A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, infecting a variety of vertebrates including humans. Parvoviruses are responsible for a number of important diseases but also can be non-pathogenic in certain hosts. The type species is MINUTE VIRUS OF MICE.
The type species of ERYTHROVIRUS and the etiological agent of ERYTHEMA INFECTIOSUM, a disease most commonly seen in school-age children.
Virus infections caused by the PARVOVIRIDAE.
A species of the genus PARVOVIRUS and a host range variant of FELINE PANLEUKOPENIA VIRUS. It causes a highly infectious fulminating ENTERITIS in dogs producing high mortality. It is distinct from CANINE MINUTE VIRUS, a species in the genus BOCAVIRUS. This virus can also infect cats and mink.
A family of very small DNA viruses containing a single molecule of single-stranded DNA and consisting of two subfamilies: PARVOVIRINAE and DENSOVIRINAE. They infect both vertebrates and invertebrates.
A species of PARVOVIRUS causing reproductive failure in pigs.
Contagious infection with human B19 Parvovirus most commonly seen in school age children and characterized by fever, headache, and rashes of the face, trunk, and extremities. It is often confused with rubella.
A species in the genus PARVOVIRUS that has the ability to replicate and kill tumor cells in culture.
The type species of PARVOVIRUS prevalent in mouse colonies and found as a contaminant of many transplanted tumors or leukemias.
A species of PARVOVIRUS infecting cats with a highly contagious enteric disease. Host range variants include mink enteritis virus, canine parvovirus (PARVOVIRUS, CANINE), and raccoon parvovirus. After infecting their new hosts, many of these viruses have further evolved and are now considered distinct species.
A species of PARVOVIRUS that causes a disease in mink, mainly those homozygous for the recessive Aleutian gene which determines a desirable coat color.
Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, and containing the type species PARVOVIRUS B19, HUMAN.
Deoxyribonucleic acid that makes up the genetic material of viruses.
A highly contagious DNA virus infection of the cat family, characterized by fever, enteritis and bone marrow changes. It is also called feline ataxia, feline agranulocytosis, feline infectious enteritis, cat fever, cat plague, and show fever. It is caused by FELINE PANLEUKOPENIA VIRUS or the closely related MINK ENTERITIS VIRUS or CANINE PARVOVIRUS.
A slow progressive disease of mink caused by the ALEUTIAN MINK DISEASE VIRUS. It is characterized by poor reproduction, weight loss, autoimmunity, hypergammaglobulinemia, increased susceptibility to bacterial infections, and death from renal failure. The disease occurs in all color types, but mink which are homozygous recessive for the Aleutian gene for light coat color are particularly susceptible.
Proteins that form the CAPSID of VIRUSES.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
Carnivores of genus Mustela of the family MUSTELIDAE. The European mink, which has white upper and lower lips, was widely trapped for commercial purposes and is classified as endangered. The American mink, lacking a white upper lip, is farmed commercially.
Species of the genus MASTADENOVIRUS that causes fever, edema, vomiting, and diarrhea in dogs and encephalitis in foxes. Epizootics have also been caused in bears, wolves, coyotes, and skunks. The official species name is Canine adenovirus and it contains two serotypes.
A genus in the subfamily PARVOVIRINAE comprising three species: Bovine parvovirus, Canine minute virus, and HUMAN BOCAVIRUS.
A subfamily of DNA arthropod viruses, in the family PARVOVIRIDAE. The host range includes members of Dictyoptera; DIPTERA; LEPIDOPTERA; Odonata; and ORTHOPTERA. There are three genera: DENSOVIRUS, Iteravirus, and Brevidensovirus. Densovirus-like viruses also infect and multiply in crabs and shrimp.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).
A member of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, originally isolated from human nasopharyngeal aspirates in patients with respiratory disease.
A mammalian fetus expelled by INDUCED ABORTION or SPONTANEOUS ABORTION.
I'm sorry for any confusion, but the term "geese" is a common name for certain species of waterfowl and doesn't have a medical definition. It is not related to medical terminology or healthcare.
A genus of PARVOVIRIDAE, subfamily DENSOVIRINAE, comprising helper-independent viruses containing only two species. Junonia coenia densovirus is the type species.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Established cell cultures that have the potential to propagate indefinitely.
Anemia characterized by appearance of immature myeloid and nucleated erythrocytes in the peripheral blood, resulting from infiltration of the bone marrow by foreign or abnormal tissue.
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
A blood group related to the ABO, Lewis and I systems. At least five different erythrocyte antigens are possible, some very rare, others almost universal. Multiple alleles are involved in this blood group.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
Substances elaborated by viruses that have antigenic activity.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.
Any of several carnivores in the family CANIDAE, that possess erect ears and long bushy tails and are smaller than WOLVES. They are classified in several genera and found on all continents except Antarctica.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
The process by which a DNA molecule is duplicated.
An order of MAMMALS, usually flesh eaters with appropriate dentition. Suborders include the terrestrial carnivores Fissipedia, and the aquatic carnivores PINNIPEDIA.
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production.
The relationships of groups of organisms as reflected by their genetic makeup.
In utero transfusion of BLOOD into the FETUS for the treatment of FETAL DISEASES, such as fetal erythroblastosis (ERYTHROBLASTOSIS, FETAL).
A species of VARICELLOVIRUS virus that causes a disease in newborn puppies.
Proteins found in any species of virus.
A general term for diseases produced by viruses.
A species of the genus PARVOVIRUS and a host range variant of FELINE PANLEUKOPENIA VIRUS. It causes a highly contagious inflammatory gastroenteritis (MINK VIRAL ENTERITIS). In addition to mink, this virus can also infect cats and dogs.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
The functional hereditary units of VIRUSES.
The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.
A primitive form of digestive gland found in marine ARTHROPODS, that contains cells similar to those found in the mammalian liver (HEPATOCYTES), and the PANCREAS.
Virus diseases caused by the CIRCOVIRIDAE.
Agglutination of ERYTHROCYTES by a virus.
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
Diseases of domestic swine and of the wild boar of the genus Sus.
A genus of the family CIRCOVIRIDAE that infects SWINE; PSITTACINES; and non-psittacine BIRDS. Species include Beak and feather disease virus causing a fatal disease in psittacine birds, and Porcine circovirus causing postweaning multisystemic wasting syndrome in pigs (PORCINE POSTWEANING MULTISYSTEMIC WASTING SYNDROME).
A family of CRUSTACEA, order DECAPODA, comprising the penaeid shrimp. Species of the genus Penaeus are the most important commercial shrimp throughout the world.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Carnivores of the genus Procyon of the family PROCYONIDAE. Two subgenera and seven species are currently recognized. They range from southern Canada to Panama and are found in several of the Caribbean Islands.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.
The largest order of CRUSTACEA, comprising over 10,000 species. They are characterized by three pairs of thoracic appendages modified as maxillipeds, and five pairs of thoracic legs. The order includes the familiar shrimps, crayfish (ASTACOIDEA), true crabs (BRACHYURA), and lobsters (NEPHROPIDAE and PALINURIDAE), among others.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A genus in the family of EARLESS SEALS (Phocidae) and collectively the most abundant PINNIPEDS in the Northern Hemisphere.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells. (1/18)

Gliomas are often resistant to the induction of apoptotic cell death as a result of the development of survival mechanisms during astrocyte malignant transformation. In particular, the overexpression of Bcl-2-family members interferes with apoptosis initiation by DNA-damaging agents (e.g., cisplatin) or soluble death ligands (e.g., TRAIL). Using low-passage-number cultures of glioma cells, we have shown that parvovirus H-1 is able to induce death in cells resistant to TRAIL, cisplatin, or both, even when Bcl-2 is overexpressed. Parvovirus H-1 triggers cell death through both the accumulation of lysosomal cathepsins B and L in the cytosol of infected cells and the reduction of the levels of cystatin B and C, two cathepsin inhibitors. The impairment of either of these effects protects glioma cells from the viral lytic effect. In normal human astrocytes, parvovirus H-1 fails to induce a killing mechanism. In vivo, parvovirus H-1 infection of rat glioma cells intracranially implanted into recipient animals triggers cathepsin B activation as well. This report identifies for the first time cellular effectors of the killing activity of parvovirus H-1 against malignant brain cells and opens up a therapeutic approach which circumvents their frequent resistance to other death inducers.  (+info)

Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein. (2/18)

AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cytotoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Furthermore, H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis, the cytotoxicity of H-1 PV was more pronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses, H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition, H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents, and it enhances the apoptotic process which is dependent on functional PML. Thus, H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC, particularly for p53-negative tumors.  (+info)

Improved killing of human high-grade glioma cells by combining ionizing radiation with oncolytic parvovirus H-1 infection. (3/18)

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Regression of advanced rat and human gliomas by local or systemic treatment with oncolytic parvovirus H-1 in rat models. (4/18)

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Through its nonstructural protein NS1, parvovirus H-1 induces apoptosis via accumulation of reactive oxygen species. (5/18)

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Immune cells participate in the oncosuppressive activity of parvovirus H-1PV and are activated as a result of their abortive infection with this agent. (6/18)

Treatment of cancers by means of viruses, that specifically replicate in (oncotropism) and kill (oncolysis) neoplastic cells, is increasingly gaining acceptance in the clinic. Among these agents, parvoviruses have been shown to possess not only direct oncolytic but also immunomodulating properties, serving as an adjuvant to prime the immune system to react against infected tumors. Here, we aimed to establish whether immunomodulating mechanisms participate in the recently reported therapeutic potential of parvoviruses against pancreatic carcinoma. Using adoptive transfer experiments we discovered that the transfer of splenocytes of donor rats harboring H-1PV-treated orthotopic PDAC tumors could significantly prolong the survival of naive tumor-bearing recipients, compared to those receiving cells from mock-treated donors. Closer investigation of immunological parameters in infected donor rats revealed that virus-induced interferon gamma production and cellular immune response played an important role in this effect. These data have also preclinical relevance since abortive H-1PV infection of human peripheral blood mononuclear cells or cocultivation of these cells with H-1PV-preinfected pancreatic cancer cells, resulted in enhancement of innate and adaptive immune reactivity. Taken together our data reveal that oncolytic H-1PV modulates the immune system into an anticancer state, and further support the concept of using parvoviruses in the fight against pancreatic cancer.  (+info)

Therapeutic implications of the enhanced short and long-term cytotoxicity of radiation treatment followed by oncolytic parvovirus H-1 infection in high-grade glioma cells. (7/18)

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Regression of glioma in rat models by intranasal application of parvovirus h-1. (8/18)

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Parvovirus is a type of virus that is known to cause diseases in various animals, including dogs and humans. The most common strain that infects humans is called Parvovirus B19. This particular strain is responsible for the illness known as Fifth disease, which primarily affects young children and causes symptoms such as fever, rash, and joint pain.

Parvovirus B19 spreads through respiratory droplets, such as when an infected person coughs or sneezes. It can also be transmitted through blood or contaminated objects. Once the virus enters the body, it typically targets and infects rapidly dividing cells, particularly those found in the bone marrow and the fetal heart.

In dogs, a different strain of parvovirus called Canine Parvovirus (CPV) is responsible for a highly contagious and often fatal gastrointestinal illness. CPV primarily affects puppies between 6 weeks and 6 months old, but older dogs can also be infected if they haven't been vaccinated.

It is essential to maintain good hygiene practices and ensure proper vaccination to prevent parvovirus infections in both humans and animals.

Parvovirus B19, Human is a single-stranded DNA virus that primarily infects humans. It belongs to the Parvoviridae family and Erbovirus genus. This virus is the causative agent of erythema infectiosum, also known as fifth disease, a mild, self-limiting illness characterized by a facial rash and occasionally joint pain or inflammation.

Parvovirus B19 has a strong tropism for erythroid progenitor cells in the bone marrow, where it replicates and causes temporary suppression of red blood cell production (aplastic crisis) in individuals with underlying hemolytic disorders such as sickle cell disease or spherocytosis.

Additionally, Parvovirus B19 can cause more severe complications in immunocompromised individuals, pregnant women, and fetuses. Infection during pregnancy may lead to hydrops fetalis, anemia, or even fetal death, particularly in the first and second trimesters. Transmission of the virus occurs primarily through respiratory droplets and occasionally via blood transfusions or vertical transmission from mother to fetus.

Parvoviridae infections refer to diseases caused by viruses belonging to the Parvoviridae family. These viruses are known to infect a wide range of hosts, including humans, animals, and insects. The most well-known member of this family is the human parvovirus B19, which is responsible for a variety of clinical manifestations such as:

1. Erythema infectiosum (Fifth disease): A common childhood exanthem characterized by a "slapped cheek" rash and a lace-like rash on the extremities.
2. Transient aplastic crisis: A sudden and temporary halt in red blood cell production, which can lead to severe anemia in individuals with underlying hematologic disorders.
3. Hydrops fetalis: Intrauterine death due to severe anemia caused by parvovirus B19 infection in pregnant women, leading to heart failure and widespread fluid accumulation in the fetus.

Parvoviruses are small, non-enveloped viruses with a single-stranded DNA genome. They primarily infect and replicate within actively dividing cells, making them particularly harmful to rapidly proliferating tissues such as bone marrow and fetal tissues. In addition to parvovirus B19, other Parvoviridae family members can cause significant diseases in animals, including cats, dogs, and livestock.

Canine Parvovirus (CPV) is a small, non-enveloped, single-stranded DNA virus that belongs to the family Parvoviridae and genus Parvovirus. It is highly contagious and can cause severe gastrointestinal illness in dogs, particularly in puppies between 6 weeks and 6 months old.

The virus primarily attacks rapidly dividing cells in the body, such as those found in the intestinal lining, leading to symptoms like vomiting, diarrhea (often bloody), lethargy, loss of appetite, and fever. CPV can also cause damage to the bone marrow, which can result in a decrease in white blood cell counts and make the dog more susceptible to secondary infections.

Canine parvovirus is highly resistant to environmental factors and can survive for long periods of time on surfaces, making it easy to transmit from one dog to another through direct contact with infected dogs or their feces. Fortunately, there are effective vaccines available to prevent CPV infection in dogs.

Parvoviridae is a family of small, non-enveloped viruses that infect a wide range of hosts, including humans, animals, and birds. These viruses have a single-stranded DNA genome and replicate in the nucleus of infected cells. They are resistant to heat, acid, and organic solvents, making them difficult to inactivate.

The family Parvoviridae is divided into two subfamilies: Parvovirinae and Densovirinae. Parvovirinae infect vertebrates, while Densovirinae infect invertebrates. The subfamily Parvovirinae includes several genera that infect various hosts, such as humans, dogs, cats, and primates.

Parvovirus B19 is a well-known member of this family that causes a variety of clinical manifestations in humans, including fifth disease (slapped cheek syndrome), arthralgia, and occasionally more severe diseases in immunocompromised individuals or those with certain hematological disorders.

In animals, parvoviruses can cause serious diseases such as canine parvovirus infection in dogs and feline panleukopenia in cats, which can be fatal if left untreated.

Parvovirus, Porcine (PPV) is a single-stranded DNA virus that belongs to the family Parvoviridae and genus Parvovirus. It is a small, non-enveloped virus that primarily infects the rapidly dividing cells of piglets, particularly those in the intestinal epithelium and bone marrow.

PPV infection can cause a variety of clinical signs, including diarrhea, vomiting, lethargy, and loss of appetite, which can lead to severe dehydration and death in young piglets. The virus is highly contagious and can be spread through fecal-oral transmission or by ingesting infected material.

PPV infection is also associated with reproductive failure in sows, including stillbirths, mummified fetuses, and weak newborn piglets. This condition is known as Porcine Parvovirus Syndrome (PPVS). The virus can cross the placenta and infect developing fetuses, causing damage to their cardiovascular and nervous systems.

There are currently no specific treatments for PPV infection, but vaccination programs have been developed to prevent the spread of the virus in pig herds. Good biosecurity practices, such as isolating infected animals and thoroughly cleaning and disinfecting facilities, can also help reduce the risk of transmission.

Erythema infectiosum is a viral infection commonly known as "fifth disease." It is caused by the human parvovirus B19 and primarily affects children. The characteristic symptom of erythema infectiosum is a distinctive red rash on the cheeks, which gives the appearance of having been slapped, hence one of its other names, "slapped cheek syndrome." After a few days, the rash may spread to the arms, legs, and trunk, often in a lacy or net-like pattern. The rash is usually not itchy or painful.

In addition to the rash, people with erythema infectiosum may experience mild flu-like symptoms such as fever, headache, and fatigue. Some individuals may also develop joint pain and swelling, particularly adolescents and adults. In most cases, erythema infectiosum is a self-limiting illness that resolves within one to three weeks without specific treatment. However, the rash may come and go for several weeks, especially when exposed to sunlight, heat, or emotional stress.

Erythema infectiosum is usually spread through respiratory droplets when an infected person coughs or sneezes. It can also be transmitted through blood transfusions and from mother to fetus during pregnancy. While most cases of erythema infectiosum are mild, the infection can cause more severe complications in people with weakened immune systems, sickle cell disease, or chronic hemolytic anemia. Pregnant women who contract erythema infectiosum may have a higher risk of miscarriage, stillbirth, or premature delivery, especially during the first half of pregnancy.

H-1 parvovirus is not typically used as a medical term. However, Parvovirus H-1 is a species of parvovirus that primarily infects canines and is not known to infect humans. It is associated with myocarditis (inflammation of the heart muscle) in dogs. Therefore, it's important to clarify that H-1 parvovirus is not related to human Parvovirus B19, which is a more common type of parvovirus that can cause disease in humans.

The Minute Virus of Mice (MVM) is a small, single-stranded DNA parvovirus that primarily infects laboratory mice. It was so named because of its extremely small size and the minimal cytopathic effect it causes in infected cells. MVM is not known to cause disease in humans or other animals. However, it has been used as a model system for studying parvovirus biology and pathogenesis due to its ability to efficiently infect and replicate in many types of mammalian cells. There are three strains of MVM (MVMp, MVMi, and MVMc) that vary in their host range and tissue tropism.

Feline panleukopenia virus (FPV) is a highly contagious and deadly viral disease that primarily affects domestic cats, as well as other members of the Felidae family. It is also known as feline parvovirus or feline distemper. The virus attacks the rapidly dividing cells in the body, including those found in the intestines, bone marrow, and fetus.

The primary mode of transmission of FPV is through direct contact with infected cats or their feces. The virus can also be spread indirectly through contaminated objects such as clothing, food bowls, and litter boxes. FPV is resistant to many disinfectants and can survive in the environment for long periods, making it a challenging disease to control.

The symptoms of FPV include severe vomiting, diarrhea (often containing blood), loss of appetite, high fever, lethargy, and sudden death. The virus can also cause abortion in pregnant cats. Diagnosis is typically made based on clinical signs and laboratory tests that detect the presence of the virus in feces or other bodily fluids.

Treatment for FPV is primarily supportive, as there are no antiviral medications available to treat the disease. Treatment may include fluid therapy, nutritional support, antibiotics to prevent secondary bacterial infections, and medication to control vomiting and diarrhea. The prognosis for cats with FPV is guarded, and many die despite aggressive treatment.

Prevention of FPV is through vaccination, which is recommended for all cats. Kittens should receive their first FPV vaccine at 6-8 weeks of age, followed by boosters every 3-4 weeks until they are 16-20 weeks old. Adult cats should be vaccinated annually or as recommended by a veterinarian. It is also important to practice good hygiene and sanitation to prevent the spread of FPV in multi-cat households or shelters.

Aleutian Mink Disease Virus (AMDV) is a small, single-stranded, negative-sense RNA virus belonging to the family Parvoviridae and genus Amdoparvovirus. This virus primarily infects minks, causing a chronic wasting disease known as Aleutian Disease. The name of the virus comes from the Aleutian Islands of Alaska where the disease was first identified in mink farms during the 1940s.

The virus is highly host-specific and does not typically infect humans or other animals, except for some cases in wild and farmed foxes, raccoons, and dogs. The infection in these animals may lead to similar symptoms as observed in minks, such as weight loss, anemia, and immune suppression.

AMDV has a strong affinity for infecting cells of the monocyte-macrophage lineage, leading to chronic inflammation and immune complex deposition in various organs, including the kidneys, spleen, and liver. The infection can result in a spectrum of clinical signs, from subclinical to severe and fatal disease, depending on factors such as the age, genetics, and immune status of the host.

Diagnosis of AMDV infection is usually accomplished through serological tests, such as ELISA or hemagglutination inhibition assays, which detect antibodies against the virus in infected animals. Additionally, molecular techniques like PCR can be used to directly amplify and detect viral DNA in clinical samples.

There are no specific treatments for AMDV infection, and control measures primarily focus on preventing the spread of the virus through biosecurity practices, such as maintaining strict sanitation, quarantine procedures, and vaccination programs for susceptible animals.

Hydrops Fetalis is a serious condition characterized by the accumulation of excessive fluid in two or more fetal compartments, including the abdomen (ascites), around the heart (pericardial effusion), and/or within the lungs (pleural effusion). This accumulation can also affect the skin, causing it to become edematous. Hydrops Fetalis is often associated with various underlying causes, such as chromosomal abnormalities, congenital infections, genetic disorders, and structural defects that impair the fetus's ability to maintain fluid balance. In some cases, the cause may remain unknown. The prognosis for Hydrops Fetalis is generally poor, with a high mortality rate, although early detection and appropriate management can improve outcomes in certain situations.

Erythrovirus is a genus of viruses in the family *Polyomaviridae*. This genus includes several human viruses that were previously known as human mastadenoviruses. They are non-enveloped, double-stranded DNA viruses that primarily infect erythroid cells, hence the name Erythrovirus.

The most well-known member of this genus is Human parvovirus B19 (B19V), which is a human pathogen that causes several clinical manifestations, such as Fifth disease, aplastic crisis, and hydrops fetalis. The infection with B19V is usually self-limiting in healthy individuals; however, it can cause severe complications in immunocompromised patients or those with certain hematological disorders.

Other members of the Erythrovirus genus include Primate erythrovirus 1 (PEV-1) and Primate erythrovirus 2 (PEV-2), which have been identified in non-human primates. These viruses share genetic similarities with B19V, but their clinical significance remains unclear.

In summary, Erythrovirus is a genus of viruses that primarily infect erythroid cells and include several human pathogens, such as Human parvovirus B19, which can cause various clinical manifestations in humans.

Viral DNA refers to the genetic material present in viruses that consist of DNA as their core component. Deoxyribonucleic acid (DNA) is one of the two types of nucleic acids that are responsible for storing and transmitting genetic information in living organisms. Viruses are infectious agents much smaller than bacteria that can only replicate inside the cells of other organisms, called hosts.

Viral DNA can be double-stranded (dsDNA) or single-stranded (ssDNA), depending on the type of virus. Double-stranded DNA viruses have a genome made up of two complementary strands of DNA, while single-stranded DNA viruses contain only one strand of DNA.

Examples of dsDNA viruses include Adenoviruses, Herpesviruses, and Poxviruses, while ssDNA viruses include Parvoviruses and Circoviruses. Viral DNA plays a crucial role in the replication cycle of the virus, encoding for various proteins necessary for its multiplication and survival within the host cell.

Feline Panleukopenia is a highly contagious and often fatal viral disease in cats, also known as feline parvovirus infection. It is caused by the feline parvovirus (FPV), which belongs to the same family as the canine parvovirus. The virus primarily affects the rapidly dividing cells in the cat's body, such as those found in the intestinal lining, bone marrow, and fetal tissues.

The term "panleukopenia" refers to the severe decrease in white blood cells (leukopenia) that occurs in infected cats. This profound immune suppression makes the cat highly susceptible to secondary bacterial and viral infections, further complicating its condition.

Clinical signs of Feline Panleukopenia may include:

1. Vomiting
2. Diarrhea (often containing blood)
3. Loss of appetite
4. Lethargy
5. High fever
6. Abdominal pain
7. Dehydration

The virus is transmitted through direct contact with infected cats or their feces, as well as contaminated environments, food, and water bowls. Feline Panleukopenia can be prevented through vaccination, which is a critical component of routine cat healthcare. If you suspect your cat may have contracted this virus, consult a veterinarian immediately for appropriate diagnosis and treatment.

Aleutian Mink Disease (AMD) is a viral disease that primarily affects minks, particularly those of the Aleutian subspecies. The disease is caused by the parvovirus known as the Aleutian mink disease virus (ADMV).

The virus targets and infects the immune system's white blood cells, leading to a hyperactive immune response. This results in the production of excessive amounts of antibodies, a condition known as "autoimmune disease." The continued stimulation of the immune system can lead to damage and failure of various organs, including the liver and kidneys.

Clinical signs of AMD can vary widely but often include weight loss, anemia, jaundice, and neurological symptoms such as uncoordinated movements and tremors. The disease can be spread through direct contact with infected animals or their bodily fluids, as well as through contaminated equipment or surfaces.

It's worth noting that while the Aleutian Mink Disease primarily affects minks, there have been reports of related parvoviruses infecting other animal species, including humans. However, these viruses are not considered to be a significant public health concern at this time.

Capsid proteins are the structural proteins that make up the capsid, which is the protective shell of a virus. The capsid encloses the viral genome and helps to protect it from degradation and detection by the host's immune system. Capsid proteins are typically arranged in a symmetrical pattern and can self-assemble into the capsid structure when exposed to the viral genome.

The specific arrangement and composition of capsid proteins vary between different types of viruses, and they play important roles in the virus's life cycle, including recognition and binding to host cells, entry into the cell, and release of the viral genome into the host cytoplasm. Capsid proteins can also serve as targets for antiviral therapies and vaccines.

A capsid is the protein shell that encloses and protects the genetic material of a virus. It is composed of multiple copies of one or more proteins that are arranged in a specific structure, which can vary in shape and symmetry depending on the type of virus. The capsid plays a crucial role in the viral life cycle, including protecting the viral genome from host cell defenses, mediating attachment to and entry into host cells, and assisting with the assembly of new virus particles during replication.

Antibodies, viral are proteins produced by the immune system in response to an infection with a virus. These antibodies are capable of recognizing and binding to specific antigens on the surface of the virus, which helps to neutralize or destroy the virus and prevent its replication. Once produced, these antibodies can provide immunity against future infections with the same virus.

Viral antibodies are typically composed of four polypeptide chains - two heavy chains and two light chains - that are held together by disulfide bonds. The binding site for the antigen is located at the tip of the Y-shaped structure, formed by the variable regions of the heavy and light chains.

There are five classes of antibodies in humans: IgA, IgD, IgE, IgG, and IgM. Each class has a different function and is distributed differently throughout the body. For example, IgG is the most common type of antibody found in the bloodstream and provides long-term immunity against viruses, while IgA is found primarily in mucous membranes and helps to protect against respiratory and gastrointestinal infections.

In addition to their role in the immune response, viral antibodies can also be used as diagnostic tools to detect the presence of a specific virus in a patient's blood or other bodily fluids.

Viral nonstructural proteins (NS) are viral proteins that are not part of the virion structure. They play various roles in the viral life cycle, such as replication of the viral genome, transcription, translation regulation, and modulation of the host cell environment to favor virus replication. These proteins are often produced in large quantities during infection and can manipulate or disrupt various cellular pathways to benefit the virus. They may also be involved in evasion of the host's immune response. The specific functions of viral nonstructural proteins vary depending on the type of virus.

I'm sorry for any confusion, but "Mink" is not a medical term. It refers to a species of small, semiaquatic carnivorous mammals that are known for their sleek fur. They belong to the family Mustelidae, which also includes otters, weasels, and ferrets. If you have any questions about medical terminology or health-related topics, I'd be happy to help!

Canine adenoviruses are a type of virus that can infect dogs and cause two distinct diseases: Infectious Canine Hepatitis (type 1) and Canine Respiratory Disease Complex (type 2).

Canine adenovirus type 1 primarily affects the liver, causing symptoms such as vomiting, diarrhea, loss of appetite, and abdominal pain. In severe cases, it can lead to liver failure and death.

Canine adenovirus type 2 mainly causes respiratory infections, including kennel cough, which is characterized by a harsh, hacking cough and nasal discharge. It can also cause pneumonia in some cases.

Both types of canine adenoviruses are highly contagious and can be spread through direct contact with infected dogs or their feces and urine. Vaccination is available to protect against both forms of the virus and is recommended for all dogs.

Bocavirus is a type of virus that belongs to the Parvoviridae family. It is specifically classified under the genus Bocaparvovirus. This virus is known to infect humans and animals, causing respiratory and gastrointestinal illnesses. In humans, human bocavirus (HBoV) has been identified as a cause of acute respiratory tract infections, particularly in young children. There are four species of HBoV (HBoV1-4), but HBoV1 is the most common and best studied. It can be detected in nasopharyngeal swabs or washes, and it is often found as a co-infection with other respiratory viruses.

The medical definition of Bocavirus refers to this specific virus and its associated illnesses. The name "Bocavirus" comes from the initials of two diseases it causes in cattle: bovine parvovirus (BPV) and bovine rhinitis (BRSV) complex. In addition to humans, Bocaviruses have been identified in various animals, including dogs, cats, pigs, and non-human primates.

Densovirinae is a subfamily of single-stranded DNA viruses that primarily infect arthropods, including insects and crustaceans. These viruses are non-enveloped and have an icosahedral symmetry with a diameter of approximately 20-25 nanometers. The genome of Densovirinae is circular and encodes for several proteins involved in replication, capsid formation, and host cell manipulation.

Densoviruses, the viruses belonging to this subfamily, can cause diseases in their arthropod hosts, leading to developmental abnormalities, decreased fertility, and even death. However, they are not known to infect humans or other mammals and are not associated with any human diseases.

It's worth noting that Densovirinae is a subfamily of the family Parvoviridae, which also includes the subfamily Parvovirinae, whose members can infect vertebrates, including humans.

There is no medical definition for "dog diseases" as it is too broad a term. However, dogs can suffer from various health conditions and illnesses that are specific to their species or similar to those found in humans. Some common categories of dog diseases include:

1. Infectious Diseases: These are caused by viruses, bacteria, fungi, or parasites. Examples include distemper, parvovirus, kennel cough, Lyme disease, and heartworms.
2. Hereditary/Genetic Disorders: Some dogs may inherit certain genetic disorders from their parents. Examples include hip dysplasia, elbow dysplasia, progressive retinal atrophy (PRA), and degenerative myelopathy.
3. Age-Related Diseases: As dogs age, they become more susceptible to various health issues. Common age-related diseases in dogs include arthritis, dental disease, cancer, and cognitive dysfunction syndrome (CDS).
4. Nutritional Disorders: Malnutrition or improper feeding can lead to various health problems in dogs. Examples include obesity, malnutrition, and vitamin deficiencies.
5. Environmental Diseases: These are caused by exposure to environmental factors such as toxins, allergens, or extreme temperatures. Examples include heatstroke, frostbite, and toxicities from ingesting harmful substances.
6. Neurological Disorders: Dogs can suffer from various neurological conditions that affect their nervous system. Examples include epilepsy, intervertebral disc disease (IVDD), and vestibular disease.
7. Behavioral Disorders: Some dogs may develop behavioral issues due to various factors such as anxiety, fear, or aggression. Examples include separation anxiety, noise phobias, and resource guarding.

It's important to note that regular veterinary care, proper nutrition, exercise, and preventative measures can help reduce the risk of many dog diseases.

Immunoglobulin M (IgM) is a type of antibody that is primarily found in the blood and lymph fluid. It is the first antibody to be produced in response to an initial exposure to an antigen, making it an important part of the body's primary immune response. IgM antibodies are large molecules that are composed of five basic units, giving them a pentameric structure. They are primarily found on the surface of B cells as membrane-bound immunoglobulins (mlgM), where they function as receptors for antigens. Once an mlgM receptor binds to an antigen, it triggers the activation and differentiation of the B cell into a plasma cell that produces and secretes large amounts of soluble IgM antibodies.

IgM antibodies are particularly effective at agglutination (clumping) and complement activation, which makes them important in the early stages of an immune response to help clear pathogens from the bloodstream. However, they are not as stable or long-lived as other types of antibodies, such as IgG, and their levels tend to decline after the initial immune response has occurred.

In summary, Immunoglobulin M (IgM) is a type of antibody that plays a crucial role in the primary immune response to antigens by agglutination and complement activation. It is primarily found in the blood and lymph fluid, and it is produced by B cells after they are activated by an antigen.

Virus replication is the process by which a virus produces copies or reproduces itself inside a host cell. This involves several steps:

1. Attachment: The virus attaches to a specific receptor on the surface of the host cell.
2. Penetration: The viral genetic material enters the host cell, either by invagination of the cell membrane or endocytosis.
3. Uncoating: The viral genetic material is released from its protective coat (capsid) inside the host cell.
4. Replication: The viral genetic material uses the host cell's machinery to produce new viral components, such as proteins and nucleic acids.
5. Assembly: The newly synthesized viral components are assembled into new virus particles.
6. Release: The newly formed viruses are released from the host cell, often through lysis (breaking) of the cell membrane or by budding off the cell membrane.

The specific mechanisms and details of virus replication can vary depending on the type of virus. Some viruses, such as DNA viruses, use the host cell's DNA polymerase to replicate their genetic material, while others, such as RNA viruses, use their own RNA-dependent RNA polymerase or reverse transcriptase enzymes. Understanding the process of virus replication is important for developing antiviral therapies and vaccines.

I believe there might be a misunderstanding in your question. "Dogs" is not a medical term or condition. It is the common name for a domesticated carnivore of the family Canidae, specifically the genus Canis, which includes wolves, foxes, and other extant and extinct species of mammals. Dogs are often kept as pets and companions, and they have been bred in a wide variety of forms and sizes for different purposes, such as hunting, herding, guarding, assisting police and military forces, and providing companionship and emotional support.

If you meant to ask about a specific medical condition or term related to dogs, please provide more context so I can give you an accurate answer.

Polymerase Chain Reaction (PCR) is a laboratory technique used to amplify specific regions of DNA. It enables the production of thousands to millions of copies of a particular DNA sequence in a rapid and efficient manner, making it an essential tool in various fields such as molecular biology, medical diagnostics, forensic science, and research.

The PCR process involves repeated cycles of heating and cooling to separate the DNA strands, allow primers (short sequences of single-stranded DNA) to attach to the target regions, and extend these primers using an enzyme called Taq polymerase, resulting in the exponential amplification of the desired DNA segment.

In a medical context, PCR is often used for detecting and quantifying specific pathogens (viruses, bacteria, fungi, or parasites) in clinical samples, identifying genetic mutations or polymorphisms associated with diseases, monitoring disease progression, and evaluating treatment effectiveness.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

Purpura is a medical term that refers to the appearance of purple-colored spots on the skin or mucous membranes, caused by bleeding underneath the skin due to various factors such as blood clotting disorders, vasculitis (inflammation of the blood vessels), severe thrombocytopenia (low platelet count), or use of certain medications. These spots can vary in size and shape, ranging from small pinpoint hemorrhages (petechiae) to larger, irregularly shaped patches (ecchymoses). The bleeding is usually not caused by trauma or injury to the area. It's important to consult a healthcare professional if you notice any unexplained purpuric spots on your skin or mucous membranes, as they can indicate an underlying medical condition that requires further evaluation and treatment.

Human bocavirus (HBoV) is a species of parvovirus that primarily infects the human respiratory tract. It was first identified in 2005 and has been found to be associated with respiratory tract infections, particularly in young children. The virus is small, non-enveloped, and contains a single stranded DNA genome. It is named after bovine parvovirus and canine minute virus, which belong to the same genus (Bocaparvovirus) as HBoV. There are four known subtypes of HBoV (HBoV1-4), with HBoV1 being the most commonly detected in humans. Infection with HBoV can cause a range of symptoms, from mild respiratory illness to more severe lower respiratory tract infections such as pneumonia and bronchiolitis. However, it is also frequently detected in asymptomatic individuals, making its role in respiratory disease somewhat unclear.

An aborted fetus refers to a developing human organism that is expelled or removed from the uterus before it is viable, typically as a result of an induced abortion. An abortion is a medical procedure that intentionally ends a pregnancy and can be performed through various methods, depending on the stage of the pregnancy.

It's important to note that the term "abortion" is often used in different contexts and may carry different connotations depending on one's perspective. In medical terminology, an abortion refers specifically to the intentional ending of a pregnancy before viability. However, in other contexts, the term may be used more broadly to refer to any spontaneous or induced loss of a pregnancy, including miscarriages and stillbirths.

The definition of "viable" can vary, but it generally refers to the point at which a fetus can survive outside the uterus with medical assistance, typically around 24 weeks of gestation. Fetal viability is a complex issue that depends on many factors, including the availability and accessibility of medical technology and resources.

In summary, an aborted fetus is a developing human organism that is intentionally expelled or removed from the uterus before it is viable, typically as a result of a medical procedure called an abortion.

I'm sorry for any confusion, but "geese" is not a medical term. It refers to various waterbirds constituting the family Anatidae and the genus Branta, characterized by a long neck, wide wings, and a honking call. They are not related to human health or medicine. If you have any medical concerns or questions, I'd be happy to help you with those!

A densovirus is a type of single-stranded DNA virus that belongs to the family Parvoviridae and the subfamily Densovirinae. These viruses are known to infect insects, including crustaceans and arthropods, and are often associated with diseases in these hosts. They have a small, icosahedral capsid and a linear, ssDNA genome that is around 5-6 kilobases in length. Densoviruses are non-enveloped viruses, meaning they do not have a lipid membrane surrounding their capsid.

It's important to note that densoviruses are not known to infect humans or other mammals, and therefore are not considered a threat to human health.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

A viral genome is the genetic material (DNA or RNA) that is present in a virus. It contains all the genetic information that a virus needs to replicate itself and infect its host. The size and complexity of viral genomes can vary greatly, ranging from a few thousand bases to hundreds of thousands of bases. Some viruses have linear genomes, while others have circular genomes. The genome of a virus also contains the information necessary for the virus to hijack the host cell's machinery and use it to produce new copies of the virus. Understanding the genetic makeup of viruses is important for developing vaccines and antiviral treatments.

"Cat" is a common name that refers to various species of small carnivorous mammals that belong to the family Felidae. The domestic cat, also known as Felis catus or Felis silvestris catus, is a popular pet and companion animal. It is a subspecies of the wildcat, which is found in Europe, Africa, and Asia.

Domestic cats are often kept as pets because of their companionship, playful behavior, and ability to hunt vermin. They are also valued for their ability to provide emotional support and therapy to people. Cats are obligate carnivores, which means that they require a diet that consists mainly of meat to meet their nutritional needs.

Cats are known for their agility, sharp senses, and predatory instincts. They have retractable claws, which they use for hunting and self-defense. Cats also have a keen sense of smell, hearing, and vision, which allow them to detect prey and navigate their environment.

In medical terms, cats can be hosts to various parasites and diseases that can affect humans and other animals. Some common feline diseases include rabies, feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and toxoplasmosis. It is important for cat owners to keep their pets healthy and up-to-date on vaccinations and preventative treatments to protect both the cats and their human companions.

A cell line is a culture of cells that are grown in a laboratory for use in research. These cells are usually taken from a single cell or group of cells, and they are able to divide and grow continuously in the lab. Cell lines can come from many different sources, including animals, plants, and humans. They are often used in scientific research to study cellular processes, disease mechanisms, and to test new drugs or treatments. Some common types of human cell lines include HeLa cells (which come from a cancer patient named Henrietta Lacks), HEK293 cells (which come from embryonic kidney cells), and HUVEC cells (which come from umbilical vein endothelial cells). It is important to note that cell lines are not the same as primary cells, which are cells that are taken directly from a living organism and have not been grown in the lab.

Myelophthisic anemia is a type of anemia that occurs when the bone marrow becomes replaced or damaged by fibrosis, tumor infiltration, or other disorders, leading to decreased production of blood cells. This results in a decrease in all three types of blood cells - red blood cells, white blood cells, and platelets.

The symptoms of myelophthisic anemia may include fatigue, weakness, shortness of breath, frequent infections, and easy bruising or bleeding. The diagnosis is typically made through a combination of medical history, physical examination, complete blood count (CBC), and bone marrow aspiration and biopsy. Treatment for myelophthisic anemia depends on the underlying cause and may include chemotherapy, radiation therapy, surgery, or supportive care with transfusions of red blood cells or platelets.

Rodent-borne diseases are infectious diseases transmitted to humans (and other animals) by rodents, their parasites or by contact with rodent urine, feces, or saliva. These diseases can be caused by viruses, bacteria, fungi, or parasites. Some examples of rodent-borne diseases include Hantavirus Pulmonary Syndrome, Leptospirosis, Salmonellosis, Rat-bite fever, and Plague. It's important to note that rodents can also cause allergic reactions in some people through their dander, urine, or saliva. Proper sanitation, rodent control measures, and protective equipment when handling rodents can help prevent the spread of these diseases.

The P blood group system is one of the rarest blood group systems in humans, with only a few antigens discovered so far. The main antigens in this system are P1 and P, which can be either present or absent on red blood cells (RBCs). The presence or absence of these antigens determines an individual's P blood group type.

The P1 antigen is a carbohydrate structure found on the surface of RBCs in individuals with the P1 phenotype, while those with the p phenotype lack this antigen. The P antigen is a protein found on the surface of RBCs in both P1 and p individuals.

Individuals with the P1 phenotype can develop antibodies against the P antigen if they are exposed to RBCs that lack the P1 antigen, such as those from a person with the p phenotype. Similarly, individuals with the p phenotype can develop antibodies against the P1 antigen if they are exposed to RBCs that have the P1 antigen.

Transfusion reactions can occur if an individual receives blood from a donor with a different P blood group type, leading to the destruction of RBCs and potentially life-threatening complications. Therefore, it is essential to determine an individual's P blood group type before transfusing blood or performing other medical procedures that involve RBCs.

Overall, the P blood group system is a complex and relatively rare system that requires careful consideration in medical settings to ensure safe and effective treatment.

A dependovirus, also known as a dependent adenovirus or satellite adenovirus, is a type of virus that requires the presence of another virus, specifically an adenovirus, to replicate. Dependoviruses are small, non-enveloped viruses with a double-stranded DNA genome. They cannot complete their replication cycle without the help of an adenovirus, which provides necessary functions for the dependovirus to replicate.

Dependoviruses are clinically significant because they can cause disease in humans, particularly in individuals with weakened immune systems. In some cases, dependoviruses may also affect the severity and outcome of adenovirus infections. However, it is important to note that not all adenovirus infections are associated with dependovirus co-infections.

An exanthem is a skin eruption or rash that often occurs as a symptom of various diseases, such as infectious illnesses. It can appear in different forms, including maculopapular (consisting of both macules and papules), vesicular (small fluid-filled blisters), petechial (small purple or red spots caused by bleeding under the skin), or erythematous (reddened). The rash can be localized to certain areas of the body or generalized, covering large parts or the entire body. Exanthems are usually accompanied by other symptoms related to the underlying disease, such as fever, cough, or muscle aches.

An antigen is any substance that can stimulate an immune response, particularly the production of antibodies. Viral antigens are antigens that are found on or produced by viruses. They can be proteins, glycoproteins, or carbohydrates present on the surface or inside the viral particle.

Viral antigens play a crucial role in the immune system's recognition and response to viral infections. When a virus infects a host cell, it may display its antigens on the surface of the infected cell. This allows the immune system to recognize and target the infected cells for destruction, thereby limiting the spread of the virus.

Viral antigens are also important targets for vaccines. Vaccines typically work by introducing a harmless form of a viral antigen to the body, which then stimulates the production of antibodies and memory T-cells that can recognize and respond quickly and effectively to future infections with the actual virus.

It's worth noting that different types of viruses have different antigens, and these antigens can vary between strains of the same virus. This is why there are often different vaccines available for different viral diseases, and why flu vaccines need to be updated every year to account for changes in the circulating influenza virus strains.

Immunoglobulin G (IgG) is a type of antibody, which is a protective protein produced by the immune system in response to foreign substances like bacteria or viruses. IgG is the most abundant type of antibody in human blood, making up about 75-80% of all antibodies. It is found in all body fluids and plays a crucial role in fighting infections caused by bacteria, viruses, and toxins.

IgG has several important functions:

1. Neutralization: IgG can bind to the surface of bacteria or viruses, preventing them from attaching to and infecting human cells.
2. Opsonization: IgG coats the surface of pathogens, making them more recognizable and easier for immune cells like neutrophils and macrophages to phagocytose (engulf and destroy) them.
3. Complement activation: IgG can activate the complement system, a group of proteins that work together to help eliminate pathogens from the body. Activation of the complement system leads to the formation of the membrane attack complex, which creates holes in the cell membranes of bacteria, leading to their lysis (destruction).
4. Antibody-dependent cellular cytotoxicity (ADCC): IgG can bind to immune cells like natural killer (NK) cells and trigger them to release substances that cause target cells (such as virus-infected or cancerous cells) to undergo apoptosis (programmed cell death).
5. Immune complex formation: IgG can form immune complexes with antigens, which can then be removed from the body through various mechanisms, such as phagocytosis by immune cells or excretion in urine.

IgG is a critical component of adaptive immunity and provides long-lasting protection against reinfection with many pathogens. It has four subclasses (IgG1, IgG2, IgG3, and IgG4) that differ in their structure, function, and distribution in the body.

Infectious pregnancy complications refer to infections that occur during pregnancy and can affect the mother, fetus, or both. These infections can lead to serious consequences such as preterm labor, low birth weight, birth defects, stillbirth, or even death. Some common infectious agents that can cause pregnancy complications include:

1. Bacteria: Examples include group B streptococcus, Escherichia coli, and Listeria monocytogenes, which can cause sepsis, meningitis, or pneumonia in the mother and lead to preterm labor or stillbirth.
2. Viruses: Examples include cytomegalovirus, rubella, varicella-zoster, and HIV, which can cause congenital anomalies, developmental delays, or transmission of the virus to the fetus.
3. Parasites: Examples include Toxoplasma gondii, which can cause severe neurological damage in the fetus if transmitted during pregnancy.
4. Fungi: Examples include Candida albicans, which can cause fungal infections in the mother and lead to preterm labor or stillbirth.

Preventive measures such as vaccination, good hygiene practices, and avoiding high-risk behaviors can help reduce the risk of infectious pregnancy complications. Prompt diagnosis and treatment of infections during pregnancy are also crucial to prevent adverse outcomes.

I'm sorry for any confusion, but "Foxes" is not a term that has a widely accepted or specific medical definition. The common fox (Vulpes vulpes) is a species of small omnivorous mammals, and while there can be medical issues related to foxes or other animals in certain contexts, such as zoonotic diseases, "Foxes" itself does not have a medical connotation. If you have any specific medical query, I'd be happy to try and help with that.

Seroepidemiologic studies are a type of epidemiological study that measures the presence and levels of antibodies in a population's blood serum to investigate the prevalence, distribution, and transmission of infectious diseases. These studies help to identify patterns of infection and immunity within a population, which can inform public health policies and interventions.

Seroepidemiologic studies typically involve collecting blood samples from a representative sample of individuals in a population and testing them for the presence of antibodies against specific pathogens. The results are then analyzed to estimate the prevalence of infection and immunity within the population, as well as any factors associated with increased or decreased risk of infection.

These studies can provide valuable insights into the spread of infectious diseases, including emerging and re-emerging infections, and help to monitor the effectiveness of vaccination programs. Additionally, seroepidemiologic studies can also be used to investigate the transmission dynamics of infectious agents, such as identifying sources of infection or tracking the spread of antibiotic resistance.

DNA replication is the biological process by which DNA makes an identical copy of itself during cell division. It is a fundamental mechanism that allows genetic information to be passed down from one generation of cells to the next. During DNA replication, each strand of the double helix serves as a template for the synthesis of a new complementary strand. This results in the creation of two identical DNA molecules. The enzymes responsible for DNA replication include helicase, which unwinds the double helix, and polymerase, which adds nucleotides to the growing strands.

Carnivora is an order of mammals that consists of animals whose primary diet consists of flesh. The term "Carnivora" comes from the Latin words "caro", meaning flesh, and "vorare", meaning to devour. This order includes a wide variety of species, ranging from large predators such as lions, tigers, and bears, to smaller animals such as weasels, otters, and raccoons.

While members of the Carnivora order are often referred to as "carnivores," it is important to note that not all members exclusively eat meat. Some species, such as raccoons and bears, have an omnivorous diet that includes both plants and animals. Additionally, some species within this order have evolved specialized adaptations for their specific diets, such as the elongated canines and carnassial teeth of felids (cats) and canids (dogs), which are adapted for tearing and shearing meat.

Overall, the medical definition of Carnivora refers to an order of mammals that have a diet primarily consisting of flesh, although not all members exclusively eat meat.

Fetal death, also known as stillbirth or intrauterine fetal demise, is defined as the death of a fetus at 20 weeks of gestation or later. The criteria for defining fetal death may vary slightly by country and jurisdiction, but in general, it refers to the loss of a pregnancy after the point at which the fetus is considered viable outside the womb.

Fetal death can occur for a variety of reasons, including chromosomal abnormalities, placental problems, maternal health conditions, infections, and umbilical cord accidents. In some cases, the cause of fetal death may remain unknown.

The diagnosis of fetal death is typically made through ultrasound or other imaging tests, which can confirm the absence of a heartbeat or movement in the fetus. Once fetal death has been diagnosed, medical professionals will work with the parents to determine the best course of action for managing the pregnancy and delivering the fetus. This may involve waiting for labor to begin naturally, inducing labor, or performing a cesarean delivery.

Experiencing a fetal death can be a very difficult and emotional experience for parents, and it is important for them to receive supportive care from their healthcare providers, family members, and friends. Grief counseling and support groups may also be helpful in coping with the loss.

Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by selective absence or severe reduction in the production of mature red blood cells (erythropoiesis) in the bone marrow, while the production of other blood cell lines such as white blood cells and platelets remains normal or near normal. This condition leads to anemia, which can be severe and require transfusions.

In PRCA, there is a specific absence or reduction of erythroblasts (immature red blood cells) in the bone marrow. The cause of this disorder can be congenital or acquired. Acquired forms are more common and can be idiopathic or associated with various conditions such as viral infections, immunological disorders, drugs, malignancies, or autoimmune diseases.

In pure red cell aplasia, the immune system often produces antibodies against erythroid progenitor cells, leading to their destruction and impaired red blood cell production. This results in anemia, which can be severe and require regular transfusions to maintain adequate hemoglobin levels.

The diagnosis of PRCA is confirmed through bone marrow aspiration and biopsy, which reveal a marked decrease or absence of erythroid precursors. Additional tests, such as immunological studies and viral serologies, may be performed to identify potential causes or associated conditions. Treatment options depend on the underlying cause and can include corticosteroids, immunosuppressive therapy, intravenous immunoglobulins, and occasionally, targeted therapies or stem cell transplantation.

Phylogeny is the evolutionary history and relationship among biological entities, such as species or genes, based on their shared characteristics. In other words, it refers to the branching pattern of evolution that shows how various organisms have descended from a common ancestor over time. Phylogenetic analysis involves constructing a tree-like diagram called a phylogenetic tree, which depicts the inferred evolutionary relationships among organisms or genes based on molecular sequence data or other types of characters. This information is crucial for understanding the diversity and distribution of life on Earth, as well as for studying the emergence and spread of diseases.

Intrauterine blood transfusion (IUT) is a medical procedure in which blood is transfused into the fetal circulation through the umbilical vein while the fetus is still in the uterus. This procedure is typically performed to treat severe anemia in the fetus, most commonly caused by hemolytic disease of the newborn due to Rh incompatibility or ABO incompatibility between the mother and fetus.

During the procedure, ultrasound guidance is used to insert a thin needle through the mother's abdomen and uterus and into the umbilical vein of the fetus. The blood is then transfused slowly, allowing the fetal body to adjust to the increased volume. The procedure may need to be repeated every 2-4 weeks until the baby is mature enough for delivery.

IUT is a highly specialized procedure that requires significant expertise and experience in maternal-fetal medicine and interventional radiology. It carries risks such as preterm labor, infection, fetal bradycardia (abnormally slow heart rate), and fetal loss, but it can be life-saving for the fetus when performed appropriately.

Canid herpesvirus 1 (CHV-1), also known as canine herpesvirus or cytomegalovirus, is a DNA virus belonging to the family Herpesviridae, subfamily Alphaherpesvirinae, and genus Varicellovirus. It primarily affects members of the Canidae family, including domestic dogs (Canis lupus familiaris) and other canid species.

CHV-1 is characterized by its ability to cause a range of clinical signs, from asymptomatic infection to acute fatal disease in young puppies. The virus mainly targets the respiratory and reproductive systems, leading to conditions such as fading puppy syndrome, stillbirths, neonatal deaths, and respiratory issues in adult dogs.

The virus is highly contagious and can be transmitted through direct contact with infected animals, their bodily fluids (e.g., saliva, urine), or contaminated objects. CHV-1 has a predilection for infecting epithelial cells and macrophages in the host, leading to the formation of characteristic intranuclear inclusion bodies.

Despite its potential to cause severe disease, many adult dogs can become latently infected with CHV-1, meaning that the virus remains dormant within their nervous system without causing any apparent clinical signs. However, stress or immunosuppression may reactivate the virus, leading to recurrent shedding and potential transmission to other susceptible animals.

Prevention strategies for CHV-1 include good biosecurity measures, such as isolating newly introduced dogs from the existing population, maintaining cleanliness in breeding facilities, and avoiding overcrowding. Vaccination is available in some countries; however, its efficacy varies, and it may not prevent infection or shedding entirely.

Viral proteins are the proteins that are encoded by the viral genome and are essential for the viral life cycle. These proteins can be structural or non-structural and play various roles in the virus's replication, infection, and assembly process. Structural proteins make up the physical structure of the virus, including the capsid (the protein shell that surrounds the viral genome) and any envelope proteins (that may be present on enveloped viruses). Non-structural proteins are involved in the replication of the viral genome and modulation of the host cell environment to favor viral replication. Overall, a thorough understanding of viral proteins is crucial for developing antiviral therapies and vaccines.

Viral diseases are illnesses caused by the infection and replication of viruses in host organisms. These infectious agents are obligate parasites, meaning they rely on the cells of other living organisms to survive and reproduce. Viruses can infect various types of hosts, including animals, plants, and microorganisms, causing a wide range of diseases with varying symptoms and severity.

Once a virus enters a host cell, it takes over the cell's machinery to produce new viral particles, often leading to cell damage or death. The immune system recognizes the viral components as foreign and mounts an immune response to eliminate the infection. This response can result in inflammation, fever, and other symptoms associated with viral diseases.

Examples of well-known viral diseases include:

1. Influenza (flu) - caused by influenza A, B, or C viruses
2. Common cold - usually caused by rhinoviruses or coronaviruses
3. HIV/AIDS - caused by human immunodeficiency virus (HIV)
4. Measles - caused by measles morbillivirus
5. Hepatitis B and C - caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), respectively
6. Herpes simplex - caused by herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2)
7. Chickenpox and shingles - both caused by varicella-zoster virus (VZV)
8. Rabies - caused by rabies lyssavirus
9. Ebola - caused by ebolaviruses
10. COVID-19 - caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Prevention and treatment strategies for viral diseases may include vaccination, antiviral medications, and supportive care to manage symptoms while the immune system fights off the infection.

Mink enteritis virus (MEV) is a single-stranded, enveloped RNA virus that belongs to the family *Parvoviridae* and genus *Chapparvovirus*. It is the causative agent of mink enteritis, a highly contagious gastrointestinal disease in minks. The virus primarily affects the intestinal epithelium, causing severe enteritis, which can lead to diarrhea, vomiting, dehydration, and death, particularly in young animals. MEV is closely related to other parvoviruses that infect carnivores, such as feline panleukopenia virus (FPV) and canine parvovirus (CPV).

Aplastic anemia is a medical condition characterized by pancytopenia (a decrease in all three types of blood cells: red blood cells, white blood cells, and platelets) due to the failure of bone marrow to produce new cells. It is called "aplastic" because the bone marrow becomes hypocellular or "aplastic," meaning it contains few or no blood-forming stem cells.

The condition can be acquired or inherited, with acquired aplastic anemia being more common. Acquired aplastic anemia can result from exposure to toxic chemicals, radiation, drugs, viral infections, or autoimmune disorders. Inherited forms of the disease include Fanconi anemia and dyskeratosis congenita.

Symptoms of aplastic anemia may include fatigue, weakness, shortness of breath, pale skin, easy bruising or bleeding, frequent infections, and fever. Treatment options for aplastic anemia depend on the severity of the condition and its underlying cause. They may include blood transfusions, immunosuppressive therapy, and stem cell transplantation.

Viral genes refer to the genetic material present in viruses that contains the information necessary for their replication and the production of viral proteins. In DNA viruses, the genetic material is composed of double-stranded or single-stranded DNA, while in RNA viruses, it is composed of single-stranded or double-stranded RNA.

Viral genes can be classified into three categories: early, late, and structural. Early genes encode proteins involved in the replication of the viral genome, modulation of host cell processes, and regulation of viral gene expression. Late genes encode structural proteins that make up the viral capsid or envelope. Some viruses also have structural genes that are expressed throughout their replication cycle.

Understanding the genetic makeup of viruses is crucial for developing antiviral therapies and vaccines. By targeting specific viral genes, researchers can develop drugs that inhibit viral replication and reduce the severity of viral infections. Additionally, knowledge of viral gene sequences can inform the development of vaccines that stimulate an immune response to specific viral proteins.

Erythroid precursor cells, also known as erythroblasts or normoblasts, are early stage cells in the process of producing mature red blood cells (erythrocytes) in the bone marrow. These cells are derived from hematopoietic stem cells and undergo a series of maturation stages, including proerythroblast, basophilic erythroblast, polychromatophilic erythroblast, and orthochromatic erythroblast, before becoming reticulocytes and then mature red blood cells. During this maturation process, the cells lose their nuclei and become enucleated, taking on the biconcave shape and flexible membrane that allows them to move through small blood vessels and deliver oxygen to tissues throughout the body.

I'm sorry for any confusion, but the term "hepatopancreas" is not a recognized term in human anatomy or pathology. It is commonly used to describe a combined exocrine organ in some invertebrates, like crustaceans, where it serves both digestive and metabolic functions. If you have any questions about human medical conditions, I'd be happy to help with those!

Circoviridae is a family of small, non-enveloped viruses that infect a wide range of hosts, including animals and birds. The infection caused by circoviruses in animals and birds can result in a variety of symptoms depending on the species infected and the particular circovirus involved.

In pigs, circovirus type 2 (PCV2) is the most well-known member of this family and is associated with a number of clinical conditions, collectively known as porcine circovirus diseases (PCVD). These conditions include postweaning multisystemic wasting syndrome (PMWS), porcine dermatitis and nephropathy syndrome (PDNS), and reproductive failure.

In birds, circoviruses can cause various symptoms such as runting and stunting, feather abnormalities, and immunosuppression, leading to secondary infections. The most well-known avian circovirus is the beak and feather disease virus (BFDV), which infects psittacine birds, including parrots, causing beak deformities, feather loss, and immune suppression.

However, it's important to note that circoviruses are also found in humans, but currently, there is no evidence that human circovirus infections cause disease.

In general, circoviridae infections can be diagnosed through various laboratory tests such as PCR, sequencing, and serology. Treatment typically involves supportive care and management of secondary infections, as there are no specific antiviral therapies available for circovirus infections. Prevention strategies include good biosecurity practices, vaccination, and avoidance of contact with infected animals or their feces.

Hemagglutination is a process where red blood cells (RBCs) agglutinate or clump together. Viral hemagglutination refers to the ability of certain viruses to bind to and agglutinate RBCs. This is often due to viral surface proteins known as hemagglutinins, which can recognize and attach to specific receptors on the surface of RBCs.

In virology, viral hemagglutination assays are commonly used for virus identification and quantification. For example, the influenza virus is known to hemagglutinate chicken RBCs, and this property can be used to identify and titrate the virus in a sample. The hemagglutination titer is the highest dilution of a virus that still causes visible agglutination of RBCs. This information can be useful in understanding the viral load in a patient or during vaccine production.

Anemia is a medical condition characterized by a lower than normal number of red blood cells or lower than normal levels of hemoglobin in the blood. Hemoglobin is an important protein in red blood cells that carries oxygen from the lungs to the rest of the body. Anemia can cause fatigue, weakness, shortness of breath, and a pale complexion because the body's tissues are not getting enough oxygen.

Anemia can be caused by various factors, including nutritional deficiencies (such as iron, vitamin B12, or folate deficiency), blood loss, chronic diseases (such as kidney disease or rheumatoid arthritis), inherited genetic disorders (such as sickle cell anemia or thalassemia), and certain medications.

There are different types of anemia, classified based on the underlying cause, size and shape of red blood cells, and the level of hemoglobin in the blood. Treatment for anemia depends on the underlying cause and may include dietary changes, supplements, medication, or blood transfusions.

Swine diseases refer to a wide range of infectious and non-infectious conditions that affect pigs. These diseases can be caused by viruses, bacteria, fungi, parasites, or environmental factors. Some common swine diseases include:

1. Porcine Reproductive and Respiratory Syndrome (PRRS): a viral disease that causes reproductive failure in sows and respiratory problems in piglets and grower pigs.
2. Classical Swine Fever (CSF): also known as hog cholera, is a highly contagious viral disease that affects pigs of all ages.
3. Porcine Circovirus Disease (PCVD): a group of diseases caused by porcine circoviruses, including Porcine CircoVirus Associated Disease (PCVAD) and Postweaning Multisystemic Wasting Syndrome (PMWS).
4. Swine Influenza: a respiratory disease caused by type A influenza viruses that can infect pigs and humans.
5. Mycoplasma Hyopneumoniae: a bacterial disease that causes pneumonia in pigs.
6. Actinobacillus Pleuropneumoniae: a bacterial disease that causes severe pneumonia in pigs.
7. Salmonella: a group of bacteria that can cause food poisoning in humans and a variety of diseases in pigs, including septicemia, meningitis, and abortion.
8. Brachyspira Hyodysenteriae: a bacterial disease that causes dysentery in pigs.
9. Erysipelothrix Rhusiopathiae: a bacterial disease that causes erysipelas in pigs.
10. External and internal parasites, such as lice, mites, worms, and flukes, can also cause diseases in swine.

Prevention and control of swine diseases rely on good biosecurity practices, vaccination programs, proper nutrition, and management practices. Regular veterinary check-ups and monitoring are essential to detect and treat diseases early.

Circoviruses are a type of small, non-enveloped viruses that belong to the family Circoviridae. They have a single-stranded, circular DNA genome and can infect a wide range of hosts, including birds, pigs, and some mammals. Circoviruses are associated with various diseases in animals, such as porcine circovirus-associated disease (PCVAD) in pigs and beak and feather disease in birds. However, there is currently no evidence to suggest that circoviruses infect or cause disease in humans.

I apologize for any confusion, but "Penaeidae" is not a medical term. It is actually the scientific name of a family of crustaceans, specifically marine decapods, commonly known as prawns or shrimps. If you have any questions about medical terminology or concepts, I would be happy to help with those instead.

An amino acid sequence is the specific order of amino acids in a protein or peptide molecule, formed by the linking of the amino group (-NH2) of one amino acid to the carboxyl group (-COOH) of another amino acid through a peptide bond. The sequence is determined by the genetic code and is unique to each type of protein or peptide. It plays a crucial role in determining the three-dimensional structure and function of proteins.

I'm sorry for any confusion, but "raccoons" are not a medical term. They are a species of nocturnal mammals native to North America, known for their distinctive black facial mask and ringed tails. If you have any questions about animals or a medical condition, feel free to ask!

Viral structural proteins are the protein components that make up the viral particle or capsid, providing structure and stability to the virus. These proteins are encoded by the viral genome and are involved in the assembly of new virus particles during the replication cycle. They can be classified into different types based on their location and function, such as capsid proteins, matrix proteins, and envelope proteins. Capsid proteins form the protein shell that encapsulates the viral genome, while matrix proteins are located between the capsid and the envelope, and envelope proteins are embedded in the lipid bilayer membrane that surrounds some viruses.

A virion is the complete, infectious form of a virus outside its host cell. It consists of the viral genome (DNA or RNA) enclosed within a protein coat called the capsid, which is often surrounded by a lipid membrane called the envelope. The envelope may contain viral proteins and glycoproteins that aid in attachment to and entry into host cells during infection. The term "virion" emphasizes the infectious nature of the virus particle, as opposed to non-infectious components like individual capsid proteins or naked viral genome.

Infectious arthritis, also known as septic arthritis, is a type of joint inflammation that is caused by a bacterial or fungal infection. The infection can enter the joint through the bloodstream or directly into the synovial fluid of the joint, often as a result of a traumatic injury, surgery, or an underlying condition such as diabetes or a weakened immune system.

The most common symptoms of infectious arthritis include sudden onset of severe pain and swelling in the affected joint, fever, chills, and difficulty moving the joint. If left untreated, infectious arthritis can lead to serious complications such as joint damage or destruction, sepsis, and even death. Treatment typically involves antibiotics or antifungal medications to eliminate the infection, along with rest, immobilization, and sometimes surgery to drain the infected synovial fluid.

It is important to seek medical attention promptly if you experience symptoms of infectious arthritis, as early diagnosis and treatment can help prevent long-term complications and improve outcomes.

Myocarditis is an inflammation of the myocardium, which is the middle layer of the heart wall. The myocardium is composed of cardiac muscle cells and is responsible for the heart's pumping function. Myocarditis can be caused by various infectious and non-infectious agents, including viruses, bacteria, fungi, parasites, autoimmune diseases, toxins, and drugs.

In myocarditis, the inflammation can damage the cardiac muscle cells, leading to decreased heart function, arrhythmias (irregular heart rhythms), and in severe cases, heart failure or even sudden death. Symptoms of myocarditis may include chest pain, shortness of breath, fatigue, palpitations, and swelling in the legs, ankles, or abdomen.

The diagnosis of myocarditis is often based on a combination of clinical presentation, laboratory tests, electrocardiogram (ECG), echocardiography, cardiac magnetic resonance imaging (MRI), and endomyocardial biopsy. Treatment depends on the underlying cause and severity of the disease and may include medications to support heart function, reduce inflammation, control arrhythmias, and prevent further damage to the heart muscle. In some cases, hospitalization and intensive care may be necessary.

A viral vaccine is a biological preparation that introduces your body to a specific virus in a way that helps your immune system build up protection against the virus without causing the illness. Viral vaccines can be made from weakened or inactivated forms of the virus, or parts of the virus such as proteins or sugars. Once introduced to the body, the immune system recognizes the virus as foreign and produces an immune response, including the production of antibodies. These antibodies remain in the body and provide immunity against future infection with that specific virus.

Viral vaccines are important tools for preventing infectious diseases caused by viruses, such as influenza, measles, mumps, rubella, polio, hepatitis A and B, rabies, rotavirus, chickenpox, shingles, and some types of cancer. Vaccination programs have led to the control or elimination of many infectious diseases that were once common.

It's important to note that viral vaccines are not effective against bacterial infections, and separate vaccines must be developed for each type of virus. Additionally, because viruses can mutate over time, it is necessary to update some viral vaccines periodically to ensure continued protection.

Globosides are a type of glycosphingolipids, which are molecules that consist of a lipid and a carbohydrate. They are found in animal tissues, especially in the nervous system. The term "globoside" refers to a specific structure of these molecules, where the carbohydrate portion consists of a complex chain of sugars, including galactose, N-acetylgalactosamine, and glucose. Globosides play important roles in cell recognition and interaction, and abnormalities in their metabolism have been associated with certain diseases, such as paroxysmal nocturnal hemoglobinuria (PNH).

Pregnancy is a physiological state or condition where a fertilized egg (zygote) successfully implants and grows in the uterus of a woman, leading to the development of an embryo and finally a fetus. This process typically spans approximately 40 weeks, divided into three trimesters, and culminates in childbirth. Throughout this period, numerous hormonal and physical changes occur to support the growing offspring, including uterine enlargement, breast development, and various maternal adaptations to ensure the fetus's optimal growth and well-being.

"Phoca" is not a term commonly used in medical terminology. It is actually a genus of seals, also known as "true seals." The Phocidae family includes several species such as the harbor seal, gray seal, and hooded seal. If you have mistaken "Phoca" for a medical term, I would be happy to help you find the definition of the correct term.

An Enzyme-Linked Immunosorbent Assay (ELISA) is a type of analytical biochemistry assay used to detect and quantify the presence of a substance, typically a protein or peptide, in a liquid sample. It takes its name from the enzyme-linked antibodies used in the assay.

In an ELISA, the sample is added to a well containing a surface that has been treated to capture the target substance. If the target substance is present in the sample, it will bind to the surface. Next, an enzyme-linked antibody specific to the target substance is added. This antibody will bind to the captured target substance if it is present. After washing away any unbound material, a substrate for the enzyme is added. If the enzyme is present due to its linkage to the antibody, it will catalyze a reaction that produces a detectable signal, such as a color change or fluorescence. The intensity of this signal is proportional to the amount of target substance present in the sample, allowing for quantification.

ELISAs are widely used in research and clinical settings to detect and measure various substances, including hormones, viruses, and bacteria. They offer high sensitivity, specificity, and reproducibility, making them a reliable choice for many applications.

Pancytopenia is a medical condition characterized by a reduction in the number of all three types of blood cells in the peripheral blood: red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). This condition can be caused by various underlying diseases, including bone marrow disorders, viral infections, exposure to toxic substances or radiation, vitamin deficiencies, and certain medications. Symptoms of pancytopenia may include fatigue, weakness, increased susceptibility to infections, and easy bruising or bleeding.

Oncolytic viruses are a type of viruses that preferentially infect and kill cancer cells, while leaving normal cells relatively unharmed. These viruses can replicate inside the cancer cells, causing them to rupture and ultimately leading to their death. The release of new virus particles from the dead cancer cells allows the infection to spread to nearby cancer cells, resulting in a potential therapeutic effect.

Oncolytic viruses can be genetically modified to enhance their ability to target specific types of cancer cells and to increase their safety and efficacy. They may also be used in combination with other cancer therapies, such as chemotherapy or radiation therapy, to improve treatment outcomes. Oncolytic virus therapy is a promising area of cancer research, with several clinical trials underway to evaluate its potential benefits for patients with various types of cancer.

Meningoencephalitis is a medical term that refers to an inflammation of both the brain (encephalitis) and the membranes covering the brain and spinal cord (meninges), known as the meninges. It is often caused by an infection, such as bacterial or viral infections, that spreads to the meninges and brain. In some cases, it can also be caused by other factors like autoimmune disorders or certain medications.

The symptoms of meningoencephalitis may include fever, headache, stiff neck, confusion, seizures, and changes in mental status. If left untreated, this condition can lead to serious complications, such as brain damage, hearing loss, learning disabilities, or even death. Treatment typically involves antibiotics for bacterial infections or antiviral medications for viral infections, along with supportive care to manage symptoms and prevent complications.

DNA Sequence Analysis is the systematic determination of the order of nucleotides in a DNA molecule. It is a critical component of modern molecular biology, genetics, and genetic engineering. The process involves determining the exact order of the four nucleotide bases - adenine (A), guanine (G), cytosine (C), and thymine (T) - in a DNA molecule or fragment. This information is used in various applications such as identifying gene mutations, studying evolutionary relationships, developing molecular markers for breeding, and diagnosing genetic diseases.

The process of DNA Sequence Analysis typically involves several steps, including DNA extraction, PCR amplification (if necessary), purification, sequencing reaction, and electrophoresis. The resulting data is then analyzed using specialized software to determine the exact sequence of nucleotides.

In recent years, high-throughput DNA sequencing technologies have revolutionized the field of genomics, enabling the rapid and cost-effective sequencing of entire genomes. This has led to an explosion of genomic data and new insights into the genetic basis of many diseases and traits.

To the Editor: In the past few years, several novel parvoviruses have been identified, including human parvovirus B19-related ... Lau SK, Woo PC, Tse H, Fu CT, Au WK, Chen XC, Identification of novel porcine and bovine parvoviruses closely related to human ... Simmonds P, Douglas J, Bestetti G, Longhi E, Antinori S, Parravicini C, A third genotype of the human parvovirus PARV4 in sub- ... Biagini P, Dussol B, Touinssi M, Brunet P, Picard C, Moal V, Human parvovirus 4 in kidney transplant patients, France. Emerg ...
Parvovirus B19 causes an infection in humans only. Cat and dog parvoviruses do not infect humans. There is no vaccine available ... Parvovirus B19 infection may affect the development of arthritis. In adults (and perhaps some children), parvovirus B19 can ... neutropenia via parvovirus B19 reactivations, and even persistent parvovirus B19 infection. However, it is important to note ... Human parvovirus B19 is a non-enveloped, icosahedral virus that contains a single-stranded linear DNA genome of approximately ...
The cases of Parvovirus documented recently by the shelter have been from a large section of Santa Maria. Although Parvovirus ... Adult dogs should receive the Parvovirus vaccination as part of their yearly shot package. Treatment for the Parvovirus can be ... Parvovirus is specific to dogs and is not transmitted to humans or pets of a different species, such as cats. If you have any ... Parvovirus is most commonly seen in young puppies but can affect an unvaccinated dog of any age. ...
Although parvoviruses commonly cause disease in animals, it was only in 1975 that the first human pathogen of this family was ... Parvovirus B19 (B19V) is a single-stranded DNA virus of the family Parvoviridae and genus Erythrovirus. ... 13] Parvovirus B19 does not infect megakaryocytes; however, in vitro, parvovirus B19 proteins have a cytotoxic effect on ... Parvovirus B19 (B19V) is a single-stranded DNA virus of the family Parvoviridae and genus Erythrovirus. Although parvoviruses ...
... canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also ... Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid ... Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These ... 1 Department of Medicine, Center for Academic Research and Training in Anthropogeny, 9500 Gilman Drive, University of ...
Abstract Human parvovirus B19 (B19V) has a wide clinical spectrum, ranging from an asymptomatic infection to a life threatening ... Human parvovirus B19 (B19V) has a wide clinical spectrum, ranging from an asymptomatic infection to a life threatening one. ... Human parvovirus B19 (B19V) has a wide clinical spectrum, ranging from an asymptomatic infection to a life threatening one. ... An Outbreak of Parvovirus B19 in Israel - MDPI November 19, 2023, 11:09 PM. ...
B19 is in the genus parvovirus, which includes a number of animal parvoviruses such as the canine parvovirus and feline ... Human parvovirus and the fetus (Letter). Lancet 1985;2:1012. * Saarinen UA, Chorba TL, Tattersall P, et al. Human parvovirus ... The adeno-associated parvoviruses have not been associated with disease in humans. Fecal parvoviruses and the RA1 virus have ... The parvoviruses tend to be species-specific; only the adeno-associated parvoviruses (members of the dependovirus genus) and ...
Development of a Polymerase Chain Reaction Procedure for Detection of Chicken and Turkey Parvoviruses. ... In a nationwide survey, a total of 138 field enteric samples from poultry flocks were tested by PCR for parvovirus presence. Of ... For the first time, our data clearly demonstrate that parvoviruses are widely distributed in commercial poultry flocks in the ... The high prevalence of parvovirus infection in birds from enteric disease-affected flocks suggests a potential role of these ...
Four cases of RDD (two nodal sites and two extranodal upper respiratory tract sites) were analysed for parvovirus B19 (B19) ... Parvovirus B19 detected in Rosai-Dorfman disease in nodal and extranodal manifestations ... Parvovirus B19 detected in Rosai-Dorfman disease in nodal and extranodal manifestations ... 1Institute of Human Genetics, Saarland University, University Hospital, Homburg/Saar, Germany. ...
Testing and Diagnosis of Parvovirus. Available Tests for Diagnosing Parvovirus. To diagnose parvovirus, veterinarians often use ... Transmission of Parvovirus Between Dogs. Parvovirus can be transmitted directly or indirectly between dogs. Direct transmission ... The Truth About Parvovirus: Debunking Common Myths and Misconceptions. stopsmartmeters August 26, 2023 4 min read ... Canine parvovirus is a severe and life-threatening disease that primarily affects puppies, and its essential to understand the ...
Parvovirus B19 only infects humans and cannot be picked up from animals. It spreads from person-to-person. Parvovirus B19 virus ... Infection due to Parvovirus B19 can affect all age groups but is more common in children than adults. About 60% of adults have ... Parvovirus B19 causes slapped cheek syndrome which is usually a mild self-limiting viral illness and is very common in ... Parvovirus B19 is not a notifiable disease in Ireland, therefore laboratory test data from the National Virus Reference ...
Parvovirus (CPV). ~Parvovirus (CPV-2c). ~Distemper. ~Bordetella. ~Adenovirus type 1. ~Adenovirus type 2. ~Leptosporosis. ~ ...
Parvovirus B19. Parvovirus is a nonenveloped virus that is usually transmitted by the respiratory route and that eventually ... The spectrum of clinical results of parvovirus infection depends mainly on the immune status of the recipient. The parvovirus ... Parvovirus B19 transmission by a high-purity factor VIII concentrate. Transfusion. 2005 Jun. 45(6):1003-10. [QxMD MEDLINE Link] ... It is not effective against HAV and parvovirus; consequently, the blood product is tested for these 2 agents if the solvent- ...
Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry. Nature Communications. 2021 Jun 22;12( ... Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry. In: Nature Communications. 2021 ; Vol ... 1, 3834, 22.06.2021, p. 3834.. Research output: Contribution to journal › Article › Research › peer-review ... Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry. / Kulkarni, Amit; Ferreira, Tiago; ...
Home , Archives , Vol 65, No 3 (2020) , Results of a study of parvovirus B19 (Parvoviridae, Parvovirinae, Erythroparvovirus, ... Results of a study of parvovirus B19 (Parvoviridae, Parvovirinae, Erythroparvovirus, Primate erythroparvovirus 1) prevalence ... Keywords Bunyaviridae COVID-19 ELISA HIV HIV-1 Ixodidae SARS-CoV-2 antiviral activity hemagglutinin herpes simplex virus human ... Keywords Bunyaviridae COVID-19 ELISA HIV HIV-1 Ixodidae SARS-CoV-2 antiviral activity hemagglutinin herpes simplex virus human ...
Acute glomerulonephritis triggered by parvovirus B19. Tidsskr Nor Laegeforen. 2018 Oct 30. 138 (17):[QxMD MEDLINE Link]. ... The increase begins in 1-3 weeks, peaks in 3-5 weeks, and returns to normal in 6 months. ASO titer is unrelated to severity, ... alpha-1-microglobulin), may help predict the clinical outcome and may help in guiding steroid and immunosuppressive therapy, ...
Prevalence of canine parvovirus infection in Grand Tunis, Tunisia Ghada Tagorti 93-97 ...
Diverse hematologic effects of parvovirus B19 infection. Pediatr Clin North Am. 1996 Jun. 43(3):809-21. [QxMD MEDLINE Link]. ... 1] The nonmarginal pool constitutes only 4-5% of total body neutrophil stores; most of the neutrophils in the body are ... 1] Some cases may be genetically determined with an autosomal recessive inheritance. Other cases may be due to an autosomal ... Once the offending agent is stopped, neutrophil counts tend to recover within 1 week. Some drugs with significantly high risk ...
One group was given a dose of killed feline parvovirus vaccine at admission, and the other group was not given any vaccination ... Ena gruppen vaccinerades vid inskrivning med ett avdödat vaccin mot felint parvovirus, samt ytterligare en gång efter två ... Syftet med denna studie var att säkerställa huruvida vaccination mot felint parvovirus har någon signifikant skyddande effekt ... Does vaccination against Feline Parvovirus protect hospitalized raccoon kits from clinical outbreaks of parvoviral disease?. ...
The 2 cured patients were infected with B19 parvovirus and were treated with IFN-1β. Regarding complications, the patients ... the other 2 had inflammation with positive PCR for the B19 parvovirus in the myocardium and peripheral blood. Specific therapy ... 1]. A. Pollack, A.R. Kontorovich, V. Fuster, G.W. Dec.. Viral myocarditis-diagnosis, treatment options, and current ... Interferon-1β (IFN-1β) is a molecule secreted by immune system cells, mainly fibroblasts. Its serum levels are decreased in ...
Facility Disinfectant is an animal disinfectant that kills many of the most common dog and cat viruses including parvovirus. ... Canine Parvovirus Disinfection: Add 4 ounces of concentrated disinfectant to 1 gallon of water. Treated surfaces must remain ... Canine Parvovirus (CPV) (4 oz. per gallon). Canine Adenovirus. Canine Coronavirus. Canine Distemper. Canine Parainfluenza Virus ... Porcine Parvovirus (4 oz. per gallon). Porcine Rotavirus. Pseudorabies virus. Porcine Respiratory (PRRSV). Infectious Bovine ...
Parvovirus: odds of a puppy getting it? September 1, 2009. What caused the scars on the Dalai Lamas arm? February 7, 2008. ... So unfortunately this is a combination of 1. there are still a lot of unknowns about diseases and mechanisms within the body ... posted by Aleyn at 1:38 PM on June 3 [9 favorites] ...
Fairmont Park Dog Park Temporarily Closed Due to Canine Parvovirus Starting September 19, Riley County will temporarily close ... New Brush Truck now in service at RCFD#1 Konza Valley Station Say hello to Brush Truck #115! This (new to us) brush truck is ... 2024 Funding Riley County Fire District #1 This update aims to clear up any confusion caused by inaccurate information in a ... At midnight on the morning of July 5th, Riley County Fire District #1 was dispatched to 12261 Walnut Creek Rd. for a report of ...
Book Parvovirus Antibodies Elisa Blood @Home at Best Prices at the slot of your choice. View details of test: When to take, ... Parvovirus Antibodies test is performed on a sample of blood to measure the level of Parvovirus Antibodies - IgG and Parvovirus ... No special preparation is needed for Parvovirus Antibodies Elisa Blood. Inform your doctor if you are on any medications or ... the blood.It is performed to confirm Parvovirus Infection and also during the treatment and after the treatment of Parvovirus ...
The virulence of porcine circovirus type 2 (PCV2) isolated in Santa Catarina State by coinfection with porcine parvovirus (PPV ... Experimental coinfection of SPF pigs with porcine circovirus type 2 isolated in Brazil and porcine parvovirus Medicina ... A ivermectina acarretou menos (16,1%) efeitos colaterais em relação à moxidectina (37,5%) (P=0,03). As recidivas foram, ... Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Volume: 58, Issue: 1, Published: 2006 ...
PPV: Porcine Parvovirus. 11.1 Composition. The composition of Octagam 5% liquid is shown in table 8 as follows:. Table 8 : ... 1 INDICATIONS AND USAGE 1.1 Primary Humoral Immunodeficiency Diseases (PI) 2 DOSAGE AND ADMINISTRATION 2.1 Preparation and ... 97 Suppl 1, 79-83 (1994).. * Kannan, S., Rowland, C. H., Hockings, G. I. and Tauchmann, P. M. Intragam can interfere with blood ... IgG subclasses are fully represented with the following approximate percents of total IgG: IgG 1 is 65%, IgG 2 is 30%, IgG 3 is ...
Categories: Parvovirus Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 8 images ...
We found high, constant exposure to canine parvovirus (wolf seroprevalence: 100%; coyote: 94%), canine adenovirus-1 (wolf pups ... 0.5-0.9 yr]: 91%, adults [≥1 yr]: 96%; coyote juveniles [0.5-1.5 yrs]: 18%, adults [≥1.6 yrs]: 83%), and canine herpesvirus ( ...
While this antibody is at higher levels, it is able to neutralize viruses such as canine parvovirus and canine distemper virus ... A modified live canine parvovirus vaccine. II. Immune response. Cornell Veterinarian,1983 Jan; 73(1):13-29. ... had not had a nomograph completed for their dam were significantly less likely to be protected against distemper and parvovirus ...

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