The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
The valve between the left atrium and left ventricle of the heart.
Prosthesis, usually heart valve, composed of biological material and whose durability depends upon the stability of the material after pretreatment, rather than regeneration by host cell ingrowth. Durability is achieved 1, mechanically by the interposition of a cloth, usually polytetrafluoroethylene, between the host and the graft, and 2, chemically by stabilization of the tissue by intermolecular linking, usually with glutaraldehyde, after removal of antigenic components, or the use of reconstituted and restructured biopolymers.
A valve situated at the entrance to the pulmonary trunk from the right ventricle.
The valve consisting of three cusps situated between the right atrium and right ventricle of the heart.
The hollow, muscular organ that maintains the circulation of the blood.
Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.
Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA.
The plan and delineation of prostheses in general or a specific prosthesis.
Pathologic deposition of calcium salts in tissues.
Inflammation of the inner lining of the heart (ENDOCARDIUM), the continuous membrane lining the four chambers and HEART VALVES. It is often caused by microorganisms including bacteria, viruses, fungi, and rickettsiae. Left untreated, endocarditis can damage heart valves and become life-threatening.
Flaps within the VEINS that allow the blood to flow only in one direction. They are usually in the medium size veins that carry blood to the heart against gravity.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
The downward displacement of the cuspal or pointed end of the trileaflet AORTIC VALVE causing misalignment of the cusps. Severe valve distortion can cause leakage and allow the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to aortic regurgitation.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Elements of limited time intervals, contributing to particular results or situations.
A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annuli of HEART VALVES. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.
A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annulus of the MITRAL VALVE. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs.
Surgery performed on the heart.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
Pathological conditions involving the HEART including its structural and functional abnormalities.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.
An abnormal balloon- or sac-like dilatation in the wall of AORTA.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The pathologic narrowing of the orifice of the PULMONARY VALVE. This lesion restricts blood outflow from the RIGHT VENTRICLE to the PULMONARY ARTERY. When the trileaflet valve is fused into an imperforate membrane, the blockage is complete.
Graphic registration of the heart sounds picked up as vibrations and transformed by a piezoelectric crystal microphone into a varying electrical output according to the stresses imposed by the sound waves. The electrical output is amplified by a stethograph amplifier and recorded by a device incorporated into the electrocardiograph or by a multichannel recording machine.
Widening of a stenosed HEART VALVE by the insertion of a balloon CATHETER into the valve and inflation of the balloon.
Types of spiral computed tomography technology in which multiple slices of data are acquired simultaneously improving the resolution over single slice acquisition technology.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Agents that prevent clotting.
Methods of creating machines and devices.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)
Cardiac manifestation of systemic rheumatological conditions, such as RHEUMATIC FEVER. Rheumatic heart disease can involve any part the heart, most often the HEART VALVES and the ENDOCARDIUM.
The tendinous cords that connect each cusp of the two atrioventricular HEART VALVES to appropriate PAPILLARY MUSCLES in the HEART VENTRICLES, preventing the valves from reversing themselves when the ventricles contract.
The chambers of the heart, to which the BLOOD returns from the circulation.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
The behaviors of materials under force.
The transference of a heart from one human or animal to another.
The sounds heard over the cardiac region produced by the functioning of the heart. There are four distinct sounds: the first occurs at the beginning of SYSTOLE and is heard as a "lubb" sound; the second is produced by the closing of the AORTIC VALVE and PULMONARY VALVE and is heard as a "dupp" sound; the third is produced by vibrations of the ventricular walls when suddenly distended by the rush of blood from the HEART ATRIA; and the fourth is produced by atrial contraction and ventricular filling.
A fetal heart structure that is the bulging areas in the cardiac septum between the HEART ATRIA and the HEART VENTRICLES. During development, growth and fusion of endocardial cushions at midline forms the two atrioventricular canals, the sites for future TRICUSPID VALVE and BICUSPID VALVE.
Echocardiography amplified by the addition of depth to the conventional two-dimensional ECHOCARDIOGRAPHY visualizing only the length and width of the heart. Three-dimensional ultrasound imaging was first described in 1961 but its application to echocardiography did not take place until 1974. (Mayo Clin Proc 1993;68:221-40)
The coordination of a sensory or ideational (cognitive) process and a motor activity.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
The condition of an anatomical structure's being dilated beyond normal dimensions.
The detailed examination of observable activity or behavior associated with the execution or completion of a required function or unit of work.
A long, narrow, and flat bone commonly known as BREASTBONE occurring in the midsection of the anterior thoracic segment or chest region, which stabilizes the rib cage and serves as the point of origin for several muscles that move the arms, head, and neck.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).
The main trunk of the systemic arteries.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Techniques for securing together the edges of a wound, with loops of thread or similar materials (SUTURES).
The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
Contractile activity of the MYOCARDIUM.
Resistance and recovery from distortion of shape.
A benign tumor of fibrous or fully developed connective tissue.
System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
The process by which cells convert mechanical stimuli into a chemical response. It can occur in both cells specialized for sensing mechanical cues such as MECHANORECEPTORS, and in parenchymal cells whose primary function is not mechanosensory.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
The dilatation of the aortic wall behind each of the cusps of the aortic valve.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
The properties and processes of materials that affect their behavior under force.
The period following a surgical operation.
Bleeding or escape of blood from a vessel.
The fitting and adjusting of artificial parts of the body. (From Stedman's, 26th ed)
Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.
Downward displacement of any one of the HEART VALVES from its normal position. This usually results in failed valve closure.
Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.
Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.
The innermost layer of the heart, comprised of endothelial cells.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Formation and development of a thrombus or blood clot in the blood vessel.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The valve, at the junction of the CECUM with the COLON, that guards the opening where the ILEUM enters the LARGE INTESTINE.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Restoration of an organ or other structure to its original site.
Pathological processes involving any part of the AORTA.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
The haemodynamic performance in both mitral and aortic positions was superior to all known artificial heart valves and that the ... At around that time a series of severe problems were encountered with the mechanical Bjork-Shiley valve. Some 10 years after ... Ionescu M I, Holden M D, Petrila P A "Fascia Lata Heart Valves; with section on Free Fascia Lata Grafts for Aortic Valve ... Biological Tissue in Heart Valve Replacement, Butterworths, (1972), London, pages 467-513. Ionescu M I, Ross D N, "Heart Valve ...
The results showed that this original valve exhibited the best haemodynamic performance, at rest and during exercise, when ... For the new generation valves, the ratio was about 5:1 in favour of the aortic valve. The much smaller number of mitral valve ... Both mechanical prosthetic devices and tissue heart valves are affected. The incidence of endocarditis, in western countries, ... 1965 Binet and associates in Paris, France, began the use of porcine aortic valves for aortic valve replacement in humans. 1967 ...
Decellularized aortic homografts (DAH) for aortic valve replacement and decellularized pulmonary valves (DPH) for pulmonary ... Haemodynamic performance in terms of effective orifice area of DAH was outstanding compared to all other options and no ... tissue-engineered heart valves: technical considerations and implications for translational cell-based heart valve concepts. ... One option is replacement using a mechanical valve. This, however, necessitates a strict lifelong anticoagulation regime to ...
In general, mitral valve surgery requires "open-heart" surgery in which the heart is arrested and the patient is placed on a ... Mitral valve repair is preferred to mitral valve replacement where a repair is feasible as bioprosthetic replacement valves ... This method assumes that the aortic valve does not suffer from aortic insufficiency.[citation needed] Another way to quantify ... In acute MR secondary to a mechanical defect in the heart (i.e., rupture of a papillary muscle or chordae tendineae), the ...
Tissue engineered heart valves offer certain advantages over traditional biological and mechanical valves: Living valve - The ... One animal trial combined the transcatheter aortic valve replacement (TAVR) procedure with tissue engineered heart valves ( ... "Hemodynamic characteristics of the Matrix P decellularized xenograft for pulmonary valve replacement during the Ross operation ... and immunogenicity must all be carefully considered as they are key factors in the performance of the final product. Structural ...
When this pressure falls below the atrial pressure, atrio-ventricular valves open (mitral valve at left side and tricuspid ... Imaged volumetric definition of systolic heart performance is commonly accepted as ejection fraction. Volumetric definition of ... If diastolic dysfunction describes an abnormal mechanical property, diastolic heart failure describes a clinical syndrome. ... Aortic stenosis of any cause where the ventricular muscle becomes hypertrophied, and thence stiff, as a result of the increased ...
When this pressure falls below the atrial pressure, atrio-ventricular valves open (mitral valve at left side and tricuspid ... If diastolic dysfunction describes an abnormal mechanical property, diastolic heart failure describes a clinical syndrome. ... Imaged volumetric definition of systolic heart performance is commonly accepted as ejection fraction. Volumetric definition of ... Other causes of left ventricular stiffening include:[citation needed] Aortic stenosis of any cause where the ventricular muscle ...
... and mechanical (Ultracor). We also compared them with normal aortic valves and stenosed valves of variable severity. ... Heart 2012; 99 3-4 Published Online First: 19 Oct 2012. doi: 10.1136/heartjnl-2012-303028 ... Differences in performance of five types of aortic valve prostheses: haemodynamic assessment by dobutamine stress ... Differences in performance of five types of aortic valve prostheses: haemodynamic assessment by dobutamine stress ...
... repair and products used to treat issues associated with structural heart disease. ... Comparison of the hemodynamic and thrombogenic performance of two bileaflet mechanical heart valves using a CFD/FSI model. J ... The Medtronic Open Pivot™ Aortic Valved Graft (AVG) unites the proven performance of the Open Pivot Heart Valve with leading ... Valve Replacement with Mechanical Valves. Medtronic Open Pivot™ mechanical heart valves bring something fundamentally different ...
... secreted by valvular cells forms a scaffold that lends the heart valve the exact mechanical and tensile strength needed for ... accurate hemodynamic performance. ECM proteins are a key component of valvular endothelial cell (VEC)-valvular interstitial ... a scaffold that lends the heart valve the exact mechanical and tensile strength needed for accurate hemodynamic performance. ... communication essential for maintenance of the valve structure. This study reports the healthy adult pulmonary and aortic valve ...
The replacement aortic heart leaflets of the present invention include first and second segments. The second segment is ... Replacement aortic heart leaflets and method of making the same. ... heart valves. Some of the available mechanical valves tend to ... but often do not exhibit hemodynamic properties that approach the advantageous hemodynamic performance of a native valve. Thus ... The aortic valve, along with the pulmonary valve, has three cusps.. Heart valves, including the aortic valve, can exhibit ...
"Review of numerical methods for simulation of mechanical heart valves and the potential for blood clotting, Medical & ... Tilting disc versus bileaflet aortic valve substitutes: intraoperative and postoperative hemodynamic performance in humans ... Comparison of the hemodynamic and thrombogenic performance of two bileaflet mechanical heart valves using a CFD/FSI model ... Hemodynamic performance and thrombogenic properties of a superhydrophobic bileaflet mechanical heart valve ...
16470145 - The real impact of randomized clinical trials in heart valve surgery.. 18928495 - Hemodynamic performance of ... 25145635 - Does perfusion pattern influence stress-induced changes in left ventricular mechanical .... 1834805 - Aspirin and ... 3870555 - Re-operation for aortic and mitral prosthetic dysfunctions.. ... stentless versus stented valves: a systematic review and met.... ...
"Characterization of Hemodynamic Forces Induced by Mechanical Heart Valves: Reynolds Vs. Viscous Stresses," Ann. Biomed. Eng., ... In this paper, performance of aortic heart valve prosthesis in different geometries of the aortic root is investigated ... Computational Evaluation of the Haemodynamic Performance of a Novel Prosthetic Heart Valve ... These categories correspond to aortic valve stenosis and aortic valve insufficiency. The control case that corresponds to the ...
Early and Mid-Term Functional and Hemodynamic Evaluation of the St. Jude Medical Regent 17 mm Aortic Valve Mechanical ... The Journal of Heart Valve Disease, Contents, 2014, Volume 23 Number 1 January 2014, DEVICE EVALUATION, ... Early Hemodynamic Performance of the BioValsalva Valved Conduit after Aortic Root Replacement ... as an alternative to other valves, or to other surgical strategies such as annulus enlargement. ...
The haemodynamic performance in both mitral and aortic positions was superior to all known artificial heart valves and that the ... At around that time a series of severe problems were encountered with the mechanical Bjork-Shiley valve. Some 10 years after ... Ionescu M I, Holden M D, Petrila P A "Fascia Lata Heart Valves; with section on Free Fascia Lata Grafts for Aortic Valve ... Biological Tissue in Heart Valve Replacement, Butterworths, (1972), London, pages 467-513. Ionescu M I, Ross D N, "Heart Valve ...
The side edges of adjacent leaflets are sewn together so as to form a substantially tubular valve structure having an in-flow ... of the leaflets is adapted to flex inwardly into and out of engagement with another leaflet so as to close and open the valve ... A prosthetic heart valve has leaflets made of a thin and flexible material. ... Artificial Mechanical Valves * [0027] The hemodynamic performance of mechanical heart valves has been satisfactory but not ...
Hemodynamic performance of the Medtronic ADVANTAGE prosthetic heart valve in the aortic position: echocardiographic evaluation ... as a parameter for optimum orientation of mechanical aortic valves. Thorac Cardiovasc Surg2000;48:360-3. ... morbidity and mortality after aortic valve replacement with a bioprosthetic heart valve. J Heart Valve Dis1998;7:211-18. ... VP-PM, valve prosthesis-patient mismatch. The clinical impact of valve prosthesis-patient mismatch (VP-PM)1 after aortic valve ...
Professional information about heart valve replacement and products used to treat issues associated with structural heart ... Comparison of the hemodynamic and thrombogenic performance of two bileaflet mechanical heart valves using a CFD/FSI model. J ... The Medtronic Open Pivot™ Aortic Valved Graft (AVG) unites the proven performance of the Medtronic Open Pivot Heart valve with ... VALVE REPLACEMENT WITH MECHANICAL VALVES. Medtronic Open Pivot™ mechanical heart valves bring something fundamentally different ...
The results showed that this original valve exhibited the best haemodynamic performance, at rest and during exercise, when ... For the new generation valves, the ratio was about 5:1 in favour of the aortic valve. The much smaller number of mitral valve ... Both mechanical prosthetic devices and tissue heart valves are affected. The incidence of endocarditis, in western countries, ... 1965 Binet and associates in Paris, France, began the use of porcine aortic valves for aortic valve replacement in humans. 1967 ...
In vitro testing has documented the potential for impaired hemodynamic performance and reduced durability with asymmetrical, ... Some of these issues might be addressed by new delivery systems and transcatheter heart valves (THV). We report early ... Specific device-related and procedure-related factors might determine the likelihood of mechanical injury to the ... transcatheter aortic valve replacement. TEE. transesophageal echocardiography. THV. transcatheter heart valve. TTE. ...
As a consequence, hemodynamic performance of bileaflet valvular prostheses can be severely reduced. The early detection of ... formation which usually deposit on bileaflet mechanical heart valves progressively lead to incomplete opening of the valve. At ... Data were acquired during simulations in the aortic position with the Sheffield Pulse Duplicator. Different hydrodynamic ... formation which usually deposit on bileaflet mechanical heart valves progressively lead to incomplete opening of the valve. At ...
Aortic and Mitral Valve Replacement with the Carpentier-Edwards Pericardial Bioprosthesis: 10-year Results. J Heart Valve Dis. ... The Carpentier-Edwards Perimount Magna aortic xenograft: a new design with an improved hemodynamic performance. Interactive ... Aortic Valve Replacement with Mechanical and Biologic Prosthesis in Middle-aged Patients. Ann Thorac Surg. 2001;71:S253-256. ( ... Pericardial Valves in Small Aortic Annuli: Ten Years Results. Eur J Cardiothorac Surg. 1996;10(10):879-883. (Cohort size = 90 ...
Carpentier-Edwards PERIMOUNT aortic heart valve. The Carpentier-Edwards PERIMOUNT aortic valve is the first biomechanically ... The Carpentier-Edwards Perimount Magna aortic xenograft: a new design with an improved hemodynamic performance. Interactive ... Aortic Valve Replacement with Mechanical and Biologic Prosthesis in Middle-aged Patients. Ann Thorac Surg. 2001;71:S253-256. ( ... Carpentier-Edwards PERIMOUNT RSR aortic heart valve. The Carpentier-Edwards PERIMOUNT RSR aortic valve combines a proven design ...
The company recently presented favorable study outcomes on its bioprosthetic surgical aortic valves featuring the Resilia ... aortic valves featuring its novel Resilia tissue platform continued to demonstrate favorable safety and hemodynamic performance ... The study is designed to evaluate the safety and effectiveness of surgical aortic heart valves with Resilia tissue in this ... and highlights the potential of valves containing Resilia tissue for patients who may otherwise opt for a mechanical valve, ...
Commissural Alignment in Transcatheter and Surgical Heart Valves. On the basis of pre- and post-aortic valve replacement ... 1998) The hemodynamic effects of mechanical prosthetic valve type and orientation on fluid mechanical energy loss and pressure ... the impact of the positioning strategy on valve performance. J Biomech 49:2513-2519. ... surgical aortic valve replacement. SHV. surgical heart valve. TAVR. transcatheter aortic valve replacement. THV. transcatheter ...
13) recently published a study examining the hemodynamic performance of Cribier-Edwards and Edwards SAPIEN valves. TAVI ... mechanical versus stentless biological valves. Heart 91:1023-1029. ... transcatheter aortic valve implantation. Aortic valve replacement (AVR) in patients with severe aortic stenosis (AS) and a ... 1999) Hemodynamic and physical performance during maximal exercise in patients with an aortic bioprosthetic valve: comparison ...
Types of Valves. Prosthetic heart valves have had a history of almost 60 years. Starr-Edwards ball mechanical heart valves have ... hemodynamic performance than the ball valve, but are prone to disastrous thrombosis in case of valve fracture and are less ... valves in aortic valve replacement. This study included 32 articles (15 on mechanical valves and 23 on bioprosthetic valves), a ... The Edinburgh heart valve study reported a survival advantage of mechanical valves over 12 years, but after 20 years there was ...
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots, Rodent Working Heart ... Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension, Echocardiographic Assessment of the Right ... Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves, Assessment of Right Ventricular Structure and ... Model for the Study of Myocardial Performance and Oxygen Consumption, ...
Valve sizes were 19 mm (6), 21 mm (33), 23 mm (41), 25 mm (30). Two patients receiving size 27 valves were excluded from the ... centers were studied between January 2003 and February 2005 to obtain non-invasive data regarding the hemodynamic performance ... During DSE testing, the following statistically significant changes took place: Heart rate increased by 73.0%, cardiac output ... The changes in pressure gradients add to the hemodynamic characteristics of the various valve sizes. In our patients the St. ...
... and potentially improved valve performance.METHODS: Using 3D printing, a left heart simulator with a valve-sparing root ... Aortic valves were dissected from fresh porcine hearts and reimplanted into either straight tubular grafts (n=6) or Valsalva ... Conduits were mounted into the heart simulator and hemodynamic, echocardiographic, and high-speed videometric data were ... We also observed a higher rate-while not statistically significant-of preoperative and postoperative use of mechanical ...
... in bioprosthetic valve technology have greatly enhanced the haemodynamic performance and long-term durability of tissue valves ... Acute Structural Failure of the Trifecta Aortic Valve Bioprosthesis. Zhu MZL, Newman MA, Joshi P, Passage J Heart Lung Circ ... Plasma mediated protein immobilisation enhances the vascular compatibility of polyurethane with tissue matched mechanical ... Heart Valve Surgery Performed by Trainee Surgeons: Meta-Analysis of Clinical Outcomes. Saxena A, Virk SA, Bowman SRA, Jeremy R ...
Bicuspid aortic valve (BAV) is the most common type of congenital heart disease, occurring in 0.5-2% of the population, where ... angle in BAV type-1 configuration on the valves structural and hemodynamic performance. Toward that goal, a parametric fluid- ... Rotary blood pumps (RBPs) used for mechanical circulatory support of heart failure patients cannot passively change pump flow ... Fluid-Structure Interaction Models of Bicuspid Aortic Valves: The Effects of Nonfused Cusp Angles ...
Haemodynamic Performance and Weaning from Mechanical Ventilation Following Open-Heart Surgery, European Journal of Intensive ... F Mitral Valve Replacement Dopamine Lidocaine Cephapirim 70 M Aortic Commissuortomy Mitral Valve Replacement 69 M Aortic Valve ... Components of the CV system Heart anatomy Layers of the heart wall Pericardium Heart chambers, valves, blood vessels, septum ... Section 5.1 The heart and heart disease Section 5.1 The heart and heart disease Mammals are too large to rely on diffusion. ...
... and potentially improved valve performance.METHODS: Using 3D printing, a left heart simulator with a valve-sparing root ... Aortic valves were dissected from fresh porcine hearts and reimplanted into either straight tubular grafts (n=6) or Valsalva ... Conduits were mounted into the heart simulator and hemodynamic, echocardiographic, and high-speed videometric data were ... We also observed a higher rate-while not statistically significant-of preoperative and postoperative use of mechanical ...
Evaluated were NYHA class, transvalvular gradients, estimated aortic valve orifice area, degree of aortic valve insufficiency, ... Porcine stentless aortic valves provide excellent hemodynamic long-term results without significant rise of transvalvular ... Hemodynamic long-term behavior and the adaptation of the left ventricle as well as valve-durability in patients aged ≤60 years ... 7 to 16 years after aortic valve replacement, 54 patients (mean age at operation 53.1 ± years) received echocardiography and ...
Aortic regurgitation (AR), also known as aortic insufficiency (AI), is the leaking of the aortic valve of the heart that causes ... All forms of AR produce a similar hemodynamic abnormality. The inability of the aortic valve leaflets to remain closed or ... heart disease concluded that beta blocker therapy was reasonable in patients with bicuspid aortic valves who have an aortic ... Atypical chest pain induced by a mechanical interaction between the heart and the chest wall. ...
  • These categories correspond to aortic valve stenosis and aortic valve insufficiency. (asme.org)
  • mean age 69.2 ± 7.3 years) with aortic valve stenosis underwent first-time aortic valve replacement (AVR) with the SJMR-17. (icr-heart.com)
  • Methods The CENTERA valve (Edwards Lifesciences, Irvine, California) was implanted in 15 patients with symptomatic severe aortic stenosis via femoral or axillary arterial percutaneous access. (onlinejacc.org)
  • The TAVR with the CENTERA THV was performed in 15 patients with symptomatic, severe aortic stenosis at 2 centers (St. Paul's Hospital, Vancouver, Canada, and the Asklepios Klinik St. Georg, Hamburg, Germany) between 2010 and 2012. (onlinejacc.org)
  • Transcatheter aortic valve replacement (TAVR) has become an established therapeutic option for patients with symptomatic, severe aortic valve stenosis (AS) who are ineligible or at high risk for surgical aortic valve replacement (SAVR) (1-3) . (onlinejacc.org)
  • Background The presence of a small aortic annulus may complicate the surgical management of patients with severe aortic stenosis (AS). (onlinejacc.org)
  • Aortic valve replacement (AVR) in patients with severe aortic stenosis (AS) and a small aortic annulus has been associated with a high incidence of prosthesis-patient mismatch (PPM) ( 1-3 ). (onlinejacc.org)
  • Transcatheter aortic valve implantation (TAVI) has emerged as an alternative to AVR in high-risk patients with AS ( 10-12 ), and implanted prostheses perform well compared with currently available surgical valves with respect to relief of aortic stenosis and post-procedural valve hemodynamics ( 13 ). (onlinejacc.org)
  • Studies have found that more than one in eight people over 75 years of age have moderate or severe aortic stenosis [ 3 ] , awaiting surgical correction, not counting asymptomatic patients, often younger in age. (bjcvs.org)
  • Aortic stenosis in the young is often easily overlooked compared to the elderly. (bjcvs.org)
  • This review will investigate aortic stenosis interventions with focus on the options available to the younger populations and developments in related modalities, provide evidence in support of these treatments, and highlight a few unanswered questions in related fields. (bjcvs.org)
  • Aortic stenosis in younger patients is often a result of bicuspid aortic valve (BAV) [ 6 ] , although rheumatic heart disease is also possible. (bjcvs.org)
  • 46 woman and 66 men, aged 61.8 ± 9.7 (18-75) years, were operated on for aortic regurgitation (17), stenosis (65), or mixed dysfunction (30). (biomedcentral.com)
  • The current increase in life expectancy implies increasing need for small and medium size valve replacement since the augmented number of aortic stenosis in the elderly is frequently accompanied by a narrow aortic root. (biomedcentral.com)
  • A total of 112 patients (46 women and 66 male) undergoing surgery for aortic stenosis (n = 65), aortic regurgitation (n = 17) or both (n = 30) between January 2003 and February 2005 at seven Scandinavian centers were included in the study. (biomedcentral.com)
  • In the disease calcific aortic stenosis (CAS), calcified nodules progressively stiffen the cusps. (biomedsearch.com)
  • Dhoble A, Sarano ME, Kopecky SL, et al: Safety of symptom-limited cardiopulmonary exercise testing in patients with aortic stenosis. (wjcmpr.com)
  • Lin SS, Roger VL, Pascoe R, et al: Dobutamine stress Doppler hemodynamics in patients with aortic stenosis: feasibility, safety, and surgical correlations. (wjcmpr.com)
  • Van Le D, Jensen GV, Carstensen S, et al: Cardiopulmonary exercise testing in patients with asymptomatic or equivocal symptomatic aortic stenosis: feasibility, reproducibility, safety and information obtained on exercise physiology. (wjcmpr.com)
  • Percutaneous valvular replacement in aortic stenosis is an emerging alternative therapy for high-risk patients. (invasivecardiology.com)
  • Degenerative aortic valve stenosis (AVS) is the most common valvular heart disease in the elderly. (invasivecardiology.com)
  • Surgical aortic valve replacement is the most common procedure of choice for the treatment of severe aortic stenosis. (springer.com)
  • Aortic stenosis (AS) is the most common valvular heart disease in industrialized countries, and its impact on public health is expected to increase due to the aging population. (springer.com)
  • Discrete subaortic stenosis (DSS) is a congenital heart disease that results in the formation of a fibro-membranous tissue, causing an increased pressure gradient in the left ventricular outflow tract (LVOT). (frontiersin.org)
  • Discrete subaortic stenosis (DSS) is a congenital heart disease characterized by the formation of a fibrous membrane obstructing the left ventricular outflow tract (LVOT). (frontiersin.org)
  • Although most bicuspid aortic valve (BAV) patients will suffer from some complications including aortic stenosis, aortic regurgitation, endocarditis, and heart dysfunction in the late stage of the disease, there is none symptom in the childhood, which restrains us to diagnose and treatment in the onset phase of BAV. (frontiersin.org)
  • In 1972, she was diagnosed with mitral valve insufficiency and mitral valve stenosis, then in 1974, a decision was made to perform mitral valve replacement surgery with a 32-mm Braunwald-Cutter ball cage prosthesis. (deepdyve.com)
  • with mitral valve insufficiency and mitral valve stenosis though Firstable the valve was developed for mitral valve replacement her symptoms improved with medical therapy. (deepdyve.com)
  • Transcatheter heart valve implantation may be a viable alternative to surgical aortic valve replacement for high-risk patients with native aortic stenosis, and valve-in-valve (V-in-V) implantation has been successfully performed for failed surgical bioprostheses in the aortic, mitral, pulmonic, and tricuspid positions. (onlinejacc.org)
  • Transcatheter aortic valve replacement for native aortic stenosis has evolved as a viable alternative to open heart surgery in patients with high or prohibitive surgical risk ( 13-20 ). (onlinejacc.org)
  • Since heart valves are passive structures that simply open and close in response to differential pressures on either side of the particular valve, the problems that can develop with valves can be classified into two categories: (1) stenosis, in which a valve does not open properly, and (2) insufficiency (also called regurgitation), in which a valve does not close properly. (justia.com)
  • Stenosis and insufficiency may occur concomitantly in the same valve or in different valves. (justia.com)
  • Long-term Surgical Prognosis of Primary Supravalvular Aortic Stenosis Repair. (childrenshospital.org)
  • Transcatheter approaches for management of aortic stenosis (AS) have revolutionized the treatment of AS in several patient populations. (annalscts.com)
  • A 14-year-old boy after balloon valvuloplasty of severe aortic valve stenosis in the neonatal period was referred for heart-lung transplantation because of high grade pulmonary hypertension and left heart dysfunction due to endocardial fibroelastosis with severe mitral insufficiency. (hindawi.com)
  • On echocardiography at that time severe mitral valve regurgitation and a markedly enlarged left atrium were seen besides the well-known mild aortic valve stenosis/regurgitation and endocardial fibroelastosis. (hindawi.com)
  • Severe calcific aortic stenosis is relatively common, and unless treated with valve replacement it carries an adverse prognosis. (bmj.com)
  • Transcatheter aortic valve implantation (TAVI), a technique in which a bioprosthetic valve is inserted via a catheter and implanted within the diseased native aortic valve, is a new therapeutic modality for treatment of older patients with severe symptomatic aortic stenosis and other comorbidities, who have an inherently high surgical risk. (bmj.com)
  • The initial success rates have led to a rapid adoption of this technique in clinical practice in high-risk patients with severe symptomatic aortic stenosis. (bmj.com)
  • Severe symptomatic aortic stenosis carries a poor prognosis. (medscape.com)
  • Until relatively recently, surgical aortic valve replacement has been the standard of care in adults with severe symptomatic aortic stenosis . (medscape.com)
  • Indicated for patients at intermediate or greater risk for open heart surgery, TAVR may be an excellent option for certain patients because the prevalence of aortic stenosis and comorbidities may increase the risks associated with surgical aortic valve replacement (SAVR). (medscape.com)
  • A heart team comprising cardiac surgeons, interventional cardiologists, and other aortic stenosis experts may determine what the best procedure is as well as take into account other considerations such as whether the patient should receive a mild sedative or general anesthesia. (medscape.com)
  • See related handout on aortic stenosis , written by the authors of this article. (aafp.org)
  • Aortic stenosis affects 3% of persons older than 65 years. (aafp.org)
  • During the asymptomatic latent period, left ventricular hypertrophy and atrial augmentation of preload compensate for the increase in after-load caused by aortic stenosis. (aafp.org)
  • Aortic valve replacement is recommended for most symptomatic patients with evidence of significant aortic stenosis on echocardiography. (aafp.org)
  • In asymptomatic patients, serial Doppler echocardiography is recommended every six to 12 months for severe aortic stenosis, every one to two years for moderate disease, and every three to five years for mild disease. (aafp.org)
  • Cardiology referral is recommended for all patients with symptomatic moderate and severe aortic stenosis, those with severe aortic stenosis without apparent symptoms, and those with left ventricular systolic dysfunction. (aafp.org)
  • Aortic valve stenosis affects 3% of persons older than 65 years and is the most significant cardiac valve disease in developed countries. (aafp.org)
  • 2 The development of significant aortic stenosis tends to occur earlier in persons with congenital bicuspid aortic valves and in those with disorders of calcium metabolism, such as in renal failure. (aafp.org)
  • In patients with aortic stenosis, the 10-year cardiovascular risk should be determined and the benefits and risks of statin therapy and aspirin prophylaxis should be discussed based on current guidelines. (aafp.org)
  • Transthoracic echocardiography is indicated when there is a loud unexplained systolic murmur, a single second heart sound, a history of a bicuspid aortic valve, or symptoms that might be caused by aortic stenosis. (aafp.org)
  • Aortic valve replacement is the only treatment that improves mortality in patients with symptomatic severe aortic stenosis. (aafp.org)
  • Watchful waiting is recommended for most patients with asymptomatic aortic stenosis. (aafp.org)
  • Antimicrobial prophylaxis for bacterial endocarditis is not recommended for patients with aortic stenosis unless they have undergone aortic valve replacement or have a history of endocarditis. (aafp.org)
  • aortic stenosis 3. (cueflash.com)
  • Surgical aortic valve replacement (SAVR) is the only treatment known to improve symptoms and survival in patients with severe, symptomatic aortic stenosis. (annals.org)
  • This review describes the available literature on PHVR for aortic stenosis, which comprised 84 published reports representing 76 distinct studies and 2375 unique patients. (annals.org)
  • Surgical aortic valve replacement is the only proven effective treatment of aortic stenosis. (annals.org)
  • Successful implantation and 30-day survival rates for PHVR for aortic stenosis in a recent series were approximately 97% and 92%, respectively. (annals.org)
  • Aortic stenosis is one of the most common valvular disorders in older adults, with a prevalence of approximately 8% at age 85 (1) . (annals.org)
  • The typical symptoms of aortic stenosis include angina, syncope, and heart failure. (annals.org)
  • In adults with severe, symptomatic aortic stenosis, 2-year mortality is approximately 50% (2) , and open surgical aortic valve replacement (SAVR) is the only treatment that has been shown to improve symptoms, functional status, and survival (3) . (annals.org)
  • Native valve emergencies are almost always the result of regurgitation, while acute prosthetic valve dysfunction may be the result of either regurgitation or stenosis. (emdocs.net)
  • We have entered a new era in understanding degenerative aortic stenosis in elderly patients. (jaoa.org)
  • With the aging of the US population and the progressive decrease in coronary heart disease prevalence in the past 50 years, aortic stenosis has become a major cardiac concern. (jaoa.org)
  • A new classification of aortic stenosis recognizes 4 categories based on flow state (normal or low) and valve gradient (high or low). (jaoa.org)
  • Aortic stenosis (AS) is the most common cardiac valve disease in the United States. (jaoa.org)
  • We are in a new era in which the timing of a surgical procedure is determined not just by the patient's symptoms, but also by the severity of the valve narrowing and the response of the left ventricle to valve stenosis. (jaoa.org)
  • The response of the left ventricle is key to understanding the progression to severe, symptomatic aortic stenosis. (jaoa.org)
  • Paravalvular aortic regurgitation at 30-day follow-up was none/trivial in 3 (23%), mild in 9 (69%), and moderate in 1 (8%) patient. (onlinejacc.org)
  • The degree of commissural alignment was not associated with a difference in transvalvular gradient, paravalvular aortic regurgitation, or simulated coronary filling. (onlinejacc.org)
  • however, there is a significantly higher rate of mild central aortic regurgitation in case of moderate or greater CMA. (onlinejacc.org)
  • Only 5 patients showed relevant regurgitation (at 13-16 years after valve replacement), 49 showed no or trivial regurgitation. (biomedcentral.com)
  • Aortic regurgitation (AR), also known as aortic insufficiency (AI), is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during diastole, from the aorta into the left ventricle. (renalandurologynews.com)
  • Valve replacement surgery has a long and important history, with initial efforts aimed to deal with aortic valve regurgitation by implantation of valves in the descending aorta. (ahajournals.org)
  • These devices are approved for treatment of severe AVS, but percutaneous valve replacement to treat severe regurgitation of a biological prosthesis has been described. (invasivecardiology.com)
  • Physical examination revealed a diastolic murmur due to aortic regurgitation, pulmonary rales and high blood pressure (170/90 mmHg). (invasivecardiology.com)
  • Transthoracic echocardiography (TTE) revealed severe aortic regurgitation with a mean transvalvular gradient of 28 mmHg and an enlarged left ventricle with preserved systolic left ventricular function (left ventricular ejection fraction 56%) (Table 1). (invasivecardiology.com)
  • Coronary angiography showed a 70% of the left anterior descending (LAD) artery, confirmed severe aortic regurgitation (Figure 1), and both the iliac and femoral arteries were found to have a diameter of 9 mm and 8 mm, respectively. (invasivecardiology.com)
  • Tricuspid valve regurgitation was demonstrated with a maximum velocity of 5.28 m/sec presuming a systolic pulmonary artery pressure of 111 mmHg (Figure 1 ). (hindawi.com)
  • A novel 3D-Printed preferential posterior mitral annular dilation device delineates regurgitation onset threshold in an ex vivo heart simulator , Annabel M. Imbrie-Moore, Cole C. Paullin, Michael J. Paulsen, Frederick Grady, Hanjay Wang, Camille E. Hironaka, Justin M. Farry, Haley J. Lucian. (vivitrolabs.com)
  • With the declining incidence of rheumatic fever the importance of pure aortic regurgitation has increased steadily. (aerzteblatt.de)
  • L, a 4/6 diastolic murmur consistent with his known history of aortic regurgitation, and JVD without peripheral edema. (emdocs.net)
  • 8 In acute aortic regurgitation (AR), the left ventricle (LV) pathologically fills during ventricular diastole preventing forward flow from the left atrium (LA). This greatly reduces stroke volume and causes a compensatory tachycardia to maintain cardiac output. (emdocs.net)
  • Further, Abbott plans to grow the mitral offering with its Tendyne* and COAPT trials , which would expand the market for transcatheter mitral valve replacement and offer a functional mitral regurgitation repair treatment, respectively. (abbott.com)
  • Take the MitraClip System, a first-of-its-kind technology for the minimally invasive repair of mitral regurgitation (MR), one of the most common heart valve conditions affecting one in ten people over the age of 75. (abbott.com)
  • Hemodynamic consequence of afterload reduction in patients with chronic aortic regurgitation. (who.int)
  • The natural history of asymptomatic patients with chronic aortic regurgitation : serial long-term changes in left ventricular function. (who.int)
  • Asymptomatic aortic regurgitation : indication for operation. (who.int)
  • Progress in mitral and aortic regurgitation. (who.int)
  • Beneficial long term effects of hydralazine in aortic regurgitation. (who.int)
  • Vasodilator therapy for chronic aortic and mitral regurgitation. (who.int)
  • Current techniques and strategies for correction of cardiac anomalies of the RVOT include surgical repair and/or replacement of the pulmonary valve. (medtronic.com)
  • Experiments were performed at test conditions corresponding to 70 beats/min, 5.5 L/min target cardiac output, and a mean aortic pressure of 100 mmHg. (asme.org)
  • This was followed by the creation of the Dacron covered titanium frame for mounting the porcine aortic valves to be able to implant them in all three cardiac locations (mitral, aortic, tricuspid). (wikipedia.org)
  • The experimental and in vitro testing of this novel device took place in 1970, and in March 1971, Ionescu began, for the first time, the implantation of the pericardial valve in all three cardiac positions in humans. (wikipedia.org)
  • During DSE testing, the following statistically significant changes took place: Heart rate increased by 73.0%, cardiac output by 85.5%, left ventriclular ejection fraction by 19.6%, and maximal mean prosthetic transvalvular gradient by 133.8%, whereas the effective orifice area index did not change. (biomedcentral.com)
  • Haemodynamic performance of heart valve prosthesis can be defined as its ability to fully open and completely close during the cardiac cycle, neither overloading heart work nor damaging blood particles when passing through the valve. (biomedcentral.com)
  • Right-heart catheterization showed moderate pulmonary hypertension (pulmonary artery systolic pressure [PAPs]/d/m 75/20/35 mmHg, pulmonary capillary wedge pressure [PWCP] 18 mmHg), with low cardiac output measured with the Fick method (CO 2.6 L/minute). (invasivecardiology.com)
  • The results showed how the performance of cardiac valve substitutes is negatively affected by the presence of pledget-armed sutures. (springer.com)
  • An extracardiac pumping for supplementing the circulation of blood, including the cardiac output, in a patient without any component thereof being connected to the patient's heart, and methods of using same. (google.ca)
  • Field ofthe Invention The invention herein described relates to cardiac atrioventricular valves and minimally invasive delivery systems thereof. (google.com)
  • Hemodynamic abnormalities induced by the malformations of the valves in BAV patients for a long time will cause BAV-associated aortopathy: including progress aortic dilation, aneurysm, dissection and rupture, cardiac cyst and even sudden death. (frontiersin.org)
  • When bioprosthetic cardiac valves fail, reoperative valve replacement carries a higher risk of morbidity and mortality compared with initial valve replacement. (onlinejacc.org)
  • Despite the shorter durability of bioprosthetic cardiac valves compared with mechanical prostheses, the former are often used to reduce thromboembolic risk and to avoid anticoagulation and the associated increased risk of bleeding ( 1,2 ). (onlinejacc.org)
  • Heart valve replacement surgeries account for 20% of all cardiac procedures. (redorbit.com)
  • Heart valve replacement surgeries account for 20% of all cardiac procedures and as the proportion of elderly in the United States increases, the number of valve replacements is expected to rise.1 Heart valve replacements also account for 30% of all deaths following cardiac surgeries l with in-hospital mortality rates around 4.3% for first-time isolated aortic valve replacements 2 and 10% for mitral valve replacements and surgeries. (redorbit.com)
  • Bicuspid Aortic Valves (BAV) is the most common congenital cardiac defect occurring in approximately 1-2% of the newborn population in the USA. (gatech.edu)
  • 3 , 4 It is an important cause of congestive and sometimes intractable heart failure and of sudden cardiac death. (bmj.com)
  • Recent research [ 4 ] notes that the flow dynamics found in the LV reveal important information about overall cardiac health, useful in early diagnosis of patients with potential heart problems. (biomedcentral.com)
  • You can find videos of velocity distributions in valve leaflet opening and closing phases during one cardiac cycle on my LinkedIn profile ( https://www.linkedin.com/feed/update/urn:li:activity:6378579201003442176 , and https://www.linkedin.com/feed/update/urn:li:activity:6394588650172223488 ). (siemens.com)
  • The type of aortic prosthesis did not influence overall mortality, cardiac mortality, or major adverse valve-related events. (kjtcvs.org)
  • This study included patients who underwent aortic valve replacement as their first cardiac operation in their 60s, between the dates of January 1995 to December 2011. (kjtcvs.org)
  • The exclusion criteria were a Bentall operation, other concomitant cardiac valve replacement, aortic valve replacement for infective endocarditis, and acute coronary syndrome. (kjtcvs.org)
  • During this phase of the cardiac cycle, the mitral valve opens allowing flow from the left atrium to the left ventricle. (emdocs.net)
  • Heart failure develops when the heart, via an abnormality of cardiac function (detectable or not), fails to pump blood at a rate commensurate with the requirements of the metabolizing tissues or is able to do so only with an elevated diastolic filling pressure. (medscape.com)
  • This chest radiograph shows an enlarged cardiac silhouette and edema at the lung bases, signs of acute heart failure. (medscape.com)
  • Heart failure (see the images below) may be caused by myocardial failure but may also occur in the presence of near-normal cardiac function under conditions of high demand. (medscape.com)
  • Since mechanical valves are made up of strong durable materials, such as titanium and carbon, they are preferred over other cardiac prosthetic devices. (giichinese.com.tw)
  • in fact, a considerable amount of information on cardiac performance can be determined from the pressure versus volume plot (also known as pressure volume diagram ). (wikidoc.org)
  • Several physiologically relevant hemodynamic parameters such as stroke volume , cardiac output , ejection fraction , myocardial contractility can be determined from these loops. (wikidoc.org)
  • More on the cardiac surgery and heart valve devices market in the US can be found in a series of reports published by iData entitled the US Market Report Suite for Cardiac Surgery and Heart Valve Devices . (idataresearch.com)
  • To find out more about cardiac surgery market data or procedure data, register online or email us at [email protected] for a US Market Report Suite for Cardiac Surgery and Heart Valve Devices brochure and synopsis. (idataresearch.com)
  • Ergometric stress echocardiography can be used for a number of cardiac conditions where an assessment of cardiac and haemodynamic response to physiological stress is wanted. (tidsskriftet.no)
  • In this paper, performance of aortic heart valve prosthesis in different geometries of the aortic root is investigated experimentally. (asme.org)
  • The study aim was to report the early and mid-term clinical and hemodynamic results of a prospective trial investigating the clinical performance of the St. Jude Medical Regent 17 mm mechanical aortic valve prosthesis (SJMR-17). (icr-heart.com)
  • The SJMR-17 prosthesis might be employed with satisfactory postoperative clinical and hemodynamic outcome in patients with a small aortic annulus, especially in elderly patients, as an alternative to other valves, or to other surgical strategies such as annulus enlargement. (icr-heart.com)
  • Prediction of valve prosthesis-patient mismatch prior to aortic valve replacement: which is the best method? (bmj.com)
  • To predict the occurrence of valve prosthesis-patient mismatch (VP-PM) after aortic valve replacement (AVR), the surgeon needs to estimate the postoperative effective orifice area index (EOAI). (bmj.com)
  • The clinical impact of valve prosthesis-patient mismatch (VP-PM) 1 after aortic valve replacement (AVR) is controversial. (bmj.com)
  • Further refinement of the procedure and current developments focus on minimizing access site complications, reducing stroke risk, improving paravalvular sealing, avoiding heart block, and facilitating easy and accurate prosthesis implantation. (onlinejacc.org)
  • It is also intended for use in patients with a previously implanted aortic valve prosthesis that is no longer functioning adequately and requires replacement. (edwards.com)
  • Freedom from valve reoperation for prosthesis dysfunction and all other causes. (edwards.com)
  • There is a clear consensus that in young patients who require aortic valve replacement, a mechanical prosthesis is the preferred choice due to its durable prosthesis without fear of wear and tear over time. (bjcvs.org)
  • The Dobutamine test induces a substantial stress, well suitable for echocardiographic assessment of prosthesis valve function and can be performed in the majority of the patients. (biomedcentral.com)
  • Optimal hemodynamic performance of the valve prosthesis is particularly important in this setting [ 1 , 2 ]. (biomedcentral.com)
  • This prosthesis represents the recent generation of a bileaflet mechanical valve. (biomedcentral.com)
  • To date, no mechanical or bioprosthetic valve prosthesis has achieved the ideal profile described by Harken. (ahajournals.org)
  • However, we now recognize that some available valve prostheses may approach these ideal properties, and this type of long-term outcome study should guide prosthesis selection as we go forward. (ahajournals.org)
  • Three basic types of mechanical heart valves achieved notable clinical use: the ball-in-cage valve (eg, the Starr-Edwards valve prosthesis), the bileaflet valve (eg, the St. Jude valve prosthesis), and the single tilting-disc valve (eg, the Hall-Medtronic valve, the subject of the report by Svennevig et al). (ahajournals.org)
  • First, irrespective of theoretical design considerations and newly developed biomaterials, it is only the test of time that will reveal the long-term properties, durability, and outcomes associated with any valve prosthesis. (ahajournals.org)
  • Although contemporary engineering methods, such as finite element analysis and computational fluid dynamics, allow for optimized valve designs, on occasion these analyses have proved unreliable for the prediction of clinical performance, durability, and risk of thromboembolic complications after prosthesis implantation in patients. (ahajournals.org)
  • Second, in the case of aortic valve replacement, the size of the aortic prosthesis relative to the size of the patient is now known to be important, particularly for patients with left ventricular hypertrophy or left ventricular dysfunction, so that the prosthetic gradient will not be excessive and left ventricular afterload will be minimized. (ahajournals.org)
  • In this perspective, global and local flow parameters, valve dynamics and blood damage safety of the prosthesis, as well as their mutual interactions, have all to be accounted for when assessing the device functionality. (biomedcentral.com)
  • These valves can be rapidly implanted by the dilatation of a stent frame to ensure the anchoring of the prosthesis. (springer.com)
  • An echocardiogram performed in 2014 revealed normal biventricular systolic function, mechanical prosthesis in mitral position with maximum speed of 1.9 m/s, maximum gradient of 15 mmHg, mean gradient of 6 mmHg, severe tricuspid valve insufficiency, inferior vena cava measuring 15 mm with more than 50% collapse and pulmonary artery systolic pressure of 40 mmHg. (deepdyve.com)
  • INTRODUCTION However, almost a decade later of clinical use, numerous cases In 1960, Drs Nina Starr Braunwald and Andrew Morrow developed reported attrition of the posts in aortic prostheses that resulted in a mitral valve prosthesis with a flexible Dacron-polyurethane escape of the silastic ball and subsequent death. (deepdyve.com)
  • 9 It was a true 'resurrection' for Cribier and his whole team performing the first TAVI in an inoperable patient in 2002 10 , 11 using a transeptal antegrade approach and balloon-expandable aortic calve prosthesis, while at the same time in the USA, animal studies were being carried out to develop a transapical method of implantation. (bmj.com)
  • research topic of designing a radical mechanical heart valve prosthesis that leveraged novel design elements to mitigate anticoagulant therapy and improve patient quality of life. (vivitrolabs.com)
  • We examined the hemodynamic and clinical outcomes of aortic valve replacement in sexagenarians according to the type of prosthesis. (kjtcvs.org)
  • Of the 270 patients, 93 had a mechanical prosthesis (mechanical group), and 177 had a bioprosthesis (tissue group). (kjtcvs.org)
  • The type of aortic prosthesis was not associated with hemodynamic or clinical outcomes, except for anticoagulation-related events. (kjtcvs.org)
  • The aim of the present study was to investigate hemodynamic outcomes, mortality, valve-related complications, and anticoagulation-related events in patients in their 60s according to the type of aortic prosthesis used. (kjtcvs.org)
  • We aimed to evaluate in a single study the haemodynamic performances of five different widely used aortic valve prostheses: stentless porcine xenograft (Elan), stentless bovine pericardium (Pericarbon Freedom), stented porcine xenograft (Aspire), stented bovine pericardium (More) and mechanical (Ultracor). (bmj.com)
  • Stentless bioprostheses, whether porcine or bovine, displayed superior haemodynamics across nearly all echocardiographic parameters: lower gradients, larger effective orifice area, higher dimensionless severity index (DSI) and lower resistance, when compared with stented or mechanical prostheses. (bmj.com)
  • The stress performances of the stentless bioprostheses were similar to the mildly stenosed native aortic valve, whereas the performances of the stented and mechanical prostheses resembled that of native valves with mild-to-moderate stenoses. (bmj.com)
  • Conclusions Stentless bioprostheses displayed haemodynamics superior to stented or mechanical prostheses and had the closest performance to a normal, native aortic valve. (bmj.com)
  • The effective orifice area (EOA) of 383 patients who had undergone AVR between July 2000 and January 2005 with various aortic valve prostheses was obtained echocardiographically 6 months after the operation. (bmj.com)
  • As a consequence, hemodynamic performance of bileaflet valvular prostheses can be severely reduced. (unipd.it)
  • Thrombotic event classification was applied to five commercially available mechanical prostheses. (unipd.it)
  • 3 With the development of cardiopulmonary bypass in the 1950s, it became possible to replace diseased heart valves in their native location with prostheses. (ahajournals.org)
  • Since 2012, TAVI has been performed in more than 50 000 patients worldwide and a number of different aortic prostheses have since been developed. (bmj.com)
  • The present invention pertains to valves and in particular to tri-leaflet heart valve prostheses. (justia.com)
  • Early heart valve prostheses included ball-and-cage valves and disc-and-cage valves in which a ball or a disc was housed in a cage. (justia.com)
  • Transcatheter aortic valve replacement (TAVR) has been shown to reduce mortality in a randomized comparison with medical treatment ( 1 ) and to be noninferior to surgical aortic valve replacement in "high-risk operable" patients ( 2 ). (onlinejacc.org)
  • The company recently presented favorable study outcomes on its bioprosthetic surgical aortic valves featuring the Resilia tissue platform. (mddionline.com)
  • For example, the company recently announced COMMENCE study results showing that Edwards' bioprosthetic surgical aortic valves featuring its novel Resilia tissue platform continued to demonstrate favorable safety and hemodynamic performance through a median of four years follow up, with no events of structural valve deterioration (SVD). (mddionline.com)
  • The study is designed to evaluate the safety and effectiveness of surgical aortic heart valves with Resilia tissue in this patient population for up to five years, with a subset of patients being evaluated through 10 years. (mddionline.com)
  • Objectives The aim of this study was to assess the commissural alignment between bioprosthetic and native aortic valve leaflets following surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) and to investigate its impact on valvular function and coronary filling. (onlinejacc.org)
  • Surgical aortic valve replacement (SAVR) is a time-honored technique that has produced excellent results. (invasivecardiology.com)
  • 8 Surgical aortic valve replacement with either a mechanical or a biological valve is considered the golden standard of care in patients with severe AS. (springer.com)
  • Transcatheter aortic valve replacement (TAVR) has emerged as an effective alternative to conventional surgical aortic valve replacement (SAVR) in high-risk elderly patients with calcified aortic valve disease. (asme.org)
  • In patients of high, but not prohibitive, surgical risk, TAVI appears to provide similar outcomes to surgical aortic valve replacement (AVR), as demonstrated by the Placement of Aortic Transcatheter Valve (PARTNER) Cohort A ( 1 ). (annalscts.com)
  • However, the risks associated with surgical aortic valve replacement are increased in elderly patients and those with concomitant severe systolic heart failure or coronary artery disease, as well as in patients with comorbidities such as cerebrovascular and peripheral arterial disease, chronic kidney disease, and chronic respiratory dysfunction. (medscape.com)
  • The Carpentier-Edwards PERIMOUNT Magna Ease pericardial aortic bioprosthesis is intended for use in patients whose aortic valvular disease is sufficiently advanced to warrant replacement of their natural valve with a prosthetic one. (edwards.com)
  • Traditional surgical valve replacement has been the mainstay in the treatment of severe aortic valvular disease, and in the absence of serious comorbidities it is associated with low operative mortality. (bmj.com)
  • Heart valve segment was one of the largest segments in 2015 owing to rising prevalence of valvular disease and heart valve failure. (giichinese.com.tw)
  • 1,2,3 The Physiologic Fixation process, used in Medtronic's third generation tissue valves, was developed to address the problem of structural valve deterioration caused by mechanical stress and is designed to maintain native collagen structure and porcine aortic root and leaflet geometry. (medtronic.com)
  • Each of the leaflets is adapted to flex inwardly into and out of engagement with another leaflet so as to close and open the valve in response to force by blood pressure. (google.com)
  • 8 . The method of claim 7 , wherein a portion of the inner face of each leaflet is in a facing relationship with a portion of the inner face of another leaflet at the out-flow end of the valve so that the adjacent leaflets are partially closed. (google.com)
  • In 1959 in Cleveland, at Dr Kolff's impulse, he created the first 'single leaflet aortic valve' out of polyurethane. (wikipedia.org)
  • Thrombotic deposits of different weight and shape were placed on the valve leaflet and onto the annular housing, including the case of a thrombus completely blocking one leaflet. (unipd.it)
  • In this study, we hypothesized that straight tubular grafts may help maintain the native cylindrical position of the aortic valve commissures radially, resulting in preserved leaflet coaptation, reduced stresses, and potentially improved valve performance.METHODS: Using 3D printing, a left heart simulator with a valve-sparing root replacement model and a physiologic coronary circulation was constructed. (stanford.edu)
  • Immersing cardiovascular devices in a saturated calcification solution and exposing them to mechanical stresses associated with full opening and closing under normotensive backpressures creates leaflet calcification similar to that observed in vivo. (vivitrolabs.com)
  • Global and local hydrodynamics measurements and leaflet dynamics were analysed focusing on correlations between flow characteristics and valve motion. (biomedcentral.com)
  • 10 ], who described the interaction between vorticity and leaflet kinematics of a bileaflet mechanical heart valve (BMHV), is a first important step in that direction. (biomedcentral.com)
  • The location of this membrane can range from just below the aortic valve where it sometimes fuses with the leaflets, to lower within the LVOT where it can become attached to the anterior mitral valve leaflet (Figure 1 ) ( 12 ). (frontiersin.org)
  • We have developed a polymeric SAVR valve, which was optimized to reduce leaflet stresses and offer a thromboresistance profile similar to that of a tissue valve. (asme.org)
  • The valve is constructed by aligning the side edges of adjacent leaflets so that the leaflet inner faces engage each other, and then suturing the leaflets together with successive stitches along a fold line adjacent the side edges. (justia.com)
  • 1. A two-dimensional valve tissue pattern comprising a configuration that corresponds to the shape of tissue to be used in a reconstruction of at least one leaflet of a circulatory system valve, wherein the pattern comprises a configuration having three lobes arranged about a central coaption point within a central aperture. (freepatentsonline.com)
  • 12. The valve tissue pattern of claim 1 wherein when the two-dimensional valve tissue pattern is affixed to the annulus of a heart, said valve tissue pattern forms to provide a competent valve leaflet reconstruction. (freepatentsonline.com)
  • An elastic valve body and at least one leaflet are formed on a mold. (justia.com)
  • A bi-leaflet valve comprised an annular valve body in which two opposed leaflet occluders were pivotally mounted. (justia.com)
  • A tri-leaflet valve comprised an annular elastic valve body in which three flexible leaflets were mounted to a portion of the valve body, called a "stent," located at the circumference of the annulus. (justia.com)
  • Some tri-leaflet valves used rigid leaflets. (justia.com)
  • Durability is a desirable characteristic of prosthetic heart valves, including tri-leaflet heart valves, because replacing such a valve is both expensive and dangerous for the patient. (justia.com)
  • In one aspect, the invention features a valve comprising an elastic valve body, a leaflet having an attachment edge and a free edge, the leaflet being coupled to the valve body on the attachment edge and the free edge of the leaflet having an uncut edge. (justia.com)
  • The valve may further comprise a mold separation point on an inflow face of the leaflet away from the free edge. (justia.com)
  • In another aspect, the invention features an elastic valve body, a leaflet having an attachment edge and a free edge, the leaflet being coupled to the valve body on the attachment edge, and the free edge being molded. (justia.com)
  • In another aspect, the invention features a method of manufacturing a valve comprising forming an elastic valve body and a leaflet integral with the valve body, the leaflet having a free edge, the free edge having an uncut edge. (justia.com)
  • CT or MRI) to automatically extract the valve geometry and segregate root and leaflet regions. (butcherlab.com)
  • With the bicuspid aortic valve, the eccentric leaflet configuration leads to increased mechanical stress and clinical presentation occurs 2 decades earlier than that of degenerative trileaflet AS. (jaoa.org)
  • He began the clinical implantation of these valves in April 1969. (wikipedia.org)
  • This procedure of valve construction and implantation had been used in many centres in the world for about three years until it was realised that fascia lata did not perform well over longer periods of time in the high pressure environment of the left heart. (wikipedia.org)
  • These valves became incompetent after various durations after implantation - from 3 to 12 years. (wikipedia.org)
  • Although a small percentage of the pericardial valves continued to function normally for up to 26 years post-implantation, the majority of them had to be replaced between 6 and 14 years, and a few some time later. (wikipedia.org)
  • Patients underwent transesophageal echocardiography during and transthoracic echocardiography and multidetector computed tomography before and after valve implantation. (onlinejacc.org)
  • For all types of transcatheter heart valves (THVs), there was random valve implantation with regard to commissural alignment: 22% of THVs were aligned, 25% had mild CMA, 22% had moderate CMA, and 31% had severe CMA. (onlinejacc.org)
  • Objectives Valve hemodynamics and clinical outcomes among patients with a small aortic annulus who underwent transcatheter aortic valve implantation (TAVI) were examined. (onlinejacc.org)
  • In order to allow implantation of an appropriately sized prosthetic valve and prevent PPM in a patient with a small aortic annulus, an aortic annular enlargement procedure or a complete replacement of the aortic root may be necessary at the time of AVR. (onlinejacc.org)
  • Porcine stentless aortic valves provide excellent hemodynamic long-term results without significant rise of transvalvular pressure gradients or relevant insufficiencies until 14 years after implantation, leading to sustained decrease of left ventricular mass and improvement of left ventricular function. (biomedcentral.com)
  • 4 In 1960, the first successful mechanical aortic valve implantation in the orthotopic position was performed with short-term survival, 5 a key advance at that time. (ahajournals.org)
  • With this publication of the long-term results after implantation of the Hall-Medtronic valve, reliable long-term data are now available to assess the results with these 3 major types of mechanical aortic valves for up to 4 decades. (ahajournals.org)
  • Early clinical studies of the outcomes after heart valve implantation were often impeded by lack of uniform definitions for valve-related morbidity and mortality, such as bleeding and thromboembolic complications. (ahajournals.org)
  • 2 Since the first-in-man implantation in 2002,3 percutaneous aortic valve replacement (PAVR) is emerging as a safe and effective alternative technique to surgery for severe AVS treatment in patients judged to be poor candidates for surgery because of very high procedural risk. (invasivecardiology.com)
  • 4-6 The current indications for percutaneous valve implantation were recently described by the European Societies of Cardiology and Cardiosurgery. (invasivecardiology.com)
  • For the implantation, pledget-armed sutures are commonly used to secure the valve in either an intra- or supra-annular position. (springer.com)
  • Clinical studies evaluating these valves suggested safe implantation with associated reduced duration of cross-clamp and cardiopulmonary bypass time compared to conventional valves. (springer.com)
  • As transcatheter aortic valve replacement evolved and clinical outcomes improved, transcatheter treatment of degenerated bioprosthetic valves became possible using valve-in-valve (V-in-V) implantation, in which the new transcatheter valve is inserted inside the degenerated bioprosthesis. (onlinejacc.org)
  • V-in-V implantation has been successfully performed in degenerated aortic, mitral, pulmonic, and tricuspid bioprostheses as well as in pulmonary conduits. (onlinejacc.org)
  • The incremental cost-effectiveness of transapical transcatheter aortic valve implantation (TAVI) is ill-defined in high-risk patients where aortic valve replacement (AVR) is an option, and has not been ascertained outside a randomized controlled trial. (annalscts.com)
  • Analysis from this trial has determined that transfemoral, but not transapical, transcatheter aortic valve implantation (TAVI) is incrementally cost-effective relative to AVR. (annalscts.com)
  • Transcatheter aortic valve implantation (TAVI), a technique in which a bioprosthetic valve is inserted via a catheter and implanted within the diseased native aortic valve, was first implanted by Andersen in 1993 in a closed chest experimental pig model. (bmj.com)
  • This research was conducted to design and validate a BMHV that would have similar hemodynamic properties to native heart valves, enabling implantation without reliance on post-operative anti-coagulants. (vivitrolabs.com)
  • Percutaneous heart valve replacement (PHVR) is an emerging, catheter-based technology that allows for implantation of a prosthetic valve without open heart surgery. (annals.org)
  • These results will inform and validate hemodynamic stimulation regimens and functional targets for engineered valved conduits pre-implantation. (butcherlab.com)
  • AOA treatment is Medtronic's biochemical approach to mitigating calcification in the wall and leaflets of tissue valves. (medtronic.com)
  • Replacement aortic heart leaflets and method of making the same. (freepatentsonline.com)
  • The replacement aortic heart leaflets of the present invention include first and second segments. (freepatentsonline.com)
  • In another aspect of the invention, a standard set of replacement aortic leaflets is described. (freepatentsonline.com)
  • Methods are provided to provide replacement aortic leaflets based on traced outlines obtained from a surgically opened aortic ring. (freepatentsonline.com)
  • A prosthetic heart valve has leaflets made of a thin and flexible material. (google.com)
  • The side edges of adjacent leaflets are sewn together so as to form a substantially tubular valve structure having an in-flow end and an out-flow end. (google.com)
  • The entire Delrin structure was covered with seamless Dacron velour and at a later stage, the margins of the scalloped edges were covered with a thin layer of pericardium in an attempt to prevent or reduce the abrasion of the leaflets when in contact with this margin during valve closure. (wikipedia.org)
  • Background Expansion and geometry have been shown to affect leaflets of implanted transcatheter aortic bioprosthesis, but commissural alignment has not been studied. (onlinejacc.org)
  • In acute cases of AI, the main causes are infective endocarditis, aortic dissection, rupture of a congenital valve fenestration and traumatic rupture of the valve leaflets. (renalandurologynews.com)
  • The inability of the aortic valve leaflets to remain closed or coapted during diastole results in a portion of the left ventricular stroke volume leaking back from the aorta into the left ventricle. (renalandurologynews.com)
  • However, literature usually focuses on either global functionality, to assess whether the artificial valve overloads heart work, or local functionality, to quantify the shear stress field and its potential effects in terms of blood cells damage and leaflets degeneration. (biomedcentral.com)
  • Background ofthe Invention During normal physiological functions, the human heart valve opens up in response to the pressure of blood flow on its leaflets. (google.com)
  • The human heart valve also closes under the pressure exerted on the same leaflets when blood flow retrogrades. (google.com)
  • When the body is under no physical stress and the heart is beating at a normal resting state of about 70 beats per minute, the leaflets open by separation from one another and close by apposing each other, approximately 38 million times per year. (google.com)
  • The typical structure of the aortic valve had three semilunar leaflets in shape. (frontiersin.org)
  • The TAVR valve FSI simulation and Vivitro pulse duplicator experiments were compared in terms of the leaflets' kinematics and the effective orifice area. (asme.org)
  • Contemporary surgical bioprostheses generally incorporate leaflets derived from porcine valve leaflets or bovine pericardium (heterograft/xenograft). (onlinejacc.org)
  • A tubular prosthetic semilunar or atrioventricular heart valve is formed by cutting flat, flexible leaflets according to a pattern. (justia.com)
  • They consist of moveable "leaflets" that open and close in response to differential pressures on either side of the valve. (justia.com)
  • The mitral valve has two leaflets and the tricuspid valve has three. (justia.com)
  • Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. (curehunter.com)
  • When blood flowed in the reverse direction, the three leaflets engaged each other in a coaptive region, occluded the valve body annulus and prevented the flow of blood. (justia.com)
  • The valve leaflets were made from tissue, such as specially treated porcine or bovine pericardial tissue, or from a man-made material such as polyurethane or another biocompatible polymer. (justia.com)
  • Mechanical heart valves rely on reverse flow to close their leaflets. (siemens.com)
  • During the diastole, the blood flows back through the valve as the leaflets are closing. (siemens.com)
  • The leakage can also occur when the leaflets are fully closed from the gap between the leaflets and valve housing. (siemens.com)
  • First, we have developed printable (extrudable), photocrosslinkable, biologically derived, cell-friendly hydrogel building blocks that attain mechanical properties of the root sinus and leaflets. (butcherlab.com)
  • The smooth muscle of the aortic root wall behaves very differently than the fibroblasts within the valve leaflets, which in turn is associated with local extracellular matrix environments that vary considerably in their structural composition and biomechanical properties. (butcherlab.com)
  • The anterior and posterior leaflets of the mitral valve are supported by the papillary muscles and chordae tendinae during ventricular contraction and aid in the prevention of reverse flow in the left atrium. (emdocs.net)
  • Instead of the normal three leaflets or cusps, the bicuspid aortic valve has only two. (cardiachealth.org)
  • This is the sound of the valve leaflets opening and closing. (cardiachealth.org)
  • The latest addition to Medtronic's tissue valve portfolio, 3f ® Aortic Bioprosthesis, is the only pericardial tissue valve designed to function like a native human aortic valve. (medtronic.com)
  • Pressure fixation of valves can compromise the function and durability of the bioprosthesis. (medtronic.com)
  • None of these showed a better performance than the original Ionescu valve with the exception of a pericardial valve modified and built by Edwards Laboratories and commercialised under the name of 'Carpentier-Edwards Pericardial Bioprosthesis. (wikipedia.org)
  • The new St Jude Trifecta versus Carpentier-Edwards Magna and Magna Ease aortic bioprosthesis: Is there a hemodynamic superiority? (edwards.com)
  • Hemodynamic Stability During 17 Years of the Carpentier-Edwards Aortic Pericardial Bioprosthesis. (edwards.com)
  • The Carpentier-Edwards aortic pericardial valve portfolio is built upon the PERIMOUNT bioprosthesis design. (edwards.com)
  • Carpentier-Edwards PERIMOUNT pericardial aortic bioprosthesis. (edwards.com)
  • We describe our experience with sutureless Perceval (Sorin Group, Italy) aortic bioprosthesis. (lww.com)
  • Aortic valve replacement with Perceval bioprosthesis is a safe and feasible procedure associated with low mortality and excellent hemodynamic performance. (lww.com)
  • Influence of age on valve related events with Carpentier-Edwards pericardial bioprosthesis. (who.int)
  • Concomitant procedures were mitral valve surgery (n=74), tricuspid valve repair (n=21), CABG (n=41), myectomy (n=3) and ascending aorta replacement (n=2). (lww.com)
  • On the right (pulmonary) side of the heart are: (1) the tricuspid valve, located between the right atrium and the right ventricle, and (2) the pulmonary valve, located between the night ventricle and the pulmonary artery. (justia.com)
  • The mitral and tricuspid valves are referred to as "atrioventricular valves" because they are situated between an atrium and ventricle on each side of the heart. (justia.com)
  • The Impella RP heart pump can be inserted through a standard catheterization procedure through the femoral vein and into the right atrium, across the tricuspid and pulmonic valves, and into the pulmonary artery, to support a patient's pulmonary circulation and provide hemodynamic stability. (protectedpci.eu)
  • The heart is composed of four valves: the mitral and tricuspid valves (atrioventricular valves) and the pulmonic and aortic valves (semilunar valves). (emdocs.net)
  • We read with keen interest the report by Hui and colleagues1 on the stability of nonaneurysmal sinus of Valsalva after aortic valve and ascending aorta replacement in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). (medworm.com)
  • Our work in the minimally invasive treatment of other heart valves also bears watching: Abbott is working towards a tricuspid heart valve repair offering - leveraging the clip-based technology from its MitraClip product - and is also currently conducting a trial its transcatheter aortic valve repair (TAVR) offering, Portico* , in the U.S. (abbott.com)
  • Objectives The aim of this study was to demonstrate feasibility and short- and midterm clinical outcomes with a new self-expanding transcatheter heart valve and motorized delivery system. (onlinejacc.org)
  • Background Refining transcatheter aortic valve replacement with newly designed bioprostheses and delivery systems is anticipated to facilitate the procedure, reduce the risk of complications, improve outcomes, and widen applicability. (onlinejacc.org)
  • Conclusions Transcatheter aortic valve replacement with the CENTERA transcatheter heart valve and motorized delivery system is feasible and can lead to good short- and midterm clinical and hemodynamic outcomes. (onlinejacc.org)
  • Conclusions In high-risk patients with severe AS and a small aortic annulus, TAVI is associated with good post-procedural valve hemodynamics and clinical outcomes. (onlinejacc.org)
  • Herein, we review our single-centre experience with heart-lung transplantation over the past 10 years.METHODS: We retrospectively reviewed 49 heart-lung transplant recipients between 2008 and 2018 to investigate the patient characteristics and outcomes while comparing those results across 2 cohorts (2008-2015, Era I, n=30 and 2016-2018, Era II, n=19).RESULTS: Our patient demographics and waitlist time did not significantly change over time. (stanford.edu)
  • Our primary focus at The Baird Institute is to encourage and fund research to improve the surgical outcomes and quality of life for patients facing heart or lung surgery. (bairdinstitute.org.au)
  • The report by Svennevig and colleagues in this issue of Circulation will stand as an important contribution to our knowledge of the outcomes after heart valve replacement. (ahajournals.org)
  • Initial experience suggests that outcomes compare favorably with conventional valve surgery in selected patients with comorbidities such as advanced age. (invasivecardiology.com)
  • The objectives of the study are to provide nationally representative estimates of complications following aortic and mitral valve replacements and to quantify the impact of different types of complications on in-hospital outcomes. (redorbit.com)
  • Complications are prevalent and exert a considerable influence on outcomes following aortic and mitral valve replacements. (redorbit.com)
  • There is little published data providing population-based estimates of complications following heart valve replacement surgeries or describing the impact of complications on outcomes. (redorbit.com)
  • The objectives of the current study are to provide nationally representative estimates of complications following aortic and mitral valve replacement surgeries and to quantify the relative impact of different types of complications on in-hospital outcomes including in-hospital mortality, length of stay (LOS), and hospital charges. (redorbit.com)
  • Outcomes after mechanical aortic valve replacement in children and young adults with congenital heart disease. (childrenshospital.org)
  • Outcomes and costs attributed to transapical TAVI with the Edwards SAPIEN valve (Edwards Lifesciences, Irvine, CA) and tissue AVR for the management of high-risk patients with severe AS were evaluated in a decision-analytic model. (annalscts.com)
  • The question of which type of prosthetic aortic valve leads to the best outcomes in patients in their 60s remains controversial. (kjtcvs.org)
  • Early and late mortality, major adverse valve-related events, anticoagulation-related events, and hemodynamic outcomes were assessed. (kjtcvs.org)
  • To date, little overlap exists between the patient populations who have received surgical versus percutaneous aortic valve replacement, and long-term outcomes associated with PHVR have rarely been reported. (annals.org)
  • We congratulate Hui and colleagues1 on their excellent outcomes and for adding to the increasing literature supporting sinus of Valsalva preservation in the context of aortic valvulopathy with isolated ascending aorta or arch aneurysm. (medworm.com)
  • From children born with valvular congenital abnormalities, adults affected by rheumatic heart fever to elderly developing atherosclerosis, heart valves are never spared from pathologies. (bjcvs.org)
  • Address for correspondence: Gian Paolo Ussia MD FSCAI, Director of Interventional Structural and Congenital Heart Disease Programme, Invasive Cardiology, Division of Cardiology - Ferrarotto Hospital, University of Catania, Catania, Italy. (invasivecardiology.com)
  • Although a genetic etiology had been initially proposed, the association between DSS and left ventricle (LV) geometrical abnormalities has provided more support to a hemodynamic etiology by which congenital or post-surgical LVOT geometric derangements could generate abnormal shear forces on the septal wall, triggering in turn a fibrotic response. (frontiersin.org)
  • DSS occurs within about 6% of children with congenital heart defects ( 1 , 2 ) and is responsible for 8-30% of total LVOT obstructions in children and up to 20% of obstructions that require intervention ( 3 , 4 ). (frontiersin.org)
  • Heart valves may exhibit abnormal anatomy and function as a result of congenital or acquired valve disease. (justia.com)
  • Congenital valve abnormalities may be well-tolerated for many years only to develop a life-threatening problem in an elderly patient, or may be so severe that emergency surgery is required within the first few hours of life. (justia.com)
  • 4. Congenital heart disease and pulmonary hypertension4.1 Congenital heart disease is present in 0.8-0.9% of live births.Lesions vary in severity, but even patients with complex lesions now survive to childbearing years.In large international surveys of pregnancy and heart disease, two-thirds of cases had congenital heart disease and 5% had a PH.However, congenital heart disease and PH are rare causes of maternal death. (dxy.cn)
  • In most women with congenital heart disease, pregnancy is well tolerated. (dxy.cn)
  • 4.2.3.1 Cyanotic congenital heart disease is usually repaired before pregnancy, but some balanced, inoperable, or palliated cases do reach childbearing age.Maternal complications (HF, thrombosis, arrhythmias, and endocarditis) occur in ≥15% of cyanotic pregnant patients. (dxy.cn)
  • Pathology of valved venous homografts used as right ventricle-to-pulmonary artery conduits in congenital heart disease surgery. (childrenshospital.org)
  • Name 4 risk factors for developing congenital heart defects. (cueflash.com)
  • 80% of congenital heart disease is due to unknown cause 1. (cueflash.com)
  • With a nod to tradition, it should be noted that there are 3 forms of AS from the perspective of congenital heart disease. (jaoa.org)
  • Bicuspid aortic valve disease (BAV) is a congenital condition (present at birth) and occurs in about two percent of the population. (cardiachealth.org)
  • Beyond valvular solutions, Abbott's structural heart business is a leader in occlusion devices that treat or close openings in the heart caused by congenital heart defects. (abbott.com)
  • In the U.S. alone, congenital heart defects (CHD) affect nearly 1 percent - about 40,000 - births each year. (abbott.com)
  • Vascular access in children with congenital heart defects. (cincinnatichildrens.org)
  • Functional characterization of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease. (cincinnatichildrens.org)
  • The method can also provide important information about pulmonary hypertension and congenital heart defects. (tidsskriftet.no)
  • Background In patients being considered for aortic valve replacement, there remains controversy over which design or tissue offers the best performance. (bmj.com)
  • The objective of this investigation is to establish a set of parameters, which are associated with abnormal flow patterns due to the flow through a prosthetic heart valve implanted in the patients that had certain types of valve diseases prior to the valve replacement. (asme.org)
  • And while transcatheter valves are a great solution for many patients, there will always be patients who need to have a surgical valve replacement. (mddionline.com)
  • The study enrolled 694 patients and 144 of them (21%) were under the age of 60 when they had surgical valve replacement. (mddionline.com)
  • Patients undergoing valve replacement are living long lives and remaining more active through their later years, increasing the need for advanced valve replacement technologies," said John Puskas, MD, principal investigator for the COMMENCE study. (mddionline.com)
  • TAVI is an alternative to aortic valve replacement (AVR) in high-risk patients, but few data exist on the results of TAVI in patients with a small aortic annulus. (onlinejacc.org)
  • Surgical replacement of the diseased aortic valve remains the definitive intervention for most diseases. (bjcvs.org)
  • Despite evidence supporting pharmacological management, valve replacement is the only definitive treatment to date. (bjcvs.org)
  • 7 to 16 years after aortic valve replacement, 54 patients (mean age at operation 53.1 ± years) received echocardiography and clinical examination. (biomedcentral.com)
  • Modeling conduit choice for valve-sparing aortic root replacement on biomechanics with a 3-dimensional-printed heart simulator. (stanford.edu)
  • OBJECTIVE: The optimal conduit for valve-sparing aortic root replacement is still debated, with several conduit variations available, ranging from straight tubular grafts to Valsalva grafts. (stanford.edu)
  • Iatrogenic causes include aortic balloon valvotomy or a failed surgical valve repair or replacement. (renalandurologynews.com)
  • 1 This article, along with other extensive published series of patients followed up for as many as 4 decades after mechanical heart valve replacement, now help form the basis on which present and future decisions are made for patients with valvular heart disease. (ahajournals.org)
  • Patients, who have been done mitral valve replacement, were selected randomly to undergo the stress echocardiography. (wjcmpr.com)
  • Satisfactory transvalvular haemodynamic conditions and heart pump function are usually restored at the short- and mid-term after valve replacement. (biomedcentral.com)
  • Patients referred for aortic valve replacement (AVR) may benefit from sutureless technology to reduce mortality and morbidity and to facilitate minimally invasive approach. (lww.com)
  • The aim of the study was to report the results of hybrid aortic valve replacement through right anterior minithoracotomy (RAT-AVR)/PCI and conventional AVR/CABG surgery for patients with aortic valve and coronary artery disease. (lww.com)
  • Currently, adults who undergo replacement of diseased valves by either mechanical prosthetic or tissue valves (including bioprosthetic valves [porcine aortic valve or bovine pericardial xenograft], cadaveric allograft, or pulmonary-to-aortic autograft valves [Ross procedure]) generally have enhanced survival and quality of life. (springer.com)
  • The most immediate need for heart valve tissue engineering and regeneration technology is in the pediatric and young adult population in which the results of valve replacement are not as favorable as those in older adults. (springer.com)
  • Design objectives for and characteristics of replacement heart valves. (springer.com)
  • When bioprosthetic valves degenerate, reoperative valve replacement is the current standard of care ( 3-5 ). (onlinejacc.org)
  • This invention relates to heart valves, and more particularly relates to replacement of diseased or injured heart valves. (justia.com)
  • Valve repair and valve replacement surgery is described and illustrated in numerous books and articles, and a number of options, including artificial mechanical valves and artificial tissue valves, are currently available. (justia.com)
  • A total of 43 909 patients underwent aortic valve replacement as the primary procedure during the study period and 16 516 patients underwent mitral valve replacement. (redorbit.com)
  • The NIS is a 20% stratified sample of all non- federal hospitals in the United States and contains up to 8 million records from approximately 1 000 hospitals in 35 states.15 All patients who underwent aortic valve replacement (ICD-9-CM codes of '35.21' or '35.22') or mitral valve replacement (ICD-9-CM codes of '35.23' or '35.24') as primary procedures were selected for analyses. (redorbit.com)
  • If you need to have a heart valve replacement, you have several choices to consider when discussing your heart valve options with your medical professional. (heart.org)
  • The ideal replacement valve offers excellent valve function and works in coordination with the entire circulatory system to protect each part from damage. (heart.org)
  • The ideal replacement valve also offers long-term durability without significantly increasing the risk of dangerous blood clots or bleeds. (heart.org)
  • They are the most long-lasting type of replacement valve, and most of these manufactured valves will last throughout the remainder of the patients' lifetime. (heart.org)
  • For a young person with a tissue valve replacement, the need for additional surgery or another valve replacement later in life is highly likely. (heart.org)
  • We retrospectively reviewed 270 patients in their 60s who underwent first-time aortic valve replacement from 1995 to 2011. (kjtcvs.org)
  • Transcatheter aortic valve replacement (TAVR) was developed as an alternative to the surgical approach in this high-risk and inoperable population. (medscape.com)
  • No established indications or guidelines exist yet for transcatheter aortic valve replacement (TAVR) in the United States. (medscape.com)
  • However, select patients may also benefit from aortic valve replacement before the onset of symptoms. (aafp.org)
  • Surgical valve replacement is the standard of care for patients at low to moderate surgical risk. (aafp.org)
  • Transcatheter aortic valve replacement may be considered in patients at high or prohibitive surgical risk. (aafp.org)
  • Transcatheter aortic valve replacement is recommended for patients who have an indication for aortic valve replacement but are at prohibitive surgical risk. (aafp.org)
  • Transcatheter valve replacement is also a reasonable alternative to surgical replacement in high-risk patients. (aafp.org)
  • This technology also enables accelerated pre-clinical evaluation of novel surgical approaches for living valve replacement before their evaluation in animal models. (butcherlab.com)
  • 1 Over the past decade, the number of aortic valve replacement operations has doubled and, because of the anticipated growth of the older adult population, it is predicted to double again over the next 20 years. (jaoa.org)
  • 1 , 2 Increasingly, AS is the focus of interventional cardiologists who are typically performing fewer coronary angioplasty procedures and more percutaneous aortic valve replacement procedures. (jaoa.org)
  • Due to the artificial material involved, patients who receive a mechanical valve replacement need to take an anticoagulant medication for the rest of their lives. (cardiachealth.org)
  • Some patients who have a mechanical valve replacement report a valve clicking noise at times. (cardiachealth.org)
  • Most patients who receive a biological valve replacement do not need to take life-long anticoagulant therapy after surgery, unless they have other conditions (such as atrial fibrillation) that require these medications. (cardiachealth.org)
  • Abbott recently received U.S. Food and Drug Administration approval for a new 15mm pediatric heart valve, the world's smallest mechanical heart valve that allows doctors to treat newborns and babies in need of a mitral or aortic valve replacement. (abbott.com)
  • Transcatheter Aortic Valve Replacement (TAVR) is covered by Evidence Development (CED) Coverage provided by the Centers for Medicare & Medicaid Services (CMS). (giichinese.com.tw)
  • In the past years, it has evolved as a minimally invasive alternative treatment for surgical valve replacement. (giichinese.com.tw)
  • As main and general result, this study validates the potential of the integrated strategy for performance assessment of any prosthetic valve thanks to its capability of highlighting the complex interaction between the different physical mechanisms that govern transvalvular haemodynamics. (biomedcentral.com)
  • Ever since 1950, when blood oxygenators made open heart surgery feasible, it has been possible to treat some forms of heart disease by replacing one of the patient's heart valves with a prosthetic valve. (justia.com)
  • Evaluated were NYHA class, transvalvular gradients, estimated aortic valve orifice area, degree of aortic valve insufficiency, left ventricular mass and function. (biomedcentral.com)
  • Captured and analyzed were NYHA class, maximum and mean transvalvular pressure gradient, effective aortic valve orifice area (EOA), degree of aortic valve insufficiency, left ventricular mass and left ventricular function. (biomedcentral.com)
  • Acute aortic insufficiency is typically the result of either acute aortic dissection or endocarditis. (emdocs.net)
  • 6 Clinical results show excellent thrombogenic and hemodynamic performance 7,8 and outstanding durability and implantability. (medtronic.com)
  • Ahmad, Kamarul 2017-07-26 00:00:00 Even though the mechanical heart valve (MHV) has been used routinely in clinical practice for over 60 years, the occurrence of serious complications such as blood clotting remains to be elucidated. (deepdyve.com)
  • Specific valve diseases were classified into two clinical categories and were correlated with the corresponding changes in aortic root geometry while keeping the aortic base diameter fixed. (asme.org)
  • Of the identified 64 patients with the originally implanted valve still in place 54 patients gave informed consent to the clinical trial and received clinical examination and echocardiography. (biomedcentral.com)
  • Aging of the aortic valve (AV) is characterized by cuspal thickening [1] and loss of extensibility [2] , which can lead to progressive changes in valve function with age, but these are not usually themselves of clinical significance. (biomedsearch.com)
  • Lancellotti P, Pellikka PA, Budts W, et al: The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. (wjcmpr.com)
  • 12 Hence, rapid-deployment valve systems have been recently introduced to the clinical arena. (springer.com)
  • Lastly, we analyze challenges to the field and suggest future directions for both preclinical and translational (clinical) studies that will be needed to address key regulatory issues for safety and efficacy of the application of tissue engineering and regenerative approaches to heart valves. (springer.com)
  • Emerging clinical evidence indicates that these valves may get damaged during crimping and deployment-leading to valvular calcification, thrombotic complications, and limited durability. (asme.org)
  • Despite some core similarities to transcatheter therapy of native valve disease, V-in-V therapy poses unique clinical and anatomic challenges. (onlinejacc.org)
  • The available evidence is inadequate to determine the most appropriate clinical role for PHVs or the specific patient populations for whom these valves might eventually be indicated. (annals.org)
  • The bicuspid aortic valve is also associated with an aortopathy, in which ascending aortic root dilatation or aneurysm occurs, further complicating this clinical condition. (jaoa.org)
  • Abbott's AMPLATZER Amulet* left atrial appendage (LAA) closure product is under clinical trial for the growing U.S. market, and further, Abbott has the first approved product on the U.S. market to treat patent foramen ovale (PFO), or a hole in the heart, with a minimally invasive PFO closure device - AMPLATZER PFO Occluder - that is proven to reduce risk of recurrent stroke in patients with a PFO defect. (abbott.com)
  • To understand just how life-changing this new structural heart solution is, watch the below video of Sadie, the now 3-year-old whose life was saved by Abbott's innovative heart valve technology when she was just a baby and the first infant to be treated as part of the clinical trial for the 15mm valve. (abbott.com)
  • These products, sold by Dextera Surgical under the Cardica brand name, have demonstrated long-term reliable clinical performance for more than a decade. (idataresearch.com)
  • The innovative, patented Cinch System, exclusively offered with the Mosaic ® and Hancock ® II aortic and mitral bioprostheses, draws the stent posts in to provide better visualization and more room for tying behind the stent posts. (medtronic.com)
  • The Complete Supraannular Concept, In Vivo Hemodynamics of Bovine and Porcine Aortic Bioprostheses. (edwards.com)
  • Nonetheless, in long term follow-up survival between mechanical and stented bioprostheses slightly favored the latter [ 6 ], despite the higher risk of reoperation. (biomedcentral.com)
  • The superior hemodynamic properties of SAVR may lead to a higher durability compared to stented bioprostheses. (biomedcentral.com)
  • Although the current devices are approved for stenotic native valves, percutaneous approaches to treat degenerated aortic bioprostheses have been reported. (invasivecardiology.com)
  • In younger patients, these valves will not last as long, but will still last longer than previous generations of bioprostheses. (cardiachealth.org)
  • 2017 Aug;121(5):512-524 PMID: 28701309 Abstract RATIONALE: Thoracic aortic aneurysm (TAA) is a. (bairdinstitute.org.au)
  • This study reports the healthy adult pulmonary and aortic valve proteomes characterized by LC-MS/MS, resulting in 2710 proteins expressed by 1513 genes, including over 300 abundant ECM proteins. (nih.gov)
  • Immunofluorescent investigations demonstrated that these proteins are functionally distributed within the pulmonary and aortic valve structure, indicative of important contribution to valve function. (nih.gov)
  • Symptoms of left-sided heart failure (dyspnea on exertion, orthopnea, paroxysmal nocturnal dyspnea and eventual pulmonary edema) occur in the presence of left ventricular dysfunction. (renalandurologynews.com)
  • Only autografts (such as Ross valves transplanted from the pulmonary-to-aortic position in an individual) presently are viable, 120 but the Ross procedure is technically difficult, risky, only serves a small patient subset, and has controversial results, including uncertainty over whether the grafts will grow commensurate with recipient growth. (springer.com)
  • Factors that have been shown to portend a higher reoperative risk include advanced age, renal failure, pulmonary disease, cognitive impairment, reduced ejection fraction, higher New York Heart Association functional class, need for concomitant bypass surgery, need for more than 1 reoperation, and reoperation for failed mitral valves (higher risk than aortic) ( 3,5-12 ). (onlinejacc.org)
  • These two valves direct de-oxygenated blood from the body through the right side of the heart and into the pulmonary artery for distribution to the lungs, where the blood becomes re-oxygenated in order to begin the circuit anew. (justia.com)
  • The aortic and pulmonary valves each have three cusps. (justia.com)
  • The Impella RP® heart pump delivers blood from the inlet area, which sits in the inferior vena cava, through the cannula to the outlet opening near the tip of the catheter in the pulmonary artery. (protectedpci.eu)
  • PH has many causes and is defined by an elevation in mean pulmonary arterial pressure (PAP)≥25 mmHg at right heart catheterization. (dxy.cn)
  • After heart catheterization, hemodynamic parameters were invasively monitored: a course of levosimendan and initiation of diuretics led to a decrease of pulmonary capillary wedge pressure (from maximum 35 to 24 mmHg). (hindawi.com)
  • In severe AR, increased LV pressure may cause early closure of the mitral valve prior to atrial systole and exacerbate pulmonary congestion as the atria contracts against a closed valve. (emdocs.net)
  • The area enclosed by the PV loop is a measure of the ventricular stroke work, which is a product of the stroke volume and the mean aortic or pulmonary artery pressure (afterload), depending on whether one is considering the left or the right ventricle. (wikidoc.org)
  • Freehand insertion of stentless fascia lata aortic valves was also used in a small number of cases with similar results. (wikipedia.org)
  • Stentless aortic valve replacements show improved hemodynamics due to larger orifice area and lower transvalvular gradients in short and mid-term follow-up. (biomedcentral.com)
  • All currently food and drug administration approved TAVR devices use tissue valves that were adapted to but not specifically designed for TAVR use. (asme.org)
  • This study compares the polymeric SAVR valve's hemodynamic performance and mechanical stresses to a new version of the valve-specifically designed for TAVR. (asme.org)
  • The TAVR valve had 42% larger opening area and 27% higher flow rate versus the SAVR valve, while WSS distribution and mechanical stress magnitudes were of the same order, demonstrating the enhanced performance of the TAVR valve prototype. (asme.org)
  • TAVR is a minimally invasive, catheter-based procedure to replace the function of the aortic valve. (medscape.com)
  • Yet no long-term follow-up of the hemodynamic performance of SAVR with its implication on durability in younger patients has been published. (biomedcentral.com)
  • PPM has in turn been associated with diminished extent of regression of left ventricular hypertrophy, reduced coronary flow reserve, increased incidence of congestive heart failure, diminished functional capacity, and increased risk of early and late mortality ( 4-7 ). (onlinejacc.org)
  • Impella catheters offer hemodynamic support and more safety during cardiogenic shock or percutaneous coronary interventions (Protected PCI). (protectedpci.eu)
  • Weixler VHM, Zurakowski D, Baird CW, Guariento A, Piekarski B, Del Nido PJ, Emani S. Do patients with anomalous origin of the left coronary artery benefit from an early repair of the mitral valve? (childrenshospital.org)
  • Three-Patch Aortic Root Reconstruction With Extended Left Main Coronary Artery Patch Augmentation in Neonates and Infants. (childrenshospital.org)
  • Your medical professional may refer to this as "excellent hemodynamic performance. (heart.org)
  • Medtronic's tissue valve expertise benefits from more than 40 years of experience, research, and skill, allowing us to provide the world with not only choice, but with advanced features that make a difference in patients' lives. (medtronic.com)
  • Our third generation of tissue valve technology brings you AOA ® tissue treatment, the Physiologic Fixation™ process, and now, the Cinch ® Implant System - demonstrating our commitment to innovation. (medtronic.com)
  • Age, calcium metabolism and glutaraldehyde pretreatment all contribute to the failure of tissue valves. (medtronic.com)
  • 3 . The heart valve of claim 1 , wherein the thin and flexible material comprises pericardial tissue. (google.com)
  • In a continuous search to create a tissue heart valve which could be used without anticoagulant treatment, Ionescu created a novel artificial valve. (wikipedia.org)
  • Using autologous fascia lata tissue (the fibrous membrane which covers the outside aspect of the thigh muscles) taken from the patient and used to construct the valve during the operation by mounting the living fascia on a Dacron-covered titanium frame in the shape of a three cusp valve. (wikipedia.org)
  • It is flexible and shock absorbent, essential qualities for a tissue heart valve support. (wikipedia.org)
  • One should however keep in mind that any single investigator should resist the temptation to write a review of such a complex matter as tissue heart valves, and to cover the subject completely and fairly. (wikipedia.org)
  • Edwards' Resilia bovine pericardial tissue incorporates a novel integrity-preservation technology that may eliminate a key factor in calcification leading to valve deterioration. (mddionline.com)
  • It was important to enroll a significant number of younger patients in the COMMENCE study, Chopra said, because the Resilia tissue is designed to last longer than previous generations of valve tissue technology. (mddionline.com)
  • The absence of structural valve deterioration in these patients is extremely encouraging and highlights the potential of valves containing Resilia tissue for patients who may otherwise opt for a mechanical valve, which requires long-term use of blood thinning medications. (mddionline.com)
  • The Resilia tissue platform was created with a vision to extend valve durability for a more active patient population, while reducing the need for long-term use of blood-thinning medication," Chopra said. (mddionline.com)
  • Additional five-year data from a European feasibility study of a bioprosthetic aortic valve with RESILIA tissue were presented last month at the Heart Valve Society's annual meeting. (mddionline.com)
  • ViVitro Labs calcification testing is available for cardiovascular devices including prosthetic valves and conduits and other cardiovascular devices that contain tissue, or may be susceptible to calcification. (vivitrolabs.com)
  • This test can give bulk distribution throughout the valve, or highlight calcium deposit through the thickness of the tissue depending on the resolution selected. (vivitrolabs.com)
  • However, they may succumb to premature tissue calcification, which is triggered by calcific aortic valve disease. (vivitrolabs.com)
  • This review focuses on the engineering of heart valve tissue, a goal which involves a unique combination of biological, engineering, and technological hurdles. (springer.com)
  • Following a discussion of the fundamental principles of tissue engineering applicable to heart valves, we examine three approaches to achieving the goal of an engineered tissue heart valve: (1) cell seeding of biodegradable synthetic scaffolds, (2) cell seeding of processed tissue scaffolds, and (3) in-vivo repopulation by circulating endogenous cells of implanted substrates without prior in-vitro cell seeding. (springer.com)
  • Although modest progress has been made toward the goal of a clinically useful tissue engineered heart valve, further success and ultimate human benefit will be dependent upon advances in biodegradable polymers and other scaffolds, cellular manipulation, strategies for rebuilding the extracellular matrix, and techniques to characterize and potentially non-invasively assess the speed and quality of tissue healing and remodeling. (springer.com)
  • Potential applications of tissue engineering in regenerative medicine range from structural tissues (e.g., skin, cartilage, bone) to complex organs (e.g., heart and other components of the cardiovascular system, liver, kidney, pancreas). (springer.com)
  • 14 , 119 , 122 , 176 This review focuses on the application of tissue engineering technology to heart valves. (springer.com)
  • Advantages of an engineered tissue heart valve would likely include nonthrombogenicity, infection resistance, and cellular viability. (springer.com)
  • Acquired valve disease may result from causes such as rheumatic fever, degenerative disorders of the valve tissue, bacterial or fungal infections, and trauma. (justia.com)
  • A new and unique, optimized, two-dimensional heart valve tissue pattern, valve, and a method of reconstructing a three-dimensional semilunar heart valve, or portion thereof. (freepatentsonline.com)
  • 2. The valve tissue pattern of claim 1 wherein each lobe is comprised of an outer perimeter and an inner edge. (freepatentsonline.com)
  • 3. The valve tissue pattern of claim 2 wherein the outer perimeter of each lobe has a rounded surface. (freepatentsonline.com)
  • 4. The valve tissue pattern of claim 3 wherein the inner edge of each lobe is linear. (freepatentsonline.com)
  • 5. The valve tissue pattern of claim 1 wherein said aperture has three sides. (freepatentsonline.com)
  • 6. The valve tissue pattern of claim 5 wherein the three lobes are asymmetrically arranged about the central coaption point. (freepatentsonline.com)
  • 7. The valve tissue pattern of claim 5 wherein the central aperture is a triangle. (freepatentsonline.com)
  • 8. The valve tissue pattern of claim 5 wherein the central aperature corresponds to the shape of an equilateral triangle in which each of the edges of said equilateral triangle correspond to a line of coaption on each of the lobes. (freepatentsonline.com)
  • 11. The valve tissue pattern of claim 10 wherein each lobe meets adjacent lobes at commisure areas located at the point where the outer perimeter of each lobe meets the inner edge of the same lobe. (freepatentsonline.com)
  • 13. The valve tissue pattern of claim 5 wherein the three lobes are arranged in substantial radial symmetry about the central coaption point. (freepatentsonline.com)
  • 14. The valve tissue pattern of claim 9 wherein when the valve tissue pattern is affixed to the annulus of a heart, and said valve pattern forms a three-dimensional valve, the line of coaption of each lobe meets with the lines of coaption of the other two lobes. (freepatentsonline.com)
  • 15. The valve tissue pattern of claim 9 wherein the three lobes meet at a central coaption point. (freepatentsonline.com)
  • 16. The valve tissue pattern of claim 1 wherein the pattern is comprised of autologous, homologous or heterologous tissue. (freepatentsonline.com)
  • 17. The valve tissue pattern of claim 16 wherein said tissue is pericardium. (freepatentsonline.com)
  • 18. The valve tissue pattern of claim 1 wherein the two-dimensional tissue pattern is derived from unwrapping the three-dimensional geometry of a native anatomical circulatory system valve. (freepatentsonline.com)
  • Tissue valves are created from animal donors' valves or other animal tissue that's strong and flexible. (heart.org)
  • Tissue valves can last 10-20 years, and usually don't require the long-term use of medication. (heart.org)
  • The tissue group had a higher mean age and prevalence of preoperative stroke than the mechanical group. (kjtcvs.org)
  • The 10-year survival rate was 83% in the mechanical group and 90% in the tissue group. (kjtcvs.org)
  • We have pioneered 3D tissue printing technology to create anatomically accurate and mechanically heterogeneous fully cellularized living heart valve conduits. (butcherlab.com)
  • These innovative technologies enable precise design of conduit macro -geometry to affect native-like valve tissue formation. (butcherlab.com)
  • We believe these heterogeneous anatomically precise components are essential to improving the success of heart valve tissue engineering. (butcherlab.com)
  • We are studying how these parameters control valve tissue growth and remodeling in vitro, and whether engineered valves respond similarly to these conditions. (butcherlab.com)
  • Heart valve tissue matrix is embedded with a constellation of smooth muscle and fibroblast like phenotypes whose coordination is essential for proper tissue function. (butcherlab.com)
  • We use novel 3D tissue biofabrication techniques to replicate these heterogeneous matrix configurations and test how they direct differentiation of autologously accessible stem cells (e.g. bone marrow, fat tissue) towards valve phenotypes and promote interfacial integration. (butcherlab.com)
  • Re-operations for mechanical failures or tissue in-growth are uncommon. (cardiachealth.org)
  • Biological valves (also called tissue valves) are made of tissue, but they may also have some artificial parts to give the valve support and aid placement. (cardiachealth.org)
  • Biological valves may be made from cow tissue (bovine), pig tissue (porcine) or pericardial tissue from other species. (cardiachealth.org)
  • In the elderly, calcific AS often progresses from aortic sclerosis, aortic valve thickening involving lipid accumulation and calcium deposition, involving processes that are also found in atherosclerosis. (bjcvs.org)
  • Calcific aortic valve disease is relatively common in the high-income countries, affecting between 4% and 5% of adults above the age of 75 years, and unless corrected, it carries significant morbidity and mortality. (bmj.com)
  • The third presentation-the most common presentation-occurs because of calcific degeneration of an otherwise normal trileaflet aortic valve and typically presents in the seventh or eighth decade of life. (jaoa.org)
  • Medtronic Open Pivot™ mechanical heart valves bring something fundamentally different to bileaflet valve design. (medtronic.com)
  • Endothelial pannus and thrombus formation which usually deposit on bileaflet mechanical heart valves progressively lead to incomplete opening of the valve. (unipd.it)
  • Bileaflet mechanical valves are considered good long-term substitutes, but are still undergoing improvements. (biomedcentral.com)
  • An in vitro test campaign of flow through a bileaflet mechanical heart valve (Sorin Slimline 25 mm) was performed in a suitably arranged pulsatile mock loop able to reproduce human systemic pressure and flow curves. (biomedcentral.com)
  • problems have plagued the most common form of MHVs, bileaflet mechanical heart valves (BMHVs), for decades as their designs have stagnated. (vivitrolabs.com)
  • My Ph.D. research work was about CFD and sound analysis of a bileaflet mechanical heart valve. (siemens.com)
  • So for your dissertation, you worked on a bileaflet mechanical heart valve model, right? (siemens.com)
  • At Leeds Ionescu designed, created and implanted in the mitral position in humans, for the first time ever, porcine aortic valves attached to a Teflon cloth collar, starting in February 1967. (wikipedia.org)
  • The control case that corresponds to the aortic root of a patient without valve disease was used as a reference. (asme.org)
  • Chopra told MD+DI that the overall pool of patients needing a new heart valve continues to grow, in part because the transcatheter valve market has increased awareness of structural heart disease. (mddionline.com)
  • Aortic valve disease is one of the most common valvular heart diseases in the cardiovascular category. (bjcvs.org)
  • and 3) rheumatic heart valve disease. (bjcvs.org)
  • Clinically, 99 patients could be evaluated at follow-up one year following surgery: two patients were excluded due to valve size 27 mm, there were two early and three late deaths, two patients developed Hodgkin's disease and there were missing data in four patients. (biomedcentral.com)
  • About half of the cases of AI are due to the aortic root dilatation, which is idiopathic in more than 80% of cases, but may result from aging, syphilitic aortitis, osteogenesis imperfecta, aortic dissection, Behçet's disease, reactive arthritis and systemic hypertension. (renalandurologynews.com)
  • Lancellotti P, Magne J: Stress echocardiography in regurgitant valve disease. (wjcmpr.com)
  • Pierard LA, Lancellotti P: Stress testing in valve disease. (wjcmpr.com)
  • Nishimura RA, Otto CM, Bonow RO, et al: 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines. (wjcmpr.com)
  • Vahanian A, Alfieri O, Andreotti F, et al: Guidelines on the management of valvular heart disease (version 2012). (wjcmpr.com)
  • The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio- Thoracic Surgery (EACTS) (in Italian). (wjcmpr.com)
  • The bicuspid aortic valve, a kind of heart disease that comes from parents, has been paid attention around the world. (frontiersin.org)
  • Bicuspid aortic valve (BAV) disease has the characteristic of heredity with variable genetic penetrance. (frontiersin.org)
  • Find out more about your heart valves and how to manage heart valve disease. (heart.org)
  • This study introduces a cardiovascular modelling system (CMS) which may detect possible disease conditions and facilitate early diagnosis prior to heart failure, using hybrid CFD simulation and time-resolved magnetic resonance imaging (MRI). (biomedcentral.com)
  • As the disease worsens, these compensatory mechanisms become inadequate, leading to symptoms of heart failure, angina, or syncope. (aafp.org)
  • The prosthetic valves available to treat heart valve disease are poorly suited for younger and more active patients. (butcherlab.com)
  • The prevalence of valvular heart disease in the United States is estimated to be about 2.5% and increases in prevalence with age. (emdocs.net)
  • 1 Though patients with clinically evident valvular heart disease have a 3.2-fold increase risk for stroke and 2.5-fold increase risk for death, 2 most valvular heart disease encountered in the emergency department is chronic and does not require emergency stabilization. (emdocs.net)
  • A new diagnostic procedure for assessing intracardiac flow disturbances in patients with heart valve disease. (uni-heidelberg.de)
  • New perspectives of the disease now lead us to see the condition in terms of the response of the left ventricle and of systemic features, rather than just in terms of the valve area itself. (jaoa.org)
  • The incidence of rheumatic heart disease has dropped so much in North America that, in my experience, rheumatic AS is rarely seen. (jaoa.org)
  • Patients with aortic valve disease may need to have valve surgery if it becomes too tight or leaks too much. (cardiachealth.org)
  • With one of the largest structural heart device portfolios today, Abbott management is committed to advancing its product pipeline through new life-changing technologies and therapies that improve how structural heart disease is treated. (abbott.com)
  • ACC/AHA guidelines for the management of patients with valvular heart disease. (who.int)
  • In his continuous search for the 'Holy Grail', Ionescu experimented with valves made from bovine pericardium (the membrane which surrounds the heart) treated with glutaraldehyde and mounted on a Dacron covered titanium frame. (wikipedia.org)
  • He created this artificial bioprosthetic heart valve as a three-cusp structure made of chemically treated bovine pericardium attached to a Dacron cloth-covered titanium frame. (wikipedia.org)
  • The Edwards SAPIEN valve consists of trileaflet bovine-pericardium valve mounted on a balloon-expandable stainless steel stent, and is available in four sizes (20, 23, 26 and 29 mm). (bmj.com)
  • Stress DSI data, least reliant on variable annulus/valve sizes and flow rates, provided the best haemodynamic discrimination. (bmj.com)
  • TAVI may provide a reasonable alternative to conventional AVR in elderly patients with a small aortic annulus. (onlinejacc.org)
  • Radial pressure of the stent frame should ensure a safe contact between the device and the debrided aortic annulus with no requirement for pledget-armed sutures. (springer.com)
  • This work shows the design and implementation of a 3D-printed valve dilation device to preferentially dilate the posterior mitral valve annulus. (vivitrolabs.com)
  • Some 10 years after the creation of the pericardial valve by Ionescu, and its use by numerous surgeons and after having demonstrated its excellent haemodynamic performance and the reduced propensity for thrombo-embolism, other companies began manufacturing and distributing a plethora of rather similar pericardial valves. (wikipedia.org)
  • Approximately 200,000 pericardial valves manufactured by Shiley Laboratories were distributed around the world between 1976 and 1987 and it is presumed that most of them were implanted in patients. (wikipedia.org)
  • The durability of present generation pericardial valves and homografts are very similar. (cardiachealth.org)
  • The objective of this review article is to assess the current evidence behind using bioprosthetic aortic valve in this young cohort. (bjcvs.org)
  • A homograft is an aortic or pulmonic valve that has been removed from a donated human heart, preserved, antibiotic-treated, and frozen under sterile conditions. (cardiachealth.org)
  • A homograft may be used to replace a diseased aortic valve, or it may be used to replace the pulmonic valve during the Ross procedure. (cardiachealth.org)
  • By varying the aortic root geometry, while keeping the diameter of the orifice constant, it was possible to investigate corresponding changes in the levels of Reynolds shear stress and establish the possibility of platelet activation and, as a result of that, the formation of blood clots. (asme.org)
  • The geometry of the valve was slightly modified due to changes in the shape of the stent and by removing the outside plegets around the posts. (wikipedia.org)
  • The aortic geometry is obtained from a series of cine-MR images and reconstructed using Mimics software. (asme.org)
  • The heart valve geometry was modeled based on St. Jude Regent Medical heart valve. (siemens.com)
  • In addition, we used a realistic geometry of the aortic sinuses, since it is important for appropriate flow field analysis. (siemens.com)
  • Haemodynamic differences, however, did not translate into differences in left ventricular mass reduction at 1 year. (bmj.com)
  • The groups had no differences in the aortic valve mean pressure gradient (AVMPG) or the left ventricular mass index (LVMI) at 5 years after surgery. (kjtcvs.org)
  • Fluid-structure interaction (FSI) models were utilized and the valves' hemodynamics, flexural stresses, strains, orifice area, and wall shear stresses (WSS) were compared. (asme.org)
  • The numerical methodology presented can be further used as a predictive tool for valve design optimization for enhanced hemodynamics and durability. (asme.org)
  • This original valve, designed and created by Ionescu, demonstrated excellent hydrodynamic performance with good durability during in-vitro fatigue testing. (wikipedia.org)
  • Surprisingly, this study defines a distinct proteome for each semilunar valve. (nih.gov)
  • The commissural tabs provide commissural attachment points to accommodate sutures and the like in order to secure the tab to a vessel wall, if a semilunar valve, and papillary muscles and/or chordae tendineae if an atrioventricular valve. (justia.com)
  • 112 patients who received small and medium sized St.Jude Regent heart valves (19-25 mm) at 7 Scandinavian centers were studied between January 2003 and February 2005 to obtain non-invasive data regarding the hemodynamic performance at rest and during Dobutamine stress echocardiography (DSE) testing one year after surgery. (biomedcentral.com)
  • To assess the resting echo profile of patients with prosthetic mitral valve and monitor the function of the prosthetic valves by doing stress echocardiography by treadmill exercise and dobutamine infusion. (wjcmpr.com)
  • To be able to monitor dynamic changes in the heart function and haemodynamics, a bicycle bench has been developed, on which the patient is placed in a semi-supine, tilted position, allowing for echocardiography to be undertaken simultaneously with the stress (ergonomic stress echocardiography) (Figure 1). (tidsskriftet.no)
  • Low EF usually indicates systolic dysfunction and severe heart failure can result in EF lower than 0.2. (wikidoc.org)
  • Furthermore, the study investigated the hemodynamic response to dobutamine stress related to the size of normally functioning valves. (biomedcentral.com)
  • From 1976 onwards a series of modifications were made in order to improve the qualities and the performance of the pericardial xenograft. (wikipedia.org)
  • These modifications had been progressively introduced and all of them were incorporated in the 'Ionescu - Shiley Low Profile Pericardial Xenograft' valve, which became available in 1983. (wikipedia.org)
  • The Carpentier-Edwards Perimount Magna aortic xenograft: a new design with an improved hemodynamic performance. (edwards.com)
  • Exercise Doppler echocardiography in patients with mitral prosthetic valves. (wjcmpr.com)
  • He reportedly had normal systolic left heart function in the presence of left ventricular endocardial fibroelastosis (EFE) without signs of elevated right ventricular pressure on echocardiography. (hindawi.com)
  • Echocardiography: 4-chamber view showing extremely enlarged left atrium (LA) and endocardial fibroelastosis (arrows) of left ventricle (LV) and mitral valve apparatus (a). (hindawi.com)
  • Pulsed Doppler echocardiography in the diagnosis and estimation of severity of aortic insufficiensy. (who.int)
  • As a valve calcifies it also becomes increasingly stenotic. (vivitrolabs.com)
  • Younger patients usually only have features of a leaking rather than a stenotic valve. (cardiachealth.org)
  • Aortic valve repair is only an option for leaky aortic valves, not stenotic valves. (cardiachealth.org)