Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Trachea: The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.Tracheal NeoplasmsGuinea: A republic in western Africa, south of SENEGAL and MALI, east of GUINEA-BISSAU. Its capital is Conakry.Papua New Guinea: A country consisting of the eastern half of the island of New Guinea and adjacent islands, including New Britain, New Ireland, the Admiralty Islands, and New Hanover in the Bismarck Archipelago; Bougainville and Buka in the northern Solomon Islands; the D'Entrecasteaux and Trobriand Islands; Woodlark (Murua) Island; and the Louisiade Archipelago. It became independent on September 16, 1975. Formerly, the southern part was the Australian Territory of Papua, and the northern part was the UN Trust Territory of New Guinea, administered by Australia. They were administratively merged in 1949 and named Papua and New Guinea, and renamed Papua New Guinea in 1971.Muscle, Smooth: Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)New Guinea: Originally an island of the Malay Archipelago, the second largest island in the world. It divided, West New Guinea becoming part of Indonesia and East New Guinea becoming Papua New Guinea.Tracheal DiseasesMuscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Tracheal StenosisLung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Ileum: The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.Bronchi: The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.Ascorbic Acid Deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)Swine Diseases: Diseases of domestic swine and of the wild boar of the genus Sus.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Equatorial Guinea: A republic in central Africa, bordering the Bay of Biafra, CAMEROON is to the north and GABON to the south. Its capital is Malabo.Larynx: A tubular organ of VOICE production. It is located in the anterior neck, superior to the TRACHEA and inferior to the tongue and HYOID BONE.SRS-A: A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)Respiratory System: The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.Bronchoconstriction: Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Electric Stimulation: Use of electric potential or currents to elicit biological responses.Sus scrofa: A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.Substance P: An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.Atropine: An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Intubation, Intratracheal: A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Neurokinin A: A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.Hypersensitivity, Delayed: An increased reactivity to specific antigens mediated not by antibodies but by cells.Mucus: The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.Aerosols: Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.Vagus Nerve: The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).Airway Resistance: Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.Capsaicin: An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.Airway Obstruction: Any hindrance to the passage of air into and out of the lungs.Myenteric Plexus: One of two ganglionated neural networks which together form the ENTERIC NERVOUS SYSTEM. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility. (From FASEB J 1989;3:127-38)Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.Bronchoscopy: Endoscopic examination, therapy or surgery of the bronchi.Tracheotomy: Surgical incision of the trachea.Perilymph: The fluid separating the membranous labyrinth from the osseous labyrinth of the ear. It is entirely separate from the ENDOLYMPH which is contained in the membranous labyrinth. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1396, 642)Tachykinins: A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.Cochlea: The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.Roseolovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, whose viruses have been isolated from lymphocytes. HERPESVIRUS 6, HUMAN is the type species.Heart: The hollow, muscular organ that maintains the circulation of the blood.Parasympatholytics: Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Papillary Muscles: Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.Piperidines: A family of hexahydropyridines.Bronchial Spasm: Spasmodic contraction of the smooth muscle of the bronchi.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Animal Feed: Foodstuff used especially for domestic and laboratory animals, or livestock.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.Exocrine Glands: Glands of external secretion that release its secretions to the body's cavities, organs, or surface, through a duct.Muscarinic Antagonists: Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.Histamine Antagonists: Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.Histamine H1 Antagonists: Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.Antigens: Substances that are recognized by the immune system and induce an immune reaction.Parasympathetic Nervous System: The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.Immune Sera: Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.Kinetics: The rate dynamics in chemical or physical systems.Adrenergic beta-Agonists: Drugs that selectively bind to and activate beta-adrenergic receptors.Aminophylline: A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Leukotriene D4: One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.Rodent Diseases: Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).TracheitisMethacholine Compounds: A group of compounds that are derivatives of beta-methylacetylcholine (methacholine).Vasoactive Intestinal Peptide: A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).Hemorrhagic Fever, American: Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).Mucous Membrane: An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.Receptors, Muscarinic: One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3....) that are characterized by their cellular actions, pharmacology, and molecular biology.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Weaning: Permanent deprivation of breast milk and commencement of nourishment with other food. (From Stedman, 25th ed)Diphenylacetic AcidsElectrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Nodose Ganglion: The inferior (caudal) ganglion of the vagus (10th cranial) nerve. The unipolar nodose ganglion cells are sensory cells with central projections to the medulla and peripheral processes traveling in various branches of the vagus nerve.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Antitussive Agents: Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
"Beta-adrenergic activities of octopamine and synephrine stereoisomers on guinea-pig isolated atria and trachea." J. Pharm. ... guinea pig: 400 mg/kg. "Lethal doses", given s.c., were found to be: mouse: 400 mg/kg; rat: 500 mg/kg; guinea pig: 500 mg/kg. ... on strips of guinea pig aorta and on the field-stimulated guinea pig ileum showed that synephrine had an agonist potency of − ... In studies on guinea pig atria and trachea, Jordan and co-workers also found that synephrine had negligible activity on β1 and ...
The pharmacologic profile of this medication included the fact its potency in isolated guinea pig trachea is greater than that ...
Research on rats and guinea pigs revealed that synthetic calciseptine and FS2 as well, have the same effect as their natural ... Furthermore, it can also relax the trachea rings in the lungs. These effects can be explained by the relaxing activity of ... De Weille J. R., Schweitz H., Maes P., Tartar A., Lazdunski M (1991). "Calciseptine, a peptide isolated from black mamba venom ... Calciseptine (CaS) is a natural neurotoxin isolated from the black mamba Dendroaspis p. polylepis venom. This toxin consists of ...
... in isolated guinea pig papillary muscle". Japanese journal of pharmacology. 50 (1): 75-8. doi:10.1254/jjp.50.75. PMID 2724702. ... Higenamine is a beta-adrenergic agonist which has effects on the function of trachea and heart muscles. During a study of acute ... Liu, W; Sato, Y; Hosoda, Y; Hirasawa, K; Hanai, H (2000). "Effects of higenamine on regulation of ion transport in guinea pig ... "Endothelium-dependent higenamine-induced aortic relaxation in isolated rat aorta". Planta Medica. 63 (2): 130-2. doi:10.1055/s- ...
THOV can be transmitted between ticks when they feed simultaneously on apparently uninfected guinea pigs, in the absence of a ... First isolated from ticks gathered from cattle in the Thogoto Forest region of Kenya, near Nairobi, in 1960, it is now known to ... Lower levels of virus are found in the trachea, digestive tract and female sex organs, but not in the male sex organs or the ... dynamics of Thogoto virus infection in female ticks during feeding on guinea pigs", Experimental Parasitology, 104: 20-25, doi: ...
... guinea pigs, rats, and occasionally pigs, and marmosets with infection passing through both air and direct contact routes. The ... SeV induces lesions within the respiratory tract, usually associated with bacterial inflammation of the trachea and lung ( ... and the non-breeding adults isolated for two months. Faísca, P; Desmecht D (Mar 8, 2006). "Sendai virus, the mouse ...
Pigs in the Philippines have been reported to be infected with Reston virus, so other interim or amplifying hosts may exist. ... Zaire ebolavirus isolate H.sapiens-wt/GIN/2014/Makona-Kissidougou-C15, complete genome, GenBank Taylor, D.; Leach, R.; Bruenn, ... The toll was particularly grave in three countries: Guinea, Liberia, and Sierra Leone. A few cases were also reported in ... TIM1 is expressed in tissues known to be seriously impacted by EBOV lysis (trachea, cornea, and conjunctiva). A monoclonal ...
As in humans, the Guinea pig's thymus naturally atrophies as the animal reaches adulthood, but the athymic hairless guinea pig ... In the neck, it lies on the front and sides of the trachea, behind the sternohyoidei and sternothyreoidei. The thymus enlarges ... By further proliferation of the cells lining the flask, buds of cells are formed, which become surrounded and isolated by the ...
... guinea pigs (20,687), squirrels (4,446) and voles (2,457). Humans get lung cancer from tobacco smoking. Syrian hamsters are a ... The emphysema component of COPD may be induced in hamsters by injecting pancreatic elastase into their tracheas. Pulmonary ... "Characterization of virulence of Leptospira isolates in a hamster model". Vaccine. 26 (31): 3892-3896. doi:10.1016/j.vaccine. ... guinea pig, hamster, and other rodents (1st ed.). Amsterdam: Elsevier Academic Press. pp. 747-753. ISBN 0123809207. Valentine, ...
... with the dingo and New Guinea singing dog "breeds" having developed at a time when human populations were more isolated from ... but their predation only affects the pig population together with the presence of water buffaloes (which hinder the pigs' ... They kill their prey by biting the throat, which damages the trachea and the major blood vessels of the neck.[63] The size of ... In New Guinea, the earliest dog remains date to 2,500-2,300 YBP from Caution Bay near Port Moresby, but no ancient New Guinea ...
"Beta-adrenergic activities of octopamine and synephrine stereoisomers on guinea-pig isolated atria and trachea." J. Pharm. ... guinea pig: 400 mg/kg. "Lethal doses", given s.c., were found to be: mouse: 400 mg/kg; rat: 500 mg/kg; guinea pig: 500 mg/kg.[ ... In studies on guinea pig atria and trachea, Jordan and co-workers also found that synephrine had negligible activity on β1 and ... on strips of guinea pig aorta and on the field-stimulated guinea pig ileum showed that synephrine had an agonist potency of − ...
Responses of guinea-pig isolated, perfused trachea (IPT) to luminally-applied hypertonic and isotonic osmolyte solutions.. ... Urea caused contraction or relaxation in different tracheas. NaCl was primarily relaxant. These findings suggest that EpDRF ...
In the same way, the histamine (30 μM)-induced tonic contraction of non-sensitized guinea-pig trachea was recorded. The isobole ... In the same way, the histamine (30 μM)-induced tonic contraction of non-sensitized guinea-pig trachea was recorded. The isobole ... daidzein and hesperetin on their antispasmodic effects in the isolated sensitized and non-sensitized guinea-pig tracheas, to ... induced contraction in the sensitized guinea-pig trachea. In contrast, the isobole showed synergism between daidzein and ...
Isolated guinea pig trachea studies.. Tracheal spiral strips were prepared and contractions were performed as described by Malo ... Guinea pig trachea studies.. The effect of ABT-761 on the contraction of guinea pig trachea induced by several agonists was ... AA-induced bronchospasm in the anesthetized guinea pig.. Adult male albino Hartley-strain guinea pigs were anesthetized with an ... Antigen-induced bronchospasm in the anesthetized guinea pig.. Bronchoconstriction in sensitized guinea pigs was induced and ...
Ko, W. C., Lei, C. B., Lin, Y. L., & Chen, C. F. (2000). Relaxant effects of petasins in isolated guinea pig trachea and their ... Ko, W. C. ; Lei, C. B. ; Lin, Y. L. ; Chen, C. F. / Relaxant effects of petasins in isolated guinea pig trachea and their ... Relaxant effects of petasins in isolated guinea pig trachea and their structure-activity relationships. / Ko, W. C.; Lei, C. B ... Ko, WC, Lei, CB, Lin, YL & Chen, CF 2000, Relaxant effects of petasins in isolated guinea pig trachea and their structure- ...
... vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea ... vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea. ... of Artemisia vulgaris was studied against concentration-response curves for contractions of the guinea pig ileum and trachea to ... extract showed histamine H1 antagonism in the ileum and trachea. Further analysis of AV-CHCl3 isolated two major components, ...
In vivo airway reactivity to MCh was measured by placing conscious, guinea pigs in a two-chamber whole body plethysmograph for ... on guinea pig reactivity to methacholine (MCh) in vivo and in vitro. ... Airway reactivity in vitro was measured using the isolated, perfused trachea preparation to permit MCh addition separately to ... Lipopolysaccharide-induced airway hyporeactivity to methacholine in guinea pigs in vivo is absent in the isolated, perfused ...
C-fiber stimulation or direct smooth muscle contraction were studied using isolated tracheal rings from male guinea pigs under ... Direct measurement of acetylcholine release in guinea pig trachea. Am J Physiol. 1992;263:L142-7. PubMed ... Non-adrenergic, non-cholinergic contractions in the electrically field stimulated guinea-pig trachea. Br J Pharmacol. 1990;101: ... Dexmedetomidines inhibitory effects on acetylcholine release from cholinergic nerves in guinea pig trachea: a mechanism that ...
"Beta-adrenergic activities of octopamine and synephrine stereoisomers on guinea-pig isolated atria and trachea." J. Pharm. ... guinea pig: 400 mg/kg. "Lethal doses", given s.c., were found to be: mouse: 400 mg/kg; rat: 500 mg/kg; guinea pig: 500 mg/kg. ... on strips of guinea pig aorta and on the field-stimulated guinea pig ileum showed that synephrine had an agonist potency of − ... In studies on guinea pig atria and trachea, Jordan and co-workers also found that synephrine had negligible activity on β1 and ...
Holme G, Brunet G, Hasson P Girard Y, Rokach J (1980). The activity of synthetic leukotriene C4 on guinea pig trachea and ileum ... Goldenberg HM, Subers EM (1982). The reactivity of rat isolated gastrointestinal tissues to leukotrienes. Eur J Pharmacol 78: ... 8-dioxyanthraquinone-induced production of prostaglandins in rat isolated colon. Prostaglandins 26: 547CrossRefGoogle Scholar ... and we have now investigated the effect of laxatives on arachidonic acid metabolism by human isolated colonic mucosa and muscle ...
The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol 1994 ...
Publications] T.Hisada et al.: Properties of mebrane currents in isolated smooth muscle cells from guinea pig trachea. ... Publications] Nakaya,H.et al.: Betaーadrenoceptor mediated depolarization of the resting membrane in guinea pig papillary ... adrenoceptors of the inward calcium and the delayed rectifier potassium cruuent in single ventricular cells of the guinea pig ... Publications] Tohse,N.et al.: Inhibitory effect mediated by alpha 1ーadrenoceptors on transient outward current in isolated rat ...
The pharmacologic profile of this medication included the fact its potency in isolated guinea pig trachea is greater than that ...
The onset and duration of action in vitro of selected compounds were assessed on isolated superfused guinea pig trachea. ...
1984) Effects of five different organic calcium antagonists on guinea-pig isolated trachea. Br J Pharmacol 82:727-733. ... Isolation of the Trachea and Organ Bath Preparation.. On the day of the experiments, the guinea pigs were euthanized by an ... 1981) Sources of calcium for contraction of guinea-pig isolated tracheal smooth muscle. Clin Exp Pharmacol Physiol 8:175-182. ... 1984) Antagonism of Ca2+ and other actions of verapamil in guinea-pig isolated trachealis. Br J Pharmacol 81:499-507. ...
Flufenamic and tolfenamic acids and lemakalim relax guinea-pig isolated trachea by different ... ... on the relaxations induced by flufenamic and tolfenamic acids and lemakalim were examined in guinea-pig isolated trachea ... The inhibitory and relaxant effects of flufenamic and tolfenamic acids on guinea-pig isolated bronchus were compared with those ... Fenamates inhibit contraction of guinea-pig isolated bronchus in vitro independent of prostanoid ... ...
Pharmacologic characterization of wool dust extract in isolated guinea pig trachea. Authors. ...
... were investigated using isolated guinea-pig trachea. Dose response relationships between PDEs and contraction of guinea-pig ...
Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. Planta Med. 2005 May;71(5):406-11. Abstract ↑ ...
MVIIC caused similar concentration-dependent reductions of the electrically induced twitch responses of guinea-pig ileum. The ... Calcium channel subtypes for cholinergic and nonadrenergic noncholinergic neurotransmission in isolated guinea pig trachea. * ... Lack of effect of Z-butylidenephthalide on presynaptic N-type Ca2+ channels in isolated guinea-pig ileum. *Marcelo Chen, Wun- ... Differential effects of omega-conotoxin GVIA and MVIIC on nerve stimulation induced contractions of guinea-pig ileum and rat ...
... vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea. ... vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea. ...
Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. Planta Med 2005;71(5):406-411. ... Vasodilative effect of perillaldehyde on isolated rat aorta. Phytomedicine 2005;12(5):333-337. ...
This action was determined by verifying the relaxant action on the isolated guinea-pig trachea previously contracted with ... Under these conditions, 11(R)-hydroxy-13-oxa-prostanoic acid provoked a moderate decrease of the basal tonus of the guinea-pig ... The isometric tension of the guinea-pig tracheal preparations was continuously registered. An initial tension of 8 g was ... in which R1 has the same meaning as above and which can be used either isolated or not in the following step:. (d) Treatment of ...
Guinea Pig Trachea Assay: NK2 in vitro functional assay (Test D) The ability of a Compound of the invention to antagonize the ... "Pharmacological examination of receptors mediating contractile responses to tachykinins in airways isolated from human, guinea ... Male guinea pigs are killed by a sharp blow to the back of the head followed by exsanguination. The trachea are removed, ... in a pulmonary tissue may be demonstrated using a functional assay in guinea pig trachea which is carried out under conditions ...
Acetamide-45 inhibits histamine-and methacholine-induced contraction of isolated guinea pig trachea. Pages(152-156) Yun-Bin LU ... Effect of mifepristone on uterine receptivity in guinea pigs. Pages(177-182) Cheng-Quan LIU, Zhong-Xing WANG, Yao YUAN ... Characterization of transient outward K+ current and ultra-rapid delayed rectifier K+ current in isolated human atrial myocytes ...
  • In vivo airway reactivity to MCh was measured by placing conscious, guinea pigs in a two-chamber whole body plethysmograph for measuring specific airway resistance (SRaw) and exposing them to increasing concentrations of MCh aerosol. (cdc.gov)
  • The barrier integrity of hairless guinea pig skin after treatment with an alpha hydroxy acid was assessed through in vivo topical application of an oil-in-water emulsion containing 5 or 10% glycolic acid at pH 3.0. (biomedsearch.com)
  • Además se evaluó diarrea in vivo inducida con aceite de ricino en ratas y la actividad de harina de carbón vegetal en ratones. (bvsalud.org)
  • La diarrea inducida in vivo por el aceite de ricino en ratas y la actividad de la harina de carbón vegetal en ratones apoyaron aún más la actividad espasmolítica. (bvsalud.org)
  • Ragazzi, E., Froldi, G. and Fassina, G. (1988) Resveratrol activity on guinea pig isolated trachea from normal and albumin-sensitized animals. (scirp.org)
  • Proença J, Paiva MQ, Guimarães S (1988) The guinea-pig trachea O-methylating system is more effective in modulating β 2 -than β 1 -adrenoceptor-mediated responses to isoprenaline. (springer.com)
  • More importantly, the compound potently inhibited antigen-induced bronchospasm in guinea pigs when given either prophylactically or therapeutically. (aspetjournals.org)
  • Synephrine, although already known as a synthetic organic compound, was first isolated as a natural product from the leaves of various Citrus trees, and its presence noted in different Citrus juices, by Stewart and co-workers in the early 1960s. (wikipedia.org)
  • To elucidate the underlying mechanism(s) of the antioxidative effect of honokiol, peripheral neutrophils isolated from rats were activated with phorbol-12-myristate-13-acetate (PMA) or N -formyl-methionyl-leucyl-phenylalanine (fMLP) in the presence or absence of honokiol. (chemweb.com)
  • According to Feng Mingguo's report, CsB could slow down the beat of isolated culture of myocardial cell of rats. (duiyaoonline.com)
  • On the basis of this assumption, we selected the known octapeptide SP antagonist D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp-Phe-NH2 (1) as a lead and synthesized its fragment tripeptides which were evaluated for their activity to block 3H-SP binding on guinea pig lung membranes. (nih.gov)
  • In the present study, we attempted to compare four petasins, isolated from Petasites formosanus Kitamura, and to look for structure-activity relationships, which may be helpful for synthesizing more active compounds for the treatment of asthma. (elsevier.com)
  • Characterization of transient outward K+ current and ultra-rapid delayed rectifier K+ current in isolated human atrial myocytes from patients with congestive heart failure. (chinaphar.com)
  • Experiments were conducted to determine the effect of fumaric acid supplementation and buffering capacity of the diet on ileal and fecal digestibilities of CP, GE, and amino acids in early-weaned pigs. (biomedsearch.com)
  • Boughton-Smith et al 1983), and we have now investigated the effect of laxatives on arachidonic acid metabolism by human isolated colonic mucosa and muscle. (springer.com)