Haloperidol. Medical search

A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.

A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.

A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.

A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.

Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.

A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.

A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.

A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.

A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)

One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)

A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.

A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.

A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.

A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.

Drugs that bind to and activate dopamine receptors.

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)

Organized services to provide immediate psychiatric care to patients with acute psychological disturbances.

Relatively invariant mode of behavior elicited or determined by a particular situation; may be verbal, postural, or expressive.

A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.

An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.

An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)

A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.

The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)

A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A selective and potent serotonin-2 antagonist that is effective in the treatment of a variety of syndromes related to anxiety and depression. The drug also improves the subjective quality of sleep and decreases portal pressure.

Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.

An antipsychotic agent that is specific for dopamine D2 receptors. It has been shown to be effective in the treatment of schizophrenia.

Compounds containing phenyl-1-butanone.

A benzocycloheptapyridoisoquinolinol that has been used as an antipsychotic, especially in schizophrenia.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

A complex involuntary response to an unexpected strong stimulus usually auditory in nature.

Drugs used in the treatment of movement disorders. Most of these act centrally on dopaminergic or cholinergic systems. Among the most important clinically are those used for the treatment of Parkinson disease (ANTIPARKINSON AGENTS) and those for the tardive dyskinesias.

The physical activity of a human or an animal as a behavioral phenomenon.

A dopamine D2/D3 receptor agonist.

Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.

Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.

A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions.

Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.

A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.

An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.

A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.

The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.

A deaminated metabolite of LEVODOPA.

The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.

S-16924 [(R)-2-[1-[2-(2,3-dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]- pyrrolidin-3yl]-1-(4-fluorophenyl)-ethanone], a novel, potential antipsychotic with marked serotonin1A agonist properties: III. Anxiolytic actions in comparison with clozapine and haloperidol. (1/1058)

S-16924 is a potential antipsychotic that displays agonist and antagonist properties at serotonin (5-HT)1A and 5-HT2A/2C receptors, respectively. In a pigeon conflict procedure, the benzodiazepine clorazepate (CLZ) increased punished responses, an action mimicked by S-16924, whereas the atypical antipsychotic clozapine and the neuroleptic haloperidol were inactive. Similarly, in a Vogel conflict paradigm in rats, CLZ increased punished responses, an action shared by S-16924 but not by clozapine or haloperidol. This action of S-16924 was abolished by the 5-HT1A antagonist WAY-100,635. Ultrasonic vocalizations in rats were inhibited by CLZ, S-16924, clozapine, and haloperidol. However, although WAY-100,635 abolished the action of S-16924, it did not affect clozapine and haloperidol. In a rat elevated plus-maze, CLZ, but not S-16924, clozapine, and haloperidol, increased open-arm entries. Like CLZ, S-16924 increased social interaction in rats, whereas clozapine and haloperidol were inactive. WAY-100,635 abolished this action of S-16924. CLZ, S-16924, clozapine, and haloperidol decreased aggressive interactions in isolated mice, but this effect of S-16924 was not blocked by WAY-100, 635. All drugs inhibited motor behavior, but the separation to anxiolytic doses was more pronounced for S-16924 than for CLZ. Finally, in freely moving rats, CLZ and S-16924, but not clozapine and haloperidol, decreased dialysis levels of 5-HT in the nucleus accumbens: this action of S-16924 was blocked by WAY-100,165. In conclusion, in contrast to haloperidol and clozapine, S-16924 possessed a broad-based profile of anxiolytic activity at doses lower than those provoking motor disruption. Its principal mechanism of action was activation of 5-HT1A (auto)receptors. (+info)

Ergoline derivative LEK-8829-induced turning behavior in rats with unilateral striatal ibotenic acid lesions: interaction with bromocriptine. (2/1058)

LEK-8829 [9,10-didehydro-N-methyl-(2-propynyl)-6-methyl-8- aminomethylergoline bimaleinate] is an antagonist of dopamine D2 receptors and serotonin (5-HT)2 and 5-HT1A receptors in intact animals and a D1 receptor agonist in dopamine-depleted animals. In the present study, we used rats with unilateral striatal lesions with ibotenic acid (IA) to investigate the dopamine receptor activities of LEK-8829 in a model with innervated dopamine receptors. The IA-lesioned rats circled ipsilaterally when challenged with apomorphine, the mixed agonist on D1/D2 receptors. LEK-8829 induced a dose-dependent contralateral turning that was blocked by D1 receptor antagonist SCH-23390. The treatment with D1 receptor agonist SKF-82958 induced ipsilateral turning, whereas the treatment with D2 receptor antagonist haloperidol induced contralateral posture. The combined treatment with SKF-82958 and haloperidol resulted in a weak contralateral turning, indicating the possible receptor mechanism of contralateral turning induced by LEK-8829. Bromocriptine induced a weak ipsilateral turning that was blocked by haloperidol. The ipsilateral turning induced by bromocriptine was significantly potentiated by the coadministration of a low dose but not by a high dose of LEK-8829. The potentiation of turning was blocked either by SCH-23390 or by haloperidol. The potentiation of ipsilateral turning suggests the costimulation of D2 and D1 receptors by bromocriptine and LEK-8829, respectively, whereas the lack of potentiation by the highest dose of LEK-8829 may be explained by the opposing activity of LEK-8829 and bromocriptine at D2 receptors. We propose that the D2 and 5HT2 receptor-blocking and D1 receptor-stimulating profile of LEK-8829 is promising for the treatment of negative symptoms of schizophrenia. (+info)

Behavioral, toxic, and neurochemical effects of sydnocarb, a novel psychomotor stimulant: comparisons with methamphetamine. (3/1058)

Sydnocarb (3-(beta-phenylisopropyl)-N-phenylcarbamoylsydnonimine) is a psychostimulant in clinical practice in Russia as a primary and adjunct therapy for a host of psychiatric disorders, including schizophrenia and depression. It has been described as a stimulant with an addiction liability and toxicity less than that of amphetamines. The present study undertook to evaluate the psychomotor stimulant effects of sydnocarb in comparison to those of methamphetamine. Sydnocarb increased locomotor activity of mice with reduced potency (approximately 10-fold) and efficacy compared with methamphetamine. Sydnocarb blocked the locomotor depressant effects of haloperidol at doses that were inactive when given alone. The locomotor stimulant effects of both methamphetamine and sydnocarb were dose-dependently blocked by the dopamine D1 and D2 antagonists SCH 39166 and spiperone, respectively; blockade generally occurred at doses of the antagonists that did not depress locomotor activity when given alone. In mice trained to discriminate methamphetamine from saline, sydnocarb fully substituted for methamphetamine with a 9-fold lower potency. When substituted for methamphetamine under self-administration experiments in rats, 10-fold higher concentrations of sydnocarb maintained responding by its i.v. presentation. Sydnocarb engendered stereotypy in high doses with approximately a 2-fold lower potency than methamphetamine. However, sydnocarb was much less efficacious than methamphetamine in inducing stereotyped behavior. Both sydnocarb and methamphetamine increased dialysate levels of dopamine in mouse striatum; however, the potency and efficacy of sydnocarb was less than methamphetamine. The convulsive effects of cocaine were significantly enhanced by the coadministration of nontoxic doses of methamphetamine but not of sydnocarb. Taken together, the present findings indicate that sydnocarb has psychomotor stimulant effects that are shared by methamphetamine while demonstrating a reduced behavioral toxicity. (+info)

Effect of psychotropic drugs on caudate spindle in cats. (4/1058)

To ascertain whether neuroleptics act on the caudate nucleus itself, the effects of these compounds as well as other centrally acting drugs were examined in relation to caudate spindle and EEG arousal responses (sciatic nerve stimulation) in gallamine-immobilized cats. Haloperidol and chlorpromazine enhanced the caudate spindle at a dose which had no effect on the EEG arousal response. On the other hand, clozapine and a higher dose of chlorpromazine enhanced the caudate spindle, but depressed the arousal response. High frequency stimulation of the sciatic nerve suppressed the caudate spindle. Pentobarbital, biperiden and diazepam, while depressing the arousal response, caused an enhancement of the caudate spindle. Imipramine at a low dose had no effect on either response, whereas at a high dose this drug enhanced the caudate spindle with concomitant depression of the arousal response. From these results, it may be concluded that the enhancing action on the caudate spindle induced by haloperidol and a low dose of chlorpromazine is due to an increase in susceptibility of the caudate nucleus itself. In addition, it is suggested that depression of the activating system is involved in an appearance of the caudate spindle. (+info)

Comparison of effects of haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. (5/1058)

Research has shown that there are important neurochemical differences between the mesocortical and mesostriatal dopamine systems. The work reported in this paper has sought to compare the regulation of dopamine release in the medial prefrontal cortex and the anterior caudate-putamen. In vivo microdialysis was used to recover dialysate fluid for subsequent assay for dopamine concentrations. The responses to D2 antagonist (haloperidol) administration, which has been shown to increase impulse-dependent dopamine release, were compared. Results demonstrated a diminished effect of systemic haloperidol administration on dopamine efflux in the prefrontal cortex. The responses to systemic administration of a nonimpulse-dependent, transporter-mediated, dopamine releaser (d-amphetamine) were also contrasted. Results again demonstrated a diminished pharmacological effect in the cortex. The potential interaction of stimulation of these two types of dopamine release was examined by coadministration of these compounds. Haloperidol pretreatment dramatically potentiated the dopamine-releasing effect of amphetamine administration. This effect was observed in both the cortex and the striatum. Subsequent work demonstrated that this effect of haloperidol was mediated by D2-like receptors in the prefrontal cortex. These results are discussed in relation to other neurochemical and neuroanatomical studies demonstrating sparse densities of dopamine transporter sites and dopamine D2 receptors in the cortex compared with the striatum. They demonstrate a functional correlate to the recently reported, largely extrasynaptic localization of dopamine transporter sites in the prefrontal cortex. Furthermore, they demonstrate the existence of cortical D2-like autoreceptors that may normally be "silent" under basal conditions. (+info)

Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line. (6/1058)

The sigma binding site present in the Jurkat human T lymphocyte cell line was investigated. Jurkat cell membranes were found to have a single saturable binding site for [3H]haloperidol, a sigma ligand (dissociation constant, 3.9 +/- 0.3 nM). The binding of [3H]haloperidol was inhibited by several sigma ligands. Northern analysis and reverse transcription-polymerase chain reaction provided evidence for the expression of the recently cloned type 1 sigma-receptor (sigma-R1) in Jurkat cells. The sigma-R1 cDNA cloned from these cells was functional in heterologous expression systems. When expressed in mammalian cells, the cDNA-induced binding was saturable with dissociation constants of 1.9 +/- 0.3 nM for [3H]haloperidol and 12 +/- 2 nM for (+)-pentazocine. The binding of [3H]progesterone, a putative endogenous ligand to sigma-R1, to the Jurkat cell sigma-receptor could be directly demonstrated by using heterologously expressed sigma-R1 cDNA. The binding of [3H]progesterone was saturable, with a dissociation constant of 88 +/- 7 nM. Progesterone and haloperidol interacted with the receptor competitively. Reverse transcription-polymerase chain reaction also produced evidence for the existence of an alternatively spliced sigma-R1 variant in Jurkat cells. This splice variant was found to be nonfunctional in ligand binding assays. This constitutes the first report on the molecular characterization of the sigma-receptor in immune cells. (+info)

Synergistic interactions between ampakines and antipsychotic drugs. (7/1058)

Tests were made for interactions between antipsychotic drugs and compounds that enhance synaptic currents mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-type glutamate receptors ("ampakines"). Typical and atypical antipsychotic drugs decreased methamphetamine-induced hyperactivity in rats; the effects of near or even subthreshold doses of the antipsychotics were greatly enhanced by the ampakines. Interactions between the ampakine CX516 and low doses of different antipsychotics were generally additive and often synergistic. The ampakine did not exacerbate neuroleptic-induced catalepsy, indicating that the interaction between the different pharmacological classes was selective. These results suggest that positive modulators of cortical glutamatergic systems may be useful adjuncts in treating schizophrenia. (+info)

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site. (8/1058)

P-glycoprotein is a plasma membrane protein of mammalian cells that confers multidrug resistance by acting as a broad-specificity, ATP-dependent efflux transporter of diverse lipophilic neutral or cationic compounds. Previously, we identified two positively cooperative drug-binding sites of P-glycoprotein involved in transport [Shapiro, A. B. & Ling, V. (1997) Eur. J. Biochem. 250, 130-137]. The H site is selective for Hoechst 33342 and colchicine. The R site is selective for rhodamine 123 and anthracyclines. Substrate binding to one site stimulates transport by the other. In this paper, we show that prazosin and progesterone stimulate the transport of both Hoechst 33342 and rhodamine 123. Rhodamine 123 and prazosin (or progesterone) in combination stimulate Hoechst 33342 transport in an additive manner. In contrast, Hoechst 33342 and either prazosin or progesterone interfere with each other, so that the stimulatory effect of the combination on rhodamine 123 transport is less than that of each individually. Non-P-glycoprotein-specific effects of prazosin on membrane fluidity and permeability were excluded. These results indicate the existence of a third drug-binding site on P-glycoprotein with a positive allosteric effect on drug transport by the H and R sites. This allosteric site appears to be one of the sites of photoaffinity labeling of P-glycoprotein by [125I]iodoarylazidoprazosin [Safa, A. R., Agresti, M., Bryk, D. & Tamai, I. (1994) Biochemistry 33, 256-265] and is likely not to be capable of drug transport. (+info)

... is excreted in breast milk. A few studies have examined the impact of haloperidol exposure on breastfed infants and ... Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the ... A 2013 systematic review compared haloperidol to placebo in schizophrenia: Data from animal experiments indicate haloperidol is ... The decanoate ester of haloperidol (haloperidol decanoate, trade names Haldol decanoate, Halomonth, Neoperidole) has a much ...

https://en.wikipedia.org/wiki/Haloperidol

... is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or ... Haloperidol decanoate, sold under the brand name Haldol Decanoate among others, is a typical antipsychotic which is used in the ... "Haloperidol Uses, Side Effects & Warnings". Parent M, Toussaint C, Gilson H (1983). "Long-term treatment of chronic psychotics ... Reyntigens AJ, Heykants JJ, Woestenborghs RJ, Gelders YG, Aerts TJ (1982). "Pharmacokinetics of haloperidol decanoate. A 2-year ...

https://en.wikipedia.org/wiki/Haloperidol_decanoate

Haloperidol • Loxapine • Mesoridazine • Methotrimeprazine • Nemonapride • Penfluridol • Perazine • Periciazine • Perphenazine ...

https://en.wikipedia.org/wiki/List_of_dopaminergic_drugs

Atypicals are less likely than haloperidol - the most widely used typical antipsychotic - to cause extrapyramidal motor control ... Reyntigens AJ, Heykants JJ, Woestenborghs RJ, Gelders YG, Aerts TJ (1982). "Pharmacokinetics of haloperidol decanoate. A 2-year ... Beresford R, Ward A (January 1987). "Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic ... PAFIP 3-Year Follow-Up Randomized Clinical Trials Comparing Haloperidol, Olanzapine, Risperidone, Aripiprazole, Quetiapine, and ...

https://en.wikipedia.org/wiki/Atypical_antipsychotic

https://en.wikipedia.org/wiki/Paliperidone_palmitate

HALOPERIDOL 67. HALOTAN 68. CLORAL HYDRATE 69. HYDROCHLORBEZETILAMINE 70. HYDROXIDINE 71. HOMOPHENAZINE 72. IMICLOPRAZINE 73. ...

https://en.wikipedia.org/wiki/Brazilian_Controlled_Drugs_and_Substances_Act

https://en.wikipedia.org/wiki/Perphenazine

... were the typical antipsychotics fluphenazine and haloperidol. Both fluphenazile and haloperidol are formulated as decanoates, ... Haloperidol, due to the availability of a rapid-acting injectable formulation and decades of use, remains the most commonly ... For reference, the typical antipsychotic haloperidol tends to block about 80% of D2 receptors at doses ranging from 2 to 5 mg ... Another prominent grouping of antipsychotics are the butyrophenones, an example of which is haloperidol. The newer, second- ...

https://en.wikipedia.org/wiki/Typical_antipsychotic

https://en.wikipedia.org/wiki/Fluspirilene

Reyntigens AJ, Heykants JJ, Woestenborghs RJ, Gelders YG, Aerts TJ (1982). "Pharmacokinetics of haloperidol decanoate. A 2-year ... Beresford R, Ward A (January 1987). "Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic ... haloperidol and placebo in recently-hospitalized acute schizophrenic patients". Brazilian Journal of Medical and Biological ...

https://en.wikipedia.org/wiki/Pipotiazine

https://en.wikipedia.org/wiki/Clopenthixol

https://en.wikipedia.org/wiki/Paliperidone

https://en.wikipedia.org/wiki/Fluphenazine

Reyntigens AJ, Heykants JJ, Woestenborghs RJ, Gelders YG, Aerts TJ (1982). "Pharmacokinetics of haloperidol decanoate. A 2-year ... Beresford R, Ward A (January 1987). "Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic ... antipsychotics like haloperidol and second-generation (atypical) antipsychotics like clozapine. It has received this ... approximately as effective as haloperidol and quetiapine and slightly more effective than ziprasidone, chlorpromazine, and ...

https://en.wikipedia.org/wiki/Aripiprazole

Reyntigens AJ, Heykants JJ, Woestenborghs RJ, Gelders YG, Aerts TJ (1982). "Pharmacokinetics of haloperidol decanoate. A 2-year ... Beresford R, Ward A (January 1987). "Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic ... Bromperidol decanoate Clopentixol decanoate Flupentixol decanoate Fluphenazine decanoate Fluphenazine enanthate Haloperidol ...

https://en.wikipedia.org/wiki/Antipsychotic_ester

https://en.wikipedia.org/wiki/Viscoleo

https://en.wikipedia.org/wiki/Oxyprothepin_decanoate

https://en.wikipedia.org/wiki/Perphenazine_enanthate

https://en.wikipedia.org/wiki/Bromperidol

https://en.wikipedia.org/wiki/Aripiprazole_lauroxil

https://en.wikipedia.org/wiki/Bromperidol_decanoate

Reyntigens AJ, Heykants JJ, Woestenborghs RJ, Gelders YG, Aerts TJ (1982). "Pharmacokinetics of haloperidol decanoate. A 2-year ... Beresford R, Ward A (January 1987). "Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic ... that evidence is strong that risperidone is more effective than all first-generation antipsychotics other than haloperidol, but ...

https://en.wikipedia.org/wiki/Risperidone

"Poisonous KO?" Author: D. Lederman "Haloperidol". The American Society of Health-System Pharmacists. Archived from the original ... but Katlin suggested that Klitschko could have been poisoned with Haloperidol. The drug has no taste or smell and causes mental ...

https://en.wikipedia.org/wiki/Wladimir_Klitschko

Haloperidol - a typical antipsychotic. Risperidone - (Risperdal, and generics) is a second-generation or atypical antipsychotic ...

https://en.wikipedia.org/wiki/Outline_of_autism

Vella-Brincat J, Macleod AD (April 2004). "Haloperidol in palliative care". Palliative Medicine. 18 (3): 195-201. doi:10.1191/ ... Nausea and vomiting Typically controlled using haloperidol, metoclopramide, ondansetron, cyclizine; or other anti-emetics. ... antipsychotics such as haloperidol or levomepromazine may also be used instead of, or concomitantly with benzodiazepines. ...

https://en.wikipedia.org/wiki/End-of-life_care

Enciprazine BMY-14802 Azaperone Janssen PA (1967). "Haloperidol and related butyrophenones". In Gordon M (ed.). ...

https://en.wikipedia.org/wiki/Fluanisone

Haloperidol, Chlorpromazine Serotonin syndrome; excessive serotonergic activity due usually to combined use of serotonergic ...

https://en.wikipedia.org/wiki/Drug-induced_hyperthermia

https://en.wikipedia.org/wiki/Wladimir_Klitschko_vs._Lamon_Brewster

... haloperidol, benperidol, etc.); metoclopramide and Tetrabenazine. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a drug ...

https://en.wikipedia.org/wiki/Parkinson's_disease

Haldol (haloperidol) - typical antipsychotic. Imovane (zopiclone) - a non-benzodiazepine hypnotic. Inderal (propranolol) - a ...

https://en.wikipedia.org/wiki/List_of_psychotropic_medications

Haloperidol: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Haloperidol may help control your condition, but will not cure it. Continue to take haloperidol even if you feel well. Do not ... Before taking haloperidol,. *tell your doctor and pharmacist if you are allergic to haloperidol or any other medications. ... Alcohol can make the side effects of haloperidol worse.. *you should know that haloperidol may cause dizziness, lightheadedness ...

https://medlineplus.gov/druginfo/meds/a682180.html

Haloperidol is supplied as tablets for oral administration containing 0.5 mg, 1 mg, 2 mg, 5 mg, 10 mg or 20 mg of haloperidol, ... Haloperidol Tablets, USP are available containing 0.5 mg, 1 mg, 2 mg, 5 mg, 10 mg or 20 mg of haloperidol, USP. ... In a study of 12 schizophrenic patients coadministered haloperidol and rifampin, plasma haloperidol levels were decreased by a ... The possibility that haloperidol caused death cannot, of course, be excluded, but it is to be kept in mind that sudden and ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2c26af24-5ed3-4eb7-8d29-d6a019320a70

... treatment with haloperidol did not lead to a significantly greater number of days alive and out of the hospital at 90 days than ... Haloperidol for the Treatment of Delirium in ICU Patients N Engl J Med. 2022 Oct 26. doi: 10.1056/NEJMoa2211868. Online ahead ... Background: Haloperidol is frequently used to treat delirium in patients in the intensive care unit (ICU), but evidence of its ... Haloperidol or placebo was administered in the ICU for as long as delirium continued and as needed for recurrences. The primary ...

https://pubmed.ncbi.nlm.nih.gov/36286254/

TEVA HALOPERIDOL, 1MG, TABLET. Common uses. This medication is typically used for agitation and aggressiveness or for certain ...

https://www.uniprix.com/en/drug-lexicon/00363677/Teva-Haloperidol

... half doses of haloperidol outperformed ondansetron, an old standby ... Vomiting/Nausea in the ED? Consider Haloperidol, Study Suggests. - In randomized trial, half doses of haloperidol outperformed ... Haloperidol] is definitely a drug thats going to help young patients with benign abdomens who come in with vomiting and ... SAN FRANCISCO - Haloperidol may be a better option than the old standby ondansetron to treat certain patients with vomiting and ...

https://www.medpagetoday.com/meetingcoverage/acep/101075?trw=yes&hr=kmd

Haloperidol is not approved for use in older adults with dementia-related psychosis.What is haloperidol?Haloperidol is an ... Haldol DecanoateWhat is the most important information I should know about haloperidol? ... What is the most important information I should know about haloperidol?. Haloperidol is not approved for use in older adults ... How is haloperidol injection given?. You may be given oral haloperidol to take by mouth for a short time before you are treated ...

https://www.uofmhealth.org/health-library/d00027v1

Chronic exposure to haloperidol and olanzapine leads to common and divergent shape changes in the rat hippocampus in the ... Mondelli, V, Anacker, C, Vernon, AC, Cattaneo, A, Natesan, S, Modo, M, Dazzan, P, Kapur, S, Pariante, CM (2013). Haloperidol ... Vernon, AC, Natesan, S, Crum, WR, Cooper, JD, Modo, M, Williams, SC, Kapur, S (2012). Contrasting effects of haloperidol and ... Reinke, A, Martins, MR, Lima, MS, Moreira, JC, Dal-Pizzol, F, Quevedo, J (2004). Haloperidol and clozapine, but not olanzapine ...

https://www.cambridge.org/core/journals/psychological-medicine/article/chronic-exposure-to-haloperidol-and-olanzapine-leads-to-common-and-divergent-shape-changes-in-the-rat-hippocampus-in-the-absence-of-greymatter-volume-loss/5A53FB4C7951EC2EC5F402353F580851

Acute administration of haloperidol (1 mg/kg, i.v.) did not modify the neuronal responsiveness to DA and KA but increased that ... Since long-term haloperidol treatment results in a depolarization inactivation of A10 dopaminergic neurons, these results ... Long-term treatment with haloperidol decanoate (4 mg/kg/week, i.m., for 3-5 weeks) induced a marked increase in the ... The present experiments were undertaken to determine the effect of acute and long-term administration of haloperidol on the ...

https://www.jneurosci.org/content/10/2/469

Reversal of haloperidol-induced catalepsy in Sprague-Dawley rat at 10 mg/kg, sc after 120 mins relative to control. ...

https://pubchem.ncbi.nlm.nih.gov/bioassay/1259971

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.. V I Ilyin, E R Whittemore, J Guastella, E Weber ... Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.. V I Ilyin, E R Whittemore, J Guastella, E Weber ... Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.. V I Ilyin, E R Whittemore, J Guastella, E Weber ... Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol. Message Subject (Your Name) has forwarded a page ...

https://molpharm.aspetjournals.org/content/50/6/1541/tab-e-letters

a) For the transport of wild African elephants, according to shoulder height: 1.60-1.69 m shoulder height (40 mg haloperidol); ... So the animal was put on 100 mg haloperidol twice daily orally. This relieved the symptoms very well but without sedation ... b) Following immobilization for translocation of 670 African elephants in family units in 1993, haloperidol (40 to 120 mg ... d) an adult Asian bull was given 100 mg haloperidol orally bid. Text below (Cheeran, et.al. 1992). ...

https://elephantcare.org/resources/formulary/drug-index/haloperidol/

To compare the utility of intramuscular lorazepam (LZ) with the combination of intramuscular haloperidol (HDL) and LZ to ... with the combination of intamuscular haloperidol (HDL) and LZ to control acutely agitated behavior is compared. Study Objective ... Haloperidol for sedation of disruptive emergency patients.. *J. Clinton, S. Sterner, Z. Stelmachers, E. Ruiz ... Droperidol versus haloperidol for chemical restraint of agitated and combative patients.. *H. Thomas, E. Schwartz, R. Petrilli ...

https://www.semanticscholar.org/paper/A-Double%E2%80%90Blind-Study-of-Lorazepam-versus-the-of-and-Bieniek-Ownby/d4774ad9b02cba976a97ccc0a2210b75309e2568

Haloperidol lactate (Bedford Laboratories) 7.5 mg and haloperidol decanoate (Sicor Pharmaceuticals, Irvine, CA, USA) 75 mg were ... The use of other ND in wildlife species is discussed elsewhere.1,3,4,6,11 The oral form of haloperidol (Haloperidol ... Due to persistent anxiety, inappetance and injurious behavior, 160 mg of IM haloperidol (Haloperidol USP, 20 mg/ml, Kyron ... such as haloperidol. Haloperidol and other typical ND act on the D2 subset of dopamine receptors.12 The D2 receptor is believed ...

https://www.vin.com/apputil/content/defaultadv1.aspx?id=9974569&pid=26428&

You need to be signed in to access email alerts. If you have an account log in with your user name and password. If you dont have an account you can just enter your email address in the email box below ...

https://ebmh.bmj.com/content/9/1/9.alerts

Examination of baseline risk factors for QTc interval prolongation in patients prescribed intravenous haloperidol. ... Following intravenous haloperidol administration, 46.9% of subjects had a follow-up ECG obtained within 24 hours. At the time ... BACKGROUND: Intravenous haloperidol can increase the risk for corrected QT interval (QTc) prolongation, torsades de pointes ( ... There are a number of risk factors reported in the literature for QTc prolongation and TdP with intravenous haloperidol. ...

https://scholars.duke.edu/display/pub772372

... treated with low dose olanzapine or haloperidol; A randomized double-blind study, Schizophrenia Research, vol. 53, no. 3, pp. ... treated with low dose olanzapine or haloperidol; A randomized double-blind study. / Haan, L.; van Bruggen, M.; Lavalaye, J. et ... treated with low dose olanzapine or haloperidol; A randomized double-blind study. Schizophrenia Research, 53(3), 179-180. ... treated with low dose olanzapine or haloperidol; A randomized double-blind study. In: Schizophrenia Research. 2002 ; Vol. 53, ...

https://research.vu.nl/en/publications/subjective-experience-and-d-2-receptor-occupancy-in-patients-with

antipsychotic-induced parkinsonism, elderly, haloperidol, pharmacogenetics, polymorphism Persistent URL doi.org/10.1097/JCP. ... Genetic variation and the risk of haloperidol-related parkinsonism in elderly patients: A candidate gene approach. Publication ... Genetic variation and the risk of haloperidol-related parkinsonism in elderly patients: A candidate gene approach. Journal of ... elderly patients.This cross-sectional study included 150 inpatients aged 65 years and older who were treated with haloperidol. ...

https://repub.eur.nl/pub/40253

A publicly available article also appearing in PubMed about Haloperidol ... Dosing of haloperidol is 0.05 to 0.075 mg/kg/day. *Geriatric considerations: Haloperidol is identified as a high-risk ... Haloperidol is a first-generation (typical) antipsychotic that is a commonly used drug worldwide. Haloperidol is used to manage ... Haloperidol lactate is available in a short-acting parenteral solution (5 mg/mL) injected intramuscularly. Haloperidol ...

https://www.statpearls.com/ArticleLibrary/viewarticle/22504

... to deliver haloperidol through the skin. The concentrations of the drug, haloperidol, the enhancer, farnesol and the gelator, ... SMGA gels for the skin permeation of haloperidol. Journal of Controlled Release 106 (1-2) : 88-98. [email protected] Repository. ... to investigate the influence of factor level changes on the permeability coefficient and permeation lag-time of haloperidol. ...

https://scholarbank.nus.edu.sg/handle/10635/53176?mode=full

Before using haloperidol, tell your doctor or pharmacist of all the drugs you take and if you have any of the following ... In rare cases, haloperidol may increase your level of a certain chemical made by the body (prolactin). For females, this ... Haloperidol can also be used to treat uncontrolled movements and outbursts of words/sounds related to Tourette\s syndrome. ... Before using haloperidol, report all medications you are currently using to your doctor or pharmacist. Tell your doctor or ...

https://www.healthwarehouse.com/-2704715.html

A randomised, double-blind, placebo-controlled trial to compare the early administration of intravenous haloperidol versus ... placebo-controlled trial to compare the early administration of intravenous haloperidol versus placebo in the prevention and ...

http://wrap.warwick.ac.uk/106022/

Transdermal nicotine and haloperidol in Tourettes disorder: a double-blind placebo-controlled study. J Clin Psychiatry. 2001 ... Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind, placebo-controlled study in ... The anti-tic efficacy of haloperidol has been known for 40 years. It blocks postsynaptic mesolimbic dopaminergic D1 and D2 ... Fluphenazine is a high-potency typical antipsychotic with pharmacology similar to that of haloperidol. It is proven to diminish ...

https://www.medscape.com/answers/1182258-177529/which-medications-in-the-drug-class-antipsychotic-agents-are-used-in-the-treatment-of-tourette-syndrome-and-other-tic-disorders

Haloperidol, a dopaminergic antagonist, was found to be very effective in suppressing the intraocular pressure recovery curve ... Haloperidol was at least equipotent, if not more potent, in lowering IOP and had much longer duration of action compared with ... Since haloperidol does not block β-adrenergic receptors and the ophthalmic dose required to lower IOP is only 6.5% of the ... Haloperidol, a dopaminergic antagonist, was found to be very effective in suppressing the intraocular pressure recovery curve ...

https://jamanetwork.com/journals/jamaophthalmology/article-abstract/634911

The concentrations of the admixtures were 0.15-0.25 mg/mL and 0.3-0.4 mg/mL of haloperidol and ondansetron, respectively, with ... The objective of this work is to study the stability of solutions of ondansetron and haloperidol at different concentrations ... Stability of mixtures of ondansetron and haloperidol stored in infusors at different temperatures ... Stability of mixtures of ondansetron and haloperidol stored in infusors at different temperatures ...

https://ejhp.bmj.com/content/25/e2/e134

Sato T, Takeichi M. Drug-induced pneumonitis associated with haloperidol. A case report. General Hospital Psychiatry. 1990 9月; ... Sato, T. ; Takeichi, M. / Drug-induced pneumonitis associated with haloperidol. A case report. In: General Hospital Psychiatry ... Sato, T & Takeichi, M 1990, Drug-induced pneumonitis associated with haloperidol. A case report, General Hospital Psychiatry ... Sato, T., & Takeichi, M. (1990). Drug-induced pneumonitis associated with haloperidol. A case report. General Hospital ...

https://kyushu-u.pure.elsevier.com/ja/publications/drug-induced-pneumonitis-associated-with-haloperidol-a-case-repor

Haloperidol is commonly used for the prevention and treatment of delirium in the ICU. Could it also provide survival benefits? ... Results were stable by prevention study-arm, predelirium haloperidol exposure, and haloperidol treatment protocol adherence. ... received treatment haloperidol (2.1 mg [1.0-3.8 mg] daily) for 6 days (3-11 d). Each milligram of treatment haloperidol ... Objectives: Haloperidol is commonly administered in the ICU to reduce the burden of delirium and its related symptoms despite ...

https://www.staging.medscape.com/viewarticle/955328

Bansal SK, Patial RK, Kumar V, Sharma R. Miosis with haloperidol. Journal of the Association of Physicians of India. 1992 Jan; ...

https://imsear.searo.who.int/handle/123456789/89860

Haloperidol decanoate is used for long-term treatment of a certain mental/mood disorder (schizophrenia). ... Most likely, you have used the form of haloperidol that is taken by mouth. Your doctor is using this form of haloperidol so ... Before using haloperidol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This ... Before using haloperidol decanoate, tell your doctor or pharmacist of all the drugs you take and if you have any of the ...

https://www.blinkhealth.com/haldol-decanoate

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Do you take haloperidol (Haldol)? (medscape.com)

Chronic exposure to haloperidol and olanzapine leads. (cambridge.org)
We examined the effect of chronic exposure (8 weeks) to clinically relevant doses of either haloperidol (HAL) or olanzapine (OLZ) on adult rat hippocampal volume and shape using ex vivo structural MRI with the brain retained inside the cranium to prevent distortions due to dissection, followed by tensor-based morphometry (TBM) and elastic surface-based shape deformation analysis. (cambridge.org)
Low doses of haloperidol combined with midazolam can be as effective as olanzapine in reducing psychomotor agitation without increasing the risk of extrapyramidal effects. (semanticscholar.org)
Olanzapine is an atypical antipsychotic that produces fewer acute parkinsonian, akathisic, or dystonic adverse effects than haloperidol. (medscape.com)
In the present study, we compared the effects of olanzapine, an atypical antipsychotic, with those of haloperidol, a typical neuroleptic, on the impairments of spatial memory and decreased ACh levels induced by THC (6 mg/kg, i.p.) in rats. (elsevier.com)
We found that olanzapine (0.1 mg/kg, i.p.) reversed the THC-induced memory deficits and decrease in extracellular ACh levels, whereas haloperidol (0.03-0.3 mg, i.p.) had no effect. (elsevier.com)
In several hospitals I was given haloperidol, olanzapine or lorazepam without my permission cause I was not able to speak for myself any more. (wordpress.com)
We have retrospectively analysed the EEG recordings of patients treated with the new antipsychotic quetiapine and compared it with those treated with olanzapine and haloperidol and a control group of 30 healthy subjects. (biomedcentral.com)
Patient groups were defined by medication as follows: quetiapine (n = 22), olanzapine (n = 37) or haloperidol (n = 22). (biomedcentral.com)
One patient from the quetiapine group (5%), 13 olanzapine patients (35%), five of the haloperidol patients (23%) and two subjects of the control group (7%) had an abnormal EEG. (biomedcentral.com)
EEG abnormalities seem to occur rarely in patients treated with quetiapine comparable to the control group, but significantly more often with haloperidol and olanzapine, possibly due to different receptor profiles of these substances. (biomedcentral.com)

Long-term treatment with haloperidol decanoate (4 mg/kg/week, i.m., for 3-5 weeks) induced a marked increase in the responsiveness to CCK-8S, without noticeable change of that to DA and KA. (jneurosci.org)
Haloperidol decanoate is available for long-acting intramuscular preparation. (statpearls.com)
Haloperidol decanoate is used for long-term treatment of a certain mental/mood disorder (schizophrenia). (blinkhealth.com)

Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as haloperidol have an increased chance of death during treatment. (medlineplus.gov)
Haloperidol is in a group of medications called conventional antipsychotics. (medlineplus.gov)
Haloperidol tablets, USP should be reserved for these two groups of children only after failure to respond to psychotherapy or medications other than antipsychotics. (nih.gov)
Haloperidol belongs to the class of medications called antipsychotics. (pocketpills.com)
They compared the numbers of suicide events in people that used first generation antipsychotics like haloperidol to people who used newer second generation antipsychotics like risperidone . (rxwiki.com)

Haloperidol is an antipsychotic medicine that is used to treat schizophrenia. (uofmhealth.org)
Haloperidol is used to manage positive symptoms of schizophrenia, such as hallucinations and delusions. (statpearls.com)
Haloperidol is used to treat certain mental/mood disorders (e.g., schizophrenia, schizoaffective disorders). (healthwarehouse.com)
In schizophrenia, it has approximately 33%-50% the risk of tardive dyskinesia compared with haloperidol. (medscape.com)
Haloperidol is used in the treatment of schizophrenia. (buy-pharma.md)
Haloperidol is used to manage acute and chronic psychosis and psychiatric disorders, including Schizophrenia and manic states. (pocketpills.com)
After individual determination of neuroleptic threshold (NT) doses of haloperidol, 106 patients with schizophrenia or schizoaffective disorder (Research Diagnostic Criteria) were treated openly at such doses (mean, 3.7± 2.3 mg/d) for 2 weeks. (elsevier.com)
McEvoy, JP , Hogarty, GE & Steingard, S 1991, ' Optimal Dose of Neuroleptic in Acute Schizophrenia: A Controlled Study of the Neuroleptic Threshold and Higher Haloperidol Dose ', Archives of General Psychiatry , vol. 48, no. 8, pp. 739-745. (elsevier.com)

Higher than recommended doses of any formulation of haloperidol appear to be associated with a higher risk of QT-prolongation and Torsades de pointes. (nih.gov)
High doses or long-term use of haloperidol can cause a serious movement disorder that may not be reversible. (uofmhealth.org)
For adults with psychosis or Tourette's syndrome, the usual starting dose of oral (taken by mouth) haloperidol ranges from 2 mg to 6 mg per day in 1 to 2 divided doses. (pocketpills.com)
All 10 patients received supportive psychotherapy and haloperidol in low doses (2.5−5 mg daily). (cdc.gov)
iTEK PHARMA propose un concept clé en main pharmaflash pour votre pharmacie en ligne sur le web : une solution complète avec du webmarketing.4014 lamictal xr doses . (elcolectivo506.com)

In this multicenter, blinded, placebo-controlled trial, we randomly assigned adult patients with delirium who had been admitted to the ICU for an acute condition to receive intravenous haloperidol (2.5 mg 3 times daily plus 2.5 mg as needed up to a total maximum daily dose of 20 mg) or placebo. (nih.gov)
A total of 22 were randomized to receive 2.5 mg of intravenous haloperidol (half the usual dose) and 26 to receive 4 mg of IV ondansetron. (medpagetoday.com)
Examination of baseline risk factors for QTc interval prolongation in patients prescribed intravenous haloperidol. (duke.edu)
BACKGROUND: Intravenous haloperidol can increase the risk for corrected QT interval (QTc) prolongation, torsades de pointes (TdP) and sudden death. (duke.edu)
There are a number of risk factors reported in the literature for QTc prolongation and TdP with intravenous haloperidol. (duke.edu)
OBJECTIVE: The purpose of this study was to determine the prevalence of baseline risk factors for QTc prolongation and TdP in hospitalized medical inpatients prescribed intravenous haloperidol. (duke.edu)
METHODS: This is a retrospective cohort study of medically ill hospitalized inpatients prescribed intravenous haloperidol between 30 June 2007 and 1 January 2010. (duke.edu)
RESULTS: A total of 175 subjects were identified as receiving intravenous haloperidol during the study period. (duke.edu)
Following intravenous haloperidol administration, 46.9% of subjects had a follow-up ECG obtained within 24 hours. (duke.edu)
At the time of intravenous haloperidol administration, 93.1% of subjects had a potassium value available and 62.9% had a magnesium value. (duke.edu)
Of the 175 subjects, 43.4% were taking ≥1 concomitant QTc prolongation medication at the time of intravenous haloperidol administration. (duke.edu)
CONCLUSIONS: Consistent with previously published reports, patients in this study prescribed intravenous haloperidol had multiple risk factors, both modifiable and non-modifiable, at baseline for QTc prolongation and TdP. (duke.edu)
The modifiable risk factors may be important targets of interventions aimed at optimizing the safety of the use of intravenous haloperidol, while the non-modifiable risk factors may warrant closer scrutiny with consideration of alternative therapies and continuous monitoring. (duke.edu)

Available antiemetics, such as phenothiazines (chlorpromazine and prochlorperazine) and substituted benzamides (metoclopramide), were known to affect these receptors, as were butyrophenones (haloperidol and droperidol). (cancernetwork.com)
A rare but Internet for reviews of Cipro is to consult with as chlorpromazine, haloperidol, professional. (sportsintegrityinitiative.com)

Haloperidol is not approved for the treatment of patients with dementia-related psychosis (see WARNINGS ). (nih.gov)
Haloperidol is not approved for use in older adults with dementia-related psychosis. (uofmhealth.org)
Haloperidol may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. (uofmhealth.org)
Haloperidol works by blocking a chemical, called dopamine, in the brain to decrease symptoms of psychosis. (pocketpills.com)

Haloperidol and other typical ND act on the D2 subset of dopamine receptors. (vin.com)
Haloperidol is a first-generation (typical antipsychotic) which exerts its antipsychotic action by blocking dopamine D2 receptors in the brain. (statpearls.com)
Haloperidol works by blocking the action of dopamine. (buy-pharma.md)
Acute blockade of dopamine D 2 receptors by the typical antipsychotic drug haloperidol leads to alterations in neuronal gene expression and behavior. (elsevier.com)
Dopamine guides competition for cognitive control: Common effects of haloperidol on working memory and response conflict. (ox.ac.uk)
Here, we examine the effect of haloperidol, principally a dopamine D2 receptor antagonist, on the ability of humans to ignore distracting information or update working memory contents. (ox.ac.uk)
The deleterious effect of haloperidol on response conflict was selectively associated with the negative effect of the drug on ignoring - but not updating - suggesting that dopamine affects protection of working memory contents and inhibition in response conflict through a common mechanism. (ox.ac.uk)

Your doctor will probably start you on a low dose of haloperidol and gradually increase your dose. (medlineplus.gov)
Halving the dose of haloperidol seemed to prevent common side effects of anxiety, sedation, and restlessness, McCoy added. (medpagetoday.com)

Most likely, you have used the form of haloperidol that is taken by mouth. (blinkhealth.com)
Your doctor is using this form of haloperidol so that you won't have to remember to take this medication every day. (blinkhealth.com)
This medication is the long-acting form of haloperidol. (blinkhealth.com)

The present experiments were undertaken to determine the effect of acute and long-term administration of haloperidol on the responsiveness of accumbens neurons to microiontophoretic applications of the sulfated cholecystokinin octapeptide (CCK-8S), kainate (KA), and DA and on the density of CCK, D1, and D2 receptors determined by radioautography. (jneurosci.org)
Acute administration of haloperidol (1 mg/kg, i.v.) did not modify the neuronal responsiveness to DA and KA but increased that to CCK-8S. (jneurosci.org)

Haloperidol is also used to treat severe behavioral problems such as explosive, aggressive behavior or hyperactivity in children who cannot be treated with psychotherapy or with other medications. (medlineplus.gov)
tell your doctor and pharmacist if you are allergic to haloperidol or any other medications. (medlineplus.gov)
Haloperidol is also used for severe behavior problems in hyperactive children when other treatments or medications have not worked. (healthwarehouse.com)
[ 2-6 ] These concerns, coupled with the importance of treating certain delirium symptoms acutely (e.g., agitation, delusions), result in the frequent administration of antipsychotic medications like haloperidol to treat delirium in the ICU. (medscape.com)
You could get Pms Haloperidol delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. (pocketpills.com)

To control acute agitation in a schizophrenic patient, dosing is 2 to 5 mg haloperidol intramuscularly every 4 to 8 hours. (statpearls.com)
Intramuscular injections of haloperidol can also be given to people with an acute psychotic attack or who are agitated or aggressive. (pocketpills.com)
An acute behavioral response to haloperidol is catalepsy, considered to be a rodent correlate of some of the immediate extrapyramidal motor side effects seen in humans. (elsevier.com)

It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine , haloperidol , and risperidone . (psychonautwiki.org)

To compare the utility of intramuscular lorazepam (LZ) with the combination of intramuscular haloperidol (HDL) and LZ to control acutely agitated behavior. (semanticscholar.org)

Haloperidol is a butyrophenone derivative with tranquilizer/antipsychotic properties that are effective in the management of hyperactivity, agitation, and anxiety in humans. (vin.com)
[ 12 ] Although haloperidol may help reduce agitation in critically ill adults with delirium, [ 10 ] the presence of agitation is not associated with increased mortality. (medscape.com)

Take haloperidol at around the same times every day. (medlineplus.gov)
Take haloperidol exactly as directed. (medlineplus.gov)
Continue to take haloperidol even if you feel well. (medlineplus.gov)
Your doctor will probably tell you not to take haloperidol. (medlineplus.gov)

McCoy said that while there has been concern that haloperidol prolongs the QT interval, the researchers found no sign of a difference between the drugs. (medpagetoday.com)
What other drugs will affect haloperidol? (uofmhealth.org)
Midazolam has a significantly shorter time to onset of sedation and a more rapid time to arousal than lorazepam or haloperidol, and the efficacies of all three drugs appear to be similar. (semanticscholar.org)

Haloperidol is supplied as tablets for oral administration containing 0.5 mg, 1 mg, 2 mg, 5 mg, 10 mg or 20 mg of haloperidol, USP and contains the following inactive ingredients: magnesium stearate, microcrystalline cellulose, pregelatinized starch. (nih.gov)
Haloperidol tablets, USP are indicated for use in the management of manifestations of psychotic disorders. (nih.gov)
Haloperidol tablets, USP are indicated for the control of tics and vocal utterances of Tourette's Disorder in children and adults. (nih.gov)
Haloperidol tablets, USP are effective for the treatment of severe behavior problems in children of combative, explosive hyperexcitability (which cannot be accounted for by immediate provocation). (nih.gov)
Haloperidol tablets, USP are also effective in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance. (nih.gov)
Haloperidol tablets should be taken with food or milk to avoid stomach upset. (pocketpills.com)

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol. (aspetjournals.org)
Since haloperidol does not block β-adrenergic receptors and the ophthalmic dose required to lower IOP is only 6.5% of the antipsychotic dose, haloperidol might be a good drug for glaucoma treatment with the possibility of minimal side effects. (jamanetwork.com)
We hypothesize that both striatal gene induction and catalepsy elicited by haloperidol arise from the combined effect of excitatory adenosinergic and glutamatergic inputs acting at adenosine A(2A) and N-methyl-D-aspartate (NMDA) receptors, respectively. (elsevier.com)
We show here that blocking both A(2A) and NMDA receptors simultaneously in conjunction with haloperidol resulted in a combined effect on gene expression and behavior that was greater than that for block of either receptor alone. (elsevier.com)
These results indicate that the haloperidol-induced increases in c-fos and NT gene expression in the dorsolateral striatum and catalepsy are driven largely by adenosine and glutamatergic inputs acting at A(2A) and NMDA receptors. (elsevier.com)
Chartoff, EH, Ward, RP & Dorsa, DM 1999, ' Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy ', Journal of Pharmacology and Experimental Therapeutics , vol. 291, no. 2, pp. 531-537. (elsevier.com)

Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking haloperidol. (medlineplus.gov)
Haloperidol injection may also be used for purposes not listed in this medication guide. (uofmhealth.org)
Haloperidol is a first-generation (typical) antipsychotic medication used widely around the world. (statpearls.com)
Haloperidol is a psychiatric medication (antipsychotic-type) that works by helping to restore the balance of certain natural substances in the brain (neurotransmitters). (healthwarehouse.com)
Your doctor may prescribe another medication for you to take with haloperidol to decrease these side effects. (blinkhealth.com)
Switch medication from Paliperidone to Haloperidol . (psychiatrienet.nl)
A common maneuver is rolling the patient in the lateral decubitus position, performing a jaw thrust, and suctioning the airway (Choice C). Administration of IM haloperidol (Choice A) is unlikely to terminate the seizure as it is an antipsychotic, not an antiepileptic medication. (iem-student.org)
Haloperidol is the most effective medication. (ni365.blog)

Haloperidol or placebo was administered in the ICU for as long as delirium continued and as needed for recurrences. (nih.gov)
510 were assigned to the haloperidol group and 490 to the placebo group. (nih.gov)
Among these patients, 987 (98.7%) were included in the final analyses (501 in the haloperidol group and 486 in the placebo group). (nih.gov)
At 90 days, the mean number of days alive and out of the hospital was 35.8 (95% confidence interval [CI], 32.9 to 38.6) in the haloperidol group and 32.9 (95% CI, 29.9 to 35.8) in the placebo group, with an adjusted mean difference of 2.9 days (95% CI, -1.2 to 7.0) (P = 0.22). (nih.gov)
Serious adverse reactions occurred in 11 patients in the haloperidol group and in 9 patients in the placebo group. (nih.gov)
Among patients in the ICU with delirium, treatment with haloperidol did not lead to a significantly greater number of days alive and out of the hospital at 90 days than placebo. (nih.gov)
Patients received preventive haloperidol or placebo for up to 28 days until delirium occurrence, death, or ICU discharge. (medscape.com)
Participants completed the functional MRI task on three separate occasions (in randomised order): following placebo, haloperidol, and aripiprazole. (kcl.ac.uk)
However, reaction time to a correct response was significantly increased following aripiprazole compared to both placebo (p=0.046) and haloperidol (p=0.02). (kcl.ac.uk)
Haloperidol had no effect on working memory performance compared with placebo. (kcl.ac.uk)

Haloperidol is the first of the butyrophenone series of major tranquilizers. (nih.gov)
Haloperidol is a butyrophenone antipsychotic drug that has strong central antidopaminergic activity. (internetpdfarticles.com)

Haloperidol injection is sometimes used in people who are unable to take the medicine by mouth. (uofmhealth.org)
How is haloperidol injection given? (uofmhealth.org)
You may be given oral haloperidol to take by mouth for a short time before you are treated with haloperidol injection. (uofmhealth.org)
Call your doctor for instructions if you miss an appointment for your haloperidol injection. (uofmhealth.org)
10,13 Haloperidol lactate injection (Bedford Laboratories, Bedford, OH, USA) is routinely used at the San Diego Wild Animal Park (SDWAP) when relocating non-domestic hoofstock animals to new enclosures, the hospital or holding facilities. (vin.com)
The starting dose of the injection depends on the dose of oral haloperidol the person was previously taking. (pocketpills.com)
For some people who start using the long-acting injection, they may be taking both the oral and injection forms of haloperidol at the same time. (pocketpills.com)

Haloperidol is used to treat psychotic disorders (conditions that cause difficulty telling the difference between things or ideas that are real and things or ideas that are not real). (medlineplus.gov)

Haloperidol is also used to control motor tics (uncontrollable need to repeat certain body movements) and verbal tics (uncontrollable need to repeat sounds or words) in adults and children who have Tourette's disorder (condition characterized by motor or verbal tics). (medlineplus.gov)
Haloperidol is also used to control motor and speech tics in people with Tourette's syndrome. (uofmhealth.org)

In the authors' practice, it is not unusual to observe clinically significant adverse reactions to haloperidol in non-domestic hoofstock. (vin.com)
Of the 58 patients exposed only to NT dosages of haloperidol, 72% clinically recovered within the 5-week trial. (elsevier.com)

5,6,11 Haloperidol lactate is likely the most common short-acting ND used in zoological institutions in the United States and has been successfully used in thousands of hoofstock in the author's practice. (vin.com)
Haloperidol lactate is available in a short-acting parenteral solution (5 mg/mL) injected intramuscularly. (statpearls.com)

SAN FRANCISCO - Haloperidol may be a better option than the old standby ondansetron to treat certain patients with vomiting and nausea in the emergency department (ED), according to a small double-blind, randomized study presented here. (medpagetoday.com)
At 90 minutes, median abdominal pain Visual Analogue Scale (VAS) score fell from 5 to 0 in the patients who received haloperidol compared with a VAS score drop from 6 to 3.5 in the ondansetron group ( P =0.0006), reported Jessica McCoy, MD, of Western Michigan University Homer Stryker School of Medicine in Kalamazoo. (medpagetoday.com)
Also at 90 minutes, median nausea VAS score fell from 7 to 0.5 in the haloperidol group versus 6 to 3.5 in the ondansetron group ( P =0.0178), data presented at the American College of Emergency Physicians annual meeting showed. (medpagetoday.com)
Adverse effects, which resolved by the time of discharge from the ED, included three cases of anxiety/restlessness and one case of tongue swelling in the haloperidol group and single cases of restlessness, sleepiness, and irritated throat in the ondansetron group. (medpagetoday.com)
McCoy noted that the ED physicians at her institution continue to turn to alternatives to ondansetron such as haloperidol in appropriate cases, especially in patients with anxiety. (medpagetoday.com)
Like ondansetron, haloperidol is inexpensive, she added. (medpagetoday.com)
The objective of this work is to study the stability of solutions of ondansetron and haloperidol at different concentrations and temperatures all prepared in 0.9% NaCl and stored in infusors, with all cases protected from light. (bmj.com)
The concentrations of the admixtures were 0.15-0.25 mg/mL and 0.3-0.4 mg/mL of haloperidol and ondansetron, respectively, with a storage temperature of 25°C and 37°C. (bmj.com)

Haloperidol is a first-generation (typical) antipsychotic that is a commonly used drug worldwide. (statpearls.com)
Fluphenazine is a high-potency typical antipsychotic with pharmacology similar to that of haloperidol. (medscape.com)

Haloperidol is frequently used to treat delirium in patients in the intensive care unit (ICU), but evidence of its effect is limited. (nih.gov)

Relationship between CYP2D6 genotype and haloperidol pharmacokinetics and extrapyramidal symptoms in healthy volunteers. (cdc.gov)

For the ongoing treatment of psychiatric disorders, long-acting haloperidol injections are used to help decrease the number of pills some people have to take. (pocketpills.com)

Haloperidol is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. (medlineplus.gov)
Be sure to tell your doctor how you are feeling during your treatment with haloperidol. (medlineplus.gov)
Among the 29 cannabis users in the study, haloperidol was not found to be superior at 90 minutes post-treatment, she said. (medpagetoday.com)
McCoy said the new study follows up on her previous research showing that haloperidol had benefit as a treatment for severe benign headache. (medpagetoday.com)
No significant associations were found between AIP and the remaining selected polymorphisms.Although validation is needed, this study suggests that carriership of the -759 T allele of the HTR2C gene in females may be protective against development of parkinsonism in elderly patients during treatment with haloperidol. (eur.nl)
If delirium occurred, treatment with open-label IV haloperidol 2 mg tid (up to 5 mg tid per delirium symptoms) was administered at clinician discretion. (medscape.com)
A total of 477 of 542 (88%) received treatment haloperidol (2.1 mg [1.0-3.8 mg] daily) for 6 days (3-11 d). (medscape.com)
Treatment haloperidol administered later in the ICU course was less protective of death. (medscape.com)
Results were stable by prevention study-arm, predelirium haloperidol exposure, and haloperidol treatment protocol adherence. (medscape.com)
Treatment of incident delirium and its symptoms with haloperidol may be associated with a dose-dependent improvement in survival. (medscape.com)
A recent practice guideline recommends haloperidol should not be routinely administered for ICU delirium treatment. (medscape.com)
[ 15 ] Prior ICU haloperidol delirium treatment randomized trials have enrolled patients with both prevalent and incident delirium. (medscape.com)

Haloperidol is commonly administered in the ICU to reduce the burden of delirium and its related symptoms despite no clear evidence showing haloperidol helps to resolve delirium or improve survival. (medscape.com)
We evaluated the association between haloperidol, when used to treat incident ICU delirium and its symptoms, and mortality. (medscape.com)
[ 16 ] A delay to the initiation of haloperidol after delirium occurrence may be greater with prevalent delirium than incident delirium particularly when delirium first occurs prior to ICU admission. (medscape.com)

d) an adult Asian bull was given 100 mg haloperidol orally bid. (elephantcare.org)
So the animal was put on 100 mg haloperidol twice daily orally. (elephantcare.org)
In moderately severe patients, dosing is 0.5 to 2 mg haloperidol orally 2 to 3 times a day. (statpearls.com)

We have studied the expression of its encoding mRNA in the brains of rats treated with haloperidol (2 mg kg-1 d-1) for two weeks. (ox.ac.uk)

Our study provides evidence for immediate and differential effects of single-dose haloperidol and aripiprazole on brain activation during working memory in healthy individuals. (kcl.ac.uk)

Cases of sudden death, QT-prolongation, and Torsades de pointes have been reported in patients receiving haloperidol. (nih.gov)
Haloperidol] is definitely a drug that's going to help young patients with benign abdomens who come in with vomiting and generalized abdominal pain," she told MedPage Today . (medpagetoday.com)
Haloperidol, however, is not appropriate, she cautioned, for more complex cases such as patients with rigid abdomens, possible dissections, or who have a need for surgery. (medpagetoday.com)
A prospective, double-blind, randomized trial of midazolam versus haloperidol versus lorazepam in the chemical restraint of violent and severely agitated patients. (semanticscholar.org)
The aim of this study was to investigate whether previous identified and studied genetic polymorphisms at DRD2, ANKK1, DRD3, HTR2A, HTR2C, RGS2, COMT, and BDNF genes are associated with antipsychotic-related parkinsonism in elderly patients.This cross-sectional study included 150 inpatients aged 65 years and older who were treated with haloperidol. (eur.nl)
The remaining 95 responding or nonresponding patients were then randomly assigned, double-blind, to a dosage of haloperidol two to 10 times higher (mean, 11.6 ±4.7 mg/d) or to a continuing NT dosage (mean, 3.4±2.3 mg/d) for another 2 weeks. (elsevier.com)
RESUME Afin d'examiner l'expérience d'une clinique de pédopsychiatrie en ce qui concerne la comorbidité et les caractéristiques du traitement des enfants souffrant d'hyperactivité avec déficit de l'attention (HADA), une étude rétrospective a été réalisée auprès des patients de moins de 19 ans qui consultaient à la clinique et chez lesquels un diagnostic de HADA avait été posé. (who.int)

Severe behavioral disorders in children: Haloperidol is effective for treating combative and explosive hyperexcitability (which cannot be accounted for by immediate provocation). (statpearls.com)
Haloperidol is no longer routinely used as initial therapy for behavioral disorders but may be necessary in refractory or complex cases. (statpearls.com)

Do not stop using haloperidol suddenly after long-term use , or you could have unpleasant withdrawal symptoms. (uofmhealth.org)
Hyperactivity: Haloperidol is effective for children with excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance. (statpearls.com)
Do not give Pms Haloperidol to anyone else, even if they have the same symptoms as you do. (pocketpills.com)

Haloperidol can also be used to treat uncontrolled movements and outbursts of words/sounds related to Tourette\'s syndrome. (healthwarehouse.com)

Haloperidol is a medicinal drug with antipsychotic, neuroleptic, and antiemetic activities. (thetopmedstore.com)

Haloperidol, a dopaminergic antagonist, was found to be very effective in suppressing the intraocular pressure recovery curve of rabbits infused with 20% saline intravenously. (jamanetwork.com)

Excellent reviews of the use and pharmacology of long-acting ND in non-domestic species have been written 10,11 and are appropriate for understanding shorter-acting ND, such as haloperidol. (vin.com)

Haloperidol is also used to treat confusion and difficulty thinking and understanding that is caused by severe physical or mental illness. (medlineplus.gov)

Describe the adverse effects of haloperidol. (statpearls.com)

For children 6 to 12 years old, the usual starting dose of oral haloperidol ranges from 0.25 mg to 0.5 mg taken 2 to 3 times a day. (pocketpills.com)

Use a concentration of 0.156 µg/ml. 2ng/ml Haloperidol produces 95% inhibition in a competitive Use a concentration of 0.156 µg/ml. ab123971 is suitable for the Development of Rapid tests and other immunoassay, antibody recognition assays. (internetpdfarticles.com)

Striatal synaptophysin expression and haloperidol-induced synaptic plasticity. (ox.ac.uk)

The concentrations of the drug, haloperidol, the enhancer, farnesol and the gelator, GP-1 are 3 mg/ml, 5% (w/v) and 5% (w/v), respectively. (nus.edu.sg)
Drug-induced pneumonitis associated with haloperidol. (elsevier.com)
Your doctor may have suggested Pms Haloperidol for conditions other than those listed in these drug information articles. (pocketpills.com)

[11] Haloperidol is not selective for the D2 receptor. (statpearls.com)
In agreement with other reports, the noncompetitive NMDA receptor antagonist MK-801 also reduced gene expression and catalepsy in response to haloperidol. (elsevier.com)
The competitive NMDA receptor antagonist LY235959 decreased haloperidol-induced catalepsy. (elsevier.com)

Anatomy1

Organisms1

Diseases4

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Psychiatry and Psychology7

Phenomena and Processes4

Health Care1

S-16924 [(R)-2-[1-[2-(2,3-dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]- pyrrolidin-3yl]-1-(4-fluorophenyl)-ethanone], a novel, potential antipsychotic with marked serotonin1A agonist properties: III. Anxiolytic actions in comparison with clozapine and haloperidol. (1/1058)

Ergoline derivative LEK-8829-induced turning behavior in rats with unilateral striatal ibotenic acid lesions: interaction with bromocriptine. (2/1058)

Behavioral, toxic, and neurochemical effects of sydnocarb, a novel psychomotor stimulant: comparisons with methamphetamine. (3/1058)

Effect of psychotropic drugs on caudate spindle in cats. (4/1058)

Comparison of effects of haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. (5/1058)

Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line. (6/1058)

Synergistic interactions between ampakines and antipsychotic drugs. (7/1058)

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site. (8/1058)

Haloperidol

Antipsychotic Agents

Clozapine

Catalepsy

Dopamine Antagonists

Risperidone

Receptors, Dopamine D2

Apomorphine

Benzodiazepines

Receptors, Dopamine

Promethazine

Tranquilizing Agents

Psychomotor Agitation

Sulpiride

Dopamine

Pimozide

Fluphenazine

Receptors, sigma

Thioridazine

Schizophrenia

Dopamine Agonists

Chlorpromazine

Phencyclidine

Trifluperidol

Emergency Services, Psychiatric

Dibenzothiazepines

Stereotyped Behavior

Receptors, Dopamine D3

Pirenzepine

Neurotensin

Phenazocine

Spiperone

Pentazocine

Clopenthixol

Dose-Response Relationship, Drug

Ritanserin

Corpus Striatum

Remoxipride

Butyrophenones

Butaclamol

Homovanillic Acid

Rats, Sprague-Dawley

Startle Reaction

Anti-Dyskinesia Agents

Motor Activity

Quinpirole

Basal Ganglia Diseases

Receptors, Phencyclidine

Clorazepate Dipotassium

Pyrrolidines

Dibenzothiepins

Serotonin Receptor Agonists

Delirium

Serotonin Antagonists

Chlordiazepoxide

Amphetamine

Dextroamphetamine

3,4-Dihydroxyphenylacetic Acid

Drug Interactions

Bromocriptine

S-16924 [(R)-2-[1-[2-(2,3-dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]- pyrrolidin-3yl]-1-(4-fluorophenyl)-ethanone], a novel, potential antipsychotic with marked serotonin1A agonist properties: III. Anxiolytic actions in comparison with clozapine and haloperidol. (1/1058)

Ergoline derivative LEK-8829-induced turning behavior in rats with unilateral striatal ibotenic acid lesions: interaction with bromocriptine. (2/1058)

Behavioral, toxic, and neurochemical effects of sydnocarb, a novel psychomotor stimulant: comparisons with methamphetamine. (3/1058)

Effect of psychotropic drugs on caudate spindle in cats. (4/1058)

Comparison of effects of haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. (5/1058)

Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line. (6/1058)

Synergistic interactions between ampakines and antipsychotic drugs. (7/1058)

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site. (8/1058)

Depolarization inactivation of dopamine neurons: Terminal release characteristics<...

Influence of acute and chronic haloperidol treatment on dopamine metabolism in the rat caudate-putamen, prefrontal cortex and...

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