The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The transference of a kidney from one human or animal to another.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The transference of a part of or an entire liver from one human or animal to another.
A dead body, usually a human body.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Elements of limited time intervals, contributing to particular results or situations.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
The transference of a pancreas from one human or animal to another.
Obstruction of flow in biological or prosthetic vascular grafts.
Partial or total replacement of the CORNEA from one human or animal to another.
The transference of a heart from one human or animal to another.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Partial or total replacement of all layers of a central portion of the cornea.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Continuance of life or existence especially under adverse conditions; includes methods and philosophy of survival.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. It may be induced passively by introducing graft-specific antibodies from previously immunized donors, which bind to the graft's surface antigens, masking them from recognition by T-cells; or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The return of a sign, symptom, or disease after a remission.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The degree to which BLOOD VESSELS are not blocked or obstructed.
The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Antibodies produced by a single clone of cells.
Transference of fetal tissue between individuals of the same species or between individuals of different species.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
Tissues, cells, or organs transplanted between genetically different individuals of the same species.
Polyester polymers formed from terephthalic acid or its esters and ethylene glycol. They can be formed into tapes, films or pulled into fibers that are pressed into meshes or woven into fabrics.
The vein which drains the foot and leg.
Therapy with two or more separate preparations given for a combined effect.
Prospective patient listings for appointments or treatments.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Transference of an organ between individuals of the same species or between individuals of different species.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Disease having a short and relatively severe course.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Transplantation between animals of different species.
A surgical procedure or KERATOPLASTY involving selective stripping and replacement of diseased host DESCEMET MEMBRANE and CORNEAL ENDOTHELIUM with a suitable and healthy donor posterior lamella. The advantage to this procedure is that the normal corneal surface of the recipient is retained, thereby avoiding corneal surface incisions and sutures.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The vessels carrying blood away from the capillary beds.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Single layer of large flattened cells covering the surface of the cornea.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Pathological processes of the KIDNEY or its component tissues.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or due to FUCHS' ENDOTHELIAL DYSTROPHY; ANGLE-CLOSURE GLAUCOMA; IRITIS; or aging.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Pathological processes of the LIVER.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
The period following a surgical operation.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Diseases of the cornea.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
The transference of either one or both of the lungs from one human or animal to another.
Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use.
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
The study of chance processes or the relative frequency characterizing a chance process.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Application of pharmaceutically active agents on the tissues of the EYE.
Formation and development of a thrombus or blood clot in the blood vessel.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Transplantation of an individual's own tissue from one site to another site.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The shell-like structure projects like a little wing (pinna) from the side of the head. Ear auricles collect sound from the environment.
Excision of kidney.
An encapsulated lymphatic organ through which venous blood filters.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Surgical shunt allowing direct passage of blood from an artery to a vein. (From Dorland, 28th ed)
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The plan and delineation of prostheses in general or a specific prosthesis.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The main artery of the thigh, a continuation of the external iliac artery.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Derivatives of propylene glycol (1,2-propanediol). They are used as humectants and solvents in pharmaceutical preparations.
Tumors or cancer of the LUNG.
A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)
The formation of LYMPHATIC VESSELS.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Tumors or cancer of the human BREAST.
A PREDNISOLONE derivative with similar anti-inflammatory action.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

Autografting with philadelphia chromosome-negative mobilized hematopoietic progenitor cells in chronic myelogenous leukemia. (1/5787)

Intensive chemotherapy given in early chronic phase of chronic myelogenous leukemia (CML) has resulted in high numbers of circulating Philadelphia (Ph) chromosome-negative hematopoietic progenitor cells (HPC). We have autografted 30 consecutive patients with CML in chronic phase with HPC collected in this way to facilitate restoration of Ph-negative hematopoiesis in bone marrow after high-dose therapy. Hematopoietic recovery to greater than 0.5 x10(9)/L neutrophils and to greater than 25 x 10(9)/L platelets occurred in all patients, a median of 13 (range, 9 to 32) days and 16 (range, 6 to 106) days postautograft, respectively. Regenerating marrow cells were Ph-negative in 16 (53%) patients and greater than 66% Ph-negative in 10 (33%) patients. Twenty-eight patients are alive 6 to 76 months (median, 24 months) after autografting. Three patients have developed blast crisis from which 2 have died. Eight patients are in complete cytogenetic remission at a median of 20 (range, 6 to 44) months with a median ratio BCR-ABL/ABL of 0.002 (range, <0.001 to 0.01). Eight patients are in major cytogenetic remission at a median of 22 (range, 6 to 48) months. No patient died as a consequence of the treatment. All patients had some degree of stomatitis that was severe in 15 (50%) patients. Gastrointestinal and hepatic toxicities were observed in about one fourth of patients. Thus, autografting with Ph-negative mobilized HPC can result in prolonged restoration of Ph-negative hematopoiesis for some patients with CML; moreover, most autograft recipients report normal or near normal activity levels, suggesting that this procedure need not to be associated either with prolonged convalescence or with chronic debility.  (+info)

Organ-selective homing defines engraftment kinetics of murine hematopoietic stem cells and is compromised by Ex vivo expansion. (2/5787)

Hematopoietic reconstitution of ablated recipients requires that intravenously (IV) transplanted stem and progenitor cells "home" to organs that support their proliferation and differentiation. To examine the possible relationship between homing properties and subsequent engraftment potential, murine bone marrow (BM) cells were labeled with fluorescent PKH26 dye and injected into lethally irradiated hosts. PKH26(+) cells homing to marrow or spleen were then isolated by fluorescence-activated cell sorting and assayed for in vitro colony-forming cells (CFCs). Progenitors accumulated rapidly in the spleen, but declined to only 6% of input numbers after 24 hours. Although egress from this organ was accompanied by a simultaneous accumulation of CFCs in the BM (plateauing at 6% to 8% of input after 3 hours), spleen cells remained enriched in donor CFCs compared with marrow during this time. To determine whether this differential homing of clonogenic cells to the marrow and spleen influenced their contribution to short-term or long-term hematopoiesis in vivo, PKH26(+) cells were sorted from each organ 3 hours after transplantation and injected into lethally irradiated Ly-5 congenic mice. Cells that had homed initially to the spleen regenerated circulating leukocytes (20% of normal counts) approximately 2 weeks faster than cells that had homed to the marrow, or PKH26-labeled cells that had not been selected by a prior homing step. Both primary (17 weeks) and secondary (10 weeks) recipients of "spleen-homed" cells also contained approximately 50% higher numbers of CFCs per femur than recipients of "BM-homed" cells. To examine whether progenitor homing was altered upon ex vivo expansion, highly enriched Sca-1(+)c-kit+Lin- cells were cultured for 9 days in serum-free medium containing interleukin (IL)-6, IL-11, granulocyte colony-stimulating factor, stem cell factor, flk-2/flt3 ligand, and thrombopoietin. Expanded cells were then stained with PKH26 and assayed as above. Strikingly, CFCs generated in vitro exhibited a 10-fold reduction in homing capacity compared with fresh progenitors. These studies demonstrate that clonogenic cells with differential homing properties contribute variably to early and late hematopoiesis in vivo. The dramatic decline in the homing capacity of progenitors generated in vitro underscores critical qualitative changes that may compromise their biologic function and potential clinical utility, despite their efficient numerical expansion.  (+info)

A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/mycophenolate mofetil in renal transplant recipients. (3/5787)

BACKGROUND: Between September 20, 1995 and September 20, 1997, 208 adult patients undergoing renal transplantation were randomized to receive tacrolimus/prednisone (n=106) or tacrolimus/prednisone/mycophenolate mofetil (n=102), with the goal of reducing the incidence of rejection. METHODS: The mean recipient age was 50.7+/-13.7 years. Sixty-three (30.3%) patients were 60 years of age or older at the time of transplantation. The mean donor age was 34.5+/-21.7 years. The mean cold ischemia time was 30.5+/-9.2 hr. The mean follow-up is 15+/-7 months. RESULTS: The overall 1-year actuarial patient survival was 94%; the overall 1-year actuarial graft survival was 87%. When the patient and graft survival data were stratified to recipients under the age of 60 who did not have delayed graft function, the overall 1-year actuarial patient survival was 97%, and the corresponding 1-year actuarial graft survival was 93%. There were no differences between the two groups. The overall incidence of rejection was 36%; in the double-therapy group, it was 44%, whereas in the triple therapy group, it was 27% (P=0.014). The mean serum creatinine was 1.6+/-0.8 mg/dl. A total of 36% of the successfully transplanted patients were taken off prednisone; 32% of the patients were taken off antihypertensive medications. The incidence of delayed graft function was 21%, the incidence of cytomegalovirus was 12.5%, and the initial and final incidences of posttransplant insulin-dependent diabetes mellitus were 7.0% and 2.9%; again, there was no difference between the two groups. CONCLUSIONS: This trial suggests that the combination of tacrolimus, steroids, and mycophenolate mofetil is associated with excellent patient and graft survival and a lower incidence of rejection than the combination of tacrolimus and steroids.  (+info)

Bone marrow transplantation in pediatric patients with therapy-related myelodysplasia and leukemia. (4/5787)

Eleven children underwent BMT for therapy-related MDS or leukemia, four from HLA-identical siblings and seven from unrelated donors. Ten of the 11 were conditioned with busulfan and cyclophosphamide as the majority had received prior irradiation to the chest and/or abdomen. All patients engrafted. Regimen-related toxicity was more common when compared to historical controls. Eight patients developed acute GVHD and four of eight who survived 100 days post transplant developed extensive chronic GVHD. Non-relapse related mortality occurred in three patients. Five patients developed recurrent malignancy: one died from recurrence of osteosarcoma, three died of recurrent leukemia or MDS and another developed two subsequent malignancies (duodenal carcinoma and anaplastic astrocytoma). Three survive disease-free at 14+, 22+ and 43+ months for a 2 year actuarial cancer-free survival of 24% (95% confidence interval = 5-53%). Although allogeneic BMT can be curative, regimen-related toxicity is frequent and recurrent malignancy remains the major obstacle.  (+info)

Infrainguinal revascularisation in the era of vein-graft surveillance--do clinical factors influence long-term outcome? (5/5787)

OBJECTIVES: To investigate the variables affecting the long-term outcome of infrainguinal vein bypass grafts that have undergone postoperative surveillance. DESIGN: A retrospective analysis. PATIENTS AND METHODS: Details of 299 consecutive infrainguinal vein grafts performed in 275 patients from a single university hospital were collected and analysed. All grafts underwent postoperative duplex surveillance. Factors affecting patency, limb salvage and survival rates were examined. These factors were gender, diabetes, hypertension, aspirin, warfarin, ischaemic heart disease, run-off, graft type, early thrombectomy, level of anastomoses and indication for surgery. RESULTS: The 6-year primary, primary assisted and secondary patency rates were 23, 47, and 57%, respectively. Six-year limb salvage and patient survival were 68 and 45%, respectively. Primary patency was adversely influenced by the use of composite vein grafts. Early thrombectomy was the only factor that significantly influenced secondary patency. Limb salvage was worse in diabetic limbs, limbs with poor run-off and in grafts that required early thrombectomy. Postoperative survival was better in males, claudicants and in patients who took aspirin. CONCLUSIONS: Although co-morbid factors did not influence graft patency rates, diabetes did adversely effect limb salvage. This study, like others before it, confirms that aspirin significantly reduces long-term mortality in patients undergoing infrainguinal revascularisation.  (+info)

A glial cell line-derived neurotrophic factor-secreting clone of the Schwann cell line SCTM41 enhances survival and fiber outgrowth from embryonic nigral neurons grafted to the striatum and to the lesioned substantia nigra. (6/5787)

We have developed a novel Schwann cell line, SCTM41, derived from postnatal sciatic nerve cultures and have stably transfected a clone with a rat glial cell line-derived neurotrophic factor (GDNF) construct. Coculture with this GDNF-secreting clone enhances in vitro survival and fiber growth of embryonic dopaminergic neurons. In the rat unilateral 6-OHDA lesion model of Parkinson's disease, we have therefore made cografts of these cells with embryonic day 14 ventral mesencephalic grafts and assayed for effects on dopaminergic cell survival and process outgrowth. We show that cografts of GDNF-secreting Schwann cell lines improve the survival of intrastriatal embryonic dopaminergic neuronal grafts and improve neurite outgrowth into the host neuropil but have no additional effect on amphetamine-induced rotation. We next looked to see whether bridge grafts of GDNF-secreting SCTM41 cells would promote the growth of axons to their striatal targets from dopaminergic neurons implanted orthotopically into the 6-OHDA-lesioned substantia nigra. We show that such bridge grafts increase the survival of implanted embryonic dopaminergic neurons and promote the growth of axons through the grafts to the striatum.  (+info)

Reduced kidney transplant rejection rate and pharmacoeconomic advantage of mycophenolate mofetil. (7/5787)

BACKGROUND: Several multinational controlled clinical trials have shown that triple therapy immunosuppressive regimens which include mycophenolate mofetil (MMF), cyclosporin A (CSA) and steroids (S) are superior compared with conventional regimens which include azathioprine (AZA), CSA and S, mainly because MMF reduces the rate of acute rejection episodes in the first 6 months after kidney transplantation. Post-marketing studies are useful to evaluate the general applicability and costs of MMF-based immunosuppressive regimens. METHODS: Based on the excellent results of the published controlled clinical trials, we have changed the standard triple therapy immunosuppressive protocol (AZA+CSA+S) to an MMF-based regimen (MMF+CSA+S) at our centre. To analyse the impact of this change in regimen, we have monitored 6-month patient and graft survival, rejection rate, serum creatinine and CSA levels, as well as the costs of the immunosuppressive and anti-rejection treatments, in 40 consecutive renal transplant recipients (MMF group) and have compared the data with 40 consecutive patients transplanted immediately prior to the change in regimen (AZA group). RESULTS: Recipient and donor characteristics were similar in the AZA and MMF groups. Patient survival (37/40; 92.5% in the AZA group vs 38/40; 95% in the MMF group), graft survival (36/40 vs 36/40; both 90%) and serum creatinine (137+/-56 vs 139+/-44 micromol/l) after 6 months were not significantly different. However, the rate of acute rejection episodes (defined as a rise in creatinine without other obvious cause and treated at least with pulse steroids) was significantly reduced with MMF from 60 to 20% (P=0.0005). The resulting cost for rejection treatment was lowered 8-fold (from sFr. 2113 to 259 averaged per patient) and the number of transplant biopsies was lowered > 3-fold in the MMF group. The cost for the immunosuppressive therapy was increased 1.5-fold with MMF (from sFr. 5906 to 9231 per patient for the first 6 months). CONCLUSIONS: The change from AZA to MMF resulted in a significant reduction in early rejection episodes, resulting in fewer diagnostic procedures and rehospitalizations. The optimal long-term regimen in terms of patient and pharmacoeconomic benefits remains to be defined.  (+info)

Right atrial bypass grafting for central venous obstruction associated with dialysis access: another treatment option. (8/5787)

PURPOSE: Central venous obstruction is a common problem in patients with chronic renal failure who undergo maintenance hemodialysis. We studied the use of right atrial bypass grafting in nine cases of central venous obstruction associated with upper extremity venous hypertension. To better understand the options for managing this condition, we discuss the roles of surgery and percutaneous transluminal angioplasty with stent placement. METHODS: All patients had previously undergone placement of bilateral temporary subclavian vein dialysis catheters. Severe arm swelling, graft thrombosis, or graft malfunction developed because of central venous stenosis or obstruction in the absence of alternative access sites. A large-diameter (10 to 16 mm) externally reinforced polytetrafluoroethylene (GoreTex) graft was used to bypass the obstructed vein and was anastomosed to the right atrial appendage. This technique was used to bypass six lesions in the subclavian vein, two lesions at the innominate vein/superior vena caval junction, and one lesion in the distal axillary vein. RESULTS: All patients except one had significant resolution of symptoms without operative mortality. Bypass grafts remained patent, allowing the arteriovenous grafts to provide functional access for 1.5 to 52 months (mean, 15.4 months) after surgery. CONCLUSION: Because no mortality directly resulted from the procedure and the morbidity rate was acceptable, this bypass grafting technique was adequate in maintaining the dialysis access needed by these patients. Because of the magnitude of the procedure, we recommend it only for the occasional patient in whom all other access sites are exhausted and in whom percutaneous dilation and/or stenting has failed.  (+info)

Here, we report that kidney-pancreas and kidney-islet transplants, when successful, prevent the worsening of graft survival and vascular function of the kidney graft that may occur in ESRD diabetic patients receiving kidney transplants. Noninvasive assessments of graft vascular function using RI and UAE evaluations showed that the KP and KI-s groups had better cumulative kidney graft survival at 2, 4, and 6 years than did the KD group. Expression of NOS in the kidney graft correlated well with the functional data, showing an early impairment of NO pathways in the glomerular vessels of KD-transplanted patients. Only the KP transplant group experienced a sustained compensatory hypertrophy of the kidney graft.. The transplanted kidney in ESRD type 1 diabetic patients is exposed to the deleterious effects of both diabetes and immunosuppression (34). Initially, diabetic nephropathy encompasses both functional changes (i.e., reduced renal vasodilatory reserve and reduced ability to respond to ...
Purpose: Several risk models have been developed to predict outcome after liver transplantation (LT) in the last decade. This study analyzes the ability of these risk models to predict patient, overall graft and death-censored graft survival at short- and long-term follow-up after transplantation.. *Methods: Data included information from the SRTR database on LTs from deceased donors performed in adults (>=18 years old) from January 1st, 2005 until December 31st, 2015. For all LTs the BAR-score, DRI, ET-DRI, DRM, sRRI, SOFT and D-MELD scores were calculated. Model performance was evaluated by the discriminative capacity and area under the ROC-curve (c-statistic) for patient survival, overall graft survival and death-censored graft survival. High-risk transplantations were defined as scores above 80th percentile according to the respective risk models.. *Results: In the study period, 62,294 LTs were included. Patient survival at 3 months was best predicted by the SOFT (c-statistic: 0.68) and BAR ...
In kidney transplantation, dynamic predictions of graft survival may be obtained from joint modelling of longitudinal and survival data for which a common assumption is that random-effects and error terms in the longitudinal sub-model are Gaussian. However, this assumption may be too restrictive, e.g. in the presence of outliers, and more flexible distributions would be required. In this study, we relax the Gaussian assumption by defining a robust joint modelling framework witht-distributed random-effects and error terms to obtain dynamic predictions of graft survival for kidney transplant patients. We take a Bayesian paradigm for inference and dynamic predictions and sample from the joint posterior densities. While previous research reported improved performances of robust joint models compared to the Gaussian version in terms of parameter estimation, dynamic prediction accuracy obtained from such approach has not been yet evaluated. Our results based on a training sample from the French DIVAT ...
Data & statistics on The actuarial graft and patient survival rate: The actuarial graft and patient survival rate., Actuarial Patient and Graft Survival Rates at Hopital Necker-Enfants Malades, Actuarial survival of patients grafted within 2 years of diagnosis or later: the difference is highly significant (P=0.0004). The diagnosis-transplantation (Dx-Tx) interval is not known for four patients....
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
TY - JOUR. T1 - A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival. AU - Michielsen, Laura A.. AU - Wisse, Bram W.. AU - Kamburova, Elena G.. AU - Verhaar, Marianne C.. AU - Joosten, Irma. AU - Allebes, Wil A.. AU - van der Meer, Arnold. AU - Hilbrands, Luuk B.. AU - Baas, Marije C.. AU - Spierings, Eric. AU - Hack, Cornelis E.. AU - van Reekum, Franka E.. AU - Bots, Michiel L.. AU - Drop, Adriaan C. A. D.. AU - Plaisier, Loes. AU - Seelen, Marc A. J.. AU - Sanders, Jan-Stephan F.. AU - Hepkema, Bouke G.. AU - Lambeck, Annechien J.. AU - Bungener, Laura B.. AU - Roozendaal, Caroline. AU - Tilanus, Marcel G. J.. AU - Voorter, Christien E.. AU - Wieten, Lotte. AU - van Duijnhoven, Elizabeth M.. AU - Gelens, Marielle. AU - Christiaans, Maarten H. L.. AU - van Ittersum, Frans J.. AU - Nurmohamed, Shaikh A.. AU - Lardy, Neubury M.. AU - Swelsen, Wendy. AU - van der Pant, Karlijn A.. AU - van der Weerd, Neelke C.. AU - ten Berge, Ineke J. M.. AU - Bemelman, ...
Immediately after renal transplantation, patients experience rapid and significant improvement of their clinical conditions and undergo considerable systemic and cellular modifications. However, some patients present a slow recovery of the renal function commonly defined as delayed graft function (DGF). Although clinically well characterized, the molecular mechanisms underlying this condition are not totally defined, thus, we are currently missing specific clinical markers to predict and to make early diagnosis of this event. We investigated, using a pathway analysis approach, the transcriptomic profile of peripheral blood mononuclear cells (PBMC) from renal transplant recipients with DGF and with early graft function (EGF), before (T0) and 24 hours (T24) after transplantation. Bioinformatics/statistical analysis showed that 15 pathways (8 up-regulated and 7 down-regulated) and 11 pathways (5 up-regulated and 6 down-regulated) were able to identify DGF patients at T0 and T24, respectively. Interestingly
Persistence of post-operative color Doppler abnormalities is linked to reduced graft survival in pediatric patients after liver ...
VELASQUEZ, Sonia Y.; GARCIA, Luis F. y ALVAREZ, Cristiam M.. Regulatory T cells and their influence in kidney allograft survival. Medicina (B. Aires) [online]. 2007, vol.67, n.5, pp.491-501. ISSN 0025-7680.. The immune response elicited by an allogenic transplant usually leads to an effector response resulting in allograft rejection; however, some individuals maintain a long-term functioning transplant without signs of rejection (operational tolerance) even in the absence of immunosuppression. It has been suggested that the same mechanisms are responsible for tolerance to self-antigens and alloantigens. One of such mechanisms is immune regulation and several cell subsets with regulatory properties have been identified. Among them, the best characterized cell populations are the regulatory T cells (Treg). Although Treg in mice are CD4+CD25+, in humans the Treg phenotype is restricted to CD4 T cells with high expression of CD25 (CD25high) and Foxp3. Phenotypic and functional analysis of ...
A recent study investigated whether the limited supply of kidneys for transplant could be alleviated by using more kidneys from deceased donors who had ...
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We can assume that the cellular content and proportions of different cell types in the HSCT graft are important in safe and efficient HSCT, as is also the spectrum of cytokines the cells secrete. However, there are no systematic studies on the immunological content of clinical HSCT grafts. In current HSCT protocols, the cell and cytokine profile of the graft is not characterized.. In the project we systematically characterise the immune cell profiles of clinical HSCT grafts and study their associations with the outcome of HSCT. From all grafts we estimate the numbers of the following cell populations ...
Is it possible that youre overpaying for biological surgical grafts? When you purchase grafts direct from Select Surgical Technologies, youll cut out the
Is it possible that youre overpaying for biological surgical grafts? When you purchase grafts direct from Select Surgical Technologies, youll cut out the
New polymeric adsorbents prepared by radiation-induced graft polymerization are superior to conventional adsorbents in terms of resolution in elution
TY - JOUR. T1 - Early renal function recovery and long-term graft survival in kidney transplantation. AU - Wan, Susan S.. AU - Cantarovich, Marcelo. AU - Mucsi, I.. AU - Baran, Dana. AU - Paraskevas, Steven. AU - Tchervenkov, Jean. PY - 2016/5/1. Y1 - 2016/5/1. N2 - Following kidney transplantation (KTx), renal function improves gradually until a baseline eGFR is achieved. Whether or not a recipient achieves the best-predicted eGFR after KTx may have important implications for immediate patient management, as well as for long-term graft survival. The aim of this cohort study was to calculate the renal function recovery (RFR) based on recipient and donor eGFR and to evaluate the association between RFR and long-term death-censored graft failure (DCGF). We studied 790 KTx recipients between January 1990 and August 2014. The last donor SCr prior to organ procurement was used to estimate donor GFR. Recipient eGFR was calculated using the average of the best three SCr values observed during the first ...
The ultimate goal of clinical transplantation is for the recipients to achieve long-term survival, with continuing graft function, that is equivalent to that of the age-matched general population. We studied subsequent outcome in kidney transplant recipients with 10 years of graft function. In all, 2202 kidney transplant recipients survived with graft function ,10 years. For 10-year survivors, the actuarial 25-year patient survival rate for primary transplant living donor (LD) recipients was 57%; graft survival, 43%. For primary transplant deceased donor (DD) recipients, the actuarial 25-year patient survival rate was 39%; graft survival, 27%. The two major causes of late graft loss were death (with graft function) and chronic allograft nephropathy (tubular atrophy and interstitial fibrosis). The two major causes of death with function were cardiovascular disease (CVD) and malignancy. For nondiabetic recipients, the mean age at death with function from CVD was 54 ± 13 years; for diabetic ...
TY - JOUR. T1 - Kidney allograft survival outcomes in combined intestinal-kidney transplant. T2 - An analysis of the UNOS/OPTN database 2000-2014. AU - Moinuddin, Irfan. AU - Yaqub, Muhammad Sohail. AU - Taber, Tim. AU - Mujtaba, Muhammad. AU - Sharfuddin, Asif. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background and objectives: Intestinal transplants carry a high morbidity/mortality. Kidney allograft outcomes after combined intestinal (IT) with kidney transplant (CIKT) remain largely uninvestigated. Materials and methods: The UNOS STAR database was queried to identify all such combined organ transplants from 2000 to 2015. Results: Out of a total 2215 (51.4% peds vs 48.6% adults) intestinal transplants, 111 (5.0%) CIKT were identified (32.4% peds vs 67.6% adults). Over the study period of CIKT, a total of 45.9% of these cases died with a functioning kidney graft. DGF rate was 9.0%. The 1-year reported kidney acute rejection rate was 6.3%. For the entire CIKT population over the entire study era, the ...
Association between Early Resistive Index Measurement and Early Graft Function and Long-Term Graft Survival after Kidney Transplantation: an Evidence-based Clinical Review
Multiple studies have documented racial differences in graft survival in kidney transplant recipients. Although several studies in adult kidney transplant recipients have evaluated risk factors that might predispose to these differences, studies in pediatric patients are lacking. This study retrospectively analyzed data from the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) to identify racial differences in kidney transplant outcomes and evaluate factors that might contribute to those differences. The study was restricted to the first NAPRTCS registry-reported kidney transplant for pediatric patients (age | or =21 yr) whose race was reported as either black or white. Univariate graft survival analyses were performed using the log rank statistic. Relative hazard rates for the effect of race on graft failure were determined using proportional hazards models. Multivariate analyses were restricted to patients with |30 d of graft survival and were adjusted for initial diagnosis,
Background. Chronic allograft nephropathy (CAN) is the leading cause of late allograft failure, with only limited treatment options. Blockade of the renin-angiotensin system (RAS) decreases progression in diabetic and non-diabetic renal disease, but the effect on CAN is as yet unclear. Therefore, we have studied retrospectively the effect of RAS blockade on renal survival in patients with biopsy-proven CAN.. Methods. The medical records of 72 patients with biopsy-proven CAN were evaluated with regard to time course of graft function, proteinuria, blood pressure, and antihypertensive and immunosuppressive treatment. Coxs proportional hazards model was used for analysing renal graft survival after the index biopsy.. Results. On univariate analysis, histological determinants influencing renal survival were the chronic interstitial and chronic tubular score, and clinical parameters were the serum creatinine level at the time of the biopsy, the relative change in serum creatinine level between 12 ...
BACKGROUND: The clinical and immunological relevance of a positive B-cell flow-cytometry (B-FCXM) crossmatch in renal transplantation is still controversial. METHODS: We retrospectively analysed 145 consecutive cadaveric renal transplantations performed from May 1991 to September 1995 in our institution. All grafts were transplanted following a negative IgG T-cell complement-dependent cytotoxicity crossmatch (T-CDCXM). Concomitantly to CDCXM, B-cell and T-cell FCXM were performed and results were expressed as a mean fluorescence index (FI). Two groups were compared: 116 recipients grafted with a negative B-FCXM vs a group of 19 patients grafted with a positive B-FCXM. RESULTS: The two groups were similar for length of cold ischaemia, donor and recipients age and degree of HLA mismatching. The proportion of patients with pre-transplant anti-HLA class I antibodies or a retransplantation was significantly increased in the positive B-FCXM group vs the negative B-FCXM group. Recipient survival at 48 ...
TY - JOUR. T1 - Allogeneic uterus transplantation in baboons. T2 - Surgical technique and challenges to long-term graft survival. AU - Tryphonopoulos, Panagiotis. AU - Tzakis, Andreas G.. AU - Tekin, Akin. AU - Johannesson, Liza. AU - Rivas, Krishna. AU - Morales, Pablo R.. AU - Wagner, Joseph. AU - Mölne, Johan. AU - Enskog, Anders. AU - Diaz-Garcia, Cesar. AU - Dahm-Kähler, Pernilla. AU - Berho, Mariana. AU - Zimberg, Stephen. AU - Falcone, Tommaso. AU - Ruiz, Philip. AU - Olausson, Michael. AU - Brännström, Mats. PY - 2014/1/1. Y1 - 2014/1/1. UR - http://www.scopus.com/inward/record.url?scp=84907397669&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84907397669&partnerID=8YFLogxK. U2 - 10.1097/TP.0000000000000322. DO - 10.1097/TP.0000000000000322. M3 - Letter. C2 - 25171537. AN - SCOPUS:84907397669. VL - 98. SP - e51-e56. JO - Transplantation. JF - Transplantation. SN - 0041-1337. IS - 5. ER - ...
Antigen-presenting cells (APCs) play an important role in transplant rejection and tolerance. In high-risk corneal transplantation, where the graft bed is inflamed and vascularized, immature APCs in the donor corneal stroma quickly mature and migrate to lymphoid tissues to sensitize host T cells. In this study, using a mouse model of corneal transplantation, we investigated whether enrichment of tolerogenic APCs (tolAPCs) in donor corneas can enhance graft survival in corneal allograft recipients with inflamed graft beds. Treatment of donor corneas with interleukin-10 (IL-10) and transforming growth factor-β1 (TGFβ1) altered the phenotype and function of tissue-residing APCs. Transplantation of these tolAPC-enriched corneas decreased frequencies of interferon gamma (IFNγ)+ effector T cells (Teffs), as well as allosensitization in the hosts, diminished graft infiltration of CD45+ and CD4+ cells, and significantly improved corneal allograft survival compared to saline-injected controls. These data
Background:Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival.Methods:|/s...
TY - JOUR. T1 - Late graft loss or death in pediatric liver transplantation. T2 - an analysis of the SPLIT database. AU - Soltys, K. A.. AU - Mazariegos, G. V.. AU - Squires, R. H.. AU - Sindhi, R. K.. AU - Anand, R.. AU - Dunn, Stephen. AU - Manendez, Jerome. AU - Flynn, Louise. AU - Jonas, Maureen. AU - Krawczuk, Laura. AU - Christoff, Marielle. AU - Kane, Robert. AU - Solomon, Harvey. AU - Phillips, Erin. AU - Ferrer, Laurie. AU - Heffron, Thomas. AU - DePaolo, Jill. AU - Pillen, Todd. AU - Davis, Laurel. AU - Bucuvalas, John. AU - Ryckman, Fred. AU - Hawkins, Andre. AU - Arya, Gajra. AU - Narkewicz, Michael R.. AU - Sokol, Ronald J.. AU - Karrer, Frederick. AU - Mark, Cara. AU - Orban-Eller, Kathy. AU - Humar, Abhi. AU - Durand, Brenda. AU - Studenski, Leslie. AU - Rand, Elizabeth. AU - Anderer, Kathleen. AU - Mazariegos, George. AU - Chien, Nydia. AU - Seward, Lynn. AU - Atkison, Paul. AU - Roden, Jay. AU - Mittal, Naveen. AU - Cutright, Lisa. AU - Telega, Grzegorz. AU - Lerret, ...
The impact of FSGS on graft survival in children is greatest in LD transplants, resulting in loss of expected LD graft survival advantage. The rationale for LD grafts in children with FSGS should be based on factors other than better outcomes typically associated with LD transplantation.
Introduction The ability to preserve organs prior to transplant is essential to the organ allocation process. Objective The purpose of this study is to describe the functional relationship between cold-ischemia time (CIT) and primary nonfunction (PNF), patient and graft survival in liver transplant. Methods To identify relevant articles Medline, EMBASE and the Cochrane database, including the non-English literature identified in these databases, was searched from 1966 to April 2008. Two independent reviewers screened and extracted the data. CIT was analyzed both as a continuous variable and stratified by clinically relevant intervals. Nondichotomous variables were weighted by sample size. Percent variables were weighted by the inverse of the binomial variance. Results Twenty-six studies met criteria. Functionally, PNF% = −6.678281+0.9134701*CIT Mean+0.1250879*(CIT Mean−9.89535)2−0.0067663*(CIT Mean−9.89535)3, r2 = .625, , p|.0001. Mean patient survival: 93 % (1 month), 88 % (3 months), 83 %
Abstract:. Background. Liver transplantation is the standard of care for the treatment of liver failure worldwide, yet millions of people living in sub-Saharan Africa remain without access to these services. South Africa (SA) has two liver transplant centres, one in Cape Town and the other in Johannesburg, where Wits Donald Gordon Medical Centre (WDGMC) started an adult liver transplant programme in 2004.. Objectives. To describe the outcomes of the adult liver transplant programme at WDGMC.. Methods. This was a retrospective review of all adult orthotopic liver transplants performed at WDGMC from 16 August 2004 to 30 June 2016 with a minimum follow-up of 6 months. The primary outcome was recipient and graft survival and the effect of covariates on survival. Kaplan-Meier survival analysis included all adults who underwent their first transplant for end-stage liver disease (ESLD) (N=275). Proportional hazards regression analysis using hazard ratios (HRs) was conducted to determine which ...
Background. The molecular mechanism of small-forsize graft injury remains unclear. The aim of this study is to investigate the gene expression pattern of acute phase response in relation to graft size in a rat-liver transplantation model. Methods. A rat orthotopic liver transplantation model using 30%, 50%, and whole grafts was used. The graft survival rates and liver morphology were compared among the three groups. Two transcription factors, nuclear factor (NF)-κB (p65) and early growth response (Egr-1), and their downstream genes were compared. Results. According to the graft size, the rats were grouped as follows: group 1 (n=20), 32% (24-47%); group 2 (n=10), 56% (50-65%); and group 3 (n=10), 104% (89-120%). The 7-day survival rates were 20% (P=0.039 vs. group 2, P=0.000 vs. group 3), 60%, and 100% in groups 1, 2, and 3, respectively. Dilation of hepatic sinusoids and vacuolization of hepatocytes were observed in group 1. Up-regulation of Egr-1 and endothelin (ET)-1 and over-expression of ...
A new kidney allocation system, expected to be implemented in late 2014, will characterize donors on a percent scale (0%-100%) using the kidney donor profile index (KDPI). The 20% of deceased donor kidneys with the greatest expected posttransplant longevity will be allocated first to the 20% of candidates with the best expected posttransplant survival; kidneys that are not accepted will then be offered to remaining 80% of candidates. Waiting time will start at the time of maintenance dialysis initiation (even if before listing) or at the time of listing with an estimated glomerular filtration rate of 20 mL/min/1.73 m(2) or less. Under the current system, the number of candidates on the waiting list continues to increase, as each year more candidates are added than are removed. Median waiting times for adults increased from 3 years in 2003 to more than 4.5 years in 2009. Donation rates have not increased. Short-term outcomes continue to improve; death-censored graft survival at 90 days ...
Skin allograft survival.Compared to the control group, only the combination cell therapy significantly prolonged graft survival (p = 0.028).
Modern immunosuppression regimens effectively control acute rejection and decrease graft loss in the first year after transplantation; however, these regimens do not have a durable effect on long-term graft survival owing to a combination of drug toxicities and the emergence of chronic alloimmune responses. Eliminating drugs and their toxicities while maintaining graft acceptance has been the primary aim of cellular therapies. Tregs suppress both autoimmune and alloimmune responses and are particularly effective in protecting allografts in experimental transplant models. Further, Treg-based therapies are selective, do not require harsh conditioning, and do not have a risk of graft-versus-host disease. Trial designs should consider the distinct immunological features of each transplanted organ, Treg preparations, dose, and frequency, and the ability to detect and quantify Treg effects in a given transplant environment. In this Review, we detail the ongoing clinical trials of Treg therapy in liver ...
Modern immunosuppression regimens effectively control acute rejection and decrease graft loss in the first year after transplantation; however, these regimens do not have a durable effect on long-term graft survival owing to a combination of drug toxicities and the emergence of chronic alloimmune responses. Eliminating drugs and their toxicities while maintaining graft acceptance has been the primary aim of cellular therapies. Tregs suppress both autoimmune and alloimmune responses and are particularly effective in protecting allografts in experimental transplant models. Further, Treg-based therapies are selective, do not require harsh conditioning, and do not have a risk of graft-versus-host disease. Trial designs should consider the distinct immunological features of each transplanted organ, Treg preparations, dose, and frequency, and the ability to detect and quantify Treg effects in a given transplant environment. In this Review, we detail the ongoing clinical trials of Treg therapy in liver ...
Modern immunosuppression regimens effectively control acute rejection and decrease graft loss in the first year after transplantation; however, these regimens do not have a durable effect on long-term graft survival owing to a combination of drug toxicities and the emergence of chronic alloimmune responses. Eliminating drugs and their toxicities while maintaining graft acceptance has been the primary aim of cellular therapies. Tregs suppress both autoimmune and alloimmune responses and are particularly effective in protecting allografts in experimental transplant models. Further, Treg-based therapies are selective, do not require harsh conditioning, and do not have a risk of graft-versus-host disease. Trial designs should consider the distinct immunological features of each transplanted organ, Treg preparations, dose, and frequency, and the ability to detect and quantify Treg effects in a given transplant environment. In this Review, we detail the ongoing clinical trials of Treg therapy in liver ...
Modern immunosuppression regimens effectively control acute rejection and decrease graft loss in the first year after transplantation; however, these regimens do not have a durable effect on long-term graft survival owing to a combination of drug toxicities and the emergence of chronic alloimmune responses. Eliminating drugs and their toxicities while maintaining graft acceptance has been the primary aim of cellular therapies. Tregs suppress both autoimmune and alloimmune responses and are particularly effective in protecting allografts in experimental transplant models. Further, Treg-based therapies are selective, do not require harsh conditioning, and do not have a risk of graft-versus-host disease. Trial designs should consider the distinct immunological features of each transplanted organ, Treg preparations, dose, and frequency, and the ability to detect and quantify Treg effects in a given transplant environment. In this Review, we detail the ongoing clinical trials of Treg therapy in liver ...
Modern immunosuppression regimens effectively control acute rejection and decrease graft loss in the first year after transplantation; however, these regimens do not have a durable effect on long-term graft survival owing to a combination of drug toxicities and the emergence of chronic alloimmune responses. Eliminating drugs and their toxicities while maintaining graft acceptance has been the primary aim of cellular therapies. Tregs suppress both autoimmune and alloimmune responses and are particularly effective in protecting allografts in experimental transplant models. Further, Treg-based therapies are selective, do not require harsh conditioning, and do not have a risk of graft-versus-host disease. Trial designs should consider the distinct immunological features of each transplanted organ, Treg preparations, dose, and frequency, and the ability to detect and quantify Treg effects in a given transplant environment. In this Review, we detail the ongoing clinical trials of Treg therapy in liver ...
Modern immunosuppression regimens effectively control acute rejection and decrease graft loss in the first year after transplantation; however, these regimens do not have a durable effect on long-term graft survival owing to a combination of drug toxicities and the emergence of chronic alloimmune responses. Eliminating drugs and their toxicities while maintaining graft acceptance has been the primary aim of cellular therapies. Tregs suppress both autoimmune and alloimmune responses and are particularly effective in protecting allografts in experimental transplant models. Further, Treg-based therapies are selective, do not require harsh conditioning, and do not have a risk of graft-versus-host disease. Trial designs should consider the distinct immunological features of each transplanted organ, Treg preparations, dose, and frequency, and the ability to detect and quantify Treg effects in a given transplant environment. In this Review, we detail the ongoing clinical trials of Treg therapy in liver ...
TY - JOUR. T1 - Adult liver transplantation in the USA. AU - Alqahtani, Saleh Ali. AU - Larson, Anne M.. PY - 2011. Y1 - 2011. N2 - Purpose of review: To provide the nontransplant clinician with a basic understanding of the liver transplant process. Recent findings: Since its inception, the technique of liver transplantation and patient management has evolved considerably. We present an up-to-date overview of the evaluation of the transplant recipient and the listing and timing of transplant. We conclude with a brief summary of long-term complications, which should be considered when caring for the posttransplant patient. Summary: Liver transplantation is the only definitive treatment option for patients dying of liver failure. The growing population of patients with liver disease means that more transplants will be performed. As these patients now live longer lives, it is crucial that clinicians have a basic understanding of the process and outcomes.. AB - Purpose of review: To provide the ...
Results: In untreated control groups (n=5) animals rejected skin grafts, solid organ grafts and hind limb transplants acutely by POD 14 (± 1 day), POD 9 (± 2 days), and 8 (± 1 day), respectively. The induction regimen extended skin graft survival to 32 ± 8 days (n=5). Additional donor BM augmentation lead to allograft survival of 150 days in 4 of 5 recipients. However, indefinite graft survival of ,150 days was observed in all animals receiving the induction regimen and a VCA. Mixed chimerism analysis showed engraftment of donor BM in groups receiving BM at the time of skin transplantation (6.8% ± 3.1%). In groups receiving a VCA alone or an allograft augmented with donor BM and splenocytes, donor chimerism was detected at 22.51% ± 5.96% and 30.17% ± 8.72%, respectively. Vβ-T cell receptor staining showed decreased expression of Vβ 5.1/5.1 and Vβ 8.1/8.2 in animals receiving the full induction regimen compared to controls indicating a central selection and depletion mechanism for ...
This cohort study evaluates the association of deceased donor acute kidney injury with recipient graft survival and characterizes recovery and discard practices
This research grant spans a multidisciplinary innovation experiment involving reproductive preservation, biomolecular imaging and regenerative medicine. The purpose is to explore the most frequent multiple factors to affect the survival rate of immature testicular grafts which deserves to improve the survival rate of the immature graft from lacking spermatogenesis to spermatogenesis over time in the long run. Our long term series of applied bioluminescence imaging in vivo to track the grafts under 3-D in vivo imaging system (IVIS) system to analyze the graft survival in a longitudinal real-time model that may create much faster and more convicing data on a quality and quantity basis even in the experiment to adjust the drugs delivery or able to reduce multiple error trials. In the experiment, the same animals were used for continuous observation to reduce untoward sacrified mouse model that may meet the 3R principles of substitution, reduction and sophistication. While the fate mapping of ...
Aim: To evaluate if baseline serum lipids are associated with islet graft survival in type 1 diabetes mellitus islet transplant (ITx) recipients.. Research design and methods: Baseline fasting lipid profile was collected from 44 ITx recipients. Comparisons were performed between subjects below and above the median values of each lipid fraction. Differences in outcomes were compared by Kaplan-Meier curves and Cox-regression analysis.. Results: Subjects with baseline fasting plasma triglycerides and VLDL-cholesterol above median had shorter islet graft survival (triglycerides: 39.7±6.1 vs. 61.3±6.6 months, P=0.029 and VLDL: 41.5±5.7 vs. 62.8±7.3 months, P=0.032). Total, LDL and HDL-cholesterol didnt influence islet function. Triglycerides (OR=2.97, 95%CI=1.03-8.52, P=0.044) maintained its association with graft failure after adjustments for confounders.. Conclusions: Higher baseline triglycerides are associated with earlier decline in islet graft function. Prospective clinical trials should ...
Shapiro, R and Tzakis, AG and Hakala, TR and Lopatin, WB and Stieber, AC and Starzl, TE (1989) Renal transplantation in black recipients at the University of Pittsburgh. Transplantation Proceedings, 21 (6). 3921 - 3925. ISSN 0041-1345 ...
Fingerprint Dive into the research topics of Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720. Together they form a unique fingerprint. ...
When Cetrulos team used skin from these Gal-free pigs to provide grafts covering burn-like injuries on the backs of baboons - injuries made while the animals were under anesthesia - the grafts adhered and developed a vascular system within 4 days of implantation. Signs of rejection began to appear on day 10, and rejection was complete by day 12 - a time frame similar to what is seen with deceased-donor grafts and identical to that observed when the team used skin grafts from other baboons. As with the use of second deceased-donor grafts to treat burned patients, a second pig-to-baboon graft was rapidly rejected. But if a pit-to baboon was followed by a graft using baboon skin, the second graft adhered to the wound and remained in place for around 12 days before rejection. The researchers also showed that acceptance of a second graft was similar no matter whether a pig xenograft or a baboon skin graft was used first ...
TY - JOUR. T1 - Whats the score?. AU - Nyberg, Scott L.. PY - 2004/8/1. Y1 - 2004/8/1. N2 - In summary, a quantitative approach to assessing quality of donor organs, such as a donor scoring system, is not perfect as pointed out by Sing et al. However, in all of our studies involving deceased donors we have found that consideration of multiple donor variables is more predictive of long-term graft survival than any single donor variable. The donor score is a practical tool as it provides a continuum of points to estimate likelihood of success following transplantation. In the case of a deceased donor kidney with improved donor score less than 20 points, there is over 75% likelihood of good or excellent renal function at one year post-transplant. In contrast, if the donor score is 20-29 points, the likelihood of good-to-excellent function falls to 45%, and with a donor score of 30 or greater the likelihood of good-to-excellent function falls to 27%. We do not feel that a scoring system should be ...
One month following graft injection, no significant difference was noted between M2-supplemented (105±7.0 mm3) and control graft volumes (72±22 mm3). By three months post-injection, M2-supplemented grafts remained stable while controls experienced further volume loss (103±8 mm3 vs. 39.4±15 mm3, p=0.015). Presence of M2 macrophages in the supplemented grafts was confirmed by flow cytometry. M2-supplemented grafts demonstrated a 157% increase in vascular density compared to controls (p,0.05). Induction of adipogenic C/EBPα gene expression was observed when M2 supernatants were added to SVF containing ASC ...
Joseph Phan, Mercer University College of Pharmacy The Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline for the care of kidney transplant recipients states that prolonged maintenance of immunosuppressive therapy after kidney transplantation has improved short-term outcomes in many cases, however this effect on long-term allograft survival is not known. The current standard-of-care combines…
Liver grafting is now established as the optimal treatment for patients with end-stage parenchymal liver disease. Twenty-three years of experience at a single center is presented. The 1-year actuarial patient survival rate for all cases transplanted in Cambridge has now risen from 10% in 1968 to 1970 to 80% in 1990 to 1991. Increasing numbers of patients are being referred for transplantation with an ever-increasing range of indications being developed. Many inborn errors of metabolism can now be cured by liver grafting. There is still, however, considerable scope for improvement in many areas of patient treatment from operative and postoperative care to long-term immunosuppressive management. Much remains to be done to minimize early sepsis- and rejection-related deaths and late immunosuppression-related morbidity.
Purpose: Our goal for this study was to determine the relative fates of endogenous Foxp3- conventional (Tconv) and Foxp3+ regulatory T cells (Tregs) specific for alloantigens as compared to non-antigen-specific T cells in the context of murine allotransplantation.. Methods: To selectively study alloreactive endogenous Tregs, donor hearts from F1 (BALB/cxC57BL/6) mice expressing the model antigen 2W were transplanted into C57BL/6 recipients, and 2W:I-Ab tetramers were used to track peripheral 2W:I-Ab-specific Tregs and Tconv cells. Long-term graft survival was induced in two groups of mice with co-stimulation blockade (CoB) comprising either anti-CD154 (D0, 7 and 14) + donor splenocytes (D0), or CTLA-4Ig (D0 and 2). Mice were sacrificed at D7 and D30, and their splenic T cells were phenotyped.. Results:Whereas the percentages or total numbers of 2W-reactive Tregs in secondary lymphoid organs were similar at d7 in naïve, acutely rejecting, and CoB-treated mice, at 30d post-transplant, recipients ...
Transplant Immunosuppression 2019: Hot Topics will focus on current options for immunosuppression (and whats in the pipeline), with particular attention to individualization of immunosuppression based on clinical and/or laboratory parameters; prevention, diagnosis and treatment of antibody-mediated rejection; improving long-term transplant outcomes; and major issues in transplant-related infectious disease, living donation, and patient-centered care.
MP preservation of DCD kidneys is superior to CS in terms of reducing DGF rate post-transplant. However, primary non-function, one year graft survival, and one year patient survival were not affected by the use of MP or CS for preservation.
How is Long-Lasting Delayed Graft Function abbreviated? LLDGF stands for Long-Lasting Delayed Graft Function. LLDGF is defined as Long-Lasting Delayed Graft Function very rarely.
To investigate the causes of gastrointestinal bleeding (GIB) and its impact on patient and graft survival after orthotopic liver transplantation (OLTx), the first 1000 consecutive OLTx using tacrolimus were studied. Our patient population consisted of 834 adults. The bleeding episodes of patients with GIB (n=74) were analyzed, and patients without GIB (n=760) were used as controls. The mean age, gender, and United Network for Organ Sharing status were similar in both groups. Endoscopy was done in 73 patients with GIB and yielded a diagnosis in 60 patients (82.2%): 39 with a single, and 21 with multiple GIB episodes. In the remaining 13 patients (17.8%), the bleeding source was not identified. Of 92 GIB episodes with endoscopic diagnoses, ulcers (n=25) were the most common cause of bleeding, followed by enteritis (n=24), portal hypertensive lesions (n=15), Roux-en-Y bleeds, and other miscellaneous events (n=28). The majority (73%) of the GIB episodes occurred during the first postoperative ...
Novel research reveals racial and socioeconomic disparities among pediatric liver transplant patients. Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and ...
Here, we will know about FAQs common questions on the Kidney transplant 1. Which is the best treatment option for chronic kidney disease patient? Renal transplant is the best treatment option for the majority of chronic kidney patients. 2. What are the two kinds of transplant? Kidney for transplant may come from a person who … Read more ...
Kidney transplant at Emory Transplant Center is a nationally recognized program, performing more than 5,000 kidney transplants to date
How is Combined Pancreas-/Kidney Transplantation abbreviated? CPKT stands for Combined Pancreas-/Kidney Transplantation. CPKT is defined as Combined Pancreas-/Kidney Transplantation somewhat frequently.
Over time, off-pump bypass surgery grafts may fail. This eMedTV resource discusses graft failure and off-pump bypass surgery, including how long grafts typically last and tips that can help delay graft failure after surgery.
This study demonstrates for the first time, to our knowledge, the induction of stable insulin-free long-term operational tolerance in diabetic nonhuman primates given a single-donor allogeneic islet transplant with multiple MHC incompatibilities. Notably, all IPIT recipients given F(Ab)2-IT plus DSG experienced prolonged graft survival without maintenance immunosuppressive therapy or exogenous insulin and several (four of seven) are currently ,1-year survivors in excellent health with documented normoglycemia and immune competence.. Sharp et al. (26) first demonstrated the potential of the STZ-induction model for diabetes studies in primates. The studies of Theriault et al. (17) and Jonasson et al. (18) meticulously characterized glycemic parameters in STZ-induced cynomolgus and rhesus macaques, respectively. Jonasson et al. (18) also detailed secondary complications in an 11-year follow up of rhesus STZ-induced type 1 diabetes. With the caveat that evidence for autoimmune involvement is ...
Judith A. Kapp, PhD Dr. Kapps research focuses on identifying mechanisms of inducing and abrogating immunological tolerance. Our long-term goal is to translate our findings into novel therapies for preventing graft rejection and augmenting tumor immunity.. A long-term goal is to use knowledge gained from tumor studies and the induction of tolerance to develop methods to prolong graft survival. We have studied two transplantation models. This first involves transplantation of retinal pigment epithelial (RPE) cells as a treatment for age-related macular degeneration (AMD), which is the leading cause of blindness in people over the age of 65 in this country. This disease ultimately results from the loss of light sensing (photoreceptor) cells. However, the loss of photoreceptor cells is preceded by loss of the underlying RPE. Replacement of dead or damaged cells with healthy retinal cells is a very promising approach to the treatment of this, and other, retinal diseases that we are investigating. ...
FTY720 was originally developed for preventing allograft rejection (Adachi et al., 1995; Chiba et al., 1999; Suzuki, 1999). It prolongs graft survival in recipient rats with liver allografts and in canine kidney recipients, partly because of lymphocyte apoptosis, especially in CD4-positive cells (Enosawa et al., 1996). Furthermore, FTY720 is known to induce apoptosis in several cell lines and primary lymphocytes in vivo and in vitro (Shinomiya et al., 1997; Matsuda et al., 1998,1999; Wang et al., 1999; Nagahara et al., 2000; Sonoda et al., 2001). Apoptosis, a programmed cell death, or the cellular suicide program, is a fundamental biological process that plays requisite roles in the development, differentiation, and maintenance of cells. Inappropriate or dysregulated apoptosis, or failure to undergo programmed cell death, has been implicated in a number of diseases and pathological conditions (Thompson, 1995).. Understanding of biochemical events in apoptosis was significantly advanced by the ...
The mediation of transplant rejection by allogeneic immune responses remains the main impediment to prolonged graft survival and to the achievement of tolerance. Adequate cell activation and differentiation is required for efficient immune responses to develop, and the balance between regulatory and effector cells serves as a key determinant of transplantation outcome. Understanding of the different signalling pathways and transcriptional patterns which characterize particular immune cell subsets led to the identification of novel targets for the improved monitoring and treatment of transplanted patients. More recently, it has emerged that the reprogramming of complex intracellular metabolic pathways also plays a crucial part in shaping immune cell function.1 As a consequence, attention has turned toward the interrogation and manipulation of the metabolic status of immune cells with a view to developing novel monitoring tools and therapeutic approaches.. Because of their lower metabolic ...
Leitão, Cristiane (March 2010). "Lipotoxicity and Decreased Islet Graft Survival". Diabetes Care. 33 (3): 658-660. doi:10.2337/ ...
Thompson, RW Jr; Price, MO; Bowers, PJ; Price, FW Jr (2003-06-01). "Long-term graft survival after penetrating keratoplasty". ... PDEK graft is thicker than isolated DM graft and hence there is less intraoperative graft handling challenges like torn graft, ... Postoperative graft detachment can happen in eyes with insufficient air or loss of air after surgery.1,6 If the graft is ... The injector along with the graft is inserted via the corneal wound and the graft is injected in the anterior chamber (Fig 3C ...
Although short-term immunosuppression concerning patient and graft survival is found to be similar between the two drugs, ... McCauley, Jerry (19 May 2004). "Long-Term Graft Survival In Kidney Transplant Recipients". Slide Set Series on Analyses of ... and this may have important long-term implications given the prognostic influence of rejection on graft survival. Oral ... In people receiving immunosuppressants to reduce transplant graft rejection, an increased risk of malignancy (cancer) is a ...
"Kenya Graft Probe of Treasury Head Highlights Power Struggle". www.bloomberg.com. Herbling, David. "Schism in Kenya Ruling ... "Infighting threatens Jubilee Party's survival - Daily Nation". www.nation.co.ke. Retrieved 1 April 2019. Ombok, Eric; Herbling ...
Al-Mezaine H, Wagoner MD (March 2006). "Repeat penetrating keratoplasty: indications, graft survival, and visual outcome". The ... The corneal epithelium is removed and a lenticule of donor cornea is grafted on top of it. The procedure requires a greater ... Research from two trials in Iran provide low to moderate evidence that graft rejection is more likely to occur in penetrating ... The corneal transplant surgeon trephines a lenticule of corneal tissue and then grafts the donor cornea to the existing eye ...
Alcohol and smoking can contribute to poor graft survival. Post operative antibiotics are commonly prescribed to prevent wound ... Hair transplantation differs from skin grafting in that grafts contain almost all of the epidermis and dermis surrounding the ... Modern transplant techniques began in Japan in the 1930s, where surgeons used small grafts, and even "follicular unit grafts" ... The surgeon then uses very small micro blades or fine needles to puncture the sites for receiving the grafts, placing them in a ...
Leto described This Is War as a record about survival: "It was a two-year creative battle that was ferocious and tough but ... Gary, Graff (December 17, 2009). "30 Seconds To Mars Plans To 'Extend The Interactivity' On Tour". Billboard. Retrieved August ... Harris, Chris (December 8, 2009). "30 Seconds To Mars Sing About Survival on "This Is War"". Rolling Stone. Retrieved August 29 ...
Ptak W, Festenstein H, Asherson GL, Denman AM (1969). "Improved graft survival after treatment with Bordetella and anti- ...
Post-transplant hypertension at one year: Impact on long-term graft survival. Raju DSB, Agarwal SK, Gupta S, Dash SC, Bhowmick ...
Patients who received successful bone marrow transplants had a 2-year survival rate of 68% and a 10-year survival rate of 64%. ... Patients can develop graft versus host disease; this is more likely in non-sibling donors. In a 1998 study, children with HLA- ... identical sibling donors had a 5-year survival of 75%; children with non-sibling donors had a 5-year survival of 53%. Children ... In these cases, UCBT from unrelated donors can increase survival, decrease physical signs of the disease, and improve cognition ...
"Causes of limited survival of microencapsulated pancreatic islet grafts". J. Surg. Res. 121 (1): 141-50. doi:10.1016/j.jss. ... grafted a solid, but permeable, shell around the cells to provide increased mechanical strength. Sodium Citrate is used for ... The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering ... Approximately a doubling of survival time compared to historic controls was demonstrated. Questions could arise as to why the ...
Genetic variants of FOXP3 influence graft survival in kidney transplant patients. „Hum Immunol". 74 (6), s. 751-757, czerwiec ... High regulatory T-cell levels at 1 year posttransplantation predict long-term graft survival among kidney transplant recipients ... Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival. „J ... CD4+CD25+ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model. „Cell Immunol". 285 (1-2). s ...
An Isograft is a graft of tissue between two individuals who are genetically identical (i.e. monozygotic twins). Transplant ... Effect of STZ Administration on Islet Isograft and Allograft Survival in NOD Mice. Diabetes Vol 42, February 1993. Retrieved 25 ... Furthermore, there is virtually no incidence of graft-versus-host disease. In 1993 a research article demonstrated that islet ...
King, K. B., & Reis, H. T. (2012). Marriage and long-term survival after coronary artery bypass grafting. Health Psychology, 31 ...
However, there have been cases of survival. As of 2004, there were only two reported living cases. Of these two, one was ... Proceeding with a bone graft when the child reaches school age is also recommended. Usually babies with this malformation do ...
... long-term graft survival is similar to recipients who receive ABOc kidneys. West, L. J., Karamlou, T., Dipchand, A. I., Pollock ... Graft survival and patient mortality is approximately the same between ABOi and ABOc recipients. This was found to not only ... Furthermore, should the recipient (for example, type B-positive with a type AB-positive graft) require eventual ... Does ABO-incompatible and ABO-compatible neonatal heart transplant have equivalent survival? Interactive cardiovascular and ...
Within the last few years, 1-year graft and patient survival at more experienced centers have reached 60% to 70% and 65% to 80 ... Surgical removal (excision or debridement) of the damaged skin is followed by skin grafting. The grafting serves two purposes: ... Higher graft and patient survival rates are seen at the more experienced transplant programs. ... Bone grafting is used to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or ...
"VEGF-trap Aflibercept Significantly Improves Long-term Graft Survival in High-risk Corneal Transplantation". Transplantation. ... Fuchsluger, T. A.; Jurkunas, U.; Kazlauskas, A.; Dana, R. (2011). "Anti-apoptotic gene therapy prolongs survival of corneal ... Class II-positive Dendritic Cells Derived from MHC Class II-negative Grafts". The Journal of Experimental Medicine. 195 (2): ... "Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment". The ...
Mehta V, Hong M, Spears J, Mendez I (June 1998). "Enhancement of graft survival and sensorimotor behavioral recovery in rats ... derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells". Neuroscience. 83 (2): 363-372 ... was translated into clinical trials in patients with Parkinson's disease and showed long-term survival of those grafts. He also ... He pioneered the technique of multiple grafts to restore dopamine input to the parkinsonian mammalian brain. This technique ...
1983) Grafting of burn patients with allografts of cultured epidermal cells. Lancet 2(8347): 428-430 (PMID 6135914) Halebian PH ... Corder VJ, Madden MR et al.. (1986) Improved burn center survival of patients with toxic epidermal necrolysis managed without ... 1983) Grafting of burn patients with allografts of cultured epidermal cells. Lancet 2(8347): 428-430 (PMID 6135914) Halebian PH ...
At one-year, graft survival rates for isolated intestine currently waver around 80%, and 70% for intestine-liver and ... In a multivisceral graft, the stomach, duodenum, pancreas, and/or colon may be included in the graft. Multivisceral grafts are ... In the most basic and common graft, an isolated intestinal graft, only sections of the jejunum and ileum are transplanted. ... There are three major types of intestine transplants: an isolated intestinal graft, a combined intestinal-liver graft, and a ...
Graft survival and people's mortality is approximately the same between ABOi and ABO-compatible (ABOc) recipients. While focus ... Renal transplantation is more successful, with similar long-term graft survival rates to ABOc transplants. Until recently, ... Among his advances was the tubed pedicle graft, which maintained a flesh connection from the donor site until the graft ... allografts have been shown to have significantly lower graft survival than those from donation-after-brain-death (DBD) ...
Graft survival and patient mortality is approximately the same between ABOi and ABO-compatible (ABOc) recipients. While focus ... Kidney transplantation is more successful, with similar long-term graft survival rates to ABOc transplants. Rejection is an ... Graft-versus-host disease Graft-versus-tumor effect Immunosuppression Transplant engineering Frohn C, Fricke L, Puchta JC, ... There is a risk of graft-versus-host disease (GVHD), however, whereby mature lymphocytes entering with marrow recognize the new ...
January 1986). "Influence of the internal-mammary-artery graft on 10-year survival and other cardiac events". The New England ... with graft patency of 92% for all grafts and 100% for left internal thoracic artery grafts. Coronary artery bypass graft ... August 1989). "Internal mammary artery bypass grafting: influence on recurrent angina and survival in 2,100 patients". The ... Assessing survival and adverse cardiac events up to 8.0 years (average 2.9±2.0 years), MICS CABG is a safe, reproducible ...
Graft survival and patient mortality is approximately the same between ABOi and ABO-compatible (ABOc) recipients.[4] While ... with similar long-term graft survival rates to ABOc transplants.[7] Immunologic mechanisms of rejection[edit]. Rejection is an ... "Host-versus-graft disease" redirects here. For the condition in which transplanted cells attack the recipient's cells, see ... Chronic rejection explains long-term morbidity in most lung-transplant recipients,[14][15] the median survival roughly 4.7 ...
T Davis and Joseph Pagkalos, published a paper on the effects of bearing surfaces on the survival of cementless and hybrid ... Peptide Enhanced Bone Graft. In 2020, Dr. Kopjar, along with Drs. Edward. ... "Predictive factors of survival in a surgical series of metastatic epidural spinal cord compression and complete external ... "Survival and Clinical Outcomes in Surgically Treated Patients With Metastatic Epidural Spinal Cord Compression: Results of the ...
Graff 2015, p. 174. Peteet 1996, pp. 139-159. Ala Alazzeh, 'Abu Ahmad and His Handalas,' in Mark LeVine, Gershon Shafir (eds ... Struggle and Survival in Palestine/Israel, University of California Press 2012 pp.413-427 pp.424-5. Marouf Hasian and Lisa A. ... James A. Graff, in Tomis Kapitan (ed.), Philosophical Perspectives on the Israeli-Palestinian Conflict, M.E. Sharpe, 1997 pp. ... James A. Graff, 'Targeting Children,' in Tomis Kapitan (ed) Philosophical Perspectives on the Israeli-Palestinian Conflict, M.E ...
... necklace graft'). AV fistulas have a much better access patency and survival than do venous catheters or grafts. They also ... More options for sites to place a graft are available, because the graft can be made quite long. Thus a graft can be placed in ... AV grafts are at high risk to develop narrowing, especially in the vein just downstream from where the graft has been sewn to ... or a synthetic graft. In the latter two, needles are used to puncture the graft or fistula each time dialysis is performed. The ...
... long-term survival). Good matching of these antigens between host and donor is most critical for achieving graft survival. HLA- ... Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A ( ... were originally defined as cell surface antigens that mediate graft-versus-host disease. Identification of these antigens has ...
Graft-versus-tumor effect[edit]. Main article: Graft-versus-tumor effect. Graft-versus-tumor effect (GVT), or "graft versus ... As survival following the procedure has increased, its use has expanded beyond cancer to autoimmune diseases[4][5] and ... Graft-versus-host disease[edit]. Main article: Graft-versus-host disease. Graft-versus-host disease (GVHD) is an inflammatory ... increase the risk of graft rejection. A mismatch of an HLA type II gene (i.e. HLA-DR or HLA-DQB1) increases the risk of graft- ...
Anti-PD-L1 peptide improves survival in sepsis. The Journal of Surgical Research. February 2017, 208: 33-39. PMC 5535083. PMID ... Exhaustive differentiation of alloreactive CD8+ T cells: critical for determination of graft acceptance or rejection (PDF). ...
... indicating that Medicaid accessibility led to early detection of breast cancer and higher survival rates.[111] ... implants and grafts.[78] ...
Survival rates[edit]. Although the one-year survival rate of transplanted hands has been excellent at institutions that are ... Medical grafting. *Bone grafting. *Skin grafting. *Vascular grafting. Organ donation. *Non-heart-beating donation ...
Wilson RS, Barral S, Lee JH, Leurgans SE, Foroud TM, Sweet RA, Graff-Radford N, Bird TD, Mayeux R, Bennett DA. Heritability of ... Todd, S; Barr, S; Roberts, M; Passmore, AP (November 2013). "Survival in dementia and predictors of mortality: a review.". ...
After the graft is taken, another graft will be used to cover the arm (resulting in a secondary scar). ... As advancements in the design and manufacturing process of the IPP improved its mechanical survival infection has emerged as ... The graft is dissected to expose the veins and antebrachial cutaneous nerves. (the latter done carefully for later reattachment ... Skin grafted muscle flaps have fallen from popularity. This procedure is a minimum of 3 steps and involves implantation of an ...
John 'Lofty' Wiseman SAS Survival Handbook, Revised Edition p. 240; William Morrow Paperbacks (2009) ISBN 978-1875900060 ... The numerous hybrids are propagated mainly by grafting on to seedling rootstock. While plants grown from seed are more likely ...
... the co-culture of OECs and NSPCs shows greater cell survival compared to the cell survival of NSPCs cultured alone. The results ... Transplantation of stem cells is also known to cause toxicity and graft-versus-host disease (GVHD). Apoptotic cells have been ... Another current issue with the survival of the cells is utilizing the proper biomaterials to deliver them to the site of the ... as cell survival is usually less than 1% after transplantation.[3] The inability of these cells to sustain after ...
Eventually both tissue systems become grafted or integrated and a plant with the characteristics of the grafted plant develops ... In a sense, this process is not one of reproduction but one of survival and expansion of biomass of the individual. When an ... Grafting[25]Edit. A scion, or a desired cutting, is attached to the stem of another plant that remains rooted in the ground. ... "Kumar, G. (2011). "Propagation of Plants by Grafting and Budding" (PDF). Pacific Northwest Extension. pp. 3-5" (PDF).. ...
For example, studies in mice bearing human skin grafts found a reduction in the size of lesions from psoriasis after treatment ... "Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma". Blood. 109 (5): 2100-5. ...
Outcome studies on modern designs show a five-year implant survival rate between 67% and 94%.[7][8][9] and ten-year survival ... The outcome of an ankle replacement includes factors like ankle function, pain, revision and implant survival. ... rates around 75%.[7] Mobile bearing designs have enabled implant survival rates to continue to improve, reaching as high as 95 ...
Further anti-tumor activity is mediated through the inhibition of apoptosis protein-2 and pro-survival effects of IGF-1, ... Orphan indications by the FDA include graft-versus-host disease, mycobacterial infection, recurrent aphthous ulcers, severe ... Osteoclasts become highly active during MM, leading to bone resorption and secretion of various MM survival factors. They ...
The cancer chemotherapic docetaxel has been used as treatment for CRPC with a median survival benefit of 2 to 3 months.[116][ ... and AR into isolated samples of basal and luminal cells and grafted the treated tissue into mice. After 16 weeks, none of the ... In the United States, prostate cancer that is local or regional at the time of diagnosis has a 5-year survival rate of nearly ... Sipuleucel-T, a cancer vaccine has been found to result in a benefit (a four-month increase in survival) for men with ...
This kind of dwarfing can be attained through selective breeding, genetic engineering, or more often, scions are grafted on to ... In this case, the emphasis was on selecting for survival and reproduction, not size. ...
Children: 90% five-year survival rate[2]. Adults: 35% five-year survival[7]. ... The evidence is very uncertain about the therapeutic effect of mesenchymal stromal cells to treat graft-versus-host diseases ... Survival for children increased from under 10% in the 1960s to 90% in 2015.[2] Survival rates remain lower for babies (50%)[14] ... "Prognosis and survival for acute lymphocytic leukemia - Canadian Cance". www.cancer.ca. Retrieved 6 December 2017.. ...
"Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice". ...
... with ever-increasing survival rates. During his last eight years in active practice, Koop never lost a full-term baby upon whom ... such as the colon interposition graft for correcting esophageal atresia (congenital lack of continuity of the esophagus) or ... "Atresia of the Esophagus: Increased Survival with Staged Procedures in the Poor-risk Infant". Annals of Surgery. 162 (3): 389- ...
The interconnections are made by the inosculation process, a kind of natural grafting or welding of vegetal tissues. The tests ... They are also used for reproduction, defence, survival, energy storage and many other purposes. The radicle or embryonic root ... Most artists use grafting of living trunks, branches, and roots, for art or functional structures and there are plans to grow " ...
Adler, C.J.; Haak, W.; Donlon, D.; Cooper, A. (2010). "Survival and recovery of DNA from ancient teeth and bones". Journal of ... Lateral pedicle graft. *Pocket reduction surgery. *Socket preservation. *Sinus lift. *Subepithelial connective tissue graft ...
The 6-year leukemia-free survival (LFS) and overall survival (OS) rates were 84.4% and 89.5%, respectively, in the low-risk ... Practices of microtransplantation has shown none graft-versus-host disease (GVHD) till present, thus immunosuppressive drugs ... No graft-versus-host disease was observed in any patient. Persistent donor microchimerism was successfully detected in all of ... graft-versus-tumor (GVT) effect. Donor's stem cells, which have been processed, will also accelerate functional recovery of ...
Spencer believed the survival of the fittest could and should be applied to commerce and human societies as a whole. ... Skin grafts between non-related cheetahs illustrate this point: there is no rejection of the donor skin. ... survival), whereas the outcrossing population showed no decline. This is one of a number of studies that show sexuality to have ...
Gemmules are "survival pods" which a few marine sponges and many freshwater species produce by the thousands when dying and ... However they reject grafts from other species but accept them from other members of their own species. In a few marine species ... "survival pods" of unspecialized cells that remain dormant until conditions improve and then either form completely new sponges ...
Enhanced grafting of adoptively transferred, tumor-reactive effector T cells by the creation of an immunologic space niche. ... August 1995). "Effects of cyclophosphamide on the development of malignancy and on long-term survival of patients with ...
... allowing survival on a diet of tsamma for six weeks.[12] ... Grafting such varieties onto disease-resistant rootstocks ...
To ensure survival it may be necessary to pot the tree and grow it in a greenhouse for its first winter. It may be reintroduced ... Zelkova Serrata is propagated by seeds, rooted stem cuttings and grafting. The seeds germinate without pretreatment, though the ...
EGF is used to modify synthetic scaffolds for manufacturing of bioengineered grafts by emulsion electrospinning or surface ... EGF, via binding to its cognate receptor, results in cellular proliferation, differentiation, and survival.[9] ...
For seed multiplication, grafting would work.[46] Normal tree growth requires 6, 7, or even 8 years before a chestnut will ... Some of these sites have had researchers check on the saplings that have been planted to see their survival rate. For the ... so not all restoration areas have been successful with hybrid survival. ...
The embryonic stem cells were shown to have a better survival rate in the tendon as well as better migrating capabilities to ... Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs- ... leading to graft vs host disease, the most serious side effect of this treatment.[5] ... "New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease". Mediators Inflamm. 2014: 701013. doi ...
Antigens of phagocytosed graft cells can also be presented by the host's class I MHC molecules to CD8+ T cells.[1][29] ... If hyperacute and acute vascular rejection are avoided accommodation is possible, which is the survival of the xenograft ... The graft was meant to be temporary, but unfortunately a suitable allograft replacement could not be found in time. While the ... The graft is given a break from humoral rejection[28] when the complement cascade is interrupted, circulating antibodies are ...
"Development and Validation of a Model Predicting Graft Survival After Liver Transplantation." Liver Transpl 12:1594-1606, 2006. ... Nine characteristics of the recipients were also associated with graft survival in the multivariate model:. ... in which survival as predicted by the model was compared with the observed survival among patients whose data were not used to ... to receive the donor with better predicted survival and vice versa, since that would make the posttransplant survival of the ...
Lipotoxicity and Decreased Islet Graft Survival. Cristiane B Leitão, Karina Bernetti, Thipaporn Tharavanij, Pablo Cure, ... Lipotoxicity and Decreased Islet Graft Survival. Cristiane B Leitão, Karina Bernetti, Thipaporn Tharavanij, Pablo Cure, ... Lipotoxicity and Decreased Islet Graft Survival. Cristiane B Leitão, Karina Bernetti, Thipaporn Tharavanij, Pablo Cure, ... Aim: To evaluate if baseline serum lipids are associated with islet graft survival in type 1 diabetes mellitus islet transplant ...
B cell survival holds key to chronic graft vs. host disease. University of North Carolina Health Care ... In chronic Graft vs. Host Disease (GVHD), the differences between the donor bone marrow cells and the recipients body often ... Low-dose treatment with Il2 across studies shows benefits in chronic graft-versus host Dana-Farber Cancer Institute ... and ultimately affect their long-term survival. ... B cell survival holds key to chronic graft vs. host disease ...
Rabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival. ... Rabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival. ... 0.007) IgGs in late post-graft samples compared with SSD- recipients.. CONCLUSION.. In conclusion, our data indicate that SSD ... We analyzed data from a cohort of 889 first kidney graft recipients with ATG induction (86 with SSD [SSD+] and 803 without SSD ...
Graft Survival and Healing. The ultimate success of a skin graft, or its "take," depends on nutrient uptake and vascular ... Smaller grafts can be taken using a "pinch graft" technique using a scalpel blade; slightly larger freehand grafts can be ... Cadaveric grafts and porcine grafts are skin substitutes that have been used clinically for several decades. Cadaveric grafts ... a well vascularized recipient bed is of utmost importance in survival of the skin graft. With some exceptions, skin grafts ...
A simplified index to help predict five-year survival after a liver transplant isolated five comorbidities germane to these ... There may also be unmeasured variations in graft quality or the quality of clinical care. This study was limited by the fact ... The updated index improved the likelihood ratio chi-squared value from 15 to 24 for predicting post-transplant survival at five ... Explain to interested patients that there are several methods for predicting survival after a liver transplant, and that a ...
... and delayed graft function (P,0.0001). Donor vascular disease is an independent risk factor for suboptimal graft survival. ... Correlation of histologic findings on preimplant biopsy with kidney graft survival Transpl Int. 2008 Sep;21(9):892-8. doi: ... and did not have a demonstrable effect on graft outcome. Clinical parameters independently associated with worse graft function ... Increasing degrees of glomerulosclerosis (GS) were associated with earlier graft failure on univariate (P=0.03) but not ...
... anti-OX40L increased the mean graft survival time from 5.2 days (control group) to 42.5 days (p < 0.05). None of the grafts in ... An immunotherapeutic strategy for prolonging graft survival in mice.. [Feng Wang, Jun Li, Dong Wang, Qian Fu, Yun-Yi Xiong, Hui ... The percentage of regulatory T cells was the highest in the recipients with long-term graft survival. The combination of donor- ... Here, we assess the effects of a novel immunosuppressive strategy on graft survival and host immune response. Alloantigen ...
Survival of Grafted Cardiomyocytes. Figure 1⇓ summarizes the survival pattern of fetal, neonatal, and adult cardiomyocytes ... Survival of cardiomyocyte grafts. Fetal, neonatal, or adult rat cardiomyocytes were grafted into normal myocardium, acutely ... Inset in D, Anti-BrdU and eosin staining of graft area 8 weeks after grafting. BrdU-positive graft neonatal cardiomyocytes were ... how developmental stage influences graft survival; (2) whether acutely necrotic or healing cardiac lesions support grafts; and ...
... have impacted the outcomes of children with severe acute graft-versus-host-disease. ... Significant strides have been made in the survival rates of pediatric patients with grade 3 steroid-refractory acute graft- ... Berger M, Pessolano R, Carraro F, Saglio F, Vassallo E, Fagioli F. Steroid-refractory acute graft-versus-host disease graded ... According to the researchers, there are various factors that can explain the marked increase in survival among these patients, ...
Although DWGF is a major cause of graft loss, the risk has declined substantially since 1990. Cardiovascular disease was the ... Patients with graft function have a high long-term survival. ... 5% of all graft loss. Patient survival with graft function was ... Long-term survival in renal transplant recipients with graft function. Background: Death with graft function (DWGF) is a common ... Conclusions: Patients with graft function have a high long-term survival. Although DWGF is a major cause of graft loss, the ...
Ten-year follow-up of graft survival and visual outcome after penetrating keratoplasty in Sweden.. Claesson M1, Armitage WJ. ... Graft survival and visual outcome at 10 years depended on indication and postoperative complications. Most improvement of ... Multiple regression analyses (logistic and linear) were performed on graft survival and visual outcome (visual acuity and ... To determine factors influencing graft survival and visual outcome 10 years after penetrating keratoplasty. ...
Home , February 2013 - Volume 131 - Issue 2 , Discussion: The Volumetric Analysis of Fat Graft Survival i... ... Discussion: The Volumetric Analysis of Fat Graft Survival in Breast Reconstruction Plastic and Reconstructive Surgery131(2):192 ... Discussion: The Volumetric Analysis of Fat Graft Survival in Breast Reconstruction. Rigotti, Gino M.D. ... Brava and Autologous Fat Grafting for Breast Reconstruction after Cancer Surgery * Megavolume Autologous Fat Transfer: Part I. ...
... by Medindia Content Team on June 21, 2005 at 2:39 PM General ... The new procedure of total grafting of arteries will reduce the risk and is expected to increase the rate of survival of the ... Incomplete artery grafting may not increase the lifespan of the patients sufficiently outside the hospital stay.. ... found that patients who had blockages in multiple of coronary arteries have more life span when they undergo arterial grafts ...
... enabling localized therapy in patients receiving a tissue graft transplant of the leg, hand or face. ... 13 edition of Science Translational Medicine, median graft survival was more than 100 days in rats treated with the tacrolimus ... Vascularized composite allotransplantation is the current paradigm to ensure graft survival, but involves chronic ... This new approach to delivering immunosuppressant therapy suggests that local delivery of the drug to the grafted tissue has ...
Patient and Graft Survival. Twenty-seven patients died during the 7-year study period. Progressive graft failure was the main ... and anti-MICA antibodies did not significantly correlate with 7-year graft survival or acute graft rejection in either early or ... Figure 3: Survival of patients in anti-MICA positive and anti-MICA negative groups. Graft loss occurred in 8 patients in anti- ... Figure 2: Survival of patients in anti-HLA positive and anti-HLA negative groups. Graft loss occurred in 7 (23%) patients in ...
... in donor corneas can enhance graft survival in corneal allograft recipients with inflamed graft beds. Treatment of donor ... diminished graft infiltration of CD45+ and CD4+ cells, and significantly improved corneal allograft survival compared to saline ... In high-risk corneal transplantation, where the graft bed is inflamed and vascularized, immature APCs in the donor corneal ... The Kaplan-Meier survival curve was used to determine graft survival and Wilcoxon Rank test was used to compare survival rates ...
No primary graft failures occurred in either group. One-year graft survival rates were comparable (98% vs 97%) in the 5.0- and ... To assess the effect of incision width (5.0 and 3.2 mm) on graft survival and endothelial cell loss 6 months and 1 year after ... Effect of incision width on graft survival and endothelial cell loss after Descemet stripping automated endothelial ... This retrospective analysis assessed graft survival, complications, and endothelial cell loss, which was calculated from ...
Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysis.. ... Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysis. ... Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysis. ... Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysis. ...
2004). Impact of body mass index on graft failure and overall survival following liver transplant. Clinical Transplantation, 18 ... Impact of body mass index on graft failure and overall survival following liver transplant. ... on graft failure rates and overall survival rates are assessed using proportional hazards regression. RESULTS: Controlling for ... CONCLUSION: BMI did not significantly affect rates of graft failure. Compared with patients with a BMI in the normal range, ...
African ancestry did not shorten duration of graft survival. ... Donor Genes, Not Race, Affect Graft Survival Delicia Honen Yard ... Eight (32%) of the 25 grafts that failed over a mean 24.6 months of follow-up had two APOL1 risk variants, researchers reported ... in the American Journal of Graft Transplantation (2011;11:1025-1030). Overall, ...
Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft ... Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft ... Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft ... Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft ...
... before grafting to test whether allograft survival could be favorably affected in comparison with untreated corneas grafted ... These data suggest that UV-B pretreatment of donor corneal endothelium prolongs graft survival but that toxic side effects must ... "Low-dose ultraviolet-B irradiation of donor corneal endothelium and graft survival." Investigative Ophthalmology & Visual ... Low-dose ultraviolet-B irradiation of donor corneal endothelium and graft survival. ...
"These findings suggest that adopting a Mediterranean diet may benefit kidney graft survival after kidney transplantation, ... Close more info about Mediterranean Diet Tied With Better Renal Graft Survival ... Close more info about Mediterranean Diet Tied With Better Renal Graft Survival ... 76 patients experienced graft failure, 119 kidney function decline (doubling of serum creatinine or graft failure), and 181 ...
Next Document: Mycophenolate mofetil use is associated with prolonged graft survival after kidney transplantation.. ... Because kidney allograft survival is closely related to BP levels, we investigated the impact of early high PP, systolic, ... Moreover, PP emerged as the strongest BP component influencing overall and death-censored kidney allograft survival. CONCLUSION ... Previous Document: Rapamycin for refractory acute graft-versus-host disease.. ...
S. G. Holtan, T. E. DeFor, A. Lazaryan et al., "Composite end point of graft-versus-host disease-free, relapse-free survival ... Prognostic Factors on the Graft-versus-Host Disease-Free and Relapse-Free Survival after Adult Allogeneic Hematopoietic Stem ... A. Jalali, K. Alimoghaddam, M. Mahmoudi et al., "The EBMT risk score in the presence of graft versus host disease in allogeneic ... J. Bolanos-Meade, J. Koreth, and R. Reshef, "A multicenter phase II trial randomizing novel approaches for graft-versus-host ...
2 arterial grafts), there was ≥1 vein graft used in 87% of patients, and these vein grafts were subject to early thrombosis. ... The Impact of Preoperative Thrombolysis on Long-Term Survival After Coronary Artery Bypass Grafting. Ioannis K. Toumpoulis, ... The Impact of Preoperative Thrombolysis on Long-Term Survival After Coronary Artery Bypass Grafting ... The Impact of Preoperative Thrombolysis on Long-Term Survival After Coronary Artery Bypass Grafting ...
... Timisoara Romania Date September 26, 2013 ... Improving the patient and graft survival in kidney transplantation - an update *Oktoberfest-Satellite ERA/EDTA CME course " ... Improving the patient and graft survival in kidney transplantation - an update *Oktoberfest-Satellite ERA/EDTA CME course " ...
... the graft survival difference between treated and control mice was markedly increased. Median survival was 46 days for the MR1 ... long-term graft survival (, 100 days) was achieved in MR1-treated mice, whereas control recipients rejected their grafts within ... Graft survival in the MR1-treated group was significantly longer than in the Ha4/8-treated recipients (P = 0.00067) or in the ... Prolonged Islet Graft Survival in NOD Mice by Blockade of the CD40-CD154 Pathway of T-Cell Costimulation. ...
Keywords : Kidney Transplantation; Delayed Graft Function; Graft Survival; Survival Analysis; Graft Rejection. ... lower graft function up to six years after transplantation and lower death-censored graft survival at 1 and 5 years (P , 0.05 ... HELFER, Mateus Swarovsky et al. Long-term effects of delayed graft function duration on function and survival of deceased donor ... The occurrence of DGF has a long-lasting detrimental impact on graft function and survival and this impact is even more ...
  • The approach may allow for more accurate assessment of post-transplant survival than the MELD (Model End-Stage Liver Disease) score used by the United Network for Organ Sharing, and could help in allocation decisions, particularly in the case of marginal donors or recipients, Dr. Ioannou wrote. (medpagetoday.com)
  • If two donors are expected to be available at approximately the same time, it would be more equitable for the recipient with worse predicted posttransplant survival (as determined by the models presented here) to receive the donor with better predicted survival and vice versa, since that would make the posttransplant survival of the two recipients more similar," he continued. (medpagetoday.com)
  • To evaluate if baseline serum lipids are associated with islet graft survival in type 1 diabetes mellitus islet transplant (ITx) recipients. (diabetesjournals.org)
  • We analyzed data from a cohort of 889 first kidney graft recipients with ATG induction (86 with SSD [SSD + ] and 803 without SSD [SSD - ]) from the Données Informatisées et Validées en Transplantation data bank. (jci.org)
  • Moreover, SSD + patients exhibited significantly elevated titers of anti-ATG ( P = 0.043) and anti-Neu5Gc ( P = 0.007) IgGs in late post-graft samples compared with SSD - recipients. (jci.org)
  • The percentage of regulatory T cells was the highest in the recipients with long-term graft survival. (sigmaaldrich.com)
  • In this study, using a mouse model of corneal transplantation, we investigated whether enrichment of tolerogenic APCs (tolAPCs) in donor corneas can enhance graft survival in corneal allograft recipients with inflamed graft beds. (nature.com)
  • In high-risk corneal allograft recipients with inflamed and vascularized graft beds, corneal transplants have survival rates of 50% or lower even after treatment with corticosteroids. (nature.com)
  • In a recent study we have shown that ex vivo treatment of donor-type bone marrow-derived dendritic cells (BMDCs) with immunomodulatory cytokines (IL-10, TGFβ1) renders them tolerogenic, and when systemically transferred to corneal transplant recipients significantly improves allograft survival 19 . (nature.com)
  • Graft survival has improved significantly among recipients of kidneys from living donors despite increased recipient and donor age and less biological relatedness, researchers reported at the 2017 American Transplant Congress in Chicago. (renalandurologynews.com)
  • Donor rabbit corneal endothelium was pretreated with different doses of ultraviolet (UV-B) irradiation (302 nm) before grafting to test whether allograft survival could be favorably affected in comparison with untreated corneas grafted into the same recipients. (harvard.edu)
  • 100 days) was achieved in MR1-treated mice, whereas control recipients rejected their grafts within 25 days. (diabetesjournals.org)
  • Maintenance of the immunosuppressive balance is critical for allograft patency, minimization of adverse effects, and ultimately long-term survival of solid organ transplant recipients. (nih.gov)
  • Of the whole population of 1060 kidney recipients included in the statistical analysis, 938 (88.4%) had received a first kidney graft, 62% were male recipients with a mean age of 45.6 ± 13.1 years, and 68% were male donors with a mean age of 39.8 ± 15.3 years. (asnjournals.org)
  • Treating 100 recipients with tacrolimus instead of cyclosporin would avoid 12 suffering acute rejection, two losing their graft but cause an extra five to become insulin-requiring diabetics. (cochrane.org)
  • At six months graft loss was significantly reduced in tacrolimus-treated recipients (RR 0.56, 95% CI 0.36 to 0.86), and this effect was persistent up to three years. (cochrane.org)
  • In this prospective study we characterized graft composition of T- and NK cell subsets in 88 recipients of peripheral blood stem cell grafts with multicolor flowcytometry. (frontiersin.org)
  • Survival rates in recipients with FED, PBK and 'all other indications' were 95%, 83% and 89%, respectively. (bmj.com)
  • However, pediatric patients comprised the majority of bone marrow graft recipients in that study. (haematologica.org)
  • Likewise, skin graft rejection was significantly delayed in older recipients and fewer graft infiltrating CD4+T-cells were observed. (harvard.edu)
  • Old untreated recipients displayed a prolonged skin graft survival compared to their young counterparts, an observation that confirmed data of our previous experiments. (ovid.com)
  • Rapamycin led to a significant prolongation of graft survival in both young and old recipients. (ovid.com)
  • However, graft survival was age-dependent and extended in old versus young recipients (19 days vs 12 days, P = 0.004). (ovid.com)
  • We evaluated the role of thrombocytopenia and poor graft function in allogeneic stem cell recipients receiving ICU treatments along with established prognostic ICU markers in order to identify patients at risk for severe complications. (springer.com)
  • In a large study of U.S. kidney transplant recipients, five-year graft and patient survival were significantly lower in recipients with an HCV-positive kidney donor. (thebodypro.com)
  • To address the question of whether the limited supply of donors for patients needing kidney transplant could be alleviated by using more kidneys from deceased donors who had HCV infection, U.S. researchers looked at whether that strategy poses a risk of lower transplant survival or greater mortality in HCV-negative transplant recipients. (thebodypro.com)
  • A Virginia Commonwealth University team analyzed the national Organ Procurement and Transplant Network (OPTN) database to compare graft and patient survival in HCV-negative recipients of kidneys from HCV-positive versus negative donors. (thebodypro.com)
  • Lack of five-year graft and survival difference between HCV antibody-positive and negative recipients suggested to the researchers that "HCV transmission might not be the primary culprit" for the poor overall graft and patient survival in HCV D+/R- participants. (thebodypro.com)
  • Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors. (harvard.edu)
  • Persistent shortage and heterogeneous quality of liver grafts encourages the optimization of donor-recipient matching in liver transplantation (LT). We explored whether or not there was a survival benefit (SB) of LT according to the quality of grafts assessed by the Donor Quality Index (DQI) and recipients' disease severity, using the Model for End-Stage Liver Disease (MELD) in 8387 French patients wait-listed between 2009 and 2014. (inserm.fr)
  • Two groups were compared: 116 recipients grafted with a negative B-FCXM vs a group of 19 patients grafted with a positive B-FCXM. (oup.com)
  • The current one-year graft survival rate for pediatric renal transplant recipients is about 95% for deceased and living donor transplants alike (USRDS, 2015). (thefreedictionary.com)
  • Cotter TG, Paul S, Sandikçi B, Couri T, Bodzin AS, Little EC, Sundaram V, Charlton M. Improved Graft Survival After Liver Transplantation for Recipients With Hepatitis C Virus in the Direct-Acting Antiviral Era. (uchicago.edu)
  • Their use in kidney transplant recipients (KTRs) was aiming mainly to avoid early AR historically known to predict graft loss 3 , in patients suffering from delayed graft function (DGF) 4 and in many immunosuppression protocols used to avoid or to minimize calcineurin inhibitors (CNIs) 5 based immunosuppression therapy. (sciepub.com)
  • RESULTS: Patient survival at 5 years was better for recipients of grafts from related than unrelated donors (97% vs. 93%, P=0.0002), but conversely graft survival was better in recipients of genetically unrelated grafts (93% vs. 89%, P=0.06). (ox.ac.uk)
  • Poorer graft survival was independently associated with donor age older than 59 years, and female recipients. (ox.ac.uk)
  • From 1991 to 2018, 43 allogeneic SCT recipients were enrolled in the study to investigate the demographic characteristics, survival outcomes and prognostic factors. (bvsalud.org)
  • A recent report illustrates how advances in allogeneic hematopoietic stem cell transplantation (HSCT) have impacted the outcomes of children with severe acute graft-versus-host-disease. (ajmc.com)
  • Presence of donor specific anti-HLA antibodies (DSA) is a negative predictor of graft survival in kidney transplantation. (hindawi.com)
  • Antibody mediated rejection (AMR) of liver graft has not been considered an important pathology in ABO compatible, cross-match negative liver transplantation for many years. (hindawi.com)
  • In high-risk corneal transplantation, where the graft bed is inflamed and vascularized, immature APCs in the donor corneal stroma quickly mature and migrate to lymphoid tissues to sensitize host T cells. (nature.com)
  • Transplantation of these tolAPC-enriched corneas decreased frequencies of interferon gamma (IFNγ) + effector T cells (Teffs), as well as allosensitization in the hosts, diminished graft infiltration of CD45 + and CD4 + cells, and significantly improved corneal allograft survival compared to saline-injected controls. (nature.com)
  • Allogeneic transplantation across a major histocompatibility barrier of islets initially treated in vitro with ultraviolet irradiation resulted in prolonged allograft survival without the use of any immunosuppressive agents. (sciencemag.org)
  • Mycophenolate mofetil use is associated with prolonged graft survival after kidney transplantation. (biomedsearch.com)
  • We explored the transplantation of C57BL/6 islets into spontaneously diabetic NOD mice, a combination in which both allogeneic and autoimmune components are implicated in graft loss. (diabetesjournals.org)
  • Blockade of the CD28-B7 interaction by CTLA4-Ig prolonged graft survival in various models of organ allotransplantation ( 6 ), as well as in xenogeneic human-to-mouse and allogeneic nonhuman primate islet transplantation models ( 7 , 8 ). (diabetesjournals.org)
  • The interest in anti-CD154 therapy in islet transplantation has been enhanced by its described ability to prevent the release of nonspecific inflammatory mediators ( 11 , 12 ), a phenomenon likely to be involved in early islet graft loss. (diabetesjournals.org)
  • Delayed graft function (DGF) is a frequent complication after deceased donor kidney transplantation with an impact on the prognosis of the transplant. (scielo.br)
  • Despite this, long-term impact of DGF on graft function after deceased donor kidney transplantation has not been properly evaluated. (scielo.br)
  • RESULTS- Treatment of NOD mice with MK0431 before and after islet transplantation resulted in prolongation of islet graft survival, whereas treatment after transplantation alone resulted in small beneficial effects compared with nontreated controls. (diabetesjournals.org)
  • Survival after solid organ transplantation has increased substantially due in part to the broad clinical use of immunosuppressants. (nih.gov)
  • The effect of combination splenectomy and low-dose FK506 therapy on graft survival after liver allograft transplantation in rats. (biomedsearch.com)
  • The effect of splenectomy on allograft survival was investigated using orthotopic liver transplantation in a rat experimental model (ACI rat liver grafted to LEW rat). (biomedsearch.com)
  • In conclusion, incompatibility between graft and recipient weight is an independent predictor of long-term graft survival, suggesting that avoiding kidney and recipient weight incompatibility may improve late clinical outcome after kidney transplantation. (asnjournals.org)
  • The effect of nephron reduction has long been described in animal models as well as in humans 1 , 2 and is thought to be a potential "nonimmunologic" risk factor for chronic graft dysfunction after kidney transplantation. (asnjournals.org)
  • Strategies to increase donor organ availability and to prolong the transplanted kidney's survival have become priorities in kidney transplantation. (cochrane.org)
  • Mature immunocompetent cells from the stem cell graft as well as early robust immune reconstitution are essential for the graft-vs. -tumor (GVT) effect to eliminate residual malignant cells after allogeneic hematopoietic stem cell transplantation (HSCT). (frontiersin.org)
  • Our primary aim was to analyze the impact of graft composition on immune reconstitution and clinical outcomes after transplantation. (frontiersin.org)
  • The results suggest a protective effect of high doses of NK cells in grafts and during early immune reconstitution and support the perception of NK cells as innate effector cells with anti-tumor effects in the setting of allogeneic stem cell transplantation. (frontiersin.org)
  • Although allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for various hematologic malignancies, it is still a procedure associated with a substantial risk of disease relapse and transplant-related morbidity and mortality (TRM) including graft-vs.-host disease (GVHD) ( 1 - 3 ). (frontiersin.org)
  • However, graft contents and immune recovery of T cells do not always reflect outcomes after transplantation ( 11 - 14 ). (frontiersin.org)
  • T cells in grafts serve an important role in the pathogenesis of graft versus host disease (GVHD) and immune recovery during HLA matched allogeneic stem cell transplantation. (unboundmedicine.com)
  • TY - JOUR T1 - High proportions of CD3+ T cells in grafts delayed lymphocyte recovery and reduced overall survival in haploidentical peripheral blood stem cell transplantation. (unboundmedicine.com)
  • We previously reported that bone marrow grafts from matched sibling donors resulted in best graft- versus -host disease-free, relapse-free survival at 1-year post allogeneic hematopoietic cell transplantation. (haematologica.org)
  • Disease relapse and graft- versus -host disease (GVHD) impact the length and quality of life after allogeneic hematopoietic cell transplantation (HCT). (haematologica.org)
  • In conclusion, efficient cytoreduction followed by donor-lymphocyte infusion and subsequent interferon-α leading to limited acute graft- versus -host-disease represents a potentially curative option for patients with relapsed acute myeloid leukemia after allogeneic transplantation. (haematologica.org)
  • Allogeneic stem cell transplantation (SCT) as treatment for patients with acute myeloid leukemia (AML) aims to combine high-dose chemotherapy with immunotherapy by donor T cells mediating a graft-versus-leukemia (GvL) response. (haematologica.org)
  • Moreover, DCD liver grafts are no longer eligible for transplantation after their warm ischaemic time exceeds 30 min. (springer.com)
  • In this study, we established an arterialized mouse non-heart-beating (NHB) liver transplantation model, and compared survival rates, cytokine and chemokine expression, histology, and the results of in vitro co-culture experiments in animals with or without MSC infusion. (springer.com)
  • MSCs markedly ameliorated NHB liver graft injury and improved survival post-transplantation. (springer.com)
  • Evidence-based medicine has demonstrated the relatively good quality and safety of DCD grafts with a warm ischaemic time of less than 30 min, and this criterion is implemented in transplantation centres worldwide. (springer.com)
  • For grafts with warm ischaemic time less than 30 min, the primary negative outcome of DCD liver transplantation is late ischaemic cholangiopathy rather than primary non-function, whereas for grafts with warm ischaemic time over 30 min, the primary negative outcome of DCD liver transplantation is early mortality. (springer.com)
  • Helfritz FA, Lehner F, Manns MP, Ciesek S, Klempnauer J (2015) Perioperative White Blood Cell Count as a Marker for Patient and Graft Survival after Orthotopic Liver Transplantation. (omicsonline.org)
  • Risk factors for acute GVHD and survival after hematopoietic cell transplantation. (scienceinpublic.com.au)
  • A cute graft-versus-host disease remains a major threat to a successful outcome after allogeneic hematopoietic cell transplantation. (jefferson.edu)
  • The objective of this study was to investigate the effects of donor-recipient HLA matching on graft survival in pediatric heart transplantation. (ahajournals.org)
  • Conclusions -Decreased graft loss in pediatric heart transplantation was associated with a higher degree of donor-recipient HLA matching, although a difference in the frequency of early rejection or development of coronary artery vasculopathy was not seen. (ahajournals.org)
  • Is HRQOL in dialysis associated with patient survival or graft function after kidney transplantation? (biomedcentral.com)
  • Whether HRQOL in dialysis can affect mortality or graft survival after renal transplantation (RTX) is not determined. (biomedcentral.com)
  • Risks factors for acute rejection were evaluated by logistic regression adjusting for transplant centre and transplantation year, while a Cox proportional hazard model was employed for analysing patient and graft survival. (oup.com)
  • What is the impact of human leukocyte antigen mismatching on graft survival and mortality in renal transplantation? (biomedcentral.com)
  • We aim to quantitatively assess the associations of HLA mismatching with graft survival and mortality in adult kidney transplantation. (biomedcentral.com)
  • Here, we sought to conduct a meta-analysis to assess the magnitude effect of HLA mismatching in adult kidney transplantation, with a particular focus on graft survival and recipient mortality. (biomedcentral.com)
  • Acute graft-versus-host disease (aGVHD) remains one of the main obstacles after allogeneic bone marrow transplantation (BMT). (uni-regensburg.de)
  • Cell survival was assessed in a gender-mismatched transplantation model. (onlinejacc.org)
  • The objective of this study was to determine the ten-year graft survival rate of renal transplantation and its contributing factors among a group of Iranian patients aged 18 years or younger. (thefreedictionary.com)
  • A prospective, randomized, multicenter study was conducted to compare G-BM with G-PBSC as the grafts in allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute leukemia in first complete remission (CR1). (biomedcentral.com)
  • Measurements: Actuarial survival rates for grafts and patients after transplantation, maximal nonrenal scores on the Systemic Lupus Erythematosus Disease Activity Index, and time-adjusted disease exacerbation rates in all patients before and after transplantation. (edu.au)
  • Secondary endpoints contain: the frequency and the type of infections and the surgical complications at 1 year as well as the amount of malignancy and the patient survival at 1, 6, 12 and 36 months after kidney transplantation. (sciepub.com)
  • Since its first successful attempt in 1954, kidney transplantation (KT) has witnessed tremendous progression in graft survival (GS), as well as acute rejection (AR) rate and severity. (sciepub.com)
  • To investigate the possibility of transplantation therapy to repair damaged inner ear, we have examined whether grafted fetal otocyst cells could survive and migrate into injured sensory organs. (mysciencework.com)
  • One month after transplantation, the grafted inner ear sensory organs were examined immunohistochemically. (mysciencework.com)
  • Factors affecting graft and patient survival after live donor kidney transplantation in the UK. (ox.ac.uk)
  • Increasing donor age (but not recipient age), recipient diabetes, and grafts from adult offspring were independently associated with poorer patient survival in the first 3 years after transplantation. (ox.ac.uk)
  • Beyond death and graft survival-Variation in outcomes after kidney transplantation. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Beyond death and graft survival-Variation in outcomes after kidney transplantation. (elsevier.com)
  • This study aimed to assess the outcome of stem cell transplantation (SCT), including overall survival (OS), failure-free survival (FFS) and graft-versus-host disease (GvHD)-free/failure-free survival (GFFS), and to analyze prognostic factors in children with aplastic anemia (AA). (bvsalud.org)
  • Graft-versus-host-disease-associated oral cancer may have more aggressive behavior with poorer prognosis, when compared to oral cancer in non-hematopoietic stem cell transplantation patients. (wikipedia.org)
  • The combination of donor-specific transfusion+rapamycin+anti-OX40L inhibits graft rejection mediated by memory cells and is likely to contribute to prolonged allograft survival. (sigmaaldrich.com)
  • No correlations were detected between presence of antibodies and acute graft rejection (AGR). (hindawi.com)
  • however, detection of any antibodies was correlated with episodes of late graft rejection. (hindawi.com)
  • There are conflicting data regarding impact of anti-MICA antibodies on acute rejection episodes and kidney graft survival [ 7 , 8 ]. (hindawi.com)
  • The 14th International HLA and Immunogenetics Workshop Prospective Chronic Rejection Project was an international collaborative study of 45 transplant centers to assess impact of anti-HLA and anti-MICA antibodies detected after transplant on chronic graft failure. (hindawi.com)
  • Although exposure of donor endothelium significantly reduced endothelial rejection at all doses tested, it resulted in primary graft failure in a substantial proportion of corneas treated at high doses. (harvard.edu)
  • Graft Rejection. (scielo.br)
  • The objective of this study is to conduct prospective clinical studies to investigate the impact of generic immunosuppressants on short term acute rejection and long term patient graft survival. (nih.gov)
  • The question whether the brand to generic switch or switch among multiple generic products may introduce clinically relevant changes in drug exposure and thus affect acute rejection, adverse events, and long term graft survival remains debated in transplant community. (nih.gov)
  • We evaluated whether different parameters of infection including inflammatory markers and white blood cells (WBC) predict post-OLT mortality, graft survival and rate of acute rejection. (omicsonline.org)
  • Patients were stratified by i) patient survival, ii) graft survival and iii) episode of rejection(s) and were followed from OLT for one year. (omicsonline.org)
  • This study analyzed graft survival for 220 pairs of cadaveric kidneys for the similarity of parameters reflecting function and rejection. (asnjournals.org)
  • In contrast, measures of rejection strongly affected survival but showed no pairing. (asnjournals.org)
  • In contrast, rejection affects survival and function, but it is not primarily determined by the characteristics of the donor tissue. (asnjournals.org)
  • In this study, we compared mate kidneys for the similarity of function (low urine output, dialysis dependency, serum creatinine [SCr]), as well as rejection and graft survival. (asnjournals.org)
  • Old patients have a low risk of acute rejection but a poorer death-censored graft survival. (oup.com)
  • See Graft rejection . (thefreedictionary.com)
  • Rael VE, Chen L, McIntosh CM, Alegre ML. Exercise increases skin graft resistance to rejection. (uchicago.edu)
  • The primary endpoints comprised the rate and the severity of acute rejection episodes as well as the 3-year graft function and survival. (sciepub.com)
  • We did not find any significant difference between the 2 groups regarding the length of hospital stay, the rate and severity of acute rejection, the rate of CMV infection, the occurrence of delayed graft function and the rate and type of surgical complications at 1 year. (sciepub.com)
  • For example, livers from African American and female donors were associated with significantly higher risk of graft failure, as were livers with cold ischemia time longer than 8.8 hours. (medpagetoday.com)
  • Thus, older and heavier donors, men, African Americans, patients with diabetes, and patients at the top of the UNOS urgency list were more likely in the model to have graft failure. (medpagetoday.com)
  • or=25% luminal compromise, was a significant predictor of graft outcome in standard criteria donors (multivariate, P=0.01) and in expanded criteria donors (ECD) as defined by UNOS criteria (univariate P=0.02). (nih.gov)
  • 300 patients and only in living donors, 22 , 23 where the graft does not incur the same accumulating injuries as those from deceased donors. (asnjournals.org)
  • Patients transplanted with graft NK cell doses above the median value of 27 × 10 6 /kg had significantly increased relapse-free-survival compared to patients transplanted with lower doses, HR 2.12 (95% CI 1.01-4.45, p = 0.04) Peripheral blood concentrations of NK cells obtained from donors before G-CSF mobilization were significantly correlated to graft NK cell doses (Spearman's ρ 0.53, p = 0.03). (frontiersin.org)
  • In adults, bone marrow from matched sibling donors (n=123) had best graft- versus -host disease-free, relapse-free survival at 1- and 2-years, compared with peripheral blood stem cell from matched sibling donors (n=540) or other graft/donor types. (haematologica.org)
  • In multivariate analysis, peripheral blood stem cells from matched sibling donors resulted in a 50% increased risk of events contributing to graft- versus -host disease-free, relapse-free survival at 1- and 2-years than bone marrow from matched sibling donors. (haematologica.org)
  • The pressure to use organs from marginal donors underscores the importance of understanding the influence of donor tissue quality or characteristics on graft outcomes ( 2 - 4 ). (asnjournals.org)
  • The increased survival of kidney allografts from living donors compared with cadaver allografts with similar HLA mismatches is probably related, at least in part, to injury from brain death ( 15 ). (asnjournals.org)
  • Using mismatched unrelated donors may increase the donor pool, but this type of transplant carries a high risk of graft-versus-host disease (GVHD) and severely impaired immune recovery. (nature.com)
  • Kling CE, Perkins JD, Biggins SW, Johnson CK, Limaye AP, Sibulesky L. Listing practices and graft utilization of hepatitis C-positive deceased donors in liver and kidney transplant. (uchicago.edu)
  • In the 10/10 HLA matched transplants (n=280), non-wild type (wt) donors showed a trend to increase the incidence of acute graft-versus-host disease (aGvHD) II-IV (p=0.052). (ucl.ac.uk)
  • Significant strides have been made in the survival rates of pediatric patients with grade 3 steroid-refractory acute graft-versus-host disease (aGvHD), although patients with the most severe cases (grade 4) of disease still have no or fewer benefits when it comes to long-term outcomes, according to new study findings. (ajmc.com)
  • This new approach to delivering immunosuppressant therapy suggests that local delivery of the drug to the grafted tissue has benefits in reducing toxicity, as well as markedly improving therapeutic outcomes, and may lead to a paradigm shift in clinical immunosuppressive therapy in transplant surgery,' said Jeff Karp of the Division of Biomedical Engineering at Brigham and Women's Hospital in Boston in a statement. (fiercepharma.com)
  • NK cells are the first lymphocytes that return to normal concentrations post-transplant ( 15 ), and separate studies report improved clinical outcomes of both high graft doses ( 16 , 17 ) and robust immune reconstitution ( 14 , 18 ) of NK cells. (frontiersin.org)
  • Survival differences between PD and hemodialysis (HD) have been widely debated, with differences in outcomes influenced by variations in the cohorts, patients, and follow-up time. (asnjournals.org)
  • Again, studies have offered differing results when comparing survival outcomes of DAGL with transplant-naive patients on dialysis, depending on the specific cohorts studied and the duration of follow-up ( 6 , 7 ). (asnjournals.org)
  • In the majority of the studies, patients who commenced PD after graft loss experienced outcomes comparable to those with failed native kidneys ( 8 , 9 ). (asnjournals.org)
  • Using California CABG Outcomes Reporting Program data, we classified all isolated CABG cases in 2003-2004 as having "probable survival enhancing indications (SEIs)", "possible SEIs" or "non-SEIs. (biomedcentral.com)
  • Nasdaq:MESO) today announced key Day 100 survival outcomes of its Phase 3 trial for remestemcel-L, an allogeneic mesenchymal stem cell product candidate, in children with steroid refractory acute Graft Versus Host Disease (aGVHD). (scienceinpublic.com.au)
  • Priori clinical outcomes were overall graft failure, death-censored graft failure and all-cause mortality. (biomedcentral.com)
  • HLA-A mismatching has minor but insignificant impact on graft survival outcomes. (biomedcentral.com)
  • Complete response, tumor immunity (GvL) and survival were considered as outcomes. (ki.se)
  • Therefore, induction therapy is widely used in KT to improve both short- and long-term graft outcomes. (sciepub.com)
  • The primary outcomes were graft and patient survival over a mean 3.4 years. (elsevier.com)
  • Since BC are diagnosed more frequently in HCV patients and only affect early graft loss, it is likely that recurrent HCV rather than BC accounts for the majority of adverse graft outcomes. (elsevier.com)
  • A ⩾50% reduction of the dominant donor-specific antibody (IgG-DSA) mean fluorescence intensity (MFI) has been associated with improved kidney allograft survival, and C1q-fixing DSA activity is associated with poor outcomes in patients with AMR. (elsevier.com)
  • Conclusions A rapid reduction of DSA concentration below the threshold required for complement activation is associated with better graft survival, and C1q-DSA is a better predictor of outcomes than IgG-DSA MFI reduction. (elsevier.com)
  • The National Surgical Quality Program (NSQIP) Transplant was designed by transplant surgeons from the ground up to track posttransplant outcomes beyond basic recipient and graft survival. (elsevier.com)
  • 95% CI 1.09-1.80), but this result was not explained by any combination of patient age with donor age, delayed graft function or immunosuppression. (oup.com)
  • For instance, a 40-year-old non-diabetic woman with primary biliary cirrhosis and a MELD score of 30 would be expected to have a much better post-transplant survival than a 65-year-old diabetic man with hepatitis C and a MELD score of 30, even though both have a similar mortality without transplant, since they have the same MELD score" he wrote. (medpagetoday.com)
  • In chronic Graft vs. Host Disease (GVHD), the differences between the donor bone marrow cells and the recipient's body often cause these immune cells to recognize the recipient's body tissues as foreign and the newly transplanted cells attack the transplant recipient's body. (eurekalert.org)
  • Explain to interested patients that there are several methods for predicting survival after a liver transplant, and that a predictive index of additional medical problems designed specifically for these patients appeared useful. (medpagetoday.com)
  • ANN ARBOR, Mich., Nov. 7 -- A simplified index to help predict five-year survival after a liver transplant isolated five comorbidities germane to these patients instead of the nine specified in an older version. (medpagetoday.com)
  • The researchers said that the modified comorbidity index predicted liver transplant survival as well or better than other available models that typically use recipient characteristics such as age, race, BMI, and etiology of liver disease. (medpagetoday.com)
  • Until now, "we have considered comorbidities in an informal way when deciding whether to put patients on the list for transplant, but nobody has ever quantified the impact of comorbidities on post-transplant survival," Dr. Volk said. (medpagetoday.com)
  • The addition of comorbidities to multivariable models may be useful in developing new allocation algorithms that incorporate the likelihood of post-transplant survival," the researchers concluded. (medpagetoday.com)
  • The standard Charlton index has been used in other areas, such as stem cell or kidney transplants, as relevant predictors of survival, but not among liver transplant patients where severity of illness has been the main criterion, Dr. Volk said. (medpagetoday.com)
  • Proportional hazards analysis determined the independent effect of each variable on post-transplant survival, and was then used to recalibrate the Charlson Comorbidity Index for use in the liver transplant population. (medpagetoday.com)
  • When the individual components of the index were analyzed, five variables turned out to be independent predictors of post-transplant survival. (medpagetoday.com)
  • The updated index improved the likelihood ratio chi-squared value from 15 to 24 for predicting post-transplant survival at five years. (medpagetoday.com)
  • The retrospective analysis examined trends in overall survival (OS), relapse incidence (RI), and transplant-related mortality (TRM) over nearly 3 decades, stratifying 90 pediatric patients from 3 time periods: 1989-1998, 1999-2007, and 2008-2017. (ajmc.com)
  • Researchers successfully delivered the immunosuppressant tacrolimus in a self-assembled hydrogel, enabling localized therapy in patients receiving a tissue graft transplant of the leg, hand or face. (fiercepharma.com)
  • 2004). Impact of body mass index on graft failure and overall survival following liver transplant. (rti.org)
  • METHODS: Renal hemodynamic and function studies using isotopic methods were prospectively performed in 493 renal transplant patients at 3 months posttransplantation to determine the impact of the different BP components on allograft survival using a proportional hazard model. (biomedsearch.com)
  • We now report that the magnitude of the Kw and Rw incompatibility is significantly associated not only with sustained "adaptive" hyperfiltration and early proteinuria but also with an increased risk for hypertension requiring more medication, a higher incidence of segmental or global glomerulosclerosis, and a significantly poorer long-term transplant survival. (asnjournals.org)
  • Actuarial survival analysis by type of transplant. (zanran.com)
  • A recent comparison of HD patients on the transplant waiting list found no difference in survival compared with patients on PD, suggesting that the previous studies had some residual confounding ( 5 ). (asnjournals.org)
  • The DAGL population has unique risk-modifying variables, including an increased risk for infection as a result of the effects of long-term immunosuppression, presence of a failed allograft as a source of chronic inflammation, and less exposure to predialysis care, and little is known regarding the impact of transplant residual renal function (RRF) on the survival in DAGL patients, making this an important question to address. (asnjournals.org)
  • Why, then, are these results different from the early PD survival benefit seen in transplant-naive patients who initiate dialysis? (asnjournals.org)
  • Between 1999 and 2012, 2,905 patients with acute myeloid leukemia (56%), acute lymphoblastic leukemia (30%) or myelodysplastic syndromes (14%) received a sibling (24%) or unrelated donor (76%) blood (66%) or marrow (34%) transplant and developed grade II-IV acute graft-versus-host disease (n=497 for 1999-2001, n=962 for 2002-2005, n=1,446 for 2006-2010). (jefferson.edu)
  • Graft survival refers to the success of the kidney in the kidney-pancreas transplant. (nm.org)
  • Using the large database of the Collaborative Transplant Study (CTS), this study is an evaluation of graft survival according to donor and recipient gender for renal (n = 124,911), cardiac (n = 25,432), and hepatic (n = 16,410) transplants. (semanticscholar.org)
  • However, in 2016 United States Renal Data System (USRDS) Annual Data Report, the long-term survival benefit remained unsatisfactory, with ten-year graft survival probabilities of 46.9% for deceased donor transplant [ 3 ]. (biomedcentral.com)
  • Within the positive B-FCXM group, no differences were found in pre-transplant anti-HLA class I or II alloimmunization as well as retransplantation frequency between the patients who lost their graft and the patients who did not. (oup.com)
  • In patients with type 1 diabetes and end-stage renal disease, a combined pancreas/kidney transplant was associated with significantly better 15-year survival than a single kidney graft alone. (portalediabete.org)
  • Patients who received the simultaneous transplant were younger than the living or deceased single graft groups (41 years vs. 45 and 55 years, respectively). (portalediabete.org)
  • In the first one, which controlled for recipient age, time on dialysis, and the transplant era, patients who got the dual graft were significantly more likely to survive to 15 years than were those who got the single live donor kidney (hazard ratio, 0.70). (portalediabete.org)
  • The article presents modifiable and non-modifiable factors (both on the recipient and the donor) determining the long-term survival of the renal transplant. (zdrav.by)
  • More importantly, NSQIP Transplant provides a powerful platform to improve care beyond basic patient and graft survival. (elsevier.com)
  • The chronic form of graft-versus-host-disease (cGvHD) normally begins 90 to 600 days post-transplant. (wikipedia.org)
  • Chapel Hill, NC - Leukemia and lymphoma patients who receive life-saving stem cell or bone marrow transplants often experience chronic side effects that significantly decrease quality of life, can last a lifetime, and ultimately affect their long-term survival. (eurekalert.org)
  • CONCLUSION: BMI did not significantly affect rates of graft failure. (rti.org)
  • Significantly, long-term graft survival was associated with alloreactive T cell anergy. (jimmunol.org)
  • The graft survival period was significantly prolonged (39.7 +/- 6.3 days) when them two treatments were combined. (biomedsearch.com)
  • Early immune reconstitution above median values of NK cells was significantly associated with improved relapse-free survival (HR 2.84 [95% CI 1.29-6.28], p = 0.01, and HR 4.19 [95% CI 1.68-10.4], p = 0.002, for day 28 and 56, respectively). (frontiersin.org)
  • 0.0005) correlated significantly with survival. (springer.com)
  • If a hospital has a significantly higher percentage of graft survival, it may indicate that it provides a higher level of patient care. (nm.org)
  • Walnut plants treated with Humisol at the total annual rate of 0.75 ml/plant had a significantly higher survival rate in the first year, greater height and diameter in both years, and a higher percentage of first-class plants at the end of the second year, as compared to untreated control plants. (agriculturejournals.cz)
  • Recipient survival at 48 months was not significantly different in the two groups. (oup.com)
  • However, graft survival at 12 and 48 months was significantly poorer in the positive B-FCXM than in negative B-FCXM (68% vs 90% at 12 months: P = 0.007, and 57% vs 79% at 48 months: P = 0.02). (oup.com)
  • One-year and overall patient and graft survival were significantly lower in patients with HCV, but BC impacted only 1-year graft survival. (elsevier.com)
  • This measure tracks the percentage of kidney graft survival out of all kidney-pancreas transplants performed at the hospital. (nm.org)
  • Methods and Results -Cardiomyocytes from fetal, neonatal, or adult inbred rats were grafted into normal myocardium, acutely cryoinjured myocardium, or granulation tissue (6 days after injury). (ahajournals.org)
  • RESEARCH DESIGN AND METHODS- Effects of MK0431 on islet graft survival in diabetic NOD mice were determined with metabolic studies and micropositron emission tomography imaging, and its underlying molecular mechanisms were assessed. (diabetesjournals.org)
  • Methods and Results We compared the 12-year survival outcome in a set of propensity-matched CABG patients who received either the RA or the saphenous vein as a secondary conduit. (ahajournals.org)
  • Graft survival rate , expressed as the percentage of sprouted grafts or buds, was evaluated 60 days after grafting for the three grafting methods. (thefreedictionary.com)
  • In the present study, the role of CD3 + T cells in grafts and impact on hematopoietic and immune recovery, cytomegalovirus (CMV) reactivation, GVHD, relapse, progress free survival and overall survival (OS) were evaluated and analyzed. (unboundmedicine.com)
  • In conclusion, high levels of CD3 + T cells in the grafts were associated with delayed lymphocyte recovery and an increased risk of acute GVHD and decreased overall survival. (unboundmedicine.com)
  • 3 However, the T-cell-mediated alloimmune response also leads to the occurrence of graft-versus-host disease (GvHD), which negatively influences outcome after allogeneic SCT. (haematologica.org)
  • GvHD after allogeneic SCT can be reduced by T-cell depletion of the stem cell graft, but this has been associated with an increased incidence of relapses. (haematologica.org)
  • Granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cells (G-PBSC) has largely replaced unstimulated bone marrow (un-BM) for allografting because of accelerated engraftment, but with a higher morbidity and mortality of graft-versus-host-disease (GVHD). (biomedcentral.com)
  • The primary study endpoint was GVHD-free/relapse-free survival (GRFS). (biomedcentral.com)
  • G-BM grafts lead a better GRFS and less GVHD associated with a higher MDSCs content compared with G-PBSC grafts. (biomedcentral.com)
  • The present thesis describes the effect and timing of photochemotherapy in relation to the onset and severity of cutaneous graft-versus-host (GvHD) in relation to the survival and cure of patients. (ki.se)
  • To improve the long-term disease free survival, we have to redirect the adoptive immunity from GvHD towards graft-versus-leukemia (GvL). (ki.se)
  • However, the effects of graft-versus-host disease (GVHD) with this platform are undefined. (elsevier.com)
  • Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. (wikipedia.org)
  • AMR cases in AB0-compatible, cross-match negative liver transplants with presence of anti-HLA antibodies have been described with graft function improvement after therapeutic depletion of anti-HLA antibodies titer [ 5 , 6 ]. (hindawi.com)
  • For patients who received kidney transplants in these eras, the 5-year graft survival rates increased with each successive era: 76.6%, 79.7%, 83.1%, and 85.4%, respectively. (renalandurologynews.com)
  • As the number of renal transplants increase and patient survival improves, we will see more patients on dialysis after graft loss (DAGL), and DAGL is now in the top five causes of dialysis initiation. (asnjournals.org)
  • Age of renal transplants has been related to death, alloimmune response and graft outcome. (oup.com)
  • This study aimed to assess the effect of SSD on long-term kidney allograft outcome and to compare the immunization status of grafted patients presenting with SSD following ATG induction treatment. (jci.org)
  • Early high pulse pressure is associated with graft dysfunction and predicts poor kidney allograft survival. (biomedsearch.com)
  • Because kidney allograft survival is closely related to BP levels, we investigated the impact of early high PP, systolic, diastolic, and mean arterial BP on kidney allograft survival. (biomedsearch.com)
  • Moreover, PP emerged as the strongest BP component influencing overall and death-censored kidney allograft survival. (biomedsearch.com)
  • MR1 administration was effective in prolonging allograft survival, but did not provide permanent protection from diabetes recurrence. (diabetesjournals.org)
  • Although immunomodulatory therapies targeting host T cells have improved short-term survival rates, rates of chronic allograft loss remain high. (jci.org)
  • We aimed to investigate if C1q-DSA can be used as a reliable predictor of response to therapy and allograft survival in patients with biopsy-proven AMR. (elsevier.com)
  • The new procedure of total grafting of arteries will reduce the risk and is expected to increase the rate of survival of the patient as well. (medindia.net)
  • Vascularized composite allotransplantation is the current paradigm to ensure graft survival, but involves chronic immunosuppression and systemic rather than localized delivery, subjecting the patient to side effects. (fiercepharma.com)
  • No differences were found in patient survival. (scielo.br)
  • Two-year actuarial patient and graft survival. (zanran.com)
  • Period 1990-2004: 2a) of the patient, 2b) of the graft, and 2c) of the graft with censored deaths. (zanran.com)
  • A Kt/V of 1.2 may be enough for some but not for others ( 1 ), hemoglobin targets may not be appropriate if the patient is slow to respond and requires a high dose of erythropoietin ( 2 ), and in fact peritoneal dialysis (PD) may offer a survival advantage for some and not for others as an initial modality choice ( 3 ). (asnjournals.org)
  • Between 1 and 3 years after surgery, Patient 3 showed only minor changes of parkinsonian symptoms on the side contralateral to the graft, whereas there was a worsening on the ipsilateral side. (lu.se)
  • Inflammatory markers like CRP and procalcitonin had no significant effect on one-year patient or graft survival after OLT (p=0.3 or p=0.8 respectively). (omicsonline.org)
  • 20.000/μl within the first four days after OLT was associated with a higher patient and graft mortality. (omicsonline.org)
  • 20.000/μl early after OLT is a cheap prognostic marker for patient and graft survival, while perioperative procalcitonin and CRP levels have no influence. (omicsonline.org)
  • Since more patients are surviving the initial resuscitation phase even with very large areas of skin being burned away, wound care has become increasingly important to ensure continued patient survival and improvement. (iupui.edu)
  • The aims of the present study were to investigate whether pretransplant HRQOL is associated with post-RTX patient survival or graft function, and to assess whether improvement in HRQOL from dialysis to RTX is associated with patient survival. (biomedcentral.com)
  • During the last decades, short-term graft and patient survival have improved due to upgraded surgical procedures, more efficient immunosuppressive regimens and improved care for complications and comorbidities. (biomedcentral.com)
  • Results: The actuarial graft survival rate at 1 year and S years was 68% (95% CI, 47% to 82%) and 54% (CI, 25% to 77%), respectively, whereas the actuarial patient survival rate was 87% (CI, 69% to 96%) at 1 and 5 years. (edu.au)
  • One patient had secondary graft failure and five patients failed to engraft. (nature.com)
  • Furthermore, the patient and graft survival as well as the serum creatinine levels upon discharge and at 1, 3, 6, 12 and 36 months were also comparable. (sciepub.com)
  • Whether or not a recipient achieves the best-predicted eGFR after KTx may have important implications for immediate patient management, as well as for long-term graft survival. (elsevier.com)
  • Kaplan-Meier survival estimates were determined, and factors that might be associated with graft and patient survival were analyzed using Cox proportional hazards regression modeling. (ox.ac.uk)
  • After adjustment for the factors found to influence graft and patient survival, these differences were no longer apparent. (ox.ac.uk)
  • Conclusions -Grafted fetal and neonatal cardiomyocytes form new, mature myocardium with the capacity to couple with injured host myocardium. (ahajournals.org)
  • Conclusions- Patients subjected to CABG within 7 days after thrombolysis demonstrated increased long-term survival. (ahajournals.org)
  • CONCLUSIONS- Treatment with MK0431 therefore reduced the effect of autoimmunity on graft survival partially by decreasing the homing of CD4 + T-cells into pancreatic β-cells through a pathway involving cAMP/PKA/Rac1 activation. (diabetesjournals.org)
  • 25% had a low frequency in the material reviewed, likely reflecting our organ utilization practices, and did not have a demonstrable effect on graft outcome. (nih.gov)
  • Ten-year follow-up of graft survival and visual outcome after penetrating keratoplasty in Sweden. (nih.gov)
  • To determine factors influencing graft survival and visual outcome 10 years after penetrating keratoplasty. (nih.gov)
  • Multiple regression analyses (logistic and linear) were performed on graft survival and visual outcome (visual acuity and astigmatism). (nih.gov)
  • Graft survival and visual outcome at 10 years depended on indication and postoperative complications. (nih.gov)
  • However, if these factors did influence outcome, then one may expect the survival in the first 2 years to be different from that of the later years as a result of a decline in RRF or death of patients using catheters. (asnjournals.org)
  • Our analysis shows that donor ECD did not affect outcome following corneal graft within the preselected categories, irrespective of diagnosis and after allowing for any potential confounding factors. (bmj.com)
  • Arai S et al, Poor outcome in steroid refractory graft versus host disease with anti-thymocyte globulin treatment. (scienceinpublic.com.au)
  • While improvements in treatment and supportive care have occurred, it is unknown whether these advances have resulted in improved outcome specifically among those diagnosed with acute graft-versus-host disease. (jefferson.edu)
  • We examined outcome following diagnosis of grade II-IV acute graft-versus-host disease according to time period, and explored effects according to original graft-versus-host disease prophylaxis regimen and maximum overall grade of acute graft-versus-host disease. (jefferson.edu)
  • However, limited data are available regarding the long-term outcome of the radial artery (RA) as a secondary conduit over the established standard of the saphenous venous graft. (ahajournals.org)
  • 2 The use of the radial artery (RA) for coronary artery bypass graft surgery (CABG) was first introduced by Carpentier et al 3 in 1973 but was abandoned due to an initially unfavorable outcome. (ahajournals.org)
  • Primary outcome was graft loss. (ahajournals.org)
  • With limited numbers of peripheral blood stem cell grafts in pediatric patients (n=12), graft- versus -host disease-free, relapse-free survival did not differ between bone marrow and peripheral blood stem cell graft from any donor. (haematologica.org)
  • Berger M, Pessolano R, Carraro F, Saglio F, Vassallo E, Fagioli F. Steroid-refractory acute graft-versus-host disease graded III-IV in pediatric patients. (ajmc.com)
  • Rapamycin for refractory acute graft-versus-host disease. (biomedsearch.com)
  • Graft- versus -host disease-free, relapse-free survival was defined as the absence of grade III-IV acute graft- versus -host disease, chronic graft- versus -host disease (requiring systemic therapy or extensive stage), relapse and death. (haematologica.org)
  • While not all patients have a matched sibling donor, graft- versus -host disease-free, relapse-free survival may be improved by the preferential use of bone marrow for adults with malignant diseases. (haematologica.org)
  • Alternatively, novel graft- versus -host disease prophylaxis regimens are needed to substantially impact graft- versus -host disease-free, relapse-free survival with the use of peripheral blood stem cell. (haematologica.org)
  • Additional interferon-α was administered when no acute graft- versus -host-disease occurred within 3 weeks after donor-lymphocyte infusion. (haematologica.org)
  • Of these 44 patients, seven were not eligible for cytoreductive treatment because of poor performance status (n=3) or severe graft- versus -host-disease (n=4) at the time of relapse. (haematologica.org)
  • The impact of acute graft- versus -host-disease on survival was calculated with a Cox-regression model including onset of acute graft- versus -host-disease as a time-dependent variable. (haematologica.org)
  • Development of grade 1-3, but not grade 4, acute graft- versus -host-disease was associated with superior survival as compared to absence of graft- versus -host-disease (hazard ratio 0.22, P =0.03). (haematologica.org)
  • A phase 2/3 multicenter randomized clinical trial of ABX-CBL versus ATG as secondary therapy for steroid-resistant acute graft-versus-host disease. (scienceinpublic.com.au)
  • Infliximab for managing steroid-refractory acute graft-versus-host disease. (scienceinpublic.com.au)
  • Acute graft versus host disease was diagnosed in 42% of patients, and 47% required vasopressors. (springer.com)
  • Improved survival after acute graft-versus-host disease diagnosis in t" by Hanna J. Khoury, Tao Wang et al. (jefferson.edu)
  • Improved survival after acute graft-versus-host disease diagnosis in the modern era. (jefferson.edu)
  • I. Photochemotherapy of cutaneous graft-versus-host disease may reduce concomitant visceral disease. (ki.se)
  • Severity of graft-versus-host disease confined to the skin predicts pulmonary mortality after irradiation, photochemotherapy possibly alleviates lung injury. (ki.se)
  • Graft-versus-host disease prophylaxis was tacrolimus and methotrexate. (nature.com)
  • 4-year actuarial survival is 33 versus 0% for patients transplanted in remission versus in relapse. (nature.com)
  • In the clinical setting, graft-versus-host-disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
  • In the classical sense, acute graft-versus-host-disease is characterized by selective damage to the liver, skin (rash), mucosa, and the gastrointestinal tract. (wikipedia.org)
  • Newer research indicates that other graft-versus-host-disease target organs include the immune system (the hematopoietic system, e.g., the bone marrow and the thymus) itself, and the lungs in the form of immune-mediated pneumonitis. (wikipedia.org)
  • Chronic graft-versus-host-disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands. (wikipedia.org)
  • He used proportional-hazards regression to identify the donor and recipient characteristics that best predicted survival, and incorporated those characteristics into a multivariate model. (medpagetoday.com)
  • The models make explicit in a multivariate analysis which donor and recipient characteristics have the greatest impact on survival. (medpagetoday.com)
  • Although all the variables included in the model are important, donor age, cold ischemia time, recipient MELD score, and cause of liver disease have the greatest impact on survival. (medpagetoday.com)
  • Long-term function of kidney allografts depends on multiple variables, one of which may be the compatibility in size between the graft and the recipient. (asnjournals.org)
  • Even if a suitable graft is found, poor retention due to infection, hematoma, and low vascularity at the recipient site are other drawbacks associated with the use of skin grafts as a primary treatment for severe burn wounds. (iupui.edu)
  • HLA mismatching was still a critical prognostic factor that affects graft and recipient survival. (biomedcentral.com)
  • There was no difference between the young and old recipient age groups for graft survival rate , after a mean follow up period of 120 months (p=0. (thefreedictionary.com)
  • sup][7] The aim of this study was to provide an extensive study according to different recipient sites and fat graft survival rate (SR). (thefreedictionary.com)
  • The aim of this cohort study was to calculate the renal function recovery (RFR) based on recipient and donor eGFR and to evaluate the association between RFR and long-term death-censored graft failure (DCGF). (elsevier.com)
  • White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
  • While currently a common treatment for third degree burn wounds, skin grafts have several drawbacks. (iupui.edu)
  • Full thickness skin grafts from the groin: donor site morbidity and graft survival rate from 50 cases. (thefreedictionary.com)
  • According to the study's abstract in the Aug. 13 edition of Science Translational Medicine , median graft survival was more than 100 days in rats treated with the tacrolimus delivered via hydrogel, compared to 33.5 days in rats treated with tacrolimus only and 11 days in rats that were either untreated or treated with hydrogel only. (fiercepharma.com)
  • abstract = "The purpose of this study was to analyze the effect of gender on deployment, early morbidity, and survival after endovascular aortic aneurysm repair (EVAR) using the Zenith Endovascular Graft. (elsevier.com)
  • The stem cell graft not only contains stem cells that establish donor derived hematopoiesis, but also mature immune cells responsible for early elimination of residual tumor cells through the graft-vs.-tumor (GVT) effect ( 4 , 5 ). (frontiersin.org)
  • Increasing degrees of glomerulosclerosis (GS) were associated with earlier graft failure on univariate (P=0.03) but not multivariate analysis (P=0.36). (nih.gov)
  • Interestingly, WBC early after OLT was a prognostic marker for patients (p=0.019) and graft survival (p=0.03). (omicsonline.org)
  • Patients with graft function have a high long-term survival. (nih.gov)
  • However, there is little information regarding long-term survival in this setting. (ahajournals.org)
  • The purpose of the present study was to compare the long-term survival of patients subjected to CABG after thrombolysis to those without thrombolysis. (ahajournals.org)
  • 6-8 However, there is limited published data on long-term survival rates in this subgroup of patients. (ahajournals.org)
  • The purpose of the present study was to compare the long-term survival of patients who were treated with thrombolysis within 7 days before CABG with CABG patients without prior thrombolysis. (ahajournals.org)
  • In this study, we address mechanisms through which inhibition of the mammalian target of rapamycin (Rapa) synergizes with alloantigen-specific Treg (AAsTreg) to permit long-term, donor-specific heart graft survival in immunocompetent hosts. (jimmunol.org)
  • These findings delineate combination of transient mammalian target of Rapa inhibition with appropriate AAsTreg selection as an effective approach to promote long-term organ graft survival. (jimmunol.org)
  • However, the impact of introduction of generic immunosuppressants on long term graft survival was never systematically evaluated in well controlled clinical studies. (nih.gov)
  • Islet revascularization is a subsequent critical step for the long-term function of the transplanted graft, which may partially be impeded by the IBMIR.In this thesis, we have explored novel strategies for circumventing the effects of the IBMIR and facilitating islet revascularization.Systemic inhibitors of the IBMIR are typically associated with an increased risk of bleeding. (avhandlingar.se)
  • We hypothesized that initial disease control by effective cytoreduction, followed by rapid induction of a profound allo-immune response by donor-lymphocyte infusion during the neutropenic phase, is essential for long-term survival. (haematologica.org)
  • Conclusion The RA as a secondary conduit provided superior long-term survival after CABG, especially in diabetic patients, women, and the elderly. (ahajournals.org)
  • Background: Chronic obstructive pulmonary disease (COPD) is a known predictor of decreased long-term survival after coronary artery bypass grafting (CABG). (uncg.edu)
  • Long-term survival was compared in patients with and without COPD and stratified by race. (uncg.edu)
  • However, long-term term attrition rates for renal grafts have only shown small improvements, and survival in RTX patients is reduced compared to the general population [ 4 - 6 ]. (biomedcentral.com)
  • CONCLUSION: Our results suggest that a pretransplant positive B-FCXM is associated with an impaired long-term graft survival in renal allotransplantation. (oup.com)
  • Prognostic value for long-term graft survival of estimated glo. (mysciencework.com)
  • We aimed to assess the prognostic value for long-term graft survival of the early (3 months) quantification of eGFR and proteinuria following KT. (mysciencework.com)
  • The appearance of moderate to severe cases of cGVHD adversely influences long-term survival. (wikipedia.org)
  • Prospective clinical trials should address whether it is directly caused by lipotoxicity and if strategies focusing lowering serum lipids may prolong islet graft survival. (diabetesjournals.org)
  • Minimization of immunosuppression and donor-specific tolerance to MHC-mismatched organ grafts are important clinical goals. (jimmunol.org)
  • Three years after grafting the patients still exhibited increased fluorodopa uptake in the grafted putamen and significant clinical improvements, evidenced by a reduction of the severity of symptoms and of the time spent in the "off" phase, and by a prolongation of the effect of a single dose of L-dopa. (lu.se)
  • Our results suggest that MSCs are uniquely positioned for use in future clinical studies owing to their ability to protect DCD liver grafts, particularly in patients for whom DCD organs are not an option according to current criteria. (springer.com)
  • Based on interactions with the FDA, Mesoblast believes that successful results from the completed Phase 3 trial, together with Day 180 safety, survival and quality of life parameters in these patients, may provide sufficient clinical evidence to file for accelerated approval of remestemcel-L in the United States, where there are currently no approved products for steroid-refractory aGVHD. (scienceinpublic.com.au)
  • Background The clinical benefits of the left internal thoracic artery-to-left anterior descending coronary artery graft are well established in coronary artery bypass graft surgery (CABG). (ahajournals.org)
  • These data suggest that UV-B pretreatment of donor corneal endothelium prolongs graft survival but that toxic side effects must be carefully controlled. (harvard.edu)
  • The effect of donor age on corneal graft survival]. (semanticscholar.org)
  • The effect of donor age on corneal graft survival was evaluated. (semanticscholar.org)
  • This study evaluates the predictive value of serum triglyceride levels on mortality in post-coronary artery bypass graft (CABG) diabetic patients with subsequent analysis by sex. (diabetesjournals.org)
  • Background- Coronary artery bypass grafting (CABG) is frequently used after thrombolytic therapy. (ahajournals.org)
  • Studies in the 1980s demonstrated that coronary artery bypass grafting (CABG) performed after acute myocardial infarction treated with thrombolysis was safe, and the risk for early mortality did not appear to be different than that of elective operation performed at a time remote from an acute myocardial infarction. (ahajournals.org)
  • Coronary artery bypass graft (CABG) surgery is performed because of anticipated survival benefit, improvement in quality of life, or both. (biomedcentral.com)
  • COPD was observed to be a statistically significant predictor of decreased survival independent of race following CABG (no COPD: HR? (uncg.edu)
  • Conclusion: Contrary to the expected increased risk of mortality among black COPD patients in the general population, a similar survival disadvantage was not observed in our CABG population. (uncg.edu)
  • Treatment with donor-specific transfusion+rapamycin+anti-OX40L increased the mean graft survival time from 5.2 days (control group) to 42.5 days (p (sigmaaldrich.com)
  • Subjects with baseline fasting plasma triglycerides and VLDL-cholesterol above median had shorter islet graft survival (triglycerides: 39.7±6.1 vs. 61.3±6.6 months, P=0.029 and VLDL: 41.5±5.7 vs. 62.8±7.3 months, P=0.032). (diabetesjournals.org)
  • Higher baseline triglycerides are associated with earlier decline in islet graft function. (diabetesjournals.org)
  • Here we report the beneficial effect of the chronic administration of a hamster anti-murine CD154 mAb, MR1, in prolonging islet graft survival in NOD mice. (diabetesjournals.org)
  • The current study was initiated to define the effects of the DPP-IV inhibitor sitagliptin (MK0431) on transplanted islet survival in nonobese diabetic (NOD) mice, an autoimmune type 1 diabetes model. (diabetesjournals.org)
  • In preclinical studies, the DPP-IV inhibitor isoleucine thiazolidide was shown to improve glucose tolerance in both streptozotocin (STZ)-induced ( 18 , 19 ) and BioBreeding (BB) ( 19 ) diabetic rats, associated with increased β-cell survival and possibly islet neogenesis ( 18 ). (diabetesjournals.org)
  • Additionally, we recently showed that the DPP-IV inhibitor MK0431 prolonged islet graft survival in STZ-induced diabetic mice ( 20 ). (diabetesjournals.org)
  • In the current study, we show that MK0431 pretreatment resulted in the prolongation of islet graft survival in an autoimmune type 1 diabetes model, the nonobese diabetic (NOD) mouse, through a mechanism that includes modulation of CD4 + T-cell migration. (diabetesjournals.org)
  • Effect of incision width on graft survival and endothelial cell loss after Descemet stripping automated endothelial keratoplasty. (nih.gov)
  • To assess the effect of incision width (5.0 and 3.2 mm) on graft survival and endothelial cell loss 6 months and 1 year after Descemet stripping automated endothelial keratoplasty (DSAEK). (nih.gov)
  • This retrospective analysis assessed graft survival, complications, and endothelial cell loss, which was calculated from baseline donor and 6-month and 1-year postoperative central endothelial images evaluated by an independent specular microscopy reading center. (nih.gov)
  • We propose the delivery of adipose derived stem cells (ASC) in combination with endothelial progenitor cells (EC) via Integra Dermal Regenerative Template (DRT) to promote faster graft vascularization and thus faster healing of wounds. (iupui.edu)
  • Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice. (woodrufflab.org)
  • Survival after RTX was higher in patients who perceived good physical function (PF) in dialysis compared to patients with poorer PF ( p = 0.019). (biomedcentral.com)
  • No primary graft failures occurred in either group. (nih.gov)
  • 300 compared with ≥ 300 in the time to extubation, grade of primary graft dysfunction, pulmonary function at 6 and 12 months, and 12-month survival. (monash.edu)
  • More commonly, however, grafts were separated from the host myocardium by scar tissue. (ahajournals.org)
  • Optimal repair, however, may require reducing the isolation of the graft by the intervening scar tissue. (ahajournals.org)
  • 2) Can grafts survive equally well in normal myocardium, acutely necrotic tissue, and granulation (wound repair) tissue? (ahajournals.org)
  • Previous studies indicate that 80-95% of grafted dopamine neurons die following implantation of embryonic ventral mesencephalic tissue into the striatum. (lu.se)
  • Two patients with idiopathic Parkinson's disease (Patients 3 and 4 in our series) were followed up to 3 years after grafting of human embryonic dopamine-rich mesencephalic tissue unilaterally into the putamen. (lu.se)
  • The strength of pairing is that it is an indirect measure of "tissue quality" i.e. , characteristics of the transplanted tissue affect its function and survival, including its ability to withstand stress and repair injuries. (asnjournals.org)
  • In order to improve graft survival and to bypass side effects of nonspecific immunosuppressants, it is crucial to develop strategies that induce alloantigen-specific immune tolerance. (nature.com)
  • Low platelet (≤ 50,000/μl) and poor graft function are independent prognostic factors for impaired survival in critically ill stem cell transplanted patients. (springer.com)
  • Surgeons from Cedars-Sinai Medical Center, US, have found that patients who had blockages in multiple of coronary arteries have more life span when they undergo arterial grafts that will restore blood flow to all areas of the heart. (medindia.net)
  • Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysis. (diabetesjournals.org)
  • With the use of the left internal thoracic artery (LITA)-to-left anterior descending coronary artery (LAD) graft as an established standard for coronary artery bypass, 1 cardiothoracic surgeons have been searching for other durable vascular conduits. (ahajournals.org)
  • Groups were compared by Cox proportional hazard models and Kaplan-Meier survival plots. (ahajournals.org)
  • The 3-gene signature also stratified patients at high risk of graft failure as soon as 15 days after biopsy. (jci.org)
  • High M1 score increases the risk of graft failure. (jci.org)
  • Six-month graft survival and renal function were reduced in grafts for which the mate kidney displayed any criteria for functional impairment (dialysis dependency, low urine output [≤1 L] in the first 24 h posttransplant or day-7 serum creatinine ≥ 400 μmol/L), even for kidneys which themselves lacked those criteria. (asnjournals.org)
  • Actuarial survival of patients grafted within 2 years of diagnosis or later: the difference is highly significant (P=0.0004). (zanran.com)
  • than 2 years of diagnosis (n=37) had actuarial survival rates of 87%, 86%, and 55%, respectively. (zanran.com)
  • Actuarial survival curve of patients with bilateral internal thoracic artery and GEA grafts (solid line) and single internal thoracic artery and GEA grafts (dotted line) by the Kaplan-Meier method. (zanran.com)
  • Differences in actuarial graft survival according to donor gender have been reported for renal allografts and for cardiac and hepatic allografts, but for the latter in small series with limited biostatistical power. (semanticscholar.org)
  • Here, we assess the effects of a novel immunosuppressive strategy on graft survival and host immune response. (sigmaaldrich.com)
  • MSCs exert powerful immunosuppressive functions via paracrine effects and cell-cell contact-dependent interactions, and MSCs also inhibit the proliferation of activated lymphocytes, thereby providing survival signals to resting immune cells and subsequently stimulating the induction of regulatory immune cells [ 12 ]. (biomedcentral.com)
  • range 8 days to 94 months), no impact on short-term graft survival was observed. (asnjournals.org)
  • Donation after cardiac death (DCD) is an alternative approach that may expand the donor pool, but it faces challenges such as graft dysfunction, early graft loss, and cholangiopathy. (springer.com)
  • 25), and the impact of increasingly elevated BMI (25-40+) on graft failure rates and overall survival rates are assessed using proportional hazards regression. (rti.org)
  • Top line Day 100 results demonstrated 87% survival rate for Day 28 responders to remestemcel-L treatment (33/38), and an overall survival rate of 75% (41/55). (scienceinpublic.com.au)
  • Using a well-established mouse BMT model in which aGVHD is induced across a haploidentical mismatch, we show that the expression of heme oxygenase-1 (HO-1) can be induced by cobalt-protoporphyrin IX (CoPP) in aGVHD target organs such as liver and bowel and that the induction of HO-1 before BMT results in improved overall survival and reduced aGVHD. (uni-regensburg.de)
  • In landmark analyses at 100 days after HLA-matched BMT, 4-year overall survival (OS) and progression-free survival (PFS) were 57% (95% confidence interval [CI], .49 to .67) and 40% (95% CI, .31 to .51) in patients without grades II to IV aGVHD, and 68% (95% CI, .59 to .78) and 54% (95% CI, .44 to .65) in patients with grade II aGVHD. (elsevier.com)
  • To avoid misclassification bias, implants were excluded if bone grafts were only done at the same time of placement. (quintpub.com)
  • Bone grafts were taken from the anterior or posterior iliac crest and implants were placed between 3 and 6 months after the osteotomy. (ru.nl)
  • These results indicate that grafts of embryonic dopamine neurons can survive, grow, and exert functional effects up to at least 3 years after surgery in the parkinsonian brain, despite an ongoing disease process leading to degeneration of the intrinsic dopamine system. (lu.se)
  • Patel, Sanjay V. / Graft survival after penetrating keratoplasty . (elsevier.com)
  • Numerous studies have been carried out in recent years to identify novel strategies to alleviate DCD liver graft injury. (biomedcentral.com)