Graft survival. Medical search

The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.

The transference of a kidney from one human or animal to another.

An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

The transference of a part of or an entire liver from one human or animal to another.

A dead body, usually a human body.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.

Elements of limited time intervals, contributing to particular results or situations.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Non-cadaveric providers of organs for transplant to related or non-related recipients.

The transference of a pancreas from one human or animal to another.

Obstruction of flow in biological or prosthetic vascular grafts.

Partial or total replacement of the CORNEA from one human or animal to another.

The transference of a heart from one human or animal to another.

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

Partial or total replacement of all layers of a central portion of the cornea.

The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.

A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.

Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.

Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)

Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.

The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.

A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).

General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.

The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.

Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.

The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).

Continuance of life or existence especially under adverse conditions; includes methods and philosophy of survival.

An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)

Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.

An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.

A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.

Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.

The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. It may be induced passively by introducing graft-specific antibodies from previously immunized donors, which bind to the graft's surface antigens, masking them from recognition by T-cells; or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity.

Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.

Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)

Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.

A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.

Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.

Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.

A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.

The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)

Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.

Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.

Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.

Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.

Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.

The return of a sign, symptom, or disease after a remission.

The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.

Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.

Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.

The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.

Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.

New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

The degree to which BLOOD VESSELS are not blocked or obstructed.

The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).

Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.

A trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal.

Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.

Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

Antibodies produced by a single clone of cells.

Transference of fetal tissue between individuals of the same species or between individuals of different species.

The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.

Tissues, cells, or organs transplanted between genetically different individuals of the same species.

Polyester polymers formed from terephthalic acid or its esters and ethylene glycol. They can be formed into tapes, films or pulled into fibers that are pressed into meshes or woven into fabrics.

The vein which drains the foot and leg.

Therapy with two or more separate preparations given for a combined effect.

Prospective patient listings for appointments or treatments.

Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.

The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)

Transference of an organ between individuals of the same species or between individuals of different species.

The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.

Disease having a short and relatively severe course.

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.

Transplantation between animals of different species.

A surgical procedure or KERATOPLASTY involving selective stripping and replacement of diseased host DESCEMET MEMBRANE and CORNEAL ENDOTHELIUM with a suitable and healthy donor posterior lamella. The advantage to this procedure is that the normal corneal surface of the recipient is retained, thereby avoiding corneal surface incisions and sutures.

Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.

An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.

The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

The vessels carrying blood away from the capillary beds.

A short thick vein formed by union of the superior mesenteric vein and the splenic vein.

Single layer of large flattened cells covering the surface of the cornea.

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

Pathological processes of the KIDNEY or its component tissues.

An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.

A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.

Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.

Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or due to FUCHS' ENDOTHELIAL DYSTROPHY; ANGLE-CLOSURE GLAUCOMA; IRITIS; or aging.

Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.

The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)

A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.

Pathological processes of the LIVER.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.

Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.

A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.

The period following a surgical operation.

A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.

The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.

Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.

Diseases of the cornea.

INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.

Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.

The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.

A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.

The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.

The transference of either one or both of the lungs from one human or animal to another.

Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use.

A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).

The study of chance processes or the relative frequency characterizing a chance process.

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Application of pharmaceutically active agents on the tissues of the EYE.

Formation and development of a thrombus or blood clot in the blood vessel.

A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

Transplantation of an individual's own tissue from one site to another site.

The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

The shell-like structure projects like a little wing (pinna) from the side of the head. Ear auricles collect sound from the environment.

Excision of kidney.

An encapsulated lymphatic organ through which venous blood filters.

The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)

Surgical shunt allowing direct passage of blood from an artery to a vein. (From Dorland, 28th ed)

The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.

A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)

Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

The plan and delineation of prostheses in general or a specific prosthesis.

Transference of cells within an individual, between individuals of the same species, or between individuals of different species.

Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.

Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.

The main artery of the thigh, a continuation of the external iliac artery.

The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.

Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.

Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)

Derivatives of propylene glycol (1,2-propanediol). They are used as humectants and solvents in pharmaceutical preparations.

Tumors or cancer of the LUNG.

A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)

The formation of LYMPHATIC VESSELS.

The condition of an anatomical structure's being constricted beyond normal dimensions.

Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.

Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.

Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.

A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.

Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Tumors or cancer of the human BREAST.

A PREDNISOLONE derivative with similar anti-inflammatory action.

CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)

Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.

Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.

Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.

Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

Autografting with philadelphia chromosome-negative mobilized hematopoietic progenitor cells in chronic myelogenous leukemia. (1/5787)

Intensive chemotherapy given in early chronic phase of chronic myelogenous leukemia (CML) has resulted in high numbers of circulating Philadelphia (Ph) chromosome-negative hematopoietic progenitor cells (HPC). We have autografted 30 consecutive patients with CML in chronic phase with HPC collected in this way to facilitate restoration of Ph-negative hematopoiesis in bone marrow after high-dose therapy. Hematopoietic recovery to greater than 0.5 x10(9)/L neutrophils and to greater than 25 x 10(9)/L platelets occurred in all patients, a median of 13 (range, 9 to 32) days and 16 (range, 6 to 106) days postautograft, respectively. Regenerating marrow cells were Ph-negative in 16 (53%) patients and greater than 66% Ph-negative in 10 (33%) patients. Twenty-eight patients are alive 6 to 76 months (median, 24 months) after autografting. Three patients have developed blast crisis from which 2 have died. Eight patients are in complete cytogenetic remission at a median of 20 (range, 6 to 44) months with a median ratio BCR-ABL/ABL of 0.002 (range, <0.001 to 0.01). Eight patients are in major cytogenetic remission at a median of 22 (range, 6 to 48) months. No patient died as a consequence of the treatment. All patients had some degree of stomatitis that was severe in 15 (50%) patients. Gastrointestinal and hepatic toxicities were observed in about one fourth of patients. Thus, autografting with Ph-negative mobilized HPC can result in prolonged restoration of Ph-negative hematopoiesis for some patients with CML; moreover, most autograft recipients report normal or near normal activity levels, suggesting that this procedure need not to be associated either with prolonged convalescence or with chronic debility. (+info)

Organ-selective homing defines engraftment kinetics of murine hematopoietic stem cells and is compromised by Ex vivo expansion. (2/5787)

Hematopoietic reconstitution of ablated recipients requires that intravenously (IV) transplanted stem and progenitor cells "home" to organs that support their proliferation and differentiation. To examine the possible relationship between homing properties and subsequent engraftment potential, murine bone marrow (BM) cells were labeled with fluorescent PKH26 dye and injected into lethally irradiated hosts. PKH26(+) cells homing to marrow or spleen were then isolated by fluorescence-activated cell sorting and assayed for in vitro colony-forming cells (CFCs). Progenitors accumulated rapidly in the spleen, but declined to only 6% of input numbers after 24 hours. Although egress from this organ was accompanied by a simultaneous accumulation of CFCs in the BM (plateauing at 6% to 8% of input after 3 hours), spleen cells remained enriched in donor CFCs compared with marrow during this time. To determine whether this differential homing of clonogenic cells to the marrow and spleen influenced their contribution to short-term or long-term hematopoiesis in vivo, PKH26(+) cells were sorted from each organ 3 hours after transplantation and injected into lethally irradiated Ly-5 congenic mice. Cells that had homed initially to the spleen regenerated circulating leukocytes (20% of normal counts) approximately 2 weeks faster than cells that had homed to the marrow, or PKH26-labeled cells that had not been selected by a prior homing step. Both primary (17 weeks) and secondary (10 weeks) recipients of "spleen-homed" cells also contained approximately 50% higher numbers of CFCs per femur than recipients of "BM-homed" cells. To examine whether progenitor homing was altered upon ex vivo expansion, highly enriched Sca-1(+)c-kit+Lin- cells were cultured for 9 days in serum-free medium containing interleukin (IL)-6, IL-11, granulocyte colony-stimulating factor, stem cell factor, flk-2/flt3 ligand, and thrombopoietin. Expanded cells were then stained with PKH26 and assayed as above. Strikingly, CFCs generated in vitro exhibited a 10-fold reduction in homing capacity compared with fresh progenitors. These studies demonstrate that clonogenic cells with differential homing properties contribute variably to early and late hematopoiesis in vivo. The dramatic decline in the homing capacity of progenitors generated in vitro underscores critical qualitative changes that may compromise their biologic function and potential clinical utility, despite their efficient numerical expansion. (+info)

A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/mycophenolate mofetil in renal transplant recipients. (3/5787)

BACKGROUND: Between September 20, 1995 and September 20, 1997, 208 adult patients undergoing renal transplantation were randomized to receive tacrolimus/prednisone (n=106) or tacrolimus/prednisone/mycophenolate mofetil (n=102), with the goal of reducing the incidence of rejection. METHODS: The mean recipient age was 50.7+/-13.7 years. Sixty-three (30.3%) patients were 60 years of age or older at the time of transplantation. The mean donor age was 34.5+/-21.7 years. The mean cold ischemia time was 30.5+/-9.2 hr. The mean follow-up is 15+/-7 months. RESULTS: The overall 1-year actuarial patient survival was 94%; the overall 1-year actuarial graft survival was 87%. When the patient and graft survival data were stratified to recipients under the age of 60 who did not have delayed graft function, the overall 1-year actuarial patient survival was 97%, and the corresponding 1-year actuarial graft survival was 93%. There were no differences between the two groups. The overall incidence of rejection was 36%; in the double-therapy group, it was 44%, whereas in the triple therapy group, it was 27% (P=0.014). The mean serum creatinine was 1.6+/-0.8 mg/dl. A total of 36% of the successfully transplanted patients were taken off prednisone; 32% of the patients were taken off antihypertensive medications. The incidence of delayed graft function was 21%, the incidence of cytomegalovirus was 12.5%, and the initial and final incidences of posttransplant insulin-dependent diabetes mellitus were 7.0% and 2.9%; again, there was no difference between the two groups. CONCLUSIONS: This trial suggests that the combination of tacrolimus, steroids, and mycophenolate mofetil is associated with excellent patient and graft survival and a lower incidence of rejection than the combination of tacrolimus and steroids. (+info)

Bone marrow transplantation in pediatric patients with therapy-related myelodysplasia and leukemia. (4/5787)

Eleven children underwent BMT for therapy-related MDS or leukemia, four from HLA-identical siblings and seven from unrelated donors. Ten of the 11 were conditioned with busulfan and cyclophosphamide as the majority had received prior irradiation to the chest and/or abdomen. All patients engrafted. Regimen-related toxicity was more common when compared to historical controls. Eight patients developed acute GVHD and four of eight who survived 100 days post transplant developed extensive chronic GVHD. Non-relapse related mortality occurred in three patients. Five patients developed recurrent malignancy: one died from recurrence of osteosarcoma, three died of recurrent leukemia or MDS and another developed two subsequent malignancies (duodenal carcinoma and anaplastic astrocytoma). Three survive disease-free at 14+, 22+ and 43+ months for a 2 year actuarial cancer-free survival of 24% (95% confidence interval = 5-53%). Although allogeneic BMT can be curative, regimen-related toxicity is frequent and recurrent malignancy remains the major obstacle. (+info)

Infrainguinal revascularisation in the era of vein-graft surveillance--do clinical factors influence long-term outcome? (5/5787)

OBJECTIVES: To investigate the variables affecting the long-term outcome of infrainguinal vein bypass grafts that have undergone postoperative surveillance. DESIGN: A retrospective analysis. PATIENTS AND METHODS: Details of 299 consecutive infrainguinal vein grafts performed in 275 patients from a single university hospital were collected and analysed. All grafts underwent postoperative duplex surveillance. Factors affecting patency, limb salvage and survival rates were examined. These factors were gender, diabetes, hypertension, aspirin, warfarin, ischaemic heart disease, run-off, graft type, early thrombectomy, level of anastomoses and indication for surgery. RESULTS: The 6-year primary, primary assisted and secondary patency rates were 23, 47, and 57%, respectively. Six-year limb salvage and patient survival were 68 and 45%, respectively. Primary patency was adversely influenced by the use of composite vein grafts. Early thrombectomy was the only factor that significantly influenced secondary patency. Limb salvage was worse in diabetic limbs, limbs with poor run-off and in grafts that required early thrombectomy. Postoperative survival was better in males, claudicants and in patients who took aspirin. CONCLUSIONS: Although co-morbid factors did not influence graft patency rates, diabetes did adversely effect limb salvage. This study, like others before it, confirms that aspirin significantly reduces long-term mortality in patients undergoing infrainguinal revascularisation. (+info)

A glial cell line-derived neurotrophic factor-secreting clone of the Schwann cell line SCTM41 enhances survival and fiber outgrowth from embryonic nigral neurons grafted to the striatum and to the lesioned substantia nigra. (6/5787)

We have developed a novel Schwann cell line, SCTM41, derived from postnatal sciatic nerve cultures and have stably transfected a clone with a rat glial cell line-derived neurotrophic factor (GDNF) construct. Coculture with this GDNF-secreting clone enhances in vitro survival and fiber growth of embryonic dopaminergic neurons. In the rat unilateral 6-OHDA lesion model of Parkinson's disease, we have therefore made cografts of these cells with embryonic day 14 ventral mesencephalic grafts and assayed for effects on dopaminergic cell survival and process outgrowth. We show that cografts of GDNF-secreting Schwann cell lines improve the survival of intrastriatal embryonic dopaminergic neuronal grafts and improve neurite outgrowth into the host neuropil but have no additional effect on amphetamine-induced rotation. We next looked to see whether bridge grafts of GDNF-secreting SCTM41 cells would promote the growth of axons to their striatal targets from dopaminergic neurons implanted orthotopically into the 6-OHDA-lesioned substantia nigra. We show that such bridge grafts increase the survival of implanted embryonic dopaminergic neurons and promote the growth of axons through the grafts to the striatum. (+info)

Reduced kidney transplant rejection rate and pharmacoeconomic advantage of mycophenolate mofetil. (7/5787)

BACKGROUND: Several multinational controlled clinical trials have shown that triple therapy immunosuppressive regimens which include mycophenolate mofetil (MMF), cyclosporin A (CSA) and steroids (S) are superior compared with conventional regimens which include azathioprine (AZA), CSA and S, mainly because MMF reduces the rate of acute rejection episodes in the first 6 months after kidney transplantation. Post-marketing studies are useful to evaluate the general applicability and costs of MMF-based immunosuppressive regimens. METHODS: Based on the excellent results of the published controlled clinical trials, we have changed the standard triple therapy immunosuppressive protocol (AZA+CSA+S) to an MMF-based regimen (MMF+CSA+S) at our centre. To analyse the impact of this change in regimen, we have monitored 6-month patient and graft survival, rejection rate, serum creatinine and CSA levels, as well as the costs of the immunosuppressive and anti-rejection treatments, in 40 consecutive renal transplant recipients (MMF group) and have compared the data with 40 consecutive patients transplanted immediately prior to the change in regimen (AZA group). RESULTS: Recipient and donor characteristics were similar in the AZA and MMF groups. Patient survival (37/40; 92.5% in the AZA group vs 38/40; 95% in the MMF group), graft survival (36/40 vs 36/40; both 90%) and serum creatinine (137+/-56 vs 139+/-44 micromol/l) after 6 months were not significantly different. However, the rate of acute rejection episodes (defined as a rise in creatinine without other obvious cause and treated at least with pulse steroids) was significantly reduced with MMF from 60 to 20% (P=0.0005). The resulting cost for rejection treatment was lowered 8-fold (from sFr. 2113 to 259 averaged per patient) and the number of transplant biopsies was lowered > 3-fold in the MMF group. The cost for the immunosuppressive therapy was increased 1.5-fold with MMF (from sFr. 5906 to 9231 per patient for the first 6 months). CONCLUSIONS: The change from AZA to MMF resulted in a significant reduction in early rejection episodes, resulting in fewer diagnostic procedures and rehospitalizations. The optimal long-term regimen in terms of patient and pharmacoeconomic benefits remains to be defined. (+info)

Right atrial bypass grafting for central venous obstruction associated with dialysis access: another treatment option. (8/5787)

PURPOSE: Central venous obstruction is a common problem in patients with chronic renal failure who undergo maintenance hemodialysis. We studied the use of right atrial bypass grafting in nine cases of central venous obstruction associated with upper extremity venous hypertension. To better understand the options for managing this condition, we discuss the roles of surgery and percutaneous transluminal angioplasty with stent placement. METHODS: All patients had previously undergone placement of bilateral temporary subclavian vein dialysis catheters. Severe arm swelling, graft thrombosis, or graft malfunction developed because of central venous stenosis or obstruction in the absence of alternative access sites. A large-diameter (10 to 16 mm) externally reinforced polytetrafluoroethylene (GoreTex) graft was used to bypass the obstructed vein and was anastomosed to the right atrial appendage. This technique was used to bypass six lesions in the subclavian vein, two lesions at the innominate vein/superior vena caval junction, and one lesion in the distal axillary vein. RESULTS: All patients except one had significant resolution of symptoms without operative mortality. Bypass grafts remained patent, allowing the arteriovenous grafts to provide functional access for 1.5 to 52 months (mean, 15.4 months) after surgery. CONCLUSION: Because no mortality directly resulted from the procedure and the morbidity rate was acceptable, this bypass grafting technique was adequate in maintaining the dialysis access needed by these patients. Because of the magnitude of the procedure, we recommend it only for the occasional patient in whom all other access sites are exhausted and in whom percutaneous dilation and/or stenting has failed. (+info)

Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival ... This is a rather indirect GvHD because it is not directly cells in the graft itself that causes it but cells in the graft that ... Hale G, Waldmann H (May 1994). "Control of graft-versus-host disease and graft rejection by T cell depletion of donor and ... "Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T ...

https://en.wikipedia.org/wiki/Graft-versus-host_disease

Leitão, Cristiane (March 2010). "Lipotoxicity and Decreased Islet Graft Survival". Diabetes Care. 33 (3): 658-660. doi:10.2337/ ...

https://en.wikipedia.org/wiki/Lipotoxicity

"Corneal graft survival research and registry". Flinders University. Retrieved 7 April 2022. "Australian Corneal Graft Registry ... "Australian Corneal Graft Registry 10-Year Findings to Inform Future - mivision". 9 July 2018. Retrieved 7 April 2022. Weintraub ... Coster, D J; Williams, K A (2003-11). "Management of high-risk corneal grafts". Eye. 17 (8): 996-1002. doi:10.1038/sj.eye. ... She founded the Australian Corneal Graft Registry (ACGR) in 1985 and is currently the scientific director of the registry. The ...

https://en.wikipedia.org/wiki/Keryn_Williams

Thompson, RW Jr; Price, MO; Bowers, PJ; Price, FW Jr (2003-06-01). "Long-term graft survival after penetrating keratoplasty". ... PDEK graft is thicker than isolated DM graft and hence there is less intraoperative graft handling challenges like torn graft, ... Postoperative graft detachment can happen in eyes with insufficient air or loss of air after surgery.1,6 If the graft is ... The injector along with the graft is inserted via the corneal wound and the graft is injected in the anterior chamber (Fig 3C ...

https://en.wikipedia.org/wiki/Pre-Descemet's_endothelial_keratoplasty

Although short-term immunosuppression concerning patient and graft survival is found to be similar between the two drugs, ... McCauley, Jerry (19 May 2004). "Long-Term Graft Survival In Kidney Transplant Recipients". Slide Set Series on Analyses of ... and this may have important long-term implications given the prognostic influence of rejection on graft survival. Oral ... In people receiving immunosuppressants to reduce transplant graft rejection, an increased risk of malignancy (cancer) is a ...

https://en.wikipedia.org/wiki/Tacrolimus

Leto described This Is War as a record about survival: "It was a two-year creative battle that was ferocious and tough but ... Gary, Graff (December 17, 2009). "30 Seconds To Mars Plans To 'Extend The Interactivity' On Tour". Billboard. Retrieved August ... Harris, Chris (December 8, 2009). "30 Seconds To Mars Sing About Survival on "This Is War"". Rolling Stone. Retrieved August 29 ...

https://en.wikipedia.org/wiki/Thirty_Seconds_to_Mars

... graft survival, and visual outcome". The British Journal of Ophthalmology. 90 (3): 324-7. doi:10.1136/bjo.2005.079624. PMC ... The corneal epithelium is removed and a lenticule of donor cornea is grafted on top of it. The procedure requires a greater ... Research from two trials in Iran provide low to moderate evidence that graft rejection is more likely to occur in penetrating ... The corneal transplant surgeon trephines a lenticule of corneal tissue and then grafts the donor cornea to the existing eye ...

https://en.wikipedia.org/wiki/Keratoconus

"Kenya Graft Probe of Treasury Head Highlights Power Struggle". www.bloomberg.com. Herbling, David. "Schism in Kenya Ruling ... "Infighting threatens Jubilee Party's survival - Daily Nation". www.nation.co.ke. Retrieved 1 April 2019. Ombok, Eric; Herbling ...

https://en.wikipedia.org/wiki/Jubilee_Party

Alcohol and smoking can contribute to poor graft survival. Post operative antibiotics are commonly prescribed to prevent wound ... Hair transplantation differs from skin grafting in that grafts contain almost all of the epidermis and dermis surrounding the ... Modern transplant techniques began in Japan in the 1930s, where surgeons used small grafts, and even "follicular unit grafts" ... The average price per graft ranges between US$1.07 in Turkey up to US$7.00 in Canada. Some clinics also offer all-inclusive ...

https://en.wikipedia.org/wiki/Hair_transplantation

Patients who received successful bone marrow transplants had a 2-year survival rate of 68% and a 10-year survival rate of 64%. ... Patients can develop graft versus host disease; this is more likely in non-sibling donors. In a 1998 study, children with HLA- ... identical sibling donors had a 5-year survival of 75%; children with non-sibling donors had a 5-year survival of 53%. Children ... In these cases, UCBT from unrelated donors can increase survival, decrease physical signs of the disease, and improve cognition ...

https://en.wikipedia.org/wiki/Hurler_syndrome

T Davis and Joseph Pagkalos, published a paper on the effects of bearing surfaces on the survival of cementless and hybrid ... "Additional FDA Approval for Cerapedics i-FACTOR Bone Graft , Orthopedics This Week". Davis, Edward T.; Pagkalos, Joseph; Kopjar ... Peptide Enhanced Bone Graft. Since 2020, Dr. Kopjar has served as a consultant to the FDA's Orthopaedic and Rehabilitation ... "Predictive factors of survival in a surgical series of metastatic epidural spinal cord compression and complete external ...

https://en.wikipedia.org/wiki/Branko_Kopjar

Ptak W, Festenstein H, Asherson GL, Denman AM (1969). "Improved graft survival after treatment with Bordetella and anti- ...

https://en.wikipedia.org/wiki/Włodzimierz_Ptak

An Isograft is a graft of tissue between two individuals who are genetically identical (i.e. monozygotic twins). Transplant ... Effect of STZ Administration on Islet Isograft and Allograft Survival in NOD Mice. Diabetes Vol 42, February 1993. Retrieved 25 ... Furthermore, there is virtually no incidence of graft-versus-host disease. In 1993 a research article demonstrated that islet ...

https://en.wikipedia.org/wiki/Isograft

Graff 2015, p. 174. Peteet 1996, pp. 139-159. Ala Alazzeh, 'Abu Ahmad and His Handalas,' in Mark LeVine, Gershon Shafir (eds ... Struggle and Survival in Palestine/Israel, University of California Press 2012 pp.413-427 pp.424-5. Marouf Hasian and Lisa A. ... James A. Graff, in Tomis Kapitan (ed.), Philosophical Perspectives on the Israeli-Palestinian Conflict, M.E. Sharpe, 1997 pp. ... James A. Graff, 'Targeting Children,' in Tomis Kapitan (ed) Philosophical Perspectives on the Israeli-Palestinian Conflict, M.E ...

https://en.wikipedia.org/wiki/Palestinian_stone-throwing

Post-transplant hypertension at one year: Impact on long-term graft survival. Raju DSB, Agarwal SK, Gupta S, Dash SC, Bhowmick ...

https://en.wikipedia.org/wiki/Sree_Bhushan_Raju

"Causes of limited survival of microencapsulated pancreatic islet grafts". J. Surg. Res. 121 (1): 141-50. doi:10.1016/j.jss. ... grafted a solid, but permeable, shell around the cells to provide increased mechanical strength. Sodium Citrate is used for ... Approximately a doubling of survival time compared to historic controls was demonstrated. Questions could arise as to why the ... doi:10.1016/S0958-6946(96)00046-5. Kailasapathy K, Supriadi D (1996). "Effect of whey protein concentrate on the survival of ...

https://en.wikipedia.org/wiki/Cell_encapsulation

King, K. B., & Reis, H. T. (2012). Marriage and long-term survival after coronary artery bypass grafting. Health Psychology, 31 ...

https://en.wikipedia.org/wiki/Harry_Reis

... long-term graft survival is similar to recipients who receive ABOc kidneys. West, L. J., Karamlou, T., Dipchand, A. I., Pollock ... Graft survival and patient mortality is approximately the same between ABOi and ABOc recipients. This was found to not only ... Furthermore, should the recipient (for example, type B-positive with a type AB-positive graft) require eventual ... Does ABO-incompatible and ABO-compatible neonatal heart transplant have equivalent survival? Interactive cardiovascular and ...

https://en.wikipedia.org/wiki/ABO-incompatible_transplantation

Within the last few years, 1-year graft and patient survival at more experienced centers have reached 60% to 70% and 65% to 80 ... Surgical removal (excision or debridement) of the damaged skin is followed by skin grafting. The grafting serves two purposes: ... Higher graft and patient survival rates are seen at the more experienced transplant programs. ... Bone grafting is used to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or ...

https://en.wikipedia.org/wiki/Transplantable_organs_and_tissues

"Comparative Graft Survival Study of Follicular Unit Excision Grafts With or Without Minor Injury". Dermatologic Surgery. 47 (5 ... The hair follicle grouping or follicular unit is a full thickness skin graft containing epidermis, dermis and fat. The graft is ... transect grafts, rendering them useless in a transplant. FUE harvesting is a surgical technique of grafts and may cause "pit" ... The survival of follicular units upon cutting around the hair follicle and then extracting from the scalp is one of the key ...

https://en.wikipedia.org/wiki/Follicular_unit_extraction

"VEGF-trap Aflibercept Significantly Improves Long-term Graft Survival in High-risk Corneal Transplantation". Transplantation. ... Fuchsluger, T. A.; Jurkunas, U.; Kazlauskas, A.; Dana, R. (2011). "Anti-apoptotic gene therapy prolongs survival of corneal ... Class II-positive Dendritic Cells Derived from MHC Class II-negative Grafts". The Journal of Experimental Medicine. 195 (2): ... "Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment". The ...

https://en.wikipedia.org/wiki/Reza_Dana

Mehta V, Hong M, Spears J, Mendez I (June 1998). "Enhancement of graft survival and sensorimotor behavioral recovery in rats ... derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells". Neuroscience. 83 (2): 363-372 ... was translated into clinical trials in patients with Parkinson's disease and showed long-term survival of those grafts. He also ... He pioneered the technique of multiple grafts to restore dopamine input to the parkinsonian mammalian brain. This technique ...

https://en.wikipedia.org/wiki/Ivar_Mendez

However, there have been cases of survival. As of 2004, there were only two reported living cases. Of these two, one was ... Proceeding with a bone graft when the child reaches school age is also recommended. Usually babies with this malformation do ...

https://en.wikipedia.org/wiki/Acalvaria

1983) Grafting of burn patients with allografts of cultured epidermal cells. Lancet 2(8347): 428-430 (PMID 6135914) Halebian PH ... Corder VJ, Madden MR et al.. (1986) Improved burn center survival of patients with toxic epidermal necrolysis managed without ... 1983) Grafting of burn patients with allografts of cultured epidermal cells. Lancet 2(8347): 428-430 (PMID 6135914) Halebian PH ...

https://en.wikipedia.org/wiki/Tom_Shires

Bone grafting is necessary when there is a lack of bone. Also, it helps to stabilize the implant by increasing survival of the ... onlay bone grafting using the iliac crest or another large source of bone and microvascular bone graft where the blood supply ... various bone grafting techniques have been developed. The most frequently used is called guided bone graft augmentation where a ... Simonis P, Dufour T, Tenenbaum H (July 2010). "Long-term implant survival and success: a 10-16-year follow-up of non-submerged ...

https://en.wikipedia.org/wiki/Dental_implant

The grafted stock were given long-day and natural-day treatments. Survival was 70% to 100% and showed effects of rootstock and ... grafting Nut crops (walnut, pecan) - grafting Peach - grafting Pear - grafting Rubber Plant - bud grafting Rose - grafting ... grafting Grapes - stem cuttings, grafting, aerial layering Kumquat - stem cutting, grafting Mango- grafting, budding Maple - ... Proper care of graft site: After grafting, it is important to nurse the grafted plant back to health for a period of time. ...

https://en.wikipedia.org/wiki/Grafting

Graft survival and people's mortality is approximately the same between ABOi and ABO-compatible (ABOc) recipients. While focus ... Renal transplantation is more successful, with similar long-term graft survival rates to ABOc transplants. Until recently, ... Among his advances was the tubed pedicle graft, which maintained a flesh connection from the donor site until the graft ... Corneae and musculoskeletal grafts are the most commonly transplanted tissues; these outnumber organ transplants by more than ...

https://en.wikipedia.org/wiki/Organ_transplantation

January 1986). "Influence of the internal-mammary-artery graft on 10-year survival and other cardiac events". The New England ... with graft patency of 92% for all grafts and 100% for left internal thoracic artery grafts. Coronary artery bypass graft ... August 1989). "Internal mammary artery bypass grafting: influence on recurrent angina and survival in 2,100 patients". The ... Assessing survival and adverse cardiac events up to 8.0 years (average 2.9±2.0 years), MICS CABG is a safe, reproducible ...

https://en.wikipedia.org/wiki/Minimally_invasive_cardiac_surgery

At one-year, graft survival rates for isolated intestine currently waver around 80%, and 70% for intestine-liver and ... In a multivisceral graft, the stomach, duodenum, pancreas, and/or colon may be included in the graft. Multivisceral grafts are ... In the most basic and common graft, an isolated intestinal graft, only sections of the jejunum and ileum are transplanted. ... There are three major types of intestine transplants: an isolated intestinal graft, a combined intestinal-liver graft, and a ...

https://en.wikipedia.org/wiki/Intestine_transplantation

As survival following the procedure has increased, its use has expanded beyond cancer to autoimmune diseases and hereditary ... Infection and graft-versus-host disease are major complications of allogeneic HSCT. Hematopoietic stem cell transplantation ...

https://en.wikipedia.org/wiki/Haematopoietic_system

Graff, David (2003). Medieval Chinese Warfare 300-900. Warfare and History. Routledge. p. 57. ISBN 1134553536. Li, Shi. The ... The Eastern Jin, dependent on established southern nobility as well as exiled northern nobility for its survival, became a ...

https://en.wikipedia.org/wiki/Invasion_and_rebellion_of_the_Five_Barbarians

... which have lower rates of graft-versus-host disease. Antibodies are used to quantify and purify hematopoietic progenitor stem ... possible role in progenitor survival". Blood. 95 (3): 756-768. doi:10.1182/blood.V95.3.756. PMID 10648383.[permanent dead link ...

https://en.wikipedia.org/wiki/CD34

... and grafts. Unlike Medicare, which is solely a federal program, Medicaid is a joint federal-state program. Each state ... indicating that Medicaid accessibility led to early detection of breast cancer and higher survival rates. A 2020 study found no ...

https://en.wikipedia.org/wiki/Medicaid

Instead of trying to find a cure, Ngema switched his interest to try mass-producing the tumor for grafting onto mechanical ... as both girls were orphaned during the chaotic Martian wars and relied on each other for survival. They were subsequently ... However, as before, almost all his grafted babies failed to develop normal brains and had to be exterminated, until years later ... whom he claimed was the first case of a resected Maske Tumor developing a healthy brain after being grafted into an artificial ...

https://en.wikipedia.org/wiki/List_of_Battle_Angel_Alita:_Mars_Chronicle_characters

Madeleine had deliberately grafted the clock to his chest as a means of keeping him close to her, knowing that no adoptive ... Méliès states that Jack's clock heart was entirely unnecessary and the fact that Jack thought it was required for his survival ... grafts a cuckoo clock to his heart of flesh and blood in order to save it. Due to Madeleine's "clientele" the children that she ...

https://en.wikipedia.org/wiki/La_Mécanique_du_cœur_(novel)

"Victims absent from South Korea's 'comfort women' rally amid graft allegations over ex-leader". Reuters. May 20, 2020. Carmona- ... said that it fails to include the request from the survivals of sexual slavery to state the Japanese government's legal ...

https://en.wikipedia.org/wiki/Comfort_women

Frankenstein (played by the mustache-twirling Doktor Z) grafts round headlights and a seven-slot grill onto the face of a ... that would drive all but those truly devoted to its survival into the toolbox for a large ball-peen hammer." In Crap Cars, ...

https://en.wikipedia.org/wiki/List_of_automobiles_known_for_negative_reception

... painfully grafting each component until he passes out during neurosurgery. Waking up, Warren finds the facility in ruins, with ... but at a pace far too slow to ensure mankind's survival, along with unspecified long-term toxicity. Under pressure, the CREO ...

https://en.wikipedia.org/wiki/The_Surge

The five-year survival rate was 40%, which was twice that of untreated patients. However, post-operation morbidity rates were ... HALSTED, WILLIAM STEWART (1913-02-08). "Developments in the Skin-Grafting Operation for Cancer of the Breast". JAMA: The ... Neumann, Charles G.; Conway, Herbert (1948-01-01). "Evaluation of skin grafting in the technique of radical mastectomy in ... showed that there was no statistical difference in survival or recurrence between radical mastectomies and less invasive ...

https://en.wikipedia.org/wiki/Radical_mastectomy

... as coronary artery bypass grafting may be done at the same time Risk stratification for high cardiac risk surgeries (e.g., ... Persistent chest pain despite medical therapy thought to be cardiac in origin New-onset unexplained heart failure Survival of ... interventional cardiologist may opt instead to refer the patient to a cardiothoracic surgeon for coronary artery bypass graft ( ...

https://en.wikipedia.org/wiki/Cardiac_catheterization

It ranked higher in the categories of "economic participation and opportunity" and "health and survival", but very low in " ... S2CID 144161630.[permanent dead link] Hofenk de Graff, Judith H. (2004). The Colourful Past: Origins, Chemistry and ...

https://en.wikipedia.org/wiki/Belize

Graft, Kris (16 June 2016). "How emotional psychology and The Goonies inspired Sea of Thieves". Gamasutra. Archived from the ... While Rare is traditionally a console game developer, it realized how players from PC survival games like DayZ and Rust, and ...

https://en.wikipedia.org/wiki/Sea_of_Thieves

How these treatments compare with regard to overall survival or recurrence-free survival is unknown. Transurethral resection of ... Hjelmborg JB, Scheike T, Holst K, Skytthe A, Penney KL, Graff RE, et al. (November 2014). "The heritability of prostate cancer ... on survival. The tool provides patients with estimated survival rates after treatment in the context of absolute mortality rate ... The United States five-year survival rate is 98%. Globally, it is the second-most common cancer. It is the fifth-leading cause ...

https://en.wikipedia.org/wiki/Prostate_cancer

... improved survival of people with congenital athymia, and most people treated with this ... and graft versus host disease. It was approved for medical use in the United States in October 2021. Allogeneic processed ...

https://en.wikipedia.org/wiki/Allogeneic_processed_thymus_tissue

Graft damage during preparation and transportation Infection Hepatotoxic drugs Graft rejection Technical complications ( ... Mean survival was 25,2±34,6 days in the MARS group compared to 4,6±1,8 days observed in the controls in whom hemodiafiltration ... The study found that at the primary end-point 30-day post admission mark, there was an increased survival rate in BAL patients ... LTx is the only treatment that has shown an improvement in the prognosis and survival with most severe cases of ALF. ...

https://en.wikipedia.org/wiki/Liver_support_system

By 1937, Young reported a five-year survival rate of 50%. However, by the time the diagnosis of prostate cancer was made, it ... previous pelvic arterial bypass grafts or has a delayed recurrence of prostate cancer after salvage prostatectomy and ...

https://en.wikipedia.org/wiki/Radical_perineal_prostatectomy

The cult of Murukan was grafted onto the worship of Skanda-Kumara that was prevalent in Sri Lanka. Amongst the Sinhalese he ... the mode of veneration and rituals connected with Kataragama deviyo is a survival of indigenous Vedda mode of veneration that ...

https://en.wikipedia.org/wiki/Kataragama_temple

Small grafts are sprayed with chemicals. A warm, aerosol-based protection has been developed for older trees, by Sifter and ... Survival and growth in size and biomass of American Chestnut (Castanea dentata) seedlings under various silvicultural regimens ... On alkaline soils, chestnut trees can be grown by grafting them onto oak rootstocks. Recently cleared land is best avoided to ... Leaves do not roll up, but their feeding delays the growth of shoots and damages young graft-shoot hosts. Commercial ...

https://en.wikipedia.org/wiki/Chestnut

Graff 2015, pp. 157ff. Graff 2015, p. 170. Gallo & Marzano 2009, p. 10. Bar-Siman-Tov 2007, p. 20. Plaw 2016, p. 63. Peled 2006 ... Glock, Albert (Spring 1994). "Archaeology as Cultural Survival: The Future of the Palestinian Past". Journal of Palestine ... Graff 2015, pp. 168-169. Graff 2015, p. 167. Gleim 2015. Michaeli 2013, pp. 7-46. Michaeli 2013, p. 43. Michaeli 2013, p. 47. ... Graff 2015, p. 173. Sait 2004, p. 221. Abdullah 2017. Harel 2003. Cohen 2010b, p. 146. WCLAC 2015, pp. 4-5. The Guardian 12 Sep ...

https://en.wikipedia.org/wiki/Israeli_occupation_of_the_West_Bank

Xavier and Nick Fury keep his survival a secret, Xavier making Beast believe he is regularly visiting his family and the X-Men ... was able to perform brain surgery on the Red Skull to extract the fragment of Charles Xavier's brain that the Skull had grafted ...

https://en.wikipedia.org/wiki/Beast_(Marvel_Comics)

Emmanuel Akyeampong and Ama de-Graft Aikins, "Ghana at Fifty: reflections on independence and after", Transitions 98, 2008, ... Ensuring Survival: Disabled Urban Ghanaian Women's Negotiations of Church and Family Belonging", Disability Studies Quarterly ...

https://en.wikipedia.org/wiki/Women's_Manifesto_for_Ghana

Several studies have found fat grafting of the lip to be one of the best methods of maintaining a semi-permanent fuller and ... Long term survival for fat transplants: controlled demonstration. Aesthetic Plastic Surgery 2996; 19:421-425 Giovanie Botti, ...

https://en.wikipedia.org/wiki/Lip_augmentation

van den Berg ME, Castellote JM, de Pedro-Cuesta J, Mahillo-Fernandez I (August 2010). "Survival after spinal cord injury: a ... walking to some degree bypassing the injury In 2014 Darek Fidyka underwent pioneering spinal surgery that used nerve grafts, ... Improvements in care have been accompanied by increased life expectancy of people with SCI; survival times have improved by ...

https://en.wikipedia.org/wiki/Spinal_cord_injury

... which are grafted onto rigid, non-active materials. Thus, the team was able to develop a self-folding sample that could fold ... and the self-folded hydrogel-based tubes support cell survival for at least 7 days without any decrease in cell viability. ...

https://en.wikipedia.org/wiki/4D_printing

Yorke Medical Books (1986) New York, pages 245-255 Oswal D, Suddershan C D, Kay P H (1997) '23 years survival of a bovine ... 1972) "Results of aortic valve replacement with fascia lata and pericardial grafts", The Journal of Thoracic and Cardiovascular ... Results of aortic replacement with frame-supported fascia lata and pericardial grafts' Journal of Thoracic and Cardiovascular ...

https://en.wikipedia.org/wiki/Pericardial_heart_valves

The numerous hybrids are propagated mainly by grafting on to seedling rootstock. While plants grown from seed are more likely ... ISBN 978-90-5782-204-9. John 'Lofty' Wiseman SAS Survival Handbook, Revised Edition p. 240; William Morrow Paperbacks (2009) ...

https://en.wikipedia.org/wiki/Adenium_obesum

"Places of Painting: Survival of Mnemotechnics in Christian von Mechel's Gallery Arrangement in Vienna (1779-81)." In Memory and ... In Dresden he furthered his acquaintance with the Swiss painters Anton Graff and Adrian Zingg and finally settled in Berlin in ... D.J.Meyjers, Places of Painting: Survival of Mnemotechnics in Christian von Mechel's Gallery Arrangement in Vienna (1779-81). ...

https://en.wikipedia.org/wiki/Christian_von_Mechel

Skin-grafting is another important form of treatment for burns. However, age is a risk factor for unsuccessful grafting due to ... "Predicting survival in an elderly burn patient population". Burns: Journal of the International Society for Burn Injuries. 27 ( ... Other risk factors for failed skin relevant to the geriatric population for unsuccessful skin grafting include being over age ... "Predicting survival in an elderly burn patient population". Burns. 27 (6): 583-590. doi:10.1016/S0305-4179(01)00009-2. ISSN ...

https://en.wikipedia.org/wiki/Geriatric_trauma

Human trials using regulatory T cells to treat graft-versus-host disease have shown efficacy. Further work has shown that T ... cytokine production and cell survival. This would inhibit a cell's ability to perform apoptosis and stop its own cell cycle, ... Ohki H, Martin C, Corbel C, Coltey M, Le Douarin NM (August 1987). "Tolerance induced by thymic epithelial grafts in birds". ...

https://en.wikipedia.org/wiki/FOXP3

While this will inevitably lead to facial paralysis, safe removal of a malignant neoplasm is vital for patient survival. After ... tumor removal, the facial nerve can be reinnervated with techniques such as cross-facial nerve grafting, nerve transfers and ...

https://en.wikipedia.org/wiki/Facial_nerve_paralysis

Downloading a figure as powerpoint requires a browser with javascript support. Enable javascript and try again For help please contact [email protected] ...

https://www.jci.org/assets/223938/powerpoint

BOSTON-Pediatric renal graft survival has improved over time, researchers reported at the 2012 American Transplant Congress. ... Graft survival improvements were significantly greater in the first year after transplantation compared with beyond one year. ... BOSTON-Pediatric renal graft survival has improved over time, researchers reported at the 2012 American Transplant Congress. ... One-, five, and 10-year graft survival was 80.9%, 58.3%, and 44.5% for transplants performed in 1987 compared with 93.4%, 73.6 ...

https://www.renalandurologynews.com/home/conference-highlights/american-transplant-congress/pediatric-renal-graft-survival-improving/

... in the younger age group donors could have decreased the graft survival ultimately making it comparable with the graft survival ... First, the authors have determined the overall 5-year graft survival rate due to endothelial failure in all recipients. No ... eLetter Comment on: The impact of donor age and endothelial cell density on graft survival following penetrating keratoplasty ... eLetter Comment on: The impact of donor age and endothelial cell density on graft survival following penetrating keratoplasty ...

https://bjo.bmj.com/content/100/7/986.responses

The shorter the length of time grafts are outside the body before implanting the higher percentage survival rate. I have ... GRAFT SURVIVAL and Reducing time out of the body * graft survival length time out ... 1,145 FUE grafts (3,152 hairs) with Ray Konior, MD - August 2018 763 FUE grafts (2,094 hairs) with Ray Konior, MD - January ... The shorter the length of time grafts are outside the body before implanting the higher percentage survival rate. ...

https://www.hairrestorationnetwork.com/topic/35975-graft-survival-and-reducing-time-out-of-the-body/

Dive into the research topics of Transplantation: Neural networks for predicting graft survival. Together they form a unique ...

https://asu.pure.elsevier.com/en/publications/transplantation-neural-networks-for-predicting-graft-survival/fingerprints/

Dive into the research topics of Looking inward: The impact of operative time on graft survival after liver transplantation. ... Looking inward: The impact of operative time on graft survival after liver transplantation. ...

https://mayoclinic.pure.elsevier.com/en/publications/looking-inward-the-impact-of-operative-time-on-graft-survival-aft/fingerprints/

Survival of recipients of livers from donation after circulatory death who are relisted and undergo retransplant for graft ... Survival of recipients of livers from donation after circulatory death who are relisted and undergo retransplant for graft ...

https://experts.umn.edu/en/publications/survival-of-recipients-of-livers-from-donation-after-circulatory-/fingerprints/

The grafts were evaluated at 12 weeks post-transplantation. To detect the mechanism by which FE impacts graft survival, the ... whether FE could improve fat graft survival and whether FE and nanofat could work synergistically to promote fat graft survival ... FE could improve fat graft survival via proangiogenic, anti-apoptotic and pro-proliferative effects on ADSCs. FE plus nanofat- ... The grafts were evaluated at 2, 4 and 12 weeks post-transplantation. In the second animal study, nude mice were transplanted ...

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1290-1

Graft Survival. After graft placement, an initial adherence to the wound bed via a thin fibrin network temporarily anchors the ... These substances may be gently washed from the graft with saline following harvesting and do not compromise graft survival. [22 ... The vacuum assisted closure device: a method of securing skin grafts and improving graft survival. Arch Surg. 2002 Aug. 137(8): ... Graft Failure. Skin grafting may be unsuccessful for numerous reasons. The most common reason for skin graft failure is ...

https://emedicine.medscape.com/article/876290-overview

... and patient survival. Eight grafts were lost during the first six months after grafting in group 1, whereas only two grafts ... Graft survival was significantly longer in group 2 (hazard ratio, 0.5 [95% CI, 0.28-0.91]; p = 0.025). In a multivariate ... renal function and graft and patient survival were evaluated retrospectively. No significant difference was observed between ... were independent factors affecting graft survival. En bloc kidney transplantation from donors aged less than one year was ...

https://www.lidsen.com/journals/transplantation/transplantation-04-02-109

Suggested citation for this article: Johnson CJ, Graff R, Moran P, Cariou C, Bordeaux S. Breast Cancer Stage, Surgery, and ... Survival Time, y. Age-standardized Cause-Specific Survival, WHC-Linked Cancersb Age-standardized Cause-Specific Survival, ... a Cause-specific breast cancer survival is a net survival measure representing survival of a specified cause of death in the ... Survival calculations use actuarial method. Age standardized to the International Cancer Survival Standard 1, with age groups ...

https://www.cdc.gov/pcd/issues/2015/14_0439.htm

Patient and graft survival outcomes after 15 years support transplant benefits in HIV population. ... Kidney Transplant Patient Survival Lower, Graft Survival Similar For the kidney transplant analysis, 119 HIV-positive ... Graft survival among the kidney transplant patients was proportionally higher among HIV-positive patients after 15 years (75% ... Long-term data on those patients showed the acute rejection affected graft survival outcomes with kidney transplant recipients ...

https://www.medscape.com/viewarticle/966075

Early graft survival seen with HIV-positive deceased donor kidneys in positive recipients "Deceased donor kidney ... "Overall patients and graft [transplanted organ] survival were excellent and comparable, without evidence of increased serious ... Both groups had 100% survival during the follow-up period.. Delayed graft function - acute kidney injury requiring dialysis in ... kidney transplantation was safe and feasible and associated with excellent short-term patient survival and graft survival," ...

https://www.aidsmap.com/news/aug-2020/kidney-transplant-between-people-hiv-safe-says-us-study

In a matching cohort comprising 582 patients, death-censored graft survival, total CVE, and cardiac events were not different ... In a matching cohort comprising 582 patients, death-censored graft survival, total CVE, and cardiac events were not different ... In a matching cohort comprising 582 patients, death-censored graft survival, total CVE, and cardiac events were not different ... In a matching cohort comprising 582 patients, death-censored graft survival, total CVE, and cardiac events were not different ...

https://kyushu-u.pure.elsevier.com/ja/publications/effect-of-reninangiotensin-system-blockade-on-graft-survival-and-

The negative impact of DSA on patient and allograft survival is evident in adult and pediatric HT recipients. Many questions ... The negative impact of DSA on patient and allograft survival is evident in adult and pediatric HT recipients. Many questions ... with graft survival, development of antibody-mediated rejection and cardiac allograft vasculopathy (CAV). ... publications regarding the relevance of donor-specific HLA antibodies in adult and pediatric heart transplantation with graft ...

https://www.frontiersin.org/articles/10.3389/fimmu.2017.00004/full

Anatomical and functional graft survival, 10 years after epikeratoplasty in keratoconus.. Authors: Panda, Anita. Gupta, Anoop K ... Anatomical and functional graft survival, 10 years after epikeratoplasty in keratoconus. Indian Journal of Ophthalmology. 2013 ... Graft was clear in all but 1 eye at 10 year follow-up. Conclusion: Epikeratoplasty is a useful technique for keratoconic eyes ...

https://imsear.searo.who.int/handle/123456789/145338

The impact of disease recurrence on graft survival following liver transplanatation: a single centre experience. In: Transplant ... The impact of disease recurrence on graft survival following liver transplanatation: a single centre experience. / Rowe, IA; ... Dive into the research topics of The impact of disease recurrence on graft survival following liver transplanatation: a single ... The impact of disease recurrence on graft survival following liver transplanatation: a single centre experience. Transplant ...

https://research.birmingham.ac.uk/en/publications/the-impact-of-disease-recurrence-on-graft-survival-following-live

Primary outcome was a composite of patient and graft survival. We used univariate and multivariate models to evaluate ... PTA is associated with graft loss and mortality especially during the first three years. Anemia severity affects this ... PTA is associated with increased graft loss and in most studies with increased mortality. However, the effect of the severity ... Post renal transplant anemia: severity, causes and their association with graft and patient survival. *Amir Schechter1 na1, ...

https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-019-1244-y

This finding may have high clinical relevance, as liver grafts from extended DBD or DCD donors carry considerable risk … ... in the perfusate provides a fast prediction of liver graft function and loss during ex situ MP before implantation. ... Our series includes 100 HOPE-treated liver-transplanted patients with an overall tumor-censored 5-year graft survival of 89%. ... Objective: The aim of this study was to determine the predictive value of machine perfusate analysis on graft outcome. ...

https://pubmed.ncbi.nlm.nih.gov/31592808/

Researchers apply a new analytic method to research into corneal graft failures to establish factors that can help DSAEK graft ... Random Survival Forests Analysis Has Potential to Predict Keratoplasty Graft Success. Jodi McCaffrey, MA, FACHE ... Random survival forests ranked a DSAEK intraoperative complication as the third-most predictive factor of graft failure, after ... A new analytic method - random survival forests - can help evaluate which factors can predict if a graft will be successful ...

https://www.ophthalmologyadvisor.com/topics/cornea-ocular-surface/random-survival-forests-analysis-may-predict-dsaek-success/

... you can graft better fruit onto it such as peaches, nectarines and big plums. See what this Chickasaw plum graft yielded! ... Big sweet cultivated plums harvested off a Chickasaw plum graft. by David The Good June 22, 2015. July 24, 2015. ... In case you missed it, heres a video I recorded recently on this Chickasaw plum graft project. You can also see the nectarine ... Home Uncategorized Big sweet cultivated plums harvested off a Chickasaw plum graft ...

https://www.thesurvivalgardener.com/big-sweet-cultivated-plums-harvested/

Y graft. 6 mo. Survival at 4 y. 3. 67/M. Infrarenal aorta. 12.6/12.6. Enterobacter cloacae. AEF. Y graft. 6 mo. Survival at 3 y ... Y graft. 3 mo. Survival at 3 y. 5. 86/F. Thoracoabdominal aorta. Negative. MSSA. None. Medical treatment only. 3 mo. Survival ... Y graft (negative). 6 mo. Survival at 3 y. 3. 83/M. Infrarenal aorta. 86.5/160.8. ST18. Malignant lymphoma. EVAR (NA). 6 mo. ... Y graft. 6 mo. Survival at 4 y. 2. 74/M. Infrarenal aorta. Negative. Listeria monocytogenes. None. ...

https://wwwnc.cdc.gov/eid/article/28/7/21-2505-t2

To evaluate the role of flow cytometry crossmatching on graft survival in patients undergoing cadaveric renal retransplantation ... Improved Graft Survival in Cadaveric Renal Retransplantation by Flow Crossmatching. Paul W. Nelson, MD; Patty Eschliman; ... Results: Graft survival is significantly better (P=.03 [logrank test]) in regrafts when the flow crossmatch is used to select ... Improved Graft Survival in Cadaveric Renal Retransplantation by Flow Crossmatching. Arch Surg. 1996;131(6):599-603. doi:10.1001 ...

https://jamanetwork.com/journals/jamasurgery/article-abstract/596533

The implant survival rate does not differ between the two types of bone graft in a guided bone regeneration or in an autogenous ... Review of bone graft and implant survival rate : A comparison between autogenous bone block versus guided bone regeneration.. ... objective of this review is to compare the results of implant survival in an autogenous bone block compared to those in a graft ... The overall survival rate of implants was 97,9% in autogenous block (range 95.6-100%) and 98,5% (range 94.4-100%) in GBR. ...

https://pesquisa.bvsalud.org/odontologia/resource/pt/mdl-33930599

We have evaluated the possibility of promoting significantly allograft survival in a vascularized cardiac allograft model by ...

https://serval.unil.ch/en/notice/serval:BIB_03D6710BF252

Taurine improves graft survival after experimental liver transplantation. Mar 11, 2008. Click here to read the entire abstract ...

https://greenmedinfo.com/substance/taurine

Surgical complications did not significantly influence implant survival.",. keywords = "Grafts, Implant survival, Maxillary ... The prevalence of surgical complications of the sinus graft procedure and their impact on implant survival. In: Journal of ... The prevalence of surgical complications of the sinus graft procedure and their impact on implant survival. Journal of ... The prevalence of surgical complications of the sinus graft procedure and their impact on implant survival. / Schwartz-Arad, ...

https://cris.tau.ac.il/en/publications/the-prevalence-of-surgical-complications-of-the-sinus-graft-proce

Is Cadaveric Graft Survival Similar to Living Kidney Transplantation? ...

http://www.ijotm.com/ojs/index.php/IJOTM/article/view/92/167

The aim of this study was to document the block graft survival, complication and implant survival rate in a private practice ... Ten-year analysis of block graft survival, complication and implant survival rate in a private practice setting ... Add tags for Ten-year analysis of block graft survival, complication and implant survival rate in a private practice setting ... Post a Comment for Ten-year analysis of block graft survival, complication and implant survival rate in a private practice ...

http://digital.library.musc.edu/cdm/singleitem/collection/medica/id/723/rec/6

The effect on survival from the use of a saphenous vein graft during coronary bypass surgery: a large cohort study.. ... Saphenous vein graft (SVG) remains the predominant conduit used in coronary surgery. The internal mammary artery has higher ... Analyses of SVG ≥ 1 or SVG = 1 were compared to SVG = 0. Additionally, groups of 3, 4 or 5 grafts were subjected to multiple ... All matched analyses within restricted graft groups had increasing HR with increased number of SVG used. Any use of SVGs is ...

https://ahro.austin.org.au/austinjspui/handle/1/17902

Graft survival improvements were significantly greater in the first year after transplantation compared with beyond one year. (renalandurologynews.com)
The grafts were evaluated at 2, 4 and 12 weeks post-transplantation. (biomedcentral.com)
In the second animal study, nude mice were transplanted with a mixture of macrofat and nanofat, followed by intra-graft injection of FE at days 1, 7, 14, 21 and 28 post-transplantation. (biomedcentral.com)
However, the highly unpredictable absorption rate of grafted fats after fat transplantation reduces the efficacy of this method. (biomedcentral.com)
Co-transplantation of fat with proangiogenic growth factors (vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), etc.) has been proven to enhance the fat graft retention rate by increasing revascularization. (biomedcentral.com)
Buemi A, Duisit J, Musuamba F, Darius T, De Meyer M, Aydin S, Kanaan N, Devresse A, Goffin E, Mourad M. Donor Age and Ischemia Time Are Independent Factors Affecting Graft Survival after En Bloc Kidney Transplantation from Donors Less than Three Years of Age. (lidsen.com)
After transplantation, renal function and graft and patient survival were evaluated retrospectively. (lidsen.com)
En bloc kidney transplantation from donors aged less than one year was associated with high early graft loss and poor long-term survival rates. (lidsen.com)
The limited number of donors is a challenging problem to be faced to avoid long-term dialysis while awaiting kidney transplantation, which is the best treatment for end-stage renal disease and provides a higher quality of life and longer survival compared with long-term dialysis [ 1. Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999; 341: 1725-1730. [ CrossRef ] ">1 ]. (lidsen.com)
the Japan Academic Consortium of Kidney Transplantation (JACK) Investigators 2020, ' Effect of renin-angiotensin system blockade on graft survival and cardiovascular disease in kidney transplant recipients: retrospective multicenter study in Japan ', Clinical and Experimental Nephrology , vol. 24, no. 4, pp. 369-378. (elsevier.com)
Here, we review current publications regarding the relevance of donor-specific HLA antibodies (DSA) in adult and pediatric heart transplantation (HT) with graft survival, development of antibody-mediated rejection and cardiac allograft vasculopathy (CAV). (frontiersin.org)
Optimizing transplantation of allosensitized candidates using SAB and C1q-SAB methodology to prioritize the assignment of unacceptable antigens has allowed transplantation of highly allosensitized patients across the DSA barrier with survival rates comparable to DSA− heart transplant recipients ( 5 ). (frontiersin.org)
Inclusion criteria: all patients who underwent transplantation between the years 2002-2016, who had a functioning graft after six months, underwent a baseline anemia work-up at six months post-transplant, and a follow-up period of at least 12 months (i.e. 18 months from transplant). (biomedcentral.com)
In the field of liver transplantation, however, no studies exist on reliable prediction of graft function during MP. (nih.gov)
Graft survival is significantly better ( P =.03 [logrank test]) in regrafts when the flow crossmatch is used to select patients for transplantation. (jamanetwork.com)
Cadaver transplantation in Recent Era: Is Cadaveric Graft Survival Similar to Living Kidney Transplantation? (ijotm.com)
In a study lasting from 2007 to 2012, our pediatric liver transplant program showed a 100 percent five-year survival rate for related living donor liver transplantation. (hopkinsmedicine.org)
[ 2 ] These therapies have enabled the transplantation of and improved the survival of transplanted organs. (medscape.com)
recipient) and donor-recipient sex is associated with a higher risk of death-censored graft loss in kidney transplantation. (asnjournals.org)
For people with type 1 diabetes and end stage renal disease, simultaneous pancreas-kidney transplantation can improve kidney graft survival and result in prolonged insulin independence. (diabetes.ca)
Post-transplant diabetes is common after solid organ transplantation and is associated with increased risk for mortality, cardiovascular disease and graft loss. (diabetes.ca)
New cases of diabetes developing after solid organ transplantation-post-transplant diabetes mellitus (PTDM)-are common and associated with reduced patient and graft survival. (diabetes.ca)
End-stage kidney disease is the last stage of a chronic kidney disease, which if not addressed leads to premature death and, although it can be addressed by dialysis, kidney transplantation is the preferred treatment due to better survival rates, improved quality of life & cost efficiency. (europa.eu)
Heart transplantation (HTx) has become the preferred therapy for select patients, with a 1-year survival of almost 90% and a conditional half-life (the time at which 50% of patients who survived the first year are still alive) of 13 years. (medscape.com)
For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
Following pancreas transplantation, it is essential that any graft-related complications are diagnosed early to ensure prompt treatment and optimal survival of both graft and patient. (springeropen.com)
The graft transplantation has been used in kidney failure as reliable and effective treatment option since 1936 (1). (hvt-journal.com)
Studies show the increase in survival rate by transplantation in comparison to hemodialysis (2-4). (hvt-journal.com)
On the background of technological modernizations, surgical achievements, survival improvements the transplantation was further motivated by healthcare institutions. (hvt-journal.com)
Shortly, countries and transplantation centers demonstrates variation of survival estimations and risk ratios (2, 7, 8). (hvt-journal.com)
In this study, we investigated posttransplantational survival analysis of patients who underwent renal transplantation in Kyrgyzstan and other Eurasian, predominantly neighboring countries. (hvt-journal.com)
Besides the general analysis of survival after renal transplantation, analysis by transplantation years and differences among countries was also included in our study. (hvt-journal.com)
Renal transplantation has been an effective alternative as the treatment of Chronic Renal Disease, due to its cost effectiveness and the increase of the patients' survival. (bvsalud.org)
The development of cholangiopathies after liver transplantation impacts on the quality and duration of graft and patient survival, contributing to higher costs as numerous interventions are required to treat strictures and infections at the biliary tree. (journal-of-hepatology.eu)
We have also found in a number of different studies that the nucleated cell dose significantly affects transplant-related mortality, 1 , 3-5 survival, 1 , 3 and the speed as well as completeness of hematologic reconstitution after autologous 1 , 6 and allogeneic 3-5 transplantation for hematologic malignancies. (ashpublications.org)

First author Arya Zarinsefat, MD, of the Department of Surgery at UCSF, speculated that the lower long-term patient survival among HIV-positive kidney transplant recipients may reflect known cardiovascular risks among those patients. (medscape.com)
Similar to the kidney transplant recipients, the worst survival among all liver transplant subgroups was among HIV-HCV co-infected patients prior to access to HCV direct-acting antivirals in 2014, with a 5-year survival of 59.5% ( P = .04). (medscape.com)
The negative impact of DSA on patient and allograft survival is evident in adult and pediatric HT recipients. (frontiersin.org)
This finding may have high clinical relevance, as liver grafts from extended DBD or DCD donors carry considerable risks for recipients. (nih.gov)
Uninterrupted graft survival over 12 months was attained in 23 (68%) single and 47 (94%) (p =.002) two transplant recipients (separated by [median (IQR)] 6 (3-8) months). (kcl.ac.uk)
64% recipients of one or two transplants with uninterrupted function at 12 months sustained graft function at 6 years. (kcl.ac.uk)
Graft survival over the first 12 months was greater in recipients of two versus one islet transplant in the UK program, although function at 1 and 6 years was comparable. (kcl.ac.uk)
The purpose of this study was to determine if concurrent donor and recipient absolute weight and sex mismatch was associated with graft loss in a cohort of deceased donor kidney transplant recipients. (asnjournals.org)
Design, setting, participants, & measurements The association of kidney donor and recipient absolute weight and sex difference with death-censored graft loss was explored using a cohort of United States deceased donor recipients between 2000 and 2014 through the Scientific Registry of Transplants Recipients. (asnjournals.org)
Contrarily, reduced hyperfiltration injury and thereby reduced immune-mediated rejection and graft loss has been demonstrated in recipients of kidneys from relatively larger donors ( 8 , 9 ). (asnjournals.org)
Various research studies indicate that kidney transplant recipients experience an average weight gain of 5-10 kgs, which is linked to a reduction in patient survival and graft failure [ 5 - 7 ]. (medsci.org)
The effect of treatment of pre-transplant chronic hepatitis C virus infection on graft and survival in renal transplant recipients. (livhospital.com)
Transplant recipients receive life-long administration of immunosuppressive drugs that target T cell mediated graft rejection. (monash.edu)

With each successive year, the risk of graft loss decreased by 4%, after adjusting for possible confounders. (renalandurologynews.com)
In the first year post-transplant, the risk of graft loss decreased by 8% with each successive year, whereas beyond one year, the risk decreased by 2% with each successive year. (renalandurologynews.com)
There was no statistically significant difference in the risk of graft loss because of recurrent disease, when compared with PBC, for patients transplanted for alcohol related liver disease, nonalcoholic steatohepatitis and fulminant hepatic failure. (birmingham.ac.uk)
Recurrent disease, in part, explains the increased overall risk of graft loss in these groups. (birmingham.ac.uk)
Studies have demonstrated that a smaller donor size relative to recipient is associated with a higher risk of graft loss ( 5 - 7 ). (asnjournals.org)

This significantly reduces the time out of body in an attempt to increase graft survival rates. (hairrestorationnetwork.com)
In the first animal study, the weights of the fat grafts in the nanofat- and FE-treated groups were significantly higher than those of the fat grafts in the control group. (biomedcentral.com)
The patient survival rates at 15 years were not significantly different between the groups, at 70% for HIV-positive and 75.7% for HIV-negative, ( P = .12). (medscape.com)
Surgical complications did not significantly influence implant survival. (tau.ac.il)
A second study result which is also very important was that the haplo-cord patient group had significantly less graft versus host disease, only 5% in the haplo-cord group versus 40% in the MUD group. (parentsguidecordblood.org)
Conclusions: Women and men requiring arterial reconstruction for infrainguinal occlusive disease had comparable operative mortality and limb salvage rates, but long-term survival and graft patency were significantly reduced in women. (northwestern.edu)
High survival rate: the incisions fit perfectly, contact the cambium to the greatest extent, and significantly improve the survival rate. (solhoppa.com)
The CD20-positive group was significantly more likely to have steroid-resistant rejection and reduced graft survival compared to CD20-negative controls. (uab.edu)
In multivariate analysis, patients receiving the higher cell dose had a significantly better disease-free survival (relative risk 2.17, P = .045). (ashpublications.org)
1 The higher toxic death rate and poorer disease-free survival in patients receiving ≤2 × 10 8 nucleated cells/kg was only partially due to incomplete or delayed hematopoietic reconstitution with resultant increase in bleeding or infections because the cell dose did not affect the probability or rapidity of engraftment significantly in this group of 74 patients. (ashpublications.org)

The effect on survival from the use of a saphenous vein graft during coronary bypass surgery: a large cohort study. (austin.org.au)
Saphenous vein graft (SVG) remains the predominant conduit used in coronary surgery. (austin.org.au)
Any use of SVGs is independently associated with reduced survival after coronary artery bypass surgery. (austin.org.au)
Aortic replacement combined with coronary bypass surgery has an impact on the risk profile for the direct postoperative course and also on the long-time survival perspective. (clinicaltrials.gov)
In procedures where the aortic valve replacement (AVR) is combined with a coronary artery bypass graft (CABG), the use of a rapid deployment valve can shorten the duration of cardiac ischemia and the overall intervention duration, which possibly has an influence on clinical results. (clinicaltrials.gov)
As coronary artery bypass grafting (CABG) conduits, the saphenous veins have an 80-90% early patency rate, which decreases to 50% at 10 years. (medscape.com)
The RITA has a good patency rate when anastomosed to the LAD (96% at 1 year and 90% at 5 years) but a reduced rate when grafted to the circumflex or the right coronary artery (75% at 1 year). (medscape.com)
The usual incision for coronary artery bypass grafting (CABG) is a midline sternotomy (see the image below), although an anterior thoracotomy for bypass of the left anterior descending (LAD) artery or a lateral thoracotomy for marginal vessels may be used when an off-pump procedure is being performed. (medscape.com)
Analysis of Myocardial Ischemia Parameters after Coronary Artery Bypass Grafting with Minimal Extracorporeal Circulation and a Novel Microplegia versus Off-Pump Coronary Artery Bypass Grafting. (unibas.ch)
External nitinol meshing of venous coronary artery bypass grafts: is safety of application really in doubt? (unibas.ch)
Performance could be further improved by using summary risk prediction scores such as the EUROSCORE II for coronary artery bypass graft surgery or the GRACE risk score for acute coronary syndrome. (who.int)

PTA is associated with graft loss and mortality especially during the first three years. (biomedcentral.com)

The combined therapy did prolong the time during which the disease didn't get worse, what's known as progression-free survival - 7.4 months versus 4.6 months for those receiving only one agent. (rxwiki.com)
This could prolong graft survival and ensure organs are preserved long enough to be transplanted to patients in need. (lawsonresearch.ca)
Many experts consider melphalan plus prednisone to be standard therapy for L chain-type amyloidosis for patients not enrolled in a clinical trial, and it is the only regimen that has been shown to prolong survival compared with no chemotherapy. (medscape.com)

Assessment of flavin, a marker of mitochondrial complex I injury, in the perfusate provides a fast prediction of liver graft function and loss during ex situ MP before implantation. (nih.gov)

The long-term survival rate of block allografts as well implants placed into these sites along with the associated complications of these procedures have not been well documented . (musc.edu)
The most important challenge is to achieve the long-term survival of the transplanted organ. (europa.eu)
The key result of the study was that outcome measures were comparable between the two groups of patients: haplo-cord transplants are just as good as traditional MUD bone marrow transplants for long-term survival. (parentsguidecordblood.org)
Commentary: Multiple arterial grafting seems promising, but where is the proof of a long-term survival benefit in women? (elsevier.com)

Receiver-operating characteristic curve analysis revealed an area under the curve (AUROC) of 0.79 [95% confidence interval (CI), 0.62-0.97] for severe allograft dysfunction and for early graft loss (AUROC 0.93, 95% CI, 0.84-1.0). (nih.gov)
In places the word "graft" (or "allograft") is used for kidney transplant. (anzdata.org.au)
In 1944, Medawar showed that skin allograft rejection is a host versus graft response. (medscape.com)
However little is known of the impact on NK cells, which have the potential to be alloreactive in response to HLA-mismatched ligands on the lung allograft and in doing so, may impact negatively on allograft survival. (monash.edu)

Seven block allografts did not survive (survival rate 94.62%) . (musc.edu)
Block allografts present a suitable alternative to autogenous grafts without the need for a secondary surgical site . (musc.edu)
Allografts are grafts between members of the same species that differ genetically. (medscape.com)
Skin allografts or amnion grafts are effective burn-wound dressings and are within the reach of low- or medium-income countries. (who.int)
We undertook a study to ascertain the relationship between the presence of CD20-positive B-lymphocytes in renal allografts undergoing acute cellular rejection and graft survival. (uab.edu)

Method: We investigated 900 kidney transplant patients in a multicenter retrospective cohort study in Japan and compared death-censored graft survival and CVE (total, cardiac events, stroke) based on RASB use within 12 months after KT. (elsevier.com)
In a matching cohort comprising 582 patients, death-censored graft survival, total CVE, and cardiac events were not different between the two groups. (elsevier.com)

Review of bone graft and implant survival rate : A comparison between autogenous bone block versus guided bone regeneration. (bvsalud.org)
The objective of this review is to compare the results of implant survival in an autogenous bone block compared to those in a graft by guided bone regeneration . (bvsalud.org)
The implant survival rate does not differ between the two types of bone graft in a guided bone regeneration or in an autogenous bone block. (bvsalud.org)
Surgical complications of the procedure are rarely reported and their impact on implant survival has been investigated even to a lesser extent. (tau.ac.il)
The purpose of this study was to evaluate the prevalence of surgical complications of the sinus graft procedure and their impact on implant survival. (tau.ac.il)
However, no association was found between membrane perforations or postoperative complications and implant survival. (tau.ac.il)
Ten-year analysis of block graft survival, complication and implant survival rate in a private. (musc.edu)
The aim of this study was to document the block graft survival , complication and implant survival rate in a private practice setting . (musc.edu)
Implant survival was 91.33% with a mean follow up of 52.8 months (range 0.82 - 93.57 months) . (musc.edu)
The osteotome technique constitutes a reliable method with a long-term of 10 years presenting a high implant survival rate, suggesting an elevation up to 5.5 mm in healthy patients. (bvsalud.org)

Participates in NK cell-mediated bone marrow graft rejection. (dimabio.com)

The median observational period was 82 months, with 68 patients reaching graft loss: 79 total CVE, 36 cardiac events, 26 stroke. (elsevier.com)

ed tissues, the intensity of which and chemical alkylating agents are varies with the degree of antigenic considered to cause cancer primar- Immunosuppressive difference between graft and host. (who.int)

Kyle J. Van Arendonk, MD, and colleagues at Johns Hopkins University School of Medicine in Baltimore analyzed graft survival among 16,266 patients younger than 18 years who received a kidney-only transplant from 1987 to 2010. (renalandurologynews.com)
The Cancer Data Registry of Idaho (CDRI) is a population-based cancer registry that collects incidence and survival data on all cancer patients who reside in the state of Idaho or who are diagnosed or treated for cancer in the state (4). (cdc.gov)
Overall patients and graft [transplanted organ] survival were excellent and comparable, without evidence of increased serious adverse events of HIV-related complications such as breakthrough viremia, infectious hospitalizations, or opportunistic infections. (aidsmap.com)
At 15-years post-transplant, patient survival was 53.6% among the HIV-positive patients vs 79.6% for HIV-negative ( P = .03). (medscape.com)
To evaluate the role of flow cytometry crossmatching on graft survival in patients undergoing cadaveric renal retransplantation compared with our conventional antihuman globulin cytotoxic crossmatch. (jamanetwork.com)
Flow crossmatching improves graft survival in cadaveric renal retransplantation by identifying a subset of patients with donor-directed HLA class I antibodies that are not detectable by our conventional antihuman globulin crossmatch. (jamanetwork.com)
Methods: The study consisted of 70 patients who underwent 81 sinus graft procedures using the lateral wall approach from 1995 to 2000. (tau.ac.il)
Of the 70 patients, seven (10%) suffered from postoperative complications, specifically related to the sinus graft procedure, which included an uncommon cyst formation and an infection. (tau.ac.il)
Epidermal appendages are important sources of epithelial cells that re-epithelialize when the overlying epithelium is removed or destroyed in patients with partial thickness burns, abrasions, or split-thickness skin graft harvesting. (medscape.com)
Survival function probabilities of patients and rational risk factors of survival functions were evaluated by Kaplan-Meier and Cox regression analyses, respectively. (hvt-journal.com)
Female patients had longer graft survival times than males. (unideb.hu)
Design, Setting, and Participants: This decision analytical model examined US pediatric patients with kidney failure included in the US Renal Data System 2019 Report who were waiting for a kidney transplant, received a transplant, or experienced graft failure. (bvsalud.org)
The importance of colonoscopic findings in patients after renal graft. (livhospital.com)
Genetic variants of FOXP3 influence graft survival in kidney transplant patients. (cdc.gov)
Therefore, it is encouraging to see that increasing this number as much as possible improves survival by reducing transplant-related mortality in patients allografted from unrelated donors. (ashpublications.org)
The effect of cell dose on disease-free survival and transplant-related mortality in 85 AML patients allografted in first remission (cell numbers not available for two patients). (ashpublications.org)
A non-invasive standardised method for assessing bone marrow iron may provide important additional clinical information to assist in managing patients being considered for bone marrow transplant as severe complications such as graft versus host disease can, in some cases, become more severe and costly to manage than the original disease of the patient. (ferriscan.com)

Epidermal appendages play a critical role in re-epithelialization after epidermal or superficial dermal injury, including healing of split-thickness skin graft (STSG) donor sites. (medscape.com)
In a multivariate analysis, donor age ( p = 0.01) and ischemia time ( p = 0.02) were independent factors affecting graft survival. (lidsen.com)
Since keratoplasty became widely available in the 1950s, several studies have investigated the donor, recipient, and operative factors associated with graft survival after penetrating keratoplasty and, more recently, endothelial keratoplasty , including DSAEK. (ophthalmologyadvisor.com)
Serotonin innervation of the striatum may be derived from either the donor graft tissue or the normal host projections from the midbrain. (unboundmedicine.com)
Background and objectives Relatively smaller kidney donor to recipient size is proposed to result in higher graft loss due to nephron underdosing and hyperfiltration injury, but the potentially additive effect of sex and weight mismatch has not been explored in detail. (asnjournals.org)
Hyperfiltration due to reduced renal mass or nephron underdosing resulting from kidney size mismatch between donor and recipient has been proposed as a potential nonimmunologic contributor to chronic renal graft nephropathy ( 2 ). (asnjournals.org)
It takes a lot of dedication, commitment and work ethics to personally handle all the donor extraction and graft placement. (hairsite.com)
To ensure maximum survival of donor grafts, AHD uses hypotermosol solution to store the donor grafts, this is the same type of solution used for organ transplant and is better than the typical saline solution that is commonly used in the business. (hairsite.com)
Having both options available allows for more flexibility in safely extracting the donor follicles from the patient without damaging the grafts. (hairsite.com)
The donor pancreas is retrieved en bloc with the duodenum, which is transected and stapled proximally just beyond the pylorus and distally in the third part of the duodenum. (springeropen.com)
Step 1: keep the grafted stock in the grafting tool, press the handle to cut, and repeat this step to cut the stem of the donor. (solhoppa.com)

Early diagnosis and therapy for graft-related complications are essential for graft survival. (springeropen.com)

Autogenous bone is considered the gold standard in bone graft due to its biocompatibility, osteoinduction, osteoconduction and osteogenic properties. (bvsalud.org)
An alternative to autogenous bone grafting is the guided bone regeneration technique . (bvsalud.org)
The overall survival rate of implants was 97,9% in autogenous block (range 95.6-100%) and 98,5% (range 94.4-100%) in GBR. (bvsalud.org)
Autogenous vein grafts were performed in 90% of both groups. (northwestern.edu)

He underwent numerous skin grafts and surgeries as well as arduous physical rehabilitation over the next two years, and he lived 57 years after war's end, until 2002. (therecordnewspaper.org)

Is my rate of heart failure readmissions artery bypass graft (CABG) surgery, pneumonia and acute stroke). (who.int)

2. To evaluate the safety of the infusion of dimerizer drug, aP1903, to subjects who received BPX 501 and have developed Grade iii-iV acute Graft Versus Host Disease (GVHD), as well as to those subjects with Grade ii gut/liver acute GVHD or with Grade i/ii acute GVHD (skin only) who progress or do not respond within 7 days to standard of care treatment. (childrens.com)
there is a strong chance the patient will experience graft failure or terrible graft versus host disease. (parentsguidecordblood.org)

Most literature has emphasized the importance of immunologic mismatches ( 1 , 2 ), however, earlier studies have also demonstrated that nonimmunologic factors may influence graft and patient outcome ( 2 - 4 ). (asnjournals.org)

Primary outcome was a composite of patient and graft survival. (biomedcentral.com)
Data are scarce regarding the association between anemia severity with patient and graft outcome, as well as the distribution of specific etiologies for anemia and their association with outcomes. (biomedcentral.com)
The aim of this study was to determine the predictive value of machine perfusate analysis on graft outcome. (nih.gov)
On-line estimation of outcome before implantation would therefore substantially increase safe utilization of liver grafts. (nih.gov)
These outcome measures include overall survival, disease-free survival, and toxic-related deaths. (parentsguidecordblood.org)

Multivariate analysis indicated that female sex decreased secondary graft patency 2.4-fold and was the only variable associated with graft failure. (northwestern.edu)

To detect the mechanism by which FE impacts graft survival, the proangiogenic, anti-apoptotic and pro-proliferative activities of FE were analysed in grafts in vivo and in cultured human vascular endothelial cells (HUVECs), adipose-derived stem cells (ADSCs) and fat tissue in vitro. (biomedcentral.com)
With biocompatibility and a wide range of sources, autologous fat grafting has become one of the most commonly used methods for the treatment of soft tissue defects. (biomedcentral.com)
Autografts, which are grafts from one part of the body to another (eg, skin grafts), are not foreign tissue and, therefore, do not elicit rejection. (medscape.com)
Serotonin has been postulated to play a role in the transplant-induced involuntary movements that occur following intrastriatal grafts of ventral mesencephalic tissue in the treatment of Parkinson's disease. (unboundmedicine.com)
6. There is a higher survival rate for the tissue. (trans-hair.com)

Knowledge of these mechanisms is also critical in developing strategies to minimize rejection and in developing new drugs and treatments that blunt the effects of the immune system on transplanted organs, thereby ensuring longer survival of these organs. (medscape.com)
Data were collected as patient and graft survival rates, the prevalence of polycystic manifestation of the gastrointestinal tract and other organs, and the attendance of urinary tract infection. (unideb.hu)

A new analytic method - random survival forests - can help evaluate which factors can predict if a graft will be successful after Descemet stripping automated endothelial keratoplasty (DSAEK), according to findings published in JAMA Ophthalmology . (ophthalmologyadvisor.com)

A total of 212 screw-shaped implants were placed in the grafted sinuses and were restored by fixed prosthesis. (tau.ac.il)
Factors affecting the survival of implants placed in grafted maxillary sinuses: A clinical report. (bvsalud.org)

No significant difference was observed between the groups regarding recipient age, time on dialysis, ischemia time, human leukocyte antigen matching, the time needed to reach serum creatinine levels of ≤2 mg/mL, and patient survival. (lidsen.com)
We have excellent patient and graft survival rates . (hopkinsmedicine.org)
As always, the pros and cons of combination therapy should be discussed with the patient", Dr. van der Graff said. (rxwiki.com)
Studies have shown that, when looking at the 6 most important HLA types, cord blood transplants with only 4 of 6 HLA match are just as successful as bone marrow transplants that are 6 of 6 matched, in terms of long-term patient survival. (parentsguidecordblood.org)

PTA is associated with increased graft loss and in most studies with increased mortality. (biomedcentral.com)
Additionally, groups of 3, 4 or 5 grafts were subjected to multiple analyses testing the mortality hazard with increasing use of SVG. (austin.org.au)
From other factors influencing mortality, sex did not show strong impact on survival by Kaplan-Meier analysis, but significant association was found by Cox regression analysis. (hvt-journal.com)

Outcomes analysed in the research were overall survival, transplant failure, risk of infections and rebound in HIV viral load. (aidsmap.com)
Although findings are contradictory ( 10 ), sex mismatch has also been associated with worse graft outcomes after kidney transplant. (asnjournals.org)
To determine the impact of aortic root replacement (ARR) with a stentless bioprosthetic valve on midterm outcomes compared to a stented bioprosthetic valve-graft conduit. (semthorcardiovascsurg.com)

Grafting of mature scions onto rootstocks can result in fruiting in as little as two years. (wikipedia.org)

Furthermore, this weight increment contributes to an adverse cardiovascular risk profile and could be implicated in the pathogenesis of graft dysfunction. (medsci.org)

Following 56 months, Dr. van der Graff said there was no major difference in lifespan (overall survival) between the two groups. (rxwiki.com)
As a result of the fact that overall survival was not impacted, Dr. van der Graff does not recommend the combined chemotherapy regimen for people with advanced disease. (rxwiki.com)

For survival analysis the initial mode of dialysis is generally determined at 90 days after first treatment, to allow for early changes and maturation of access. (anzdata.org.au)
The "end point" studied was death for dialysis and graft survival for TxR. (bvsalud.org)

They found that the incidence of both acute and chronic graft-vs-host disease was noticeably lower in the BMT group. (medscape.com)

https://www.heart.org/en/health-topics/congenital-heart-defects/care-and-treatment-for-congenital-heart-defects/heart-transplant. (mayoclinic.org)

Skin grafting was first performed in India 2000 years ago but widespread interest did not develop until the 19th century. (medscape.com)
When looking at the survival curve, survival was nearly identical at 5 years, and only started to diverge at 10 years post-transplant," he noted. (medscape.com)
IMSEAR at SEARO: Anatomical and functional graft survival, 10 years after epikeratoplasty in keratoconus. (who.int)
We have used hypothermic oxygenated perfusion (HOPE) for donation after circulatory death (DCD) or extended criteria donation after brain death (DBD) human liver grafts during the last 7 years. (nih.gov)
The survival probability (P(s)) for HD at years 1, 3 and 5 was 87,5%, 72,6% and 57,8% respectively. (bvsalud.org)
The goal of this study was to evaluate by endoscopy, possible intercurrences during the sinus floor lifting employing the Summers technique, besides verify the implants' survival rate after 10 years. (bvsalud.org)
Over the last 17 years, liver transplant in India has evolved from a rarity to a common procedure available along the length and breadth of the country with survival data comparable to the best centres in the world. (mamcjms.in)

Isografts, which are grafts between genetically identical individuals (eg, monozygotic twins), also undergo no rejection. (medscape.com)

All matched analyses within restricted graft groups had increasing HR with increased number of SVG used. (austin.org.au)

Immunosuppressants also ensure the longer survival of the graft, but make the recipient susceptible to infections, such as fungi. (bvsalud.org)

Tape has been used to bind the rootstock and scion at the graft, and tar to protect the scion from desiccation. (wikipedia.org)
Multi-grafted trees have different varieties grafted onto one rootstock so you can enjoy more variety and extended harvests in one quarter the space. (groworganic.com)

The utilization of grafted tomato ( Solanum lycopersicum ) plants in the United States shows significant promise, particularly as intensively managed production systems like high tunnels and greenhouses become more popular. (ashs.org)

In the Cox multivariate analysis, the initial BMI, evaluated as a continuous variable continued to be an independent predictor of delayed graft function and chronic nephropathy. (medsci.org)

Anatomy23

Organisms15

Diseases44

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment95

Phenomena and Processes21

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science6

Named Groups5

Health Care33

Geographicals1

Autografting with philadelphia chromosome-negative mobilized hematopoietic progenitor cells in chronic myelogenous leukemia. (1/5787)

Organ-selective homing defines engraftment kinetics of murine hematopoietic stem cells and is compromised by Ex vivo expansion. (2/5787)

A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/mycophenolate mofetil in renal transplant recipients. (3/5787)

Bone marrow transplantation in pediatric patients with therapy-related myelodysplasia and leukemia. (4/5787)

Infrainguinal revascularisation in the era of vein-graft surveillance--do clinical factors influence long-term outcome? (5/5787)

A glial cell line-derived neurotrophic factor-secreting clone of the Schwann cell line SCTM41 enhances survival and fiber outgrowth from embryonic nigral neurons grafted to the striatum and to the lesioned substantia nigra. (6/5787)

Reduced kidney transplant rejection rate and pharmacoeconomic advantage of mycophenolate mofetil. (7/5787)

Right atrial bypass grafting for central venous obstruction associated with dialysis access: another treatment option. (8/5787)

Graft Survival

Kidney Transplantation

Graft Rejection

Survival Rate

Cell Survival

Tissue Donors

Immunosuppressive Agents

Liver Transplantation

Cadaver

Treatment Outcome

Transplantation, Homologous

Time Factors

Retrospective Studies

Living Donors

Pancreas Transplantation

Graft Occlusion, Vascular

Corneal Transplantation

Heart Transplantation

Survival Analysis

Keratoplasty, Penetrating

Tissue and Organ Procurement

Tacrolimus

Disease-Free Survival

Histocompatibility Testing

Immunosuppression

Skin Transplantation

Cyclosporine

Delayed Graft Function

Cold Ischemia

Follow-Up Studies

Islets of Langerhans Transplantation

Postoperative Complications

Organ Preservation

Survival

Mycophenolic Acid

Kaplan-Meier Estimate

Brain Death

Transplants

Transplantation Tolerance

Reoperation

Transplantation, Heterotopic

Graft Enhancement, Immunologic

Proportional Hazards Models

Liver Failure

Blood Vessel Prosthesis

Primary Graft Dysfunction

Antilymphocyte Serum

Death

Transplantation Immunology

Kidney Failure, Chronic

Risk Factors

Azathioprine

Rats, Inbred Lew

Isoantibodies

HLA Antigens

Polytetrafluoroethylene

Mice, Inbred C57BL

Organ Preservation Solutions

Mice, Inbred BALB C

Kidney

Multivariate Analysis

Recurrence

Donor Selection

Transplantation

Anastomosis, Surgical

Histocompatibility

Prospective Studies

Tissue and Organ Harvesting

Transplantation, Isogeneic

Corneal Neovascularization

Creatinine

Biopsy

Prognosis

Vascular Patency

Complement C4b

Age Factors

Raffinose

Isoantigens

Immunoconjugates

Cohort Studies