One of the convolutions on the medial surface of the CEREBRAL HEMISPHERES. It surrounds the rostral part of the brain and CORPUS CALLOSUM and forms part of the LIMBIC SYSTEM.
GRAY MATTER situated above the GYRUS HIPPOCAMPI. It is composed of three layers. The molecular layer is continuous with the HIPPOCAMPUS in the hippocampal fissure. The granular layer consists of closely arranged spherical or oval neurons, called GRANULE CELLS, whose AXONS pass through the polymorphic layer ending on the DENDRITES of PYRAMIDAL CELLS in the hippocampus.
A convolution on the inferior surface of each cerebral hemisphere, lying between the hippocampal and collateral sulci.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A pathway of fibers that originates in the lateral part of the ENTORHINAL CORTEX, perforates the SUBICULUM of the HIPPOCAMPUS, and runs into the stratum moleculare of the hippocampus, where these fibers synapse with others that go to the DENTATE GYRUS where the pathway terminates. It is also known as the perforating fasciculus.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Upper central part of the cerebral hemisphere. It is located posterior to central sulcus, anterior to the OCCIPITAL LOBE, and superior to the TEMPORAL LOBES.
Axons of certain cells in the DENTATE GYRUS. They project to the polymorphic layer of the dentate gyrus and to the proximal dendrites of PYRAMIDAL CELLS of the HIPPOCAMPUS. These mossy fibers should not be confused with mossy fibers that are cerebellar afferents (see NERVE FIBERS).
A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.
Neural tracts connecting one part of the nervous system with another.
A verbal or nonverbal means of communicating ideas or feelings.
Dominance of one cerebral hemisphere over the other in cerebral functions.
The time from the onset of a stimulus until a response is observed.
A subsection of the hippocampus, described by Lorente de No, that is located between the HIPPOCAMPUS CA2 FIELD and the DENTATE GYRUS.
Posterior portion of the CEREBRAL HEMISPHERES responsible for processing visual sensory information. It is located posterior to the parieto-occipital sulcus and extends to the preoccipital notch.
Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.
The region of the cerebral cortex that receives the auditory radiation from the MEDIAL GENICULATE BODY.
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.
Use of sound to elicit a response in the nervous system.
The relationships between symbols and their meanings.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
Cerebral cortex region on the medial aspect of the PARAHIPPOCAMPAL GYRUS, immediately caudal to the OLFACTORY CORTEX of the uncus. The entorhinal cortex is the origin of the major neural fiber system afferent to the HIPPOCAMPAL FORMATION, the so-called PERFORANT PATHWAY.
The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain. (1/1403)

Morbidity and mortality from head trauma is highest among children. No animal model mimicking traumatic brain injury in children has yet been established, and the mechanisms of neuronal degeneration after traumatic injury to the developing brain are not understood. In infant rats subjected to percussion head trauma, two types of brain damage could be characterized. The first type or primary damage evolved within 4 hr and occurred by an excitotoxic mechanism. The second type or secondary damage evolved within 6-24 hr and occurred by an apoptotic mechanism. Primary damage remained localized to the parietal cortex at the site of impact. Secondary damage affected distant sites such as the cingulate/retrosplenial cortex, subiculum, frontal cortex, thalamus and striatum. Secondary apoptotic damage was more severe than primary excitotoxic damage. Morphometric analysis demonstrated that the N-methyl-D-aspartate receptor antagonists 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonate and dizocilpine protected against primary excitotoxic damage but increased severity of secondary apoptotic damage. 2-Sulfo-alpha-phenyl-N-tert-butyl-nitrone, a free radical scavenger, did not affect primary excitotoxic damage but mitigated apoptotic damage. These observations demonstrate that apoptosis and not excitotoxicity determine neuropathologic outcome after traumatic injury to the developing brain. Whereas free radical scavengers may prove useful in therapy of head trauma in children, N-methyl-D-aspartate antagonists should be avoided because of their propensity to increase severity of apoptotic damage.  (+info)

Blind smell: brain activation induced by an undetected air-borne chemical. (2/1403)

EEG and behavioural evidence suggests that air-borne chemicals can affect the nervous system without being consciously detected. EEG and behaviour, however, do not specify which brain structures are involved in chemical sensing that occurs below a threshold of conscious detection. Here we used functional MRI to localize brain activation induced by high and low concentrations of the air-borne compound oestra-1,3,5(10),16-tetraen-3yl acetate. Following presentations of both concentrations, eight of eight subjects reported verbally that they could not detect any odour (P = 0.004). Forced choice detection performed during the presentations revealed above-chance detection of the high concentration, but no better than chance detection of the low concentration compound. Both concentrations induced significant brain activation, primarily in the anterior medial thalamus and inferior frontal gyrus. Activation in the inferior frontal gyrus during the high concentration condition was significantly greater in the right than in the left hemisphere (P = 0.03). A trend towards greater thalamic activation was observed for the high concentration than the low concentration compound (P = 0.08). These findings localize human brain activation that was induced by an undetectable air-borne chemical (the low concentration compound).  (+info)

The role of ventral medial wall motor areas in bimanual co-ordination. A combined lesion and activation study. (3/1403)

Two patients with midline tumours and disturbances of bimanual co-ordination as the presenting symptoms were examined. Both reported difficulties whenever the two hands had to act together simultaneously, whereas they had no problems with unimanual dexterity or the use of both hands sequentially. In the first patient the lesion was confined to the cingulate gyrus; in the second it also invaded the corpus callosum and the supplementary motor area. Kinematic analysis of bimanual in-phase and anti-phase movements revealed an impairment of both the temporal adjustment between the hands and the independence of movements between the two hands. A functional imaging study in six volunteers, who performed the same bimanual in-phase and anti-phase tasks, showed strong activations of midline areas including the cingulate and ventral supplementary motor area. The prominent activation of the ventral medial wall motor areas in the volunteers in conjunction with the bimanual co-ordination disorder in the two patients with lesions compromising their function is evidence for their pivotal role in bimanual co-ordination.  (+info)

A PET study of sequential finger movements of varying length in patients with Parkinson's disease. (4/1403)

To study the difficulty that patients with Parkinson's disease have in performing long sequential movements, we used H2(15)O PET to assess the regional cerebral blood flow (rCBF) associated with the performance of simple repetitive movements, well-learned sequential finger movements of varying length and self-selected movements. Sequential finger movements in the Parkinson's disease patients were associated with an activation pattern similar to that found in normal subjects, but Parkinson's disease patients showed relative overactivity in the precuneus, premotor and parietal cortices. Increasing the complexity of movements resulted in increased rCBF in the premotor and parietal cortices of normal subjects; the Parkinson's disease patients showed greater increases in these same regions and had additional significant increases in the anterior supplementary motor area (SMA)/cingulate. Performance of self-selected movements induced significant activation of the anterior SMA/cingulate in normal subjects but not in Parkinson's disease patients. We conclude that in Parkinson's disease patients more cortical areas are recruited to perform sequential finger movements; this may be the result of increasing corticocortical activity to compensate for striatal dysfunction.  (+info)

Identification of the cerebral loci processing human swallowing with H2(15)O PET activation. (5/1403)

Lesional and electrophysiological data implicate a role for the cerebral cortex in the initiation and modulation of human swallowing, and yet its functional neuroanatomy remains undefined. We therefore conducted a functional study of the cerebral loci processing human volitional swallowing with 15O-labeled water positron emission tomography (PET) activation imaging. Regional cerebral activation was investigated in 8 healthy right handed male volunteers with a randomized 12-scan paradigm of rest and water swallows (5 ml/bolus, continuous infusion) at increasing frequencies of 0.1, 0.2, and 0.3 Hz, which were visually cued and monitored with submental electromyogram (EMG). Group and individual linear covariate analyses were performed with SPM96. In five of eight subjects, the cortical motor representation of pharynx was subsequently mapped with transcranial magnetic stimulation (TMS) in a posthoc manner to substantiate findings of hemispheric differences in sensorimotor cortex activation seen with PET. During swallowing, group PET analysis identified increased regional cerebral blood flow (rCBF) (P < 0.001) within bilateral caudolateral sensorimotor cortex [Brodmann's area (BA) 3, 4, and 6], right anterior insula (BA 16), right orbitofrontal and temporopolar cortex (BA 11 and 38), left mesial premotor cortex (BA 6 and 24), left temporopolar cortex and amygdala (BA 38 and 34), left superiomedial cerebellum, and dorsal brain stem. Decreased rCBF (P < 0.001) was also observed within bilateral posterior parietal cortex (BA 7), right anterior occipital cortex (BA 19), left superior frontal cortex (BA 8), right prefrontal cortex (BA 9), and bilateral superiomedial temporal cortex (BA 41 and 42). Individual PET analysis revealed asymmetric representation within sensorimotor cortex in six of eight subjects, four lateralizing to right hemisphere and two to left hemisphere. TMS mapping in the five subjects identified condordant interhemisphere asymmetries in the motor representation for pharynx, consistent with the PET findings. We conclude that volitional swallowing recruits multiple cerebral regions, in particular sensorimotor cortex, insula, temporopolar cortex, cerebellum, and brain stem, the sensorimotor cortex displaying strong degrees of interhemispheric asymmetry, further substantiated with TMS. Such findings may help explain the variable nature of swallowing disorders after stroke and other focal lesions to the cerebral cortex.  (+info)

Relation of impaired energy metabolism to apoptosis and necrosis following transient cerebral hypoxia-ischaemia. (6/1403)

This study investigated whether both mild and severe hypoxia-ischaemia (HI) caused significant numbers of cells to die by apoptosis in the developing brain in vivo. Newborn piglets were subjected to transient global HI and the fraction of all cells in the cingulate gyrus that were apoptotic or necrotic counted 48 h after resuscitation. The mean (S.D.) proportion of apoptotic cells was 11.9% (6.7%) (sham operated controls 4.1% (2.7%)), while 11.4% (8.4%) were necrotic (controls 0.7% (1.3%)) (P<0.05). Apoptotic and necrotic cell counts were both linearly related to the severity of impaired cerebral energy metabolism measured by magnetic resonance spectroscopy (P<0.05), as shown by: (1) the decline in the ratio of nucleotide triphosphates to the exchangeable phosphate pool during HI; (2) the fall in the ratio of phosphocreatine to inorganic phosphate 8 - 48 h after HI; and (3) an increased ratio of lactate to total creatine at both these times. Thus both apoptosis and necrosis occurred in the cingulate gyrus after both severe and mild HI in vivo in proportion to the severity of the insult.  (+info)

The effect of age on odor-stimulated functional MR imaging. (7/1403)

BACKGROUND AND PURPOSE: The effects of age, sex, and handedness on olfaction have not been adequately addressed with odor-stimulated functional MR imaging studies. We sought to determine the effect of age on functional MR imaging experiments performed with odor stimulation. METHODS: Five right-handed subjects with a mean age of 73 years and five right-handed subjects with a mean age of 24 years underwent gradient-echo echo-planar functional MR imaging using binasal olfactory stimulation. Imaging parameters included 3000/30 (TR/TE) and a 5-mm section thickness in a 6-minute sequence with 30 seconds of pulsed odorants alternating with 30 seconds of room air. The data were normalized to a standard atlas, and individual and group statistical parametric maps (SPMs) were generated for each task. The SPMs were thresholded for a P < .01, and the volumes of activation and distribution of cluster maxima were compared for the two groups. RESULTS: Analysis of the group SPMs revealed activated voxels in the frontal lobes, perisylvian regions, and cingulate gyri, with greater volume in the younger group than in the older group. The right inferior frontal, right perisylvian, and right and left cingulum had the largest number of voxels activated. The most common sites of activation on individual maps in both groups were the right inferior frontal regions and the right and left superior frontal and perisylvian zones. CONCLUSION: Given similar olfactory task paradigms, younger subjects showed a greater number of activated voxels than did older subjects. One must be cognizant of this effect when designing studies of odor-stimulated functional MR imaging.  (+info)

A large-scale distributed network for covert spatial attention: further anatomical delineation based on stringent behavioural and cognitive controls. (8/1403)

Functional MRI was used to examine cerebral activations in 12 subjects while they performed a spatial attention task. This study applied more stringent behavioural and cognitive controls than previously used for similar experiments: (i) subjects were included only if they showed evidence of attentional shifts while performing the task in the magnet; (ii) the experimental task and baseline condition were designed to eliminate the contributions of motor output, visual fixation, inhibition of eye movements, working memory and the conditional (no-go) component of responding. Activations were seen in all three hypothesized cortical epicentres forming a network for spatial attention: the lateral premotor cortex (frontal eye fields), the posterior parietal cortex and the cingulate cortex. Subcortical activations were seen in the basal ganglia and the thalamus. Although the task required attention to be equally shifted to the left and to the right, eight of 10 subjects showed a greater area of activation in the right parietal cortex, consistent with the specialization of the right hemisphere for spatial attention. Other areas of significant activation included the posterior temporo-occipital cortex and the anterior insula. The temporo-occipital activation was within a region broadly defined as MT+ (where MT is the middle temporal area) which contains the human equivalent of area MT in the macaque monkey. This temporo-occipital area appears to constitute a major component of the functional network activated by this spatial attention task. Its activation may reflect the 'inferred' shift of the attentional focus across the visual scene.  (+info)

Author(s): Connolly, CG; Wu, J; Ho, TC; Hoeft, F; Wolkowitz, O; Eisendrath, S; Frank, G; Hendren, R; Max, JE; Paulus, MP; Tapert, SF; Banerjee, D; Simmons, AN; Yang, TT | Abstract: Background Very few studies have been performed to understand the underlying neural substrates of adolescent major depressive disorder (MDD). Studies in depressed adults have demonstrated that the subgenual anterior cingulate cortex (sgACC) plays a pivotal role in depression and have revealed aberrant patterns of resting-state functional connectivity (RSFC). Here, we examine the RSFC of the sgACC in medication-naïve first-episode adolescents with MDD. Methods Twenty-three adolescents with MDD and 36 well-matched control subjects underwent functional magnetic resonance imaging to assess the RSFC of the sgACC. Results We observed elevated connectivity between the sgACC and the insula and between the sgACC and the amygdala in the MDD group compared with the control subjects. Decreased connectivity between the sgACC and the
The cingulate sulcus is a sulcus (brain fold) on the medial wall of the cerebral cortex. The frontal and parietal lobes are separated by the cingulate sulcus from the cingulate gyrus. [WP,unvetted]. [ http://en.wikipedia.org/wiki/Cingulate_sulcus ...
The anterior cingulate cortex has cognitive and affective divisions that are separable both anatomically and functionally.2 Previous studies in healthy individuals have shown that the affective division of the anterior cingulate cortex is activated by a number of emotional manipulations2,23 and our data in healthy participants confirm the findings of Whalen et al,4 who used an emotional counting Stroop to demonstrate increased activation in the pregenual region of the affective subdivision of the anterior cingulate cortex in response to emotional relative to neutral words. Also, in agreement with Whalen et al, we found that the emotional counting Stroop task was associated with an overall deactivation in this subdivision compared with fixation but that the deactivation was relatively less during presentation of emotional words. It has been suggested that the overall deactivation of the affective subdivision of the anterior cingulate cortex in response to the emotional counting Stroop reflects ...
In the human this area is known as ventral anterior cingulate area 24, and it refers to a subdivision of the cytoarchitecturally defined cingulate region of cerebral cortex (area cingularis anterior ventralis). It occupies most of the anterior cingulate gyrus in an arc around the genu of corpus callosum. Its outer border corresponds approximately to the cingulate sulcus. Cytoarchitecturally it is bounded internally by the pregenual area 33, externally by the dorsal anterior cingulate area 32, and caudally by the ventral posterior cingulate area 23 and the dorsal posterior cingulate area 31. Francis Crick, one of the discoverers of DNA, listed area 24 as the seat of free will because of its centrality in abulia and amotivational syndromes. ...
The posterior cingulate cortex exhibits connectivity with a wide range of intrinsic control networks. Its most widely known role is as a central node in the default mode network (DMN). The default mode network (and the PCC) is highly reactive and quickly deactivates during tasks with externally directed, or presently centered, attention (such as working memory or meditation).[4][8] Conversely, the DMN is active when attention is internally directed (during episodic memory retrieval, planning, and daydreaming). A failure of the DMN to deactivate at proper times is associated with poor cognitive function, thereby indicating its importance in attention.[4] In addition to the default mode network, the posterior cingulate cortex is also involved in the dorsal attention network (a top-down control of visual attention and eye movement) and the frontoparietal control network (involved in executive motor control).[4] Furthermore, fMRI studies have shown that the posterior cingulate cortex activates ...
en] OBJECTIVES: The aim of this study was to investigate the relationship between medial cortical activation and the presence of self and consciousness in healthy subjects and patients with vegetative state and minimally conscious state using functional magnetic resonance imaging (fMRI). EXPERIMENT DESIGN: We first conducted two fMRI experiments in healthy subjects to identify brain regions specifically associated with self-perception through the use of different auditory stimuli that had different grades of self-relatedness. We then applied these regions as functional localizers to examine the relationship between neural activity changes during self-relatedness and consciousness level in the patients with disorders of consciousness (DOC). PRINCIPAL OBSERVATIONS: We demonstrated recruitment of various anterior medial cortical regions including the anterior cingulate cortex (ACC) in healthy subjects during auditory perception of self-related stimuli. We further showed that patients with DOC ...
In our event-related functional magnetic resonance imaging (fMRI) experiment, participants learned to select between two response options by trial-and-error, using feedback stimuli that indicated monetary gains and losses. The results of the experiment indicate that error responses and error feedback activate the same region of dorsal anterior cingulate cortex, suggesting that this region is sensitive to both internal and external sources of error information.
A neuroimaging study reveals city dwellers who live closer to forests were more likely to have healthier amygdala structure and were better able to deal with stressful situations.... Read More... ...
Several studies have shown that ERK in the ACC is activated and contributes to the affective aspect in the inflammatory and phantom pain.14,24 Similarly, the current study also found that the incision resulted in ERK activation in the ACC. However, the incision-evoked ERK activation is biphasic and different from those in inflammatory pain or neuropathic pain. The activation pattern of p-ERK in formalin-induced inflammatory pain is still not fully determined. In a recent study by Wei and Zhuo, p-ERK in the ACC was observed to be transiently up-regulated in the formalin test.24 However, a more recent study reported the persistent up-regulation of p-ERK up to 24 h in the rostral ACC after formalin hind paw injection.14 The different expression profiles of p-ERK in the ACC in these two studies may be due to the different time courses (90 min vs. 24 h) and subregions of ACC. Notably, rostral ACC is closely associated with pain-related negative affect because destruction of neurons originating from ...
Sensory information processing in ACC networks is critical for ACC-related brain functions. Using in vivo whole-cell recording, we have investigated MP responses of layer II/III ACC neurons to sensory stimulation. We first found that ~54 % ACC neurons exhibited subthreshold or suprathreshold excitatory MP responses to a flash visual stimulus, which were largely dependent on neuronal activity in the visual thalamus but not visual cortex. We further found in an even larger population (~81 %) of ACC neurons that excitatory MP responses could also be evoked by a pain-related electrical stimulus. These findings may reflect potential mechanisms underlying the ACC function that involves information processing of sensory and noxious stimuli.. As a multimodal brain region, ACC has been known to be capable of responding to complex stimulation or tasks, including those related to reward [21-23] and aversive stimuli [7, 24-26] as well as attention [1, 9, 10, 27]. However, ACC neuronal activity in response ...
Reversible deactivation of the dorsal anterior cingulate cortex - an area of the cognitive control network - impairs rule maintenance but not rule switching per se, and disrupts task-related oscillatory activities in the dorsolateral prefrontal cortex - another area of the same network.
Activity in anterior cingulate cortex (ACC) has been linked both to commitment to a course of action, even when it is associated with costs, and to exploring or searching for alternative courses of action. Here we review evidence that this is due to the presence of multiple signals in ACC reflecting the updating of beliefs and internal models of the environment and encoding aspects of choice value, including the average value of choices afforded by the environment (search value). We contrast this evidence with the influential view that ACC activity is better described as reflecting task difficulty. A consideration of cortical neural network properties explains why ACC may carry such signals and also exhibit sensitivity to task difficulty.
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Overactivity in the subgenual anterior cingulate cortex underlies several key symptoms of depression, anxiety, and heart disease.
It is unclear whether r-IFC influences STN directly or via the preSMA. In our tract strength multiple regression analysis, tracts between r-IFC and r-STN were not significant predictors of SSRT, whereas the parameter estimates for tracts between preSMA and anatomically defined STN were significant (Table 2). Our results complement and extend on two recent reports in young adults (Forstmann et al., 2012; King et al., 2012). r-IFC-STN tract strength was also found to have no relationship with SSRT by Forstmann et al. (2012). Interestingly, they failed to find a relationship with preSMA-STN tract strength, instead reporting that the strength of the tract between anterior cingulate cortex (ACC) and STN predicts stopping ability. The reason for this discrepancy is unclear. Whereas preSMA has been associated specifically with the successful inhibition of a motor response, ACC activation is often reported for unsuccessful stop trials (Sharp et al., 2010). A tract strength analysis was not reported in ...
1) Feeling sick is a complex combination of events that may arise from damaged peripheral tissues as well as from their modulation by psychosocial factors. Therefore, the clinician must consider a symptom not so much as a single and isolated entity, but rather within the psychological and social context of the patient. The mere assessment of peripheral tissue damage considers bottom-up processes only, without taking the top-down modulation into consideration. 2) Interoceptive sensibility is at the very heart of the process of feeling sick. Whereas usually internal organs are not perceived in normal conditions, they may get access to consciousness in particular circumstances. This is due to the activation of receptors that project to a variety of subcortical and cortical regions. For example, several areas of the cerebral cortex are activated by interoceptive stimuli arising from the gastrointestinal and cardiovascular systems. 3) The insular cortex and the anterior cingulate cortex are key ...
This human study is based on an established cohort of SuperAgers, 80+-year-old individuals with episodic memory function at a level equal to, or better than, individuals 20-30 years younger. A preliminary investigation using structural brain imaging revealed a region of anterior cingulate cortex that was thicker in SuperAgers compared with healthy 50- to 65-year-olds. Here, we investigated the in vivo structural features of cingulate cortex in a larger sample of SuperAgers and conducted a histologic analysis of this region in postmortem specimens. A region-of-interest MRI structural analysis found cingulate cortex to be thinner in cognitively average 80+ year olds (n = 21) than in the healthy middle-aged group (n = 18). A region of the anterior cingulate cortex in the right hemisphere displayed greater thickness in SuperAgers (n = 31) compared with cognitively average 80+ year olds and also to the much younger healthy 50-60 year olds (p , 0.01). Postmortem investigations were conducted in the ...
One intriguing finding from brain scanning research is that a brain area called the anterior cingulate gyrus in the frontal lobes, slightly above the level of the eyes, lights up with activity when subjects perform active, intentional information processing of any type (Posner, 1993). This suggests the existence of a command circuit that controls and allocates attention. Perhaps this is the location of the executive process cognitive psychologists like to talk about...what most people identify as their conscious self, the origin of their willpower.. What abilities are correlated with activity in the anterior cingulate gyrus?. Posner pointed out that the anterior cingulate gyrus evolved relatively recently in the human species. It allows comprehensive forward planning in the human species. Posner suggested that comprehensive forward planning emerged about 60,000-100,000 years ago, about the same time modern humans emerged from Africa according to DNA-based theories of human origins.. Nicely ...
One group was placed inside a Magnetic Resonance Imaging (MRI) scanner where they were able to watch their brain activity on a moment-by-moment basis. They were then shown live action images of their rostral anterior cingulate cortex, an area of the brain responsible for processing pain. Next, they were given various mental strategies to try to train the brain to respond to pain differently, such as being asked to think of it as a relatively pleasant experience ...
This study is comparing the efficacy and effects of vilazodone with citalopram in female patients with major depressive disorder (anxious/unipolar depression).
BACKGROUND: We previously found that children of parents with depression showed impaired performance on a task of emotional categorisation. AIMS: To test the hypothesis that children of parents with depression would show abnormal neural responses in the anterior cingulate cortex, a brain region involved in the integration of emotional and cognitive information. METHOD: Eighteen young people (mean age 19.8 years) with no personal history of depression but with a biological parent with a history of major depression (FH+ participants) and 16 controls (mean age 19.9 years) underwent functional magnetic resonance imaging while completing an emotional counting Stroop task. RESULTS: Controls showed significant activation in the pregenual anterior cingulate cortex to both positive and negative words during the emotional Stroop task. This activation was absent in FH+ participants. CONCLUSIONS: Our findings show that people at increased familial risk of depression demonstrate impaired modulation of the anterior
Using a three-dimensional magnetic resonance imaging procedure to measure the volume of the rostral anterior cingulate gyrus (perigenual cingulate gyrus), Takahashi et al. (2003) found that the rostral anterior cingulate gyrus is larger in control (healthy) females than males, but this sex difference was not found in schizophrenic patients. Schizophrenic patients also had a smaller volume of perigenual cingulate gyrus than control subjects.[16] Haznedar et al. (2004) studied metabolic rate of glucose in anterior and posterior cingulate gyrus in patients with schizophrenia, schizotypal personality disorder (SPD) and compared them with a control group. The metabolic rate of glucose was found to be lower in the left anterior cingulate gyrus and the right posterior cingulate gyrus in patients with schizophrenia relative to controls. Although SPD patients were expected to show a glucose metabolic rate somewhere between the schizophrenic and controls, they actually had higher metabolic glucose rate in ...
TY - JOUR. T1 - Topography of claustrum and insula projections to medial prefrontal and anterior cingulate cortices of the common marmoset (Callithrix jacchus). AU - Reser, David H.. AU - Majka, Piotr. AU - Snell, Shakira. AU - Chan, Jonathan M.H.. AU - Watkins, Kirsty. AU - Worthy, Katrina. AU - Del Mar Quiroga, Maria. AU - Rosa, Marcello G.P.. PY - 2017/4/15. Y1 - 2017/4/15. N2 - The claustrum has been the subject of intense research interest in recent years, driven in large part by its extensive connections with various regions of the cerebral cortex and by hypotheses surrounding its possible role in multimodal sensory and/or sensory-emotional integration. Here we employed neuroanatomical tracers to map projections from the claustrum-insular region to the medial prefrontal and anterior cingulate cortex of the common marmoset (Callithrx jacchus). These areas were selected based on their identification as hub areas of the default mode and cortical salience networks, respectively. ...
Our ability to have an experience of anothers pain is characteristic of empathy. Using functional imaging, we assessed brain activity while volunteers experienced a painful stimulus and compared it to that elicited when they observed a signal indicating that their loved one-present in the same room-was receiving a similar pain stimulus. Bilateral anterior insula (AI), rostral anterior cingulate cortex (ACC), brainstem, and cerebellum were activated when subjects received pain and also by a signal that a loved one experienced pain. AIand ACC activation correlated with individual empathy scores. Activity in the posterior insula/secondary somatosensory cortex, the sensorimotor cortex (SI/MI), and the caudal ACC was specific to receiving pain. Thus, a neural response in AIand rostral ACC, activated in common for self and other conditions, suggests that the neural substrate for empathic experience does not involve the entire pain matrix. We conclude that only that part of the pain network ...
Functional magnetic resonance imaging studies (fMRI) have transformed our understanding of central processing of evoked pain but the typically used block and event-related designs are not best suited to the study of ongoing pain. Here we used arterial spin labelling (ASL) for cerebral blood flow mapping to characterise the neural correlates of perceived intensity of osteoarthritis (OA) pain and its interrelation with negative affect. Twenty-six patients with painful knee OA and twenty-seven healthy controls underwent pain phenotyping and ASL MRI at 3T. Intensity of OA pain correlated positively with blood flow in the anterior mid-cingulate cortex (aMCC), subgenual cingulate cortex (sgACC), bilateral hippocampi, bilateral amygdala, left central operculum, mid-insula, putamen and the brainstem. Additional control for trait anxiety scores reduced the pain-CBF association to the aMCC, whilst pain catastrophizing scores only explained some of the limbic correlations. In conclusion, we found that ...
The salience network (SN) plays a central role in cognitive control by integrating sensory input to guide attention, attend to motivationally salient stimuli, and recruit appropriate functional brain-behavior networks to modulate behavior. Mounting evidence suggests that disturbances in SN function underlie abnormalities in cognitive control and may be a common etiology underlying many psychiatric disorders. Such functional and anatomical abnormalities have been recently apparent in studies and meta-analyses of psychiatric illness using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM). Of particular importance, abnormal structure and function in major cortical nodes of the SN, the dorsal anterior cingulate cortex (dACC) and anterior insula (AI), have been observed as a common neurobiological substrate across a broad spectrum of psychiatric disorders. In addition to cortical nodes of the SN, the networks associated subcortical structures, including the dorsal striatum,
Functional human brain imaging studies have indicated the essential role of cortical regions, such as the anterior cingulate cortex (ACC), in romantic love and sex. However, the neurobiological basis...
There is good evidence that TM produces a sense of well-being in recipients and there are also studies suggesting that TM may also produce effects on blood pressure and heart rate as well as upon psychological emotions such as anxiety [24, 34-37]. An advantage of the cross-over design used here is that the individuals act as their own controls, and the first author of the present study has previously used this model, with a similar sample size (22 individuals) to demonstrate changes in heart rate and heart rate variability following TM [36]. In the present study, an effect on the perceived pleasantness rating scale for TM was observed. This is consistent with a previous study from the first author, who showed that the increased level of perceived pleasantness was associated with an increased blood flow in the pregenual anterior cingulate cortex [24], a brain region that is activated by pleasurable stimuli [38]. In contrast, effects upon the state arm of the STAI-Y scale over and above that seen ...
OBJECTIVE. Insulin resistance (IR) confers risk for Type 2 diabetes and is associated with depressed mood. Neurons within the ventral striatum (VS) are sensitive to insulin levels and show altered function in the context of both IR and depression. Hence, VS may represent a critical component of a neural circuitry linking IR to depressed mood.. METHODS. Ninety adults (aged 30-50 years) free from major psychiatric illnesses and diabetes participated. Fasting blood was sampled, and participants completed a set of questionnaires (including the Beck Depression Inventory-II). Participants also underwent resting-state functional magnetic resonance imaging of the brain. Seed-based connectivity analyses, centered on VS, were conducted to examine how resting-state interregional connectivity patterns covaried with IR and depressed mood.. RESULTS. Higher levels of IR covaried with increased connective strength between the left VS and two regions: the insula and the anterior midcingulate cortex (aMCC). ...
Functional magnetic resonance imaging was used to investigate activation patterns within the cingulate region during tasks based on spatial attention. Subjects were asked to detect targets which appeared either at the site indicated by a cue or on the opposite side. A cue effect was identified by the presence of shorter reaction times to validly than invalidly cued targets, showing that an anticipatory bias had been generated in the direction of the cue. Target detection accuracy was consistently above 90% although cue effects and reaction times displayed substantial variations, from one task session to another. Activation within the anterior cingulate region was seen in 16 of the 26 sessions but showed no correlation with reaction time. Posterior cingulate activation was seen in only 6 of the 26 sessions. However, a random effects analysis showed that the task-related signal change in this region was strongly correlated with the speed of target detection. A post hoc analysis indicated that this
Life satisfaction is a component of subjective well-being that reflects a global judgement of the quality of life according to an individuals own ne
Figuring out how the brain decides between two options is difficult. This is especially true for the human brain, whose activity is typically accessible only via the small and occasionally distorted window provided by new imaging technologies (such as functional MRI (fMRI)).. In contrast, it is typically more accurate to observe monkey brains since the skull can be opened and brain activity recorded directly.. Despite this, if you were to look just at the human research, you would consider it a fact that the anterior cingulate cortex (ACC) increases its activity during response conflict. The thought is that this brain region detects that you are having trouble making decisions, and signals other brain regions to pay more attention.. If you were to only look at research with monkeys, however, you would think otherwise. No research with macaque monkeys (the non-human primate typically used in neuroscience research) has found conflict activity in ACC.. My most recent publication looks at two ...
Of the 148 healthy individuals, 75 remained stable, while 73 deteriorated cognitively at 18 months clinical follow-up. Those who deteriorated had shown reduced perfusion at their baseline ASL MRI exams, particularly in the posterior cingulate cortex, an area in the middle of the brain that is associated with the default mode network, the neural network that is active when the brain is not concentrating on a specific task. Declines in this network are seen in MCI patients and are more pronounced in those with Alzheimers disease.. The pattern of reduced perfusion in the brains of healthy individuals who went on to develop cognitive deficits was similar to that of patients with MCI.. There is a known close link between neural activity and brain perfusion in the posterior cingulate cortex, Dr. Haller said. Less perfusion indicates decreased neural activity.. The results suggest that individuals with decreased perfusion detected with ASL MRI may temporarily maintain their cognitive status ...
Hypotheses 1 & 2 predict that following 6 weeks of treatment with lithium or quetiapine, manic adolescents who demonstrate symptomatic improvement will exhibit normalized (decreased) VLPFC and ACC activation and increased activation of compensatory posterior attentional brain areas as well as normalization of VLPFC and ACC neurometabolite measures (increased NAA and decreased Glu levels) compared with those who do not experience symptomatic improvement and healthy adolescents.. Hypothesis 3 predicts significant associations between fMRI activation changes (i.e. decreased activation in VLPFC and ACC ROIs and increased activation in the posterior attention ROI) and MRS changes (increases in NAA and decreases in Glu levels in the VLPFC and ACC) for patients who exhibit symptomatic improvement with either treatment.. Hypothesis 4 predicts that decreases in mI levels at 1 week will be associated with lithium, but not quetiapine, response at endpoint.. In contrast, Hypothesis 5 predicts higher ...
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Functional magnetic resonance imaging at 7.0 Tesla was undertaken among Schizophrenia participants (Sz), and clinical (major mood disorder; MDD) and healthy controls (HC), during performance of the Stoop task. Stroop conditions included congruent and incongruent word color items, color-only items, and word-only items. Previous modeling results extended to this most widely used selective-attention task. All groups executed item-encoding operations (subprocesses of the item encoding process) at the same rate (performance accuracy being similarly high throughout), thus displaying like processing capacity; Sz participants, however, employed more subprocesses for item completions than did the MDD participants, who in turn used more subprocesses than the HC group. The reduced efficiency in deploying cognitive-workload capacity among the Sz participants was paralleled by more diffuse neuroconnectivity (Blood-Oxygen-Level-Dependent co-activation) with the anterior cingulate cortex (Broadman Area 32), spreading
achtergrond In de afgelopen jaren zijn er verschillende neuromodulatietechnieken geïntroduceerd als interventie voor verslaving. doel Overzicht geven van onderzoeken die zijn uitgevoerd naar elektro-encefalografie(eeg)- en real-time-functionele-mri (rt-fmri)-neurofeedback, transcraniële magnetische stimulatie (tms), transcraniële gelijkstroomstimulatie (tdcs) en diepe hersenstimulatie (dhs) bij verslaving. methode Literatuuronderzoek met bijzondere aandacht voor Nederlandse studies. resultaten Studies met eeg-neurofeedback laten effecten zien op gebruik, therapietrouw en cue-reactiviteit bij cocaïne- en alcoholafhankelijkheid. Een pilotstudie naar de effecten van fmri-neurofeedback laat zien dat modulatie van de gyrus cinguli anterior leidde tot een verminderde craving bij rokers. Verschillende studies laten een afname van craving zien bij alcoholafhankelijken na stimulatie met tms of tdcs van de gyrus cinguli anterior of de dorsolaterale prefrontale cortex. De eerste dhs-pilotstudies ...
Dr. Medallas work combines cellular in vitro electrophysiological methods with multi-scale anatomic techniques to understand the biophysical and synaptic properties of neurons within prefrontal cortical (PFC) networks in non-human primate and rodent animal models. Her expertise includes patch-clamp recording, pathway tract-tracing, multiple immunohistochemical labeling techniques for light and electron microscopy (EM), 3D serial EM, and confocal microscopy. The major goal of her work is to understand how distinct limbic, sensory and motor networks interact and are controlled by the PFC - the central executive of the brain. Her current focus is on the medial prefrontal anterior cingulate cortex (ACC) in rhesus monkeys, an area important for attention, emotions and context-to-action transformations, and is selectively disrupted in many affective disorders such as depression and anxiety disorders.. ...
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The ability to form positive mental images may be an important aspect of mental health and wellbeing. We have previously demonstrated that the vividness of positive prospective imagery is increased in healthy older adults following positive imagery cognitive training. The rostral anterior cingulate cortex (rACC) is involved in the simulation of future affective episodes. Here we investigate the effect of positive imagery training on rACC activity during the imagination of novel, ambiguous scenarios versus closely matched control training. Seventy-five participants received 4-weeks of positive imagery or control training. Participants underwent an fMRI scan, during which they completed an Ambiguous Sentences Task, which required them to form mental images in response to cues describing ambiguous social events. rACC activity was positively correlated with the pleasantness ratings of images formed. Positive imagery training increased rACC and bilateral hippocampal activity compared with the control
Both the anterior cingulate cortex (ACC) and mesolimbic dopamine, particularly in the nucleus accumbens (NAc), have been implicated in allowing an animal to overcome effort constraints to obtain greater benefits. However, their exact contribution to such decisions has, to date, never been directly compared. To investigate this issue we tested rats on an operant effort-related cost-benefit decision-making task where animals selected between two response alternatives, one of which involved investing effort by lever pressing on a high fixed-ratio (FR) schedule to gain high reward [four food pellets (HR)], whereas the other led to a small amount of food on an FR schedule entailing less energetic cost [two food pellets, low reward (LR)]. All animals initially preferred to put in work to gain the HR. Systemic administration of a D2 antagonist caused a significant switch in choices towards the LR option. Similarly, post-operatively, excitotoxic ACC lesions caused a significant bias away from HR choices
Obsessive-compulsive disorder (OCD) is a relatively common and disabling psychiatric disorder whose pathophysiology is incompletely understood. In this study, we utilized magnetic resonance spectroscopy (MRS) in an effort to provide a better understanding of the role of brain gamma-aminobutyric acid (GABA) and glutamate in the pathophysiology of OCD. We hypothesized that beyond the separate effects of these neurotransmitter systems, a disruption in the balance between GABA and glutamate could be particularly relevant to OCD. We obtained MRS measures of GABA and glutamate concentrations in the anterior cingulate cortex from 23 adult patients with OCD and 20 sex- and age-matched healthy community volunteers. Established clinical rating scales were used to assess the severities of OCD, anxiety, and depression symptoms. Statistical analysis involved the assessment of patient-control group differences in the individual measures of GABA and glutamate, as well as in the ratio of the GABA to glutamate measures.
For the study, Spiegel and his Stanford colleagues performed functional and structural MRI scans of the brains of 12 adults with high hypnotizability and 12 adults with low hypnotizability.. The researchers looked at the activity of three different networks in the brain: the default-mode network, used when ones brain is idle; the executive-control network, which is involved in making decisions; and the salience network, which is involved in deciding something is more important than something else.. The findings, Spiegel said, were clear: Both groups had an active default-mode network, but highly hypnotizable participants showed greater co-activation between components of the executive-control network and the salience network. More specifically, in the brains of the highly hypnotizable group the left dorsolateral prefrontal cortex, an executive-control region of the brain, appeared to be activated in tandem with the dorsal anterior cingulate cortex, which is part of the salience network and ...
Figure 10. Epilepsia, 25(7), 906 843. Both types are reported to cause or the nucleus accumbens of alcohol-naive alcohol-preferring compared to its proximity to the thalamus (light blue). *p < 0. 01 versus the human anterior cingulate cortex and psychostimulant abuse: Studies in which case the term personality has been unsuccessful. 2. Tissue congestion of the families of nachrs is involved in more recent reports in literature concerning the expression of proteins located in the rat brain. Also, in a later phase occurring almost exclusively in a. Emotional impairment after right hepatectomy: Global and segmental colonic resection for benign disease, women receiving routine examinations. The tasks were designed to obtain the help of com-parative neuroanatomy, however, fossils can be detected by gradient echo (gre) and t4w images. Collagenous colitis, enteropathic arthritis, and healthy controls or patients with pd. Asterisks (*) indicate statistically significant changes in human mothers. The ...
TY - JOUR. T1 - NMDA receptors in retrosplenial cortex are necessary for retrieval of recent and remote context fear memory. AU - Corcoran, Kevin A.. AU - Donnan, Michael D.. AU - Tronson, Natalie C.. AU - Guzmán, Yomayra F.. AU - Gao, Can. AU - Jovasevic, Vladimir. AU - Guedea, Anita L.. AU - Radulovic, Jelena. PY - 2011/8/10. Y1 - 2011/8/10. N2 - Over time, memory retrieval is thought to transfer from the hippocampus to a distributed network of neocortical sites. Of these sites, the retrosplenial cortex (RSC) is robustly activated during retrieval of remotely acquired, emotionally valenced memories. It is unclear, however, whether RSC is specifically involved in memory storage or retrieval, and which neurotransmitter receptor mechanisms serve its function.Weaddressed these questions by inhibiting NMDARs in RSC via infusions of APV before tests for context fear in mice. Anterior cingulate cortex (ACC) and dorsal hippocampus (DH), which have been implicated in the retrieval of remote and recent ...
Basaria S, Jasuja R, Huang G, Wharton W, Pan H, Pencina K, Li Z, Travison T, Bhawan J, Gonthier R, Labrie F, Dury A, Serra C, Papazian A, Leary M, Amr S, Storer T, Stern E*, Bhasin S*. Characteristics of Men Who Report Persistent Sexual Symptoms after Finasteride Use for Hair Loss, Journ Clin Endocr Metab (in press). *shared Senior Authors. Protopopescu X, Pan H, Tuescher O, Root J, Cheng L, Altemus M, Polanecsky M, McEwen B, Stern E, Silbersweig D. Toward a functional neuroanatomy of premenstrual dysphoric disorder: differential amygdalar, orbitofrontal and ventral striatal activity. J Affective Disorders, 108: 87-94, 2008.. Protopopescu X, Butler T, Pan H, Altemus A, Polanescsky M, McEwen B, Silbersweig E, Stern E. Hippocampal structural changes across the menstrual cycle. Hippocampus, 18:985-8, 2008.. Butler T, Imperato-McGinley j, Pan H, Voyer D, Cunningham-Bussel AC, Chang L, Zhu Y-S, Cordero J, Stern E, Silbersweig D. Sex specificity of ventral anterior cingulate cortex suppression during ...
Abstract-Some meditation techniques teach the practitioner to achieve the state of mental silence. The aim ofthis study was to investigate brain regions that are associated with their volume and functional connectivity(FC) with the depth of mental silence in long-term practitioners of Sahaja Yoga Meditation. Twenty-three long-term practitioners of this meditation were scanned using Magnetic Resonance Imaging. In order to identify theneural correlates of the depth of mental silence, we tested which gray matter volumes (GMV) were correlated withthe depth of mental silence and which regions these areas were functionally connected to under a meditation con-dition. GMV in medial prefrontal cortex including rostral anterior cingulate cortex were positively correlated withthe subjective perception of the depth of mental silence inside the scanner. Furthermore, there was significantlyincreased FC between this area and bilateral anterior insula/putamen during a meditation-state specifically, ...
The third type, reflexive movement, is a fast, protective mechanism, which generally occurs before the brain is informed of the situation. Instead of the sensory neurons contacting the brain to obtain a command, these signals pass directly to interneurons in the spinal column and from there back out to the muscles, thereby avoiding the delay which would result from contacting the brain to obtain a response. This is of course how the classic knee-jerk reaction works. The interneurons are linked together into networks. The signal may also be passed to the brain to become conscious.. The anterior cingulate cortex (ACC) compares plans to how things are really happening in order to correct for errors or trouble due to unforeseen circumstances. It also monitors progress towards goals. It is connected to the lateral prefrontal cortex, giving it access to working memory.. We will not look any deeper on the subject of motor control. So lets go study how learning and memory take place.. ...
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... supramarginalis Angular gyrus, lat. gyrus angularis Cingulate gyrus lat. gyrus cinguli Fornicate gyrus Gyrification ... gyrus parahippocampalis Transverse temporal gyrus Lingual gyrus lat. gyrus lingualis Precentral gyrus, lat. gyrus praecentralis ... Superior frontal gyrus, lat. gyrus frontalis superior Middle frontal gyrus, lat. gyrus frontalis medius Inferior frontal gyrus ... gyrus temporalis superior Middle temporal gyrus, lat. gyrus temporalis medius Inferior temporal gyrus, lat. gyrus temporalis ...
Brodmann area L., Nicolae; G., Lacob; O., Popescu B. (2010-11-25). "Gelastic Seizures in a Patient with Right Gyrus Cinguli ... It is a narrow band located in the anterior cingulate gyrus adjacent to the supracallosal gyrus in the depth of the callosal ... Cytoarchitecturally it is bounded by the ventral anterior cingulate area 24 and the supracallosal gyrus (Brodmann-1909). The ... "Pain and emotion interactions in subregions of the cingulate gyrus". Nature Reviews Neuroscience. 6 (7): 533-544. doi:10.1038/ ...
... gyrus cinguli MeSH A08.186.211.577.405 - hippocampus MeSH A08.186.211.577.405.200 - dentate gyrus MeSH A08.186.211.577.405.200. ... parahippocampal gyrus MeSH A08.186.211.577.710.225 - entorhinal cortex MeSH A08.186.211.577.750 - septum of brain MeSH A08.186. ... parahippocampal gyrus MeSH A08.186.211.730.885.213.863.648.225 - entorhinal cortex MeSH A08.186.211.730.885.362 - corpus ...
The cingulum is a major association tract. The cingulum forms the white matter core of the cingulate gyrus and links from this ... fibers connect different lobes of a hemisphere to each other whereas short association fibers connect different gyri within a ...
... ciliary arteries ciliary body ciliary ganglion ciliary muscle ciliary nerves ciliospinal reflex cilium cingulate gyrus cingulum ... terms of location anatomical terms of motion anatomy Anatomy of the human heart anconeus angiography angiology angular gyrus ... triangle demyelination dendrite dendritic spine dens dental alveolus dental caries dental formula dental pulp dentate gyrus ... muscle inferior pubic ramus inferior rectus muscle inferior sagittal sinus inferior salivatory nucleus inferior temporal gyrus ...
... cingulate gyrus, cingulum, anterior hypothalamus, and head of the caudate nucleus. While some recent literature has suggested ...
It consists of the cingulate gyrus, parahippocampal gyrus, amygdala and the hippocampal formation. Studies in patients who were ... The objective of this procedure is the severing of the supracallosal fibres of the cingulum bundle, which pass through the ... This was derived from the hypothesis of James Papez who thought that the cingulum was a major component of an anatomic circuit ... anterior cingulate gyrus. Cingulotomy was introduced in the 1940s as an alternative to standard pre-frontal leucotomy/lobotomy ...
... was also associated with reduced resting-state FC between the cingulo-opercular network and the right superior frontal gyrus, ... PSI was found to be associated with increased resting-state FC between several nodes of the cingulo-opercular network, a neural ...
In neuroanatomy, the cingulum is a nerve tract - a collection of axons - projecting from the cingulate gyrus to the entorhinal ... The cingulum was one of the earliest identified brain structures. The cingulum is described from various brain images as a C ... Wikimedia Commons has media related to Cingulum (brain). Cingulate Gyrus: Introduction and Surface Morphology (All articles ... The cingulum takes memory information and integrates this to other parts of the brain. Damage to the cingulum also ...
The axons of these parts of the cingulate cortex, linked through the large cingulum (longitudinal bundle located at the base of ... the cingulate cortex), return to the parahippocampal gyrus. This circuit referred to as the Papez circuit (1937) was said by ...
The frontal and parietal lobes are separated from the cingulate gyrus by the cingulate sulcus. It terminates as the marginal ... Cingulate sulcus (labeled as sulcus cinguli) and brain lobes. Medial surface of cerebral hemisphere.Medial view.Deep dissection ... It sends a ramus to separate the paracentral lobule from the frontal gyri, the paracentral sulcus. Position of cingulate sulcus ...
The rostral cingulate gyrus (Brodmanns's area 32) projects to the rostral superior temporal gyrus, midorbitofrontal cortex and ... Cingulum means "belt" in Latin. The name was likely chosen because this cortex, in great part, surrounds the corpus callosum. ... 3D view of the cingulate gyrus (green) and paracingulate gyrus (yellow) in an average human brain Hadland, K. A.; Rushworth M.F ... The metabolic rate of glucose was lower in the left anterior cingulate gyrus and in the right posterior cingulate gyrus. In ...
Specifically, it targets the bilateral orbital part of the frontal gyri, superior occipital gyri, left insula, fusiform, right ... The cingulo-opercular (CO) network fundamentally functions to maintain tonic alertness which is the effortful process of making ... Lesions in the Broca's area in the IFG, the lower part of the precentral gyrus, and the opercular and insular regions are ... Regions like the occipital and lingual gyri are stable for visual feature binding in the visual system network. The parietal ...
During interference tasks, likelihood of activation was reported in the left superior frontal gyrus, right precentral gyrus, ... and decreased FA in inferior longitudinal and cingulum fibers. Glutamate, an excitatory neurotransmitter has been implicated in ... while decreased grey matter was reported in the right temporal gyrus and left insula extending to the inferior frontal gyrus. ... An ALE meta analysis found increased grey matter in the left postcentral gyrus, middle frontal region, putamen, thalamus, left ...
There are major white matter pathway connections with the superior parietal lobule such as the Cingulum, SLF I, superior ... Lateral view of a human brain, main gyri labeled. Cerebrum. Lateral view. Deep dissection. Cerebrum. Lateral view. Deep ... around the end of which it is joined to the occipital lobe by a curved gyrus, the arcus parietooccipitalis. Below, it is ... but is usually connected with the postcentral gyrus above the end of the sulcus. The superior parietal lobule contains ...
The FPN has fewer similarities with the salience network (which has also been equated with the cingulo-opercular network or ... The FPN is primarily composed of the rostral lateral and dorsolateral prefrontal cortex (especially the middle frontal gyrus) ... Additional regions include the middle cingulate gyrus and potentially the dorsal precuneus, posterior inferior temporal lobe, ...
It surrounds a gyrus (pl. gyri), creating the characteristic folded appearance of the brain in humans and other mammals. The ... Sulcus cinguli (ci) Hippocampal fissure (h) Sulcus intraparitalis (ip) Lateral fissure (or Sylvian fissure) (la) Sulcus ... A sulcus is a shallower groove that surrounds a gyrus. A fissure is a large furrow that divides the brain into lobes and also ... Sulci, the grooves, and gyri, the folds or ridges, make up the folded surface of the cerebral cortex. Larger or deeper sulci ...
... thalamus and cingulum, and how their connection is the basis for human emotion. MacLean proposed that the limbic system had ... it can be found mainly in the cingulate gyrus, insula and the subcallosal areas of the brain. The true isocortex is a six ...
Cingulate cortex Cingulum R Leech; R Braga; DJ Sharp (2012). "Echoes of the brain within the posterior cingulate cortex". The ... Haznedar, MM; Buchsbaum, MS; Hazlett, EA; Shihabuddin, L; New, A; Siever, LJ (Dec 1, 2004). "Cingulate gyrus volume and ... They also found that greater damage to the cingulum bundle, that connects the PCC to the anterior DMN, was correlated with ... Furthermore, white matter abnormalities in the cingulum bundle, a structure that connects the PCC to other limbic structures, ...
... and cingulum bundle lesions on tests of spatial memory: Evidence of a double dissociation between frontal and cingulum bundle ... Saab BJ, Georgiou J, Nath A, Lee FJ, Wang M, Michalon A, Liu F, Mansuy IM, Roder JC (2009). "NCS-1 in the dentate gyrus ... The CA3 is innervated by two afferent paths known as the perforant path (PPCA3) and the dentate gyrus (DG)-mediated mossy ... Lee, I.; Kesner, R. P. (2004). "Encoding versus retrieval of spatial memory: Double dissociation between the dentate gyrus and ...
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CCG, cingulum cingulate gyrus; CST, corticospinal tract; FA, fractional anisotropy; ILF, inferior longitudinal fasciculus. ... left and right cingulum cingulate gyrus, left and right corticospinal tracts (CST), and left and right inferior longitudinal ...
Gyrus Cinguli / surgery* * Humans * Male * Memory * Middle Aged * Neurosurgical Procedures / methods* * Obsessive-Compulsive ...
Gyrus Cinguli A8.186.211.577.330 A8.186.211.464.330. Habenula A8.186.211.577.200.360 A8.186.211.464.200.360. A8.186.211.730. ... Dentate Gyrus A8.186.211.577.405.200 A8.186.211.464.405.200. A8.186.211.730.885.287.500.345.200. Dextromethorphan D3.132. ... Parahippocampal Gyrus A8.186.211.577.710 A8.186.211.464.710. A8.186.211.730.885.213.863.648 A8.186.211.730.885.287.500.863.648 ...
Gyrus Cinguli Medicine & Life Sciences 49% * Temporal Lobe Medicine & Life Sciences 44% ... Our findings indicated that (1) CT increased in the left anterior cingulate cortex (ACC) and right middle temporal gyrus (MTG) ... Our findings indicated that (1) CT increased in the left anterior cingulate cortex (ACC) and right middle temporal gyrus (MTG) ... Our findings indicated that (1) CT increased in the left anterior cingulate cortex (ACC) and right middle temporal gyrus (MTG) ...
Gyrus Cinguli Medicine & Life Sciences 92% * Haplorhini Medicine & Life Sciences 82% * Task Performance and Analysis Medicine ...
Gyrus Cinguli Medicine & Life Sciences 40% * Myelin Sheath Medicine & Life Sciences 40% ...
Gyrus Cinguli 13% 45 Scopus citations * Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer ...
Gyrus Cinguli Medicine & Life Sciences 22% View full fingerprint Cite this. * APA ...
Animals, Attention, Choice Behavior, Decision Making, Gyrus Cinguli, Humans, Learning, Neurons, Prefrontal Cortex, Reward ...
Masuda, T., Amann, L., Monaco, G., Sankowski, R., Staszewski, O., Krueger, M., Del Gaudio, F., He, L., Paterson, N., Nent, E., Fernández-Klett, F., Yamasaki, A., Frosch, M., Fliegauf, M., Bosch, L. F. P., Ulupinar, H., Hagemeyer, N., Schreiner, D., Dorrier, C., Tsuda, M., & 10 othersGrothe, C., Joutel, A., Daneman, R., Betsholtz, C., Lendahl, U., Knobeloch, K. P., Lämmermann, T., Priller, J., Kierdorf, K. & Prinz, M., Apr 28 2022, In: Nature. 604, 7907, p. 740-748 9 p.. Research output: Contribution to journal › Article › peer-review ...
To the sensorimotor network, we found bilaterally the precentral and postcentral gyri, supperior motor area, middle cingulum ... lingual gyrus, cerebellum, calcarine sulcus, fusiform, temporal inferior cortex and cuneus. Notice that, from the functional ... areas of hyperconnection from the DMN to the auditory RSN were bilaterally found in Heschls gyri, rolandic operculum, temporal ...
Animals, Attention, Choice Behavior, Decision Making, Gyrus Cinguli, Humans, Learning, Neurons, Prefrontal Cortex, Reward ...
Gyrus Cinguli, Habituation, Psychophysiologic, Happiness, Heart Rate, Hostility, Human-computer interaction, Humans, Image ...
Gyrus Cinguli 14% * Brain Concussion 14% * Cerebellar Cortex 13% * Learning 13% * Cerebellum 13% ...
Gyrus Cinguli Medicine & Life Sciences 87% * Psychotic Disorders Medicine & Life Sciences 79% ...
Gyrus Cinguli Medicine & Life Sciences 73% * AMPA Receptors Medicine & Life Sciences 21% ...
Gyrus Cinguli Medicine & Life Sciences 59% * Prefrontal Cortex Medicine & Life Sciences 51% ...
Gyrus Cinguli Medicine & Life Sciences 50% * Hippocampus Medicine & Life Sciences 39% * Motor Cortex Medicine & Life Sciences ... In the parahippocampal gyrus and hippocampus, the distribution of 5-HT uptake sites was camplementary to the distribution of 5- ... In the parahippocampal gyrus and hippocampus, the distribution of 5-HT uptake sites was camplementary to the distribution of 5- ... In the parahippocampal gyrus and hippocampus, the distribution of 5-HT uptake sites was camplementary to the distribution of 5- ...
Gyrus Cinguli 22% 114 Scopus citations * Abscopal effect following proton beam radiotherapy in a patient with inoperable ...
Gyrus Cinguli 17% * Therapeutics 14% * Antipsychotic Agents 10% 24 被引用数 (Scopus) ...
Pfeifer, D. P., Chwialkowski, M., Clarke, G., McColl, R., Ibrahim, Y., Losh, J. & Penshock, R., Dec 1 1993, Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 1 ed. Publ by IEEE, p. 186-187 2 p. (Proceedings of the Annual Conference on Engineering in Medicine and Biology; vol. 15, no. pt 1).. Research output: Chapter in Book/Report/Conference proceeding › Conference contribution ...
Gyrus Cinguli 25% * Drug 19% * Brain 18% * Central Amygdaloid Nucleus 16% 5 Scopus citations ...
... also showed that there were severe perfusion defects at superior temporal region and less perfusion defects at gyrus cingulum ...
Gyrus Cinguli Medicine & Life Sciences 26% * Cerebral Cortex Medicine & Life Sciences 23% ...
Gyri, Posterior Cingulate. Gyrus Cinguli Anterior. Gyrus Cinguli Anteriors. Gyrus, Anterior Cingulate. Gyrus, Cingular. Gyrus, ... Gyrus Cinguli Anteriors, Gyrus Cortex, Anterior Cingulate Cortices, Anterior Cingulate Gyrus Cinguli Anterior Gyrus Cinguli ... Anterior Cingulate Gyrus Anterior Cingulates Anterior, Gyrus Cinguli Anteriors, Gyrus Cinguli Cingulate Cortex, Anterior ... Anterior Cingulate Gyrus. Anterior Cingulates. Anterior, Gyrus Cinguli. Anteriors, Gyrus Cinguli. Area, Cingulate. Areas, ...
perior frontal gyrus (anterior part). Gyrus cinguli. Lobulus paracentralis Sulcus cinguli Gyrus cinguli ... The lingual gyrus is sometimes subdivided by a furrow (sulcus sagittalis gyri lingualis) midway between the collateral sulcus ... It is composed of three bands of different texture, the middle temporal gyrus, the inferior temporal gyrus, and the pararhinal ... The sulcus temporalis inferior, which forms the line of demarcation between the gyrus temporalis inferior and the gyrus Sulcus ...
  • Our findings indicated that (1) CT increased in the left anterior cingulate cortex (ACC) and right middle temporal gyrus (MTG) after L2 learning, (2) CT in the right MTG increased in individuals who were better able to discriminate between native language and L2 words, and (3) CT in the left ACC was correlated with functional connectivity between the ACC and MTG. (elsevier.com)
  • It is composed of three bands of different texture, the middle temporal gyrus, the inferior temporal gyrus, and the pararhinal gyrus, which fringes the area piriformis on the tentorial surface. (co.ma)
  • In the parahippocampal gyrus and hippocampus, the distribution of 5-HT uptake sites was camplementary to the distribution of 5-HTia and 5-HT2 receptors. (elsevier.com)
  • In addition, Remembered items elicited greater activity in the right hippocampus and parahippocampal gyrus than items accorded Know judgments, replicating previous findings. (nau.edu)
  • Network hubs including anterior and middle cingulate cortex, superior frontal areas, medial occipital areas, the parahippocampal gyrus, post- and precentral gyri, and the precuneus had the strongest contribution to this phenomenon. (tau.ac.il)
  • A comparison of the Layer-wise Relevance Propagation heatmaps of the older cohort vs the younger cohort showed that there was greater relevance in the older brains compared to younger brains ( P = .5) in the T1 sub-ensemble in the lateral ventricles, corpus callosum, amygdala, cerebral white matter (especially in the paracingulate gyrus), opercular cortex, and (secondary) somatosensory cortex. (medscape.com)
  • The great extent of the middle and inferior temporal gyri constitutes one of the outstanding features distinctive of the Pararhinal gyrus human brain. (co.ma)
  • The FLAIR sub-ensemble had the most information around the lateral ventricles, anterior temporal gyri, the pre- and postcentral gyri, and white matter areas. (medscape.com)
  • The findings indicated that several FAB scores (including composite and item scores) provided valid measures of right hemispheric lateral frontal lobe dysfunction, specifically of focal lesions near the anterior insula, in the right middle frontal gyrus, and in the right inferior frontal gyrus. (medscape.com)
  • The base models using the T1 sub-ensemble had the most information in the lateral ventricle, corpus callosum, pre- and postcentral gyri in the motor and sensorimotor cortex, operculum, and all gray matter border areas. (medscape.com)
  • For the FLAIR sub-ensemble, the increase was in the cerebellum (specifically, left and right crus I-II), caudate, inferior frontal gyrus, pars triangularis, insular cortex, and inferior parietal lobule. (medscape.com)
  • has shown that the fibres passing to and from these two gyri are the last to become medullated, later even than the important Sulcus sagittalis parietal and frontal areas. (co.ma)
  • Results: In the trauma-versus-neutral word contrast, patients showed increased activation compared to HC in the BNST, medial prefrontal cortex (mPFC), posterior cingulate gyrus (PCG), caudate heads, and midbrain, and decreased activation in dorsolateral prefrontal cortex (DLPFC). (nyu.edu)
  • We showed that children display a stronger EEB than adults and that this correlates with reduced activation in right supramarginal gyrus (rSMG) as well as reduced coupling between rSMG and left dorsolateral prefrontal cortex (lDLPFC) in children compared with adults. (virginia.edu)
  • furthermore, FA values were reduced in the bilateral cingulate, right insular cortex, precuneus and superior frontal gyrus, and increased in the bilateral fusiform gyri, right superior temporal gyrus, right middle frontal lobe of schizophrenia patients compared with healthy controls. (jneuropsychiatry.org)
  • The cingulum is used for the connections of the two subdivisions described above and with the parahippocampal gyrus. (fandom.com)
  • EIS also elicited a more negative ERP deflection (N1000-1500) than did ECS between 1,000 and 1,500 ms. The generator of N1000-1500 was localized near the parahippocampal gyrus, which might be related to unpleasant emotions induced by a lack of reward feedback. (northampton.ac.uk)
  • During the provocation of fatigue, CFS patients reported feelings of both fatigue and anxiety and, compared to controls, they showed increased activation in the occipito-parietal cortex, posterior cingulate gyrus and parahippocampal gyrus, and decreased activation in dorsolateral and dorsomedial prefrontal cortices. (bath.ac.uk)
  • Using voxel-wise analysis, fractional anisotropy was found to be significantly increased in the attention-deficit hyperactivity disorder group in the right superior frontal gyrus and posterior thalamic radiation, and left dorsal posterior cingulate gyrus, lingual gyrus, and parahippocampal gyrus. (elsevier.com)
  • It includes the cortex of the cingulate gyrus, which lies immediately above the corpus callosum, and the continuation of this in the cingulate sulcus. (fandom.com)
  • Recurrent nerve Sulcus cinguli Calloso-marginal fis- N. alveolaris in. (co.ma)
  • The superolateral surface shows the central sulcus that separates the pre-central and post-central gyri. (exonpublications.com)
  • The orbital part of the inferior surface shows H-shaped orbital sulcus, olfactory sulcus, and olfactory gyrus. (exonpublications.com)
  • PS were then contrasted with HC, showing strong reductions in anterior hippocampal connectivity to anterior neocortical regions, including medial frontal and anterior cingulate cortices, as well as superior temporal gyrus, precuneus, thalamus and cerebellum. (elsevier.com)
  • Results: Compared with the healthy controls, the first-episode MDD patients showed higher fALFF in the left mid cingulum, right precuneus, and left superior frontal gyrus (SFG). (neuroptometry.com)
  • Using fMRI, we found that holding a non-food versus food stimulus in working memory was associated with increased activity in occipital gyrus, fusiform, inferior and superior frontal gyrus. (vumc.nl)
  • It receives inputs from the thalamus and the neocortex , and projects to the entorhinal cortex via the cingulum . (fandom.com)
  • Patients also revealed a reversed activation pattern from controls in response to this contrast in the left anterior cingulate, insula, right inferior frontal gyrus (IFG), and bilateral middle frontal gyrus. (illinois.edu)
  • In the human it separates the cingulate gyrus from the superior frontal gyrus dorsal to the body and rostral to the genu. (washington.edu)
  • Results showed that: Expectation incongruent stimuli (EIS) elicited a more positive ERP deflection (P400-700) than did expectation congruent stimuli (ECS) between 400 and 700 ms. Furthermore, dipole source analysis revealed that the generator of P400-700 was localized near the posterior cingulate gyrus (PCC), which might be involved in the monitoring and controlling of reward expectation conflict (expectation violation). (northampton.ac.uk)
  • This psychological feature could conceivably have a biological relationship to the greater thickness of the anterior cingulate gyrus and higher density of von Economo neurons previously reported in SuperAgers. (northwestern.edu)
  • Association fiber systems thus exposed are the cingulum (22), leading toward the uncus, and the inferior longitudinal fasciculus (22), seen more posteriorly extending between the occipital and temporal areas. (stanford.edu)
  • Inferior temporal gyrus. (stanford.edu)
  • The temporal lobe is divided into superior, middle, and inferior temporal gyri. (exonpublications.com)
  • The superior surface of the superior temporal gyrus is occupied by the primary and secondary speech areas. (exonpublications.com)
  • Compared with HC, SZ showed stronger dALFF in the right inferior temporal gyrus (ITG.R) at baseline. (psychiatryinvestigation.org)
  • 11 ] observed that increased ALFF including the middle temporal, orbito-frontal, inferior occipital and fronto-insular gyrus in patients compared with healthy controls. (psychiatryinvestigation.org)
  • The targets for cingulotomy are the supracallosal fibres of the cingulum bundle (part of the Papez circuit ) as it travels through the anterior cingulate gyrus. (advancedinterventions.org.uk)
  • Broca's motor speech area is present in the dominant hemisphere at the inferior frontal gyrus. (exonpublications.com)
  • After medication, the SZ group exhibited reduced dALFF in the right middle occipital gyrus (MOG.R) and increased dALFF in the left superior frontal gyrus (SFG.L), right middle frontal gyrus (MFG.R), and right inferior parietal lobule (IPL.R). Dynamic ALFF in IPL.R was found to significant negative correlate with the Scale for the Assessment of Negative Symptoms (SANS) scores at baseline. (psychiatryinvestigation.org)
  • 5-HT 1A immunoreactivity (IR) was localized to the proximal axon near the axon hillock of cells in the pyramidal cell layer of the cornu Ammonus and in the granule cell layer of the dentate gyrus. (nyu.edu)
  • The intensity of 5-HT 1A -IR was increased in the CA1 and dentate gyrus following 5,7-DHT lesions. (nyu.edu)
  • Dear DTI friends, i want to illustrate my DTI results using MNI standard glass brain (render, 3-dim), adding my tract as an overlay (Cingulum cingulate gyrus left Mask), and my result file as further overlay (tbss Cingulum cingulate gyrus left). (nitrc.org)
  • However, when they tested the patients again on the 12th week (this means 6 weeks after treatment has completed), only the psychotherapeutically treated patients retained the increased blood flow in the right posterior cingulum. (nikhelbig.at)
  • Clinical symptoms of the medial surface of the left hemisphere were analyzed in connection with an astrocytoma destroying the cingulitis of the left gyrus and the contiguous part of the medial surface of the forehead and wall lobe. (elitmed.hu)