A species of HAEMOPHILUS that appears to be the pathogen or causative agent of the sexually transmitted disease, CHANCROID.
Acute, localized autoinoculable infectious disease usually acquired through sexual contact. Caused by HAEMOPHILUS DUCREYI, it occurs endemically almost worldwide, especially in tropical and subtropical countries and more commonly in seaports and urban areas than in rural areas.
A genus of PASTEURELLACEAE that consists of several species occurring in animals and humans. Its organisms are described as gram-negative, facultatively anaerobic, coccobacillus or rod-shaped, and nonmotile.
A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.
Infections with bacteria of the genus HAEMOPHILUS.
A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.
Infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. HAEMOPHILUS INFLUENZAE TYPE B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults.
Proteins isolated from the outer membrane of Gram-negative bacteria.
A species of gram-negative bacteria (currently incertae sedis) causing multisystem disease in CATTLE.
Pathological processes involving the male reproductive tract (GENITALIA, MALE).
A type of H. influenzae isolated most frequently from biotype I. Prior to vaccine availability, it was a leading cause of childhood meningitis.
A species of gram-negative bacteria in the genus HAEMOPHILUS found, in the normal upper respiratory tract of SWINE.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Proteins found in any species of bacterium.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
An enzyme that forms CMP-acylneuraminic acids, which donate the N-acylneuraminic acid residues to the terminal sugar residue of a ganglioside or glycoprotein. EC 2.7.7.43.
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
The use of humans as investigational subjects.
A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Bacteriocins elaborated by mutant strains of Pseudomonas aeruginosa. They are protein or protein-lipopolysaccharide complexes lethal to other strains of the same or related species.
The functional hereditary units of BACTERIA.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The etiologic agent of TULAREMIA in man and other warm-blooded animals.
Inflammation of the lymph nodes.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
Hospital department which administers and provides pathology services.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)
A form of psychotherapy with emphasis on the interplay of organism and environment. Basic to this therapy is the development of awareness and maturity, as well as self-confidence.
The field of biology which deals with the process of the growth and differentiation of an organism.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
Information or data used to ensure the safe handling and disposal of substances in the workplace. Such information includes physical properties (i.e. melting, boiling, flashing points), as well as data on toxicity, health effects, reactivity, storage, disposal, first-aid, protective equipment, and spill-handling procedures.
Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
A republic in eastern Africa, south of UGANDA, east of DEMOCRATIC REPUBLIC OF THE CONGO, west of TANZANIA. Its capital is Kigali. It was formerly part of the Belgian trust territory of Ruanda-Urund.
The geographical area of Africa comprising ANGOLA; BOTSWANA; LESOTHO; MALAWI; MOZAMBIQUE; NAMIBIA; SOUTH AFRICA; SWAZILAND; ZAMBIA; and ZIMBABWE.
Antibodies produced by a single clone of cells.

Experimental infection of human volunteers with Haemophilus ducreyi does not confer protection against subsequent challenge. (1/298)

Two groups of human volunteers were inoculated with 2 doses of live Haemophilus ducreyi 35000HP. The reinfection group consisted of 7 subjects who previously had participated in experimental infection with 35000HP to the pustular stage of disease. The control group consisted of 7 naive subjects. Papules developed at 92.8% (95% confidence interval [CI], 66.1%-99.8%) of sites inoculated with live bacteria, in the reinfection group, and at 85.7% (95% CI, 57.2%-98. 2%) of sites in the control group. Sixty-nine percent (95% CI, 36. 8%-90.9%) of papules evolved into pustules in the reinfection group, compared with 41% (95% CI, 15.2%-72.3%) in the control group. The recovery rates of H. ducreyi from surface cultures and the histopathology of biopsies obtained from both groups were similar. Thus, experimental infection to the pustular stage of disease does not provide protective immunity against subsequent challenge.  (+info)

Binding of Haemophilus ducreyi to extracellular matrix proteins. (2/298)

We developed an enzyme-linked immunosorbent assay-based assay to assess Haemophilus ducreyi binding to extracellular matrix (ECM) proteins. H. ducreyi 35000HP bound to fibronectin, laminin, and type I and III collagen but not to type IV, V, or VI collagen or elastin. Isogenic strains with mutations in ftpA or losB bound as well as the parent, suggesting that neither pili nor full-length lipooligosaccharide is required for H. ducreyi to bind to ECM proteins.  (+info)

Molecular characterization of Haemophilus ducreyi strains from Jackson, Mississippi, and New Orleans, Louisiana. (3/298)

Chancroid, a sexually transmitted disease caused by Haemophilus ducreyi, is one of the most common genital ulcer diseases in developing countries. In the United States, while less common, the disease has been associated with outbreaks in inner cities, particularly among persons who engage in sex for drugs or money. Two outbreaks of chancroid were recently studied in the United States, one in New Orleans (from 1990 to 1992) and one in Jackson, Mississippi (from 1994 to 1995). By use of ribotyping, plasmid content, and antibiotic susceptibility, the chancroid cases in New Orleans were found to be due to a limited number of strains, consistent with a limited introduction of H. ducreyi into this community. The H. ducreyi isolates from New Orleans and Jackson had different ribotype patterns, suggesting that the two outbreaks were probably not linked.  (+info)

Prevalence of, antibody response to, and immunity induced by Haemophilus ducreyi hemolysin. (4/298)

Haemophilus ducreyi, the etiologic agent of chancroid, a genital ulcer disease, produces a cell-associated hemolysin whose role in virulence is not well defined. Hemolysin is encoded by two genes, hhdA and hhdB, which, based on their homology to Serratia marcescens shlA and shlB genes, are believed to encode the hemolysin structural protein and a protein required for secretion and modification of this protein, respectively. In this study, we determined the prevalence and expression of the hemolysin genes in 90 H. ducreyi isolates obtained from diverse geographic locations from 1952 to 1996 and found that all strains contained DNA homologous to the hhdB and hhdA genes. In addition, all strains expressed a hemolytic activity. We also determined that hemolysin is expressed in vivo and is immunogenic, as indicated by the induction of antibodies to hemolysin in both the primate and rabbit disease models as well as in human patients with naturally acquired chancroid. Wild-type strain 35000 and isogenic hemolysin-negative mutants showed no difference in lesion development in the temperature-dependent rabbit model. However, immunization of rabbits with the purified hemolysin protein reduced the recovery of wild-type H. ducreyi, but not hemolysin-negative mutants, from lesions. Our study indicates that hemolysin is a possible candidate for vaccine development due to its immunogenicity, expression in vitro and in vivo by most, if not all, strains, and the effect of immunization on reducing the recovery of viable H. ducreyi in experimental disease in rabbits.  (+info)

Target cell range of Haemophilus ducreyi hemolysin and its involvement in invasion of human epithelial cells. (5/298)

Haemophilus ducreyi, the causative agent of chancroid, produces a hemolysin, whose role in virulence is not well defined. To assess the possible role of hemolysin in pathogenesis, we evaluated its target cell range by using wild-type H. ducreyi 35000, nonhemolytic mutants with the hemolysin structural gene deleted, and isogenic strains expressing different amounts of hemolytic activity. The cytotoxicity of the various cell types was assessed by quantitating the release of lactate dehydrogenase into culture supernatants as a measure of cell lysis. In these experiments, human foreskin fibroblasts, human foreskin epithelial cells, and, to a lesser extent, HEp-2 cells were lysed by H. ducreyi hemolysin. Hemolysin also lysed human blood mononuclear cells and immune system cell lines including U937 macrophage-like cells, T lymphocytes, and B lymphocytes. In contrast, human polymorphonuclear leukocytes were not sensitive to hemolysin under the conditions tested. We also analyzed the effect of hemolysin on invasion of human epithelial cells and found that H. ducreyi strains expressing cloned hemolysin genes showed a 10-fold increase in invasion compared to the control strain. These data support the hypothesis that the H. ducreyi hemolysin is important in the pathogenesis of chancroid and may contribute to ulcer formation, invasion of epithelial cells, and evasion of the immune response.  (+info)

Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin. (6/298)

Haemophilus ducreyi expresses a soluble cytolethal distending toxin (CDT) that kills HeLa, HEp-2, and other human epithelial cells in vitro. H. ducreyi CDT activity is encoded by a three-gene cluster (cdtABC), and antibody to the cdtC gene product can neutralize CDT activity in vitro (L. D. Cope, S. R. Lumbley, J. L. Latimer, J. Klesney-Tait, M. K. Stevens, L. S. Johnson, M. Purven, R. S. Munson, Jr., T. Lagergard, J. D. Radolf, and E. J. Hansen, Proc. Natl. Acad. Sci. USA 94:4056-4061, 1997). Culture supernatant fluid from a recombinant Escherichia coli strain containing the H. ducreyi cdtABC gene cluster readily killed both HeLa cells and HaCaT keratinocytes and had a modest inhibitory effect on the growth of human foreskin fibroblasts. Insertional inactivation of the cdtC gene in this recombinant E. coli strain eliminated the ability of this strain to kill HeLa cells and HaCaT keratinocytes. This mutated H. ducreyi cdtABC gene cluster was used to construct an isogenic H. ducreyi cdtC mutant. Monoclonal antibodies against the H. ducreyi CdtA, CdtB, and CdtC proteins were used to characterize protein expression by this cdtC mutant. Culture supernatant fluid from this H. ducreyi cdtC mutant did not detectably affect any of the human cells used in this study. The presence of the wild-type H. ducreyi cdtC gene in trans in this H. ducreyi mutant restored its ability to express a CDT that killed both HeLa cells and HaCaT keratinocytes. The isogenic H. ducreyi cdtC mutant was shown to be as virulent as its wild-type parent strain in the temperature-dependent rabbit model for experimental chancroid. Lack of expression of the H. ducreyi CdtC protein also did not affect the ability of this H. ducreyi mutant to survive in the skin of rabbits.  (+info)

Genital ulcers: etiology, clinical diagnosis, and associated human immunodeficiency virus infection in Kingston, Jamaica. (7/298)

Individuals presenting consecutively with genital ulcers in Kingston, Jamaica, underwent serological testing for human immunodeficiency virus (HIV) infection, chlamydial infection, and syphilis. Ulcer material was analyzed by multiplex polymerase chain reaction (M-PCR) analysis. DNA from herpes simplex virus (HSV), Haemophilus ducreyi, and Treponema pallidum was detected in 158 (52.0%), 72 (23.7%), and 31 (10.2%) of 304 ulcer specimens. Of the 304 subjects, 67 (22%) were HIV-seropositive and 64 (21%) were T. pallidum-seroreactive. Granuloma inguinale was clinically diagnosed in nine (13.4%) of 67 ulcers negative by M-PCR analysis and in 12 (5.1%) of 237 ulcers positive by M-PCR analysis (P = .03). Lymphogranuloma venereum was clinically diagnosed in eight patients. Compared with M-PCR analysis, the sensitivity and specificity of a clinical diagnosis of syphilis, herpes, and chancroid were 67.7%, 53.8%, and 75% and 91.2%, 83.6%, and 75.4%, respectively. Reactive syphilis serology was 74% sensitive and 85% specific compared with M-PCR analysis. Reported contact with a prostitute in the preceding 3 months was associated with chancroid (P = .009), reactive syphilis serology (P = .011), and HIV infection (P = .007). The relatively poor accuracy of clinical and locally available laboratory diagnoses pleads for syndromic management of genital ulcers in Jamaica. Prevention efforts should be intensified.  (+info)

Immune cells are required for cutaneous ulceration in a swine model of chancroid. (8/298)

Cutaneous lesions of the human sexually transmitted genital ulcer disease chancroid are characterized by the presence of intraepidermal pustules, keratinocyte cytopathology, and epidermal and dermal erosion. These lesions are replete with neutrophils, macrophages, and CD4(+) T cells and contain very low numbers of cells of Haemophilus ducreyi, the bacterial agent of chancroid. We examined lesion formation by H. ducreyi in a pig model by using cyclophosphamide (CPA)-induced immune cell deficiency to distinguish between host and bacterial contributions to chancroid ulcer formation. Histologic presentation of H. ducreyi-induced lesions in CPA-treated pigs differed from ulcers that developed in immune-competent animals in that pustules did not form and surface epithelia remained intact. However, these lesions had significant suprabasal keratinocyte cytotoxicity. These results demonstrate that the host immune response was required for chancroid ulceration, while bacterial products were at least partially responsible for the keratinocyte cytopathology associated with chancroid lesions in the pig. The low numbers of H. ducreyi present in lesions in humans and immune-competent pigs have prevented localization of these organisms within skin. However, H. ducreyi organisms were readily visualized in lesion biopsies from infected CPA-treated pigs by immunoelectron microscopy. These bacteria were extracellular and associated with necrotic host cells in the epidermis and dermis. The relative abundance of H. ducreyi in inoculated CPA-treated pig skin suggests control of bacterial replication by host immune cells during natural human infection.  (+info)

Haemophilus ducreyi previously has been shown to inhibit the phagocytosis of both secondary targets and itself by certain cells in vitro. Wild-type H. ducreyi strain 35000HP contains two genes, lspA1 and lspA2, whose encoded protein products are predicted to be 456 and 543 kDa, respectively. An isogenic mutant of H. ducreyi 35000HP with inactivated lspA1 and lspA2 genes has been shown to exhibit substantially decreased virulence in the temperature-dependent rabbit model for chancroid. This lspA1 lspA2 mutant was tested for its ability to inhibit phagocytosis of immunoglobulin G-opsonized particles by differentiated HL-60 and U-937 cells and by J774A.1 cells. The wild-type strain H. ducreyi 35000HP readily inhibited phagocytosis, whereas the lspA1 lspA2 mutant was unable to inhibit phagocytosis. Similarly, the wild-type strain was resistant to phagocytosis, whereas the lspA1 lspA2 mutant was readily engulfed by phagocytes. This inhibitory effect of wild-type H. ducreyi on phagocytic activity was ...
TY - JOUR. T1 - Experimental infection of human volunteers with Haemophilus ducreyi. T2 - Fifteen years of clinical data and experience. AU - Janowicz, Diane M.. AU - Ofner, Susan. AU - Katz, Barry P.. AU - Spinola, Stanley M.. PY - 2009/6/1. Y1 - 2009/6/1. N2 - Haemophilus ducreyi causes chancroid, which facilitates transmission of human immunodeficiency virus type 1. To better understand the biology of H. ducreyi, we developed a human inoculation model. In the present article, we describe clinical outcomes for 267 volunteers who were infected with H. ducreyi. There was a relationship between papule formation and estimated delivered dose. The outcome (either pustule formation or resolution) of infected sites for a given subject was not independent; the most important determinants of pustule formation were sex and host effects. When 41 subjects were infected a second time, their outcomes segregated toward their initial outcome, confirming the host effect. Subjects with pustules developed local ...
TY - JOUR. T1 - Haemophilus ducreyi targets Src family protein tyrosine kinases to inhibit phagocytic signaling. AU - Mock, Jason R.. AU - Vakevainen, Merja. AU - Deng, Kaiping. AU - Latimer, Jo L.. AU - Young, Jennifer A.. AU - Van Oers, Nicolai S C. AU - Greenberg, Steven. AU - Hansen, Eric J.. PY - 2005/12. Y1 - 2005/12. N2 - Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, has been shown to inhibit phagocytosis of both itself and secondary targets in vitro. Immunodepletion of LspA proteins from H. ducreyi culture supernatant fluid abolished this inhibitory effect, indicating that the LspA proteins are necessary for the inhibition of phagocytosis by H. ducreyi. Fluorescence microscopy revealed that macrophages incubated with wild-type H. ducreyi, but not with a lspA1 lspA2 mutant, were unable to complete development of the phagocytic cup around immunoglobulin G-opsonized targets. Examination of the phosphotyrosine protein profiles of these two sets of ...
TY - JOUR. T1 - Activation of CpxRA in Haemophilus ducreyi primarily inhibits the expression of Its targets, including major virulence determinants. AU - Gangaiah, Dharanesh. AU - Zhang, Xinjun. AU - Fortney, Kate R.. AU - Baker, Beth. AU - Liu, Yunlong. AU - Munson, Robert S.. AU - Spinola, Stanley. PY - 2013/8. Y1 - 2013/8. N2 - Haemophilus ducreyi causes chancroid, a genital ulcer disease that facilitates the transmission of human immunodeficiency virus type 1. In humans, H. ducreyi is surrounded by phagocytes and must adapt to a hostile environment to survive. To sense and respond to environmental cues, bacteria frequently use two-component signal transduction (2CST) systems. The only obvious 2CST system in H. ducreyi is CpxRA; CpxR is a response regulator, and CpxA is a sensor kinase. Previous studies by Hansen and coworkers showed that CpxR directly represses the expression of dsrA, the lspB-lspA2 operon, and the flp operon, which are required for virulence in humans. They further showed ...
1. Ballard RC, Duncan MO, Fehler HG, Dangor Y, Exposto FL, Latif AS. Treating chancroid: summary of studies in southern Africa. Genitourin Med 1989;65:54-7. [PubMed]. 2. Bauer ME, Townsend CA, Ronald AR, Spinola SM. Localization of Haemophilus ducreyi in naturally acquired chancroidal ulcers. Microbes Infect 2006;8(9-10):2465-2468. [PubMed]. 3. Behets FM, Liomba G, Lule G, Dallabetta G, Hoffman IF, Hamilton HA, Moeng S, Cohen MS. Sexually transmitted diseases and human immunodeficiency virus control in Malawi: a field study of genital ulcer disease. J Infect Dis 1995;171:451-5.[PubMed]. 4. Bogaerts J, Kestens L, Martinez Tello W, Akingeneye J, Mukantabana V, Verhaegen J, Van Dyck E, Piot P. Failure of treatment for chancroid in Rwanda is not related to human immunodeficiency virus infection: in vitro resistance to Haemophilus ducreyi to trimethoprim-sulphamethoxazole. Clin Infect Dis 1995;20:924-30. [PubMed]. 5 Centers for Disease Control and Prevention. Sexually transmitted disease ...
Haemophilus ducreyi is a fastidious gram-negative coccobacillus bacteria, which causes the sexually transmitted disease chancroid, a major cause of genital ulceration in developing countries characterized by painful sores on the genitalia. Chancroid starts as an erythematous papular lesion that breaks down into a painful bleeding ulcer with a necrotic base and ragged edge. H. ducreyi can be cultured on chocolate agar. It is best treated with a macrolide like azithromycin and a third-generation cephalosporin like ceftriaxone. H. ducreyi gram stain appears as school of fish. H. ducreyi is an opportunistic microorganism that infects its host by way of breaks in the skin or epidermis. Inflammation then takes place as the area of infection is inundated with lymphocytes, macrophages, and granulocytes. This pyrogenic inflammation causes regional lymphadenitis in the sexually transmitted bacillus chancroid. Although antigen detection, serology, and genetic amplification methods are sometimes used to ...
TY - JOUR. T1 - Identification of tandem genes involved in lipooligosaccharide expression by Haemophilus ducreyi. AU - Stevens, Marla K.. AU - Klesney-Tait, Julia. AU - Lumbley, Sheryl. AU - Walters, K. A.. AU - Joffe, A. Mark. AU - Radolf, Justin D.. AU - Hansen, Eric J.. PY - 1997/2/1. Y1 - 1997/2/1. N2 - A transposon insertion mutant of Haemophilus ducreyi 35000 possessing a truncated lipooligosaccharide (LOS) failed to hind the LOS-specific monoclonal antibody 3E6 (M. K. Stevens, L. D. Cope, J. D. Radolf and E. J. Hansen, Infect. Immun. 63:2976-2982, 1995). This transposon was found to have inserted into the first of two tandem genes and also caused a deletion of chromosomal DNA upstream of this gene. These two genes, designated lbgA and lbgB, encoded predicted proteins with molecular masses of 25,788 and 40,236 Da which showed homology with proteins which function in lipopolysaccharide biosynthetic in other gram-negative bacteria. The tandem arrangement of the lbgA and lbgB genes was found ...
A monoclonal antibody raised against Haemophilus ducreyi was tested for its sensitivity and specificity as an immunofluorescence (IF) reagent using simulated vaginal smears containing H. ducreyi, smears taken from skin lesions of mice infected with H. ducreyi and patients from South Africa, Thailand and Malaysia with clinically diagnosed chancroid. The IF test was more sensitive than culture or Gram staining in the simulated smears, theoretically detecting less than 4 organisms/sample. It detected H. ducreyi in 95% of the animal lesions compared with 14% detected by culture. Immunofluorescence testing identified over 90% of culture-positive cases of chancroid but also detected organisms in some culture-negative cases where clinical evidence for the diagnosis was strong. These results suggest that this antibody may provide a simple, rapid and sensitive means of detecting H. ducreyi in cases of chancroid.
TY - JOUR. T1 - Standardization of an enzyme immunoassay for human antibody to Haemophilus ducreyi. AU - Desjardins, M. AU - Thompson, CE. AU - Filion, LG. AU - Ndinya-Achola, JO. AU - Plummer, FA. AU - Ronald, AR. AU - Piot, P. AU - Cameron, DW. PY - 1992. Y1 - 1992. KW - B780-tropical-medicine. KW - Bacteriology. KW - Haemophilus ducreyi. KW - Antibody detection. KW - Immunoenzyme techniques. KW - Immunoglobulin G. KW - Immunoglobulin M. KW - Screening. KW - STD. KW - Sexually transmitted diseases. KW - Laboratory techniques and procedures. M3 - A1: Web of Science-article. VL - 30. SP - 2019. EP - 2024. JO - Journal of Clinical Microbiology. JF - Journal of Clinical Microbiology. SN - 0095-1137. ER - ...
Haemophilus ducreyi ATCC ® 700724D-5™ Designation: Genomic DNA from Haemophilus ducreyi 35000HP TypeStrain=False Application:
† Ulcerative genital disease in the United States is commonly due to herpes simplex or syphilis. Until recently, chancroid, an infection caused by the gram-nega
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To investigate if temperature affects the interaction of Haemophilus ducreyi with human epithelial cells, nine strains were used to evaluate the adhesion kinetics of the organism at 33°C and 37°C. The effect of the free toxin on the epithelial cells at those temperatures was also assessed. The cyto-adherence kinetics of H. ducreyi to the epithelial cells was significantly greater at 33°C (10 times more) than at 37°C in all seven clinical isolates tested. There was a significant difference in cell-associated H. ducreyi at 33°C as compared with 37°C. Control strains showed similar adhesion properties at both temperatures. However, the virulent strain CIP542 adhered in larger amounts than the avirulent strain A77. Electron microscopy revealed that there was more tissue necrosis at the lower than the higher temperature. The effect of the free toxin was the same at each temperature. However, strain A77 had significantly lower toxicity than strain CIP542 and the clinical isolates. These results suggest
Pyocin lysis has previously been used as a strategy to identify LOS mutants of H. ducreyi and N. gonorrhoeae(8, 14). Although the actual mechanism of lysis is poorly understood, a recent report by Lee et al. suggests that these particles contain nucleic acid (27). In this study, we used pyocin to select for LOS mutants of H. ducreyi strain 35000. One such mutant, HD35000R, produced a LOS molecule that lacked the MAb 3F11 epitope and migrated with an increased mobility on SDS-PAGE. Complementation of this mutant with a plasmid library containingH. ducreyi 35000 chromosomal DNA resulted in the identification of a clone expressing wild-type LOS. Western blot analysis confirmed that this transformant, HD35000R(pLS88.8), expressed the LOS epitope reactive with MAb 3F11. The sequence analysis of the complementing plasmid revealed a 3.2-kb DNA insert containing four complete ORFs. The putative protein product of ORF1 shared similarity (37%) with the E. coli WaaQ, the heptosyltransferase responsible for ...
Summary Routine procedures used to isolate Haemophilus ducreyi in a busy laboratory are reported. Identification was based on colony morphology and nutritional and biochemical properties of 120 fresh isolates of H. ducreyi. These isolates grew very well on Gonococcal Agar and Mueller-Hinton Agar incubated at 34°C in candle extinction jars containing moistened filter paper. Colonies varied in size, giving a polymorphic appearance. They were smooth, dome-shaped, and buff-yellow to grey in colour, and measured 2 mm in diameter. They could be pushed intact across the agar surface. By microscopic examination of gram-stained smears the isolates were gram-negative coccobacilli arranged in short chains, clumps or whorls and occasionally in typical
Sigma-Aldrich offers abstracts and full-text articles by [Dana A Dodd, Randall G Worth, Michael K Rosen, Sergio Grinstein, Nicolai S C van Oers, Eric J Hansen].
SOP: Cloning of PCR Product. Add 1 ml room-temperature LB broth (without ampicillin) to the tube. A-9518) agar plate pre-spread with 20 µl X-Gal (50 mg/ml.haemophilus ducreyi. FAQ. Haemophilus ducreyi; Haemophilus;. and then to plate it on blood agar and chocolate agar.thoroughly and pour plates. YEPD (YPD) PLATES: Agar 20 g. Peptone 10 g. Yeast Extract 900 ml distilled water: 5 ml of 1 M HCl (do not mouth pipette) 20 g. Agar Autoclave.1 Genomic tools and cDNA derived markers for butterflies. the library was plated out on LB agar plates with Xgal blue/white 116 screening and 0.1% ampicillin,.. ...
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|p|Azithral is used for infections caused by susceptible organisms in-|/p||p|Upper respiratory tract infections including sinusitis, pharyngitis and tonsillitis|/p||p|Lower respiratory tract infections including bronchitis, acute bacterial exacerbations of chronic obstructive pulmonary|/p||p|disease (COPD)|/p||p|Otitis media|/p||p|Skin and soft tissue infections including cellulitis, pyoderma, erysipelas, wound infections|/p||p|Diarrhea, Shigellosis|/p||p|Sexually transmitted diseases, especially in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis|/p||p|Genital ulcer disease in men due to Haemophilus ducreyi (chancroid)|/p||p|Mild or moderate typhoid due to multiple-antibacterial resistant organisms|/p||p|Prophylaxis against a-hemolytic (viridans group) streptococcal bacterial endocarditis|/p||p|Other infections including odontogenic infections, bartonella infections, toxoplasmosis, babesiosis|/p|
Abdullah, M.T., Nepliounev, I., Alfonina, G., Ram, S., Rice, P., Elkins, C. (2005). Killing of dsrA mutants of haemophilus ducreyi by normal human serum occurs via the classical complement pathway and is initiated by immunoglobulin m binding. Infection and Immunity. 73: 3431-3439 ...
bacteria HupA protein: HupA - Hemoglobin Utilization Protein A; a hemoglobin-binding protein; MW 108 kDa; GenBank U34048 (Haemophilus ducreyi)
Week 1 started fairly slowly, which gave me a chance to read up on several papers about research already carried on PcaK and the AAHS family. I began by culturing E. Coli which had been transformed with a plasmid containing the PcaK gene of the extremophile Haemophilus ducreyi, and then induced these via addition of arabinose (to turn on T7 RNA polymerase expression) and IPTG (to turn on protein expression). Unfortunately, the cells started to die on induction of protein expression - a possible explanation for this being that the protein is toxic to E. coli growth. This may lead to a low final concentration once purified, as its possible that the cells that survived were those that were not expressing the protein! I proceeded to harvest the cells via centrifugation and then resuspend the pellets in PBS buffer and TCEP (reduces disulphide bonds). Next I got to use a cell disrupter to lyse the cells and, after an inital centrifugation to remove debris and unlysed cells, I pelleted the membranes ...
Hemophilus Ducreyi Symptom Checker: Possible causes include Sexually Transmitted Disease. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Chancroid is a sexually transmitted disease (STD) caused by a bacterium called Haemophilus Ducreyi. The disease is completely curable but causes ulcers, generally in the genital area.. Chancroid is mainly passed from person to person with genital contact, but can also be spread via oral intercourse, anal intercourse, and through areas of broken skin. In addition, the infection can be transmitted non-sexually when fluid from Chancroid ulcers are transferred from an infected person to another individual.. The disease is more common in men that in women, and as a result, Chancroid sores (usually referred to as soft chancres) often develop in the groin area with painful and swollen lymph glands.. History of Chancroid. It is understood that Chancroid had its origins from Africa, and it is quite a common disease in the Caribbean and Southwest Asia. However, the disease is becoming more and more prevalent in the United States.. Symptoms of Chancroid. If you develop symptoms of Chancroid, they will most ...
Chancroid is a sexually transmitted disease caused by Haemophilus ducreyi infection leading to genital ulcers and painful lymphadenopathy, from the online textbook of urology by D. Manski
U08MM1072. Gonorrhoea, Chlamydia, Genital herpes are common sexually transmitted diseases that people are aware of, but are you among many to be coming across Chancroid for the first time?. Chancroid is a bacterial infection that can be spread through sexual contact. this bacteria is called Haemophilus Ducreyi and it is most common in Africa and southwest Asia. Chancroid can occur in both men and women and in 1 day to 2 weeks after becoming infected, a small bump appears on the genitals which becomes an ulcer within a day after it appears. For men, only 1 ulcer may appear in the foreskin, shaft of the penis, head of the penis or the scrotum. For women, 4 or more ulcers may appear in the outer lips of the vagina (Labia Majora), inner vagina lips and inner thighs.. Chancroid can cause urethral fistulas (a scar that develops in the urethra) and scars on the foreskin of the penis. People with Chancroid should be checked for other STDs like Syphillis, HIV or Genital Herpes. For people with HIV, ...
Dear Reader,. It seems youre ready to sharpen your chancroid (starts with a sh sound) knowledge! On to it then: Chancroid is a bacterial infection transmitted through contact with sores on an infected individuals skin. The bacteria, Haemophilus ducreyi, can lead to painful, open sores and swollen lymph nodes, usually in the groin area. Its relatively rare in the United States (including in infants and children), and appears to be more prevalent in some regions of Africa and the Caribbean. Its also more common in those assigned male at birth that those assigned female at birth (but those assigned female can be asymptomatic carriers). A proper diagnosis is key to appropriate treatment, as symptoms of chancroid can be confused with primary syphilis. But, fear not, because its treatable; antibiotics are typically used to speed up the healing process, but the sores may also clear up on their own. If left untreated though, chancroid can lead to skin damage. Keep reading for even more detailed ...
Tetracyclines and sulfonamides are no longer effective for the treatment of chancroid in many parts of the world. Rifampin and trimethoprim both possess in vitro activity against Haemophilus ducreyi, the causative agent of chancroid. In a randomized, controlled study, 22 patients with H. ducreyi-positive genital ulcers received 600 mg of rifampin once daily for three days, and 32 patients received 600 mg of rifampin plus 160 mg of trimethoprim once daily for three days. Both regimens rapidly eradicated H. ducreyi from ulcers, with subsequent healing of ulcers and buboes. Two relapses of ulcers and one therapeutic failure were observed in the rifampin-trimethoprim group, whereas no relapses or failures were noted in the rifampin group. In addition, all of 16 H. ducreyi-negative ulcers responded rapidly to treatment with either regimen. In an uncontrolled, open study, 22 H. ducreyi-positive ulcers were treated with a single dose of rifampin (600 mg) plus trimethoprim (160 mg). Ulcers and buboes ...
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Chancroid is a type of sexually transmitted disease. Chancroid is a bacterial (Hemophilus ducreyi) infection with an incubation period of 3-14 days. The incubation period is the time between exposure to the infection (sexual event) and the development of symptoms associated with this infection. Common presentation includes one or more painful lumps, or swellings, to the groin area (usually on both sides). Females may also have a vaginal discharge and lower pelvic pain that is more severe during intercourse. Males and females may have multiple ragged ulcers to the penis or vulva.. Treatment is with orally administered antibiotics. Abscess formation (pockets of pus under the skin) is not uncommon, and incision and drainage of the abscess (by a physician) will be necessary in these cases. Regular application of warm wet compresses to the swollen inguinal area, in addition to treatment with antibiotics, can help eradicate this infection. Sexual intercourse should be avoided until the infection as ...
Chancroid is a sexually transmitted infection caused by the bacteria Haemophilus ducreyi. It causes painful open sores in the genital area and may cause swollen lymph nodes in the groin. It is rare in North America and Europe and is sometimes difficult to diagnose. Find out about treatment and prevention.
en] Anti-Bacterial Agents/therapeutic use ; Chancre/complications/pathology ; Chancroid/complications/pathology ; Erythromycin/therapeutic use ; Haemophilus Infections/complications/diagnosis/drug therapy/pathology ; Haemophilus ducreyi/isolation & purification ; Humans ; Male ; Syphilis/complications/diagnosis/drug therapy/pathology ; Treatment Outcome ; Treponema pallidum/isolation & purification ; Young ...
Treatment for Chancroid. Find Doctors Near You, Book Appointment, Consult Online, View Doctor Fees, Address, Phone Numbers and Reviews. Doctors for Chancroid | Lybrate
The cytolethal distending toxins (CDTs) are a family of exotoxins produced by a wide range of Gram-negative bacteria. They are known for causing genotoxic stress to the cell, resulting in growth arrest and eventually apoptotic cell death. Nevertheless, there is evidence that CDTs can also perturb the innate immune responses, by regulating inflammatory cytokine production and molecular mediators of bone remodeling in various cell types. These cellular and molecular events may in turn have an effect in enhancing local inflammation in diseases where CDT-producing bacteria are involved, such as Aggregatibacter actinomycetemcomitans, Haemophilus ducreyi, Campylobacter jejuni and Helicobacter hepaticus. One special example is the induction of pathological bone destruction in periodontitis. The opportunistic oral pathogen Aggregatibatcer actinoycemetemcomitans, which is involved in the aggressive form of the disease, can regulate the molecular mechanisms of bone remodeling in a manner that favors bone
2015 Strategies in the Chancroid Diagnostics Testing Market The report presents a detailed analysis of the Chancroid diagnostics market in the US, Europe (France, Germany, - Market research report and industry analysis - 9079292
[220 Pages Report] Check for Discount on Chancroid: US, Europe, Japan--Market Analysis, Competitive Intelligence, Technology Trends, Opportunities for Suppliers report by Venture Planning Group. The report presents a detailed analysis of the Chancroid diagnostics...
Public Health Labs. In addition to test volume and sales projections, the report presents sales and market share estimates for major suppliers of Chancroid tests.. Also, the report examines the market applications of DNA Probes, Monoclonal Antibodies, Immunoassays, IT and other technologies; reviews features and operating characteristics of automated analyzers; profiles leading suppliers and recent market entrants developing innovative technologies and products; and identifies emerging business expansion opportunities, alternative market penetration strategies, market entry barriers and risks, and strategic planning issues and concerns.. Contains 220 pages and 8 tables. ...
Chancroid is a bacterial infection that causes open sores on the genitals. We explain how its spread, the symptoms to expect, and how its treated.
Chancroid is a type of sexually transmitted bacterial infection causing painful sores on the genitals. It is a rare type of infection affecting men and women
Compare risks and benefits of common medications used for Chancroid. Find the most popular drugs, view ratings, user reviews, and more...
OK horn dogs (yea this includes myself) heres the facts. STD Fact Sheets Information on 11 common sexually transmitted diseases CHANCROID WHAT IT IS: A...
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Learn about the causes, symptoms, diagnosis & treatment of Sexually Transmitted Diseases (STDs) from the Home Version of the Merck Manuals.
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Acne pustules and blackheads occur when oil blocks a hair follicle and forms a plug. Blackheads are open at the surface of the skin, causing the dirt and oil in the pore to oxidize and turn dark. Pustules are closed, hidden beneath the skin. They appear a
NAA, serology, microscopy and culture, cytology, (Genital swab).. See also Human papillomavirus infection, Vaginal discharge, Trichomonas vaginalis infection, Toxic shock syndrome, Candidiasis, Syphilis, Pelvic inflammatory disease, Orchitis, Mycoplasma infection, Lymphogranuloma venereum, Human papillomavirus infection, Herpes simplex virus infection, HIV infection, Chancroid (Haemophilus ducreyi infection), Granuloma inguinale (donovanosis), Gonococcal infection, Gonorrhoea, Bartholins abcess.. ...
The goal was to estimate the cofactor effect of genital ulcer disease (GUD) on the risk of HIV transmission during a single heterosexual exposure. The relation between the risk ratio observed in an epidemiological study and the per-exposure cofactor effect was investigated. Given simple assumptions, …
Ceftriaxone in a dose of 250 mg given intramuscularly is currently recommended for the treatment of chancroid. Among 133 men in Nairobi, Kenya, with culture-proven chancroid, who were treated with ceftriaxone, treatment ...
Australian STI Management Guidelines for Use in Primary Care are nationally endorsed guidelines on the testing, diagnosis, management and treatment of STIs.
The physician poked a pustule on the shin with a needle and there was a small amount of purulent drainage. I want to use 10060 and another coder says
SEXUALLY TRANSMITTED INFECTIONS Laminated 20 x 26, Describes and illustrates the following STIs: genital warts, genital herpes, chancroid, syphi
Male : Indurated testes. Nocturnal emissions. Impotency. Onanism (in sycotic children). Handling (Stra.). Chancroids, metastasing into warts. Gleets. Enlarged prostate.
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The best pimples to pop are small whiteheads, blackheads, and pustules (looks like a whitehead, but the skin around is red and inflamed). Whiteheads appear when dead skin cells, oil, and bacteria are trapped in your pores. Blackheads are similar in that they are caused by a clogged pore, but the fundamental difference is that with whiteheads, the pore remains closed as compared to blackheads in which the pore is open. Pustules are small bumps on the skin that contain pus or fluid. The safest type to extract at home are the ones which have collected a small amount of pus or keratin in the middle and are very close to the surface of skin, and those that are not very red or deep: these are usually simple blackheads, whiteheads, or pustules, says Dr. Nazarian. Its also important to note that you should never touch deep cysts. While it may be very tempting to pop deep cysts, these should ideally be reserved to professionals as they can be difficult to treat due to the depth of the active lesion, ...
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A pustule on the skin often heals after it drains. However, a pustule in your coronary artery results in a different outcome. When it releases its contents into the bloodstream, a blood clot forms around it and often leads to a heart attack. Reducing inflammation is a key component in the strategy of preventing heart attacks. ...
pock definition: A pustule brought on by smallpox or a similar eruptive disease.; A mark or scar remaining within the epidermis by such a pustule; a pockmark.; To mark with pocks; pit.; A pus filled inflammation…
Olsen, J. and Cowell, G. M. and Konigshofer, E. and Danielsen, E. M. and Moller, J. and Laustsen, L. and Hansen, O. C. and Welinder, K. G. and Engberg, J. and Hunziker, W. and Spiess, Martin and Sjostrom, H. and Noren, O. ...
Cole, L. E.; Kawula, T. H.; Toffer, K. L.; Elkins, C. (2002). "The Haemophilus ducreyi Serum Resistance Antigen DsrA Confers ... White, C. D.; Leduc, I.; Olsen, B.; Jeter, C.; Harris, C.; Elkins, C. (2005). "Haemophilus ducreyi Outer Membrane Determinants ... Elkins, C.; Morrow Jr, K. J.; Olsen, B. (2000). "Serum Resistance in Haemophilus ducreyi Requires Outer Membrane Protein DsrA ... Leduc, I.; Olsen, B.; Elkins, C. (2008). "Localization of the Domains of the Haemophilus ducreyi Trimeric Autotransporter DsrA ...
Haemophilus ducreyi infections can cause skin conditions that mimic primary yaws. People infected with Haemophilus ducreyi ... It seems that a recently diverged strain of Haemophilus ducreyi has evolved from being a sexually transmitted infection to ... Lewis, David A.; Mitjà, Oriol (February 2016). "Haemophilus ducreyi: from sexually transmitted infection to skin ulcer pathogen ...
... the SiaPQM TRAP transporter from Haemophilus influenzae and the SatABCD ABC transporter from Haemophilus ducreyi. Neuraminic ... Post DM, Mungur R, Gibson BW, Munson RS Jr (2005). "Identification of a novel sialic acid transporter in Haemophilus ducreyi". ... "Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance and is ...
Lewis, David A (2014). "Epidemiology, clinical features, diagnosis and treatment of Haemophilus ducreyi - a disappearing ...
Martin PR, Shea RJ, Mulks MH (February 2001). "Identification of a plasmid-encoded gene from Haemophilus ducreyi which confers ... was first isolated in Haemophilus ducreyi, it was found to exhibit significant homology to the mammalian PBEF gene. Rongvaux et ...
Many of these bacteria, including Shigella dysenteriae, Haemophilus ducreyi, and Escherichia coli, infect humans. Bacteria that ... Medically important CDT producers include: Haemophilus ducreyi (chancroids) Aggregatibacter actinomycetemcomitans ( ... This paper was followed by a 1999 publication in Infectious Immunity, which demonstrated that H. ducreyi CDT causes cell death ... HducCDT for Haemaphilus ducreyi CDT). CDT toxins are genotoxins capable of directly damaging DNA in target cells. They are the ...
Main focus was on such bacteria as Haemophilus influenzae, H. ducreyi, and Streptococcus sp. Bordetella pertussis 1. She was a ... "Antibodies to Haemophilus influenzae and their bactericidal activity" (Ph.D. in Microbiology). She was 1988-1989 a post-doc at ...
He is particularly known for his studies of the chancroid and the coccobacillus haemophilus ducreyi. He was the father of ...
Haemophilus ducreyi, Mannheimia haemolytica and Haemophilus parasuis, was supported by 9 CSIs. Based on these results, it was ... Haemophilus influenzae and Haemophilus somnus, was supported by 13 CSIs. Clade II, encompassing Actinobacillus pleuropneumoniae ...
Haemophilus ducreyi, another medically important Gram-negative coccobacillus, is observed in sexually transmitted disease, ... Haemophilus influenzae, Gardnerella vaginalis, and Chlamydia trachomatis are coccobacilli. Aggregatibacter ...
The Eib immunoglobulin-binding proteins from Escherichia coli were third, followed by the DsrA proteins of Haemophilus ducreyi ...
Other homologues have been found in Burkholderia species, Escherichia coli, Haemophilus ducreyi, Mannheimia species, ... Haemophilus ducreyi and Kingella kingae). N-linked glycosylation is an important process, especially in eukaryotes where over ... Haemophilus influenzae has an additional HMW1C homologue HMW2C, which together with the adhesin HMW2 forms a similar substrate- ... in Haemophilus influenzae and identified as a novel type of glycosyltransferase in 2010. The Actinobacillus pleuropneumoniae N- ...
Skin ulcers can resemble those caused by leishmaniasis, yaws, squamous cell carcinoma, Haemophilus ducreyi infection, and ...
... area Inner thighs Chancroid is a bacterial infection caused by the fastidious Gram-negative streptobacillus Haemophilus ducreyi ... H. ducreyi enters skin through microabrasions incurred during sexual intercourse. The incubation period of H.ducreyi infection ... Chancroid, caused by H. ducreyi has infrequently been associated with cases of Genital Ulcer Disease in the US, but has been ... From bubo pus or ulcer secretions, H. ducreyi can be identified using special culture media; however, there is a ...
Chancroid (Haemophilus ducreyi) Chlamydia (Chlamydia trachomatis) Gonorrhea (Neisseria gonorrhoeae), colloquially known as "the ...
... and haemophilus ducreyi (culture on special media currently not widely available in most hospital systems) if the individual is ... While rates of H. ducreyi infection seem to be declining according to a 2017 report, it is possible this may be due to lack of ... testing since H. ducreyi requires a very specialized culture medium which is not commonly available. Less common causes include ...
... urethritis caused by Ureaplasma urealyticum Relapsing fever due to Borrelia recurrentis Chancroid caused by Haemophilus ducreyi ... while some Haemophilus spp., Mycoplasma hominis, and Pseudomonas aeruginosa have developed resistance to varying degrees. It is ... infections Respiratory tract infections caused by Haemophilus influenzae Respiratory tract and urinary tract infections caused ...
... pneumoniae Streptococcus pyogenes Aerobic and facultative Gram-negative microorganisms Haemophilus ducreyi Haemophilus ...
Mycoplasma hominis Mycoplasma pneumoniae Pseudomonas aeruginosa Haemophilus ducreyi Sulfatide acts as a glycolipid receptor ... Haemophilus influenzae, Bordetella pertussis, Mycoplasma pneumoniae, Moraxella catarrhalis, and Pseudomonas aeruginosa cause ... Enterotoxigenic Escherichia coli TOP10 strain Campylobacter jejuni Mycoplasma hyopneumoniae Haemophilus influenzae ...
Haemophilus ducreyi) Chlamydia (Chlamydia trachomatis) Gonorrhea (Neisseria gonorrhoeae) Granuloma inguinale or (Klebsiella ...
... vaginalis Haemophilus Haemophilus ducreyi Haemophilus influenzae Haemophilus parainfluenzae Haemophilus pertussis Haemophilus ...
Treponema pallidum Chancroid is a lesion typical of infection with the bacterium Haemophilus ducreyi Chancres are typically ...
Haemophilus MeSH B03.440.450.600.450.125 - Haemophilus ducreyi MeSH B03.440.450.600.450.330 - Haemophilus influenzae MeSH ... Haemophilus MeSH B03.660.250.550.290.125 - Haemophilus ducreyi MeSH B03.660.250.550.290.330 - Haemophilus influenzae MeSH ... Haemophilus paraphrophilus MeSH B03.440.450.600.450.700 - Haemophilus parasuis MeSH B03.440.450.600.450.750 - Haemophilus ... Haemophilus paraphrophilus MeSH B03.660.250.550.290.700 - Haemophilus parasuis MeSH B03.660.250.550.290.750 - Haemophilus ...
... and Haemophilus ducreyi which causes chancroid. Certain C. jejuni LPS serotypes (attributed to certain tetra- and ... and Haemophilus spp. The term is synonymous with the low molecular weight form of bacterial LPS. LOS plays a central role in ... Haemophilus somnus, a pathogen of cattle, has also been shown to display LOS phase variation, a characteristic which may help ... Howard MD, Cox AD, Weiser JN, Schurig GG, Inzana TJ (2000). "Antigenic diversity of Haemophilus somnus lipooligosaccharide: ...
Murphy, Timothy F. (2020). "Haemophilus Species, Including H. influenzae and H. ducreyi (Chancroid)". Mandell, Douglas, and ... "Haemophilus influenzae". NCBI Taxonomy Browser. 727. Type strain of Haemophilus influenzae at BacDive - the Bacterial Diversity ... Biology portal Hattie Alexander Haemophilus influenzae cellulitis Haemophilus meningitis Maurice Hilleman Pasteurellaceae ... "Haemophilus influenzae type B (HiB)". Health Topics A to Z. Retrieved 2011-03-29. Jin Z, Romero-Steiner S, Carlone GM, Robbins ...
"Haemophilus ducreyi". NCBI Taxonomy Browser. 730. Type strain of Haemophilus ducreyi at BacDive - the Bacterial Diversity ... Haemophilus ducreyi is a fastidious gram-negative coccobacillus bacteria. It causes the sexually transmitted disease chancroid ... H. ducreyi gram stain resembles a "school of fish." H. ducreyi is an opportunistic microorganism that infects its host by way ... Sexually transmitted disease Lewis, DA; Mitjà, O (February 2016). "Haemophilus ducreyi: from sexually transmitted infection to ...
2005). "Identification of a novel sialic acid transporter in Haemophilus ducreyi.". Infect Immun 73 (10): 6727-35. PMID ... i SatABCD ABC transporter iz Haemophilus ducreyi.[8] Reference[uredi - уреди , uredi izvor]. *↑ Li Q, Cheng T, Wang Y, Bryant ... Brojni trasporteri su poznati uklučujući NanT protein iz Escherichia coli,[6] SiaPQM TRAP transporter iz Haemophilus influenze[ ... 2005). "Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance ...
... ducreyi, the causative agent of chancroid. All members are either aerobic or facultatively anaerobic. This genus has been found ... Alternatively, Haemophilus is sometimes cultured using the "Staph streak" technique: both Staphylococcus and Haemophilus ... Members of the genus Haemophilus will not grow on blood agar plates, as all species require at least one of these blood factors ... While Haemophilus bacteria are typically small coccobacilli, they are categorized as pleomorphic bacteria because of the wide ...
Haemophilus ducreyi, Haemophilus parasuis, and Mannheimia haemolytica. Molecular signatures in the form of CSIs have also been ... Haemophilus influenzae, Haemophilus somnus, and Mannheimia succiniciproducens, while the other includes Actinobacillus minor, ... Haemophilus influenzae was the first organism to have its genome sequenced and has been studied intensively by genetic and ... The genus Haemophilus is a notorious human pathogen associated with bacteremia, pneumonia, meningitis and chancroid. Other ...
H. ducreyi. H. felis. H. haemolyticus. H. influenzae. H. paracuniculus. H. parahaemolyticus. H. pittmaniae. H. somnus. etj. ... Pasi që nuk është riklasifikuar në një gjini tjetër H. ducreyi do të diskutohet në këtë kapitull. Haemophilus aphrophilus është ... H. parainfluenzae përbën 10% të florës bakteriale të pështymës, dhe Haemophilus aphrophilus, Haemophilus paraphrophilus, dhe ... Musher DM (1996). Haemophilus Species. In: Baron's Medical Microbiology (Barron S et al, eds.) (4th ed.). Univ of Texas Medical ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ...
Medizinisch bedeutsame Cdt-produzierende Bakterien sind Haemophilus ducreyi, Aggregatibacter actinomycetemcomitans, Escherichia ...
Chancroid (Haemophilus ducreyi). *Chlamydia, lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis (Klebsiella ... Haemophilus influenzae cellulitis. *Pseudomonal pyoderma / Pseudomonas hot-foot syndrome / Hot tub folliculitis / Ecthyma ...
Kankroid (Haemophilus ducreyi) • Klamidia (Chlamydia trachomatis) • Donovanosis (Granuloma Inguinale) • Lymphogranuloma ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ...
Chancroid (Haemophilus ducreyi). *Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma ...
Haemophilus: H. influenzae (Haemophilus meningitis, Brazilian purpuric fever) · H. ducreyi (Chancroid) H. parainfluenzae (HACEK ...
Kankroid (Haemophilus ducreyi) • Klamidia (Chlamydia trachomatis) • Donovanosis (Granuloma Inguinale) • Lymphogranuloma ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ...
Chancroid (Haemophilus ducreyi). *Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma ...
Chancroid (Haemophilus ducreyi). *Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma ...
Chancroide (Haemophilus ducreyi). *Clamidia (Chlamydia trachomatis). *Gonorrea (Neisseria gonorrhoeae). *Granuloma inguinal ( ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ...
軟下疳(杜克雷氏嗜血桿菌(英语:Haemophilus ducreyi)) ...
ޝެންކްރޮއިޑް އަކީ ހީމޯފިލަސް ޑޫކްރައި(Haemophilus ducreyi) ކިޔާ ބެކްޓީރިއާއެއްގެ ސަބަބުން ޖެހޭ ބައްޔެކެވެ. ބަލިޖެހޭތާ 14-4 ...
Chancroid (Haemophilus ducreyi). *Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma ...
Chancroid (Haemophilus ducreyi). *Chlamydia (Chlamydia trachomatis). *Granuloma inguinale or (Klebsiella granulomatis). * ...
Şankroid veya Yumuşak şankr (Haemophilus ducreyi). *Klamidya enfeksiyonu (Chlamydia trachomatis). *Kasık mantarı ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ...
Chancroid (Haemophilus ducreyi). *Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma ...
Chancroid (Haemophilus ducreyi). *Chlamydia, lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis (Klebsiella ...
Chancroid (Haemophilus ducreyi). *Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma ...
Chancroid (Haemophilus ducreyi). *Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma ... Haemophilus influenzae infection Haemophilus influenzae Hand, foot and mouth disease (HFMD) Enteroviruses, mainly Coxsackie A ...
Haemophilus: H. influenzae (Haemophilus meningitis, Brazilian purpuric fever) · H. ducreyi (Chancroid) H. parainfluenzae(HACEK) ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ...
Chancroid (Haemophilus ducreyi). *Chlamydia/Lymphogranuloma venereum (Chlamydia trachomatis). *Donovanosis or Granuloma ...
"Haemophilus ducreyi". NCBI Taxonomy Browser. 730. Type strain of Haemophilus ducreyi at BacDive - the Bacterial Diversity ... Haemophilus ducreyi is a fastidious gram-negative coccobacillus bacteria. It causes the sexually transmitted disease chancroid ... H. ducreyi gram stain resembles a "school of fish." H. ducreyi is an opportunistic microorganism that infects its host by way ... Sexually transmitted disease Lewis, DA; Mitjà, O (February 2016). "Haemophilus ducreyi: from sexually transmitted infection to ...
Experimental human infection with Haemophilus ducreyi.. Spinola SM1, Wild LM, Apicella MA, Gaspari AA, Campagnari AA. ... Four subjects were experimentally infected with Haemophilus ducreyi. Lesions developed only at sites where live bacteria were ... Thus, human experimental infection with H. ducreyi is well tolerated and safe. Recruitment of T cells and macrophages into ... The amount of H. ducreyi recovered from 10 of 12 biopsies that were semiquantitatively cultured varied widely. Similar ...
Haemophilus ducreyi definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look ... Haemophilus aegyptius, Haemophilus ducreyi, Haemophilus influenzae, Haemophilus influenzae type b, Haemophilus influenzae type ... Words nearby Haemophilus ducreyi. haemophilia, haemophiliac, haemophilic, Haemophilus, ...
Complete Genome Sequence of Haemophilus somnus (Histophilus somni) Strain 129Pt and Comparison to Haemophilus ducreyi 35000HP ... Haemophilus ducreyi Secretes a Filamentous Hemagglutinin-Like Protein Christine K. Ward, Sheryl R. Lumbley, Jo L. Latimer, ... Identification of a Plasmid-Encoded Gene fromHaemophilus ducreyi Which Confers NAD Independence Paul R. Martin, Robin J. Shea, ... Comparative Proteomic Analysis of the Haemophilus ducreyi Porin-Deficient Mutant 35000HP::P2AB Jeremiah J. Davie, Anthony A. ...
Antibodies directed against Haemophilus ducreyi heat shock proteins.. Brown TJ1, Jardine J, Ison CA. ... The response to heat shock in Haemophilus ducreyi has been investigated by labelling newly synthesized proteins with a pulse of ... The HSP of 58.5 kDa appears to be immunogenic and may play a part in the host response to H. ducreyi and the pathogenesis of ... The three larger proteins appeared to be independently controlled and inducible in a range of H. ducreyi strains. The protein ...
... ducreyi loci, including virulence and housekeeping genes, which encompass approximately 1% of the H. ducreyi genome. Sequences ... Recent studies done in yaws-endemic areas of the South Pacific have shown that H. ducreyi is also a major cause of cutaneous ... The CLU strains divergence falls after the divergence of humans from chimpanzees, making it the first known H. ducreyi ... Phylogenetic analyses suggest that these non-sexually transmitted strains of H. ducreyi comprise a sub-clonal population within ...
Genomic DNA from Haemophilus ducreyi 35000HP TypeStrain=False Application: ... Haemophilus ducreyi (Neveu-Lamaire) Bergey et al. (ATCC® 700724D-5™) Strain Designations: Genomic DNA from Haemophilus ducreyi ... Haemophilus ducreyi (Neveu-Lamaire) Bergey et al. ATCC® 700724D-5™ dried Total DNA: At least 5 µg in 1X TE buffer ... Genomic DNA from Haemophilus ducreyi 35000HP [ATCC® 700724™] Biosafety Level 1 Biosafety classification is based on U.S. Public ...
Haemophilus ducreyi, also known as H. ducreyi, is a fastidious, Gram-negative, coccobacillus that causes the sexually ... Gram-negative Haemophilus ducreyi bacteria, which had been extracted from a culture. From Public Health Image Library (PHIL). [ ... Gram-negative Haemophilus ducreyi bacteria, which had been extracted from a culture. From Public Health Image Library (PHIL). [ ... Gram-negative Haemophilus ducreyi bacteria arranged in parallel rows. From Public Health Image Library (PHIL). [6] ...
Haemophilus ducreyi Secretes a Filamentous Hemagglutinin-Like Protein. Christine K. Ward, Sheryl R. Lumbley, Jo L. Latimer, ... Haemophilus ducreyi Secretes a Filamentous Hemagglutinin-Like Protein. Christine K. Ward, Sheryl R. Lumbley, Jo L. Latimer, ... Haemophilus ducreyi Secretes a Filamentous Hemagglutinin-Like Protein. Christine K. Ward, Sheryl R. Lumbley, Jo L. Latimer, ... Evidence of Haemophilus ducreyi adherence to and cytotoxin destruction of human epithelial cells.Microb. Pathog.141993417431. ...
Umfassende Darstellung von medizinischen Laborparametern. Mehr als die H lfte aller Erkrankungen werden durch Laborparameter entdeckt oder im Verlauf kontrolliert.
sp,Q7VMH0,BIOB_HAEDU Biotin synthase OS=Haemophilus ducreyi (strain 35000HP / ATCC 700724) OX=233412 GN=bioB PE=3 SV=1 ... Haemophilus ducreyi (strain 35000HP / ATCC 700724). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_ ... Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae). Actinobacillus pleuropneumoniae serotype 5b (strain L20). ... cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › ...
Haemophilus sp. C1. Haemophilus haemolyticus M19501. Haemophilus haemolyticus M21127. Haemophilus influenzae R3021. Haemophilus ... Haemophilus influenzae NT127. Haemophilus influenzae. Haemophilus haemolyticus. Haemophilus haemolyticus M21621. ... sp,Q7VMW5,LPXB_HAEDU Lipid-A-disaccharide synthase OS=Haemophilus ducreyi (strain 35000HP / ATCC 700724) OX=233412 GN=lpxB PE=3 ... Haemophilus ducreyi (strain 35000HP / ATCC 700724). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_ ...
Isolation of H. ducreyi in low-income settings is challenging, limiting phylogenetic investigation. Next-generation sequencing ... demonstrates that cutaneous strains arise from class I and II H. ducreyi clades and that class II may represent a distinct ... Haemophilus ducreyi, which causes chancroid, has emerged as a cause of pediatric skin disease. ... Haemophilus ducreyi, which causes chancroid, has emerged as a cause of pediatric skin disease. Isolation of H. ducreyi in low- ...
... primarily Haemophilus ducreyi. We developed a novel molecular test to simultaneously detect T. pallidum and H. ducreyi based on ... We validated the T. pallidum and H. ducreyi LAMP (TPHD-LAMP) by testing 293 clinical samples from patients with yaws-like ... ducreyi DNA and might be suitable for use at the point of care. TPHD-LAMP could support yaws eradication by improving access to ... ducreyi (91.6% sensitivity, 84.8% specificity). This novel assay provided rapid molecular confirmation of T. pallidum and H. ...
Binding of Haemophilus ducreyi to Extracellular Matrix Proteins Message Subject (Your Name) has forwarded a page to you from ... Binding of Haemophilus ducreyi to Extracellular Matrix Proteins. Margaret E. Bauer, Stanley M. Spinola ... Effect of normal and immune sera on Haemophilus ducreyi 35000HP and its isogenic MOMP and LOS mutants.Microb. Pathog.26199993 ... Haemophilus ducreyiis the causative agent of chancroid, a sexually transmitted genital ulcer disease that facilitates the ...
Haemophilus ducreyi PCR is a referred out test. Specimens will be shipped to the National Microbiology Laboratory (NML) in ... Specimens submitted for Haemophilus ducreyi molecular detection by PCR are shipped every Thursday to the NML for testing. ... Documentation must include clinical background leading to suspicion of H. ducreyi infection in a patient, including any ... additional factors that may increase the probability of H. ducreyi infection. Chancroid is endemic in southeast Asia and Africa ...
The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src ... Haemophilus ducreyi causes chancroid, a sexually transmitted infection. A primary means by which this pathogen causes disease ... Haemophilus ducreyi, a sexually transmitted pathogen, secretes a 4,153-amino-acid (aa) protein (LspA1) that effectively ... The ability to inhibit phagocytosis via Csk is not unique to H. ducreyi, because we found that the Helicobacter pylori CagA ...
Haemophilus ducreyi. SYNONYM OR CROSS REFERENCE: Bacillus of Unna-Ducrey (1), The bacillus of Ducrey, Coccobacillus ducreyi (2) ... Pathogen Safety Data Sheets: Infectious Substances - Haemophilus ducreyi. PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES. ... Hobbs, M. M., San Mateo, L. R., Orndorff, P. E., Almond, G., & Kawula, T. H. (1995). Swine model of Haemophilus ducreyi ... Trees, D. L., & Morse, S. A. (1995). Chancroid and Haemophilus ducreyi: an update. Clinical Microbiology Reviews, 8(3), 357-375 ...
Haemophilus ducreyi attaches to and invades human epithelial cells in vitro.. P A Totten, J C Lara, D V Norn, W E Stamm ... Haemophilus ducreyi attaches to and invades human epithelial cells in vitro. Message Subject (Your Name) has forwarded a page ... Haemophilus ducreyi is a sexually transmitted pathogen that causes genital ulcers and inguinal adenopathy. Because chancroidal ... ducreyi with its host. The eight different strains of H. ducreyi that were studied varied in their abilities to attach to these ...
Table 1. In vitro Sensitivities of Haemophilus ducreyi (13, 18, 30, 33). Antimicrobial Agent. MIC50 (mg/mL). MIC90 (mg/mL). MIC ... Haemophilus ducreyi (Chancroid). Authors: Pierre J. Plourde, M.D., FRCPC, and Allan Ronald, O.C., M.D., FRCPC ... Haemophilus ducreyi causing chronic skin ulceration in children visiting Samoa. Clin Infect Dis 2007;44:e85-e87. [PubMed] ... Haemophilus ducreyi associated with skin ulcers among children, Solomon Islands. Emerg Infect Dis 2014;20:1705-1707. [PubMed] ...
Evaluation of multiplex real-time PCR for detection of Haemophilus ducreyi, Treponema pallidum, herpes simplex virus type 1 and ... Table 1 Patient demographics and distribution of Haemophilus ducreyi (HD), Treponema pallidum (TP), herpes simplex virus type 1 ... Simultaneous PCR detection of Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus types 1 and 2 from genital ... Evaluation of multiplex real-time PCR for detection of Haemophilus ducreyi, Treponema pallidum, herpes simplex virus type 1 and ...
Keywords: Haemophilus ducreyi, Phosphoethanolamine Transferase, Antimicrobial Peptide Resistance Abstract:. Haemophilus ducreyi ... Phosphoethanolamine transferases in Haemophilus ducreyi modify lipid A and contribute to human defensin resistance. Login ... Phosphoethanolamine transferases in Haemophilus ducreyi modify lipid A and contribute to human defensin resistance. Trombley, ... H. ducreyi LOS has PEA modifications at two sites, and we identified three genes (lptA, ptdA, and ptdB) in H. ducreyi with ...
Haemophilus ducreyi is a Gram-negative, facultative anaerobic bacillus that is the cause of chancroid, which is endemic in sub- ... p. 763) Haemophilus ducreyi and chancroid. Chapter:. (p. 763) Haemophilus ducreyi and chancroid. Author(s):. Nigel OFarrell. ... Haemophilus ducreyi is a Gram-negative, facultative anaerobic bacillus that is the cause of chancroid, which is endemic in sub- ...
... ducreyi, smears taken from skin lesions of mice infected with H. ducreyi and patients from South Africa, Thailand and Malaysia ... It detected H. ducreyi in 95% of the animal lesions compared with 14% detected by culture. Immunofluorescence testing ... These results suggest that this antibody may provide a simple, rapid and sensitive means of detecting H. ducreyi in cases of ... A monoclonal antibody raised against Haemophilus ducreyi was tested for its sensitivity and specificity as an ...
The Microbe collection is a diverse group of mAbs that recognize primarily surface components of prokaryotes including bacteria and viruses
Haemophilus ducreyi) case definition; uniform criteria used to define a disease for public health surveillance. ... The disease is caused by infection with Haemophilus ducreyi.. Laboratory Criteria For Diagnosis Isolation of H. ducreyi from a ... Chancroid (Haemophilus ducreyi). 1996 Case Definition. NOTE: A surveillance case definition is a set of uniform criteria used ...
The bacterium Haemophilus ducreyi causes this infection. It attacks. SUMMARY. ... CHANCROIDE HAEMOPHILUS DUCREYI PDF - Chancroid is a bacterial infection that causes open sores on the genitals. ... The bacterium Haemophilus ducreyi causes this infection. It attacks. SUMMARY. Haemophilus ducreyi is a fastidious gram-negative ... Chancroid and Haemophilus ducreyi.. Retrieved 30 June Antimicrobial susceptibility udcreyi Haemophilus ducreyi. Zentralbl ...
The bacterium Haemophilus ducreyi causes this infection. It attacks. SUMMARY. ... CHANCROIDE HAEMOPHILUS DUCREYI PDF - Chancroid is a bacterial infection that causes open sores on the genitals. ... The bacterium Haemophilus ducreyi causes this infection. It attacks. SUMMARY. Haemophilus ducreyi is a fastidious gram-negative ... Chancroid and Haemophilus ducreyi.. How to Use Condoms Safely If youre relying on condoms only to prevent pregnancy, you want ...
Chancroid (Haemophilus ducreyi) , 1996 Case Definition (https://wwwn.cdc.gov/nndss/conditions/chancroid/case-definition/1996/) ... Chancroid (Haemophilus ducreyi) , 1990 Case Definition (https://wwwn.cdc.gov/nndss/conditions/chancroid/case-definition/1990/) ...
The disease is caused by infection with Haemophilus ducreyi.. Laboratory Criteria for Diagnosis. Isolation of H. ducreyi from a ... Chancroid (Haemophilus ducreyi) , 1996 Case Definition (https://wwwn.cdc.gov/nndss/conditions/chancroid/case-definition/1996/) ...
  • H. ducreyi causes chancroid by secreting several virulence factors , the most well-characterized being fimbrialike protein (Flp) and H. ducreyi cytolethal distending toxin (HdCDT). (wikidoc.org)
  • Wising C, Azem J, Zetterberg M, Svensson LA, Ahlman K, Lagergard T. Induction of apoptosis/necrosis in various human cell lineages by Haemophilus ducreyi cytolethal distending toxin. (medscape.com)
  • RepoKERWA133282018-06-20T16:58:01Z The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA Frisan, Teresa Cortés Bratti, Ximena Chaves Olarte, Esteban Stenerlöw, Bo Thelestam, Mónica ADN (Citosina-5-) Metiltransferasa Salud pública Genética humana Artículo científico -- Universidad de Costa Rica. (csuca.org)
  • Induction of apoptosis/necrosis in various human cell lineages by Haemophilus ducreyi cytolethal distending toxin. (gu.se)
  • Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, produces a cytolethal distending toxin (HdCDT) that inhibits cultured cell proliferation, leading to cell death. (gu.se)
  • Haemophilus ducreyi, which causes chancroid, has emerged as a cause of pediatric skin disease. (cdc.gov)
  • Haemophilus ducreyi causes chancroid, a sexually transmitted infection. (sigmaaldrich.com)
  • Haemophilus ducreyi is a strict human pathogen that causes chancroid, a genital ulcer disease (GUD) that facilitates the transmission of the human immunodeficiency virus (HIV-1). (grantome.com)
  • Haemophilus ducreyi causes chancroid, which facilitates transmission of human immunodeficiency virus type 1. (elsevier.com)
  • Haemophilus ducreyi is a fastidious gram-negative coccobacillus bacteria. (wikipedia.org)
  • Usually, gram negative bacteria cell walls contain lipopolysaccharides, but the H. ducreyi cell wall lacks the O-antigen ( 11 ) . (canada.ca)
  • Haemophilus ducreyi bacteria - the causative agent of chancroid, stained with Gentian Violet. (lecturio.com)
  • DescriptionAPI en:Haemophilus influenzae bacteria cultured on a blood en:agar plate . (eol.org)
  • Lagergård T, Bölin I, Lindholm L. On the evolution of the sexually transmitted bacteria Haemophilus ducreyi and Klebsiella granulomatis. (medscape.com)
  • A rabbit model of dermal infection was used to investigate the roles of H. ducreyi bacteria and HdCDT in the development, clinical appearance, and persistence of infection. (gu.se)
  • Chancroid is an STI caused by the haemophilus ducreyi bacteria. (medicalnewstoday.com)
  • Haemophilus parasuis is known as a commensal organism discovered in the upper respiratory tract of swine where the pathogenic bacteria survive in various adverse environmental stress. (frontiersin.org)
  • H.ducreyi appears to be a significant alternative etiology of chronic ulcers among children who have been assumed to have yaws due to Treponema pallidum subspecies pertenue . (antimicrobe.org)
  • To develop a real-time PCR assay that reliably and accurately detects the predominant sexually transmitted aetiological agents of genital ulcer disease (GUD) ( Haemophilus ducreyi , Treponema pallidum and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2)) and to assess the use of real-time PCR diagnostic testing in a rural African field site. (bmj.com)
  • 1 These STIs frequently present as genital ulcer disease (GUD) of which the predominant aetiological agents are Haemophilus ducreyi (chancroid), Treponema pallidum (syphilis) and herpes simplex virus type 2 (HSV-2). (bmj.com)
  • Isolation and rapid identification of Haemophilus ducreyi. (local-travel.info)
  • Identification of Haemophilus ducreyi genes expressed during human infection. (medigraphic.com)
  • abstract = "Pooled sera from patients with chancroid contain antibodies to a Haemophilus ducreyi antigen with an approximate molecular weight of 28,000 (28K). (elsevier.com)
  • Haemophilus ducreyi strain 35000HP complete genome. (atcc.org)
  • H. ducreyi 35000HP bound to fibronectin, laminin, and type I and III collagen but not to type IV, V, or VI collagen or elastin. (asm.org)
  • We chose H. ducreyi 35000HP for these studies. (asm.org)
  • H. ducreyi 35000HP ( 2 ) was grown in broth with fetal calf serum to mid-log phase as described previously ( 6 ), harvested by centrifugation, and washed and suspended in PBS to the desired optical density at a wavelength of 660 nm (OD 660 ). (asm.org)
  • Phylogenetic tree of Haemophilus ducreyi genome sequences inferred from mapping using the H. ducreyi 35000HP strain as reference and after removing high-density single-nucleotide polymorphisms regions with Gubbins ( 3 ). (cdc.gov)
  • Comparative analysis of the global gene expression of a Haemophilus ducreyi 35000HP cpxA deletion mutant relative to the wild type strain Overall design: After the cpxA mutant was generated, both strain were grown in Columbia Broth. (omicsdi.org)
  • H. ducreyi is typically transmitted through sexual intercourse but certain strains my also cause non-sexually transmitted cutaneous limb ulcers (CLU). (wikidoc.org)
  • H. ducreyi is an emerging cause of cutaneous ulcers in tropical countries ( 1 - 4 ). (cdc.gov)
  • Haemophilus ducreyi is a sexually transmitted pathogen that causes genital ulcers and inguinal adenopathy. (asm.org)
  • Because chancroidal ulcers are most commonly located on the foreskins of uncircumcised males, we utilized human foreskin epithelial cells (HFECs) to investigate the initial interaction of H. ducreyi with its host. (asm.org)
  • Since 2005, H. ducreyi has been newly identified as a cause of chronic skin ulcers in children living in yaws-endemic areas of the South Pacific region ( 20 , 24 , 39 ). (antimicrobe.org)
  • First described in 1989 as the cause of a lower extremity chronic ulcer in an adult male ( 19 ), until recently there had only been a handful of cases of non-sexually transmitted chronic skin ulcers caused by H. ducreyi reported in the literature ( 23 , 26 , 39 ). (antimicrobe.org)
  • Much less is known about the presentation and natural history of H. ducreyi as a cutaneous infection described in the South Pacific region presenting as chronic lower extremity ulcers among children living in yaws-endemic areas ( 20 , 24 , 39 ). (antimicrobe.org)
  • Individual case reports of H. ducreyi causing lower extremity ulcers have been reported since 1989 in Australia and New Zealand in South Sea Islanders ( 19, 23 , 26 , 39 ). (antimicrobe.org)
  • The survey in Papua New Guinea found H. ducreyi to be the probable cause of almost 80% of these chronic ulcers in children. (antimicrobe.org)
  • Two multiplex real-time PCR reactions were used to detect H ducreyi /and HSV-1/HSV-2 in ulcer swabs from 100 people with symptomatic genital ulcers in rural Rakai, Uganda. (bmj.com)
  • Localization of Haemophilus ducreyi in naturally acquired chancroidal ulcers. (local-travel.info)
  • Pathogenic microbial flora of genital ulcers in Sheffield with particular reference to herpes simplex virus and Haemophilus ducreyi. (aprel-reklama.ru)
  • The chronic use of antibiotics for the treatment of genital ulcers has led to the emergence of widespread resistant strains of H. ducreyi in developing countries. (lecturio.com)
  • The patients with H. ducreyi ulcers may give a history of unprotected sex with multiple partners and prostitutes. (lecturio.com)
  • Sequences from cutaneous ulcers in Ghana and the Solomon Islands were found within both previously described clades of H. ducreyi class I and class II. (cdc.gov)
  • The following regimens (given three times daily for seven days) were compared in a double-blind randomised trial--amoxycillin 500 mg, amoxycillin 500 mg and clavulanic acid 125 mg, and amoxycillin 500 mg and clavulanic acid 250 mg. 68 of 100 ulcers were culture-positive for H. ducreyi. (ac.ke)
  • At day 7 none of the amoxycillin-treated patients had responded clinically or bacteriologically, whereas all but 2 of 56 patients treated with an amoxycillin/clavulanic-acid regimen had responded clinically and H. ducreyi had been eradicated from their ulcers. (ac.ke)
  • Co-administration of HdCDT resulted in significant aggravation of H. ducreyi-induced inflammatory lesions, and development of ulcers in rabbit skin. (gu.se)
  • In conclusion, H. ducreyi causes a pronounced, chronic inflammation with involvement of T cells and macrophages, and in combination with HdCDT production of ulcers in the rabbit model. (gu.se)
  • More recently, related toxins have been identified in Haemophilus ducreyi , a human pathogen responsible for the formation of chancroid ulcers and buboes, and A. actinomycetemcomitans strains Y4 and 652 ( 17 , 18 ). (jimmunol.org)
  • The HSP of 58.5 kDa appears to be immunogenic and may play a part in the host response to H. ducreyi and the pathogenesis of chancroid. (nih.gov)
  • Much remains unknown concerning the pathogenesis of chancroid and the factors produced by H. ducreyi which enable this bacterium to cause disease. (asm.org)
  • Therefore, it is likely that early steps in the pathogenesis of chancroid involve the adherence of H. ducreyi to host cells and extracellular matrix components located below the keratinized epithelium. (asm.org)
  • Further examination of the mechanisms involved in the adherence and invasion of H. ducreyi into epithelial cells and their correlation with virulence will provide a better understanding of the pathogenesis of the disease caused by this important pathogen. (asm.org)
  • While this is the first identified mechanism of resistance to α-defensins in H. ducreyi, our in vivo data suggest that resistance to cathelicidin may be more important than defensin resistance to H. ducreyi pathogenesis. (iupui.edu)
  • Mutant-parent trials confirmed key features in H. ducreyi pathogenesis, and the model has provided an opportunity to study differential human susceptibility to a bacterial infection. (elsevier.com)
  • Although antigen detection, serology, and genetic amplification methods are sometimes used to diagnose infections with H. ducreyi and the genetic tests have greater sensitivity, they are not widely available, so cultures are currently considered the "gold standard" test. (wikipedia.org)
  • Rapid detection of Haemophilus ducreyi in clinical and experimental infections using monoclonal antibody: a preliminary evaluation. (tropmedres.ac)
  • Haemophilus ducreyi is the causative agent of chancroid, a sexually transmitted genital ulcer disease that facilitates the transmission of human immunodeficiency virus ( 17 ). (asm.org)
  • Haemophilus ducreyi is the causative agent of chancroid, one of the genital ulcerative diseases. (aprel-reklama.ru)
  • The pathogenicity of haemophilus ducreyi, the etiological agent of chancroid is poorly understood. (wits.ac.za)
  • Multiresistant strains of Haemophilus ducreyi, the aetiological agent of chancroid, are prevalent in Nairobi, Kenya, where tetracyclines and sulphonamides are no longer very effective in the treatment of chancroid. (ac.ke)
  • Reverse transcriptase PCR analysis of total RNA isolated from H. ducreyi 35000 grown in liquid medium, grown on solid agar medium, and isolated from lesions of H. ducreyi -infected rabbits indicated that lspA1 and lspA2 were transcribed both in vitro and in vivo. (asm.org)
  • Four H. ducreyi strains, previously shown to be avirulent in the temperature-dependent rabbit model for chancroid, did not produce either LspA1 or LspA2 in vitro. (asm.org)
  • Consistent with these observations, H. ducreyi is reported to adhere to and invade several different human cell lines in vitro ( 2-4 , 12 , 31 , 32 , 53 , 55 , 58 ) as well as to bind extracellular matrix components ( 1 , 11 ). (asm.org)
  • Expression of wild-type LOS appears to be essential for maximal attachment of H. ducreyi to human foreskin fibroblasts (HFF) and keratinocytes in vitro ( 21 ), but there is some evidence that other proteinaceous factors also may be involved ( 3 , 20 , 39 ). (asm.org)
  • Haemophilus ducreyi attaches to and invades human epithelial cells in vitro. (asm.org)
  • In vitro culture of H ducreyi is difficult and often impractical in clinical and research settings. (bmj.com)
  • Origin and direction of in vitro replication of Haemophilus ducreyi and Neisseria gonorrhoeae ampicillin resistance plasmids. (local-travel.info)
  • In the last funding period, we found that several hundred bacterial genes were differentially regulated in vivo relative to in vitro growth, suggesting that H. ducreyi senses and responds to the adverse host environment. (grantome.com)
  • Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, has been shown to inhibit phagocytosis of both itself and secondary targets in vitro. (elsevier.com)
  • Characterization of Haemophilus ducreyi cdtA, cdtB, and cdtC Mutants in In Vitro and In Vivo Systems. (sigmaaldrich.com)
  • Haemophilus ducreyi is a fastidious gram-negative coccobacillus causing chancroid , a gential ulcer disease. (wikidoc.org)
  • Haemophilus ducreyi , also known as H. ducreyi , is a fastidious , Gram-negative , coccobacillus that causes the sexually transmitted disease chancroid, characterized as a genital ulcer disease. (wikidoc.org)
  • Chancroid, a sexually transmitted disease characterized by painful genital ulceration, is caused by the fastidious gram-negative bacterium Haemophilus ducreyi ( 60 ). (asm.org)
  • Haemophilus ducreyi, a fastidious gram-negative bacillus is a well-known cause of chancroid, a sexually transmitted pathogen which has been associated with the sexual transmission of human immunodeficiency virus (HIV) ( 32 ). (antimicrobe.org)
  • Haemophilus ducreyi is a fastidious gram-negative bacillus that causes the sexually transmitted infection chancroid. (local-travel.info)
  • Chancroid is a bacterial infection caused by the fastidious Gram-negative streptobacillus Haemophilus ducreyi. (aprel-reklama.ru)
  • Specimens submitted for Haemophilus ducreyi molecular detection by PCR are shipped every Thursday to the NML for testing. (publichealthontario.ca)
  • Refer to external resources - Haemophilus ducreyi Molecular detection by PCR. (publichealthontario.ca)
  • However, the detection of H. ducreyi DNA in ulcer specimens by PCR has been shown to be significantly more sensitive than detection by culture ( 16 , 39 ). (asm.org)
  • A history of the detection of Haemophilus ducreyi, 1889-1979. (medigraphic.com)
  • To investigate if temperature affects the interaction of Haemophilus ducreyi with human epithelial cells, nine strains were used to evaluate the adhesion kinetics of the organism at 33°C and 37°C. The effect of the free toxin on the epithelial cells at those temperatures was also assessed. (microbiologyresearch.org)
  • A non-toxin producing H. ducreyi strain, and for comparison purposes a non-capsulated Haemophilus influenzae strain, were inoculated intradermally, with and without co-administration of purified HdCDT. (gu.se)
  • Histopathological sections of the H. ducreyi-induced lesions, in both the presence and absence of HdCDT, showed dense infiltrates of the same type inflammatory cells, with the exception of a prominent endothelial cell proliferation noted in sections from lesions caused by H. ducreyi and toxin. (gu.se)
  • Signs of chronic inflammation with involvement of T cells, macrophages, eosinophils, and granuloma formation were observed after H. ducreyi inoculation both with and without toxin. (gu.se)
  • Bacillus of Unna-Ducrey ( 1 ) , The bacillus of Ducrey, Coccobacillus ducreyi ( 2 ) , The ducreyi bacillus ( 3 ) , Chancroid ( 4 ) , Ulcus molle ( 5 ) , Soft chancre ( 6 ) . (canada.ca)
  • Haemophilus ducreyi is a Gram-negative, facultative anaerobic bacillus that is the cause of chancroid, which is endemic in sub-Saharan Africa and the Caribbean, although the overall global incidence of the condition has decreased dramatically since the mid 1990s. (oxfordmedicine.com)
  • Haemophilus influenzae (formerly called Pfeiffer's bacillus or Bacillus influenzae) is a Gram-negative, coccobacillary, facultatively anaerobic capnophilic pathogenic bacterium of the family Pasteurellaceae. (wikipedia.org)
  • Chancroid is caused by a bacillus called Haemophilus ducreyi . (netdoctor.co.uk)
  • This finding raised the possibility that LspA1, LspA2, or both may be involved in the ability of H. ducreyi to cause lesions in this animal model. (asm.org)
  • This hypothesis is supported by the finding that H. ducreyi causes chancroidal lesions in humans only when applied to a damaged epithelium ( 55 ). (asm.org)
  • Cutaneous lesions of H. ducreyi are difficult to distinguish from other common causes of ulcerative skin disease, such as yaws ( 3 , 4 ), which presents problems in diagnosing yaws and has resulted in the World Health Organization recommending molecular testing of yaws-like lesions ( 5 ). (cdc.gov)
  • H. ducreyi is transmitted through direct contact with open lesions and exudates from lymph nodes during sexual intercourse ( 8 ) . (canada.ca)
  • A monoclonal antibody raised against Haemophilus ducreyi was tested for its sensitivity and specificity as an immunofluorescence (IF) reagent using simulated vaginal smears containing H. ducreyi, smears taken from skin lesions of mice infected with H. ducreyi and patients from South Africa, Thailand and Malaysia with clinically diagnosed chancroid. (tropmedres.ac)
  • It detected H. ducreyi in 95% of the animal lesions compared with 14% detected by culture. (tropmedres.ac)
  • The diagnosis of H. ducreyi infection is complicated by difficulties encountered in isolating the organism in culture as well as its clinical presentation which can be confused with syphilis, genital herpes viral infection, and more recently with yaws in children ( 20 , 24 ). (antimicrobe.org)
  • In nature, H. ducreyi can only cause illness in humans ( 4 ) , but there are animal models (i.e. macaque ( 13 ) , mouse ( 14 ) and swine ( 15 ) ). (canada.ca)
  • Resistance to LL-37, mediated by the sensitive to antimicrobial peptide (Sap) transporter, is required for H. ducreyi virulence in humans. (iupui.edu)
  • H. ducreyi only affects humans and has no intermediate or secondary hosts. (lecturio.com)
  • Carbon storage regulator A contributes to the virulence of Haemophilus ducreyi in humans by multiple mechanisms. (medscape.com)
  • A fibrinogen-binding lipoprotein contributes to the virulence of Haemophilus ducreyi in humans. (medigraphic.com)
  • However, rRNA analysis indicates H. ducreyi is not a true Haemophilus but is more closely related to the Pasteurellaceae family. (wikidoc.org)
  • A monoclonal antibody, designated 5C9, bound to a 28K outer membrane protein and to 35 of 35 H. ducreyi isolates with diverse geographic origins and did not bind to many species of the families Pasteurellaceae, Neisseriaceae, and Enterobacteriaceae or to Corynebacterium and Candida species strains. (elsevier.com)
  • Multi Locus Sequence Analysis (MLSA) of several virulence factors and housekeeping genes has identified class I and class II strains of H. ducreyi causing chancroid, a sexually transmitted genital ulcer disease. (wikidoc.org)
  • Haemophilus ducreyi causes a genital ulcer disease called chancroid, which facilitates HIV transmission. (grantome.com)
  • The protein profiles were also probed by Western blot with serum from an immunized rabbit, serum from a rabbit infected intradermally with H. ducreyi, mouse monoclonal antibodies (MAb) and a pool of human sera from patients with chancroid. (nih.gov)
  • We have identified two extremely large open reading frames (ORFs) in Haemophilus ducreyi 35000, lspA1 and lspA2 , each of which encodes a predicted protein product whose N-terminal half is approximately 43% similar to the N-terminal half of Bordetella pertussis filamentous hemagglutinin (FhaB). (asm.org)
  • A 260-kDa protein present in culture supernatant from eight virulent H. ducreyi strains reacted with both polyclonal serum from rabbits infected with H. ducreyi 35000 and a monoclonal antibody predicted to bind both LspA1 and LspA2. (asm.org)
  • This 260-kDa protein in H. ducreyi 35000 culture supernatant was shown to be the protein product of the lspA1 ORF based on its reactivity with a monoclonal antibody specific for LspA1. (asm.org)
  • The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase. (sigmaaldrich.com)
  • Here, we report that the LspA virulence factors of H. ducreyi inhibit phagocytosis by stimulating the catalytic activity of C-terminal Src kinase (Csk), which itself inhibits Src family protein tyrosine kinases (SFKs) that promote phagocytosis. (sigmaaldrich.com)
  • Haemophilus ducreyi, a sexually transmitted pathogen, secretes a 4,153-amino-acid (aa) protein (LspA1) that effectively inhibits FcγR-mediated phagocytic activity. (sigmaaldrich.com)
  • The ability to inhibit phagocytosis via Csk is not unique to H. ducreyi, because we found that the Helicobacter pylori CagA protein also inhibits phagocytosis in a Csk-dependent manner. (sigmaaldrich.com)
  • Rabbit polyclonal serum that reacts to a 28K protein can be used to detect H. ducreyi in clinical samples. (elsevier.com)
  • A 5C9-reactive phage was recovered from a genomic library, and the gene encoding the 28K protein was localized to a 626-bp open reading frame, designated hlp, for H. ducreyi lipoprotein. (elsevier.com)
  • Examination of the phosphotyrosine protein profiles of these two sets of macrophages showed that those incubated with wild-type H. ducreyi had greatly reduced phosphorylation levels of proteins in the 50-to-60-kDa range. (elsevier.com)
  • Immunochromatography tests use monoclonal antibodies to the hemoglobin receptor of H ducreyi, hgbA, an outer membrane protein. (medscape.com)
  • Elkins C, Morrow Kj, Olsen B. Serum resistance in Haemophilus ducreyi requires outer membrane protein DsrA. (medigraphic.com)
  • Spinola SM, Bauer ME, Munson RS Jr. Immunopathogenesis of Haemophilus ducreyi infection (chancroid). (medscape.com)
  • The bacterium Haemophilus ducreyi causes this infection. (local-travel.info)
  • Haemophilus ducreyi is a highly infectious bacterium that is transmitted sexually when it gains tissue access via skin microabrasions and mucosal breaks that occur during sexual intercourse. (lecturio.com)
  • Antibodies directed against Haemophilus ducreyi heat shock proteins. (nih.gov)
  • The response to heat shock in Haemophilus ducreyi has been investigated by labelling newly synthesized proteins with a pulse of 35S-methionine at a range of temperatures between 30-40 degrees C. Proteins were then separated by SDS-PAGE and analysed by autoradiography of the resultant profiles. (nih.gov)
  • The three larger proteins appeared to be independently controlled and inducible in a range of H. ducreyi strains. (nih.gov)
  • We developed an enzyme-linked immunosorbent assay-based assay to assess Haemophilus ducreyi binding to extracellular matrix (ECM) proteins. (asm.org)
  • Isogenic strains with mutations in ftpA or losB bound as well as the parent, suggesting that neither pili nor full-length lipooligosaccharide is required for H. ducreyi to bind to ECM proteins. (asm.org)
  • To characterize the binding of H. ducreyi to ECM proteins, we used an enzyme-linked immunosorbent assay (ELISA)-based assay with ECM proteins found in adult human skin, including fibronectin, laminin, several collagens, and elastin. (asm.org)
  • Three highly conserved outer membrane proteins from Haemophilus ducreyi strain 35000 were cloned, overexpressed, and purified from Escherichia coli for use as antigens in the rpEIA. (asm.org)
  • To circumvent this problem, we have expressed the genes encoding three outer membrane proteins of H. ducreyi strain 35000 and have purified the proteins to use them as antigens. (asm.org)
  • Immunodepletion of LspA proteins from H. ducreyi culture supernatant fluid abolished this inhibitory effect, indicating that the LspA proteins are necessary for the inhibition of phagocytosis by H. ducreyi. (elsevier.com)
  • Inhibition of phagocytosis by Haemophilus ducreyi requires expression of the LspA1 and LspA2 proteins. (medigraphic.com)
  • Next-generation sequencing enables whole-genome sequencing from clinical samples without prior culture, bypassing the culture requirements of H. ducreyi and enabling more detailed phylogenetic analysis. (cdc.gov)
  • Documentation must include clinical background leading to suspicion of H. ducreyi infection in a patient, including any additional factors that may increase the probability of H. ducreyi infection. (publichealthontario.ca)
  • Further surveys will be required to determine the epidemiology and clinical significance of this new and emerging manifestation of H. ducreyi infection. (antimicrobe.org)
  • Some of the characteristics of 42 clinical isolates of Haemophilus ducreyi are reported. (microbiologyresearch.org)
  • In the present article, we describe clinical outcomes for 267 volunteers who were infected with H. ducreyi. (elsevier.com)
  • The cyto-adherence kinetics of H. ducreyi to the epithelial cells was significantly greater at 33°C (10 times more) than at 37°C in all seven clinical isolates tested. (microbiologyresearch.org)
  • Clinical and in-situ cellular responses to Haemophilus ducreyi in the presence or absence of VIH infection. (medigraphic.com)
  • Southern blot analysis indicated that lspA1 and lspA2 sequences were present in 15 other geographically diverse H. ducreyi strains. (asm.org)
  • Fluorescence microscopy revealed that macrophages incubated with wild-type H. ducreyi, but not with a lspA1 lspA2 mutant, were unable to complete development of the phagocytic cup around immunoglobulin G-opsonized targets. (elsevier.com)
  • The genome of H. ducreyi is a single 1.7-Mb chromosome. (wikidoc.org)
  • Flowchart of whole-genome sequencing of Haemophilus ducreyi . (cdc.gov)
  • RT "The complete genome sequence of Haemophilus ducreyi. (genome.jp)
  • Identification was based on colony morphology and nutritional and biochemical properties of 120 fresh isolates of H. ducreyi. (microbiologyresearch.org)
  • Restriction enzyme analysis indicated that hlp was conserved among H. ducreyi isolates. (elsevier.com)
  • Characterization of Haemophilus parainfluenzae strains with low-Mr or ladder-like lipopolysaccharides. (aprel-reklama.ru)
  • Isolation of H. ducreyi in low-income settings is challenging, limiting phylogenetic investigation. (cdc.gov)
  • In addition, isolation of H. ducreyi from ulcer specimens is insensitive ( 21 ). (asm.org)
  • Such analysis has identified a class I genetically distinct subclade strain of H. ducreyi that may cause non-sexually transmitted (CLU). (wikidoc.org)
  • Of 100 GUD samples analysed from 43 HIV positive and 57 HIV negative individuals, 71% were positive for one or more sexually transmitted infection (STI) pathogens by real-time PCR (61% for HSV-2, 5% for T pallidum , 3% for HSV-1, 1% for H ducreyi and 1% for dual H ducreyi /HSV-2). (bmj.com)
  • We provide direct evidence that natural intoxication of cells with the Haemophilus ducreyi CDT (HdCDT) holotoxin induces DNA double-strand breaks similarly to ionizing radiation. (csuca.org)
  • Although monoclonal antibody 5C9 recognizes a species-specific epitope of a unique H. ducreyi lipoprotein, the presence of serum antibodies to Hlp may not indicate previous infection with H. ducreyi. (elsevier.com)
  • Acute bacterial exacerbations of chronic bronchitis due to Haemophilus influenzae or Streptococcus pneumoniae . (rxlist.com)
  • Community-acquired Pneumonia due to Haemophilus influenzae or Streptococcus pneumoniae . (rxlist.com)
  • A transposon insertion mutant of Haemophilus ducreyi 35000 possessing a truncated lipooligosaccharide (LOS) failed to hind the LOS-specific monoclonal antibody 3E6 (M. K. Stevens, L. D. Cope, J. D. Radolf and E. J. Hansen, Infect. (elsevier.com)
  • It appears to respond to standard antimicrobial therapy used to treat H. ducreyi ( 20 , 24 ). (antimicrobe.org)
  • Haemophilus ducreyi resists the cytotoxic effects of human antimicrobial peptides (APs), including α-defensins, β-defensins, and the cathelicidin LL-37. (iupui.edu)
  • Retrieved 30 June Antimicrobial susceptibility udcreyi Haemophilus ducreyi. (local-travel.info)
  • Haemophilus ducreyi is resistant to human antimicrobial peptides. (medigraphic.com)
  • We also examined the roles of two H. ducreyi surface structures, the fine tangled pili and lipooligosaccharide (LOS), in ECM adherence. (asm.org)
  • H. ducreyi grows best in microaerophilic conditions at 33-35°C in a humid atmosphere containing 5% CO 2 ( 9 ) . (canada.ca)
  • Haemophilus ducreyi is a small, gram-negative, non-spore-forming, non-motile, facultative anaerobic coccobacillus that grows best in a humid atmosphere containing 5% CO 2 , at temperatures of 33-35°C (microaerophilic conditions). (lecturio.com)
  • In experimental and natural infection, H. ducreyi is found in the hostile environment of an abscess and resists phagocytosis. (grantome.com)