/-11.8 vs 83.9+/-9.7 vs 82.8+/-8.0 ms, P<0.05). Analysis of 27 Cx40(-/-) mice showed a significant increase in intra-atrial conduction time and atrioventricular conduction time compared with 52 Cx40(+/-) and 31 wild-type (Cx40(+/+)) mice. Furthermore, in Cx40(-/-) mice, atrial tachyarrhythmias could be induced frequently by atrial burst pacing, whereas no atrial arrhythmias were inducible in heterozygous or wild-type mice. CONCLUSIONS: This study demonstrates that Cx40 deficiency is associated with sinoatrial, intra-atrial, and atrioventricular conduction disturbances. In atrial myocardium of the mouse, Cx40 deficiency results in increased atrial vulnerability and might contribute to arrhythmogenesis. (+info)
Reversion to sinus rhythm 11 years after surgically induced heart block. (7/1056)A patient is presented in whom the heart reverted spontaneously to sinus rhythm 11 years after surgical closure of a ventricular septal defect complicated by complete heart block. It seems unlikely that regeneration of fibres in the bundle of His, if these had indeed been destroyed, could account for the restoration of sinus rhythm after so long an interval. (+info)
Electrophysiological effects of mexiletine in man. (8/1056)The electrophysiological effects of intravenous mexiletine in a dose of 200 to 250 mg given over 5 minutes, followed by continuous infusion of 60 to 90 mg per hour, were studied in 5 patients with normal conduction and in 20 patients with a variety of disturbances of impulse formation and conduction, by means of His bundle electrography, atrial pacing, and the extrastimulus method. In all but 2 patients the plasma level was above the lower therapeutic limit. Mexiletine had no consistent effects on sinus frequency and atrial refractoriness. The sinoatrial recovery time changed inconsistently in both directions; however, of the 5 patients in whom an increase was evident, 3 had sinus node dysfunction. In most patients mexiletine increased the AV nodal conduction time at paced atrial rates and shifted the Wenckebach point to a lower atrial rate. The effective refractory period of the AV node was not consistently influenced, while the functional refractory period increased in 12 out of 14 patients. The HV intervals increased by a mean of 11 ms in 8 patients and were unchanged in 17. Both the relative and effective refractory period of the His-Purkinje system increased after mexiletine. Non-cardiac side effects occurred in 7 out of 25 patients, and cardiac side effects, including one serious, in 2. The results indicate that mexiletine shares some electrophysiological properties with procainamide and quinidine, when given to patients with conduction defects, and that the drug should not be used in patients with pre-existing impairment of impulse formation or conduction. It has additional effects on AV nodal conduction which may be of value in the treatment of re-entrant tachycardias involving the AV node. (+info)
Heart block is a condition in which the electrical signals that regulate the heartbeat are slowed or blocked as they travel through the heart's conduction system. This can cause the heart to beat too slowly (bradycardia) or irregularly, which can lead to symptoms such as dizziness, fainting, and shortness of breath. There are three main types of heart block: first-degree, second-degree, and third-degree. First-degree heart block is the mildest form and usually does not cause any symptoms. Second-degree heart block is more serious and can cause symptoms, especially if it is caused by an underlying heart condition. Third-degree heart block is the most serious form and can lead to life-threatening complications if not treated promptly. Heart block can be caused by a variety of factors, including damage to the heart muscle, certain medications, and inherited conditions. Treatment options depend on the severity of the heart block and the underlying cause. In some cases, a pacemaker may be necessary to regulate the heartbeat.
Adams-Stokes syndrome, also known as pediatric syncope, is a medical condition characterized by recurrent episodes of loss of consciousness (syncope) in children. It is caused by a temporary disruption of blood flow to the brain, which can be due to a variety of factors such as heart problems, low blood pressure, or anemia. The symptoms of Adams-Stokes syndrome may include dizziness, lightheadedness, weakness, and loss of consciousness. The episodes can last from a few seconds to several minutes and may be triggered by physical exertion, emotional stress, or standing up too quickly. Diagnosis of Adams-Stokes syndrome typically involves a thorough medical history and physical examination, as well as various diagnostic tests such as an electrocardiogram (ECG), echocardiogram, and blood tests. Treatment may involve addressing the underlying cause of the syncope, such as treating heart problems or anemia, as well as lifestyle changes and medications to prevent future episodes.
The Atrioventricular (AV) node is a specialized group of cardiac muscle cells located in the wall of the right atrium, between the two atrial chambers of the heart. It acts as a relay station, receiving electrical impulses from the sinoatrial (SA) node in the right atrium and sending them to the ventricles to initiate their contraction. The AV node is responsible for controlling the rate and rhythm of the heartbeat, and any problems with the AV node can lead to arrhythmias or abnormal heart rhythms.
RNA, Small Cytoplasmic, also known as small cytoplasmic RNA (scRNA), is a type of non-coding RNA that is found in the cytoplasm of cells. It is typically between 18 and 30 nucleotides in length and is involved in a variety of cellular processes, including gene expression regulation, RNA stability, and translation. scRNA can be further classified into several subtypes, including microRNAs (miRNAs), small interfering RNAs (siRNAs), and piwi-interacting RNAs (piRNAs), each of which has a distinct function and mechanism of action. In recent years, scRNA sequencing has become a powerful tool for studying the transcriptome of individual cells and has been used to identify novel regulatory mechanisms and to study the heterogeneity of cells within a tissue.
Bradycardia is a medical condition characterized by a slow heart rate, which is defined as a resting heart rate of less than 60 beats per minute (bpm). The normal resting heart rate for adults is typically between 60 and 100 bpm. Bradycardia can be classified as sinus bradycardia, which is a slow heart rate that originates from the sinoatrial node, or as non-sinus bradycardia, which is a slow heart rate that originates from another part of the heart. Bradycardia can be asymptomatic or may cause symptoms such as dizziness, fainting, shortness of breath, chest pain, or palpitations. It can be caused by a variety of factors, including electrolyte imbalances, medications, heart disease, thyroid disorders, and certain genetic conditions. Treatment for bradycardia depends on the underlying cause and the severity of symptoms. In some cases, no treatment may be necessary, while in others, medications, a pacemaker, or other medical procedures may be recommended.
Atrioventricular (AV) block is a type of heart rhythm disorder that occurs when the electrical signals that regulate the heartbeat are delayed or blocked as they travel from the atria (upper chambers) to the ventricles (lower chambers) of the heart. This can cause the heart to beat too slowly or irregularly, which can lead to symptoms such as dizziness, fainting, and shortness of breath. There are three main types of AV block: first-degree, second-degree, and third-degree. First-degree AV block is the mildest form and is characterized by a delay in the electrical signal between the atria and ventricles. Second-degree AV block is more severe and is characterized by a partial blockage of the electrical signal, which can result in a slower heart rate. Third-degree AV block is the most severe form and is characterized by a complete blockage of the electrical signal, which can result in a very slow or irregular heart rate. AV block can be caused by a variety of factors, including damage to the heart muscle, certain medications, and underlying heart conditions such as coronary artery disease or heart failure. Treatment for AV block depends on the severity of the condition and may include medications, a pacemaker, or surgery.
Antibodies, Antinuclear (ANA) are proteins produced by the immune system in response to the presence of foreign substances, such as viruses or bacteria. In the medical field, ANA tests are used to detect the presence of these antibodies in the blood. ANA tests are often used to diagnose autoimmune diseases, which are conditions in which the immune system mistakenly attacks healthy cells and tissues in the body. Some autoimmune diseases that can be diagnosed through ANA testing include lupus, rheumatoid arthritis, and Sjogren's syndrome. ANA tests can also be used to monitor the effectiveness of treatment for autoimmune diseases, as well as to detect the presence of certain infections or other medical conditions. However, it's important to note that a positive ANA test does not necessarily mean that a person has an autoimmune disease, as ANA can also be present in healthy individuals.
Congenital heart defects (CHDs) are structural abnormalities in the heart that are present at birth. These defects can affect the heart's structure, function, or both, and can range from minor to severe. CHDs are the most common type of birth defect and affect approximately 1 in 100 live births. CHDs can occur in any part of the heart, including the valves, arteries, veins, and chambers. Some common types of CHDs include: - Atrial septal defect (ASD): A hole in the wall between the two upper chambers of the heart. - Ventricular septal defect (VSD): A hole in the wall between the two lower chambers of the heart. - Patent ductus arteriosus (PDA): A blood vessel that remains open between the pulmonary artery and the aorta. - Coarctation of the aorta: A narrowing of the aorta, the main artery that carries blood from the heart to the rest of the body. - Tetralogy of Fallot: A combination of four heart defects that affect the flow of blood through the heart. CHDs can cause a range of symptoms, including shortness of breath, fatigue, chest pain, and heart palpitations. Treatment for CHDs depends on the type and severity of the defect, and may include medications, surgery, or other interventions. Early diagnosis and treatment are important for improving outcomes and reducing the risk of complications.
Fetal diseases refer to medical conditions that affect the developing fetus during pregnancy. These conditions can be genetic, infectious, or caused by environmental factors. Fetal diseases can range from minor abnormalities that do not affect the baby's health to life-threatening conditions that require medical intervention. Some common fetal diseases include chromosomal disorders such as Down syndrome, neural tube defects such as spina bifida, and congenital heart defects. Fetal infections such as rubella, cytomegalovirus, and Zika virus can also cause fetal diseases. Environmental factors such as exposure to certain medications, alcohol, or tobacco can also increase the risk of fetal diseases. Fetal diseases can be detected through prenatal testing, such as ultrasound, amniocentesis, or chorionic villus sampling. Early detection and intervention can help improve the outcome for the baby and the mother. Treatment options may include medication, surgery, or other medical interventions, depending on the specific condition and severity.
Cardiac pacing, artificial refers to the medical procedure of implanting a device called a pacemaker into a patient's chest to regulate the heartbeat. The pacemaker is a small electronic device that sends electrical signals to the heart to prompt it to beat at a normal rate. The pacemaker is typically implanted under local anesthesia and can be done on an outpatient basis. The device is connected to the heart through wires called leads, which are placed in the heart's chambers. The pacemaker is then programmed to send electrical signals to the heart at specific intervals to ensure that the heart beats at a normal rate. Artificial cardiac pacing is commonly used to treat patients with bradycardia, a condition in which the heart beats too slowly. It can also be used to treat patients with certain heart conditions, such as heart failure, that cause the heart to beat irregularly. Artificial cardiac pacing can improve a patient's quality of life by reducing symptoms such as fatigue, dizziness, and shortness of breath.
Heart failure, also known as congestive heart failure, is a medical condition in which the heart is unable to pump enough blood to meet the body's needs. This can lead to a buildup of fluid in the lungs, liver, and other organs, causing symptoms such as shortness of breath, fatigue, and swelling in the legs and ankles. Heart failure can be caused by a variety of factors, including damage to the heart muscle from a heart attack, high blood pressure, or long-term damage from conditions such as diabetes or coronary artery disease. It can also be caused by certain genetic disorders or infections. Treatment for heart failure typically involves medications to improve heart function and reduce fluid buildup, as well as lifestyle changes such as a healthy diet, regular exercise, and avoiding smoking and excessive alcohol consumption. In some cases, surgery or other medical procedures may be necessary to treat the underlying cause of the heart failure or to improve heart function.
The Bundle of His is a group of specialized cardiac muscle fibers located in the lower part of the right atrium and the upper part of the right ventricle of the heart. It plays a crucial role in the initiation and conduction of electrical impulses that regulate the heartbeat. The Bundle of His is composed of three main components: the Bundle of His proper, the Right Bundle Branch, and the Left Bundle Branch. The Bundle of His proper is responsible for conducting electrical impulses from the atria to the ventricles, while the Right and Left Bundle Branches conduct the impulses within the ventricles. Any disruption or damage to the Bundle of His can lead to abnormal heart rhythms or arrhythmias.
Heart diseases refer to a group of medical conditions that affect the heart and blood vessels. These conditions can range from minor to severe and can affect the heart's ability to pump blood effectively, leading to a variety of symptoms and complications. Some common types of heart diseases include: 1. Coronary artery disease: This is the most common type of heart disease, which occurs when the arteries that supply blood to the heart become narrowed or blocked due to the buildup of plaque. 2. Heart failure: This occurs when the heart is unable to pump enough blood to meet the body's needs. 3. Arrhythmias: These are abnormal heart rhythms that can cause the heart to beat too fast, too slow, or irregularly. 4. Valvular heart disease: This occurs when the heart valves become damaged or diseased, leading to problems with blood flow. 5. Congenital heart disease: This refers to heart defects that are present at birth. 6. Inflammatory heart disease: This includes conditions such as pericarditis and myocarditis, which cause inflammation of the heart. 7. Heart infections: These include conditions such as endocarditis and myocarditis, which can cause damage to the heart muscle and valves. Treatment for heart diseases depends on the specific condition and may include medications, lifestyle changes, and in some cases, surgery. Early detection and treatment are important for improving outcomes and reducing the risk of complications.
A Bundle-Branch Block (BBB) is a type of heart rhythm disorder that occurs when there is a disruption in the electrical signals that control the contraction of the heart muscle. The heart has two main electrical pathways, called the right and left bundle branches, which carry electrical signals from the sinoatrial node (the heart's natural pacemaker) to the ventricles (the lower chambers of the heart) and cause them to contract and pump blood. A Bundle-Branch Block occurs when there is a delay or blockage in the electrical signals that travel through the bundle branches, causing the ventricles to contract asynchronously or with an abnormal rhythm. This can lead to a variety of symptoms, including palpitations, shortness of breath, dizziness, and fainting. There are two main types of Bundle-Branch Block: Right Bundle-Branch Block (RBBB) and Left Bundle-Branch Block (LBBB). RBBB is more common and usually has no symptoms, while LBBB is less common and can cause more serious symptoms, such as fainting or heart failure. Treatment for Bundle-Branch Block depends on the underlying cause and the severity of the symptoms. In some cases, no treatment may be necessary, while in others, medications or electrical cardioversion may be used to restore a normal heart rhythm. In severe cases, surgery may be necessary to correct the blockage.
Ribonucleoproteins (RNPs) are complexes of RNA molecules and proteins that play important roles in various biological processes, including gene expression, RNA processing, and RNA transport. In the medical field, RNPs are often studied in the context of diseases such as cancer, viral infections, and neurological disorders, as they can be involved in the pathogenesis of these conditions. For example, some viruses use RNPs to replicate their genetic material, and mutations in RNPs can lead to the development of certain types of cancer. Additionally, RNPs are being investigated as potential therapeutic targets for the treatment of these diseases.
In the medical field, "Steroids, Fluorinated" refers to a class of drugs that are synthesized by adding a fluorine atom to the steroid molecule. These drugs are often used to treat a variety of medical conditions, including inflammatory diseases, autoimmune disorders, and certain types of cancer. Fluorinated steroids are similar in structure to natural steroids, such as cortisol and testosterone, but they have different chemical properties that make them more potent and longer-lasting. They are typically administered orally or by injection, and their effects can last for several days or even weeks. Some examples of fluorinated steroids include prednisone, dexamethasone, and triamcinolone. These drugs are often used to treat conditions such as asthma, rheumatoid arthritis, lupus, and multiple sclerosis. However, they can also have side effects, such as weight gain, mood changes, and increased risk of infection, and they should be used under the guidance of a healthcare professional.
Kearns-Sayre Syndrome (KSS) is a rare genetic disorder that affects the muscles and the nervous system. It is caused by mutations in the nuclear DNA of cells, specifically in the mitochondrial DNA. KSS is characterized by a triad of symptoms, which include muscle weakness, pigmentary retinopathy, and cardiac conduction defects. The muscle weakness is usually progressive and can affect the muscles of the face, neck, and limbs. The pigmentary retinopathy can cause vision loss and blindness, while the cardiac conduction defects can lead to arrhythmias and heart failure. KSS is inherited in an autosomal recessive pattern, which means that an individual must inherit two copies of the mutated gene (one from each parent) in order to develop the disorder. There is currently no cure for KSS, but treatment is focused on managing the symptoms and preventing complications.
Endocardial fibroelastosis (EFE) is a rare heart condition that occurs in infants and young children. It is characterized by the abnormal accumulation of fibrous and elastic tissue in the inner lining of the heart's heart chambers (endocardium). This buildup of tissue can obstruct blood flow through the heart and lead to heart failure. EFE is usually diagnosed in infants and young children, and it is more common in boys than girls. The exact cause of EFE is not known, but it is thought to be related to a viral infection or exposure to certain medications during pregnancy. Other risk factors for EFE include prematurity, low birth weight, and a family history of heart disease. Treatment for EFE typically involves medications to manage symptoms and improve heart function. In some cases, surgery may be necessary to remove the excess tissue and improve blood flow through the heart. The prognosis for children with EFE depends on the severity of their condition and how well they respond to treatment. Some children with EFE may recover fully, while others may require ongoing medical care.
Syncope is a medical condition characterized by a temporary loss of consciousness due to a lack of blood flow to the brain. It is also known as fainting or passing out. Syncope can be caused by a variety of factors, including low blood pressure, heart problems, anemia, dehydration, or certain medications. Symptoms of syncope may include dizziness, lightheadedness, weakness, and loss of consciousness. Treatment for syncope depends on the underlying cause and may include lifestyle changes, medications, or medical procedures.
Heart septal defects, ventricular, refer to a type of congenital heart defect that affects the ventricles, which are the lower chambers of the heart responsible for pumping blood out to the body. In a healthy heart, there is a wall called the septum that separates the left and right ventricles. However, in a person with a ventricular septal defect, there is a hole or opening in this wall, allowing blood to flow from one ventricle to the other. This can lead to a variety of symptoms, depending on the size and location of the defect. Some people may not experience any symptoms at all, while others may experience shortness of breath, fatigue, chest pain, or heart palpitations. In severe cases, a ventricular septal defect can lead to heart failure or other complications. Treatment for ventricular septal defects typically involves surgical repair or the placement of a device to close the hole in the septum. The specific treatment approach will depend on the size and location of the defect, as well as the individual's overall health and medical history.
Cardiomyopathies are a group of heart diseases that affect the heart muscle (myocardium). These diseases can cause the heart to become enlarged, thickened, or rigid, which can lead to problems with the heart's ability to pump blood effectively. There are several different types of cardiomyopathies, including: 1. Hypertrophic cardiomyopathy: This is a condition in which the heart muscle becomes abnormally thick, which can make it difficult for the heart to pump blood. 2. Dilated cardiomyopathy: This is a condition in which the heart muscle becomes weakened and enlarged, which can cause the heart to pump blood less effectively. 3. Arrhythmogenic right ventricular cardiomyopathy (ARVC): This is a condition in which the heart muscle in the right ventricle becomes abnormal and can cause irregular heart rhythms. 4. Non-ischemic dilated cardiomyopathy: This is a type of dilated cardiomyopathy that is not caused by a lack of blood flow to the heart muscle. 5. Idiopathic left ventricular hypertrophy: This is a condition in which the left ventricle of the heart becomes abnormally thick, which can make it difficult for the heart to pump blood. Cardiomyopathies can be inherited or acquired, and they can range from mild to severe. Treatment for cardiomyopathies depends on the specific type and severity of the condition, and may include medications, lifestyle changes, and in some cases, surgery.
Lupus erythematosus, cutaneous (LEc) is a type of skin disease that is part of a larger group of conditions known as systemic lupus erythematosus (SLE). SLE is a chronic autoimmune disorder in which the body's immune system attacks healthy cells and tissues, including the skin, joints, kidneys, and other organs. LEc is characterized by a distinctive red rash that appears on the skin, usually on the face, ears, and scalp. The rash is usually symmetrical and can be accompanied by itching, burning, and tenderness. In some cases, the rash may be accompanied by fever, fatigue, and other systemic symptoms. LEc can be a mild condition that resolves on its own, or it can be a more severe form of SLE that requires long-term treatment and management. Treatment for LEc typically involves the use of corticosteroids, immunosuppressive drugs, and other medications to reduce inflammation and suppress the immune system. In some cases, phototherapy or other forms of light therapy may also be used to treat the rash.
In the medical field, an autobiography is a written account of a person's life, including their medical history, experiences, and personal reflections. It may be written by a patient or a healthcare professional, and it can be used for a variety of purposes, such as providing insight into a particular disease or condition, sharing personal stories of overcoming adversity, or educating others about the patient's experience with healthcare. Autobiographies in the medical field may also be used for research purposes, as they can provide valuable data and insights into the lived experiences of patients with specific conditions. They may be used to inform the development of new treatments or to improve patient care and outcomes. Overall, an autobiography in the medical field can be a powerful tool for promoting understanding, empathy, and compassion, as well as for advancing medical knowledge and improving patient care.
Autoantibodies are antibodies that are produced by the immune system against the body's own cells, tissues, or organs. In other words, they are antibodies that mistakenly target and attack the body's own components instead of foreign invaders like viruses or bacteria. Autoantibodies can be present in people with various medical conditions, including autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. They can also be found in people with certain infections, cancer, and other diseases. Autoantibodies can cause damage to the body's own cells, tissues, or organs, leading to inflammation, tissue destruction, and other symptoms. They can also interfere with the normal functioning of the body's systems, such as the nervous system, digestive system, and cardiovascular system. Diagnosis of autoantibodies is typically done through blood tests, which can detect the presence of specific autoantibodies in the blood. Treatment for autoimmune diseases that involve autoantibodies may include medications to suppress the immune system, such as corticosteroids or immunosuppressants, as well as other therapies to manage symptoms and prevent complications.
Hydrops Fetalis is a medical condition that occurs during pregnancy and is characterized by the accumulation of fluid in the fetus's body. This can lead to swelling in the fetus's abdomen, chest, and limbs, as well as an enlarged liver and spleen. Hydrops Fetalis can be caused by a variety of factors, including genetic disorders, infections, and blood disorders. It is a serious condition that can lead to stillbirth or death of the fetus if not treated promptly. Treatment typically involves addressing the underlying cause of the condition and managing the symptoms.
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder that affects multiple organs and systems in the body. It is characterized by the production of autoantibodies that attack healthy cells and tissues, leading to inflammation and damage. The symptoms of SLE can vary widely and may include joint pain and swelling, skin rashes, fatigue, fever, and kidney problems. Other possible symptoms may include chest pain, shortness of breath, headaches, and memory problems. SLE can affect people of all ages and ethnicities, but it is more common in women than in men. There is no known cure for SLE, but treatment can help manage symptoms and prevent complications. Treatment may include medications to reduce inflammation, suppress the immune system, and prevent blood clots. In some cases, hospitalization may be necessary to manage severe symptoms or complications.
Arrhythmias, cardiac refer to abnormal heart rhythms that are not synchronized with the electrical signals that control the heartbeat. These abnormal rhythms can be caused by a variety of factors, including structural abnormalities of the heart, damage to the heart muscle, or problems with the electrical conduction system of the heart. Arrhythmias can range from relatively harmless to life-threatening. Some common types of cardiac arrhythmias include atrial fibrillation, ventricular tachycardia, and atrial flutter. Symptoms of arrhythmias may include palpitations, shortness of breath, dizziness, or fainting. Treatment for arrhythmias may involve medications, lifestyle changes, or medical procedures such as catheter ablation or implantation of a pacemaker or defibrillator.
Pregnancy complications refer to any medical conditions or problems that arise during pregnancy that can potentially harm the mother or the developing fetus. These complications can range from minor issues that can be easily managed to life-threatening conditions that require immediate medical attention. Some common examples of pregnancy complications include gestational diabetes, preeclampsia, placenta previa, preterm labor, and miscarriage. Other complications may include infections, such as urinary tract infections or sexually transmitted infections, as well as conditions that can affect the baby, such as congenital anomalies or birth defects. Pregnancy complications can be caused by a variety of factors, including genetics, lifestyle choices, underlying medical conditions, and environmental factors. Proper prenatal care and regular check-ups with a healthcare provider can help identify and manage pregnancy complications early on, reducing the risk of complications and improving outcomes for both the mother and the baby.
Autoimmune diseases are a group of disorders in which the immune system mistakenly attacks healthy cells and tissues in the body. In a healthy immune system, the body recognizes and attacks foreign substances, such as viruses and bacteria, to protect itself. However, in autoimmune diseases, the immune system becomes overactive and begins to attack the body's own cells and tissues. There are over 80 different types of autoimmune diseases, and they can affect various parts of the body, including the joints, skin, muscles, blood vessels, and organs such as the thyroid gland, pancreas, and liver. Some common examples of autoimmune diseases include rheumatoid arthritis, lupus, multiple sclerosis, type 1 diabetes, and inflammatory bowel disease. The exact cause of autoimmune diseases is not fully understood, but it is believed to involve a combination of genetic and environmental factors. Treatment for autoimmune diseases typically involves managing symptoms and reducing inflammation, and may include medications, lifestyle changes, and in some cases, surgery.
Cardiac catheterization is a medical procedure that involves inserting a thin, flexible tube called a catheter into a blood vessel in the groin, arm, or neck and threading it up to the heart. The catheter is then used to inject a contrast dye into the heart's chambers and blood vessels, which allows doctors to see the heart's structure and function on X-ray images. The procedure is typically used to diagnose and treat a variety of heart conditions, including coronary artery disease, heart valve problems, and heart rhythm disorders. During the procedure, doctors may also perform additional tests, such as angiography, which involves taking X-ray images of the blood vessels to look for blockages or narrowing. Cardiac catheterization is generally considered a safe and minimally invasive procedure, with a low risk of complications. However, as with any medical procedure, there are some risks, including bleeding, infection, and damage to the blood vessels or heart.
Dilated cardiomyopathy is a medical condition characterized by the enlargement and weakening of the heart muscle, specifically the ventricles, which are the lower chambers of the heart responsible for pumping blood out to the rest of the body. This enlargement causes the heart to become weakened and unable to pump blood efficiently, leading to symptoms such as shortness of breath, fatigue, and swelling in the legs and ankles. Dilated cardiomyopathy can be caused by a variety of factors, including genetics, infections, alcohol and drug abuse, and certain medications. It can also be a complication of other heart conditions, such as hypertension or coronary artery disease. Diagnosis of dilated cardiomyopathy typically involves a physical examination, electrocardiogram (ECG), echocardiogram, and other imaging tests. Treatment may include medications to improve heart function, lifestyle changes such as a heart-healthy diet and exercise, and in some cases, surgery or heart transplantation.
Myocardial infarction (MI), also known as a heart attack, is a medical condition that occurs when blood flow to a part of the heart muscle is blocked, usually by a blood clot. This lack of blood flow can cause damage to the heart muscle, which can lead to serious complications and even death if not treated promptly. The most common cause of a heart attack is atherosclerosis, a condition in which plaque builds up in the arteries that supply blood to the heart. When a plaque ruptures or becomes unstable, it can form a blood clot that blocks the flow of blood to the heart muscle. Other causes of heart attacks include coronary artery spasms, blood clots that travel to the heart from other parts of the body, and certain medical conditions such as Kawasaki disease. Symptoms of a heart attack may include chest pain or discomfort, shortness of breath, nausea or vomiting, lightheadedness or dizziness, and pain or discomfort in the arms, back, neck, jaw, or stomach. If you suspect that you or someone else is having a heart attack, it is important to call emergency services immediately. Early treatment with medications and possibly surgery can help to reduce the risk of serious complications and improve the chances of a full recovery.
Collagen diseases, also known as collagenopathies, are a group of disorders that affect the body's connective tissue, which is made up of collagen fibers. Connective tissue is found throughout the body and provides support and structure to organs, tissues, and bones. Collagen diseases are caused by mutations in genes that are responsible for producing collagen or the enzymes that are needed to break down and recycle collagen. These mutations can lead to the production of abnormal collagen fibers or a deficiency in the amount of collagen produced, which can cause the connective tissue to become weak and brittle. There are many different types of collagen diseases, including: 1. Ehlers-Danlos syndrome (EDS): A group of inherited disorders that affect the skin, joints, blood vessels, and connective tissue. 2. Marfan syndrome: An inherited disorder that affects the connective tissue in the heart, blood vessels, and skeletal system. 3. Osteogenesis imperfecta (OI): An inherited disorder that affects the production of collagen in the bones, causing them to be fragile and prone to fractures. 4. Loeys-Dietz syndrome: An inherited disorder that affects the connective tissue in the blood vessels, heart, and skeletal system. 5. Ullrich congenital muscular dystrophy: An inherited disorder that affects the connective tissue in the muscles, causing weakness and wasting. Treatment for collagen diseases depends on the specific disorder and its severity. In some cases, medications or physical therapy may be used to manage symptoms. In more severe cases, surgery may be necessary to repair or replace damaged tissue.
Arrhythmia, sinus refers to an abnormal rhythm of the heartbeat that originates from the sinoatrial (SA) node, which is the natural pacemaker of the heart. The SA node is located in the right atrium of the heart and is responsible for generating electrical impulses that stimulate the heart to contract and pump blood. Sinus arrhythmia is a type of arrhythmia that is characterized by an irregularity in the rate of the heartbeat. It is a relatively common condition that is usually harmless and does not require treatment. In some cases, sinus arrhythmia may be associated with other heart conditions or may be a side effect of certain medications. Symptoms of sinus arrhythmia may include palpitations, dizziness, lightheadedness, or shortness of breath. However, many people with sinus arrhythmia do not experience any symptoms at all. Diagnosis of sinus arrhythmia typically involves an electrocardiogram (ECG), which is a test that records the electrical activity of the heart. Treatment for sinus arrhythmia may involve lifestyle changes, such as avoiding caffeine and alcohol, getting regular exercise, and managing stress. In some cases, medication or other medical procedures may be necessary to treat sinus arrhythmia.
Betamethasone is a synthetic glucocorticoid hormone that is used in the medical field as a potent anti-inflammatory and immunosuppressive agent. It is commonly used to treat a variety of conditions, including allergic reactions, skin disorders, respiratory diseases, and autoimmune disorders. Betamethasone is available in various forms, including creams, ointments, injections, and tablets. It works by reducing inflammation and suppressing the immune system, which can help to reduce swelling, redness, and itching, as well as prevent the body from attacking healthy tissues. Betamethasone is generally considered safe and effective when used as directed, but it can cause side effects, including skin thinning, stretch marks, and increased risk of infection. It is important to follow the instructions of a healthcare provider when using betamethasone and to report any side effects that occur.
Myocarditis is an inflammation of the heart muscle (myocardium) that can be caused by a viral or bacterial infection, autoimmune disorders, or other factors. It can lead to swelling and damage to the heart muscle, which can affect its ability to pump blood effectively. Symptoms of myocarditis can include chest pain, shortness of breath, fatigue, and an irregular heartbeat. Treatment for myocarditis depends on the underlying cause and may include medications, rest, and lifestyle changes. In severe cases, hospitalization and supportive care may be necessary. Myocarditis can be a serious condition and can lead to complications such as heart failure, arrhythmias, and sudden cardiac death.
Transposition of the great vessels (TGV) is a rare congenital heart defect that occurs when the two main arteries leaving the heart are reversed in position. In a normally developing heart, the aorta arises from the left ventricle and the pulmonary artery arises from the right ventricle. In TGV, the aorta arises from the right ventricle and the pulmonary artery arises from the left ventricle. This abnormal connection between the great vessels can lead to a variety of complications, including decreased oxygenation of the body's tissues, heart failure, and arrhythmias. Treatment for TGV typically involves surgery to redirect the blood flow and correct the abnormal connection between the great vessels. The success of the surgery depends on the severity of the defect and the age of the patient at the time of surgery.
Sick Sinus Syndrome (SSS) is a condition characterized by abnormal functioning of the sinoatrial (SA) node, which is the natural pacemaker of the heart. The SA node is responsible for generating electrical impulses that initiate each heartbeat. In SSS, the SA node does not function properly, leading to an irregular heartbeat (arrhythmia). SSS can be caused by a variety of factors, including damage to the SA node or its surrounding tissue, inflammation or infection of the heart, or certain medications. Symptoms of SSS may include palpitations, dizziness, fainting, and shortness of breath. In severe cases, SSS can lead to life-threatening arrhythmias. Treatment for SSS typically involves medications to regulate the heartbeat or, in more severe cases, implantation of a pacemaker or other device to help control the heart's rhythm. In some cases, surgery may be necessary to repair or replace the damaged SA node.
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- For more in-depth clinical information, see Third-Degree Atrioventricular Block . (medscape.com)
- Michaelsson M, Jonzon A, Riesenfeld T. Isolated congenital complete atrioventricular block in adult life. (medscape.com)
- The long-term outcome of children with isolated congenital complete atrioventricular block. (medscape.com)
- Prenatal diagnosis of complete atrioventricular block associated with structural heart disease: combined experience of two tertiary care centers and review of the literature. (medscape.com)
- Emery-Dreifuss muscc gree atrioventricular block. (who.int)
- On the ECG there was atrial with a pacemaker being the typical form of flutter with 3:1 atrioventricular block. (who.int)
Patchwork Heart Block Tutorial1
- Today I'll be sharing a patchwork heart block tutorial inspired by this quilt from Blue Elephant Stitches . (canoeridgecreations.com)
Congestive heart f1
- In congestive heart failure, Amiloride Hydrochloride may be effective alone, but its principal indication is for concomitant use in patients receiving thiazides or more potent diuretic agents. (janusinfo.se)
- Your heart may beat slowly, or it may skip beats. (medlineplus.gov)
- Third-degree atrioventricular (AV) block, also referred to as third-degree heart block or complete heart block (CHB), is an abnormal heart rhythm resulting from a defect in the cardiac conduction system in which there is no conduction through the atrioventricular node (AVN), leading to complete dissociation of the atria and ventricles. (medscape.com)
- Normally, the heart beat starts in an area in the top chambers of the heart (atria). (medlineplus.gov)
- The atria are the two upper chambers in your heart. (msdmanuals.com)
- Special pacemaker cells in a part of the atria called the SA node (sinoatrial node) send out regular electrical signals to your heart muscle to make it contract. (msdmanuals.com)
- The AV node controls how signals pass from the upper chambers of your heart (atria) to the lower chambers (ventricles). (msdmanuals.com)
- Heart block occurs when these impulses fail to transit from the atria to the ventricles or there is a delay in conduction. (elitelearning.com)
- Third-degree AV block can be either congenital or acquired. (medscape.com)
- [ 10 ] The grandfather presented with phocomelia of arms, with three digits on each hand, congenital heart defect, and narrow shoulders. (medscape.com)
- His son presented with cardiac conduction disturbance with no congenital heart or skeletal defect. (medscape.com)
- Yan J, Varma SK, Malhotra A, Menahem S. Congenital complete heart block: single tertiary centre experience. (medscape.com)
- Identification and management of fetuses at risk for, or affected by, congenital heart block associated with autoantibodies to SSA (Ro), SSB (La), or an HsEg5-like autoantigen. (medscape.com)
- Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? (medscape.com)
- Anti-SSA/Ro and anti-SSB/La antibody-mediated congenital heart block. (medscape.com)
- Utility of cardiac monitoring in fetuses at risk for congenital heart block: the PR Interval and Dexamethasone Evaluation (PRIDE) prospective study. (medscape.com)
- Heart block occurs when slowing or complete block of this conduction occurs. (medscape.com)
- Heart block occurs when the electrical signal is slowed down or does not reach the bottom chambers of the heart. (medlineplus.gov)
- An AV block occurs at or near the AV node. (msdmanuals.com)
- A bundle branch block occurs in the fiber bundles of the conduction system in your ventricles. (msdmanuals.com)
Canoe Ridge Creations2
- Initial triage of patients with complete heart block consists of determining symptoms, assessing vital signs, and looking for evidence of compromised peripheral perfusion. (medscape.com)
- The symptoms may be different for first, second, and third degree heart block. (medlineplus.gov)
- Most often, you would not have any symptoms for first degree heart block. (medlineplus.gov)
- Diane Feenstra of Norton Shores, Michigan, had a close brush with death earlier this year, but thanks to a gadget she received for her birthday, she's here to tell the tale and warn other women of the lesser-known symptoms of a heart attack. (ijr.com)
- At first, Feenstra couldn't believe it, but then as she thought back on her symptoms and the fact that her older sister died of a heart attack, it started to make some sense. (ijr.com)
- Your provider may send you to a heart doctor (cardiologist) to check for or further evaluate heart block. (medlineplus.gov)
- After testing, the cardiologist told Feenstra that not only had she unknowingly suffered a recent heart attack , but she was poised to experience a "widowmaker" heart attack because her left anterior descending artery had a blockage. (ijr.com)
Structural heart disease1
- this is a novel mutation, in that it is associated with a gain-of-function mechanism and is associated with paroxysmal atrial fibrillation and no structural heart disease. (medscape.com)
- Heart palpitations -- Palpitations are when your heart feels like it is pounding, beating irregularly, or racing. (medlineplus.gov)
- You have a heart defect. (medlineplus.gov)
- On electrocardiography (ECG), complete heart block is represented by QRS complexes being conducted at their own rate and totally independent of the P waves (see the image below). (medscape.com)
- Interventions that address block weight and course height may be effective for masons. (cdc.gov)
- Just the other day I was wishing I had a good pattern for a heart quilt. (makezine.com)
- The color I wanted to pull from Quilt block 4 was blue so we decided to do stars and stripes and incorporate hubby's old uniform. (midwesternatheart.com)
- Now quilt block 5 was supposed to have a basket in it, but I wasn't feeling the basket. (midwesternatheart.com)
- So I present you with quilt block number 5. (midwesternatheart.com)
- I got to grandma's late today so we were only able to do one quilt block pattern. (midwesternatheart.com)
- You can finish your block anyway you like -- make a pillow, mini quilt, or make more blocks & make yourself a lovely Valentine's Day Quilt. (canoeridgecreations.com)
- Occasionally, first-degree AV block may be associated with other conduction disturbances, including bundle-branch block and fascicular blocks (bifascicular or trifascicular block). (medscape.com)
- Medical treatment of complete heart block is limited to patients with conduction disease in the AVN. (medscape.com)
- Knowing the molecular make-up and activity of a protein is critical to understanding heart failure because these problem-specific biochemical reactions are magnified in the disease," said senior study investigator Jennifer Van Eyk, Ph.D., a professor at the Johns Hopkins University School of Medicine and its Heart and Vascular Institute. (medindia.net)
- The Central Minnesota Heart Center at St. Cloud Hospital also known as MN Heart is a comprehensive cardiac care center dedicated to the discovery, management and control of cardiac disease in the adult population. (mnheart.com)
- AV block results from various pathologic states causing infiltration, fibrosis, or loss of connection in portions of the healthy conduction system. (medscape.com)
- The conduction system carries the pacemaker signals from the SA node to the rest of your heart. (msdmanuals.com)
- A heart block can occur in any part of the conduction system. (msdmanuals.com)
- Doctors group heart blocks based on what part of the conduction system is involved and how severe they are. (msdmanuals.com)
- In particular, the physical examination findings of patients with third-degree AV block will be notable for bradycardia, which can be severe. (medscape.com)
- At relatively higher concentrations, the effects on a developing fish heart are severe in that the heart muscle cannot do its job, or becomes deformed -- those fish will die," study co-author Nathaniel Scholz told the Los Angeles Times . (ibtimes.com)
- First-degree heart block is the mildest type and third-degree is the most severe. (medlineplus.gov)
- Most patients whose heart block is not otherwise treatable will require placement of a permanent pacemaker or an implantable cardioverter defibrillator (ICD). (medscape.com)
- If you have second- or third-degree heart block, you may need a pacemaker to help your heart beat regularly. (medlineplus.gov)
- Sometimes, if the heart block is expected to resolve in a day or so, a temporary pacemaker will be used. (medlineplus.gov)
- Instead a wire may be inserted through a vein and directed to the heart and connected to the pacemaker. (medlineplus.gov)
- Tissue sections of hearts after myocardial infarction. (mpg.de)
- The tissue was taken from the hearts of wild bluefin tuna and yellowfin tuna that have been held captive at the Tuna Research Conservation Center in Pacific Grove, Calif., and at the nearby Monterey Bay Aquarium. (ibtimes.com)
- Previous research showed this most common type of stroke, caused by a blocked blood vessel in the brain, is associated with inflammation that can further damage brain tissue. (heart.org)
- The Silver Heart Underline Block Name Necklace makes a perfect gift. (baltinesterjewelry.com)
- In addition, two extra decoration elements can be seen on this necklace: the underline and the heart. (baltinesterjewelry.com)
- This beautiful 14K 2-Heart 2-Strand Necklace was made in Italy for superior craftsmanship and quality. (aroundtheblock.com)
- This raises the possibility that exposure to environmental PAHs in many animals -- including humans -- could lead to cardiac arrhythmias and bradycardia, or slowing of the heart. (ibtimes.com)
- Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now discovered that the two micro RNA molecules miR-1 and miR-133 in the adult heart inactivate two genes that normally force cell division. (mpg.de)
- The two molecules, oncostatin M receptor and FGF receptor 1, control the division activity of heart muscle cells in the adult heart,' says Thomas Böttger, one of the lead authors of the study. (mpg.de)
- New heart muscle cells produced by cell division could disrupt this physiological process and cause the heart to become out of sync. (mpg.de)
- The purpose of this study was to determine whether one such intervention, the use of light-weight concrete blocks (LWBs), reduces physiological loads compared to standard-weight blocks (SWBs). (cdc.gov)
- If these molecules are switched off, the heart was less damaged after a heart attack in experiments with mice. (mpg.de)
- Scientists from Thomas Braun's department at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now been able to show in mice that one such mechanism involves two so-called micro-RNAs, miR-1 and miR-133a. (mpg.de)
- In their studies on genetically modified mice, the Bad Nauheim researchers also found that in animals in which miR-1/133a was switched off, the heart muscle cells coped much better with hypoxia conditions (oxygen depletion), such as those that exist after a heart attack. (mpg.de)
- A naturally occurring protein that blocks this inflammatory immune response, known as neonatal NET-inhibitory factor, or nNIF, was associated with better stroke recovery in a study conducted in mice. (heart.org)
- DALLAS, Sept. 22, 2021 - A naturally occurring protein that blocks an inflammatory immune response was associated with better stroke recovery in a study conducted in mice, according to preliminary research to be presented at the American Heart Association's Vascular Discovery: From Genes to Medicine Scientific Sessions 2021. (heart.org)
- To study the effects on stroke, the investigators blocked the formation of NETs in mice. (heart.org)
- It gives off electrical signals to make your heart beat at a regular rate and rhythm. (medlineplus.gov)
- In addition, we found that these animals developed a much smaller scar on the heart muscle after experimentally induced myocardial infarction. (mpg.de)
- First-degree AV block is a condition in which a 1:1 relationship exists between the P waves and QRS complexes, but the PR interval is longer than 200 msec. (medscape.com)
- In the Mobitz I second-degree AV block, the PR interval is prolonged until the P wave is not followed by a QRS complex. (medscape.com)
- The team showed how the enzyme, phosphodiesterase 5, or PDE5A, involved in heart failure, slows down the breakdown of another vital compound called, cyclic guanosine monophosphate (cyclic GMP), which is critical to cell growth and muscle contraction. (medindia.net)
- In the heart, normal impulse initiation begins in the sinoatrial node (SAN). (medscape.com)
- Finishing at 18" x 18", this block is scrap fabric friendly! (canoeridgecreations.com)
- Targeted drug therapies can now be developed and tested to work specifically on cysteine 181, to block the PDE5A enzyme, lower the breakdown of cyclic GMP, and potentially stall progression of heart failure and hypertrophy," she added. (medindia.net)
- The electrical signals travel to the lower chambers of the heart (ventricles). (medlineplus.gov)
- The electrical impulse may not reach the lower chambers of the heart. (medlineplus.gov)
- The electrical signal does not move to the lower chambers of the heart. (medlineplus.gov)
- The ventricles are the two lower chambers in your heart. (msdmanuals.com)
- Nigéria, en décembre 2022 et publie depuis lors des rapports mensuels. (who.int)
- The heart consists of many individual heart muscle cells that are electrically interconnected and represent a functional unit. (mpg.de)
- In a breakthrough study, scientists at Johns Hopkins have mapped out a key chemical step involved in blocking enzyme action in heart failure. (medindia.net)
- American scientists behind the phase I clinical trial of gene therapy for heart failure patients. (medindia.net)
- Scientists studied tuna heart tissues in labs and found that polyaromatic hydrocarbons (PAHs) -- a chemical found in crude oil -- can block important cellular pathways. (ibtimes.com)
- The heart and blood vessels are part of your cardiovascular system. (msdmanuals.com)
- The study was presented at the American Heart Association's annual Scientific Sessions in New Orleans. (medindia.net)
- Heart block is a problem in the electrical signals in the heart. (medlineplus.gov)
- Do an ECG test to check the electrical signals in your heart. (medlineplus.gov)
- Recommend that you may need to wear a heart monitor for 24 to 48 hours or longer to check the electrical signals in your heart. (medlineplus.gov)
- 2 ]. Cardiac involvement can present with erally held in a semiflexed position, and the heart block, frequently inclate 20c or early child typically begins walking on tiptoe [ 2 ]. (who.int)
- The heart fails to pump enough blood to the body. (medlineplus.gov)
- This unique wooden puzzle contains 10 Wooden Heart Blocks in shades of red, pink, and orange to delight children, young and old! (bellalunatoys.com)
- Stored neatly in the included heart-shaped wooden tray, each heart varies in size, shape, and thickness. (bellalunatoys.com)
- See also our Rainbow Wooden Heart Blocks . (bellalunatoys.com)
- More than pleased with these remarkable wooden blocks and their quality as well as such speedy service. (royalkraft.com)
- Buy Royal kraft Handcrafted Design Heart Brass Wooden Block at guaranteed low price and find exciting online sale deals of wooden printing blocks from vriksh timber govt. (royalkraft.com)
- The individual cells are interconnected via cell-cell contacts so that the electrical excitation conduction necessary for heart contraction can take place in a controlled manner. (mpg.de)
- What we found was that oil blocked key processes in the cardiac cells involved with linking excitation to contraction, which means that beat to beat, we slowed the heart cells down and we also decreased their contractility," Block told BBC. (ibtimes.com)
- The protein ion channels we observe in the tuna heart cells are similar to what we would find in any vertebrate heart and provide evidence as to how petroleum products may be negatively impacting cardiac function in a wide variety of animals," Block said. (ibtimes.com)
- To block NET formation, they administered a naturally occurring protein called nNIF, for neonatal NET-inhibitory factor, found in human umbilical cord blood. (heart.org)
- Traditionally, this type of AV block is divided into two main subcategories, Mobitz type I (Wenckebach) and Mobitz type II. (medscape.com)
- The treatment for heart block depends on the type of heart block you have and the cause. (medlineplus.gov)
- This repeating pattern is second degree, type I block, also called Mobitz I or Wenckebach. (elitelearning.com)
- This is a second degree, type II block, also called Mobitz II (but not Wenckebach II). (elitelearning.com)
- Your heart is a muscle that pumps blood through your body. (msdmanuals.com)
- Your heart pumps blood through your blood vessels Blood carries oxygen and nutrients. (msdmanuals.com)
- The signals must get to all your heart muscle cells at just the right time so your heart gives a good, strong beat that pumps blood properly. (msdmanuals.com)
- Overview of Abnormal Heart Rhythms Your heart is a muscle that pumps blood through your body. (msdmanuals.com)
- Heart Attack A heart attack is when blood flow to part of your heart is suddenly blocked and some of your heart muscle dies. (msdmanuals.com)
- I had difficulty breathing, a racing heart, and extremely low blood pressure. (cdc.gov)
Types of heart2
- The first, and sometimes most important, medical treatment for heart block is the withdrawal of any potentially aggravating or causative medications. (medscape.com)
- Treatment of third-degree AV block is based on the level of the block. (medscape.com)
- Traditionally, atrioventricular (AV) block can be classified into first-, second-, and third-degree block. (medscape.com)
- Thus, first-degree AV block represents delay or slowing of conduction. (medscape.com)
- Second-degree AV block exists when more P waves than QRS complexes are seen on the ECG, but a relationship between the P waves and QRS complexes still exists. (medscape.com)
- Some normal people, will have a first degree block especially at rest or when asleep. (medlineplus.gov)
- In the future, miR-1 and miR-133 could be used to specifically switch on cell division in the heart, for example to stimulate heart muscle regeneration after a heart attack. (mpg.de)
- The reason for this could be that the individual heart muscle cells are permanently and very closely connected to form a so-called electrical syncytium. (mpg.de)
- The disadvantage: if parts of the heart muscle are damaged, as is the case with a heart attack, for example, the heart lacks the self-healing powers. (mpg.de)
- It can be assumed that the suppression of cell division in heart muscle cells is regulated in various ways. (mpg.de)
- We found that miR-1/133a suppresses two receptors on heart muscle cells. (mpg.de)
- To investigate the background in more detail, the Max Planck researchers used heart muscle cells in which miR-1/133a could be temporarily inactivated by genetic engineering. (mpg.de)
- In the experiment, the heart muscle cells from miR-1/133a knockout animals showed higher viability and survival in hypoxia,' Valussi said. (mpg.de)
- In this case, the heart muscle cells lost the ability to contract due to the unchecked activity of the two receptors and the animals suffered heart failure. (mpg.de)
- point of view, the study shows that temporarily switching off miR-1/133a is an approach to enable the regeneration of a damaged heart muscle. (mpg.de)
- Biology of the Heart The heart is a hollow organ made of muscle. (msdmanuals.com)
- A visit to the local urgent care and an EKG later and the doctor gave her four baby aspirin and told her to chew them immediately, and then sent her to Meijer Heart Center. (ijr.com)
- The ability of a heart cell to beat," Barbara Block, a professor of marine sciences at Stanford University, said in a statement , "depends on its capacity to move essential ions like potassium and calcium into and out of the cells quickly. (ibtimes.com)
- Some people are born with a heart block. (msdmanuals.com)