Syndecan-1 expression has prognostic significance in head and neck carcinoma. (1/5027)

The syndecans are a family of cell-surface heparan sulphate proteoglycans that regulate cell behaviour by binding extracellular matrix molecules such as growth factors. The syndecan family has four members, of which syndecan-1 is the most studied and best characterized. We have studied the prognostic significance of syndecan-1 expression in squamous cell carcinoma (SCC) of the head and neck treated with surgery and post-operative radiotherapy. Paraffin-embedded tissue samples taken from 175 patients with primary SCC, followed up from 2 to 15 years after surgery, were studied for expression of syndecan-1 by immunohistochemistry. A low number (< or =50%, the median value) of syndecan-1-positive tumour cells was associated with low histological grade of differentiation (P<0.0001), a large primary tumour size (T1-2 vs. T3-4, P = 0.02), positive nodal status (NO vs. N1-3, P = 0.0006), and high clinical stage (stage I or II vs. III or IV, P<0.0001). Low syndecan-1 expression was also associated with unfavourable overall survival in a univariate analysis (P = 0.001). In a multivariate survival analysis, the clinical stage and syndecan-1 expression were the only independent prognostic factors. We conclude that syndecan-1 is a novel prognostic factor in SCC of the head and neck treated with surgery and post-operative radiotherapy.  (+info)

[3H]gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell line. (2/5027)

Cellular uptake of many chemotherapeutic nucleoside analogs is dependent on the activity of a family of nucleoside transport proteins located in the cell plasma membrane. In the present study, we examined the role of these transporters in the accumulation of gemcitabine by a human head and neck squamous carcinoma cell line. The uptake of [3H]gemcitibine was compared with that of [3H]uridine and [3H]formycin B in the parent cell line (HN-5a) and in a gemcitabine-resistant variant (GEM-8e). The HN-5a and GEM-8e cells were similar in their transport characteristics and expressed predominantly the es (equilibrative, inhibitor-sensitive) transporter subtype; less than 10% of the influx of [3H]formycin B or [3H]uridine was mediated by the ei (equilibrative inhibitor-resistant) system, and there was no evidence for Na+-dependent nucleoside transporters. [3H]Gemcitabine (10 microM) entered these cells via both the es and ei transporters with an initial rate of uptake similar to that seen with the use of [3H]formycin B or [3H]uridine. In addition, ATP-replete cells accumulated significantly less [3H]gemcitabine than did ATP-depleted cells, which is indicative of an active efflux mechanism for gemcitabine. These results show that gemcitabine is a substrate for both the es and ei nucleoside transporters of HN-5a and GEM-8e cells and that gemcitabine resistance of the GEM-8e cells cannot be attributed to changes in transporter activity. Further studies to define the characteristics of the putative efflux mechanism are clearly warranted because this system has the potential to significantly affect the clinical efficacy of gemcitabine.  (+info)

Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer. (3/5027)

5-Fluorouracil (5-FU) is an effective enhancer of radiation therapy (RT) in head and neck cancers. Due to rapid, predominantly hepatic metabolism by dihydropyrimidine dehydrogenase (DPD) and suggested clinical benefit from prolonged drug exposure, 5-FU is commonly given by continuous infusion. Eniluracil is a novel DPD-inactivator designed to prolong the half-life of 5-FU and provide sustained plasma concentrations of 5-FU with oral dosing. We conducted a Phase I study of the safety and efficacy of eniluracil given with oral 5-FU in patients receiving concurrent RT for recurrent or advanced squamous cell carcinomas of the head and neck. Thirteen patients with recurrent, metastatic, or high-risk (defined as an expected 2-year survival rate of <10%) head and neck cancer were enrolled and treated with concomitant chemoradiotherapy on an every-other-week schedule. Eniluracil at a fixed dose [20 mg twice a day (BID)] was given for 7 consecutive days (days 1-7). 5-FU and RT were given on 5 consecutive days (days 2-6). One patient was treated with once-daily RT (2.0 Gy fractions). The remaining patients received hyperfractionated RT (1.5-Gy fractions BID). The initial dose of 5-FU was 2.5 mg/m2 given BID. Dose escalation in patient cohorts was scheduled at 2.5-mg/m2 increments, with intrapatient dose escalation permitted. Lymphocyte DPD activity and serum 5-FU and uracil concentrations were monitored during two cycles. DPD activity was completely or nearly completely inactivated in all patients. Sustained, presumed therapeutic concentrations of 5-FU were observed at a dose of 5.0 mg/m2 given BID. Cumulative dose-limiting myelosuppression (both neutropenia and thrombocytopenia) was observed during the fourth and fifth cycles following administration of 5.0 mg/m2 5-FU BID. One patient died of neutropenic sepsis during cycle 4. Other late cycle toxicities included diarrhea, fatigue, and mucositis. Grade 3 mucositis was observed in 4 patients, but no grade 4 mucositis or grade 3 or 4 dermatitis was observed. A second patient death occurred during cycle 1 of treatment. No specific cause of death was identified. The study was subsequently discontinued. Cumulative myelosupression was the significant dose-limiting toxicity of oral 5-FU given with the DPD-inactivator eniluracil on an every-other-week schedule. Clinical radiation sensitization was not observed, based on the absence of dose-limiting mucositis and dermatitis. Alternative dosing schedules need to be examined to determine the most appropriate use of eniluracil and 5-FU as radiation enhancers.  (+info)

Clinical significance of decreased zeta chain expression in peripheral blood lymphocytes of patients with head and neck cancer. (4/5027)

Patients with squamous cell carcinoma of the head and neck (SCCHN) frequently have impaired immune responses. Alterations in T-cell receptor-associated signaling molecules in tumor-infiltrating as well as circulating lymphocytes have been reported in these patients. Using quantitative flow cytometry analysis, we have demonstrated that expression of the zeta chain is significantly decreased relative to normal controls in both CD8+ and CD4+ T cells as well as CD3- CD56+ CD16+ natural killer cells in the peripheral blood of patients with SCCHN who, as a result of previous therapies, have no evident disease. Patients with a more aggressive type of SCCHN and those who experienced a recurrence or had a second primary cancer within the last 2 years of the study had the lowest zeta chain expression. In addition, SCCHN patients showed a significantly greater spontaneous ex vivo apoptosis, as measured by a terminal deoxynucleotide transferase-mediated dUTP nick end labeling assay, in PBMCs, compared to normal controls. The observed decreased expression of zeta in T and natural killer cells coincided but did not directly correlate with significantly increased spontaneous apoptosis of lymphocytes obtained from treated patients with no evident disease. The results suggest that in patients with SCCHN, zeta chain defects and lymphocyte apoptosis are manifestations of long-lasting negative effects of tumor on the immune system.  (+info)

Expression of apoptosis-related genes in human head and neck squamous cell carcinomas undergoing p53-mediated programmed cell death. (5/5027)

Human head and neck squamous cell carcinoma (HNSCC) lines infected with a replication-defective Ad5CMV-p53 vector bearing a wild-type human p53 gene were used to examine alterations in the production of proteins implicated in regulating apoptosis. Because HNSCC lines express abundant levels of c-myc, and simultaneous expression of c-myc and p53 is known to trigger apoptosis in other cells, cooperation between these two genes was examined. Surprisingly, levels of c-myc mRNA and protein were rapidly and profoundly suppressed after infection with wild-type p53. Suppression of c-myc using antisense oligodeoxynucleotides (in the absence of p53) was sufficient to trigger apoptosis in Tu-138 cells, raising the possibility that the reduction of c-myc may be involved in at least one of the cell death pathways mediated by p53. Expression of a panel of Bcl-2 homology proteins was also examined in HNSCC lines undergoing p53-mediated apoptosis. No changes in Bcl-2, Bak, or Bcl-xS were found after p53 expression. Increased levels of the apoptosis-accelerating protein Bax were found in HNSCC lines after infection with Ad5CMV-p53. Induction of the apoptosis-inhibiting protein Bcl-xL was observed in Tu-167 cells and may account for the delayed onset of apoptosis in these cells. These studies suggest that multiple pathways may regulate apoptosis after transient overexpression of p53.  (+info)

The contribution of DNA ploidy to radiation sensitivity in human tumour cell lines. (6/5027)

The contribution of DNA ploidy to radiation sensitivity was investigated in a group of eight human tumour cell lines. As previous studies suggest, while more aneuploid tumours tend to be more radioresistant, there is no significant relationship between ploidy and radiation sensitivity (SF2). The failure to observe a significant effect of ploidy on radiation sensitivity is due to the complex and multifactorial basis of radiation sensitivity. When we determined the relationship between survival and radiation-induced chromosome aberration frequency, a measure independent of most other modifiers of sensitivity, we observed a direct relationship between ploidy and mean lethal aberration frequency. The mean lethal frequency of aberrations increased from about 1 for diploid cells to about 2 for tetraploid cells. The mean lethal frequency of aberrations was independent of DNA repair variations. These observations demonstrate that changes in DNA ploidy are an important contributor to radiation sensitivity variations in human tumour cell lines. Therefore, any battery of predictive assays should include DNA ploidy measurements.  (+info)

Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. (7/5027)

The purpose of this study was to determine whether cyclooxygenase-2 (COX-2) was overexpressed in squamous cell carcinoma of the head and neck (HNSCC). Quantitative reverse transcription-PCR, immunoblotting, and immunohistochemistry were used to assess the expression of COX-2 in head and neck tissue. Mean levels of COX-2 mRNA were increased by nearly 150-fold in HNSCC (n = 24) compared with normal oral mucosa from healthy volunteers (n = 17). Additionally, there was about a 50-fold increase in amounts of COX-2 mRNA in normal-appearing epithelium adjacent to HNSCC (n = 10) compared with normal oral mucosa from healthy volunteers. Immunoblotting demonstrated that COX-2 protein was present in six of six cases of HNSCC but was undetectable in normal oral mucosa from healthy subjects. Immunohistochemical analysis showed that COX-2 was expressed in both HNSCC and adjacent normal-appearing epithelium. Taken together, these results suggest that COX-2 may be a target for the prevention or treatment of HNSCC.  (+info)

Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35. (8/5027)

PURPOSE: The aim of this study was to define the scales and test the validity, reliability, and sensitivity of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-H&N35, a questionnaire designed to assess the quality of life of head and neck (H&N) cancer patients in conjunction with the general cancer-specific EORTC QLQ-C30. PATIENTS AND METHODS: Questionnaires were given to 500 H&N cancer patients from Norway, Sweden, and the Netherlands as part of two prospective studies. The patients completed the questionnaires before, during (Norway and Sweden only), and after treatment, yielding a total of 2070 completed questionnaires. RESULTS: The compliance rate was high, and the questionnaires were well accepted by the patients. Seven scales were constructed (pain, swallowing, senses, speech, social eating, social contact, sexuality). Scales and single items were sensitive to differences between patient subgroups with relation to site, stage, or performance status. Most scales and single items were sensitive to changes, with differences of various magnitudes according to the site in question. The internal consistency, as assessed by Cronbach's alpha coefficient, varied according to assessment point and within subsamples of patients. A low overall alpha value was found for the speech and the senses scales, but values were higher in assessments of patients with laryngeal cancer and in patients with nose, sinus, and salivary gland tumors. Scales and single items in the QLQ-H&N35 seem to be more sensitive to differences between groups and changes over time than do the scales and single items in the core questionnaire. CONCLUSION: The QLQ-H&N35, in conjunction with the QLQ-C30, provides a valuable tool for the assessment of health-related quality of life in clinical studies of H&N cancer patients before, during, and after treatment with radiotherapy, surgery, or chemotherapy.  (+info)

On World Head & Neck Cancer Day, Experts Urge People to Stay Away from Tobacco - Lawstreet JournalOn World Head & Neck Cancer Day, Experts Urge People to Stay Away from Tobacco - Lawstreet Journal
On World Head and Neck Cancer Day held on July 27, the experts urged Indian citizens to stay away from tobacco use, as its a major cause of cancer. Head and neck cancer occurs mainly in the mouth, larynx, throat or nose.. Dr. Harit Chaturvedi, cancer surgeon, Chairman Max Oncology, and Voice of Tobacco Victims (VoTV) patron said, Head & neck cancers are the biggest sources of the cancer burden in India. Nearly half of the newly diagnosed head & neck cancers die within 12 months of diagnosis. Paradoxically, two-thirds of head & neck cancers are related to known agents such as tobacco, areca nut, and alcohol.. Unfortunately, these causative agents are freely available either due to a weak policy implementation or absence of it. India witnesses 1.75 lac new cases of head and neck cancers every year. Of these 76% are males and 24% are females.. In India, tobacco chewing is more as compared to smoking. According to the Global Adult Tobacco Survey 2017, of the 28.6% of overall prevalence of ...
https://lawstreet.co/vantage-points/on-world-head-neck-cancer-day-experts-urge-people-to-stay-away-from-tobacco
Cisplatin and 5-fluorouracil as neoadjuvant chemotherapy: Predicting response in head and neck squamous cell cancer<...
TY - JOUR. T1 - Cisplatin and 5-fluorouracil as neoadjuvant chemotherapy. T2 - Predicting response in head and neck squamous cell cancer. AU - Wang, H. M.. AU - Wang, C. H.. AU - Chen, J. S.. AU - Chang, H. K.. AU - Kiu, M. C.. AU - Liaw, C. C.. AU - Ng, K. T.. AU - Lai, G. M.. PY - 1995. Y1 - 1995. N2 - In order to prospectively evaluate the efficacy, toxicity and predictive factors of response to neoadjuvant chemotherapy, a total of 120 patients with head and neck squamous cell cancer diagnosed from January 1992 to November 1993 were enrolled in this study. There were 118 male and 2 female patients, with a median age of 51 years (range 30-74 years). The primary sites were the oral cavity (77), oropharynx (15), hypopharynx (25) and larynx (3). Betel quid chewing was habitual in 91% of patients. All patients were previously untreated, and 94% had stage III or IV disease. Chemotherapy was given in two or three courses to 96 patients who were then assessed for response rate and predictive factors. ...
https://tmu.pure.elsevier.com/en/publications/cisplatin-and-5-fluorouracil-as-neoadjuvant-chemotherapy-predicti
Radiation therapy for head and neck neoplasms - کتابخانه دیجیتال دانشگاه علوم پزشکی اصفهان
Radiation therapy for head and neck neoplasms , Radiation therapy for head and neck neoplasms , کتابخانه دیجیتال دانشگاه علوم پزشکی اصفهان
http://elib.mui.ac.ir/site/catalogue/62204
Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer | Clinical Research Trial Listing ( Cancer/Tumors |...Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer | Clinical Research Trial Listing ( Cancer/Tumors |...
Clinical trial for Cancer/Tumors | Ewings Family Tumors | head and neck cancer | Head and Neck Cancer Metastatic | Head and Neck Carcinoma | Cancer (Pediatric) | Oral Neoplasm | Esophageal Cancer | Oral Cavity Cancer | Cancer Metastatic | Head and Neck Cancer Stage IV | Oral Cancer | Cancer | Head and Neck Cancer Stage III | Esophageal Diseases | Head and Neck Squamous Cell Carcinoma | Esophageal Disorders | Neoplasms , Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer
https://www.centerwatch.com/clinical-trials/listings/242873/head-and-neck-cancer-tadalafil-pembrolizumab-recurrent-or/?radius=50
Long-Lasting Responses Achieved with Keytruda® in Advanced Head and Neck Cancer - UNM Comprehensive Cancer CenterLong-Lasting Responses Achieved with Keytruda® in Advanced Head and Neck Cancer - UNM Comprehensive Cancer Center
Treatment with the immune-stimulating agent, Keytruda® (pembrolizumab), provides impressive long-term outcomes for some patients with metastatic or recurrent head and neck cancer. These results were recently presented at the 2016 annual meeting of the American Society of Clinical Oncology (ASCO).. Globally, head and neck cancer comprises the seventh most common type of cancer with an estimated 400,000-600,000 diagnoses every year. Head and neck squamous cell cancer (HNSCC) refers to head and neck cancer that originates in certain cells called squamous cells.. Metastatic or stage IV head and neck cancer refers to cancer that has spread from its site of origin to distant sites in the body. Overall survival at 5 years for patients diagnosed with metastatic head and neck cancer has remained at less than 4%, indicating a significant need in improved treatment for patients with this disease. Recurrent head and neck cancer refers to cancer that has recurred or progressed despite prior ...
http://cancer.unm.edu/2016/06/08/long-lasting-responses-achieved-with-keytruda-in-advanced-head-and-neck-cancer/
Table 2 | The Diagnostic Value of Cervical Lymph Node Metastasis in Head and Neck Squamous Carcinoma by Using Diffusion...Table 2 | The Diagnostic Value of Cervical Lymph Node Metastasis in Head and Neck Squamous Carcinoma by Using Diffusion...
Table 2: The Diagnostic Value of Cervical Lymph Node Metastasis in Head and Neck Squamous Carcinoma by Using Diffusion-Weighted Magnetic Resonance Imaging and Computed Tomography Perfusion
https://www.hindawi.com/journals/bmri/2014/260859/tab2/
One voice at a time - a head/neck cancer survivor speaks - Unconditionally HerOne voice at a time - a head/neck cancer survivor speaks - Unconditionally Her
What is head/neck cancer? It is any type of cancer that originates in the cranial sinuses, the mouth, or the throat. It does not include brain tumors or thyroid tumors. Why do we need a month of awareness for this type of cancer? Head/neck cancer (HNC) is not well known. It counts for about 3-5% of all new cancer diagnoses in the USA each year. Or, about 81,000 people each year. In the big picture of things this is considered an inconsequential number of people affected. But, the effects of the cancer and the treatment to eradicate the treatment has a most consequential impact on those 81,000 people every year.. 10 years ago I was at the height of my professional career. I was on a business trip and after a late meal felt a lump in my throat. When I photographed my throat I could see the lump was a big, ugly, red, yellow and white mass. As I was working for a CT scanner manufacturer, after my meeting next day I visited the engineering bay and asked the guys to scan my neck. I programmed the ...
http://newfocusdaily.com/one-voice-at-a-time-a-headneck-cancer-survivor-speaks/
NBI for Upper Aerodigestive Tract Cancers | Head & Neck Cancer Screening & Diagnosis - Sakra World HospitalNBI for Upper Aerodigestive Tract Cancers | Head & Neck Cancer Screening & Diagnosis - Sakra World Hospital
Read about Narrow Band Imaging (NBI), a new endoscopic, diagnostic technique for detection of Head & neck cancer in aerodigestive tract, provided at Sakra world Hospital.
https://www.sakraworldhospital.com/blogs/NBI-New-Advent-in-Screening-and-Diagnosing-Cancers-of-Upper-Aerodigestive-Tract/64
Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous...Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous...
Clinical trial for Locally Recurrent Head and Neck Squamous Cell Carcinoma | Recurrent Head and Neck Squamous Cell Carcinoma , Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma
https://www.centerwatch.com/clinical-trials/listings/222756/birinapant-and-intensity-modulated-re-irradiation-therapy-in-treating-patients-with-locally-recurrent-head-and-neck-squamous-cell-carcinoma/?&radius=50&query=ribonucleic%20acid&rnk=9
A Multidisciplinary Approach to Head and Neck Neoplasms - Thieme.de - Thieme Webshop - Gady Har-El, Terry A. Day, Cherie-Ann O....A Multidisciplinary Approach to Head and Neck Neoplasms - Thieme.de - Thieme Webshop - Gady Har-El, Terry A. Day, Cherie-Ann O....
A Multidisciplinary Approach to Head and Neck Neoplasms is a comprehensive how-to guide that addresses the medical and surgical treatment of the most common and challenging neoplasms in head and neck surgery. It takes a hands-on approach to describing the latest surgical techniques, including intraoperative navigation, robotic surgery, image guidance for sinus tumors, and endoscopic skull base procedures. This book will be the reference of choice for residents and fellows, experienced otolaryngologists, and head and neck surgeons ...
https://www.thieme.de/shop/HNO-Heilkunde/Har-El-Day-Nathan-Nguyen-Kirtane-de-Souza-A-Multidisciplinary-Approach-to-Head-9789382076056/p/000000000280290101?categoryCode=88
Evaluating the Effectiveness of Escitalopram to Prevent Depression in Head and Neck Cancer Patients Receiving Treatment - Full...Evaluating the Effectiveness of Escitalopram to Prevent Depression in Head and Neck Cancer Patients Receiving Treatment - Full...
Most types of head and neck cancer develop in the lining of cells found within many parts of the head and neck. Each year, more than 40,000 adults are diagnosed with head and neck cancer in the United States. The leading cause of this type of cancer is tobacco use. Common signs and symptoms of head and neck cancer include blood in saliva; frequent nose bleeds; and difficulty chewing, swallowing, or breathing. Effective treatments for head and neck cancer are available if the cancer is found in its early stages. However, treatment is difficult, causing many people to become depressed within 3 months of being diagnosed. Unfortunately, depression can lead to delays in treatment, impair quality of life, and decrease long-term survival. The purpose of this study is to determine whether the use of antidepressant medication initiated prior to starting treatment will prevent the onset of depression during treatment in non-depressed head and neck cancer patients. This study will also determine if ...
https://clinicaltrials.gov/ct2/show/NCT00536172
The Emerging Role of Immunotherapy in Head and Neck Squamous Cell Cancer | Gotoper.comThe Emerging Role of Immunotherapy in Head and Neck Squamous Cell Cancer | Gotoper.com
Introduction. Worldwide, more than 550,000 cases and 380,000 deaths occur annually from head and neck squamous cell carcinoma (HNSCC).1 In the United States, 63,000 patients are diagnosed annually, and about 13,000 die from the disease.2 The majority are related to tobacco and alcohol use, but the number of high-risk human papillomavirus (HPV)-associated oropharynx cancers is increasing; these are often identified in clinical trials via staining for the surrogate marker p16. Tumors that are p16-positive (+) have a more favorable prognosis and may require less intense treatment.3,4. Patients with HPV-associated cancers are significantly younger, have tumors typically in the tonsillar region or base of tongue, and tend to present with early-stage primary tumors with an increased risk of advanced nodal involvement when compared with HPV-negative (-) patients.5 HPV-associated tumors are pathologically distinct, with lymphocyte infiltration in the stroma and in tumor nests.6 Despite advances in ...
http://www.gotoper.com/publications/ajho/2017/2017june/the-emerging-role-of-immunotherapy-in-head-and-neck-squamos-cell-cancer
Neurobehavioral Outcomes and Quality of Life in Pediatric Patients With Brain or Head/Neck Tumors Receiving Proton or Photon...Neurobehavioral Outcomes and Quality of Life in Pediatric Patients With Brain or Head/Neck Tumors Receiving Proton or Photon...
Background: Neurobehavioral functions and quality of life (QoL) are the important outcome measurements after radiotherapy in patients with brain tumors and even head/neck cancers. However, few studies have focused on neurobehavioral functions and QoL after anti-cancer treatment particularly brain radiotherapy for pediatric/adolescent patients with brain tumors. This study thus aims to prospectively evaluate those functions in pediatric or adolescent patients with brain or head/neck tumors in order to provide useful information about their clinical outcomes.. Methods: A total of 72 pediatric/adolescent patients, who are diagnosed with brain tumors or head/neck cancers, were prospectively recruited. Neurobehavioral functions will be evaluated using a neuropsychological battery, which includes general cognitive functions, intelligence, memory, executive functions, information processing and emotional/behavioral expressions. The QoL will be evaluated by the health-related QoL questionnaire. All ...
https://clinicaltrials.gov/ct2/show/study?term=neuropsychological+outcomes+and+children+and+cancer&recr=Open&rank=2
Non-squamous variants of human papillomavirus-related head and neck carcinoma<...
TY - JOUR. T1 - Non-squamous variants of human papillomavirus-related head and neck carcinoma. AU - Bishop, Justin A.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Human papillomavirus (HPV) is now well established as an important causative agent in a subset of head and neck cancers. HPV-related head and neck carcinomas are important to recognize because these malignancies are associated with better survival and an improved response to therapy when compared to their HPV-negative counterparts. HPV-related head and neck cancer characteristically takes the form of a non-keratinizing squamous cell carcinoma. Widespread HPV testing of head and neck tumours, however, has revealed variants that depart from the standard HPV-related squamous cell carcinoma morphology. Most recently, examples of HPV-related carcinomas that actually lack a squamous phenotype, at least partially, have been reported. This manuscript will discuss these non-squamous variants of HPV-related head and neck carcinomas: adenosquamous ...
https://utsouthwestern.pure.elsevier.com/en/publications/non-squamous-variants-of-human-papillomavirus-related-head-and-ne
Head & Neck Cancer ENT Services in Utah - ENT Center of UtahHead & Neck Cancer ENT Services in Utah - ENT Center of Utah
The ENT Center of Utahs Head & Neck Surgeons specialize in Head & Neck Cancer. Contact the ENT Center of Utah today, with locations across the Salt Lake Valley.
https://www.entcenterutah.com/adult-care/head-neck-oncology/head-neck-oncology/
High CVD risk in patients with head, neck squamous cell cancerHigh CVD risk in patients with head, neck squamous cell cancer
(HealthDay)-Twenty-three percent of patients with head and neck squamous cell carcinoma (HNSCC) have cardiovascular disease (CVD) at diagnosis, and 24 percent have uncontrolled blood pressure, according to research published ...
https://medicalxpress.com/news/2017-02-high-cvd-patients-neck-squamous.html
Predictors of circulating INTERLEUKIN-6 levels in head and neck cancer patients | Cancers of the Head & Neck | Full TextPredictors of circulating INTERLEUKIN-6 levels in head and neck cancer patients | Cancers of the Head & Neck | Full Text
Circulating interleukin-6 (IL-6) improves outcome prediction for second primary cancer (SPC) in head and neck cancer (HNC) patients. This study aimed to identify factors associated with IL-6 serum levels in HNC patients. This study was conducted as part of a phase III chemoprevention trial. IL-6 was measured using chemiluminescent immunometric assay on pretreatment serum sample obtained from 527 stage I-II HNC patients. Patients lifestyle habits, sociodemographic, medical and tumor characteristics were evaluated before radiation therapy (RT). Factors independently associated with IL-6 levels before RT were identified using multiple linear regression. The median IL-6 serum level was 3.1 ng/L. In the multivariate analysis, eight factors were significantly associated (p | 0.05) with IL-6: age, gender, marital status, body mass index, tobacco consumption, comorbidities, Karnofsky Performance Status and HNC site. Smoking duration and lifetime pack-years were positively associated with IL-6 serum levels in
https://cancersheadneck.biomedcentral.com/articles/10.1186/s41199-018-0029-5
Journal of Head & Neck Physicians and SurgeonsJournal of Head & Neck Physicians and Surgeons
Cherubism is a rare benign (non-neoplastic) hereditary condition of childhood, which is inherited as an autosomal dominant trait and is characterized by bilateral expansion of the mandible, maxilla or both. Giving them a characteristic cherubic appearance. The treatment of cherubism is still controversial and is said that the disease regresses itself and after regressing if any asymmetry is left then the bony deformity can be corrected by decortications of bone and osseous shaving. This article reviews the recent development in the literature of cherubism ...
http://www.jhnps.org/showstats.asp?issn=2347-8128
Slide Knot Bracelet - Multiple Myeloma / Head + Neck Cancer - Cancer Canknot StoreSlide Knot Bracelet - Multiple Myeloma / Head + Neck Cancer - Cancer Canknot Store
Every cancer has a color. The color Burgundy represents Multiple Myeloma and Head + Neck Cancer. When you wear this bracelet symbolizing everything that Cancer Canknot do, we will donate 20% of your purchase price to cancer research. This bracelet comes in multiple sizes to fit your entire family. Child: fits wrists 4-
https://cancercanknot.com/products/multiple-myeloma-head-neck-cancer-slide-knot-bracelet
New treatment combination proves safe for head and neck cancer patientsNew treatment combination proves safe for head and neck cancer patients
Head and neck cancers are a group of biologically similar cancers originating from the upper aerodigestive tract, including the lip, mouth, nasal cavity, paranasal sinuses, pharynx and larynx that affect more than 45,000 individuals in the U.S. each year. Head and neck cancers are strongly associated with environmental and lifestyle risk factors, including tobacco smoking, alcohol consumption and certain strains of the sexually transmitted human papilloma virus.. Founded in 1984, the University of Pittsburgh Cancer Institute became a National Cancer Institute (NCI)-designated Comprehensive Cancer Center in six years. UPCI is the only cancer center in western Pennsylvania with this elite designation, serving the regions population of more than 6 million. Presently, UPCI receives a total of $154 million in research grants and is ranked 10th in NCI funding.. ...
http://www.innovations-report.com/html/reports/medicine-health/treatment-combination-proves-safe-head-neck-cancer-133558.html
In vitro chemosensitivity of head and neck cancer cell lines | European Journal of Medical Research | Full TextIn vitro chemosensitivity of head and neck cancer cell lines | European Journal of Medical Research | Full Text
Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. However, drug-resistance interferes with the effectiveness of chemotherapy. Preclinical testing models are needed in order to develop approaches to overcome chemoresistance. Ten human cell lines were obtained from HNSCC, including one with experimentally-induced cisplatin resistance. Inhibition of cell growth by seven chemotherapeutic agents (cisplatin, carboplatin, 5- fluorouracil, methotrexate, bleomycin, vincristin, and paclitaxel) was measured using metabolic MTT-uptake assay and correlated to clinically-achievable plasma concentrations. All drugs inhibited cell growth in a concentration-dependent manner with an IC50 comparable to that achievable in vivo. However, response curves for methotrexate were unsatisfactory and for paclitaxel, the solubilizer cremophor EL was toxic. Cross-resistance was observed between cisplatin and carboplatin. Chemosensitivity of HNSCC cell lines can be
https://eurjmedres.biomedcentral.com/articles/10.1186/2047-783X-15-8-337
High Level of Tobacco Carcinogen-Derived DNA Damage in Oral Cells Is an Independent Predictor of Oral/Head and Neck Cancer Risk...High Level of Tobacco Carcinogen-Derived DNA Damage in Oral Cells Is an Independent Predictor of Oral/Head and Neck Cancer Risk...
Exposure to tobacco-specific nitrosamines (TSNA) and polycyclic aromatic hydrocarbons (PAH) is recognized to play an important role in the development of oral/head and neck squamous cell cancer (HNSCC). We recently reported higher levels of TSNA-associated DNA adducts in the oral cells of smokers with HNSCC as compared with cancer-free smokers. In this study, we further investigated the tobacco constituent exposures in the same smokers to better understand the potential causes for the elevated oral DNA damage in smokers with HNSCC. Subjects included cigarette smokers with HNSCC (cases, n = 30) and cancer-free smokers (controls, n = 35). At recruitment, tobacco/alcohol use questionnaires were completed, and urine and oral cell samples were obtained. Analysis of urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and N-Nitrosonornicotine (NNN; TSNA biomarkers), 1-hydroxypyrene (1-HOP, a PAH), cotinine, 3′-hydroxycotinine, and the nicotine metabolite ratio (NMR) were performed. Cases ...
http://cancerpreventionresearch.aacrjournals.org/content/10/9/507?utm_source=sep17&utm_medium=carousel3&utm_campaign=170140
7219 Head & Neck Cancer: Issues Related to Speech & Swallowing | Motivations CEU7219 Head & Neck Cancer: Issues Related to Speech & Swallowing | Motivations CEU
#7219 Head and Neck Cancer: Issues Related to Speech and Swallowing The purpose of this course is to provide a knowledge base on the diagnosis of dysphagia and speech deficits and treatment strategies including use of tracheoesophageal prosthesis (TEP) for individuals diagnosed with head and neck cancers. Characteristics and functional impact of head and neck lymphedema on speech, swallowing and quality of life will be reviewed. The importance of a multi-disciplinary team approach in the treatment of head and neck cancer will also be discussed. (Introductory Level) Instructor: Catherine C. Crowley, Ph.D, CCC-SLP and Kristin Beadle, M.S., CCC-SLP, CLT Live Webinar Dates and Times:No dates scheduled at this time
https://www.motivationsceu.com/product-page/7219-head-neck-cancer-issues-related-to-speech-swallowing
Head & Neck Oncology | ArticlesHead & Neck Oncology | Articles
The official journal of the Head & Neck Optical Diagnostics Society. Head & Neck Oncology encompasses all aspects of clinical practice, basic and ...
https://headandneckoncology.biomedcentral.com/articles?tab=keyword
Machine learning improves the diagnosis of patients with head and neck cancers: Department of Anesthesiology and Operative...Machine learning improves the diagnosis of patients with head and neck cancers: Department of Anesthesiology and Operative...
Every year, more than 17,000 people in Germany are diagnosed with head and neck cancers. These include cancers of the oral cavity, larynx and nose, but can also affect other areas of the head and neck. Some head and neck cancer patients will also develop lung cancer. In the large majority of cases, it is impossible to determine whether these represent pulmonary metastases of the patients head and neck cancer or a second primary cancer, i.e. primary lung cancer, explains Prof. Dr. Frederick Klauschen of Charités Institute of Pathology, who co-led the study alongside Prof. Dr. David Capper of Charités Department of Neuropathology. This distinction is hugely important in the treatment of people affected by these cancers, emphasizes Prof. Klauschen, adding: While surgery may provide a cure in patients with localized lung cancers, patients with metastatic head and neck cancers fare significantly worse in terms of survival and will require treatments such as chemoradiotherapy ...
https://anaesthesieintensivmedizin.charite.de/en/metas/news/artikel/detail/machine_learning_improves_the_diagnosis_of_patients_with_head_and_neck_cancers/
Oral, Head and Neck Oncology and Reconstructive Surgery - 9780323265683Oral, Head and Neck Oncology and Reconstructive Surgery - 9780323265683
Oral, Head and Neck Oncology and Reconstructive Surgery is the first multidisciplinary text to provide readers with a system for managing adult head and neck cancers based upon stage. Using an evidence-based approach to the management and treatment of a wide variety of clinical conditions, the extensive experience of the author and contributors in head and neck surgery and oncology are highlighted throughout the text. This includes computer aided surgical simulation, intraoperative navigation, robotic surgery, endoscopic surgery, microvascular reconstructive surgery, molecular science, and tumor immunology. In addition, high quality photos and illustrations are included, which are easily accessible on mobile devices.
https://evolve.elsevier.com/cs/product/9780323265683?role=student
Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and...Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and...
GSH and transcription factor NF-alphaB can contribute independently to cisplatin and radiation sensitivity of human HNSCC. These results highlight the need to define molecular determinants of chemotherapy and radiation sensitivity for use in the selection of patients and as novel targets for therapy …
https://pubmed.ncbi.nlm.nih.gov/11084634/?dopt=Abstract
Official news concerning Apoptosis 2020 | PresseportalOfficial news concerning Apoptosis 2020 | Presseportal
latest releases: ✓ DEBIOPHARM LAUNCHES TRILYNX - A LARGE-SCALE PHASE III CLINICAL TRIAL TO FURTHER EVALUATE XEVINAPANT IN THE TREATMENT OF HEAD & NECK CANCER ✓ DEBIOPHARM TO PRESENT LATE BREAKING HEAD & NECK CANCER ABSTRACT AT THE 2020 EUROPEAN SOCIETY OF MEDICAL ONCOLOGY CONGRESS ✓ DEBIOPHARMS IAP ANTAGONIST SIGNIFICANTLY IMPROVES OVERALL SURVIVAL OF HIGH-RISK HEAD & NECK CANCER PATIENTS ✓ Debiopharm expands its radiopharmaceutical footprint with an exclusive in-licensing agreement of 3B Pharmaceuticals targeted CAIX radiotherapy
https://www.presseportal.de/en/st/Apoptosis
Head and neck cancer cell lines are resistant to mitochondrial-depolarization-induced apoptosis.
PURPOSE: Mitochondrial dysfunction has been linked to defects in the apoptotic pathway, and solid tumors, including head and neck squamous cell carcinoma (HNSCC), exhibit defects in apoptosis. Loss of mitochondrial membrane potential (DeltaPsim) is a
http://www.biomedsearch.com/nih/Head-neck-cancer-cell-lines/18483464.html
Head and neck cancer - WikipediaHead and neck cancer - Wikipedia
Head and neck cancer is a group of cancers that starts within the mouth, nose, throat, larynx, sinuses, or salivary glands. Symptoms may include a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in the voice. There may also be unusual bleeding, facial swelling, or trouble breathing. About 75% of head and neck cancer is due to the use of alcohol or tobacco. Other risk factors include betel quid, certain types of human papillomavirus, radiation exposure, certain workplace exposures, and Epstein-Barr virus. Head and neck cancers are most commonly of the squamous cell carcinoma type. The diagnosis is confirmed by tissue biopsy. The degree of spread may be determined by medical imaging and blood tests. Not using tobacco or alcohol can reduce the risk. While screening in the general population does not appear to be useful, screening high risk groups by examination of the throat might be useful. Often, head and neck cancer is curable if detected ...
https://en.wikipedia.org/wiki/Head_and_neck_cancer
Conference report on the Indo Global Summit on Head and Neck Oncology (IGSHNO 2017-BMCON-IV), 24-26 February 2017, Jaipur,...Conference report on the Indo Global Summit on Head and Neck Oncology (IGSHNO 2017-BMCON-IV), 24-26 February 2017, Jaipur,...
Conference report on the Indo Global Summit on Head and Neck Oncology (IGSHNO 2017-BMCON-IV), 24-26 February 2017, Jaipur, India Tej Prakash Soni,
https://ecancer.org/en/journal/article/739-conference-report-on-the-indo-global-summit-on-head-and-neck-oncology-igshno-2017-bmcon-iv-24-26-february-2017-jaipur-india
Radiotherapy Treatments for Head and Neck Cancer | Effective Health Care ProgramRadiotherapy Treatments for Head and Neck Cancer | Effective Health Care Program
Decisions about treatment for head and neck cancer are largely dependent on the site, stage, and histological characteristics of the disease. Treatment may include surgery, RT, chemotherapy, or some combination of these. RT is offered to nearly 75 percent of patients with head and neck cancer with curative or palliative intent, often with long-term side effects.. RT techniques have evolved over the past 30 years; two-dimensional images have been replaced with three-dimensional (3D) images with the intended purpose of improving effectiveness while reducing toxicity to normal tissues and adjacent vulnerable organs. Photon-based conformal external-beam RT modalities used to treat head and neck cancer include 3D conformal RT (3DCRT), intensity-modulated RT (IMRT), and stereotactic body RT (SBRT). Charged particle-based conformal external-beam RT modalities, such as proton-beam RT (PBT), are also available to treat head and neck cancer, although they are not widely available in the United ...
https://effectivehealthcare.ahrq.gov/topics/head-neck-cancer-update/clinician
Plus itPlus it
Objective: Head and Neck Squamous Cell Carcinoma (HNSCC) is the fifth most common cancer worldwide with five-year survival rate of 50% despite use of modern treatment modalities. We have employed a comprehensive genome-wide integrated analysis of epigenetic and transcriptional alteration in primary HNSCC tissues in order to discover novel biomarkers of this disease.. Experimental Design: A discovery cohort included 44 primary HNSCC and 25 normal mucosal samples was analyzed by Affymetrix GeneChip Human Exon 1.0 and Illumina Infinium Human Methylation 27 arrays. An independent validation cohort included 32 primary HNSCC and 15 normal mucosal samples to confirm differential methylation by bisulfate sequencing. A second validation cohort included salivary rinse and primary tissue from 59 HNSCC and 31 healthy patients. Detection of DNA methylation in bodily fluids and primary tissues from the later cohort was evaluated by quantitative methylation-specific PCR (qMSP).. Results: We have applied novel ...
http://cancerres.aacrjournals.org/content/73/8_Supplement/3554
Association between head and neck cancer and sexually transmitted diseases - Forskning - Region Hovedstaden
Background: An association between sexually transmitted diseases (STDs) and occurrence of head and neck cancer (HNC) is proposed.Aims/objectives: We aimed to determine the association between selected STDs (syphilis, gonorrhoea, HIV) and HNC.Materials and methods: Patients diagnosed with HNC in Denmark between 1978 and 2014 identified through the Danish Cancer Registry were included. Patients were age- and sex-matched in a 1:10 ratio with general population controls. Uni- and multivariate analyses were performed using the Cox regression model to assess the correlation between STD and HNC.Results: A total of 39,405 HNC patients (63% men; 63.0 years at HNC diagnosis) and 393,238 controls were included. STD in HNC patients was 0.27%, vs. 0.11% in controls. Patients with cancer of the upper airways had a significantly higher prevalence of an STD prior to the HNC compared to controls. Most HNC patients with a prior STD (64.1%) developed the HNC within five years after the STD diagnosis.Conclusions: ...
https://research.regionh.dk/da/publications/association-between-head-and-neck-cancer-and-sexually-transmitted-diseases
Head & Neck Cancer | Landrum ENTHead & Neck Cancer | Landrum ENT
(580) 421-6470 | Head and neck cancers are those that grow in and around the throat, larynx, nose, sinuses and mouth. The majority of these cancers are squamous cell
https://landrument.com/head-neck-surgery/head-neck-cancer/
Head & Neck - Cancers We Treat - Wilmot Cancer Institute - University of Rochester Medical CenterHead & Neck - Cancers We Treat - Wilmot Cancer Institute - University of Rochester Medical Center
The two strongest risk factors for these cancers are excessive alcohol use and tobacco use. At least 75 percent of head and neck cancers are related to alcohol and tobacco use, and people who drink excessively and use tobacco - whether smoked or chewed - are at even greater risk than those who use either tobacco or alcohol alone. ...
https://www.urmc.rochester.edu/cancer-institute/cancers/head-neck.aspx
Role of twist in head and neck carcinoma with lymph node metastasis<...
TY - JOUR. T1 - Role of twist in head and neck carcinoma with lymph node metastasis. AU - Ou, Da Liang. AU - Chien, Hsiung Fei. AU - Chen, Chi Long. AU - Lin, Tsung Chin. AU - Lin, Liang In. PY - 2008/3. Y1 - 2008/3. N2 - The transcription factor Twist protein has been found to be correlated with metastasis in various carcinomas, including hepatocellular, breast and prostate carcinomas. However, the role of Twist in head and neck squamous cell carcinomas (HNSCC) remains unknown. Head and neck cancer tissue microarrays (TMAs) of tumors from 50 patients with HNSCC were examined. Immunohistochemical (IHC) stain analysis showed that, out of the 50 patients, twenty (40%) showed Twist-positive staining in the tumor cells, and Twist expression was positively associated with differentiation status (p=0.027), lymph node metastasis (p=0.032) and disease progression (p=0.029). Further analysis revealed that the expression of Twist was positively correlated with CXCR4 (Spearman, r=0.408, p=0.003) and CCR7 ...
https://tmu.pure.elsevier.com/zh/publications/role-of-twist-in-head-and-neck-carcinoma-with-lymph-node-metastas
Head & Neck Cancers | St. George, UT | Southern Utah ENTHead & Neck Cancers | St. George, UT | Southern Utah ENT
The biggest risk factors for head and neck cancers are tobacco (both cigarettes and chewing tobacco) and alcohol, especially when used together.
https://southernutahent.com/services/throat-neck/head-neck-masses/
Molecular mechanisms of anti-tumor properties of P276-00 in head and neck squamous cell carcinoma | Journal of Translational...Molecular mechanisms of anti-tumor properties of P276-00 in head and neck squamous cell carcinoma | Journal of Translational...
Tumors of the head and neck present aggressive pathological behavior in patients due to high expression of CDK/CCND1 proteins. P276-00, a novel CDK inhibitor currently being tested in clinic, inhibits growth of several cancers in vitro and in vivo. The pre clinical activity of P276-00 in head and neck cancer and its potential mechanisms of action at molecular level are the focus of the current studies. We have investigated the anti-cancer activity of P276-00 in head and neck tumors in vitro and in vivo. Candidate gene expression profiling and cell based proteomic approaches were taken to understand the pathways affected by P276-00 treatment. It was observed that P276-00 is cytotoxic across various HNSCC cell lines with an IC50 ranging from 1.0-1.5 μmoles/L and culminated in significant cell-cycle arrest in G1/S phase followed by apoptosis. P276-00 treatment suppressed cell proliferation through inhibition of CCND1 expression, reduced phosphorylation of retinoblastoma protein and abrogative
https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-11-42/figures/4
Regulation of antigen processing machinery component expression in head and neck cancer by signal transducers and activators of...Regulation of antigen processing machinery component expression in head and neck cancer by signal transducers and activators of...
Squamous cell carcinoma of the head and neck (SCCHN) cells can escape recognition and lysis by tumor antigen (TA)-specific cytotoxic T lymphocytes (CTL) by downregulation of antigen processing machinery (APM) components, such as the transporter associated with antigen processing (TAP)-1/2 heterodimer. APM component upregulation by interferon gamma (IFN-g) restores SCCHN cell susceptibility to lysis by CTL, but the mechanism underlying TAP1/2 downregulation in SCCHN cells is not known. Because IFN-g activates signal transducer and activator of transcription (STAT)-1, we investigated phosphorylated (p)-STAT1 as a mediator of low basal TAP1/2 expression in SCCHN cells. SCCHN cells were found to express basal total STAT1 but low to undetectable levels of pSTAT1. The association of increased pSTAT1 levels and APM components likely reflects a cause-effect relationship, since STAT1 knockdown significantly reduced both IFN-g-mediated APM component expression and TA-specific CTL recognition of IFN-g ...
http://d-scholarship.pitt.edu/9792/
Meet others living with Head & Neck Cancer - Come introduce yourself | Mayo Clinic ConnectMeet others living with Head & Neck Cancer - Come introduce yourself | Mayo Clinic Connect
Welcome to the Head and Neck Cancer group. This is a welcoming, safe place where you can meet other people who are living with head and neck cancer. Lets learn from each other and share experiences from diagnosis through treatment and coping with symptoms and recovery challenges. Im Colleen, […]
https://connect.mayoclinic.org/discussion/meet-others-living-with-head-neck-cancer-come-introduce-yourself/?pg=6
Aspiration Risk Assessment Recommended for Patients with Head and Neck CancerAspiration Risk Assessment Recommended for Patients with Head and Neck Cancer
According to an article recently published in the Archives of Otolargynology - Head and Neck Surgery, patients with head and neck cancer who are undergoing chemotherapy and radiation therapy have high rates of impaired ability to swallow, causing them to suck food or liquid particles through their vocal cords (aspiration).. Head and neck cancers originate in the oral cavity (lip, mouth, and tongue), salivary glands, paranasal sinuses, and nasal cavity, pharynx (upper back part of the throat), larynx (voice box), and lymph nodes in the upper part of the neck. Worldwide, head and neck cancer is diagnosed in approximately 640,000 people annually and is responsible for approximately 350,000 deaths each year.. Chemotherapy and radiation therapy are common treatment approaches for patients with head and neck cancer. These treatments are, however, associated with side effects, some of which impair ability to swallow. When swallowing is impaired, there is a risk of aspiration, often thought of as food ...
http://cancer.unm.edu/2009/03/08/aspiration-risk-assessment-recommended-for-patients-with-head-and-neck-cancer/
Keytruda Improved Survival in Relapsed or Metastatic Head, Neck CancerKeytruda Improved Survival in Relapsed or Metastatic Head, Neck Cancer
First-line treatment with Keytruda significantly prolongs survival of patients with recurrent or metastatic head and neck squamous cell carcinoma
https://immuno-oncologynews.com/2018/10/24/keytruda-improved-survival-in-relapsed-or-metastatic-head-neck-cancer/
What is Head/Neck Cancer?
Head and neck cancer refers to tumors that occur in the lining of the nose, mouth (oral cancer) or throat, as well as cancers of the thyroid, parathyroid and salivary glands. Doctors also include advanced skin cancers of the head and neck (scalp, ears, face and neck) in this category of cancers. ...
http://www.dansvoice.org/what-is-head-neck-cancer-.html
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers. - Nuffield Department of...
Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression clustered with the expression of 10 well-known hypoxia-regulated genes (e.g., CA9, GLUT1, and VEGF). To minimize random aggregation, strongly correlated up-regulated genes appearing in |50% of clusters defined a signature comprising 99 genes, of which 27% were previously known to be hypoxia associated. The median RNA expression of the 99 genes in the signature was an independent prognostic factor for recurrence-free survival in a publicly available head and neck cancer data set, outdoing the original intrinsic classifier. In a published breast cancer series, the hypoxia signature was a significant prognostic factor for overall survival independent of clinicopathologic risk factors and a trained profile. The work highlights the validity and potential of using data from analysis of in vitro stress pathways for deriving a biological
https://www.nds.ox.ac.uk/publications/125205
Exosomes Derived from Squamous Head and Neck Cancer Promote Cell Survival after Ionizing Radiation - pdf descargar
Exosomes Derived from Squamous Head and Neck Cancer Promote Cell Survival after Ionizing Radiation. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
http://libros.duhnnae.com/2017/jun9/149855250261-Exosomes-Derived-from-Squamous-Head-and-Neck-Cancer-Promote-Cell-Survival-after-Ionizing-Radiation.php
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells<...
TY - JOUR. T1 - p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. AU - Kang, Sumin. AU - Elf, Shannon. AU - Lythgoe, Katherine. AU - Hitosugi, Taro. AU - Taunton, Jack. AU - Zhou, Wei. AU - Xiong, Li. AU - Wang, Dongsheng. AU - Muller, Susan. AU - Fan, Songqing. AU - Sun, Shi Yong. AU - Marcus, Adam I.. AU - Gu, Ting Lei. AU - Polakiewicz, Roberto D.. AU - Chen, Zhuo. AU - Khuri, Fadlo R.. AU - Shin, Dong M.. AU - Chen, Jing. PY - 2010/4/1. Y1 - 2010/4/1. N2 - Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer and frequently metastasizes to LNs. Identifying metastasis-promoting factors is of immense clinical interest, as the prognosis for patients with even a single unilateral LN metastasis is extremely poor. Here, we report that p90 ribosomal S6 kinase 2 (RSK2) promotes human HNSCC cell invasion and metastasis. We determined that RSK2 was overexpressed and activated in highly invasive HNSCC ...
https://mayoclinic.pure.elsevier.com/en/publications/p90-ribosomal-s6-kinase-2-promotes-invasion-and-metastasis-of-hum
Comparative analysis of the phase III clinical trials of anti-PD1 monotherapy in head and neck squamous cell carcinoma patients...Comparative analysis of the phase III clinical trials of anti-PD1 monotherapy in head and neck squamous cell carcinoma patients...
Two phase III clinical trials (CheckMate 141 and KEYNOTE 040) have independently demonstrated that overall survival (OS) in recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients, who have failed platinum-based therapy, can be improved with anti-PD1 monotherapy. Treatment with nivolumab or pembrolizumab in R/M HNSCC patients led to an improved OS with a hazards ratio (HR) of 0.70 (95%CI 0.51-0.96; p = 0.01) and HR of 0.80 (95%CI 0.65-0.98, p = 0.0161), respectively, as compared to standard of care (SOC) chemo monotherapy regimens (specifically, cetuximab, docetaxel, or methotrexate). The gain in OS was similar in both studies, underscoring the role of anti-PD1 drugs in R/M HNSCC patients. One of the striking discrepancies between CheckMate 141 and KEYNOTE 040 was the OS observed in the control SOC arms (6.9 months median in KEYNOTE 040 versus 5.1 months in CheckMate 141), which inadvertently set a higher threshold in the bio-statistical analysis of KEYNOTE 040 so that the
https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0578-0
Elevated activity of cyclin-dependent kinase 6 in human squamous cell carcinoma lines -- Timmermann et al. 8 (4): 361 -- Cell...
Pathology Department, Harvard Medical School, Boston, Massachusetts 02115-5701, USA. We have investigated the functional integrity of the retinoblastoma tumor suppressor pathway in five human squamous cell carcinoma lines. Elevated activity of cyclin-dependent kinase 6 (cdk6), a pRB kinase, was detected in all five squamous cell carcinoma lines. Overexpression of the cdk6 protein was detected in one of the five cell lines. The cdk6-specific inhibitor p18ink4C is expressed and associated with cdk6 in all five squamous cell carcinoma lines. In contrast, only very low levels of p16ink4A were detected in these cell lines. This may contribute to the elevated activity of cdk6 in these lines. Elevated activity of cdk6 may result in hyperphosphorylation of the retinoblastoma protein and, therefore, compromise its negative growth-regulatory activity ...
http://cgd.aacrjournals.org/cgi/content/abstract/8/4/361?ijkey=229c14cbdfd8d6715f756b0324b4c22744deb025&keytype2=tf_ipsecsha
Head and neck squamous cell carcinoma cell lines as a model system for the study of oncogene expression during tumor...Head and neck squamous cell carcinoma cell lines as a model system for the study of oncogene expression during tumor...
Semantic Scholar extracted view of Head and neck squamous cell carcinoma cell lines as a model system for the study of oncogene expression during tumor progression and metastasis. by Gary Edward Gallick et al.
https://www.semanticscholar.org/paper/Head-and-neck-squamous-cell-carcinoma-cell-lines-a-Gallick-Sacks/a8e65fae620dd8f61ffeb5a4d7cad16ee68a0aa3
Primary Head and Neck Cancer: Histopathologic Predictors of Recurrence After Neck Dissection in Patients With Lymph Node...
TY - JOUR. T1 - Primary Head and Neck Cancer. T2 - Histopathologic Predictors of Recurrence After Neck Dissection in Patients With Lymph Node Involvement. AU - Olsen, Kerry D.. AU - Caruso, Michela. AU - Foote, Robert L.. AU - Stanley, Robert J.. AU - Lewis, Jean E.. AU - Buskirk, Steven J.. AU - Frassica, Deborah A.. AU - Desanto, Lawrence W.. AU - Ofallon, W. Michael. AU - Hoverman, Verna R.. PY - 1994/12. Y1 - 1994/12. N2 - Objective: Retrospectively analyze several histopathologic variables that may predict neck recurrence after neck dissection. Design: From 1970 through 1980, 284 patients with pathologically confirmed metastatic squamous cell carcinoma underwent neck dissection and received no adjuvant therapy. Kaplan-Meier evaluation estimated a 74% 2-year neck recurrence-free rate. After adjusting for the standard covariates of age, gender, neck stage, and tumor grade, we also controlled for the time-dependent co-variates of primary recurrence, occurrence in the side of the neck not ...
https://jhu.pure.elsevier.com/en/publications/primary-head-and-neck-cancer-histopathologic-predictors-of-recurr-3
NOPR: Assessment of free radical-mediated damage in head and neck squamous cell carcinoma patients and after treatment with...NOPR: Assessment of free radical-mediated damage in head and neck squamous cell carcinoma patients and after treatment with...
Reactive oxygen species (ROS) produced as a part of cellular metabolism can interact with biological macromolecules such as DNA, proteins and lipids and interfere with their normal functions, leading to the loss of cellular viability. ROS have been implicated in many pathophysiological conditions including cancer. In the present study, the damage caused by ROS and the effect of radiation in head and neck squamous cell carcinoma (HNSCC) patients were assessed in the erythrocytes by analyzing the superoxide dismutase (SOD) and catalase (CAT) activities, and levels of total thiols (T-SH) and malondialdehyde (MDA, a marker for lipid peroxidation). Blood samples were collected before the start of treatment and after the completion of radiotherapy. Both SOD and CAT activities were decreased in untreated patients, but elevated in patients after treatment. The T-SH levels were also depleted in untreated HNSCC patients, but elevated non-significantly after radiation therapy (p>0.05). The levels of MDA ...
http://nopr.niscair.res.in/handle/123456789/8273
Recurrent squamous cell carcinoma of the skin treated successfully wit | OTTRecurrent squamous cell carcinoma of the skin treated successfully wit | OTT
Recurrent squamous cell carcinoma of the skin treated successfully with single agent cetuximab therapy Selcuk Seber,1 Aylin Gonultas,2 Ozlem Ozturk,2 Tarkan Yetisyigit1 1Department of Medical Oncology, Faculty of Medicine, Namik Kemal University, 2Pathology Department, Tekirdag State Hospital, Tekirdag, Turkey Abstract: Recurrent squamous cell carcinoma of the skin is a rare but difficult to treat condition. Frequently, the disease presents itself in elderly patients with poor performance status and bearing many comorbidities, thus the decision to administer systemic chemotherapy becomes difficult to make. In addition, current chemotherapeutic protocols response rates are far from satisfactory. Recently cetuximab, a chimeric antibody against epidermal growth factor receptor, is increasingly being reported as an alternative treatment. We therefore report this case of a recurrent squamous cell carcinoma of the skin in an elderly woman with poor performance status and who had an excellent clinical
https://www.dovepress.com/recurrent-squamous-cell-carcinoma-of-the-skin-treated-successfully-wit-peer-reviewed-article-OTT
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Does sentinel lymph node biopsy have a role in node-positive head and neck squamous carcinoma?Does sentinel lymph node biopsy have a role in node-positive head and neck squamous carcinoma?
EDKINS, O; HOFMEYR, C and FAGAN, J J. Does sentinel lymph node biopsy have a role in node-positive head and neck squamous carcinoma?. S. Afr. j. surg. [online]. 2013, vol.51, n.1, pp.22-25. ISSN 2078-5151. http://dx.doi.org/10.7196/SAJS.1357.. OBJECTIVES/HYPOTHESIS: The objective of the study was to determine whether sentinel lymph node biopsy (SLNB) can be used to reduce clinical overstaging of cervical nodes in head and neck squamous cell carcinoma (SCC) in a developing world setting. STUDY DESIGN: Sentinel and echelon lymph nodes were identified by means of a combination of lymphoscintigraphy, gamma probe and blue dye staining. They were analysed histologically and their pathological status was compared with the rest of the neck dissection specimen to determine diagnostic accuracy in patients with T1-4 N0-3 SCC of the oral cavity or oropharynx undergoing primary surgical resection and neck dissection. RESULTS: Thirty-three patients were included in the study, 13 in the node-negative (N0) and ...
http://www.scielo.org.za/scielo.php?script=sci_abstract&pid=S0038-23612013000100005&lng=en&nrm=iso&tlng=en
Head & Neck Cancer Awareness Golf-A-Thon
Fifty-two Head and Neck Cancer societies and forty-five countries have declared July 27 to be International Head and Neck Cancer Day. Head and neck cancer is the leading cause of cancer-related deaths and disability in many parts of the world. Head and neck cancers include mouth and throat cancer, thyroid, skin cancers of the head and neck and the new epidemic HPV-induced oropharynx cancers.. In support of International Head and Neck Cancer Day, The Dobleman Head and Neck Cancer Institute, will be raising awareness of these diseases by hosting a Golf-A-Thon. Our annual golf-a-thon is typically held the last week of July. Specific dates will be announced at the beginning of 2017. All proceeds from this event will be used for community-based prevention and early detection by providing free head and neck cancer screenings and education, CEU course for healthcare providers, a Creighton University IPE program for dental and medical students and research.. Golfers will play as many holes as they can, ...
http://drdobleman.com/head-and-neck-cancer-golf-a-thon/
No direct effects of erythropoietin beta on a head and neck squamous cell carcinoma cell line which is growth stimulated in...No direct effects of erythropoietin beta on a head and neck squamous cell carcinoma cell line which is growth stimulated in...
article{ef10f59d-3cc7-4e16-a487-41c4d7d41751, abstract = {Introduction. Erythropoiesis-stimulating agents (ESAs) are used in cancer therapy to reverse anaemia. It has been suggested that ESAs might improve treatment outcome by reducing tumour hypoxia, but ESAs might also increase tumour growth. In this work, the effect of recombinant human erythropoietin (rHuEpo) beta was investigated on a human head and neck squamous carcinoma cell (HNSCC) line in vitro. The cell line was previously growth stimulated in combination with surgery in a xenograft model and the investigation was initiated to see if rHuEpo directly affects the tumour cell line, alone or in combination with cell stress, or if the in vivo effect should be attributed to secondary effects. Material and methods. The cell line LU-HNSCC-7 was grown in vitro and treated with rHuEpo alone or in combination with radiation, cisplatin, hypoxia or tumour extracts. The expression of the Epo receptor (EpoR) was investigated by western blotting ...
https://lup.lub.lu.se/search/publication/1412736
H-NSCC - Head and Neck Squamous Cell Carcinoma | AcronymFinderH-NSCC - Head and Neck Squamous Cell Carcinoma | AcronymFinder
How is Head and Neck Squamous Cell Carcinoma abbreviated? H-NSCC stands for Head and Neck Squamous Cell Carcinoma. H-NSCC is defined as Head and Neck Squamous Cell Carcinoma rarely.
https://www.acronymfinder.com/Head-and-Neck-Squamous-Cell-Carcinoma-
Mutant-Allele Tumor Heterogeneity, HPV Status in Head and Neck Squamous Cell Carcinoma Patients Are Effective Markers of...Mutant-Allele Tumor Heterogeneity, HPV Status in Head and Neck Squamous Cell Carcinoma Patients Are Effective Markers of...
SCOTTSDALE, AZ--(Marketwired - February 20, 2014) - Evaluating next-generation sequencing (NGS) data and associated clinical records of head and neck squamous cell carcinoma (HNSCC) patients from several institutions, made available through The Cancer Genome Atlas (TCGA), showed that combining Mutant-Allele Tumor Heterogeneity (MATH) as a biomarker with the patients HPV...
http://www.marketwired.com/press-release/mutant-allele-tumor-heterogeneity-hpv-status-head-neck-squamous-cell-carcinoma-patients-1881101.htm
Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients.Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients.
Infection with high-risk types of human papilloma virus (HPV) is currently the best-established prognostic marker for head and neck squamous cell carcinoma (HNSCC), one of the most common and lethal human malignancies worldwide. Clinical trials have been launched to address the concept of treatment de-escalation for HPV-positive HNSCC with the final aim to reduce treatment related toxicity and debilitating long-term impacts on the quality of life. However, HPV-related tumors are mainly restricted to oropharyngeal SCC (OPSCC) and there is an urgent need to establish reliable biomarkers for all patients at high risk for treatment failure. A patient cohort (n = 295) with mainly non-OPSCC (72.9%) and a low prevalence of HPV16-related tumors (8.8%) was analyzed by MassARRAY to determine a previously established prognostic methylation score (MS). Kaplan-Meier revealed a highly significant correlation between a high MS and a favorable survival for OPSCC (P = 0.0004) and for non-OPSCC (P,0.0001), which ...
https://www.dora.dmu.ac.uk/handle/2086/14521?show=full
Expression of immune response biomarkers (PD‑L1, p16, CD3+ and CD8+ TILs) in recurrent head and neck squamous cell carcinoma...Expression of immune response biomarkers (PD‑L1, p16, CD3+ and CD8+ TILs) in recurrent head and neck squamous cell carcinoma...
The immune landscape of head and neck squamous cell carcinoma in pretreated areas remains poorly documented. We aimed to assess the tumor microenvironment for biomarkers of antitumor immune responses in tumors in previously irradiated areas compared with de novo tumors. This retrospective monocentric study analyzed 100 paraffin‑embedded surgical samples of invasive head and neck squamous cell carcinoma (oral cavity, oropharynx, larynx, hypopharynx) from patients who underwent surgery between January 2010 and November 2017. We compared the immune microenvironment in 50 de novo tumors and 50 tumors recurring within irradiated areas. We used immunohistochemistry to assess p16 status, CD3+/CD8+ tumor‑infiltrating lymphocytes (TILs), and programmed death‑ligand 1 (PD‑L1) expression on tumor and immune cells in stromal and intratumoral components. CD3+ TIL counts were significantly lower in intratumoral and stromal components (P=0.003 and P=0.020, respectively) in the irradiated area cohort; ...
https://www.spandidos-publications.com/10.3892/or.2021.7928
CCR7 and CXCR4 Expression in Primary Head and Neck Squamous Cell Carcinomas and Nodal Metastases - a Clinical and...CCR7 and CXCR4 Expression in Primary Head and Neck Squamous Cell Carcinomas and Nodal Metastases - a Clinical and...
Background: Squamous cell carcinomas (SCCs) are common head and neck malignancies demonstrating lymph node LN involvement. Recently chemokine receptor overxpression has been reported in many cancers. Of particular interest, CCR7 appears to be a strong mediator of LN metastases, while CXCR4 may mediate distant metastases. Any relations between their expression in primary HNSCCs and metastatic lymph nodes need to be clarified. Aims: To investigate CCR7 andCXCR4 expression in primary HNSCCs of all tumor sizes, clinical stages and histological grades, as well as involved lymph nodes, then make comparisons, also with control normal oral epithelium. Materials and Methods: The sample consisted of 60 formalin-fixed, paraffin-embedded specimens of primary HNSCCs, 77 others of metastasi-positive lymph nodes, and 10 of control normal oral epithelial tissues. Sections were conventionally stained with H&E and immunohistochemically with monoclonal anti-CCR7 and monoclonal anti-CXCR4 antibodies. Positive cells were
http://journal.waocp.org/article_45885.html
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications<...
TY - JOUR. T1 - Radioresistance in head and neck squamous cell carcinoma. T2 - Biological bases and therapeutic implications. AU - Perri, Francesco. AU - Pacelli, Roberto. AU - Della Vittoria Scarpati, Giuseppina. AU - Cella, Laura. AU - Giuliano, Mario. AU - Caponigro, Francesco. AU - Pepe, Stefano. PY - 2015/5/1. Y1 - 2015/5/1. N2 - Head and neck squamous cell carcinoma (HNSCC) is strongly associated with alcohol and tobacco consumption. Lately, the incidence of human papillomavirus (HPV)-related tumors has shown a significant increase, and HPV-related tumors show distinctive features if compared with the HPV-negative counterpart. Locally advanced HNSCC can be treated with concomitant chemoradiotherapy, but early recurrences sometimes occur. Relapses are often related to an intrinsic radioresistance of the tumors. Alterations in intracellular pathways, primarily involved in cell proliferation, apoptosis, and DNA repair, can lead to radioresistance. Preclinical and clinical evidence highlighted ...
https://moh-it.pure.elsevier.com/en/publications/radioresistance-in-head-and-neck-squamous-cell-carcinoma-biologic
Biology, Cytogenetics, and Sensitivity to Immunological Effector Cells of New Head and Neck Squamous Cell Carcinoma Lines |...Biology, Cytogenetics, and Sensitivity to Immunological Effector Cells of New Head and Neck Squamous Cell Carcinoma Lines |...
Twenty-one head and neck squamous cell carcinoma (HNSCC) cell lines were established from 89 fresh tumor specimens in order to study the biology of HNSCC lines, establish tumors in nude mice, and evaluate the sensitivity to immunological effector cells of these tumors in vitro and in vivo in nude mice. The lines were established from explants using differential trypsinization and culture for 2 to 20 mo. The explants were derived from 11 different sites. Three pairs of lines were derived from both the primary tumor and metastatic lymph nodes in the same patients. All cultures grew as either compact or diffuse adherent monolayers, and they had a median doubling time of 86 h (range, 33 to 531 h). DNA fingerprinting confirmed that the HNSCC lines were individual isolates. Thirteen of 14 lines tested induced tumors in athymic mice. The histology of each line growing in nude mice was similar to that of the original tumor tissue. Immunocytochemistry showed keratin production in all lines tested. ...
https://cancerres.aacrjournals.org/content/49/18/5167?ijkey=2a17062f318bb3355eead7c23cb038d19f8e8da2&keytype2=tf_ipsecsha
ABT-737 Synergizes with Chemotherapy to Kill Head and Neck Squamous Cell Carcinoma Cells via a Noxa-Mediated Pathway |...ABT-737 Synergizes with Chemotherapy to Kill Head and Neck Squamous Cell Carcinoma Cells via a Noxa-Mediated Pathway |...
Cell Lines and Reagents. UM-22A, UM-22B, and 1483 are human HNSCC cell lines (Lin et al., 2007a) and were grown in Dulbeccos modified Eagles medium (DMEM) supplemented with 10% heat-inactivated fetal bovine serum (FBS) and antibiotics. ABT-737 and A-793844 were provided by Abbott Laboratories (Abbott Park, IL), dissolved in DMSO, and stored at -80°C as 10 mM stocks. Cisplatin was obtained from the University of Pittsburgh Cancer Institute Pharmacy, and etoposide was from Sigma (St. Louis, MO). Lipofectamine 2000 reagent was obtained from Invitrogen (Carlsbad, CA), and Annexin V-fluorescein isothiocyanate apoptosis detection kits were from BD Biosciences (San Jose, CA). Anti-Bcl-2 antibody was from Dako (Glostrup, Denmark), and antibodies against Bcl-XL, Bax, Noxa, and Mcl-1 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA). Antibodies against PARP and Bak were obtained from Cell Signaling Technology (Danvers, MA), and anti-caspase-3 was from Assay Designs (Ann Arbor, MI). ...
https://molpharm.aspetjournals.org/content/75/5/1231?ijkey=abf144264e14b825c32a00e19a3ce521fbd45338&keytype2=tf_ipsecsha
Dual-specificity phosphatase-1 regulates the inflammatory milieu in head and neck squamous cell carcinoma :: MEDICA, MUSC...
Head and neck cancer accounts for approximately 6% of diagnosed malignancies in the United States, with an estimated 35,000 incidences and over 7,000 deaths every year. Head and neck squamous cell carcinoma (HNSCC) comprises the majority of head and neck cancers, with a worldwide incidence of more than 500,000 cases. Head and neck cancer patients often present in advanced stages of disease, and despite ongoing research, survival rates remain lower than other more common malignancies. Cytokines and pro-inflammatory factors have been shown to have a critical role in the various steps of malignant transformation, including tumor growth, survival, invasion, angiogenesis, and metastasis. Mitogen-activated protein kinases (MAPK), such as p38, JNK, and ERK, relay information from extracellular signals to the effectors that control these diverse cellular processes. Negative regulation of MAPK activity is provided by MAPK phosphatases that dephosphorylate MAPK proteins. The founding member of this class ...
http://digital.library.musc.edu/cdm/singleitem/collection/medica/id/747/rec/18
Head & Neck Brachytherapy | Head & Neck Cancer TreatmentsHead & Neck Brachytherapy | Head & Neck Cancer Treatments
Brachytherapy treatment solutions for head & neck cancers by Elekta. Wide array of applicators including the Rotterdam. Standalone or combination treatment.
https://www.elekta.com/brachytherapy/head-and-neck/
Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell...Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell...
The presence of metastatic disease in cervical lymph nodes of head and neck squamous cell carcinoma (HNSCC) patients is a very important determinant in therapy choice and prognosis, with great impact in overall survival. Frequently, routine lymph node staging cannot detect occult metastases and the post-surgical histologic evaluation of resected lymph nodes is not sensitive in detecting small metastatic deposits. Molecular markers based on tissue-specific microRNA expression are alternative accurate diagnostic markers. Herein, we evaluated the feasibility of using the expression of microRNAs to detect metastatic cells in formalin-fixed paraffin-embedded (FFPE) lymph nodes and in fine-needle aspiration (FNA) biopsies of HNSCC patients. An initial screening compared the expression of 667 microRNAs in a discovery set comprised by metastatic and non-metastatic lymph nodes from HNSCC patients. The most differentially expressed microRNAs were validated by qRT-PCR in two independent cohorts: i) 48 FFPE lymph
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-015-0350-3/tables/3
Pembrolizumab Plus Cetuximab Shows Antitumor Activity in Squamous Cell Head and Neck Cancer - The ASCO PostPembrolizumab Plus Cetuximab Shows Antitumor Activity in Squamous Cell Head and Neck Cancer - The ASCO Post
These data suggest that pembrolizumab plus cetuximab may have promising activity for platinum-refractory or -ineligible patients with recurrent or metastatic head and neck squamous cell carcinoma, said Assuntina G. Sacco, MD, Associate Professor of Medicine and Medical Director of Infusion Services at UC San Diego Moores Cancer Center, La Jolla, California. The safety profile was also acceptable, resulting in few treatment-related discontinuations. Ongoing and future studies of combined anti-PD-1 and EGFR inhibition are indicated.. As Dr. Sacco reported, it is well established that patients with recurrent or metastatic head and neck squamous cell carcinoma who are either platinum-refractory or -ineligible have poor survival outcomes. Although there are U.S. Food and Drug Administration-approved therapies in the second-line setting, including both checkpoint inhibitors (pembrolizumab and nivolumab) and an EGFR inhibitor (cetuximab), she added, these agents are approved only as ...
https://www.ascopost.com/issues/april-25-2020/pembrolizumab-plus-cetuximab-shows-antitumor-activity-in-squamous-cell-head-and-neck-cancer/
PRLR expression in SCCHN cell lines. (A) PRLR expressio | Open-iPRLR expression in SCCHN cell lines. (A) PRLR expressio | Open-i
PRLR expression in SCCHN cell lines. (A) PRLR expression measured by flow cytometry in PCI-6A, PCI-6B and T47D cell lines. The PCI-6A cell line shows a signific
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3101909_bjc2011131f1&req=4
Head And Neck Cancer Squamous Cell Carcinoma - Pipeline Review, H2 2014 Market Research ReportHead And Neck Cancer Squamous Cell Carcinoma - Pipeline Review, H2 2014 Market Research Report
Head And Neck Cancer Squamous Cell Carcinoma - Pipeline Review, H2 2014SummaryGlobal Markets Directs, Head And Neck Cancer Squamous Cell Carcinoma - Pipeline Review, H2 2014, provides an overview of the Head And Neck Cancer Squamous Cell Carcinomas therapeutic pipeline.This report provides comprehensive information on the therapeutic development for Head And Neck Cancer Squamous Cell Carcinoma, co
https://www.researchmoz.us/head-and-neck-cancer-squamous-cell-carcinoma-pipeline-review-h2-2014-report.html
The non-coding landscape of head and neck squamous cell carcinoma | lncRNA BlogThe non-coding landscape of head and neck squamous cell carcinoma | lncRNA Blog
Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease marked by frequent recurrence and metastasis and stagnant survival rates. To enhance molecular knowledge of HNSCC and define a non-coding RNA (ncRNA) landscape of the disease, researchers at UCSD profiled the transcriptome-wide dysregulation of long non-coding RNA (lncRNA), microRNA (miRNA), and PIWI-interacting RNA (piRNA) using RNA sequencing data from 422 HNSCC patients in The Cancer Genome Atlas (TCGA). 307non-coding transcripts differentially expressed in HNSCC were significantly correlated with patient survival, and associated with mutations in TP53, CDKN2A, CASP8, PRDM9,and FBXW7 and copy number variations in chromosomes 3, 5, 7, and 18. The researchers also observed widespread ncRNA correlation to concurrent TP53 and chromosome 3p loss, a compelling predictor of poor prognosis in HNSCCs. Three selected ncRNAs were additionally associated with tumor stage, HPV status, and other clinical characteristics, and modulation ...
http://www.lncrnablog.com/the-non-coding-landscape-of-head-and-neck-squamous-cell-carcinoma/
Cisplatin Chemoradiation Course in Locally Advanced Head and Neck Cancer - The ASCO PostCisplatin Chemoradiation Course in Locally Advanced Head and Neck Cancer - The ASCO Post
In an Indian phase III trial reported in the Journal of Clinical Oncology, Vanita Noronha, MD, of Tata Memorial Hospital, Mumbai, and colleagues found that curative-intent adjuvant chemoradiation with cisplatin at 100 mg/m2 every 3 weeks produced better locoregional control vs cisplatin at 30 mg/m2 every week in patients with locally advanced head and neck squamous cell cancer.1 Severe adverse events were more common in the every-3-week group.. Study Details. In the noninferiority trial, 300 patients with locally advanced head and neck cancer at Tata Memorial Center in Mumbai were randomized between 2013 and 2017 to receive cisplatin at 30 mg/ m2 given once a week (n = 150) vs cisplatin at 100 mg/m2 given once every 3 weeks (n = 150), both administered concurrently with curative-intent radiotherapy. Disease had to be locally advanced with no distant metastases with planned curative chemoradiation, either as adjuvant treatment for ≥ 1 high-risk feature (eg, extracapsular extension, close [≤ 5 ...
https://ascopost.com/issues/may-25-2018/cisplatin-chemoradiation-course-in-locally-advanced-head-and-neck-cancer/
JCI - p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cellsJCI - p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells
Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer and frequently metastasizes to LNs. Identifying metastasis-promoting factors is of immense clinical interest, as the prognosis for patients with even a single unilateral LN metastasis is extremely poor. Here, we report that p90 ribosomal S6 kinase 2 (RSK2) promotes human HNSCC cell invasion and metastasis. We determined that RSK2 was overexpressed and activated in highly invasive HNSCC cell lines compared with poorly invasive cell lines. Expression of RSK2 also correlated with metastatic progression in patients with HNSCC. Ectopic expression of RSK2 substantially enhanced the invasive capacity of HNSCC cells, while inhibition of RSK2 activity led to marked attenuation of invasion in vitro. Additionally, shRNA knockdown of RSK2 substantially reduced the invasive and metastatic potential of HNSCC cells in vitro and in vivo in a xenograft mouse model, respectively. Mechanistically, we determined that ...
https://www.jci.org/articles/view/40582/table/2
Treatment of advanced or recurrent squamous cell carcinoma of the uterine cervix with mitomycin-C, bleomycin, and cisplatin...Treatment of advanced or recurrent squamous cell carcinoma of the uterine cervix with mitomycin-C, bleomycin, and cisplatin...
TY - JOUR. T1 - Treatment of advanced or recurrent squamous cell carcinoma of the uterine cervix with mitomycin-C, bleomycin, and cisplatin chemotherapy. AU - Smith, Harriet O.. AU - Stringer, C. Allen. AU - Kavanagh, John J.. AU - Gershenson, D. M.. AU - Edwards, C. L.. AU - Wharton, J. T.. PY - 1993/1. Y1 - 1993/1. N2 - Fifty-nine patients with recurrent/persistent, or advanced local/metastatic squamous cell cancer of the cervix were treated with combination chemotherapy consisting of mitomycin-C, bleomycin, and cisplatin. Response to therapy and survival analysis was determined for 44 of 49 patients who had previously been treated with radiation therapy and/or surgery and for 10 patients with advanced, previously untreated disease. Seven (16%) of the 44 previously treated patients experienced either complete response (CR) or partial response (PR). The median progression-free interval for responders (CR + PR) was 14.5 months, compared with 2.6 months for the nonresponders (significant, P , ...
https://einstein.pure.elsevier.com/en/publications/treatment-of-advanced-or-recurrent-squamous-cell-carcinoma-of-the-2
Human Papilloma Virus Attributable Head and Neck Cancer in the Sudan Assessed by p16<sup>INK4A</sup> Immunostaining -Asian...Human Papilloma Virus Attributable Head and Neck Cancer in the Sudan Assessed by p16<sup>INK4A</sup> Immunostaining -Asian...
Human Papilloma Virus Attributable Head and Neck Cancer in the Sudan Assessed by p16INK4A Immunostaining Head and neck cancer;human papillomavirus;$p16^{INK4A}$;Sudan; Background: The aim of this study was to screen for human papillomavirus (HPV) infections in head and neck squamous cell carcinomas (HNSCCs) using P16 immunostaining. Materials and Methods: A retrospective study was performed on 150 samples from patients diagnosed with HNSCCs. HPV status was determined using $p16^{INK4A}$. Results: 31 of the 150 (20.7%) HNSCCs were HPV positive. Conclusions: A large proportion of HNSCCs in Sudan are associated with HPV infection. The fact that the prevalence of HPV is high among Sudanese patients with head and neck cancers (HNC) has obvious implications for vaccine therapy.
http://koreascience.or.kr/article/JAKO201212855328837.page
Melanoma and Head & Neck Cancer/Genitourinary & Gynecologic Tumors Online courseMelanoma and Head & Neck Cancer/Genitourinary & Gynecologic Tumors Online course
This Melanoma and Head & Neck Cancer/Genitourinary & Gynecologic Tumors Online course is offered multiple times in a variety of locations and training topics.
https://www.trainup.com/TrainingDetails/193644/Melanoma-and-Head-Neck-CancerGenitourinary-Gynecologic-Tumors
Anti‑tumor effects of metformin on head and neck carcinoma cell lines: A systematic reviewAnti‑tumor effects of metformin on head and neck carcinoma cell lines: A systematic review
Metformin is commonly used for treating type 2 diabetes, and may also reduce cancer risk. Previous studies have demonstrated the association between metformin use and a decreased risk of head and neck cancer. Therefore, the aim of the present systematic review was to summarize the available literature on the in vitro anti‑tumor effects of metformin on head and neck squamous cell carcinoma (HNSCC). Research studies were obtained from Cochrane Library, Embase, LILACS, MEDLINE and PubMed databases, without time or language restrictions. Only in vitro studies analyzing the effects of metformin on HNSCC cell lines were included. The authors methodically appraised all the selected studies according to the Grading of Recommendations Assessment, Development and Evaluation method to make a judgment of the evidence quality. Of the 388 identified reports, 11 studies met the inclusion criteria and were used for qualitative analysis. These studies demonstrated that metformin is important in inhibiting cell ...
https://spandidos-publications.com/ol/13/2/554/abstract
Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck...Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck...
Head and neck squamous cell carcinoma (HNSCC) represents a major health concern worldwide. We applied the matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) to analyze paired normal (N) and tumor (T) samples from head and neck squamous cell carcinoma as well as liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis in HNSCC cell lines to identify tumor-associated biomarkers. Our results showed a number of proteins found to be over-expressed in HNSCC. We identified thymosin beta-4 X-linked (TMSB4X) is one of the most significant candidate biomarkers. Higher TMSB4X expression in the tumor was found by N/T-paired HNSCC samples at both RNA and protein level. Overexpression of TMSB4X was found significantly associated with poor prognosis of overall survival (OS, P = 0.006) and recurrence-free survival (RFS, P = 0.013) in HNSCC patients. Silencing of TMSB4X expression in HNSCC cell line reduced the proliferation and invasion ability in vitro, as well ...
https://www.physiciansweekly.com/global-proteomics-based-identification-and-validation-of-thymosin-beta-4-x-linked-as-a-prognostic-marker-for-head-and-neck-squamous-cell-carcinoma/
Institute of Cancer Research Repository - The role of c-erbB receptors and ligands in head and neck squamous cell carcinoma.
The role of c-erbB receptors and ligands in head and neck squamous cell carcinoma. c-erbB receptor signalling induces pleiotropic responses and influences several biological functions involved in the pathogenesis and progression of HNSCC. Aberrant expression of multiple c-erbB receptors and ligands is frequently observed in tumour cells. EGFR appears to be a dominant factor controlling the malignant phenotype in HNSCC at least in part via regulation of molecules involved in invasive and angio-/lymphangiogenic processes. Although c-erbB-2 is an orphan receptor, the formation of heterodimer complexes appears to be an important mechanism for inter-receptor activation and synergistic signal transduction. The roles of c-erbB-3 and c-erbB-4 in HNSCC progression are less clear. However, their ability to form heterodimers with other c-erbB family members enhances proliferation and invasion in HNSCC cells. At least two major downstream signalling pathways, MAPK and PI3K, are involved in the ...
http://publications.icr.ac.uk/1022/
Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma | BMC Cancer | Full TextTbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma | BMC Cancer | Full Text
Despite advances in diagnostic and treatment strategies, head and neck squamous cell cancer (HNSCC) constitutes one of the worst cancer types in terms of prognosis. PTEN is one of the tumour suppressors whose expression and/or activity have been found to be reduced in HNSCC, with rather low rates of mutations within the PTEN gene (6-8%). We reasoned that low expression levels of PTEN might be due to a transcriptional repression governed by an oncogene. Tbx2 and Tbx3, both of which are transcriptional repressors, have been found to be amplified or over-expressed in various cancer types. Thus, we hypothesize that Tbx3 may be over expressed in HNSCC and may repress PTEN, thus leading to cancer formation and/or progression. Using immunohistochemistry and quantitative PCR (qPCR), protein and mRNA levels of PTEN and Tbx3 were identified in samples excised from cancerous and adjacent normal tissues from 33 patients who were diagnosed with HNSCC. In addition, HeLa and HEK cell lines were transfected with a Tbx3
https://0-bmccancer-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2407-12-481
Serval - Salvage surgery after concomitant chemoradiation in head and neck squamous cell carcinomas - stratification for...Serval - Salvage surgery after concomitant chemoradiation in head and neck squamous cell carcinomas - stratification for...
BACKGROUND: Salvage surgery after concomitant chemoradiation therapy (CCRT) for patients with head and neck squamous cell carcinomas (HNSCC) is challenging because of its associated morbidity/mortality and the poor prognoses of these patients. METHODS: The outcome analysis of prospectively collected data from 93 patients with HNSCC with local and/or regional shows treatment failures but without distant metastasis after CCRT. RESULTS: Thirty-eight patients underwent salvage surgery, whereas 55 underwent palliative treatment, with 2-year overall survival rates of 43.4% and 0%, respectively. Initial stage IV tumors (p = .017) and concurrent local and regional failures (p = .003) were independent predictors for decreased survival after salvage surgery. Two-year overall survival rates for patients with 2, 1, or none of these predictive factors were 0%, 49%, and 83%, respectively (p = .0005). CONCLUSION: Salvage surgery after CCRT has acceptable outcomes. Initial stage IV tumors and concurre
https://serval.unil.ch/en/notice/serval:BIB_C7626BEC7807
Cell cycle and viral and immunologic profiles of head and neck squamous cell carcinoma as predictable variables of tumor...Cell cycle and viral and immunologic profiles of head and neck squamous cell carcinoma as predictable variables of tumor...
Rittà, M., De Andrea, M., Mondini, M., Mazibrada, J., Giordano, C., Pecorari, G., Garzaro, M., Landolfo, V., Schena, M., Chiusa, L. and Landolfo, S. (2009), Cell cycle and viral and immunologic profiles of head and neck squamous cell carcinoma as predictable variables of tumor progression. Head Neck, 31: 318-327. doi: 10.1002/hed.20977 ...
http://onlinelibrary.wiley.com/doi/10.1002/hed.20977/references
Cisplatin, 5-fluorouracil, and cetuximab (PFE) with or without cilengitide in recurrent/metastatic squamous cell carcinoma of...Cisplatin, 5-fluorouracil, and cetuximab (PFE) with or without cilengitide in recurrent/metastatic squamous cell carcinoma of...
Cisplatin, 5-fluorouracil, and cetuximab (PFE) with or without cilengitide in recurrent/metastatic squamous cell carcinoma of the head and neck : results of the randomized phase I/II ADVANTAGE trial (phase II part) ...
https://repository.uantwerpen.be/link/irua/115846
HKU Scholars Hub: Cervical lymph node metastatic patterns of squamous carcinomas in the upper aerodigestive tractHKU Scholars Hub: Cervical lymph node metastatic patterns of squamous carcinomas in the upper aerodigestive tract
The radical neck dissection specimens of 384 ethnically Chinese patients with different primary squamous carcinomas in the head and neck region were studied. Over 50 per cent of the specimens showed metastatic disease at one level in the neck. For oral cavity carcinoma, the levels of metastasis frequently involved were I, II and III while for carcinoma of the oropharynx, hypopharynx and larynx, the levels were II, III and IV. Extracapsular spread was present in 112/384 of patients (29 per cent) and this increased with advancing N-stages. Based on these findings, different selective neck dissections could be used for patients harbouring different primary head and neck carcinomas with limited neck disease ...
http://hub.hku.hk/handle/10722/43508
Cigarette Smoke Induces Metabolic Reprogramming of the Tumor Stroma in Head and Neck Squamous Cell Carcinoma | Molecular Cancer...Cigarette Smoke Induces Metabolic Reprogramming of the Tumor Stroma in Head and Neck Squamous Cell Carcinoma | Molecular Cancer...
Head and neck squamous cell carcinoma (HNSCC) is comprised of metabolically linked distinct compartments. Cancer-associated fibroblasts (CAF) and nonproliferative carcinoma cells display a glycolytic metabolism, while proliferative carcinoma cells rely on mitochondrial oxidative metabolism fueled by the catabolites provided by the adjacent CAFs. Metabolic coupling between these reprogrammed compartments contributes to HNSCC aggressiveness. In this study, we examined the effects of cigarette smoke-exposed CAFs on metabolic coupling and tumor aggressiveness of HNSCC. Cigarette smoke (CS) extract was generated by dissolving cigarette smoke in growth media. Fibroblasts were cultured in CS or control media. HNSCC cells were cocultured in vitro and coinjected in vivo with CS or control fibroblasts. We found that CS induced oxidative stress, glycolytic flux and MCT4 expression, and senescence in fibroblasts. MCT4 upregulation was critical for fibroblast viability under CS conditions. The effects of CS ...
https://mcr.aacrjournals.org/content/17/9/1893?iss=9
List of cutaneous neoplasms associated with systemic syndromesList of cutaneous neoplasms associated with systemic syndromes
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... Many cutaneous neoplasms occur in the setting of systemic syndromes. List of cutaneous conditions List of contact allergens ...
https://en.wikipedia.org/wiki/List_of_cutaneous_neoplasms_associated_with_systemic_syndromes
Acinic cell carcinomaAcinic cell carcinoma
Updated: Jan 13, 2021 Diagrams by Mikael Häggström, MD Thompson LD (2016). Diagnostic Pathology: Head and Neck (2nd ed.). ... "Salivary Gland Neoplasms". Medscape. ... Head and Neck Pathology. 10 (2): 152-160. doi:10.1007/s12105- ...
https://en.wikipedia.org/wiki/Acinic_cell_carcinoma
Neuroectodermal neoplasmNeuroectodermal neoplasm
"Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas". Modern Pathology. 15 (3): 264-278. ... A neuroectodermal neoplasm is a neoplasm or tumor of the neuroectoderm. They are most commonly tumors in the central or ... They include pituitary adenoma and carcinoid tumor Group II tumors/neoplasms: nonepithelial neuroectodermal neoplasms. These ... Group I tumors/neoplasms: neuroendocrine carcinomas. These show predominantly epithelial differentiation. ...
https://en.wikipedia.org/wiki/Neuroectodermal_neoplasm
Salivary gland tumourSalivary gland tumour
Mino M, Pilch BZ, Faquin WC (December 2003). "Expression of KIT (CD117) in neoplasms of the head and neck: an ancillary marker ... "Treatment of salivary gland neoplasms with fast neutron radiotherapy". Arch. Otolaryngol. Head Neck Surg. 129 (9): 944-8. doi: ... The head, neck, mouth, and throat will be checked for signs of disease, such as lumps or anything else that seems unusual. A ... Head and neck cancer Salivary gland pathology Zaleski, Michael P.; Kalhor, Neda; Moran, Cesar A. (November 2020). "Mucous Gland ...
https://en.wikipedia.org/wiki/Salivary_gland_tumour
Carcinoma ex pleomorphic adenomaCarcinoma ex pleomorphic adenoma
Mar 2012). "Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data". Head Neck ... "Salivary Gland Neoplasms". Medscape.{{cite web}}: CS1 maint: multiple names: authors list (link) Updated: Jan 13, 2021 Diagrams ... Head Neck Pathol. 7 Suppl 1: S68-76. doi:10.1007/s12105-013-0454-z. PMC 3712089. PMID 23821206. Antony, J.; Gopalan, V.; Smith ...
https://en.wikipedia.org/wiki/Carcinoma_ex_pleomorphic_adenoma
Pleomorphic adenomaPleomorphic adenoma
Head & Neck. 39 (2): 387-391. doi:10.1002/hed.24564. PMID 27550745. S2CID 3758029. McGurk M, Thomas BL, Renehan AG (November ... "Salivary Gland Neoplasms". Medscape.{{cite web}}: CS1 maint: multiple names: authors list (link) Updated: Jan 13, 2021}} ... Otolaryngology-Head and Neck Surgery. 129 (6): 726-732. doi:10.1016/j.otohns.2003.07.009. PMID 14663442. S2CID 24528326. Steve ... Otolaryngology-Head and Neck Surgery. 133 (3): 319-322. doi:10.1016/j.otohns.2005.04.008. PMID 16143173. S2CID 38480631. Ganly ...
https://en.wikipedia.org/wiki/Pleomorphic_adenoma
Nuchal fibromaNuchal fibroma
Lester D. R. Thompson; Bruce M. Wenig (2011). Diagnostic Pathology: Head and Neck: Published by Amirsys. Hagerstown, MD: ... ISBN 978-1-931884-61-7. (Articles with short description, Short description matches Wikidata, Benign neoplasms). ... The mass is usually in the neck (hence the name "nuchal-type"), but it can be seen in the extremities, lumbosacral area, ... The most common site is the posterior neck, but may also be seen in other sites (extremities, lumbosacral area, buttocks, face ...
https://en.wikipedia.org/wiki/Nuchal_fibroma
Ceruminous adenomaCeruminous adenoma
Lester D. R. Thompson; Bruce M. Wenig (2011). Diagnostic Pathology: Head and Neck: Published by Amirsys. Hagerstown, MD: ... A ceruminous adenoma is a benign glandular neoplasm which arises from the ceruminous glands located within the external ... Head Neck Pathol. 3 (1): 1-17. doi:10.1007/s12105-008-0095-9. PMC 2807538. PMID 20596983. Torske KR, Thompson LD (May 2002). " ... Durko T, Danilewicz M, Pajor A (2003). "[Glandular neoplasms of the external auditory canal--clinical and morphologic ...
https://en.wikipedia.org/wiki/Ceruminous_adenoma
MelanomaMelanoma
Mills SE (March 2002). "Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas". Modern ... Melanoma is a type of neuroectodermal neoplasm. There are four main types of melanoma: Other histopathologic types are: Mucosal ... denoting a tissue mass and especially a neoplasm), in turn from Greek μέλας melas, "dark", and -ωμα oma, "process". The word ...
https://en.wikipedia.org/wiki/Melanoma
ParotidectomyParotidectomy
... of all head and neck cancers. The root of the word parotidectomy, parotid, refers to the parotid gland meaning "situated near ... Typically performed if neoplasm is affecting deep part of parotid gland. Surgeon tries to remove the gland apart from the ... Benign parotid gland neoplasms typically present after the age of 40 and have an equal presentation in both genders. Malignant ... Neoplasms can be benign (non-cancerous) or malignant (cancerous). The majority of parotid gland tumors are benign, however 20% ...
https://en.wikipedia.org/wiki/Parotidectomy
Low-grade myofibroblastic sarcomaLow-grade myofibroblastic sarcoma
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... Overall, 51.5% of their tumors were in the head and neck areas (most commonly the tongue, followed by the larynx, gums, ...
https://en.wikipedia.org/wiki/Low-grade_myofibroblastic_sarcoma
Giant-cell fibroblastomaGiant-cell fibroblastoma
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... the head and neck areas. As defined by microscopic histopathology analyses, GCF tumors consist of a few spindle- and/or ...
https://en.wikipedia.org/wiki/Giant-cell_fibroblastoma
PDGFBPDGFB
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ...
https://en.wikipedia.org/wiki/PDGFB
Fibroblastic and myofibroblastic tumorsFibroblastic and myofibroblastic tumors
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... Connective and soft tissue neoplasms, Benign neoplasms, Cancer). ... FMTs are a heterogeneous group of soft tissue neoplasms (i.e. ... Clarke LE (October 2012). "Fibrous and fibrohistiocytic neoplasms: an update". Dermatologic Clinics. 30 (4): 643-56, vi. doi: ... in the deep subcutaneous tissue at pressure points or bone prominences but more recently has been found to be a benign neoplasm ...
https://en.wikipedia.org/wiki/Fibroblastic_and_myofibroblastic_tumors
Familial adenomatous polyposisFamilial adenomatous polyposis
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ...
https://en.wikipedia.org/wiki/Familial_adenomatous_polyposis
Gardner fibromaGardner fibroma
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... head, neck, extremities, or abdominal regions. In one study, the tumors ranged form 0.3 to 12 cm in greatest dimension (mean: ... Chokoeva AA, Patterson JW, Tchernev G (December 2017). "Giant Subcutaneous Solitary Gardner Fibroma of the Head of a Bulgarian ... Connective and soft tissue neoplasms, Benign neoplasms). ...
https://en.wikipedia.org/wiki/Gardner_fibroma
Microcystic adnexal carcinomaMicrocystic adnexal carcinoma
It usually occurs in the neck or head, although cases have been documented in other areas of the body. Most diagnosis occur ... Articles with short description, Short description matches Wikidata, Epidermal nevi, neoplasms, and cysts). ... Head & Neck. 34 (7): 1045-1050. doi:10.1002/hed.21690. PMID 21384456. S2CID 205857529. Retrieved 4 December 2020. ( ... MACs usually present as a smooth, flesh or yellow colored, slow-growing nodule or bump somewhere on the face or neck with ...
https://en.wikipedia.org/wiki/Microcystic_adnexal_carcinoma
Gardners syndromeGardner's syndrome
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... The incidence of mammary desmoid tumors is less than 0.2% of primary breast neoplasms. In Gardner's syndrome, the incidence ... List of cutaneous conditions List of dental abnormalities associated with cutaneous conditions List of cutaneous neoplasms ...
https://en.wikipedia.org/wiki/Gardner's_syndrome
Lethal midline granulomaLethal midline granuloma
Keat Jin Lee (2003). Essential otolaryngology: head & neck surgery. McGraw-Hill Professional. p. 1052. ISBN 978-0-07-137322-7. ... Matutes E (May 2018). "The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms". International Journal of ... Otolaryngology-Head and Neck Surgery. 114 (4): 653-6. doi:10.1016/s0194-5998(96)70264-4. PMID 8643282. ...
https://en.wikipedia.org/wiki/Lethal_midline_granuloma
RhabdomyoblastRhabdomyoblast
December 2015). "Rhabdomyoblastic Differentiation in Head and Neck Malignancies Other Than Rhabdomyosarcoma". Head and Neck ... Neoplasia, the formation of a neoplasm, can result in the expression of tumors and ultimately progress into cancers. The ... Rhabdomyoblastic differentiation has been detected in several other malignancies associated with the head and neck area. ... Pleuropulmonary blastoma development occurs in children; its presentation can occur via pulmonary or pleural based neoplasms. ...
https://en.wikipedia.org/wiki/Rhabdomyoblast
Ectopic salivary gland tissueEctopic salivary gland tissue
Stafne defect Barnes L (2008). Surgical pathology of the head and neck (3rd ed.). New York: Informa Healthcare. pp. 477-478. ... Salivary gland neoplasm occurrence within heterotopic salivary gland tissue is rare. ...
https://en.wikipedia.org/wiki/Ectopic_salivary_gland_tissue
ReticulohistiocytomaReticulohistiocytoma
Affected regions include the head and neck region and the upper part of the trunk. It may coexist with certain neoplasms or ...
https://en.wikipedia.org/wiki/Reticulohistiocytoma
Smile surgerySmile surgery
Some head and neck tumours invade or compress the facial nerve leading to facial paresis or paralysis. Examples of such tumours ... are facial neuromas, cholesteatomas, hemangiomas, acoustic neuromas, parotid gland neoplasms or metastases. Sometimes, the ... Tate JR, Tollefson TT (August 2006). "Advances in facial reanimation". Curr Opin Otolaryngol Head Neck Surg. 14 (4): 242-8. doi ... Otolaryngol Head Neck Surg. 141 (1): 139-41. doi:10.1016/j.otohns.2009.03.005. PMID 19559974. S2CID 21895398. Faria JC, Scopel ...
https://en.wikipedia.org/wiki/Smile_surgery
Intraneural perineuriomaIntraneural perineurioma
Kum YS, Kim JK, Cho CH, Kim HK (2009). "Intraneural reticular perineurioma of the hypoglossal nerve". Head Neck. 31 (6): 833-7 ... A clonal neoplasm associated with abnormalities of chromosome 22". Am J Clin Pathol. 103 (6): 696-704. doi:10.1093/ajcp/103.6. ... a distinctive and underrecognized peripheral nerve sheath neoplasm". Archives of Pathology & Laboratory Medicine. 131 (4): 625- ...
https://en.wikipedia.org/wiki/Intraneural_perineurioma
NeoplasmNeoplasm
These epigenetic defects occurred in various cancers (e.g. breast, ovarian, colorectal and head and neck). Two or three ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... Tawfik HM, El-Maqsoud NM, Hak BH, El-Sherbiny YM (2011). "Head and neck squamous cell carcinoma: mismatch repair ... The term neoplasm is a synonym of tumor. Neoplasia denotes the process of the formation of neoplasms/tumors, and the process is ...
https://en.wikipedia.org/wiki/Neoplasm
FibrofolliculomaFibrofolliculoma
... s are 2 to 4 mm in diameter, dome-shaped, yellowish or skin-colored papules usually located on the head, neck, ... ISBN 0-7216-2921-0. v t e (Epidermal nevi, neoplasms, and cysts, All stub articles, Epidermal nevi, neoplasm, cyst stubs). ... They are characteristically seen in Birt-Hogg-Dubé syndrome.: 674 List of cutaneous conditions List of cutaneous neoplasms ...
https://en.wikipedia.org/wiki/Fibrofolliculoma
Mucinous neoplasmMucinous neoplasm
... usually located on the head and neck.: 669 Mucinous carcinoma of the breast: Gross pathology (upper left) of mucinous carcinoma ... A mucinous neoplasm (also called colloid neoplasm) is an abnormal and excessive growth of tissue (neoplasia) with associated ... neoplasms, and cysts, All stub articles, Oncology stubs, Epidermal nevi, neoplasm, cyst stubs). ... A malignant mucinous neoplasm is called a mucinous carcinoma. For example, for ovarian mucinous tumors, approximately 75% are ...
https://en.wikipedia.org/wiki/Mucinous_neoplasm
Blastic plasmacytoid dendritic cell neoplasmBlastic plasmacytoid dendritic cell neoplasm
In one large study, this presentation was accompanied by swollen lymph nodes, usually in the neck, due to malignant pDC ... and/or ulcers that most often occur on the head, face, and upper torso. The lesions are due to diffuse infiltrations of the ... The neoplasm occurs in individuals of all ages but predominates in the elderly; in children, it afflicts males and females ... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy. It was initially regarded as a form of ...
https://en.wikipedia.org/wiki/Blastic_plasmacytoid_dendritic_cell_neoplasm
Secretory carcinomaSecretory carcinoma
Head and Neck Pathology. 15 (1): 212-224. doi:10.1007/s12105-020-01193-5. PMC 8010008. PMID 32562215. Gong P, Xia C, Yang Y, ... is a slow growing salivary gland neoplasm (the SG in MASCSG stands for salivary gland) that develops in adults and, in a ... Head & Neck. 39 (6): 1243-1248. doi:10.1002/hed.24755. PMID 28370824. S2CID 3073024. Skálová A, Vanecek T, Sima R, Laco J, ... Head and Neck Pathology. 13 (4): 562-572. doi:10.1007/s12105-018-0995-2. PMC 6854196. PMID 30564997. Baneckova M, Agaimy A, ...
https://en.wikipedia.org/wiki/Secretory_carcinoma
ParagangliomaParaganglioma
A paraganglioma is a rare neuroendocrine neoplasm that may develop at various body sites (including the head, neck, thorax and ... Head and neck paraganglioma (HNPGL): There are various types of head and neck paraganglioma; they may have specialized names ... Vagal paraganglioma: These are the least common of the head and neck paragangliomas. They usually present as a painless neck ... Is the most common of the head and neck paragangliomas. It usually presents as a painless neck mass, but larger tumors may ...
https://en.wikipedia.org/wiki/Paraganglioma
List of diseases (C)List of diseases (C)
... squamous cell of head and neck Carcinophobia Cardiac amyloidosis Cardiac and laterality defects Cardiac arrest Cardiac ... Carrington syndrome Cartilage hair hypoplasia like syndrome Cartilage-hair hypoplasia Cartilaginous neoplasms Cartwright-Nelson ... hypoxia Cerebral malformations hypertrichosis claw hands Cerebral palsy Cerebral thrombosis Cerebral ventricle neoplasms ... Choriocarcinoma Chorioretinitis Chorioretinopathy dominant form microcephaly Choroid plexus cyst Choroid plexus neoplasms ...
https://en.wikipedia.org/wiki/List_of_diseases_(C)
David DahlinDavid Dahlin
Head & Neck Surgery. 10 (3): 212-213. doi:10.1002/hed.2890100315. ISSN 1930-2398. Unni KK: David C. Dahlin [obituary]. Skeletal ... but began to develop special expertise in neoplasms of the skeletal system. No one had previously studied such lesions ... He served as section-head of surgical pathology at Mayo for many years, and was a Professor in the Mayo Medical School. Dahlin ...
https://en.wikipedia.org/wiki/David_Dahlin
Infratemporal fossaInfratemporal fossa
Rea, Paul (2016). "2 - Head". Essential Clinically Applied Anatomy of the Peripheral Nervous System in the Head and Neck. ... Certain neoplasms can spread into the infratemporal fossa. This can be surgically removed through the middle cranial fossa. The ...
https://en.wikipedia.org/wiki/Infratemporal_fossa
P16P16
... gene expression in head and neck cancer". Head & Neck. 34 (10): 1470-5. doi:10.1002/hed.21949. PMID 22106032. S2CID 11512476. ... However, p16 can be expressed in other neoplasms and in several normal human tissues. More than a third of urinary bladder SCCs ... 2017). "Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual". CA ... Dreyer JH, Hauck F, Oliveira-Silva M, Barros MH, Niedobitek G (April 2013). "Detection of HPV infection in head and neck ...
https://en.wikipedia.org/wiki/P16
Prostate cancerProstate cancer
"Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... Inferiorly, the prostate's apex heads in the direction of the urogenital diaphragm, which is pointed anterio-inferiorly. The ... central space contains the superior portion of the prostate including the most proximal aspects of the urethra and bladder neck ...
https://en.wikipedia.org/wiki/Prostate_cancer
Mir-708 microRNA precursor familyMir-708 microRNA precursor family
Head & Neck. 35 (5): 720-8. doi:10.1002/hed.23011. PMID 22605671. S2CID 5338958. Saini S, Majid S, Shahryari V, Arora S, ... "miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets ...
https://en.wikipedia.org/wiki/Mir-708_microRNA_precursor_family
CancerCancer
For certain types of cancer, such as early head and neck cancer, it may be used alone. For painful bone metastasis, it has been ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... It also causes cancer in the larynx, head, neck, stomach, bladder, kidney, esophagus and pancreas. Tobacco smoke contains over ...
https://en.wikipedia.org/wiki/Cancer
Intention tremorIntention tremor
This disease affects the proximal muscles of the head, shoulders, and neck. Tremors of this disease occur at frequencies of 2-4 ... Focal lesions such as neoplasms, tumors, hemorrhages, demyelination, or other damage may be causing dysfunction of the ... to-and-fro movements of the neck and trunk). A postural tremor may also accompany intention tremors. It is very difficult to ...
https://en.wikipedia.org/wiki/Intention_tremor
H19 (gene)H19 (gene)
... head and neck carcinomas, endometrial cancer, breast cancer, acute T cell leukemia/lymphoma, Wilms' tumor, testicular germ cell ... In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... "Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinoma". Oncogene. 18 (50): 7063-7069. doi: ... adrenocortical neoplasms, choriocarcinomas, hepatocellular carcinomas, bladder cancers, ovarian serous epithelial cancers, ...
https://en.wikipedia.org/wiki/H19_(gene)
Fibromatosis colliFibromatosis colli
... flattened head, loss of neck mobility, and scoliosis. About 95% of infants with minimal limitations in their head's mobility ... Connective and soft tissue neoplasms, Benign neoplasms). ... asymmetrical head or neck position commonly called wry neck. ... Bansal AG, Oudsema R, Masseaux JA, Rosenberg HK (2018). "US of Pediatric Superficial Masses of the Head and Neck". ... Untreated FMC tumors may also progress to facial asymmetry, plagiocephaly (i.e. flattened head), permanent loss of neck ...
https://en.wikipedia.org/wiki/Fibromatosis_colli
Downregulation and upregulationDownregulation and upregulation
... of head and neck cancers and in 42% of non-small-cell lung cancers. Epigenetic upregulation of the DNA repair genes PARP1 and ... Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms).[verification needed] Investigation ...
https://en.wikipedia.org/wiki/Downregulation_and_upregulation
CYLD cutaneous syndromeCYLD cutaneous syndrome
... gene and head and neck tumorigenesis". Cancers of the Head & Neck. 1: 10. doi:10.1186/s41199-016-0012-y. PMC 6460526. PMID ... Articles with short description, Short description is different from Wikidata, Epidermal nevi, neoplasms, and cysts, Conditions ... "CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus-Associated Head and Neck Cancers". Molecular ... Trichofolliculoma Spiradenoma spiradenocarcinoma List of cutaneous conditions List of cutaneous neoplasms associated with ...
https://en.wikipedia.org/wiki/CYLD_cutaneous_syndrome
Radiation therapyRadiation therapy
... or with radiation therapy to certain nausea-producing structures in the head during treatment of certain head and neck tumors, ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... Mouth, throat and stomach sores If the head and neck area is treated, temporary soreness and ulceration commonly occur in the ... Bertelsen A, Hansen CR, Johansen J, Brink C (May 2010). "Single Arc Volumetric Modulated Arc Therapy of head and neck cancer". ...
https://en.wikipedia.org/wiki/Radiation_therapy
List of skin conditionsList of skin conditions
Sand M, Sand D, Thrandorf C, Paech V, Altmeyer P, Bechara FG (2010). "Cutaneous lesions of the nose". Head Face Med. 6: 7. doi: ... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... Cavernous venous malformation Congenital cartilaginous rest of the neck (cervical accessory tragus, wattle) Congenital erosive ... head, legs), symptoms (pruritus, pain), duration (acute or chronic), arrangement (solitary, generalized, annular, linear), ...
https://en.wikipedia.org/wiki/List_of_skin_conditions
Ceruminous adenocarcinomaCeruminous adenocarcinoma
Lester D. R. Thompson; Bruce M. Wenig (2011). Diagnostic Pathology: Head and Neck: Published by Amirsys. Hagerstown, MD: ... This is a very rare neoplasm accounting for approximately 0.0003% of all tumors and about 2.5% of all external ear neoplasms. ... Head and Neck Pathology. 3 (1): 1-17. doi:10.1007/s12105-008-0095-9. PMC 2807538. PMID 20596983. Hicks, G. W. (1983). "Tumors ... Ceruminous adenocarcinoma is a malignant neoplasm derived from ceruminous glands of the external auditory canal. This tumor is ...
https://en.wikipedia.org/wiki/Ceruminous_adenocarcinoma
Siamese catSiamese cat
... and positioned more toward the side of the head. The breed has a long neck, a slender tail, and fur that is short, glossy, fine ... The majority of deaths were caused by neoplasms, mainly mammary tumors. The Siamese also has a higher rate of morbidity. They ... Seal point Siamese kittens Seal tabby silver Siamese Lilac point Siamese cat Side view of the head of a chocolate point adult ... The modern Siamese shares the pointed colour pattern with the Thai, or traditional Siamese, but they differ in head and body ...
https://en.wikipedia.org/wiki/Siamese_cat
Mucoepidermoid carcinomaMucoepidermoid carcinoma
Head and Neck Pathology. 7 (2): 135-148. doi:10.1007/s12105-012-0411-2. PMC 3642267. PMID 23233027. Rubin A, Davis J, Jreije K ... "Salivary Gland Neoplasms". Medscape.{{cite web}}: CS1 maint: multiple names: authors list (link) Updated: Jan 13, 2021}} ...
https://en.wikipedia.org/wiki/Mucoepidermoid_carcinoma
Juvenile active ossifying fibromaJuvenile active ossifying fibroma
Lester D. R. Thompson; Bruce M. Wenig (2011). Diagnostic Pathology: Head and Neck: Published by Amirsys. Hagerstown, MD: ... A juvenile active ossifying fibroma is a benign fibro-osseous neoplasm composed of mixture of stroma and bone characterized by ...
https://en.wikipedia.org/wiki/Juvenile_active_ossifying_fibroma
Extraskeletal myxoid chondrosarcomaExtraskeletal myxoid chondrosarcoma
... the paraspinal part and the head and neck region. [8] Incidence of the head and neck region is less than 5%. The cells in EMC ... EMC shows the smallest morphological variation between the tumors among all myxoid soft tissue neoplasms. The myxoid matrix has ... Extraskeletal myxoid chondrosarcoma (EMC) is a rare low-grade malignant mesenchymal neoplasm of the soft tissues, that differs ... Articles with short description, Short description matches Wikidata, Neoplasms, Oncology). ...
https://en.wikipedia.org/wiki/Extraskeletal_myxoid_chondrosarcoma
Skin cancer in horsesSkin cancer in horses
Sarcoids are the most common type of skin neoplasm and are the most common type of cancer overall in horses. Squamous-cell ... The appearance and number of sarcoids can vary, with some horses having single or multiple lesions, usually on the head, legs, ... eyes or neck, while nodular and verrucous sarcoids are common on the groin, penile sheath or face. Fibroblastic sarcoids have a ... making it the most common neoplasm reported in older horses. Carcinomas are tumors derived from epithelial cells and SCC ...
https://en.wikipedia.org/wiki/Skin_cancer_in_horses
Brain metastasisBrain metastasis
Head and neck cancer, 6% Neuroblastoma, 5% Gastrointestinal cancers, especially colorectal and pancreatic carcinoma, 3% ... Neoplasm Metastasis Cancer Brain tumor Tse V (10 November 2009). "Brain Metastasis". Medscape. Retrieved 13 January 2010. " ... Percy AK, Elveback LR, Okazaki H, Kurland LT (January 1972). "Neoplasms of the central nervous system. Epidemiologic ... the national survey of intracranial neoplasms". Neurology. 35 (2): 219-26. doi:10.1212/WNL.35.2.219. PMID 3969210. S2CID ...
https://en.wikipedia.org/wiki/Brain_metastasis
Proton therapyProton therapy
For recurrent head and neck cancer requiring reirradiation, proton therapy is able to maximize a focused dose of radiation to ... Two prominent examples are pediatric neoplasms (such as medulloblastoma) and prostate cancer. Irreversible long-term side ... This is particularly useful for head and neck tumors because of the anatomic constraints found in nearly all cancers in this ... "TREATING HEAD AND NECK CARCINOMA WITH PROTON THERAPY". IBA White Paper. 2016-10-04. Zachary Brownlee (2018). "Late ...
https://en.wikipedia.org/wiki/Proton_therapy
Glossary of communication disordersGlossary of communication disorders
Otolaryngologist Physician/surgeon who specializes in diseases of the ears, nose, throat, and head and neck. Otologist ... Laryngeal neoplasms Abnormal growths in the larynx (voice box) that can be cancerous or noncancerous. Laryngeal nodules ... Tinnitus Sensation of a ringing, roaring, or buzzing sound in the ears or head. It is often associated with many forms of ... involves attaching electrodes to the head to record electrical activity from the hearing nerve and other parts of the brain. ...
https://en.wikipedia.org/wiki/Glossary_of_communication_disorders
Sublingual spaceSublingual space
The sublingual space is a fascial space of the head and neck (sometimes also termed fascial spaces or tissue spaces). It is a ... Pathology arising from the sublingual gland is rare, however, sublingual gland neoplasms are predominantly malignant and thus ... 2007). Netter's head and neck anatomy for dentistry. Philadelphia, Pa.: Saunders Elsevier. p. 466. ISBN 9781929007882. Kenneth ... Articles using infobox templates with no data rows, Fascial spaces of the head and neck, Otorhinolaryngology, Oral and ...
https://en.wikipedia.org/wiki/Sublingual_space
Ossifying fibromyxoid tumourOssifying fibromyxoid tumour
Appearance in the head and neck is rare, but has been reported. Its malignancy has been characterized as "intermediate". ... Connective and soft tissue neoplasms, Tissues (biology), All stub articles, Neoplasm stubs). ...
https://en.wikipedia.org/wiki/Ossifying_fibromyxoid_tumour
Australasian Academy of Facial Plastic SurgeryAustralasian Academy of Facial Plastic Surgery
... head, and neck, including treatments for congenital defects, trauma and neoplasm-related defects, as well as cosmetic ...
https://en.wikipedia.org/wiki/Australasian_Academy_of_Facial_Plastic_Surgery
Murine respirovirusMurine respirovirus
SeV construct suppresses micrometastasis of head and neck squamous cell carcinoma in an orthotopic nude mouse model. Complete ... Its expression is also increased in a wide range of other malignant neoplasms. Factor X (F10) is frequently expressed in normal ... August 2019). "Sentinel Lymph Node-Targeted Therapy by Oncolytic Sendai Virus Suppresses Micrometastasis of Head and Neck ... Head & Neck. 41 (6): 1676-1686. doi:10.1002/hed.25642. PMID 30620422. S2CID 58561289. Yonemitsu Y, Ueda Y, Kinoh H, Hasegawa M ...
https://en.wikipedia.org/wiki/Murine_respirovirus
Pleomorphism (cytology)Pleomorphism (cytology)
El-Naggar, A.K.; Chan, J.C.K.; Grandis, J.R.; Takata, T.; Slootweg, P.J. (23 January 2017). WHO Classification of Head and Neck ... nuclear pleomorphism is one of the earliest hallmarks of cancer progression and a feature characteristic of malignant neoplasms ...
https://en.wikipedia.org/wiki/Pleomorphism_(cytology)
Browsing by Subject Head and Neck NeoplasmsBrowsing by Subject "Head and Neck Neoplasms"
Diet and the risk of head and neck squamous cell carcinomas in a Syrian population: a case-control study  ... Diet has not been investigated as a potential risk factor for head and neck squamous cell carcinomas in the Syrian Arab ... In situ characterization of B-and T-lymphocytes in basal cell carcinoma of the head and neck region  ... Twenty cases of basal cell carcinoma [‎BCC]‎ of the head and neck region were examined immunohistochemically for the detection ...
https://apps.who.int/iris/browse?authority=Head+and+Neck+Neoplasms&type=mesh
Browsing by Subject Head and Neck NeoplasmsBrowsing by Subject "Head and Neck Neoplasms"
Diet and the risk of head and neck squamous cell carcinomas in a Syrian population: a case-control study  ... Diet has not been investigated as a potential risk factor for head and neck squamous cell carcinomas in the Syrian Arab ... In situ characterization of B-and T-lymphocytes in basal cell carcinoma of the head and neck region  ... Twenty cases of basal cell carcinoma [‎BCC]‎ of the head and neck region were examined immunohistochemically for the detection ...
https://extranet.who.int/iris/restricted/browse?locale-attribute=en&type=mesh&authority=Head+and+Neck+Neoplasms
Search of: Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND Head and Neck Neoplasms AND Carcinoma AND...Search of: Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND Head and Neck Neoplasms AND Carcinoma AND...
4 Studies found for: Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND Head and Neck Neoplasms AND ... Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND Head and Neck Neoplasms AND Carcinoma AND Squamous ... Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND Head and Neck Neoplasms AND Carcinoma AND Squamous ... Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND Head and Neck Neoplasms AND Carcinoma AND Squamous ...
https://www.clinicaltrials.gov/ct2/results?term=Oral+Cancer+AND+Squamous+Cell+AND+cells+AND+Carcinoma%2C+Squamous+Cell+AND+Head+and+Neck+Neoplasms+AND+Carcinoma+AND+Squamous+Cell&map_cntry=PH
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma. | Scholars@DukeIncidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma. | [email protected]
Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma. ... Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma. Journal Article ( ... IMPORTANCE: Second primary malignant neoplasms (SPMNs) are the leading cause of death in survivors of head and neck squamous ... the largest SIRs and EARs were observed for cancers of the head and neck, lung, and esophagus. However, the risks of SPMN were ...
https://scholars.duke.edu/display/pub1449514
Neoplasm - WikipediaNeoplasm - Wikipedia
These epigenetic defects occurred in various cancers (e.g. breast, ovarian, colorectal and head and neck). Two or three ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... p. Neoplasm. ISBN 978-0781733908. .. *^ "II Neoplasms". International Statistical Classification of Diseases and Related Health ... The term neoplasm is a synonym of tumor. Neoplasia denotes the process of the formation of neoplasms/tumors, and the process is ...
https://en.wikipedia.org/wiki/Neoplasia
Results of search for 'su:{Head and neck neoplasms}' › WHO HQ Library catalog
The quality of life of head and neck cancer patients : a review of the literature / by Jenny Morris. by Morris, Jenny , ... Pathology and genetics of head and neck tumours / edited by Leon Barnes ... [et al.] by Barnes, Leon , Eveson, John W , ... Head and neck cancer : management of the difficult case / Paul J. Donald. by Donald, Paul J. ...
https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BHead%20and%20neck%20neoplasms%7D
HEAD AND NECK NEOPLASMS | SelfDecode | Genome AnalysisHEAD AND NECK NEOPLASMS | SelfDecode | Genome Analysis
... and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) ...
https://selfdecode.com/disease/head-and-neck-neoplasms/
Head And Neck Neoplasms Archives - Merck Clinical TrialsHead And Neck Neoplasms Archives - Merck Clinical Trials
Condition: Head And Neck Neoplasms This is a randomized, active-controlled, open-label study of pembrolizumab (Pembro) given ... head and neck squamous cell carcinoma (LA-HNSCC). Efficacy outcomes will be stratified by programmed cell death ligand 1 (PD-L1 ... of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck ...
https://www.merckclinicaltrials.com/condition/head-and-neck-neoplasms/
Find a Doctor in Your Area: Search Results - SharecareFind a Doctor in Your Area: Search Results - Sharecare
Head & Neck Neoplasms (6) * Gynecologic Neoplasms (5) * Endocrine System Neoplasms (5) * Renal Neoplasms & Resection (5) ...
https://www.sharecare.com/find-a-doctor/specialty/hematology/mn-minnesota/austin
solid neoplasm Clinical Research Trials | CenterWatchsolid neoplasm Clinical Research Trials | CenterWatch
solid neoplasm Clinical Research Trial Listings on CenterWatch ... semi; squamous cell carcinoma of the head and neck * 8 views * ...
https://www.centerwatch.com/clinical-trials/listings/search/?q=solid%20neoplasm
Thyroid cancer - papillary carcinoma: MedlinePlus Medical EncyclopediaThyroid cancer - papillary carcinoma: MedlinePlus Medical Encyclopedia
The thyroid gland is located inside the front of the lower neck. ... Head and Neck Pathology. 3rd ed. Philadelphia, PA: Elsevier; ... Malignant neoplasms of the thyroid gland. In: Thompson LDR, Bishop JA, eds. ... Operative Otolaryngology Head and Neck Surgery. 3rd ed. Philadelphia, PA: Elsevier; 2018:chap 82. ... High-dose external radiation treatments to the neck, especially during childhood, used to treat childhood cancer or some ...
https://medlineplus.gov/ency/article/000331.htm
Lymphomas of the Head and Neck: Practice Essentials, Background, PathophysiologyLymphomas of the Head and Neck: Practice Essentials, Background, Pathophysiology
A quarter of all extranodal lymphomas occur in the head and neck, and 8% of findings on supraclavicular fine-needle aspirate ... The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016 May 19. 127 (20):2375-90. ... Head and Neck Cancer - Resection and Neck Dissection * Microarray Technologies in the Diagnosis and Treatment of Head and Neck ... encoded search term (Lymphomas of the Head and Neck) and Lymphomas of the Head and Neck What to Read Next on Medscape ...
http://emedicine.medscape.com/article/854110-overview
The pathology of head and neck tumors: Neoplasms of cartilage, bone, and the notochord, part 7<...The pathology of head and neck tumors: Neoplasms of cartilage, bone, and the notochord, part 7<...
The pathology of head and neck tumors: Neoplasms of cartilage, bone, and the notochord, part 7. Head & Neck Surgery. 1980 Jan 1 ... The pathology of head and neck tumors: Neoplasms of cartilage, bone, and the notochord, part 7. Head & Neck Surgery, 3(1), 43- ... The pathology of head and neck tumors: Neoplasms of cartilage, bone, and the notochord, part 7, Head & Neck Surgery, vol. 3, ... The pathology of head and neck tumors : Neoplasms of cartilage, bone, and the notochord, part 7. In: Head & Neck Surgery. 1980 ...
https://ohsu.pure.elsevier.com/en/publications/the-pathology-of-head-and-neck-tumors-neoplasms-of-cartilage-bone-2
NEOPLASMS INVOLVING THE MIDDLE EAR | JAMA Otolaryngology-Head & Neck Surgery | JAMA NetworkNEOPLASMS INVOLVING THE MIDDLE EAR | JAMA Otolaryngology-Head & Neck Surgery | JAMA Network
In no field of otology is there so much confusion as in the treatment of neoplasms of the middle ear. The general attitude has ... In no field of otology is there so much confusion as in the treatment of neoplasms of the middle ear. The general attitude has ... In the past twelve years 15 patients with neoplasms involving the middle ear were seen by the otologic staff of the ... NEOPLASMS INVOLVING THE MIDDLE EAR. Arch Otolaryngol. 1935;22(5):548-553. doi:10.1001/archotol.1935.00640030565002 ...
https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/557600
Paediatric head and neck malignant neoplasms: A brazilian retrospective study | Med. oral patol. oral cir. bucal (Internet);28...Paediatric head and neck malignant neoplasms: A brazilian retrospective study | Med. oral patol. oral cir. bucal (Internet);28...
Paediatric head and neck malignant neoplasms: A brazilian retrospective study Paediatric head and neck malignant neoplasms: A ... Oral and maxillofacial malignant neoplasms in children and adolescents are uncommon and the accuracy of provisional diagnoses ... Sarcomas were the most prevalent malignant neoplasms (19/32; 59%), followed by carcinomas (7/32; 22%), lymphomas (5/32; 16%) ...
https://pesquisa.bvsalud.org/portal/resource/pt/ibc-216695
Merkel Cell Tumors of the Head and Neck: Overview, Pathophysiology and Etiology, Clinical FeaturesMerkel Cell Tumors of the Head and Neck: Overview, Pathophysiology and Etiology, Clinical Features
More than one half of all MCCs occur on the head and neck. ... MCC is a rare neoplasm. In the United States, the estimated ... encoded search term (Merkel Cell Tumors of the Head and Neck) and Merkel Cell Tumors of the Head and Neck What to Read Next on ... Merkel cell carcinoma of the head and neck: favorable outcomes with radiotherapy. Head Neck. 2016 Apr. 38 Suppl 1:E452-8. [QxMD ... Improved local and regional control with radiotherapy for Merkel cell carcinoma of the head and neck. Head Neck. 2017 Jan. 39 ( ...
https://www.medscape.com/answers/853565-10501/when-is-biopsy-indicated-in-the-diagnosis-of-a-merkel-cell-carcinoma-mcc-tumor
Stereotactic body radiotherapy for oligometastatic lung tumorsStereotactic body radiotherapy for oligometastatic lung tumors
Head and Neck Neoplasms * Humans * Kidney Neoplasms * Lung Neoplasms / mortality * Lung Neoplasms / secondary* ... The primary involved organs were the lung (n = 15), colorectum (n = 9), head and neck (n = 5), kidney (n = 3), breast (n = 1), ...
https://pubmed.ncbi.nlm.nih.gov/18374506/
Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous...Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous...
Neoplasms. Disease Attributes. Pathologic Processes. Neoplasms, Squamous Cell. Head and Neck Neoplasms. Neoplasms by Site. ... Squamous Cell Carcinoma of Head and Neck. Recurrence. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. ... Locally Recurrent Head and Neck Squamous Cell Carcinoma Nasopharyngeal Squamous Cell Carcinoma Sinonasal Squamous Cell ... Giving birinapant with IMRRT may lower the chance of head and neck squamous cell carcinoma growing or spreading. ...
https://clinicaltrials.gov/ct2/show/NCT03803774
C47.0 - Malignant neoplasm of peripheral nerves of head, face and neck - ICD List 2023C47.0 - Malignant neoplasm of peripheral nerves of head, face and neck - ICD List 2023
... face and neck. Synonyms: malignant neoplasm of peripheral nerves of head, face and ne ... Billable ICD-10 code to specify malignant neoplasm of prph nerves of head, ... Malignant neoplasm of prph nerves of head, face and neck. Long Description:. Malignant neoplasm of peripheral nerves of head, ... Malignant neoplasm of peripheral nerves of head, face and neck. *Malignant nerve sheath neoplasm of peripheral nerve of head ...
https://icdlist.com/icd-10/C47.0
Infratentorial Tumor (Infratentorial Neoplasms): Symptoms, Diagnosis and Treatment - SymptomaInfratentorial Tumor (Infratentorial Neoplasms): Symptoms, Diagnosis and Treatment - Symptoma
Infratentorial Neoplasms): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. ... Position the patient to avoid extreme hip or neck flexion and maintain the head in midline, neutral position to prevent ... Short Neck For execution of the posterior fossa surgery, morbidly obese patients with short necks may benefit from the sitting ... 2313 Epigenetics and Gene Silencing 478 2319 Differential Diagnosis 2322 Parancoplastic Syndromes 2343 Head and Neck Cancer ...
https://www.symptoma.com/en/info/infratentorial-tumor
SciELO - Brazil - ESOPHAGEAL CARCINOMA: IS SQUAMOUS CELL CARCINOMA DIFFERENT DISEASE COMPARED TO ADENOCARCINOMA? A transversal...SciELO - Brazil - ESOPHAGEAL CARCINOMA: IS SQUAMOUS CELL CARCINOMA DIFFERENT DISEASE COMPARED TO ADENOCARCINOMA? A transversal...
Main associated neoplasms. Head and neck tumors are much more often found in association to squamous cell carcinoma patients, ... Main associated neoplasms. Head and neck tumors are much more often found in association to squamous cell carcinoma patients, ... TABLE 2 Main associated neoplasms. Head and neck tumors are much more often found in association to squamous cell carcinoma ... As seen in Table 2, the neoplasms associated with SCC were predominantly head and neck tumors. ...
https://www.scielo.br/j/ag/a/4rrxQCwW3nyG7cdPB3Pfgdg/?lang=en
DeCS 2016 - June 12, 2016 versionDeCS 2016 - June 12, 2016 version
Head and Neck Cancer use Head and Neck Neoplasms Head and Neck Neoplasms ... Head and Neck Squamous Cell Carcinoma use Squamous Cell Carcinoma of Head and Neck ... Head Necrosis, Femur use Femur Head Necrosis Head Neoplasms use Head and Neck Neoplasms ... Head, Neck Neoplasms use Head and Neck Neoplasms Head, Optic Nerve use Optic Disk ...
https://decs.bvs.br/I/DeCS2016_Alfab-H.htm
Head And Neck Neoplasms; Neck Neoplasms; Cancer of Head and Neck; Head and Neck Cancer; Head Cancer; Neck Cancer; Neoplasms,...Head And Neck Neoplasms; Neck Neoplasms; Cancer of Head and Neck; Head and Neck Cancer; Head Cancer; Neck Cancer; Neoplasms,...
Neck Neoplasms; Cancer of Head and Neck; Head and Neck Cancer; Head Cancer; Neck Cancer; Neoplasms, Upper Aerodigestive Tract; ... Upper Aerodigestive Tract Neoplasms. On-line free medical diagnosis assistant. Ranked list of possible diseases from either ... Head And Neck Neoplasms; Neck Neoplasms; Cancer of Head and Neck; Head and Neck Cancer; Head Cancer; Neck Cancer; Neoplasms, ...
https://lookfordiagnosis.com/results.php?symptoms=Head+And+Neck+Neoplasms%3B%20Neck%20Neoplasms%3B%20Cancer%20of%20Head%20and%20Neck%3B%20Head%20and%20Neck%20Cancer%3B%20Head%20Cancer%3B%20Neck%20Cancer%3B%20Neoplasms%2C%20Upper%20Aerodigestive%20Tract%3B%20Upper%20Aerodigestive%20Tract%20Neoplasms&lang=1&parent=%2F&mode=F&therapy_ap=1
Diagnoses of Temporomandibular Disorders in Patients Treated with Radiotherapy for Malignant Neoplasms of the Head and Neck:...Diagnoses of Temporomandibular Disorders in Patients Treated with Radiotherapy for Malignant Neoplasms of the Head and Neck:...
Head and neck malignant neoplasms are usually treated with surgery combined with radiotherapy, causing alterations in the ... Diagnoses of Temporomandibular Disorders in Patients Treated with Radiotherapy for Malignant Neoplasms of the Head and Neck: ... Diagnoses of temporomandibular disorders in patients treated with radiotherapy for malignant neoplasms of the head and neck: ... in patients treated with radiotherapy for head and neck cancer. Four (4) electronic bibliographic databases were reviewed ...
http://ijodontostomatology.com/en/articulo/diagnoses-of-temporomandibular-disorders-in-patients-treated-with-radiotherapy-for-malignant-neoplasms-of-the-head-and-neck-scoping-review/
Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)
Categories: Head and Neck Neoplasms Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Head+and+Neck+Neoplasms&parentid=17747&catid=12227
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas | Cancer Gene TherapyTMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas | Cancer Gene Therapy
... lymphoid neoplasm diffuse large B-cell lymphoma, DLBC; esophageal carcinoma, ESCA; glioblastoma multiforme, GBM; head and neck ...
https://www.nature.com/articles/s41417-021-00414-5?error=cookies_not_supported&code=e5d19d75-acec-4aba-adcd-89945ee0f0ec
Find a Doctor in Your Area: Search Results - SharecareFind a Doctor in Your Area: Search Results - Sharecare
Head & Neck Neoplasms (10) * Pancreatic Neoplasms (10) * Skeletal System Neoplasms (8) * Urinary System Neoplasms (7) ...
https://www.sharecare.com/find-a-doctor/specialty/oncology/fl-florida/crestview
Facial nerve paralysis secondary to occult malignant neoplasms<...
Facial nerve paralysis secondary to occult malignant neoplasms. In: Otolaryngology - Head and Neck Surgery. 2004 ; Vol. 130, No ... Facial nerve paralysis secondary to occult malignant neoplasms. Otolaryngology - Head and Neck Surgery. 2004 Apr;130(4):459-465 ... Facial nerve paralysis secondary to occult malignant neoplasms. Otolaryngology - Head and Neck Surgery, 130(4), 459-465. https ... Facial nerve paralysis secondary to occult malignant neoplasms, Otolaryngology - Head and Neck Surgery, vol. 130, no. 4, pp. ...
https://jhu.pure.elsevier.com/en/publications/facial-nerve-paralysis-secondary-to-occult-malignant-neoplasms-4
Bruce Wenig | MoffittBruce Wenig | Moffitt
Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms. Head Neck Pathol. 2022 Mar.16(1):123-142. ... Update From The 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Nasopharynx. Head Neck ... Recently described sinonasal tract lesions/neoplasms: considerations for the new world health organization book. Head Neck ... the Section Head of Anatomic Pathology External Network Consultation Services and the Section Head of Moffitts Head and Neck- ...
https://moffitt.org/providers/bruce-wenig/
CancerCarcinomaMalignant neoplasmTumorsRadiotherapyHeterogeneous group of malignant neoplasmsCancersPathologyRecurrenceTumorBenign neoplasmsCarcinomasSurgeryOncologyResectionDisordersOral CavityBehaviorNeoplasticMELANOMA2022ThyroidSymptomsBreastDiagnosis and TreatmentClassificationTissueLymphoid
Cancer35
  • A neoplasm can be benign , potentially malignant, or malignant ( cancer ). (wikipedia.org)
  • Malignant neoplasms are commonly called cancer. (wikipedia.org)
  • Secondary neoplasm refers to any of a class of cancerous tumor that is either a metastatic offshoot of a primary tumor, or an apparently unrelated tumor that increases in frequency following certain cancer treatments such as chemotherapy or radiotherapy . (wikipedia.org)
  • Rarely there can be a metastatic neoplasm with no known site of the primary cancer and this is classed as a cancer of unknown primary origin . (wikipedia.org)
  • Head and neck cancer : management of the difficult case / Paul J. Donald. (who.int)
  • The quality of life of head and neck cancer patients : a review of the literature / by Jenny Morris. (who.int)
  • Esophageal cancer is one of the leading causes of mortality among the neoplasms that affect the gastrointestinal tract. (scielo.br)
  • There was a clear association between squamous cell cancer and head and neck cancers, as well as certain habits, such as smoking and alcoholism, while adenocarcinoma cancer showed more association with gastric cancer and gastroesophageal reflux disease. (scielo.br)
  • An scoping review of the literature was carried out presenting the most up-to-date information regarding the diagnoses and relevant outcomes of temporomandibular disorders (TMDs) in patients treated with radiotherapy for head and neck cancer. (ijodontostomatology.com)
  • RÉSUMÉ Des études en milieu hospitalier ont révélé des fréquences relatives très élevées du cancer oropharyngé au Yémen. (who.int)
  • La présente étude a estimé les fréquences relatives du cancer de la cavité buccale et du pharynx chez des patients yéménites atteints de cancers enregistrés en 2007 et 2008. (who.int)
  • Active smoking at the time of diagnosis of a first head & neck (H&N) or lung cancer is associated with a worse cancer outcome and increased mortality. (biomedcentral.com)
  • Tobacco smoking is the most important risk factor for lung cancer [ 1 ], while tobacco and alcohol conjointly account for the occurrence of 67-84% of the head and neck (H&N) cancers [ 2 ]. (biomedcentral.com)
  • An understanding of regional anatomy and the status of regional lymph nodes is critical to the care of patients with head and neck cancer. (uofmhealth.org)
  • Personal history of head and neck cancer. (uofmhealth.org)
  • The Head and Neck Tumor Center at the Medical University of South Carolina (MUSC) is one of the largest programs in the US devoted to the care of the head and neck cancer patient. (ahns.info)
  • Overall, 750 - 800 new patients with head and neck cancer are evaluated at MUSC annually. (ahns.info)
  • Physical Therapy and related fields working together to provide the optimal care for head and neck cancer patients. (ahns.info)
  • Currently, the program has 15 open clinical trials in head and neck cancer, along with 10 NIH-funded basic science laboratories or translational research programs with over four million dollars annually in research funding. (ahns.info)
  • The Fellowship in Surgical Oncology and Microvascular Reconstruction of the Head and Neck at MUSC provides the highest level of training in the management and surgical treatment of head and neck cancer. (ahns.info)
  • In addition to working with senior faculty in a clinical setting, the Fellow also has an independent head and neck cancer clinic In this setting, the fellow evaluates new patients each week and has primary management responsibility for all patients seen in their clinic, with attending input and oversight as needed. (ahns.info)
  • abstract = "PURPOSE OF REVIEW: The aim of this article is to examine the need for screening of endocrine dysfunction following treatment of head and neck cancer. (vu.nl)
  • RECENT FINDINGS: The incidence of occult hypothyroidism following treatment of head and neck cancer is high. (vu.nl)
  • Although the incidence of hypoparathyroidism after treatment for head and neck cancer is low, testing of serum calcium is easily performed during thyroid function evaluation. (vu.nl)
  • SUMMARY: Owing to the high incidence of endocrine dysfunction, all head and neck cancer patients who undergo treatment of the lower neck, nasopharynx or base of skull need regular endocrine evaluation during long-term follow-up to determine the need to start hormone replacement therapy and maintain optimal quality of life. (vu.nl)
  • de Bree, R, Lips, PTAM & Leemans, CR 2008, ' The need for patients' endocrine function vigilance following treatment of head and neck cancer ', Current Opinion in Otolaryngology & Head and Neck Surgery , vol. 16, no. 2, pp. 154-157. (vu.nl)
  • Dysphagia (swallowing difficulty) is one of the most common and debilitating sequelae of head and neck cancer (HNC). (biomedcentral.com)
  • His current interests are head-and-neck and prostate cancer, CNS neoplasms and neuroendocrine tumors. (philips.dk)
  • If your provider suspects that the cancer has spread to lymph nodes in the neck, these will also be removed. (adam.com)
  • The treatment of head and neck cancer (HNC) is often radical and the patient's journey challenging, especially for individuals who are struggling with pre-existing mental health problems and who lack social support. (hud.ac.uk)
  • For subjects with an oral cavity cancer, the decision for definitive treatment with RT requires consultation with the head and neck surgeon and the siteâ? (who.int)
  • Socioeconomic status, access to care, risk factor patterns, and stage at diagnosis for head and neck cancer among black and white patients. (who.int)
  • A retrospective cross-sectional study was developed by analyzing the medical records of patients treated at the Aristides Maltez Hospital from January 2008 to December 2015, with diagnosis of confirmed head and neck cancer. (bvsalud.org)
  • Ovarian cancer natural treatment Research Cures Cancer - Ovarian Cancer - MedscapeTV oxiuri de la ce apar Hpv foot warts treatment ovarian cancer jokes cancer head, human papillomavirus infection deadly hpv virus gyogyitasa. (etigararunway.ro)
  • Vinil parazitii bad joke Adenom clasifică nemathelminthes hewan coloid icd-9, Metastatic cancer neck icd 10 Uterine cancer awareness month Breast Cancer Ovarian cancer jokes Month - cancer cerebral estadio 4 Afecțiuni tratate Quick Search: To find out which conditions can be treated in a minimally invasive way by interventional radiologists, click on the corresponding section below. (etigararunway.ro)
Carcinoma15
  • Twenty cases of basal cell carcinoma [‎BCC]‎ of the head and neck region were examined immunohistochemically for the detection of T- and Blymphocytes. (who.int)
  • Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma. (duke.edu)
  • IMPORTANCE: Second primary malignant neoplasms (SPMNs) are the leading cause of death in survivors of head and neck squamous cell carcinoma (HNSCC). (duke.edu)
  • Potentially-malignant neoplasms include carcinoma in situ . (wikipedia.org)
  • [12] [13] Some neoplasms do not form a tumor - these include leukemia and most forms of carcinoma in situ . (wikipedia.org)
  • This is a randomized, active-controlled, open-label study of pembrolizumab (Pembro) given prior to surgery and pembrolizumab in combination with standard of care radiotherapy (with or without cisplatin), as post-surgical therapy in treatment naïve participants with newly diagnosed Stage III/IVA, resectable, locoregionally advanced, head and neck squamous cell carcinoma (LA-HNSCC). (merckclinicaltrials.com)
  • This phase I trial studies the side effects and best dose of birinapant when given together with intensity modulated re-irradiation therapy (IMRRT) in treating patients with head and neck squamous cell carcinoma that has come back at or near the same place as the original (primary) tumor (locally recurrent). (clinicaltrials.gov)
  • Giving birinapant with IMRRT may lower the chance of head and neck squamous cell carcinoma growing or spreading. (clinicaltrials.gov)
  • I. Determine the objective response rate of patients with locoregionally recurrent head and neck squamous cell carcinoma (HNSCC) treated with re-irradiation and birinapant. (clinicaltrials.gov)
  • This study goal was to describe and graduate the local and systemic toxicity of intratumoral injections of HSP (Heat Shock Protein) 65 DNA vaccine in advanced-stage head and neck squamous cell carcinoma (SCCHN) patients and to define the highest well tolerated dose for them. (usp.br)
  • However, studies of asbestos and cancers of the larynx or pharynx with adequate sample size that control for major head and neck squamous cell carcinoma (HNSCC) risk factors remain relatively sparse. (cdc.gov)
  • Use of in situ hybridization to detect human papillomavirus in head and neck squamous cell carcinoma patients without a history of alcohol or tobacco use. (duke.edu)
  • CONTEXT: Head and neck squamous cell carcinoma is commonly associated with tobacco and alcohol use. (duke.edu)
  • CONCLUSIONS: These results demonstrate that the new probe sets for HPV can be used very efficiently in clinical pathology material of head and neck squamous cell carcinoma. (duke.edu)
  • Squamous cell carcinoma is an aggressive epithelial malignancy of the upper aerodigestive tract comprising 90% of all head-and-neck squamous cell carcinoma (HNSCC). (jomfp.in)
Malignant neoplasm2
  • C47.0 is a billable ICD-10 code used to specify a medical diagnosis of malignant neoplasm of peripheral nerves of head, face and neck. (icdlist.com)
  • The most common malignant neoplasm of the base of the tongue is SCC. (medscape.com)
Tumors5
  • Rice, Dale H. / The pathology of head and neck tumors : Neoplasms of cartilage, bone, and the notochord, part 7 . (elsevier.com)
  • Results: Carotid body tumors were the most common paragangliomas of the head and neck (34 cases). (elsevier.com)
  • The 37 malignant tumors included lymphomas (eight in patients receiving cyclosporine and four in patients not given cyclosporine) and carcinomas of the skin and lips (11), head and neck (five), colon and rectum (three), uterus (two), vulva (two), lung (one), and urinary bladder (one). (elsevier.com)
  • The neoplasms of the skin, vulva, uterine cervix, and urinary bladder were low-grade malignant tumors. (elsevier.com)
  • Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive tumor, uncommonly occurring on the head and neck where these deeply infiltrating tumors might violate underlying neurovascular structures. (jcadonline.com)
Radiotherapy2
  • Head and neck malignant neoplasms are usually treated with surgery combined with radiotherapy, causing alterations in the maxillofacial structures, leaving sequelae in the tissues related to the temporomandibular joint (TMJ) and associated muscles. (ijodontostomatology.com)
  • Professor and Head of TYKS's Department of Oncology and Radiotherapy, where he started in 1985. (philips.dk)
Heterogeneous group of malignant neoplasms1
  • Cancers of the oral cavity and throat (oral and pharyngeal cancers) represent a heterogeneous group of malignant neoplasms. (krebsdaten.de)
Cancers5
  • Overall, the largest SIRs and EARs were observed for cancers of the head and neck, lung, and esophagus. (duke.edu)
  • [7] Malignant neoplasms are also simply known as cancers and are the focus of oncology . (wikipedia.org)
  • and MELANOMA and non-melanoma skin cancers of the head and neck. (selfdecode.com)
  • A cohort study in the Netherlands of 2510 exposed and 2199 unexposed persons did not document a statistically significant increase in head and neck cancers in the exposed group (2). (cdc.gov)
  • Background: The head and neck (H/N) is a common site for childhood cancers. (bvsalud.org)
Pathology5
  • Dr. Wenig also serves as the Section Head of Anatomic Pathology External Network Consultation Services and the Section Head of Moffitt's Head and Neck-Endocrine Pathology Program. (moffitt.org)
  • Following his Fellowship, Dr. Wenig was a Staff Pathologist (1987-1998) for the Department of Otolaryngic-Endocrine Pathology at the Armed Forces Institute of Pathology, and also served as Chief, Division of Otolaryngic Pathology, Department of Endocrine and Otorhinolaryngic Head and Neck Pathology, Washington, DC. (moffitt.org)
  • He has published extensively in peer-reviewed journals as well as authoring/editing several textbooks and numerous book chapters on head-and-neck and endocrine pathology. (moffitt.org)
  • The third edition of his singly authored book, The Atlas of Head and Neck Pathology, was published in 2016. (moffitt.org)
  • There is a comprehensive didactic curriculum consisting of weekly seminars, clinical pathologic conferences, morbidity reviews, case reviews, oral pathology seminars, trauma conferences, surgical-orthodontic conferences, journal club, medical decision making course and head and neck tumor board. (umkc.edu)
Recurrence1
  • ACC tends to be a slow growing, but aggressive neoplasm, with a remarkable capacity for recurrence. (medpagetoday.com)
Tumor9
  • In modern English, tumor is used as a synonym for neoplasm (a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears enlarged in size. (wikipedia.org)
  • Optic nerve or chiasmal defect: visual deficits, Marcus Gunn pupil (afferent pupillary defect), bitemporal hemianopsia (classic chiasmal tumor), unilateral or bilateral nystagmus with head tilt (chiasmal). (symptoma.com)
  • The focus of the MUSC Head and Neck Tumor Center is on providing compassionate, comprehensive and innovative care to all patients and their families. (ahns.info)
  • In 2011, the Head and Neck Tumor Center was cited as the best interdisciplinary clinical program at MUSC. (ahns.info)
  • The Head and Neck Tumor Center also has an extremely robust research portfolio. (ahns.info)
  • The MUSC Head and Neck Tumor Center is a division of the MUSC Department of Otolaryngology-Head and Neck Surgery but was approved as an institutional center at MUSC crossing many disciplines. (ahns.info)
  • 10,11 Given the complex neurovascular anatomy of the head and neck, compounded with the propensity for deep tissue invasion, neurologic deficits, either from direct tumor invasion into neural tissue or damage to nerves during surgical treatment, are a reasonably expected complication. (jcadonline.com)
  • Given the locally aggressive nature of the tumor, and presumed proximity to the temporal branch of the facial nerve, a multidisciplinary surgical approach (intraoperative Mohs micrographic surgery [iMMS]) was planned with both Mohs and otolaryngology-head and neck surgeons. (jcadonline.com)
  • The head and neck surgeon dissected out the temporal nerve to preserve function and allow complete tumor extirpation from the surrounding tissue. (jcadonline.com)
Benign neoplasms2
  • benign neoplasms , in situ neoplasms , malignant neoplasms , and neoplasms of uncertain or unknown behavior. (wikipedia.org)
  • Neoplasms were relatively infrequent, including six malignant neoplasms and 14 benign neoplasms. (elsevier.com)
Carcinomas1
  • A genetic predisposition for the development of carcinomas of the head and neck area is also assumed to exist, since familial clustering has been observed. (krebsdaten.de)
Surgery5
  • Cummings Otolaryngology: Head and Neck Surgery. (medlineplus.gov)
  • Head & Neck Surgery , 3 (1), 43-57. (elsevier.com)
  • For execution of the posterior fossa surgery, morbidly obese patients with short necks may benefit from the sitting position. (symptoma.com)
  • Otolaryngology - Head and Neck Surgery , 130 (4), 459-465. (elsevier.com)
  • The soft-tissue defect was repaired by our head and neck surgery colleagues using a radial forearm free flap. (jcadonline.com)
Oncology2
  • Advancing Education, Research, and Quality of Care for the Head and Neck oncology patient. (ahns.info)
  • The mission of the AHNS is to advance Education, Research, and Quality of Care for the head and neck oncology patient. (ahns.info)
Resection1
  • Neoplasms present at the margins of resection have a poor prognosis. (elsevier.com)
Disorders1
  • 4. The criteria for service connection for a right foot disability, a bilateral upper extremity disability to include radiculopathy and neuropathy, a bilateral lower extremity disability to include radiculopathy and neuropathy, a respiratory disability to include sinusitis, a left shoulder disability, a neck disability, a back disability, a sleep disorder, and acquired psychiatric disorders including PTSD, depression and anxiety have not been met. (va-claim.com)
Oral Cavity1
  • Tumours of the oropharynx are most frequently diagnosed in men, while malignant neoplasms of the oral cavity and lip are most common in women. (krebsdaten.de)
Behavior1
  • For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. (icdlist.com)
Neoplastic1
  • Dr. Wenig's main clinical interests are in diseases of the head and neck and of endocrine organs including oncologic and non-neoplastic diseases. (moffitt.org)
MELANOMA1
  • A multiple stepwise logistic regression analysis shows that histologic regression is more likely to be found in a malignant melanoma that is level III or less, more than 10 mm in diameter, associated with solar elastosis, located on an anatomic area other than the head or neck, and when there are areas of whiteness clinically. (cdc.gov)
20221
  • Dr. Zeeshan Ansar participated in a virtual activity on, ' The 1st Congress on Myeloproliferative Neoplasms controversies and debates ', European board for accreditation in Haematology- EBAH, November 11-12, 2022. (aku.edu)
Thyroid3
  • The thyroid gland is a butterfly-shaped gland located inside the front of the lower neck. (medlineplus.gov)
  • Management of thyroid neoplasms. (medlineplus.gov)
  • This may reveal a lump in the thyroid or swollen lymph nodes in the neck. (adam.com)
Symptoms2
  • Since their return, many Persian Gulf War veterans (GWVs) have presented with various medical symptoms, including those related to the head and neck. (elsevier.com)
  • 11651 ='Nailbiting' 11652 ='Thumbsucking' 12000 ='Abnormal involuntary movements' 12050 ='Convulsions' 12070 ='Symptoms of head, NEC' 12100 ='Headache, pain in head' 12150 ='Memory, disturbances of' 12200 ='Disturbances of sensation' 12201 ='Loss of feeling (anesthesia)' 12202 ='Increased sensation (hyperesthesia)' 12203 ='Abnormal sensation (paresthesia)' 12204 ='Other disturbances of sense, includin. (cdc.gov)
Breast1
  • The primary involved organs were the lung (n = 15), colorectum (n = 9), head and neck (n = 5), kidney (n = 3), breast (n = 1), and bone (n = 1). (nih.gov)
Diagnosis and Treatment1
  • Awareness of risk (such as previous radiation therapy to the neck) can allow earlier diagnosis and treatment. (adam.com)
Classification1
  • The WHO Classification of Head and Neck Tumours is the ninth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. (who.int)
Tissue3
  • The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. (wikipedia.org)
  • Depending on their level of interest, the fellow will participate in 50 - 100 cases of microvascular free tissue transfer for head and neck reconstruction. (ahns.info)
  • Bartonella species in tissue specimens has become the cases) or neoplasm (3 cases). (cdc.gov)
Lymphoid1
  • For lymphoid neoplasms, e.g. lymphoma and leukemia , clonality is proven by the amplification of a single rearrangement of their immunoglobulin gene (for B cell lesions) or T cell receptor gene (for T cell lesions). (wikipedia.org)