A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.
A type of H. influenzae isolated most frequently from biotype I. Prior to vaccine availability, it was a leading cause of childhood meningitis.
Infections with bacteria of the genus HAEMOPHILUS.
Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.
Infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. HAEMOPHILUS INFLUENZAE TYPE B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults.
Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.
An envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.
Polysaccharides found in bacteria and in capsules thereof.
A genus of PASTEURELLACEAE that consists of several species occurring in animals and humans. Its organisms are described as gram-negative, facultatively anaerobic, coccobacillus or rod-shaped, and nonmotile.
Two or more vaccines in a single dosage form.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.
Inflammation of the epiglottis.
The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.
Schedule giving optimum times usually for primary and/or secondary immunization.
A suspension of formalin-inactivated poliovirus grown in monkey kidney cell tissue culture and used to prevent POLIOMYELITIS.
Proteins isolated from the outer membrane of Gram-negative bacteria.
Immunoelectrophoresis in which immunoprecipitation occurs when antigen at the cathode is caused to migrate in an electric field through a suitable medium of diffusion against a stream of antibody migrating from the anode as a result of endosmotic flow.
Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.
Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.
Substances elaborated by bacteria that have antigenic activity.
A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.
Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.
The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.
A species of HAEMOPHILUS that appears to be the pathogen or causative agent of the sexually transmitted disease, CHANCROID.
The middle portion of the pharynx that lies posterior to the mouth, inferior to the SOFT PALATE, and superior to the base of the tongue and EPIGLOTTIS. It has a digestive function as food passes from the mouth into the oropharynx before entering ESOPHAGUS.
A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.
Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)
The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
A class of carrier proteins that bind to TRANSFERRIN. Many strains of pathogenic bacteria utilize transferrin-binding proteins to acquire their supply of iron from serum.
A thin leaf-shaped cartilage that is covered with LARYNGEAL MUCOSA and situated posterior to the root of the tongue and HYOID BONE. During swallowing, the epiglottis folds back over the larynx inlet thus prevents foods from entering the airway.
A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).
Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).
An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)
A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.
Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.
Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.
Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
Strains of Neisseria meningitidis responsible for most sporadic cases in teenagers and almost all outbreaks of disease in this age group. These strains are less common in infants.
The functional hereditary units of BACTERIA.
Proteins found in any species of bacterium.
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.
A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
A genus of the family Chinchillidae which consists of three species: C. brevicaudata, C. lanigera, and C. villidera. They are used extensively in biomedical research.
Substances that reduce the growth or reproduction of BACTERIA.
An infant during the first month after birth.
Gram-negative aerobic cocci of low virulence that colonize the nasopharynx and occasionally cause MENINGITIS; BACTEREMIA; EMPYEMA; PERICARDITIS; and PNEUMONIA.
Vaccines or candidate vaccines used to prevent infections with STREPTOCOCCUS PNEUMONIAE.
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Nonsusceptibility of a microbe to the action of ampicillin, a penicillin derivative that interferes with cell wall synthesis.
Nonsusceptibility of an organism to the action of penicillins.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Acute suppurative inflammation of the inner eye with necrosis of the sclera (and sometimes the cornea) and extension of the inflammation into the orbit. Pain may be severe and the globe may rupture. In endophthalmitis the globe does not rupture.
Facilities which provide care for pre-school and school-age children.
The heritable modification of the properties of a competent bacterium by naked DNA from another source. The uptake of naked DNA is a naturally occuring phenomenon in some bacteria. It is often used as a GENE TRANSFER TECHNIQUE.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.
Semisynthetic broad-spectrum cephalosporin.
The cause of TETANUS in humans and domestic animals. It is a common inhabitant of human and horse intestines as well as soil. Two components make up its potent exotoxin activity, a neurotoxin and a hemolytic toxin.
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
A species of gram-negative bacteria in the genus HAEMOPHILUS found, in the normal upper respiratory tract of SWINE.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The classes of immunoglobulins found in any species of animal. In man there are nine classes that migrate in five different groups in electrophoresis; they each consist of two light and two heavy protein chains, and each group has distinguishing structural and functional properties.
Allelic variants of the immunoglobulin light chains (IMMUNOGLOBULIN LIGHT CHAINS) or heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) encoded by ALLELES of IMMUNOGLOBULIN GENES.
A republic in western Africa, constituting an enclave within SENEGAL extending on both sides of the Gambia River. Its capital is Banjul, formerly Bathurst.
A species of gram-negative bacteria in the genus HAEMOPHILUS, ubiquitous in the human ORAL CAVITY and PHARYNX. It has low pathogenicity but is occasionally implicated in ENDOCARDITIS in humans.
Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
Vaccines used to prevent POLIOMYELITIS. They include inactivated (POLIOVIRUS VACCINE, INACTIVATED) and oral vaccines (POLIOVIRUS VACCINE, ORAL).
Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).
Inflammation of the lung parenchyma that is caused by bacterial infections.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).
Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.
A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.
Sites on an antigen that interact with specific antibodies.
Proteins that specifically bind to IRON.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The sum of the weight of all the atoms in a molecule.
Proteins that bind to particles and cells to increase susceptibility to PHAGOCYTOSIS, especially ANTIBODIES bound to EPITOPES that attach to FC RECEPTORS. COMPLEMENT C3B may also participate.
Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Resistance to a disease-causing agent induced by the introduction of maternal immunity into the fetus by transplacental transfer or into the neonate through colostrum and milk.
A property of the surface of an object that makes it stick to another surface.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).
Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.
A combined vaccine used to prevent MEASLES; MUMPS; and RUBELLA.
Surgical procedure involving either partial or entire removal of the spleen.
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
Proteins that are structural components of bacterial fimbriae (FIMBRIAE, BACTERIAL) or sex pili (PILI, SEX).
Infections by bacteria, general or unspecified.
Techniques for removal by adsorption and subsequent elution of a specific antibody or antigen using an immunosorbent containing the homologous antigen or antibody.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Antibodies produced by a single clone of cells.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
Acute, localized autoinoculable infectious disease usually acquired through sexual contact. Caused by HAEMOPHILUS DUCREYI, it occurs endemically almost worldwide, especially in tropical and subtropical countries and more commonly in seaports and urban areas than in rural areas.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.
Method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.
Elements of limited time intervals, contributing to particular results or situations.
Transport proteins that carry specific substances in the blood or across cell membranes.
Infection of the lung often accompanied by inflammation.
A live attenuated virus vaccine of duck embryo or human diploid cell tissue culture origin, used for routine immunization of children and for immunization of nonpregnant adolescent and adult females of childbearing age who are unimmunized and do not have serum antibodies to rubella. Children are usually immunized with measles-mumps-rubella combination vaccine. (Dorland, 28th ed)
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.
A species of gram-negative bacteria (currently incertae sedis) causing multisystem disease in CATTLE.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Countries in the process of change with economic growth, that is, an increase in production, per capita consumption, and income. The process of economic growth involves better utilization of natural and human resources, which results in a change in the social, political, and economic structures.
Infections with bacteria of the family MORAXELLACEAE.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
Refers to animals in the period of time just after birth.
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Inflammation of the middle ear with a clear pale yellow-colored transudate.
Techniques used in studying bacteria.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
One of the types of light chains of the immunoglobulins with a molecular weight of approximately 22 kDa.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
The quality of not being miscible with another given substance without a chemical change. One drug is not of suitable composition to be combined or mixed with another agent or substance. The incompatibility usually results in an undesirable reaction, including chemical alteration or destruction. (Dorland, 27th ed; Stedman, 25th ed)
Administration of a vaccine to large populations in order to elicit IMMUNITY.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
Strains of Neisseria meningitidis responsible for most outbreaks of meningococcal disease in Western Europe and the United States in the first half of the 20th century. They continue to be a major cause of disease in Asia and Africa, and especially localized epidemics in Sub-Sahara Africa.
Nonsusceptibility of bacteria to the action of CHLORAMPHENICOL, a potent inhibitor of protein synthesis in the 50S ribosomal subunit where amino acids are added to nascent bacterial polypeptides.
Facilities which provide care for infants.
Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Compounds based on ERYTHROMYCIN with the 3-cladinose replaced by a ketone. They bind the 23S part of 70S bacterial RIBOSOMES.
Child hospitalized for short term care.
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

A case-control study of risk factors for Haemophilus influenzae type B disease in Navajo children. (1/240)

To understand the potential risk factors and protective factors for invasive Haemophilus influenzae type b (Hib) disease, we conducted a case-control study among Navajo children less than two years of age resident on the Navajo Nation. We analyzed household interview data for 60 cases that occurred between August 1988 and February 1991, and for 116 controls matched by age, gender, and geographic location. The Hib vaccine recipients were excluded from the analyses. Conditional logistic regression models were fit to examine many variables relating to social and environmental conditions. Risk factors determined to be important were never breast fed (odds ratio [OR] = 3.55, 95% confidence interval [CI] = 1.52, 8.26), shared care with more than one child less than two years of age (OR = 2.32, 95% CI = 0.91, 5.96); wood heating (OR = 2.14, 95% CI = 0.91, 5.05); rodents in the home (OR = 8.18, 95% CI = 0.83, 80.7); and any livestock near the home (OR = 2.18, 95% CI = 0.94, 5.04).  (+info)

Efficacy of Haemophilus influenzae type b conjugate vaccines and persistence of disease in disadvantaged populations. The Haemophilus Influenzae Study Group. (2/240)

OBJECTIVES: The purpose of this study was to evaluate the effectiveness of Haemophilus influenzae type b (Hib) conjugate vaccines among children aged 2 to 18 months and to determine risk factors for invasive Hib disease during a period of declining incidence (1991-1994). METHODS: A prospective population-based case-control study was conducted in a multistate US population of 15.5 million. A laboratory-based active surveillance system was used for case detection. RESULTS: In a multivariate analysis, having a single-parent mother (odds ratio [OR] = 4.3, 95% confidence interval [CI] = 1.2, 14.8) and household crowding (OR = 3.5, 95% CI = 1.03, 11.7) were risk factors for Hib disease independent of vaccination status. After adjustment for these risk factors, the protective efficacy of 2 or more Hib vaccine doses was 86% (95% CI = 16%, 98%). Among undervaccinated subjects, living with a smoker (P = .02) and several indicators of lower socioeconomic status were risk factors for Hib disease. CONCLUSIONS: Hib disease still occurs at low levels in the United States, predominantly in socioeconomically disadvantaged populations. Low immunization coverage may facilitate continuing transmission of Hib. Special efforts to achieve complete and timely immunization in disadvantaged populations are needed.  (+info)

Structural requirements of the major protective antibody to Haemophilus influenzae type b. (3/240)

Protective antibodies to the important childhood pathogen Haemophilus influenzae type b (Hib) are directed against the capsular polysaccharide (HibCP). Most of the antibody is encoded by a well-defined set of ("canonical") immunoglobulin genes, including the Vkappa A2 gene, and expresses an idiotypic marker (HibId-1). In comparison to noncanonical antibodies, the canonical antibody is generally of higher avidity, shows higher levels of in vitro bactericidal activity, and is more protective in infant rats. Using site-directed mutagenesis, we here characterize canonical HibCP antibodies expressed as antigen-binding fragments (Fabs) in Escherichia coli, define amino acids involved in antigen binding and idiotype expression, and propose a three-dimensional structure for the variable domains. We found that canonical Fabs, unlike a noncanonical Fab, bound effectively to HibCP in the absence of somatic mutations. Nevertheless, pronounced mutation-based affinity maturation was demonstrated in vivo. An almost perfect correlation was found between unmutated gene segments that mediated binding in vitro and those encoding canonical HibCP antibodies in vivo. Thus, the Vkappa A2a gene could be replaced by the A2c gene but not by the highly homologous sister gene, A18b, corresponding to the demonstrated usage of A2c but not of A18b in vivo. Similarly, only Jkappa1 and Jkappa3, which predominate in the response in vivo, were able to facilitate binding in vitro. These findings suggest that the restricted immunoglobulin gene usage in HibCP antibodies reflects strict structural demands ensuring relatively high affinity prior to somatic mutations-requirements met by only a limited spectrum of immunoglobulin gene combinations.  (+info)

Neutralization of macrophage inflammatory protein 2 (MIP-2) and MIP-1alpha attenuates neutrophil recruitment in the central nervous system during experimental bacterial meningitis. (4/240)

Chemokines are low-molecular-weight chemotactic cytokines that have been shown to play a central role in the perivascular transmigration and accumulation of specific subsets of leukocytes at sites of tissue damage. Using in situ hybridization (ISH), we investigated the mRNA induction of macrophage inflammatory protein 2 (MIP-2), MIP-1alpha, monocyte chemoattractant protein 1 (MCP-1), and RANTES. Challenge of infant rats' brains with Haemophilus influenzae type b intraperitoneally resulted in the time-dependent expression of MIP-2, MIP-1alpha, MCP-1, and RANTES, which was maximal 24 to 48 h postinoculation. Immunohistochemistry showed significant increases in neutrophils and macrophages infiltrating the meninges, the ventricular system, and the periventricular area. The kinetics of MIP-2, MIP-1alpha, MCP-1, and RANTES mRNA expression paralleled those of the recruitment of inflammatory cells and disease severity. Administration of anti-MIP-2 or anti-MIP-1alpha antibodies (Abs) resulted in significant reduction of neutrophils. Administration of anti-MCP-1 Abs significantly decreased macrophage infiltration. Combined studies of ISH and immunohistochemistry showed that MIP-2- and MIP-1alpha-positive cells were neutrophils and macrophages. MCP-1-positive cells were neutrophils, macrophages, and astrocytes. Expression of RANTES was localized predominantly to resident astrocytes and microglia. The present study indicates that blocking of MIP-2 or MIP-1alpha bioactivity in vivo results in decreased neutrophil influx. These data are also the first demonstration that the C-C chemokine MIP-1alpha is involved in neutrophil recruitment in vivo.  (+info)

Antibody response to accelerated Hib immunisation in preterm infants receiving dexamethasone for chronic lung disease. (5/240)

AIM: To study the effect of dexamethasone on the routine immunisation of preterm infants with chronic lung disease. METHODS: Serum samples were obtained before and after immunisation from an unselected cohort of 59 preterm infants. Haemophilus influenzae antibodies were measured using an ELISA method and differences in the geometric mean values between the two groups of babies analysed. RESULTS: Sixteen infants received no dexamethasone. Before and after immunisation antibody titres for those receiving no dexamethasone were 0.16 and 4.63 mcg IgG/ml. Corresponding values for those receiving dexamethasone were 0.10 and 0.51 mcg IgG/ml, respectively. CONCLUSION: Dexamethasone used in the treatment of chronic lung disease seems to significantly affect the antibody response of preterm infants to immunisation against Haemophilus influenzae.  (+info)

Effect of multiple mutations in the hemoglobin- and hemoglobin-haptoglobin-binding proteins, HgpA, HgpB, and HgpC, of Haemophilus influenzae type b. (6/240)

Haemophilus influenzae requires heme for growth and can utilize hemoglobin and hemoglobin-haptoglobin as heme sources. We previously identified two hemoglobin- and hemoglobin-haptoglobin-binding proteins, HgpA and HgpB, in H. influenzae HI689. Insertional mutation of hgpA and hgpB, either singly or together, did not abrogate the ability to utilize or bind either hemoglobin or the hemoglobin-haptoglobin complex. A hemoglobin affinity purification method was used to isolate a protein of approximately 120 kDa from the hgpA hgpB double mutant. We have cloned and sequenced the gene encoding this third hemoglobin/hemoglobin-haptoglobin binding protein and designate it hgpC. Insertional mutation of hgpC did not affect the ability of the strain to utilize either hemoglobin or hemoglobin-haptoglobin. An hgpA hgpB hgpC triple mutant constructed by insertional mutagenesis showed a reduced ability to use the hemoglobin-haptoglobin complex but was unaltered in the ability to use hemoglobin. A second class of mutants was constructed in which the entire structural gene of each of the three proteins was deleted. The hgpA hgpB hgpC complete-deletion triple mutant was unable to utilize the hemoglobin-haptoglobin complex and showed a reduced ability to use hemoglobin. We have identified three hemoglobin/hemoglobin-haptoglobin-binding proteins in Haemophilus influenzae. Any one of the three proteins is sufficient to support growth with hemoglobin-haptoglobin as the heme source, and expression of at least one of the three is essential for hemoglobin-haptoglobin utilization. Although the three proteins play a role in hemoglobin utilization, an additional hemoglobin acquisition mechanism(s) exists.  (+info)

The induction of immunologic memory after vaccination with Haemophilus influenzae type b conjugate and acellular pertussis-containing diphtheria, tetanus, and pertussis vaccine combination. (7/240)

The significance of reduced antibody responses to the Haemophilus influenzae type b (Hib) component of acellular pertussis-containing combination vaccines (DTaP-Hib) is unclear. A DTaP-Hib vaccine evaluated in infants vaccinated at ages 2, 3, and 4 months showed reduced anti-Hib polysaccharide IgG (geometric mean concentration [GMC], 1.23 microgram/mL; 57%, >1.0 microgram/mL). Polyribitolribosyl phosphate (PRP) and Hib conjugate (PRP-T) vaccine given as a booster during the second year of life was evaluated for the presence of immunological memory. After boosting, most children achieved anti-PRP IgG >1.0 microgram/mL, although the GMC was higher with PRP-T (88.5 microgram/mL) than with PRP vaccine (7.86 microgram/mL, P<.001). The GMC of the PRP group was higher than anticipated for naive PRP recipients of the same age. PRP-specific IgG avidity was significantly higher after boosting than after priming, providing further evidence for the generation of memory. Despite reduced immunogenicity, DTaP-Hib combination vaccines appear to prime for immunologic memory.  (+info)

The pathogenic role of fimbriae of Haemophilus influenzae type b in murine bacteraemia and meningitis. (8/240)

Complement activation and development of murine bacteraemia and meningitis following intranasal instillation of cell-bound fimbriated or non-fimbriated organisms were compared to clarify the role of fimbriae in the pathogenesis of illnesses caused by Haemophilus influenza type b (Hib). In-vitro resistance of non-fimbriate bacteria to the bactericidal effects of normal human serum was at least 400 times greater than that of fimbriate bacteria. The amount of C3 bound to fimbriate Hib was more than that to non-fimbriate Hib. When mice were infected with fimbriate bacteria, 11.5% died. When mice were infected with non-fimbriate bacteria, the mean number of viable organisms gradually increased or was constant up to day 7; 38.5% of these mice died. These in-vivo results were coincident with the in-vitro data. However, the content of polyribosyl ribitol phosphate (PRP) in fimbriate organisms was the same as in non-fimbriate organisms. These results indicate that fimbriate Hib may be less likely to produce bacteraemia and meningitis, correlating with the greater susceptibility to complement-mediated bacteriolysis and the lower mortality seen with this type of organism, although fimbriae increase adherence to epithelial cells (mucosal surface).  (+info)

Epidemiology of Haemophilus Infections:

* Incidence: Hib disease was once a major cause of childhood meningitis and sepsis, but the introduction of Hib vaccines in the 1980s has significantly reduced the incidence of invasive Hib disease. Non-invasive Hib disease, such as otitis media, is still common.
* Prevalence: Hib is the leading cause of bacterial meningitis in children under the age of 5 worldwide. In developed countries, the prevalence of invasive Hib disease has decreased significantly since the introduction of vaccines, but it remains a significant public health problem in developing countries.
* Risk factors: young age, poverty, lack of access to healthcare, and poor sanitation and hygiene are risk factors for Hib disease. Children under the age of 5, especially those under the age of 2, are at highest risk for invasive Hib disease.

Pathophysiology of Haemophilus Infections:

* Mechanisms of infection: H. influenzae can cause both respiratory and non-respiratory infections by colonizing the nasopharynx and other mucosal surfaces. The bacteria can then disseminate to other parts of the body, causing invasive disease.
* Immune response: the immune response to Hib infection involves both humoral and cell-mediated immunity. Antibodies play a crucial role in protecting against reinfection, while T cells and macrophages help to clear the bacteria from the body.

Clinical Presentation of Haemophilus Infections:

* Respiratory infections: H. influenzae can cause various respiratory tract infections, including bronchitis, pneumonia, and sinusitis. Symptoms may include fever, cough, sore throat, and difficulty breathing.
* Non-respiratory infections: Hib can cause a range of non-respiratory infections, including meningitis, epiglottitis, and septic arthritis. These infections can have more severe symptoms and may require prompt medical attention.

Diagnosis of Haemophilus Infections:

* Diagnostic tests: diagnosis of Hib disease is based on a combination of clinical findings, laboratory tests, and radiologic studies. Blood cultures, lumbar puncture, and chest x-rays may be used to confirm the presence of the bacteria and assess the extent of infection.
* Laboratory testing: identification of Hib is based on its distinctive gram stain appearance and biochemical characteristics. Polymerase chain reaction (PCR) and DNA sequencing are also used to confirm the diagnosis.

Treatment and Prevention of Haemophilus Infections:

* Antibiotics: Hib infections are treated with antibiotics, such as amoxicillin or ceftriaxone. The choice of antibiotic depends on the severity and location of the infection.
* Vaccination: the Hib vaccine is recommended for children under 5 years old to prevent Hib disease. The vaccine is given in a series of 3-4 doses, with the first dose given at 2 months of age.
* Good hygiene practices: good hygiene practices, such as frequent handwashing and proper cleaning and disinfection, can help prevent the spread of Hib bacteria.

Complications of Haemophilus Infections:

* Meningitis: Hib meningitis can have serious complications, including hearing loss, learning disabilities, and seizures.
* Permanent brain damage: Hib infections can cause permanent brain damage, including cognitive and behavioral impairments.
* Respiratory failure: severe Hib pneumonia can lead to respiratory failure, which may require mechanical ventilation.
* Death: Hib infections can be life-threatening, especially in young children and those with underlying medical conditions.

In conclusion, Haemophilus infections are a serious public health concern, particularly for young children and those with underlying medical conditions. Prevention through vaccination and good hygiene practices is essential to reduce the risk of infection. Early diagnosis and treatment are critical to prevent complications and improve outcomes.

Symptoms of epiglottitis may include:

* Sudden onset of sore throat
* Fever
* Difficulty swallowing
* Hoarseness or a "barky" cough
* Pain with swallowing
* Enlarged tonsils
* Swollen lymph nodes in the neck

In severe cases, epiglottitis can lead to:

* Airway obstruction
* Respiratory failure

Treatment of epiglottitis typically involves antibiotics for bacterial infections and supportive care such as fluids, oxygen therapy, and pain management. In severe cases, surgical intervention may be necessary to remove the affected tissue.

Prevention of epiglottitis includes:

* Good hand washing practices
* Avoiding close contact with people who are sick
* Keeping up to date on vaccinations
* Practicing safe oral hygiene

It is important to seek medical attention immediately if symptoms of epiglottitis develop, as prompt treatment can help prevent serious complications.

Symptoms of meningitis may include fever, headache, stiff neck, confusion, nausea and vomiting, and sensitivity to light. In severe cases, it can lead to seizures, brain damage, and even death.

There are several types of meningitis, including:

1. Viral meningitis: This is the most common form of the infection and is usually caused by enteroviruses or herpesviruses. It is typically less severe than bacterial meningitis and resolves on its own with supportive care.
2. Bacterial meningitis: This is a more serious form of the infection and can be caused by a variety of bacteria, such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. It requires prompt antibiotic treatment to prevent long-term complications and death.
3. Fungal meningitis: This type of meningitis is more common in people with weakened immune systems and is caused by fungi that are commonly found in the environment. It can be treated with antifungal medications.
4. Parasitic meningitis: This type of meningitis is rare and is caused by parasites that are typically found in tropical regions. It can be treated with antiparasitic medications.

Diagnosis of meningitis is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include blood cultures, polymerase chain reaction (PCR) testing, and cerebrospinal fluid (CSF) analysis. Imaging studies, such as CT or MRI scans, may be used to rule out other conditions and to evaluate the extent of brain damage.

Treatment of meningitis depends on the cause of the infection and may include antibiotics, antiviral medications, antifungal medications, or supportive care to manage symptoms and prevent complications. Supportive care may include intravenous fluids, oxygen therapy, and pain management. In severe cases, meningitis may require hospitalization in an intensive care unit (ICU) and may result in long-term consequences such as hearing loss, learning disabilities, or cognitive impairment.

Prevention of meningitis includes vaccination against the bacteria or viruses that can cause the infection, good hygiene practices, and avoiding close contact with people who are sick. Vaccines are available for certain types of meningitis, such as the meningococcal conjugate vaccine (MenACWY) and the pneumococcal conjugate vaccine (PCV). Good hygiene practices include washing hands frequently, covering the mouth and nose when coughing or sneezing, and avoiding sharing food, drinks, or personal items.

In conclusion, meningitis is a serious and potentially life-threatening infection that can affect people of all ages. Early diagnosis and treatment are crucial to prevent long-term consequences and improve outcomes. Prevention includes vaccination, good hygiene practices, and avoiding close contact with people who are sick.



Symptoms of bacterial meningitis may include sudden onset of fever, headache, stiff neck, nausea, vomiting, and sensitivity to light. In severe cases, the infection can cause seizures, coma, and even death.

Bacterial meningitis can be diagnosed through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans. Treatment typically involves antibiotics to eradicate the infection, and supportive care to manage symptoms and prevent complications.

Early diagnosis and treatment are critical to prevent long-term damage and improve outcomes for patients with bacterial meningitis. The disease is more common in certain groups, such as infants, young children, and people with weakened immune systems, and it can be more severe in these populations.

Prevention of bacterial meningitis includes vaccination against the bacteria that most commonly cause the disease, good hand hygiene, and avoiding close contact with people who are sick.

Definition: Meningitis, pneumococcal, is an inflammatory disease caused by Streptococcus pneumoniae (pneumococcus) that affects the protective membranes (meninges) covering the brain and spinal cord, leading to a range of symptoms including fever, headache, vomiting, and altered mental status. It can be a severe and potentially life-threatening infection, particularly in certain patient populations such as children under 5 years old, older adults, and those with underlying medical conditions.

Epidemiology: Pneumococcal meningitis is relatively uncommon, but it remains an important public health concern, particularly in developed countries. According to the Centers for Disease Control and Prevention (CDC), there are approximately 350 cases of pneumococcal meningitis reported each year in the United States, resulting in about 10% of all cases of bacterial meningitis.

Risk Factors: Several risk factors have been identified for developing pneumococcal meningitis, including:

1. Age: Children under 5 years old and older adults are at increased risk.
2. Underlying medical conditions: Patients with conditions such as sickle cell disease, HIV/AIDS, and chronic lung disease are more likely to develop pneumococcal meningitis.
3. Weakened immune system: Those with compromised immune systems, such as those taking immunosuppressive medications or who have undergone organ transplants, are at higher risk.
4. Recent exposure to someone with pneumococcal disease: Close contact with someone who has recently been diagnosed with pneumococcal disease can increase the risk of developing the infection.

Clinical Presentation: Symptoms of pneumococcal meningitis can vary depending on the age of the patient, but common presentations include:

1. Fever
2. Headache
3. Vomiting
4. Altered mental status (in infants and young children) or confusion (in older adults)
5. Stiff neck
6. Sensitivity to light (photophobia)
7. Bulging of the soft spots on the skull in infants (in infants)

Diagnosis: The diagnosis of pneumococcal meningitis is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include blood cultures, cerebrospinal fluid (CSF) cultures, and polymerase chain reaction (PCR) to detect the presence of S. pneumoniae. Imaging studies, such as CT or MRI scans, may be used to evaluate the brain and identify any signs of inflammation or abscesses.

Treatment: Pneumococcal meningitis is typically treated with antibiotics, which are usually given intravenously. The choice of antibiotic depends on the severity of the infection and the patient's age and medical history. In addition to antibiotics, supportive care may be provided to manage symptoms such as fever, headache, and muscle aches. In severe cases, hospitalization may be necessary to monitor and treat the infection.

Complications: Pneumococcal meningitis can lead to serious complications, including:

1. Hearing loss
2. Learning disabilities
3. Behavioral changes
4. Seizures
5. Brain damage
6. Death

Prevention: Pneumococcal conjugate vaccine (PCV) is recommended for children under the age of 2 years and for certain high-risk groups, such as adults over the age of 65 and people with certain medical conditions. The vaccine can help prevent pneumococcal meningitis and other serious infections caused by S. pneumoniae. Good hygiene practices, such as frequent handwashing, can also help prevent the spread of the bacteria.

Prognosis: With prompt and appropriate treatment, the prognosis for pneumococcal meningitis is generally good. However, in severe cases or those with complications, the prognosis may be poorer. In some cases, long-term sequelae such as hearing loss, learning disabilities, and behavioral changes may occur.

Incubation period: The incubation period for pneumococcal meningitis is typically between 2 and 4 days, but it can range from 1 to 10 days.

Diagnosis: Pneumococcal meningitis is diagnosed based on a combination of clinical symptoms, physical examination findings, laboratory tests, and imaging studies such as CT or MRI scans. Laboratory tests may include blood cultures, cerebrospinal fluid (CSF) analysis, and PCR testing to identify the presence of S. pneumoniae.

Treatment: Treatment for pneumococcal meningitis typically involves antibiotics and supportive care to manage symptoms such as fever, headache, and muscle aches. In severe cases, hospitalization may be necessary to monitor and treat the infection.

In conclusion, pneumococcal meningitis is a serious infection that can cause significant morbidity and mortality. Prompt diagnosis and appropriate treatment are essential to prevent long-term sequelae and improve outcomes for affected individuals.

Symptoms of meningococcal meningitis typically develop within 3-7 days after exposure and may include fever, headache, stiff neck, confusion, nausea and vomiting, sensitivity to light, and seizures. In severe cases, the infection can lead to shock, organ failure, and death within hours of the onset of symptoms.

Diagnosis is typically made by a combination of physical examination, laboratory tests (such as blood cultures and PCR), and imaging studies (such as CT or MRI scans). Treatment typically involves antibiotics, intravenous fluids, and supportive care to manage fever, pain, and other symptoms. In severe cases, hospitalization in an intensive care unit may be necessary.

Prevention of meningococcal meningitis includes the use of vaccines, good hygiene practices (such as frequent handwashing), and avoidance of close contact with people who are sick. A vaccine is available for children and teens, and some colleges and universities require students to be vaccinated before moving into dorms.

Early diagnosis and treatment are crucial in preventing long-term complications and reducing the risk of death from meningococcal meningitis. If you suspect that you or someone else may have meningococcal meningitis, it is important to seek medical attention immediately.

* Earache (otalgia)
* Fever
* Hearing loss or muffled hearing
* Discharge from the ear
* Redness and swelling around the ear drum
* Fussiness or irritability in infants
* Loss of appetite or difficulty eating
* Difficulty sleeping

Otitis media is caused by a virus or bacteria that enters the middle ear through the Eustachian tube, which connects the back of the throat to the middle ear. The infection can spread quickly and cause inflammation in the middle ear, leading to hearing loss and other symptoms.

There are several types of otitis media, including:

* Acute otitis media: This is a sudden and severe infection that can develop over a few days. It is usually caused by a bacterial infection and can be treated with antibiotics.
* Otitis media with effusion (OME): This is a condition where fluid accumulates in the middle ear without an infection present. It can cause hearing loss and other symptoms but does not respond to antibiotics.
* Chronic suppurative otitis media (CSOM): This is a long-term infection that can cause persistent discharge, hearing loss, and other symptoms. It may require ongoing treatment with antibiotics and other therapies.

Otitis media can be diagnosed through a physical examination of the ear and a review of the patient's medical history. A doctor may also use tests such as a tympanocentesis (insertion of a small tube into the ear to collect fluid) or an otoscopic exam to confirm the diagnosis.

Treatment for otitis media depends on the type and severity of the infection, but may include:

* Antibiotics: To treat bacterial infections
* Pain relief medication: To help manage ear pain and fever
* Eardrops: To help clear fluid from the middle ear and reduce discharge
* Tympanocentesis: To collect fluid from the middle ear for testing or to relieve pressure
* Ventilation tubes: Small tubes that are inserted into the ear drum to allow air to enter the middle ear and help drain fluid.

It is important to seek medical attention if symptoms of otitis media persist or worsen over time, as untreated infections can lead to complications such as mastoiditis (an infection of the bones behind the ear) or meningitis (an infection of the lining around the brain and spinal cord). With prompt and appropriate treatment, however, most cases of otitis media can be effectively managed and hearing loss can be prevented.

Here are some key points to define sepsis:

1. Inflammatory response: Sepsis is characterized by an excessive and uncontrolled inflammatory response to an infection. This can lead to tissue damage and organ dysfunction.
2. Systemic symptoms: Patients with sepsis often have systemic symptoms such as fever, chills, rapid heart rate, and confusion. They may also experience nausea, vomiting, and diarrhea.
3. Organ dysfunction: Sepsis can cause dysfunction in multiple organs, including the lungs, kidneys, liver, and heart. This can lead to organ failure and death if not treated promptly.
4. Infection source: Sepsis is usually caused by a bacterial infection, but it can also be caused by fungal or viral infections. The infection can be localized or widespread, and it can affect different parts of the body.
5. Severe sepsis: Severe sepsis is a more severe form of sepsis that is characterized by severe organ dysfunction and a higher risk of death. Patients with severe sepsis may require intensive care unit (ICU) admission and mechanical ventilation.
6. Septic shock: Septic shock is a life-threatening condition that occurs when there is severe circulatory dysfunction due to sepsis. It is characterized by hypotension, vasopressor use, and organ failure.

Early recognition and treatment of sepsis are critical to preventing serious complications and improving outcomes. The Sepsis-3 definition is widely used in clinical practice to diagnose sepsis and severe sepsis.

The symptoms of tetanus can develop anywhere from 3 days to 3 weeks after exposure to the bacteria, and they can include:

* Muscle stiffness and spasms, especially in the neck, jaw, and limbs
* Difficulty swallowing or speaking
* Fever and sweating
* Headache and fatigue
* Rigidity and spasticity of muscles
* Abdominal cramps and diarrhea
* In severe cases, tetanus can cause serious complications such as pneumonia, heart problems, and death.

Tetanus is diagnosed through a physical examination, medical history, and laboratory tests. Treatment typically involves administering antitoxin medication to neutralize the effects of the bacterial toxins, as well as providing supportive care such as pain management and wound care.

Prevention is key in avoiding tetanus, and this can be achieved through:

* Vaccination: Tetanus vaccines are available and recommended for individuals of all ages, especially for those who have open wounds or injuries.
* Proper wound care: Keeping wounds clean and covered can help prevent the entry of bacteria into the body.
* Avoiding risky behaviors: Avoiding activities that can cause injury, such as playing contact sports or engaging in dangerous hobbies, can reduce the risk of developing tetanus.

Overall, tetanus is a serious medical condition that requires prompt treatment and prevention measures to avoid complications and ensure a full recovery.

The cause of panophthalmitis is often related to bacterial infections, such as endophthalmitis, which is an infection within the eyeball, or orbital cellulitis, which is an infection of the tissues surrounding the eye. Other causes may include trauma to the eye, foreign body lodged in the eye, or systemic infections such as meningitis or sepsis.

Symptoms of panophthalmitis may include:

* Severe pain and redness of the eye
* Swelling of the eyelids and eye ball
* Sensitivity to light
* Blurred vision or vision loss
* Fever, chills, and general feeling of being unwell
* Difficulty moving the eyes or facial paralysis

Diagnosis of panophthalmitis is based on a combination of physical examination, medical history, and laboratory tests such as blood cultures, PCR, and imaging studies like CT or MRI.

Treatment of panophthalmitis usually involves antibiotics to combat any underlying infection, and management of symptoms such as pain and inflammation. In some cases, surgical intervention may be necessary to drain abscesses or remove foreign bodies from the eye.

Prognosis for panophthalmitis is generally poor, with a high risk of complications such as blindness, cranial nerve palsies, and extracapsular cataract formation. Prompt treatment and management are essential to prevent further damage and improve outcomes.

The symptoms of diphtheria typically develop within 2-5 days after exposure and may include:

* Sore throat and difficulty swallowing
* Fever and chills
* Swollen and tender lymph nodes in the neck
* Difficulty breathing or shortness of breath
* Skin lesions or rashes
* Nerve damage, leading to weakness, paralysis, and other neurological symptoms.

If left untreated, diphtheria can lead to serious complications such as respiratory failure, heart failure, and death. Treatment typically involves antibiotics, which can help clear the infection and prevent further damage. In severe cases, hospitalization may be required to provide supportive care, such as mechanical ventilation or cardiac support.

Diphtheria is a vaccine-preventable disease, and immunization programs have been instrumental in reducing the incidence of this disease worldwide. However, outbreaks still occur in some areas, particularly among unvaccinated individuals or those living in areas with low vaccination coverage.

In addition to its clinical features, diphtheria has several key characteristics that are important to note:

* It is highly contagious and can be transmitted through respiratory droplets, close contact with an infected person, or by touching contaminated surfaces and objects.
* The bacteria can survive for weeks outside the body, making it a significant risk for transmission through fomites.
* Immunity to diphtheria is not lifelong, and booster doses of the vaccine are recommended every 10 years to maintain protection.

Types of Pneumococcal Infections:

1. Pneumonia: This is an infection of the lungs that can cause fever, cough, chest pain, and difficulty breathing.
2. Meningitis: This is an infection of the membranes that cover the brain and spinal cord, which can cause fever, headache, stiff neck, and confusion.
3. Septicemia (bloodstream infection): This is an infection of the blood that can cause fever, chills, and low blood pressure.
4. Sinusitis: This is an infection of the sinuses, which can cause headache, facial pain, and difficulty breathing through the nose.
5. Otitis media (middle ear infection): This is an infection of the middle ear, which can cause ear pain, fever, and hearing loss.

Causes and Risk Factors:

Pneumococcal infections are caused by the bacteria Streptococcus pneumoniae. These bacteria can be spread through close contact with an infected person, such as touching or sharing food and drinks. People who are at high risk for developing pneumococcal infections include:

1. Children under the age of 5 and adults over the age of 65.
2. People with weakened immune systems, such as those with cancer, HIV/AIDS, or taking medications that suppress the immune system.
3. Smokers and people with chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease (COPD).
4. People who have recently had surgery or have a severe injury.
5. Those who live in long-term care facilities or have limited access to healthcare.

Prevention and Treatment:

Preventing pneumococcal infections is important, especially for high-risk individuals. Here are some ways to prevent and treat pneumococcal infections:

1. Vaccination: The pneumococcal conjugate vaccine (PCV) is recommended for children under the age of 5 and adults over the age of 65, as well as for people with certain medical conditions.
2. Hand washing: Frequent hand washing can help prevent the spread of pneumococcal bacteria.
3. Good hygiene: Avoiding close contact with people who are sick and regularly cleaning surfaces that may be contaminated with bacteria can also help prevent infection.
4. Antibiotics: Pneumococcal infections can be treated with antibiotics, but overuse of antibiotics can lead to the development of antibiotic-resistant bacteria. Therefore, antibiotics should only be used when necessary and under the guidance of a healthcare professional.
5. Supportive care: Those with severe pneumococcal infections may require hospitalization and supportive care, such as oxygen therapy or mechanical ventilation.

Conclusion:

Pneumococcal infections can be serious and even life-threatening, especially for high-risk individuals. Prevention and prompt treatment are key to reducing the risk of complications and improving outcomes. Vaccination, good hygiene practices, and appropriate antibiotic use are all important in preventing and treating pneumococcal infections. If you suspect that you or a loved one has a pneumococcal infection, it is essential to seek medical attention right away. With proper care and support, many people with pneumococcal infections can recover fully and resume their normal lives.

The most common bacteria that cause pneumonia are Streptococcus pneumoniae (also known as pneumococcus), Haemophilus influenzae, and Staphylococcus aureus. These bacteria can infect the lungs through various routes, including respiratory droplets, contaminated food or water, or direct contact with an infected person.

Symptoms of pneumonia may include cough, fever, chills, shortness of breath, and chest pain. In severe cases, pneumonia can lead to serious complications such as respiratory failure, sepsis, and death.

Diagnosis of pneumonia typically involves a physical examination, medical history, and diagnostic tests such as chest X-rays or blood cultures. Treatment typically involves antibiotics to eliminate the infection, as well as supportive care to manage symptoms and prevent complications. Vaccines are also available to protect against certain types of bacterial pneumonia, particularly in children and older adults.

Preventative measures for bacterial pneumonia include:

* Getting vaccinated against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib)
* Practicing good hygiene, such as washing hands regularly and covering the mouth and nose when coughing or sneezing
* Avoiding close contact with people who are sick
* Staying hydrated and getting enough rest
* Quitting smoking, if applicable
* Managing underlying medical conditions, such as diabetes or heart disease

It is important to seek medical attention promptly if symptoms of pneumonia develop, particularly in high-risk populations. Early diagnosis and treatment can help prevent serious complications and improve outcomes for patients with bacterial pneumonia.

Symptoms of pneumococcal pneumonia can include fever, cough, chest pain, shortness of breath, and difficulty breathing. In severe cases, the infection can spread to the bloodstream and cause sepsis, a life-threatening condition that requires immediate medical attention.

Pneumococcal pneumonia is most commonly seen in young children, older adults, and people with weakened immune systems, such as those with cancer, HIV/AIDS, or taking immunosuppressive medications. It is usually diagnosed through a combination of physical examination, medical history, and diagnostic tests such as chest X-rays and blood cultures.

Treatment of pneumococcal pneumonia typically involves antibiotics to eliminate the bacterial infection. In severe cases, hospitalization may be necessary to provide oxygen therapy, fluid replacement, and other supportive care. Vaccines are also available to prevent Streptococcus pneumoniae infections, particularly in children and older adults.

Prevention measures for pneumococcal pneumonia include:

* Vaccination: The pneumococcal conjugate vaccine (PCV) is recommended for children under the age of 2 and older adults over the age of 65, as well as for people with certain medical conditions.
* Good hygiene: Regular handwashing and avoiding close contact with people who are sick can help prevent the spread of the infection.
* Avoiding smoking: Smoking can damage the lungs and increase the risk of infection.
* Keeping up-to-date on recommended vaccinations: Staying current on recommended vaccinations, such as the flu shot, can help prevent secondary bacterial infections like pneumococcal pneumonia.
* Managing underlying conditions: People with certain medical conditions, such as diabetes or chronic lung disease, should work with their healthcare provider to manage their condition and reduce their risk of developing pneumococcal pneumonia.

It's important to seek medical attention right away if you or someone you know is experiencing symptoms of pneumococcal pneumonia, as early treatment can help prevent complications and improve outcomes.

Bacteremia can occur when bacteria enter the bloodstream through various means, such as:

* Infected wounds or surgical sites
* Injecting drug use
* Skin infections
* Respiratory tract infections
* Urinary tract infections
* Endocarditis (infection of the heart valves)

The symptoms of bacteremia can vary depending on the type of bacteria and the severity of the infection. Some common symptoms include:

* Fever
* Chills
* Headache
* Muscle aches
* Weakness
* Confusion
* Shortness of breath

Bacteremia is diagnosed by blood cultures, which involve collecting blood samples and inserting them into a specialized container to grow the bacteria. Treatment typically involves antibiotics and supportive care, such as intravenous fluids and oxygen therapy. In severe cases, hospitalization may be necessary to monitor and treat the infection.

Prevention measures for bacteremia include:

* Practicing good hygiene, such as washing hands regularly
* Avoiding sharing personal items like toothbrushes or razors
* Properly cleaning and covering wounds
* Getting vaccinated against infections that can lead to bacteremia
* Following proper sterilization techniques during medical procedures

Overall, bacteremia is a serious condition that requires prompt medical attention to prevent complications and ensure effective treatment.

1. Platelet disorders: These include conditions such as idiopathic thrombocytopenic purpura (ITP), where the immune system attacks and destroys platelets, leading to a low platelet count and bleeding symptoms.
2. Von Willebrand disease: This is a bleeding disorder caused by a deficiency of von Willebrand factor, a protein that helps platelets stick together and form clots.
3. Hemophilia A and B: These are genetic disorders that affect the blood's ability to clot and stop bleeding.
4. Vitamin K-dependent bleeding disorders: These include conditions such as vitamin K-dependent coagulopathy, which is caused by a deficiency of vitamin K and leads to abnormal clotting and bleeding.
5. Other causes: Purpura can also be caused by other medical conditions, such as liver disease, kidney disease, and certain medications.

The symptoms of purpura can vary depending on the underlying cause, but may include:

* Easy bruising (especially on the skin and joints)
* Petechiae (small red or purple spots on the skin)
* Prolonged bleeding from injuries or surgical sites
* Nosebleeds
* Gingival bleeding (bleeding from the gums)
* Heavy menstrual periods
* Bleeding into joints and muscles

If you suspect that you or someone else may have purpura, it is important to seek medical attention as soon as possible. A healthcare professional will perform a physical examination and order laboratory tests to determine the underlying cause of the bleeding disorder. Treatment for purpura depends on the specific cause, but may include medications to increase platelet count or clotting factor, or surgery to correct an underlying condition.

Some common examples of bacterial infections include:

1. Urinary tract infections (UTIs)
2. Respiratory infections such as pneumonia and bronchitis
3. Skin infections such as cellulitis and abscesses
4. Bone and joint infections such as osteomyelitis
5. Infected wounds or burns
6. Sexually transmitted infections (STIs) such as chlamydia and gonorrhea
7. Food poisoning caused by bacteria such as salmonella and E. coli.

In severe cases, bacterial infections can lead to life-threatening complications such as sepsis or blood poisoning. It is important to seek medical attention if symptoms persist or worsen over time. Proper diagnosis and treatment can help prevent these complications and ensure a full recovery.

The common types of RTIs include:

1. Common cold: A viral infection that affects the upper respiratory tract, causing symptoms such as runny nose, sneezing, coughing, and mild fever.
2. Influenza (flu): A viral infection that can affect both the upper and lower respiratory tract, causing symptoms such as fever, cough, sore throat, and body aches.
3. Bronchitis: An inflammation of the bronchial tubes, which can be caused by viruses or bacteria, resulting in symptoms such as coughing, wheezing, and shortness of breath.
4. Pneumonia: An infection of the lungs that can be caused by bacteria, viruses, or fungi, leading to symptoms such as fever, chills, coughing, and difficulty breathing.
5. Tonsillitis: An inflammation of the tonsils, which can be caused by bacteria or viruses, resulting in symptoms such as sore throat, difficulty swallowing, and bad breath.
6. Sinusitis: An inflammation of the sinuses, which can be caused by viruses, bacteria, or fungi, leading to symptoms such as headache, facial pain, and nasal congestion.
7. Laryngitis: An inflammation of the larynx (voice box), which can be caused by viruses or bacteria, resulting in symptoms such as hoarseness, loss of voice, and difficulty speaking.

RTIs can be diagnosed through physical examination, medical history, and diagnostic tests such as chest X-rays, blood tests, and nasal swab cultures. Treatment for RTIs depends on the underlying cause and may include antibiotics, antiviral medications, and supportive care to manage symptoms.

It's important to note that RTIs can be contagious and can spread through contact with an infected person or by touching contaminated surfaces. Therefore, it's essential to practice good hygiene, such as washing hands frequently, covering the mouth and nose when coughing or sneezing, and avoiding close contact with people who are sick.

Symptoms of chancroid include:

1. Painful ulcers on the genitalia, anus, or mouth
2. Swollen lymph nodes in the groin
3. Fever
4. Headache
5. Fatigue
6. Painful urination

Diagnosis of chancroid is based on physical examination and laboratory tests, such as a wet preparation or culture. Treatment involves antibiotics, and early treatment can help prevent complications. It is important to seek medical attention if symptoms persist or worsen over time. Prevention strategies include safe sex practices, such as using condoms, and regular testing for sexually transmitted infections.

Note: Chancroid is a relatively rare infection in developed countries, but it is still important to be aware of the risk factors and symptoms, especially if you have multiple sexual partners or engage in unprotected sex.

Symptoms of whooping cough typically appear within 7-14 days after exposure and may include:

* Mild fever
* Runny nose
* Sneezing
* Dry, irritating cough that progresses to spasmodic, convulsive coughing fits
* Vomiting after coughing
* Apnea (pause in breathing)

In infants, the symptoms may be milder and include:

* Mild fever
* Lack of appetite
* Irritability
* Cyanosis (blue discoloration of the skin)

If left untreated, whooping cough can lead to serious complications such as pneumonia, seizures, and brain damage. Diagnosis is based on a combination of clinical findings, laboratory tests, and medical imaging. Treatment typically involves antibiotics and supportive care to manage symptoms and prevent complications.

Prevention measures include immunization with the pertussis vaccine, which is routinely given to infants and children in early childhood, as well as booster shots during adolescence and adulthood. Good hygiene practices, such as frequent handwashing and avoiding close contact with people who are sick, can also help prevent the spread of the disease.

Symptoms of pneumonia may include cough, fever, chills, difficulty breathing, and chest pain. In severe cases, pneumonia can lead to respiratory failure, sepsis, and even death.

There are several types of pneumonia, including:

1. Community-acquired pneumonia (CAP): This type of pneumonia is caused by bacteria or viruses and typically affects healthy people outside of hospitals.
2. Hospital-acquired pneumonia (HAP): This type of pneumonia is caused by bacteria or fungi and typically affects people who are hospitalized for other illnesses or injuries.
3. Aspiration pneumonia: This type of pneumonia is caused by food, liquids, or other foreign matter being inhaled into the lungs.
4. Pneumocystis pneumonia (PCP): This type of pneumonia is caused by a fungus and typically affects people with weakened immune systems, such as those with HIV/AIDS.
5. Viral pneumonia: This type of pneumonia is caused by viruses and can be more common in children and young adults.

Pneumonia is typically diagnosed through a combination of physical examination, medical history, and diagnostic tests such as chest X-rays or blood tests. Treatment may involve antibiotics, oxygen therapy, and supportive care to manage symptoms and help the patient recover. In severe cases, hospitalization may be necessary to provide more intensive care and monitoring.

Prevention of pneumonia includes vaccination against certain types of bacteria and viruses, good hygiene practices such as frequent handwashing, and avoiding close contact with people who are sick. Early detection and treatment can help reduce the risk of complications and improve outcomes for those affected by pneumonia.

Moraxellaceae infections are typically caused by the bacteria entering the body through a break in the skin or mucous membranes, such as during a cut or scratch. Once inside the body, the bacteria can multiply and cause inflammation and damage to surrounding tissues.

The symptoms of Moraxellaceae infections can vary depending on the location and severity of the infection. Some common symptoms include:

* Fever
* Cough
* Shortness of breath
* Chest pain
* Skin redness and swelling
* Pus-filled abscesses or boils

Moraxellaceae infections can be diagnosed through a variety of tests, including blood cultures, respiratory secretion testing, and skin scrapings. Treatment typically involves antibiotics to kill the bacteria and clear up the infection. In severe cases, hospitalization may be necessary to provide more intensive treatment and monitoring.

Preventing Moraxellaceae infections can be challenging, but some steps that can help include:

* Practicing good hygiene, such as washing your hands regularly and avoiding close contact with people who are sick
* Avoiding sharing personal items, such as towels or razors, with others
* Covering wounds and cuts to prevent bacteria from entering the body
* Keeping vaccinations up to date, as some types of Moraxellaceae infections can be prevented by vaccination.

Overall, Moraxellaceae infections can be serious and potentially life-threatening, so it's important to seek medical attention if you suspect that you or someone else may have an infection. With prompt and appropriate treatment, however, most people with Moraxellaceae infections can recover fully.

Ear Anatomy: The middle ear consists of three small bones called ossicles (the malleus, incus, and stapes) that transmit sound waves to the inner ear. The eardrum, a thin membrane, separates the outer ear canal from the middle ear. In OME, fluid accumulates in the middle ear, causing the eardrum to become congested and reducing its ability to vibrate properly.

Causes: There are several factors that can contribute to the development of OME, including:

1. Viral upper respiratory infections (such as the common cold)
2. Allergies
3. Enlarged adenoids or tonsils
4. Cystic fibrosis
5. Sinus infections
6. Meniere's disease
7. Head injury

Symptoms: The symptoms of OME can vary depending on the severity of the condition, but may include:

1. Hearing loss or muffled hearing
2. Discharge or fluid leaking from the ear
3. Pain or discomfort in the ear
4. Difficulty responding to sounds or understanding speech
5. Fever
6. Headache
7. Vertigo or dizziness
8. Loss of balance or coordination

Diagnosis: OME is typically diagnosed through a combination of physical examination, medical history, and ear examinations using an otoscope or tympanometry. A tympanogram may also be performed to measure the movement of the eardrum.

Treatment: The treatment of OME depends on the severity of the condition and may include:

1. Watchful waiting: In mild cases, OME may resolve on its own within a few weeks without any treatment.
2. Antibiotics: If there is a concurrent infection, antibiotics may be prescribed to treat the underlying infection.
3. Pain relief medication: Over-the-counter pain relief medication such as acetaminophen or ibuprofen may be recommended to relieve any discomfort or pain.
4. Eardrops: Eardrops containing antibiotics or steroids may be prescribed to treat the infection and reduce inflammation.
5. Tubes in the ear: In more severe cases, tubes may be placed in the ear drum to help drain fluid and relieve pressure.
6. Surgery: In rare cases, surgery may be necessary to remove the membrane or repair any damage to the middle ear bones.

Prognosis: The prognosis for OME is generally good, with most cases resolving within a few weeks without any long-term complications. However, in some cases, the condition can persist for longer periods of time and may lead to more serious complications such as hearing loss or mastoiditis.

Prevention: There is no specific way to prevent OME, but good ear hygiene and avoiding exposure to loud noises can help reduce the risk of developing the condition. Regular check-ups with an audiologist or otolaryngologist can also help identify any early signs of OME and prevent complications.

Conclusion: Otitis media with effusion (OME) is a common condition that affects children and adults, causing fluid buildup in the middle ear. While it is generally not a serious condition, it can cause discomfort and affect hearing. Treatment options range from watchful waiting to antibiotics and surgery, depending on the severity of the case. Good ear hygiene and regular check-ups with an audiologist or otolaryngologist can help prevent complications and ensure proper management of the condition.

"Haemophilus influenzae". NCBI Taxonomy Browser. 727. Type strain of Haemophilus influenzae at BacDive - the Bacterial Diversity ... The six generally recognized types of encapsulated H. influenzae are: a, b, c, d, e, and f. H. Influenzae type b, also known as ... "Haemophilus influenzae type B (HiB)". Health Topics A to Z. Retrieved 2011-03-29. Jin Z, Romero-Steiner S, Carlone GM, Robbins ... Haemophilus influenzae (Hib) , CDC". www.cdc.gov. 2022-09-22. Retrieved 2022-10-13. "Symptoms of Haemophilus influenzae , CDC ...
Haemophilus influenzae). Similar sequences, called DNA uptake sequences (DUS), are found in species of the family Neisseriaceae ... Specific recognition of DUSs is mediated by a type IV pilin. Davidsen et al. reported that in N. meningitidis DUSs occur at a ... "Specific DNA recognition mediated by a type IV pilin". Proc. Natl. Acad. Sci. U.S.A. 110 (8): 3065-70. Bibcode:2013PNAS.. ...
Haemophilus influenzae type b; respiratory syncytial virus and influenza vaccines. She has worked extensively with American ...
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This approach is used in the Haemophilus influenzae type B vaccine. Outer membrane vesicles (OMVs) are naturally immunogenic ... Haemophilus influenzae type b). Likewise, a recombinant protein derived from the viruses or bacteria can be generated in yeast ... "Different Types of Vaccines , History of Vaccines". www.historyofvaccines.org. Retrieved 2019-06-14. "Different Types of ... There are several types of vaccines in use. These represent different strategies used to try to reduce the risk of illness ...
The Haemophilus influenzae type B vaccine, also known as Hib vaccine, is a vaccine used to prevent Haemophilus influenzae type ... Haemophilus influenzae type b (Hib)". Immunisation against infectious disease. Public Health England. "Haemophilus Influenzae ... However, non-type B disease is rare in comparison to pre-vaccine rates of Haemophilus influenzae type B disease.[citation ... "Haemophilus b Conjugate Vaccines for Prevention of Haemophilus influenzae Type b Disease Among Infants and Children Two Months ...
18.1%), and Haemophilus influenzae (4.9%). Viral pneumonia: influenza and respiratory syncytial virus and, in the ... usually of the MRSA type. Others are Haemophilus spp. (5%). In the ICU results were S. aureus (17.4%), Pseudomonas aeruginosa ( ... Haemophilus influenzae, and methicillin-sensitive S. aureus should also be considered. Pneumonia that starts in the hospital ... and less Streptococcus pneumoniae and Haemophilus influenzae. In European and Asian studies, the etiology of HCAP was similar ...
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Haemophilus influenzae and Chlamydia trachomatis are coccobacilli. Aggregatibacter actinomycetemcomitans is a gram negative ... A coccobacillus (plural coccobacilli) is a type of rod-shaped bacteria. The word coccobacillus reflects an intermediate shape ... Important human diseases caused by coccoid bacteria include staphylococcal infections, some types of food poisoning, some ...
"CDC: Haemophilus influenzae Type B". Retrieved 10 Oct 2021. "FDA: Pneumococcusus" (PDF). Food and Drug Administration. ... "Haemophilus influenzae Disease (Including Hib) Signs and Symptoms". CDC. CDC. Retrieved 10 April 2014. "Haemophilus influenzae ... "About Haemophilus influenzae Disease". CDC. CDC. Retrieved 10 April 2014. "Haemophilus influenzae Disease (Including Hib) ... Haemphilus Influenza Type B is caused by the bacteria Haemophilus influenzae. This can cause severe infection which occurs ...
Morris SK, Moss WJ, Halsey NA (Jul 2008). "Haemophilus influenzae type b conjugate vaccine use and effectiveness". Lancet ... Haemophilus influenzae type B, tetanus, Lyme disease, rotavirus, Argentina Hemorrhagic Fever, human papillomavirus (HPV) and ... "Differences in the immune response to hepatitis B and Haemophilus influenzae type b vaccines in Guatemalan infants by ethnic ... "Differences in the immune response to hepatitis B and Haemophilus influenzae type b vaccines in Guatemalan infants by ethnic ...
Haemophilus influenzae, Gardnerella vaginalis, and Chlamydia trachomatis are coccobacilli. Aggregatibacter ... A coccobacillus (plural coccobacilli), or bacilluscocco, is a type of bacterium with a shape intermediate between cocci ( ... Haemophilus ducreyi, another medically important Gram-negative coccobacillus, is observed in sexually transmitted disease, ...
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Haemophilus influenzae type b vaccine, especially if not received in childhood. For adults who have not been previously ... In particular, patients are at risk from Streptococcus pneumoniae, Haemophilus influenzae, and meningococcus. The risk is ... becoming infected with encapsulated bacteria such as Haemophilus influenzae, Streptococcus pneumoniae and Neisseria ... There are two distinct types of genetic disorders: heterotaxy syndrome and isolated congenital asplenia. polysplenia Acquired ...
"Decline of bone and joint infections attributable to haemophilus influenzae type b". Clin. Orthop. Relat. Res. (341): 128-133. ... "Reduced incidence of septic arthritis in children by Haemophilus influenzae type-b vaccination. Implications for treatment". J ... a common cause in infants Haemophilus influenzae Neisseria gonorrhoeae - the most common cause of septic arthritis in young, ...
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in Haemophilus influenzae and identified as a novel type of glycosyltransferase in 2010. The Actinobacillus pleuropneumoniae N- ... Haemophilus influenzae has an additional HMW1C homologue HMW2C, which together with the adhesin HMW2 forms a similar substrate- ... In Haemophilus influenzae (a respiratory tract pathogen), the N-glycosyltransferase HMW1C attaches galactose and glucose taken ... The Haemophilus influenzae N-glycosyltransferase has domains with homologies to glutathione S-transferase and glycogen synthase ...
"Invasive Haemophilus influenzae type b diseases in Bangladesh, with increased resistance to antibiotics". The Journal of ... "Impact of introduction of the Haemophilus influenzae type b conjugate vaccine into childhood immunization on meningitis in ... The surveillance data is generated on invasive childhood diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, ...
... and Haemophilus influenzae type b conjugate vaccine impact on pneumonia in the Gambia; creation of funded population based ...
This was the Haemophilus influenzae type b (Hib) conjugate, which protects against meningitis. The vaccine was soon ... A conjugate vaccine is a type of subunit vaccine which combines a weak antigen with a strong antigen as a carrier so that the ... when the immune response to the Streptococcus pneumoniae type 3 polysaccharide antigen was increased by combining the ...
"Introduction of Haemophilus Influenzae type b (Hib) as Pentavalent (DPT-HepB-Hib) Vaccine in Two States of India". Indian ... "NTAGI subcommittee recommendations on Haemophilus influenzae type B (Hib) vaccine introduction in India" (PDF). Indian ... and on the introduction of Haemophilus influenza type b (Hib)vaccine as well as scale up of Hepatitis B vaccine across the ...
McKinney WP, Agner RC (December 1989). "Waterhouse-Friderichsen syndrome caused by Haemophilus influenzae type b in an ... It can also be associated with Haemophilus influenzae. Viruses may also be implicated in adrenal problems: Cytomegalovirus can ... "Waterhouse-Friderichsen syndrome without purpura due to Haemophilus influenzae group B". Postgrad Med J. 61 (711): 67-8. doi: ...
Karvonen, M.; Cepaitis, Z.; Tuomilehto, J. (1999). "Association between type 1 diabetes and Haemophilus influenzae type b ... causing an autoimmune state leading to immune-mediated type 1 diabetes, and he is quoted on many anti-vaccine websites, such as ... and Risk of Type 1 Diabetes Mellitus". Pediatrics. 108 (6): e112. doi:10.1542/peds.108.6.e112. PMID 11731639. ... "did not find an increased risk of type 1 diabetes associated with any of the routinely recommended childhood vaccines." ...
Vaccination of infants against Haemophilus influenzae type B began in 1988 and led to a dramatic decline in cases shortly ... "Decline of childhood Haemophilus influenzae type b (Hib) disease in the Hib vaccine era". JAMA. 269 (2): 221-6. doi:10.1001/ ... Vaccinations against Haemophilus influenzae and Streptococcus pneumoniae have good evidence to support their use. There is ... Other commonly isolated bacteria include Haemophilus influenzae in 20%, Chlamydophila pneumoniae in 13%, and Mycoplasma ...
"Haemophilus aegyptius bacteremia in Brazilian purpuric fever." Lancet ii (1987): 761-3. Type strain of Haemophilus influenzae ... "Deoxyribonucleic acid relatedness between Haemophilus aegyptius and Haemophilus influenzae," Elsevier, 137B (1986): 155-163. ... "Biochemical, Genetic and Epidemiologic Characterization of Haemophilus influenzae Biogroup Aegyptius (Haemophilus aegyptius) ... Haemophilus influenzae biogroup aegyptius (Hae) is a causative agent of acute and often purulent conjunctivitis, more commonly ...
... microbiologist best known for developing a vaccine that protects children from infections by Haemophilus influenzae type b (Hib ...
These infections include but are not limited to Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. ... Meningococcal (a type of bacteria) infections can occur in people taking pegcetacoplan and can become life-threatening or fatal ... Two weeks before receiving pegcetacoplan, patients must receive vaccinations for pneumonia, meningitis, or influenza type B. ...
The Hia protein is a TAA found on the outer membrane of the bacterium Haemophilus influenzae. It adheres to the respiratory ... The ISneck domain is a type of neck domain. There are two types of ISneck domain. This first is an ISneck which is interrupted ... Meng G, St Geme JW, Waksman G (2008). "Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter". J ... Surana NK, Cutter D, Barenkamp SJ, St Geme JW (2004). "The Haemophilus influenzae Hia autotransporter contains an unusually ...
Common aerobic bacteria involved include: Streptococcus pneumoniae Staphylococcus aureus Haemophilus influenzae Pseudomonas ... For many types of surgical operations, people preparing for surgery are therefore instructed to take nothing by mouth (nil per ... Aspiration pneumonia is a type of lung infection that is due to a relatively large amount of material from the stomach or mouth ... Differentiating from other types of pneumonia may be difficult. Treatment is typically with antibiotics such as clindamycin, ...
Haemophilus influenzae, Neisseria meningitidis, and Escherichia coli O157:H7. He also wrote on the history of science and ... His research focused on improved bacteria typing, or "fingerprinting", methods, and led to new methods for the investigation of ...
Streptococcus pneumoniae and Haemophilus influenzae type b (Hib). Swine flu is one of many diseases that are contracted by ... Since bacteria likes wet and humid surroundings, the type of the handle - whether it is a lever or a knob - makes a difference ... around the spinal cord and brain most often caused by Viral and Bacterial infection which incidentally are the only two types ... contracting meningitis which is why recommended vaccines have been put in place across the UK for the three main bacteria types ...
In 1995 Haemophilus influenzae was genetically sequenced, a close relative to Histophilus somni and the first free living ... "Histophilus somni 8025 , Type strain , DSM 23850, ATCC 43625, CCUG 36157, MCCM 00728, CIP 108133 , BacDiveID:11751". bacdive. ... A differentiating factor between Histophilus somni and the Haemophilus species is that Histophilus species are able to grow in ... Prior to 2003, it was thought Haemophilus somnus, Histophilus ovis, and Histophilus agni were three different species, but now ...
Centers for Disease Control Prevention (CDC) (March 2002). "Progress toward elimination of Haemophilus influenzae type b ... As a more modest example, infections caused by Haemophilus influenzae (Hib), a major cause of bacterial meningitis and other ... Once such diseases (e.g., Haemophilus influenzae B) decrease in prevalence, people may no longer appreciate how serious the ... Analysis by the CDC scientists showed that the measles virus type in this outbreak (B3) was identical to the virus type that ...
Ahrén IL, Eriksson E, Egesten A, Riesbeck K (November 2003). "Nontypeable Haemophilus influenzae activates human eosinophils ... CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small ... C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. ... The C-type lectin receptors are class of signalling pattern recognition receptors which are involved in antifungal immunity, ...
Haemophilus influenzae, and Moraxella catarrhalis). These atypical organisms include special bacteria, viruses, fungi, and ... Many of the organisms causative of atypical pneumonia are unusual types of bacteria (Mycoplasma is a type of bacteria without a ... Atypical pneumonia, also known as walking pneumonia, is any type of pneumonia not caused by one of the pathogens most commonly ...
Pfeiffer as the bacteria species Haemophilus influenzae, which retains "influenza" in its name. In the following years, the ... B cells, a type of white blood cell, produce antibodies that bind to influenza antigens HA and NA (or HEF) and other proteins ... There are four types of influenza virus, termed influenza viruses A, B, C, and D. Aquatic birds are the primary source of ... There are three types of inactivated vaccines: whole virus, split virus, in which the virus is disrupted by a detergent, and ...
"Analyzing the economic value of the hepatitis B-Haemophilus influenzae type B combination vaccine by reverse engineering a ...
Green nail syndrome Group JK Corynebacterium sepsis Haemophilus influenzae cellulitis Helicobacter cellulitis Hospital ... Neurofibromatosis type 3 (neurofibromatosis mixed type) Neurofibromatosis type 4 (neurofibromatosis variant type) Neutral lipid ... Ferguson-Smith type of multiple self-healing keratoacanthomas, multiple keratoacanthomas of the Ferguson-Smith type) Multiple ... Multiple endocrine neoplasia type 3 (mucosal neuromata with endocrine tumors, multiple endocrine neoplasia type 2B, multiple ...
e (1995) Whole-genome random sequencing and assembly of Haemophilus influenzae Rd" Science 269:496-512. Prescott LM, Harley JP ... The 3 main types of media used for testing are: Solid culture: A solid surface is created using a mixture of nutrients, salts ... Haemophilus influenzae. A few months later, the first eukaryotic genome was completed. This would prove invaluable for ... Replication between viruses is greatly varied and depends on the type of genes involved in them. Most DNA viruses assemble in ...
... jejuni Capnocytophaga ochracea Corynebacterium xerosis Enterobacter cloacae Escherichia coli Haemophilus influenzae ... Mikola H, Waris M, Tenovuo J (Mar 1995). "Inhibition of herpes simplex virus type 1, respiratory syncytial virus and echovirus ... type 11 by peroxidase-generated hypothiocyanite". Antiviral Res. 26 (2): 161-71. doi:10.1016/0166-3542(94)00073-h. PMID 7605114 ...
"Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae- ... It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family ...
In the UK, IPV is combined with tetanus, diphtheria, pertussis, and Haemophilus influenzae type b vaccines. OPV is an ... type 2 poliovirus), and Saukett (type 3 poliovirus), grown in a type of monkey kidney tissue culture (Vero cell line), which ... In 1961, type 1 and 2 monovalent oral poliovirus vaccine (MOPV) was licensed, and in 1962, type 3 MOPV was licensed. In 1963, ... The bivalent OPV is more effective against types 1 and 3, but does not cover type 2. The United States as of 2017 continues to ...
In DPB, bacteria such as Haemophilus influenzae and Pseudomonas aeruginosa can cause the proliferation of inflammatory cells ... If present with DPB, the human T-lymphotropic virus, type I, a retrovirus, modifies DPB pathogenesis by infecting T helper ... The fact that inflammation in DPB persists with or without the presence of P. aeruginosa and H. influenzae provides a means to ... Bacteria such as H. influenzae and P. aeruginosa are also detectable, with the latter becoming more prominent as the disease ...
Fleming suggested that penicillin could have been used to isolate gram-negative bacteria, such as Haemophilus influenzae, which ... There are four types of members of the Medical Research Club: Honorary, Senior, Ordinary, and Non-resident. Ordinary Members ... and different types of membership are accepted, as stated in rule 2: "The Club shall consist of Honorary, Senior, Ordinary and ...
or Haemophilus influenzae, the combination of tazobactam (which shares a similar structure to sulbactam, another β-lactamase ... Some bacteria may produce certain types of β-lactamase such as AmpC, which are intrinsically resistant to tazobactam. A major ... limiting the focus down to two types of infusions; continuous and intermittent. A comparison using the two administration ...
Polio vaccines Haemophilus influenzae type b vaccines Diphtheria, tetanus and polio combined vaccines DPT, haemophilus combined ... vaccines DPT, polio combined vaccines DPT, haemophilus, polio combined vaccines DPT, haemophilus, polio, hepatitis B combined ...
Infectious vulvovaginitis can be caused by group A beta-hemolytic Streptococcus (7-20% of cases), Haemophilus influenzae, ... Another type of vaginitis, called desquamative inflammatory vaginitis (DIV) also exists. The cause behind this type is still ... Certain types of vaginitis may result in complications during pregnancy. The three main causes are infections, specifically ... Donders GG, Vereecken A, Bosmans E, Dekeersmaecker A, Salembier G, Spitz B (January 2002). "Definition of a type of abnormal ...
Haemophilus influenzae type b conjugate, Hepatitis B, with the availability varying in different countries. For the every ten- ... "Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B ... The type of vaccination for this disease is called artificial active immunity. This type of immunity is generated when a dead ... and haemophilus B conjugate vaccine and guidance for use in infants and children". MMWR Morb. Mortal. Wkly. Rep. 57 (39): 1079- ...
Haemophilus influenzae and Vibrio cholerae. It has also been studied in gram-negative species found in soil such as Pseudomonas ... Medically relevant gram-negative cocci include the four types that cause a sexually transmitted disease (Neisseria gonorrhoeae ... Haemophilus influenzae). Medically relevant gram-negative bacilli include a multitude of species. Some of them cause primarily ...
Haemophilus influenzae bacteria, including Hib, can cause many kinds of infections. These can range from mild ear infections to ... Haemophilus influenzae, a type of bacteria, can cause many different kinds of infections. These infections range from mild, ... H. influenzae can also be a common cause of ear infections in children and bronchitis in adults. Learn more about these ... Doctors consider some H. influenzae infections "invasive." Invasive disease happens when the bacteria invade parts of the body ...
Haemophilus influenzae type b (Hib) Vaccine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Hib vaccine can prevent Haemophilus influenzae type b (Hib) disease.. Haemophilus influenzae type b can cause many different ... Comvax® (containing Haemophilus influenzae type b, Hepatitis B). *MenHibrix® (containing Haemophilus influenzae type b, ... Haemophilus influenzae type b (Hib) Vaccine Information Statement. U.S. Department of Health and Human Services/Centers for ...
Haemophilus influenzae type b immunization : introducing Haemophilus influenzae type B (‎Hib)‎ conjugate vaccine into national ... Inmunización contra Haemophilus influenzae tipo b : introducción de la vacuna conjugada contra Haemophilus influenzae tipo B ... Haemophilus influenzae type b diseases in children: a pre-vaccination study  Bakir, M.; El Khadir, A.; Devadas, K.; Farrukh, A ... Healthy carriers of Haemophilus influenzae type b [‎Hib]‎ play an important role in the spread of invasive disease. The aim of ...
Haemophilus influenzae type b Conjugate Vaccine (Tetanus Toxoid Conjugate). ‡ Haemophilus influenzae type b Conjugate Vaccine ( ... Haemophilus influenzae type b Conjugate Vaccine (Tetanus Toxoid Conjugate). § Haemophilus influenzae type b Conjugate Vaccine ( ... influenzae type b disease and have been observed to have low immune responses to Haemophilus influenzae type b conjugate ... ActHIB® is a vaccine indicated for the prevention of invasive disease caused by Haemophilus influenzae (H. influenzae) type b. ...
Haemophilus influenzae type b (Hib) is bacteria that commonly cause bacterial meningitis and pneumonia and the leading cause of ... WHO position paper on Haemophilus influenzae type b vaccines Immunological basis for the Haemophilus influenzae type b vaccines ... Haemophilus influenzae type b (Hib) is bacteria that commonly causes bacterial meningitis and pneumonia and is the leading ... Global literature review of Haemophilus influenzae type b and Streptococcus pneumoniae invasive disease among children under ...
Lanes 1-5, H. influenzae type e (Hie) isolates, respectively, from patient nos. 1-5; lane 6, H. influenzae type b... ... Lanes 1-5, H. influenzae type e (Hie) isolates, respectively, from patient nos. 1-5; lane 6, H. influenzae type... ... PCR for capsular typing of Haemophilus influenzae. J Clin Microbiol. 1994;32:2382-6.PubMedGoogle Scholar ... The emergence of Haemophilus influenzae types e and f as significant pathogens. Clin Infect Dis. 1995;21:1322-4.PubMedGoogle ...
2009)‎. Global literature review of Haemophilus influenzae type b and Streptococcus pneumoniae invasive disease among children ... Global literature review of Haemophilus influenzae type b and Streptococcus pneumoniae invasive disease among children less ...
2009)‎. Global literature review of Haemophilus influenzae type b and Streptococcus pneumoniae invasive disease among children ... Global literature review of Haemophilus influenzae type b and Streptococcus pneumoniae invasive disease among children less ...
Your search for HAEMOPHILUS INFLUENZAE TYPE B STRAIN 1482 CAPSULAR POLYSACCHARIDE TETANUS TOXOID CONJUGATE ANTIGEN did not ...
... J ... Objective: To characterize adverse events (AEs) after Haemophilus influenzae type b (Hib) vaccines reported to the US Vaccine ... Haemophilus Infections / prevention & control* * Haemophilus Vaccines / adverse effects* * Haemophilus influenzae type b / ...
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Read chapter 9 Haemophilus influenzae Type b Vaccines : Childhood immunization is one of the major public health measures of ... Haemophilus influenzae type b capsular polysaccharide conjugate vaccine in children after systemic Haemophilus influenzae type ... Haemophilus b conjugate vaccines for prevention of Haemophilus influenzae type b disease among infants and children two months ... Decreased Haemophilus colonization in children vaccinated with Haemophilus influenzae type b conjugate vaccine. Journal of ...
Haemophilus influenzae,/em, type b (Hib3) vaccine over time ... Haemophilus influenzae type b (Hib3) vaccination coverage. ... These data represent administrative and official Haemophilus influenzae type b (Hib) vaccination coverage (third dose) reported ... Introduction of Hib (Haemophilus influenzae type B) vaccine. Read more about Introduction of Hib (Haemophilus influenzae type ...
Vacinas Anti-Haemophilus/administração & dosagem Haemophilus influenzae tipo b/imunologia Meningite por Haemophilus/prevenção ... Impact of Haemophilus influenzae Type b conjugate vaccine in Mongolia: prospective population-based surveillance, 2002-2010.. ... This study assessed the impact of Haemophilus influenzae type b (Hib) conjugate vaccine on childhood bacterial meningitis in ... controle Cápsulas Bacterianas/imunologia Pré-Escolar Feminino Vacinas Anti-Haemophilus/imunologia Humanos Incidência Lactente ...
Number of new Haemophilus influenzae type b invasive disease cases, Categories: Morbidity, disability and hospital discharges ... Number of new Haemophilus influenzae type b invasive disease cases Visualizations Number of new Haemophilus influenzae type b ... Number of new Haemophilus influenzae type b invasive disease cases. Indicator code: E045316.T. Self explanatory. ICD-9: 3200. ... Number of new Haemophilus influenzae type b invasive disease cases (Line chart) ...
... haemophilus influenzae type b vaccine , haemophilus influenzae type b vaccine, pure polysaccharide , haemophilus influenza type ... The Haemophilus influenzae type B vaccine, also known as Hib vaccine, is a vaccine used to prevent Haemophilus influenzae type ... haemophilus influenzae type b conjugate vaccine , haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid ... tetanus toxoid polysaccharide-conjugated vaccine against haemophilus influenzae type b , type b haemophilus influenza conjugate ...
Haemophilus influenzae type b Conjugate Vaccine (Tetanus Toxoid Conjugate). ‡ Haemophilus influenzae type b Conjugate Vaccine ( ... Haemophilus influenzae type b Conjugate Vaccine (Tetanus Toxoid Conjugate). § Haemophilus influenzae type b Conjugate Vaccine ( ... influenzae type b disease and have been observed to have low immune responses to Haemophilus influenzae type b conjugate ... ActHIB® is a vaccine indicated for the prevention of invasive disease caused by Haemophilus influenzae (H. influenzae) type b. ...
Haemophilus influenzae type b (Hib) vaccination coverage among children 19-35 months by State, HHS Region, and the United ... 2017 Childhood Haemophilus influenzae type b (Hib) Vaccination Coverage Dashboard. ...
Haemophilus influenzae type b. *Hepatitis A and Hepatitis B. *Cervical & other cancers caused by human papillomavirus (HPV) ... Discuss whether an antibiotic or a different type of treatment is appropriate for your illness. ...
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Haemophilus influenzae type b (Hib) and Meningococcal group C (MenC) conjugate vaccines; which protect against otitis media; ... A study of Physico-Chemical Interactions between Haemophilus Influenzae Type b and Meningococcus group C Conjugate Vaccines ... A study of Physico-Chemical Interactions between Haemophilus Influenzae Type b and Meningo ... Full text: Available Index: AIM (Africa) Main subject: Vaccines / Haemophilus / Chemical Actions and Uses / Neisseria ...
Currently licensed Haemophilus influenzae type b conjugate vaccines have been shown to induce different temporal patterns of ... Immunogenicity of Haemophilus influenzae type b conjugate vaccines in infant rhesus monkeys. Pediatr Res 1991;29:10-3. *Granoff ... Interchangeability of conjugated Haemophilus influenzae type B (HIB) vaccines in infants. Pediatr Res {Abstract #493} 1993;33: ... Some vaccines contain highly defined antigens (e.g., the polysaccharide of Haemophilus influenzae type b or the surface antigen ...
Standing Orders for Administering Haemophilus influenzae type b Vaccine (Pediatric) Publication 5/15/2023 ...
Haemophilus influenzae type b. *Hepatitis A and Hepatitis B. *Cervical & other cancers caused by human papillomavirus (HPV) ...
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Pentacel® (containing Diphtheria, Tetanus Toxoids, Acellular Pertussis, Haemophilus influenzae type b, Polio Vaccine) ... Polio vaccine may be given as a stand-alone vaccine, or as part of a combination vaccine (a type of vaccine that combines more ...
  • We studied an immunogen consisting of oligosaccharides derived from Haemophilus influenzae type b capsular polysaccharide (PRP) coupled to CRM197, a nontoxic relative of diphtheria toxin. (nih.gov)
  • Safety and immunogenicity of Haemophilus influenzae type b-polysaccharide diphtheria toxoid conjugate vaccine in infants 9 to 15 months of age. (nih.gov)
  • Haemophilus influenzae is an aerobic gram-negative bacteria with a polysaccharide capsule with six different serotypes (a-f) of polysaccharide capsule. (freece.com)
  • 1985). Nearly 75 percent of cases of Hib disease occurred in children younger than 2 years of age, and the susceptibility of young children to infection with Hib correlated with their lack of antibody to the type b capsular polysaccharide, polyribosylribitol phosphate (PRP) (Ward and Cochi, 1988). (nationalacademies.org)
  • Thus, in consideration of the side effects of Hib conjugate vaccines, it is plausible that variations in the type or frequency of adverse effects may occur because of differences in the polysaccharide or protein components of the vaccines. (nationalacademies.org)
  • Invasive disease caused by the encapsulated bacteria Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae remains an important cause of morbidity and mortality worldwide, despite the introduction of successful conjugate polysaccharide vaccines that target disease-associated strains. (ox.ac.uk)
  • Hib vaccine can prevent Haemophilus influenzae type b (Hib) disease . (medlineplus.gov)
  • Hib vaccine may be given as a stand-alone vaccine, or as part of a combination vaccine (a type of vaccine that combines more than one vaccine together into one shot). (medlineplus.gov)
  • ActHIB is a vaccine indicated for the prevention of invasive disease caused by Haemophilus influenzae type b. (nih.gov)
  • Severe allergic reaction (e.g., anaphylaxis) after a previous dose of any Haemophilus influenzae type b or tetanus toxoid-containing vaccine or any component of ActHIB vaccine. (nih.gov)
  • ActHIB ® is a vaccine indicated for the prevention of invasive disease caused by Haemophilus influenzae (H. influenzae) type b. (nih.gov)
  • In Italy, the vaccine against Haemophilus influenzae type b (Hib) was licensed in 1995, but vaccination is voluntary. (cdc.gov)
  • elivaldogene autotemcel, haemophilus influenzae type b vaccine. (medscape.com)
  • To characterize adverse events (AEs) after Haemophilus influenzae type b (Hib) vaccines reported to the US Vaccine Adverse Event Reporting System (VAERS), a spontaneous reporting surveillance system. (nih.gov)
  • Impact of Haemophilus influenzae Type b conjugate vaccine in Mongolia: prospective population-based surveillance, 2002-2010. (bvsalud.org)
  • This study assessed the impact of Haemophilus influenzae type b ( Hib ) conjugate vaccine on childhood bacterial meningitis in Ulaanbaatar, Mongolia . (bvsalud.org)
  • The Haemophilus influenzae type B vaccine, also known as Hib vaccine, is a vaccine used to prevent Haemophilus influenzae type b (Hib) infection. (liu.edu)
  • Participants were enrolled between September 6, 2011, and October 9, 2011 (year 1), and from October 9, 2012, through October 21, 2012 (year 2), and were randomly assigned in a 1:1 allocation to receive 1 of the 2 vaccine types. (medscape.com)
  • How should I handle Haemophilus Influenzae type B (HiB) Vaccine safely? (sgh.com.sg)
  • How should I dispose of Haemophilus Influenzae type B (HiB) Vaccine safely? (sgh.com.sg)
  • The Hib vaccine contains extracts from the Haemophilus influenzae type b bacteria. (hse.ie)
  • The vaccine works by making the body's immune system respond if the vaccinated person comes in contact with Haemophilus influenzae type b bacteria, without causing disease. (hse.ie)
  • Between 95% and 100% of children become immune to Haemophilus Influenzae b (Hib) when they have completed the recommended vaccine schedule. (hse.ie)
  • Haemophilus influenzae type b bacteria (Hib) were the leading cause of meningitis in children younger than 5 years old until the Hib vaccine became available. (kidshealth.org)
  • The vaccine provides long-term protection from Haemophilus influenzae type b. (kidshealth.org)
  • H. influenzae type b was the leading cause of invasive bacterial disease among children in the United States prior to licensing of Haemophilus b conjugate vaccines in 1987. (freece.com)
  • Before effective vaccines were introduced, it was estimated that one in 200 children developed invasive H influenzae type b disease by the age of 5 years. (freece.com)
  • Prior to the introduction of Haemophilus influenzae type b (Hib) vaccines, Hib was the leading cause of bacterial meningitis in the United States among children younger than 4 years of age. (nationalacademies.org)
  • Haemophilus influenzae , a type of bacteria, can cause many different kinds of infections. (cdc.gov)
  • Doctors consider some H. influenzae infections "invasive. (cdc.gov)
  • H. influenzae can also be a common cause of ear infections in children and bronchitis in adults. (cdc.gov)
  • Haemophilus influenzae type b infections in day care attendees: implications for management. (nih.gov)
  • Title : Active Bacterial Core Surveillance (ABCs) Report Emerging Infections Program Network : Haemophilus influenzae, 2008 Corporate Authors(s) : National Center for Immunization and Respiratory Diseases (U.S.). Division of Bacterial Diseases. (cdc.gov)
  • A laboratory-based active surveillance of invasive H. influenzae disease was implemented in a sample of Italian regions in 1997 ( 4 ). (cdc.gov)
  • Hospital microbiologists were asked to send H. influenzae isolates to the national reference laboratory at Istituto Superiore di Sanità, where all strains were assayed by polymerase chain reaction (PCR) capsular genotyping. (cdc.gov)
  • Haemophilus influenzae type b [‎Hib]‎ can now be prevented by vaccination. (who.int)
  • These data represent administrative and official Haemophilus influenzae type b (Hib) vaccination coverage (third dose) reported annually through the WHO/UNICEF Joint Reporting Form on Immunization (JRF). (who.int)
  • Haemophilus influenzae type b (Hib) is bacteria that commonly causes bacterial meningitis and pneumonia and is the leading cause of other invasive diseases, such as septic arthritis (joint infection), epiglottitis (infection and swelling of the epiglottis) and cellulites (rapidly progressing skin infection which usually involves the face, head, or neck). (who.int)
  • Haemophilus influenzae b (Hib) is a bacteria that can cause serious infection in humans particularly in children, but also in individuals with weakened immune system or those who have no spleen or where the spleen is damaged by disease. (hse.ie)
  • Haemophilus influenzae b infection is caused by a contagious bacteria. (hse.ie)
  • For example, H. influenzae can invade the fluid around the spine and brain, causing meningitis, or bloodstream, causing bacteremia. (cdc.gov)
  • Since 1994, surveillance of H. influenzae meningitis has been conducted within the National Surveillance of Bacterial Meningitis ( 3 ). (cdc.gov)
  • Molecular typing methods for outbreak detection and surveillance of invasive disease caused by Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae, a review. (ox.ac.uk)
  • Doctors consider pneumonia an invasive infection when H. influenzae also infect the blood or fluid surrounding the lungs. (cdc.gov)
  • It was not until 1933 that it was established that influenza was caused by a virus and that H. influenzae was a cause of secondary infection. (freece.com)
  • We describe the first reported cases of invasive type e Haemophilus influenzae disease in Italy. (cdc.gov)
  • Active H. influenzae case finding was conducted by contacting, monthly, microbiologists from the regional laboratories of hospitals with infectious disease or pediatric wards. (cdc.gov)
  • A patient with invasive disease was defined as a patient with a compatible illness, accompanied by isolation of H. influenzae from a normally sterile site or detection of Hib antigen in cerebrospinal fluid. (cdc.gov)
  • We describe these five cases of invasive disease caused by H. influenzae type e (Hie). (cdc.gov)
  • Transmission of invasive Haemophilus influenzae type b disease in day care settings. (nih.gov)
  • It's entirely normal to ask yourself these types of questions, but there's something you should always remember: the more people are vaccinated, the less likely it will be for diseases to spread. (sbk.org)
  • Three types of immunobiologics are administered for passive immunization: a) pooled human IG or IGIV, b) specific immune globulin preparations, and c) antitoxins. (cdc.gov)
  • Secondary Haemophilus influenzae type b in day-care facilities. (nih.gov)
  • 165 were diagnosed by isolation of H. influenzae from a normally sterile site, and 54 were diagnosed by detection of Hib antigen in cerebrospinal fluid. (cdc.gov)
  • five were due to type e strain. (cdc.gov)
  • Discuss whether an antibiotic or a different type of treatment is appropriate for your illness. (nih.gov)
  • This need can be met with molecular and especially nucleotide sequence-based typing methods, which are fully developed in the case of N. meningitidis and which could be more widely deployed in clinical laboratories for S. pneumoniae and H. influenzae. (ox.ac.uk)
  • The following is a list of health product advisories, type I recalls as well as summaries of completed safety reviews published in October 2019 by Health Canada. (canada.ca)
  • Molecular analysis showed two distinct type e strains circulating in Italy, both containing a single copy of the capsulation locus. (cdc.gov)
  • On December 22, 1988, the Food and Drug Administration licensed an additional Haemophilus b Conjugate Vaccine for routine use in children greater than or equal to18 months of age. (cdc.gov)
  • The manufacturer is expected to begin distribution of the Haemophilus b Conjugate Vaccine (Diphtheria CRM197 Protein Conjugate) within a few weeks. (cdc.gov)
  • Recommendations of the Immunization Practices Advisory Committee for the use of Haemophilus b Conjugate Vaccine (Diphtheria Toxoid Conjugate) (1) are applicable to the new conjugate vaccine. (cdc.gov)
  • In Italy, the vaccine against Haemophilus influenzae type b (Hib) was licensed in 1995, but vaccination is voluntary. (medscape.com)
  • Hib vaccine can prevent Haemophilus influenzae type b (Hib) disease. (medlineplus.gov)
  • Hib vaccine may be given as a stand-alone vaccine, or as part of a combination vaccine Hib vaccine may be given as a stand-alone vaccine, or as part of a combination vaccine (a type of vaccine that combines more than one vaccine together into one shot). (medlineplus.gov)
  • Haemophilus influenzae type b (Hib) Vaccine Information Statement. (medlineplus.gov)
  • ActHIB is a vaccine indicated for the prevention of invasive disease caused by Haemophilus influenzae type b. (nih.gov)
  • Severe allergic reaction (e.g., anaphylaxis) after a previous dose of any Haemophilus influenzae type b or tetanus toxoid-containing vaccine or any component of ActHIB vaccine. (nih.gov)
  • ActHIB ® is a vaccine indicated for the prevention of invasive disease caused by Haemophilus influenzae (H. influenzae) type b. (nih.gov)
  • elivaldogene autotemcel, haemophilus influenzae type b vaccine. (medscape.com)
  • For more information, see the Centers for Disease Control and Prevention's (CDC) Haemophilus Influenzae type b (Hib) vaccine information statement . (msdmanuals.com)
  • The safety and immunogenicity of Haemophilus influenzae type b (Hib) capsular polysaccharide (CPS) alone, or covalently bound to tetanus toxoid in saline solution (Hib-TT) or adsorbed onto AI(OH)3 (Hib-TT ads), were evaluated after one injection into 18- to 23-month-old healthy children in Sweden. (nih.gov)
  • Here we define the capsule biosynthesis pathway of Haemophilus influenzae serotype b ( Hib ), a Gram-negative bacterium that causes severe infections in infants and children . (bvsalud.org)
  • [ 2 ] Since 1994, surveillance of H. influenzae meningitis has been conducted within the National Surveillance of Bacterial Meningitis. (medscape.com)
  • Haemophilus influenzae type b (Hib) is bacteria that commonly causes bacterial meningitis and pneumonia and is the leading cause of other invasive diseases, such as septic arthritis (joint infection), epiglottitis (infection and swelling of the epiglottis) and cellulites (rapidly progressing skin infection which usually involves the face, head, or neck). (who.int)
  • A patient with invasive disease was defined as a patient with a compatible illness, accompanied by isolation of H. influenzae from a normally sterile site or detection of Hib antigen in cerebrospinal fluid. (medscape.com)
  • We describe these five cases of invasive disease caused by H. influenzae type e (Hie). (medscape.com)
  • Healthy carriers of Haemophilus influenzae type b [‎Hib]‎ play an important role in the spread of invasive disease. (who.int)
  • [ 3 ] A laboratory-based active surveillance of invasive H. influenzae disease was implemented in a sample of Italian regions in 1997. (medscape.com)
  • Haemophilus influenzae type b (Hib) is one of the leading causes of invasive bacterial infection in young children worldwide. (nih.gov)
  • Type 508 Accommodation and the title of the report in the subject line of e-mail. (cdc.gov)
  • 165 were diagnosed by isolation of H. influenzae from a normally sterile site, and 54 were diagnosed by detection of Hib antigen in cerebrospinal fluid. (medscape.com)