A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.
Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of growth hormone receptors regulates amino acid transport through cell membranes, RNA translation to protein, DNA transcription, and protein and amino acid catabolism in many cell types. Many of these effects are mediated indirectly through stimulation of the release of somatomedins.
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
A peptide of 44 amino acids in most species that stimulates the release and synthesis of GROWTH HORMONE. GHRF (or GRF) is synthesized by neurons in the ARCUATE NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, GHRF stimulates GH release by the SOMATOTROPHS in the PITUITARY GLAND.
Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.
A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
A form of dwarfism caused by complete or partial GROWTH HORMONE deficiency, resulting from either the lack of GROWTH HORMONE-RELEASING FACTOR from the HYPOTHALAMUS or from the mutations in the growth hormone gene (GH1) in the PITUITARY GLAND. It is also known as Type I pituitary dwarfism. Human hypophysial dwarf is caused by a deficiency of HUMAN GROWTH HORMONE during development.
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
Surgical removal or destruction of the hypophysis, or pituitary gland. (Dorland, 28th ed)
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.
Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
Hormones synthesized from amino acids. They are distinguished from INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS in that their actions are systemic.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively.
Transmembrane proteins that recognize and bind GHRELIN, a potent stimulator of GROWTH HORMONE secretion and food intake in mammals. Ghrelin receptors are found in the pituitary and HYPOTHALAMUS. They belong to the family of G-PROTEIN-COUPLED RECEPTORS.
The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.
A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.
A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. Placental lactogen is also an insulin antagonist.
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.
A genetic or pathological condition that is characterized by short stature and undersize. Abnormal skeletal growth usually results in an adult who is significantly below the average height.
Therapeutic use of hormones to alleviate the effects of hormone deficiency.
Hormones produced by the placenta include CHORIONIC GONADOTROPIN, and PLACENTAL LACTOGEN as well as steroids (ESTROGENS; PROGESTERONE), and neuropeptide hormones similar to those found in the hypothalamus (HYPOTHALAMIC HORMONES).
Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Structurally, they include polypeptide, protein, and glycoprotein molecules.
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Cell surface receptors that bind the hypothalamic hormones regulating pituitary cell differentiation, proliferation, and hormone synthesis and release, including the pituitary-releasing and release-inhibiting hormones. The pituitary hormone-regulating hormones are also released by cells other than hypothalamic neurons, and their receptors also occur on non-pituitary cells, especially brain neurons, where their role is less well understood. Receptors for dopamine, which is a prolactin release-inhibiting hormone as well as a common neurotransmitter, are not included here.
The distance from the sole to the crown of the head with body standing on a flat surface and fully extended.
A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Gradual increase in the number, the size, and the complexity of cells of an individual. Growth generally results in increase in ORGAN WEIGHT; BODY WEIGHT; and BODY HEIGHT.
Compounds, either natural or synthetic, which block development of the growing insect.
A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Labile proteins on or in prolactin-sensitive cells that bind prolactin initiating the cells' physiological response to that hormone. Mammary casein synthesis is one of the responses. The receptors are also found in placenta, liver, testes, kidneys, ovaries, and other organs and bind and respond to certain other hormones and their analogs and antagonists. This receptor is related to the growth hormone receptor.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide.
Proteins prepared by recombinant DNA technology.
Insulin-like polypeptides made by the liver and some fibroblasts and released into the blood when stimulated by SOMATOTROPIN. They cause sulfate incorporation into collagen, RNA, and DNA synthesis, which are prerequisites to cell division and growth of the organism.
One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
A POU domain factor that regulates expression of GROWTH HORMONE; PROLACTIN; and THYROTROPIN-BETA in the ANTERIOR PITUITARY GLAND.
Establishment of the age of an individual by examination of their skeletal structure.
Elements of limited time intervals, contributing to particular results or situations.
Peptide hormones produced by NEURONS of various regions in the HYPOTHALAMUS. They are released into the pituitary portal circulation to stimulate or inhibit PITUITARY GLAND functions. VASOPRESSIN and OXYTOCIN, though produced in the hypothalamus, are not included here for they are transported down the AXONS to the POSTERIOR LOBE OF PITUITARY before being released into the portal circulation.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Peptides, natural or synthetic, that stimulate the release of PITUITARY HORMONES. They were first isolated from the extracts of the HYPOTHALAMUS; MEDIAN EMINENCE; PITUITARY STALK; and NEUROHYPOPHYSIS. In addition, some hypophysiotropic hormones control pituitary cell differentiation, cell proliferation, and hormone synthesis. Some can act on more than one pituitary hormone.
Glucose in blood.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.
A glycoprotein that causes regression of MULLERIAN DUCTS. It is produced by SERTOLI CELLS of the TESTES. In the absence of this hormone, the Mullerian ducts develop into structures of the female reproductive tract. In males, defects of this hormone result in persistent Mullerian duct, a form of MALE PSEUDOHERMAPHRODITISM.
A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.
Hormones produced by the GONADS, including both steroid and peptide hormones. The major steroid hormones include ESTRADIOL and PROGESTERONE from the OVARY, and TESTOSTERONE from the TESTIS. The major peptide hormones include ACTIVINS and INHIBINS.
An autosomal recessive disorder characterized by short stature, defective GROWTH HORMONE RECEPTOR, and failure to generate INSULIN-LIKE GROWTH FACTOR I by GROWTH HORMONE. Laron syndrome is not a form of primary pituitary dwarfism (GROWTH HORMONE DEFICIENCY DWARFISM) but the result of mutation of the human GHR gene on chromosome 5.
High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRB gene (also known as NR1A2, THRB1, or ERBA2 gene) as several isoforms produced by alternative splicing. Mutations in the THRB gene cause THYROID HORMONE RESISTANCE SYNDROME.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Examinations that evaluate functions of the pituitary gland.
The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.
Cell surface receptors that bind specific neuropeptides with high affinity and trigger intracellular changes influencing the behavior of cells. Many neuropeptides are also hormones outside of the nervous system.
A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
HORMONES secreted by the gastrointestinal mucosa that affect the timing or the quality of secretion of digestive enzymes, and regulate the motor activity of the digestive system organs.
Established cell cultures that have the potential to propagate indefinitely.
The biologically active fragment of human growth hormone-releasing factor, consisting of GHRH(1-29)-amide. This N-terminal sequence is identical in several mammalian species, such as human, pig, and cattle. It is used to diagnose or treat patients with GROWTH HORMONE deficiency.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.
The relative amounts of various components in the body, such as percentage of body fat.
The surgical removal of one or both ovaries.
The measurement of an organ in volume, mass, or heaviness.
The major protein constituents of milk are CASEINS and whey proteins such as LACTALBUMIN and LACTOGLOBULINS. IMMUNOGLOBULINS occur in high concentrations in COLOSTRUM and in relatively lower concentrations in milk. (Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed, p554)
Form of radioimmunoassay in which excess specific labeled antibody is added directly to the test antigen being measured.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The rate dynamics in chemical or physical systems.
Anterior pituitary cells which produce GROWTH HORMONE.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. (Int J Gynaecol Obstet 1992;39(1):3-9)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRA gene (also known as NR1A1, THRA1, ERBA or ERBA1 gene) as several isoforms produced by alternative splicing.
Cell surface receptors that bind thyrotropin releasing hormone (TRH) with high affinity and trigger intracellular changes which influence the behavior of cells. Activated TRH receptors in the anterior pituitary stimulate the release of thyrotropin (thyroid stimulating hormone, TSH); TRH receptors on neurons mediate neurotransmission by TRH.
A benign pituitary-region neoplasm that originates from Rathke's pouch. The two major histologic and clinical subtypes are adamantinous (or classical) craniopharyngioma and papillary craniopharyngioma. The adamantinous form presents in children and adolescents as an expanding cystic lesion in the pituitary region. The cystic cavity is filled with a black viscous substance and histologically the tumor is composed of adamantinomatous epithelium and areas of calcification and necrosis. Papillary craniopharyngiomas occur in adults, and histologically feature a squamous epithelium with papillations. (From Joynt, Clinical Neurology, 1998, Ch14, p50)
Hormones secreted by insects. They influence their growth and development. Also synthetic substances that act like insect hormones.
Ductless glands that secrete HORMONES directly into the BLOOD CIRCULATION. These hormones influence the METABOLISM and other functions of cells in the body.
Disorders involving either the ADENOHYPOPHYSIS or the NEUROHYPOPHYSIS. These diseases usually manifest as hypersecretion or hyposecretion of PITUITARY HORMONES. Neoplastic pituitary masses can also cause compression of the OPTIC CHIASM and other adjacent structures.
Hormones produced by invertebrates, usually insects, mollusks, annelids, and helminths.
A benign epithelial tumor with a glandular organization.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
An anti-inflammatory 9-fluoro-glucocorticoid.
Hormones released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). They include a number of peptides which are formed in the NEURONS in the HYPOTHALAMUS, bound to NEUROPHYSINS, and stored in the nerve terminals in the posterior pituitary. Upon stimulation, these peptides are released into the hypophysial portal vessel blood.
Neoplastic, inflammatory, infectious, and other diseases of the hypothalamus. Clinical manifestations include appetite disorders; AUTONOMIC NERVOUS SYSTEM DISEASES; SLEEP DISORDERS; behavioral symptoms related to dysfunction of the LIMBIC SYSTEM; and neuroendocrine disorders.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR) that stimulate gonadal functions in both males and females. They include FOLLICLE STIMULATING HORMONE that stimulates germ cell maturation (OOGENESIS; SPERMATOGENESIS), and LUTEINIZING HORMONE that stimulates the production of sex steroids (ESTROGENS; PROGESTERONE; ANDROGENS).
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
Peptides with the ability to stimulate pigmented cells MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. By stimulating the synthesis and distribution of MELANIN in these pigmented cells, they increase coloration of skin and other tissue. MSHs, derived from pro-opiomelanocortin (POMC), are produced by MELANOTROPHS in the INTERMEDIATE LOBE OF PITUITARY; CORTICOTROPHS in the ANTERIOR LOBE OF PITUITARY, and the hypothalamic neurons in the ARCUATE NUCLEUS OF HYPOTHALAMUS.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Hormones produced in the testis.
A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
The beta subunit of follicle stimulating hormone. It is a 15-kDa glycopolypeptide. Full biological activity of FSH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the FSHB gene causes delayed puberty, or infertility.
The consumption of edible substances.
A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A parathyroid hormone receptor subtype that recognizes both PARATHYROID HORMONE and PARATHYROID HORMONE-RELATED PROTEIN. It is a G-protein-coupled receptor that is expressed at high levels in BONE and in KIDNEY.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A synthetic hormone with anabolic and androgenic properties.
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
Achievement of full sexual capacity in animals and in humans.
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Methods and procedures for the diagnosis of diseases or dysfunction of the endocrine glands or demonstration of their physiological processes.
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Receptors with a 6-kDa protein on the surfaces of cells that secrete LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE, usually in the adenohypophysis. LUTEINIZING HORMONE-RELEASING HORMONE binds to these receptors, is endocytosed with the receptor and, in the cell, triggers the release of LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE by the cell. These receptors are also found in rat gonads. INHIBINS prevent the binding of GnRH to its receptors.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
Transport proteins that carry specific substances in the blood or across cell membranes.
Cell surface proteins that bind PARATHYROID HORMONE with high affinity and trigger intracellular changes which influence the behavior of cells. Parathyroid hormone receptors on BONE; KIDNEY; and gastrointestinal cells mediate the hormone's role in calcium and phosphate homeostasis.
The surgical removal of one or both testicles.
A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.
A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.
An anadromous species of SALMON ranging from the Arctic and Pacific Oceans to Monterey Bay, California and inhabiting ocean and coastal streams. It is familiarly known as the coho or silver salmon. It is relatively small but its light-colored flesh is of good flavor.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The system of glands that release their secretions (hormones) directly into the circulatory system. In addition to the ENDOCRINE GLANDS, included are the CHROMAFFIN SYSTEM and the NEUROSECRETORY SYSTEMS.
Disturbances of MILK secretion in either SEX, not necessarily related to PREGNANCY.
A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.
Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 is the only naturally occurring stable iodine isotope.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)
A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)
A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Surgical removal or artificial destruction of gonads.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The discharge of an OVUM from a rupturing follicle in the OVARY.
The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A metabolite of THYROXINE, formed by the peripheral enzymatic monodeiodination of T4 at the 5 position of the inner ring of the iodothyronine nucleus.
MAMMARY GLANDS in the non-human MAMMALS.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Abstaining from all food.
Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.
Peptides composed of between two and twelve amino acids.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
The chemical reactions involved in the production and utilization of various forms of energy in cells.
A stable synthetic analog of methionine enkephalin (ENKEPHALIN, METHIONINE). Actions are similar to those of methionine enkephalin. Its effects can be reversed by narcotic antagonists such as naloxone.
A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels.
Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter.
Increase in BODY WEIGHT over existing weight.
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
An autosomal dominant disorder caused by deletion of the proximal long arm of the paternal chromosome 15 (15q11-q13) or by inheritance of both of the pair of chromosomes 15 from the mother (UNIPARENTAL DISOMY) which are imprinted (GENETIC IMPRINTING) and hence silenced. Clinical manifestations include MENTAL RETARDATION; MUSCULAR HYPOTONIA; HYPERPHAGIA; OBESITY; short stature; HYPOGONADISM; STRABISMUS; and HYPERSOMNOLENCE. (Menkes, Textbook of Child Neurology, 5th ed, p229)

Vasopressin stimulation of acetate incorporation into lipids in a dimethylbenz(a)anthracene-induced rat mammary tumor cell line. (1/4516)

In a preliminary report we described the effects of rat prolactin on the incorporation of [14C]acetate into lipids by a cell line from a dimethylbenz(a)anthracene-induced rat mammary tumor. The characteristics of the response to prolactin were very similar to those described for the normal rat mammary gland; namely, insulin was required for full expression of the response, maximal activity was not seen until 36 hr after the addition of the hormones, and growth hormone was able to elicit the same response. However, we were unable to detect binding of 125I-labeled prolactin to these cells, and furthermore, other more purified prolactin preparations were inactive. Upon further investigation we discovered that the activity resided in a low-molecular-weight fraction of the rat prolactin B-1 preparation and was probably either vasopressin or oxytocin or both. These data suggest the possibility that vasopressin may play a role in rodent mammary tumorigenesis.  (+info)

Long-term effects of growth hormone (GH) on body fluid distribution in GH deficient adults: a four months double blind placebo controlled trial. (2/4516)

OBJECTIVE: Short-term growth hormone (GH) treatment normalises body fluid distribution in adult GH deficient patients, but the impact of long-term treatment on body fluid homeostasis has hitherto not been thoroughly examined in placebo controlled trials. To investigate if the water retaining effect of GH persists for a longer time we examined the impact of 4 months GH treatment on extracellular volume (ECV) and plasma volume (PV) in GH deficient adults. DESIGN: Twenty-four (18 male, 6 female) adult GH deficient patients aged 25-64 years were included and received either GH (n=11) or placebo (n=13) in a double blind parallel design. METHODS: Before and at the end of each 4 month period ECV and PV were assessed directly using 82Br- and 125I-albumin respectively, and blood samples were obtained. RESULTS: During GH treatment ECV increased significantly (before: 20.48+/-0.99 l, 4 months: 23.77+/-1.38 l (P<0.01)), but remained unchanged during placebo administration (before: 16.92+/-1.01 l, 4 months: 17.60+/-1.24 l (P=0.37)). The difference between the groups was significant (P<0.05). GH treatment also increased PV (before: 3.39+/-0.27 l. 4 months: 3.71+/-0.261 (P=0.01)), although an insignificant increase in the placebo treated patients (before: 2.81+/-0.18 l, 4 months: 2.89+/-0.20 l (P=0.37)) resulted in an insignificant treatment effect (P=0.07). Serum insulin-like growth factor-I increased significantly during GH treatment and was not affected by placebo treatment. Plasma renin (mIU/l) increased during GH administration (before: 14.73+/-2.16, 4 months: 26.00+/-6.22 (P=0.03)) and remained unchanged following placebo (before: 20.77+/-5.13, 4 months: 20.69+/-6.67 (P=0.99)) leaving no significant treatment effect (P=0.08). CONCLUSION: The long-term impact of GH treatment on body fluid distribution in adult GH deficient patients involves expansion of ECV and probably also PV. These data substantiate the role of GH as a regulator of fluid homeostasis in adult GH deficiency.  (+info)

Growth hormone-releasing peptide-2 infusion synchronizes growth hormone, thyrotrophin and prolactin release in prolonged critical illness. (3/4516)

OBJECTIVE: During prolonged critical illness, nocturnal pulsatile secretion of GH, TSH and prolactin (PRL) is uniformly reduced but remains responsive to the continuous infusion of GH secretagogues and TRH. Whether such (pertinent) secretagogues would synchronize pituitary secretion of GH, TSH and/or PRL is not known. DESIGN AND METHODS: We explored temporal coupling among GH, TSH and PRL release by calculating cross-correlation among GH, TSH and PRL serum concentration profiles in 86 time series obtained from prolonged critically ill patients by nocturnal blood sampling every 20 min for 9 h during 21-h infusions of either placebo (n=22), GHRH (1 microg/kg/h; n=10), GH-releasing peptide-2 (GHRP-2; 1 microg/kg/h; n=28), TRH (1 microg/kg/h; n=8) or combinations of these agonists (n=8). RESULTS: The normal synchrony among GH, TSH and PRL was absent during placebo delivery. Infusion of GHRP-2, but not GHRH or TRH, markedly synchronized serum profiles of GH, TSH and PRL (all P< or =0.007). After addition of GHRH and TRH to the infusion of GHRP-2, only the synchrony between GH and PRL was maintained (P=0.003 for GHRH + GHRP-2 and P=0.006 for TRH + GHRH + GHRP-2), and was more marked than with GHRP-2 infusion alone (P=0.0006 by ANOVA). CONCLUSIONS: The nocturnal GH, TSH and PRL secretory patterns during prolonged critical illness are herewith further characterized to include loss of synchrony among GH, TSH and PRL release. The synchronizing effect of an exogenous GHRP-2 drive, but not of GHRH or TRH, suggests that the presumed endogenous GHRP-like ligand may participate in the orchestration of coordinated anterior pituitary hormone release.  (+info)

Neurosurgery restores late GH rise after glucose-induced suppression in cured acromegalics. (4/4516)

OBJECTIVE AND DESIGN: A decrease of GH levels below 2 microg/l after an oral glucose tolerance test (OGTT) is still currently accepted as the gold standard for assessing cure in surgically treated acromegaly. Whether glucose-induced suppression of GH is accompanied by a restoration of normal GH late rebound has not yet been evaluated in this disease. In order to assess the restoration of normal GH regulation after removal of a pituitary adenoma, we have evaluated GH changes after an OGTT in a series of selected acromegalic patients (transsphenoidal surgery and lack of pituitary failure). METHODS: Twenty-nine patients (13 male, 16 female, age range 27-70 years) entered the study. Their neuroradiological imaging before neurosurgery showed microadenoma in 7, intrasellar macroadenoma in 8 and macroadenoma with extrasellar extension in 14. Plasma GH levels were assayed up to 300 min after glucose administration (75 g p.o.) and IGF-I on basal samples. RESULTS: Basal GH levels were below 5 microg/l in 20 patients and below 2 microg/l in 5 of these. Normal age-adjusted IGF-I levels were observed in 12 patients. GH values were suppressed below 2 microg/l during an OGTT in 13 patients, and below 1 microg/l in 7 of these. In 9 patients out of these 13, a marked rise in GH levels occurred after nadir. Baseline and nadir GH values of these 9 patients were not different from the corresponding values of the other 4 patients without OGTT-induced late GH peaks. CONCLUSIONS: GH rebound after GH nadir occurs in acromegalic patients considered as cured on the basis of OGTT-induced GH suppression and/or IGF-I normalization. The restoration of this physiological response could be regarded as a marker of recovered/preserved integrity of the hypothalamic-pituitary axis. Even though the reason for this GH rebound has not yet been elucidated (GHRH discharge?/end of somatostatin inhibition?), the lack of late GH peak in the patients regarded as cured by the usual criteria could be due to injury to the pituitary stalk caused by the adenoma or by surgical manipulation.  (+info)

Long-term results of GH therapy in GH-deficient children treated before 1 year of age. (5/4516)

OBJECTIVES: To evaluate the long-term effects of GH therapy in early diagnosed GH-deficient patients treated before 1 year of age. STUDY DESIGN: We studied all 59 patients (33 males) recorded by Association France-Hypophyse and treated with GH (0.50+/-0.15 IU/kg (S.D.) per week) before 1 year of age. Clinical presentation and growth parameters under GH treatment were analyzed. RESULTS: Neonatal manifestations of hypopituitarism were frequent: hypoglycemia (n=50), jaundice (n=25) and micropenis (n=17/33). Although birth length was moderately reduced (-0.9+/-1.4), growth retardation at diagnosis (5.8+/-3.8 months) was severe (-3.5+/-1.9 standard deviation scores (SDS)). Fifty patients (85%) had thyrotropin and/or corticotropin deficiency. After a mean duration of GH therapy of 8.0+/-3.6 years, change in height SDS was +3.11+/-2.06 S.D., exceeding 4 SDS in 19 patients. Only 9 patients (15%) did not reach a height of -2 S.D. for chronological age and 20 patients (34%) exceeded their target height. Pretreatment height SDS was independently associated with total catch-up growth. CONCLUSION: Conventional doses of GH allow normalization of height in patients with early GH deficiency and treatment.  (+info)

Changes in body composition and leptin levels during growth hormone (GH) treatment in short children with various GH secretory capacities. (6/4516)

OBJECTIVE: The aim of this study was to follow changes in body composition, estimated by dual-energy X-ray absorptiometry (DXA), in relation to changes in leptin during the first year of GH therapy in order to test the hypothesis that leptin is a metabolic signal involved in the regulation of GH secretion in children. DESIGN AND METHODS: In total, 33 prepubertal children were investigated. Their mean (S.D.) chronological age at the start of GH treatment was 11.5 (1.6) years, and their mean height was -2.33 (0.38) S.D. scores (SDS). GH was administered subcutaneously at a daily dose of 0.1 (n=26) or 0.2 (n=7) IU/kg body weight. Ten children were in the Swedish National Registry for children with GH deficiency, and twenty-three children were involved in trials of GH treatment for idiopathic short stature. Spontaneous 24-h GH secretion was studied in 32 of the children. In the 24-h GH profiles, the maximum level of GH was determined and the secretion rate estimated by deconvolution analysis (GHt). Serum leptin levels were measured at the start of GH treatment and after 10 and 30 days and 3, 6 and 12 months of treatment. Body composition measurements, by DXA, were performed at baseline and 12 months after the onset of GH treatment. RESULTS: After 12 months of GH treatment, mean height increased from -2.33 to -1.73 SDS and total body fat decreased significantly by 3.0 (3.3)%. Serum leptin levels were decreased significantly at all time points studied compared with baseline. There was a significant correlation between the change in total body fat and the change in serum leptin levels during the 12 months of GH treatment, whereas the leptin concentration per unit fat mass did not change. In a multiple stepwise linear regression analysis with 12 month change in leptin levels as the dependent variable, the percentage change in fat over 12 months, the baseline fat mass (%) of body mass and GHt accounted for 24.0%, 11.5% and 12.2% of the variability respectively. CONCLUSIONS: There are significant correlations between changes in leptin and fat and endogenous GH secretion in short children with various GH secretory capacities. Leptin may be the messenger by which the adipose tissue affects hypothalamic regulation of GH secretion.  (+info)

Why is the retention of gonadotrophin secretion common in children with panhypopituitarism due to septo-optic dysplasia? (7/4516)

Septo-optic dysplasia (De Morsier syndrome) is a developmental anomaly of mid-line brain structures and includes optic nerve hypoplasia, absence of the septum pellucidum and hypothalamo-pituitary abnormalities. We describe seven patients (four female, three male) who had at least two out of the three features necessary for the diagnosis of septo-optic dysplasia. Four patients had hypopituitarism and yet normal gonadotrophin secretion: one of these also had anti-diuretic hormone insufficiency; three had isolated GH deficiency and yet had premature puberty, with the onset of puberty at least a year earlier than would have been expected for their bone age. In any progressive and evolving anterior pituitary lesion it is extremely unusual to lose corticotrophin-releasing hormone/ACTH and TRH/TSH secretion and yet to retain gonadotrophin secretion. GnRH neurons develop in the nasal mucosa and migrate to the hypothalamus in early fetal life. We hypothesise that the arrival of GnRH neurons in the hypothalamus after the development of a midline hypothalamic defect may explain these phenomena. Progress in spontaneous/premature puberty in children with De Morsier syndrome may have important implications for management. The combination of GH deficiency and premature puberty may allow an apparently normal growth rate but with an inappropriately advanced bone age resulting in impaired final stature. GnRH analogues may be a therapeutic option. In conclusion, some patients with De Morsier syndrome appear to retain the ability to secrete gonadotrophins in the face of loss of other hypothalamic releasing factors. The migration of GnRH neurons after the development of the midline defect may be an explanation.  (+info)

Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1alpha. (8/4516)

Salmon insulin-like growth factor-I (sIGF-I) expression is, as in mammals, induced by growth hormone (GH). To elucidate the mechanism by which GH stimulates the transcription of the IGF-I gene, we transiently transfected Hep3B cells expressing the rat GH receptor with a sIGF-I promoter-luciferase reporter construct. Activation of the construct by GH added to the medium of the transfected cells was observed when two specific transcription factors, STAT5 and HNF-1alpha, were simultaneously overexpressed in these cells. This finding demonstrates for the first time a GH-dependent activation of an IGF-I promoter construct in an immortalized laboratory cell line.  (+info)

Growth hormone (GH) is a peptide hormone produced by the anterior pituitary gland in the brain. It plays a crucial role in regulating growth and development in humans and other animals. GH stimulates the liver to produce insulin-like growth factor 1 (IGF-1), which promotes the growth of bones, muscles, and other tissues. In children, GH is essential for normal growth and development. It stimulates the growth plates in bones to lengthen, leading to increased height. In adults, GH is involved in maintaining muscle mass, bone density, and overall body composition. GH deficiency can lead to a variety of health problems, including short stature in children, decreased muscle mass and strength, increased body fat, and decreased bone density. GH replacement therapy is sometimes used to treat GH deficiency, particularly in children with growth disorders. In addition to its role in growth and development, GH has been studied for its potential therapeutic effects in a variety of conditions, including obesity, diabetes, and aging. However, the use of GH as a performance-enhancing drug is banned by most sports organizations due to its potential to increase muscle mass and strength.

Human Growth Hormone (HGH) is a peptide hormone produced by the anterior pituitary gland in the brain. It plays a crucial role in regulating growth and development in children and adolescents, as well as maintaining various bodily functions in adults. In children, HGH stimulates the growth of bones, muscles, and other tissues, and helps to regulate metabolism. It also plays a role in the development of the brain and the immune system. In adults, HGH is involved in maintaining muscle mass, bone density, and overall body composition. It also plays a role in regulating metabolism and energy levels, and may help to improve cognitive function and mood. HGH deficiency can occur due to various factors, including genetic disorders, pituitary gland tumors, and aging. Treatment for HGH deficiency typically involves hormone replacement therapy, which involves administering synthetic HGH to replace the naturally occurring hormone in the body.

Receptors, Somatotropin are proteins found on the surface of cells that bind to and respond to growth hormone (somatotropin), a hormone produced by the anterior pituitary gland. These receptors play a crucial role in regulating growth and development in animals, including humans. Activation of somatotropin receptors can stimulate cell growth, division, and differentiation, as well as regulate metabolism and body composition. Dysregulation of somatotropin receptors has been implicated in various diseases, including acromegaly and gigantism in humans.

Hormones are chemical messengers produced by glands in the endocrine system that regulate various bodily functions. They are transported through the bloodstream to target cells or organs, where they bind to specific receptors and trigger a response. Hormones play a crucial role in regulating growth and development, metabolism, reproduction, and other essential processes in the body. Examples of hormones include insulin, thyroid hormones, estrogen, testosterone, and cortisol. Imbalances in hormone levels can lead to a range of medical conditions, including diabetes, thyroid disorders, infertility, and mood disorders.

Growth Hormone-Releasing Hormone (GHRH) is a peptide hormone that is produced by the hypothalamus, a region of the brain that regulates various bodily functions, including growth and metabolism. GHRH stimulates the anterior pituitary gland to produce and release growth hormone (GH), which is responsible for promoting growth and development in children and maintaining muscle mass and bone density in adults. GHRH is a 44-amino acid peptide that is synthesized and secreted by the arcuate nucleus of the hypothalamus. It acts on the pituitary gland by binding to specific receptors on the surface of the somatotroph cells, which are responsible for producing GH. Once bound to the receptors, GHRH triggers a signaling cascade that leads to the synthesis and release of GH from the pituitary gland. GHRH is also involved in regulating other hormones, such as thyroid-stimulating hormone (TSH) and adrenocorticotropic hormone (ACTH), which are also produced by the anterior pituitary gland. In addition, GHRH has been shown to have effects on appetite, metabolism, and body composition. Abnormalities in GHRH production or signaling can lead to various medical conditions, including growth hormone deficiency, acromegaly, and gigantism. Treatment for these conditions may involve the use of GH replacement therapy or medications that target the GHRH signaling pathway.

Thyroid hormones are hormones produced by the thyroid gland, a small gland located in the neck. There are two main types of thyroid hormones: thyroxine (T4) and triiodothyronine (T3). These hormones play a crucial role in regulating metabolism, growth, and development in the body. Thyroxine (T4) is the primary thyroid hormone produced by the thyroid gland. It is converted into triiodothyronine (T3) in the body, which is the more active thyroid hormone. T3 and T4 are responsible for regulating the body's metabolism, which is the process by which the body converts food into energy. They also play a role in regulating the body's growth and development, as well as the function of the heart and nervous system. Thyroid hormones are regulated by the hypothalamus and the pituitary gland, which are located in the brain. The hypothalamus produces a hormone called thyrotropin-releasing hormone (TRH), which stimulates the pituitary gland to produce thyroid-stimulating hormone (TSH). TSH then stimulates the thyroid gland to produce T4 and T3. Abnormal levels of thyroid hormones can lead to a variety of health problems, including hyperthyroidism (too much thyroid hormone), hypothyroidism (too little thyroid hormone), and thyroid nodules or cancer. Treatment for thyroid disorders typically involves medication to regulate the levels of thyroid hormones in the body.

Follicle Stimulating Hormone (FSH) is a hormone produced by the anterior pituitary gland in the brain. It plays a crucial role in the development and maturation of ovarian follicles in females and sperm production in males. In females, FSH stimulates the growth and maturation of ovarian follicles, which contain eggs. As the follicles mature, they release estrogen, which causes the lining of the uterus to thicken in preparation for a potential pregnancy. If fertilization does not occur, the levels of estrogen and FSH decrease, leading to the shedding of the uterine lining and the start of a new menstrual cycle. In males, FSH stimulates the production of sperm in the testes. It also plays a role in the development of the prostate gland and the regulation of testosterone levels. FSH levels can be measured in the blood to diagnose and monitor various medical conditions, such as infertility, polycystic ovary syndrome (PCOS), and hypogonadism.

Growth disorders refer to conditions that affect the growth and development of an individual. These disorders can affect the rate of growth, the pattern of growth, or the final height of an individual. Growth disorders can be caused by a variety of factors, including genetic, hormonal, nutritional, or environmental factors. Some common examples of growth disorders include: 1. Dwarfism: A condition characterized by short stature due to genetic or hormonal factors. 2. Turner Syndrome: A genetic disorder that affects females and is characterized by short stature, infertility, and other physical and developmental abnormalities. 3. Marfan Syndrome: A genetic disorder that affects connective tissue and can cause tall stature, skeletal abnormalities, and cardiovascular problems. 4. Growth Hormone Deficiency: A condition in which the body does not produce enough growth hormone, which can lead to short stature and other physical and developmental abnormalities. 5. Prader-Willi Syndrome: A genetic disorder that affects the brain and body and is characterized by short stature, obesity, and other physical and behavioral abnormalities. Treatment for growth disorders depends on the underlying cause and may include hormone therapy, surgery, or other medical interventions. In some cases, growth hormone therapy can be used to stimulate growth in individuals with growth hormone deficiency.

Insulin-like Growth Factor I (IGF-I) is a protein hormone that plays a crucial role in regulating growth and development in humans and other animals. It is produced by the liver, as well as by other tissues such as the kidneys, muscles, and bones. IGF-I has insulin-like effects on cells, promoting the uptake of glucose and the synthesis of proteins. It also stimulates the growth and differentiation of various cell types, including muscle cells, bone cells, and cartilage cells. In the medical field, IGF-I is often used as a diagnostic tool to measure growth hormone (GH) levels in patients with growth disorders or other conditions that affect GH production. It is also used as a treatment for certain conditions, such as growth hormone deficiency, Turner syndrome, and short stature. However, excessive levels of IGF-I have been linked to an increased risk of certain cancers, such as colon cancer and breast cancer, and it is therefore important to monitor IGF-I levels carefully in patients with these conditions.

Prolactin is a hormone produced by the anterior pituitary gland in the brain. It plays a crucial role in the development and function of the mammary glands in both males and females, but it is particularly important for lactation in females. In females, prolactin stimulates the production of milk in the mammary glands after childbirth. It also plays a role in regulating the menstrual cycle and fertility. In males, prolactin helps to regulate the production of sperm and testosterone. Prolactin levels can be affected by a variety of factors, including stress, sleep, and certain medications. Abnormal levels of prolactin can lead to a condition called hyperprolactinemia, which can cause a range of symptoms including breast tenderness, infertility, and sexual dysfunction.

Luteinizing hormone (LH) is a hormone produced by the anterior pituitary gland in the brain. It plays a crucial role in regulating the reproductive system in both males and females. In females, LH stimulates the ovaries to produce estrogen and progesterone, which are essential for the menstrual cycle and pregnancy. It also triggers ovulation, the release of a mature egg from the ovary. In males, LH stimulates the testes to produce testosterone, which is responsible for the development of male secondary sexual characteristics and the production of sperm. LH levels can be measured in the blood or urine to diagnose and monitor various reproductive disorders, such as infertility, polycystic ovary syndrome (PCOS), and hypogonadism. It is also used in fertility treatments, such as in vitro fertilization (IVF), to stimulate ovulation and increase the chances of conception.

Dwarfism, Pituitary is a medical condition characterized by short stature due to a deficiency of growth hormone (GH) or other hormones produced by the pituitary gland. The pituitary gland is a small endocrine gland located at the base of the brain that plays a crucial role in regulating growth and development in the body. In individuals with dwarfism, pituitary, the pituitary gland fails to produce enough GH, which is necessary for normal growth and development. This can result in a variety of symptoms, including short stature, delayed puberty, and other physical and developmental abnormalities. Dwarfism, pituitary can be caused by a variety of factors, including genetic mutations, tumors, or damage to the pituitary gland. Treatment for dwarfism, pituitary typically involves hormone replacement therapy to replace the missing hormones and promote normal growth and development. In some cases, surgery may be necessary to remove tumors or other abnormalities that are causing the deficiency in hormones.

Gonadotropin-Releasing Hormone (GnRH) is a hormone that is produced by the hypothalamus, a region of the brain that regulates various bodily functions, including reproductive processes. GnRH plays a crucial role in regulating the production of sex hormones by the gonads (ovaries in females and testes in males). In females, GnRH stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary gland, which in turn stimulates the ovaries to produce estrogen and progesterone. These hormones are essential for the development of secondary sexual characteristics, menstrual cycle, and pregnancy. In males, GnRH stimulates the release of FSH and LH from the anterior pituitary gland, which in turn stimulates the testes to produce testosterone. Testosterone is responsible for the development of secondary sexual characteristics, sperm production, and muscle mass. GnRH is also used in medical treatments, such as infertility, menopause, and prostate cancer. It is administered as a medication to stimulate the production of FSH and LH, which can help to induce ovulation in women or stimulate sperm production in men. In menopause, GnRH is used to reduce the production of estrogen and testosterone, which can help to alleviate symptoms such as hot flashes and vaginal dryness. In prostate cancer, GnRH is used to reduce the production of testosterone, which can slow the growth of cancer cells.

Parathyroid hormone (PTH) is a hormone produced by the parathyroid glands, which are four small glands located in the neck, near the thyroid gland. PTH plays a crucial role in regulating the levels of calcium and phosphorus in the body. PTH acts on the bones, kidneys, and intestines to increase the levels of calcium in the blood. It stimulates the release of calcium from the bones into the bloodstream, increases the reabsorption of calcium by the kidneys, and promotes the absorption of calcium from the intestines. PTH also plays a role in regulating the levels of phosphorus in the body. It stimulates the kidneys to excrete phosphorus in the urine, which helps to maintain the proper balance of calcium and phosphorus in the blood. Abnormal levels of PTH can lead to a variety of medical conditions, including hyperparathyroidism (too much PTH), hypoparathyroidism (too little PTH), and parathyroid cancer. Hyperparathyroidism can cause osteoporosis, kidney stones, and other complications, while hypoparathyroidism can lead to muscle cramps, seizures, and other symptoms.

Gonadal steroid hormones are hormones produced by the gonads (testes in males and ovaries in females) that regulate sexual development and reproductive function. These hormones include testosterone, estrogen, and progesterone. Testosterone is the primary male sex hormone and is responsible for the development of male secondary sexual characteristics, such as facial hair and a deep voice. Estrogen is the primary female sex hormone and is responsible for the development of female secondary sexual characteristics, such as breast development and a wider pelvis. Progesterone is a hormone that helps regulate the menstrual cycle and prepare the uterus for pregnancy. Gonadal steroid hormones also play a role in other bodily functions, such as bone health, mood regulation, and immune system function. Imbalances in these hormones can lead to a variety of health problems, including infertility, menstrual disorders, and sexual dysfunction.

Pituitary hormones are a group of hormones produced by the pituitary gland, a small endocrine gland located at the base of the brain. The pituitary gland is often referred to as the "master gland" because it controls the function of many other endocrine glands in the body. There are several types of pituitary hormones, including: 1. Growth hormone (GH): This hormone stimulates growth and cell reproduction in the body. 2. Thyroid-stimulating hormone (TSH): This hormone stimulates the thyroid gland to produce thyroid hormones, which regulate metabolism. 3. Adrenocorticotropic hormone (ACTH): This hormone stimulates the adrenal gland to produce cortisol, a hormone that helps the body respond to stress. 4. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH): These hormones regulate the function of the ovaries and testes, including the production of sex hormones and the development of eggs and sperm. 5. Prolactin: This hormone stimulates milk production in the mammary glands. 6. Antidiuretic hormone (ADH): This hormone regulates the body's water balance by controlling the amount of water that is reabsorbed by the kidneys. 7. Oxytocin: This hormone stimulates uterine contractions during childbirth and milk ejection during breastfeeding. Pituitary hormones play a critical role in regulating many bodily functions, including growth, metabolism, stress response, reproduction, and water balance. Imbalances in pituitary hormone levels can lead to a variety of health problems, including dwarfism, thyroid disorders, adrenal insufficiency, infertility, and diabetes insipidus.

Acromegaly is a rare hormonal disorder that occurs when the pituitary gland produces too much growth hormone (GH). This excess GH causes the body's tissues to grow abnormally, leading to a variety of physical and health problems. The most noticeable physical changes associated with acromegaly are the enlargement of the hands, feet, and facial features, particularly the nose, lips, and jaw. Other symptoms may include joint pain, thickening of the skin, excessive sweating, and sleep apnea. Acromegaly is typically diagnosed through a combination of physical examination, blood tests to measure GH levels, and imaging studies such as MRI or CT scans to visualize the pituitary gland. Treatment options for acromegaly may include surgery to remove the pituitary tumor, radiation therapy, and medications to lower GH levels. Early diagnosis and treatment are important to prevent complications and improve quality of life for individuals with acromegaly.

Peptide hormones are a type of hormone that are composed of chains of amino acids. They are synthesized in the endocrine glands and are released into the bloodstream to regulate various bodily functions. Peptide hormones are involved in a wide range of processes, including growth and development, metabolism, reproduction, and the regulation of the body's response to stress. Examples of peptide hormones include insulin, growth hormone, and thyroid-stimulating hormone. These hormones act on specific receptors in target cells to produce their effects, and they are often regulated by feedback mechanisms to maintain homeostasis in the body.

Adrenocorticotropic Hormone (ACTH) is a hormone produced by the anterior pituitary gland in the brain. It stimulates the adrenal glands to produce and release cortisol, a hormone that helps the body respond to stress and regulates metabolism, immune function, and blood pressure. ACTH is also involved in the regulation of other hormones, such as aldosterone, which helps regulate blood pressure and electrolyte balance, and androgens, which are male sex hormones. In the medical field, ACTH is often used to diagnose and treat disorders related to the adrenal glands, such as Cushing's disease, which is caused by an overproduction of cortisol, and Addison's disease, which is caused by a deficiency of cortisol. ACTH is also used to stimulate the adrenal glands to produce cortisol in cases where the glands are not producing enough of the hormone on their own.

Receptors, Thyroid Hormone are proteins found on the surface of cells in the body that bind to thyroid hormones, such as thyroxine (T4) and triiodothyronine (T3). These hormones are produced by the thyroid gland and play a crucial role in regulating metabolism, growth, and development. When thyroid hormones bind to their receptors, they trigger a cascade of chemical reactions within the cell that ultimately leads to changes in gene expression and cellular function. There are two main types of thyroid hormone receptors: alpha (α) and beta (β). The α receptor is found primarily in the liver, heart, and skeletal muscle, while the β receptor is found in almost all tissues in the body. Thyroid hormone receptors can be activated by both T4 and T3, but T3 is generally more potent than T4. In addition, thyroid hormones can also bind to other receptors, such as the nuclear receptor superfamily, which can modulate their effects on gene expression. Abnormalities in thyroid hormone receptor function can lead to a variety of health problems, including thyroid disorders such as hyperthyroidism and hypothyroidism, as well as other conditions such as cardiovascular disease and osteoporosis.

Receptors, Ghrelin are proteins found on the surface of cells in the body that bind to the hormone ghrelin. Ghrelin is a hormone that is produced by the stomach and plays a role in regulating appetite and metabolism. When ghrelin binds to its receptors, it can stimulate hunger and increase food intake. The receptors for ghrelin are found in a variety of tissues throughout the body, including the brain, the pancreas, and the fat cells.

Triiodothyronine, also known as T3, is a hormone produced by the thyroid gland. It plays a crucial role in regulating metabolism, growth, and development in the body. T3 is synthesized from thyroxine (T4), another thyroid hormone, by removing an iodine atom from each of the three iodine atoms in T4. In the medical field, T3 is often measured as a diagnostic tool to evaluate thyroid function. Abnormal levels of T3 can indicate a variety of thyroid disorders, including hypothyroidism (low thyroid hormone levels) and hyperthyroidism (high thyroid hormone levels). T3 levels may also be monitored in patients with certain conditions, such as heart disease, to assess their overall health and response to treatment.

Ghrelin is a hormone produced by the stomach that plays a role in regulating appetite and metabolism. It is primarily produced by cells in the stomach called ghrelin cells, which are stimulated by the presence of food in the stomach. Ghrelin is released into the bloodstream in response to fasting and low blood sugar levels, and it signals the brain to increase appetite and stimulate the release of growth hormone. In addition to its role in appetite regulation, ghrelin has been shown to play a role in the regulation of energy metabolism, insulin sensitivity, and the body's response to stress.

Placental lactogen, also known as human placental lactogen (HPL), is a hormone produced by the placenta during pregnancy. It is a type of growth hormone that plays a crucial role in the development and growth of the fetus. Placental lactogen is responsible for stimulating the growth of the fetus's liver, which is necessary for the production of insulin-like growth factor 1 (IGF-1). IGF-1 is a hormone that promotes the growth and development of various tissues in the body, including bones, muscles, and organs. Placental lactogen also helps to regulate the mother's metabolism during pregnancy. It stimulates the production of insulin, which helps to regulate the mother's blood sugar levels. Additionally, placental lactogen helps to increase the mother's blood volume, which is necessary to support the growth and development of the fetus. Placental lactogen levels can be measured in the mother's blood or urine during pregnancy to monitor fetal growth and development. Abnormal levels of placental lactogen can be an indication of pregnancy complications, such as preeclampsia or gestational diabetes.

Pituitary neoplasms are tumors that develop in the pituitary gland, a small endocrine gland located at the base of the brain. The pituitary gland is responsible for producing and regulating various hormones in the body, and when a tumor develops, it can disrupt the normal functioning of the gland and lead to a variety of symptoms. There are several types of pituitary neoplasms, including: 1. Pituitary adenomas: These are the most common type of pituitary neoplasm and are usually benign (non-cancerous). They can produce excessive amounts of hormones, leading to symptoms such as headaches, vision problems, and hormonal imbalances. 2. Pituitary carcinomas: These are rare and aggressive forms of pituitary neoplasms that can spread to other parts of the body. 3. Pituitary macroadenomas: These are larger tumors that can cause symptoms such as hormonal imbalances, headaches, and vision problems. 4. Pituitary microadenomas: These are smaller tumors that may not cause any symptoms, but can still be detected through imaging tests. Treatment for pituitary neoplasms may include surgery, radiation therapy, and medication to manage symptoms and hormone levels. The specific treatment approach will depend on the type and size of the tumor, as well as the patient's overall health and symptoms.

Hypopituitarism is a medical condition in which the pituitary gland, a small gland located at the base of the brain, fails to produce one or more of its hormones or does not produce them in sufficient quantities. The pituitary gland is responsible for producing hormones that regulate various bodily functions, including growth, metabolism, reproduction, and stress response. Hypopituitarism can be caused by a variety of factors, including tumors, head injuries, infections, radiation therapy, and certain medications. Symptoms of hypopituitarism can vary depending on which hormones are affected, but may include fatigue, weight loss, decreased appetite, cold intolerance, decreased sexual desire, infertility, and mood changes. Treatment for hypopituitarism typically involves hormone replacement therapy to replace the hormones that are not being produced by the pituitary gland. The specific hormones that need to be replaced will depend on which hormones are affected and the severity of the deficiency. In some cases, surgery or radiation therapy may be necessary to treat the underlying cause of the hypopituitarism.

Dwarfism is a medical condition characterized by short stature, which is defined as an adult height of 4 feet 10 inches (147 centimeters) or less for males and 4 feet 6 inches (137 centimeters) or less for females. Dwarfism can be caused by a variety of genetic and non-genetic factors, including chromosomal abnormalities, hormonal imbalances, and skeletal dysplasias. There are over 200 different types of dwarfism, each with its own specific genetic cause and set of symptoms. Some forms of dwarfism are inherited, while others are caused by random genetic mutations or environmental factors. Individuals with dwarfism may also experience other health problems, such as joint pain, vision and hearing problems, and an increased risk of certain medical conditions, such as diabetes and heart disease. Treatment for dwarfism typically involves addressing any underlying health issues and providing supportive care to help individuals with dwarfism live healthy, fulfilling lives. This may include physical therapy, orthopedic surgery, and hormone replacement therapy.

Placental hormones are hormones that are produced by the placenta, a specialized organ that develops during pregnancy and provides nourishment and protection to the developing fetus. These hormones play important roles in regulating various physiological processes in both the mother and the fetus, including fetal growth and development, maternal metabolism, and the onset of labor. Some of the key placental hormones include human chorionic gonadotropin (hCG), progesterone, estrogen, relaxin, and human placental lactogen (hPL). hCG is produced early in pregnancy and helps to maintain the corpus luteum, which produces progesterone to support the pregnancy. Estrogen and progesterone help to prepare the uterus for pregnancy and maintain the pregnancy, while relaxin helps to soften and widen the cervix in preparation for labor. hPL is involved in regulating maternal metabolism and promoting fetal growth and development. Placental hormones play a critical role in maintaining a healthy pregnancy and ensuring the proper development of the fetus. Abnormal levels of these hormones can lead to complications such as miscarriage, preterm labor, and gestational diabetes.

The anterior pituitary gland is a small endocrine gland located at the base of the brain, and it is responsible for producing and secreting several hormones that play important roles in regulating various bodily functions. The hormones produced by the anterior pituitary gland include: 1. Growth hormone (GH): This hormone stimulates growth and cell reproduction in the body. 2. Thyroid-stimulating hormone (TSH): This hormone stimulates the thyroid gland to produce thyroid hormones, which regulate metabolism. 3. Adrenocorticotropic hormone (ACTH): This hormone stimulates the adrenal gland to produce cortisol, which helps the body respond to stress. 4. Follicle-stimulating hormone (FSH): This hormone stimulates the ovaries or testes to produce sex hormones and eggs or sperm. 5. Luteinizing hormone (LH): This hormone stimulates the ovaries or testes to produce sex hormones and trigger ovulation or sperm production. 6. Prolactin (PRL): This hormone stimulates milk production in the mammary glands. These hormones are essential for maintaining normal bodily functions, and imbalances in their production or secretion can lead to various health problems.

Thyroxine, also known as T4, is a hormone produced by the thyroid gland in the neck. It plays a crucial role in regulating metabolism, growth, and development in the body. In the medical field, thyroxine is often prescribed to treat hypothyroidism, a condition in which the thyroid gland does not produce enough thyroid hormones. In this case, thyroxine is given to replace the missing hormone and help restore normal metabolic function. Thyroxine is also used to treat certain types of thyroid cancer, as well as to prevent the recurrence of thyroid cancer after surgery. In some cases, thyroxine may be used to treat other conditions, such as Turner syndrome, a genetic disorder that affects females. Thyroxine is typically taken orally in the form of a tablet or liquid, and the dosage is adjusted based on the patient's individual needs and response to treatment. It is important to follow the instructions provided by a healthcare provider when taking thyroxine, as taking too much or too little can have serious consequences.

Somatostatin is a hormone that is produced by the pancreas and the hypothalamus in the brain. It is also known as growth hormone-inhibiting hormone (GHIH) or somatotropin release-inhibiting hormone (SRIF). Somatostatin plays a role in regulating the release of other hormones, including growth hormone, thyroid-stimulating hormone, and insulin. It also has a role in controlling the digestive system, as it can inhibit the release of digestive enzymes and slow down the movement of food through the digestive tract. In the medical field, somatostatin is used to treat a variety of conditions, including acromegaly (a condition in which the body produces too much growth hormone), carcinoid syndrome (a condition in which the body produces too much serotonin), and certain types of diarrhea. It is also being studied for its potential use in treating other conditions, such as Alzheimer's disease and cancer.

Hydrocortisone is a synthetic glucocorticoid hormone that is used in the medical field to treat a variety of conditions. It is a potent anti-inflammatory and immunosuppressive agent that can help reduce inflammation, swelling, and redness in the body. Hydrocortisone is also used to treat conditions such as allergies, asthma, eczema, and psoriasis, as well as to reduce the symptoms of adrenal insufficiency, a condition in which the body does not produce enough of the hormone cortisol. It is available in a variety of forms, including oral tablets, topical creams, and injections.

Insulin is a hormone produced by the pancreas that regulates the amount of glucose (sugar) in the bloodstream. It helps the body's cells absorb glucose from the bloodstream and use it for energy or store it for later use. Insulin is essential for maintaining normal blood sugar levels and preventing conditions such as diabetes. In the medical field, insulin is used to treat diabetes and other conditions related to high blood sugar levels. It is typically administered through injections or an insulin pump.

Receptors, Pituitary Hormone-Regulating Hormone (RH-RH) are a type of protein receptor found in the pituitary gland that are activated by the hormone called "Releasing Hormone" (RH). RH-RH receptors are responsible for regulating the production and release of various hormones from the pituitary gland, including growth hormone, thyroid-stimulating hormone, and adrenocorticotropic hormone. These hormones play important roles in regulating various bodily functions, such as growth, metabolism, and stress response. Dysfunction of RH-RH receptors can lead to various medical conditions, including hypopituitarism and acromegaly.

In the medical field, "body height" refers to the vertical distance from the ground to the top of the head when standing upright with the feet together and heels against a flat surface. It is typically measured in centimeters or inches and is an important factor in determining a person's overall health and well-being. Body height can be influenced by genetics, nutrition, and environmental factors, and can vary significantly among individuals. In some cases, a person's body height may be used as a diagnostic indicator for certain medical conditions, such as growth hormone deficiency or Turner syndrome.

Thyrotropin, also known as thyroid-stimulating hormone (TSH), is a hormone produced by the anterior pituitary gland in the brain. It plays a crucial role in regulating the function of the thyroid gland, which is responsible for producing hormones that control metabolism in the body. TSH stimulates the thyroid gland to produce and release thyroid hormones, including thyroxine (T4) and triiodothyronine (T3). These hormones regulate the body's metabolism, affecting how the body uses energy and how quickly it burns calories. In the medical field, TSH is often measured as part of routine blood tests to assess thyroid function. Abnormal levels of TSH can indicate a variety of thyroid disorders, including hypothyroidism (an underactive thyroid) and hyperthyroidism (an overactive thyroid). TSH levels can also be affected by other medical conditions, such as pituitary tumors or certain medications.

In the medical field, RNA, Messenger (mRNA) refers to a type of RNA molecule that carries genetic information from DNA in the nucleus of a cell to the ribosomes, where proteins are synthesized. During the process of transcription, the DNA sequence of a gene is copied into a complementary RNA sequence called messenger RNA (mRNA). This mRNA molecule then leaves the nucleus and travels to the cytoplasm of the cell, where it binds to ribosomes and serves as a template for the synthesis of a specific protein. The sequence of nucleotides in the mRNA molecule determines the sequence of amino acids in the protein that is synthesized. Therefore, changes in the sequence of nucleotides in the mRNA molecule can result in changes in the amino acid sequence of the protein, which can affect the function of the protein and potentially lead to disease. mRNA molecules are often used in medical research and therapy as a way to introduce new genetic information into cells. For example, mRNA vaccines work by introducing a small piece of mRNA that encodes for a specific protein, which triggers an immune response in the body.

Estradiol is a naturally occurring hormone that is produced by the ovaries in females and by the testes in males. It is a type of estrogen, which is a group of hormones that play a key role in the development and regulation of the female reproductive system, as well as in the maintenance of secondary sexual characteristics in both males and females. Estradiol is a potent estrogen and is one of the most biologically active forms of estrogen in the body. It is involved in a wide range of physiological processes, including the regulation of the menstrual cycle, the development of female sexual characteristics, and the maintenance of bone density. Estradiol also plays a role in the regulation of the cardiovascular system, the brain, and the immune system. Estradiol is used in medicine to treat a variety of conditions, including menopause, osteoporosis, and certain types of breast cancer. It is available in a variety of forms, including tablets, patches, and gels, and is typically administered by mouth or applied to the skin. It is important to note that estradiol can have side effects, and its use should be carefully monitored by a healthcare provider.

Testosterone is a hormone that is primarily produced in the testicles in males and in smaller amounts in the ovaries and adrenal glands in females. It is responsible for the development of male sexual characteristics, such as the growth of facial hair, deepening of the voice, and muscle mass. Testosterone also plays a role in bone density, red blood cell production, and the regulation of the body's metabolism. In the medical field, testosterone is often used to treat conditions related to low testosterone levels, such as hypogonadism (a condition in which the body does not produce enough testosterone), delayed puberty, and certain types of breast cancer in men. It can also be used to treat conditions related to low estrogen levels in women, such as osteoporosis and menopause symptoms. Testosterone therapy can be administered in various forms, including injections, gels, patches, and pellets. However, it is important to note that testosterone therapy can have side effects, such as acne, hair loss, and an increased risk of blood clots, and should only be prescribed by a healthcare professional.

Juvenile hormones are a class of hormones that are produced by the endocrine glands of insects. These hormones play a crucial role in regulating the development and growth of insects, particularly during their larval stage. In insects, juvenile hormones are produced by the corpora allata, a gland located in the head of the insect. These hormones are transported to the target tissues, where they bind to specific receptors and initiate a cascade of signaling events that regulate various aspects of insect development, including growth, molting, and metamorphosis. Juvenile hormones are also involved in regulating the reproductive development of insects. In some species, they can stimulate the development of reproductive organs and the production of sex hormones, while in others, they can inhibit these processes. In the medical field, juvenile hormones have been studied for their potential use in controlling insect populations and as a source of therapeutic compounds. For example, some juvenile hormones have been shown to have anti-inflammatory and anti-cancer properties, and they are being investigated as potential treatments for these conditions.

Turner Syndrome is a genetic disorder that affects females and is caused by the complete or partial absence of one of the two X chromosomes. This results in a range of physical and developmental characteristics that can vary widely among affected individuals. Some common features of Turner Syndrome include short stature, webbed neck, low-set ears, broad chest, and a lack of secondary sexual characteristics such as breast development and menstruation. Affected individuals may also have heart defects, kidney abnormalities, and an increased risk of certain medical conditions such as diabetes and thyroid disorders. Treatment for Turner Syndrome typically involves hormone replacement therapy to promote the development of secondary sexual characteristics and to help with growth and development.

In the medical field, the term "cattle" refers to large domesticated animals that are raised for their meat, milk, or other products. Cattle are a common source of food and are also used for labor in agriculture, such as plowing fields or pulling carts. In veterinary medicine, cattle are often referred to as "livestock" and may be treated for a variety of medical conditions, including diseases, injuries, and parasites. Some common medical issues that may affect cattle include respiratory infections, digestive problems, and musculoskeletal disorders. Cattle may also be used in medical research, particularly in the fields of genetics and agriculture. For example, scientists may study the genetics of cattle to develop new breeds with desirable traits, such as increased milk production or resistance to disease.

Corticotropin-Releasing Hormone (CRH) is a peptide hormone that is produced by the paraventricular nucleus of the hypothalamus in the brain. It plays a key role in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is responsible for the body's response to stress. CRH stimulates the anterior pituitary gland to release adrenocorticotropic hormone (ACTH), which in turn stimulates the adrenal gland to produce cortisol. Cortisol is a stress hormone that helps the body respond to physical and emotional stress by increasing blood sugar levels, suppressing the immune system, and increasing blood pressure. CRH is also involved in other physiological processes, such as the regulation of appetite, metabolism, and the sleep-wake cycle. It is synthesized and secreted in response to stress, both physical and psychological, and plays a role in the body's response to trauma, illness, and other stressful events. In the medical field, CRH is used as a diagnostic tool to evaluate the function of the HPA axis and to diagnose certain disorders, such as Cushing's disease, which is characterized by excessive cortisol production. It is also used in research to study the effects of stress on the body and to develop new treatments for stress-related disorders.

In the medical field, body weight refers to the total mass of an individual's body, typically measured in kilograms (kg) or pounds (lbs). It is an important indicator of overall health and can be used to assess a person's risk for certain health conditions, such as obesity, diabetes, and heart disease. Body weight is calculated by measuring the amount of mass that a person's body contains, which includes all of the organs, tissues, bones, and fluids. It is typically measured using a scale or other weighing device, and can be influenced by factors such as age, gender, genetics, and lifestyle. Body weight can be further categorized into different types, such as body mass index (BMI), which takes into account both a person's weight and height, and waist circumference, which measures the size of a person's waist. These measures can provide additional information about a person's overall health and risk for certain conditions.

Receptors, Prolactin are proteins found on the surface of cells in the body that bind to the hormone prolactin and initiate a response within the cell. Prolactin is a hormone produced by the anterior pituitary gland that plays a role in lactation and breast development, as well as other functions such as immune system regulation and bone metabolism. The binding of prolactin to its receptors can stimulate the production of milk in the mammary glands, as well as other cellular responses depending on the type of cell and tissue involved.

Progesterone is a hormone that plays a crucial role in the female reproductive system. It is produced by the ovaries and the placenta during pregnancy and is responsible for preparing the uterus for pregnancy and maintaining the pregnancy. Progesterone also helps to regulate the menstrual cycle and can be used as a contraceptive. In addition to its reproductive functions, progesterone has a number of other effects on the body. It can help to reduce inflammation, promote bone density, and regulate mood. Progesterone is also used in medical treatment for a variety of conditions, including menopause, osteoporosis, and certain types of breast cancer. Progesterone is available as a medication in a variety of forms, including oral tablets, injections, and creams. It is important to note that progesterone can have side effects, including nausea, dizziness, and mood changes. It is important to discuss the potential risks and benefits of using progesterone with a healthcare provider before starting treatment.

Pancreatic hormones are hormones produced by the pancreas that play important roles in regulating various bodily functions. The pancreas is a glandular organ located in the abdomen, behind the stomach, and it produces both digestive enzymes and hormones. The main pancreatic hormones are: 1. Insulin: This hormone regulates blood sugar levels by promoting the uptake of glucose by cells and the storage of glucose in the liver and muscles. 2. Glucagon: This hormone raises blood sugar levels by stimulating the liver to release stored glucose into the bloodstream. 3. Somatostatin: This hormone inhibits the release of insulin and glucagon, as well as the production of digestive enzymes. 4. Pancreatic polypeptide: This hormone regulates appetite and digestion. 5. VIP (Vasoactive Intestinal Peptide): This hormone regulates the contraction and relaxation of smooth muscles in the digestive tract. Pancreatic hormones play a crucial role in maintaining normal blood sugar levels, regulating digestion, and controlling appetite. Imbalances in these hormones can lead to various medical conditions, such as diabetes, pancreatitis, and pancreatic cancer.

Recombinant proteins are proteins that are produced by genetically engineering bacteria, yeast, or other organisms to express a specific gene. These proteins are typically used in medical research and drug development because they can be produced in large quantities and are often more pure and consistent than proteins that are extracted from natural sources. Recombinant proteins can be used for a variety of purposes in medicine, including as diagnostic tools, therapeutic agents, and research tools. For example, recombinant versions of human proteins such as insulin, growth hormones, and clotting factors are used to treat a variety of medical conditions. Recombinant proteins can also be used to study the function of specific genes and proteins, which can help researchers understand the underlying causes of diseases and develop new treatments.

Somatomedins are a group of hormones that are produced by the liver and other tissues in response to growth hormone (GH) secreted by the anterior pituitary gland. There are five somatomedins: insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), insulin-like growth factor binding protein 1 (IGFBP-1), insulin-like growth factor binding protein 2 (IGFBP-2), and insulin-like growth factor binding protein 3 (IGFBP-3). Somatomedins play a crucial role in regulating growth and development in humans and other animals. They act on various tissues, including bone, muscle, and fat, to promote growth and cell division. In addition, somatomedins are involved in regulating metabolism, cell differentiation, and cell survival. Abnormal levels of somatomedins can lead to various medical conditions, including dwarfism, gigantism, and cancer. For example, mutations in the genes that encode for GH or its receptors can lead to growth disorders, while overproduction of somatomedins can contribute to the development of certain types of cancer.

Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) is a protein that plays a crucial role in regulating the growth and development of cells in the body. It is produced by various tissues, including the liver, muscle, and bone, and is secreted into the bloodstream. IGFBP-3 binds to insulin-like growth factors (IGFs), which are hormones that stimulate cell growth and division. By binding to IGFs, IGFBP-3 regulates their activity and helps to control the growth and development of cells. In addition to its role in cell growth and development, IGFBP-3 has been implicated in a number of other physiological processes, including bone metabolism, glucose metabolism, and immune function. It has also been studied in relation to a number of diseases, including cancer, diabetes, and osteoporosis. Overall, IGFBP-3 is an important protein that plays a critical role in regulating cell growth and development, and its function is closely tied to a number of other physiological processes in the body.

In the medical field, a base sequence refers to the specific order of nucleotides (adenine, thymine, cytosine, and guanine) that make up the genetic material (DNA or RNA) of an organism. The base sequence determines the genetic information encoded within the DNA molecule and ultimately determines the traits and characteristics of an individual. The base sequence can be analyzed using various techniques, such as DNA sequencing, to identify genetic variations or mutations that may be associated with certain diseases or conditions.

Pit-1 is a transcription factor that plays a critical role in the development and function of several endocrine glands, including the anterior pituitary gland. It is encoded by the POU1F1 gene and is a member of the POU family of transcription factors. Pit-1 is essential for the development of the anterior pituitary gland, as it regulates the expression of several genes that are necessary for the differentiation and function of pituitary cells. It is also involved in the regulation of growth hormone (GH) and thyroid-stimulating hormone (TSH) production. In addition to its role in pituitary gland development and function, Pit-1 has been implicated in the development of several diseases, including pituitary adenomas (benign tumors of the pituitary gland) and acromegaly (a disorder characterized by excessive GH production). Overall, Pit-1 is a critical transcription factor that plays a key role in the development and function of the anterior pituitary gland, and its dysregulation can lead to a variety of endocrine disorders.

Age determination by skeleton is a method used in forensic anthropology to estimate the age of a person based on the examination of their skeletal remains. This method is particularly useful in cases where the individual's body has decomposed or been destroyed, leaving only bones as evidence. The process of age determination by skeleton involves a detailed examination of the bones, including the skull, teeth, and long bones. The bones are analyzed for various characteristics that can provide clues about the individual's age, such as the degree of ossification (hardening) of the bones, the wear and tear on the teeth, and the presence of certain growth lines or markers. There are several different methods used to estimate age from skeletal remains, including the use of statistical models based on large datasets of known-age skeletons, as well as more individualized approaches based on the specific characteristics of the bones in question. The accuracy of age determination by skeleton can vary depending on a number of factors, including the quality of the bones, the degree of decomposition, and the expertise of the examiner.

Hypothalamic hormones are hormones that are produced by the hypothalamus, a small region of the brain that plays a critical role in regulating various bodily functions, including metabolism, growth, and reproduction. The hypothalamus produces several hormones that are involved in regulating the endocrine system, which is responsible for producing and secreting hormones throughout the body. Some of the most well-known hypothalamic hormones include: 1. Thyrotropin-releasing hormone (TRH): This hormone stimulates the pituitary gland to produce thyroid-stimulating hormone (TSH), which in turn stimulates the thyroid gland to produce thyroid hormones. 2. Corticotropin-releasing hormone (CRH): This hormone stimulates the pituitary gland to produce adrenocorticotropic hormone (ACTH), which in turn stimulates the adrenal gland to produce cortisol. 3. Gonadotropin-releasing hormone (GnRH): This hormone stimulates the pituitary gland to produce follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are involved in regulating the reproductive system. 4. Growth hormone-releasing hormone (GHRH): This hormone stimulates the pituitary gland to produce growth hormone (GH), which is involved in regulating growth and development. 5. Somatostatin: This hormone inhibits the production of several hormones, including GH, TSH, and ACTH. Hypothalamic hormones play a critical role in regulating various bodily functions, and imbalances in these hormones can lead to a range of health problems, including metabolic disorders, reproductive disorders, and endocrine disorders.

Pituitary Hormone-Releasing Hormones (PRHs) are a group of hormones that are produced by the hypothalamus, a region of the brain that controls many of the body's hormonal and metabolic processes. These hormones stimulate the pituitary gland, which is located at the base of the brain, to produce and release other hormones that regulate various bodily functions. There are several different types of PRHs, including thyrotropin-releasing hormone (TRH), corticotropin-releasing hormone (CRH), gonadotropin-releasing hormone (GnRH), growth hormone-releasing hormone (GHRH), and somatostatin-releasing hormone (SRH). Each of these hormones has a specific target hormone that it stimulates the pituitary gland to produce. For example, TRH stimulates the pituitary gland to produce thyroid-stimulating hormone (TSH), which in turn stimulates the thyroid gland to produce thyroid hormones. CRH stimulates the pituitary gland to produce adrenocorticotropic hormone (ACTH), which in turn stimulates the adrenal gland to produce cortisol. GnRH stimulates the pituitary gland to produce follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are important for reproductive function. GHRH stimulates the pituitary gland to produce growth hormone (GH), which is important for growth and development. SRH inhibits the production of several hormones, including GH and TSH. PRHs play a critical role in regulating many bodily functions, including growth and development, metabolism, reproduction, and stress response. Imbalances in the production or function of PRHs can lead to a variety of medical conditions, including hypothyroidism, Addison's disease, hypogonadism, dwarfism, and acromegaly.

Blood glucose, also known as blood sugar, is the level of glucose (a type of sugar) in the blood. Glucose is the primary source of energy for the body's cells, and it is produced by the liver and released into the bloodstream in response to the body's needs. In the medical field, blood glucose levels are often measured as part of a routine check-up or to monitor the health of people with diabetes or other conditions that affect blood sugar levels. Normal blood glucose levels for adults are typically between 70 and 100 milligrams per deciliter (mg/dL) before a meal and between 80 and 120 mg/dL two hours after a meal. Elevated blood glucose levels, also known as hyperglycemia, can be caused by a variety of factors, including diabetes, stress, certain medications, and high-carbohydrate meals. Low blood glucose levels, also known as hypoglycemia, can be caused by diabetes treatment that is too aggressive, skipping meals, or certain medications. Monitoring blood glucose levels is important for people with diabetes, as it helps them manage their condition and prevent complications such as nerve damage, kidney damage, and cardiovascular disease.

Hormone antagonists are medications that block or inhibit the effects of hormones in the body. They are often used in medical treatments to counteract the effects of hormones that are either overactive or underactive. Examples of hormone antagonists include: 1. Selective estrogen receptor modulators (SERMs): These medications block the effects of estrogen in some tissues but not others. They are used to treat conditions such as breast cancer and osteoporosis. 2. Progestins: These medications mimic the effects of the hormone progesterone and are used to treat conditions such as menopause symptoms and endometriosis. 3. Androgens: These medications block the effects of testosterone and are used to treat conditions such as prostate cancer and hirsutism (excessive hair growth in women). 4. Gonadotropin-releasing hormone (GnRH) antagonists: These medications block the release of gonadotropins, hormones that stimulate the ovaries and testes to produce sex hormones. They are used to treat conditions such as endometriosis and prostate cancer. Overall, hormone antagonists are an important tool in the medical field for treating a variety of conditions related to hormonal imbalances.

STAT5 (Signal Transducer and Activator of Transcription 5) is a transcription factor that plays a critical role in the regulation of gene expression in response to cytokines and growth factors. It is a member of the STAT family of proteins, which are involved in a variety of cellular processes, including cell growth, differentiation, and immune response. In the medical field, STAT5 is of particular interest because it is involved in the development and progression of several diseases, including cancer, autoimmune disorders, and inflammatory diseases. For example, STAT5 is often activated in cancer cells, and its overexpression has been linked to the development and progression of several types of cancer, including leukemia, lymphoma, and breast cancer. Additionally, STAT5 has been implicated in the development of autoimmune disorders, such as rheumatoid arthritis, and inflammatory diseases, such as inflammatory bowel disease. Overall, STAT5 is an important transcription factor that plays a critical role in regulating gene expression in response to cytokines and growth factors, and its dysregulation has been linked to the development and progression of several diseases.

Anti-Mullerian Hormone (AMH) is a hormone produced by granulosa cells in the ovaries. It plays a crucial role in the development and function of the female reproductive system. AMH levels are highest during fetal development and gradually decrease after birth. In women, AMH levels fluctuate throughout the menstrual cycle and are highest during the follicular phase, when the ovaries are preparing to release an egg. AMH is often used as a marker of ovarian reserve, which refers to the number and quality of eggs remaining in the ovaries. High levels of AMH are associated with a larger number of eggs, while low levels may indicate a lower ovarian reserve. AMH levels can also be used to diagnose conditions such as polycystic ovary syndrome (PCOS) and to monitor the effectiveness of fertility treatments.

Thyrotropin-Releasing Hormone (TRH) is a hormone produced by the hypothalamus, a region of the brain that plays a crucial role in regulating various bodily functions, including metabolism, growth, and development. TRH is responsible for stimulating the release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland, which in turn stimulates the thyroid gland to produce thyroid hormones. Thyroid hormones are essential for regulating metabolism, growth, and development in the body. They help to regulate the body's energy levels, maintain body temperature, and support the growth and development of tissues and organs. TRH is also involved in regulating the sleep-wake cycle, appetite, and mood. It is often used in medical treatments for conditions such as hypothyroidism, which is a condition characterized by low levels of thyroid hormones, and for disorders of the sleep-wake cycle, such as insomnia.

Gonadal hormones are hormones produced by the gonads, which are the testes in males and the ovaries in females. These hormones play a crucial role in the development and maintenance of reproductive function in both males and females. In males, the primary gonadal hormone is testosterone, which is responsible for the development of male secondary sexual characteristics such as facial hair, deepening of the voice, and muscle mass. Testosterone also plays a role in sperm production and sexual desire. In females, the primary gonadal hormones are estrogen and progesterone. Estrogen is responsible for the development of female secondary sexual characteristics such as breast development and the menstrual cycle. Progesterone is responsible for preparing the uterus for pregnancy and maintaining pregnancy. Gonadal hormones also play a role in other bodily functions such as bone health, mood regulation, and immune function. Imbalances in gonadal hormones can lead to a variety of medical conditions, including infertility, osteoporosis, and mood disorders.

Laron syndrome is a rare genetic disorder that affects growth and metabolism. It is caused by a mutation in the growth hormone receptor gene, which leads to a deficiency in growth hormone (GH) signaling. People with Laron syndrome have short stature, a small head, and a distinctive appearance, including a long, narrow face and a large tongue. They also have insulin resistance and may develop diabetes. The syndrome is usually diagnosed in early childhood and is treated with a low-calorie diet and regular exercise to help manage symptoms.

Thyroid Hormone Receptors beta (TRβ) are a type of nuclear hormone receptor that are activated by thyroid hormones, such as triiodothyronine (T3) and thyroxine (T4). These receptors are expressed in a wide range of tissues throughout the body, including the brain, heart, muscles, and adipose tissue. TRβ receptors play a critical role in regulating metabolism, growth, and development. When thyroid hormones bind to TRβ receptors, they can either activate or repress the expression of genes involved in these processes. This can lead to changes in the body's energy metabolism, heart rate, body temperature, and other physiological functions. In the medical field, TRβ receptors are often studied in the context of thyroid disorders, such as hypothyroidism and hyperthyroidism. Abnormalities in TRβ receptor function can contribute to the development of these conditions, and targeted therapies that modulate TRβ receptor activity are being investigated as potential treatments. Additionally, TRβ receptors are also being studied in the context of other diseases, such as cancer and diabetes, as they may play a role in regulating these conditions as well.

Receptors, Neuropeptide are proteins found on the surface of cells in the nervous system that bind to specific neuropeptides, which are signaling molecules that transmit information between neurons. These receptors play a crucial role in regulating various physiological processes, including mood, pain, appetite, and stress response. Activation of neuropeptide receptors can lead to changes in gene expression, intracellular signaling pathways, and cellular function, ultimately resulting in changes in behavior and physiology. Dysregulation of neuropeptide receptors has been implicated in various neurological and psychiatric disorders, including depression, anxiety, addiction, and pain.

Hypothyroidism is a medical condition in which the thyroid gland does not produce enough thyroid hormones. The thyroid gland is a small gland located in the neck that plays a crucial role in regulating the body's metabolism. When the thyroid gland does not produce enough hormones, the body's metabolism slows down, leading to a range of symptoms such as fatigue, weight gain, cold intolerance, dry skin, hair loss, constipation, and depression. Hypothyroidism can be caused by a variety of factors, including autoimmune disorders, iodine deficiency, radiation therapy, surgery, and certain medications. It is typically diagnosed through blood tests that measure the levels of thyroid hormones in the body. Treatment for hypothyroidism typically involves taking synthetic thyroid hormone medication to replace the hormones that the body is not producing enough of. With proper treatment, most people with hypothyroidism can manage their symptoms and live normal, healthy lives.

Glucagon is a hormone produced by the alpha cells of the pancreas. It plays a crucial role in regulating blood glucose levels in the body. When blood glucose levels are low, such as during fasting or prolonged exercise, the pancreas releases glucagon into the bloodstream. Glucagon signals the liver to break down stored glycogen into glucose and release it into the bloodstream, thereby increasing blood glucose levels. In addition to its role in regulating blood glucose levels, glucagon also has other functions in the body. It can stimulate the breakdown of fats in adipose tissue and increase the release of fatty acids into the bloodstream. It can also stimulate the breakdown of proteins in muscle tissue and increase the release of amino acids into the bloodstream. Glucagon is used in medical treatment for a variety of conditions, including type 1 diabetes, hypoglycemia, and certain types of liver disease. It is typically administered as an injection or infusion.

Gastrointestinal hormones are chemical messengers produced by cells in the lining of the gastrointestinal tract that regulate various functions of the digestive system, including appetite, digestion, and absorption of nutrients. These hormones are secreted in response to various stimuli, such as the presence of food in the stomach or the stretching of the gut wall. Some examples of gastrointestinal hormones include gastrin, secretin, cholecystokinin, and ghrelin. Gastrin stimulates the production of stomach acid and the release of digestive enzymes, while secretin and cholecystokinin help regulate the release of bile from the liver and the movement of food through the digestive tract. Ghrelin, on the other hand, is involved in regulating appetite and energy balance. Gastrointestinal hormones play a crucial role in maintaining the normal functioning of the digestive system and are often studied in the context of various digestive disorders, such as gastrointestinal ulcers, inflammatory bowel disease, and obesity.

In the medical field, a cell line refers to a group of cells that have been derived from a single parent cell and have the ability to divide and grow indefinitely in culture. These cells are typically grown in a laboratory setting and are used for research purposes, such as studying the effects of drugs or investigating the underlying mechanisms of diseases. Cell lines are often derived from cancerous cells, as these cells tend to divide and grow more rapidly than normal cells. However, they can also be derived from normal cells, such as fibroblasts or epithelial cells. Cell lines are characterized by their unique genetic makeup, which can be used to identify them and compare them to other cell lines. Because cell lines can be grown in large quantities and are relatively easy to maintain, they are a valuable tool in medical research. They allow researchers to study the effects of drugs and other treatments on specific cell types, and to investigate the underlying mechanisms of diseases at the cellular level.

Sermorelin is a synthetic peptide that is similar in structure to the naturally occurring hormone somatotropin (also known as growth hormone or GH). It is used in medical research and treatment to stimulate the production of growth hormone in the body. Sermorelin is typically administered by injection and is used to treat conditions such as growth hormone deficiency, Turner syndrome, and short stature in children. It may also be used to promote muscle growth and improve body composition in athletes. Sermorelin is a controlled substance and requires a prescription from a qualified healthcare provider. It is important to follow the recommended dosage and administration instructions carefully to avoid potential side effects.

Gigantism is a rare medical condition characterized by excessive growth and height due to an overproduction of growth hormone (GH) by the pituitary gland. The pituitary gland is a small gland located at the base of the brain that produces hormones that regulate various bodily functions, including growth and development. In gigantism, the overproduction of GH leads to an increase in the size of bones and cartilage, resulting in excessive growth and height. This condition usually occurs during childhood or adolescence, and affected individuals may grow to be much taller than their peers. Gigantism can also cause other symptoms, such as enlarged hands and feet, thickening of the facial features, and an enlarged tongue. In some cases, gigantism can also lead to health problems such as high blood pressure, diabetes, and sleep apnea. Treatment for gigantism typically involves surgery to remove the pituitary tumor that is causing the overproduction of GH. In some cases, medications may also be used to reduce GH levels and slow down growth.

Glycoprotein hormones, alpha subunit are a group of hormones that are composed of two subunits: an alpha subunit and a hormone-specific beta subunit. The alpha subunit is a common component of several different glycoprotein hormones, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The alpha subunit is encoded by a single gene and is synthesized in the pituitary gland. It is then cleaved from the larger glycoprotein hormone molecule, leaving behind the hormone-specific beta subunit. The alpha subunit is responsible for binding to specific receptors on the surface of target cells, allowing the hormone-specific beta subunit to exert its effects. Glycoprotein hormones, alpha subunit are important regulators of various physiological processes, including growth and development, metabolism, and reproduction. They are often used as diagnostic markers in medical testing and are also used in the treatment of various medical conditions, such as infertility and thyroid disorders.

Body composition refers to the proportion of different types of tissue in the human body, including fat, muscle, bone, and water. It is an important measure of overall health and can be used to assess changes in weight and body shape over time. In the medical field, body composition is often measured using various techniques such as dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and skinfold measurements. These methods can provide information about an individual's body fat percentage, lean body mass, and bone density, which can be used to diagnose and monitor a variety of medical conditions, including obesity, osteoporosis, and metabolic disorders.

Milk proteins are the proteins found in milk, which are responsible for its nutritional value and various functional properties. These proteins are a mixture of casein and whey proteins, which are further broken down into different types of proteins such as alpha-casein, beta-casein, and lactalbumin. In the medical field, milk proteins are often used as a source of nutrition for patients who are unable to consume solid foods or have difficulty digesting other types of protein sources. Milk proteins are also used in the production of various medical products such as intravenous solutions, nutritional supplements, and medical foods. Milk proteins have been shown to have various health benefits, including improving bone health, supporting immune function, and reducing the risk of certain diseases such as heart disease and type 2 diabetes. However, some people may be allergic to milk proteins or have difficulty digesting them, which can lead to symptoms such as bloating, gas, and diarrhea.

In the medical field, "Fatty Acids, Nonesterified" refers to free fatty acids that are not bound to glycerol in triglycerides. These fatty acids are found in the bloodstream and are an important source of energy for the body. They can be obtained from dietary fats or synthesized by the liver and adipose tissue. Nonesterified fatty acids are also involved in various physiological processes, such as the regulation of insulin sensitivity and the production of signaling molecules. Abnormal levels of nonesterified fatty acids in the blood can be associated with various medical conditions, including diabetes, obesity, and cardiovascular disease.

In the medical field, an amino acid sequence refers to the linear order of amino acids in a protein molecule. Proteins are made up of chains of amino acids, and the specific sequence of these amino acids determines the protein's structure and function. The amino acid sequence is determined by the genetic code, which is a set of rules that specifies how the sequence of nucleotides in DNA is translated into the sequence of amino acids in a protein. Each amino acid is represented by a three-letter code, and the sequence of these codes is the amino acid sequence of the protein. The amino acid sequence is important because it determines the protein's three-dimensional structure, which in turn determines its function. Small changes in the amino acid sequence can have significant effects on the protein's structure and function, and this can lead to diseases or disorders. For example, mutations in the amino acid sequence of a protein involved in blood clotting can lead to bleeding disorders.

In the medical field, "Cells, Cultured" refers to cells that have been grown and maintained in a controlled environment outside of their natural biological context, typically in a laboratory setting. This process is known as cell culture and involves the isolation of cells from a tissue or organism, followed by their growth and proliferation in a nutrient-rich medium. Cultured cells can be derived from a variety of sources, including human or animal tissues, and can be used for a wide range of applications in medicine and research. For example, cultured cells can be used to study the behavior and function of specific cell types, to develop new drugs and therapies, and to test the safety and efficacy of medical products. Cultured cells can be grown in various types of containers, such as flasks or Petri dishes, and can be maintained at different temperatures and humidity levels to optimize their growth and survival. The medium used to culture cells typically contains a combination of nutrients, growth factors, and other substances that support cell growth and proliferation. Overall, the use of cultured cells has revolutionized medical research and has led to many important discoveries and advancements in the field of medicine.

Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins that bind to insulin-like growth factors (IGFs) and regulate their activity. There are six different IGFBPs, each with a distinct structure and function. IGFBPs play an important role in regulating cell growth, differentiation, and survival. They can either enhance or inhibit the effects of IGFs, depending on the specific IGFBP and the cellular context. In the medical field, IGFBPs have been studied in relation to various diseases, including cancer, osteoporosis, and diabetes. For example, some studies have suggested that altered levels of IGFBPs may be involved in the development and progression of certain types of cancer. Additionally, IGFBPs have been investigated as potential therapeutic targets for the treatment of these diseases.

Thyroid Hormone Receptors alpha (TRα) are a type of nuclear hormone receptor that are activated by thyroid hormones, such as triiodothyronine (T3) and thyroxine (T4). These receptors are found in many tissues throughout the body, including the brain, heart, muscles, and bones. When thyroid hormones bind to TRα receptors, they can regulate gene expression, which can affect a wide range of physiological processes, including metabolism, growth and development, and body temperature regulation. In the thyroid gland, TRα receptors play a critical role in regulating the production and release of thyroid hormones. Abnormalities in TRα receptors can lead to a variety of thyroid disorders, including hypothyroidism (low levels of thyroid hormones) and hyperthyroidism (high levels of thyroid hormones). These disorders can have a significant impact on a person's health and well-being, and may require medical treatment.

Receptors, Thyrotropin-Releasing Hormone (TRH) are proteins found on the surface of cells in the body that bind to and respond to the hormone thyrotropin-releasing hormone (TRH). TRH is a hormone produced by the hypothalamus, a region of the brain, and is involved in regulating the production of thyroid hormones by the thyroid gland. When TRH binds to its receptors on thyroid cells, it stimulates the production and release of thyroid-stimulating hormone (TSH), which in turn stimulates the thyroid gland to produce thyroid hormones. These hormones are important for regulating metabolism and energy production in the body.

Craniopharyngioma is a rare, slow-growing benign tumor that develops in the craniopharyngeal region, which is the area where the brain meets the pituitary gland. It is classified into two types: adamantinomatous and papillary. The tumor can cause a variety of symptoms, including headaches, vision problems, hormonal imbalances, and changes in appetite and weight. It can also cause fluid buildup in the brain, leading to increased pressure and potentially life-threatening complications. Treatment options for craniopharyngioma include surgery, radiation therapy, and medication to manage symptoms. The choice of treatment depends on the size and location of the tumor, as well as the patient's overall health and preferences.

Insect hormones are chemical messengers that regulate various physiological processes in insects, such as growth, development, reproduction, and behavior. These hormones are produced by glands in the insect's body and are transported through the hemolymph, the insect's equivalent of blood. There are several types of insect hormones, including ecdysteroids, juvenile hormones, and sex hormones. Ecdysteroids are responsible for regulating molting and metamorphosis in insects, while juvenile hormones control the development of immature insects into adults. Sex hormones, such as pheromones, are involved in sexual behavior and reproduction. Insect hormones play a crucial role in the life cycle of insects and are often used in pest control and management strategies. For example, insecticides that mimic or block the effects of insect hormones can be used to disrupt insect development or behavior, making them less harmful to crops or humans. Additionally, researchers are studying insect hormones as potential targets for new drugs to treat human diseases, such as cancer and diabetes.

Pituitary diseases refer to disorders that affect the pituitary gland, a small endocrine gland located at the base of the brain. The pituitary gland plays a crucial role in regulating various bodily functions, including growth, metabolism, and reproduction, through the production and release of hormones. Pituitary diseases can be classified into two main categories: functional and non-functional. Functional pituitary diseases occur when the pituitary gland produces too much or too little of a hormone, leading to imbalances in the body's hormonal system. Examples of functional pituitary diseases include: 1. Hyperpituitarism: This occurs when the pituitary gland produces too much of one or more hormones, leading to symptoms such as excessive growth, weight gain, and irregular menstrual periods in women. 2. Hypopituitarism: This occurs when the pituitary gland produces too little of one or more hormones, leading to symptoms such as fatigue, weight loss, and infertility. Non-functional pituitary diseases, on the other hand, occur when the pituitary gland does not produce enough hormones or when there is a problem with the gland itself. Examples of non-functional pituitary diseases include: 1. Pituitary adenoma: This is a benign tumor that develops in the pituitary gland, causing hormonal imbalances and potentially leading to headaches, vision problems, and hormonal symptoms. 2. Sheehan's syndrome: This occurs when the pituitary gland is damaged due to childbirth or other causes, leading to hormonal imbalances and symptoms such as fatigue, weight loss, and infertility. Treatment for pituitary diseases depends on the specific type and severity of the condition. Treatment options may include medication, surgery, radiation therapy, or hormone replacement therapy.

Invertebrate hormones are chemical messengers produced by glands in invertebrates, such as insects, crustaceans, mollusks, and worms. These hormones play a crucial role in regulating various physiological processes, including growth and development, reproduction, metabolism, and behavior. Invertebrate hormones can be classified into different types based on their chemical structure and function. Some examples of invertebrate hormones include: * Ecdysteroids: These hormones are involved in regulating molting and metamorphosis in insects and crustaceans. * JH (Juvenile Hormone): This hormone is involved in regulating growth and development in insects. * Melatonin: This hormone is involved in regulating the sleep-wake cycle in many invertebrates. * Octopamine: This hormone is involved in regulating metabolism, feeding behavior, and aggression in insects and crustaceans. * Serotonin: This hormone is involved in regulating mood, appetite, and sleep in many invertebrates. Invertebrate hormones are studied in the medical field because they can provide insights into the evolution of endocrine systems and the mechanisms underlying various physiological processes. Additionally, some invertebrate hormones have potential therapeutic applications in medicine, such as in the treatment of sleep disorders or the regulation of metabolism.

An adenoma is a benign (non-cancerous) tumor that develops from glandular cells. It is a type of neoplasm, which is an abnormal growth of cells. Adenomas can occur in various parts of the body, including the colon, rectum, breast, thyroid gland, and prostate gland. In the colon and rectum, adenomas are commonly referred to as polyps. They can vary in size and shape and may or may not cause symptoms. However, some adenomas can develop into cancer if left untreated, which is why they are often removed during a colonoscopy or other screening tests. In other parts of the body, adenomas may cause symptoms depending on their location and size. For example, an adenoma in the thyroid gland may cause a goiter, while an adenoma in the prostate gland may cause difficulty urinating. Treatment for adenomas depends on their size, location, and whether they are causing symptoms. Small adenomas may not require treatment, while larger ones may be removed through surgery or other procedures. In some cases, medication may be used to shrink the adenoma or prevent it from growing back.

Dexamethasone is a synthetic glucocorticoid hormone that is used in the medical field as an anti-inflammatory, immunosuppressive, and antipyretic agent. It is a potent corticosteroid that has a wide range of therapeutic applications, including the treatment of allergic reactions, inflammatory diseases, autoimmune disorders, and cancer. Dexamethasone is available in various forms, including tablets, injections, and inhalers, and is used to treat a variety of conditions, such as asthma, COPD, rheumatoid arthritis, lupus, multiple sclerosis, and inflammatory bowel disease. It is also used to treat severe cases of COVID-19, as it has been shown to reduce inflammation and improve outcomes in patients with severe illness. However, dexamethasone is a potent drug that can have significant side effects, including weight gain, fluid retention, high blood pressure, increased risk of infection, and mood changes. Therefore, it is typically prescribed only when other treatments have failed or when the potential benefits outweigh the risks.

Pituitary hormones, posterior refers to a group of hormones produced by the posterior lobe of the pituitary gland, which is located at the base of the brain. The posterior lobe is responsible for producing and releasing two hormones: adrenocorticotropic hormone (ACTH) and thyroid-stimulating hormone (TSH). ACTH stimulates the adrenal gland to produce cortisol, a hormone that helps the body respond to stress and regulates metabolism. TSH, on the other hand, stimulates the thyroid gland to produce thyroid hormones, which regulate metabolism, growth, and development. Abnormalities in the production or secretion of these hormones can lead to a variety of medical conditions, including Cushing's disease (caused by excessive ACTH production), Addison's disease (caused by insufficient ACTH production), and hypothyroidism (caused by insufficient TSH production).

Hypothalamic diseases refer to disorders that affect the hypothalamus, a small but crucial region of the brain that plays a vital role in regulating various bodily functions, including metabolism, appetite, thirst, body temperature, and sleep. The hypothalamus is also responsible for controlling the release of hormones from the pituitary gland, which in turn regulates other endocrine glands in the body. Hypothalamic diseases can be caused by a variety of factors, including genetic mutations, infections, trauma, tumors, and autoimmune disorders. Some common examples of hypothalamic diseases include: 1. Hypothalamic obesity: A condition characterized by excessive weight gain due to hormonal imbalances in the hypothalamus. 2. Hypothalamic amenorrhea: A condition in which menstrual periods stop due to hormonal imbalances in the hypothalamus. 3. Hypothalamic diabetes insipidus: A condition characterized by excessive thirst and urination due to a deficiency of the hormone vasopressin, which is produced by the hypothalamus. 4. Hypothalamic hypopituitarism: A condition in which the pituitary gland fails to produce one or more of its hormones due to damage to the hypothalamus. 5. Hypothalamic tumors: Tumors that develop in the hypothalamus can cause a variety of symptoms, including hormonal imbalances, changes in appetite and weight, and neurological problems. Treatment for hypothalamic diseases depends on the underlying cause and the specific symptoms experienced by the patient. In some cases, hormone replacement therapy may be necessary to correct hormonal imbalances. In other cases, surgery or radiation therapy may be used to treat tumors or other structural abnormalities in the hypothalamus.

In the medical field, aging refers to the natural process of physical, biological, and psychological changes that occur over time in living organisms, including humans. These changes can affect various aspects of an individual's health and well-being, including their metabolism, immune system, cardiovascular system, skeletal system, and cognitive function. Aging is a complex process that is influenced by a combination of genetic, environmental, and lifestyle factors. As people age, their bodies undergo a gradual decline in function, which can lead to the development of age-related diseases and conditions such as arthritis, osteoporosis, cardiovascular disease, diabetes, and dementia. In the medical field, aging is studied in the context of geriatrics, which is the branch of medicine that focuses on the health and well-being of older adults. Geriatricians work to identify and manage age-related health issues, promote healthy aging, and improve the quality of life for older adults.

Adipose tissue, also known as body fat or adipose tissue, is a specialized type of connective tissue that is found throughout the body. It is composed of adipocytes, which are cells that store energy in the form of fat. Adipose tissue plays a number of important roles in the body, including insulation, energy storage, and hormone regulation. It is also an important component of the immune system and helps to regulate blood pressure and blood sugar levels. In addition to its physiological functions, adipose tissue also plays a role in the development of certain diseases, such as obesity and type 2 diabetes.

Gonadotropins, Pituitary are hormones produced by the anterior pituitary gland that regulate the function of the gonads (testes in males and ovaries in females). These hormones are responsible for controlling the production of sex hormones and the development of secondary sexual characteristics. There are two main types of gonadotropins: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH stimulates the production of testosterone in males and estrogen and progesterone in females. It also triggers ovulation in females. FSH, on the other hand, stimulates the growth and maturation of ovarian follicles in females and sperm production in males. Gonadotropins, Pituitary are often used in medical treatments to stimulate ovulation in women who are having difficulty conceiving or to treat infertility. They may also be used to treat certain types of cancer, such as prostate cancer or breast cancer.

DNA, or deoxyribonucleic acid, is a molecule that carries genetic information in living organisms. It is composed of four types of nitrogen-containing molecules called nucleotides, which are arranged in a specific sequence to form the genetic code. In the medical field, DNA is often studied as a tool for understanding and diagnosing genetic disorders. Genetic disorders are caused by changes in the DNA sequence that can affect the function of genes, leading to a variety of health problems. By analyzing DNA, doctors and researchers can identify specific genetic mutations that may be responsible for a particular disorder, and develop targeted treatments or therapies to address the underlying cause of the condition. DNA is also used in forensic science to identify individuals based on their unique genetic fingerprint. This is because each person's DNA sequence is unique, and can be used to distinguish one individual from another. DNA analysis is also used in criminal investigations to help solve crimes by linking DNA evidence to suspects or victims.

Melanocyte-stimulating hormones (MSH) are a group of peptides that are produced by the anterior pituitary gland and the hypothalamus in the brain. They play a role in regulating the production of melanin, a pigment that gives color to the skin, hair, and eyes. MSH also has other functions, such as regulating appetite, metabolism, and stress response. There are two main types of MSH: alpha-MSH and beta-MSH. Alpha-MSH is the more potent of the two and is responsible for stimulating the production of melanin. Beta-MSH has a weaker effect on melanin production and is primarily involved in regulating appetite and metabolism. MSH is produced by specialized cells in the brain called melanotrophs, which are located in the anterior pituitary gland. These cells release MSH into the bloodstream, where it travels to the skin and other organs to exert its effects. Abnormalities in MSH production or function can lead to a variety of medical conditions, including skin disorders, obesity, and mood disorders. For example, a deficiency in MSH can cause albinism, a genetic disorder characterized by a lack of pigmentation in the skin, hair, and eyes. On the other hand, an excess of MSH can lead to excessive pigmentation, which can cause skin discoloration and other skin problems.

Testicular hormones are hormones produced by the testes in males. The primary hormones produced by the testes are testosterone and luteinizing hormone (LH). Testosterone is responsible for the development of male secondary sexual characteristics, such as facial hair, deepening of the voice, and muscle mass. LH stimulates the production of testosterone by the testes. Testicular hormones also play a role in sperm production and sexual function.

Janus kinase 2 (JAK2) is a protein that plays a role in the signaling pathways of many different cell types in the body. It is a member of the Janus kinase family of enzymes, which are involved in the regulation of cell growth, differentiation, and immune function. In the context of the medical field, JAK2 is of particular interest because it has been implicated in the development of certain blood disorders, such as myeloproliferative neoplasms (MPNs). MPNs are a group of blood cancers that involve the overproduction of blood cells, such as red blood cells, white blood cells, or platelets. JAK2 mutations have been identified in a large proportion of patients with MPNs, and these mutations are thought to contribute to the development and progression of the disease. JAK2 inhibitors are a class of drugs that have been developed to target the JAK2 enzyme and are being used to treat certain types of MPNs. These drugs work by blocking the activity of JAK2, which helps to reduce the overproduction of blood cells and alleviate the symptoms of the disease.

Leptin is a hormone that is produced by fat cells and plays a role in regulating appetite and metabolism. It helps to signal the brain when the body has enough energy stores and can therefore reduce hunger and increase energy expenditure. Leptin also plays a role in regulating the body's immune system and has been linked to a number of other physiological processes, including reproduction and bone health. In the medical field, leptin is often studied in relation to obesity and other metabolic disorders, as well as in the treatment of these conditions.

Follicle-stimulating hormone (FSH) is a glycoprotein hormone secreted by the anterior pituitary gland. It plays a crucial role in the regulation of the menstrual cycle, sperm production, and the development of ovarian follicles. The beta subunit of FSH is a protein that is common to all glycoprotein hormones, including FSH, luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and chorionic gonadotropin (hCG). The beta subunit is responsible for binding to the specific receptors on the target cells, allowing the hormone to exert its effects.

A biological assay is a laboratory technique used to measure the biological activity of a substance, such as a drug or a protein. It involves exposing a biological system, such as cells or tissues, to the substance and measuring the resulting response. The response can be anything from a change in cell growth or survival to a change in gene expression or protein activity. Biological assays are used in a variety of fields, including pharmacology, toxicology, and biotechnology, to evaluate the effectiveness and safety of drugs, to study the function of genes and proteins, and to develop new therapeutic agents.

Hypoglycemia is a medical condition characterized by low blood sugar levels (glucose). It occurs when the body produces too much insulin or when the body cannot use insulin properly, leading to a decrease in blood glucose levels. Symptoms of hypoglycemia can include dizziness, weakness, confusion, irritability, shakiness, sweating, rapid heartbeat, and hunger. In severe cases, hypoglycemia can lead to seizures, loss of consciousness, and even coma. Hypoglycemia is typically treated by consuming foods or drinks that contain sugar or other carbohydrates, which can quickly raise blood glucose levels. In some cases, medications may be prescribed to help regulate blood sugar levels. Hypoglycemia can be a serious condition, especially for people with diabetes who rely on insulin to manage their blood sugar levels. It is important for individuals with diabetes to monitor their blood sugar levels regularly and to have a plan in place for treating hypoglycemia if it occurs.

The Receptor, Parathyroid Hormone, Type 1 (PTH1R) is a protein that acts as a receptor for parathyroid hormone (PTH), a hormone produced by the parathyroid glands. PTH1R is expressed in a variety of tissues, including bone, kidney, and the small intestine, and plays a critical role in regulating calcium and phosphate homeostasis in the body. PTH1R belongs to the G protein-coupled receptor (GPCR) family, which is a large group of proteins that respond to a wide range of signaling molecules, including hormones, neurotransmitters, and sensory stimuli. When PTH binds to PTH1R, it triggers a signaling cascade that involves the activation of intracellular G proteins, which in turn activate various downstream signaling pathways. The activation of PTH1R has been shown to play a critical role in the regulation of bone metabolism, including the stimulation of bone resorption and the inhibition of bone formation. It also plays a role in the regulation of calcium and phosphate homeostasis in the kidney, where it promotes the reabsorption of calcium and the excretion of phosphate. Disruptions in the function of PTH1R can lead to a variety of disorders, including hypoparathyroidism, which is characterized by low levels of PTH and hypocalcemia, and hyperparathyroidism, which is characterized by high levels of PTH and hypercalcemia.

Oxandrolone is a synthetic anabolic steroid that is used in the medical field to treat certain conditions, such as muscle wasting due to cancer, HIV/AIDS, or kidney or liver disease. It is also used to promote bone growth in people with osteoporosis or to treat delayed puberty in boys. Oxandrolone works by increasing the production of proteins in the body, which can help to build muscle and increase bone density. It is usually taken orally in the form of tablets. Like all anabolic steroids, oxandrolone can have side effects, including acne, hair loss, and changes in cholesterol levels. It is important to use oxandrolone only under the guidance of a healthcare professional, as it can interact with other medications and may not be safe for everyone to use.

Chorionic Gonadotropin (hCG) is a hormone produced by the placenta during pregnancy. It is responsible for maintaining the corpus luteum, which produces progesterone to support the pregnancy. hCG is also used as a diagnostic tool in medicine to detect pregnancy, as well as to monitor the progress of the pregnancy and detect any potential complications. In some cases, hCG may also be used to treat certain medical conditions, such as certain types of cancer.

Receptors, cell surface are proteins that are located on the surface of cells and are responsible for receiving signals from the environment. These signals can be chemical, electrical, or mechanical in nature and can trigger a variety of cellular responses. There are many different types of cell surface receptors, including ion channels, G-protein coupled receptors, and enzyme-linked receptors. These receptors play a critical role in many physiological processes, including sensation, communication, and regulation of cellular activity. In the medical field, understanding the function and regulation of cell surface receptors is important for developing new treatments for a wide range of diseases and conditions.

Corticosterone is a steroid hormone produced by the adrenal cortex in response to stress. It plays a key role in the body's stress response and helps regulate metabolism, immune function, and blood pressure. Corticosterone is also involved in the development and maintenance of bone tissue, and it has anti-inflammatory effects. In the medical field, corticosterone is used to treat a variety of conditions, including adrenal insufficiency, allergies, and autoimmune disorders. It is available as a prescription medication and is typically administered orally or by injection.

Bone development, also known as osteogenesis, is the process by which bones grow and mature. It involves the differentiation of mesenchymal stem cells into osteoblasts, which are specialized cells that produce bone matrix. The bone matrix is a composite of collagen fibers and minerals, including calcium and phosphate, that give bones their strength and rigidity. During bone development, osteoblasts secrete bone matrix, which is then mineralized with calcium and phosphate. As the bone matrix mineralizes, osteoblasts differentiate into osteocytes, which are mature bone cells that are embedded within the bone matrix. Osteocytes are responsible for maintaining bone health by regulating bone resorption and formation. Bone development occurs throughout life, with the highest rates of bone growth occurring during childhood and adolescence. However, bone development is not complete until the early 20s, and bone continues to be remodeled and strengthened throughout life through a process called bone remodeling. Disruptions in bone development can lead to a variety of bone disorders, including osteogenesis imperfecta, which is a genetic disorder characterized by brittle bones, and rickets, which is a vitamin D deficiency that can lead to soft and weak bones.

Receptors, LHRH (Luteinizing Hormone-Releasing Hormone Receptors) are proteins found on the surface of cells in the body that bind to and respond to Luteinizing Hormone-Releasing Hormone (LHRH), also known as Gonadotropin-Releasing Hormone (GnRH). These receptors are primarily located in the hypothalamus, pituitary gland, and gonads (ovaries and testes) and play a crucial role in regulating the production and release of hormones in the endocrine system. LHRH is a hormone produced by the hypothalamus that stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn regulate the reproductive system. When LHRH binds to its receptors on these cells, it triggers a signaling cascade that leads to the production and release of LH and FSH. Receptors, LHRH are also found in other tissues throughout the body, including the breast, prostate, and uterus, where they may play a role in regulating other physiological processes. Disruptions in the function or expression of LHRH receptors can lead to a variety of medical conditions, including infertility, menstrual disorders, and prostate cancer.

Circadian rhythm refers to the internal biological clock that regulates various physiological processes in the body, including sleep-wake cycles, body temperature, hormone production, and metabolism. This rhythm is controlled by a group of neurons in the hypothalamus called the suprachiasmatic nucleus (SCN), which receives input from specialized photoreceptors in the retina that detect changes in light levels. The circadian rhythm is approximately 24 hours long and is influenced by external factors such as light exposure, meal times, and physical activity. Disruptions to the circadian rhythm, such as those caused by jet lag, shift work, or chronic sleep disorders, can have negative effects on health and well-being, including increased risk of mood disorders, cardiovascular disease, and metabolic disorders such as diabetes.

In the medical field, carrier proteins are proteins that transport molecules across cell membranes or within cells. These proteins bind to specific molecules, such as hormones, nutrients, or waste products, and facilitate their movement across the membrane or within the cell. Carrier proteins play a crucial role in maintaining the proper balance of molecules within cells and between cells. They are involved in a wide range of physiological processes, including nutrient absorption, hormone regulation, and waste elimination. There are several types of carrier proteins, including facilitated diffusion carriers, active transport carriers, and ion channels. Each type of carrier protein has a specific function and mechanism of action. Understanding the role of carrier proteins in the body is important for diagnosing and treating various medical conditions, such as genetic disorders, metabolic disorders, and neurological disorders.

Receptors, Parathyroid Hormone (PTH) are proteins found on the surface of cells in the body that bind to and respond to parathyroid hormone (PTH), a hormone produced by the parathyroid glands. PTH plays a crucial role in regulating calcium and phosphorus levels in the body, and its receptors are involved in this process. PTH receptors are classified into two types: membrane-bound receptors and intracellular receptors. Membrane-bound receptors are located on the surface of cells and are activated when PTH binds to them, leading to a cascade of intracellular signaling events that ultimately affect calcium and phosphorus metabolism. Intracellular receptors, on the other hand, are located inside the cell and are activated when PTH binds to them, leading to changes in gene expression and protein synthesis. PTH receptors are found in a variety of tissues throughout the body, including bone, kidney, and the gastrointestinal tract. In the bone, PTH receptors are involved in the regulation of bone resorption, or the breakdown of bone tissue, and bone formation. In the kidney, PTH receptors are involved in the regulation of calcium and phosphorus excretion. In the gastrointestinal tract, PTH receptors are involved in the regulation of phosphate absorption. Disruptions in PTH receptor function can lead to a variety of medical conditions, including hypoparathyroidism (low levels of PTH), hyperparathyroidism (high levels of PTH), and pseudohypoparathyroidism (a genetic disorder that affects PTH receptor function).

Steroid 16-alpha-hydroxylase is an enzyme that plays a crucial role in the metabolism of steroids in the human body. It is responsible for converting certain steroids, such as testosterone and progesterone, into their corresponding 16-alpha-hydroxylated derivatives. This enzyme is primarily found in the liver and is involved in the biosynthesis of several important hormones, including cortisol, aldosterone, and androgens. It is also involved in the metabolism of certain drugs, such as oral contraceptives and anabolic steroids. Deficiency or dysfunction of steroid 16-alpha-hydroxylase can lead to a variety of medical conditions, including adrenal insufficiency, polycystic ovary syndrome, and certain forms of hypertension. In addition, mutations in the gene encoding this enzyme have been associated with certain inherited disorders, such as 16-alpha-hydroxylase deficiency and 11-beta-hydroxylase deficiency.

Octreotide is a synthetic hormone that is used in the medical field to treat various conditions related to the endocrine system. It is a somatostatin analog, which means that it is similar in structure to the natural hormone somatostatin, which is produced by the pancreas and other glands in the body. Octreotide is primarily used to treat acromegaly, a hormonal disorder that occurs when the pituitary gland produces too much growth hormone. It is also used to treat carcinoid tumors, which are tumors that produce excessive amounts of hormones, and to control diarrhea caused by certain medical conditions, such as inflammatory bowel disease or radiation therapy. Octreotide is usually administered as a subcutaneous injection, which means that it is injected just under the skin. It can also be administered as an intravenous infusion or as a nasal spray. The dosage and frequency of administration depend on the specific condition being treated and the individual patient's response to the medication.

Transcription factors are proteins that regulate gene expression by binding to specific DNA sequences and controlling the transcription of genetic information from DNA to RNA. They play a crucial role in the development and function of cells and tissues in the body. In the medical field, transcription factors are often studied as potential targets for the treatment of diseases such as cancer, where their activity is often dysregulated. For example, some transcription factors are overexpressed in certain types of cancer cells, and inhibiting their activity may help to slow or stop the growth of these cells. Transcription factors are also important in the development of stem cells, which have the ability to differentiate into a wide variety of cell types. By understanding how transcription factors regulate gene expression in stem cells, researchers may be able to develop new therapies for diseases such as diabetes and heart disease. Overall, transcription factors are a critical component of gene regulation and have important implications for the development and treatment of many diseases.

Lactation disorders refer to a range of conditions that can affect the production, quality, or flow of breast milk. These disorders can occur during pregnancy, during lactation, or after lactation has stopped. Some common lactation disorders include: 1. Insufficient milk production (lactation insufficiency): This occurs when a mother is not producing enough milk to meet the needs of her baby. It can be caused by a variety of factors, including stress, illness, or poor nutrition. 2. Milk supply problems: This refers to a range of issues that can affect the flow of milk, including plugged ducts, engorgement, and mastitis. 3. Breastfeeding difficulties: This can include problems with latching, positioning, or baby's sucking, which can make it difficult for the baby to get enough milk. 4. Breastfeeding pain: This can occur due to a variety of factors, including sore nipples, engorgement, or blocked milk ducts. 5. Breastfeeding cessation: This can occur due to a variety of factors, including the mother's decision to stop breastfeeding, difficulty breastfeeding, or medical reasons. Lactation disorders can have a significant impact on both the mother and the baby, and it is important to seek medical advice if you are experiencing any problems with breastfeeding.

Growth Hormone-Secreting Pituitary Adenoma, also known as acromegaly, is a rare hormonal disorder that occurs when the pituitary gland produces excessive amounts of growth hormone (GH). The pituitary gland is a small gland located at the base of the brain that produces hormones that regulate various bodily functions, including growth and development. In individuals with acromegaly, the excess GH causes the bones and soft tissues to grow abnormally, leading to a variety of physical and health problems. Common symptoms of acromegaly include enlargement of the hands and feet, thickening of the skin, joint pain, and excessive sweating. The condition can also lead to other health problems, such as diabetes, high blood pressure, and sleep apnea. Treatment for acromegaly typically involves surgery to remove the pituitary adenoma, followed by medication to control GH production. In some cases, radiation therapy may also be used to shrink the tumor. Early diagnosis and treatment are important to prevent complications and improve outcomes for individuals with acromegaly.

In the medical field, iodine isotopes refer to different forms of the element iodine that have different atomic weights due to the presence of different numbers of neutrons in their nuclei. The most commonly used iodine isotopes in medicine are iodine-123 (I-123) and iodine-131 (I-131). I-123 is a short-lived isotope with a half-life of 13.2 hours, which makes it useful for imaging the thyroid gland and other organs. It is often used in diagnostic procedures such as thyroid scans and radioiodine uptake tests. I-131, on the other hand, is a longer-lived isotope with a half-life of 8 days. It is commonly used in the treatment of thyroid cancer and hyperthyroidism. In these treatments, I-131 is administered to the patient, and it is taken up by the thyroid gland, where it emits beta particles that destroy the cancerous or overactive cells. Overall, iodine isotopes play an important role in medical imaging and treatment, particularly in the diagnosis and management of thyroid disorders.

Cloning, molecular, in the medical field refers to the process of creating identical copies of a specific DNA sequence or gene. This is achieved through a technique called polymerase chain reaction (PCR), which amplifies a specific DNA sequence to produce multiple copies of it. Molecular cloning is commonly used in medical research to study the function of specific genes, to create genetically modified organisms for therapeutic purposes, and to develop new drugs and treatments. It is also used in forensic science to identify individuals based on their DNA. In the context of human cloning, molecular cloning is used to create identical copies of a specific gene or DNA sequence from one individual and insert it into the genome of another individual. This technique has been used to create transgenic animals, but human cloning is currently illegal in many countries due to ethical concerns.

Analysis of Variance (ANOVA) is a statistical method used to compare the means of three or more groups. In the medical field, ANOVA can be used to compare the effectiveness of different treatments, interventions, or medications on a particular outcome or variable of interest. For example, a researcher may want to compare the effectiveness of three different medications for treating a particular disease. They could use ANOVA to compare the mean response (e.g., improvement in symptoms) between the three groups of patients who received each medication. If the results show a significant difference between the groups, it would suggest that one medication is more effective than the others. ANOVA can also be used to compare the means of different groups of patients based on a categorical variable, such as age, gender, or race. For example, a researcher may want to compare the mean blood pressure of patients in different age groups. They could use ANOVA to compare the mean blood pressure between the different age groups and determine if there are significant differences. Overall, ANOVA is a powerful statistical tool that can be used to compare the means of different groups in the medical field, helping researchers to identify which treatments or interventions are most effective and to better understand the factors that influence health outcomes.

In the medical field, binding sites refer to specific locations on the surface of a protein molecule where a ligand (a molecule that binds to the protein) can attach. These binding sites are often formed by a specific arrangement of amino acids within the protein, and they are critical for the protein's function. Binding sites can be found on a wide range of proteins, including enzymes, receptors, and transporters. When a ligand binds to a protein's binding site, it can cause a conformational change in the protein, which can alter its activity or function. For example, a hormone may bind to a receptor protein, triggering a signaling cascade that leads to a specific cellular response. Understanding the structure and function of binding sites is important in many areas of medicine, including drug discovery and development, as well as the study of diseases caused by mutations in proteins that affect their binding sites. By targeting specific binding sites on proteins, researchers can develop drugs that modulate protein activity and potentially treat a wide range of diseases.

Insulin-like Growth Factor Binding Protein 1 (IGFBP-1) is a protein that plays a crucial role in regulating the activity of insulin-like growth factors (IGFs), which are hormones that promote cell growth and division. IGFBP-1 binds to IGFs and modulates their activity, either by enhancing or inhibiting their effects on cells. In the medical field, IGFBP-1 is often studied in relation to various diseases and conditions, including cancer, diabetes, and cardiovascular disease. For example, IGFBP-1 has been shown to have anti-cancer properties, as it can inhibit the growth and proliferation of cancer cells. It has also been implicated in the development of type 2 diabetes, as levels of IGFBP-1 are often elevated in individuals with this condition. Additionally, IGFBP-1 has been linked to cardiovascular disease, as it can affect the function of the heart and blood vessels. Overall, IGFBP-1 is an important protein that plays a critical role in regulating cell growth and division, and its activity is closely tied to a number of important medical conditions.

Adenoma, Acidophil is a type of benign (non-cancerous) tumor that develops in the glands of the digestive system, particularly in the stomach. It is characterized by the presence of acid-secreting cells, which are responsible for producing hydrochloric acid in the stomach. Acidophilic adenomas are typically small and asymptomatic, meaning they do not cause any noticeable symptoms. However, in some cases, they can grow larger and cause problems such as stomach pain, nausea, vomiting, and difficulty swallowing. Treatment for acidophilic adenomas usually involves surgical removal, although in some cases, they may be monitored with regular endoscopy to ensure they do not grow or cause any complications.

Ethinyl estradiol is a synthetic estrogen hormone that is used in combination with progestin in birth control pills, patches, and vaginal rings. It is also used in hormone replacement therapy for menopausal symptoms and in the treatment of endometriosis and uterine fibroids. Ethinyl estradiol works by preventing ovulation and thickening the cervical mucus to prevent sperm from reaching the egg. It can also cause changes in the lining of the uterus to prevent implantation of a fertilized egg.

Cyclic AMP (cAMP) is a signaling molecule that plays a crucial role in many cellular processes, including metabolism, gene expression, and cell proliferation. It is synthesized from adenosine triphosphate (ATP) by the enzyme adenylyl cyclase, and its levels are regulated by various hormones and neurotransmitters. In the medical field, cAMP is often studied in the context of its role in regulating cellular signaling pathways. For example, cAMP is involved in the regulation of the immune system, where it helps to activate immune cells and promote inflammation. It is also involved in the regulation of the cardiovascular system, where it helps to regulate heart rate and blood pressure. In addition, cAMP is often used as a tool in research to study cellular signaling pathways. For example, it is commonly used to activate or inhibit specific signaling pathways in cells, allowing researchers to study the effects of these pathways on cellular function.

Castration is a surgical procedure that involves the removal of the testicles in males or the ovaries in females. In males, castration is often performed to treat conditions such as prostate cancer, testicular cancer, or advanced prostate enlargement. In females, castration is typically performed to treat conditions such as ovarian cancer or endometriosis. There are two main types of castration: surgical castration and chemical castration. Surgical castration involves the removal of the testicles or ovaries through surgery. Chemical castration involves the administration of drugs that suppress the production of hormones by the testicles or ovaries. Castration can have a number of effects on the body, including changes in hormone levels, sexual function, and mood. In males, castration can lead to a decrease in testosterone levels, which can cause changes in sexual desire, energy levels, and muscle mass. In females, castration can lead to a decrease in estrogen levels, which can cause changes in sexual desire, bone density, and mood.

DNA-binding proteins are a class of proteins that interact with DNA molecules to regulate gene expression. These proteins recognize specific DNA sequences and bind to them, thereby affecting the transcription of genes into messenger RNA (mRNA) and ultimately the production of proteins. DNA-binding proteins play a crucial role in many biological processes, including cell division, differentiation, and development. They can act as activators or repressors of gene expression, depending on the specific DNA sequence they bind to and the cellular context in which they are expressed. Examples of DNA-binding proteins include transcription factors, histones, and non-histone chromosomal proteins. Transcription factors are proteins that bind to specific DNA sequences and regulate the transcription of genes by recruiting RNA polymerase and other factors to the promoter region of a gene. Histones are proteins that package DNA into chromatin, and non-histone chromosomal proteins help to organize and regulate chromatin structure. DNA-binding proteins are important targets for drug discovery and development, as they play a central role in many diseases, including cancer, genetic disorders, and infectious diseases.

In the medical field, steroids refer to a class of drugs that are derived from the natural hormone cortisol, which is produced by the adrenal gland. Steroids are used to treat a wide range of medical conditions, including inflammatory diseases, autoimmune disorders, allergies, and certain types of cancer. There are two main types of steroids: corticosteroids and anabolic steroids. Corticosteroids are used to reduce inflammation and suppress the immune system, while anabolic steroids are used to build muscle mass and increase strength. Steroids can be administered in various forms, including oral tablets, injections, creams, and inhalers. They can have a range of side effects, including weight gain, mood changes, high blood pressure, and increased risk of infections. It is important to note that the use of steroids is closely monitored by healthcare professionals, and they are typically prescribed only for specific medical conditions and under the guidance of a doctor.。

Triiodothyronine, also known as T3, is a hormone produced by the thyroid gland that plays a crucial role in regulating metabolism in the body. Reverse T3, also known as rT3, is a form of T3 that is converted from T4 (thyroxine) in the liver and kidneys. It is not as biologically active as T3 and is often considered a waste product. In some cases, levels of rT3 may be elevated in the blood, which can indicate an underlying thyroid disorder or other health issue.

In the medical field, a peptide fragment refers to a short chain of amino acids that are derived from a larger peptide or protein molecule. Peptide fragments can be generated through various techniques, such as enzymatic digestion or chemical cleavage, and are often used in diagnostic and therapeutic applications. Peptide fragments can be used as biomarkers for various diseases, as they may be present in the body at elevated levels in response to specific conditions. For example, certain peptide fragments have been identified as potential biomarkers for cancer, neurodegenerative diseases, and cardiovascular disease. In addition, peptide fragments can be used as therapeutic agents themselves. For example, some peptide fragments have been shown to have anti-inflammatory or anti-cancer properties, and are being investigated as potential treatments for various diseases. Overall, peptide fragments play an important role in the medical field, both as diagnostic tools and as potential therapeutic agents.

Endocrine system diseases refer to disorders that affect the endocrine glands and the hormones they produce. The endocrine system is responsible for regulating various bodily functions, including growth and development, metabolism, and reproduction. Endocrine system diseases can be classified into two main categories: endocrine disorders and endocrine tumors. Endocrine disorders are conditions in which the endocrine glands produce too much or too little of a hormone, leading to imbalances in the body's chemical processes. Examples of endocrine disorders include diabetes, thyroid disorders, and Cushing's syndrome. Endocrine tumors, on the other hand, are abnormal growths of cells in the endocrine glands. These tumors can produce too much or too little of a hormone, leading to similar symptoms as endocrine disorders. Examples of endocrine tumors include pituitary adenomas, thyroid nodules, and adrenal gland tumors. Endocrine system diseases can have a significant impact on a person's quality of life and can lead to serious health complications if left untreated. Treatment options for endocrine system diseases depend on the specific condition and may include medication, surgery, or other therapies.

Anabolic agents are drugs that promote the growth and repair of tissues in the body, particularly muscle and bone. They are often used in the medical field to treat conditions such as muscle wasting, osteoporosis, and anemia. Anabolic agents work by increasing the production of proteins in the body, which are essential for building and repairing tissues. They are also sometimes used in sports to enhance muscle growth and performance. However, the use of anabolic agents for non-medical purposes is illegal and can have serious health risks.

Adenoma, Chromophobe is a type of benign (non-cancerous) tumor that develops in the adrenal gland. It is characterized by the absence of pigmentation, which is why it is called "chromophobe." Adenomas are usually small and grow slowly, and they are often discovered incidentally during imaging studies for other conditions. They can cause hormonal imbalances, such as high blood pressure or diabetes, if they produce excess hormones. Treatment for adenomas, chromophobe is usually surgical removal, although in some cases, medication may be used to control hormone production. The prognosis for people with adenomas, chromophobe is generally good, as they are not cancerous and do not spread to other parts of the body.

In the medical field, oligopeptides are short chains of amino acids that typically contain between two and 50 amino acids. They are often used in various medical applications due to their unique properties and potential therapeutic effects. One of the main benefits of oligopeptides is their ability to penetrate the skin and reach underlying tissues, making them useful in the development of topical treatments for a variety of conditions. For example, oligopeptides have been shown to improve skin elasticity, reduce the appearance of wrinkles, and promote the growth of new skin cells. Oligopeptides are also used in the development of medications for a variety of conditions, including osteoporosis, diabetes, and hypertension. They work by interacting with specific receptors in the body, which can help to regulate various physiological processes and improve overall health. Overall, oligopeptides are a promising area of research in the medical field, with potential applications in a wide range of therapeutic areas.

Hyperthyroidism is a medical condition in which the thyroid gland produces excessive amounts of thyroid hormones, specifically thyroxine (T4) and triiodothyronine (T3). This overproduction of hormones can cause an array of symptoms, including weight loss, increased heart rate, anxiety, irritability, tremors, and heat intolerance. Hyperthyroidism can be caused by a variety of factors, including Graves' disease, thyroiditis, and thyroid nodules. It can also be caused by taking too much thyroid hormone medication or by consuming excessive amounts of iodine. Treatment for hyperthyroidism typically involves medications to reduce the production of thyroid hormones, radioactive iodine therapy to destroy overactive thyroid cells, or surgery to remove part or all of the thyroid gland. The specific treatment approach depends on the underlying cause of the condition and the severity of the symptoms.

Hypogonadism is a medical condition characterized by a deficiency in the production of sex hormones, such as testosterone in males and estrogen and progesterone in females, by the gonads (ovaries in females and testes in males). This deficiency can result in a range of symptoms, including decreased libido, infertility, fatigue, weight gain, and osteoporosis. Hypogonadism can be primary, meaning that the gonads themselves are not functioning properly, or secondary, meaning that the hypothalamus or pituitary gland, which control the production of sex hormones, are not functioning properly. Causes of primary hypogonadism include genetic disorders, such as Klinefelter syndrome in males and Turner syndrome in females, as well as damage to the gonads due to injury, infection, or cancer treatment. Causes of secondary hypogonadism include pituitary tumors, chronic illnesses, and certain medications. Treatment for hypogonadism depends on the underlying cause and may include hormone replacement therapy, fertility treatments, or surgery.

Glucose is a simple sugar that is a primary source of energy for the body's cells. It is also known as blood sugar or dextrose and is produced by the liver and released into the bloodstream by the pancreas. In the medical field, glucose is often measured as part of routine blood tests to monitor blood sugar levels in people with diabetes or those at risk of developing diabetes. High levels of glucose in the blood, also known as hyperglycemia, can lead to a range of health problems, including heart disease, nerve damage, and kidney damage. On the other hand, low levels of glucose in the blood, also known as hypoglycemia, can cause symptoms such as weakness, dizziness, and confusion. In severe cases, it can lead to seizures or loss of consciousness. In addition to its role in energy metabolism, glucose is also used as a diagnostic tool in medical testing, such as in the measurement of blood glucose levels in newborns to detect neonatal hypoglycemia.

Glucocorticoids are a class of hormones produced by the adrenal gland that regulate glucose metabolism and have anti-inflammatory and immunosuppressive effects. They are commonly used in medicine to treat a variety of conditions, including: 1. Inflammatory diseases such as rheumatoid arthritis, lupus, and asthma 2. Autoimmune diseases such as multiple sclerosis and inflammatory bowel disease 3. Allergies and anaphylaxis 4. Skin conditions such as eczema and psoriasis 5. Cancer treatment to reduce inflammation and suppress the immune system 6. Endocrine disorders such as Cushing's syndrome and Addison's disease Glucocorticoids work by binding to specific receptors in cells throughout the body, leading to changes in gene expression and protein synthesis. They can also increase blood sugar levels by stimulating the liver to produce glucose and decreasing the body's sensitivity to insulin. Long-term use of high doses of glucocorticoids can have serious side effects, including weight gain, high blood pressure, osteoporosis, and increased risk of infection.

A prolactinoma is a benign (non-cancerous) tumor that develops in the pituitary gland, which is a small gland located at the base of the brain. The pituitary gland produces several hormones, including prolactin, which is responsible for stimulating milk production in the breasts of women who are breastfeeding or pregnant. Prolactinomas are the most common type of pituitary tumor, accounting for about 40% of all pituitary tumors. They are usually slow-growing and do not spread to other parts of the body. However, they can cause a variety of symptoms, depending on their size and location. The main symptom of a prolactinoma is an overproduction of prolactin, which can cause irregular menstrual periods, infertility, and breast milk production in women who are not pregnant or breastfeeding. In men, an overproduction of prolactin can cause erectile dysfunction, decreased libido, and infertility. Treatment for prolactinomas typically involves medication to lower prolactin levels and shrink the tumor. In some cases, surgery or radiation therapy may be necessary if the tumor is large or causing severe symptoms.

Thyroid Hormone Resistance Syndrome (THR) is a rare genetic disorder that affects the body's ability to respond to thyroid hormones. In individuals with THR, the thyroid hormones produced by the thyroid gland are not able to bind to the receptors in the body's cells, which means that the hormones are not able to stimulate the cells to function properly. This can lead to a variety of symptoms, including fatigue, weight gain, depression, and difficulty concentrating. THR is caused by mutations in genes that are involved in the production or function of thyroid hormone receptors. These mutations can be inherited from one or both parents, or they can occur spontaneously. There are several different types of THR, each of which is caused by a different mutation in a different gene. Diagnosis of THR typically involves a combination of blood tests to measure thyroid hormone levels and genetic testing to identify mutations in the relevant genes. Treatment for THR typically involves hormone replacement therapy with synthetic thyroid hormones, which can help to alleviate symptoms and improve overall health. However, the effectiveness of treatment can vary depending on the specific type of THR and the severity of the symptoms.

Receptors, Somatostatin are proteins found on the surface of cells that bind to the hormone somatostatin and trigger a response within the cell. Somatostatin is a hormone produced by the pancreas and the hypothalamus in the brain, and it plays a role in regulating various bodily functions, including growth, metabolism, and the digestive process. The receptors for somatostatin are found in many different tissues throughout the body, including the pancreas, the liver, the gallbladder, and the gastrointestinal tract. Activation of these receptors can lead to a variety of effects, including inhibition of cell growth and division, reduction of inflammation, and slowing of the digestive process.

In the medical field, weight gain refers to an increase in body weight over a period of time. It can be caused by a variety of factors, including changes in diet, lack of physical activity, hormonal imbalances, certain medications, and medical conditions such as hypothyroidism or polycystic ovary syndrome (PCOS). Weight gain can be measured in kilograms or pounds and is typically expressed as a percentage of body weight. A healthy weight gain is generally considered to be 0.5 to 1 kilogram (1 to 2 pounds) per week, while an excessive weight gain may be defined as more than 0.5 to 1 kilogram (1 to 2 pounds) per week over a period of several weeks or months. In some cases, weight gain may be a sign of a more serious medical condition, such as diabetes or heart disease. Therefore, it is important to monitor weight changes and consult with a healthcare provider if weight gain is a concern.

Prader-Willi Syndrome (PWS) is a genetic disorder that affects the development and growth of the body. It is caused by the loss of function of certain genes on chromosome 15, which leads to a variety of physical, behavioral, and cognitive symptoms. The symptoms of PWS can vary widely among affected individuals, but some common features include: * Excessive hunger and difficulty with weight control * Short stature * Intellectual disability * Delayed development of motor skills * Behavioral problems, such as aggression and self-injury * Hypotonia (low muscle tone) * Respiratory problems * Sleep apnea * Reproductive issues, such as infertility and delayed puberty PWS is usually diagnosed in early childhood, based on the presence of certain physical and behavioral symptoms. There is no cure for PWS, but treatment can help manage the symptoms and improve the quality of life for affected individuals. This may include a special diet to help control appetite and prevent obesity, physical therapy to improve motor skills, and behavioral therapy to address behavioral problems.

Calcium is a chemical element with the symbol Ca and atomic number 20. It is a vital mineral for the human body and is essential for many bodily functions, including bone health, muscle function, nerve transmission, and blood clotting. In the medical field, calcium is often used to diagnose and treat conditions related to calcium deficiency or excess. For example, low levels of calcium in the blood (hypocalcemia) can cause muscle cramps, numbness, and tingling, while high levels (hypercalcemia) can lead to kidney stones, bone loss, and other complications. Calcium supplements are often prescribed to people who are at risk of developing calcium deficiency, such as older adults, vegetarians, and people with certain medical conditions. However, it is important to note that excessive calcium intake can also be harmful, and it is important to follow recommended dosages and consult with a healthcare provider before taking any supplements.

Short bowel syndrome (SBS) is a medical condition that occurs when a significant portion of the small intestine is removed or damaged, leading to malabsorption of nutrients from food. The small intestine is responsible for absorbing most of the nutrients from food, including carbohydrates, proteins, fats, vitamins, and minerals. When a significant portion of the small intestine is lost, the body is unable to absorb enough nutrients to maintain normal bodily functions. SBS can be caused by a variety of factors, including surgical removal of the small intestine due to conditions such as cancer, inflammatory bowel disease, or trauma. It can also be caused by congenital abnormalities or infections that damage the small intestine. Symptoms of SBS can include diarrhea, abdominal pain, malnutrition, dehydration, and weight loss. Treatment for SBS typically involves dietary changes, such as a high-calorie, low-fiber diet, and the use of medications to manage symptoms and improve nutrient absorption. In severe cases, patients may require parenteral nutrition, which involves receiving nutrients directly into the bloodstream through a catheter.

Bromocriptine is a medication that is used to treat a variety of conditions, including Parkinson's disease, hyperprolactinemia (a condition in which the body produces too much of the hormone prolactin), and acromegaly (a hormonal disorder that causes the body to produce too much growth hormone). It is a dopamine agonist, which means that it works by mimicking the effects of dopamine, a neurotransmitter that is important for regulating movement, mood, and other bodily functions. Bromocriptine is usually taken by mouth, and it can be effective in reducing symptoms of Parkinson's disease and improving motor function in people with this condition. It can also be used to lower prolactin levels in people with hyperprolactinemia, and it may be used to treat acromegaly in some cases.

Insulin-like Growth Factor II (IGF-II) is a protein that plays a crucial role in the growth and development of various tissues in the human body. It is produced by the liver and other tissues, and its levels are regulated by the hormones insulin and growth hormone. IGF-II has several functions in the body, including promoting cell growth and differentiation, regulating metabolism, and modulating the immune response. It is also involved in the development of the fetal brain and skeletal system. In the medical field, IGF-II is often studied in relation to various diseases and conditions, including cancer, diabetes, and growth disorders. For example, high levels of IGF-II have been associated with an increased risk of certain types of cancer, while low levels may be associated with growth disorders such as dwarfism. Additionally, IGF-II has been used as a potential therapeutic target in the treatment of certain types of cancer.

Androgens are a group of hormones that are primarily responsible for the development and maintenance of male characteristics. They are produced by the testes in males and by the ovaries and adrenal glands in females. The most well-known androgen is testosterone, which is responsible for the development of male sexual characteristics such as facial hair, deep voice, and muscle mass. Other androgens include dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), and androstenedione. In addition to their role in sexual development, androgens also play a role in other bodily functions such as bone density, red blood cell production, and metabolism. They are also involved in the regulation of mood and behavior. Abnormal levels of androgens can lead to a variety of medical conditions, including androgen insensitivity syndrome, polycystic ovary syndrome (PCOS), and testicular feminization syndrome. Androgens are also used in medical treatment for conditions such as hypogonadism, breast cancer, and prostate cancer.

Receptors, Pituitary Hormone are proteins found on the surface of cells in the body that bind to specific hormones produced by the pituitary gland. These hormones include growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL). When these hormones bind to their respective receptors, they trigger a series of chemical reactions within the cell that ultimately lead to changes in cell function and behavior. For example, GH receptors stimulate growth and cell division, while TSH receptors stimulate the thyroid gland to produce thyroid hormones. Understanding the function and regulation of pituitary hormone receptors is important for understanding the normal functioning of the endocrine system and for diagnosing and treating disorders related to pituitary hormone imbalances.

Epinephrine, also known as adrenaline, is a hormone and neurotransmitter that plays a crucial role in the body's "fight or flight" response. It is produced by the adrenal glands and is released into the bloodstream in response to stress or danger. In the medical field, epinephrine is used as a medication to treat a variety of conditions, including anaphylaxis (a severe allergic reaction), cardiac arrest, and asthma. It works by constricting blood vessels, increasing heart rate and contractility, and relaxing smooth muscles in the bronchial tubes, which can help to open airways and improve breathing. Epinephrine is typically administered via injection, either intravenously or subcutaneously (under the skin). It is a powerful medication and should only be used under the guidance of a healthcare professional.

Blotting, Northern is a laboratory technique used to detect and quantify specific RNA molecules in a sample. It involves transferring RNA from a gel onto a membrane, which is then hybridized with a labeled complementary DNA probe. The probe binds to the specific RNA molecules on the membrane, allowing their detection and quantification through autoradiography or other imaging methods. Northern blotting is commonly used to study gene expression patterns in cells or tissues, and to compare the expression levels of different RNA molecules in different samples.

Proteins are complex biomolecules made up of amino acids that play a crucial role in many biological processes in the human body. In the medical field, proteins are studied extensively as they are involved in a wide range of functions, including: 1. Enzymes: Proteins that catalyze chemical reactions in the body, such as digestion, metabolism, and energy production. 2. Hormones: Proteins that regulate various bodily functions, such as growth, development, and reproduction. 3. Antibodies: Proteins that help the immune system recognize and neutralize foreign substances, such as viruses and bacteria. 4. Transport proteins: Proteins that facilitate the movement of molecules across cell membranes, such as oxygen and nutrients. 5. Structural proteins: Proteins that provide support and shape to cells and tissues, such as collagen and elastin. Protein abnormalities can lead to various medical conditions, such as genetic disorders, autoimmune diseases, and cancer. Therefore, understanding the structure and function of proteins is essential for developing effective treatments and therapies for these conditions.

Receptors, FSH (follicle-stimulating hormone) are proteins found on the surface of cells in the body that bind to and respond to the hormone follicle-stimulating hormone (FSH). FSH is produced by the anterior pituitary gland and plays a key role in regulating the menstrual cycle and male fertility. FSH receptors are found in the ovaries, testes, and other parts of the body, and they help to control the growth and development of follicles in the ovaries and the production of sperm in the testes. When FSH binds to its receptors, it triggers a series of chemical reactions within the cell that ultimately lead to the production of eggs or sperm.

Alpha-melanocyte-stimulating hormone (α-MSH) is a peptide hormone that is produced by the pituitary gland and the melanocytes (pigment-producing cells) in the skin. It plays a role in regulating the production of melanin, the pigment that gives skin its color, and also has effects on appetite, mood, and the immune system. α-MSH is a 13-amino acid peptide that is derived from the pro-opiomelanocortin (POMC) precursor protein. It is composed of two smaller peptides, α-MSH and β-MSH, which have different functions. α-MSH is the more potent of the two and is primarily responsible for its effects on melanin production and appetite regulation. In the medical field, α-MSH is sometimes used to treat conditions such as vitiligo, a skin disorder characterized by the loss of pigmentation, and anorexia nervosa, an eating disorder characterized by a lack of appetite and a distorted body image. It is also being studied for its potential use in the treatment of other conditions, such as depression and cancer.

Luteinizing Hormone, beta Subunit (LH beta) is a protein subunit that is a component of the luteinizing hormone (LH) molecule. LH is a hormone produced by the anterior pituitary gland that plays a key role in regulating the reproductive system in both males and females. In males, LH stimulates the production of testosterone by the Leydig cells of the testes. In females, LH triggers ovulation and stimulates the production of estrogen and progesterone by the ovaries. LH beta is one of two subunits that make up the LH molecule, the other being the alpha subunit. The beta subunit is responsible for binding to receptors on the target cells and initiating the signaling cascade that leads to the physiological effects of LH. LH beta is also used as a diagnostic marker in various medical conditions, such as polycystic ovary syndrome (PCOS), hypogonadism, and pituitary disorders.

In the medical field, "bone and bones" typically refers to the skeletal system, which is made up of bones, cartilage, ligaments, tendons, and other connective tissues. The skeletal system provides support and structure to the body, protects vital organs, and allows for movement through the use of muscles. Bones are the main component of the skeletal system and are responsible for providing support and protection to the body. There are 206 bones in the human body, which are classified into four types: long bones, short bones, flat bones, and irregular bones. Long bones, such as the femur and humerus, are cylindrical in shape and are found in the arms and legs. Short bones, such as the carpals and tarsals, are cube-shaped and are found in the wrists and ankles. Flat bones, such as the skull and ribs, are thin and flat and provide protection to vital organs. Irregular bones, such as the vertebrae and pelvis, have complex shapes that allow for specific functions. Overall, the bone and bones of the skeletal system play a crucial role in maintaining the health and function of the human body.

Leuprolide is a medication that is used to treat various conditions related to the endocrine system, particularly in men. It is a synthetic version of the hormone luteinizing hormone-releasing hormone (LHRH), which is produced by the hypothalamus and regulates the production of other hormones in the body. Leuprolide is commonly used to treat prostate cancer, uterine fibroids, and endometriosis. It works by blocking the production of testosterone, which can help slow the growth of prostate cancer cells and reduce the size of uterine fibroids. It can also be used to treat precocious puberty in children. Leuprolide is usually administered as an injection, either under the skin or into a muscle. The dosage and frequency of the injections will depend on the specific condition being treated and the individual patient's response to the medication. Common side effects of leuprolide include hot flashes, decreased sex drive, breast tenderness, and injection site reactions.

In the medical field, peptides are short chains of amino acids that are linked together by peptide bonds. They are typically composed of 2-50 amino acids and can be found in a variety of biological molecules, including hormones, neurotransmitters, and enzymes. Peptides play important roles in many physiological processes, including growth and development, immune function, and metabolism. They can also be used as therapeutic agents to treat a variety of medical conditions, such as diabetes, cancer, and cardiovascular disease. In the pharmaceutical industry, peptides are often synthesized using chemical methods and are used as drugs or as components of drugs. They can be administered orally, intravenously, or topically, depending on the specific peptide and the condition being treated.

Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal glands, which are located on top of the kidneys. It is a precursor to other hormones, including testosterone and estrogen, and plays a role in a variety of bodily functions. In the medical field, DHEA is often measured in blood or saliva tests to assess adrenal function and diagnose conditions such as adrenal insufficiency or Cushing's syndrome. It is also sometimes used as a supplement to treat conditions such as low testosterone levels, osteoporosis, and depression, although the evidence for its effectiveness is mixed and more research is needed. However, it is important to note that DHEA supplements can have potential side effects and may interact with other medications, so they should only be used under the guidance of a healthcare professional.

Receptors, Steroid are proteins found on the surface of cells that bind to and respond to steroid hormones, such as cortisol, estrogen, and testosterone. These hormones are important regulators of various physiological processes, including metabolism, growth and development, and immune function. When a steroid hormone binds to its receptor, it triggers a cascade of events within the cell that leads to changes in gene expression and ultimately alters the cell's behavior. Receptors, Steroid play a critical role in the body's response to hormones and are the target of many drugs used to treat conditions such as diabetes, cancer, and autoimmune diseases.

The adrenal glands are two small endocrine glands located on top of the kidneys in the human body. They are responsible for producing a variety of hormones that play important roles in regulating various bodily functions, including metabolism, blood pressure, and the stress response. The adrenal glands are composed of two main parts: the adrenal cortex and the adrenal medulla. The adrenal cortex produces hormones such as cortisol, aldosterone, and androgens, which help regulate metabolism, blood pressure, and the body's response to stress. The adrenal medulla, on the other hand, produces hormones such as adrenaline and noradrenaline, which help the body respond to stress by increasing heart rate, blood pressure, and breathing rate. In the medical field, the adrenal glands are often studied and monitored for a variety of conditions, including adrenal insufficiency, Cushing's syndrome, Addison's disease, and pheochromocytoma. These conditions can result from problems with the production or regulation of hormones by the adrenal glands, and can have a significant impact on a person's overall health and well-being.

Puberty, precocious refers to the early onset of puberty, which is defined as the onset of puberty before the age of 8 for girls and before the age of 9 for boys. Precocious puberty is a medical condition that can be caused by a variety of factors, including genetic predisposition, exposure to certain hormones or environmental factors, and certain medical conditions such as tumors or hormonal imbalances. The symptoms of precocious puberty may include the development of breast tissue in girls, the growth of pubic hair and underarm hair, and the onset of menstruation. In boys, precocious puberty may be indicated by the growth of pubic hair, the development of testicles, and an increase in muscle mass and height. Treatment for precocious puberty may involve the use of medications to suppress or delay puberty, as well as monitoring and management of any underlying medical conditions that may be contributing to the early onset of puberty. It is important to note that precocious puberty can have significant psychological and social impacts on affected individuals, and appropriate support and counseling may be necessary.

Blotting, Western is a laboratory technique used to detect specific proteins in a sample by transferring proteins from a gel to a membrane and then incubating the membrane with a specific antibody that binds to the protein of interest. The antibody is then detected using an enzyme or fluorescent label, which produces a visible signal that can be quantified. This technique is commonly used in molecular biology and biochemistry to study protein expression, localization, and function. It is also used in medical research to diagnose diseases and monitor treatment responses.

The cell nucleus is a membrane-bound organelle found in eukaryotic cells that contains the cell's genetic material, or DNA. It is typically located in the center of the cell and is surrounded by a double membrane called the nuclear envelope. The nucleus is responsible for regulating gene expression and controlling the cell's activities. It contains a dense, irregularly shaped mass of chromatin, which is made up of DNA and associated proteins. The nucleus also contains a small body called the nucleolus, which is responsible for producing ribosomes, the cellular structures that synthesize proteins.

Iodide Peroxidase (also known as Thyroid Peroxidase) is an enzyme that plays a critical role in the production of thyroid hormones in the thyroid gland. It catalyzes the oxidation of iodide ions to form iodine, which is then incorporated into thyroglobulin, a large protein produced by thyroid cells. The iodinated thyroglobulin is then broken down into smaller thyroid hormones, thyroxine (T4) and triiodothyronine (T3), which are essential for regulating metabolism in the body. In the medical field, the measurement of thyroid peroxidase antibodies (TPOAb) is often used as a diagnostic tool for autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease. In these conditions, the immune system mistakenly attacks the thyroid gland, leading to inflammation and damage to the gland's ability to produce thyroid hormones. The presence of TPOAb in the blood can indicate an autoimmune response and help guide treatment decisions.

Receptors, G-Protein-Coupled (GPCRs) are a large family of membrane proteins that play a crucial role in transmitting signals from the outside of a cell to the inside. They are found in almost all types of cells and are involved in a wide range of physiological processes, including sensory perception, neurotransmission, and hormone signaling. GPCRs are activated by a variety of molecules, including neurotransmitters, hormones, and sensory stimuli such as light, sound, and odor. When a molecule binds to a GPCR, it causes a conformational change in the protein that activates a G protein, a small molecule that acts as a molecular switch. The activated G protein then triggers a cascade of intracellular signaling events that ultimately lead to a cellular response. Because GPCRs are involved in so many different physiological processes, they are an important target for drug discovery. Many drugs, including those used to treat conditions such as hypertension, depression, and allergies, work by binding to specific GPCRs and modulating their activity.

Estrone (E1) is a naturally occurring estrogen hormone that is produced in the ovaries, adrenal glands, and placenta. It is one of the three major female sex hormones, along with estradiol and estriol. Estrone is responsible for a variety of physiological functions in the body, including the regulation of the menstrual cycle, the development of female secondary sexual characteristics, and the maintenance of bone density. It is also involved in the regulation of metabolism, cardiovascular function, and mood. Estrone is used in medical treatment for conditions such as menopause, osteoporosis, and breast cancer.

Breast neoplasms refer to abnormal growths or tumors in the breast tissue. These growths can be benign (non-cancerous) or malignant (cancerous). Benign breast neoplasms are usually not life-threatening, but they can cause discomfort or cosmetic concerns. Malignant breast neoplasms, on the other hand, can spread to other parts of the body and are considered a serious health threat. Some common types of breast neoplasms include fibroadenomas, ductal carcinoma in situ (DCIS), invasive ductal carcinoma, and invasive lobular carcinoma.

Arginine is an amino acid that plays a crucial role in various physiological processes in the human body. It is an essential amino acid, meaning that it cannot be synthesized by the body and must be obtained through the diet. In the medical field, arginine is used to treat a variety of conditions, including: 1. Erectile dysfunction: Arginine is a precursor to nitric oxide, which helps to relax blood vessels and improve blood flow to the penis, leading to improved sexual function. 2. Cardiovascular disease: Arginine has been shown to improve blood flow and reduce the risk of cardiovascular disease by lowering blood pressure and improving the function of the endothelium, the inner lining of blood vessels. 3. Wound healing: Arginine is involved in the production of collagen, a protein that is essential for wound healing. 4. Immune function: Arginine is involved in the production of antibodies and other immune system components, making it important for maintaining a healthy immune system. 5. Cancer: Arginine has been shown to have anti-cancer properties and may help to slow the growth of tumors. However, it is important to note that the use of arginine as a supplement is not without risks, and it is important to consult with a healthcare provider before taking any supplements.

In the medical field, "binding, competitive" refers to a type of interaction between a ligand (a molecule that binds to a receptor) and a receptor. Competitive binding occurs when two or more ligands can bind to the same receptor, but they do so in a way that limits the maximum amount of ligand that can bind to the receptor at any given time. In other words, when a ligand binds to a receptor, it competes with other ligands that may also be trying to bind to the same receptor. The binding of one ligand can prevent or reduce the binding of other ligands, depending on the relative affinities of the ligands for the receptor. Competitive binding is an important concept in pharmacology, as it helps to explain how drugs can interact with receptors in the body and how their effects can be influenced by other drugs or substances that may also be present. It is also important in the study of biological systems, where it can help to explain how molecules interact with each other in complex biological networks.

Receptors, estrogen are proteins found on the surface of cells in the body that bind to and respond to the hormone estrogen. Estrogen is a sex hormone that is primarily produced by the ovaries in women and by the testes in men. It plays a key role in the development and regulation of the female reproductive system, as well as in the development of secondary sexual characteristics in both men and women. Estrogen receptors are classified into two main types: estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). These receptors are found in a wide variety of tissues throughout the body, including the breast, uterus, bone, and brain. When estrogen binds to its receptors, it triggers a cascade of chemical reactions within the cell that can have a variety of effects, depending on the type of receptor and the tissue in which it is found. In the breast, for example, estrogen receptors play a role in the development and growth of breast tissue, as well as in the regulation of the menstrual cycle. In the uterus, estrogen receptors are involved in the thickening of the uterine lining in preparation for pregnancy. In the bone, estrogen receptors help to maintain bone density and prevent osteoporosis. In the brain, estrogen receptors are involved in a variety of functions, including mood regulation, memory, and learning. Abnormalities in estrogen receptor function or expression have been linked to a number of health conditions, including breast cancer, uterine cancer, osteoporosis, and mood disorders.

Receptors, Glucocorticoid are proteins found on the surface of cells in the body that bind to and respond to hormones called glucocorticoids. Glucocorticoids are a type of steroid hormone that are produced by the adrenal gland in response to stress or injury. They play a role in regulating a wide range of physiological processes, including metabolism, immune function, and inflammation. When glucocorticoid hormones bind to their receptors, they trigger a cascade of chemical reactions within the cell that leads to changes in gene expression and cellular function. This allows the body to respond to stress and maintain homeostasis.

Amino acids are organic compounds that are the building blocks of proteins. They are composed of an amino group (-NH2), a carboxyl group (-COOH), and a side chain (R group) that varies in size and structure. There are 20 different amino acids that are commonly found in proteins, each with a unique side chain that gives it distinct chemical and physical properties. In the medical field, amino acids are important for a variety of functions, including the synthesis of proteins, enzymes, and hormones. They are also involved in energy metabolism and the maintenance of healthy tissues. Deficiencies in certain amino acids can lead to a range of health problems, including muscle wasting, anemia, and neurological disorders. In some cases, amino acids may be prescribed as supplements to help treat these conditions or to support overall health and wellness.

Cell division is the process by which a single cell divides into two or more daughter cells. This process is essential for the growth, development, and repair of tissues in the body. There are two main types of cell division: mitosis and meiosis. Mitosis is the process by which somatic cells (non-reproductive cells) divide to produce two identical daughter cells with the same number of chromosomes as the parent cell. This process is essential for the growth and repair of tissues in the body. Meiosis, on the other hand, is the process by which germ cells (reproductive cells) divide to produce four genetically diverse daughter cells with half the number of chromosomes as the parent cell. This process is essential for sexual reproduction. Abnormalities in cell division can lead to a variety of medical conditions, including cancer. In cancer, cells divide uncontrollably and form tumors, which can invade nearby tissues and spread to other parts of the body.

In the medical field, "age factors" refer to the effects of aging on the body and its various systems. As people age, their bodies undergo a variety of changes that can impact their health and well-being. These changes can include: 1. Decreased immune function: As people age, their immune system becomes less effective at fighting off infections and diseases. 2. Changes in metabolism: Aging can cause changes in the way the body processes food and uses energy, which can lead to weight gain, insulin resistance, and other metabolic disorders. 3. Cardiovascular changes: Aging can lead to changes in the heart and blood vessels, including increased risk of heart disease, stroke, and high blood pressure. 4. Cognitive changes: Aging can affect memory, attention, and other cognitive functions, which can lead to conditions such as dementia and Alzheimer's disease. 5. Joint and bone changes: Aging can cause changes in the joints and bones, including decreased bone density and increased risk of osteoporosis and arthritis. 6. Skin changes: Aging can cause changes in the skin, including wrinkles, age spots, and decreased elasticity. 7. Hormonal changes: Aging can cause changes in hormone levels, including decreased estrogen in women and decreased testosterone in men, which can lead to a variety of health issues. Overall, age factors play a significant role in the development of many health conditions and can impact a person's quality of life. It is important for individuals to be aware of these changes and to take steps to maintain their health and well-being as they age.

Adrenal insufficiency is a medical condition in which the adrenal glands do not produce enough of certain hormones, specifically cortisol and aldosterone. The adrenal glands are small endocrine glands located on top of the kidneys, and they play a crucial role in regulating various bodily functions, including metabolism, blood pressure, and the stress response. There are two main types of adrenal insufficiency: primary and secondary. Primary adrenal insufficiency, also known as Addison's disease, is caused by damage to the adrenal glands themselves, usually due to an autoimmune response or an infection. Secondary adrenal insufficiency, on the other hand, is caused by a problem with the pituitary gland or hypothalamus, which are responsible for regulating the production of hormones by the adrenal glands. Symptoms of adrenal insufficiency can include fatigue, weakness, weight loss, low blood pressure, dizziness, and nausea. In severe cases, it can lead to shock and even death if not properly treated. Treatment typically involves hormone replacement therapy to replace the missing hormones, as well as addressing any underlying causes of the condition.

Thymus hormones are hormones produced by the thymus gland, a small organ located in the upper chest. The thymus gland plays a crucial role in the development and maturation of T-cells, a type of white blood cell that is essential for the immune system. There are several types of thymus hormones, including thymosin alpha-1, thymosin beta-4, and thymulin. These hormones are involved in various processes related to the immune system, including the proliferation and differentiation of T-cells, the regulation of immune responses, and the maintenance of immune homeostasis. Thymus hormones have been studied for their potential therapeutic applications in various medical conditions, including autoimmune diseases, cancer, and infectious diseases. However, more research is needed to fully understand the role of thymus hormones in the immune system and to develop effective treatments based on their activity.

In the medical field, "trans-activators" refer to proteins or molecules that activate the transcription of a gene, which is the process by which the information in a gene is used to produce a functional product, such as a protein. Trans-activators can bind to specific DNA sequences near a gene and recruit other proteins, such as RNA polymerase, to initiate transcription. They can also modify the chromatin structure around a gene to make it more accessible to transcription machinery. Trans-activators play important roles in regulating gene expression and are involved in many biological processes, including development, differentiation, and disease.

Cricetinae is a subfamily of rodents that includes hamsters, voles, and lemmings. These animals are typically small to medium-sized and have a broad, flat head and a short, thick body. They are found in a variety of habitats around the world, including grasslands, forests, and deserts. In the medical field, Cricetinae are often used as laboratory animals for research purposes, as they are easy to care for and breed, and have a relatively short lifespan. They are also used in studies of genetics, physiology, and behavior.

Inhibins are a group of hormones produced by the ovaries and testes in humans and other animals. They play a role in regulating the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland. Inhibins are primarily produced by the granulosa cells of the ovarian follicles and the Sertoli cells of the testes. Inhibins act as negative feedback regulators of FSH and LH production. When the levels of FSH and LH are high, inhibins are produced and released into the bloodstream, which then inhibits the production of FSH and LH by the pituitary gland. This feedback mechanism helps to maintain a balance between the production of FSH and LH and the development of ovarian follicles and sperm production. Inhibins are also involved in the regulation of pregnancy and lactation. During pregnancy, the levels of inhibins increase, which helps to suppress the production of FSH and LH, preventing the development of additional ovarian follicles and ovulation. In lactating women, inhibins help to suppress the production of FSH and LH, preventing the return of the menstrual cycle until after lactation has ended. Abnormal levels of inhibins can be associated with various medical conditions, including polycystic ovary syndrome (PCOS), premature ovarian failure, and testicular cancer.

Yttrium isotopes are radioactive forms of the element yttrium that are used in medical imaging and therapy. Yttrium-90 (90Y) is a commonly used isotope in targeted radionuclide therapy, where it is used to treat various types of cancer, including non-Hodgkin's lymphoma, liver cancer, and bone metastases. It is administered to the patient in the form of a radiopharmaceutical, which is a compound that contains the radioactive isotope and is designed to target specific cells or tissues in the body. The radiation emitted by the 90Y destroys the targeted cells, while minimizing damage to surrounding healthy tissue. Yttrium-88 (88Y) is another isotope that is used in medical imaging, specifically in positron emission tomography (PET) scans. It is used to study blood flow and metabolism in the body, and can be used to diagnose and monitor various conditions, including cancer, heart disease, and neurological disorders.

... known as growth hormone 1 (somatotropin; pituitary growth hormone) and growth hormone 2 (placental growth hormone; growth ... These cells release the peptides growth hormone-releasing hormone (GHRH or somatocrinin) and growth hormone-inhibiting hormone ... Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone ... whom have growth failure due to inadequate secretion of endogenous growth hormone (rHGH). Previously, the human growth hormone ...
... (GH2), also known more commonly as placental growth hormone (PGH) or growth hormone variant (GH-V), is a ... Its cogener is growth hormone 1 (GH1), or pituitary growth hormone. The protein encoded by this gene is a member of the ... "Entrez Gene: GH2 growth hormone 2". Handwerger S, Freemark M (2000). "The roles of placental growth hormone and placental ... 1980). "Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans". ...
... growth hormone in sports, and growth hormone for cows. Growth hormone deficiency is treated by replacing growth hormone. ... Growth hormone therapy refers to the use of growth hormone (GH) as a prescription medication-it is one form of hormone therapy ... Growth hormone is a peptide hormone secreted by the pituitary gland that stimulates growth and cell reproduction. In the past, ... growth hormone was extracted from human pituitary glands. Growth hormone is now produced by recombinant DNA technology and is ...
... and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver". Growth Hormone & IGF Research. 17 (2): 104 ... This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor ... "The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver". Growth Hormone & IGF Research. 9 (3): 212-8. ... Growth hormone receptor is a protein that in humans is encoded by the GHR gene. GHR orthologs have been identified in most ...
... , also known as pituitary growth hormone or simply as growth hormone (GH) somatotropin, is a protein that in ... "Entrez Gene: GH1 growth hormone 1". Binder G (2003). "Isolated growth hormone deficiency and the GH-1 gene: update 2002". Horm ... Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. Placental growth hormone ... Cattini PA, Yang X, Jin Y, Detillieux KA (2006). "Regulation of the human growth hormone gene family: possible role for Pit-1 ...
... and agonists of the growth hormone-releasing hormone receptor (GHRHR), such as growth hormone-releasing hormone (GHRH, ... of growth hormone (GH). They include agonists of the ghrelin/growth hormone secretagogue receptor (GHSR), such as ghrelin ( ... 2006). "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting ... Growth hormone secretagogues or GH secretagogues (GHSs) are a class of drugs which act as secretagogues (i.e., induce the ...
... (GHD), or human growth hormone deficiency, is a medical condition resulting from not enough growth ... Treatment is by growth hormone replacement using synthetic human growth hormone. The frequency of the condition is unclear. ... Children requiring treatment usually receive daily injections of growth hormone. Most pediatric endocrinologists monitor growth ... in which case it is known as combined pituitary hormone deficiency. Diagnosis involves blood tests to measure growth hormone ...
... (IGHD) is a rare congenital disorder characterized by growth hormone deficiency and ... Growth hormones, Endocrine-related cutaneous conditions, Growth disorders, Pituitary disorders). ... Jurado, Pérez; Argente, J. (1994). "Molecular Basis of Familial Growth Hormone Deficiency". Hormone Research. 42 (4-5): 189-197 ... postnatal growth failure. It is divided into four subtypes that vary in terms of cause and clinical presentation. They include ...
... (GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth ... The growth hormone secretagogue receptor may also be linked to learning and memory. First of all, the receptor is found in the ... growth+hormone+secretagogue+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Ghrelin at ... Building on this, it was found that there are growth hormone secretagogue receptors in the VTA and that ghrelin acts on the VTA ...
"Growth hormone replacement therapy increases handgrip strength in 21 growth hormone-deficient adults". Growth Hormone & IGF ... Growth hormones in sports refers to the use of growth hormones (GH or HGH) for athletic enhancement, as opposed to growth ... Biogenesis scandal Growth hormone treatment HGH controversies Lionel Messi "Human Growth Hormone/Steroids Statutory Overview". ... Human growth hormone occurs naturally in the human body where it functions by stimulating growth of essentially all tissues, ...
Peptide hormones, Hormones of the somatotropic axis, Neuroendocrinology, Human hormones, Growth hormone secretagogues, Growth ... Endogenous: somatocrinin somatoliberin growth hormone-releasing hormone (GHRH or GH-RH; HGNC symbol is GHRH) growth hormone- ... where it stimulates growth hormone (GH) secretion by stimulating the growth hormone-releasing hormone receptor. GHRH is ... Growth hormone is required for normal postnatal growth, bone growth, regulatory effects on protein, carbohydrate, and lipid ...
Assays estimate that growth hormone and growth hormone binding protein form a natural complex at a 1:1 ratio for transport and ... Growth hormone-binding protein (GHBP) is a soluble carrier protein for growth hormone (GH). The full range of functions of GHBP ... Baumann G (1999). "Growth Hormone Binding Proteins". In Bengtsson B (ed.). Growth Hormone. Endocrine Updates. Vol. 4. Springer ... Edens A, Southard JN, Talamantes F (Dec 1994). "Mouse growth hormone-binding protein and growth hormone receptor transcripts ...
The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing ... Gaylinn BD (Apr 1999). "Molecular and cell biology of the growth hormone-releasing hormone receptor". Growth Hormone & IGF ... GHRHR is distinct from the growth hormone secretagogue receptor (also known as the ghrelin receptor), where growth hormone ... encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release ...
... is a very rare genetic disorder which is characterized ... "Dwarfism, low-birth-weight type with unresponsiveness to growth hormone , Genetic and Rare Diseases Information Center (GARD ... "OMIM Entry - 223500 - DWARFISM, LOW-BIRTH-WEIGHT TYPE, WITH UNRESPONSIVENESS TO GROWTH HORMONE". omim.org. Retrieved 2022-06-12 ... "Dwarfism Low-Birth-Weight Type with Unresponsiveness to Growth Hormone symptoms & causes". FDNA Telehealth. Retrieved 2022-06- ...
"Evidence and interpretation". Human growth hormone (somatropin) in adults with growth hormone deficiency. National Institute ... in adults with growth hormone deficiency by normative reference limits: Data of the German KIMS cohort". Growth Hormone & IGF ... The score of the QoL-AGHDA is used to determine the extent to which growth hormone deficiency has affected the patient's ... The QoL-AGHDA addresses seven different areas of concern for growth hormone deficient (GHD) patients. They are: body image and ...
... use of growth hormones. No concrete evidence linking premature puberty to growth hormones was found, in part because no samples ... as opposed to growth hormone, the specific peptide hormone produced in the brain. In 1993, FDA approved the use of bovine ... all animal growth-promoting hormones allowed in the US were sex hormones (steroids and analogues that target the same receptor ... The use of growth hormones was particularly common in the U.K., where beef production was heavily industrialized.) This had ...
This hormone stimulates growth hormone release. Amylin controls glucose homeostasis and gastric motility Glucose-dependent ... The gastrointestinal hormones (or gut hormones) constitute a group of hormones secreted by enteroendocrine cells in the stomach ... Ghrelin is a peptide hormone released from the stomach and liver and is often referred to as the "hunger hormone" since high ... The gastrointestinal hormones can be divided into three main groups based upon their chemical structure. Gastrin- ...
By influencing the hormones, the cells' growth can be changed along with its function. These hormones can cause cancer to not ... "e.hormone , Endocrine System : Types of Hormones". e.hormone.tulane.edu. Retrieved 2017-04-06. "The Endocrine System". classes. ... hormone receptors Glucagon receptors Gonadotropin receptors Gonadotropin-releasing hormone receptors Growth hormone receptors ... and peptide hormones composed of polypeptides, e.g. thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing ...
Most insect species contain only juvenile growth hormone (JH) III. To date JH 0, JH I, and JH II have been identified only in ... Insect growth regulator Neoteny Riddiford, L. M. (1994). "Cellular and molecular actions of juvenile hormone I. General ... Watt, G. R.; Davey, K. G. (1996). "Cellular and Molecular Actions of Juvenile Hormone. II. Roles of Juvenile Hormone in Adult ... JH is principally degraded by the enzymes juvenile-hormone esterase (JHE) or juvenile hormone epoxide hydrolase (JHEH). JHE and ...
Trophic hormones are hormones of the anterior lobe of the pituitary. These hormones affect growth, function, or nutrition of ... Endocrine system Tropic hormone Non-tropic hormone Look up trophic hormone in Wiktionary, the free dictionary. v t e (Articles ... The gut contains peptides that stimulate mucosal growth of stomach, colon, and small bowl cells. The hormones secreted control ... Trophic hormones from the anterior pituitary include: Thyroid-stimulating hormone (TSH or thyrotropin) - stimulates the thyroid ...
Sex hormones play an important role in bone growth and maintenance. The effects of hormone therapy on bone health are not fully ... Feminizing hormone therapy, also known as transfeminine hormone therapy, is hormone therapy and sex reassignment therapy to ... The effects of hormone therapy on bone health are reversible should treatment be interrupted. However, withdrawing hormone ... Changes in mood and well-being occur with hormone therapy in transgender women. Side effects of hormone therapy have the ...
These hormones are prolactin, growth hormone, TSH, adrenocorticotropic hormone, FSH and LH. They are all released by anterior ... Growth hormone releasing hormone (GHRH): stimulates GH secretion · Somatostatin: inhibits GH (and other hormone) secretion · ... Hormones of the hypothalamus, Hormones of the pituitary gland, Hormones of the hypothalamus-pituitary axis). ... Hypothalamic-pituitary hormones are hormones that are produced by the hypothalamus and pituitary gland. Although the organs in ...
Holmes SJ, Shalet SM (1996). "Role of growth hormone and sex steroids in achieving and maintaining normal bone mass". Horm. Res ... A steroid hormone is a steroid that acts as a hormone. Steroid hormones can be grouped into two classes: corticosteroids ( ... Steroid hormones are generally carried in the blood, bound to specific carrier proteins such as sex hormone-binding globulin or ... The first identified mechanisms of steroid hormone action were the genomic effects. In this pathway, the free hormones first ...
These hormones act very similarly to animal steroidal hormones by promoting growth and development. In plants these steroidal ... Plant cells produce hormones that affect even different regions of the cell producing the hormone. Hormones are transported ... Plant hormones frequently regulate the concentrations of other plant hormones. Plants also move hormones around the plant ... Plants need hormones at very specific times during plant growth and at specific locations. They also need to disengage the ...
A hormone-sensitive cancer, or hormone-dependent cancer, is a type of cancer that is dependent on a hormone for growth and/or ... A hormone-sensitive cancer, or hormone-dependent cancer, is a type of cancer that is dependent on a hormone for growth and/or ... As the growth of hormone dependent cancer is driven by sex hormones, surgical removal of the organs that synthesizes the sex ... The main types of Hormone-sensitive cancers are the following. Breast cancer is often hormone responsive, since growth or ...
... and growth hormone. These counterregulatory hormones-the term is usually used in the plural-raise the level of glucose in the ... and growth hormone. The rise in blood concentrations of these counterregulatory hormones is dependent upon both exercise ... A counterregulatory hormone is a hormone that opposes the action of another. The action of insulin is counterregulated by ... In healthy people, counterregulatory hormones constitute a principal defense against hypoglycemia, and levels are expected to ...
Some hormones, such as insulin and growth hormones, can be released into the bloodstream already fully active. Other hormones, ... Storage and secretion of the hormone. Transport of the hormone to the target cell(s). Recognition of the hormone by an ... Hormone secretion can be stimulated and inhibited by: Other hormones (stimulating- or releasing -hormones) Plasma ... "Hormones". MedlinePlus. U.S. National Library of Medicine. "Hormone - The hormones of plants". Encyclopedia Britannica. ...
The hypothalamus uses growth hormone-releasing hormone (GHRH or somatoliberin) to tell the pituitary to release somatotropin. ... Releasing hormones and inhibiting hormones are hormones whose main purpose is to control the release of other hormones, either ... The main releasing hormones are as follows: The hypothalamus uses thyrotropin-releasing hormone (TRH or thyroliberin) to tell ... The main release-inhibiting hormones or inhibiting hormones are as follows: The hypothalamus uses somatostatin to tell the ...
It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and ... The change at puberty is triggered by growth hormone, and its pulsatility differs in boys and girls.[clarification needed] In ... SHBG inhibits the function of these hormones. Thus, the local bioavailability of sex hormones is influenced by the level of ... Selva DM, Hammond GL (July 2009). "Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver ...
Growth hormone deficiency. Some children simply don't produce enough growth hormone, including those born with a poorly ... It can also be due to one or more of many abnormal conditions, such as chronic (prolonged) growth hormone or thyroid hormone ... About half of them do not have growth hormone deficiency, and consequently benefited very little, if at all, from the hormone ... Limiting sales of the hormone to children diagnosed with growth hormone deficiency, rather than being short for any reason, ...
Isolated growth hormone deficiency is a condition caused by a severe shortage or absence of growth hormone. Explore symptoms, ... Isolated growth hormone deficiency is a condition caused by a severe shortage or absence of growth hormone. Growth hormone is a ... to a molecule called growth hormone releasing hormone. The binding of growth hormone releasing hormone to the receptor triggers ... Growth hormone is produced in the pituitary gland. and plays a major role in promoting the bodys growth. Growth hormone also ...
... is the effector of growth induced by growth hormone (GH). IGF-I deficiency can be the result of GH resistance or insensitivity ... Growth Hormone Deficiency in Children, Growth Failure in Children, Growth Hormone Deficiency FAQs, and Growth Hormone ... Insulin-like growth factor I (IGF-I) is the effector of growth induced by growth hormone (GH). IGF-I deficiency can be the ... encoded search term (Growth Hormone Resistance) and Growth Hormone Resistance What to Read Next on Medscape ...
... a consistent exercise and sleep schedule will help promote healthy hormone release. ... Although theres no single magical exercise to promote the most human growth hormone, ... Exercise and Human Growth Hormone HGH is the primary hormone your body uses for growth and cell reproduction. Levels are ... Harvard Health Publishing: Growth hormone, athletic performance, and aging * Growth Hormone & IGF Research: Acute resistance ...
HIF-1 that has been known to induce tumour growth. ... A hormone that controls sleep and hunger also activates a ... Sleep, Hunger Controlling Hormone Associated With Cancer Growth Personalised Printable Document (PDF). Please complete this ... Sleep, Hunger Controlling Hormone Associated With Cancer Growth. .article-author__avatar{float:left;}.article-author__avatar ... Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors account for about 2.4% of ...
Read growth hormone deficiency FAQs, information including the symptoms in children such as: short height for age, increased ... Growth hormone deficiency can be treated with growth hormone replacement therapy. A drug called somatropin or growth hormone ( ... Growth hormone deficiency can occur at any age. Growth hormone is necessary for normal growth and development in children. In ... constitutional growth delay).. Although growth hormone was originally used to treat growth hormone deficiency (this group of ...
Knowing that growth hormone fluctuates throughout the day, blood tests can be somewhat meaningless when trying to get an ... What is Growth Hormone. Growth Hormone (aka somatotropin) is released into the blood stream from the anterior pituitary gland. ... Benefits of Growth Hormone. Knowing that growth hormone fluctuates throughout the day, blood tests can be somewhat meaningless ... Anyways, thats injectable synthetic growth hormone, not really the growth hormone that Ill be writing about below. ...
FTC Targets Bogus Anti-Aging Claims for Pills and Sprays Promising Human Growth Hormone Benefits. Settlement Provides Up To $20 ... human growth hormone (HGH) levels and provide anti-aging benefits, including weight loss and increased cognitive function. In ... HGH is a hormone released by the pituitary gland that plays a role in human development. The new FTC brochure, entitled "HGH ... and the sublingual sprays Master HGH and Super HGH promise that these products will significantly increase growth hormone ...
... Pituitary growth ... The growth hormone does this through a direct action mediated through growth hormone receptors on target cells and through an ... One of the most popular sources of growth hormone in the market is Anabolic Research Pituitary Growth Hormone, which is ... The growth hormone therefore has both direct and indirect actions on muscles but with overall enlargement and strength. ...
A mouse with targeted ablation of the growth hormone-releasing hormone gene: a new model of isolated growth hormone deficiency ... Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev. Biol. 229:141-162. View this article ... Growth hormone (GH) is a pleiotropic hormone synthesized and secreted by the pituitary (15, 16). The pattern of GH secretion is ... and activated partial thromboplastin time during replacement therapy with human recombinant growth hormone in growth hormone ...
Marketers of Bogus Growth Hormone Sprays Settle with FTC www.consumerlab.com/recalls/10131/marketers-of-bogus-growth-hormone- ... Marketers of Bogus Growth Hormone Sprays Settle with FTC. On May 29, 2007 the Federal Trade Commission (FTC)announced that two ... containing or causing the body to produce human growth hormone (HGH). The FTC also accused one company and owner of sending ...
... idiopathic growth hormone deficiency and idiopathic or gestational short sta ... recombinant human growth hormone is used in the pediatric population to treat short stature due to growth hormone deficiency ( ... idiopathic growth hormone deficiency and idiopathic or gestational short stature) treated with recombinant human growth hormone ... This hormone can stimulate tissue growth, linear growth (height), and protein, carbohydrate, lipid, and mineral metabolism. It ...
... is the effector of growth induced by growth hormone (GH). IGF-I deficiency can be the result of GH resistance or insensitivity ... Growth Hormone Deficiency in Children, Growth Failure in Children, Growth Hormone Deficiency FAQs, and Growth Hormone ... Insulin-like growth factor I (IGF-I) is the effector of growth induced by growth hormone (GH). IGF-I deficiency can be the ... encoded search term (Growth Hormone Resistance) and Growth Hormone Resistance What to Read Next on Medscape ...
Adrenals and a Review of Other Hormones Including Thyroid and Growth Hormone. Posted by AutismOne On August 15, 2012, 4:41 am ...
Leias Answer: Dear Shelby, HGH or human growth hormone, also called somatotropin,. is an endocrine hormone secreted by the ... human growth hormone is such a large molecule, it cannot be taken and absorbed orally, but must be given via injections. in ... Leia: I am very curious about HGH, human growth hormone therapy. As I understand it, it is best. to take a homeopathic remedy ... Human Growth Hormone Research. Therefore, ongoing research is being made into other ways to increase the HGH levels more ...
Iatrogenic Creutzfeldt-Jakob Disease from Commercial Cadaveric Human Growth Hormone Brian S. Appleby. , Mei Lu, Alberto Bizzi, ... Iatrogenic Creutzfeldt-Jakob Disease from Commercial Cadaveric Human Growth Hormone. ...
While previous studies showed that exercise can increase growth hormones ... its secretion of growth hormones and the stimulants to which it responds. ... as well as release of growth hormones.. About Ghrelin, the Gut-Secreted Growth Hormones. According to studies about ghrelin, ... Important Facts to Learn from Studies about Growth Hormones. Evelina Ely July 21, 2022 0 Comments ...
... suspect that intensive exercise can slow down aging because exercise increases the production of growth hormone. If this is ... Growth hormone repairs joints, skin and other connective tissues. Some endocrinologists ... More noticeable was the effect on adrenaline and especially growth hormone levels. The total amount of adrenaline and growth ... Growth hormone repairs joints, skin and other connective tissues. Some endocrinologists suspect that intensive exercise can ...
"Human Growth Hormone" by people in this website by year, and whether "Human Growth Hormone" was a major or minor topic of these ... Human Growth and Growth Hormone: From Antiquity to the Recominant Age to the Future. Front Endocrinol (Lausanne). 2021; 12: ... Growth and Growth Hormone through the Ages: Art and Science. Horm Res Paediatr. 2022; 95(6):515-528. ... Efficacy of growth hormone therapy in Kearns-Sayre syndrome: the KIGS experience. J Pediatr Endocrinol Metab. 2016 Nov 01; 29( ...
Growth Hormone Deficiency in Children - Learn about the causes, symptoms, diagnosis & treatment from the Merck Manuals - ... Symptoms of Growth Hormone Deficiency Symptoms of growth hormone deficiency depend on various factors such as the childs age ... Growth hormone deficiency is the most common pituitary hormone deficiency and is accompanied by poor overall growth and short ... Hormones are chemical messengers that affect the activity of another part of the body. Growth hormone regulates growth and ...
Normal anterior pituitary gland tissue is present in specimen 5. About 80% of the tumor cells are positive for growth hormone ... Conclusion: Features consistent with a pituitary microadenoma, in this clinical setting presumably a growth hormone secreting ... In skeletally mature individuals, a growth hormone secreting adenoma results in acromegaly. In the skeletally immature, in whom ... "growth-hormone-pituitary-microadenoma-gigantism","modality":"X-ray","series":[{"id":10001000,"content_type":"image/jpeg"," ...
Growth Hormone and Diabetes Mellitus, Diabetes, Volume 14, Issue 1, 1 January 1965, Pages 43-45, https://doi.org/10.2337/diab. ... Growth Hormone and Diabetes Mellitus Ernest Greenberg, M.D Ernest Greenberg, M.D ... Ernest Greenberg; Growth Hormone and Diabetes Mellitus. Diabetes 1 January 1965; 14 (1): 43-45. https://doi.org/10.2337/diab. ...
Top 3 Natural Human Growth Hormone Boosters in Pills GenF20 Plus Pills And Spray Reviews 2023 Male Extra Review - Is It A ... At a certain point in a mans life, he starts producing less testosterone and human growth hormone, leading to male menopause. ... Provacyl Review - Natural Human Growth Hormone Booster. Provacyl Pills: Ingredients, Side Effects, User Reviews 2021. If you ... Amino Acids Which Stimulate Growth Hormone. Provacyl contains essential amino acids like L-Glutamine, GABA or Gamma- ...
A placebo-controlled, dose-ranging study of a growth hormone releasing factor in HIV-infected patients with abdominal fat ... We therefore assessed the effect of TH9507, a growth hormone releasing factor (GRF) analog on abdominal fat accumulation and ... Recent studies also suggest that growth hormone levels are reduced in HIV-infected patients, and correlate inversely with ... Objective: To investigate the effects of TH9507, a novel growth hormone releasing factor, on abdominal fat accumulation, ...
Exercise capacity and hormonal response in adults with childhood onset growth hormone deficiency during long-term somatropin ... Growth hormone (GH) deficiency in adults in associated with reduced muscular strength and peak oxygen uptake (peak Vo2). How ... Exercise capacity and hormonal response in adults with childhood onset growth hormone deficiency during long-term somatropin ... Publication date & source: 1998-10, Growth Horm IGF Res., 8(5):377-84.. Publication type: Clinical Trial; Multicenter Study; ...
6 more authors) (2022) A. thaliana hybrids develop growth abnormalities through integration of stress, hormone and growth ... A. thaliana hybrids develop growth abnormalities through integration of stress, hormone and growth signalling ... demonstrate that a combination of natural alleles of OAK regulates growth and development through the integration of hormone ... The involvement of stress and hormone signalling in outgrowth formation was supported by a global transcriptome analysis, which ...
Adult, Cross-Over Studies, Double-Blind Method, Female, Growth Hormone/deficiency, Health Status, Humans, Male, Mental Health, ... Quality of life in adults with growth hormone (GH) deficiency : response to treatment with recombinant human GH in a placebo- ... Growth Hormone/deficiency; Health Status; Humans; Male; Mental Health; Middle Aged; Placebos; Quality of Life; Recombinant ... Quality of life in adults with growth hormone (GH) deficiency : response to treatment with recombinant human GH in a placebo- ...
N2 - The functional significance of growth hormone (GH) receptor (GHR) internalization is unknown; therefore, we have analyzed ... AB - The functional significance of growth hormone (GH) receptor (GHR) internalization is unknown; therefore, we have analyzed ... Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization ... Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization ...
The plasma growth hormone response to intravenous insulin was compared with that of oral clonidine in a multicentre trial in 64 ... Either test was judged to give a positive result if the maximum plasma growth hormone concentration was at least 20 mU/1. In 42 ... It is concluded that clonidine and insulin have similar reliability as test of growth hormone secretion, but that clonidine may ... Comparison of the intravenous insulin and oral clonidine tolerance tests for growth hormone secretion. The Health Services ...
Hormone Releasing Peptide TB-500 Medicine Grade Bodybuilding For Muscle Recover with Certificate form Quality Growth Hormone ... 2mg/Vial Growth Hormone Releasing Peptide TB-500 Medicine Grade Bodybuilding For Muscle Recover Growth Hormone Releasing ... GHRP-6 Growth Hormone Releasing Peptide Muscle Growth White Frozen Powder Ghrp-6/G6 ... Human Growth Hormone 98% Purity GHRP-6 Bodybuilding Injection Peptide And Muscle Growth ...
Learn about the veterinary topic of Use of Growth Hormone in Animals. Find specific details on this topic and related topics ... Growth hormone improves growth and feed efficiency in sheep but not in poultry. Recombinant GH in pigs has dramatic effects, ... The peptide most commonly used to enhance growth and production is growth hormone (GH). Its chemical structure is species- ... Growth hormone has been approved for commercial use in some countries to increase milk production output and efficiency. ...
  • Isolated growth hormone deficiency is a condition caused by a severe shortage or absence of growth hormone. (medlineplus.gov)
  • Because they do not have enough of this hormone, people with isolated growth hormone deficiency commonly experience a failure to grow at the expected rate and have unusually short stature. (medlineplus.gov)
  • There are four types of isolated growth hormone deficiency differentiated by the severity of the condition, the gene involved, and the inheritance pattern. (medlineplus.gov)
  • Isolated growth hormone deficiency type IA is caused by an absence of growth hormone and is the most severe of all the types. (medlineplus.gov)
  • People with isolated growth hormone deficiency type IB produce very low levels of growth hormone. (medlineplus.gov)
  • Individuals with isolated growth hormone deficiency type II have very low levels of growth hormone and short stature that varies in severity. (medlineplus.gov)
  • The incidence of isolated growth hormone deficiency is estimated to be 1 in 4,000 to 10,000 individuals worldwide. (medlineplus.gov)
  • Isolated growth hormone deficiency is caused by mutations in one of at least three genes. (medlineplus.gov)
  • Isolated growth hormone deficiency types IA and II are caused by mutations in the GH1 gene. (medlineplus.gov)
  • Without sufficient growth hormone, the body fails to grow at its normal rate, resulting in slow growth and short stature as seen in isolated growth hormone deficiency types IA, IB, and II. (medlineplus.gov)
  • Decreased growth hormone activity due to GHRHR gene mutations is responsible for many cases of isolated growth hormone deficiency type IB. (medlineplus.gov)
  • It is unknown how mutations in the BTK gene contribute to short stature in people with isolated growth hormone deficiency type III. (medlineplus.gov)
  • When Do Symptoms of Non-acquired isolated growth hormone deficiency Begin? (nih.gov)
  • Isolated growth hormone deficiency is estimated to occur in 1/4,000 to 1/10,000 children. (msdmanuals.com)
  • This study aims at assessing how recombinant human growth hormone treatment of children and young people suffering from isolated growth hormone deficiency affects some selected parameters of the immune system: a percentage of lymphocytes, granulocytes, monocytes, concentrations of A, G, and M immunoglobulins, a percentage of T lymphocytes divided into subpopulations CD4 and CD8, a percentage of NK and B lymphocytes, and phagocytic activity of granulocytes and monocytes. (nel.edu)
  • The study comprised 30 children and young people aged 4.2-18 years with isolated growth hormone deficiency both prior to and 6 months after rhGH (recombinant human growth hormone) treatment with a dose of 0.093 IU/kg every 24 hr. (nel.edu)
  • rhGH treatment of patients with isolated growth hormone deficiency can have positive influence on the phagocytic activity of scavenger cells, mainly granulocytes, which in children with isolated growth hormone deficiency seems to be lower than in their health peers. (nel.edu)
  • Growth hormone treatment of children with isolated growth hormone deficiency does not significantly affect the activity of the immune system expressed by the phagocytic activity of monocytes, the percentage of B, T and NK lymphocytes and IgG concentration in blood serum. (nel.edu)
  • If the child does not produce enough growth hormone after this stimulation, then the child is diagnosed with growth hormone deficiency. (healthychildren.org)
  • Patients diagnosed with growth hormone deficiency should undergo an MRI of the head to exclude a brain tumor (eg, craniopharyngioma). (medscape.com)
  • The human form of growth hormone, also called somatotropin , is made by the pituitary gland. (cancer.org)
  • Growth hormone is one of several hormones made by the pituitary gland, which is located at the base of the brain behind the nose. (healthychildren.org)
  • The FDA's recent approval of growth hormone (GH) therapy for idiopathic short stature (ISS) has led to some controversy. (medscape.com)
  • Third, with the approval of GH for idiopathic short stature, pediatricians will have many opportunities to discuss this issue with parents who request hormone therapy. (medscape.com)
  • As a result, type IB is characterized by short stature, but this growth failure is typically not as severe as in type IA. (medlineplus.gov)
  • Evaluation of a child with short stature and slow growth pattern may include a bone age x-ray (x-ray of the left wrist and hand) and various screening laboratory tests. (healthychildren.org)
  • Because people with this condition don't have enough of this hormone, they have short stature, which is noticeable from early childhood. (nih.gov)
  • Growth hormone deficiency typically results in abnormally slow growth and short stature. (msdmanuals.com)
  • Thyroxine and thyroid-stimulating hormone: Hypothyroidism should be excluded as a cause of growth failure and short stature. (medscape.com)
  • Many European paintings, particularly those of the Spanish Court, portray people with extremely short stature who may have had growth hormone deficiency (GHD). (medscape.com)
  • Ghrelin and growth hormone secretagogues (GHS): modulation of growth hormone secretion and therapeutic applications]. (nih.gov)
  • A condition of reduced function of the anterior pituitary gland characterized by decreased secretion of one or more of the pituitary hormones growth hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, prolactin, luteinizing hormone, and follicle-stimulating hormone. (nih.gov)
  • Growth hormone secretion is highest during deep sleep, so getting enough restful sleep can support healthy levels. (genesishealthinstitute.com)
  • Growth hormone deficiency (GHD), defined as suboptimal GH secretion, includes a group of different etiologic disorders. (bmj.com)
  • Hypopituitarism can be primary (a pituitary disorder) or secondary to interference with hypothalamic secretion of specific releasing hormones that control anterior pituitary hormone (GH, FSH, LH, ACTH, TSH) production. (msdmanuals.com)
  • The treatment for growth hormone deficiency is administration of recombinant human growth hormone by subcutaneous injection (under the skin) once a day. (healthychildren.org)
  • Effects of recombinant human growth hormone (rhGH) replacement therapy on detailed immunologic parameters in somatotropine--deficient paediatrics patients prior and after 6 months of rhGH treatment. (nel.edu)
  • Szynaka W, Petriczko L, Grabarek E, Miklaszewicz N, Domagala E, Walczak I, Effects of recombinant human growth hormone (rhGH) replacement therapy on detailed immunologic parameters in somatotropine--deficient paediatrics patients prior and after 6 months of rhGH treatment. (nel.edu)
  • Deficiency of growth hormone receptor is treated by the administration of recombinant human IGF - 1 or Insulin-like growth factor - 1. (healthhearty.com)
  • Growth hormone usually results in an increase in height for growth hormone-deficient individuals, as long as the growth plates have not fused. (healthychildren.org)
  • The reason for the growth hormone deficiency should be understood, and it is important to recheck for growth hormone deficiency when the child is an adult, because some children no longer test as if they are growth hormone deficient when they are fully grown. (healthychildren.org)
  • This patient was evaluated for growth failure at 7 years of age and was found to be growth hormone deficient. (cdc.gov)
  • CTP-modified human GH (MOD-4023) has been developed for once-weekly administration in growth hormone-deficient (GHD) adults and children. (endocrine-abstracts.org)
  • Then our local doctors will review your results to determine if you are deficient in either he Human Growth Hormone or the Testosterone hormone. (hgh1.com)
  • What happens when the body is deficient of growth hormone receptors that are responsible for growth and development of the body? (healthhearty.com)
  • Reports of rapidly progressive and fatal degenerative neurologic disorders in three recipients of human growth hormone (hGH) have been received by the U.S. Food and Drug Administration (FDA) and the National Institutes of Health (NIH). (cdc.gov)
  • The committee was instituted to follow up recipients of human growth hormone derived from pituitary glands that was distributed by NIH under and IND. (nih.gov)
  • Bovine growth hormone (BGH), also known as bovine somatotropin (BST) is the natural form of this hormone in cattle. (cancer.org)
  • Recombinant bovine growth hormone (rBGH) or recombinant bovine somatotropin (rBST) refers to bovine growth hormone that is made in a lab using genetic technology. (cancer.org)
  • Acromegaly is a rare syndrome resulting from the excessive production of the growth hormone somatotropin by tumors in the anterior pituitary gland of adult cats. (petmd.com)
  • The hypersecretion of the growth hormone somatotropin by an anterior pituitary tumor. (petmd.com)
  • Recombinant bovine growth hormone (rBGH) is a synthetic (man-made) hormone that is marketed to dairy farmers to increase milk production in cows. (cancer.org)
  • What is recombinant bovine growth hormone (rBGH)? (cancer.org)
  • Bovine growth hormone levels are not significantly higher in milk from rBGH-treated cows. (cancer.org)
  • Another look at bovine growth hormone. (nih.gov)
  • Finally, studies on the development and potential use of hormone/growth factor analogs, agonists, or antagonists with potential clinical utility to modify prostate growth and tumor development and/or progression will be encouraged. (nih.gov)
  • Treatment usually involves specific hormone replacement and removal of any causative tumor. (msdmanuals.com)
  • endocrinopathies result when the tumor produces hormones or destroys hormone-producing tissue. (msdmanuals.com)
  • The physiology of human growth: a review. (medscape.com)
  • The Human Growth Foundation (HGF) is a nonprofit organization concerned with children's growth disorders and adult growth hormone deficiency. (nih.gov)
  • Ankiel, the feel-good story in baseball this year after getting himself on the good side of earned runs (seven last night alone), ordered a 12-month supply of human growth hormone in 2004, according to an exclusive in today's New York Daily News . (sportsfilter.com)
  • It has to be a human growth deficiency and it is scientifically provable. (sportsfilter.com)
  • The recombinant HGH in IsotropinTM HGH PRO 6X is made from natural, non-animal elements and is an exact replica of the Growth Hormone produced in the human body. (vitanatural.net)
  • It works by increasing the natural production of human growth hormone (HGH), which can help fight signs of aging and improve your quality of life. (genesishealthinstitute.com)
  • What is Human Growth Hormone (HGH)? (genesishealthinstitute.com)
  • Human Growth Hormone (HGH), also known as growth hormone (GH), is like your body's repair and maintenance crew. (genesishealthinstitute.com)
  • Findings from the new study were published recently in PLOS ONE through an article titled "Fibroblast growth factor23 is associated with axonal integrity and neural network architecture in the human frontal lobes. (medicilon.com)
  • The Food and Drug Administration approved Protropin, human growth hormone made using genetically modified bacteria, for therapeutic use in 1985. (nih.gov)
  • Two of the earliest products to reach the market were human insulin, used to treat diabetes, and human growth hormone, used in children with pituitary gland disorders. (nih.gov)
  • In the United States, human-derived growth hormone was produced and distributed by the National Institute of Health's (NIH's) National Pituitary Agency. (medscape.com)
  • What does HGH (human growth hormone or Somatropin) do? (supplement4fitness.com)
  • Genotropin PFIZER - 12mg (36IU) generic name - growth hormone - somatropin Genotropin is an injectable drug representing a synthetic human growt. (supplement4fitness.com)
  • Humano Trope ANHUI ANKE 10mg - 30 I.U. generic name - human growth hormone - HGH Humano Trope is a synthetically formulated HGH (Human Growth Ho. (supplement4fitness.com)
  • Norditropin NOVO NORDISK - 1x 30 I.U. generic name - human growth hormone - HGH Norditropin is a synthetically formulated HGH (Human Growth. (supplement4fitness.com)
  • Men and women over age thirty are turning to Kingsberg Medical as their Bay Area choice for San Francisco human growth hormone therapy. (hght.com)
  • San Francisco human growth hormone therapy is available right here in the Bay Area to men and women. (hght.com)
  • What Is Human Growth Hormone Therapy, and Who Needs It? (hght.com)
  • Any adult over age thirty who has symptoms associated with diagnosed GHD can benefit from San Francisco human growth hormone therapy. (hght.com)
  • HGH doctors in San Francisco CA prescribe bioidentical human growth hormone to supplement low GH levels. (hght.com)
  • San Francisco human growth hormone therapy reverses the symptoms associated with growth hormone deficiency in adults. (hght.com)
  • The same applies to other local doctors who provide San Francisco human growth hormone therapy. (hght.com)
  • With our Human Growth Hormone Clinics located in every city in the United States, we can help you to experience the energy and great looks that you once had when you were years younger. (hgh1.com)
  • Our expert clinical advisors and licensed doctors who work in our local HGH Clinics are all the most knowledgeable professionals out there because we will only work with the best staff and brand named high quality Human Growth Hormone and Testosterone medications on the market. (hgh1.com)
  • To reach out to our Human Growth Hormone Clinics , all you need to do is to pick up the phone and call our toll free phone number which is located on the top of this page. (hgh1.com)
  • From there, our local doctor can determine which hormone is causing your issues, write your prescription and send it directly from our Human Growth Hormone Clinics to our pharmacy where you will be shipped the most high quality medication right to your home or office. (hgh1.com)
  • Our extremely convenient local Human Growth Hormone Clinics work only with the most professional and knowledgeable expert clinical advisors and licensed doctors. (hgh1.com)
  • Growth and metabolism of the human body is regulated by a hormone secreted by the anterior pituitary gland. (healthhearty.com)
  • The diagnosis of growth hormone deficiency cannot be made on a single random growth hormone level, because growth hormone is secreted in pulses. (healthychildren.org)
  • In September 1966, a diagnosis of growth hormone deficiency was made. (cdc.gov)
  • Diagnosis involves measurement of pituitary hormone levels and CT or MRI to detect structural pituitary anomalies or brain tumors. (msdmanuals.com)
  • Birth weight and length: Intrauterine growth retardation is an issue in the differential diagnosis and should be apparent from the birth history. (medscape.com)
  • The couple may have had growth hormone deficiency, although such a diagnosis was not recognized until the early 1900s. (medscape.com)
  • The length of growth hormone treatment depends on how well the child's height responds to growth hormone injections and how puberty affects the growth . (healthychildren.org)
  • Endocrine reassessment should be undertaken after completion of growth and puberty, because some patients will require long-term GH therapy into adulthood because of its other beneficial effects. (bmj.com)
  • The current practice is a subcutaneous injection of growth hormone and daily administration is now commonly used. (medscape.com)
  • Rosenbloom AL, Guevara-Aguirre J, Rosenfeld RG, Francke U. Growth hormone receptor deficiency in Ecuador. (medscape.com)
  • Kranzler JH, Rosenbloom AL, Martinez V, Guevara-Aguirre J. Normal intelligence with severe insulin-like growth factor I deficiency due to growth hormone receptor deficiency: a controlled study in a genetically homogeneous population. (medscape.com)
  • IGF-I deficiency can be the result of GH resistance or insensitivity due to genetic disorders of the GH receptor causing GH receptor deficiency (growth hormone receptor deficiency [GHRD], Laron syndrome) or postreceptor defects, including the principal transduction agent STAT5b, the IGF-I/IGFBP3 stabilizer acid labile subunit (ALS), the IGF-I gene, or the IGF-I receptor. (medscape.com)
  • If the test results are positive, the doctor will immediately start the treatment so that receptor deficiency does not hamper the growth, development and metabolic activity of the person. (healthhearty.com)
  • The hormone used to treat these patients was produced and distributed by the National Hormone and Pituitary Program (NHPP, formerly the National Pituitary Agency) under an investigational exemption for the use of a new drug (IND). (cdc.gov)
  • Growth hormone is a protein that is necessary for the normal growth of the body's bones and tissues. (medlineplus.gov)
  • and plays a major role in promoting the body's growth. (medlineplus.gov)
  • HGH therapy is the treatment of growth hormone deficiency (GHD), a condition that occurs when the pituitary gland no longer provides enough of the hormone for the body's needs. (hght.com)
  • Recombinant insulin growth factor I in growth therapy. (medscape.com)
  • The foundation also sponsors adult and pediatric Internet discussion forums to support the exchange of information about growth hormone deficiency and growth hormone replacement therapy. (nih.gov)
  • Growth Hormone Stimulating Peptide Therapy can help you feel younger and healthier. (genesishealthinstitute.com)
  • This therapy can be used alongside testosterone therapy or hormone replacement therapy. (genesishealthinstitute.com)
  • That's where Growth Hormone Stimulating Peptide Therapy comes in. (genesishealthinstitute.com)
  • Objective: Growth hormone (GH) replacement therapy currently requires daily injections. (endocrine-abstracts.org)
  • Response to growth hormone therapy is measured (every 3-6 mo) by sequential height determinations and by occasional bone age determinations. (medscape.com)
  • With years of experience in the field of hormone replacement therapy (HRT), our board-certified doctors and professional medical staff are here to help you restore homeostasis to your life through hormonal balance. (hght.com)
  • At our HGH treatment center, San Francisco adults discover a better way to get hormone replacement therapy. (hght.com)
  • Our Hormone Replacement Therapy program is extremely simple, easy and convenient to do. (hgh1.com)
  • We work online and over the phone with you during the entire Hormone Replacement Therapy program. (hgh1.com)
  • The GH1 gene provides instructions for making the growth hormone protein. (medlineplus.gov)
  • The GHRHR gene provides instructions for making a protein called the growth hormone releasing hormone receptor. (medlineplus.gov)
  • Primary acid-labile subunit deficiency due to recessive IGFALS mutations results in postnatal growth deficit associated with low circulating insulin growth factor (IGF)-I, IGF binding protein-3 levels, and hyperinsulinemia. (medscape.com)
  • The excessive levels of somatomedin C, however, promote protein synthesis and growth in a variety of tissues such as the bone cartilage, soft tissues, especially in the head and neck region. (petmd.com)
  • The most critical of these proteins is the signal transducer and activator of transcription 5b (STAT5b), which couples GH binding to the activation of gene expression that leads to the intracellular effects of GH, including synthesis of IGF-I, insulin-like growth factor binding protein 3 (IGFBP3), and ALS. (medscape.com)
  • A powerful blend of HGH, IGF-1, Growth Factors and 28 other ingredients designed to increase uptake of oxygen and the production of ATP, to improve protein synthesis and support the generation of connective tissue. (vitanatural.net)
  • Adequate protein intake is especially important as it provides the necessary building blocks for growth hormone synthesis. (genesishealthinstitute.com)
  • Ribbon diagrams are a graphic tool that helps researchers to visualize protein structures such as growth hormone. (nih.gov)
  • Growth Hormone Support may also enhance healthy muscle protein synthesis, muscle recovery and lean muscle mass for athletes. (wishmarketmd.com)
  • The growth hormone receptor is a protein with a number of cytokine receptors and a prolactin receptor, and belongs to transmembrane proteins. (healthhearty.com)
  • A soluble form, known as the growth hormone binding protein that corresponds to extracellular domain of full length receptor. (healthhearty.com)
  • There are many causes of growth hormone deficiency, most of which are present at birth (called ' congenital ') but may take several years to become apparent or it can develop later (called 'acquired') . (healthychildren.org)
  • In both instances, growth hormone deficiency may be acquired or congenital (including hereditary genetic causes). (msdmanuals.com)
  • Congenital causes include abnormalities of the GH-releasing hormone receptor and of the GH1 gene and certain central nervous system (CNS) malformations. (msdmanuals.com)
  • What is the best training program to improve testosterone and growth hormone? (mikemahler.com)
  • Fixating on training to optimize testosterone and growth hormone is likely going to lead to a disappointing outcome. (mikemahler.com)
  • Yes, testosterone and growth hormone can go up from an intense strength training session. (mikemahler.com)
  • Nevertheless, an increase in both testosterone and growth hormone is a positive indicator of a productive training session and a much more desirable effect than an increase in cortisol. (mikemahler.com)
  • To get the most out of intense training you want to go into each session with optimal testosterone and growth hormone levels, especially testosterone. (mikemahler.com)
  • Testosterone is the ultimate motivational hormone. (mikemahler.com)
  • You produce an abundance of testosterone and growth hormone when you get into a deep sleep state and the longer you're in that state the better. (mikemahler.com)
  • In addition to improving testosterone and growth hormone production, deep sleep lowers cortisol and adrenaline production so you're less likely to store stubborn body fat. (mikemahler.com)
  • May be isolated (IGHD) or combined with other anterior and/or posterior pituitary hormone deficiencies (CPHD). (bmj.com)
  • Growth hormone is released into the bloodstream from the anterior pituitary gland. (yourhormones.info)
  • Current published guidelines recommend the evaluation of adult GHD to be based on clinical findings, medical history, and using the appropriate GH stimulation test for biochemical confirmation [ 7 - 9 ], with the exception of patients with three or more pituitary hormone deficiencies and low serum IGF-I levels [ 10 ]. (hindawi.com)
  • Associated pituitary hormone deficiencies require treatment with hormone replacement and can evolve over time. (bmj.com)
  • In order for growth hormone replacement to be effective, other pituitary deficiencies should be treated. (medscape.com)
  • Radiation of the spine, either prophylactic or therapeutic, may further impair the growth potential of the vertebrae and further jeopardize height gain. (msdmanuals.com)
  • MAGIC (Major Aspects of Growth in Children) Foundation is a national, nonprofit organization that provides support and education about growth disorders in children and growth hormone deficiency in adults. (nih.gov)
  • Deficiency of growth hormone results in growth-related disorders. (healthhearty.com)
  • In adults, excessive growth hormone for a long period of time produces a condition known as acromegaly, in which patients have swelling of the hands and feet and altered facial features. (yourhormones.info)
  • Growth hormone deficiency (GHD) in adults is characterized by alterations in body composition, carbohydrate and lipid metabolism, bone mineral density, cardiovascular risk profile, and quality of life [ 1 ]. (hindawi.com)
  • Growth hormone (GH) also has effects on bone mineral density, body composition, metabolic profile, and quality of life. (bmj.com)
  • It is now clear that growth hormone contributes to both bone mass and muscle mass reaching the best possible level, as well as reducing fat mass during development to an adult. (yourhormones.info)
  • The specialist is therefore likely to discuss the benefits of continuing growth hormone after growth has completed until age 25 to make sure bone and muscle mass reach the best possible level. (yourhormones.info)
  • HGH improves growth of muscle tissue and helps to regulate body composition, body fluids, muscle and bone growth, sugar and fat metabolism, and possibly heart function. (supplement4fitness.com)
  • Growth factors may emerge as an interesting alternative in the reconstruction of tissues, highlighting the growth hormone (GH), a regulator of bone growth and remodeling, which plays a key role affecting chondrocytes, osteoclasts, and osteoblasts. (bvsalud.org)
  • Improper functioning of receptors may result in Laron syndrome, characterized by dwarfism, delayed bone growth, and insensitivity towards administered growth hormone. (healthhearty.com)
  • Usually, the child is on growth hormone injections until growth is complete, which is sometimes many years. (healthychildren.org)
  • The main treatment is to replace the growth hormone using injections - either once a day or several times a week. (yourhormones.info)
  • Growth hormone deficiency (GHD) is a well-recognized clinical syndrome in adults. (hindawi.com)
  • In adults, it does not cause growth but it helps to maintain normal body structure and metabolism , including helping to keep blood glucose levels within set levels. (yourhormones.info)
  • Growth hormone deficiency may also develop in adults due to brain injury, a pituitary tumour or damage to the pituitary gland (for example, after brain surgery or radiotherapy for cancer treatment). (yourhormones.info)
  • There is evidence that 30-50% of adults with growth hormone deficiency feel tired to a level that impairs their wellbeing. (yourhormones.info)
  • These adults may benefit from lifelong treatment with growth hormone. (yourhormones.info)
  • What are the symptoms of growth hormone deficiency in adults? (hght.com)
  • Second, the risk for insulin resistance in older children who were SGA suggests caution in the use of GH to promote growth in these children. (medscape.com)
  • Both the natural and recombinant forms of the hormone stimulate a cow's milk production by increasing levels of another hormone known as insulin-like growth factor (IGF-1). (cancer.org)
  • Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. (medscape.com)
  • Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation. (medscape.com)
  • Bonapace G, Concolino D, Formicola S, Strisciuglio P. A novel mutation in a patient with insulin-like growth factor 1(IGF1) deficiency. (medscape.com)
  • Partial primary deficiency of insulin-like growth factor (IGF)-I activity associated with IGF1 mutation demonstrates its critical role in growth and brain development. (medscape.com)
  • Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene. (medscape.com)
  • Total absence of functional acid labile subunit, resulting in severe insulin-like growth factor deficiency and moderate growth failure. (medscape.com)
  • Some pediatric endocrinologists diagnose growth hormone deficiency based on an extremely low level of insulin-like growth factor 1 (IGF-1), which varies much less in the course of the day than growth hormone. (healthychildren.org)
  • The anabolic effects, meanwhile, are mediated by somatomedin C (insulin-like growth factor I), which is secreted by the liver in response to growth hormone stimulation. (petmd.com)
  • Insulin-like growth factor I (IGF-I) is the effector of growth induced by growth hormone (GH). (medscape.com)
  • Secondary end points included triglyceride levels, the ratio of total cholesterol to high-density lipoprotein (HDL) cholesterol, the level of insulin-like growth factor I (IGF-I), and self-assessed body image. (nih.gov)
  • Growth hormone release is lowered in pregnancy and if the brain senses high levels of growth hormone or insulin-like growth factors already in the blood. (yourhormones.info)
  • Growth hormone response to insulin is the most reliable test for growth hormone deficiency. (medscape.com)
  • The pituitary gland is located at the base of the brain and produces many hormones, including growth hormone. (medlineplus.gov)
  • The pituitary gland also produces other hormones that have different functions from growth hormone. (yourhormones.info)
  • First, does drinking milk from rBGH-treated cows increase blood levels of growth hormone or IGF-1 in consumers? (cancer.org)
  • Of greater concern is the fact that milk from rBGH-treated cows has higher levels of IGF-1, a hormone that normally helps some types of cells to grow. (cancer.org)
  • IGF- 1 levels are dependent on the amount of growth hormone in the blood but can also be low in normal, young children, so the test must be interpreted carefully. (healthychildren.org)
  • The treatment starts with higher doses more frequently and then adjusts as the patient's growth hormone levels reach the ideal level. (genesishealthinstitute.com)
  • Individuals with adult growth hormone deficiency (AGHD) often report increased rates of anxiety and depression due to the negative physical effects of insufficient HGH levels. (genesishealthinstitute.com)
  • As growth hormone levels naturally decline, several strategies can be employed to keep energy levels and promote their increase. (genesishealthinstitute.com)
  • Chronic stress can negatively impact growth hormone levels. (genesishealthinstitute.com)
  • Growth hormone levels are increased by sleep, stress, exercise and low glucose levels in the blood. (yourhormones.info)
  • Very rarely, increased growth hormone levels can occur in children before they reach their final height, which can lead to excessive growth of long bones, resulting in the child being abnormally tall. (yourhormones.info)
  • Additionally, growth hormone has been linked to a sensation of wellbeing, specifically energy levels. (yourhormones.info)
  • The new study showed that high levels of fibroblast growth factor 23 (FGF23) were associated with structural changes in the brain's frontal lobes. (medicilon.com)
  • With critical hormone levels decreasing significantly or being depleted by the time many people enter their fifties, sixties, and seventies, the need is greater than ever for action. (hght.com)
  • Sometimes a person with sufficient levels of the hormone in the body may also show retarded growth, due to the deficiency of growth hormone receptors. (healthhearty.com)
  • This results in increased levels of hormone in the plasma as it is not utilized in the body. (healthhearty.com)
  • Doctors keep a check on growth and development, blood glucose levels, and development of adverse effects due to IGF - 1. (healthhearty.com)
  • Several clinical studies have shown that the inclusion of the GABA stimulates Growth hormone. (vitanatural.net)
  • This release is controlled by two other hormones that are released from the hypothalamus (a part of the brain): growth hormone-releasing hormone, which stimulates the pituitary to release growth hormone, and somatostatin, which inhibits that release. (yourhormones.info)
  • This receptor attaches (binds) to a molecule called growth hormone releasing hormone. (medlineplus.gov)
  • These receptors are responsible for triggering several cellular responses when the hormone binds to them. (healthhearty.com)
  • Its activation occurs when the growth hormone binds to it. (healthhearty.com)
  • Type II - The growth hormone binds properly to the cell surface however, there are problems related to its processing. (healthhearty.com)
  • Eventually these abnormalities in joint cartilage growth and metabolism alter normal joint biomechanics, which can lead to degenerative joint disease. (petmd.com)
  • A more accurate but still imperfect way to diagnose growth hormone deficiency is a growth hormone stimulation test. (healthychildren.org)
  • However, growth hormone stimulation tests can over diagnose growth hormone deficiency. (healthychildren.org)
  • Growth hormone stimulation tests vary and are complicated, so they are usually performed under the guidance of a pediatric endocrinologist. (healthychildren.org)
  • All three patients had had growth failure secondary to growth hormone deficiency. (cdc.gov)
  • Approximately 15% of patients with growth hormone deficiency have an abnormality of the pituitary gland (eg, ectopic bright spot, empty or small sella). (medscape.com)
  • Growth hormone secretagogues: mechanism of action and use in aging. (nih.gov)
  • It is fully automated and can be readily reconfigured to produce virtually any approved or experimental vaccine, hormone, replacement enzyme, antibody, or other biopharmaceutical. (nih.gov)
  • IGF-I mutations and heterozygous IGF-I receptor mutations are distinguished by their causing intrauterine growth retardation. (medscape.com)
  • IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. (medscape.com)
  • The HGF offers a brochure about adult growth hormone deficiency. (nih.gov)
  • Update of guidelines for the use of growth hormone in children: The Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. (medscape.com)
  • Growth hormone also plays a role in various chemical reactions (metabolic processes) in the body. (medlineplus.gov)
  • A number of trials have shown that children who were SGA with postnatal growth restriction benefit from GH. (medscape.com)
  • Mutations in the GH1 gene prevent or impair the production of growth hormone. (medlineplus.gov)
  • Mutations in the GHRHR gene impair the production or release of growth hormone. (medlineplus.gov)
  • Studies are also invited that will examine the patterns of gene expression in the prostate in vivo or in prostate cells in response to hormone or growth factor action. (nih.gov)
  • Type I - This type is characterized by defect in growth hormone receptor gene, preventing the binding of growth hormone to its receptor. (healthhearty.com)
  • Children with growth hormone deficiency are usually much shorter than their peers (that is, well below the 3 rd percentile line ) and over time, they tend to drop farther and farther below the normal range. (healthychildren.org)
  • In general, there are few children who experience side effects from growth hormone. (healthychildren.org)
  • Growth hormone deficiency (GHD) in children is a rare but treatable cause of growth failure in children. (bmj.com)
  • Growth hormone deficiency is the most common pituitary hormone deficiency in children and can be isolated or accompanied by deficiency of other pituitary hormones. (msdmanuals.com)
  • Growth hormone acts on many parts of the body to promote growth in children. (yourhormones.info)
  • Too little growth hormone (deficiency) results in poor growth in children. (yourhormones.info)
  • A growth chart depicts the child's growth over time, allows comparison of the height or weight to other children, and graphically depicts changes in growth or growth velocity. (medscape.com)
  • In the 1950s, growth hormone isolated from the pituitaries of humans and anthropoid apes was discovered to stimulate growth in children who had growth hormone deficiency. (medscape.com)
  • From 1958-1985, a limited supply of this cadaver-derived pituitary growth hormone was used to treat 8000 children who had growth hormone deficiency in the United States. (medscape.com)
  • Moreover, since there are some studies that indicate that environmental factors also increase the risk for development of prostate cancer, an additional focus will be on studies that will explore the role of environmental factor(s) in affecting hormonal/growth factor action in prostate. (nih.gov)
  • This RFA, ROLE OF HORMONES AND GROWTH FACTORS IN PROSTATE CANCER, is related to the priority area of hormonal carcinogenesis and prostate disease. (nih.gov)
  • Often, the goal is to treat and control the secondary diseases that develop following prolonged growth hormone hypersecretion (e.g., diabetes mellitus, heart failure, and kidney failure). (petmd.com)
  • What are the side effects of growth hormone treatment? (healthychildren.org)
  • Growth hormone (GH) and/or ghrelin mimetics represent potential treatment and/or prevention options for musculoskeletal impairment associated with aging. (nih.gov)
  • In the past, growth hormone treatment was stopped at the end of growth. (yourhormones.info)
  • The focus will be on fundamental studies of hormone and growth factor action including the mechanisms of action of nuclear hormones, the role(s) of nuclear accessory proteins and the signal transduction pathways important for nuclear hormone action in prostate. (nih.gov)
  • Focus will also be on growth factor action in prostate, including growth factors, binding proteins, receptors and signal transduction pathways. (nih.gov)
  • Peptides are the building blocks of proteins and can act as neurotransmitters or hormones. (genesishealthinstitute.com)