Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
The upper part of the human body, or the front or upper part of the body of an animal, typically separated from the rest of the body by a neck, and containing the brain, mouth, and sense organs.
The part of a human or animal body connecting the HEAD to the rest of the body.
Discomfort or more intense forms of pain that are localized to the cervical region. This term generally refers to pain in the posterior or lateral regions of the neck.
Voluntary or involuntary motion of head that may be relative to or independent of body; includes animals and humans.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed)
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Fractures of the short, constricted portion of the thigh bone between the femur head and the trochanters. It excludes intertrochanteric fractures which are HIP FRACTURES.
Neoplasms containing cyst-like formations or producing mucin or serum.
Tumors or cancer of the MOUTH.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Tumors or cancer of the SALIVARY GLANDS.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Tumors or cancer of the human BREAST.
Metastatic breast cancer characterized by EDEMA and ERYTHEMA of the affected breast due to LYMPHATIC METASTASIS and eventual obstruction of LYMPHATIC VESSELS by the cancer cells.
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.
The metabolism of drugs and their mechanisms of action.
The inferior region of the skull consisting of an internal (cerebral), and an external (basilar) surface.
An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)
Surgical procedures conducted with the aid of computers. This is most frequently used in orthopedic and laparoscopic surgery for implant placement and instrument guidance. Image-guided surgery interactively combines prior CT scans or MRI images with real-time video.
A surgical specialty concerned with the study and treatment of disorders of the ear, nose, and throat.
A transcription factor found in BACTERIA that positively and negatively regulates the expression of proteins required for the uptake and catabolism of L-ARABINOSE.
A mass of histologically normal tissue present in an abnormal location.
The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.
Brain tissue herniation through a congenital or acquired defect in the skull. The majority of congenital encephaloceles occur in the occipital or frontal regions. Clinical features include a protuberant mass that may be pulsatile. The quantity and location of protruding neural tissue determines the type and degree of neurologic deficit. Visual defects, psychomotor developmental delay, and persistent motor deficits frequently occur.
A mass of KERATIN-producing squamous EPITHELIUM that resembles an inverted (suck-in) bag of skin in the MIDDLE EAR. It arises from the eardrum (TYMPANIC MEMBRANE) and grows into the MIDDLE EAR causing erosion of EAR OSSICLES and MASTOID that contains the INNER EAR.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL.
Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.
Diseases of the facial nerve or nuclei. Pontine disorders may affect the facial nuclei or nerve fascicle. The nerve may be involved intracranially, along its course through the petrous portion of the temporal bone, or along its extracranial course. Clinical manifestations include facial muscle weakness, loss of taste from the anterior tongue, hyperacusis, and decreased lacrimation.
Severe or complete loss of facial muscle motor function. This condition may result from central or peripheral lesions. Damage to CNS motor pathways from the cerebral cortex to the facial nuclei in the pons leads to facial weakness that generally spares the forehead muscles. FACIAL NERVE DISEASES generally results in generalized hemifacial weakness. NEUROMUSCULAR JUNCTION DISEASES and MUSCULAR DISEASES may also cause facial paralysis or paresis.
The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and SALIVARY GLANDS, and convey afferent information for TASTE from the anterior two-thirds of the TONGUE and for TOUCH from the EXTERNAL EAR.
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.
The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.

Syndecan-1 expression has prognostic significance in head and neck carcinoma. (1/5027)

The syndecans are a family of cell-surface heparan sulphate proteoglycans that regulate cell behaviour by binding extracellular matrix molecules such as growth factors. The syndecan family has four members, of which syndecan-1 is the most studied and best characterized. We have studied the prognostic significance of syndecan-1 expression in squamous cell carcinoma (SCC) of the head and neck treated with surgery and post-operative radiotherapy. Paraffin-embedded tissue samples taken from 175 patients with primary SCC, followed up from 2 to 15 years after surgery, were studied for expression of syndecan-1 by immunohistochemistry. A low number (< or =50%, the median value) of syndecan-1-positive tumour cells was associated with low histological grade of differentiation (P<0.0001), a large primary tumour size (T1-2 vs. T3-4, P = 0.02), positive nodal status (NO vs. N1-3, P = 0.0006), and high clinical stage (stage I or II vs. III or IV, P<0.0001). Low syndecan-1 expression was also associated with unfavourable overall survival in a univariate analysis (P = 0.001). In a multivariate survival analysis, the clinical stage and syndecan-1 expression were the only independent prognostic factors. We conclude that syndecan-1 is a novel prognostic factor in SCC of the head and neck treated with surgery and post-operative radiotherapy.  (+info)

[3H]gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell line. (2/5027)

Cellular uptake of many chemotherapeutic nucleoside analogs is dependent on the activity of a family of nucleoside transport proteins located in the cell plasma membrane. In the present study, we examined the role of these transporters in the accumulation of gemcitabine by a human head and neck squamous carcinoma cell line. The uptake of [3H]gemcitibine was compared with that of [3H]uridine and [3H]formycin B in the parent cell line (HN-5a) and in a gemcitabine-resistant variant (GEM-8e). The HN-5a and GEM-8e cells were similar in their transport characteristics and expressed predominantly the es (equilibrative, inhibitor-sensitive) transporter subtype; less than 10% of the influx of [3H]formycin B or [3H]uridine was mediated by the ei (equilibrative inhibitor-resistant) system, and there was no evidence for Na+-dependent nucleoside transporters. [3H]Gemcitabine (10 microM) entered these cells via both the es and ei transporters with an initial rate of uptake similar to that seen with the use of [3H]formycin B or [3H]uridine. In addition, ATP-replete cells accumulated significantly less [3H]gemcitabine than did ATP-depleted cells, which is indicative of an active efflux mechanism for gemcitabine. These results show that gemcitabine is a substrate for both the es and ei nucleoside transporters of HN-5a and GEM-8e cells and that gemcitabine resistance of the GEM-8e cells cannot be attributed to changes in transporter activity. Further studies to define the characteristics of the putative efflux mechanism are clearly warranted because this system has the potential to significantly affect the clinical efficacy of gemcitabine.  (+info)

Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer. (3/5027)

5-Fluorouracil (5-FU) is an effective enhancer of radiation therapy (RT) in head and neck cancers. Due to rapid, predominantly hepatic metabolism by dihydropyrimidine dehydrogenase (DPD) and suggested clinical benefit from prolonged drug exposure, 5-FU is commonly given by continuous infusion. Eniluracil is a novel DPD-inactivator designed to prolong the half-life of 5-FU and provide sustained plasma concentrations of 5-FU with oral dosing. We conducted a Phase I study of the safety and efficacy of eniluracil given with oral 5-FU in patients receiving concurrent RT for recurrent or advanced squamous cell carcinomas of the head and neck. Thirteen patients with recurrent, metastatic, or high-risk (defined as an expected 2-year survival rate of <10%) head and neck cancer were enrolled and treated with concomitant chemoradiotherapy on an every-other-week schedule. Eniluracil at a fixed dose [20 mg twice a day (BID)] was given for 7 consecutive days (days 1-7). 5-FU and RT were given on 5 consecutive days (days 2-6). One patient was treated with once-daily RT (2.0 Gy fractions). The remaining patients received hyperfractionated RT (1.5-Gy fractions BID). The initial dose of 5-FU was 2.5 mg/m2 given BID. Dose escalation in patient cohorts was scheduled at 2.5-mg/m2 increments, with intrapatient dose escalation permitted. Lymphocyte DPD activity and serum 5-FU and uracil concentrations were monitored during two cycles. DPD activity was completely or nearly completely inactivated in all patients. Sustained, presumed therapeutic concentrations of 5-FU were observed at a dose of 5.0 mg/m2 given BID. Cumulative dose-limiting myelosuppression (both neutropenia and thrombocytopenia) was observed during the fourth and fifth cycles following administration of 5.0 mg/m2 5-FU BID. One patient died of neutropenic sepsis during cycle 4. Other late cycle toxicities included diarrhea, fatigue, and mucositis. Grade 3 mucositis was observed in 4 patients, but no grade 4 mucositis or grade 3 or 4 dermatitis was observed. A second patient death occurred during cycle 1 of treatment. No specific cause of death was identified. The study was subsequently discontinued. Cumulative myelosupression was the significant dose-limiting toxicity of oral 5-FU given with the DPD-inactivator eniluracil on an every-other-week schedule. Clinical radiation sensitization was not observed, based on the absence of dose-limiting mucositis and dermatitis. Alternative dosing schedules need to be examined to determine the most appropriate use of eniluracil and 5-FU as radiation enhancers.  (+info)

Clinical significance of decreased zeta chain expression in peripheral blood lymphocytes of patients with head and neck cancer. (4/5027)

Patients with squamous cell carcinoma of the head and neck (SCCHN) frequently have impaired immune responses. Alterations in T-cell receptor-associated signaling molecules in tumor-infiltrating as well as circulating lymphocytes have been reported in these patients. Using quantitative flow cytometry analysis, we have demonstrated that expression of the zeta chain is significantly decreased relative to normal controls in both CD8+ and CD4+ T cells as well as CD3- CD56+ CD16+ natural killer cells in the peripheral blood of patients with SCCHN who, as a result of previous therapies, have no evident disease. Patients with a more aggressive type of SCCHN and those who experienced a recurrence or had a second primary cancer within the last 2 years of the study had the lowest zeta chain expression. In addition, SCCHN patients showed a significantly greater spontaneous ex vivo apoptosis, as measured by a terminal deoxynucleotide transferase-mediated dUTP nick end labeling assay, in PBMCs, compared to normal controls. The observed decreased expression of zeta in T and natural killer cells coincided but did not directly correlate with significantly increased spontaneous apoptosis of lymphocytes obtained from treated patients with no evident disease. The results suggest that in patients with SCCHN, zeta chain defects and lymphocyte apoptosis are manifestations of long-lasting negative effects of tumor on the immune system.  (+info)

Expression of apoptosis-related genes in human head and neck squamous cell carcinomas undergoing p53-mediated programmed cell death. (5/5027)

Human head and neck squamous cell carcinoma (HNSCC) lines infected with a replication-defective Ad5CMV-p53 vector bearing a wild-type human p53 gene were used to examine alterations in the production of proteins implicated in regulating apoptosis. Because HNSCC lines express abundant levels of c-myc, and simultaneous expression of c-myc and p53 is known to trigger apoptosis in other cells, cooperation between these two genes was examined. Surprisingly, levels of c-myc mRNA and protein were rapidly and profoundly suppressed after infection with wild-type p53. Suppression of c-myc using antisense oligodeoxynucleotides (in the absence of p53) was sufficient to trigger apoptosis in Tu-138 cells, raising the possibility that the reduction of c-myc may be involved in at least one of the cell death pathways mediated by p53. Expression of a panel of Bcl-2 homology proteins was also examined in HNSCC lines undergoing p53-mediated apoptosis. No changes in Bcl-2, Bak, or Bcl-xS were found after p53 expression. Increased levels of the apoptosis-accelerating protein Bax were found in HNSCC lines after infection with Ad5CMV-p53. Induction of the apoptosis-inhibiting protein Bcl-xL was observed in Tu-167 cells and may account for the delayed onset of apoptosis in these cells. These studies suggest that multiple pathways may regulate apoptosis after transient overexpression of p53.  (+info)

The contribution of DNA ploidy to radiation sensitivity in human tumour cell lines. (6/5027)

The contribution of DNA ploidy to radiation sensitivity was investigated in a group of eight human tumour cell lines. As previous studies suggest, while more aneuploid tumours tend to be more radioresistant, there is no significant relationship between ploidy and radiation sensitivity (SF2). The failure to observe a significant effect of ploidy on radiation sensitivity is due to the complex and multifactorial basis of radiation sensitivity. When we determined the relationship between survival and radiation-induced chromosome aberration frequency, a measure independent of most other modifiers of sensitivity, we observed a direct relationship between ploidy and mean lethal aberration frequency. The mean lethal frequency of aberrations increased from about 1 for diploid cells to about 2 for tetraploid cells. The mean lethal frequency of aberrations was independent of DNA repair variations. These observations demonstrate that changes in DNA ploidy are an important contributor to radiation sensitivity variations in human tumour cell lines. Therefore, any battery of predictive assays should include DNA ploidy measurements.  (+info)

Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. (7/5027)

The purpose of this study was to determine whether cyclooxygenase-2 (COX-2) was overexpressed in squamous cell carcinoma of the head and neck (HNSCC). Quantitative reverse transcription-PCR, immunoblotting, and immunohistochemistry were used to assess the expression of COX-2 in head and neck tissue. Mean levels of COX-2 mRNA were increased by nearly 150-fold in HNSCC (n = 24) compared with normal oral mucosa from healthy volunteers (n = 17). Additionally, there was about a 50-fold increase in amounts of COX-2 mRNA in normal-appearing epithelium adjacent to HNSCC (n = 10) compared with normal oral mucosa from healthy volunteers. Immunoblotting demonstrated that COX-2 protein was present in six of six cases of HNSCC but was undetectable in normal oral mucosa from healthy subjects. Immunohistochemical analysis showed that COX-2 was expressed in both HNSCC and adjacent normal-appearing epithelium. Taken together, these results suggest that COX-2 may be a target for the prevention or treatment of HNSCC.  (+info)

Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35. (8/5027)

PURPOSE: The aim of this study was to define the scales and test the validity, reliability, and sensitivity of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-H&N35, a questionnaire designed to assess the quality of life of head and neck (H&N) cancer patients in conjunction with the general cancer-specific EORTC QLQ-C30. PATIENTS AND METHODS: Questionnaires were given to 500 H&N cancer patients from Norway, Sweden, and the Netherlands as part of two prospective studies. The patients completed the questionnaires before, during (Norway and Sweden only), and after treatment, yielding a total of 2070 completed questionnaires. RESULTS: The compliance rate was high, and the questionnaires were well accepted by the patients. Seven scales were constructed (pain, swallowing, senses, speech, social eating, social contact, sexuality). Scales and single items were sensitive to differences between patient subgroups with relation to site, stage, or performance status. Most scales and single items were sensitive to changes, with differences of various magnitudes according to the site in question. The internal consistency, as assessed by Cronbach's alpha coefficient, varied according to assessment point and within subsamples of patients. A low overall alpha value was found for the speech and the senses scales, but values were higher in assessments of patients with laryngeal cancer and in patients with nose, sinus, and salivary gland tumors. Scales and single items in the QLQ-H&N35 seem to be more sensitive to differences between groups and changes over time than do the scales and single items in the core questionnaire. CONCLUSION: The QLQ-H&N35, in conjunction with the QLQ-C30, provides a valuable tool for the assessment of health-related quality of life in clinical studies of H&N cancer patients before, during, and after treatment with radiotherapy, surgery, or chemotherapy.  (+info)

On World Head and Neck Cancer Day held on July 27, the experts urged Indian citizens to stay away from tobacco use, as its a major cause of cancer. Head and neck cancer occurs mainly in the mouth, larynx, throat or nose.. Dr. Harit Chaturvedi, cancer surgeon, Chairman Max Oncology, and Voice of Tobacco Victims (VoTV) patron said, Head & neck cancers are the biggest sources of the cancer burden in India. Nearly half of the newly diagnosed head & neck cancers die within 12 months of diagnosis. Paradoxically, two-thirds of head & neck cancers are related to known agents such as tobacco, areca nut, and alcohol.. Unfortunately, these causative agents are freely available either due to a weak policy implementation or absence of it. India witnesses 1.75 lac new cases of head and neck cancers every year. Of these 76% are males and 24% are females.. In India, tobacco chewing is more as compared to smoking. According to the Global Adult Tobacco Survey 2017, of the 28.6% of overall prevalence of ...
TY - JOUR. T1 - Cisplatin and 5-fluorouracil as neoadjuvant chemotherapy. T2 - Predicting response in head and neck squamous cell cancer. AU - Wang, H. M.. AU - Wang, C. H.. AU - Chen, J. S.. AU - Chang, H. K.. AU - Kiu, M. C.. AU - Liaw, C. C.. AU - Ng, K. T.. AU - Lai, G. M.. PY - 1995. Y1 - 1995. N2 - In order to prospectively evaluate the efficacy, toxicity and predictive factors of response to neoadjuvant chemotherapy, a total of 120 patients with head and neck squamous cell cancer diagnosed from January 1992 to November 1993 were enrolled in this study. There were 118 male and 2 female patients, with a median age of 51 years (range 30-74 years). The primary sites were the oral cavity (77), oropharynx (15), hypopharynx (25) and larynx (3). Betel quid chewing was habitual in 91% of patients. All patients were previously untreated, and 94% had stage III or IV disease. Chemotherapy was given in two or three courses to 96 patients who were then assessed for response rate and predictive factors. ...
Radiation therapy for head and neck neoplasms , Radiation therapy for head and neck neoplasms , کتابخانه دیجیتال دانشگاه علوم پزشکی اصفهان
Clinical trial for Cancer/Tumors | Ewings Family Tumors | head and neck cancer | Head and Neck Cancer Metastatic | Head and Neck Carcinoma | Cancer (Pediatric) | Oral Neoplasm | Esophageal Cancer | Oral Cavity Cancer | Cancer Metastatic | Head and Neck Cancer Stage IV | Oral Cancer | Cancer | Head and Neck Cancer Stage III | Esophageal Diseases | Head and Neck Squamous Cell Carcinoma | Esophageal Disorders | Neoplasms , Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer
Treatment with the immune-stimulating agent, Keytruda® (pembrolizumab), provides impressive long-term outcomes for some patients with metastatic or recurrent head and neck cancer. These results were recently presented at the 2016 annual meeting of the American Society of Clinical Oncology (ASCO).. Globally, head and neck cancer comprises the seventh most common type of cancer with an estimated 400,000-600,000 diagnoses every year. Head and neck squamous cell cancer (HNSCC) refers to head and neck cancer that originates in certain cells called squamous cells.. Metastatic or stage IV head and neck cancer refers to cancer that has spread from its site of origin to distant sites in the body. Overall survival at 5 years for patients diagnosed with metastatic head and neck cancer has remained at less than 4%, indicating a significant need in improved treatment for patients with this disease. Recurrent head and neck cancer refers to cancer that has recurred or progressed despite prior ...
Table 2: The Diagnostic Value of Cervical Lymph Node Metastasis in Head and Neck Squamous Carcinoma by Using Diffusion-Weighted Magnetic Resonance Imaging and Computed Tomography Perfusion
What is head/neck cancer? It is any type of cancer that originates in the cranial sinuses, the mouth, or the throat. It does not include brain tumors or thyroid tumors. Why do we need a month of awareness for this type of cancer? Head/neck cancer (HNC) is not well known. It counts for about 3-5% of all new cancer diagnoses in the USA each year. Or, about 81,000 people each year. In the big picture of things this is considered an inconsequential number of people affected. But, the effects of the cancer and the treatment to eradicate the treatment has a most consequential impact on those 81,000 people every year.. 10 years ago I was at the height of my professional career. I was on a business trip and after a late meal felt a lump in my throat. When I photographed my throat I could see the lump was a big, ugly, red, yellow and white mass. As I was working for a CT scanner manufacturer, after my meeting next day I visited the engineering bay and asked the guys to scan my neck. I programmed the ...
Read about Narrow Band Imaging (NBI), a new endoscopic, diagnostic technique for detection of Head & neck cancer in aerodigestive tract, provided at Sakra world Hospital.
Clinical trial for Locally Recurrent Head and Neck Squamous Cell Carcinoma | Recurrent Head and Neck Squamous Cell Carcinoma , Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma
A Multidisciplinary Approach to Head and Neck Neoplasms is a comprehensive how-to guide that addresses the medical and surgical treatment of the most common and challenging neoplasms in head and neck surgery. It takes a hands-on approach to describing the latest surgical techniques, including intraoperative navigation, robotic surgery, image guidance for sinus tumors, and endoscopic skull base procedures. This book will be the reference of choice for residents and fellows, experienced otolaryngologists, and head and neck surgeons ...
Most types of head and neck cancer develop in the lining of cells found within many parts of the head and neck. Each year, more than 40,000 adults are diagnosed with head and neck cancer in the United States. The leading cause of this type of cancer is tobacco use. Common signs and symptoms of head and neck cancer include blood in saliva; frequent nose bleeds; and difficulty chewing, swallowing, or breathing. Effective treatments for head and neck cancer are available if the cancer is found in its early stages. However, treatment is difficult, causing many people to become depressed within 3 months of being diagnosed. Unfortunately, depression can lead to delays in treatment, impair quality of life, and decrease long-term survival. The purpose of this study is to determine whether the use of antidepressant medication initiated prior to starting treatment will prevent the onset of depression during treatment in non-depressed head and neck cancer patients. This study will also determine if ...
Introduction. Worldwide, more than 550,000 cases and 380,000 deaths occur annually from head and neck squamous cell carcinoma (HNSCC).1 In the United States, 63,000 patients are diagnosed annually, and about 13,000 die from the disease.2 The majority are related to tobacco and alcohol use, but the number of high-risk human papillomavirus (HPV)-associated oropharynx cancers is increasing; these are often identified in clinical trials via staining for the surrogate marker p16. Tumors that are p16-positive (+) have a more favorable prognosis and may require less intense treatment.3,4. Patients with HPV-associated cancers are significantly younger, have tumors typically in the tonsillar region or base of tongue, and tend to present with early-stage primary tumors with an increased risk of advanced nodal involvement when compared with HPV-negative (-) patients.5 HPV-associated tumors are pathologically distinct, with lymphocyte infiltration in the stroma and in tumor nests.6 Despite advances in ...
Background: Neurobehavioral functions and quality of life (QoL) are the important outcome measurements after radiotherapy in patients with brain tumors and even head/neck cancers. However, few studies have focused on neurobehavioral functions and QoL after anti-cancer treatment particularly brain radiotherapy for pediatric/adolescent patients with brain tumors. This study thus aims to prospectively evaluate those functions in pediatric or adolescent patients with brain or head/neck tumors in order to provide useful information about their clinical outcomes.. Methods: A total of 72 pediatric/adolescent patients, who are diagnosed with brain tumors or head/neck cancers, were prospectively recruited. Neurobehavioral functions will be evaluated using a neuropsychological battery, which includes general cognitive functions, intelligence, memory, executive functions, information processing and emotional/behavioral expressions. The QoL will be evaluated by the health-related QoL questionnaire. All ...
TY - JOUR. T1 - Non-squamous variants of human papillomavirus-related head and neck carcinoma. AU - Bishop, Justin A.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Human papillomavirus (HPV) is now well established as an important causative agent in a subset of head and neck cancers. HPV-related head and neck carcinomas are important to recognize because these malignancies are associated with better survival and an improved response to therapy when compared to their HPV-negative counterparts. HPV-related head and neck cancer characteristically takes the form of a non-keratinizing squamous cell carcinoma. Widespread HPV testing of head and neck tumours, however, has revealed variants that depart from the standard HPV-related squamous cell carcinoma morphology. Most recently, examples of HPV-related carcinomas that actually lack a squamous phenotype, at least partially, have been reported. This manuscript will discuss these non-squamous variants of HPV-related head and neck carcinomas: adenosquamous ...
The ENT Center of Utahs Head & Neck Surgeons specialize in Head & Neck Cancer. Contact the ENT Center of Utah today, with locations across the Salt Lake Valley.
(HealthDay)-Twenty-three percent of patients with head and neck squamous cell carcinoma (HNSCC) have cardiovascular disease (CVD) at diagnosis, and 24 percent have uncontrolled blood pressure, according to research published ...
Circulating interleukin-6 (IL-6) improves outcome prediction for second primary cancer (SPC) in head and neck cancer (HNC) patients. This study aimed to identify factors associated with IL-6 serum levels in HNC patients. This study was conducted as part of a phase III chemoprevention trial. IL-6 was measured using chemiluminescent immunometric assay on pretreatment serum sample obtained from 527 stage I-II HNC patients. Patients lifestyle habits, sociodemographic, medical and tumor characteristics were evaluated before radiation therapy (RT). Factors independently associated with IL-6 levels before RT were identified using multiple linear regression. The median IL-6 serum level was 3.1 ng/L. In the multivariate analysis, eight factors were significantly associated (p | 0.05) with IL-6: age, gender, marital status, body mass index, tobacco consumption, comorbidities, Karnofsky Performance Status and HNC site. Smoking duration and lifetime pack-years were positively associated with IL-6 serum levels in
Cherubism is a rare benign (non-neoplastic) hereditary condition of childhood, which is inherited as an autosomal dominant trait and is characterized by bilateral expansion of the mandible, maxilla or both. Giving them a characteristic cherubic appearance. The treatment of cherubism is still controversial and is said that the disease regresses itself and after regressing if any asymmetry is left then the bony deformity can be corrected by decortications of bone and osseous shaving. This article reviews the recent development in the literature of cherubism ...
Every cancer has a color. The color Burgundy represents Multiple Myeloma and Head + Neck Cancer. When you wear this bracelet symbolizing everything that Cancer Canknot do, we will donate 20% of your purchase price to cancer research. This bracelet comes in multiple sizes to fit your entire family. Child: fits wrists 4-
Head and neck cancers are a group of biologically similar cancers originating from the upper aerodigestive tract, including the lip, mouth, nasal cavity, paranasal sinuses, pharynx and larynx that affect more than 45,000 individuals in the U.S. each year. Head and neck cancers are strongly associated with environmental and lifestyle risk factors, including tobacco smoking, alcohol consumption and certain strains of the sexually transmitted human papilloma virus.. Founded in 1984, the University of Pittsburgh Cancer Institute became a National Cancer Institute (NCI)-designated Comprehensive Cancer Center in six years. UPCI is the only cancer center in western Pennsylvania with this elite designation, serving the regions population of more than 6 million. Presently, UPCI receives a total of $154 million in research grants and is ranked 10th in NCI funding.. ...
Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. However, drug-resistance interferes with the effectiveness of chemotherapy. Preclinical testing models are needed in order to develop approaches to overcome chemoresistance. Ten human cell lines were obtained from HNSCC, including one with experimentally-induced cisplatin resistance. Inhibition of cell growth by seven chemotherapeutic agents (cisplatin, carboplatin, 5- fluorouracil, methotrexate, bleomycin, vincristin, and paclitaxel) was measured using metabolic MTT-uptake assay and correlated to clinically-achievable plasma concentrations. All drugs inhibited cell growth in a concentration-dependent manner with an IC50 comparable to that achievable in vivo. However, response curves for methotrexate were unsatisfactory and for paclitaxel, the solubilizer cremophor EL was toxic. Cross-resistance was observed between cisplatin and carboplatin. Chemosensitivity of HNSCC cell lines can be
Exposure to tobacco-specific nitrosamines (TSNA) and polycyclic aromatic hydrocarbons (PAH) is recognized to play an important role in the development of oral/head and neck squamous cell cancer (HNSCC). We recently reported higher levels of TSNA-associated DNA adducts in the oral cells of smokers with HNSCC as compared with cancer-free smokers. In this study, we further investigated the tobacco constituent exposures in the same smokers to better understand the potential causes for the elevated oral DNA damage in smokers with HNSCC. Subjects included cigarette smokers with HNSCC (cases, n = 30) and cancer-free smokers (controls, n = 35). At recruitment, tobacco/alcohol use questionnaires were completed, and urine and oral cell samples were obtained. Analysis of urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and N-Nitrosonornicotine (NNN; TSNA biomarkers), 1-hydroxypyrene (1-HOP, a PAH), cotinine, 3′-hydroxycotinine, and the nicotine metabolite ratio (NMR) were performed. Cases ...
#7219 Head and Neck Cancer: Issues Related to Speech and Swallowing The purpose of this course is to provide a knowledge base on the diagnosis of dysphagia and speech deficits and treatment strategies including use of tracheoesophageal prosthesis (TEP) for individuals diagnosed with head and neck cancers. Characteristics and functional impact of head and neck lymphedema on speech, swallowing and quality of life will be reviewed. The importance of a multi-disciplinary team approach in the treatment of head and neck cancer will also be discussed. (Introductory Level) Instructor: Catherine C. Crowley, Ph.D, CCC-SLP and Kristin Beadle, M.S., CCC-SLP, CLT Live Webinar Dates and Times:No dates scheduled at this time
The official journal of the Head & Neck Optical Diagnostics Society. Head & Neck Oncology encompasses all aspects of clinical practice, basic and ...
Every year, more than 17,000 people in Germany are diagnosed with head and neck cancers. These include cancers of the oral cavity, larynx and nose, but can also affect other areas of the head and neck. Some head and neck cancer patients will also develop lung cancer. In the large majority of cases, it is impossible to determine whether these represent pulmonary metastases of the patients head and neck cancer or a second primary cancer, i.e. primary lung cancer, explains Prof. Dr. Frederick Klauschen of Charités Institute of Pathology, who co-led the study alongside Prof. Dr. David Capper of Charités Department of Neuropathology. This distinction is hugely important in the treatment of people affected by these cancers, emphasizes Prof. Klauschen, adding: While surgery may provide a cure in patients with localized lung cancers, patients with metastatic head and neck cancers fare significantly worse in terms of survival and will require treatments such as chemoradiotherapy ...
Oral, Head and Neck Oncology and Reconstructive Surgery is the first multidisciplinary text to provide readers with a system for managing adult head and neck cancers based upon stage. Using an evidence-based approach to the management and treatment of a wide variety of clinical conditions, the extensive experience of the author and contributors in head and neck surgery and oncology are highlighted throughout the text. This includes computer aided surgical simulation, intraoperative navigation, robotic surgery, endoscopic surgery, microvascular reconstructive surgery, molecular science, and tumor immunology. In addition, high quality photos and illustrations are included, which are easily accessible on mobile devices.
GSH and transcription factor NF-alphaB can contribute independently to cisplatin and radiation sensitivity of human HNSCC. These results highlight the need to define molecular determinants of chemotherapy and radiation sensitivity for use in the selection of patients and as novel targets for therapy …
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PURPOSE: Mitochondrial dysfunction has been linked to defects in the apoptotic pathway, and solid tumors, including head and neck squamous cell carcinoma (HNSCC), exhibit defects in apoptosis. Loss of mitochondrial membrane potential (DeltaPsim) is a
Head and neck cancer is a group of cancers that starts within the mouth, nose, throat, larynx, sinuses, or salivary glands. Symptoms may include a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in the voice. There may also be unusual bleeding, facial swelling, or trouble breathing. About 75% of head and neck cancer is due to the use of alcohol or tobacco. Other risk factors include betel quid, certain types of human papillomavirus, radiation exposure, certain workplace exposures, and Epstein-Barr virus. Head and neck cancers are most commonly of the squamous cell carcinoma type. The diagnosis is confirmed by tissue biopsy. The degree of spread may be determined by medical imaging and blood tests. Not using tobacco or alcohol can reduce the risk. While screening in the general population does not appear to be useful, screening high risk groups by examination of the throat might be useful. Often, head and neck cancer is curable if detected ...
Conference report on the Indo Global Summit on Head and Neck Oncology (IGSHNO 2017-BMCON-IV), 24-26 February 2017, Jaipur, India Tej Prakash Soni,
Decisions about treatment for head and neck cancer are largely dependent on the site, stage, and histological characteristics of the disease. Treatment may include surgery, RT, chemotherapy, or some combination of these. RT is offered to nearly 75 percent of patients with head and neck cancer with curative or palliative intent, often with long-term side effects.. RT techniques have evolved over the past 30 years; two-dimensional images have been replaced with three-dimensional (3D) images with the intended purpose of improving effectiveness while reducing toxicity to normal tissues and adjacent vulnerable organs. Photon-based conformal external-beam RT modalities used to treat head and neck cancer include 3D conformal RT (3DCRT), intensity-modulated RT (IMRT), and stereotactic body RT (SBRT). Charged particle-based conformal external-beam RT modalities, such as proton-beam RT (PBT), are also available to treat head and neck cancer, although they are not widely available in the United ...
Objective: Head and Neck Squamous Cell Carcinoma (HNSCC) is the fifth most common cancer worldwide with five-year survival rate of 50% despite use of modern treatment modalities. We have employed a comprehensive genome-wide integrated analysis of epigenetic and transcriptional alteration in primary HNSCC tissues in order to discover novel biomarkers of this disease.. Experimental Design: A discovery cohort included 44 primary HNSCC and 25 normal mucosal samples was analyzed by Affymetrix GeneChip Human Exon 1.0 and Illumina Infinium Human Methylation 27 arrays. An independent validation cohort included 32 primary HNSCC and 15 normal mucosal samples to confirm differential methylation by bisulfate sequencing. A second validation cohort included salivary rinse and primary tissue from 59 HNSCC and 31 healthy patients. Detection of DNA methylation in bodily fluids and primary tissues from the later cohort was evaluated by quantitative methylation-specific PCR (qMSP).. Results: We have applied novel ...
Background: An association between sexually transmitted diseases (STDs) and occurrence of head and neck cancer (HNC) is proposed.Aims/objectives: We aimed to determine the association between selected STDs (syphilis, gonorrhoea, HIV) and HNC.Materials and methods: Patients diagnosed with HNC in Denmark between 1978 and 2014 identified through the Danish Cancer Registry were included. Patients were age- and sex-matched in a 1:10 ratio with general population controls. Uni- and multivariate analyses were performed using the Cox regression model to assess the correlation between STD and HNC.Results: A total of 39,405 HNC patients (63% men; 63.0 years at HNC diagnosis) and 393,238 controls were included. STD in HNC patients was 0.27%, vs. 0.11% in controls. Patients with cancer of the upper airways had a significantly higher prevalence of an STD prior to the HNC compared to controls. Most HNC patients with a prior STD (64.1%) developed the HNC within five years after the STD diagnosis.Conclusions: ...
(580) 421-6470 | Head and neck cancers are those that grow in and around the throat, larynx, nose, sinuses and mouth. The majority of these cancers are squamous cell
The two strongest risk factors for these cancers are excessive alcohol use and tobacco use. At least 75 percent of head and neck cancers are related to alcohol and tobacco use, and people who drink excessively and use tobacco - whether smoked or chewed - are at even greater risk than those who use either tobacco or alcohol alone. ...
TY - JOUR. T1 - Role of twist in head and neck carcinoma with lymph node metastasis. AU - Ou, Da Liang. AU - Chien, Hsiung Fei. AU - Chen, Chi Long. AU - Lin, Tsung Chin. AU - Lin, Liang In. PY - 2008/3. Y1 - 2008/3. N2 - The transcription factor Twist protein has been found to be correlated with metastasis in various carcinomas, including hepatocellular, breast and prostate carcinomas. However, the role of Twist in head and neck squamous cell carcinomas (HNSCC) remains unknown. Head and neck cancer tissue microarrays (TMAs) of tumors from 50 patients with HNSCC were examined. Immunohistochemical (IHC) stain analysis showed that, out of the 50 patients, twenty (40%) showed Twist-positive staining in the tumor cells, and Twist expression was positively associated with differentiation status (p=0.027), lymph node metastasis (p=0.032) and disease progression (p=0.029). Further analysis revealed that the expression of Twist was positively correlated with CXCR4 (Spearman, r=0.408, p=0.003) and CCR7 ...
The biggest risk factors for head and neck cancers are tobacco (both cigarettes and chewing tobacco) and alcohol, especially when used together.
Tumors of the head and neck present aggressive pathological behavior in patients due to high expression of CDK/CCND1 proteins. P276-00, a novel CDK inhibitor currently being tested in clinic, inhibits growth of several cancers in vitro and in vivo. The pre clinical activity of P276-00 in head and neck cancer and its potential mechanisms of action at molecular level are the focus of the current studies. We have investigated the anti-cancer activity of P276-00 in head and neck tumors in vitro and in vivo. Candidate gene expression profiling and cell based proteomic approaches were taken to understand the pathways affected by P276-00 treatment. It was observed that P276-00 is cytotoxic across various HNSCC cell lines with an IC50 ranging from 1.0-1.5 μmoles/L and culminated in significant cell-cycle arrest in G1/S phase followed by apoptosis. P276-00 treatment suppressed cell proliferation through inhibition of CCND1 expression, reduced phosphorylation of retinoblastoma protein and abrogative
Squamous cell carcinoma of the head and neck (SCCHN) cells can escape recognition and lysis by tumor antigen (TA)-specific cytotoxic T lymphocytes (CTL) by downregulation of antigen processing machinery (APM) components, such as the transporter associated with antigen processing (TAP)-1/2 heterodimer. APM component upregulation by interferon gamma (IFN-g) restores SCCHN cell susceptibility to lysis by CTL, but the mechanism underlying TAP1/2 downregulation in SCCHN cells is not known. Because IFN-g activates signal transducer and activator of transcription (STAT)-1, we investigated phosphorylated (p)-STAT1 as a mediator of low basal TAP1/2 expression in SCCHN cells. SCCHN cells were found to express basal total STAT1 but low to undetectable levels of pSTAT1. The association of increased pSTAT1 levels and APM components likely reflects a cause-effect relationship, since STAT1 knockdown significantly reduced both IFN-g-mediated APM component expression and TA-specific CTL recognition of IFN-g ...
Welcome to the Head and Neck Cancer group. This is a welcoming, safe place where you can meet other people who are living with head and neck cancer. Lets learn from each other and share experiences from diagnosis through treatment and coping with symptoms and recovery challenges. Im Colleen, […]
According to an article recently published in the Archives of Otolargynology - Head and Neck Surgery, patients with head and neck cancer who are undergoing chemotherapy and radiation therapy have high rates of impaired ability to swallow, causing them to suck food or liquid particles through their vocal cords (aspiration).. Head and neck cancers originate in the oral cavity (lip, mouth, and tongue), salivary glands, paranasal sinuses, and nasal cavity, pharynx (upper back part of the throat), larynx (voice box), and lymph nodes in the upper part of the neck. Worldwide, head and neck cancer is diagnosed in approximately 640,000 people annually and is responsible for approximately 350,000 deaths each year.. Chemotherapy and radiation therapy are common treatment approaches for patients with head and neck cancer. These treatments are, however, associated with side effects, some of which impair ability to swallow. When swallowing is impaired, there is a risk of aspiration, often thought of as food ...
First-line treatment with Keytruda significantly prolongs survival of patients with recurrent or metastatic head and neck squamous cell carcinoma
Head and neck cancer refers to tumors that occur in the lining of the nose, mouth (oral cancer) or throat, as well as cancers of the thyroid, parathyroid and salivary glands. Doctors also include advanced skin cancers of the head and neck (scalp, ears, face and neck) in this category of cancers. ...
Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression clustered with the expression of 10 well-known hypoxia-regulated genes (e.g., CA9, GLUT1, and VEGF). To minimize random aggregation, strongly correlated up-regulated genes appearing in |50% of clusters defined a signature comprising 99 genes, of which 27% were previously known to be hypoxia associated. The median RNA expression of the 99 genes in the signature was an independent prognostic factor for recurrence-free survival in a publicly available head and neck cancer data set, outdoing the original intrinsic classifier. In a published breast cancer series, the hypoxia signature was a significant prognostic factor for overall survival independent of clinicopathologic risk factors and a trained profile. The work highlights the validity and potential of using data from analysis of in vitro stress pathways for deriving a biological
Exosomes Derived from Squamous Head and Neck Cancer Promote Cell Survival after Ionizing Radiation. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. AU - Kang, Sumin. AU - Elf, Shannon. AU - Lythgoe, Katherine. AU - Hitosugi, Taro. AU - Taunton, Jack. AU - Zhou, Wei. AU - Xiong, Li. AU - Wang, Dongsheng. AU - Muller, Susan. AU - Fan, Songqing. AU - Sun, Shi Yong. AU - Marcus, Adam I.. AU - Gu, Ting Lei. AU - Polakiewicz, Roberto D.. AU - Chen, Zhuo. AU - Khuri, Fadlo R.. AU - Shin, Dong M.. AU - Chen, Jing. PY - 2010/4/1. Y1 - 2010/4/1. N2 - Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer and frequently metastasizes to LNs. Identifying metastasis-promoting factors is of immense clinical interest, as the prognosis for patients with even a single unilateral LN metastasis is extremely poor. Here, we report that p90 ribosomal S6 kinase 2 (RSK2) promotes human HNSCC cell invasion and metastasis. We determined that RSK2 was overexpressed and activated in highly invasive HNSCC ...
Two phase III clinical trials (CheckMate 141 and KEYNOTE 040) have independently demonstrated that overall survival (OS) in recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients, who have failed platinum-based therapy, can be improved with anti-PD1 monotherapy. Treatment with nivolumab or pembrolizumab in R/M HNSCC patients led to an improved OS with a hazards ratio (HR) of 0.70 (95%CI 0.51-0.96; p = 0.01) and HR of 0.80 (95%CI 0.65-0.98, p = 0.0161), respectively, as compared to standard of care (SOC) chemo monotherapy regimens (specifically, cetuximab, docetaxel, or methotrexate). The gain in OS was similar in both studies, underscoring the role of anti-PD1 drugs in R/M HNSCC patients. One of the striking discrepancies between CheckMate 141 and KEYNOTE 040 was the OS observed in the control SOC arms (6.9 months median in KEYNOTE 040 versus 5.1 months in CheckMate 141), which inadvertently set a higher threshold in the bio-statistical analysis of KEYNOTE 040 so that the
Pathology Department, Harvard Medical School, Boston, Massachusetts 02115-5701, USA. We have investigated the functional integrity of the retinoblastoma tumor suppressor pathway in five human squamous cell carcinoma lines. Elevated activity of cyclin-dependent kinase 6 (cdk6), a pRB kinase, was detected in all five squamous cell carcinoma lines. Overexpression of the cdk6 protein was detected in one of the five cell lines. The cdk6-specific inhibitor p18ink4C is expressed and associated with cdk6 in all five squamous cell carcinoma lines. In contrast, only very low levels of p16ink4A were detected in these cell lines. This may contribute to the elevated activity of cdk6 in these lines. Elevated activity of cdk6 may result in hyperphosphorylation of the retinoblastoma protein and, therefore, compromise its negative growth-regulatory activity ...
Semantic Scholar extracted view of Head and neck squamous cell carcinoma cell lines as a model system for the study of oncogene expression during tumor progression and metastasis. by Gary Edward Gallick et al.
TY - JOUR. T1 - Primary Head and Neck Cancer. T2 - Histopathologic Predictors of Recurrence After Neck Dissection in Patients With Lymph Node Involvement. AU - Olsen, Kerry D.. AU - Caruso, Michela. AU - Foote, Robert L.. AU - Stanley, Robert J.. AU - Lewis, Jean E.. AU - Buskirk, Steven J.. AU - Frassica, Deborah A.. AU - Desanto, Lawrence W.. AU - Ofallon, W. Michael. AU - Hoverman, Verna R.. PY - 1994/12. Y1 - 1994/12. N2 - Objective: Retrospectively analyze several histopathologic variables that may predict neck recurrence after neck dissection. Design: From 1970 through 1980, 284 patients with pathologically confirmed metastatic squamous cell carcinoma underwent neck dissection and received no adjuvant therapy. Kaplan-Meier evaluation estimated a 74% 2-year neck recurrence-free rate. After adjusting for the standard covariates of age, gender, neck stage, and tumor grade, we also controlled for the time-dependent co-variates of primary recurrence, occurrence in the side of the neck not ...
Reactive oxygen species (ROS) produced as a part of cellular metabolism can interact with biological macromolecules such as DNA, proteins and lipids and interfere with their normal functions, leading to the loss of cellular viability. ROS have been implicated in many pathophysiological conditions including cancer. In the present study, the damage caused by ROS and the effect of radiation in head and neck squamous cell carcinoma (HNSCC) patients were assessed in the erythrocytes by analyzing the superoxide dismutase (SOD) and catalase (CAT) activities, and levels of total thiols (T-SH) and malondialdehyde (MDA, a marker for lipid peroxidation). Blood samples were collected before the start of treatment and after the completion of radiotherapy. Both SOD and CAT activities were decreased in untreated patients, but elevated in patients after treatment. The T-SH levels were also depleted in untreated HNSCC patients, but elevated non-significantly after radiation therapy (p>0.05). The levels of MDA ...
Recurrent squamous cell carcinoma of the skin treated successfully with single agent cetuximab therapy Selcuk Seber,1 Aylin Gonultas,2 Ozlem Ozturk,2 Tarkan Yetisyigit1 1Department of Medical Oncology, Faculty of Medicine, Namik Kemal University, 2Pathology Department, Tekirdag State Hospital, Tekirdag, Turkey Abstract: Recurrent squamous cell carcinoma of the skin is a rare but difficult to treat condition. Frequently, the disease presents itself in elderly patients with poor performance status and bearing many comorbidities, thus the decision to administer systemic chemotherapy becomes difficult to make. In addition, current chemotherapeutic protocols response rates are far from satisfactory. Recently cetuximab, a chimeric antibody against epidermal growth factor receptor, is increasingly being reported as an alternative treatment. We therefore report this case of a recurrent squamous cell carcinoma of the skin in an elderly woman with poor performance status and who had an excellent clinical
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EDKINS, O; HOFMEYR, C and FAGAN, J J. Does sentinel lymph node biopsy have a role in node-positive head and neck squamous carcinoma?. S. Afr. j. surg. [online]. 2013, vol.51, n.1, pp.22-25. ISSN 2078-5151. http://dx.doi.org/10.7196/SAJS.1357.. OBJECTIVES/HYPOTHESIS: The objective of the study was to determine whether sentinel lymph node biopsy (SLNB) can be used to reduce clinical overstaging of cervical nodes in head and neck squamous cell carcinoma (SCC) in a developing world setting. STUDY DESIGN: Sentinel and echelon lymph nodes were identified by means of a combination of lymphoscintigraphy, gamma probe and blue dye staining. They were analysed histologically and their pathological status was compared with the rest of the neck dissection specimen to determine diagnostic accuracy in patients with T1-4 N0-3 SCC of the oral cavity or oropharynx undergoing primary surgical resection and neck dissection. RESULTS: Thirty-three patients were included in the study, 13 in the node-negative (N0) and ...
Fifty-two Head and Neck Cancer societies and forty-five countries have declared July 27 to be International Head and Neck Cancer Day. Head and neck cancer is the leading cause of cancer-related deaths and disability in many parts of the world. Head and neck cancers include mouth and throat cancer, thyroid, skin cancers of the head and neck and the new epidemic HPV-induced oropharynx cancers.. In support of International Head and Neck Cancer Day, The Dobleman Head and Neck Cancer Institute, will be raising awareness of these diseases by hosting a Golf-A-Thon. Our annual golf-a-thon is typically held the last week of July. Specific dates will be announced at the beginning of 2017. All proceeds from this event will be used for community-based prevention and early detection by providing free head and neck cancer screenings and education, CEU course for healthcare providers, a Creighton University IPE program for dental and medical students and research.. Golfers will play as many holes as they can, ...
article{ef10f59d-3cc7-4e16-a487-41c4d7d41751, abstract = {Introduction. Erythropoiesis-stimulating agents (ESAs) are used in cancer therapy to reverse anaemia. It has been suggested that ESAs might improve treatment outcome by reducing tumour hypoxia, but ESAs might also increase tumour growth. In this work, the effect of recombinant human erythropoietin (rHuEpo) beta was investigated on a human head and neck squamous carcinoma cell (HNSCC) line in vitro. The cell line was previously growth stimulated in combination with surgery in a xenograft model and the investigation was initiated to see if rHuEpo directly affects the tumour cell line, alone or in combination with cell stress, or if the in vivo effect should be attributed to secondary effects. Material and methods. The cell line LU-HNSCC-7 was grown in vitro and treated with rHuEpo alone or in combination with radiation, cisplatin, hypoxia or tumour extracts. The expression of the Epo receptor (EpoR) was investigated by western blotting ...
How is Head and Neck Squamous Cell Carcinoma abbreviated? H-NSCC stands for Head and Neck Squamous Cell Carcinoma. H-NSCC is defined as Head and Neck Squamous Cell Carcinoma rarely.
SCOTTSDALE, AZ--(Marketwired - February 20, 2014) - Evaluating next-generation sequencing (NGS) data and associated clinical records of head and neck squamous cell carcinoma (HNSCC) patients from several institutions, made available through The Cancer Genome Atlas (TCGA), showed that combining Mutant-Allele Tumor Heterogeneity (MATH) as a biomarker with the patients HPV...
Infection with high-risk types of human papilloma virus (HPV) is currently the best-established prognostic marker for head and neck squamous cell carcinoma (HNSCC), one of the most common and lethal human malignancies worldwide. Clinical trials have been launched to address the concept of treatment de-escalation for HPV-positive HNSCC with the final aim to reduce treatment related toxicity and debilitating long-term impacts on the quality of life. However, HPV-related tumors are mainly restricted to oropharyngeal SCC (OPSCC) and there is an urgent need to establish reliable biomarkers for all patients at high risk for treatment failure. A patient cohort (n = 295) with mainly non-OPSCC (72.9%) and a low prevalence of HPV16-related tumors (8.8%) was analyzed by MassARRAY to determine a previously established prognostic methylation score (MS). Kaplan-Meier revealed a highly significant correlation between a high MS and a favorable survival for OPSCC (P = 0.0004) and for non-OPSCC (P,0.0001), which ...
The immune landscape of head and neck squamous cell carcinoma in pretreated areas remains poorly documented. We aimed to assess the tumor microenvironment for biomarkers of antitumor immune responses in tumors in previously irradiated areas compared with de novo tumors. This retrospective monocentric study analyzed 100 paraffin‑embedded surgical samples of invasive head and neck squamous cell carcinoma (oral cavity, oropharynx, larynx, hypopharynx) from patients who underwent surgery between January 2010 and November 2017. We compared the immune microenvironment in 50 de novo tumors and 50 tumors recurring within irradiated areas. We used immunohistochemistry to assess p16 status, CD3+/CD8+ tumor‑infiltrating lymphocytes (TILs), and programmed death‑ligand 1 (PD‑L1) expression on tumor and immune cells in stromal and intratumoral components. CD3+ TIL counts were significantly lower in intratumoral and stromal components (P=0.003 and P=0.020, respectively) in the irradiated area cohort; ...
Background: Squamous cell carcinomas (SCCs) are common head and neck malignancies demonstrating lymph node LN involvement. Recently chemokine receptor overxpression has been reported in many cancers. Of particular interest, CCR7 appears to be a strong mediator of LN metastases, while CXCR4 may mediate distant metastases. Any relations between their expression in primary HNSCCs and metastatic lymph nodes need to be clarified. Aims: To investigate CCR7 andCXCR4 expression in primary HNSCCs of all tumor sizes, clinical stages and histological grades, as well as involved lymph nodes, then make comparisons, also with control normal oral epithelium. Materials and Methods: The sample consisted of 60 formalin-fixed, paraffin-embedded specimens of primary HNSCCs, 77 others of metastasi-positive lymph nodes, and 10 of control normal oral epithelial tissues. Sections were conventionally stained with H&E and immunohistochemically with monoclonal anti-CCR7 and monoclonal anti-CXCR4 antibodies. Positive cells were
TY - JOUR. T1 - Radioresistance in head and neck squamous cell carcinoma. T2 - Biological bases and therapeutic implications. AU - Perri, Francesco. AU - Pacelli, Roberto. AU - Della Vittoria Scarpati, Giuseppina. AU - Cella, Laura. AU - Giuliano, Mario. AU - Caponigro, Francesco. AU - Pepe, Stefano. PY - 2015/5/1. Y1 - 2015/5/1. N2 - Head and neck squamous cell carcinoma (HNSCC) is strongly associated with alcohol and tobacco consumption. Lately, the incidence of human papillomavirus (HPV)-related tumors has shown a significant increase, and HPV-related tumors show distinctive features if compared with the HPV-negative counterpart. Locally advanced HNSCC can be treated with concomitant chemoradiotherapy, but early recurrences sometimes occur. Relapses are often related to an intrinsic radioresistance of the tumors. Alterations in intracellular pathways, primarily involved in cell proliferation, apoptosis, and DNA repair, can lead to radioresistance. Preclinical and clinical evidence highlighted ...
Twenty-one head and neck squamous cell carcinoma (HNSCC) cell lines were established from 89 fresh tumor specimens in order to study the biology of HNSCC lines, establish tumors in nude mice, and evaluate the sensitivity to immunological effector cells of these tumors in vitro and in vivo in nude mice. The lines were established from explants using differential trypsinization and culture for 2 to 20 mo. The explants were derived from 11 different sites. Three pairs of lines were derived from both the primary tumor and metastatic lymph nodes in the same patients. All cultures grew as either compact or diffuse adherent monolayers, and they had a median doubling time of 86 h (range, 33 to 531 h). DNA fingerprinting confirmed that the HNSCC lines were individual isolates. Thirteen of 14 lines tested induced tumors in athymic mice. The histology of each line growing in nude mice was similar to that of the original tumor tissue. Immunocytochemistry showed keratin production in all lines tested. ...
Cell Lines and Reagents. UM-22A, UM-22B, and 1483 are human HNSCC cell lines (Lin et al., 2007a) and were grown in Dulbeccos modified Eagles medium (DMEM) supplemented with 10% heat-inactivated fetal bovine serum (FBS) and antibiotics. ABT-737 and A-793844 were provided by Abbott Laboratories (Abbott Park, IL), dissolved in DMSO, and stored at -80°C as 10 mM stocks. Cisplatin was obtained from the University of Pittsburgh Cancer Institute Pharmacy, and etoposide was from Sigma (St. Louis, MO). Lipofectamine 2000 reagent was obtained from Invitrogen (Carlsbad, CA), and Annexin V-fluorescein isothiocyanate apoptosis detection kits were from BD Biosciences (San Jose, CA). Anti-Bcl-2 antibody was from Dako (Glostrup, Denmark), and antibodies against Bcl-XL, Bax, Noxa, and Mcl-1 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA). Antibodies against PARP and Bak were obtained from Cell Signaling Technology (Danvers, MA), and anti-caspase-3 was from Assay Designs (Ann Arbor, MI). ...
Head and neck cancer accounts for approximately 6% of diagnosed malignancies in the United States, with an estimated 35,000 incidences and over 7,000 deaths every year. Head and neck squamous cell carcinoma (HNSCC) comprises the majority of head and neck cancers, with a worldwide incidence of more than 500,000 cases. Head and neck cancer patients often present in advanced stages of disease, and despite ongoing research, survival rates remain lower than other more common malignancies. Cytokines and pro-inflammatory factors have been shown to have a critical role in the various steps of malignant transformation, including tumor growth, survival, invasion, angiogenesis, and metastasis. Mitogen-activated protein kinases (MAPK), such as p38, JNK, and ERK, relay information from extracellular signals to the effectors that control these diverse cellular processes. Negative regulation of MAPK activity is provided by MAPK phosphatases that dephosphorylate MAPK proteins. The founding member of this class ...
Brachytherapy treatment solutions for head & neck cancers by Elekta. Wide array of applicators including the Rotterdam. Standalone or combination treatment.
The presence of metastatic disease in cervical lymph nodes of head and neck squamous cell carcinoma (HNSCC) patients is a very important determinant in therapy choice and prognosis, with great impact in overall survival. Frequently, routine lymph node staging cannot detect occult metastases and the post-surgical histologic evaluation of resected lymph nodes is not sensitive in detecting small metastatic deposits. Molecular markers based on tissue-specific microRNA expression are alternative accurate diagnostic markers. Herein, we evaluated the feasibility of using the expression of microRNAs to detect metastatic cells in formalin-fixed paraffin-embedded (FFPE) lymph nodes and in fine-needle aspiration (FNA) biopsies of HNSCC patients. An initial screening compared the expression of 667 microRNAs in a discovery set comprised by metastatic and non-metastatic lymph nodes from HNSCC patients. The most differentially expressed microRNAs were validated by qRT-PCR in two independent cohorts: i) 48 FFPE lymph
These data suggest that pembrolizumab plus cetuximab may have promising activity for platinum-refractory or -ineligible patients with recurrent or metastatic head and neck squamous cell carcinoma, said Assuntina G. Sacco, MD, Associate Professor of Medicine and Medical Director of Infusion Services at UC San Diego Moores Cancer Center, La Jolla, California. The safety profile was also acceptable, resulting in few treatment-related discontinuations. Ongoing and future studies of combined anti-PD-1 and EGFR inhibition are indicated.. As Dr. Sacco reported, it is well established that patients with recurrent or metastatic head and neck squamous cell carcinoma who are either platinum-refractory or -ineligible have poor survival outcomes. Although there are U.S. Food and Drug Administration-approved therapies in the second-line setting, including both checkpoint inhibitors (pembrolizumab and nivolumab) and an EGFR inhibitor (cetuximab), she added, these agents are approved only as ...
PRLR expression in SCCHN cell lines. (A) PRLR expression measured by flow cytometry in PCI-6A, PCI-6B and T47D cell lines. The PCI-6A cell line shows a signific
Head And Neck Cancer Squamous Cell Carcinoma - Pipeline Review, H2 2014SummaryGlobal Markets Directs, Head And Neck Cancer Squamous Cell Carcinoma - Pipeline Review, H2 2014, provides an overview of the Head And Neck Cancer Squamous Cell Carcinomas therapeutic pipeline.This report provides comprehensive information on the therapeutic development for Head And Neck Cancer Squamous Cell Carcinoma, co
Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease marked by frequent recurrence and metastasis and stagnant survival rates. To enhance molecular knowledge of HNSCC and define a non-coding RNA (ncRNA) landscape of the disease, researchers at UCSD profiled the transcriptome-wide dysregulation of long non-coding RNA (lncRNA), microRNA (miRNA), and PIWI-interacting RNA (piRNA) using RNA sequencing data from 422 HNSCC patients in The Cancer Genome Atlas (TCGA). 307non-coding transcripts differentially expressed in HNSCC were significantly correlated with patient survival, and associated with mutations in TP53, CDKN2A, CASP8, PRDM9,and FBXW7 and copy number variations in chromosomes 3, 5, 7, and 18. The researchers also observed widespread ncRNA correlation to concurrent TP53 and chromosome 3p loss, a compelling predictor of poor prognosis in HNSCCs. Three selected ncRNAs were additionally associated with tumor stage, HPV status, and other clinical characteristics, and modulation ...
In an Indian phase III trial reported in the Journal of Clinical Oncology, Vanita Noronha, MD, of Tata Memorial Hospital, Mumbai, and colleagues found that curative-intent adjuvant chemoradiation with cisplatin at 100 mg/m2 every 3 weeks produced better locoregional control vs cisplatin at 30 mg/m2 every week in patients with locally advanced head and neck squamous cell cancer.1 Severe adverse events were more common in the every-3-week group.. Study Details. In the noninferiority trial, 300 patients with locally advanced head and neck cancer at Tata Memorial Center in Mumbai were randomized between 2013 and 2017 to receive cisplatin at 30 mg/ m2 given once a week (n = 150) vs cisplatin at 100 mg/m2 given once every 3 weeks (n = 150), both administered concurrently with curative-intent radiotherapy. Disease had to be locally advanced with no distant metastases with planned curative chemoradiation, either as adjuvant treatment for ≥ 1 high-risk feature (eg, extracapsular extension, close [≤ 5 ...
Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer and frequently metastasizes to LNs. Identifying metastasis-promoting factors is of immense clinical interest, as the prognosis for patients with even a single unilateral LN metastasis is extremely poor. Here, we report that p90 ribosomal S6 kinase 2 (RSK2) promotes human HNSCC cell invasion and metastasis. We determined that RSK2 was overexpressed and activated in highly invasive HNSCC cell lines compared with poorly invasive cell lines. Expression of RSK2 also correlated with metastatic progression in patients with HNSCC. Ectopic expression of RSK2 substantially enhanced the invasive capacity of HNSCC cells, while inhibition of RSK2 activity led to marked attenuation of invasion in vitro. Additionally, shRNA knockdown of RSK2 substantially reduced the invasive and metastatic potential of HNSCC cells in vitro and in vivo in a xenograft mouse model, respectively. Mechanistically, we determined that ...
TY - JOUR. T1 - Treatment of advanced or recurrent squamous cell carcinoma of the uterine cervix with mitomycin-C, bleomycin, and cisplatin chemotherapy. AU - Smith, Harriet O.. AU - Stringer, C. Allen. AU - Kavanagh, John J.. AU - Gershenson, D. M.. AU - Edwards, C. L.. AU - Wharton, J. T.. PY - 1993/1. Y1 - 1993/1. N2 - Fifty-nine patients with recurrent/persistent, or advanced local/metastatic squamous cell cancer of the cervix were treated with combination chemotherapy consisting of mitomycin-C, bleomycin, and cisplatin. Response to therapy and survival analysis was determined for 44 of 49 patients who had previously been treated with radiation therapy and/or surgery and for 10 patients with advanced, previously untreated disease. Seven (16%) of the 44 previously treated patients experienced either complete response (CR) or partial response (PR). The median progression-free interval for responders (CR + PR) was 14.5 months, compared with 2.6 months for the nonresponders (significant, P , ...
Human Papilloma Virus Attributable Head and Neck Cancer in the Sudan Assessed by p16INK4A Immunostaining Head and neck cancer;human papillomavirus;$p16^{INK4A}$;Sudan; Background: The aim of this study was to screen for human papillomavirus (HPV) infections in head and neck squamous cell carcinomas (HNSCCs) using P16 immunostaining. Materials and Methods: A retrospective study was performed on 150 samples from patients diagnosed with HNSCCs. HPV status was determined using $p16^{INK4A}$. Results: 31 of the 150 (20.7%) HNSCCs were HPV positive. Conclusions: A large proportion of HNSCCs in Sudan are associated with HPV infection. The fact that the prevalence of HPV is high among Sudanese patients with head and neck cancers (HNC) has obvious implications for vaccine therapy.
This Melanoma and Head & Neck Cancer/Genitourinary & Gynecologic Tumors Online course is offered multiple times in a variety of locations and training topics.
Metformin is commonly used for treating type 2 diabetes, and may also reduce cancer risk. Previous studies have demonstrated the association between metformin use and a decreased risk of head and neck cancer. Therefore, the aim of the present systematic review was to summarize the available literature on the in vitro anti‑tumor effects of metformin on head and neck squamous cell carcinoma (HNSCC). Research studies were obtained from Cochrane Library, Embase, LILACS, MEDLINE and PubMed databases, without time or language restrictions. Only in vitro studies analyzing the effects of metformin on HNSCC cell lines were included. The authors methodically appraised all the selected studies according to the Grading of Recommendations Assessment, Development and Evaluation method to make a judgment of the evidence quality. Of the 388 identified reports, 11 studies met the inclusion criteria and were used for qualitative analysis. These studies demonstrated that metformin is important in inhibiting cell ...
Head and neck squamous cell carcinoma (HNSCC) represents a major health concern worldwide. We applied the matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) to analyze paired normal (N) and tumor (T) samples from head and neck squamous cell carcinoma as well as liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis in HNSCC cell lines to identify tumor-associated biomarkers. Our results showed a number of proteins found to be over-expressed in HNSCC. We identified thymosin beta-4 X-linked (TMSB4X) is one of the most significant candidate biomarkers. Higher TMSB4X expression in the tumor was found by N/T-paired HNSCC samples at both RNA and protein level. Overexpression of TMSB4X was found significantly associated with poor prognosis of overall survival (OS, P = 0.006) and recurrence-free survival (RFS, P = 0.013) in HNSCC patients. Silencing of TMSB4X expression in HNSCC cell line reduced the proliferation and invasion ability in vitro, as well ...
The role of c-erbB receptors and ligands in head and neck squamous cell carcinoma. c-erbB receptor signalling induces pleiotropic responses and influences several biological functions involved in the pathogenesis and progression of HNSCC. Aberrant expression of multiple c-erbB receptors and ligands is frequently observed in tumour cells. EGFR appears to be a dominant factor controlling the malignant phenotype in HNSCC at least in part via regulation of molecules involved in invasive and angio-/lymphangiogenic processes. Although c-erbB-2 is an orphan receptor, the formation of heterodimer complexes appears to be an important mechanism for inter-receptor activation and synergistic signal transduction. The roles of c-erbB-3 and c-erbB-4 in HNSCC progression are less clear. However, their ability to form heterodimers with other c-erbB family members enhances proliferation and invasion in HNSCC cells. At least two major downstream signalling pathways, MAPK and PI3K, are involved in the ...
Despite advances in diagnostic and treatment strategies, head and neck squamous cell cancer (HNSCC) constitutes one of the worst cancer types in terms of prognosis. PTEN is one of the tumour suppressors whose expression and/or activity have been found to be reduced in HNSCC, with rather low rates of mutations within the PTEN gene (6-8%). We reasoned that low expression levels of PTEN might be due to a transcriptional repression governed by an oncogene. Tbx2 and Tbx3, both of which are transcriptional repressors, have been found to be amplified or over-expressed in various cancer types. Thus, we hypothesize that Tbx3 may be over expressed in HNSCC and may repress PTEN, thus leading to cancer formation and/or progression. Using immunohistochemistry and quantitative PCR (qPCR), protein and mRNA levels of PTEN and Tbx3 were identified in samples excised from cancerous and adjacent normal tissues from 33 patients who were diagnosed with HNSCC. In addition, HeLa and HEK cell lines were transfected with a Tbx3
BACKGROUND: Salvage surgery after concomitant chemoradiation therapy (CCRT) for patients with head and neck squamous cell carcinomas (HNSCC) is challenging because of its associated morbidity/mortality and the poor prognoses of these patients. METHODS: The outcome analysis of prospectively collected data from 93 patients with HNSCC with local and/or regional shows treatment failures but without distant metastasis after CCRT. RESULTS: Thirty-eight patients underwent salvage surgery, whereas 55 underwent palliative treatment, with 2-year overall survival rates of 43.4% and 0%, respectively. Initial stage IV tumors (p = .017) and concurrent local and regional failures (p = .003) were independent predictors for decreased survival after salvage surgery. Two-year overall survival rates for patients with 2, 1, or none of these predictive factors were 0%, 49%, and 83%, respectively (p = .0005). CONCLUSION: Salvage surgery after CCRT has acceptable outcomes. Initial stage IV tumors and concurre
Rittà, M., De Andrea, M., Mondini, M., Mazibrada, J., Giordano, C., Pecorari, G., Garzaro, M., Landolfo, V., Schena, M., Chiusa, L. and Landolfo, S. (2009), Cell cycle and viral and immunologic profiles of head and neck squamous cell carcinoma as predictable variables of tumor progression. Head Neck, 31: 318-327. doi: 10.1002/hed.20977 ...
Cisplatin, 5-fluorouracil, and cetuximab (PFE) with or without cilengitide in recurrent/metastatic squamous cell carcinoma of the head and neck : results of the randomized phase I/II ADVANTAGE trial (phase II part) ...
The radical neck dissection specimens of 384 ethnically Chinese patients with different primary squamous carcinomas in the head and neck region were studied. Over 50 per cent of the specimens showed metastatic disease at one level in the neck. For oral cavity carcinoma, the levels of metastasis frequently involved were I, II and III while for carcinoma of the oropharynx, hypopharynx and larynx, the levels were II, III and IV. Extracapsular spread was present in 112/384 of patients (29 per cent) and this increased with advancing N-stages. Based on these findings, different selective neck dissections could be used for patients harbouring different primary head and neck carcinomas with limited neck disease ...
Head and neck squamous cell carcinoma (HNSCC) is comprised of metabolically linked distinct compartments. Cancer-associated fibroblasts (CAF) and nonproliferative carcinoma cells display a glycolytic metabolism, while proliferative carcinoma cells rely on mitochondrial oxidative metabolism fueled by the catabolites provided by the adjacent CAFs. Metabolic coupling between these reprogrammed compartments contributes to HNSCC aggressiveness. In this study, we examined the effects of cigarette smoke-exposed CAFs on metabolic coupling and tumor aggressiveness of HNSCC. Cigarette smoke (CS) extract was generated by dissolving cigarette smoke in growth media. Fibroblasts were cultured in CS or control media. HNSCC cells were cocultured in vitro and coinjected in vivo with CS or control fibroblasts. We found that CS induced oxidative stress, glycolytic flux and MCT4 expression, and senescence in fibroblasts. MCT4 upregulation was critical for fibroblast viability under CS conditions. The effects of CS ...
... is performed mostly by head and neck surgeons. There are two parotid glands in the human body. Each parotid gland ... Typically performed if neoplasm is affecting deep part of parotid gland. Surgeon tries to remove the gland apart from the ... of all head and neck cancers. The root of the word parotidectomy, parotid, refers to the parotid gland meaning "situated near ... Benign parotid gland neoplasms typically present after the age of 40 and have an equal presentation in both genders. Malignant ...
Mills SE (March 2002). "Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas". Modern ... Melanoma is a type of neuroectodermal neoplasm. There are four main types of melanoma: Other histopathologic types are: Mucosal ... denoting a tissue mass and especially a neoplasm), in turn from Greek μέλας melas, "dark", and -ωμα oma, "process". The word ...
Stafne defect Barnes L (2008). Surgical pathology of the head and neck (3rd ed.). New York: Informa Healthcare. pp. 477-478. ... Salivary gland neoplasm occurrence within heterotopic salivary gland tissue is rare. ...
Keat Jin Lee (2003). Essential otolaryngology: head & neck surgery. McGraw-Hill Professional. p. 1052. ISBN 978-0-07-137322-7. ... Matutes E (May 2018). "The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms". International Journal of ... Otolaryngology-Head and Neck Surgery. 114 (4): 653-6. doi:10.1016/s0194-5998(96)70264-4. PMID 8643282. ...
Affected regions include the head and neck region and the upper part of the trunk. It may coexist with certain neoplasms or ...
Some head and neck tumours invade or compress the facial nerve leading to facial paresis or paralysis. Examples of such tumours ... are facial neuromas, cholesteatomas, hemangiomas, acoustic neuromas, parotid gland neoplasms or metastases. Sometimes, the ... Tate JR, Tollefson TT (August 2006). "Advances in facial reanimation". Curr Opin Otolaryngol Head Neck Surg. 14 (4): 242-8. doi ... Otolaryngol Head Neck Surg. 141 (1): 139-41. doi:10.1016/j.otohns.2009.03.005. PMID 19559974. Faria JC, Scopel GP, Ferreira MC ...
Mino M, Pilch BZ, Faquin WC (December 2003). "Expression of KIT (CD117) in neoplasms of the head and neck: an ancillary marker ... "Treatment of salivary gland neoplasms with fast neutron radiotherapy". Arch. Otolaryngol. Head Neck Surg. 129 (9): 944-8. doi: ... The head, neck, mouth, and throat will be checked for signs of disease, such as lumps or anything else that seems unusual. A ... Head and neck cancer Salivary gland pathology Zaleski, Michael P.; Kalhor, Neda; Moran, Cesar A. (November 2020). "Mucous Gland ...
"Expanding fields of genetically altered cells in head and neck squamous carcinogenesis". Semin. Cancer Biol. 15 (2): 113-20. ... which may be benign neoplasms) or else a malignant neoplasm (cancer). These neoplasms are also indicated, in the diagram below ... to field defects include head and neck squamous cell carcinoma (HNSCC), oropharyngeal/laryngeal cancer, esophageal ... The Hallmarks of Cancer as evolutionary adaptations in a neoplasm[edit]. In their landmark paper, The Hallmarks of Cancer,[3] ...
2005), World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours (PDF), World Health ... The WHO/IARC classification no longer considers it a neoplasm, because the evidence supporting that hypothesis (for example, ... 2017), WHO Classification of Head and Neck Tumours, WHO/IARC Classification of Tumours, 9 (4th ed.), Lyon, France: IARC Press, ... In the WHO/IARC classification of head and neck pathology, this clinical entity had been known for years as the odontogenic ...
a b Illustrated Anatomy of the Head and Neck, Fehrenbach and Herring, Elsevier, 2012, p. 97 ... and maxillofacial neoplasms. However, no other signs are present except those involved in changes in occlusion intraorally such ... The fibers of the two heads are continuous at their insertion. Superficial head[edit]. The superficial head, the larger, arises ... Deep head[edit]. The deep head is much smaller, and more muscular in texture. It arises from the posterior third of the lower ...
Kum YS, Kim JK, Cho CH, Kim HK (2009). "Intraneural reticular perineurioma of the hypoglossal nerve". Head Neck. 31 (6): 833-7 ... A clonal neoplasm associated with abnormalities of chromosome 22". Am J Clin Pathol. 103 (6): 696-704. doi:10.1093/ajcp/103.6. ... a distinctive and underrecognized peripheral nerve sheath neoplasm". Archives of Pathology & Laboratory Medicine. 131 (4): 625- ...
A paraganglioma is a rare neuroendocrine neoplasm that may develop at various body sites (including the head, neck, thorax and ... Head and neck paraganglioma (HNPGL): There are various types of head and neck paraganglioma; they may have specialized names ... Vagal paraganglioma: These are the least common of the head and neck paragangliomas. They usually present as a painless neck ... Is the most common of the head and neck paragangliomas. It usually presents as a painless neck mass, but larger tumors may ...
... or with radiation therapy to certain nausea-producing structures in the head during treatment of certain head and neck tumors, ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... If the head and neck area is treated, temporary soreness and ulceration commonly occur in the mouth and throat.[12] If severe, ... For example: non-melanoma skin cancer, head and neck cancer, breast cancer, non-small cell lung cancer, cervical cancer, anal ...
... s are 2 to 4 mm in diameter, dome-shaped, yellowish or skin-colored papules usually located on the head, neck, ... List of cutaneous conditions List of cutaneous neoplasms associated with systemic syndromes Trichodiscoma Freedberg, et al. ( ...
... head and neck, leukemia, lymphoma, lung, osteosarcoma, bladder, and trophoblastic neoplasms. It is used as a disease-modifying ... a study of 93 patients with incurable neoplasms". Journal of the National Medical Association. 43 (4): 211-40. PMC 2616951. ...
Though MRI is less accurate for identifying infiltration to head and neck tumors. Due to the rarity, initial presentation of ... As with many other stromal neoplasms, DFSPs appear to express low levels of hormone receptors, which may be one factor that ... Trunk / Torso - 42% Lower extremity - 21% Upper extremity - 21% Head and neck - 13% Genitals - 1% Bednar, or pigmented DFSP, is ... The dissonance between the name of the neoplasm and its clinical presentations may cause a majority of patients to experience a ...
Muscles of the head and neck. Dissection, showing salivary glands of right side (Masseter visible at center) Left temporal bone ... and maxillofacial neoplasms. However, no other signs are present except those involved in changes in occlusion intraorally such ... Veins of the head and neck. Mandibular division of the trifacial nerve. Masseter muscle. Deep dissection. Mummification process ... ISBN 0-03-910284-X. Illustrated Anatomy of the Head and Neck, Fehrenbach and Herring, Elsevier, 2012, p. 97. ...
Treatment of Salivary Gland Neoplasms with fast neutron Radiotherapy. Arch Otolaryngol Head Neck Surg Vol 129 944-948 Sep 2003 ... Various other head and neck tumors have been examined. No cancer therapy is without the risk of side effects. Neutron therapy ... For instance, some of the most remarkable cures it has been able to achieve are with cancers of the head and neck. Many of ... The treatment of recurrence following fast neutron therapy for head and neck malignancy. Clin Otolaryngol Allied Sci. 1996 Jun; ...
The three-story facility houses outpatient space for evaluation and treatment of solid tumor neoplasms including: lung, head ... and Head, Neck and Respiratory disease. A linear accelerator and brachytherapy unit are located in the basement of the Ben F. ... and neck, sarcoma, GI, and urologic cancers (1st floor); breast cancer (2nd floor); and gynecologic cancers (3rd floor). Markey ...
IH most commonly presents in the head and neck region (60%), but also involves the trunk and extremities. One third of these ... Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm that is locally aggressive but without metastatic potential. ... It mainly affects the limbs (52%), but also the head and neck region (42%) and the trunk (6%). The non-involuting congenital ... It commonly presents in the head and neck and in the lower extremities. Congenital hemangioma are divided into 2 subgroups: the ...
... head and neck, leukemia, lymphoma, lung, osteosarcoma, bladder, and trophoblastic neoplasms.[1] ... A study of 93 patients with incurable neoplasms". J Natl Med Assoc. 43 (4): 211-240. PMC 2616951. PMID 14850976.. ...
These epigenetic defects occurred in various cancers (e.g. breast, ovarian, colorectal and head and neck). Two or three ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... Tawfik HM, El-Maqsoud NM, Hak BH, El-Sherbiny YM (2011). "Head and neck squamous cell carcinoma: mismatch repair ... The term 'neoplasm' is a synonym of "tumor". 'Neoplasia' denotes the process of the formation of neoplasms/tumors, the process ...
Usually limited to the head, neck, scalp or face and vulva. Lesions are generally solitary and sporadic and may be associated ... analysis of clinicopathologic features of a distinctive follicular adnexal neoplasm". J. Am. Acad. Dermatol. 47 (3): 423-8. doi ... single keratotic nodule mainly confined to the head and neck as mentioned earlier. Warty dyskeratoma must be differentiated ... by HPV and the majority of these lesions display overall histopathologic features consistent with a follicular adnexal neoplasm ...
... head and neck carcinomas, endometrial cancer, breast cancer, acute T cell leukemia/lymphoma, Wilms' tumor, testicular germ cell ... In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... "Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinoma". Oncogene. 18 (50): 7063-7069. doi: ... adrenocortical neoplasms, choriocarcinomas, hepatocellular carcinomas, bladder cancers, ovarian serous epithelial cancers, ...
... carcinoma of the head or neck, and other neoplasms (e.g., lung cancer, lymphoma, and leukemia). Diet may also modulate risk. ...
The lesion usually presents as a slow-growing tumor of the skin and subcutaneous tissues of the head, neck, or extremity, of ... Hemangioendotheliomas are a family of vascular neoplasms of intermediate malignancy. They have been described as masses that ... including the head and neck, intestines, lymph nodes, pleura, retroperitoneum, heel, stomach.[citation needed] Possibly ...
... ulcerated papule on the head or neck and may mimic nonmelanoma skin cancers, molluscum contagiosum, adnexal neoplasms, or ... It is predominantly seen in the head and neck region given the high density of sebaceous glands in this region. The periocular ... Other SGc including those occurring outside of the head and neck region and the presentation of multiple at a time are believed ... Ouyang, Yun-Hsuan (May 2010). "Skin Cancer of the Head and Neck". Seminars in Plastic Surgery. 24 (2): 117-126. doi:10.1055/s- ...
Head and Neck Cancer Chapter 74: Neoplasms of the Lung Chapter 75: Breast Cancer Chapter 76: Upper Gastrointestinal Tract ... Back and Neck Pain Section 2: Alterations in Body Temperature Chapter 15: Fever Chapter 16: Fever and Rash Chapter 17: Fever of ... Polycythemia Vera and Other Myeloproliferative Neoplasms Chapter 100: Acute Myeloid Leukemia Chapter 101: Chronic Myeloid ...
... of the head and neck. Carcinoma is a term for malignant neoplasms derived from cells of epithelial lineage, and/or that exhibit ...
Eye neoplasm. G. *Gallbladder cancer. *Gastrointestinal cancer. H. *Head and neck cancer ...
... head & neck surgeon/ENT surgeon, pediatrician/internal medicine/hospitalist and a multidisciplinary team of support staff and ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Eye_neoplasm&oldid=895356793" ...
The image of the thyroid in the neck is due to unwanted uptake of radioiodine (as iodide) by the thyroid, after breakdown of ... Accumulation at the sides of the head is from salivary gland due to uptake of I-131 mIBG by the sympathetic neuronal elements ... "Malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism: a report of the cooperative ...
"CNS and Miscellaneous Intracranial and Instraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp ... Head/Neck (Oral, Nasopharyngeal). *Digestive system. *Respiratory system. *Bone. *Skin. *Blood. *Urogenital ...
Colon and head and neck cancer. 9. $1.73 billion. Leuprorelin. Lupron, Eligard. AbbVie and Takeda; Sanofi and Astellas Pharma. ... Secondary neoplasm[edit]. Development of secondary neoplasia after successful chemotherapy or radiotherapy treatment can occur ... The girl at left has a central venous catheter inserted in her neck. The girl at right has a peripheral venous catheter. The ... The most common secondary neoplasm is secondary acute myeloid leukemia, which develops primarily after treatment with ...
Promoter hypermethylation of NEIL1 occurs in 62% of head and neck cancers and in 42% of non-small-cell lung cancers. Promoter ... see malignant neoplasms). Thus, CpG island hyper/hypo-methylation in the promoters of DNA repair genes are likely central to ... In head and neck squamous cell carcinomas at least 15 DNA repair genes have frequently hypermethylated promoters; these genes ... Promoter hypermethylation of FANCB occurs in 46% of head and neck cancers. ...
Neoplasms and cancer. *Other *paralytic syndromes. *ALS. *Symptoms and signs *head and neck ... "Neoplasms and cancer" has been chosen to reflect the fact that not all tumours are benign. The word "cancer" has been included ...
Barnes L (editor) (2009). Surgical pathology of the head and neck (3rd ed.). New York: Informa healthcare. ISBN 9781420091632. ... Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ... Extremities (face, dorsal hands, arms, and nape of neck).[a] This is more common in Middle Eastern countries in spring and ...
CS1 maint: Uses authors parameter (link) Thompson, Lester D.R. (2016), Diagnostic Pathology: Head and Neck, 2e, Elsevier, ISBN ... Definition of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A noninvasive neoplasm that ... Follicular Neoplasm or Suspicious for a Follicular Neoplasm (Bethesda Category IV); Suspicious for Malignancy (Bethesda ... Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was ...
For certain types of cancer, such as early head and neck cancer, it may be used alone.[155] For painful bone metastasis, it has ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Tobacco smoke, for example, causes 90% of lung cancer.[34] It also causes cancer in the larynx, head, neck, stomach, bladder, ... Engraving with two views of a Dutch woman who had a tumor removed from her neck in 1689 ...
January 1, 2011). Differential diagnosis in otolaryngology - head and neck surgery. New York: Thieme. ISBN 978-1-60406-279-3. . ... Salivary gland neoplasms *Benign: Basal cell adenoma. *Canalicular adenoma. *Ductal papilloma. *Monomorphic adenoma ... inflammation of the lymph nodes in the neck). The fevers occur periodically about every 3-5 weeks. The condition appears to ...
To examine the brain, an incision is made from behind one ear, over the crown of the head, to a point behind the other ear. ... a single vertical incision is made from the sternal notch at the base of the neck. ... "Treatable abdominal pathologic conditions and unsuspected malignant neoplasms at autopsy in veterans who received mechanical ... When the autopsy is completed, the incision can be neatly sewn up and is not noticed when the head is resting on a pillow in an ...
"Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC)". Journal of Experimental & ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ...
... bit a 22-month-old girl after the snake had been placed around her neck (Washington County). The child died in approximately 5 ... or have a dark or black head. ... Neoplasms and cancer *nevi and melanomas. *epidermis. *dermis. ... Great Neck, NY: Scholium International. p. 163. ISBN 0-87936-015-1.. ...
head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection. *Vertebral artery dissection ... Myeloproliferative neoplasms including essential thrombocytosis and polycythemia vera[8]. *Chemotherapy[7][19] ... they can be responsible for a lung embolism mainly if the head of the clot is poorly attached to the vein wall and is situated ... thrombosis of the veins of the brain and head ...
head and neck. *cranial. *arms. *torso and pelvis. *legs. *bursae and sheathes ...
The body of the pancreas travels from the head, separated by a short neck. The neck is about 2 cm (0.79 in) wide, and sits in ... "Solid pseudopapillary neoplasm of the pancreas: a single institution experience of 14 cases". HPB. 8 (2): 148-50. doi:10.1080/ ... The body and neck of the pancreas drain into the splenic vein, which sits behind the pancreas. The head drains into, and wraps ... Anatomically, the pancreas is divided into a head, neck, body, and tail. The pancreas stretches from the inner curvature of the ...
The blisters often erupt in waves, usually affecting the upper trunk, head, neck, and proximal extremities. Pemphigoid-like ... in association with an underlying neoplasm". A study concluded in 2009, summarized in 2010, surrounded the surgical removal of ... ranging from small red scaly papules to extensive violet to brown papules extending to the face and neck. Within the spectrum ...
Basal-cell skin cancer (BCC) usually presents as a raised, smooth, pearly bump on the sun-exposed skin of the head, neck, torso ... Tumors: Skin neoplasm, skin appendages / Adnexal and skin appendage (C44.L40-L68/D23.L15-49, 173/216) ... Tumors: Skin neoplasm, nevi and melanomas (C43/D22, 172/216, ICD-O 8720-8799) ...
head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection. *Vertebral artery dissection ... Head. sinuses. Sinusitis. nose. Rhinitis Vasomotor rhinitis. Atrophic rhinitis. Hay fever. Nasal polyp. Rhinorrhea. nasal ... Neck. pharynx. Pharyngitis Strep throat. Laryngopharyngeal reflux (LPR). Retropharyngeal abscess. larynx. Croup. Laryngitis. ...
Neoplasms and cancer. *Other *paralytic syndromes. *ALS. *Symptoms and signs *head and neck ...
Head and neck[edit]. *Esophageal cancer. *Head and neck cancer. *Nasopharyngeal carcinoma ... Multiple myeloma/plasma cell neoplasm. *Myelodysplastic syndromes. *Mucosa-associated lymphoid tissue lymphoma ...
"Head and Neck Pathology. 3 (1): 1-17. doi:10.1007/s12105-008-0095-9. PMC 2807538. PMID 20596983.. ... This is a very rare neoplasm accounting for approximately 0.0003% of all tumors and about 2.5% of all external ear neoplasms. ... Lester D. R. Thompson; Bruce M. Wenig (2011). Diagnostic Pathology: Head and Neck: Published by Amirsys. Hagerstown, MD: ... Ceruminous adenocarcinoma is a malignant neoplasm derived from ceruminous glands of the external auditory canal. This tumor is ...
head / neck *Intracranial aneurysm. *Intracranial berry aneurysm. *Carotid artery dissection. *Vertebral artery dissection ... Neoplasms III D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ...
Of all pyogenic granulomas, 62% is distributed on the head or neck, occurring mainly on the cheek and in the oral cavity. ... Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm that is locally aggressive but without metastatic potential. ... Venous malformations usually occur in the head and neck.[12] Venous malformations are the most common vascular anomaly, making ... It commonly presents in the head and neck and in the lower extremities. Congenital hemangioma are divided into 2 subgroups: the ...
Bailey BJ, Johnson JT, Newlands SD (2006). Head and Neck Surgery: Otolaryngology. Lippincott Williams & Wilkins. p. 2,490.. ... Neoplasms - malignant and benign tumors. *Septal hematoma - a mass of (usually) clotted blood in the septum ... Anderson JR, Johnson CM, Adamson P (1982). "Open Rhinoplasty: An Assessment". Otolaryngology-Head and Neck Surgery. 90 (2): 272 ... Archives of Otolaryngology-Head & Neck Surgery. 132 (11): 1183-8. doi:10.1001/archotol.132.11.1183. PMID 17116812.. ...
... into the thick head, the neck, and the tapering body, ending in the tail. ... "Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas". The Sol Goldman Pancreas Cancer Research Center. ... A head-to-head trial between the two new options is awaited, and trials investigating other variations continue. However, the ... The head, body and tail of the pancreas. The stomach is faded out in this image to show the entire pancreas, of which the body ...
Some polyps are tumors (neoplasms) and others are nonneoplastic (for example, hyperplastic or dysplastic). The neoplastic ones ... neck pain, decreased pitch range in the voice, and vocal and bodily fatigue. ...
"Head and Neck Tumors" in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (eds.) Cancer Management: A Multidisciplinary Approach ... in-situ neoplasm. ...
Neoplasms. Head and Neck Neoplasms. Thoracic Neoplasms. Tobacco Use Disorder. Substance-Related Disorders. Chemically-Induced ... Tobacco Use Disorder Head and Neck Neoplasms Thoracic Neoplasms Radiation Other: Comprehensive smoking cessation intervention ... New diagnosis of head and neck or thoracic (including lung) cancer. *Undergoing radiation at Johns Hopkins Radiation Oncology ... Smoking is the greatest risk factor for upper aerodigestive cancers (thoracic or head and neck) and negatively impacts survival ...
They are partially responsible for the limited improvement in survival of head and neck cancer during the past 20 years. Only a ... Multiple primary tumors are a known phenomenon in head and neck cancer. ... Neoplasms, Multiple Primary / epidemiology* * Neoplasms, Second Primary / diagnosis * Neoplasms, Second Primary / epidemiology ... They are partially responsible for the limited improvement in survival of head and neck cancer during the past 20 years. Only a ...
Urinary System Neoplasms (13) * Head & Neck Neoplasms (8) * Skeletal System Neoplasms (7) ...
Head and Neck Neoplasms 18% * Squamous Cell Carcinoma 15% * Melanoma 15% * Observation 12% ... Lymphoscintigraphy and sentinel node biopsy: A potential new approach in the management of the N0 neck. ... A potential new approach in the management of the N0 neck. Together they form a unique fingerprint. ...
Dive into the research topics of Surgeons and nurses use of E-mail communication with head and neck cancer patients. ... Surgeons and nurses use of E-mail communication with head and neck cancer patients. ...
Head and Neck Neoplasms Medicine & Life Sciences 87% * Squamous Cell Carcinoma of Head and Neck Medicine & Life Sciences 58% ... Kim, M. M., & Califano, J. A. (2004). Molecular pathology of head-and-neck cancer. International Journal of Cancer, 112(4), 545 ... Kim, MM & Califano, JA 2004, Molecular pathology of head-and-neck cancer, International Journal of Cancer, vol. 112, no. 4, ... Kim, Michael M. ; Califano, Joseph A. / Molecular pathology of head-and-neck cancer. In: International Journal of Cancer. 2004 ...
Felton, S., Stan Taylor, R., & Srivastava, D. (2016). Excision margins for melanoma in situ on the head and neck. Dermatologic ... Felton, S, Stan Taylor, R & Srivastava, D 2016, Excision margins for melanoma in situ on the head and neck, Dermatologic ... Excision margins for melanoma in situ on the head and neck. In: Dermatologic Surgery. 2016 ; Vol. 42, No. 3. pp. 327-334. ... Excision margins for melanoma in situ on the head and neck. / Felton, Sarah; Stan Taylor, R.; Srivastava, Divya. ...
Head and Neck Neoplasms Medicine & Life Sciences 100% * Deglutition Medicine & Life Sciences 84% ... Radford K, Woods H, Lowe D, Rogers S. A UK multi-centre pilot study of speech and swallowing outcomes following head and neck ... A UK multi-centre pilot study of speech and swallowing outcomes following head and neck cancer. / Radford, K.; Woods, H.; Lowe ... Dive into the research topics of A UK multi-centre pilot study of speech and swallowing outcomes following head and neck ...
Head and Neck Neoplasms and RAD51C[original query] Rad51C: a novel suppressor gene modulates the risk of head and neck cancer. ... RAD51C--a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC). Oral oncology ...
Head and Neck Neoplasms Medicine & Life Sciences 12% * Progression-Free Survival Medicine & Life Sciences 10% ... Neck dissection after chemoradiotherapy: Timing and complications. Archives of Otolaryngology - Head and Neck Surgery. 2010 Nov ... In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 136, No. 11, 11.2010, p. 1071-1077.. Research output: Contribution ... Patients: One hundred five patients with head and neck cancer undergoing ND after CRT. Main Outcome Measures: Complications and ...
Head and Neck Neoplasms - radiotherapy - popular works - pamphlets. Language. English. Material Type. Pamphlet. Audience. ... Dont sit in the shade forever : the tale of Ann : a few tips and tidbits for head and neck cancer patients undergoing ... Neoplasms - complications. Infertility. Notes. Apr 30 2018: Removed for Library Search file cleanup project 2018. AR. Language ...
Head & Neck Cancer. * Hodgkin Lymphoma. * Living Well. * Lung Cancer. * Mantle Cell Lymphoma. ... Myeloproliferative Neoplasms. * Navigating Cancer. * Non-Hodgkin Lymphoma. * Pancreatic Cancer. * Prostate Cancer. * ...
Head & Neck Cancer. * Hodgkin Lymphoma. * Living Well. * Lung Cancer. * Mantle Cell Lymphoma. ... Myeloproliferative Neoplasms. * Navigating Cancer. * Non-Hodgkin Lymphoma. * Pancreatic Cancer. * Prostate Cancer. * ...
Head & Neck Cancer. * Hodgkin Lymphoma. * Living Well. * Lung Cancer. * Mantle Cell Lymphoma. ... Myeloproliferative Neoplasms. * Navigating Cancer. * Non-Hodgkin Lymphoma. * Pancreatic Cancer. * Prostate Cancer. * ...
Can they stretch their shoulder or the chest, even through the head and neck, things that make them feel like their body can ... Myeloproliferative Neoplasms. * Navigating Cancer. * Non-Hodgkin Lymphoma. * Pancreatic Cancer. * Prostate Cancer. * ... looking at strength training for women with breast cancer and lymphedema that really turned the medical community on their head ...
Head Neck Pathol 2014;8:339-48.. 8. Sreeram S, Lobo FD, Naik R, Khadilkar UN, Kini H, Kini UA. Morphological spectrum of basal ... Woods TR, Cohen DM, Islam MN, Kratochvil FJ, Stewart JC, Reeder SL, et al. Intraoral basal cell carcinoma, a rare neoplasm: ... Indian J Otolaryngol Head Neck Surg 2013;65:160-2.. 14. Tengli MB, Roohi S, Yelawanti GK, Chimkod R, Pattankar VL. Giant ... In a study conducted by the otorhinolaryngologists, among the Sikkimese population with NMSC (n = 37) in the head-and-neck ...
The head CT demonstrates multiple, bilateral, patchy foci of hypo attenuation within the subcortical white matter with some ... Head - Neck (113) * Infectious (50) * Inflammatory (54) * Inflammatory-Demyelinating (7) * Malformations (100) ...
They are usually located on the back of the head and neck, do not need treatment and pass on their own during the first year of ... This neoplasm is divided into and two types are divided: ordinary and vascular nevi.. Normal nevi are brown formations (from ... head, neck and other parts of the body... Today, the dream of many people who have to live with such cosmetic defects can ... They cannot develop into melanoma, just as ordinary brown neoplasms do not require treatment. However, they are trying to ...
Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic ... CONCLUSION: Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first ... Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic ... Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic ...
Head and Neck Neoplasms Medicine & Life Sciences 8% * Intravenous Administration Medicine & Life Sciences 8% ... In: Head and Neck, Vol. 36, No. 11, 01.11.2014, p. 1619-1627.. Research output: Contribution to journal › Article › peer-review ... In preparation for clinical testing in human squamous cell carcinoma (SCC) of the head and neck, we conducted preclinical ... In preparation for clinical testing in human squamous cell carcinoma (SCC) of the head and neck, we conducted preclinical ...
T cell lymphoma, lymph nodes of head, face, and neck * BILLABLE 202.72 Peripheral T cell lymphoma, intrathoracic lymph nodes ... Parent Code: 202 - Other malignant neoplasms of lymphoid and histiocytic tissue * 202.7 Peripheral t-cell lymphoma NON-BILLABLE ...
Head and Neck Neoplasms. *Phospholipases A. *Uric Acid. *Hepacivirus. *Hepatitis C, Chronic ...
1 Department of Otolaryngology and Head and Neck Surgery, Cattinara Hospital, University of Trieste, Trieste, Italy. ... 4 Department of Otolaryngology and Head and Neck Surgery, Cattinara Hospital, University of Trieste, Trieste, Italy. ...
Salivary glands located in the head and neck area are known to have different lesions with prominent oncocytic features. Fine ... keywords = "cytopathology, FNA, oncocytic lesions, oncocytic neoplasms, salivary glands",. author = "{El Hussein}, Siba and ... N2 - Salivary glands located in the head and neck area are known to have different lesions with prominent oncocytic features. ... AB - Salivary glands located in the head and neck area are known to have different lesions with prominent oncocytic features. ...
Population served: People with blood cancer (and lung or head & neck cancer), caregivers, health professionals. Mission: To ... physicians and caregivers of myeloproliferative neoplasms. ...
Functional and selective neck dissection. [Javier Gavilán; Alejandro Castro, (Chief of Head and Neck Surgery Division); Laura ... Head and Neck Neoplasms -- surgery. * Otorhinolaryngologic Surgical Procedures -- methods. User lists with this item (1) *Most ... Functional and selective neck dissection. Author:. Javier Gavilán; Alejandro Castro, (Chief of Head and Neck Surgery Division) ... Javier Gavilán; Alejandro Castro, (Chief of Head and Neck Surgery Division); Laura Rodrigáñez; Jesús Herranz. Find more ...
Head and Neck Neoplasms - radiotherapy - popular works - pamphlets 1 * Neoplasms - rehabilitation * Pain, Intractable - therapy ... Neoplasms - rehabilitation. Palliative Care - methods. Pain, Intractable - therapy. ISBN. 9782287728266. 2287728260. ISSN. 1768 ...
... cancer of the head and neck, or other reasons. After the primary treatment for the cause behind the physical deformities, ... cutaneous neoplasm, congenital anomaly, accident, or injury. ... or head and neck reconstruction surgery. A cosmetic surgery or ... he led a team of surgeons at Methodist Hospital to re-build Carolyn Thomass face after she was shot in the head. Dr. Gene and ...
Prevalence and characteristics of risk for malnutrition in patients with newly diagnosed head and neck cancer. ter Beek, L., ... energy expenditure estimates from bio-impedance equipment replace estimates by harris-benedict in patients with head and neck ...
  • They cannot develop into melanoma, just as ordinary brown neoplasms do not require treatment. (beautysummary.com)
  • Salivary glands located in the head and neck area are known to have different lesions with prominent oncocytic features. (elsevier.com)
  • Unlike more conventional radiation therapy, PBRT utilizes controlled proton beams to deliver high doses of radiation while minimizing lifelong side effects including permanent neck stiffness, loss of salivary glands and the formation of secondary cancers. (theaggie.org)
  • DHM1 will be responsible for products for acute leukemia and myelodysplasia (includes myelodysplastic-myeloproliferative overlap syndromes), chronic myeloid leukemia and other myeloproliferative neoplasms with the term "leukemia," blastic plasmacytoid dendritic cell neoplasm (BPDCN), conditioning regimens for DHM1 indications, graft versus host disease, tumor lysis syndrome, cytokine release syndrome, and CAR-T neurotoxicity. (cancerhealth.com)
  • We headed to Clayton, Missouri for a State of the Science Summit on Hematologic Malignancies, which focused on novel agents in chronic lymphocytic leukemia, advances in acute myeloid leukemia, progress in myeloproliferative neoplasms, and more. (onclive.com)
  • The meeting covered novel agents and combinations in chronic lymphocytic leukemia, advances in acute myeloid leukemia, management of newly diagnosed and relapsed/refractory multiple myeloma, progress in myeloproliferative neoplasms, patient selection for Hodgkin lymphoma therapy, and more. (onclive.com)
  • Multiple primary tumors are a known phenomenon in head and neck cancer. (nih.gov)
  • DO2 will review products for thoracic and head and neck cancers, central nervous system cancers, pediatric solid tumors, and rare cancers. (cancerhealth.com)
  • Granular cell tumors (GCT) are benign neoplasms that can occur in virtually every tissue and organ. (surgpath4u.com)
  • Carbon ion radiation is used in the treatment of various malignancies such as tumors of head and neck, skull base, lung cancer, liver, prostate, etc. (ac.rs)
  • The bulk of her tumor was surgically removed last March at MD Anderson, but the fragments left in her neck are considered malignant. (theaggie.org)
  • The authors prospectively studied 127 patients with squamous cell carcinoma of the head and neck. (nih.gov)
  • Each year approximately 40,000 people in the United States and 500,000 people worldwide are diagnosed with head-and-neck squamous cell carcinoma (HNSC). (elsevier.com)
  • RAD51C--a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC). (cdc.gov)
  • In preparation for clinical testing in human squamous cell carcinoma (SCC) of the head and neck, we conducted preclinical studies of VSV-IFN-β in syngeneic SCC models. (elsevier.com)
  • Virusul Papiloma - potenţială etiologi human papillomavirus în cazul neoplasmelor orofaringian și laringian Etiologi human papillomavirus, HPV genotipare în salivă Synevo HPV genotipare în salivă Lei Informaţii generale şi recomandări Cancerele capului şi gâtului - în majoritatea cazurilor etiologi human papillomavirus cu celule scuamoase HNSCC - Head and Neck Squamous Cell Carcinoma, în literatura engleză includ neoplazii ale cavităţii orale, orofaringelui, hipofaringelui, laringelui, tractului sinonazal şi nazofaringelui. (sarahcolors.ro)
  • Califano, Joseph A. / Molecular pathology of head-and-neck cancer . (elsevier.com)
  • METHODS: Paraffin-embedded tissue blocks of patients microscopically diagnosed with plasma cell neoplasms in the jaws were retrieved from five pathology files. (uandes.cl)
  • Benign fibrous histiocytoma of distal radius with congenital dislocation of radial head - a case report. (trustwellhospitals.com)
  • Ameloblastomas are benign, locally invasive, polymorphic neoplasms that consist of proliferating odontogenic epithelium (usually of a follicular or plexiform pattern) lying in a fibrous stroma [1]. (clinmedjournals.org)
  • PDGFRB-rearranged T-lymphoblastic leukemia/lymphoma occurring with myeloid neoplasms: the missing link supporting a stem cell origin. (vanderbilt.edu)
  • CONCLUSION: Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first complaint of the patient. (uandes.cl)
  • MATERIALS AND METHODS Three hundred forty-Three primary MIS cases on the head and neck treated in the authors' department by Mohs micrographic surgery (MMS) over a 65-month period were retrospectively analyzed. (elsevier.com)
  • Performance of Apparent Diffusion Coefficient Values and Conventional MRI Features in Differentiating Tumefactive Demyelinating Lesions From Primary Brain Neoplasms. (medscape.com)
  • Nuclear medicine, including single-photon emission computed tomography (SPECT) bone scintigraphy, is generally reserved for the presumptive evaluation of infections, metastatic and primary neoplasms, and complex occult trauma. (medscape.com)
  • Smoking is the greatest risk factor for upper aerodigestive cancers (thoracic or head and neck) and negatively impacts survival and other outcomes, but many patients have difficulty quitting after their diagnosis. (clinicaltrials.gov)
  • The text covers the evolution of modern neck dissection, from George Crile in 1906 to current cutting-edge procedures, and details the transition from radical neck dissection to a less aggressive, equally effective approach for treating lymph node metastases in head and neck cancer. (calacademy.org)
  • The relationship between functional and selective neck dissection is discussed from a pragmatic and nonconventional perspective, elucidating the connection from historical, anatomic, and surgical standpoints. (calacademy.org)
  • Preceded by Functional and selective neck dissection / Javier Gavilán [and others]. (calacademy.org)
  • The University of Washington Head and Neck questionnaire version 4 (UW-QOL) and Therapy Outcome Measures (TOM) were rated before and 6 months after cancer treatment in 95 patients from 12 centres. (edgehill.ac.uk)
  • The scientific developments of biologists, physicists and doctors made it possible to treat many previously untreatable diseases, including birthmarks on the face, head, neck and other parts of the body. (beautysummary.com)
  • 30-50% of GCT occur in the head and neck region, with the most common site being the tongue. (surgpath4u.com)
  • Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic manifestations. (uandes.cl)
  • In one of Dr. Gene's most famous facial reconstruction cases, he led a team of surgeons at Methodist Hospital to re-build Carolyn Thomas's face after she was shot in the head. (texasface.com)
  • For example, a broader array of codes has been established to identify where in a patient's body certain neoplasms have occurred, such as the left or right breast or the left or right lung. (onclive.com)
  • CONCLUSION These results verify that MIS on the head and neck can spread significantly beyond the clinical margin and demonstrate the importance of confirming clearance histologically before closure procedures. (elsevier.com)
  • Conclusion The above data confirm safety and feasibility of VSV-IFN-β administration in immunocompetent animals and support its clinical evaluation in advanced human head and neck cancer. (elsevier.com)
  • Adaptation of TOM scales for use with head and neck cancer patients may improve sensitivity, validity and therapist compliance. (edgehill.ac.uk)
  • Patients: One hundred five patients with head and neck cancer undergoing ND after CRT. (illinois.edu)
  • Can energy expenditure estimates from bio-impedance equipment replace estimates by harris-benedict in patients with head and neck cancer? (hanze.nl)
  • They are partially responsible for the limited improvement in survival of head and neck cancer during the past 20 years. (nih.gov)
  • Rad51C: a novel suppressor gene modulates the risk of head and neck cancer. (cdc.gov)
  • Speech and swallowing are important components of health-related quality of life following head and neck cancer treatment. (edgehill.ac.uk)
  • BACKGROUND: Plasma cell neoplasms are characterized by the proliferation of a single clone of plasma cells with production of a monoclonal immunoglobulin. (uandes.cl)
  • Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. (vanderbilt.edu)
  • Background: Genetic studies of salivary gland neoplasms including pleomorphic adenomas (PA) were mainly focused on chromosomal changes and several specific patterns of chromosome translocations have been described. (ac.rs)
  • Double board-certified facial plastic surgeon Dr. Eugene 'Gene' Alford is one of the few doctors with experience in Total Facial Reconstruction, which means he's capable of replacing the entire face of a patient disfigured by a severe burn, accident, cancer of the head and neck, or other reasons. (texasface.com)
  • During this time oversaw all manners of complex spinal problems including congenital, traumatic, pathological and neoplasms of the spine. (trustwellhospitals.com)
  • Classical skin lesion of BCC is an asymptomatic papule or nodule with pearly, rolled border, located over the head and face [Figure 1]. (cdriadvlkn.org)
  • The head CT demonstrates multiple, bilateral, patchy foci of hypo attenuation within the subcortical white matter with some minimal cortical involvement of the occipital, anterior parietal, and posterior frontal lobes. (blogspot.com)
  • Keywords: vaccination campaigns, anti-HPV vaccine, Human papillomavirus Cancerul de virus papiloma humano puede tener hijos uterin rămâne cea mai răspândită formă de neoplasm produsă de virusul HPV şi al patrulea cel mai frecvent tip de afecţiune malignă la persoanele de sex feminin. (adventube.ro)
  • Was the head of the specialized spine and arthroplasty unit in the department of orthopaedics from November 2015. (trustwellhospitals.com)
  • They are usually located on the back of the head and neck, do not need treatment and pass on their own during the first year of life. (beautysummary.com)