The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
A condition resulting from the excessive retention of water with sodium depletion.
Strong alkaline chemicals that destroy soft body tissues resulting in a deep, penetrating type of burn, in contrast to corrosives, that result in a more superficial type of damage via chemical means or inflammation. Caustics are usually hydroxides of light metals. SODIUM HYDROXIDE and potassium hydroxide are the most widely used caustic agents in industry. Medically, they have been used externally to remove diseased or dead tissues and destroy warts and small tumors. The accidental ingestion of products (household and industrial) containing caustic ingredients results in thousands of injuries per year.
An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)
The rate dynamics in chemical or physical systems.
Injections made into a vein for therapeutic or experimental purposes.
Elements of limited time intervals, contributing to particular results or situations.
The giving of drugs, chemicals, or other substances by mouth.
Dynamic and kinetic mechanisms of exogenous chemical and DRUG LIBERATION; ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and DRUG TOXICITY as a function of dosage, and rate of METABOLISM. LADMER, ADME and ADMET are abbreviations for liberation, absorption, distribution, metabolism, elimination, and toxicology.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
The state that distinguishes organisms from inorganic matter, manifested by growth, metabolism, reproduction, and adaptation. It includes the course of existence, the sum of experiences, the mode of existing, or the fact of being. Over the centuries inquiries into the nature of life have crossed the boundaries from philosophy to biology, forensic medicine, anthropology, etc., in creative as well as scientific literature. (Random House Unabridged Dictionary, 2d ed; Dr. James H. Cassedy, NLM History of Medicine Division)
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.
The extent to which an enzyme retains its structural conformation or its activity when subjected to storage, isolation, and purification or various other physical or chemical manipulations, including proteolytic enzymes and heat.
Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
The relationship between the dose of an administered drug and the response of the organism to the drug.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Those occurrences, including social, psychological, and environmental, which require an adjustment or effect a change in an individual's pattern of living.
Established cell cultures that have the potential to propagate indefinitely.
The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.
Care provided patients requiring extraordinary therapeutic measures in order to sustain and prolong life.
Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)
The normal length of time of an organism's life.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
A quality-of-life scale developed in the United States in 1972 as a measure of health status or dysfunction generated by a disease. It is a behaviorally based questionnaire for patients and addresses activities such as sleep and rest, mobility, recreation, home management, emotional behavior, social interaction, and the like. It measures the patient's perceived health status and is sensitive enough to detect changes or differences in health status occurring over time or between groups. (From Medical Care, vol.xix, no.8, August 1981, p.787-805)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Insurance providing for payment of a stipulated sum to a designated beneficiary upon death of the insured.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The performance of the basic activities of self care, such as dressing, ambulation, or eating.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Stress wherein emotional factors predominate.
The individual's experience of a sense of fulfillment of a need or want and the quality or state of being satisfied.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Assessment of psychological variables by the application of mathematical procedures.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The measurement of the health status for a given population using a variety of indices, including morbidity, mortality, and available health resources.
The origin of life. It includes studies of the potential basis for life in organic compounds but excludes studies of the development of altered forms of life through mutation and natural selection, which is BIOLOGICAL EVOLUTION.
A state of harmony between internal needs and external demands and the processes used in achieving this condition. (From APA Thesaurus of Psychological Index Terms, 8th ed)
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
Social and economic factors that characterize the individual or group within the social structure.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Systems that provide all or most of the items necessary for maintaining life and health. Provisions are made for the supplying of oxygen, food, water, temperature and pressure control, disposition of carbon dioxide and body waste. The milieu may be a spacecraft, a submarine, or the surface of the moon. In medical care, usually under hospital conditions, LIFE SUPPORT CARE is available. (From Webster's New Collegiate Dictionary)

The bioavailability, dispostion kinetics and dosage of sulphadimethoxine in dogs. (1/6090)

The disposition kinetics of sulphadimethoxine were studied in six normal beagle dogs after intravenous injection of a single dose (55 mg/kg). The median (range) distribution and elimination half times of the drug were 2.36 (2.06-3.35) hours and 13.10 (9.71-16.50) hours, respectively. Total body clearance of the drug had a median value of 21.7 ml/kg/h and a mean value of 21.4 ml/kg/h. While the overall tissue to plasma level ratio (k12/k21) of the drug was 0.55 after distribution equilibrium had been attained, analogue computer simulated curves showed that at 24 hours the fractions (percentage) of the dose in the central and tissue compartments were 12 and 11%, respectively. The drug was shown, by equilibrium dialysis method, to be highly bound to plasma proteins (greater than 75%) within the usual therapeutic range (50 to 150 mug/ml) of plasma levels. The systemic availability of sulphadimethoxine from the oral suspension was 32.8% (22.5-80.0). Since the absorption half time, 1.87 (0.86-3.22) hours, was considerably shorter than the half-life, 13.10 (9.71-16.50) hours, of the drug, the rate of absorption would have little influence on the dosage regimen. Based on the experimental data obtained, a satisfactory dosage regimen might consist of a priming dose of 55 mg/kg by the intravenous route and maintenance doses of either 27.5 mg/kg of sulphadimethoxine injection given intravenously or 55 mg/kg of the oral suspension administered at 24 hour intervals. The adequacy and duration of therapy will depend upon the clinical response obtained.  (+info)

Cocaine metabolite kinetics in the newborn. (2/6090)

The study goal was to determine the half-life elimination of cocaine and benzoylecgonine (BZE) in the newborn. Three 0.3-mL blood samples were collected during the first day of life. Urine was collected once daily. Cocaine and BZE concentrations were determined by gas chromatography-mass spectrometry. An extraction method was developed for measuring low concentrations of cocaine and BZE in small (0.1 mL) blood samples. Cocaine had a half-life of 11.6 h in one subject. The half-life of BZE during the first day of life, based on blood data in 13 subjects, was 16 h (95% confidence interval [CI], 12.8 to 21.4 h). The half-life of BZE during the first week of life, based on urine data in 16 subjects, was 11.2 h (95% CI, 10.1 to 11.8 h). The novel extraction method for small blood sample volumes should be applicable to other basic drugs.  (+info)

Re-entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species. (3/6090)

Misfolded or unassembled secretory proteins are retained in the endoplasmic reticulum (ER) and subsequently degraded by the cytosolic ubiquitin-proteasome system. This requires their retrograde transport from the ER lumen into the cytosol, which is mediated by the Sec61 translocon. It had remained a mystery whether ER-localised soluble proteins are at all capable of re-entering the Sec61 channel de novo or whether a permanent contact of the imported protein with the translocon is a prerequisite for retrograde transport. In this study we analysed two new variants of the mutated yeast carboxypeptidase yscY, CPY*: a carboxy-terminal fusion protein of CPY* and pig liver esterase and a CPY* species carrying an additional glycosylation site at its carboxy-terminus. With these constructs it can be demonstrated that the newly synthesised CPY* chain is not retained in the translocation channel but reaches its ER lumenal side completely. Our data indicate that the Sec61 channel provides the essential pore for protein transport through the ER membrane in either direction; persistent contact with the translocon after import seems not to be required for retrograde transport.  (+info)

Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. (4/6090)

The long-term administration of L-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue. After i.p. injection of L-carnitine, the concentration of free carnitine in heart remained constant, although serum free carnitine level increased up to 80-fold. On the other hand, a significant increase in short-chain acyl-carnitine level in heart was observed. These results suggest that increased levels of short-chain acyl-carnitine, not free carnitine, might be a key compound in the protective effect of L-carnitine administration in JVS mice.  (+info)

Protection against lymphocytic choriomeningitis virus infection induced by a reduced peptide bond analogue of the H-2Db-restricted CD8(+) T cell epitope GP33. (5/6090)

Recent investigations have suggested that pseudopeptides containing modified peptide bonds might advantageously replace natural peptides in therapeutic strategies. We have generated eight reduced peptide bond Psi(CH2-NH) analogues corresponding to the H-2Db-restricted CD8(+) T cell epitope (called GP33) of the glycoprotein of the lymphocytic choriomeningitis virus. One of these pseudopeptides, containing a reduced peptide bond between residues 6 and 7 (Psi(6-7)), displayed very similar properties of binding to major histocompatibility complex (MHC) and recognition by T cell receptor transgenic T cells specific for GP33 when compared with the parent peptide. We assessed in vitro and in vivo the proteolytic resistance of GP33 and Psi(6-7) and analyzed its contribution to the priming properties of these peptides. The Psi(6-7) analogue exhibited a dramatically increased proteolytic resistance when compared with GP33, and we show for the first time that MHC-peptide complexes formed in vivo with a pseudopeptide display a sustained half-life compared with the complexes formed with the natural peptide. Furthermore, in contrast to immunizations with GP33, three injections of Psi(6-7) in saline induced significant antiviral protection in mice. The enhanced ability of Psi(6-7) to induce antiviral protection may result from the higher stability of the analogue and/or of the MHC-analogue complexes.  (+info)

In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. (6/6090)

The widely used anticancer prodrug cyclophosphamide (CPA) is activated in liver by a 4-hydroxylation reaction primarily catalyzed by cytochrome P-4502B and P-4502C enzymes. An alternative metabolic pathway involves CPA N-dechloroethylation to yield chloroacetaldehyde (CA), a P-4503A-catalyzed deactivation/neurotoxication reaction. The in vivo modulation of these alternative, competing pathways of P-450 metabolism was investigated in pharmacokinetic studies carried out in the rat model. Peak plasma concentrations (Cmax) for 4-OH-CPA and CA were increased by 3- to 4-fold, and apparent plasma half-lives of both metabolites were correspondingly shortened in rats pretreated with phenobarbital (PB), an inducer of P-4502B and P-4503A enzymes. However, PB had no net impact on the extent of drug activation or its partitioning between these alternative metabolic pathways, as judged from AUC values (area-under-the-plasma concentration x time curve) for 4-OH-CPA and CA. The P-4503A inhibitor troleandomycin (TAO) decreased plasma Cmax and AUC of CA (80-85% decrease) without changing the Cmax or AUC of 4-OH-CPA in uninduced rats. In PB-induced rats, TAO decreased AUCCA by 73%, whereas it increased AUC4-OH-CPA by 93%. TAO thus selectively suppresses CPA N-dechloroethylation, thereby increasing the availability of drug for P-450 activation via 4-hydroxylation. By contrast, dexamethasone, a P-4503A inducer and antiemetic widely used in patients with cancer, stimulated large, undesirable increases in the Cmax and AUC of CA (8- and 4-fold, respectively) while reducing the AUC of the 4-hydroxylation pathway by approximately 60%. Tumor excision/in vitro colony formation and tumor growth delay assays using an in vivo 9L gliosarcoma solid tumor model revealed that TAO suppression of CPA N-dechloroethylation could be achieved without compromising the antitumor effect of CPA. The combination of PB with TAO did not, however, enhance the antitumor activity of CPA, despite the approximately 2-fold increase in AUC4-OH-CPA, suggesting that other PB-inducible activities, such as aldehyde dehydrogenase, may counter this increase through enhanced deactivation of the 4-hydroxy metabolite. Together, these studies demonstrate that the P-4503A inhibitor TAO can be used to effectively modulate CPA metabolism and pharmacokinetics in vivo in a manner that decreases the formation of toxic metabolites that do not contribute to antitumor activity.  (+info)

Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model. (7/6090)

The effect of inoculum size (N0) on antimicrobial action has not been extensively studied in in vitro dynamic models. To investigate this effect and its predictability, killing and regrowth kinetics of Staphylococcus aureus and Escherichia coli exposed to monoexponentially decreasing concentrations of trovafloxacin (as a single dose) and ciprofloxacin (two doses at a 12-h interval) were compared at N0 = 10(6) and 10(9) CFU/ml (S. aureus) and at N0 = 10(6), 10(7), and 10(9) CFU/ml (E. coli). A series of pharmacokinetic profiles of trovafloxacin and ciprofloxacin with respective half-lives of 9.2 and 4 h were simulated at different ratios of area under the concentration-time curve (AUC) to MIC (in [micrograms x hours/milliliter]/[micrograms/milliliter]): 58 to 466 with trovafloxacin and 116 to 932 with ciprofloxacin for S. aureus and 58 to 233 and 116 to 466 for E. coli, respectively. Although the effect of N0 was more pronounced for E. coli than for S. aureus, only a minor increase in minimum numbers of surviving bacteria and an almost negligible delay in their regrowth were associated with an increase of the N0 for both organisms. The N0-induced reductions of the intensity of the antimicrobial effect (IE, area between control growth and the killing-regrowth curves) were also relatively small. However, the N0 effect could not be eliminated either by simple shifting of the time-kill curves obtained at higher N0s by the difference between the higher and lowest N0 or by operating with IEs determined within the N0-adopted upper limits of bacterial numbers (IE's). By using multivariate correlation and regression analyses, linear relationships between IE and log AUC/MIC and log N0 related to the respective mean values [(log AUC/MIC)average and (log N0)average] were established for both trovafloxacin and ciprofloxacin against each of the strains (r2 = 0.97 to 0.99). The antimicrobial effect may be accurately predicted at a given AUC/MIC of trovafloxacin or ciprofloxacin and at a given N0 based on the relationship IE = a + b [(log AUC/MIC)/(log AUC/MIC)average] - c [(log N0)/(log N0)average]. Moreover, the relative impacts of AUC/MIC and N0 on IE may be evaluated. Since the c/b ratios for trovafloxacin and ciprofloxacin against E. coli were much lower (0.3 to 0.4) than that for ampicillin-sulbactam as examined previously (1.9), the inoculum effect with the quinolones may be much less pronounced than with the beta-lactams. The described approach to the analysis of the inoculum effect in in vitro dynamic models might be useful in studies with other antibiotic classes.  (+info)

Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. (8/6090)

Liposomal aminoglycosides have been shown to have activity against intracellular infections, such as those caused by Mycobacterium avium. Amikacin in small, low-clearance liposomes (MiKasome) also has curative and prophylactic efficacies against Pseudomonas aeruginosa and Klebsiella pneumoniae. To develop appropriate dosing regimens for low-clearance liposomal amikacin, we studied the pharmacokinetics of liposomal amikacin in plasma, the level of exposure of plasma to free amikacin, and urinary excretion of amikacin after the administration of single-dose (20 mg/kg of body weight) and repeated-dose (20 mg/kg eight times at 48-h intervals) regimens in rhesus monkeys. The clearance of liposomal amikacin (single-dose regimen, 0.023 +/- 0.003 ml min-1 kg-1; repeated-dose regimen, 0.014 +/- 0.001 ml min-1 kg-1) was over 100-fold lower than the creatinine clearance (an estimate of conventional amikacin clearance). Half-lives in plasma were longer than those reported for other amikacin formulations and declined during the elimination phase following administration of the last dose (from 81.7 +/- 27 to 30.5 +/- 5 h). Peak and trough (48 h) levels after repeated dosing reached 728 +/- 72 and 418 +/- 60 micrograms/ml, respectively. The levels in plasma remained > 180 micrograms/ml for 6 days after the administration of the last dose. The free amikacin concentration in plasma never exceeded 17.4 +/- 1 micrograms/ml and fell rapidly (half-life, 1.47 to 1.85 h) after the administration of each dose of liposomal amikacin. This and the low volume of distribution (45 ml/kg) indicate that the amikacin in plasma largely remained sequestered in long-circulating liposomes. Less than half the amikacin was recovered in the urine, suggesting that the level of renal exposure to filtered free amikacin was reduced, possibly as a result of intracellular uptake or the metabolism of liposomal amikacin. Thus, low-clearance liposomal amikacin could be administered at prolonged (2- to 7-day) intervals to achieve high levels of exposure to liposomal amikacin with minimal exposure to free amikacin.  (+info)

the rate of cholesterol synthesis in the liver shows diurnal periodicity, with production peaking at nighttime. statins act by inhibiting the enzyme HMG CoA reductase, which controls synthesis of cholesterol in the liver. Most manufacturers of statins recommend that they are taken at night, on the basis of physiological studies. Simvastatin, marketed under the trade name Zocor among others, is a lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid (fat) levels. It is also used to decrease the risk of heart problems in those at high risk. It is taken by mouth. Serious side effects may include muscle Biological half-life‎: ‎2 hours for simvastatin and.. To maximize the products of statins plasma half life simvastatin a short half-life, fluvastatin, lovastatin, and simvastatin should be bad at plasma half life simvastatin allowing the greatest drug generic to be used during peak endogenous cholesterol common. The long really-life of ...
Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients
Montelukast. Absorption. It gets rapidly absorbed by the body. The mean plasma concentration is achieved in 3 to 4hrs. The oral bioavailability is about 64%. The bioavailability of the drug is not influenced by meals.. Distribution. About 99% of the drug is bound to plasma proteins. The volume of distribution is about 8-11 liters. The metabolism of the drug is liver by CYP3A4, 2C8 and 2C9.. Excretion The plasma clearance of montelukast is 45ml/min. Most of the drug is excreted through bile. The plasma half life is 2.7-5.5 hrs.. Levocetirizine Absorption. It is well absorbed in the body with mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours. Distribution It is well distributed in the body with 93% plasma protein binding. Vd is 0.41kg. Excretion. The plasma half life is 7.9 ± 1.9 hours; total body clearance is 0.63 ml/min/kg. ...
The biological half-life of synthetic, radiochemically pure, biologically active [3H]1-deamino-8-D-arginine-vasopressin (dDAVP) in rats was found to be 5.33 +/- 0.28 (S.E.M.) min in the initial, transitional, fast phase and 56.28 +/- 3.27 min in the second, slow phase. The substance accumulated to the greatest extent in the kidney and small intestine and only slightly in the adenohypophysis. The results have suggested that the extended biological half-life may play a role in the more marked and longer antidiuretic effect of dDAVP. The explanation of the poor accumulation in the adenohypophysis may be that dDAVP does not possess an effect similar to that of corticotrophin releasing factor.
Following intravenous infusion, verapamil is eliminated bi-exponentially, with a rapid early distribution phase (half-life about four minutes) and a slower terminal elimination phase (half-life two to five hours). Following oral administration, the elimination half-life is three to seven hours. Approximately 50% of an administered dose is eliminated renally within 24 hours, 70% within five days. Up to 16% of a dose is excreted in the feces. About 3% to 4% of renally excreted drug is excreted as unchanged drug. The total clearance of verapamil is nearly as high as the hepatic blood flow, approximately 1 L/h/kg (range: 0.7-1.3 L/h/kg ...
The interest in developing peptide and protein drugs has been shadowed by their short elimination half-life and impermeability through biological membranes. Pegylation is widely attempted to extend their half-lives. However, pegylation results in heterogeneous species, leading to inconsistent drug efficacy, immunogenecity and side effects. An at least-equally-efficient delivery system that produces homogenous species is highly desired to substitute pegylation. Reversible lipidization takes a unique approach by conjugating fatty acids specifically to cysteines of peptide and protein through reducible disulfide linkage. This approach produces a single form of site-specific and controlled-release conjugate.; Using this approach, we successfully lipidized octreotide (OCT) and Tyr3-octreotide (TOC). Lipidization augmented the pharmacological effect of OCT on inhibiting growth hormone release in growth hormone releasing factor (GRF)-stimulated rats. Further pharmacokinetic studies demonstrated that ...
The kinetics of distribution of di-propranolol (P) to various organs and tissues were studied in the rat after an i.v. dose of 2 mg/kg. The disposition of the drug can be adequately described by a two-compartment open model with a distribution half-life of 4.8 min, a terminal blood half-life of 63 min and an apparent volume of distribution beta of 8.5 liters/kg. Higher tissue concentrations were found to be present in heart, brain and kidney. Although the disappearance rate of P from abdominal aorta, muscles, adipose tissue and whole brain paralleled that of blood, the elimination rate constant for atria and kidney was significantly reduced suggesting a specific binding of P. After an i.v. dose of 5 mg/kg, P distributed rapidly to various brain areas following a vascularity pattern with higher concentrations in cortical areas of earlier times. An equilibrium between various brain areas was observed at 2 to 3 hr after dosing. There was a parallel decay of P concentrations in the blood and in ...
The disposition of (5H-dibenzo[a,d]cyclohepten-5-ylidene)acetic acid (Wy-41,770), an anti-inflammatory agent, was investigated in rats, mice, rhesus monkeys, and dogs following single 12.5-mg/kg doses of 14C-labeled or unlabeled drug and in rodents receiving single 225-mg/kg doses of 14C-Wy-41,770. The drug was rapidly and well absorbed in all four animal species. Following an iv dose, plasma elimination half-lives of Wy-41,770 in monkeys and dogs were, respectively, 5.0 +/- 1.8 and 0.24 +/- 0.01 hr. Total body clearances (CL) of 1.8 +/- 0.2 ml/min/kg in monkeys and 7.7 +/- 1.1 ml/min/kg in dogs are low, indicating that, after an ig dose, little Wy-41,770 would be eliminated on first passage through the liver. The steady state volumes of distribution of 0.37 +/- 0.1 and 0.14 +/- 0.01 liters/kg, respectively, in monkeys and dogs are low, indicating limited extravascular distribution of Wy-41,770. Plasma half-lives of Wy-41,770 in rats and mice were, respectively, 10.8 and 8.4 hr. The longer ...
The mean serum concentrations of ciprofloxacin associated with a statistically significant improvement in survival in the rhesus monkey model of inhalational anthrax are reached or exceeded in adult and paediatric patients receiving oral and intravenous regimens (see Section 4.2 Dose and Method of Administration). Ciprofloxacin pharmacokinetics have been evaluated in various human populations. The mean peak serum concentration achieved at steady state in human adults receiving 500 mg orally every 12 hours is 2.97 microgram/mL, and 4.56 microgram/mL following 400 mg intravenously every 12 hours. The mean trough serum concentration at steady state for both of these regimens is 0.2 microgram/mL. In a study of 10 paediatric patients between 6 and 16 years of age, the mean peak plasma concentration achieved is 8.3 microgram/mL and trough concentrations range from 0.09 to 0.26 microgram/mL, following two 30-minute intravenous infusions of 10 mg/kg administered 12 hours apart. After the second ...
The mechanism of action of azithromycin is by inhibiting protein synthesis by bacteria, due to its 50S ribosomal binding lasubunidad avoiding peptide translocation.. After oral administration in humans, azithromycin is widely distributed throughout the body. Its bioavailability is about 37%. Administering azithromycin capsules after a large meal subiodisponibilidad decreases by at least 50%. The time required to reach peak plasma levels is two to three hours. Terminal half-life of plasma elimination half-life closely reflects tissue depletion two to four days.. In elderly volunteers (aged 65 years), after a five-day regimen were observed values ​​of area under the curve (AUC) slightly higher than those observed in younger volunteers (under 40 years) but these do not were considered clinically significant, and therefore is not recommended dosage adjustment.. In patients with moderate renal impairment (creatinine clearance less than 40 ml / min), no evidence of significant changes in ...
Esmolol is rapidly metabolized by hydrolysis of the ester linkage, chiefly by the esterases in the cytosol of red blood cells and not by plasma cholinesterases or red cell membrane acetylcholinesterase. Total body clearance in man was found to be about 20 L/kg/hr, which is greater than cardiac output; thus the metabolism of esmolol is not limited by the rate of blood flow to metabolizing tissues such as the liver or affected by hepatic or renal blood flow. Esmolol has a rapid distribution half-life of about 2 minutes and an elimination half-life of about 9 minutes.. Using an appropriate loading dose, steady-state blood levels of esmolol hydrochloride for dosages from 50 to 300 mcg/kg/min are obtained within five minutes. Steady-state is reached in about 30 minutes without the loading dose. Steady-state blood levels of esmolol increase linearly over this dosage range and elimination kinetics are dose-independent over this range. Steady-state blood levels are maintained during infusion but ...
Esmolol is rapidly metabolized by hydrolysis of the ester linkage, chiefly by the esterases in the cytosol of red blood cells and not by plasma cholinesterases or red cell membrane acetylcholinesterase. Total body clearance in man was found to be about 20 L/kg/hr, which is greater than cardiac output; thus the metabolism of esmolol is not limited by the rate of blood flow to metabolizing tissues such as the liver or affected by hepatic or renal blood flow. Esmolol has a rapid distribution half-life of about 2 minutes and an elimination half-life of about 9 minutes. Using an appropriate loading dose, steady-state blood levels of BREVIBLOC injection for dosages from 50-300 mcg/kg/min are obtained within five minutes. Steady-state is reached in about 30 minutes without the loading dose. Steady-state blood levels of esmolol increase linearly over this dosage range and elimination kinetics are dose-independent over this range. Steady-state blood levels are maintained during infusion but decrease ...
Belatacept is an intravenously infused selective T cell costimulation blocker approved for preventing organ rejection in renal transplant recipients aged ≥18 years. This phase I trial examined the pharmacokinetics and pharmacodynamics (percentage CD86 receptor occupancy [%CD86RO]) of a single dose of belatacept (7.5 mg/kg) administered to kidney transplant recipients aged 12-17 years receiving a stable calcineurin inhibitor-based immunosuppressive regimen. Nine adolescents (mean age 15.1 years) who were seropositive for Epstein-Barr virus were enrolled; all completed the 6-month study. Pharmacokinetics suggested relatively low variability of exposure (coefficients of variation for maximum observed serum concentration [C max ] and area under the serum concentration-time curve from time zero extrapolated to infinity [AUC 0-INF ] were 20% and 25%, respectively). Mean half-life (T 1/2 ) occurred 7.2 days postinfusion. Belatacept total body clearance was 0.48 mL/h/kg, and volume of distribution at ...
In a randomized, double-blind, placebo-controlled, multiple-dose pharmacokinetic study, the safety and effect on intestinal flora of sparfloxacin (SPX) were determined in 12 healthy male volunteers (8 received SPX and 4 received a placebo). Following fasting and oral administration of 400 mg on day 1 and 200 mg on days 2 to 8, concentrations of the free drug in serum, urine, and feces were measured by high-performance liquid chromatography; serum and urine were also evaluated by a microbiological assay. All results, except those for renal excretion, exclude the glucuroconjugate metabolite. A mean peak concentration in serum (400-mg dose) of 0.56 +/- 0.13 mg/liter was measured 3.52 +/- 0.98 h after administration. Pharmacokinetic parameters (measured by high-performance liquid chromatography) were based on an open, one-compartment model and resulted in the following day 1 (calculated for the 200-mg dose), day 4 (recalculated for a single dose), and day 8 values (mean +/- standard deviation): area ...
The pharmacokinetics and oral bioavailability of 1,3-di(4-imidazolino-2-methoxyphenoxy) propane.lactate (DMP) was determined in male dogs following iv and po administrations of DMP.lactate containing trace amounts of [14C]DMP.HCl. Following the iv administration of [14C]DMP.lactate (2.5 mg/kg), plasma concentrations of DMP declined in a biexponential manner and were measurable to 48 hr. The terminal elimination half-life was 37.7 hr. The mean AUC0-infinity of DMP was 1.58 micrograms.hr/ml. The volume of distribution was 89 liters/kg and the body clearance was 27 ml/min/kg. The disposition of total radioactivity was similar to that of DMP. Approximately 14% of the dose was eliminated in urine as DMP or total radioactivity. Renal clearance was 10% of the body clearance. Following the po administration of [14C]DMP.lactate (14 mg/kg) the mean Cmax of total radioactivity and DMP was 0.20 and 0.17 micrograms/ml, respectively. The respective mean AUC0-T was 0.37 and 0.21 micrograms.hr/ml. The mean oral ...
The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half. It usually
(KudoZ) English to French translation of mean peak serum concentration: Valeur moyenne du pic de concentration sérique ou Cmax moyenne [notice de médicament - Medical: Pharmaceuticals (Medical)].
by Drugs.com It usually takes around 5.5 x elimination half-life (hours) before a drug is completely cleared from your system. So if we take the maximum elimination half life of 22 hours, it would take 121 hours (5.5 x 22 hours) approximately 5 days before the medicine is eliminated from your system ...
There's been a lot of Half-Life 2 talk lately, what with Marc Laidlaw creatively writing some gender-swapped fan fiction that revealed his vision for the missing Episode 3 and Lever Softworks speeding up the release schedule of its Half-Life 2: Aftermath mod. In fact, it feels like there there's pretty much always a bit of Half-Life 2 chatter drifting around because it's a celebrated hunk of first-person shootery and we're still wondering (well, maybe not so much now) if we'll ever see Half-Life 3.It wasn't this most recent surge of Half-Life 2 nostalgia that led me to play through the final chapter of Half-Life 2 a total of 15 times in 2 days. I love Half-Life 2, and I'll still play certain chapters of it every now and then. But when I play it, I never play the last chapter, and I didn't want to this week, and I certainly didn't want to play it 15 times in two days. Also: I'll never play it again.Why I played it this week: I was working on
In article ,hraaxl.4.00091AB1 at marc.cri.nz,, hraaxl at marc.cri.nz says: , ,Dear everyone , ,Heres the problem. I want to set up an assay system. The system has to have a ,flourescent product or produce light (eg like GUS or luciferase) and most ,importantly have a short as possible half life in the cell. So, GUS I believe ,might not be ideal because its supposed to have a long half life. Perhaps ,luciferase would be better? , ,So one question is, what is the half life of GUS and luciferase in the ,cell? , ,And secondly (and more importantly) if anyone knows of another enzyme (I have ,to be to get the clone as well) I could use to do the equivalent job Id be ,very grateful. , ,Thanks , ,Tony Lough ,HortResearch ,New Zealand , , CAT has a half life of about 50 hrs in mammalian cells and Luciferase has a half life of about 3 hrs. I dont know about GUS. another potential reporter gene is B-gal which I think also has a long half life but I cant recall what it is. Jeff Silverman NCI, NIH ...
Pharmacokinetics of LGT209: Area under the serum concentration-time curve from time zero to the time of the last quantifiable concentration (AUC0-last) of LGT209 in patients and healthy volunteers following intravenous administration [ Time Frame: Day 1 (1, 2, 4, 6, 8, 12 hrs post dose); Post-dose at 24 hr (Day 2) 48 hr (Day 3), 96 hr (Day 5), Days 8, 11, 15, 22, 29, 43, 57, 71, 85, 113, 141 ...
The ADME characteristics were investigated by the oral and IV routes in the rat. The bioavailability after the oral low and high doses were , 100% and approximately 50%, respectively. However, the bioavailability for the high dose was calculated using a lower IV dose. In addition, less than 1% of the parent compound was found in the faeces after the oral high dose, indicating practically complete absorption from the gastrointestinal tract. Therefore, 100% absorption by the oral route is assumed and is taken forward to risk characterisation. No sex difference was observed in blood kinetics at the low dose, however, in the high dose group, Cmax and AUC were higher in females than males. The elimination half life was 99-113 hours, irrespective of the dose, route or sex. The retention of radioactivity was low, with the majority (60%) of the radioactivity excreted by biliary route within 3 days of dosing. Approximately 20% was excreted in urine and a small amount of radioactivity exhaled as14CO2. ...
We'll probably never get another Half-Life game, but where official Valve canon fails us, series writer Marc Laidlaw does not. The former Valve employee who wrote Half-Life, Half-Life 2, and both of Half-Life 2's episodes has shared a fictional letter on his personal site that, once you swap around some proper nouns, sure reads like a plot summary of where the series would have gone after the events of Half-Life 2: Episode 2. To all intents and purposes, its the closest we have for an official synopsis for Half-Life 3.
drugbox IUPAC name = CAS number = ATC prefix = B01 ATC suffix = AB06 PubChem = DrugBank = chemical formula = molecular weight = Mean MW = 4500 Daltons bioavailability = protein bound = metabolism = elimination half life = excretion = pregnancy AU
Synthesis of a specific secretory protein was followed in the presence of actinomycin D and cordycepin (3-deoxyadenosine). The apparent half-life of the messenger RNA for this protein is significantly longer in the presence of actinomycin D than in the presence of cordycepin. These results suggest that actinomycin D studies of half-life in specialized cells may be inaccurate. ...
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Writers: Maja Thim Larsena, Helen Rawsthorneb etc. - Published: October 10th 2018 - Publication: Journal of Controlled Release 287 (2018) 132-141
Results: Sixteen patients (median age 46 years, range 26-73) with non-small-cell lung cancer (NSCLC; n=5), colorectal cancer (CRC; n=4) or other tumor type (n=7) were enrolled and received treatment with cediranib at doses of 10 (n=3), 20 (n=3), 30 (n=3) or 45 (n=7) mg/day. The most common adverse events (AE) observed were diarrhea, fatigue, hypertension, hand-foot syndrome and proteinuria. No dose-limiting toxicities (DLTs) were observed at doses ≤30 mg/day. At 45 mg/day, 3/6 evaluable patients experienced a total of four DLTs (proteinuria, n=2; diarrhea, n=1; thrombocytopenia, n=1); therefore 30 mg/day was defined as the maximum tolerated dose (MTD). Following a single dose of cediranib 10-45 mg/day, the maximum plasma concentration was achieved between 2 and 4 hours post dosing and the overall mean terminal phase half-life was 21 hours. Following multiple dosing there were no time-dependent changes in PK parameters. At the MTD, the unbound minimum plasma concentration was ,5 times above the ...
Group for half-life source : update developers. This mod will include enhanced half-life levels, new training level from PS version of Half-life, new models and more...Credits:Half-life improvement forums for some models, half-life : induction creators...
Maximum concentration (Cmax), time to maximum concentration (tmax), area under the concentration time curve from zero to last observed concentration (AUC0-τ), half-life (t1/2), total body clearance (CL), apparent volume of distribution (VD) in plasma; penetration ratio calculated as CSF concentration (Cmax and AUC0-τ, respectively) divided by plasma ...
OBJECTIVE: To compare pharmacokinetics of eltenac after first and last IV administrations (0.5 mg/kg), using a multiple dosing schedule. ANIMALS: 6 adult mares. PROCEDURE: Eltenac (50 mg/ml) was administered IV at a dosage of 0.5 mg/kg of body weight every 24 hours for days 0 through 4. On days 0 and 4, blood samples were collected before, then periodically for 8 hours after eltanac administration. Concentration of eltenac in plasma samples was determined by use of high-performance liquid chromatography. RESULTS: On day 0, median area under the plasma eltenac concentration versus time curve (AUC) was 6.77 microg.h/ml (range, 5.61 to 8.08 microg.h/ml), median plasma clearance was 1.23 ml/min/kg (range, 1.03 to 1.40 ml/min/kg), and median steady-state volume of distribution was 191 ml/kg (range, 178 to 218 ml/kg). Median terminal half-life of eltenac was 2.36 hours (range, 2.30 to 2.98 hours). On day 4, median eltenac AUC was 6.70 microg.h/ml (range, 5.21 to 7.44 microg.h/ml), median plasma ...
Half Life fans are already concerned that Half Life 3 might then not come first to the PC. Arguments against the Xbox 360 Half Life rumor are the extensive modding community for HL. Microsoft would need to support that to really get existing Half Life players to switch to Xbox 360 ...
Information System >> General Ledger Reports (New) >> Line Items. It is of interest to know the area under the curve, i. For the most common case of drugs which follow linear pharmacokinetics, the area under the curve (AUC) is directly proportional to the amount of drug absorbed. Terminal elimination half-life was 11 hours for salmeterol and 9. The basic unit of the pROC package is the roc function. SAP service entry sheet involves a two-steps process: SAP service entry sheet creation and service acceptance. Journal of Political Economy 114, no. Initially, it was mandated to begin in 2017, but the program has been difficult to operationalize. An open space principally serving AUC JRMC/GAPP students/community through listings of internship/job opportunities and career. Accounting for Disposal of Fixed Assets. The Journal entry will still need to be posted after its created. Jenny and Eugene [two house slaves] were whipped. In this example the net book value is calculated as follows. I have ...
Pharmacokinetic profile with the in vivo recovery of FVIII:C, VWF:RCof, VWF:Ag and VWF:CB, the half-life of VWF:Rcof and VWF:Ag and the apparent half-life of FVIII:C after a single dose of Fanhdi® in pediatric patients with severe VWD ...
Results PRN1008 was safe and well-tolerated in both parts of the study without changes in vital sign, ECG or laboratory measurements. In the MAD, treatment emergent adverse events (AEs) were reported by 50-88% of PRN1008-treated subjects, and 50% of placebo-treated subjects, with mild gastrointestinal AEs more common following PRN1008 vs. placebo. PRN1008 was rapidly cleared with a mean terminal half-life for all doses of approximately 4 hours on day 10. Maximal plasma concentrations ranged from 43 to 630ng/mL, 1-2 hours after dosing on day 1 or day 10. In these same subjects, BTK occupancy ranged from 75±7 to 90±6% (mean ± SD) at four hours on day 1, and 84±4 to 93±2% at four hours on day 10. BTK occupancy declined slowly and persisted at 12 and 24 hours. BTK occupancy at trough (12 or 24 hours) on day 10 ranged from 59±11 to 80±6%, at which time plasma PRN1008 concentrations were negligible. A reduction of basophil activation of up to 73±14.5% (mean ± SD) was observed 4 hours after ...
The creation and maintenance of a collection of compounds with high chemodiversity are also remarkable objectives of this platform, being able to scale up the experiments for massive screening assays (highthroughput screening; HTS) and select the most active compounds against therapeutic targets of interest. Once the compoundis selected, the service provides the means necessary to develop transport systems (polymer conjugates) aiming to improve the solubility of the active compound, increase its half-life time in the bloodstream,to achieve agreater accumulationin the tumor and inflammatory sites,etc.. ...
Desperate people do desperate things, its simply the way of things. When a new 3.7GB update appeared for Half-Life 2 people got excited and immediately...
This program determines half life of radio active elements by using graphs. Half life is defined and the graphs are used to measure the half life of standard
LiamKreptic110d ago Just release it in a way that its like half life but not half life. However the PC community is good at causing havoc if threatened so valve may get screwed if they attempt to disban. (I hope the PC community causes havoc cause valve has never given a clear answer to half life episode 3 and I want a clear answer not the wushu washy crap) ...
Volume of distribution at steady state is termed VDss and is the apparent volume into which a drug will disperse during a prolonged infusion, and is the sum of all compartment volumes in the model ...
Shacknews has posted information regarding Valves plans for Half-Life 2 release which consists on various bundles: The latest HalfLife2.net forum thread has info from Valves Gabe Newell on the three different versions of Half-Life 2 they plan to release. Apparently the…
Theres finally some closure for Half-Life fans, as the series lead writer Marc Laidlaw shares his plot for Half-Life 2: Episode 3.
The defacto tool for previewing Half-Life models is Mete Ciragans Half-Life Model Viewer. However, the current version doesnt support the new texture features of the Half-Life engine. To get around this, Ive modified the source of the v1.25 of the...
Calculation of local dehydration propensities. We introduce a descriptor of hydration tightness for soluble proteins defined as the mean residence time of hydrating molecules within a domain around each residue on the protein surface. The local mean residence time (,τ,i) of hydrating molecules at residue i is defined with respect to a spherical domain D(i) of 6.2-Å radius (approximately the width of three water layers; ref. 10) centered at the α-carbon of residue i. The actual computation of residence times is given in the Supplementary Material. The mean residence times were obtained from classic trajectories generated by molecular dynamic simulations (Supplementary Material).. Backbone exposure for protein targets. The extent of backbone exposure at a particular residue was determined by counting the number of nonpolar side chain groups contained within a 6.2-Å radius sphere (approximately the thickness of three water layers) centered at the α-carbon. The extent of backbone shielding (η) ...
This chapter has a preoccupation with the processes of physics, chemistry and biology. These processes are examined in a way that allows them to be seen as organic algorithms not unlike algorithms used in computer programming. To be honest, I am not totally clear what I see in this relationship, but it is very fertile for growing plot lines.. The second aspect of the chapter deals with time, entanglement and gravity. These are very loosely formed within my mind. Truth be told, I dont think anything lasts in my mind. Everything has a very short half-life within the chaos of my brain. In any event, the readings deal with these concepts. They will come back to haunt the story in later chapters. Also, the third link is...well, not exactly my cup of tea, but it could help in developing a couple of off the wall characters.. Two of the following videos are scientific lessons for ATP and muscle contraction. They are quite dry, but if you think about them in relation to single celled organisms that ...
Any input on how Cytomel is added, when, and what to look for? I see my dr. on Thursday and would like to request the change (Was on desiccated thyroid prior to all this happening...thought I was doing o.k. on it although was getting heart skipping sensations in the afternoon ) Ive read where there is too much T3 compared to T4 in desiccated...that it is 4 times stronger and a very short half-life. My free T4 always seemed very low (way off the chart which would indicate HYPO but my TSH was always really low (.38 ...
Just recently got around to playing the Half Life games and really enjoyed them all. Was wondering if my final battle in the original Half Life was oddly...
How to Survive Through Ravenholm in Half Life 2. Ravenholm is a level in Half Life 2 that is fairly challenging and quite scary. The enemies are all zombies, which makes finding ammo difficult. This is a guide to help get through...
Half life 3?. Think for a sec, maybe Valve is holding back Half life 3 just like episode 2 to make a new orange box. It shall be called: The Potato Box&qu mother fucking h
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TY - JOUR. T1 - Effect of education on the appropriateness of serum drug concentration determination. AU - Carroll, Donna J.. AU - Austin, Garth E.. AU - Austin, Gregory E.. AU - Miyahara, Randell K.. AU - Murphy, John E. AU - Ward, Earl S.. PY - 1992. Y1 - 1992. N2 - The purpose of this study was to document the effect of education on the appropriateness of serum drug concentration (SDC) collection. This study included a period of education for hospital personnel involved in the acquisition of drug levels. These included nursing staff, lab personnel, housestaff (residents/interns), ward clerks, and pharmacists. This study included patients receiving aminoglycoside and/or vancomycin while on the general medicine service during the specified study periods. Patients receiving AB - The purpose of this study was to document the effect of education on the appropriateness of serum drug concentration (SDC) collection. This study included a period of education for hospital personnel involved in the ...
Protein engineering provides powerful tools to create useful proteins with desired properties. In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. FcRn is widely expressed in the human body. The natural ligands of FcRn are immunoglobulin G (IgG) and serum albumin (SA). FcRn can bind to both proteins in a pH dependent manner and endow them with an unusually long half-life in vivo. Protein building blocks interacting directly or indirectly with FcRn may potentially be used to either piggy-back on the FcRn-system for extension of the in vivo half-life or to saturate the system to decrease the in vivo half-life of the natural ligands. In this thesis, I have explored an FcRn binding affibody molecule (ZFcRn) and/or an albumin binding domain (ABD) for these purposes. In study I and II, the prolactin receptor was found to often be expressed in glioblastoma multiforme ...
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical Tributylmethylammonium chloride (CAS no. 56375 -79 -2). The studies are as mentioned below: The half-life of the test chemical was determined at different pH range. The study was performed at pH of 4, 7 and 9, & at a temperature of 20°C, respectively. The half-life period of test chemical was determined to be ≥ 1 yr at pH 4, 7 and 9, respectively & at a temperature of 20°C and thus test chemical was reported to be hydrolytically stable. On the basis of this, test chemical is considered to be not hydrolysable. In an another study, the half-life of the test chemical was determined.The half-life value of test chemical was determined to be ranges from 5 to 63 days, respectively. Thus, based on the value, test chemical is considered to undergoe slow to negligible hydrolysis in water. For the test chemical, the hydrolysis half-life value was ...
The clinical pharmacokinetics of etoposide were studied in eight pediatric patients with refractory solid tumors. The α-phase half-life, β-phase half-life, volume of distribution, and elimination rate constant averaged 0.82 hr, 6.5 hr, 4.0 liters/sq m, and 0.25 hr-1, respectively. Noncompartmental parameters such as systemic clearance, mean residence time, and volume of distribution at steady-state averaged 20.9 ml/min/sq m, 7.8 hr, and 7.2 liters/sq m, respectively. A significant relationship between serum glutamic pyruvic transaminase and systemic clearance was observed, with patients having elevated serum glutamic pyruvic transaminase showing slower systemic clearance of etoposide. Systemic clearance, mean residence time, and β-phase half-life of etoposide were significantly lower in those patients who had received cisplatin prior to their Phase II etoposide trial. The average pharmacokinetic values derived from these eight pediatric patients with solid tumors did not differ significantly ...
This pharmacokinetic study of nivolumab showed that there is little ethnic difference in the handling of nivolumab.Nivolumab was well tolerated in Korean patients.Background.This phase I study of nivolumab, an anti‐programmed cell death‐1 (anti‐PD‐1) monoclonal antibody, investigated the pharmacokinetics and safety of nivolumab in Korean patients with advanced solid tumors. Findings were compared with results from Japan and the U.S.Materials and Methods.In this two‐part study, patients received a single dose of nivolumab (1, 3, and 10 mg/kg; ONO‐4538‐13) and were followed up for 3 weeks. Those who met the required criteria proceeded to the second part (ONO‐4538‐14), and received the same dose as in part one every 2 weeks.Results.Six patients per dose level were enrolled (n = 18). The mean elimination half‐life of nivolumab among the groups ranged from 15.0 to 19.1 days. The maximum serum concentration and area under serum concentration-time curve increased almost ...
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Pathologic hyperpermeability exists in the spectrum of disease states, including neuro-ischemic, neuro-inflammatory and neuro-oncological. To-date the characterization of disease pathology with T 1 -weighted quantitative dynamic contrast-enhanced magnetic resonance imaging has relied on the study of modeled microvascular parameters such as diseased tissue transvascular flow rates of small molecule paramagnetic imaging agents with short plasma half-lives, based on which it is difficult to assess the specific nature of the disease state. Another type of T 1 -weighted quantitative dynamic contrast-enhanced magnetic resonance imaging involves the use of paramagnetic heavy metal-chelated dendrimer nanoparticles that possess longer plasma half-lives with pre-determined molar relaxivities to quantitatively image concentration of macromolecular contrast agent accumulation over time in hyperpermeable pathology such as solid tumor tissue with the
Postoperative nausea and vomiting (PONV) remains a common complication for both inpatients and outpatients undergoing surgical procedures. PONV is a complex physiologic phenomenon involving multiple neurophysiologic pathways and both central and peripheral receptor mechanisms. The frequently used antiemetics produce dopamine, acetylcholine, histamine, and serotonin receptor blocking properties.1 More recently, the neurokinin (NK)-1 receptor antagonists were also shown to have the potential for both preventing and treating PONV.2 - 7 In this issue of Anesthesia & Analgesia, Gan et al.8 report on rolapitant, a novel NK-1 receptor antagonist with a long elimination half-life value, for the prevention of PONV. This clinical trial was designed as a dose-ranging study involving both placebo and active comparator controls. The authors concluded that rolapitant reduced the incidence of postoperative vomiting in a dose-dependent manner and was superior to placebo at all doses studied. They also noted ...
If an alien visited Earth and wanted to capture a summary of video gaming, theyd quickly become aware of Half-Life. The series is far from foreign to the hearts of most gamers, and the products of the Half-Life universe - both the Half-Life and Portal series - remain some of the highest rated games by critics. However, the series has become even more iconic for its unreleased sequel, Half-Life 3.. Half-Life 3, or perhaps more appropriately Half-Life 2: Episode Three, has become a notable case of anticipation and speculation. Years after the latest instalment to the Half-Life series, the game is yet to even get a mention by developer Valve, even though the episodic sequels to Half-Life 2 were announced as a triology. In this article, well take a look at the story of Half-Life, both in the games released already and whats speculated for the future.. Be warned: spoilers ahead! (more…). ...
Distribution: Following drug administration, a 6 to 8 hour tissue distribution phase is observed. This is followed by a much more gradual decline in the serum concentration of the drug, which is dependent on the elimination of digoxin from the body. The peak height and slope of the early portion (absorption/distribution phases) of the serum concentration-time curve are dependent upon the route of administration and the absorption characteristics of the formulation. Clinical evidence indicates that the early high serum concentrations do not reflect the concentration of digoxin at its site of action, but that with chronic use, the steady-state post-distribution serum concentrations are in equilibrium with tissue concentrations and correlate with pharmacologic effects. In individual patients, these post-distribution serum concentrations may be useful in evaluating therapeutic and toxic effects. Digoxin is concentrated in tissues and therefore has a large apparent volume of distribution ...
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Hydrolysis Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below: The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C (ranges from 49-51°C) and pH of 4, 7 and 9, respectively. Initial test chemical concentration used for the study was 100 mg/l. Experiment was performed in 2 replicates. The test substance has no activity of hydrolysis and thus was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of50⁰C for 5 days. The half-life value of test chemical was determined to be , 5 days at pH 4, 7 and 9, respectively & at a temperature of 50⁰C. Thus based on this, test chemical is considered to be not hydrolysable. In an another study, the half-life and hydrolysis rate constant was determined of the ...
Radioactivity is generally used in life sciences for highly sensitive and direct measurements of biological phenomena, and for visualizing the location of biomolecules radiolabelled with a radioisotope. All atoms exist as stable or unstable isotopes and the latter decay at a given half-life ranging from attoseconds to billions of years; radioisotopes useful to biological and experimental systems have half-lives ranging from minutes to months. In the case of the hydrogen isotope tritium (half-life = 12.3 years) and carbon-14 (half-life = 5,730 years), these isotopes derive their importance from all organic life containing hydrogen and carbon and therefore can be used to study countless living processes, reactions, and phenomena. Most short lived isotopes are produced in cyclotrons, linear particle accelerators, or nuclear reactors and their relatively short half-lives give them high maximum theoretical specific activities which is useful for detection in biological systems. Radiolabeling is a ...
Buy Ractopamine is an animal growth promotant. The effects of the beta-agonist ractopamine, use in finishing swine and cattle to improve carcass quality and performance. Moreover Feeding RAC to late-finishing swine resultes in faster growing, more efficient animals with increased boneless subprimal yields, and it had little effect on pork juiciness and flavor.. Also Ractopamine is rapid in intake, with the mean peak plasma concentration of 41.2 ng/ml occurring after an average of 0.6 h. Ractopamine is extensively and rapidly enters, with an oral bioavailability of a minimum of 45.7% of the dose. Owing to rapid metabolism, the oral dose of 40mg produce low systemic concentrations of parent ractopamine, suggesting significant first-pass metabolism of the drug.. Molecular Formular: C18H23NO3. IUPAC Name: 4-(1-Hydroxy-2-{[4 ...
In a hydrolysis study conducted by Ricerca Inc. (BAMM 1990), the half-life of 14C-butyl acrylate in water at pH 11 was determined to be approximately 243 minutes. There was less than 2 % hydrolysis of 14C-butyl acrylate at pH 3 and pH 7 during the 28 day period. Approximate hydrolysis half-life values for pH 3 and pH 7, calculated using initial and final 14C-butyl acrylate concentrations, were 2800 days at pH 3 and 1100 days at pH 7. Therefore, the substance will hydrolyse slowly in contact with water under environmental conditions. Hydrolysis will not contribute significantly to the degradation of n-butyl acrylate under environmental conditions. ...
The mean oral absolute online bioavailability of sales the maxalt retinal detachment symptoms Tablet is retin about online 45, and how to get retin a retin mean peak plasma concentrations (Cmax) are reached in sales approximately 1-1.5 hours (Tmax). Diagnosis Your health care provider may check the size of sales your sales prostate gland directly by putting a sales gloved finger in your rectum and feeling the back wall of the prostate. You can retin ask your pharmacist or sales doctor for information about maxalt that is written for health professionals. Have shortness of breath or chest pain. If there is evidence of CAD or coronary artery vasospasm, maxalt should not be retin administered see contraindications. This medication may be available under multiple brand names and/or in several different forms. You can place the order online, by mail, online by fax or toll-free over the telephone. Your health care provider will also order blood tests, and possibly a sales urine sample. Free Make Up ...
You could expect a dose or prednisone to be out of your system in 16.5 to 22 hours. The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half. It usually takes around 5.5 half lives for a drug to be completely eliminated from your system. ...
You could expect a dose or prednisone to be out of your system in 16.5 to 22 hours. The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half. It usually takes around 5.5 half lives for a drug to be completely eliminated from your system ...
You could expect a dose or prednisone to be out of your system in 16.5 to 22 hours. The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half. It usually takes around 5.5 half lives for a drug to be completely eliminated from your system ...
You could expect a dose or prednisone to be out of your system in 16.5 to 22 hours. The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half. It usually takes around 5.5 half lives for a drug to be completely eliminated from your system. ...
You could expect a dose or prednisone to be out of your system in 16.5 to 22 hours. The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half. It usually takes around 5.5 half lives for a drug to be completely eliminated from your system. ...
Fig. 4. Mode of inhibition against PHD3 (left) where GSK1278863 IC50 values were plotted as a function of [α-KG]/Kmapp and fit to an equation for competitive inhibition. Determination of the dissociation half-life value (t1/2) for GSK1278863 from PHD3 by rapid dilution method (right). The yellow squares show the enzyme activity after dilution fit to an equation to determine the observed rate of recovery (kobs). Control reactions at 10x IC50 (black circles) and 0.1x IC50 (white squares) represent enzyme activity before dilution and after dilution if the compound was rapidly reversible. ...
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We report on extensive experimental studies on thin film, single crystal, and ceramics of multiferroic bismuth ferrite BiFeO3 using differential thermal analysis, high-temperature polarized light microscopy, high-temperature and polarized Raman spectroscopy, high-temperature x-ray diffraction, dc conductivity, optical absorption and reflectivity, and domain imaging, and show that epitaxial (001) thin films of BiFeO3 are clearly monoclinic at room temperature, in agreement with recent synchrotron studies but in disagreement with all other earlier reported results. We report an orthorhombic order-disorder beta phase between 820 and 925 (±5) °C, and establish the existence range of the cubic gamma phase between 925 (±5) and 933 (±5) °C, contrary to all recent reports. We also report the refined Bi2O3-Fe2O3 phase diagram. The phase transition sequence rhombohedral-orthorhombic-cubic in bulk [monoclinic-orthorhombic-cubic in (001)BiFeO3 thin film] differs distinctly from that of BaTiO3. The ...
SIBELIUM is a selective calcium antagonist. It prevents cellular calcium overload by reducing excessive transmembrane calcium influxes. Flunarizine is well absorbed from the gut, reaching peak plasma levels within 2 - 4 hours and reaching steady state at 5 - 6 weeks. After extensive hepatic metabolism, flunarizine and its metabolites are excreted through the faeces via the bile. The mean terminal elimination half-life is about 18 days. Plasma protein binding is 99 ...
These are not all of the side effects diltia may occur, diltia xt. If diltia are being treated diltia high blood pressure, keep filtia this medicine even if you feel well. Kidney failure, pyelonephritis, urinary tract infection. This medication may be prescribed for other uses. We comply with the HONcode standard for trustworthy health information - verify here. Administer inotropic agents dopamine or dobutamine and diuretics. Each diltiazem product has different instructions for whether or not it should be taken with or without food, so ask your pharmacist for more information. Other Requirements Back to Top. In the intact animal, prolongation of the AH interval can be seen at higher doses. Available for Android and iOS devices. Similar findings were observed for standing systolic and diastolic blood pressures. The plasma elimination half-life of diltiazem is approximately 3. The dose your doctor recommends may be based on the following: Available for Android and iOS djltia. In exercise ...
The half-life of knowledge or half-life of facts is the amount of time that has to elapse before half of the knowledge or facts in a particular area is superseded or shown to be untrue. These coined terms belong to the field of quantitative analysis of science known as scientometrics. These ideas of half-life applied to different fields differ from the concept of half-life in physics in that there is no guarantee that the knowledge or facts in areas of study are declining exponentially. It is unclear that there is any way to establish what constitutes knowledge in a particular area, as opposed to mere opinion or theory. An engineering degree went from having a half life of 35 years in ca. 1930 to about 10 years in 1960.[1] A Delphi Poll showed that the half life of psychology as measured in 2016 ranged from 3.3 to 19 years depending on the specialty, with an average of a little over 7 years.[2] It has also been used in Christian missiology to increase the effectiveness of their teachings.[3] ...
GHRH (growth hormone releasing hormone) is produced in the hypothalamus. Its pulsatile release from the hypothalamus triggers a pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life = the time required to remove half of the substance from the blood. The shorter the half- life, the more rapidly the substance is removed from the body, and the less its effect on the body). The first 29 amino acids of GHRH is the active segment. They are available as a manufactured peptide called Sermorelin. Sermorelin was further modified to increase its half-life to 30 minutes. This is called CJC 1295. CJC-1295 was further modified by adding DAC (Drug Affinity Complex) to it. DAC binds to a blood protein called albumin, which increases its half-life to 8 days. It is called CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form which mimics a more normal physiologic GH spike each night. The longer half-life from the DAC binding to albumin means ...
A half life of a substance is the amount of time it takes to decay into half of its activity. Usually, this refers to the bodys getting rid of a substance. This happens by the function of kidneys and liver as well as excretion. ...
The most frequently reported adverse events (AEs) were dermatitis contact, back pain, blood pressure decrease, headache and nausea. The majority of AEs were mild in intensity with few moderates and no severe. No increase in AEs was observed in relation to increasing dose. The PK analysis indicated that the AUC and Cmax increase in a more than dose proportional manner over the 25 to 600 mg doses with the AUC and Cmax at 600 mg being respectively 62- and 92-fold higher than at the 25 mg dose. Proportionality in AUC and Cmax was noticed between the 600 and 800 mg doses. The elimination half-life, for all cohorts, was ca. 5 hours. At the 400 mg dose, there was no significant food-effect on any of the measured PK parameters. There was a ritonavir-effect as the PK parameters for terminal half-life, AUC and Cmax were 3-, 19- and 6-fold higher, respectively, when 25 mg VCH-286 was co-administered with 100 mg ritonavir. This observation is consistent with the fact that VCH-286 is a CYP3A4 substrate. ...
To the editor: The paper on naloxone by Dr. Martin (Ann Intern Med 85:765-768, 1976) states on page 767, Naloxone has a relatively short duration of action. The serum half-life of naloxone is just over an hour (17) and the half-life of commonly used clinical doses may be only several hours (18, 19).. By definition, the half-life of any substance X is constant and most certainly does not depend on the initial dose. This is such a serious conceptual error that it undermines my confidence in the whole paper. ...
Clinical Pharmacokinetic Characteristics of Cebranopadol, a Novel First-in-Class Analgesic. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
The most common price range of Cialis falls between $5 per pill for lower doses (2.5 mg and 5 mg) and $20 to $30 per pill for higher doses (10 mg and 20 mg).. Most doctors prescribe Cialis at a typical strength of 10 mg daily. Now, a bottle of 30 pills with 10 mg Cialis approximately costs $650 to $1,800, depending on where you buy it.. Cialis does cost significantly higher compared to its counterparts. Viagra costs up to $1,400 or less per bottle, while Levitra is around $500 per bottle.. Cialis belongs to the same drug family as Viagra and Levitra. It works just the same as those two, and all of them are equally effective in treating erectile dysfunction.. So, why is it that Cialis is such a pricey drug compared to them?. ...
CONCEPTS IN CLINICAL PHARMACOKINETICS DIPIRO PDF - Concepts in Clinical Pharmacokinetics, 5th Edition: Medicine D. Dr. Joseph T. DiPiro is Executive Dean of the South Carolina College of. Concepts in
Fazadinium was administered as an intravenous bolus of 0.5 or 1 mg/kg to nine patients during neurolept-anaesthesia. Continuous recording of neuromuscular activity and serial collection of blood samples for drug assay allowed the relationship between neuromuscular blockade and plasma fazadinium concentration to be studied. Pharmacokinetic analysis demonstrated high plasma clearances (221 and 185 ml/min), and short terminal half-lives, (30 and 50 min), for the two doses of the drug. Mean plasma concentrations at 10 and 50% recovery were 1.42 and 0.88 micrograms/ml respectively, demonstrating that the potency of fazadinium is approximately half that of tubocurarine and one eighth that of pancuronium. In addition, the relationship between plasma concentration and depression of neuromuscular activity during spontaneous recovery from the relaxant is described.
I hope you dont me saying I think you have it wrong with the knowledge economy. David mentioned the singularity - I dont think the knowledge economy can take us that far. You see there is a fundamental limit, the capacity of the human brain. To train an expert takes an ever increasing time, and his expertise has an ever decreasing half-life. We need to leverage the human capacity for understanding enormously or humanity will be overwhelmed by its own knowledge. We already are talking of a web that is data rich and information poor. There is a great danger of that situation becoming worse, of attention and understanding becoming absolute limiting factors. Im not convinced that the knowledge worker is the owner of the future, Ive already had to reinvent myself often enough, thanks. (And do you know how soul destroying it is to create useful niche interfaces with short half-lives - that get replaced eventually with something cheaper and far better?) We need a world that humans can find a ...
Clonazepam is absorbed from the proximal small intestine. It is extensively distributed in the body.It is 85 % bound to plasma proteins.Plasma half life averages 24 hours.It is metabolised in the liver. Clearance is reduced in liver damage.It is excreted in urine.
Community Download is a weekly discussion-focused articles series published (usually) every Monday in which we pose a single, core question to you all, our readers, in the spirit of fostering discussion and debate. For todays Community Download, we want to know if you think Half-Life: Alyx is the best VR game ever made. Why or why not?. Half-Life: Alyx [read our review] is out and its real. After many, many long years Valve has finally released a new Half-Life game. Even though you dont play as Gordon Freeman and instead take on the role of Alyx Vance, its as crucial to the franchises overall storyline as any other entry and is packed full of amazing moments.. Valve is one of the companies most involved with the early days of consumer VR that we find ourselves in right now. From influencing Palmer Luckey on his journey to co-found Oculus, establishing their own tracking system in the SteamVR lighthouse base stations, co-producing the HTC Vive, releasing The Lab, creating the Valve Index, ...
Action, Adventure, Free to Play, Indie - Released: Dec 3, 2013. Half-Life: Before - is a modification for Half-Life with new levels and story. Mod is based on Spirit of Half-Life 1.8 technology, that increases visual and functional component of the mod.Youre playing as a Black Mesa scientist Andrew Winner. ...
Half-Life 2 er solgt i over 4 millioner eksemplarer på verdensplan og har vundet over 35 priser for årets spil. Episode One er det første i en serie af spil, som afslører historien efter Half-Life 2 og indleder rejsen efter City 17. Indeholder også to multiplayer-spil. Half-Life 2 er ikke påkrævet.
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"Half-Life". G4TV.com. Archived from the original on March 6, 2005. "Bungie". G4TV.com. Archived from the original on March 6, ...
Jackson's first novel, Half Life, was published by HarperCollins in 2006. The story of a disenchanted conjoined twin named Nora ... "half life". www.ineradicablestain.com. Braiker, Brian. "Two Times a Lady", Newsweek, August 16, 2006. Retrieved 2007-08-01. " ... ISBN 978-0-385-72120-2. Shelley Jackson (2006-07-25). Half Life: A Novel. HarperCollins. ISBN 978-0-06-088235-8. Shelley ... Half Life went on to win the 2006 James Tiptree, Jr. Award for science fiction and fantasy. In 1987, Jackson married the writer ...
Half Life took place at Kilmartin Glen, Argyll from 4-16 September 2007, and was a collaboration between NVA and the National ... Half Life. Documentation of event on NVA website. Retrieved 3 March 2008. White Bike Plan. Documentation of event on NVA ... These works included The Secret Sign, The Path, The Storr and Half Life. The works were designed to involve local communities ... Half Life (2007) Spirit (2008) White Bike Plan (2010) Glasgow Harvest (2010) Speed of Light (2012) Hinterland (2016) About NVA ...
1998 saw many sequels and prequels in video games and several new titles such as Half-Life, Metal Gear Solid, F-Zero X, The ... "Half-Life". GameSpot. Retrieved February 24, 2019. "What's Up?: Wesolych Swiat" (PDF). PC Games (in German). No. 76. January ... Kent, Steven L. (2001). The Ultimate History of Video Games: The Story Behind the Craze that Touched our Lives and Changed the ... Kent, Steven L. (2001). The Ultimate History of Video Games: The Story Behind the Craze that Touched our Lives and Changed the ...
Half-length; life size. She sits, inclined to the left, looking out of the picture. Over her bright black gown she wears a cape ... Sylvius, half-length, in black costume and a cap and collar on Christie's website Saskia van Uylenburgh in the 1001 Vrouwen uit ...
Half-Life. "The Escapist : Video Galleries : Zero Punctuation : Half-Life". Escapistmagazine.com. Retrieved 6 November 2012. " ... "Yahtzee Croshaw on Mogworld (again)". Half-Life (7 March 2018). "Fully Ramblomatic - the blog of Yahtzee Croshaw: Differently ... August 2019: The Life of Erich Zann - a horror game inspired by the short story The Music of Erich Zann by H.P. Lovecraft. ... Yahtzee has since openly disowned his comics, attributing it to a "dark time" in his life, although they are still hosted ...
Half-length ; life size. A youth, turned three-quarters right, looks at the spectator. On his long curls he wears a black felt ...
Half-length ; life size. She stands, inclined to the left, and looks at the spectator. She holds her fan in her left hand, ...
"Half life". Drug Bank. Retrieved 15 July 2011. Knauf PA, Mann NA (May 1984). "Use of niflumic acid to determine the nature of ...
Half-length ; life size. A fisher-boy, seen in full face, laughs at the spectator. His arms are folded on his breast. He wears ...
Half-Life 2's] gravity gun for best video game weapon ever". In an article published on their Planet Half-Life website on the ... Soon after the release of Half-Life 2, Valve released a software development kit (SDK) for the game's Source engine. The SDK ... the creation of new maps to the creation of an entirely different game based on the coding framework of Half-Life 2, known as ... Planet Half-Life. IGN. Archived from the original on 2011-07-11. Retrieved 2008-02-28. CS1 maint: discouraged parameter (link ...
Half-Life multiplayer CS model) HK G36 Model (Half-Life multiplayer CS model) HK PDW Model (Half-Life multiplayer CS model) M16 ... 1999: USS Darkstar (Half-Life single player mod for PC Gamer) Feb. 2000: They Hunger (Half-Life single player mod for PC Gamer ... 2000: They Hunger 2: Rest in Pieces (Half-Life single player mod for PC Gamer) Nov. 2000: Vidar's Niflheim (Half-Life ... 2001: They Hunger 3: Rude Awakening (Half-Life single player mod for PC Gamer) Sep. 2003: Underworld: Bloodline (Half-Life ...
Half-length; life size. He stands in profile to the right, turning his head and eyes to the spectator. He has thick curly hair ... The self-portrait shows Rembrandt at half length facing towards the right, wearing a velvet cape decorated with gold embroidery ...
The Orange Box also contains Half-Life 2, Half-Life 2: Episode One, Half-Life 2: Episode Two, and Portal. Valve offered The ... as a free Half-Life mod. Team Fortress Classic was developed using the publicly available Half-Life software development kit as ... "Half-Life 2: Episode Two - The Return of Team Fortress 2 and Other Surprises". GameSpot. July 13, 2006. Archived from the ... Walker and Cook worked on various other Valve projects; Walker was project lead on Half-Life 2: Episode One and Cook worked on ...
After the break-up of the duo he made several albums for adults, echoing the communist times (i.e. Half-life, March). In the ...
The half life is long, around 30 years. It can take hundreds of years to decay to negligible levels. Exposure from contaminated ... The biological half-life of strontium-90 in humans has variously been reported as from 14 to 600 days, 1000 days, 18 years, 30 ... 90Sr undergoes β− decay with a half-life of 28.79 years and a decay energy of 0.546 MeV distributed to an electron, an ... Strontium-90 (90 Sr ) is a radioactive isotope of strontium produced by nuclear fission, with a half-life of 28.8 years. It ...
"Half-Life enemies". GameSpy. IGN Entertainment. Archived from the original on 10 April 2010. Retrieved 11 October 2013. " ... such as Half-Life (1998) and American McGee's Alice (2000) A song, "Nine Funerals of the Citizen King", by Henry Cow. Various ... The pig who deserts its sty represents the suicidal person who abandons life. (Like the pig, he's guilty - but being dead, is ... Two explanations of which event in Carroll's life gave rise to The Hunting of the Snark have been offered. Biographer Morton N ...
... used in Half-Life) as a way of promoting Half-Life's software development kit. Since the release of Team Fortress Classic, the ... Running up to Half-Life 2's release in 2004, Valve's Doug Lombardi claimed that Team Fortress 2 was still being developed and ... On June 9, 2000, Team Fortress version 1.5 was released a part of Half-Life's 1.1 update. It was the first standalone version ... "Half-Life v1.1 now available". Eurogamer. Retrieved May 30, 2018. "TCF Info". ShackNews. Retrieved May 30, 2018. "Team Fortress ...
The biological half-life of caesium is about 70 days. A 1961 experiment showed that mice dosed with 21.5 μCi/g had a 50% ... Metastable barium has a half-life of about 153 seconds, and is responsible for all of the gamma ray emissions in samples of ... Caesium-137 has a half-life of about 30.17 years. About 94.6% decays by beta emission to a metastable nuclear isomer of barium ... "Biological Half-life". Hyperphysics. Moskalev, Yu. I. (1961). "Biological Effects of Cesium-137". In Lebedinskiĭ, A. V.; ...
"Casey's "Half Life"". The Minneapolis Star Tribune. May 10, 1998. Loft McNight Fiction Fellowship, Minnesota, 1984 (judge: ... He lives in Medicine Lake, Minnesota. The short storywriter and essayist William Kittredge said of Lacy's work, The Natural ... The Natural Father is that good thing, a book that both sweetens and illuminates our lives." Of Happy Birthday, Dear Darrell, ...
G4tv (November 16, 2004). Icons: Half-Life. Event occurs at 2:20. Staff (November 30, 2004). "Valve wins round one in Half-Life ... "Half-Life's Final Boss Was Based On Gabe Newell's Son (Being Born)". Kotaku. Retrieved August 11, 2018. Ingham, Tim (April 4, ... This was accompanied by VR stands for Valve games such as Half-Life: Alyx and The Lab. The event was postponed from August to ... The birth of Gray in the late 1990s served as inspiration for the final boss of Half-Life, as the couple considered childbirth ...
CS1 maint: discouraged parameter (link) Kim, Matt (21 November 2019). "Half-Life: Alyx Is 'About the Same Length as Half-Life 2 ... best known for co-developing Quake Team Fortress, Team Fortress Classic, Team Fortress 2, and Half-Life: Alyx. He went to RMIT ... Walker worked on Valve's flagship virtual reality game, Half-Life: Alyx, released on March 23, 2020. Walker has started to use ... Dodson, Joe (13 October 2007). "By Design - Half-Life 2: Orange Box". GameSpot. Retrieved 16 December 2014. CS1 maint: ...
Planet Half-Life called the gravity gun "the next level in interactive gaming." Electronic Gaming Monthly described Half-Life ... McWhertor, Michael (November 21, 2019). "Half-Life: Alyx is Valve's VR-exclusive, full-length prequel to Half-Life 2". Polygon ... Valve's 2020 virtual reality game Half-Life: Alyx is set as a prequel to Half-Life 2. The player controls Alyx Vance who during ... Half-Life 2 (PC). Level/area: Black Mesa East. Alyx Vance: Its designed for handling hazardous materials, but we mainly use it ...
The plot and settings of Minerva are linked to Someplace Else, Foster's original map for Half-Life, and to Half-Life 2 itself. ... Half-Life 2 Minerva mod, PC Zone Staff, Computer and Video Games, August 8, 2006, accessed October 3, 2007 "A new life awaits ... In contrast to Half-Life 2, no non-hostile characters or dialogue ever appear; instead, the player is aided by a mysterious ... Minerva takes place in the Half-Life universe. Part of the first level is played in and around a World War II bunker, placed in ...
But 90Sr has a 30-year half-life, and 89Sr a 50.5-day half-life. Thus in the 50.5 days it takes half the 89Sr atoms to decay, ... The physical or nuclear half-life of 137Cs is about 30 years. Caesium in humans normally has a biological half-life of between ... The prussian blue reduces the biological half-life (different from the nuclear half-life) of the caesium. ... the last one or two decays may have a long half-life and release less energy. Fission products have half-lives of 90 years ( ...
The half life is long, around 30 years, and is classified as high-level waste. It can take hundreds of years to decay to ... While 90Sr (half-life 28.90 years) has been used similarly, it is also an isotope of concern in fallout from nuclear weapons ... The biological half-life of strontium in humans has variously been reported as from 14 to 600 days, 1,000 days, 18 years, 30 ... The former has a half-life of 50.6 days and is used to treat bone cancer due to strontium's chemical similarity and hence ...
"Empires - Planet Half-Life". Archived from the original on December 18, 2007. "Empires 1.06 - Planet Half-Life". Archived from ... Coastline to Atmosphere - A mod set in the Half-Life 2 universe, following Gordon Freeman after the events of Half-Life 2. Dear ... Meer, Alex (2013-01-07). "Half-Life 2 Walks The Dinosaur: Jurassic Life". Rock Paper Shotgun. Archived from the original on ... NeoTokyo is a Half-Life 2 mod which puts the player into a future Tokyo universe inspired by anime such as Akira and Ghost in ...
Half-length ; life size. She sits in an arm-chair, inclined to the left, and looks in that direction. Her elbows rest on the ... It is inscribed with her age of 87, which indicates a long and therefore privileged life. Her wealth is further emphasized by ... half length, ca. 1640 of later in the RKD. ...
The mod is freely available to anyone who has purchased a Source-based game, such as Half-Life 2 or Portal. The current status ... CS1 maint: discouraged parameter (link) Rogers, Thomas (2008-08-09). "Jailbreak: Source 0.4". Planet Half-Life. IGN. Archived ... "this could be one of the best of the best multiplayer experiences in the crowded Half-Life 2 modding scene". Jailbreak: Source ... In an article published by the Planet Half-Life website on the GameSpy network, IGN, staff writer Thomas "Editor321" Rogers ...
It also comes packaged with Half-Life 2: Deathmatch, Peggle Extreme, and Half-Life 2: Lost Coast. The demo includes test ... they decided to tie the game to an existing franchise-Half-Life-to allow them to reuse the Half-Life 2 art assets. Wolpaw and ... chronologically taking place after Half-Life and before Half-Life 2, had occurred before Portal 2's events. The areas of the ... During its development, Half-Life 2: Episode Two featured a chapter set on Aperture Science's icebreaker ship Borealis, but ...
Prednisolone Liquid Half Life. We Provide Maximum Privacy Protection Whilst You Order. Save On Discount Prescription Drugs From ... cerebrovascular patients and drafting of prednisolone liquid half life the dietary.. Upon sponge, half the glucocorticoid- ... If you are prednisolone liquid half life taking this acetate once a decrease, take it in the diagnosis. He is a activity and a ... This ketal is a dose of my effects: medical  after that i went to prednisolone liquid half life my fatigue and pharmacy messed ...
... the second half-life is from 50% to 25%, and so on. A biological half-life or elimination half-life is the time it takes for a ... "first half-life", "second half-life", etc., where the first half-life is defined as the time required for decay from the ... Instead, the half-life is defined in terms of probability: "Half-life is the time required for exactly half of the entities to ... The biological half-life of caesium in human beings is between one and four months. The concept of a half-life has also been ...
The longer half-life is called the terminal half-life and the half-life of the largest component is called the dominant half- ... The half-life for this process is[16] t. 1. 2. =. ln. ⁡. 2. k. .. {\displaystyle t_{\frac {1}{2}}={\frac {\ln 2}{k}}.\,}. Half- ... Peripheral half-life[edit]. Some substances may have different half-lives in different parts of the body. For example, oxytocin ... half-life may also describe the time it takes for the blood plasma concentration of a substance to halve (plasma half-life) its ...
... half-life of the radionuclide, the two act as parallel paths for elimination of the radioactivity, the effective half-life ... Biological Half-life Biological Effects of Radiation ©1996, Kenneth R. Koehler. Half-life, effective, European Nuclear Society ... An effective half-life of the drug will involve a decay constant that represents the sum of the biological and physical decay ... It reflects the cumulative effect of the individual half-lives, as observed by the changes in the actual serum concentration of ...
Half-Life was published to critical acclaim by Alyson Books in 2004. Of Half-Life, Reed Business Information wrote "Gay readers ... Half-Life is a debut novel by Aaron Krach. Published in 2004 by Alyson Books, the novel was nominated for a Violet Quill Award ... Krach, Aaron (2004). Half-life: a novel. Alyson Books. ISBN 1-55583-854-5. OCLC 53971973. Retrieved October 26, 2009. Alyson ... Many of the familiar landmarks will remain-his best friend Dart riding shotgun; the suburban house where he lives with his dad ...
See screenshots of Half-Life: Browse dozens of high resolution images, screenshots, wallpapers, pictures, artwork, and more on ...
Thats one of the reasons that Sierra almost brought Half-Life to Dreamcast, and why it carried through with Half-Life on ... Needless to say, Half-Life was, and still is, a brilliant game from head to toe. ... Along with the original Half-Life, Gearbox also has added in the exclusive mode Decay, a two-player cooperative mode that ... which created Half-Life: Opposing Forces) went out of its way to stuff more modes of play and extras than any of the PC games ...
... The radioactive half-life for a given radioisotope is the time for half the radioactive nuclei in any ... The radioactive half-life gives a pattern of reduction to half in any successive half-life period. ... After two half-lives, there will be one fourth the original sample, after three half-lives one eight the original sample, and ...
One half-life is the time required for one half of any given quantity of the substance to decay. For example, the half-life of ... half-life half-life. half-life, measure of the average lifetime of a radioactive substance (see radioactivity ) or an unstable ... One half-life is the time required for one half of any given quantity of the substance to decay. For example, the half-life of ... 2 half-lives), 12.5 grams after 24 minutes (3 half-lives), and so on. Of course the 87.5 grams that are no longer present as ...
Half-Life: Opposing Force - This is the official game expansion for Half-Life. In Opposing Force, players return to the Black ... Half-Life: Counter-Strike - This is a team-based MOD, and casts players in the role of terrorist or counter-terrorist. Each ... Throughout the game, both friends and foes behave in sophisticated and unpredictable ways, a result of Half-Lifes powerful and ...
There are a wide variety of ways to create images that have been made accessible to people over the past year or two. The 3D videography of Dot or the filtration-driven iPhone apps for example. Cinegram is just another of these. And more are on the way even as I write this.. For the past ten years "new" media has, to be quite honest, simply been a tale of new distribution. There wasnt anything new about the media at all. It was still images, text and eventually video; it was all just mixed media. The "new" thing was that it was delivered via a new device (the computer) by new companies that were not newspaper publishers, television broadcasters, film studios or radio stations. That was the "new" in new media.. As we start to encounter and play with actually "new" media like cinegram or Dot, we gain the opportunity to craft new narratives. Just as the haiku poetry format doesnt fit all narratives, not all narratives will be best served by emerging new media formats.. But some people will play ...
... is the time required for one-half of the total amount of a particular substance in a biological system to be... ... Biological half-life (represented as t 1/2) is the time required for one-half of the total amount of a particular substance in ... Toxic chemicals with a long biological half-life (such as some pesticides) will tend to accumulate in the body and are, ... A substance with a short biological half-life may still accumulate if a portion of it it becomes tightly bound to bone or other ...
Half-Life 2 meets Hotline Miami in this free mashup called Half-Line Miami You probably already saw this Half-Life 2 and ... Half-life 2 Valve will let fans sell 3D-printed merch for Dota 2, CS: GO, Portal, Half-Life, and Team Fortress 2 If you thought ... Half-life 2 headlines. * Half-Life 2: Aftermath is a mod which combines content from Episode 3 leaks and prototypes A project ... Half-Life 2 and the rest of The Orange Box comes to Xbox One via backwards compatibility Xbox One users can now play Half-Life ...
Half Life. By Chris Suellentrop July 2, 2007 5:14 pm. July 2, 2007 5:14 pm ... Private Lives Fractured: A First Date It wasnt my heart that he broke.Read more… ...
Did you know theres an official slice of the Half-Life saga that never found its way to PC? Decay was a bonus game mode in the ... Playstation 2 port of the first Half-Life, much as Blue Shift was supposed to be the exclusive extra bit in the ultimately ...
Half-life: Visitors - a Singleplayer adventure For more information please visit the official website at: www.halflife-visitors ... Half-Life: Visitors SETUP (WON). Dec 31 2011. Full Version 6 comments This is the installation setup for Half-Life: Visitors. ( ... Half-Life: Visitors SETUP (STEAM). Feb 24 2009. Full Version 13 comments This is the installation setup for Half-Life: Visitors ... Half-Life: Visitors Android port v1.1.1. Oct 31 2018. Full Version Half-Life: Visitors port. Just copy visitors folder to ...
... all of us faithful Half-Lifers felt left out of the loop. I mean, the PC was the platform that made Half-Life famous, and we ... and graphical enhancements well find in Half-Life: Blue Shift. ... When Half-Life: Blue Shift was announced as a Dreamcast-only ... So, the Half-Life High Definition Pack provides users with high-end systems with an upgrade to all of the Half-Life content ... When Half-Life: Blue Shift was announced as a Dreamcast-only title last year, all of us faithful Half-Lifers felt left out of ...
Get writing help or enjoy nearly a half million pieces of original writing. ... Half-life. Portal and Gender. ballotechnic nuclear bomb. Beggin Strips. Log in or register to write something here or to ...
Half-Life 2 (HL2) je počítačová hra vyvinutá firmou Valve Software, vydaná v roku 2004. Hlavným hrdinom je podobne ako v prvej ... Zistíte čo sa stalo po výbuchu a snažíte sa utiecť zo City 17, kvôli hroziacemu výbuchu jadra.V Half-Life 2: Episode Two je ... augusta 2017 zverejnil Marc Laidlaw na svojom blogu príbeh Half-Life 3: Episode Three, v texte však nepoužil originálne názvy ... 1. júna 2006 vyšlo pokračovanie Half-Life 2: Episode One (skôr pod menom Aftermath), ktorý je prvý z troch pripravovaných mini ...
Its hazard course for the mod Half-Life: ESCAPE. For some reasons it was released in about February 5th, 2004, separately from ... Its hazard course for the mod Half-Life: ESCAPE. For some reasons it was released in about February 5th, 2004, separately from ...
Half a Life is a starkly honest account of that fateful moment and his life thereafter . . . penetrating, thought-provoking."- ... Praise For Half a Life: A Memoir…. "Elegant, painful, stunningly honest . . . huge [and] heartbreaking."-The New York Times ... This is a book about survivors guilt that has haunted him for, literally, half of his life. Though he was cleared of wrong- ... He is a Clinical Associate Professor of Writing at New York University, and he lives with his wife and children in Brooklyn. ...
Half-Life, might be a metaphor for Marlas excursion into embracing the next life while shes in the present life shuffling off ... Although Half-Life starts off on a rock vibe, her lyrics, whether sung or spoken, are brilliantly backed by The Tomás Doncker ... To get the gist of her spoken words, she seductively ends the title track "Half-Life" with, ... While Marla is reaching her half point, some of us may have already been there while some of us are on the threshold. ...
the black mesa research facility has been studying all forms of subjects biology to weapons designs. but as of late one of there most credible scientist Markus Knell has been working on dimensional travel. he has been ridiculed and identified as a quack. but today he has mad a startling and dangerous break through. with the help of plutonium and dark matter he has torn a rip in time/space bringing forth a new dimensional hell that has been named xen dimension hundreds of strange alien creatures has pored out of the rip. the whole facility has been forced in to quarantine mode by the army which has gone in on the rule shoot everything in front of your gun that moves! and has started murdering scientist and aliens alike. it has been half a day scenes this started ...
Panasonic became the first company to announce that it extended the phosphor half life of its consumer 1080p plasma displays to ... Panasonic Extends Plasma Half Life. Joseph Palenchar ⋅ Published: August 20, 2007 Panasonic became the first company to ... Panasonic became the first company to announce that it extended the phosphor half life of its consumer 1080p plasma displays to ... Panasonic became the first company to announce that it extended the phosphor half life of its consumer 1080p plasma displays to ...
GoldenEye mod coming to Half-Life 2. Written by John Scalzo on 09/07/05. A team of modders is working on bringing the ... Half-Life 2 opens the door to a world where the players presence affects everything around him, from the physical environment ...
In Half a Life we are introduced to the compelling figure of Willie Chandran. Springing from the unhappy union of a low-caste ... In its humorous and sensitive vision of the half-lives quietly lived out at the centre of our world, V.S. Naipauls graceful ... mother and a father constantly at odds with life, Willie is naively eager to find something that will place him both in and ...
Ex-Marine Gunmans Life Was Both Unremarkable and Troubled Ian David Long enlisted in the Marines out of high school and ... Bass may be a true hero, but she also admitted she has been through times in her life when she thought it would be better not ... "She said, You saved her life. Thank you," said Bass.. Bass friend called her not long after that night to thank her for ... What started out as a typical video-conference call to a friend turned into a dramatic life-saving event. Bass was determined ...
Alan is the father to the half-a-man of the title, a kid named Jake, played by actor Angus T. Jones as a smug dunce.) The ... I fired up a recent Two and a Half Men episode, and we had ourselves a viewing party. ... Two and a Half Men (CBS, Mondays at 9 p.m. ET). That is, Id somehow developed the vague notion that the shows creator, Chuck ...
Stream Kingdom Life Half Hour free online. Listen to free internet radio, sports, music, news, talk and podcasts. Stream live ...
A Cutting Board That Cuts Prep Time in Half!. The life of a designer turned writer is quite frustrating. The number of times ...
  • Rutherford applied the principle of a radioactive element's half-life to studies of age determination of rocks by measuring the decay period of radium to lead-206. (wikipedia.org)
  • Half-life is constant over the lifetime of an exponentially decaying quantity, and it is a characteristic unit for the exponential decay equation. (wikipedia.org)
  • A half-life usually describes the decay of discrete entities, such as radioactive atoms. (wikipedia.org)
  • N(t) is the quantity that still remains and has not yet decayed after a time t, t1⁄2 is the half-life of the decaying quantity, τ is a positive number called the mean lifetime of the decaying quantity, λ is a positive number called the decay constant of the decaying quantity. (wikipedia.org)
  • Along with the original Half-Life, Gearbox exclusively addeded Decay, a two-player cooperative mode that enables players to explore the Black Mesa Facility, as well as a two-player mode for Deathmatch fans. (ign.com)
  • The radioactive half-life for a given radioisotope is the time for half the radioactive nuclei in any sample to undergo radioactive decay. (gsu.edu)
  • One half-life is the time required for one half of any given quantity of the substance to decay. (factmonster.com)
  • Decay was a bonus game mode in the Playstation 2 port of the first Half-Life, much as Blue Shift was supposed to be the exclusive extra bit in the ultimately canned Dreamcast version. (rockpapershotgun.com)
  • Tagged with free games , Half-Life Decay , mod , Half-Life . (rockpapershotgun.com)
  • The half-life of a radioactive isotope is the time it takes for half of the atoms in a pure sample of the isotope to decay into another element . (fact-index.com)
  • The concept of half life is not restricted to the decay of radioactive nuclei. (fact-index.com)
  • the slow decay of time and weather never pauses, not even in deference to the memory of a little girl who lived too short a life, no matter how fully she lived it. (meyerweb.com)
  • So, we use the time in which half of any of these unstable nuclei will decay. (bbc.co.uk)
  • is the time taken for half the unstable nuclei in a sample to decay. (bbc.co.uk)
  • A half life of a substance is the amount of time it takes to decay into half of its activity. (wikipedia.org)
  • By measurements we have learned that in the span of 4,510,000,000 years one half of the atoms in this piece of uranium will decay but we will never know which one will decay next! (madsci.org)
  • Remember, however, that the half life of uranium is always the same and that it is just that there are fewer and fewer atoms left to decay. (madsci.org)
  • we only know for sure that 1/2 of the atoms that are radioactive will decay in one half-life of the radioactive species. (madsci.org)
  • A look at how the Sporting Life recommended bets have performed in September 2018. (sportinglife.com)
  • For example, the medical sciences refer to the biological half-life of drugs and other chemicals in the human body. (wikipedia.org)
  • The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential. (wikipedia.org)
  • The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues ( protein binding ), active metabolites, and receptor interactions. (wikipedia.org)
  • The biological half-life of water in a human is about 7 to 14 days . (wikipedia.org)
  • Drinking large amounts of alcohol will reduce the biological half-life of water in the body. (wikipedia.org)
  • The biological half-life of caesium in humans is between one and four months. (wikipedia.org)
  • For some substances, it is important to think of the human or animal body as being made up of several parts, each with their own affinity for the substance, and each part with a different biological half-life ( physiologically-based pharmacokinetic modelling ). (wikipedia.org)
  • Polonium in the body has a biological half-life of about 30 to 50 days. (wikipedia.org)
  • Caesium in the body has a biological half-life of about one to four months. (wikipedia.org)
  • Lead in bone has a biological half-life of about ten years. (wikipedia.org)
  • Plutonium in the liver has a biological half-life of about 40 years. (wikipedia.org)
  • it is the analogue of biological half-life when the kinetics are governed by multiple independent mechanisms. (wikipedia.org)
  • The complexity of biological systems means that most pharmacological substances do not have a single mechanism of elimination, and hence the observed or effective half-life does not reflect that of a single process, but rather the summation of multiple independent processes. (wikipedia.org)
  • Biological half-life (represented as t 1/2) is the time required for one-half of the total amount of a particular substance in a biological system to be consumed , metabolized , or otherwise broken down by biological processes when the rate of removal is approximately exponential . (everything2.com)
  • Toxic chemical s with a long biological half-life (such as some pesticide s) will tend to accumulate in the body and are, therefore, more likely to be harmful. (everything2.com)
  • A substance with a short biological half-life may still accumulate if a portion of it it becomes tightly bound to bone or other tissue s, even if most of it is quickly cleared from the body. (everything2.com)
  • The biological or elimination half-life is the time it takes for the bioactivity of the drug to reduce by 50% of its initial value. (wisegeek.com)
  • Note that after one half-life there are not exactly one-half of the atoms remaining, only approximately, because of the random variation in the process. (wikipedia.org)
  • Nevertheless, when there are many identical atoms decaying (right boxes), the law of large numbers suggests that it is a very good approximation to say that half of the atoms remain after one half-life. (wikipedia.org)
  • This rate at which the material changes is expressed in terms of the half-life, the time required for one half the atoms initially present to disintegrate, which is constant for any particular isotope. (fact-index.com)
  • Now there are some radioactive atoms that have a much shorter half life. (madsci.org)
  • Half a Life is a 2001 novel by Nobel laureate V. S. Naipaul published by Alfred A. Knopf. (gradesaver.com)
  • Half a Life was long listed for the Man Booker prize (2001). (gradesaver.com)
  • The half-life of a particular isotope is unaffected by chemical reactions or physical changes. (bbc.co.uk)
  • half-life, measure of the average lifetime of a radioactive substance (see radioactivity ) or an unstable subatomic particle. (factmonster.com)
  • Half the world's population has no access to hygienic sanitation and cannot progress beyond "medieval" living conditions until this basic need is met, the United Nations Children's Fund (Unicef) said this week. (bmj.com)
  • 25. augusta 2017 zverejnil Marc Laidlaw na svojom blogu príbeh Half-Life 3: Episode Three , v texte však nepoužil originálne názvy hrdinov, ani názvy predchádzajúcich hier. (wikipedia.org)
  • In a March 2017 survey conducted online by Harris Poll on behalf of OneAmerica ® , only 45 percent of employed Americans claim to have voluntary group life insurance provided by their employer. (prnewswire.com)
  • A general view of oceanfront villas, one of which is believed to be one of the former homes of Kim Jong Nam, the estranged half-brother of North Korean leader Kim Jong Un, in Macau, China February 15, 2017. (reuters.com)
  • This report analyzes key aspects of initial public offerings (IPOs) for technology and life sciences companies that went public in the first half of 2016. (lexology.com)
  • Overall IPO activity for technology and life sciences companies declined in the first and second quarters of 2016, with the number of deals down sequentially compared to the third and fourth quarters of 2015. (lexology.com)
  • Life sciences companies completed 16 deals in the first half of 2016 compared to four completed by technology companies in the same period. (lexology.com)
  • The sharp decline in U.S. equity markets at the beginning of 2016 ushered in the slowest yearly start for technology and life sciences IPOs since the collapse of the markets in 2008-2009. (lexology.com)
  • With the impending election, it is unclear how the rest of 2016 will fare for high technology and life sciences companies seeking to go public. (lexology.com)
  • A group of European scientists is already prepping for a mission to search for life on Jupiter's icy moons . (foxnews.com)
  • It reflects the cumulative effect of the individual half-lives, as observed by the changes in the actual serum concentration of a drug under a given dosing regimen. (wikipedia.org)
  • Non-hydropyridinein complications of our doxazosin, lisinopril 5mg half life the serum of price reactions medical of signs is ordering truly even ten control higher than the serum within the lips. (duvalia.com)
  • Half-life (symbol t1⁄2) is the time required for a quantity to reduce to half of its initial value. (wikipedia.org)
  • The converse of half-life is doubling time. (wikipedia.org)
  • First order kinetics: In first order reactions, the concentration of the reaction will continue to decrease as time progresses until it reaches zero, and the length of half-life will be constant, independent of concentration. (wikipedia.org)
  • In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ( plasma half-life ) its steady-state. (wikipedia.org)
  • In human medicine and pharmacokinetic s, this term refers to the amount of time it takes the body to eliminate half of the amount of a chemical after it has been absorbed by the body . (everything2.com)
  • Get well, Charlie, I thought-and then realized that I had thus spent more time contemplating Sheen's elaborate indiscretions that I have watching his current sitcom, Two and a Half Men (CBS, Mondays at 9 p.m. (slate.com)
  • A Cutting Board That 'Cuts' Prep Time in Half! (yankodesign.com)
  • Half-life is the time taken when the mass or countrate emitted of a radioactive sample drops to half. (physicsforums.com)
  • Sadly, he had little time for a social life. (dilbert.com)
  • What was life like in Shakespeare's time? (reference.com)
  • There were many elements that made life difficult in Shakespeare's time, which often meant that life expectancy was very short, with most children (as many. (reference.com)
  • Half the time she had with us, elapsed in absence. (meyerweb.com)
  • Another way to define the half-life of a radioactive isotope is the time taken for count rate from a sample to decrease by a half. (bbc.co.uk)
  • Life and a Half is a place and a time of half-death-or, if one prefers, half-life. (indiana.edu)
  • A drug's half-life is the time it takes for half of a given dose to be eliminated from the body or bloodstream. (wisegeek.com)
  • The Superbowl half time show marks the second time Riccardo worked with the iconic performer, with the first being her tour three years ago. (hollywoodlife.com)
  • It's been shown time and again that there is no natural place on earth that DOESN'T have life. (newser.com)
  • That time is called the half-life of uranium. (madsci.org)
  • By that time I forgot that half dollar was even in that side, but it was and I guess it might have saved my life. (coinbooks.org)
  • It's the amount of time, if you start with a certain amount of reactant, it's the amount of time it takes to drop that down to half of the amount that you started with. (coursera.org)
  • The amount of time it takes to get your concentration down to half the amount you started with. (coursera.org)
  • It's the amount of time to take however much you start with, and drop it down to one-half its original value. (coursera.org)
  • As one time interval, whatever the half life is, whatever that time interval is the amount of time it takes to drop it down to one-half its value is its half-life. (coursera.org)
  • And what we see with first-order kinetics, is that time interval is exactly the same to drop it down to its next half as much. (coursera.org)
  • after the 1000th time it is just annoying to anyone with half a brain. (n4g.com)
  • If we do it, we find the equation of the half life of the zero order reaction: t 1 / 2 = [ A ] 0 k 2 {\displaystyle t_{1/2}={\frac {[A]_{0}}{k2}}} The t1/2 formula for a zero order reaction suggests the half-life depends on the amount of initial concentration and rate constant. (wikipedia.org)
  • In this equation, T1/2 is the half-life. (reference.com)
  • And then we will actually calculate ln 2, and that's .693, so this equation right is our half-life equation for first-order kinetics. (coursera.org)
  • It may be nearly four years old, but Half-Life is still one of the best first-person shooters ever. (ign.com)
  • Not that I'm a big PC gamer mind you, but it was hard to miss Half-Life when it stoked a revolution three years ago on the PC. (ign.com)
  • If a household watches six hours of TV per day, it would take almost 46 years for the display to dim to half it original brightness. (twice.com)
  • Uranium-238, the most prevalent isotope of uranium, has a half-life of 4.46 billion years. (reference.com)
  • This means that in 4.46 billion years, only half of the uranium would have decayed. (reference.com)
  • Uranium-235 and Uranium-234 have half-lives of 704 million and 245,000 years, respectively. (reference.com)
  • Five years ago, Kim Jong Nam pleaded with his half-brother, Kim Jong Un, to withdraw a standing order for his assassination, according to the South Korean intelligence agency. (reuters.com)
  • Half-lives of radioactive materials range from fractions of a second for the most unstable to billions of years for those which are only slightly unstable. (fact-index.com)
  • A half a mile below the surface of the West Antarctic Ice Sheet, in a lake that hasn't been touched by sunshine or wind in millions of years, life goes on. (foxnews.com)
  • Plutonium-239 has a half-life of 24,100 years but plutonium-241 has a half-life of only 14.4 years. (bbc.co.uk)
  • Carbon-14 has a half-life of about 5,700 years. (bbc.co.uk)
  • For example, if an ancient dead tree contains half the expected amount of carbon-14, it must have died about 5,700 years ago. (bbc.co.uk)
  • Timicin has spent the past forty years working on the solution to their sun, and it's obvious that his social life has been nonexistent. (tor.com)
  • Once their lives meant something, and they were forced to mean nothing, for years. (tor.com)
  • For example, biophosphonates, which are used to treat osteoporosis, are absorbed by bones and have half-lives that can extend for many years. (wisegeek.com)
  • Valve itself ported Half-Life to the Source engine years ago, though it was hardly a major overhaul. (n4g.com)
  • For example, tritium is a radioactive isotope of hydrogen which has a 1/2 life of 12.32 years. (madsci.org)
  • In 100 years the tritium will be pretty much gone because so many halflives will have passed. (madsci.org)
  • The world's urban population has also grown rapidly in recent years, with more than half the global population now living in cities. (theweek.com)
  • And so is Half-Life's original writer, Marc Laidlaw. (lesterchan.net)
  • Half-life's original writer Marc Laidlaw spoke on the cancellation a year ago, telling LambdaGeneration that they were big fans of Arkane and wanted to come up with a project they could work on together. (techspot.com)
  • The value of the half-life depends on the reaction order: Zero order kinetics: The rate of this kind of reaction does not depend on the substrate concentration. (wikipedia.org)
  • However, a Half-Life prequel might make sense, and typically the Half-Life games have released alongside new technological advancements made by Valve. (cinemablend.com)
  • A project which combines content from the cancelled Half-Life 2: Episode 3 has been released in the wake of Marc Laidlaw's "Epistle 3" posted last week. (vg247.com)
  • Valve has issued a PSA pointing out that updates to Half-life 2, Episode One, Episode Two and Lost Coast today are part of its ongoing efforts to add Steampipe support to all Source games. (vg247.com)
  • 1. júna 2006 vyšlo pokračovanie Half-Life 2: Episode One (skôr pod menom Aftermath), ktorý je prvý z troch pripravovaných mini dielov, ktoré vysvetľujú udalosti po výbuchu citadely. (wikipedia.org)
  • Zistíte čo sa stalo po výbuchu a snažíte sa utiecť zo City 17, kvôli hroziacemu výbuchu jadra.V Half-Life 2: Episode Two je cieľom vypustiť raketu, ktorá zatvorí portál vzniknutý výbuchom jadra. (wikipedia.org)
  • Záverečná časť trilógie Half-Life 2: Episode Three bola ohlásená, avšak predbežný dátum vydania zatiaľ nie je známy. (wikipedia.org)
  • Think for a sec, maybe Valve is holding back Half life 3 just like episode 2 to make a new orange box. (funnyjunk.com)
  • I fired up a recent Two and a Half Men episode, and we had ourselves a viewing party. (slate.com)
  • New images from a planned Half-Life 2 episode known as Return to Ravenholm recently surfaced online. (techspot.com)
  • Where is Half Life 2: Episode 3? (n4g.com)
  • Jon Martin from Coregamer: October 9th 2007, the day the Orange Box and Half-Life 2: Episode 2 finally came out and we got the middle part of the episodic story promised to us after Half-Life 2's original release date. (n4g.com)
  • A 'normal half-life curve' is probably a plot of the expectation value of the number of particles in a certain state or a fraction. (physicsforums.com)
  • Note that a half life curve does not indicate the mass left, just the number of particles of a certain type. (physicsforums.com)
  • If this seems strange, note that the life of half of the particles is only somewhere between 0 and the half-life, while the life of the other half can be anywhere between the half-life and infinite. (fact-index.com)
  • Elemental half-lives can be changed only through interacting with particles. (reference.com)
  • Half-Life 2 (HL2) je počítačová hra vyvinutá firmou Valve Software , vydaná v roku 2004 . (wikipedia.org)
  • It is used to help reduce the drugs of life half liquid prednisolone vitro, bulbar as year. (macrodeportes.com)
  • Drugs such as tranquilizers and pain relievers are often addictive, particularly when they have very short half-lives. (wisegeek.com)
  • HALF a million asthma sufferers are left facing the impossible choice between food or life-saving drugs, new figures have shown. (thesun.co.uk)
  • Half-Life: Opposing Force - This is the official game expansion for Half-Life. (tucows.com)
  • While we collectively wait for Half-Life 3 to happen, let's continue the story of Opposing Force. (vg247.com)
  • Prospekt is a Half-Life 2 game which continues the story of the Gearbox Software-developed Opposing Force, and it is now available for pre-order on Steam. (vg247.com)
  • But Half-Life plays as much like a platform game in many respects as it does a traditional first-person shooter. (ign.com)
  • Following Portal, Valve's classic shooter Half-Life 2 is now available on Nvidia's Shield. (vg247.com)
  • Uranium-235 and uranium-234 have shorter half-lives, which make them more radioactive. (reference.com)
  • the shorter the half life, the less stable the atom . (fact-index.com)
  • The half-life is shorter than the average lifetime . (fact-index.com)
  • In this powerful, unforgettable memoir, acclaimed novelist Darin Strauss examines the far-reaching consequences of the tragic moment that has shadowed his whole life. (indiebound.org)
  • This patch fixes most issues related to engine branch incompatibility and is designed to run using the latest 'Beta' of Half-Life Steam version. (moddb.com)
  • For example, oxytocin has a half-life of typically about three minutes in the blood when given intravenously . (wikipedia.org)
  • And at around five hours, the Surface Pro still gets less battery life than do most laptops, which typically get around 6 hours of battery life. (latimes.com)
  • The effects of a drug typically begin to taper off as the first half-life point is reached. (wisegeek.com)
  • Sporting a new name and an exciting new course, the Mancos Half Marathon - formerly the Cowboy Half Marathon - promises to be a fun and varied event for all. (durangoherald.com)
  • We have added a 5K distance and a fun run in addition to the half marathon distance which offers many more opportunities for members of the community to participate. (durangoherald.com)
  • According to Runner's World magazine, more than 2 million runners completed a half marathon distance race in 2014, making it the fastest growing distance in the sport, second only to the 5K distance. (durangoherald.com)
  • The half marathon is a great running distance, just long enough that you can't race it off the couch, but if you train seriously it will reward you and won't beat you up like a full marathon can. (durangoherald.com)
  • The Four Corners community is keeping pace with this growing trend by continually offering new and different half marathon races annually. (durangoherald.com)
  • The Durango Half Marathon, Steamworks Half Marathon, the Mancos Half Marathon, the Thirsty Thirteen and the Durango Double. (durangoherald.com)
  • For more information and to register for the Mancos Half Marathon, visit their web page at mancoshalfmarathon.com. (durangoherald.com)
  • What is the half-life of uranium? (reference.com)
  • the other half of the sample remains uranium-238. (reference.com)
  • Re: How come element like uranium have such a long half-life? (madsci.org)
  • Darin Strauss has spent a good part of his adult life reliving, regretting and reflecting on a single, split-second incident. (indiebound.org)
  • The half-life is ln 2 ≈ 0.693 times the average life. (fact-index.com)
  • The original term, half-life period, dating to Ernest Rutherford's discovery of the principle in 1907, was shortened to half-life in the early 1950s. (wikipedia.org)
  • This modification will stretch your Half-Life experience with unused, cut and retail version content from original game. (steampowered.com)
  • Fixing annoying bugs of original Half-Life ‎‎‎‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎‏‏‎ ‎and much more. (steampowered.com)
  • For those of you who haven't played Half-Life on the PC, Gearbox's PS2 version brings back the original game in true form to Sony's system, at least in terms of gameplay. (ign.com)
  • After two half-lives, there will be one fourth the original sample, after three half-lives one eight the original sample, and so forth. (gsu.edu)
  • If you remember, in the original Half-Life, when Gordon starts his day at work, he rides a tram into the Black Mesa. (ign.com)
  • The Blue Shift narrative occurs simultaneously to the plot of the original Half-Life, so you're job is to protect the civilians of Black Mesa against the aliens and assassins that assault the facility. (ign.com)
  • Since the release of Half-Life, new advances in 3d acceleration and CPU power have enabled most users to seriously exceed the minimum system requirements of the original game. (ign.com)
  • By taking the suspense, challenge and visceral charge of the original, and adding startling new realism and responsiveness, Half-Life 2 opens the door to a world where the player's presence affects everything around him, from the physical environment to the behaviors -- even the emotions -- of both friends and enemies. (gamingtarget.com)
  • I ate at both halves of Half & Half, and I must say that although the concept of MEDIAnoche was intriguing, its food left me disappointed, while Half & Half's breakfast (the restaurant's original purpose) left me wishing it was open 24 hours a day. (studlife.com)
  • As part of the experiment that nearly destroys the facility, Gordon Freeman must transform from a scientist several other roles: as a soldier, he must defend himself from a strange set of alien forms, as an adventurer he must escape from the crumbling lab, and as an investigator, he must seek out the reason for the "freak accident" and why his own life has been put in danger. (ign.com)
  • By continuing to use our formula without changing the models, prednisolone liquid half life you are agreeing to our information of effective people. (macrodeportes.com)
  • What Is the Half-Life Formula in Math? (reference.com)
  • The formula for a half-life is T1/2 = ln(2) / λ. (reference.com)
  • The formula for half-life in chemistry depends on the order of the reaction. (reference.com)
  • The armament is the only part of the Half-Life formula that's starting to go stale. (gamesradar.com)
  • So let's derive the half-life formula. (coursera.org)
  • Previously known as Restore-Life, Half-Life: Restored brings unused, cut & retail features of Half-Life into a one game. (steampowered.com)
  • Needless to say, Half-Life was, and still is, a brilliant game from head to toe. (ign.com)
  • Sierra's Half-Life for PS2 is indeed a game worth owning, not just because of its timelessly good gameplay, but because developer Gearbox (which created the add-on pack Half-Life: Opposing Forces) went out of its way to stuff more modes of play and extras than any of the PC games have ever seen. (ign.com)
  • Throughout the game, both friends and foes behave in sophisticated and unpredictable ways, a result of Half-Life's powerful and innovative artificial intelligence. (tucows.com)
  • Half-Life 2: Update will be available tomorrow, and thanks to the modding community, those who own the vanilla version of the game can apply a visual update to the 2004 title. (vg247.com)
  • The first game I've played was on Xbox 360, and now I don't know what to do to install a mod for half life1! (moddb.com)
  • We recently had a chance to talk to Gearbox's Chief Designer, Randy Pitchford, about the upcoming game, and here's what he had to say about the mission structure, new weapons, and graphical enhancements we'll find in Half-Life: Blue Shift. (ign.com)
  • There are now rumors floating about that a new Half-Life game could be bundled in with new VR hardware. (cinemablend.com)
  • If it is a new consumer headset that comes with a new Half-Life game made specifically for VR, would that be enough to convince you to take the plunge into virtual reality? (cinemablend.com)
  • Note: A separate article treats the Half-Life computer game . (fact-index.com)
  • The most intense action in a Half-Life game yet. (gamesradar.com)
  • The game both looks and sounds better than Half-Life: Source, and really, it's superior in most every way. (n4g.com)
  • To put it in context, the iPad, for example, gets 10 hours of battery life as well. (latimes.com)
  • Though shot, knifed, butchered, and bled, Martial's spirit lives on to guide his followers in their fight against the dictators. (indiana.edu)
  • Never miss a story from half truths , when you sign up for Medium. (medium.com)
  • This episodic installment continues the Half-Life 2 legend with a whole chapter of brand new content. (gamesradar.com)
  • Half is what has now launched me into this really exciting episodic adventure. (deadline.com)
  • So, the Half-Life High Definition Pack provides users with high-end systems with an upgrade to all of the Half-Life content that takes advantage of their hardware. (ign.com)
  • But the power of the Intel Core i5 processor comes at the expense of battery life, and Microsoft has already confirmed on Twitter that the Surface Pro has just half the battery life of the Surface RT, as pointed out by ZDNet . (latimes.com)
  • That has led scientists to wonder whether primitive (but hearty) life thrives there as well, Forbes reports. (foxnews.com)
  • Half Broke Horses is Laura Ingalls Wilder for adults, as riveting and dramatic as Isak Dinesen's Out of Africa or Beryl Markham's West with the Night . (indiebound.org)
  • Listed as one of the 100 best books on Africa, Life and a Half was Sony Labou Tansi's response to the death of close friends during a bloody military and political crackdown in Congo. (indiana.edu)
  • When Half-Life: Blue Shift was announced as a Dreamcast-only title last year, all of us faithful Half-Lifers felt left out of the loop. (ign.com)
  • Alan is the father to the half-a-man of the title, a kid named Jake, played by actor Angus T. Jones as a smug dunce. (slate.com)
  • The medications a person is taking can interact with one another to modify the half-life of any of them as well. (wisegeek.com)
  • UploadVR is reporting that a source close to the project informed them that this new hardware is expected to release at some point in 2019, and that it will come bundled with Half-Life . (cinemablend.com)
  • UK comedy heroes Paul and Barry Chuckle are in Half-Life mod Black Mesa. (vg247.com)
  • But when death and love, perhaps, arrive unexpectedly, Adam must learn that trouble sometimes has to rumble through a tidy world to make room for the kind of magical connections that make life worth living. (wikipedia.org)
  • A group of folks have restored VR code for Half-Life 2 (HLVR) in order to make it playable on Oculus and HTC Vive. (vg247.com)
  • Learn how to make the latter half of life the most meaningful. (canyonranch.com)
  • MACAU (Reuters) - Before he was killed in Malaysia, Kim Jong Nam, the estranged half-brother of North Korea's leader, lived quietly in the Asian gambling hub of Macau, avoiding controversy and seemingly relaxed about personal safety, according to sources close to him. (reuters.com)
  • Did you know there's an official slice of the Half-Life saga that never found its way to PC? (rockpapershotgun.com)
  • Beside the story, which integrates completely into the Half-Life saga, you can find background information, pictures and videos. (moddb.com)
  • Half a Life study guide contains a biography of V.S. Naipaul, literature essays, quiz questions, major themes, characters, and a full summary and analysis. (gradesaver.com)
  • Half life is also relative to the subjective metabolic rate of the individual in question. (wikipedia.org)
  • If you're successful, Blue Shift has what many have called the most satisfying Half-Life ending yet. (ign.com)
  • Her father, who also suffers from cancer and is treated at the same hospital, describes the new reality which shapes the life of his family these days. (jpost.com)
  • The E-Sylum: Volume 10, Number 30, July 29, 2007, Article 29 HALF DOLLAR SAVED MAN'S LIFE An article about a donation to a local museum describes how a coin saved the life of a WW II soldier: "A single coin may have saved a local soldier's life. (coinbooks.org)
  • "The Second Half of Life is a wise, unique, and beautifully written guidebook for those who want to live every day of their lives. (feedbooks.com)
  • With The Second Half of Life, she takes you step-by-step through each gate to deepen your most valuable relationships, reclaim your untended creative talents, and shift your focus from ambition to meaning to grow into the exceptional elder you've always imagined you would one day become. (feedbooks.com)
  • Second Half of Life: What Is Required to Flourish? (canyonranch.com)
  • OneAmerica has companies that offer employer-paid and voluntary term life insurance (where the employee pays for the life insurance benefit, but receives a group rate). (prnewswire.com)
  • Notice how the count rate falls to half its previous value every four days. (bbc.co.uk)
  • Analogues and lisinopril 5mg half life weighed in tab rate but these arts, but start doing possible drug pager. (duvalia.com)
  • Many things can influence a drug's clearance rate and half-life. (wisegeek.com)
  • Fee for all weekly programs at the Life Enhancement Center is $500 above your package rate. (canyonranch.com)
  • And you're going to learn to employ the concept of half-life and see the relationship between a rate constant and the value for half-life, and be able to utilize those into calculations. (coursera.org)
  • While life sciences IPOs fell to their lowest half-year rate since 2011, their totals far outpaced technology IPOs. (lexology.com)
  • This is a book about survivor's guilt that has haunted him for, literally, half of his life. (indiebound.org)
  • Ryan Murphy and the Half foundation have literally changed my life," Alexis Ostrander said. (deadline.com)
  • Such a treatment is offered in a hospital in North Carolina but had never been given to any non-US citizen and the cost of the procedure, as well as for the entire family staying in N. Carolina during the medical procedure - is nearly half a million nis [127,000 USD]. (jpost.com)
  • Carolina Science Online®, our new eLearning platform, brings your classroom to life with resources for all ages. (carolina.com)
  • Carolina covers the world of life science with everything from slides and kits to Agricultural and Vet Science. (carolina.com)
  • Based on our renal series, our catheter is real that compared to prednisolone liquid half life younger side outcomes, older trousers have more previous interviews associated with upcoming steroid and are more actual to granulomatosis. (macrodeportes.com)
  • The accompanying table shows the reduction of a quantity as a function of the number of half-lives elapsed. (wikipedia.org)
  • The radioactive half-life gives a pattern of reduction to half in any successive half-life period. (gsu.edu)
  • Dose: the doctor pressure of familiar medicinei in goofy patients receiving stroke has been reported to induce reduction and life half 5mg lisinopril medical pressure. (duvalia.com)
  • More information prednisolone is to prednisolone liquid half life be used not by the free glucose for whom it is prescribed. (macrodeportes.com)
  • This free, community made Mod requires that you own Half-Life . (steampowered.com)
  • The charity says it's unfair that people with asthma in England have to pay for life-saving medication, especially as people with other long-term conditions such as diabetes and epilepsy, and those in the rest of the UK, get free prescriptions. (thesun.co.uk)
  • Newser) - A man wrongly convicted of rape is finally free after spending nearly half his life in prison. (newser.com)