Syndecan-1 expression has prognostic significance in head and neck carcinoma. (1/5027)

The syndecans are a family of cell-surface heparan sulphate proteoglycans that regulate cell behaviour by binding extracellular matrix molecules such as growth factors. The syndecan family has four members, of which syndecan-1 is the most studied and best characterized. We have studied the prognostic significance of syndecan-1 expression in squamous cell carcinoma (SCC) of the head and neck treated with surgery and post-operative radiotherapy. Paraffin-embedded tissue samples taken from 175 patients with primary SCC, followed up from 2 to 15 years after surgery, were studied for expression of syndecan-1 by immunohistochemistry. A low number (< or =50%, the median value) of syndecan-1-positive tumour cells was associated with low histological grade of differentiation (P<0.0001), a large primary tumour size (T1-2 vs. T3-4, P = 0.02), positive nodal status (NO vs. N1-3, P = 0.0006), and high clinical stage (stage I or II vs. III or IV, P<0.0001). Low syndecan-1 expression was also associated with unfavourable overall survival in a univariate analysis (P = 0.001). In a multivariate survival analysis, the clinical stage and syndecan-1 expression were the only independent prognostic factors. We conclude that syndecan-1 is a novel prognostic factor in SCC of the head and neck treated with surgery and post-operative radiotherapy.  (+info)

[3H]gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell line. (2/5027)

Cellular uptake of many chemotherapeutic nucleoside analogs is dependent on the activity of a family of nucleoside transport proteins located in the cell plasma membrane. In the present study, we examined the role of these transporters in the accumulation of gemcitabine by a human head and neck squamous carcinoma cell line. The uptake of [3H]gemcitibine was compared with that of [3H]uridine and [3H]formycin B in the parent cell line (HN-5a) and in a gemcitabine-resistant variant (GEM-8e). The HN-5a and GEM-8e cells were similar in their transport characteristics and expressed predominantly the es (equilibrative, inhibitor-sensitive) transporter subtype; less than 10% of the influx of [3H]formycin B or [3H]uridine was mediated by the ei (equilibrative inhibitor-resistant) system, and there was no evidence for Na+-dependent nucleoside transporters. [3H]Gemcitabine (10 microM) entered these cells via both the es and ei transporters with an initial rate of uptake similar to that seen with the use of [3H]formycin B or [3H]uridine. In addition, ATP-replete cells accumulated significantly less [3H]gemcitabine than did ATP-depleted cells, which is indicative of an active efflux mechanism for gemcitabine. These results show that gemcitabine is a substrate for both the es and ei nucleoside transporters of HN-5a and GEM-8e cells and that gemcitabine resistance of the GEM-8e cells cannot be attributed to changes in transporter activity. Further studies to define the characteristics of the putative efflux mechanism are clearly warranted because this system has the potential to significantly affect the clinical efficacy of gemcitabine.  (+info)

Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer. (3/5027)

5-Fluorouracil (5-FU) is an effective enhancer of radiation therapy (RT) in head and neck cancers. Due to rapid, predominantly hepatic metabolism by dihydropyrimidine dehydrogenase (DPD) and suggested clinical benefit from prolonged drug exposure, 5-FU is commonly given by continuous infusion. Eniluracil is a novel DPD-inactivator designed to prolong the half-life of 5-FU and provide sustained plasma concentrations of 5-FU with oral dosing. We conducted a Phase I study of the safety and efficacy of eniluracil given with oral 5-FU in patients receiving concurrent RT for recurrent or advanced squamous cell carcinomas of the head and neck. Thirteen patients with recurrent, metastatic, or high-risk (defined as an expected 2-year survival rate of <10%) head and neck cancer were enrolled and treated with concomitant chemoradiotherapy on an every-other-week schedule. Eniluracil at a fixed dose [20 mg twice a day (BID)] was given for 7 consecutive days (days 1-7). 5-FU and RT were given on 5 consecutive days (days 2-6). One patient was treated with once-daily RT (2.0 Gy fractions). The remaining patients received hyperfractionated RT (1.5-Gy fractions BID). The initial dose of 5-FU was 2.5 mg/m2 given BID. Dose escalation in patient cohorts was scheduled at 2.5-mg/m2 increments, with intrapatient dose escalation permitted. Lymphocyte DPD activity and serum 5-FU and uracil concentrations were monitored during two cycles. DPD activity was completely or nearly completely inactivated in all patients. Sustained, presumed therapeutic concentrations of 5-FU were observed at a dose of 5.0 mg/m2 given BID. Cumulative dose-limiting myelosuppression (both neutropenia and thrombocytopenia) was observed during the fourth and fifth cycles following administration of 5.0 mg/m2 5-FU BID. One patient died of neutropenic sepsis during cycle 4. Other late cycle toxicities included diarrhea, fatigue, and mucositis. Grade 3 mucositis was observed in 4 patients, but no grade 4 mucositis or grade 3 or 4 dermatitis was observed. A second patient death occurred during cycle 1 of treatment. No specific cause of death was identified. The study was subsequently discontinued. Cumulative myelosupression was the significant dose-limiting toxicity of oral 5-FU given with the DPD-inactivator eniluracil on an every-other-week schedule. Clinical radiation sensitization was not observed, based on the absence of dose-limiting mucositis and dermatitis. Alternative dosing schedules need to be examined to determine the most appropriate use of eniluracil and 5-FU as radiation enhancers.  (+info)

Clinical significance of decreased zeta chain expression in peripheral blood lymphocytes of patients with head and neck cancer. (4/5027)

Patients with squamous cell carcinoma of the head and neck (SCCHN) frequently have impaired immune responses. Alterations in T-cell receptor-associated signaling molecules in tumor-infiltrating as well as circulating lymphocytes have been reported in these patients. Using quantitative flow cytometry analysis, we have demonstrated that expression of the zeta chain is significantly decreased relative to normal controls in both CD8+ and CD4+ T cells as well as CD3- CD56+ CD16+ natural killer cells in the peripheral blood of patients with SCCHN who, as a result of previous therapies, have no evident disease. Patients with a more aggressive type of SCCHN and those who experienced a recurrence or had a second primary cancer within the last 2 years of the study had the lowest zeta chain expression. In addition, SCCHN patients showed a significantly greater spontaneous ex vivo apoptosis, as measured by a terminal deoxynucleotide transferase-mediated dUTP nick end labeling assay, in PBMCs, compared to normal controls. The observed decreased expression of zeta in T and natural killer cells coincided but did not directly correlate with significantly increased spontaneous apoptosis of lymphocytes obtained from treated patients with no evident disease. The results suggest that in patients with SCCHN, zeta chain defects and lymphocyte apoptosis are manifestations of long-lasting negative effects of tumor on the immune system.  (+info)

Expression of apoptosis-related genes in human head and neck squamous cell carcinomas undergoing p53-mediated programmed cell death. (5/5027)

Human head and neck squamous cell carcinoma (HNSCC) lines infected with a replication-defective Ad5CMV-p53 vector bearing a wild-type human p53 gene were used to examine alterations in the production of proteins implicated in regulating apoptosis. Because HNSCC lines express abundant levels of c-myc, and simultaneous expression of c-myc and p53 is known to trigger apoptosis in other cells, cooperation between these two genes was examined. Surprisingly, levels of c-myc mRNA and protein were rapidly and profoundly suppressed after infection with wild-type p53. Suppression of c-myc using antisense oligodeoxynucleotides (in the absence of p53) was sufficient to trigger apoptosis in Tu-138 cells, raising the possibility that the reduction of c-myc may be involved in at least one of the cell death pathways mediated by p53. Expression of a panel of Bcl-2 homology proteins was also examined in HNSCC lines undergoing p53-mediated apoptosis. No changes in Bcl-2, Bak, or Bcl-xS were found after p53 expression. Increased levels of the apoptosis-accelerating protein Bax were found in HNSCC lines after infection with Ad5CMV-p53. Induction of the apoptosis-inhibiting protein Bcl-xL was observed in Tu-167 cells and may account for the delayed onset of apoptosis in these cells. These studies suggest that multiple pathways may regulate apoptosis after transient overexpression of p53.  (+info)

The contribution of DNA ploidy to radiation sensitivity in human tumour cell lines. (6/5027)

The contribution of DNA ploidy to radiation sensitivity was investigated in a group of eight human tumour cell lines. As previous studies suggest, while more aneuploid tumours tend to be more radioresistant, there is no significant relationship between ploidy and radiation sensitivity (SF2). The failure to observe a significant effect of ploidy on radiation sensitivity is due to the complex and multifactorial basis of radiation sensitivity. When we determined the relationship between survival and radiation-induced chromosome aberration frequency, a measure independent of most other modifiers of sensitivity, we observed a direct relationship between ploidy and mean lethal aberration frequency. The mean lethal frequency of aberrations increased from about 1 for diploid cells to about 2 for tetraploid cells. The mean lethal frequency of aberrations was independent of DNA repair variations. These observations demonstrate that changes in DNA ploidy are an important contributor to radiation sensitivity variations in human tumour cell lines. Therefore, any battery of predictive assays should include DNA ploidy measurements.  (+info)

Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. (7/5027)

The purpose of this study was to determine whether cyclooxygenase-2 (COX-2) was overexpressed in squamous cell carcinoma of the head and neck (HNSCC). Quantitative reverse transcription-PCR, immunoblotting, and immunohistochemistry were used to assess the expression of COX-2 in head and neck tissue. Mean levels of COX-2 mRNA were increased by nearly 150-fold in HNSCC (n = 24) compared with normal oral mucosa from healthy volunteers (n = 17). Additionally, there was about a 50-fold increase in amounts of COX-2 mRNA in normal-appearing epithelium adjacent to HNSCC (n = 10) compared with normal oral mucosa from healthy volunteers. Immunoblotting demonstrated that COX-2 protein was present in six of six cases of HNSCC but was undetectable in normal oral mucosa from healthy subjects. Immunohistochemical analysis showed that COX-2 was expressed in both HNSCC and adjacent normal-appearing epithelium. Taken together, these results suggest that COX-2 may be a target for the prevention or treatment of HNSCC.  (+info)

Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35. (8/5027)

PURPOSE: The aim of this study was to define the scales and test the validity, reliability, and sensitivity of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-H&N35, a questionnaire designed to assess the quality of life of head and neck (H&N) cancer patients in conjunction with the general cancer-specific EORTC QLQ-C30. PATIENTS AND METHODS: Questionnaires were given to 500 H&N cancer patients from Norway, Sweden, and the Netherlands as part of two prospective studies. The patients completed the questionnaires before, during (Norway and Sweden only), and after treatment, yielding a total of 2070 completed questionnaires. RESULTS: The compliance rate was high, and the questionnaires were well accepted by the patients. Seven scales were constructed (pain, swallowing, senses, speech, social eating, social contact, sexuality). Scales and single items were sensitive to differences between patient subgroups with relation to site, stage, or performance status. Most scales and single items were sensitive to changes, with differences of various magnitudes according to the site in question. The internal consistency, as assessed by Cronbach's alpha coefficient, varied according to assessment point and within subsamples of patients. A low overall alpha value was found for the speech and the senses scales, but values were higher in assessments of patients with laryngeal cancer and in patients with nose, sinus, and salivary gland tumors. Scales and single items in the QLQ-H&N35 seem to be more sensitive to differences between groups and changes over time than do the scales and single items in the core questionnaire. CONCLUSION: The QLQ-H&N35, in conjunction with the QLQ-C30, provides a valuable tool for the assessment of health-related quality of life in clinical studies of H&N cancer patients before, during, and after treatment with radiotherapy, surgery, or chemotherapy.  (+info)

Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... Many cutaneous neoplasms occur in the setting of systemic syndromes. List of cutaneous conditions List of contact allergens ...
Updated: Jan 13, 2021 Diagrams by Mikael Häggström, MD Thompson LD (2016). Diagnostic Pathology: Head and Neck (2nd ed.). ... Lee SC (22 December 2022). "Salivary Gland Neoplasms". Medscape. ... Head and Neck Pathology. 10 (2): 152-160. doi:10.1007/s12105- ...
Mar 2012). "Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data". Head Neck ... Steve C Lee, MD, PhD (22 December 2022). "Salivary Gland Neoplasms". Medscape.{{cite journal}}: CS1 maint: multiple names: ... Head Neck Pathol. 7 Suppl 1: S68-76. doi:10.1007/s12105-013-0454-z. PMC 3712089. PMID 23821206. Antony, J.; Gopalan, V.; Smith ...
Head & Neck. 39 (2): 387-391. doi:10.1002/hed.24564. PMID 27550745. S2CID 3758029. McGurk M, Thomas BL, Renehan AG (November ... Benign neoplasms, Salivary gland neoplasia, Connective and soft tissue neoplasms). ... Otolaryngology-Head and Neck Surgery. 129 (6): 726-732. doi:10.1016/j.otohns.2003.07.009. PMID 14663442. S2CID 24528326. Steve ... Otolaryngology-Head and Neck Surgery. 133 (3): 319-322. doi:10.1016/j.otohns.2005.04.008. PMID 16143173. S2CID 38480631. Ganly ...
Mino M, Pilch BZ, Faquin WC (December 2003). "Expression of KIT (CD117) in neoplasms of the head and neck: an ancillary marker ... "Treatment of salivary gland neoplasms with fast neutron radiotherapy". Arch. Otolaryngol. Head Neck Surg. 129 (9): 944-8. doi: ... The head, neck, mouth, and throat will be checked for signs of disease, such as lumps or anything else that seems unusual. A ... Head and neck cancer Salivary gland pathology Zaleski, Michael P.; Kalhor, Neda; Moran, Cesar A. (November 2020). "Mucous Gland ...
"Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas". Modern Pathology. 15 (3): 264-278. ... A neuroectodermal neoplasm is a neoplasm or tumor of the neuroectoderm. They are most commonly tumors in the central or ... They include pituitary adenoma and carcinoid tumor Group II tumors/neoplasms: nonepithelial neuroectodermal neoplasms. These ... Group I tumors/neoplasms: neuroendocrine carcinomas. These show predominantly epithelial differentiation. ...
"Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas". Modern Pathology. 15 (3): 264-78. ... Melanoma is a type of neuroectodermal neoplasm. There are four main types of melanoma: Other histopathologic types are: Mucosal ... denoting a tissue mass and especially a neoplasm), in turn from Greek μέλας melas, "dark", and -ωμα oma, "process". The word ...
Lester D. R. Thompson; Bruce M. Wenig (2011). Diagnostic Pathology: Head and Neck: Published by Amirsys. Hagerstown, MD: ... A ceruminous adenoma is a benign glandular neoplasm which arises from the ceruminous glands located within the external ... Head Neck Pathol. 3 (1): 1-17. doi:10.1007/s12105-008-0095-9. PMC 2807538. PMID 20596983. Torske KR, Thompson LD (May 2002). " ... Durko T, Danilewicz M, Pajor A (2003). "[Glandular neoplasms of the external auditory canal--clinical and morphologic ...
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... Overall, 51.5% of their tumors were in the head and neck areas (most commonly the tongue, followed by the larynx, gums, ...
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... the head and neck areas. As defined by microscopic histopathology analyses, GCF tumors consist of a few spindle- and/or ...
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ...
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... Connective and soft tissue neoplasms, Benign neoplasms, Cancer). ... FMTs are a heterogeneous group of soft tissue neoplasms (i.e. ... Clarke LE (October 2012). "Fibrous and fibrohistiocytic neoplasms: an update". Dermatologic Clinics. 30 (4): 643-56, vi. doi: ... in the deep subcutaneous tissue at pressure points or bone prominences but more recently has been found to be a benign neoplasm ...
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ...
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... head, neck, extremities, or abdominal regions. In one study, the tumors ranged form 0.3 to 12 cm in greatest dimension (mean: ... Chokoeva AA, Patterson JW, Tchernev G (December 2017). "Giant Subcutaneous Solitary Gardner Fibroma of the Head of a Bulgarian ... Connective and soft tissue neoplasms, Benign neoplasms). ...
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... The incidence of mammary desmoid tumors is less than 0.2% of primary breast neoplasms. In Gardner's syndrome, the incidence ... List of cutaneous conditions List of dental abnormalities associated with cutaneous conditions List of cutaneous neoplasms ...
December 2015). "Rhabdomyoblastic Differentiation in Head and Neck Malignancies Other Than Rhabdomyosarcoma". Head and Neck ... Neoplasia, the formation of a neoplasm, can result in the expression of tumors and ultimately progress into cancers. The ... Rhabdomyoblastic differentiation has been detected in several other malignancies associated with the head and neck area. ... Pleuropulmonary blastoma development occurs in children; its presentation can occur via pulmonary or pleural based neoplasms. ...
Stafne defect Barnes L (2008). Surgical pathology of the head and neck (3rd ed.). New York: Informa Healthcare. pp. 477-478. ... Salivary gland neoplasm occurrence within heterotopic salivary gland tissue is rare. ...
It usually occurs in the neck or head, although cases have been documented in other areas of the body. Most diagnosis occur ... Articles with short description, Short description matches Wikidata, Epidermal nevi, neoplasms, and cysts). ... Head & Neck. 34 (7): 1045-1050. doi:10.1002/hed.21690. PMID 21384456. S2CID 205857529. Retrieved 4 December 2020. ( ... MACs usually present as a smooth, flesh or yellow colored, slow-growing nodule or bump somewhere on the face or neck with ...
Lester D. R. Thompson; Bruce M. Wenig (2011). Diagnostic Pathology: Head and Neck: Published by Amirsys. Hagerstown, MD: ... ISBN 978-1-931884-61-7. (Articles with short description, Short description matches Wikidata, Benign neoplasms, Connective and ... The mass is usually in the neck (hence the name "nuchal-type"), but it can be seen in the extremities, lumbosacral area, ... The most common site is the posterior neck, but may also be seen in other sites (extremities, lumbosacral area, buttocks, face ...
Keat Jin Lee (2003). Essential otolaryngology: head & neck surgery. McGraw-Hill Professional. p. 1052. ISBN 978-0-07-137322-7. ... Matutes E (May 2018). "The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms". International Journal of ... Otolaryngology-Head and Neck Surgery. 114 (4): 653-6. doi:10.1016/s0194-5998(96)70264-4. PMID 8643282. ...
Affected regions include the head and neck region and the upper part of the trunk. It may coexist with certain neoplasms or ...
Some head and neck tumours invade or compress the facial nerve leading to facial paresis or paralysis. Examples of such tumours ... are facial neuromas, cholesteatomas, hemangiomas, acoustic neuromas, parotid gland neoplasms or metastases. Sometimes, the ... Tate JR, Tollefson TT (August 2006). "Advances in facial reanimation". Curr Opin Otolaryngol Head Neck Surg. 14 (4): 242-8. doi ... Otolaryngol Head Neck Surg. 141 (1): 139-41. doi:10.1016/j.otohns.2009.03.005. PMID 19559974. S2CID 21895398. Faria JC, Scopel ...
... of all head and neck cancers. The root of the word parotidectomy, parotid, refers to the parotid gland meaning "situated near ... Typically performed if neoplasm is affecting deep part of parotid gland. Surgeon tries to remove the gland apart from the ... Benign parotid gland neoplasms typically present after the age of 40 and have an equal presentation in both genders. Malignant ... Neoplasms can be benign (non-cancerous) or malignant (cancerous). The majority of parotid gland tumors are benign, however 20% ...
Kum YS, Kim JK, Cho CH, Kim HK (2009). "Intraneural reticular perineurioma of the hypoglossal nerve". Head & Neck. 31 (6): 833- ... A clonal neoplasm associated with abnormalities of chromosome 22". Am J Clin Pathol. 103 (6): 696-704. doi:10.1093/ajcp/103.6. ... a distinctive and underrecognized peripheral nerve sheath neoplasm". Archives of Pathology & Laboratory Medicine. 131 (4): 625- ...
... s are 2 to 4 mm in diameter, dome-shaped, yellowish or skin-colored papules usually located on the head, neck, ... ISBN 0-7216-2921-0. v t e (Epidermal nevi, neoplasms, and cysts, All stub articles, Epidermal nevi, neoplasm, cyst stubs). ... They are characteristically seen in Birt-Hogg-Dubé syndrome.: 674 List of cutaneous conditions List of cutaneous neoplasms ...
... usually located on the head and neck.: 669 Mucinous carcinoma of the breast: Gross pathology (upper left) of mucinous carcinoma ... A mucinous neoplasm (also called colloid neoplasm) is an abnormal and excessive growth of tissue (neoplasia) with associated ... neoplasms, and cysts, All stub articles, Oncology stubs, Epidermal nevi, neoplasm, cyst stubs). ... A malignant mucinous neoplasm is called a mucinous carcinoma. For example, for ovarian mucinous tumors, approximately 75% are ...
In one large study, this presentation was accompanied by swollen lymph nodes, usually in the neck, due to malignant pDC ... and/or ulcers that most often occur on the head, face, and upper torso. The lesions are due to diffuse infiltrations of the ... The neoplasm occurs in individuals of all ages but predominates in the elderly; in children, it afflicts males and females ... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy. It was initially regarded as a form of ...
These epigenetic defects occurred in various cancers (e.g. breast, ovarian, colorectal and head and neck). Two or three ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... Tawfik HM, El-Maqsoud NM, Hak BH, El-Sherbiny YM (2011). "Head and neck squamous cell carcinoma: mismatch repair ... The word neoplasm is from Ancient Greek νέος- neo 'new' and πλάσμα plasma 'formation, creation'. A neoplasm can be benign, ...
Treatment of Salivary Gland Neoplasms with fast neutron Radiotherapy. Arch Otolaryngol Head Neck Surg Vol 129 944-948 Sep 2003 ... Various other head and neck tumors have been examined. No cancer therapy is without the risk of side effects. Neutron therapy ... For instance, some of the most remarkable cures it has been able to achieve are with cancers of the head and neck. Many of ... The treatment of recurrence following fast neutron therapy for head and neck malignancy. Clin Otolaryngol Allied Sci. 1996 Jun; ...
A paraganglioma is a rare neuroendocrine neoplasm that may develop at various body sites (including the head, neck, thorax and ... Head and neck paraganglioma (HNPGL): There are various types of head and neck paraganglioma; they may have specialized names ... Vagal paraganglioma: These are the least common of the head and neck paragangliomas. They usually present as a painless neck ... Is the most common of the head and neck paragangliomas. It usually presents as a painless neck mass, but larger tumors may ...
Head and Neck Pathology. 15 (1): 212-224. doi:10.1007/s12105-020-01193-5. PMC 8010008. PMID 32562215. Gong P, Xia C, Yang Y, ... is a slow growing salivary gland neoplasm (the SG in MASCSG stands for salivary gland) that develops in adults and, in a ... Head & Neck. 39 (6): 1243-1248. doi:10.1002/hed.24755. PMID 28370824. S2CID 3073024. Skálová A, Vanecek T, Sima R, Laco J, ... Head and Neck Pathology. 13 (4): 562-572. doi:10.1007/s12105-018-0995-2. PMC 6854196. PMID 30564997. Baneckova M, Agaimy A, ...
Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.  Zhou, ... Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck.  Yu, ... Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung ... Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision ...
Head and Neck Neoplasms. Study of Pembrolizumab or Placebo With Chemoradiation in Participants With Locally Advanced Head and ... Condition: Head and Neck Neoplasms. The purpose of this study is to determine the efficacy and safety of pembrolizumab given ... and as maintenance therapy versus placebo plus CRT in participants with locally advanced head and neck squamous cell carcinoma ... of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck ...
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... Many cutaneous neoplasms occur in the setting of systemic syndromes. List of cutaneous conditions List of contact allergens ...
Management of thyroid neoplasms. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck ... You may have some pain and soreness in your neck at first, especially when you swallow. Your voice may be a little hoarse for ... Keep your head raised while you are sleeping for the first week. ...
The reemergence of a malignant head and neck neoplasm after a period of remission. ... Head and Neck Disorder*Head and neck neoplasm*Head and neck cancer*Recurrent Malignant Head and Neck Neoplasm*Recurrent Head ... Recurrent Malignant Head and Neck Neoplasm Recurrent Malignant Head and Neck Neoplasm. ... Recurrent Head and Neck Squamous Cell Carcinoma*Locally Recurrent Head and Neck Squamous Cell Carcinoma ...
A quarter of all extranodal lymphomas occur in the head and neck, and 8% of findings on supraclavicular fine-needle aspirate ... The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016 May 19. 127 (20):2375-90. ... Head and Neck Cancer - Resection and Neck Dissection * Microarray Technologies in the Diagnosis and Treatment of Head and Neck ... encoded search term (Lymphomas of the Head and Neck) and Lymphomas of the Head and Neck What to Read Next on Medscape ...
Endoscopic ultrasonography in the diagnosis and staging of neoplasms of the head and neck. / Wildi, S. M.; Fickling, W. E.; Day ... Endoscopic ultrasonography in the diagnosis and staging of neoplasms of the head and neck. In: Endoscopy. 2004 ; Vol. 36, No. 7 ... Endoscopic ultrasonography in the diagnosis and staging of neoplasms of the head and neck. Endoscopy. 2004 Jul 1;36(7):624-630 ... Dive into the research topics of Endoscopic ultrasonography in the diagnosis and staging of neoplasms of the head and neck. ...
Treatment Otolaryngology-Head and Neck Surgery, 4e online now, exclusively on AccessSurgery. AccessSurgery is a subscription- ... "Neck Neoplasms and Neck Dissection." Current Diagnosis & Treatment Otolaryngology-Head and Neck Surgery, 4e Lalwani AK. Lalwani ... Neoplasms of the head and neck may be benign or malignant. Benign tumors can arise from soft tissue in the neck including fat, ... Cracchiolo J.R., & Wong R.J. Cracchiolo, Jennifer R., and Richard J. Wong.Neck Neoplasms and Neck Dissection. In: Lalwani AK. ...
... findings challenge the common belief that pain results from tissue compression or IL-1 signaling in patients with head and neck ... Oropharyngeal Neoplasms / complications* * Oropharyngeal Neoplasms / metabolism * Oropharyngeal Neoplasms / virology * Pain ... A Novel Syngeneic Immunocompetent Mouse Model of Head and Neck Cancer Pain Independent of Interleukin-1 Signaling Anesth Analg ... Background: Pain is one of the first presenting symptoms in patients with head and neck cancer, who often develop chronic and ...
Muir-Torre syndrome (MTS) is the combination of neoplasms of the skin (usually sebaceous adenoma, sebaceous epithelioma, or ... Arch Otolaryngol Head Neck Surg. 2007 Aug. 133(8):820-6. [QxMD MEDLINE Link]. ... Sebaceous neoplasms, with the exception of sebaceous hyperplasia and nevus sebaceus of Jadassohn, are rare and should signal ... Lee BA, Yu L, Ma L, Lind AC, Lu D. Sebaceous neoplasms with mismatch repair protein expressions and the frequency of co- ...
Head and Neck Neoplasms / pathology* * Head and Neck Neoplasms / surgery * Head and Neck Neoplasms / therapy ... It recurred on the neck area 4 months after excision and the lesion was removed with surgical resection again. There was ...
T1 - Head and Neck Mesenchymal Neoplasms With GLI1 Gene Alterations. T2 - A Pathologic Entity With Distinct Histologic Features ... Head and Neck Mesenchymal Neoplasms With GLI1 Gene Alterations: A Pathologic Entity With Distinct Histologic Features and ... Head and Neck Mesenchymal Neoplasms With GLI1 Gene Alterations: A Pathologic Entity With Distinct Histologic Features and ... Head and Neck Mesenchymal Neoplasms With GLI1 Gene Alterations: A Pathologic Entity With Distinct Histologic Features and ...
Information about the SNOMED CT code 95001001 representing Neoplasm of uncertain behavior of pharynx. ... Finding of head and neck region 118254002. Mass of head and/or neck 274751001. Tumor of head and neck 255055008. Neoplasm of ... Finding of head and neck region 118254002. Mass of head and/or neck 274751001. Mass of pharynx 71731000112108. Neoplasm of ... Finding of head and neck region 118254002. Mass of head and/or neck 274751001. Mass of pharynx 71731000112108. Neoplasm of ...
The purpose of this study is to elucidate the association between PM2.5 and oral neoplasm, including oral potentially malignant ... Chaturvedi, A.K. (2012). Epidemiology and clinical aspects of HPV in head and neck cancers. Head Neck Pathol. 6, 16-24. https ... The Association between Ambient Fine Particulate Matter and Oral Neoplasm among Smokers and Betel Quids Chewers Details 2021 - ... 2. Geographically gradients of oral neoplasms by county/city. (a) rate (%) of OPMD and OC cases (b) rate (%) of OPMD cases (c) ...
... head-and-neck squamous cell carcinoma; HCC, hepatocellular carcinoma; LS, liposarcoma; LobCa, lobular carcinoma; Lymph. BNHL, ... CLL, lymphoid chronic lymphocytic leukemia; MPN, myeloproliferative neoplasm; Panc. endocrine, pancreatic neuroendocrine tumour ... DEL, deletion-like rearrangement; DUP, duplication-like rearrangement; h2hINV, head-to-head inversion; t2tINV, tail-to-tail ... AdC, adenocarcinoma; CNS GBM, central nervous system glioblastoma; CNS medullo., central nervous system medulloblastoma; Head ...
7819 Benign skin neoplasms: Rate as disfigurement of the head, face, or neck (DC 7800), scars (DCs 7801, 7802, 7803, 7804, or ... or neck; scar(s) of the head, face, or neck due to other causes; or other disfigurement of the head, face, or neck: ... 7818 Malignant skin neoplasms (other than malignant melanoma): Rate as disfigurement of the head, face, or neck (DC 7800), ... 7802 Burn scar(s) or scar(s) due to other causes, not of the head, face, or neck, that are not associated with underlying soft ...
Urinary System Neoplasms (5) * Head & Neck Neoplasms (2) * Skin Cancer & Excision (1) ...
Oropharyngeal Neoplasms/pathology, Head and Neck Neoplasms, Papillomavirus Infections/metabolism, Cyclin-Dependent Kinase ... Oropharyngeal Neoplasms/pathology; Head and Neck Neoplasms; Papillomavirus Infections/metabolism; Cyclin-Dependent Kinase ... Humans, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell/pathology, Tumor Burden, ... have advanced our understanding of fundamental radiobiological characteristics in head and neck squamous cell carcinoma (HNSCC ...
Neoplasms. Head and Neck Surgery. Skull Base Surgery. Tracheotomy. Zenker Diverticulum. Summary. Discussion Questions. Study ... Neck Surgery Department at The Ohio State University as a tenured Professor in Otolaryngology - Head & Neck Surgery in April ... The Comprehensive Skull Base Surgery Program is part of the Head & Neck Oncology Division at The James Cancer Hospital and the ... Preventative Swallowing Therapy for Head and Neck Cancer Survivors. Other Swallowing Treatment Methods. Summary. Discussion ...
Head and Neck Neoplasms. *Neoplasm Metastasis. *Neoplasms. *Neoplasms, Second Primary. .map{width:100%;height:300px;margin- ... Ineligible to receive radiotherapy to head and neck during study. - Primary intraoral lesions must be measurable and accessible ... To Express A Triad Of Co-Stimulatory Molecules In Patients With Advanced Squamous Cell Carcinoma Of The Head And Neck. Trial ... Deep neck muscles. - Carotid artery (requiring resection). - Nasopharynx and/or pterygoid muscles. - ...
Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ... List of cutaneous neoplasms associated with systemic syndromes. References[edit]. .mw-parser-output .reflist{font-size:90%; ... The incidence of mammary desmoid tumors is less than 0.2% of primary breast neoplasms. In Gardners syndrome, the incidence ...
Categories: Head and Neck Neoplasms Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
NEOPLASMS: Malignant, Surgery of advanced cancer of the head and neck, with immediate reconstruction employing flaps from the ... NECK: Neoplasms, Combined approach for massive nasopharyngeal fibroma. Rege, S. R.; Shah, K. L.; Kantawala, S. A.; More ... HEAD: Lips, A contribution to the primary reconstruction of the upper lip and labial commissure following tumor excision. G, ... NEOPLASMS: Malignant, Adeno-cystic carcinoma of the scalp with pulmonary metastasis. Sanderson, K. V.; Batten, J. C.; Wood, ...
Malignant neoplasms of other and unspecified parts of the mouth is an ailment of the human body ... Malignant neoplasms of other and unspecified parts of the mouth is an ailment of the human body ... Malignant neoplasms of other and unspecified parts of the mouth. ICD9. 140-149. ICD10. C00-C14. Affected Organs. * Head & neck ...
Chapter 6. Cysts and neoplasms of the Mandible and Maxilla. Brett Miles, MD¹ and Tara Aghaloo, MD². ¹Department of ... Essential Head and Neck Oncology and Surgery. $145.00. - $229.00. Maie A. St. John, MD, PhD, FACS - Department of Head and Neck ... NCCN Head and Neck Guideline Overview. Saral Mehra, MD, MBA, FACS; and Babak Givi, MD. Head and Neck Surgery, Surgical Oncology ... ²Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, USA. ³Department of Head and Neck ...
Head and Neck Neoplasms. Chapter 42. Benign Skin Lesions. Tzyy-Nong Liou, Wee Tin K. Kao, Samuel Hahn, and Gregory H. Branham ... Congenital Vascular Lesions of the Head and Neck. Tara E. Brennan, Teresa O, and Milton Waner ... It is formatted in a very similar way to the well-known Otolaryngology - Head and Neck Surgery by Pasha. The book is organised ... Formatted like the bestselling Pasha (Otolaryngology-Head and Neck Surgery) pocket guide, this text provides a condensed ...
Head and Neck Neoplasms. *Radiation Injuries. .map{width:100%;height:300px;margin-bottom:15px;} Name. Location. ... the head and neck Unresectable disease. PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 OR Karnofsky. 70 ... since prior radiotherapy (patients with recurrent disease) to head and neck region. Surgery: Not speciified Other: At least 24 ... concurrent chemoradiotherapy in advanced, previously irradiated or metastatic head and neck. cancer. II. Determine the toxicity ...
Head and Neck Neoplasms. *Melanoma. *Skin Neoplasms. *Ultraviolet Rays. *Wound Healing. *Mohs Surgery ...
  • BACKGROUND: Analyses of clinical outcomes following radiotherapy (RT) have advanced our understanding of fundamental radiobiological characteristics in head and neck squamous cell carcinoma (HNSCC). (lu.se)
  • Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
  • Professor and Head of TYKS's Department of Oncology and Radiotherapy, where he started in 1985. (philips.com)
  • Objective To evaluate the ability to open the mouth in patients undergoing radiotherapy for head and neck and the variables related to this limitation. (bvsalud.org)
  • Methods 32 patients were evaluated six months after completion of radiotherapy sessions to treat cancer in the head and neck. (bvsalud.org)
  • Acinic cell carcinoma (ACC) makes up about 6.5% of all salivary gland neoplasms and roughly 18% of all malignant neoplasms of the salivary glands . (webpathology.com)
  • Minor salivary gland neoplasms are often difficult to assess on examination, and the use of preoperative CT scanning or MRI is important for determining the extent of tumor, which is otherwise not clinically appreciable. (medscape.com)
  • This imaging is particularly valuable for salivary gland neoplasms in the paranasal sinus, where skull-base or intracranial extension may alter the resectability of the tumors. (medscape.com)
  • F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scanning can be used to plan treatment of salivary gland malignancies by detecting lymph node metastases that require a neck dissection or by finding distant metastases that may not have caused abnormalities in routine blood work. (medscape.com)
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • Some common salivary gland neoplasms are listed in the image below. (medscape.com)
  • Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
  • [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 1.5 cases per 100,000 individuals in the United States. (medscape.com)
  • Salivary gland neoplasms most commonly appear in the sixth decade of life. (medscape.com)
  • Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. (medscape.com)
  • Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
  • Salivary gland neoplasms are rare in children. (medscape.com)
  • In children, 35% of salivary gland neoplasms are malignant. (medscape.com)
  • The etiology of salivary gland neoplasms is not fully understood. (medscape.com)
  • Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)
  • This disease has peculiarities in its etiopathogenesis, presentation, risk of nodal and distant metastasis, response to therapy and overall survival (OS) outcomes that stand out as compared to other head and neck cancer subsites. (intechopen.com)
  • Various central nervous system neoplasms have been associated with familial nonpolyposis gut carcinoma, and appropriate imaging should be performed in the presence of suggestive signs or symptoms. (medscape.com)
  • The most common malignant neoplasm is metastatic cancers arising from the upper aerodigestive tract, skin, or thyroid. (mhmedical.com)
  • Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites. (duke.edu)
  • With a provisional clinical diagnosis of benign neoplasm, the lesion was surgically excised under local anaesthesia, using a diode laser with a 300 μm fibre and operating at 2,5 W. Direct suture of the surgical margins was unnecessary as no bleeding was observed during and following the excision (Fig. 2 ). (springer.com)
  • The hemangioma, Lymphangiomas and cystic hygroma in children, are the widespread benign neoplasm. (benthamscience.com)
  • Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment. (nih.gov)
  • Macfarlane, TV, Murchie, P & Watson, MC 2015, ' Aspirin and other non-steroidal anti-inflammatory drug prescriptions and survival after the diagnosis of head and neck and oesophageal cancer ', Cancer Epidemiology , vol. 39, no. 6, pp. 1015-1022. (bath.ac.uk)
  • Indeed, a study by Mamlouk et al of pediatric patients with parotid neoplasms indicated that on MRI scans, the presence not only of poorly defined borders but also of a hypointense T2 signal, restricted diffusion, and focal necrosis are suggestive of malignancy, although not specific for it. (medscape.com)
  • For most small parotid neoplasms without clinical evidence of facial nerve involvement, no pretreatment imaging studies are required. (medscape.com)
  • Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
  • The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the image below. (medscape.com)
  • Common parotid neoplasms. (medscape.com)
  • Little information is available regarding the use of EUS-FNA to stage tumors in the head and neck region. (elsevierpure.com)
  • Patients and Methods: The records of patients who underwent EUS for diagnosis and/or staging of head and neck tumors were reviewed. (elsevierpure.com)
  • Conclusions: EUS with FNA provides a viable approach to the diagnosis and staging of tumors in the head and neck region when there is a suggestion of esophageal invasion on CT or MRI, or enlarged mediastinal lymph nodes. (elsevierpure.com)
  • Benign tumors can arise from soft tissue in the neck including fat, salivary tissue, lymph nodes, blood vessels, and nerves. (mhmedical.com)
  • The head and neck region, particularly tongue, is a common location for GLI1-related mesenchymal tumors. (johnshopkins.edu)
  • Despite the complex anatomy associated with base of tongue tumors, as well as concerns regarding posttreatment functional deficits, significant changes in management options for such neoplasms have vastly improved outcomes in recent years. (medscape.com)
  • His current interests are head-and-neck and prostate cancer, CNS neoplasms and neuroendocrine tumors. (philips.com)
  • In the majority of reported cases, triton tumors are located across peripheral nerves, usually close to the spine, in the head and neck region, or in the upper and lower extremities [ 16 ]. (hindawi.com)
  • The study involved 17 patients, including 11 with malignant tumors and six with benign neoplasms. (medscape.com)
  • CT-guided needle biopsy can be used to evaluate difficult-to-reach tumors, such as neoplasms in the parapharyngeal space. (medscape.com)
  • Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
  • Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck. (duke.edu)
  • Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. (duke.edu)
  • A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer. (nih.gov)
  • Proton Therapy for Head and Neck Cancer. (nih.gov)
  • Pain is one of the first presenting symptoms in patients with head and neck cancer, who often develop chronic and debilitating pain as the disease progresses. (nih.gov)
  • Unfortunately, patients rarely receive effective pain treatment due to our limited knowledge of the mechanisms underlying head and neck cancer pain (HNCP). (nih.gov)
  • These findings challenge the common belief that pain results from tissue compression or IL-1 signaling in patients with head and neck cancer. (nih.gov)
  • The purpose of this study is to elucidate the association between PM 2.5 and oral neoplasm, including oral potentially malignant disorder (OPMD) and oral cancer (OC), taking into account the geographical heterogeneity. (aaqr.org)
  • This textbook presents a succinct yet comprehensive overview of the current essential topics in the multidisciplinary care of head and neck cancer patients. (novapublishers.com)
  • Finally, this textbook's outline format, clear and concise language, and rich set of practice guidelines make it a trusted resource for nonmedical professionals hoping to learn more about head and neck cancer patients and their treatments. (novapublishers.com)
  • OBJECTIVES: I. Assess the efficacy and role of amifostine as a cytoprotection agent with concurrent chemoradiotherapy in advanced, previously irradiated or metastatic head and neck cancer. (knowcancer.com)
  • A prospective study of quality of life in head and neck cancer patients. (lu.se)
  • I'm joined today by Dr. Ruben Mesa, the director of the UT Health San Antonio MD Anderson Cancer Center and world-renowned MPN (myeloproliferative neoplasm) expert, and a dear colleague. (curetoday.com)
  • RÉSUMÉ Des études en milieu hospitalier ont révélé des fréquences relatives très élevées du cancer oropharyngé au Yémen. (who.int)
  • La présente étude a estimé les fréquences relatives du cancer de la cavité buccale et du pharynx chez des patients yéménites atteints de cancers enregistrés en 2007 et 2008. (who.int)
  • Median survival in head and neck (HNC) patients was 94 months, while median survival in oesophageal cancer patients was 10 months. (bath.ac.uk)
  • Head and neck cancer patients are a group with complex needs barely studied in the post-treatment phase. (bvsalud.org)
  • To understand the experience and needs of the head and neck cancer survival phase from the perspective of the patients themselves, their families, and health professionals from oncology services. (bvsalud.org)
  • Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck. (duke.edu)
  • Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. (duke.edu)
  • Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. (duke.edu)
  • Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck. (duke.edu)
  • The purpose of this study is to determine the efficacy and safety of pembrolizumab given concomitantly with chemoradiation (CRT) and as maintenance therapy versus placebo plus CRT in participants with locally advanced head and neck squamous cell carcinoma (LA HNSCC). (msdoncologyclinicaltrials.com)
  • Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study. (nih.gov)
  • A sagittal computed tomography (CT) scan of the neck with contrast demonstrates a pedunculated soft tissue lesion at the left base of the tongue without invasion of the floor of the mouth or adjacent structures. (medscape.com)
  • High-resolution computed tomography (CT) scanning of the neck with intravenous (IV) contrast is the most commonly utilized modality and has the advantages of increased availability and speed, with excellent spatial resolution, demonstration of bone infiltration, and lymph node visualization. (medscape.com)
  • Formatted like the bestselling 'Pasha' ( Otolaryngology-Head and Neck Surgery ) pocket guide, this text provides a condensed amount of high-yield information with a multidisciplinary approach to bring a broader range of insight into complex clinical challenges. (pluralpublishing.com)
  • Modeled after Dr. Raza Pasha's popular Otolaryngology Head and Neck Surgery Clinical Reference Guide, this portable reference book fills a niche in the reference world left empty too long. (pluralpublishing.com)
  • Nasopharyngeal laryngoscopy, fine-needle aspiration cytology, excision lymph-node biopsy (in Hodgkin lymphoma [HL] and non-Hodgkin lymphoma [NHL]), and bone marrow aspiration and biopsy are essential in the workup of patients with head and neck lymphomas. (medscape.com)
  • One important element in the diagnostic workup of the neck neoplasm is ruling out a malignant process. (mhmedical.com)
  • The imaging modality that is selected in the workup of a neck mass differs based on the differential diagnosis. (mhmedical.com)
  • Lymphoma is the second most common primary malignancy occurring in the head and neck. (medscape.com)
  • Examination of the skin including the scalp and posterior neck may reveal a source of a metastatic unknown primary tumor from a cutaneous malignancy. (mhmedical.com)
  • With each chapter written by experts in the many fields that comprise head and neck oncology and surgery, this compendium provides a unique, multidisciplinary perspective on the diagnosis and management of these patients. (novapublishers.com)
  • A 23-year-old female patient presented to the craniomaxillofacial and plastic surgery department at our institution with a 10-month left neck swelling. (hindawi.com)
  • A quarter of all extranodal lymphomas occur in the head and neck, and 8% of findings on supraclavicular fine-needle aspirate biopsy yield a diagnosis of lymphoma. (medscape.com)
  • A systematic approach is central in evaluation of neck masses including a detailed history and physical as well as a diagnostic evaluation to include imaging and tissue biopsy when appropriate. (mhmedical.com)
  • An incisional biopsy revealed the diagnosis of sporadic-type MTT (de novo) of the neck. (hindawi.com)
  • Sebaceous carcinoma is an outright malignant neoplasm with prominent cellular pleomorphism and anaplasia. (medscape.com)
  • Nasopharyngeal carcinoma (NPC) is a rare head and neck neoplasm worldwide. (intechopen.com)
  • Management of thyroid neoplasms. (medlineplus.gov)
  • The thyroid gland is a butterfly-shaped gland located inside the front of the lower neck. (stlukes-stl.com)
  • The thyroid gland is located at the front of the neck, just above where your collarbones m. (stlukes-stl.com)
  • The thyroid is a gland located in the neck. (stlukes-stl.com)
  • The abnormal growth of cells like primary or metastatic masses in the head and neck, thyroid and parathyroid lesions, or the traumatic injuries of the head and neck represents malignant neoplasm. (benthamscience.com)
  • Physical exam, imaging, and tissue diagnosis are used to differentiate benign from malignant neck masses. (mhmedical.com)
  • These neoplasms are mainly treated surgically and an accurate histological examination is mandatory for a precise diagnosis. (springer.com)
  • Rhabdomyoblastic differentiation in a malignant peripheral nerve sheath tumor (MPNST) is termed malignant triton tumor (MTT), a rare neoplasm that poses a diagnostic dilemma in the differential diagnosis of neck masses and portends poor prognosis. (hindawi.com)
  • eliminate a diagnosis of mycobacteriosis or neoplasm. (cdc.gov)
  • [ 2 , 3 ] It is estimated that overall, oropharyngeal SCCs will make up about 47% of all head and neck cancers in the United States by 2030. (medscape.com)
  • A cohort study in the Netherlands of 2510 exposed and 2199 unexposed persons did not document a statistically significant increase in head and neck cancers in the exposed group (2). (cdc.gov)
  • One group of those are the myeloproliferative neoplasms, which includes essential thrombocythemia, a disease named for having too many platelets, polycythemia vera, a disease named for having too many red blood cells, and myelofibrosis. (curetoday.com)
  • For vascular lesions, auscultation of the neck mass may reveal a bruit. (mhmedical.com)
  • Neck masses are common and can represent a wide range of benign and malignant lesions. (mhmedical.com)
  • We herein expand these findings by investigating a cohort of 11 head and neck lesions with GLI1 alterations, including 8 from the tongue, for their clinicopathologic and molecular features. (johnshopkins.edu)
  • Based on the investigation or attribution of the cause in children, lesions of the head and neck can be divided into different categories. (benthamscience.com)
  • This chapter discusses the common congenital head and neck malformations as well as inflammatory lesions. (benthamscience.com)
  • An axial CT scan of the neck with contrast again demonstrates a soft tissue left base of tongue lesion with slight extension into the glossotonsillar sulcus. (medscape.com)
  • Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue neoplasm with a poor prognosis. (hindawi.com)
  • Many cutaneous neoplasms occur in the setting of systemic syndromes. (wikipedia.org)
  • It recurred on the neck area 4 months after excision and the lesion was removed with surgical resection again. (nih.gov)
  • This approach allowed adequate resection of the neoplasm with minimal damage to the adjacent tissues, thus reducing post-surgical scarring. (springer.com)
  • EUS with FNA may avoid the need for mediastinoscopy or other more invasive techniques for staging of these neoplasms. (elsevierpure.com)
  • Elective neck dissection determines the presence of occult metastases for pathologic staging. (mhmedical.com)
  • Separately evaluate disabling effects other than disfigurement that are associated with individual scar(s) of the head, face, or neck, such as pain, instability, and residuals of associated muscle or nerve injury, under the appropriate diagnostic code(s) and apply § 4.25 to combine the evaluation(s) with the evaluation assigned under this diagnostic code. (cornell.edu)
  • The following conditions each represent 1 percent or more of diagnostic radiology claims: subarachnoid hemorrhage, malignant neoplasm of colon, malignant neoplasm of pancreas, cerebral thrombosis with infarction, acute cerebrovascular accident (CVA), cerebral aneurysm, pelvis fracture, ankle fracture, and intracranial abscess. (thedoctors.com)
  • See also 10 Patients with Neck Masses: Identifying Malignant versus Benign , a Critical Images slideshow, to help identify several types of masses. (medscape.com)
  • Patency of the airway can be compromised in patients with neck neoplasms and should be evaluated at the time of fiberoptic laryngoscopy. (mhmedical.com)
  • Causes of lym- was to define the frequency of B . henselae and other bac- phadenopathy other than neoplasm that require urgent terial infections in patients with suspected CSD in France. (cdc.gov)
  • A complete head and neck examination should be performed when evaluating a neck mass. (mhmedical.com)
  • A painful neck mass may suggest a neurogenic tumor such as schwannoma or neuroma. (mhmedical.com)