Half life. Medical search

The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.

Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.

A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.

A condition resulting from the excessive retention of water with sodium depletion.

Strong alkaline chemicals that destroy soft body tissues resulting in a deep, penetrating type of burn, in contrast to corrosives, that result in a more superficial type of damage via chemical means or inflammation. Caustics are usually hydroxides of light metals. SODIUM HYDROXIDE and potassium hydroxide are the most widely used caustic agents in industry. Medically, they have been used externally to remove diseased or dead tissues and destroy warts and small tumors. The accidental ingestion of products (household and industrial) containing caustic ingredients results in thousands of injuries per year.

An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)

Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.

Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.

The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.

The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)

The rate dynamics in chemical or physical systems.

Injections made into a vein for therapeutic or experimental purposes.

Elements of limited time intervals, contributing to particular results or situations.

The giving of drugs, chemicals, or other substances by mouth.

Dynamic and kinetic mechanisms of exogenous chemical and DRUG LIBERATION; ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and DRUG TOXICITY as a function of dosage, and rate of METABOLISM. LADMER, ADME and ADMET are abbreviations for liberation, absorption, distribution, metabolism, elimination, and toxicology.

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.

A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)

The state that distinguishes organisms from inorganic matter, manifested by growth, metabolism, reproduction, and adaptation. It includes the course of existence, the sum of experiences, the mode of existing, or the fact of being. Over the centuries inquiries into the nature of life have crossed the boundaries from philosophy to biology, forensic medicine, anthropology, etc., in creative as well as scientific literature. (Random House Unabridged Dictionary, 2d ed; Dr. James H. Cassedy, NLM History of Medicine Division)

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.

A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.

The extent to which an enzyme retains its structural conformation or its activity when subjected to storage, isolation, and purification or various other physical or chemical manipulations, including proteolytic enzymes and heat.

Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.

The relationship between the dose of an administered drug and the response of the organism to the drug.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Those occurrences, including social, psychological, and environmental, which require an adjustment or effect a change in an individual's pattern of living.

Established cell cultures that have the potential to propagate indefinitely.

The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.

Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.

Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.

Care provided patients requiring extraordinary therapeutic measures in order to sustain and prolong life.

Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)

The normal length of time of an organism's life.

The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.

A quality-of-life scale developed in the United States in 1972 as a measure of health status or dysfunction generated by a disease. It is a behaviorally based questionnaire for patients and addresses activities such as sleep and rest, mobility, recreation, home management, emotional behavior, social interaction, and the like. It measures the patient's perceived health status and is sensitive enough to detect changes or differences in health status occurring over time or between groups. (From Medical Care, vol.xix, no.8, August 1981, p.787-805)

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.

Insurance providing for payment of a stipulated sum to a designated beneficiary upon death of the insured.

Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

The performance of the basic activities of self care, such as dressing, ambulation, or eating.

The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Stress wherein emotional factors predominate.

The individual's experience of a sense of fulfillment of a need or want and the quality or state of being satisfied.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Assessment of psychological variables by the application of mathematical procedures.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

The measurement of the health status for a given population using a variety of indices, including morbidity, mortality, and available health resources.

The origin of life. It includes studies of the potential basis for life in organic compounds but excludes studies of the development of altered forms of life through mutation and natural selection, which is BIOLOGICAL EVOLUTION.

A state of harmony between internal needs and external demands and the processes used in achieving this condition. (From APA Thesaurus of Psychological Index Terms, 8th ed)

Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.

Social and economic factors that characterize the individual or group within the social structure.

A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

Systems that provide all or most of the items necessary for maintaining life and health. Provisions are made for the supplying of oxygen, food, water, temperature and pressure control, disposition of carbon dioxide and body waste. The milieu may be a spacecraft, a submarine, or the surface of the moon. In medical care, usually under hospital conditions, LIFE SUPPORT CARE is available. (From Webster's New Collegiate Dictionary)

The bioavailability, dispostion kinetics and dosage of sulphadimethoxine in dogs. (1/6090)

The disposition kinetics of sulphadimethoxine were studied in six normal beagle dogs after intravenous injection of a single dose (55 mg/kg). The median (range) distribution and elimination half times of the drug were 2.36 (2.06-3.35) hours and 13.10 (9.71-16.50) hours, respectively. Total body clearance of the drug had a median value of 21.7 ml/kg/h and a mean value of 21.4 ml/kg/h. While the overall tissue to plasma level ratio (k12/k21) of the drug was 0.55 after distribution equilibrium had been attained, analogue computer simulated curves showed that at 24 hours the fractions (percentage) of the dose in the central and tissue compartments were 12 and 11%, respectively. The drug was shown, by equilibrium dialysis method, to be highly bound to plasma proteins (greater than 75%) within the usual therapeutic range (50 to 150 mug/ml) of plasma levels. The systemic availability of sulphadimethoxine from the oral suspension was 32.8% (22.5-80.0). Since the absorption half time, 1.87 (0.86-3.22) hours, was considerably shorter than the half-life, 13.10 (9.71-16.50) hours, of the drug, the rate of absorption would have little influence on the dosage regimen. Based on the experimental data obtained, a satisfactory dosage regimen might consist of a priming dose of 55 mg/kg by the intravenous route and maintenance doses of either 27.5 mg/kg of sulphadimethoxine injection given intravenously or 55 mg/kg of the oral suspension administered at 24 hour intervals. The adequacy and duration of therapy will depend upon the clinical response obtained. (+info)

Cocaine metabolite kinetics in the newborn. (2/6090)

The study goal was to determine the half-life elimination of cocaine and benzoylecgonine (BZE) in the newborn. Three 0.3-mL blood samples were collected during the first day of life. Urine was collected once daily. Cocaine and BZE concentrations were determined by gas chromatography-mass spectrometry. An extraction method was developed for measuring low concentrations of cocaine and BZE in small (0.1 mL) blood samples. Cocaine had a half-life of 11.6 h in one subject. The half-life of BZE during the first day of life, based on blood data in 13 subjects, was 16 h (95% confidence interval [CI], 12.8 to 21.4 h). The half-life of BZE during the first week of life, based on urine data in 16 subjects, was 11.2 h (95% CI, 10.1 to 11.8 h). The novel extraction method for small blood sample volumes should be applicable to other basic drugs. (+info)

Re-entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species. (3/6090)

Misfolded or unassembled secretory proteins are retained in the endoplasmic reticulum (ER) and subsequently degraded by the cytosolic ubiquitin-proteasome system. This requires their retrograde transport from the ER lumen into the cytosol, which is mediated by the Sec61 translocon. It had remained a mystery whether ER-localised soluble proteins are at all capable of re-entering the Sec61 channel de novo or whether a permanent contact of the imported protein with the translocon is a prerequisite for retrograde transport. In this study we analysed two new variants of the mutated yeast carboxypeptidase yscY, CPY*: a carboxy-terminal fusion protein of CPY* and pig liver esterase and a CPY* species carrying an additional glycosylation site at its carboxy-terminus. With these constructs it can be demonstrated that the newly synthesised CPY* chain is not retained in the translocation channel but reaches its ER lumenal side completely. Our data indicate that the Sec61 channel provides the essential pore for protein transport through the ER membrane in either direction; persistent contact with the translocon after import seems not to be required for retrograde transport. (+info)

Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. (4/6090)

The long-term administration of L-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue. After i.p. injection of L-carnitine, the concentration of free carnitine in heart remained constant, although serum free carnitine level increased up to 80-fold. On the other hand, a significant increase in short-chain acyl-carnitine level in heart was observed. These results suggest that increased levels of short-chain acyl-carnitine, not free carnitine, might be a key compound in the protective effect of L-carnitine administration in JVS mice. (+info)

Protection against lymphocytic choriomeningitis virus infection induced by a reduced peptide bond analogue of the H-2Db-restricted CD8(+) T cell epitope GP33. (5/6090)

Recent investigations have suggested that pseudopeptides containing modified peptide bonds might advantageously replace natural peptides in therapeutic strategies. We have generated eight reduced peptide bond Psi(CH2-NH) analogues corresponding to the H-2Db-restricted CD8(+) T cell epitope (called GP33) of the glycoprotein of the lymphocytic choriomeningitis virus. One of these pseudopeptides, containing a reduced peptide bond between residues 6 and 7 (Psi(6-7)), displayed very similar properties of binding to major histocompatibility complex (MHC) and recognition by T cell receptor transgenic T cells specific for GP33 when compared with the parent peptide. We assessed in vitro and in vivo the proteolytic resistance of GP33 and Psi(6-7) and analyzed its contribution to the priming properties of these peptides. The Psi(6-7) analogue exhibited a dramatically increased proteolytic resistance when compared with GP33, and we show for the first time that MHC-peptide complexes formed in vivo with a pseudopeptide display a sustained half-life compared with the complexes formed with the natural peptide. Furthermore, in contrast to immunizations with GP33, three injections of Psi(6-7) in saline induced significant antiviral protection in mice. The enhanced ability of Psi(6-7) to induce antiviral protection may result from the higher stability of the analogue and/or of the MHC-analogue complexes. (+info)

In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. (6/6090)

The widely used anticancer prodrug cyclophosphamide (CPA) is activated in liver by a 4-hydroxylation reaction primarily catalyzed by cytochrome P-4502B and P-4502C enzymes. An alternative metabolic pathway involves CPA N-dechloroethylation to yield chloroacetaldehyde (CA), a P-4503A-catalyzed deactivation/neurotoxication reaction. The in vivo modulation of these alternative, competing pathways of P-450 metabolism was investigated in pharmacokinetic studies carried out in the rat model. Peak plasma concentrations (Cmax) for 4-OH-CPA and CA were increased by 3- to 4-fold, and apparent plasma half-lives of both metabolites were correspondingly shortened in rats pretreated with phenobarbital (PB), an inducer of P-4502B and P-4503A enzymes. However, PB had no net impact on the extent of drug activation or its partitioning between these alternative metabolic pathways, as judged from AUC values (area-under-the-plasma concentration x time curve) for 4-OH-CPA and CA. The P-4503A inhibitor troleandomycin (TAO) decreased plasma Cmax and AUC of CA (80-85% decrease) without changing the Cmax or AUC of 4-OH-CPA in uninduced rats. In PB-induced rats, TAO decreased AUCCA by 73%, whereas it increased AUC4-OH-CPA by 93%. TAO thus selectively suppresses CPA N-dechloroethylation, thereby increasing the availability of drug for P-450 activation via 4-hydroxylation. By contrast, dexamethasone, a P-4503A inducer and antiemetic widely used in patients with cancer, stimulated large, undesirable increases in the Cmax and AUC of CA (8- and 4-fold, respectively) while reducing the AUC of the 4-hydroxylation pathway by approximately 60%. Tumor excision/in vitro colony formation and tumor growth delay assays using an in vivo 9L gliosarcoma solid tumor model revealed that TAO suppression of CPA N-dechloroethylation could be achieved without compromising the antitumor effect of CPA. The combination of PB with TAO did not, however, enhance the antitumor activity of CPA, despite the approximately 2-fold increase in AUC4-OH-CPA, suggesting that other PB-inducible activities, such as aldehyde dehydrogenase, may counter this increase through enhanced deactivation of the 4-hydroxy metabolite. Together, these studies demonstrate that the P-4503A inhibitor TAO can be used to effectively modulate CPA metabolism and pharmacokinetics in vivo in a manner that decreases the formation of toxic metabolites that do not contribute to antitumor activity. (+info)

Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model. (7/6090)

The effect of inoculum size (N0) on antimicrobial action has not been extensively studied in in vitro dynamic models. To investigate this effect and its predictability, killing and regrowth kinetics of Staphylococcus aureus and Escherichia coli exposed to monoexponentially decreasing concentrations of trovafloxacin (as a single dose) and ciprofloxacin (two doses at a 12-h interval) were compared at N0 = 10(6) and 10(9) CFU/ml (S. aureus) and at N0 = 10(6), 10(7), and 10(9) CFU/ml (E. coli). A series of pharmacokinetic profiles of trovafloxacin and ciprofloxacin with respective half-lives of 9.2 and 4 h were simulated at different ratios of area under the concentration-time curve (AUC) to MIC (in [micrograms x hours/milliliter]/[micrograms/milliliter]): 58 to 466 with trovafloxacin and 116 to 932 with ciprofloxacin for S. aureus and 58 to 233 and 116 to 466 for E. coli, respectively. Although the effect of N0 was more pronounced for E. coli than for S. aureus, only a minor increase in minimum numbers of surviving bacteria and an almost negligible delay in their regrowth were associated with an increase of the N0 for both organisms. The N0-induced reductions of the intensity of the antimicrobial effect (IE, area between control growth and the killing-regrowth curves) were also relatively small. However, the N0 effect could not be eliminated either by simple shifting of the time-kill curves obtained at higher N0s by the difference between the higher and lowest N0 or by operating with IEs determined within the N0-adopted upper limits of bacterial numbers (IE's). By using multivariate correlation and regression analyses, linear relationships between IE and log AUC/MIC and log N0 related to the respective mean values [(log AUC/MIC)average and (log N0)average] were established for both trovafloxacin and ciprofloxacin against each of the strains (r2 = 0.97 to 0.99). The antimicrobial effect may be accurately predicted at a given AUC/MIC of trovafloxacin or ciprofloxacin and at a given N0 based on the relationship IE = a + b [(log AUC/MIC)/(log AUC/MIC)average] - c [(log N0)/(log N0)average]. Moreover, the relative impacts of AUC/MIC and N0 on IE may be evaluated. Since the c/b ratios for trovafloxacin and ciprofloxacin against E. coli were much lower (0.3 to 0.4) than that for ampicillin-sulbactam as examined previously (1.9), the inoculum effect with the quinolones may be much less pronounced than with the beta-lactams. The described approach to the analysis of the inoculum effect in in vitro dynamic models might be useful in studies with other antibiotic classes. (+info)

Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. (8/6090)

Liposomal aminoglycosides have been shown to have activity against intracellular infections, such as those caused by Mycobacterium avium. Amikacin in small, low-clearance liposomes (MiKasome) also has curative and prophylactic efficacies against Pseudomonas aeruginosa and Klebsiella pneumoniae. To develop appropriate dosing regimens for low-clearance liposomal amikacin, we studied the pharmacokinetics of liposomal amikacin in plasma, the level of exposure of plasma to free amikacin, and urinary excretion of amikacin after the administration of single-dose (20 mg/kg of body weight) and repeated-dose (20 mg/kg eight times at 48-h intervals) regimens in rhesus monkeys. The clearance of liposomal amikacin (single-dose regimen, 0.023 +/- 0.003 ml min-1 kg-1; repeated-dose regimen, 0.014 +/- 0.001 ml min-1 kg-1) was over 100-fold lower than the creatinine clearance (an estimate of conventional amikacin clearance). Half-lives in plasma were longer than those reported for other amikacin formulations and declined during the elimination phase following administration of the last dose (from 81.7 +/- 27 to 30.5 +/- 5 h). Peak and trough (48 h) levels after repeated dosing reached 728 +/- 72 and 418 +/- 60 micrograms/ml, respectively. The levels in plasma remained > 180 micrograms/ml for 6 days after the administration of the last dose. The free amikacin concentration in plasma never exceeded 17.4 +/- 1 micrograms/ml and fell rapidly (half-life, 1.47 to 1.85 h) after the administration of each dose of liposomal amikacin. This and the low volume of distribution (45 ml/kg) indicate that the amikacin in plasma largely remained sequestered in long-circulating liposomes. Less than half the amikacin was recovered in the urine, suggesting that the level of renal exposure to filtered free amikacin was reduced, possibly as a result of intracellular uptake or the metabolism of liposomal amikacin. Thus, low-clearance liposomal amikacin could be administered at prolonged (2- to 7-day) intervals to achieve high levels of exposure to liposomal amikacin with minimal exposure to free amikacin. (+info)

... the second half-life is from 50% to 25%, and so on. A biological half-life or elimination half-life is the time it takes for a ... "first half-life", "second half-life", etc., where the first half-life is defined as the time required for decay from the ... Instead, the half-life is defined in terms of probability: "Half-life is the time required for exactly half of the entities to ... The biological half-life of caesium in human beings is between one and four months. The concept of a half-life has also been ...

https://en.wikipedia.org/wiki/Half-life

... half-life of the radionuclide, the two act as parallel paths for elimination of the radioactivity, the effective half-life ... Biological Half-life Biological Effects of Radiation ©1996, Kenneth R. Koehler. Half-life, effective, European Nuclear Society ... An effective half-life of the drug will involve a decay constant that represents the sum of the biological and physical decay ... It reflects the cumulative effect of the individual half-lives, as observed by the changes in the actual serum concentration of ...

https://en.wikipedia.org/wiki/Effective_half-life

The longer half-life is called the terminal half-life and the half-life of the largest component is called the dominant half- ... Biological half-life (also known as elimination half-life, pharmacologic half-life) is the time taken for concentration of a ... The half-life of a drug is the time required for the serum concentration to be reduced by 50%. Once the half-life of the drug ... Half life is also relative to the subjective metabolic rate of the individual in question. The biological half-life of caesium ...

https://en.wikipedia.org/wiki/Biological_half-life

"About Decay". Half-Life: Decay PC Port. Half-Life Creations. Retrieved September 26, 2008. Gearbox Software (2001). Half-Life: ... Half-Life: Decay is a multiplayer-only expansion pack for Valve's first-person shooter Half-Life. Developed by Gearbox Software ... "Reviews: Half-Life (PS2)". GameSpy. Archived from the original on July 9, 2008. Retrieved October 23, 2008. "Half-Life Q&A". ... Decay is set in the same location and timeframe as Half-Life. Half-Life takes place at a laboratory called the Black Mesa ...

https://en.wikipedia.org/wiki/Half-Life:_Decay

The final script ran to 280 pages, compared to 128 pages for Half-Life 2 and 18 for Half-Life. Valve announced Half-Life: Alyx ... Half-Life: Alyx takes place five years before the events of Half-Life 2. Earth has been conquered by the alien Combine, who ... "Half-Life: Alyx Cut Enemies That Were Too Scary In VR". GameSpot. Retrieved March 20, 2021. O'Connor, James. "Half-Life: Alyx ... "Original Half-Life Writer Was Very Involved In Half-Life: Alyx". Prima Games. Retrieved July 25, 2020. Kuchera, Ben (April 10, ...

https://en.wikipedia.org/wiki/Half-Life:_Alyx

Half-Life was the opening night film for the International Women's Film Festival in Seoul, Korea. The film made a theatrical ... Half-Life is a 2008 movie directed by Jennifer Phang, starring Sanoe Lake, Julia Nickson-Soul, Leonardo Nam, Ben Redgrave, Lee ... Official website Half-Life at IMDb v t e (Articles lacking reliable references from October 2009, All articles lacking reliable ... Their mother Saura (Nickson-Soul) struggles to make ends meet and move on with her life while involved with her manipulative ...

https://en.wikipedia.org/wiki/Half-Life_(film)

It was bundled with Half-Life in many subsequent packages, including Half-Life: Platinum Pack and Half-Life: Platinum. When ... Several Half-Life games have been canceled, including Half-Life 2: Episode Three, a version of Half-Life 3, and games developed ... Independent of Half-Life: Decay, which was bundled with the retail sales of the PlayStation 2 version of Half-Life. Chris Remo ... Half-Life: Counter-Strike spawned its own series which gradually became separate from the main Half-Life games, bar occasional ...

https://en.wikipedia.org/wiki/Half-Life_(series)

... is a game modification of Half-Life created by Russian developer Yuri "XF-Alien" Epifantsev, released on ... McGlynn, Arthur (May 8, 2021). "Half-Life spinoff mod years in the making coming this summer". PCGamesN. "Half-Life: Delta es ... "Half-Life: Delta is a new campaign mod a dozen years in the making". PC Gamer. Heaton, Andrew Paul (May 9, 2021). "Half-Life ... "A Russian developer has released a global mod for Half-Life - Delta. He created it for 12 years". GamingDeputy. McCawley, ...

https://en.wikipedia.org/wiki/Half-Life:_Delta

... may refer to: Half a Life (Bulychov book), a 1978 anthology of science fiction by Kir Bulychov Half a Life (film), ... Naipaul Half a Life (memoir), a 2011 memoir by Darin Strauss "Half a Life" (Star Trek: The Next Generation), a 1991 episode ... Half-life (disambiguation) This disambiguation page lists articles associated with the title Half a Life. If an internal link ... a 1982 film by Romain Goupil Half a Life (novel), a 2001 novel by V.S. ...

https://en.wikipedia.org/wiki/Half_a_Life

The mod uses voice lines from the original Half-Life, as well as Half-Life: Opposing Force, Half-Life: Blue Shift, Half-Life: ... "Half-Life: Echoes Mod Reimagines the First Game's Story". "Half-Life: Echoes". Namuwiki. "DÉCOUVREZ HALF-LIFE : ECHOES ET SON ... Half-Life: Echoes is a game modification of Half-Life created by British developer James "MrGnang" Coburn, released on August ... As a mod for Half-Life, Half-Life: Echoes is a first-person shooter that differs slightly from the base game. The first part of ...

https://en.wikipedia.org/wiki/Half-Life:_Echoes

In addition to the news, Planet Half-Life hosts extensive, in-depth collections of information regarding Half-Life, Half-Life 2 ... Half-Life: Deathmatch, Half-Life 2: Deathmatch and Team Fortress 2. However, currently only the Half-life 2: Deathmatch and Day ... Planet Half-Life Archives Planet Half-Life Planet Half-Life Forums (Webarchive template wayback links, Articles lacking ... Planet Half-Life also offers free web hosting for Half-Life themed websites. The web hosting is regulated through GameSpy, ...

https://en.wikipedia.org/wiki/Planet_Half-Life

"Nairobi Half Life: AFI Fest Review". The Hollywood Reporter. Retrieved 3 March 2016. "Nairobi Half Life: KenyaBuzz Movie Review ... Nairobi Half Life is a 2012 Kenyan drama film directed by David "Tosh" Gitonga. The film was selected as the Kenyan entry for ... "Nairobi Half-life, The Contract, Flower Girl win big at Africa Magic Viewers' Choice Awards - Premium Times Nigeria". Premium ... Nairobi Half Life at IMDb (Articles with short description, Short description is different from Wikidata, Use dmy dates from ...

https://en.wikipedia.org/wiki/Nairobi_Half_Life

... is a mod for the first-person shooter video game Half-Life. It strives to simulate action movies, especially ... Action Half-life". Rock, Paper, Shotgun. Retrieved 2017-07-04. Meer, Alec (June 8, 2009). "Action Half-Life 2: The Sauce Of ... "Action Half-Life: The 5AM". Rock, Paper, Shotgun. Retrieved 2016-11-09. Kosak, Dave (April 1, 2001). "Action Half-Life: Behind ... Action Half-Life is the second mod in the "Action" series. The first was Action Quake 2 and the third was Action Unreal ...

https://en.wikipedia.org/wiki/Action_Half-Life

Half-life, half life or halflife may also refer to: Half-Life (film), a 2008 independent film by Jennifer Phang Half Life: A ... Halflife (EP), an EP by Lacuna Coil and the title track Half-Life E.P., an EP by Local H "Half Life", a song by 10 Years from ... "Half Life", a song by Prototype from the album Trinity Halflives, (fl. 2016 -) an Italian alternative rock band Half-Life ( ... a video game series developed by Valve Half-Life (video game), the first game in the series Half-Life 2 the second game in the ...

https://en.wikipedia.org/wiki/Half-life_(disambiguation)

"Half-Life 2 Enemies". Planet Half-Life. IGN. Archived from the original on October 22, 2006. Retrieved 2008-09-23. "Half-Life 2 ... Half-Life: Alyx, which takes place between the events of Half-Life and Half-Life 2. The game focuses on the efforts of Alyx ... "Half-Life 2: Episode One Walkthrough-Chapter 1: Undue Alarm". Planet Half-Life. IGN. Archived from the original on October 10, ... "Half-Life 2: Episode One Walkthrough-Chapter 5: Exit 17". Planet Half-Life. IGN. Archived from the original on October 10, 2012 ...

https://en.wikipedia.org/wiki/Combine_(Half-Life)

The Soundtrack of Half-Life 2, containing most of the music from Half-Life 2 and many tracks from the original Half-Life, was ... Half-Life: Alyx. Like the original Half-Life (1998), Half-Life 2 is a single-player first-person shooter in which players ... Development of Half-Life 2 began in June 1999, six months after the release of the original Half-Life. It was developed by a ... Half-Life 2 was simultaneously released through Steam, CD, and on DVD in several editions. Through Steam, Half-Life 2 had three ...

https://en.wikipedia.org/wiki/Half-Life_2

Half-Life was published to critical acclaim by Alyson Books in 2004. Of Half-Life, Reed Business Information wrote "Gay readers ... Half-Life is a debut novel by Aaron Krach. Published in 2004 by Alyson Books, the novel was nominated for a Violet Quill Award ... Krach, Aaron (2004). Half-life: a novel. Alyson Books. ISBN 1-55583-854-5. OCLC 53971973. Retrieved October 26, 2009. Alyson ... Many of the familiar landmarks will remain-his best friend Dart riding shotgun; the suburban house where he lives with his dad ...

https://en.wikipedia.org/wiki/Half-Life_(Krach_novel)

The book Half-Life 2: Raising the Bar states that his appearance in Half-Life 2 is based on Frank Sheldon. The G-Man speaks in ... At the start of Half-Life 2, a Vortigaunt is seen speaking to the G-Man on a television. During the final chapter of Half-Life ... He also hints at having additional, unseen powers in Half-Life 2: Episode Two and Half-Life: Alyx. The G-Man expresses regret ... Half-Life 2 "Half-Life 2 Episode One - Opening Sequence HD (1080p)". GamingReviews. December 5, 2010. Archived from the ...

https://en.wikipedia.org/wiki/G-Man_(Half-Life)

... is an expansion pack for the first-person shooter game Half-Life. It was developed by Gearbox ... Archived official website Half-Life: Opposing Force at MobyGames Portals: 1990s Video Games Half-Life: Opposing Force at ... "Half-Life: Opposing Force Weapons". Planet Half-Life. GameSpy. Archived from the original on October 17, 2008. Retrieved ... "Half-Life: Generation". MobyGames. Retrieved April 1, 2016.[permanent dead link] "Half-Life 1: Anthology". IGN. Retrieved April ...

https://en.wikipedia.org/wiki/Half-Life:_Opposing_Force

It was followed by Half-Life 2 (2004), Half-Life 2: Episode One (2006), Half-Life 2: Episode Two (2007) and Half-Life: Alyx ( ... and Half-Life 2: Episode Two (2007). After cancelling a series of other Half-Life projects, Valve released Half-Life: Alyx in ... "breaks down pretty cleanly into pre-Half-Life and post-Half-Life eras". In 2021, the Guardian ranked Half-Life the third- ... Half-Life exited PC Data's monthly top 20 in June. Half-Life became the fifth-bestselling PC game of the first half of 1999 in ...

https://en.wikipedia.org/wiki/Half-Life_(video_game)

This is a list of characters in the Half-Life video game series, which comprises Half-Life, Half-Life 2, Half-Life: Alyx, and ... Barney Calhoun is the player character in Half-Life: Blue Shift and a major character in Half-Life 2 as well as Half-Life 2: ... The 2020 VR game Half-Life: Alyx, which takes place between the events of Half-Life and Half-Life 2, focuses on Eli and Alyx ... The 2020 VR title Half-Life: Alyx, which takes place between the events of Half-Life and Half-Life 2, focuses on Alyx and Eli ...

https://en.wikipedia.org/wiki/Characters_of_Half-Life

Half a Life is a 2001 novel by Nobel laureate V. S. Naipaul published by Alfred A. Knopf. The novel is set in India, Africa and ... Half a Life is a prequel to Naipaul's 2004 novel Magic Seeds which starts with Willie in Berlin. "V S Naipaul". Booker Prize. ... There he leads a life as a different man with an interesting background 'oriental' and fakes the facts of his life. Later in ... Half a Life was long listed for the Booker prize (2001). Willie Somerset Chandran is the son of a Brahmin father and a Dalit ...

https://en.wikipedia.org/wiki/Half_a_Life_(novel)

At the beginning of Half-Life, one such crystal, revealed in Half-Life 2: Episode Two to have been provided by the G-Man, is ... Valve (2005). Half-Life 2: Lost Coast (PC). Dulin, Ron (2008-11-20). "Half-Life for PC Review". GameSpot. Archived from the ... "Enemies of Half-Life 2". Planet Half-Life. Archived from the original on October 22, 2006. Retrieved 2015-06-24.{{cite web}}: ... "Half-Life 2 Walkthrough: Black Mesa East". Planet Half-Life. IGN. Archived from the original on 2012-11-13. Retrieved 2008-08- ...

https://en.wikipedia.org/wiki/Locations_of_Half-Life

"Half-Life Week, Day 2: The Half-Life Blues Shift". IGN. May 8, 2001. Retrieved October 26, 2008. Gearbox Software (2001). Half- ... Half-Life: Blue Shift is an expansion pack for the first-person shooter video game Half-Life (1998). It was developed by ... "Half-Life: Blue Shift Q&A". GameSpot. May 3, 2001. Retrieved October 26, 2008. Ajami, Amer (May 18, 2001). "E3 2001: Half-Life ... "Beta Half-Life for Sega Dreamcast". nextdimension. Retrieved July 28, 2013. Bramwell, Tom (August 25, 2005). "Free Half-Life 1 ...

https://en.wikipedia.org/wiki/Half-Life:_Blue_Shift

... is an EP released by Local H in 2001. It was released as a teaser for their album Here Comes the Zoo, which ... "Local H - Half-Life E.P." Discogs. (Articles with short description, Short description is different from Wikidata, Articles ... "Half-Life" (Scott Lucas, Brian St. Clair) - 3:39 "Static Age" (Glenn Danzig) - 2:42 "25 or 6 to 4" (Robert Lamm) - 3:51 "Stick ...

https://en.wikipedia.org/wiki/Half-Life_E.P.

Half a Life (French: Mourir à 30 ans) is a 1982 film directed by Romain Goupil, which won the Caméra d'Or and Award of the ... Half a Life at IMDb v t e v t e (Articles lacking sources from November 2014, All articles lacking sources, Articles with short ...

https://en.wikipedia.org/wiki/Half_a_Life_(film)

If an infusion has reached steady state then the context-sensitive half-life is equal to the terminal plasma half-life of the ... context-sensitive half-life is equal to elimination half-life Only free drug that is in the plasma is metabolised Metabolism ... context-sensitive half-life is shorter than elimination half-life Only free drug that is in the plasma is metabolised Overall ... Context-sensitive half-life or context sensitive half-time is defined as the time taken for blood plasma concentration of a ...

https://en.wikipedia.org/wiki/Context-sensitive_half-life

Half Life is the 2006 debut novel of American writer and artist Shelley Jackson. The novel presupposes an alternate history in ... Half Life received mixed-to-positive reviews; Newsweek called it "brilliant and funny," and The New York Times, while praising ...

https://en.wikipedia.org/wiki/Half_Life_(Jackson_novel)

Two weeks after the initial release of Half-Life 2, Valve revealed and released Half-Life 2: Deathmatch on Steam. Deathmatch ... like Half-Life's multiplayer, does not develop any part of the plot or story of the Half-Life series. Deathmatch includes some ... "Half-Life 2 Deathmatch Official?". IGN. Archived from the original on March 24, 2014. Retrieved March 24, 2014. "Half-Life 2: ... which allowed NVIDIA graphics card users to download and play Half-Life 2: Deathmatch along with Portal: First Slice, Half-Life ...

https://en.wikipedia.org/wiki/Half-Life_2:_Deathmatch

Between Half-Life 2: Episode Two (2007) and Half-Life: Alyx (2020), Valve canceled at least five Half-Life games, including ... Half-Life is a series of first-person shooter games developed and published by Valve, beginning with the original Half-Life, ... was developing a Half-Life expansion pack to follow Half-Life: Opposing Force. 2015, Inc declined to comment. On March 18, 2000 ... "Beta Half-Life for Sega Dreamcast". nextdimension. Retrieved July 28, 2013. "Half-Life 2: Episode One gold, Two dated, Three ...

https://en.wikipedia.org/wiki/Unreleased_Half-Life_games

... reforming influence on the spiritual life of the time in the Benedictine monasteries of Germany during the second half of the ... fifteenth, and the first half of the sixteenth, century. At the death of Abbot John of Hagen thirty-six monasteries had already ...

https://en.wikipedia.org/wiki/Bursfelde_Abbey

About half of Scotland's population live within an hour's travel time of Stirling. Local bus services to districts within the ... "Student sport - Student life - University of Stirling". University of Stirling. Archived from the original on 23 November 2016 ... Morris, David B. (1919). The Stirling merchant gild and life of John Cowane. Stirling: Morris, David B. pp. 195-210. Retrieved ... Morris, David B. (1919). The Stirling merchant gild and life of John Cowane. Stirling: Morris, David B. pp. 202-204. Retrieved ...

https://en.wikipedia.org/wiki/Stirling

... the half-goat/half-man creature celebrated in the annual ritual, was published by Capra Press in Santa Barbara. From 1980 ... Ranaldo, Lee (August 1996). "Into The Mystic". The Wire Strauss, Neil (October 12, 1995). "The Pop Life: To Save Jajouka, How ...

https://en.wikipedia.org/wiki/Mohamed_Hamri

... accounts for about half of worldwide edible oil production. Spearmint oil - often used in flavoring mouthwash and chewing gum, ... thus guaranteeing shelf life. Preservatives Preservatives prevent or inhibit spoilage of food due to fungi, bacteria and other ...

https://en.wikipedia.org/wiki/List_of_food_additives

He was sentenced to life in prison without the possibility of parole. 2008 - Lateisha "Tiesh" Green was shot and killed on 14 ... "Convicted Killer Walks Away From Half-way House , Vancouver Sun". 13 September 2009. Retrieved 20 November 2019. A Direcção e o ... Vallum was convicted of both state murder charges, for which he received life imprisonment without parole, and federal charges ... "Transgender Day of Remembrance honors lives lost while marking staggering milestone". "Fatal Violence Against the Transgender ...

https://en.wikipedia.org/wiki/List_of_people_killed_for_being_transgender

"You only had to walk out your door to join the fun"-Mike Lafavore The media's coverage of hippie life in the Haight-Ashbury ... the pass-around readership of which is thought to have exceeded a half-million people that summer, and the Berkeley Barb. The ... Eddi Fiegel (2006). Dream a Little Dream of Me: The Life of 'Mama' Cass Elliot. pp. 225-226. ISBN 9780330487511. Retrieved ... ISBN 0-394-62081-X. IDBN 0-394-55013-7. Engebråten, Linda (2010). "1967 : a year in the life of The Beatles : history, ...

https://en.wikipedia.org/wiki/Summer_of_Love

A Life in Letters, Penguin Books, 2004, ISBN 978-0-14-044922-8 Bartlett, Rosamund, Chekhov: Scenes from a Life, Free Press, ... The letters Chekhov wrote during the two-and-a-half-month journey to Sakhalin are considered to be among his best. His remarks ... In the last decades of his life he became an atheist. In March 1897, Chekhov suffered a major haemorrhage of the lungs while on ... "For the first time in literature the fluidity and randomness of life was made the form of the fiction. Before Chekhov, the ...

https://en.wikipedia.org/wiki/Anton_Chekhov

Her home's religious circumstances were also quite unique since half were Roman Catholic and the other half was Protestant ( ... The Positio was presented to Rome for further evaluation in 2011 and Pope Francis recognized that she had lived a life of ... "Colours of Fire: The Life of Hanna Chrzanowska". The Am-Pol Eagle. Retrieved 19 July 2017. "Venerable Hanna Helena Chrzanowska ... 1998 until January 2003 and it saw the accumulation of documents and witness testimonies in order to collate work on her life ...

https://en.wikipedia.org/wiki/Hanna_Helena_Chrzanowska

He is very forgetful, often forgetting that he lives in the studio, that he is on a television show, or that the fans in the " ... The popularity of the clips led to MTV America offering a half-hour format called The Sifl & Olly Show in July 1998. The show ... As such, his show generally devolves within seconds to him crying about his current situation in life, (specifically "I DON'T ...

https://en.wikipedia.org/wiki/The_Sifl_and_Olly_Show

While the tool worked, Pittsburgh compound B relies on the use of carbon-11, a radioactive isotope with a half-life of 20 ... Once they found a candidate dye, they attached the positron-emitting fluorine-18, a radioactive isotope with a half-life of ...

https://en.wikipedia.org/wiki/Avid_Radiopharmaceuticals

He was inducted into the Texas Rodeo Cowboy Hall of Fame in 1998, which he described as one of the highlights of his life. ... He said that year, "handling animals, even the bulls, isn't half as tough as playing football ... I've never gotten hurt in a ...

https://en.wikipedia.org/wiki/Johnny_Hatley

It is native to south eastern Australia and lives for 15 years on average. This wattle species is tolerant of drought and frost ... with a clavate aril that can be half as long as the seed. The species was first formally described by the botanist John Lindley ...

https://en.wikipedia.org/wiki/Acacia_acinacea

In the latter part of his life-possibly about 1596, when he published his Wits Miserie and the World's Madnesse, which is dated ... Anne Lodge (born 1558-1562, buried 19 December 1573). Lodge's half-sister, Sara, married the printer Edward White. Thomas ... Lodge seems to have married his first wife Joan in or before 1583, when, "impressed with the uncertainty of human life", he ... His second historical romance, the Life and Death of William Longbeard (1593), was more successful than the first. Lodge also ...

https://en.wikipedia.org/wiki/Thomas_Lodge

... is a collaborative album by musicians Jad Fair (of the band Half Japanese) and Daniel Johnston. It was first ... That track was eventually released on Tucker's second studio album, Life in Exile After Abdication. "Some Things Last a Long ... "A Q&A with Jad Fair of Half Japanese". San Antonio Current. Retrieved 2021-10-30. "Jad Fair: It's Spooky". Pitchfork. Retrieved ... Texas with Half Japanese. Three years later, in April 1988, Johnston was in New York City recording at Noise New York Studios, ...

https://en.wikipedia.org/wiki/It's_Spooky

The aim is to get young people's contribution towards the formulation of policies relevant to young peoples lives." The ... which the Sicilian poets Sophron and Epicharmus had cultivated half a century earlier. These works, admired and imitated by ... Laouris, Yiannis (16 November 2014). "Reengineering and Reinventing both Democracy and the Concept of Life in the Digital Era ...

https://en.wikipedia.org/wiki/Dialogue

... where she lives out the rest of her life. April 30 - Hildegard, wife of King Charlemagne, dies in childbirth after her ninth ... April 30 - Emperor Kōnin of Japan abdicates the throne after an 11-year reign, in favour of his half-Korean son, Kanmu. July 31 ... He succeeds in wiping out more than half of the occupying Frankish forces and again raises the banner of revolt. Autumn - ...

https://en.wikipedia.org/wiki/780s

Often such works, especially if in a horizontal format and at half-length or with seated figures, were painted for the homes of ... "Titian's Life and Times", in Jaffé, David (ed), Titian, The National Gallery Company/Yale, London 2003, ISBN 1 857099036 "NG": ... and at half-length. Most accounts of the development restrict themselves to Italy, ignoring northern parallels, despite the ...

https://en.wikipedia.org/wiki/Sacra_conversazione

"/"Should I Stay or Should I Go" four-and-a-half stars out of five. Despite "Should I Stay or Should I Go" having received more ... " "reaffirm[s] that there is still life in The Clash." This song was featured in the 2000 comedy film, Kevin & Perry Go Large ...

https://en.wikipedia.org/wiki/Straight_to_Hell_(The_Clash_song)

And there are some songs on it that were totally new, so the album consists of three phases in my life. - Doja Cat on the ... Ranking it among their favorite albums of the first half of 2018, NPR described Amala as a "13-track collection of bubbly, hip- ... I'm So Pumped For My Life Right Now'". Billboard. Retrieved November 6, 2020. A lot of people liked Amala, and that's great. ...

https://en.wikipedia.org/wiki/Amala_(album)

... however almost half of the population have it, though only a few of them will develop AVNRT at some point in life. Cystic ...

https://en.wikipedia.org/wiki/Atrioventricular_node

Benji, a stray dog who lives in an abandoned house on the outskirts of a small town, sets about his daily ritual of visiting ... Gene Siskel gave the film two-and-a-half stars out of four, calling it "agreeable" but criticizing "a few cheap grabs for ... Section 3, p. 7. Gross, Linda (November 19, 1974). "Look at Life From a Dog's Point of View". Los Angeles Times. Part IV, p. 9 ... Siskel, Gene (June 19, 1975). "'Benji' presents life at ground level". Chicago Tribune. ...

https://en.wikipedia.org/wiki/Benji_(1974_film)

The Beautiful Life' will get second life online; ill-fated CW show headed for the Web". Daily News. Retrieved March 13, 2010. " ... Two and a Half Men - Renewed for three additional seasons in March 2009, running through its ninth season in 2011/12. ... Life Unexpected - Renewed for a second season on May 18, 2010. One Tree Hill - Renewed for an eighth season on May 18, 2010. ... The Beautiful Life: TBL - Canceled on September 25, 2009, after two low rated episodes. This is the first cancellation of the ...

https://en.wikipedia.org/wiki/2009–10_United_States_network_television_schedule

The half-acre (2,000 m2) lot slopes up slightly toward the west. In addition to the house, on the eastern end, a garage is ... ". "1936 Prototype House Gets a New Life". The New York Times. February 9, 1992. Retrieved February 4, 2012. (Articles using ... yet solid enough that none had begun to deteriorate when the house was renovated half a century later. Gelbman's workers ... and thus more affordable in the Depression economy where traditional homes were too expensive for more than half the population ...

https://en.wikipedia.org/wiki/Hastings_Prototype_House

The genus Phyllanthus, one of the largest genera of flowering plants with over 1200 species, has more than half of the species ... "Malpighiales phylogenetics: Gaining ground on one of the most recalcitrant clades in the angiosperm tree of life." American ... Gaining ground on one of the most recalcitrant clades in the angiosperm tree of life". Am. J. Bot. 96 (8): 1551-70. doi:10.3732 ...

https://en.wikipedia.org/wiki/Phyllanthaceae

Each question was debated for two and a half hours a night for nine nights. Among the participants: Eleven had been born and ... They were subject to discriminatory treatment in everyday life. The original "remedy" for this problem was to help them go " ... Tappan, Lewis (1870). The Life of Arthur Tappan. New York: Hurd and Houghton. Weld, Theodore D. (April 12, 1834). "Letter to ... with a stick two feet and a half long, and nearly as thick as my wrist ; striking her over the head, and across the small of ...

https://en.wikipedia.org/wiki/Lane_Seminary

serial killer Walter Ellis sentenced to life in slayings of 7 women". CBS News. Archived from the original on May 16, 2021. ... but was only sentenced to five and a half years of probation. Over the next few months, however, he committed several ... turning towards a life of crime. At the age of 14, Ellis was arrested for the first time under the charges of robbery and ... receiving seven consecutive life sentences without the chance of parole. Walter E. Ellis was born on June 24, 1960, in Holmes ...

https://en.wikipedia.org/wiki/Walter_E._Ellis

Sixteen half-hour episodes aired in the first season, followed by a two-hour finale drawing connections between the sixteen ... Media Life Magazine "'Big History,' bad facts and much BS". Archived from the original on May 28, 2017. Retrieved September 16 ... The series has been criticized by Media Life Magazine for its factual inaccuracies. The series takes its title from a coinage ...

https://en.wikipedia.org/wiki/Big_History_(TV_series)

When playing against the Western Samoa Golden Oldies team, Meninga started on the bench for the first time in his life and ... The tradition of the three 'halves' has continued on. The early games also established other rules of Veterans Rugby, like no ...

https://en.wikipedia.org/wiki/ACT_Veterans_Rugby_Club

He also played a part in religious life, issuing an edict in 380 that established the faith of the bishops of Rome and ... The flourishing of Lydia during the first half of the 6th century BC is also dubbed the Lydian Empire period. Although the ... However, he devoted the rest of his life to military conquests further east, dying in 323 BC. Thus he fulfilled his father's ... Paul came originally from Tarsus in Cilicia, but spent much of his early life in Jerusalem. Early accounts suggest a community ...

https://en.wikipedia.org/wiki/Classical_Anatolia

The western half of the city occupies the numerous commercial, industrial, and business establishments, while the other is ... They were convicted and sentenced to life imprisonment in 2013. Jose Catindig Jr., who served as vice mayor, became mayor to ...

https://en.wikipedia.org/wiki/Santa_Rosa,_Laguna

... www.half-life2.comWhats hot: Quite possibly the best game of 2004, Half-Life 2 offers non-stop action, ... ... Not so hot: No multiplayer in Half-Life 2 itself, though with a few command-line hacks you can enable that. Counter-Strike ... Whats hot: Quite possibly the best game of 2004, Half-Life 2 offers non-stop action, gorgeous environments, and more fun than ... If these three things still haunt your dreams from when Half-Life came out way back in 1998, then its time to return to that ...

https://www.extremetech.com/extreme/73906-font-color339933-size1halflife-2

The half-life of a substance undergoing decay is the time it takes for the amount of the substance to decrease by half. It was ... 6 days/2 days = 3 half lives 100/2 = 50 (1 half life) 50/2 = 25 (2 half lives) 25/2 = 12.5 (3 half lives) So 12.5g of the ... Then, you can use any half-life calculator online to determine the half-life.[14] X Research source *If you know the half-life ... Calculate-Half-Life-Step-8.jpg\/v4-460px-Calculate-Half-Life-Step-8.jpg","bigUrl":"\/images\/thumb\/c\/ca\/Calculate-Half-Life- ...

https://www.wikihow.com/Calculate-Half-Life

An email will not be created automatically. The email will only be created once you click on the "Send Email" button.. ...

https://www.startrek.com/watch_video/episode-preview-half-a-life

As a result, Half-Life 2 is still the same Half-Life on steroids. All obvious flaws were carefully removed from it. Besides, ... And Half-Life 2 deceived us all right. 12 hours of shooting for truth ended in a poorly disguised promise of a sequel. Its a ... Half-Life 2 is full of such shifts. For example, when the endless buggy ride starts getting on your nerves, you come across a ... Everyone will play Half-Life 2 no matter what well write about it. And most probably the majority will like it. For this ...

http://ixbtlabs.com/articles2/halflife2/index.html

More than half of the very old now live without a spouse, and we have fewer children than ever beforeyet we give virtually no ...

https://www.theatlantic.com/daily-dish/archive/2010/07/how-the-older-half-lives/184182/

I played the final three hours of Half-Life: Alyx in a single session. Before Alyx, I never used VR for more than 30 minutes at ... of Half-Life 1 and Half-Life 2 the repercussions of its story extend well into whatever future there is for the Half-Life ... Half-Life: Alyx review. Valve has created both a great VR game, and another great Half-Life game. By Christopher Livingston ... What Half-Life: Alyx lacks in close-up interactions it makes up for in the sheer thrill of being in a fresh Half-Life game ...

https://www.pcgamer.com/half-life-alyx-review/?utm_content=bufferef033&utm_medium=social&utm_source=facebook&utm_campaign=buffer_pcgamerfb&fbclid=IwAR2TkUWVQALs_-X_W7kAcshsrdO-f3fC4KxzgCc4vpKIVOXRX43uVJgpUqc

Frister nok en gang med Half-Life 3, men hva er poenget?. ...

https://itavisen.no/tag/half-life-3/?filtered=latest

Its easy misinterpret half-life to mean "one half of the time it takes for whatever atoms youre looking at to decay," but it ... the half-life] is always the same.". The whole life of the material, on the other hand, would be equal to the lifespan of the ... "Why do scientists measure things like radioactive elements in half-life? Why not just measure the whole life?" ... Half-life steps onto the scene in the decay process. While the lifespan of any individual atom is random and unpredictable, the ...

https://www.mentalfloss.com/article/30742/why-do-scientists-measure-things-half-life

... Read customer reviews, and links to write your own review (Page 1 of 1). ... Literate persons who do not read half a life, will die having had half a life, pardon the pun. When I need to be revitalised, I ... What readers think of Half A Life, plus links to write your own review.. Summary , Excerpt , Reading Guide , Reviews , ... Biswas, now I can be totally revitalised for the next few years having read half a life, its brilliant! ...

https://www.bookbrowse.com/reader_reviews/index.cfm/book_number/929/half-a-life

Half-Life www.xprojectmanagement.com/uncategorized/half-li... - Details. project_management: Article by x-Project Management ...

https://folkd.com/detail/www.xprojectmanagement.com%2Funcategorized%2Fhalf-life

... 05:34. *Share this - ... Howard Stern: The most remarkable two-and-a-half hours of my life. 05:34 ... New book digs into the life and legacy of Charles Barkley. 08:19 ... Targeted comments against LGBTQ community have real-life ...

https://www.msnbc.com/morning-joe/watch/howard-stern-the-most-remarkable-two-and-a-half-hours-of-my-life-155068997612

LIFE keyboard_arrow_right Behavior/Psychology Cognition and Learning Education Featured: LifeWire Gay Rights Government/Law ... Latest News Currently Embargoed News Journal News Medical News Science News Life News Business News Expert Pitch Google Fact ... Latest News Coronavirus News Currently Embargoed News Research News Releases Journal News Medical News Science News Life News ... Understanding how to make patients feel more comfortable with clinicians is key to helping patients address such life- ...

https://www.newswise.com/articles/up-to-half-of-patients-withhold-life-threatening-issues-from-doctors

It is essentially the period of time that it takes for the concentration of the amount of the drug to be reduced by half, and ... A drugs half-life indicates how long a substance will remain active in the body. ... Please can you give a brief introduction to the half-life of drugs?. A drugs half-life indicates how long a substance will ... What are the main challenges in extending the half-life of drugs?. The main challenge in extending the half-life of drugs is ...

https://www.news-medical.net/news/20140527/Half-life-extension-technology-an-interview-with-Dermot-Pearson-Novozymes-Biopharma.aspx

... multiplayer Half-Life 2 modification, centered around a zombie-apocalypse, which throws all but one player in the shoes of ... Scrap meat is a single & multiplayer Half-Life 2 modification, centered around a zombie-apocalypse, which throws all but one ... Half-LifeLover Dec 18 2014. Faster finish it. Cant wait to play ...

https://www.moddb.com/mods/scrap-meat

Half-Life Deathmatch: Source Rating Breakdown. 6836 half-life-deathmatch-source This is a breakdown of ratings by CrossOver ... Half-Life Deathmatch: Source is a recreation of the first multiplayer game set in the Half-Life universe. Features all the ... How to Install CrossOver to run Half-Life Deathmatch: Source. Click the Download Free Trial button above and get a 14-day, ... Half-Life Deathmatch: Source Advocates. The following is a list of BetterTesters who Advocate for this application. Do you want ...

https://www.codeweavers.com/compatibility/crossover/half-life-deathmatch-source

I have lived over half of my life.. Hey ho, the midlife crisis. Its a Jeremy Clarkson state of mind. I always imagine Clarkson ... Midlife or not, in the end, or in the middle, these are the days of my life. These are the days of your life. And the thing to ... It makes life pass so quickly, and that makes me panic.. I dont want to wake up in 10 years time, when Im 54, and feel the ... It takes time to get your head around the fact that you cant spend your life as you used to, that you cant go out and party ...

https://www.theguardian.com/society/2011/aug/14/miranda-sawyer-midlife-crisis-mortality

Freeman-free VR prequel Half-Life: Alyx finally arrives on Steam on March 23rd, a mere 13 years after HL2: Episode 2s decade- ... A new Half-Life game is launching in a little over a month. Huh, all sounds very real when you put it like that. Its only been ... Honestly, learning Half-Life: Alyx was a VR exclusive took the wind out of my sails. It does sound proper brilliant, though. ... Like Matt, small details like being able to put a bucket on a headcrab and watch it panic helped crystalise what Half-Life in ...

https://www.rockpapershotgun.com/half-life-alyx-is-bringing-us-back-to-city-17-in-six-weeks

The half-life of knowledge or half-life of facts is the amount of time that has to elapse before half of the knowledge or facts ... These ideas of half-life applied to different fields differ from the concept of half-life in physics in that there is no ... An engineering degree went from having a half life of 35 years in ca. 1930 to about 10 years in 1960.[1] ... A Delphi Poll showed that the half life of psychology as measured in 2016 ranged from 3.3 to 19 years depending on the ...

https://www.wikiwand.com/en/Half-life_of_knowledge

The Trick That Cuts Cleaning Time In Half ... Life. Style & BeautyFood & DrinkParentingTravelWellness ... NEWSPOLITICSENTERTAINMENTLIFEVOICESHUFFPOST PERSONALELECTIONSNEWSLETTERS. About UsAdvertiseContact UsRSSFAQCareersArchiveUser ... An essential daily guide to achieving the good life. Subscribe to our lifestyle email. ... This Splurge Will Impress The Skin Care Fanatic In Your Life The Most. ...

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Man Makes Real Life Buster Sword, Promptly Chops Table in Half. Stubby the Rocket Thu Oct 10, 2013 10:40am 5 comments Favorite ... Rug ged internet blacksmith show Man At Arms is no stranger to forging in real life what we could previously only play with ... And a 90 degree downslash is all it takes for the real Buster Sword to cleave a table in half. ...

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Hydroxychloroquine has a half life of 22 days. hydroxychloroquine sulfate half life Terminal half-life= 40-50 days. malariae, P ... In the same study, the plasma peak concentration was 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 …. Half-life (T ... half-life was approximately 3 to 4 hours and the terminal half-life ranged from 40 to 50 days. Chloroquine is also occasionally ... Hydroxychloroquine sulfate half life. Learn about the wide-ranging effects of hydroxychloroquine (Plaquenil®) in the treatment ...

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Examples of biological half-lives. Water. The biological half-life of water in a human is about 7 to 10 days. It can be altered ... The biological half-life of a substance is the time it takes for a substance (drug, radioactive nuclide, or other) to lose half ... Biological half-life is an important pharmacokinetic parameter and is usually denoted by the abbreviation t1/2.[1] ... The biological half-life of caesium in humans is between one and four months. This can be shortened by feeding the person ...

https://www.wikidoc.org/index.php/Biological_half-life

Charlie Baker signs a much-anticipated life sciences bill. ... Baker Signs Bill Allotting Nearly Half A Billion To Mass. Life ... Over the course of five years, Massachusetts will dole out roughly half a billion dollars to support the life sciences. ... Life Sciences Center Anticipates $500 Million State Investment. Justin Kaplan CommonHealth Fellow. Justin Kaplan is a summer ... Describing the occasion as "a very big day for the life sciences community," Gov. Charlie Baker on Friday signed into law the ...

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How More Education Could Save A Half-Million American Lives : NPR Ed A new study finds strong links between staying in school ... One is to encourage education policy folks to talk about education as a matter of life-and-death importance. If, that is, we ... As society becomes more unequal in so many other ways, life expectancy, too, is diverging. ...

https://www.npr.org/sections/ed/2015/07/08/420838501/how-more-education-could-save-a-half-million-american-lives

To the rest of America, this wasnt even a known problem until in 1890; Jacob Riis published "How the Other Half Lives", ... So, they tried to shut out the immigrants, until an immigrant himself Jacob Riis, published "How The Other Half Lives". This ... Jacob Riiss How The Other Half Life. 1399 Words , 6 Pages. The dramatic economic expansion that American experienced during ... More about How The Other Half Lives Summary. *. American Immigration From 1900 To 1910. 221 Words , 1 Pages ...

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The outcome of the great Half-Life Alyx left us wanting even more for... ... About 7 minutes to enjoy the action of this new campaign created by Half Life fans. ... About 7 minutes to enjoy the action of this new campaign created by Half Life fans.. The outcome of the great Half-Life Alyx ... Steam Workshop: Half-Life: Alyx. [b]LEVITATION[/b] is a community campaign featuring: [list] [*]New story (3-4 hours in length ...

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Thats the way life is. Only we forget that life isnt endless. Life puts on the gas, speeds towards the edge of a cliff. We ... No one can really be ignorant about youth, any more than we can be ignorant about a job weve held for most of our lives. This ... Keiner argues that to human beings, the first 18 years of life seem just as long as the remaining 70. Until we reach the end, ... We spend our whole adult lives trying to get away from this powerlessness, to find control. Many of us dont succeed. We can ...

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The first new Half-Life game in more than a decade is coming next March, and you can get some exclusive bonus content for it if ... Half-Life: Alyx Has Valve Index-Exclusive Content If You Buy The VR Headset This Year. You can get some extra Half-Life: Alyx ... Half-Life: Alyx arrives 13 years after the series last release, 2007s Half-Life 2: Episode 2, which ended on a cliffhanger. ... You can read everything we know about Half-Life: Alyx so far in our roundup, and you can check out the first Half-Life: Alyx ...

https://www.gamespot.com/articles/half-life-alyx-has-valve-index-exclusive-content-i/1100-6471632/

IGN spoke with Half-Life: Alyx programmer Robin Walker before the reveal of Valve's new Half-Life project, which is slated to release on all PC-based VR headsets in March 2020. (ign.com)
Mar 31, 2020 · Hydroxychloroquine has a half life of 22 days. (musicaenlamochila.net)
The game is expected to launch on Steam in March 2020 and will be a "full-length" VR-only adventure set between the events of the original title and Half-Life 2 . (gamespot.com)
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Life expectancy at birth in the United States declined by 1.5 years from 2019 to 2020 to the lowest level since 2003, according to new provisional data pdf icon from the CDC's National Center for Health Statistics (NCHS). (cdc.gov)
The drop in life expectancy in 2020 was the largest one-year decline since World War II, when life expectancy declined 2.9 years between 1942 and 1943. (cdc.gov)
The data are featured in a new report, " Provisional Life Expectancy Estimates for 2020 pdf icon ," showing life expectancy at birth for the total population declined from 78.8 years in 2019 to 77.3 years in 2020. (cdc.gov)
The report also shows the disparity in life expectancy between men and women grew in 2020 from 5.1 years in 2019 to 5.7 years in 2020. (cdc.gov)
The decline in life expectancy between 2019 and 2020 can primarily be attributed to deaths from the pandemic, as COVID-19 deaths contributed to nearly three-fourths or 74% of the decline. (cdc.gov)
Though U.S. Hispanics have longer life expectancy than non-Hispanic blacks or whites, they had the largest decline in life expectancy of these groups during 2020, a three-year drop from 81.8 years in 2019 to 78.8 years in 2020. (cdc.gov)
Hispanic males had the largest decline in life expectancy in 2020 with a drop of 3.7 years. (cdc.gov)
The disparity in life expectancy between the Hispanic population and the non-Hispanic white population closed significantly, from 3 years in 2019 to 1.2 years in 2020. (cdc.gov)
The gap in life expectancy between the Hispanic population and the non-Hispanic black population barely changed between 2019 and 2020 - from 7.1 years in 2019 to 7 years in 2020. (cdc.gov)
Life expectancy for the non-Hispanic black population declined 2.9 years from 74.7 years in 2019 to 71.8 in 2020 - the lowest life expectancy for this population since 2000. (cdc.gov)
Life expectancy for the non-Hispanic white population declined 1.2 years from 78.8 years in 2019 to 77.6 years in 2020 - the lowest life expectancy for this population since 2002. (cdc.gov)
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Half-Life Deathmatch: Source is a recreation of the first multiplayer game set in the Half-Life universe. (codeweavers.com)
Half-Life 1 Anthology obsahuje: Half-Life (Game of the Year Edition), Half-Life: Opposing Force, Half-Life: Blue Shift, Half-Life: Deathmatch a Team Fortress Classic. (abcgames.sk)

Valve's return to Half-Life, only in VR. (pcgamer.com)
IGN was able to ask a few questions about Valve's new VR project for the official reveal and learned several new details, including Half-Life: Alyx's length, and how the project began. (ign.com)
You can get some extra Half-Life: Alyx bonuses if you pick up Valve's VR headset in 2019. (gamespot.com)
Straight from Valve's Half-Life video game series comes the headcrab plush. (necaonline.com)

Five years before the events of Half-Life 2, Alyx Vance is performing surveillance and recon in the Combine-controlled City 17. (pcgamer.com)
The newly released Half-Life: Alyx is set five years before Half-Life 2 and stars Gordon's ally Alyx Vance, so it doesn't majorly advance the story. (theverge.com)
The outcome of the great Half-Life Alyx left us wanting even more for Half Life 3, of course, but also to learn more about Alyx Vance and the challenges that lay ahead. (neogaf.com)

After winning a key military victory, Gordon and Alyx are preparing to hunt down a long-lost research ship called the Borealis, and Eli has hinted at some new information about the mysterious G-Man, who placed Gordon in stasis and saved Alyx's life as a child. (theverge.com)

The biological half-life of caesium in humans is between one and four months. (wikidoc.org)

You can calculate the half-life of any substance, given the rate of decay, which is the initial quantity of the substance and the quantity remaining after a measured period of time. (wikihow.com)
Therefore, you can calculate the half-life for a particular element and know for certain how quickly it will break down no matter what. (wikihow.com)
Read on to discover the half-life of a drug and how to calculate the half-life of a medication. (omnicalculator.com)

While Half-Life: Alyx is playable on all Steam-compatible VR headsets, you can get the game for free if you own Valve Index, and it'll also come with some additional content--provided you buy one in time. (gamespot.com)
You'll also be able to explore environments from the game in your SteamVR Home space, and there will be "special" content themed after Half-Life: Alyx in Counter-Strike: Global Offensive . (gamespot.com)

Valve has created both a great VR game, and another great Half-Life game. (pcgamer.com)
I didn't have much doubt Half-Life: Alyx would be a great VR experience-Valve makes its own VR headset and software, after all. (pcgamer.com)
Today, Valve revealed that Freeman-free VR prequel Half-Life: Alyx has nailed down a March 23rd release date. (rockpapershotgun.com)
Valve has officially revealed Half-Life: Alyx , a full-length VR entry into the Half-Life series. (ign.com)
Valve has been heavily invested in VR technology for years, and Valve is confident enough in the tech to create a full-length Half-Life game for the platform. (ign.com)
According to Valve, it's the length of Half-Life 2, which most estimates clock in at around 13 to 15 hours. (ign.com)
Even though Half-Life: Alyx is looking to be a full-length adventure, Valve was initially just testing VR technology. (ign.com)
Half-Life: Alyx has been built by veterans of previous Half-Life games, other developers who are new to the IP, and even some who are new to Valve. (ign.com)
Otherwise, let's talk about what Alyx means for the Half-Life universe - where Valve says it's not done making games . (theverge.com)
For now, Valve has not confirmed either one project or the other, so we have to pull in fans to liven up the wait in the best possible way, and here comes this promising Half-Life Alyx: Levitation. (neogaf.com)
It's been a long time coming, but Valve finally unveiled a new installment in its seminal Half-Life series, titled Half-Life: Alyx . (gamespot.com)
You can read more about the Valve Index bonuses on the official Half-Life website . (gamespot.com)
As previously mentioned, you'll also get Half-Life: Alyx for free if you own Valve Index. (gamespot.com)
Valve may be trying to keep everything a secret, but the puzzle is now starting to form with Half Life 3 possibly becoming one of the first releases for the Steam Machines in 2014. (product-reviews.net)
Getting straight to the point, Valve has now officially trademarked Half Life 3 in Europe. (product-reviews.net)
As the internet social media boards now go into overdrive, it's worth bearing in mind that the Half Life 3 trademark has occurred almost instantly after Valve wrapped up their announcements regarding Steam Machines, the exciting Linux-based SteamOS and of course the haptics-fueled Steam controllers. (product-reviews.net)
Imagine if Valve take to the stage in 2014 at a private event and announce that Half Life 3 is going to be the first game to run on SteamOS and Steam Machines - with the added bonus of living room support as well as the regular PC crowd. (product-reviews.net)

Veltis is an albumin-based half-life extension technology for proteins and peptides that enables drug developers to define how long their drug candidate is therapeutically active in the body, and, as a result, enables dosage size and frequency to be tailored to offer improved therapeutic impact. (news-medical.net)
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Half-life (T ½): In a bioavailability study of 5 healthy participants receiving 1 oral and 1 intravenous (IV) dose of hydroxychloroquine sulfate 200 mg (155 mg base) administered on separate occasions, the mean terminal elimination half-life of hydroxychloroquine, as calculated from blood data, was more than 40 days for both the oral and IV doses. (musicaenlamochila.net)
The half-life of a drug describes the process of its elimination . (omnicalculator.com)
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). (e-lactancia.org)

This gap in life expectancy had been narrowing over the past three decades, from 7.1 years in 1993 to 4.1 in 2019. (cdc.gov)

Quite possibly the best game of 2004, Half-Life 2 offers non-stop action, gorgeous environments, and more fun than you can beat down with a crowbar. (extremetech.com)
The game has been licked all over, bitten, and X-rayed so often for the year and a half since the NDA was lifted, that after its long awaited (to say the least! (ixbtlabs.com)
The game process of the first Half-Life migrated to the second part practically unchanged. (ixbtlabs.com)
But I was skeptical it could also be a great, proper Half-Life game, and I was thrilled to discover it really is. (pcgamer.com)
A new Half-Life game is launching in a little over a month. (rockpapershotgun.com)
Not in the game, mind, but in some Steam VR Home environments themed in Half-Life's oppressive city. (rockpapershotgun.com)
If, somehow, March 23rd is still too far away, you could always go bash through every other Half-Life game for free - at least, 'til Alyx hits Steam next month. (rockpapershotgun.com)
There weren't even plans to make a Half-Life game in VR. (ign.com)
We didn't set out to make a Half-Life game," Walker revealed. (ign.com)
Unfortunately, momentum retention through portals is a requirement for most of the latter half of Portal's gameplay, and we didn't think we could build a VR game that required that movement of its players (yet). (ign.com)
One of the things that excites us about our game is that we've been able to use that combination of past experience and fresh perspective to build something that feels like Half-Life, but doesn't feel dated. (ign.com)
Gordon last appeared in Half-Life 2: Episode Two , an extension of the 2004 game Half-Life 2 . (theverge.com)
When I spoke to level designer Corey Peters before the game's release, he said Alyx was supposed to use one for puzzles and combat because "it's a Half-Life game - it has to have a crowbar in it. (theverge.com)
We've seen comments on how Half Life 3 is now 'overrated and overhyped' , but do you think that the game is still one of the most anticipated of all time? (product-reviews.net)
Now, WayForward has bundled everything together in Shantae: Half-Genie Hero - Ultimate Edition , the 'complete' version of the game. (nintendolife.com)

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No multiplayer in Half-Life 2 itself, though with a few command-line hacks you can enable that. (extremetech.com)

This is in contrast to salicylates (eg, aspirin), which irreversibly bind to COX and inhibit production for the entire life of the cell, or acetaminophen, which inhibits COX centrally. (medscape.com)

Does temperature or concentration affect the half-life? (wikihow.com)
While chemical changes are sometimes affected by their environment or concentration, each radioactive isotope has its own unique half-life that isn't affected by these changes. (wikihow.com)
It is essentially the period of time that it takes for the concentration of the amount of the drug to be reduced by half, and therefore, determines how frequently a drug needs to be administered to maintain its therapeutic effect. (news-medical.net)
There are circumstances where the half-life varies with the concentration of the drug. (wikidoc.org)
In pharmacology, when we talk about the half-life of a drug, we usually mean the time it takes a drug's concentration in the blood plasma to reduce by half . (omnicalculator.com)
Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone. (cdc.gov)

Hemorrhagic and thrombotic adverse events associated with emicizumab and extended half-life factor VIII replacement drugs: EudraVigilance data of 2021. (bvsalud.org)

A drug's half-life indicates how long a substance will remain active in the body. (news-medical.net)

Why do scientists measure things like radioactive elements in half-life? (mentalfloss.com)
The measurement is useful in radiometric dating, says Dee, because exponential decay means "it doesn't matter how much radioactive material you have, the time taken until half of it is gone [the half-life] is always the same. (mentalfloss.com)
The biological half-life of a substance is the time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity, as per the MeSH definition. (wikidoc.org)
This form of half-life is not to be mistaken with the decay of radioactive elements! (omnicalculator.com)
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Amiodarone finds its place amongst the drugs with the longest half-life. (omnicalculator.com)

If these three things still haunt your dreams from when Half-Life came out way back in 1998, then it's time to return to that world and dive headlong into the next installment of the Gordon Freeman Chronicles. (extremetech.com)
The half-life of a substance undergoing decay is the time it takes for the amount of the substance to decrease by half. (wikihow.com)
The term "half-life" refers to the amount of time that half of the starting substance takes to decay or change. (wikihow.com)
It's easy misinterpret half-life to mean "one half of the time it takes for whatever atoms you're looking at to decay," but it actually means "the length of time it takes for one half of the atoms you're looking at to decay. (mentalfloss.com)
The industry is increasingly requiring more advanced technologies that enable greater control over the half-life of drug candidates and allow developers to tailor the period of time a drug remains active to meet the specific needs of individual medical conditions. (news-medical.net)
The half-life of knowledge or half-life of facts is the amount of time that has to elapse before half of the knowledge or facts in a particular area is superseded or shown to be untrue. (wikiwand.com)
It's been designed to take into account that doing things in real life actually take time and energy so it's a much slower pace than an fps where you can turn 360 degrees in an instant and move around at break neck speeds for hours without tiring. (neogaf.com)
After a few months of silence, it's now time to start talking about Half Life 3 again. (product-reviews.net)
The half time of a given drug - this input can be either in minutes, hours, or days. (omnicalculator.com)
The half-life of a drug describes the amount of time it will take half of the administered drug to be eliminated. (omnicalculator.com)
The half-life of a drug helps us assess the potency and toxicity of a drug over a given amount of time. (omnicalculator.com)
The half-life of a drug is the complete opposite of its doubling time. (omnicalculator.com)
That means almost half of Americans aren't taking time off to get away from things and relax. (bestlifeonline.com)
While bigger purchases may be impossible at the moment, Daramus advises everyone to take the time to enjoy the smaller things in life , whether it's a picnic with your family or a free art exhibition in your town. (bestlifeonline.com)
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I tell him all the time that he saved my life. (georgetakei.com)
It's been half a life time because 1980. (kiaavto.com)
More than half of women have this condition at some time during their life. (medlineplus.gov)
a year is a long time for an adult, but for a 2-year-old, it's half his life. (cdc.gov)

So, nobody told you that the gameplay in Half-Life 2 has almost nothing new. (ixbtlabs.com)
As soon as we had a small section of Half-Life gameplay up & running in VR, with Half-Life 2 assets, and added some rudimentary hand physics/interactions, it was really clear that Half-Life suited VR," Walker explained. (ign.com)
From our very earliest gameplay experiments on the project that ultimately became Half-Life: Alyx, it has been a VR-native experience. (ign.com)

As society becomes more unequal in so many other ways, life expectancy, too, is diverging. (npr.org)
An estimated 11% of the decline in life expectancy can be attributed to increases in deaths from accidents/unintentional injuries. (cdc.gov)
COVID-19 was responsible for 90% of the decline in life expectancy for the Hispanic population. (cdc.gov)
COVID-19 was responsible for 59% of the decline in life expectancy for the non-Hispanic black population. (cdc.gov)
COVID-19 was responsible for 68% of the decline in life expectancy for the non-Hispanic white population. (cdc.gov)

Sadly for console gamers, Half-Life: Alyx will certainly be an unique Heavy steam, which means that it will only be playable on PC. (2ig.cc)

The main challenge in extending the half-life of drugs is the development of safe, versatile and regulatory compliant technologies that enable medicine levels to be maintained in the bloodstream and avoid the degradation mechanisms that prey upon biologic therapies. (news-medical.net)
Short half-life in the bloodstream. (ynaevans.com)

The extension of half-life reduces the frequency of injections needed to provide therapeutic benefit. (news-medical.net)

Kendall Square in Cambridge, home to hundreds of technology and life science companies, is among the business centers most affected by a new law governing noncompete agreements. (wbur.org)
In medical centers caring for large numbers of children with perinatally acquired HIV infection, PCP has been the initial HIV-related illness for 8%-12% of all children and for greater than 50% of those children who progress to AIDS within the first year of life (2-6). (cdc.gov)

Children's organs are also still developing, so lasting damage can be done during a chemical outbreak, and their smaller physical size means they aren't able to use equipment like oxygen masks or life vests made for adult-sized faces and bodies. (cdc.gov)

For all but 6 studies, the MID estimates were close to one half a SD (mean = 0.495, SD = 0.155). (nih.gov)

January 12, 2013, I ran the Disney half marathon. (cdc.gov)
We understand now that my Disney half marathon training is what prepared my heart for the real life marathon I was to endure. (cdc.gov)

Looking for a VR headset for Half-Life: Alyx? (pcgamer.com)
Half-Life: Alyx is compatible with any VR headset that runs off your gaming PC. (ign.com)
The company says Index was "built hand-in-hand" with Half-Life: Alyx, but it comes at a steep price--the headset alone is $499, while the Index kit retails for $999. (gamespot.com)

The second half of the double bill comprises Sharon Eyal's HALF LIFE, which has been part of the Staatsballett Berlin's repertory since 2018. (staatsballett-berlin.de)

Road to VR suggests that Alyx is hinting specifically at a VR-based Half-Life 2: Episode Three equivalent , since it's so conspicuously letting players hold Gordon's crowbar. (theverge.com)

Like Matt, small details like being able to put a bucket on a headcrab and watch it panic helped crystalise what Half-Life in VR could be for me. (rockpapershotgun.com)

Half-Life 2: Episode Two ends with a cliffhanger. (theverge.com)
Half-Life: Alyx arrives 13 years after the series' last release, 2007's Half-Life 2: Episode 2 , which ended on a cliffhanger. (gamespot.com)

I played the final three hours of Half-Life: Alyx in a single session. (pcgamer.com)
It means that after 14 hours, half of the amount you've taken will be already gone from your body. (omnicalculator.com)
Let's assume that the Adderall's half-life is 12 hours and that the patient took 1 g of the drug. (omnicalculator.com)
Trenbolone acetate is a short-acting variant that has a half-life of 72 hours and is suggested to be inserted every second day at the very least. (ynaevans.com)

Marine's Journal: Last Stand is a survival horror singleplayer first person shooter mod for Half-Life (WON, and can do it for Steam) in a wold of infected zombies, playing in the role of Jonathan Kessler, a USA Marine survivor of the pendemic. (moddb.com)

More than half of the very old now live without a spouse, and we have fewer children than ever beforeyet we give virtually no thought to how we will live out our later years alone. (theatlantic.com)
When I need to be revitalised, I read A house for Mr. Biswas, now I can be totally revitalised for the next few years having read half a life, its brilliant! (bookbrowse.com)
The elf tells Kevin that, at 44, he's reached the midpoint of his life and he has a choice: he can carry on living as normal, until his death at 88 - or the elf can turn the clock back and Kevin will live the rest of his years in reverse. (theguardian.com)
An engineering degree went from having a half life of 35 years in ca. 1930 to about 10 years in 1960. (wikiwand.com)
A Delphi Poll showed that the half life of psychology as measured in 2016 ranged from 3.3 to 19 years depending on the specialty, with an average of a little over 7 years. (wikiwand.com)
Lead in bone has a biological half-life of about ten years. (wikidoc.org)
Plutonium in the liver has a biological half-life of about 40 years. (wikidoc.org)
Over the course of five years, Massachusetts will dole out roughly half a billion dollars to support the life sciences. (wbur.org)
Keiner argues that to human beings, the first 18 years of life seem just as long as the remaining 70. (youthrights.org)
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CHICAGO (AP) - An 80-year-old half-brother of the Rev. Jesse Jackson who was sentenced to life in prison more than 30 years ago after being convicted of hiring hit men has been released from prison, officials said. (whec.com)
once initiated, duration of treatment is unknown and will likely need to continue for several years, if not for life. (cdc.gov)
Given that chrysotile has a lung half-life of a few months and that mesothelioma has a latency period on the order of 20 to 30 years, it is unlikely that the chrysotile fibers found at autopsy are a meaningful indicator of historical exposure to chrysotile. (cdc.gov)

For some substances, it is important to think of the human or animal body as being made up of several parts, each with their own affinity for the substance, and each part with a different biological half-life. (wikidoc.org)
Trenbolone has a relatively short half-life, and once a user reaches maturity, he is likely to take smaller quantities of this substance than a non-abusing. (ynaevans.com)

Paradise: that elusive place where the anxieties, struggles, and burdens of life fall away. (netgalley.com)
The other half is lost in going through anxieties caused by others. (astrologyweekly.com)

Unfortunately for console gamers, Half-Life: Alyx will be a special Heavy steam, which suggests that it will only be usable on PC. (2ig.cc)

Furthermore, the low cost and low-dose frequency of this steroid (half-life 5 days) compared to trenbolone acetate (half-life 1 day) have increased its. (ynaevans.com)

Biological half-life is an important pharmacokinetic parameter and is usually denoted by the abbreviation t 1/2 . (wikidoc.org)
The biological half-life of water in a human is about 7 to 10 days. (wikidoc.org)
Drinking large amounts of alcohol will reduce the biological half-life of water in the body. (wikidoc.org)
The metabolite has a biological half-life of 4 to 16 days. (wikidoc.org)
Polonium in the body has a biological half-life of about 30 to 50 days. (wikidoc.org)
Caesium in the body has a biological half-life of about one to four months. (wikidoc.org)
The use of half-lives and associated confidence intervals in biological research. (cdc.gov)

An explanation for this consistency is that research in psychology has shown that the limit of people's ability to discriminate over a wide range of tasks is approximately 1 part in 7, which is very close to half a SD. (nih.gov)

Literate persons who do not read half a life, will die having had half a life, pardon the pun. (bookbrowse.com)
You can read everything we know about Half-Life: Alyx so far in our roundup, and you can check out the first Half-Life: Alyx trailer here. (gamespot.com)

While it's sandwiched between the events of Half-Life 1 and Half-Life 2 the repercussions of its story extend well into whatever future there is for the Half-Life series, and its technical accomplishments will leave other developers, once again, struggling to keep up. (pcgamer.com)
Why is it advantageous to extend drug half-life? (news-medical.net)

These ideas of half-life applied to different fields differ from the concept of half-life in physics in that there is no guarantee that the knowledge or facts in areas of study are declining exponentially. (wikiwand.com)

Describing the occasion as "a very big day for the life sciences community," Gov. Charlie Baker on Friday signed into law the Life Science Bond Bill at Bunker Hill Community College. (wbur.org)
The bill "ensures all of Massachusetts remains the best place in the world for life sciences," said Massachusetts Biotechnology Council President and CEO Robert Coughlin in a statement . (wbur.org)
In of Life Sciences, 14189 Huddinge, Sweden. (cdc.gov)

Trenbolone acetate 100mg, trenbolone hexahydrobenzylcarbonate Trenbolone half life, cheap order legal steroid paypal. (ynaevans.com)

This makes compliance less complicated for the patient and that translates into better quality of life. (news-medical.net)
The coupling of the Veltis technology with drug candidates results in products that are not only superior therapeutically, but that are preferred by patients due to their capability to improve quality of life by reducing the inconvenience of the daily or twice daily dosing regimens that are associated with some chronic medical conditions. (news-medical.net)
They were all interested in seeking freedom, economic opportunity, religious tolerance and a better quality of life for their children. (ipl.org)
A number of studies have computed the minimally important difference (MID) for health-related quality of life instruments. (nih.gov)
In most circumstances, the threshold of discrimination for changes in health-related quality of life for chronic diseases appears to be approximately half a SD. (nih.gov)
Palliative care focuses on improving the quality of life for people with serious illness. (mercurynews.com)
These services enhance the quality of life, making possible thoughtful choices during debilitating illness and at the end of life. (mercurynews.com)

The science behind Veltis exploits Novozymes' world leading research into the interaction of albumin and its natural cell surface receptor which substantially accounts for the native protein's 19 day half-life. (news-medical.net)
We have engineered a range of albumin variants with increased binding to the human FcRn receptor and have demonstrated that this increase in receptor binding correlates directly with an increased in vivo half-life. (news-medical.net)
A better, but not perfect, correspondence was observed between D 2 receptor dissociation and plasma QTP half-life. (researchgate.net)

In this culminating work, he brings together the outer world and the inner to offer us a surprising, original, often beautiful exploration of how we might come upon paradise in the midst of our very real lives. (netgalley.com)
Rug ged internet blacksmith show Man At Arms is no stranger to forging in real life what we could previously only play with through games or fiction. (tor.com)
And a 90 degree downslash is all it takes for the real Buster Sword to cleave a table in half. (tor.com)
Now, a new creature has been discovered that is part human and part snake - a real-life version of the mythical creature known as the Naga. (venomoussnakes.net)
The discovery of this real-life Naga was made by a team of researchers from India's National Institute of Advanced Studies (NIAS). (venomoussnakes.net)
The discovery of this real-life Naga is an exciting development that could have far-reaching implications for science and our understanding of evolution. (venomoussnakes.net)
While controversy remains about California's recently passed End of Life Option Act, we need to accept that aid-in-dying is now legal and that the state needs to support additional real options for patients-especially good palliative care with its focus on the whole-person and pain management. (mercurynews.com)

But if you want that make that gamer's holidays very merry, then Half-Life 2 is just the ticket. (extremetech.com)
Before going out, pills for erectile dysfunction over the counter Viagra Pill she learns viagra half life Is Your Best Choice to deploy three nests and four troops pills for erectile dysfunction over the counter Wholesale to make a false fire. (health.go.ug)
YouGov polled 2,504 adults about their spending on those extras that make life a little more fun and found that 68 percent of respondents said they skipped a recreational activity in the past year due to concerns about money . (bestlifeonline.com)
Why," the argument might go, "since I have been responsible for deciding about my health my whole life, should I be denied the opportunity to make the final-and arguably most important-decision of my life, how and when to die? (mercurynews.com)

In the course book on page 612, it mentions how in 1888, more than half a million Europeans landed in America. (ipl.org)

You can also drive a buggy in Half-Life 2, but you have already done that in the alpha version stolen a year ago. (ixbtlabs.com)
Gordon Freeman (who accidentally opened an inter-dimensional portal in Half-Life ) has reawakened from a 20-year stasis to find Earth conquered by the alien Combine. (theverge.com)
The law expands upon a 10-year, $1 billion life science bill introduced in 2008 by former Gov. Deval Patrick. (wbur.org)
About a year ago, WayForward released Shantae: Half-Genie Hero , the fourth entry in the studio's popular platforming franchise. (nintendolife.com)
WINDSOR, Conn., Feb. 26, 2010 - Total new annualized premium for individual life insurance declined five percent in the fourth quarter of 2009, resulting in a 15 percent reduction for the year as compared to 2008, according to LIMRA's quarterly individual life insurance sales survey. (limra.com)
For the year, variable products declined by half. (limra.com)
After single digit drops in the first two quarters of the year, whole life sales increased 12 percent in the third quarter and another 12 in the fourth quarter. (limra.com)
Overall, total individual life insurance policy count increased three percent for the quarter and dropped two percent for the year. (limra.com)
Every year on the anniversary of Roe, hundreds of thousands of pro-lifers attend the annual March for Life in Washington D.C. to remember the more than 55 million lives lost from abortion. (lifenews.com)
A population-based study in Massachusetts found the minimum incidence of PCP during the first year of life to be 2.3% among all infants born to seropositive mothers, or an estimated 7.7% among HIV-infected infants (7). (cdc.gov)

Through using the Veltis technology in the design of drugs, developers can now modify the half-life of their products to provide weekly, two-weekly, or even monthly dosing, while enhancing drug tolerability and efficacy. (news-medical.net)
His parents made statues to rash on end of penis sacrifice viagra half life Enhancement Products him. (health.go.ug)
Guaranteed death benefit universal life (GDBUL) sales only fell by about 11 percent in 2009, while non-death benefit guarantee UL products dropped 26 percent. (limra.com)
The objective of this study was to evaluate the reporting rate of hemorrhagic and thrombotic adverse drug reactions (ADRs) associated with nonreplacement (emicizumab) and replacement extended half-life (EHL) factor VIII (FVIII) products as retrieved from the EudraVigilance database. (bvsalud.org)

A series of 40 bitesize questions, turned into your own life story question and answer book. (99designs.com)

CareerPivot.com is one of the very few websites dedicated to those of us in the second half of life and our careers. (libsyn.com)
Psychological developments in the second half of life. (bvsalud.org)

Although Bihen was in the second class, How long does viagra half life he relied on his viagra half life Is Your Best Choice love with Baoyu and didn t put everyone in the eyes. (health.go.ug)
Trenbolone enanthate: tren-e is the long, slow acting ester with a half-life of about 19-days. (ynaevans.com)
The world of mythology has long been filled with tales of creatures that are half human and half animal. (venomoussnakes.net)

In the development of new drugs, obstacles are often encountered with the short therapeutic half-lives of many peptides and proteins. (news-medical.net)
due to its short half-life, its dose sometimes has to be repeated. (omnicalculator.com)
For anyone contemplating one of these short anabolic cycles we will go over the best types of steroids to use together as well as the ester half life of the. (ynaevans.com)

Anatomy2

Organisms2

Diseases1

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Psychiatry and Psychology7

Phenomena and Processes16

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture1

Humanities2

Information Science5

Health Care21

Geographicals1

The bioavailability, dispostion kinetics and dosage of sulphadimethoxine in dogs. (1/6090)

Cocaine metabolite kinetics in the newborn. (2/6090)

Re-entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species. (3/6090)

Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. (4/6090)

Protection against lymphocytic choriomeningitis virus infection induced by a reduced peptide bond analogue of the H-2Db-restricted CD8(+) T cell epitope GP33. (5/6090)

In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. (6/6090)

Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model. (7/6090)

Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. (8/6090)

Half-Life

Gold Radioisotopes

Quality of Life

Water Intoxication

Caustics

Antipyrine

Dosage Forms

Metabolic Clearance Rate

Biological Availability

Chemical Industry

Kinetics

Injections, Intravenous

Time Factors

Administration, Oral

Pharmacokinetics

Tissue Distribution

Occupational Exposure

Area Under Curve

Life

Diazepam

Valproic Acid

Enzyme Stability

Cycloheximide

Dose-Response Relationship, Drug

RNA, Messenger

Molecular Sequence Data

Infusions, Intravenous

Chromatography, High Pressure Liquid

Liver

Base Sequence

Amino Acid Sequence

Rabbits

Life Change Events

Cell Line

Life Cycle Stages

Questionnaires

Life Tables

Life Support Care

Life Style

Longevity

Health Status

Sickness Impact Profile

Treatment Outcome

Age Factors

Insurance, Life

Cross-Sectional Studies

Prospective Studies

Follow-Up Studies

Activities of Daily Living

Pregnancy

Stress, Psychological

Personal Satisfaction

Risk Factors

Psychometrics

United States

Severity of Illness Index

Health Status Indicators

Biogenesis

Adaptation, Psychological

Depression

Socioeconomic Factors

Cost-Benefit Analysis

Cohort Studies

Life Support Systems

The bioavailability, dispostion kinetics and dosage of sulphadimethoxine in dogs. (1/6090)

Cocaine metabolite kinetics in the newborn. (2/6090)

Re-entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species. (3/6090)

Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. (4/6090)

Protection against lymphocytic choriomeningitis virus infection induced by a reduced peptide bond analogue of the H-2Db-restricted CD8(+) T cell epitope GP33. (5/6090)

In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. (6/6090)

Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model. (7/6090)

Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. (8/6090)

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