An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
The largest lymphatic vessel that passes through the chest and drains into the SUBCLAVIAN VEIN.
The effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
An encapsulated lymphatic organ through which venous blood filters.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Immunological rejection of tumor tissue/cells following bone marrow transplantation.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Immunological rejection of leukemia cells following bone marrow transplantation.
Obstruction of flow in biological or prosthetic vascular grafts.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)
A phase of the ESTROUS CYCLES that follows METESTRUS. Diestrus is a period of sexual quiescence separating phases of ESTRUS in polyestrous animals.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Small masses of chromaffin cells found near the SYMPATHETIC GANGLIA along the ABDOMINAL AORTA, beginning cranial to the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) or renal arteries and extending to the level of the aortic bifurcation or just beyond. They are also called the organs of Zuckerkandl and sometimes called aortic bodies (not to be confused with AORTIC BODIES in the THORAX). The para-aortic bodies are the dominant source of CATECHOLAMINES in the FETUS and normally regress after BIRTH.
Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)
The period of cyclic physiological and behavior changes in non-primate female mammals that exhibit ESTRUS. The estrous cycle generally consists of 4 or 5 distinct periods corresponding to the endocrine status (PROESTRUS; ESTRUS; METESTRUS; DIESTRUS; and ANESTRUS).
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
A family of neutral serine proteases with CHYMOTRYPSIN-like activity. Chymases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.
Infections by nematodes, general or unspecified.
A genus of intestinal nematode parasites belonging to the superfamily HELIGMOSOMATOIDEA, which commonly occurs in rats but has been experimentally transmitted to other rodents and rabbits. Infection is usually through the skin.
A species of parasitic nematode found in rats.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.
A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Lectin purified from peanuts (ARACHIS HYPOGAEA). It binds to poorly differentiated cells and terminally differentiated cells and is used in cell separation techniques.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.
Symptoms of NAUSEA and VOMITING in pregnant women that usually occur in the morning during the first 2 to 3 months of PREGNANCY. Severe persistent vomiting during pregnancy is called HYPEREMESIS GRAVIDARUM.
Health professionals who practice medicine as members of a team with their supervising physicians. They deliver a broad range of medical and surgical services to diverse populations in rural and urban settings. Duties may include physical exams, diagnosis and treatment of disease, interpretation of tests, assist in surgery, and prescribe medications. (from http://www.aapa.orglabout-pas accessed 2114/2011)
Nurses who are specially trained to assume an expanded role in providing medical care under the supervision of a physician.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
A medical specialty concerned with the provision of continuing, comprehensive primary health care for the entire family.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
The prevailing temper or spirit of an individual or group in relation to the tasks or functions which are expected.
Number of individuals in a population relative to space.
Discussion of lists of works, documents or other publications, usually with some relationship between them, e.g., by a given author, on a given subject, or published in a given place, and differing from a catalog in that its contents are restricted to holdings of a single collection, library, or group of libraries. (from The ALA Glossary of Library and Information Science, 1983)
A list of works, documents, and other publications on medical subjects and topics of interest to the field of medicine.

Adoptive immunotherapy of a Gross virus producing lymphoma and a methylcholanthrene-induced fibrosarcoma in tolerant rats. (1/429)

Immunological tolerance to Gross virus-specific transplantation antigens in rats given neonatae transfer of donor lymphoid cells beneath the kidney capsule of syngeneic recipient rats. Immune or normal donor cells invariably developed a cell-mediated immune reaction in kidneys of GV-tolerant recipients, presumably against GV antigens present on the surface of recipient lymphoid cells in the kidney. Spleen and lymph node cells from tolerant rats failed to develop a reaction in tolerant recipients, but developed a strong reaction to histoincompatible antigens in the kidneys of semisyngeneic tolerant rats. The immunologically tolerant state in the rats could be broken by adoptive transfer of spleen and lymph node cells from syngeneic rats immunized with GV-induced lymphoma cells. Immunotherapy of a GV-induced and also a GV-infected methylcholanthrene-induced fibrosarcoma growing in tolerant rats was successful when immune spleen and lymph node cells were administered i.p. 3 days after s.c. inoculation of 2 X 10(7) tumor cells in the case of the lymphoma, and 1 day after inoculation of 5 X 10(6) tumor cells in the case of the fibrosarcoma.  (+info)

Nitric oxide mediation of active immunosuppression associated with graft-versus-host reaction. (2/429)

In the immunosuppression accompanying the lethal systemic graft-versus-host reaction (GVHR) directed against minor histocompatibility antigens in irradiated adult mice, we previously determined that non-T, non-B, L-leucine methyl ester (LME)-sensitive cells were implicated via two different mechanisms: one, which is interferon-gamma (IFN-gamma)-dependent and affects both T-cell proliferative responses and thymus-independent antibody production by CD5(+) B cells; and a second, which is IFN-gamma-independent and affects B-cell proliferative responses. Because IFN-gamma induces the production of nitric oxide (NO), a potent immunosuppressive molecule, we investigated the involvement of NO in the suppression mediated by the LME-sensitive cells. Inducible NO synthase (iNOS) mRNA, iNOS protein, and the stable end products of iNOS pathway, L-citrulline and nitrite, were detected early in GVHR in LME-sensitive spleen cells taken ex vivo and could be amplified in vitro by T and B mitogens. Inhibition of NO production with arginine analogs (aminoguanidine, N(G)-monomethyl-L-arginine [LMMA]), like anti-IFN-gamma antibodies, reversed suppression of both T-cell responses to concanavalin A and CD5(+) B-cell responses, but not of B-cell response to lipopolysaccharides (LPS). The GVHR-associated, IFN-gamma-dependent immunosuppression of T-cell proliferation and of antibody synthesis by CD5(+) B cells is the consequence of NO production by LME-sensitive cells. Immunohistochemical analyses indicate that these cells belong to the macrophage lineage.  (+info)

Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia. (3/429)

We demonstrate an increase in graft-versus-host disease (GVHD) after experimental bone marrow transplant (BMT) when cyclophosphamide (Cy) is added to an otherwise well-tolerated dose (900 cGy) of total body irradiation (TBI). Donor T cell expansion on day +13 was increased after conditioning with Cy/TBI compared with Cy or TBI alone, although cytotoxic T lymphocyte (CTL) function was not altered. Histological analysis of the gastrointestinal tract demonstrated synergistic damage by Cy/TBI and allogeneic donor cells, which permitted increased translocation of LPS into the systemic circulation. TNF-alpha and IL-1 production in response to LPS was increased in BMT recipients after Cy/TBI conditioning. Neutralization of IL-1 significantly reduced serum LPS levels and GVHD mortality, but it did not affect donor CTL activity. By contrast, neutralization of TNF-alpha did not prevent GVHD mortality but did impair CTL activity after BMT. When P815 leukemia cells were added to the bone marrow inoculum, allogeneic BMT recipients given the TNF-alpha inhibitor relapsed at a significantly faster rate than those given the IL-1 inhibitor. To confirm that the role of TNF-alpha in graft versus leukemia (GVL) was due to effects on donor T cells, cohorts of animals were transplanted with T cells from either wild-type mice or p55 TNF-alpha receptor-deficient mice. Recipients of TNF-alpha p55 receptor-deficient T cells demonstrated a significant impairment in donor CTL activity after BMT and an increased rate of leukemic relapse compared with recipients of wild-type T cells. These data highlight the importance of conditioning in GVHD pathophysiology, and demonstrate that TNF-alpha is critical to GVL mediated by donor T cells, whereas IL-1 is not.  (+info)

Vaginal outflow tract obstruction by graft-versus-host reaction. (4/429)

We describe a 25-year-old patient suffering from vaginal outflow obstruction which presented as secondary amenorrhea during hormone replacement therapy. The patient had undergone bone marrow transplantation for acute myelocytic leukemia, which caused ovarian failure. Oral mucositis associated with a chronic GVH reaction also occurred. For 3 years she was treated with HRT and had regular menses which gradually ceased and were associated with dyspareunia and abdominal cramps. Abdominal US examination demonstrated hematocolpus. Sonography guided adhesiolysis of a dense vaginal obstruction allowed free drainage with histologic confirmation of a graft-versus-host reaction. The possibility of vaginal stricture or obstruction should be considered in all patients after BMT who suffer from graft-versus-host disease.  (+info)

Visualization, fate, and pathogenicity of antigen-specific CD8+ T cells in the graft-versus-host reaction. (5/429)

To follow the fate of alloreactive T cell effectors in graft-vs-host disease, Ld-specific CD8+ T cells from C57BL/6 2C TCR-transgenic donors were transplanted into sublethally irradiated (750 cGy) Ld+ or Ld- recipients. In Ld- C57BL/6 or (BALB/c-dm2 x C57BL/6)F1 recipients, naive 2C T cells engrafted and survived long term, but did not acquire effector function. In Ld+ (BALB/c x C57BL/6)F1 recipients, 2C T cells engrafted, expanded, became cytolytic, destroyed host B cells and double-positive thymocytes, and later disappeared. Despite marked damage to lymphoid and hemopoietic cells by 2C T cells, no significant pathology was detected in other organs, and recipients survived. Ld+ (BALB/c x C57BL/6)F1 recipients died when LPS/endotoxin was administered on day 7 after cell transfer, while Ld- (BALB/c-dm2 x C57BL/6)F1 recipients survived. Our findings show that under certain conditions, a CD8+ T cell population recognizing an extremely limited repertoire of Ags can initiate graft-vs-host disease.  (+info)

Photochemical treatment with S-59 psoralen and ultraviolet A light to control the fate of naive or primed T lymphocytes in vivo after allogeneic bone marrow transplantation. (6/429)

Donor leukocyte infusions after allogeneic bone marrow transplantation can provide a curative graft-vs-leukemia (GVL) effect, but there is a significant risk of graft-vs-host (GVH) disease. A simple and effective method for controlling the fate of naive or primed T-lymphocytes in vivo without eliminating their beneficial properties is needed. In this report, photochemical treatment (PCT) ex vivo with a synthetic psoralen (S-59) and UVA light was evaluated as a pharmacological approach to limiting the proliferation and GVH potential of naive and primed donor T cells in vivo. S-59 rapidly intercalates into and cross-links DNA on UVA illumination. The effects of PCT on T cells were found to be both S-59 and UVA dose dependent. With selected PCT regimens, treated T cells still expressed activation markers (CD25 and CD69) and secreted IL-2 on activation, but they showed limited proliferative capacity in vitro and in vivo. Clonal expansion of CTL in MLR was reduced after PCT, but short term lytic activity of primed CTL was not affected. In a murine model of MHC-mismatched bone marrow transplantation, the addition of PCT-treated T cells to T-depleted bone marrow facilitated donor engraftment and complete chimerism without causing acute or chronic graft-vs-host disease. Allospecific GVL reactivity was reduced but not eliminated after PCT treatment. In an MHC-matched model using host-presensitized donor T cells, PCT significantly reduced GVH-associated mortality without eliminating GVL reactivity. Thus, PCT ex vivo offers a simple, rapid, and inexpensive method by which to control the fate of naive and primed T cells in vivo.  (+info)

Induction of autoimmunity in a transgenic model of B cell receptor peripheral tolerance: changes in coreceptors and B cell receptor-induced tyrosine-phosphoproteins. (7/429)

Abrogation of peripheral tolerance in transgenic mice that express a uniform B-cell receptor may create a powerful tool to examine the molecular mechanisms that underlie the autoimmune response in B cells. Here we report that processes that induce a systemic lupus erythematosus-like syndrome in normal mice, namely chronic graft vs host reaction, trigger systemic autoimmunity in a well-established transgenic mice model of B cell receptor peripheral tolerance. The induction of graft vs host reaction in mice that carry both a rearranged B cell Ag receptors specific for hen egg lysozyme and expressing chronically circulating hen egg lysozyme Ag resulted in induction of high and sustained levels of circulating anti-hen egg lysozyme autoantibodies and glomerulonephritis with proteinuria. This was associated with marked changes in expression of cell-surface proteins, such as CD23 and complement receptor 2. B cells from the graft vs host-induced mice could proliferate in vitro in response to self-Ag, and upon stimulation with anti-IgD demonstrated rapid phosphotyrosine phosphorylation of specific proteins, which could not be induced in the anergic double transgenic B cells. Conversely, loss of tolerance was not associated with a higher induction in the level of Syk kinase phosphorylation following stimulation with anti-IgD. Taken collectively, these data establish that 1) processes that induce a systemic lupus erythematosus-like syndrome in normal mice can abrogate peripheral tolerance in transgenic mice expressing self-tolerized B cells, and that 2) loss of tolerance in this model is associated with marked changes in surface expression of B cell coreceptors as well as with selective changes in IgD-induced signaling by discrete tyrosine-phosphoproteins, but not Syk kinase.  (+info)

Effects of graft-versus-host reaction on intrahepatic islet transplants. (8/429)

The use of donor-specific bone marrow transplantation might represent a valuable approach for the induction of hyporesponsiveness to concurrent allogeneic organ and tissue grafts. In this setting, the occurrence of subclinical forms of graft-versus-host reaction (GVHR) can seldom be formally ruled out. When systemic administration of donor-specific bone marrow is performed together with intraportal transplantation of islets of Langerhans, GVHR might damage the implanted islets through an innocent bystander mechanism. The liver is, in fact, a prominent target of GVHR, and islets are sensitive to the noxious effects of proinflammatory mediators, including selected cytokines produced during GVHR. A parent (Lewis) to F1 (Lewis x Brown Norway) splenocyte transfer model was used to induce GVHR in rats. Islets were also obtained from Lewis donors and implanted into F1 recipients to examine the effects of GVHR on islet function in the absence of rejection. Selected doses of splenocytes were infused in F1 recipients to induce GVHR. When 150 x 10(6) cells were administered, all recipients developed clinical lethal GVHR. When 100 x 10(6) or 80 x 10(6) cells were given, lethal GVHR was observed in 40 and 20% of the F1 animals, respectively. A transient clinical syndrome occurred in the remaining animals and spontaneously subsided; histological findings consistent with persistent low-grade GVHR were observed in these animals at the time of death several months after splenocyte inoculation. When simultaneous splenocyte infusions and islet grafts were performed in chemically diabetic animals, no adverse effect of either clinical or subclinical GVHR was observed on islet function. Blood glucose profiles were normal, as were intravenous glucose tolerance test profiles. In conclusion, GVHR does not seem to adversely influence function of islets of Langerhans implanted intrahepatically in this parent to F1 experimental model.  (+info)

Allogeneic immune cells, particularly T cells in donor grafts, recognize and eliminate leukemic cells via graft-versus-leukemia (GVL) reactivity, and transfer of these cells is often used for high-risk hematological malignancies, including acute myeloid leukemia. Unfortunately, these cells also attack host normal tissues through the often fatal graft-versus-host disease (GVHD). Full separation of GVL activity from GVHD has yet to be achieved. Here, we show that, in mice and humans, a population of interleukin-9 (IL-9)-producing T cells activated via the ST2-IL-33 pathway (T9IL-33 cells) increases GVL while decreasing GVHD through two opposing mechanisms: protection from fatal immunity by amphiregulin expression and augmentation of antileukemic activity compared with T9, T1, and unmanipulated T cells through CD8α expression ...
In retrospect, it seems obvious that effective immunity requires the coordinated activities of many cell types. Given their functional specialization and differences in lifespans, it makes sense that different kinds of lymphocytes are initially generated and then replenished in separate sites. There were tantalizing clues to this in the early 1960s, but a remarkable convergence of clinical findings and studies with experimental animals was needed to delineate clearly the origins of what now are known as B and T cells. Using a chicken model, Max Cooper first showed that the cells that derived from the bursa of Fabricius were responsible for Ab production, whereas the thymus-derived cells were the effectors of delayed-type hypersensitivity and graft vs host reactions (1, 2).. Modifying methods developed by Glick, Warner, and others (3, 4), Cooper combined surgical thymectomy and/or bursectomy of posthatched chickens with sublethal irradiation. This novel strategy effectively eliminated lymphocytes ...
In this paper, five points are summarized: 1 What is a graft-versus-host disease (reaction). 2 When and why does it occur. 3 What is the spectrum of its cutaneous manifestations. 4 What is (are)...
Supplementary Materialsimmunology. Rotation desk extracted from PCA. Sources ( em 92 /em C em 100 /em ) Abstract Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We determined intensive activation and induction of multiple immune system lineages, including T cell activation, oligoclonal plasmablast enlargement, and trafficking and Fc receptor modulation on innate lymphocytes and granulocytes, that recognized serious COVID-19 cases from healthy donors or moderate or SARS-CoV-2-recovered severity individuals. We found out the neutrophil to lymphocyte percentage to be always a prognostic biomarker of disease body organ and severity failing. Our results demonstrate wide innate and adaptive leukocyte perturbations that differentiate dysregulated SC 66 host reactions in serious ...
Dr McGee is referring Tyler back to SCCA for testing and possible treatment. Most likely, Tyler would get a Donor Lymphomcyte Infusion. This is like a booster shot of white blood cells from his father, that should stimulate the marrow to attack the leukemia cells that are floating around in there. The goal of this treatment is to get Tyler back into full remission, but would likely cause a recurrence and possibly an increase in Tylers Graft vs Host (GVHD) symptoms, but would also increase the Graft vs. Leukemia effect (beneficial). I know this all sounds very complicated, but we are working through this and finding out about the procedure ...
Zaleski, M, Effect of host-versus-graft and graft-versus-host reactions on the immune response of mice to sheep red blood cells. (1971). Subject Strain Bibliography 1971. 764 ...
T cell mediated immune responses in the gut can produce enteropathy and malabsorption. We have investigated the relevance of mucosal mast cells (MMC) to the mechanisms of this enteropathy by using graft-versus-host reaction (GvHR) in the rat as a model of mucosal delayed type hypersensitivity. Measurements of mucosal architecture, intraepithelial lymphocytes (IEL) and MMC counts were performed in control and experimental rats, and release of rat mast cell protease II (RMCPII) into the bloodstream was used as an index of MMC activation. In unirradiated rats, jejunal MMC count was increased on day 14 of the GvHR (mean 272/mm2 v 182 in controls, p less than 0.01), as was serum RMCPII (p less than 0.01). Irradiated rats (4.5 Gy, reconstituted with isogeneic spleen cells) had low counts of IEL and crypt hyperplasia seven to 14 days after irradiation. Irradiated rats with GvHR (induced by ip injection of parental strain spleen cells) and studied on days 7, 10 and 14, had significant enteropathy with ...
Twenty-six patients participated in a randomized, double-blind study of the efficacy of total lymphoid irradiation in the treatment of intractable rheumatoid arthritis. All 26 patients, for whom therapy with gold compounds and penicillamine had failed, would ordinarily have been considered candidates for cytotoxic or antimetabolite drug therapy. Thirteen patients randomly assigned to receive full-dose total lymphoid irradiation (2000 rad) and 11 patients assigned to receive control low-dose total lymphoid irradiation (200 rad) completed radiotherapy. Alleviation of joint disease activity was significantly greater in the high-dose group as judged by morning stiffness, joint tenderness, and functional assessment (global composite score) at 3 and 6 months after radiotherapy. The high-dose group had a marked reduction in both T-lymphocyte function and numbers, but this finding was not observed in the low-dose group. Complications seen in the high-dose but not low-dose group included transient ...
in Archivos Argentinos de Dermatologia (1998), 48. One of the most important complications associated with bone marrow transplantation (BMT) is graft-versus-host reaction (GVHR) altering different organs. The immunosuppressive regimen frequently abates ... [more ▼]. One of the most important complications associated with bone marrow transplantation (BMT) is graft-versus-host reaction (GVHR) altering different organs. The immunosuppressive regimen frequently abates the severity of cutaneous lesions to a peculiar lymphocyto-depleted GVHR (LD-GVHR) with scant recognizable inflammatory cells and almost absence of epidermal injury. The recently revisited histological criteria for cutaneous GVHR are of little help in diagnosing such LD-GVHR. As calprotectin (L1-protein) has been reported to be expressed in several types of stressed epithelia, we assessed the epidermal calprotectin expression during LD-GVHR. Calprotectin expression was studied by immuno-histochemistry using the Mac 287 moAb in 50 ...
Restoration of chronic graft vs host disease (Cgvhd)-induced autoantibody (autoAb) by human granulocyte-colony stimulation factor (huG-CSF) correlates with CD4+
Lymphocytes T Cytotoxiques 0 questions Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from natural killer cells (KILLER CELLS, NATURAL) and from KILLER CELLS mediating antibody-dependent cell cytotoxicity. There are two effector phenotypes: TC1 and TC2. ...
Pathogens such as influenza have evolved to use hosts to promote their growth, while at the same time blocking the host reactions that recognize and respond to infection. Each year, for example, winter is marked by the outbreak of flu caused by new viruses that the human immune system doesnt recognize ...
A simple questionnaire that rates breathing difficulties on a scale of 0 to 3 predicts survival in chronic graft-vs.-host disease (GVHD), according to a current study.
He is experiencing some Graft vs Host Disease (GVHD) in the form of a skin rash on his body - this is actually a positive as it shows that the new immune system is working and recognizing foreign objects (in this case Brandon). They will keep this under control with medication ...
In the meantime, the medical team was debating on whether they should split the harvested cells or give the entire bounty to her on this day. If I understand, the trade-offs at play here are effectiveness against the cancer versus the risk of Graft vs. Host Disease. The greater number of my cells given to her, the greater effect against the cancer but also the higher the risk of GvHD. Dr. Hamati, the transplant doctor, made the decision to give all the cells right away without freezing any. Given how closely our HLA (Human Leukocyte Antigens) matched, it seemed as though Dr. Hamati didnt consider GvHD to be as big a threat as it can be in some cases. With that, the labs work on the product was reduced and the transplant proceded mush sooner ...
Graft vs. Host disease (GVHD) often occurs after allogeneic bone marrow transplants (BMT). In GVHD, the donors bone marrow attacks the patients organs and tissues, making them less able to function well.
TY - JOUR. T1 - A synergistic effect of total lymphoid irradiation, cyclosporine, and splenectomy in a hamster-to-rat hepatic xenograft model. AU - Yamaguchi, Y.. AU - Halperin, E. C.. AU - Harland, R. C.. AU - Wyble, C.. AU - Bollinger, R. R.. PY - 1989/12/1. Y1 - 1989/12/1. UR - UR - M3 - Article. C2 - 2662528. AN - SCOPUS:0024909116. VL - 21. JO - Transplantation Proceedings. JF - Transplantation Proceedings. SN - 0041-1345. IS - 3. ER - ...
TY - JOUR. T1 - Pathophysiologic mechanisms of acute graft-vs.-host disease. AU - Ferrara, James L M. AU - Levy, Robert B. AU - Chao, Nelson J.. PY - 1999/12/1. Y1 - 1999/12/1. N2 - Graft-vs.-host disease (GVHD) remains the major toxicity of allogeneic bone marrow transplantation. Mechanistic studies in experimental animal models provide a better understanding of the complex relationships and cascade of events mediated by cellular and inflammatory factors. Also, advances in basic immunology have cleared the way for a more precise view of allogeneic reactions between donor and host. In addition, the use of mutant mice lacking critical cytolytic proteins has helped map out the molecular pathways by which GVHD targets organ damage. In this article, these mechanisms are reviewed and synthesized into a coherent conceptual framework, providing a state-of-the-art summary of the pathophysiology of acute GVHD.. AB - Graft-vs.-host disease (GVHD) remains the major toxicity of allogeneic bone marrow ...
Skopinska, E, Some effects of escherichia coli endotoxin on the graft-versus-host reaction in mice. (1972). Subject Strain Bibliography 1972. 2753 ...
In clinical bone marrow (BM) transplantation, graft-versus-host reaction can be effectively prevented by depleting the graft of T cells. However, transplantation of T-depleted grafts is complicated...
Colonisation = the presence of organisms in a wound that are multiplying but causing negligible host reaction. Colonisation can have a detrimental effect on wound healing, but as the classic signs of infection do not accompany it, is often not identified ...
The rejection of transplanted tissue by the recipient body is often life-threatening, but it can, in controlled form, be exactly what the doctors are looking for. New cancer therapies using transplanted blood stem cells are based on exploiting graft-versus-host reactions to attack the disease.
This most recent volume of this series contains six contributions that cover three areas of immunology. Three chapters deal with the subjects related to transplantation: the graft-versus-host reaction, immunologic enhancement, and cross-reactivity between tissue and microbial antigens. Two chapters are concerned with current topics in cellular immunology: the antigen receptor site and the cellular basis of memory. The chapter on the immunology of chronic hepatitis is the most obviously clinical chapter; however, each author makes an effort to relate his subject to practical problems in immunology.. In the essay, Blood Group and Forssman Antigenic Determinants Shared Between Microbes and Mammalian ...
Additionally, IL-1RAcP is required for IL-33-induced in vivo effects, and IL-33-mediated signal transduction can be inhibited by dominant-negative IL-1RAcP. Results of the round window electrical stimulation in 460 cases of total deafness. Donor hematopoiesis in mice following total lymphoid irradiation requires ...
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Semantic Scholar extracted view of Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemia. by Tae Hun Kim et al.
Four different combinations of F1 hybrid mice [(C57BL/10 X B10.A)F1, (C57BL/10 X B10.BR)F1, B6D2F1, and AKD2F1] were injected intravenously with spleen cells from parental strains. The T-cell-mediated cytotoxic potential of spleen cells from the injected F1 mice was assessed from 4 to 21 d later by in vitro sensitization with trinitrophenyl-modified parental or syngeneic F1 spleen cells (TNP-self) or with allogeneic spleen cells. The cytotoxic potential of the F1 mice to TNP-self as well as to alloantigens was abolished or severely depressed throughout this period when the respective H-2k,a,d parental spleen cells were injected. In contrast, the cytotoxic potential was unaffected or only marginally reduced when H-2b parental cells were injected. The induction of depressed cytotoxic activity was shown to be a result of a population of parental radiosensitive T lymphocytes. The results should be discussed with respect to (a) the genetic and mechanistic parameters associated with the differential ...
If you are a bone marrow transplant recipient with symptoms of GvHD, talk to your doctor as soon as possible. During your visit, tell your doctor about all of your symptoms, no matter how minor they may seem. If your doctor suspects you have GvHD, you will receive a blood test. This test will look for high levels of white blood cells, which usually indicate an infection.. If your test shows a high white blood cell count, you may need a tissue biopsy. The biopsy is usually performed while you are under sedation. It can also be performed with just a local anesthetic. A small piece of tissue will be removed from the area affected by GvHD. It will then be sent to the lab and tested for abnormalities. In many cases, a urinalysis (urine test) will also be used to detect signs of infection. Urine tests can be used to rule out conditions such as diabetes or bladder infections.. ...
B cells, which produce proteins called antibodies, are one type of immune cell involved in GVHD. In a paper published in the journal, Blood, a team from the University of North Carolinas Lineberger Comprehensive Cancer Center, shows in the laboratory that B cells from patients with chronic GVHD are much more active than cells from patients without the disease. The team also outlines the cell signaling pathways that contribute to this increased activity -- identifying a promising target for developing new therapies for the diseases.
The next proposed course of action is a round or so of rituximab (the drug that worries me so much), along with total lymphoid irradiation and possibly cytoxan administered intravenously. We dont know if plasmapheresis and IVIG are still to be part of the mix, or if theyve been relegated to the scrap heap of ineffective treatments. For the first time in some time, we are again hearing murmurs that some form of external assist device might become necessary at some point. Sorry for all the medical-speak -- its virtually impossible to explain these things any more easily. Suffice it to say that Patty has worked her way, without real success, through most of the traditional solutions to the antibodies issue, and is now trying lesser-tested approaches in the hope something tips the scales in her favor ...
Collaboration to identify and characterize leukemia-specific T‑cells in ATIR, responsible for the Graft-versus-Leukemia effect of the immunotherapy product.
The vector Circulifer tenellus was used to inoculate 60 species of plants with the beet leafhopper-transmitted virescence agent (BLTVA). A wide range of host reactions was seen in 43 species, including floral gigantism, host induction response, internode elongation, internode shortening, leaf deformation, leaf mottling, proliferation, stunting, tip necrosis, virescence, wilting, and yellowing. No nonsymptomatic hosts were found, but 17 plant species did not develop symptoms of infection after exposure to inoculative leafhoppers; this included all the monocots tested. A number of plants that have been reported as hosts of economically important MLO diseases also proved to be hosts of BLTVA. In seven host species, flowering was induced in plants grown under environmental conditions that would normally be noninductive for flowering.. ...
Heniford BT. Immunohistochemical analysis of host reaction to heavyweight-, reduced-weight, and expanced polytetrafluoroethylene (ePTFE)-based meshes after short- and long-term intraabdominal implantations. Surg Endosc. 2008 Apr;22(4):1070-6. Epub 2008 Jan 11.. Chapters. Harrell AG, Novitsky YW, Kercher KW, Heniford BT. Ventral Herniation in Adults. In: Yeo CJ, editor. Shackelfords Surgery of the Alimentary Tract, 6th Edition. Philadelphia: W. B. Saunders, 2007.. Zerey M, Harrell AG, Kercher KW, Heniford BT. Minimally Invasive Surgery Training: State of the Art. In: Park A, Witzke D, editors. Minimally Invasive Surgery Training: State of the Art: An Electronic Book. In press.. Oral Presentations. Harrell AG, Novitsky YW, Foster M, Burns J, Matthews BD, Kercher KW, Heniford BT. Prosthetic Mesh Biomaterial Susceptibility to Methicillin-Resistant Staphylococcus aureus Adherence in an In-Vitro Model. American Hernia Society. San Diego, CA, February 2005. Rosen MJ, Kercher KW, Novitsky YW, Cobb WS, ...
His right eye was even more red than normal and seemed to be oozing a little bit on Saturday. On Sunday and Monday, his eyes actually crusted shut as he slept overnight and continued to ooze all day long. We were worried because he has had eye sensitivity from the lack of tears (which is most likely mild Graft vs Host Disease) and this new symptom seemed to coincide with a new reduction in his tacrolimus (the immunosuppressant drug). Hes been reducing one of his two daily doses every couple of weeks or so. He is on .5 mg in the morning and evening this week, then .5 mg in the morning and 0 in the evening next week, and then he is DONE!!! This means we are rapidly approaching our important 6 month mark ...
Hi, I am a 41 year old female who was Dx with MM when I was 38. I was at stage three with 50% cancer cells. I tried the Autologus transplant first which is where they use my own stem cells. It took four months of chemo before the actual transplant and then three months isolation after the one month stay in the hospital. I was feeling good for about 7 months and then relapsed. In March of this year, 2003, I had the Allogenic transplant using my sisters stem cells. Although I have not completed the first 100 days yet, I can already tell Im doing much better. I will have follow up tests the end of June to see how well this worked. Of course the big fear was the GVH disease, but I have been good, taken my meds, eat the right things and have been very blessed that I have not had any signs of it. I met a girl at clinic who did end up with it and although she looked thin, she seemed to be doing great. What city do you have to move to in order to get your transplant? I was lucky, the U of M is right in ...
ICD-9 code 279.50 for Graft-versus-host disease, unspecified is a medical classification as listed by WHO under the range - OTHER METABOLIC AND IMMUNI
Gazdasági Versenyhivatal (Hungarian Competition Authority) H-1054 Budapest, Alkotmány u. 5. Postal address: H-1391 Budapest 62, POBox 211 Telephone: (0036) 1-472-8900; Fax: (0036) 1-472-8905 ...
You will need to guard against infection for many months after transplant, longer if you are on drugs to control graft-versus-host disease.
Rat bone marrow is deficient in immunologically competent cells when compared with the peripheral pool of circulating small lymphocytes. However, circulating lymphocytes capable of initiating a lethal graft vs. host reaction can develop from myeloid precursors. In adult rats inoculated at birth with parental strain bone marrow cells, the thoracic duct lymph contains cells having the immunological capability of the marrow donor. The evidence suggests that immunologically competent lymphocytes derive from cells normally resident in bone marrow and probably not from precursors in the peripheral lymphocyte pool.. ...
Discussion. Infections occur through inhalation of yeast-like organisms which enter smaller respiratory passages and then remain dormant depending on the host reaction.6 The pigeon appears to be the chief vector for the distribution and maintenance of Cryptococcus neoformans. The organism is usually found in debris in pigeon roosts or other bird nests.7 Direct inoculation through the skin may also occur.5 There are two types of Cryptococcus neoformans infections, but the manifestation depends on the host response rather than the strain of the organism,8 with infection rarely occurring in immuno-competent hosts.9 The first type occurs in immuno-compromised individuals where the infection spreads rapidly to involve most organ systems, especially the central nervous system (CNS). The second occurs in immuno-competent individuals where the bodys natural defence mechanism prevents systemic disease. In these cases organisms can be disseminated haematogenously to distal sites, where re-activation can ...
Less Common Adverse Reactions. The following adverse reactions occurred in ,2% of all voriconazole-treated patients in all therapeutic studies (N=1655). This listing includes events where a causal relationship to voriconazole cannot be ruled out or those which may help the physician in managing the risks to the patients. The list does not include events included in Table 4 above and does not include every event reported in the voriconazole clinical program.. Body as a Whole: abdominal pain, abdomen enlarged, allergic reaction, anaphylactoid reaction [see Warnings and Precautions (5.3)], ascites, asthenia, back pain, chest pain, cellulitis, edema, face edema, flank pain, flu syndrome, graft versus host reaction, granuloma, infection, bacterial infection, fungal infection, injection site pain, injection site infection/inflammation, mucous membrane disorder, multi-organ failure, pain, pelvic pain, peritonitis, sepsis, substernal chest pain.. Cardiovascular: atrial arrhythmia, atrial fibrillation, ...
Procedure Description. During this treatment we will collect 30-60mls of your own blood. Then we will spin your blood in a centrifuge, which separates out plasma and platelets via a special filter. The PRP portion of your blood is then injected backed into your skin mixed with ACell to stimulate new collagen, hair cell growth, and cell rejuvenation. The product injected is 100% a by-product of your own blood (autologous).. ACell produces extracellular matrix (ECM), the by-product of porcine urinary bladder tissue that has proven regenerative properties. The product is stripped of all cells, as well as muscle tissue, to prevent graft-versus-host reactions (allergic reactions) when introduced in humans.. ACells ECM also provides growth factors and proteins necessary for tissue regeneration and sets up a temporary non-cross-linked scaffolding for the tissue reconstruction that mimics the surrounding healthy-but-damaged tissue. This scaffolding contains and slowly releases growth factors (VEGF ...
This study will evaluate if TLI-ATG conditioning followed by allogeneic hematpoietic cell transplant (HCT), which has provided excellent overall survival for patients with relapsed lymphoma after failed autologous HCT, provides a similar benefit in the setting of elderly patients with hematologic malignancies ...
TY - JOUR. T1 - Antibody synthesis by transferred lymphoid cells. T2 - The influence of the host genetic environment on the duration of the immune response. AU - Wakefield, June D.. AU - Rose, Noel R.. PY - 1968. Y1 - 1968. N2 - Spleen cells from 129/JaxHe and C3H/He mice, actively immunized with bovine serum albumin, were transferred to 129/ JaxHe, C3H/He, and F1 hybrids of these strains. Grafts of spleen cells from the two strains showed similar patterns of behavior, in that the antibody to bovine serum albumin was detectable for at least 60 days in syngenie recipients when male spleen cells were transferred to male recipients. Females accepted male cells transiently; antibody rarely was present at the 4th week. Parental spleen cells produced antibody for limited periods of 1 month in F1 mice. The two mouse strains differed in their responsiveness to certain grafts of skin. Female 129 mice rejected male 129 skin grafts, whereas C3H females appeared to accept grafts of C3H male skin. Such ...
Following allogenic hematopoietic stem cell transplantation (HSCT), patients with autoimmune disease or hematopoietic malignancy may develop acute or chronic graft-versus-host (GvH) disease. B lymphocytes, from the recipient as well as from the donor, have recently been implicated in the pathogenesis of such disturbances. Their deleterious effects are accounted for by other tasks B lymphocytes accomplish than the antibody production. We highlight herein some recent observations in the context of B cells in the GvH disease.
GVHD may cause severe eye dryness that results in permanent vision loss without treatment.. Hematologic stem cell transplantation is commonly used to repair the immune system following high intensity radiation treatment. Simply put, a donor gives healthy blood to somebody with a weakened immune system to jump start their immunity and prevent them from becoming sick.. It is common for the new blood cells (the graft) to view the recipient (the host) tissue as foreign. This results in tissue damage, often targeting the tear glands of the eyes. This is termed Ocular Graft versus Host Disease (GVHD). Damaged tear glands tend to stop working well, if at all, and result in a severely dry eye surface. This dryness is painful, debilitating, and may cause permanent vision loss if not treated quickly.. The solution? Scleral contact lenses. These lenses restore the ability to live a day without worrying whether or not your eye irritation will keep you in bed all day.. Schedule a Scleral contact lens ...
ANN ARBOR, Mich. - A natural enzyme derived from human blood plasma showed potential in significantly reducing the effects of graft-vs.-host disease, a common and deadly side effect of lifesaving bone marrow transplants.. Researchers from the University of Michigan Comprehensive Cancer Center looked at the drug alpha-1-antitrypsin, which is approved by the U.S. Food and Drug Administration for use in people who have a genetic mutation that makes them deficient in a certain enzyme. This drug has been used in many of these patients over extended periods of time and is known to cause minimal side effects.. More important, there are no known reports of increased susceptibility to infections. This is key for people with graft-vs.-host disease, where existing treatment options tend to suppress the immune system, putting patients at risk of infection. Graft-vs.-host disease is a major complication of bone marrow transplants using marrow from a donor, called an allogeneic transplant. This often-deadly ...
Abstract. BACKGROUND: Chronic GVHD is a major determinant of quality of life after allogeneic HCT. Systemic immunosuppressants (IS) are the mainstay of treatme
Reviews and ratings for deltasone when used in the treatment of graft-versus-host disease. Share your experience with this medication by writing a review.
The docs were concerned that he might be experiencing a little of the Graft vs. Host disease in his gut based on his poop output and some tummy & chest pain. Nothing major and nothing too serious and in fact its quite common post transplant. Its treated with steroids and most likely just goes away. The doctor that performed the procedure turned over some really wonderful photos of Hunters insides..........a few sides of him that I have never seen before. Didnt think there were any left??? So now we have just a few more wonderful pics for Hunters baby book. Ill put those right next to his little foot prints and his little ringlet of hair...............that has now fallen out twice. But good news is that peach fuzz has officially been spotted on his YAY.....his curls will be back soon ...
respond to host antigens.Current consensus is that clinical manifestations guide whether the signs and symptoms of graft-versus-host disease (GVHD) are acute, chronic, or an overlap syndrome.Acute GVHD classically targets the skin, liver, and…. ...
Clark DA, Chaput A, Tutton D (March 1986). "Active suppression of host-vs-graft reaction in pregnant mice. VII. Spontaneous ... This is the same mechanism used by parasitic nematodes to avoid detection by the immune system of their host. Also, there is ... Antinuclear antibodies cause an inflammation in the uterus that does not allow it to be a suitable host for implantation of the ...
Clark DA, Chaput A, Tutton D (March 1986). "Active suppression of host-vs-graft reaction in pregnant mice. VII. Spontaneous ... This is the same mechanism used by parasitic nematodes to avoid detection by the immune system of their host. There is presence ...
Clark DA, Chaput A, Tutton D (March 1986). "Active suppression of host-vs-graft reaction in pregnant mice. VII. Spontaneous ...
Chronic graft-versus-host disease The history of preceding hematopoietic cell transplant is helpful for diagnosis Psoriasis ... Sometimes dental materials or certain medications can cause a lichenoid reaction. They can also occur in association with graft ... Vargas-Díez E, García-Díez A, Marín A, Fernández-Herrera J (May 2005). "Life-threatening graft-vs-host disease". Clinics in ... mainly Hypersensitivity reaction Restorative material (e.g. amalgam and composite) or drugs can cause hypersensitivity reaction ...
"Pathogenesis of a local graft versus host reaction: immunogenicity of circulating host leukocytes". Science. 159 (3820): 1250-1 ... 210-1. ISBN 978-88-470-0374-3. Snell, George D. (1957). "The homograft reaction". Annual Review of Microbiology. 11: 439-58. ... by George Davis Snell and the term coined in 1968 when Elkins and Guttmann showed that leukocytes present in a donor graft ...
Elkins, W.R., Guttmann, R.D.: Pathogenesis of a local graft versus host reaction. Immunogenicity of circulating host leucocytes ... Guttmann, R.D., Kraus, E.D., Dolan, M.F.: Rejection of isogeneic murine skin grafts following exposure to allogeneic ...
Graft-versus-host disease (GVHD)[edit]. Lacy, reticulated plaques or erosions that resemble oral LP may occur in GVHD. The ... Oral lichenoid contact reaction (allergic contact mucositis)[edit]. Oral lichenoid contact reactions may be caused by a variety ... Vargas-Díez E, García-Díez A, Marín A, Fernández-Herrera J (May 2005). "Life-threatening graft-vs-host disease". Clinics in ... Chronic graft-versus-host disease *The history of preceding hematopoietic cell transplant is helpful for diagnosis ...
... graft versus host reaction, GVHR); rejection of H2-incompatible grafts (skin, heart, bone marrow, etc.) by the recipients; and ... Skin grafting and other methods indicated inbreeding within the demes, but sharing of certain alleles between the demes ... were also responsible for the rejection of incompatible grafts. Klein, with his coworker Vera Hauptfeld and his wife Dagmar ... The cells with receptors for self-molecules must be eliminated to prevent an immune reaction against the individual's own ...
His most important contribution to embryology was in his early investigation of the "graft-host" reaction. This seminal work ...
"Active suppression of host-vs-graft reaction in pregnant mice. VII. Spontaneous abortion of allogeneic CBA/J x DBA/2 fetuses in ...
In acute graft-versus-host disease, the most common hematologic adverse reactions include anemia, thrombocytopenia, and ... In the United States, ruxolitinib is also indicated for the treatment of steroid-refractory acute graft-versus-host disease in ... and steroid-refractory acute graft-versus-host disease. It was developed and marketed by Incyte Corp in the US under the brand ... The most common nonhematologic adverse reactions include infections and edema. Immunologic side effects have included herpes ...
Other side effects have included diarrhea, nosebleeds, sepsis, graft vs host disease, and pneumonia. Pregnant women should not ... There is a high risk of bleeding and some people have had hypersensitivity reactions to defibrotide. Common adverse effects, ... Some people have hypersensitivity reactions. Defibrotide was approved for medical use in the European Union in October 2013, in ... and allergic reactions. Defibrotide should not be used in people who are having bleeding complications or who are taking blood ...
One hypothesis is that these fetal cells might trigger a graft-versus-host reaction leading to autoimmune disease. This offers ... The fetal microchimerism may trigger a fetus versus host reaction and therefore may play a role in the pathogenesis of ... Two types of thyroid disease, Hashimoto's Thyroiditis (HT) and Graves' Disease (GD) show similarities to graft vs host disease ... or acuteness of bone marrow transplantation graft-versus-host disease is reduced, when recipients of donor stem cells are NIMA- ...
Penninger J, Hála K, Wick G. "Inrathymic nurse cell lymphocytes can induce a specific graft-versus-host reaction." J Exp Med ... Chicken TNC-T cells exhibit greater graft vs host reactivity than peripheral blood T cells or ET cells when TNCs from one ...
Transfusion-associated graft versus host disease frequently occurs in immunodeficient patients where recipient's body failed to ... Immunologic reaction[edit]. *Acute hemolytic reactions are defined according to Serious Hazards of Transfusion (SHOT) as "fever ... Kopolovic, Ilana; Tsubota, Hideki (2015). "A systematic review of transfusion-associated graft-versus-host disease". Blood. 126 ... Febrile nonhemolytic reactions are, along with allergic transfusion reactions, the most common type of blood transfusion ...
... a graft-versus-host reaction occurred; this was known as the Simonsen phenomenon. Their work in this system would later help to ... Burnet was involved in work relating to autoimmune diseases and the graft-versus-host reaction, and increasingly in theoretical ... Burnet's work on graft-versus-host was in collaboration with Lone Simonsen between 1960 and 1962. Simonsen had shown in 1957 ... He conducted research into the agglutinin reactions in typhoid fever, leading to his first scientific publications. He decided ...
The role of pattern-recognition receptors in graft-versus-host disease and graft-versus-leukemia after allogeneic stem cell ... Mechanisms of the graft-versus-leukemia reaction. „Stem Cells". 15 (4), s. 248-58, 1997. DOI: 10.1002/stem.150248. PMID: ... Jednocześnie dochodzi do rozwoju niekorzystnej reakcji przeszczep przeciw gospodarzowi (graft-versus-host disease, GvHD). ...
In addition, he foresaw the concept of graft-versus-host responses. Despite these research results, clinical application ... who also believed that immunological reactions explained graft rejection. Dempster and his associates demonstrated that ... irradiating the whole body could suppress delayed type hypersensitivity reactions and the response to skin allografts. This ...
"Active suppression of host-vs-graft reaction in pregnant mice. VII. Spontaneous abortion of allogeneic CBA/J x DBA/2 fetuses in ...
... those at risk of transfusion-associated graft versus host disease). Hillyer CD (2007). Blood Banking and Transfusion Medicine: ... Side effects can include allergic reactions such as anaphylaxis, infection, and lung injury. Bacterial infections are ... Side effects can include allergic reactions such as anaphylaxis, infection, and lung injury. Bacterial infections are ... which decreases the risk of having a transfusion reaction. They can be treated with ultraviolet light which decreases the risk ...
Graft-versus-host disease[edit]. Main article: Graft-versus-host disease. Graft-versus-host disease (GVHD) is an inflammatory ... This is due to a therapeutic immune reaction of the grafted donor T lymphocytes against the diseased bone marrow of the ... Graft-versus-tumor effect (GVT) or "graft versus leukemia" effect is the beneficial aspect of the Graft-versus-Host phenomenon ... Graft-versus-host disease is usually mediated by T cells, which react to foreign peptides presented on the MHC of the host.[ ...
Graft versus host disease is an auto- and alloimmune disorder, exhibiting a variable clinical course. It can manifest in either ... Surgical implantation of a biomaterial into the body triggers an organism-inflammatory reaction with the associated healing of ... Velnar, Tomaz; Bunc, Gorazd; Klobucar, Robert; Gradisnik, Lidija (2016). "Biomaterials and host versus graft response: a short ... These include immune response, foreign body reaction with the isolation of the implant with a vascular connective tissue, ...
Graft-versus-host disease (GVHD) is a major barrier for allogeneic stem cell transplant because of the immune reactions of ... Thus, cyclophosphamide preconditioning of recipient hosts (for donor T cells) has been used to enhance immunity in naïve hosts ... GVHD can often be avoided by T-cell depletion of the graft. The use of a high dose cyclophosphamide post-transplant in a half ... Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced ...
... as a results of host-against-self reaction, where immune cells initiate tissue-specific destruction. Similarly, allografting ... results in a strong immune response, which clinically necessitates a continued immunosuppression to maintain graft survival. ... December 2018). "Cytolytic Activity (CYT) Score Is a Prognostic Biomarker Reflecting Host Immune Status in Hepatocellular ... proving the importance of immune reaction in breast cancer. It was also shown that ICR classification is dependent upon ...
Bone marrow transplants require a complete match on six key antigens, which are measures of graft-versus-host reaction, known ... The high relapse rates after autologous or syngeneic transplant and the benefit of a graft-vs.-leukemia effect of an allogeneic ...
If the donor white blood cells are not irradiated, the recipient may be at risk of developing graft-versus-host disease. ... which can predispose them to transfusion reactions, decrease the lifespan of donor white blood cells in their circulation, and ... which can cause graft-versus-host disease in the recipient, so it is often exposed to radiation to inactivate these cells.:628 ... because antibodies against donor granulocytes can reduce the effectiveness of the transfusion and cause transfusion reactions.: ...
Lichen verrucosus et reticularis Lichenoid trikeratosis Lichenoid dermatitis Lichenoid reaction of graft-versus-host disease ... contact lichenoid reaction, lichenoid amalgam reaction, oral mucosal cinnamon reaction) Contact urticaria Corticosteroid- ... Graft-versus-host disease Griscelli syndrome Hyper-IgE syndrome (Buckley syndrome, Job syndrome) Immunodeficiency with hyper- ... drug reaction Halogenoderma Heparin necrosis HIV disease-related drug reaction Hydroxyurea dermopathy Injection site reaction ...
... differential hosts, peroxidase isozymes and activity, total RNA content and Reserves Transcription-Polymerase Chain Reaction ( ... CPsV-EG was detected on the basis of biological indexing by graft inoculation which gave oak leaf pattern (OLP) on Dweet tangor ... CPsV-EG was reacted with variable responses on 16 host plants belonging to 6 families. Only 8 host plants are susceptible and ... CPsV-EG isolate was transmitted from infected citrus to citrus by syringe and grafting and herbaceous plants by forefinger ...
... with significant mortality risks and potential for life-threatening or altering complications such as graft-versus-host disease ... The human body depends on a vast array of biochemical reactions to support critical functions, including the production of ... For a long time, the most efficient approach had been to use bone marrow graft, or hematopoietic stem cell transplantation. ... Because of all these reasons, bone marrow grafts or hematopoietic stem cell transplantation have seen a decrease in their ...
... supplying a substrate for that enzyme can catalyze a reaction whose product can be detected by luminescence or by absorbance. ... Transfusion-associated graft versus host disease. Unknown/. multiple. Foreign. *Hypersensitivity pneumonitis *Allergic ...
Orphan indications by the FDA include graft-versus-host disease, mycobacterial infection, recurrent aphthous ulcers, severe ... Scheme 2 is the newer synthesis route which was designed to make the reaction more direct and to produce better yields. This ... The downside of this process however is that the last step requires a high-temperature melt reaction which demands multiple ... Adverse reactions include peripheral neuropathy in large majority of patients, constipation, thromboembolism along with ...
The reaction is usually seen 2-24 hours after the original reaction.[41] Cytokines from mast cells may also play a role in the ... Transfusion-associated graft versus host disease. Unknown/. multiple. Foreign. *Hypersensitivity pneumonitis *Allergic ... Skin tests cannot predict if a reaction would occur or what kind of reaction might occur if a person ingests that particular ... chickpeas and fish has been well documented as triggering reactions, including anaphylactic reactions.[62][64] One review ...
Graft-versus-host disease[5]. *Chronic transplant rejection. See also[edit]. *Type I hypersensitivity ... "Hypersensitivity reactions". Retrieved 2016-05-29.. *^ McDonough, K.; Kress, Y.; Bloom, B. R. (July ... Tuberculin reaction (Mantoux test)[3]. Tuberculin. Induration and erythema around injection site indicates previous exposure. ... Type 4 hypersensitivity is often called delayed type hypersensitivity as the reaction takes several days to develop. Unlike the ...
Gum graft. *Head and neck anatomy. *Periodontitis. ReferencesEdit. *^ Gum disease opens up the body to a host of infections ... Reaction to disturbanceEdit. Healthy gums usually have no reaction to normal disturbance such as brushing or periodontal ...
Mitra A, Dwyre DM, Schivo M, Thompson GR, Cohen SH, Ku N, Graff JP (Mart 2020). "Leukoerythroblastic reaction in a patient with ... Diamond (13 Mayıs 2020). "The challenges of vaccine development against a new virus during a pandemic". Cell Host and Microbe. ... "Evolutionary history, potential intermediate animal host, and cross‐species analyses of SARS‐CoV‐2". Journal of Medical ...
... a graft-versus-host-like disease". J Am Acad Dermatol. 57 (4): 683-9. doi:10.1016/j.jaad.2007.02.027. PMID 17433850. Kumar, ... Sometimes an allergen may cause a sudden and severe, possibly fatal reaction in a sensitive individual; this is called ... Autoimmune diseases are caused by a hyperactive immune system that instead of attacking pathogens reacts against the host ... It effectively protects the host from various infections. An improperly functioning immune system can cause discomfort, disease ...
... evidence that autoimmunity can arise as a result of a cross-reaction between the idiotype on an antiviral antibody and a host ... Idiotype Cross-Reaction - Idiotypes are antigenic epitopes found in the antigen-binding portion (Fab) of the immunoglobulin ... Epitope spreading or epitope drift - when the immune reaction changes from targeting the primary epitope to also targeting ... In this case, the host-cell receptor is envisioned as an internal image of the virus, and the anti-idiotype antibodies can ...
Radiation recall reaction. Radiation-induced erythema multiforme. Radiation-induced hypertrophic scar. Radiation-induced keloid ... Transfusion-associated graft versus host disease. Unknown/. multiple. Foreign. Hypersensitivity pneumonitis (Allergic ... "AAAAI - stinging insect, allergic reaction to bug bite, treatment for insect bite". Retrieved 2007-12-03.. ... "AAAAI - skin condition, itchy skin, bumps, red irritated skin, allergic reaction, treating skin condition". Retrieved 2007-12- ...
Graft-versus-host disease. *v. *t. *e. Drug reactions (Y40-Y59, E930-E949) ... Febrile non-hemolytic transfusion reaction is a type of transfusion reaction that is associated with fever but not directly ... "Pathophysiology of febrile nonhemolytic transfusion reactions". Curr. Opin. Hematol. 6 (6): 420-6. doi:10.1097/00062752- ... "The effect of prestorage WBC reduction on the rates of febrile nonhemolytic transfusion reactions to platelet concentrates and ...
Such reactions account for a significant proportion of perioperative anaphylactic reaction, especially in children with ... Transfusion-associated graft versus host disease. Unknown/. multiple. Foreign. *Hypersensitivity pneumonitis *Allergic ... Type I hypersensitivity can cause an immediate and potentially life-threatening reaction, not unlike the severe reaction some ... Latex allergy is a medical term encompassing a range of allergic reactions to the proteins present in natural rubber latex.[1] ...
Practices of microtransplantation has shown none graft-versus-host disease (GVHD) till present, thus immunosuppressive drugs ... To overcome the intolerable severe reactions of high-dose chemotherapy and GVHD, as well as the challenge to find HLA-matched ... No graft-versus-host disease was observed in any patient. Persistent donor microchimerism was successfully detected in all of ... graft-versus-tumor (GVT) effect. Donor's stem cells, which have been processed, will also accelerate functional recovery of ...
Delayed graft function, complications of kidney transplant I, II Recruiting Quark Pharmaceuticals NCT00802347 ... Some viruses have evolved mechanisms for suppressing the RNAi response in their host cells, particularly for plant viruses.[81] ... Mouse oocytes and cells from early mouse embryos lack this reaction to exogenous dsRNA and are therefore a common model system ... The other strategy is to block the initial viral entries by targeting the host cell genes.[152] For example, suppression of ...
"Factbox-World reaction to Egypt's Mubarak quitting in September". Reuters. 3 February 2011. Retrieved 3 February 2011.. ... "Egypt's Mubarak gets three years in a graft case". Middle East Star. Retrieved 22 May 2014.. ... In October 2000, Mubarak hosted an emergency summit meeting at Sharm el-Sheikh to discuss the Israeli-Palestinian conflict. In ... Mubarak, on occasion also hosted meetings relating to the Israeli-Palestinian conflict and made a number of attempts to serve ...
Thus, cyclophosphamide preconditioning of recipient hosts (for donor T cells) has been used to enhance immunity in naïve hosts ... Enhanced grafting of adoptively transferred, tumor-reactive effector T cells by the creation of an immunologic space niche. ... Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced ... Elimination of T regulatory cells (CD4+CD25+ T cells) in naive and tumor-bearing hosts ...
Past Christmas Lectures are hosted on the Ri's website and in early 2018 the Ri began a to upload all past Christmas Lectures ... George, Baron Porter of Luddenham (1920-2002) - Chemistry 1967 for work on chemical reactions triggered by light, and for ... Peter Brian Medawar (1915-1987) - Medicine 1960 for his work on making permanent skin grafts ... In May 2015, The Royal Institution was host to the historic unveiling of the Santara Computer, created by Dr Andrew Deonarine.[ ...
CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. „J Exp Med". 196 (3), s. 401-406, ... CD4+ CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed ... immunoregulatory T cells for the control of graft-versus-host disease after allogeneic hematopoietic stem-cell transplantation ... CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 ...
Antigens of phagocytosed graft cells can also be presented by the host's class I MHC molecules to CD8+ T cells.[1][29] ... Fibrosis in the xenograft occurs as a result of immune reactions, cytokines (which stimulate fibroblasts), or healing ( ... The graft was meant to be temporary, but unfortunately a suitable allograft replacement could not be found in time. While the ... The graft is given a break from humoral rejection[28] when the complement cascade is interrupted, circulating antibodies are ...
Heirloom gardening is a reaction against this trend. In the Global South, heirloom plants are still widely grown, for example, ... hosted by a town library, allowed gardeners to "check out" a package of open-pollinated seed, and "return" seeds kept from the ... while fruit varieties such as apples have been propagated over the centuries through grafts and cuttings. The trend of growing ...
Transfusion Reactions[edit]. Once a woman has antibodies, she is at high risk for a future transfusion reaction if she is in ... Transfusion-associated graft versus host disease. Unknown/. multiple. Foreign. *Hypersensitivity pneumonitis *Allergic ... and relatively mild clinical reactions. Acute hemolytic transfusion reactions due to immune hemolysis may occur in patients who ... Immune-mediated hemolytic reactions caused by IgG, Rh, Kell, Duffy, or other non-ABO antibodies typically result in ...
Among his advances was the tubed pedicle graft, which maintained a flesh connection from the donor site until the graft ... Identifying the immune reactions in 1951, Medawar suggested that immunosuppressive drugs could be used. Cortisone had been ... Len O, Garzoni C, Lumbreras C, Molina I, Meije Y, Pahissa A, Grossi P; The ESCMID Study Group of Infection in Compromised Hosts ... Graft survival and people's mortality is approximately the same between ABOi and ABO-compatible (ABOc) recipients.[18] While ...
"Host-versus-graft disease" redirects here. For the condition in which transplanted cells attack the recipient's cells, see ... There is a risk of graft-versus-host disease (GVHD), however, whereby mature lymphocytes entering with marrow recognize the new ... Graft survival and patient mortality is approximately the same between ABOi and ABO-compatible (ABOc) recipients.[4] While ... When the paratope of Ig class gamma (IgG) binds its matching epitope, IgG's Fc region conformationally shifts and can host a ...
Drug reactions. Drug-induced lupus erythematosus is a (generally) reversible condition that usually occurs in people being ... Transfusion-associated graft versus host disease. Unknown/. multiple. Foreign. *Hypersensitivity pneumonitis *Allergic ... These stimuli begin a reaction that leads to destruction of other cells in the body and exposure of their DNA, histones, and ... "University of South Carolina School of Medicine lecture notes, Immunology, Hypersensitivity reactions. General discussion of ...
Although rare, (about 0.08 reported reactions per million doses of tuberculin), these reactions can be dangerous and ... Transfusion-associated graft versus host disease. Unknown/. multiple. Foreign. *Hypersensitivity pneumonitis *Allergic ... Classification of tuberculin reaction[edit]. The results of this test must be interpreted carefully. The person's medical risk ... Thus, a positive reaction to a subsequent test may be misinterpreted as a new infection, when in fact it is the result of the ...
... which requires that all T cells be removed before infusion into the patients to remove the risk of graft versus host disease, ... allowing for a much faster immune reaction. They were named "natural killers" because of the initial notion that they do not ... and in models of hapten-hypersensitivity reactions. Especially, in the MCMV model, protective memory functions of MCMV-induced ...
Interfere with host defences: Destroy host tissues: Inhibit host repair of tissues: ... Regenerative surgical therapy currently available include the use of bone replacement grafts, barrier membranes or guided ... and inflammatory stimuli with very high levels of local release inflammatory mediators and induce hyper-inflammatory reaction ... Virulence factors are the attributes of microorganisms that enable it to colonise a particular niche in its host, overcome the ...
Lichenoid reaction of graft-versus-host disease. *v. *t. *e. Diseases of joints (M00-M19, 711-719) ...
Graft-versus-host disease (GVHD) is the major complication after allogeneic hemopoietic stem cell transplantation. GVHD is ... Cytokines in Graft-Versus-Host Disease and the Graft-Versus-Leukemia Reaction. ... The immune system: effector and target of graft-versus-host disease. In: Ferrara JLM, Deeg HJ, Burakoff SJ, eds. Graft-vs.-Host ... The role of cytokines in graft-versus-host reactions and disease.Bone Marrow Transplant. 1992;10:1-14.PubMedGoogle Scholar ...
Graft-vs-Host Reaction Induced by Para-aortic Lymph Nodes During Estrous and Diestrous Stages. Authors. *. YOLANDA P. DE ... or soluble factors released by them in both phases of the estrous cycle were examined in the graft-vs-host (GVH) assay. The ... Next article in issue: Skin Graft Survival in the Uterine Lumen of Ewes Treated With Progesterone Next article in issue: Skin ...
... cutaneous graft versus host reaction explanation free. What is cutaneous graft versus host reaction? Meaning of cutaneous graft ... versus host reaction medical term. What does cutaneous graft versus host reaction mean? ... Looking for online definition of cutaneous graft versus host reaction in the Medical Dictionary? ... cutaneous graft versus host reaction. Also found in: Acronyms. cu·ta·ne·ous graft ver·sus host re·ac·tion. an acute ...
Baca-Trespalacios, Maria Eugenia (1987) Lymphoid effector cells in intestinal graft-versus-host reaction. PhD thesis, ... are involved in intestinal cell-mediated immune responses as exemplified by the intestinal phase of graft-verus-host reaction ( ... However beige spleen cells were as efficient as B6 cells in inducing a lethal GyHR in irradiated hosts. Although these results ... The fact that donor cells require to an host lymphoid tissue in order to mediate alloreactive immune responses led me to ...
Separate effects of irradiation and of graft-versus-host reaction on rat mucosal mast cells. ... Separate effects of irradiation and of graft-versus-host reaction on rat mucosal mast cells. ... to the mechanisms of this enteropathy by using graft-versus-host reaction (GvHR) in the rat as a model of mucosal delayed type ...
Local graft versus host reactions within the anterior chamber of the eye: the formation of corneal endothelial pocks. ... Local graft versus host reactions within the anterior chamber of the eye: the formation of corneal endothelial pocks. ... A A Khodadoust, A M Silverstein; Local graft versus host reactions within the anterior chamber of the eye: the formation of ... to the histocompatibility antigens of the recipient leads to the development of an intraocular graft versus host reaction. This ...
1 What is a graft-versus-host disease (reaction). 2 When and why does it occur. 3 What is the spectrum of its cutaneous ... Santos GW, Hess AD, Vogelsang GB (1985) Graft-versus host reactions and disease. Immunol Rev 88:169-192.PubMedCrossRefGoogle ... Saurat J.H. (1988) Graft-Versus-Host Reaction in the Skin: Why Is It Important for the Dermatologist. In: Orfanos C.E., Stadler ... Saurat JH (1984) Graft versus host reaction. In: MacKie RM (ed) Current perspectives in immunodermatology. Churchill ...
... Naude, P.J.W. (Petrus Johan ... Potassium humate inhibits carrageenan induced paw oedema and a graft-vs-host reaction in rats. Login ... a carrageenan-induced inflammation model and an allogeneic graft-versus-host reaction (GVHR) in rats were investigated. Paw ... The effects of potassium humate, at an oral dose of 60 mg/kg bodyweight, on a delayed type hypersensitivity reaction, ...
Fatal graft-vs.-host reaction following transfusion of allogeneic blood and plasma in infants with combined immunodeficiency ... Fatal Graft-versus-Host reaction following granulocyte transfusions. *Waltraud Schmidmeier, Wolfgang Feil, +7 authors Ernst ... Fatal graft-vs.-host reaction following transfusion of allogeneic blood and plasma in infants with combined immunodeficiency ... Graft-versus-host reaction after blood transfusion in a patient with cellular immunodeficiency: The role of histocompatibility ...
What is graft versus host reaction? Meaning of graft versus host reaction medical term. What does graft versus host reaction ... Looking for online definition of graft versus host reaction in the Medical Dictionary? graft versus host reaction explanation ... graft versus host reaction. graft ver·sus host re·ac·tion (GVHR), clinical and histologic changes of graft versus host disease ... Graft versus host reactions. In: Rook A, Savin J, editors.. Clinical aspects of sclerodermatous type graft-versus-host disease ...
2006MO46 Graft Vs Host reaction (GVH) When the graft is mounted on the host, an immune response against the antigens of the ... Graft Vs Host reaction (GVH). When the graft is mounted on the host, an immune response against the antigens of the host is ... Graft Vs Host reaction (GVH). sudheerkher on Fri Nov 14, 2008 1:27 am ... The recipient must not reject the graft.. Major clinical features of the GVH reaction in animal are:. Retardation of growth. ...
Graft-versus-host disease. Graft-versus-host (GVH) disease occurs when donor lymphocytes mount an immune response against the ... Nonhemolytic febrile reactions and minor allergic reactions are the most common transfusion reactions, each occurring in 3-4% ... Transfusion-associated graft versus host disease is associated with an 80-90% mortality rate. ... 2] Rates of specific reactions are as follows:. * Hemolytic transfusion reactions occur in one per 40,000 transfused units of ...
... occurs when donor cells recognize the host cells as foreign and begin to attack it. Symptoms can be mild, severe or even fatal. ... What are the Symptoms and Signs of Graft versus Host Disease?. The reactions to GvHD range from mild, severe to life- ... How do you Treat Graft versus Host Disease?. Acute graft versus host disease is graded on a scale of 0 to IV depending on the ... Novel Treatment to Prevent Graft-Versus-Host-Disease. Graft-versus-host-disease (GVHD) is the leading cause of non-relapse ...
MAT.; BONE MARROW CELLS; TRANSPLANTS; LYMPHOCYTES; BIOLOGICAL FUNCTIONS; GRAFT-HOST REACTION; LECTINS; MICE; RADIATION CHIMERAS ... Title: Enhancement of bone marrow allografts from nude mice into mismatched recipients by T cells void of graft-versus-host ... Enhancement of bone marrow allografts from nude mice into mismatched recipients by T cells void of graft-versus-host activity ... after conditioning with 8 Gy of total body irradiation has resulted in a markedly higher rate of graft rejection or graft ...
Morphological manifestations and morphogenesis of the graft vs. host reaction in the brain of F1 hybrids following the ... Participation of phytohemagglutinin-transformed mouse lymphocytes in development of the graft-versus-host reaction. (opens in ...
Mixed Lymphocyte Reaction(MLR). *Adverse effects related to infusion. Secondary Outcome Measures : *Complete, Partial Response ... Graft-Versus-Host Disease GVHD Allogeneic Hematopoietic Transplant Disorder Related to Transplantation Biological: Human ... Graft-Versus-Host Disease. GVHD. Hematopoietic Stem Cell Transplantation. Stem Cell Transplantation. Allogeneic hematopoietic ... Graft-versus-host-disease (GVHD) is a major complication following allogeneic hematopoietic stem cell transplantation (allo- ...
... and complications include allergic reactions, infections, and lung injuries. The type of blood transfusion depends on the ... Graft-Versus-Host disease. Graft-versus-host disease (GVHD) is a condition in which white blood cells in the new blood attack ... Acute immune hemolytic reaction. Acute immune hemolytic reaction is very serious, but also very rare. It occurs if the blood ... Allergic Reactions. Some people have allergic reactions to the blood given during transfusions. This can happen even when the ...
A graft-versus-host reaction was induced in New Zealand Black X New Zealand White F1 hybrid mice by administration of New ... Increased survival times of new-zealand hybrid mice immunosuppressed by graft versus host reactions Academic Article ... were more immunosuppressed than mice with graft-versus-host reactions and had even greater survival times. ...
Billingham, R.E. (1966). "The biology of graft-versus-host-reactions". Harvey Lectures. 1966-1967 (62): 21-78. PMID 4875305.. ... Hale, G; Waldmann, H (1994). "Control of graft-versus-host disease and graft rejection by T cell depletion of donor and ... A wide range of host antigens can initiate graft-versus-host-disease, among them the human leukocyte antigens (HLA)[18]. ... search of for Graft-versus-host disease *^ "Worlds First Stem-Cell Drug Approval Achieved in Canada". The ...
graft vs host reaction ڐA БΏh 唽 AGVHR graft-versus-host disease ڐA БΏh a AGVHD ...
Suppressive influence of surgical stress on the graft-versus-host reaction in mice. (opens in new tab) ... Kinetics of thymus-derived lymphocyte count changes in rats affected by graft-versus-host reaction. Neoplasma ... Intrahepatic lymphoid tissue graft: course of the Gvh reaction induced by Peyers patches. (opens in new tab) ... of T lymphocytes from the spleen and lymph nodes into the circulation already in the very first days of the reaction might be ...
Effect of host-versus-graft and graft-versus-host reactions on the immune response of mice to sheep red blood cells. ... Zaleski, M, "Effect of host-versus-graft and graft-versus-host reactions on the immune response of mice to sheep red blood ...
Studies on graft versus host (GvH) reactions. I. Impairment of hemopoietic stroma in mice suffering from GvH disease. Exp ... The biology of graft-versus-host reactions. Harvey Lect 1966;62:21-78. *PubMed ... Involvement of Fas-mediated apoptosis in the hematopoietic progenitor cells of graft-versus-host reaction-associated ... Effect of graft-versus-host disease (GVHD) on host hematopoietic progenitor cells is mediated by Fas-Fas ligand interactions ...
Donor mesenchymal stem cell infusion may be an effective treatment for acute or chronic graft-versus-host diseas... ... Graft Vs Host Reaction. An immunological attack mounted by a graft against the host because of tissue incompatibility when ... Sclerodermatous graft-versus-host disease is a subtype of cutaneous chronic graft-versus-host disease that is characterized by ... chronic graft-versus-host disease. Chronic graft-versus-host disease is a complication of a donor bon... ...
... to establish a new scoring system for predication of delayed graft funct... ... Graft Vs Host Reaction. An immunological attack mounted by a graft against the host because of tissue incompatibility when ... The immune responses of a host to a graft. A specific response is GRAFT REJECTION. ... The use of machine perfusion (MP) in kidney transplantation lowers delayed graft function (DGF) and improves 1-year graft ...
Chronic graft-versus-host disease (GVHD) still remains the most significant complication after allogeneic hematopoietic stem ... Preferential activation of Th2 cells in chronic graft-versus-host reaction. J Immunol. 1993;150:361-366.PubMedPubMedCentral ... Gleichmann E, Pals ST, Rolink AG, Radaszkiewicz T, Gleichmann H. Graft-versus-host reactions: clues to the etiopathology of a ... Persistence of host dendritic cells after transplantation is associated with graft-versus-host disease. Biol Blood Marrow ...
GVHR graft-versus-host reaction. GYN gynecology. HA headache. HAA hepatitis-associated antigen ...
GVHR graft-versus-host reaction. GYN gynecology. HA headache. HAA hepatitis-associated antigen ... Place I (a) Adverse reaction to drugs and ethanol T509 &Y14 T510 Y15. 0 ...
We examined the molecular pathogenesis of graft-versus-host disease-associated (GVHD-associated) liver injury in mice, focusing ... Reverse Transcriptase Polymerase Chain Reaction * T-Lymphocytes, Cytotoxic / immunology* Substances * Antibodies, Monoclonal ... Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease J Clin ... We examined the molecular pathogenesis of graft-versus-host disease-associated (GVHD-associated) liver injury in mice, focusing ...
  • Graft-versus-host disease (GVHD) is the major complication after allogeneic hemopoietic stem cell transplantation. (
  • There are now compelling data on the role of host tissue destruction as the initial insult, extensive interactions of cellular donor and host components, a complex network of cytokines, adhesion molecules, and other components in the development of GVHD. (
  • Application of the principles of cytokine signaling to the clinical setting may necessitate new trial design structures that take into consideration donor and host characteristics as well as the kinetics of GVHD development. (
  • GvHD occurs when lymphocytes (immune cells) in the donor tissue encounter antigens of the host tissue, which are seen as foreign, resulting in undesirable manifestations in the host. (
  • The risk of GvHD is reduced (30% to 40%) when there is increased similarity in the cells and tissues between the donor and the host. (
  • The risk of GvHD is higher (60% to 80%) when the donor is unrelated to the host. (
  • Sometimes, the reaction may be due to a prior acute GvHD (aGVHD). (
  • Cases of acute GvHD (aGVHD) appear in the host, usually within 100 days. (
  • In acute GvHD, there is a mismatch between the donor and the host in relation to the human leukocyte antigen (HLA). (
  • The reactions to GvHD range from mild, severe to life-threatening. (
  • Graft-versus-host-disease (GVHD) is a major complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT) which may cause acute life-threatening morbidity or chronic disabilities. (
  • Graft-versus-host disease ( GvHD ) is a medical complication following the receipt of transplanted tissue from a genetically different person . (
  • Graft versus host disease (GvHD) remains a major complication after allogeneic hematopoietic stem cell transplantation and is the main cause of transplant-related mortality. (
  • Besides infection, graft versus host disease (GvHD) remains the main cause of morbidity and mortality after allogeneic HSCT. (
  • GvHD is mediated by alloreactive donor lymphocytes that reside in the graft and target nonmalignant host tissues. (
  • Determine the safety of donor mesenchymal stem cell (MSC) infusion in patients with acute or extensive chronic graft-vs-host disease (GVHD) after undergoing HLA-identical sibling donor stem cell transplant. (
  • We examined the molecular pathogenesis of graft-versus-host disease-associated (GVHD-associated) liver injury in mice, focusing on the role of chemokines. (
  • The aim of the current study was to evaluate the effects and putative mechanism of action of evasin-1, a novel CCL3-binding protein, in the pathogenesis of acute graft-versus-host disease (GVHD). (
  • Altogether, our studies demonstrate that CCL3 plays a major role in mediating GVHD, but not graft-versus-leukemia in mice and suggest that blockade of CCL3 with evasin-1 has potential therapeutic application in patients undergoing bone marrow transplantation. (
  • Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT), leading to significant morbidity and mortality in humans ( 1 ). (
  • However, up to 40% of HSCT patients will develop graft-versus-host disease (GvHD) in either an acute or a chronic form ( 2 ). (
  • Acute GvHD (aGvHD) is a serious complication of HSCT and occurs when T cells in the graft elicit an immune response against the host, causing tissue damage in the skin, liver, and gastrointestinal tract ( 2 ). (
  • Graft-versus-host disease (GvHD) is a major cause of morbidity and mortality in hematopoietic stem cell transplantation (HSCT). (
  • The transfusion reactions are classified into anaphylactic reaction, bacterial infection, acute hemolytic reaction, febrile non-hemolytic reaction, transfusion-related acute lung injury TRALI , transfusion-associated circulatory overload , transfusion-associated microchimerism (TA-MC), iron overload, and transfusion-associated Graft-versus-Host Disease (GvHD). (
  • Current consensus is that clinical manifestations guide whether the signs and symptoms of graft-versus-host disease (GVHD) are acute, chronic, or an overlap syndrome. (
  • Graft-versus-host disease (GVHD) is a major complication following allogeneic haematopoietic cell transplantation (HCT) and occurs when donor T cells respond to histoincompatible antigens on the host tissues. (
  • Four groups were investigated in detail: recipients of non--T-cell depleted allografts without graft-versus-host disease (GVHD), recipients of non--T-cell depleted allografts with GVHD, recipients of T-cell depleted allografts, and recipients of genetically identical twin transplants. (
  • These data support an antileukemia effect of allogeneic grafts independent of GVHD. (
  • 1. Management of acute graft-versus-host disease Andrea Bacigalupo Divisione Ematologia e Trapianto di Midollo, Ospedale San Martino, Genova, Italy Summary Acute graft-versus-host disease (GvHD) is a frequent compli- cation of allogeneic haemopoietic stem cell transplantation (HSCT) and donor lymphocyte infusions (DLI). (
  • To date, GvHD has not been differentiated from the graft-versus-leukaemia effect. (
  • Although the pathogenesis of graft-versus-host disease (GvHD) is not the aim of the present review, a few words are warranted: indeed some of the recent advances in understanding cellular and cytokine mechanisms leading to GvHD have been useful in the clinic. (
  • GvHD is thought to be caused by donor T cells reacting against host allo-antigens: this may well be the case, but the mechanism underlying such immune reaction are quite complex (Teshima & Ferrara, 2002a). (
  • Therefore host APC participate in activating donor T cells to kill host cells and the age of host APC seems relevant (in keeping with the notion that older patients have more GvHD) (Ordemann et al, 2002). (
  • Graft vs. Host Disease (GvHD) is a reaction that develops after an allogeneic bone marrow transplant. (
  • In this study, we examined CD28-B7-independent activation pathways in the pathogenesis of graft-vs-host disease (GVHD) using allogeneic T cells from CD28-deficient mice. (
  • In contrast, treatment with anti-CD80 plus anti-CD86 mAbs exacerbated the clinical manifestations of GVHD and increased the T cell response against host alloantigen, resulting in the expression of CTLA4, CD40L, and CD25 on splenic T cells. (
  • Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. (
  • This study will explore the role of a bacterial toxin (endotoxin), which normally resides in the intestine but enters the bloodstream as a consequence of chemo- and radio-therapy in patients with leukemia or lymphoma undergoing bone marrow transplantation, in initiating Graft-versus-Host Disease (GVHD) in transplant recipients. (
  • These transplants are often lifesaving, but they frequently result in severe and sometimes deadly GVHD, in which donor immune T cells (white blood cells) recognize host tissues as foreign and mount an inflammatory attack against the patients' tissues. (
  • As a part of these immune based strategies, Dr. Matsui has a clinical interest in bone marrow transplantation, and has been actively expanding its use in multiple myeloma by focusing on the development of strategies to reduce the rates of graft versus host disease (GVHD), a major complication of allogeneic bone marrow transplantation (alloBMT). (
  • Graft-versus-host disease (GVHD) is a serious complication of allogeneic stem-cell transplant, in which the transplanted cells or bone marrow attack the recipient's body. (
  • The main complication of AHSCT is the development of graft versus host disease (GVHD). (
  • We tested the hypothesis that oral beclomethasone dipropionate (BDP) would control gastrointestinal graft-versus-host disease (GVHD) in patients with anorexia, vomiting, and diarrhea. (
  • Gastrointestinal graft-versus-host disease (GVHD) affects up to 60% of patients after allogeneic hematopoietic cell transplantation. (
  • This reaction, known as graft-versus-host disease (GVHD), can be lethal if it continues unchecked. (
  • The beneficial GVT effect after allogeneic bone marrow transplantation (BMT) is tightly linked to its most significant complication, graft-versus-host disease (GVHD). (
  • Its applicability has been limited by its major complication, graft-versus-host disease (GVHD). (
  • Several inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) are elevated after allogeneic BMT and known to perpetuate GVHD through either direct cytotoxic effects on host tissues ( 6 ) or by activation and/or priming of immune effector cells ( 7 ). (
  • In rare cases, patients develop graft-versus-host disease (GVHD) after a transfusion of a blood product. (
  • Graft versus host disease (GVHD) has traditionally been divided into acute GVHD and chronic GVHD based on the period it occurs after transplantation. (
  • Graft versus host disease (GVHD) is a frequent complication that occurs in 23% to 80% of the patients who undergo allogenic bone marrow transplantation 1 . (
  • The optimal dose of rabbit antithymocyte globulin (ATG, ImtixSangstat) minimizing infections without increasing graft-versus-host disease (GVHD) is unknown in T cell-replete, G-CSF-primed haploidentical hematopoietic stem cell transplantation (haplo-HSCT). (
  • Currently, the strategies for graft-versus-host disease (GVHD) prophylaxis mainly include ex vivo and in vivo T cell depletion (TCD) in haploidentical HSCT (haplo-HSCT) [ 4 , 5 ]. (
  • This reduces the need for intensive pretreatment and the chance of rejection and graft versus host disease (GVHD, learn more) is much lower. (
  • She is hospitalized and treated with cyclosporine and methylprednisolone for 10 days until the graft versus host disease (GVHD) is controlled. (
  • Graft rejection and graft-versus-host disease (GVHD) are the major immune-mediated complications associated with HLA disparity. (
  • Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients. (
  • BACKGROUND: Proper histomorphological interpretation of intestinal acute graft versus host disease (A-GVHD) associated with allogeneic bone marrow transplantation (BMT) is critical for clinical management. (
  • 2007 ). However, the major toxicity of allogeneic HCT, Graft-Versus-Host disease (GVHD), remains a lethal complication that limits its wider application (Ferrara and Reddy, 2006 ). (
  • The GVHD reaction was first noted when irradiated mice were infused with allogeneic marrow and spleen cells (van Bekkum and De Vries, 1967 ). (
  • In addition to these seminal postulates on GVH reaction, the critical requirement of immune cells from the donor graft for optimal leukemia/tumor elimination: a process called graft-versus-leukemia (GVL) effect, and its tight link with GVHD were initially made from mouse models (43). (
  • Pathophysiologic mechanisms of acute graft-vs.-host disease [review]. (
  • Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia. (
  • Delaying transplantation after total body irradiation is a simple and effective way to reduce acute graft-versus-host disease mortality after major H2 incompatible transplantation. (
  • Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. (
  • The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation [review]. (
  • Prevention of graft versus host disease by inactivation of host antigen-presenting cells. (
  • Differential effects of anti-Fas ligand and anti-tumor necrosis factor alpha antibodies on acute graft-versus-host disease pathologies. (
  • Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function. (
  • Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. (
  • Analysis of Fas system in pulmonary injury of graft-versus-host disease after rat intestinal transplantation. (
  • Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease. (
  • Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28. (
  • Tsukada N, Akiba H, Kobata T, Aizawa Y, Yagita H, Okumura K. Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation. (
  • What is a graft-versus-host disease (reaction). (
  • Sale GE (1984) Human graft-versus-host disease. (
  • Santos GW, Hess AD, Vogelsang GB (1985) Graft-versus host reactions and disease. (
  • Elliott CJ, Sloane JP, Sanderson KV, Vincent M, Shepherd V, Powles R (1987) The histological diagnosis of cutaneous graft versus host disease: relationship of skin changes to marrow purging and other clinical variables. (
  • Graham-Brown RAC, Jones JAG, Shaw PV, Barnett DB (1987) A graft-versus-host disease-like syndrome. (
  • 1983) Syndrome resembling graft-versus-host disease in a patient with disseminated carcinoma. (
  • Atkinson K, Weiler P, Ryman W, Biggs J (1986) PUVA therapy for drug-resistant graft-versus-host disease. (
  • Vogelsang GB, Hess AD, Gordon G, Santos GW (1986) Treatment and prevention of acute graft-versus-host disease with Thalidomide in a rat model. (
  • Treatment of skin ulcers in chronic graft-versus-host disease with skin grafts from the bone marrow donor. (
  • Fatal graft-vs.-host reaction following transfusion of allogeneic blood and plasma in infants with combined immunodeficiency disease. (
  • Variation in blood component irradiation practice: implications for prevention of transfusion-associated graft-versus-host disease. (
  • Transfusion-associated graft-versus-host disease. (
  • Fatal graft-versus-host disease following blood transfusion in Hodgkin's disease documented by HLA typing. (
  • clinical and histologic changes of graft versus host disease occurring in a specific organ. (
  • Graft-versus-host (GVH) disease occurs when donor lymphocytes mount an immune response against the recipient's lymphoid tissue. (
  • What are the Types of Graft versus Host Disease? (
  • In graft versus host disease, the reverse occurs. (
  • What are the Symptoms and Signs of Graft versus Host Disease? (
  • Mouse colon impacted by acute graft-versus-host disease. (
  • In the classical sense, acute graft-versus-host-disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (
  • Newer research indicates that other graft-versus-host-disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis [1] . (
  • In the oral cavity , chronic graft-versus-host-disease manifests as lichen planus with a higher risk of malignant transformation to oral squamous cell carcinoma [10] in comparison to the classical oral lichen planus. (
  • Graft-versus-host-disease-associated oral cancer may have more aggressive behavior with poorer prognosis, when compared to oral cancer in non-hematopoietic stem cell transplantation patients. (
  • In the clinical setting, graft-versus-host-disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (
  • The chronic form of graft-versus-host-disease (cGvHD) normally occurs after 100 days. (
  • phase I trial is studying the side effects and best dose of donor mesenchymal stem cells in treating patients with acute or chronic graft-versus-host disease after undergoing a donor stem cell transplant. (
  • Within 72 hours after the initiation of medical therapy (e.g., corticosteroids, cyclosporine) for graft-vs-host disease, patients undergo donor MSC infusion over 10-15 minutes. (
  • To compare the effectiveness of Tacrolimus and Rapamycin to Tacrolimus and Methotrexate in the prevention of severe graft-versus-host-disease. (
  • Low dose Rabbit Antithymocyte Globulin plus Low-dose post-transplantation cyclophosphamide as graft-versus-host disease prophylaxis in haploidentical hematopoietic stem cell transplantatio. (
  • This pilot phase II trial studies how well carfilzomib works in treating patients with chronic graft-versus-host disease. (
  • Chronic graft-versus-host disease is a complication of a donor bon. (
  • Viable donor lymphocytes in RBC or platelet products can engraft in susceptible patients and cause fever, erythroderma, maculopapular rash, anorexia, nausea/vomiting, diarrhea, hepatitis, and pancytopenia (transfusion-associated graft-vs-host disease). (
  • Galipeau J (2013) The mesenchymal stromal cells dilemma-does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road? (
  • The risk benefit assessment for an individual patient depends on the patient characteristics, including disease, stage, risk factors, and specific manifestations of the disease, on characteristics of the graft, and on other available treatments or types of hematopoietic progenitor cells. (
  • Acute graft-versus-host disease (aGvHD) is the most frequent and serious complication following hematopoietic stem cell transplantation (HSCT), with a high mortality rate. (
  • Keywords: graft-versus-host disease, haemopoietic stem cell transplantation, donor lymphocyte infusion, immunosuppres- sive therapy, mesenchymal stem cells. (
  • There are two forms of graft vs. host disease: acute and chronic. (
  • The results of the comparison studies indicate that disease-free survival after transplantation of unrelated matched bone marrow or cord blood is similar and that the preliminatry results are very encouraging regarding improved leukemia-free survival after double-unit cord-blood grafts. (
  • The chronic form of graft-versus-host-disease (cGvHD) normally begins 90 to 600 days post-transplant. (
  • However, HSCT is frequently complicated by acute graft-versus-host disease (aGVHD) wherein donor T lymphocytes target recipient tissue antigens. (
  • Publications] Harada,Takayuki: 'Graft-Versus-Host Reaction and GvH disease' Tohoku Journal of Experimental Medicine. (
  • Publications] Harada, T.: 'Graft-versus-Host Reaction and GvH disease. (
  • TITLE: Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. (
  • The immunomodulatory effects of granulocyte colony-stimulating factor (G-CSF) on T cells result in a low incidence of acute graft-versus-host disease (aGVHD) in G-CSF-mobilized allogeneic peripheral blood stem cell transplantation (G-PBSCT). (
  • Chronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic stem cell transplantation with few effective options available after failure of corticosteroids. (
  • Chronic graft-versus-host disease (cGVHD) is a serious and life-threatening complication of allogeneic hematopoietic stem cell transplantation affecting 30% to 70% of patients. (
  • This type of transplant will not result in rejection or graft versus host disease 4 . (
  • She is diagnosed with early graft versus host disease. (
  • Use of unrelated marrow grafts compensates for reduced graft-versus-leukemia reactivity after T-cell-depleted allogeneic marrow transplantation for chronic myelogenous leukemia. (
  • The aim of this thesis was to examine some of the lymphoid effector cells which are involved in intestinal cell-mediated immune responses as exemplified by the intestinal phase of graft-verus-host reaction (GvHR). (
  • We have investigated the relevance of mucosal mast cells (MMC) to the mechanisms of this enteropathy by using graft-versus-host reaction (GvHR) in the rat as a model of mucosal delayed type hypersensitivity. (
  • The effects of potassium humate, at an oral dose of 60 mg/kg bodyweight, on a delayed type hypersensitivity reaction, a carrageenan-induced inflammation model and an allogeneic graft-versus-host reaction (GVHR) in rats were investigated. (
  • The effect of GVHR on thymus-dependent lymphocytes of various lymphoid organs has been followed autoradiographically and by scintillation technique in a temporal dependence on the induction of the reaction. (
  • Combination of ATL and ATH,which were congenic recombinant strains differing only in H-2I and S region from each other, was chosen to induce class II-GvHR.Selective activation against partner's alloantigen of graft CD4^+ T cells was the primary event of the GvHR and then led to concomitant activation of both graft and host cells. (
  • Graft-versus-host reaction(GVHR) following fresh whole blood transfusions. (
  • The recipient possesses transplantation antigens that are absent in the graft. (
  • Transplantation of 8 x 10(6) C57BL/6-Nu+/Nu+ (nude) bone marrow cells into C3H/HeJ recipients after conditioning with 8 Gy of total body irradiation has resulted in a markedly higher rate of graft rejection or graft failure compared to that found in recipients of normal C57BL/6 or C57BL/6-Bg+/Bg+ (beige) T-cell-depleted bone marrow. (
  • After bone marrow transplantation, T cells present in the graft , either as contaminants or intentionally introduced into the host, attack the tissues of the transplant recipient after perceiving host tissues as antigenically foreign. (
  • The quality of the renal transplant prior to transplantation is essential for the recovery of graft function in the days following transplantation and its long-term survival. (
  • The use of machine perfusion (MP) in kidney transplantation lowers delayed graft function (DGF) and improves 1-year graft survival in some, but not all, grafts. (
  • This study focused on the value of quantitatively analyzed and qualitatively graded renal scintigraphy in relation to the expected duration of delayed graft function after kidney transplantation. (
  • Predicition models for delayed graft function: external validation on The Dutch Prospective Renal Transplantation Registry. (
  • As a result of the current advancement in polymerase chain reaction techniques, TA-MC has been demonstrated among patients with trauma following blood transfusion , pregnancy and organ or stem cell transplantation . (
  • To determine whether graft-versus-leukemia (GVL) reactions are important in preventing leukemia recurrence after bone marrow transplantation, we studied 2,254 persons receiving HLA-identical sibling bone marrow transplants for acute myelogenous leukemia (AML) in first remission, acute lymphoblastic leukemia (ALL) in first remission, and chronic myelogenous leukemia (CML) in first chronic phase. (
  • Graft-versus-leukemia in bone marrow transplantation. (
  • Three-dimensional-porous scaffolds of bone graft substitutes play a critical role in both cell targeting and transplantation strategies. (
  • RePub, Erasmus University Repository: Graft-versus-leukemia : applicable in the treatment of leukemia with bone marrow transplantation? (
  • The graft-versus-tumor (GVT) effect after allogeneic bone marrow transplantation (BMT) can potentially cure many hematopoietic malignancies. (
  • The two main obstacles after islet transplantation are alloreactive T-cell-mediated graft rejection and recurrence of autoimmune diabetes mellitus in recipients. (
  • The mechanism of tumor eradication in allogeneic HSCT recipients is the immune-mediated graft-versus-tumor (GVT) effect. (
  • To investigate the effects of γδTregs on aGVHD, the association between γδTreg subsets in grafts and aGVHD in recipients was estimated. (
  • The possibility that modifying substances may differentially alter reactivity of parental lymphocytes and that considerations other than genotype determine the outcome of a GVH reaction are discussed in detail. (
  • A mobilization of T lymphocytes from the spleen and lymph nodes into the circulation already in the very first days of the reaction might be responsible for the peak seen in PBL and TDL. (
  • T-lymphocytes can cause a reaction when transfused. (
  • MLN cells to recirculate into host lymphoid tissues. (
  • If the substance being donated is similar to the tissues of the recipient, then the reaction can be lessened. (
  • Mononuclear phagocytes and other leukocytes are thought to be responsible for both initiation of graft-versus-host reaction and for the subsequent injury to host tissues after complex interactions with cytokines and chemokines ( 1 , 2 , 7 - 9 ). (
  • During the first phase, the conditioning regimen (irradiation and/or chemotherapy) leads to damage, activation of host tissues, including intestinal mucosa, and induces the secretion of inflammatory cytokines ( 8 - 11 ). (
  • We examined the effect of the source of IL-6 by analyzing the role IL-6 deficiency in donor T cells, donor bone marrow or in host tissues. (
  • The presence of a proinflammatory milieu is attributable to the (a) conditioning regimen, (b) the alloreaction, and (c) the damage induced in the host tissues as a consequence of both ( 5 , 6 ). (
  • TNF-α that activate allo-immune reactions culminating in aGVHD. (
  • The clinical data demonstrated that the proportion of CD27 + Vδ1Tregs in grafts was significantly lower in the patients who experienced aGVHD than in those who did not develop aGVHD ( P = 0.028), and the proportions of other γδTreg subsets in grafts did not differ significantly between the two groups. (
  • The best cutoff value for CD27 + Vδ1Treg proportion in grafts in prediction of aGVHD was 0.33%, with an area under the curve value of 0.725 ( P = 0.043). (
  • Hymes SR, Morison WL, Farmer ER, Walters LL, Tutschka PJ, Santos GW (1985) Methoxsalen and ultraviolet A radiation in treatment of chronic cutaneous graft-versus-host reaction. (
  • This is the opposite of transplant rejection wherein the graft tissue is rejected by the host immune cells. (
  • 16. Tile method of claim 13 wherein the graft is non-tumorogenic. (
  • Hemolytic transfusion reactions are the result of antibodies in the recipient's plasma directed against antigens on the donor's erythrocytes. (
  • The recipient's antibodies to Rh or non-ABO antigens cause extravascular hemolytic reactions. (
  • This is a medical emergency resulting from rapid destruction ( hemolysis ) of the donor red blood cells by host antibodies . (
  • If blood is transfused to a patient who already has antibodies to the transfused cells (giving this individual group B blood, for example) then a serious reaction can occur. (
  • The antibodies produced in such reactions tend not to activate complement, so the transfused red cells in circulation do not usually break down. (
  • Antibodies present in the blood recognise antigens on cells that are not native to an individual and trigger an agglutination reaction, which makes the blood clump, fatally. (
  • Actually it's much more likely to trigger a gross agglutination reaction in the recipient, because there will be very few incoming antibodies and white cells but lots of foreign antigen. (
  • Introduction into the rabbit's anterior chamber of lymphoid cells sensitized to the histocompatibility antigens of the recipient leads to the development of an intraocular graft versus host reaction. (
  • The immune system (body s defence mechanism) can recognize HLA antigens that are not belonging to the host (eg donor tissue) and can mount an immune attack against the graft. (
  • Occurs when donor T cells respond to host antigens. (
  • The presentation of host antigens by host APC can be further enhanced by host gamma/delta T cells, as recently shown in the mouse (Maeda et al, 2005). (
  • In particular combinations of strains differing whole MHC antigens, namely, DBA/2* (C57BL/6xDBA/2) F1 or BALB/c* (BALB/cxA/J) F1, preferential but not selective activation of graft CD4^+ cells was characteristically observed. (
  • A graft-versus-host reaction was induced in New Zealand Black X New Zealand White F1 hybrid mice by administration of New Zealand White spleen cells. (
  • Similar hybrid mice treated with high doses of cyclophosphamide (70mg/kg/week) were more immunosuppressed than mice with graft-versus-host reactions and had even greater survival times. (
  • Effect of host-versus-graft and graft-versus-host reactions on the immune response of mice to sheep red blood cells. (
  • In the more severe reactions, the foci of endothelial destruction may be so numerous as to overlap, resulting in complete immunologic destruction of the entire endothelium. (
  • Monitor patients and discontinue DUCORD infusion for severe reactions. (
  • An anaphylactic (or severe allergic ) reaction can occur at a rate of 1 per 30,000-50,000 transfusions . (
  • Delayed hemolytic transfusion reactions usually are not very severe, but sometimes do cause renal failure. (
  • These reactions can be more severe than in other patients because the loss of normal hemoglobin containing red cells and the inflammation caused by the reaction can trigger a sickle crisis. (
  • However, the reaction is less severe. (
  • A transfusion reaction occurs when incompatible blood is given to a recipient. (
  • In this lesson, we will take a look at what happens when a person experiences a transfusion reaction , which is a reaction of the body that occurs when transfused blood is attacked by the recipient's immune system, and a transplant rejection , which is a reaction of the body that occurs when a transplanted organ or tissue is attacked by the recipient's immune system. (
  • We mentioned that a transfusion reaction occurs when mismatched blood is transfused into a recipient and attacked by that person's immune system. (
  • Similar to an acute immune hemolytic reaction, this reaction occurs more slowly. (
  • These reactions are most common in people with selective IgA deficiency (although IgA deficiency is often asymptomatic , and people may not know they have it until an anaphylactic reaction occurs). (
  • Blood transfusions may be rejected by the recipient, resulting in a transfusion reaction, but such cases are relatively rare. (
  • Delayed hemolytic reactions occur in about one out of every 5,000 transfusions. (
  • Patients with sickle cell anemia are at greater risk of having delayed hemolytic reactions because they often receive many transfusions. (
  • After getting several transfusions, the person may be at higher risk for a reaction. (
  • Blood transfusions even between humans need to be conducted carefully to avoid these reactions. (
  • Some people have allergic reactions to blood transfusions. (
  • Most people who have a delayed hemolytic reaction have had blood transfusions or pregnancies in the past. (
  • People with delayed immune hemolytic reaction don't usually need any treatment, but will need special blood tests before they can have more blood transfusions. (
  • Marked enhancement of donor type chimerism was also found when F1 thymocytes were added to nude bone marrow cells, indicating that the enhancement of bone marrow engraftment by T cells is not only mediated by alloreactivity against residual host cells but may rather be generated by growth factors, the release of which may require specific interactions between T cells and stem cells or between T cells and bone marrow stroma cells. (
  • Separate effects of irradiation and of graft-versus-host reaction on rat mucosal mast cells. (
  • [ 2 , 3 ] This restricted indication is, however, likely to be broadened as a consequence of the improved patient and graft survival and cost-effectiveness data that have been seen in the last few years. (
  • These actions have translated to improvements in patient and graft survival over the last few years. (
  • Preferential survival of specific regulatory T cells was observed in the grafted animals. (
  • IL-2 add-back post allogeneic hematopoietic stem cell transplant (HSCT), combined with Sirolimus (SIR), Tacrolimus (TAC) will optimize Treg reconstitution and prevent graft versus host dis. (
  • Can transplant renal scintigraphy predict the duration of delayed graft function? (
  • The interplay of APC, T cells and cytokines is such that, in a mouse transplant model - with mismatch only between donor T cells and host APC, but not between donor and host gut-donor T cells still efficiently killed host gut cells, suggesting that tissue destruction can be achieved with a by-stander effect (Teshima et al, 2002b). (
  • Blood samples are obtained periodically and examined by immunoenzyme techniques for mixed lymphocyte reaction (as a surrogate marker for alloreactivity) and cytokine levels (TH1 [i.e., interleukin (IL)-2 and interferon-gamma], TH2 [i.e. (
  • The fact that donor cells require to an host lymphoid tissue in order to mediate alloreactive immune responses led me to compare the migration pathways of intravenously injected IEL with to those of other conventional lymphoid populations. (
  • Blood banks perform pretransfusion compatibility testing to avoid hemolytic reactions. (
  • Acute immune hemolytic reactions are very rare, but serious. (
  • Often, delayed hemolytic reactions don't have symptoms. (
  • Treatment with evasin-1 did not interfere with graft-versus-leukemia. (
  • The purpose of this trial is to evaluate the reduction in incidence and severity of delayed graft function with kidney allografts from donors >45 years after brain death (DBD). (
  • Initial patient evaluation should focus on vital signs and breath sounds, examination of skin for evidence of urticaria, and urinalysis for hemoglobinuria to determine the likelihood of a potentially serious transfusion reaction versus a mild allergic reaction or simple febrile reaction. (
  • A reaction determined to be a mild allergic reaction is the only scenario in which continuation of transfusion is permitted, provided symptoms have resolved following treatment and the blood administration set has NOT been disconnected from patient or from blood product. (
  • Any acute reaction other than a mild allergic reaction should follow emergency management approach below. (
  • An allergic reaction may present in a spectrum ranging from mild urticaria to anaphylaxis. (
  • The symptoms of an allergic reaction might be itching and hives. (
  • When patients have had allergic reactions to more than one transfusion in the past, they might be given an antihistamine or steroid before the transfusion to help prevent an allergic reaction. (
  • Acute immune hemolytic reaction. (
  • The symptoms of acute immune hemolytic reaction include fever, chills, dizziness, pain in the lower back or sides, dark urine, and breathing problems. (
  • Local graft versus host reactions within the anterior chamber of the eye: the formation of corneal endothelial pocks. (
  • Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. (
  • Bone graft substitute materials are used for a wide range of clinical applications. (
  • Our data, consistent with clinical observations, show elevation of serum levels of IL-6 in the hosts after allogeneic BMT. (
  • The recipient must not reject the graft. (
  • White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (
  • Its incidence and severity depends on several factors, such as prophylaxis method, donor/recipient matching, intensity of the condition- ing regimen and composition of the graft. (
  • Accordingly, emergency physicians must be familiar with and be able to manage adverse transfusion reactions, ranging from self-limited febrile responses to life-threatening intravascular hemolysis. (
  • Nonhemolytic febrile reactions are thought to stem from the formation of cytokines during the storage of the blood. (
  • Fever, rigors, respiratory distress, hypotension, and tachycardia can occur from reactions caused by hemolysis of incompatible red cells, bacterial contamination of the blood component, or transfusion-related acute lung injury. (
  • 1. A myocardial graft in an animal, comprising: a stable graft of skeletal myoblasts or cardiomyocytes incorporated in myocardial tissue of said animal. (
  • 5. The myocardial graft of claim 1 wherein said stable graft delivers recombinant molecules to the myocardial tissue. (
  • 7. A method for forming a stable myocardial graft in an animal, comprising: introducing skeletal myoblasts or cardiomyocytes in myocardial tissue of the animal so as to form a stable myocardial graft. (
  • 12. The method of claim 11 wherein the myocardial graft delivers recombinant molecules to the myocardial tissue. (
  • 13. A method for delivering recombinant molecules to myocardial tissue of an animal, comprising: establishing a stable graft of skeletal myoblasts or cardiomyocytes incorporated in myocardial tissue of the animal, wherein the myoblasts or cardiomyocytes deliver recombinant molecules to the myocardial tissue. (
  • This is the most common adverse reaction to a blood transfusion. (
  • The information you provide may prevent an adverse reaction in other patients receiving blood components from the same donor. (
  • Since the vaccine is derived from the patient's own blood, there is no adverse reaction reported. (
  • However, this alloreactivity not only has negative effects but also mediates graft versus tumor (GvT) effects and supposedly facilitates engraftment. (
  • The graft-versus-tumor (GVT) effect is a potent form of immunotherapy against many hematologic malignancies and some solid tumors. (
  • Anaphylactic reactions most often are observed in those patients with a hereditary immunoglobulin A (IgA) deficiency . (
  • 6. Patients should NOT routinely be premedicated with antihistamine unless they have a recurrent history of allergic reactions. (