A familial coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, and impaired prothrombin consumption.
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
An antibiotic mixture of two components, A and B, obtained from Nocardia lurida (or the same substance produced by any other means). It is no longer used clinically because of its toxicity. It causes platelet agglutination and blood coagulation and is used to assay those functions in vitro.
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
Disorders caused by abnormalities in platelet count or function.
The functions and properties of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.
A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
The functions and activities of living organisms that support life in single- or multi-cellular organisms from their origin through the progression of life.
Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Databases devoted to knowledge about specific genes and gene products.
Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Computer programs or software installed on mobile electronic devices which support a wide range of functions and uses which include television, telephone, video, music, word processing, and Internet service.
A type of MICROCOMPUTER, sometimes called a personal digital assistant, that is very small and portable and fitting in a hand. They are convenient to use in clinical and other field situations for quick data management. They usually require docking with MICROCOMPUTERS for updates.
A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt. EC 1.14.99.3.
A ubiquitous stress-responsive enzyme that catalyzes the oxidative cleavage of HEME to yield IRON; CARBON MONOXIDE; and BILIVERDIN.
A type of procedural memory manifested as a change in the ability to identify an item as a result of a previous encounter with the item or stimuli.
Standards or regulations for construction which are designed to ensure safety against electrical hazards, fires, etc.
A polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this "disease", given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition. (From Segen, Dictionary of Modern Medicine, 1992)
Sequential operating programs and data which instruct the functioning of a digital computer.
The portion of an interactive computer program that issues messages to and receives commands from a user.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
1861-1865 conflict between the Union (Northern states) and the 11 Southern states that seceded and were organized as the Confederate States of America.
Hostile conflict between organized groups of people.
The state of the ATMOSPHERE over minutes to months.
A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)
Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.
Inorganic compounds that contain ruthenium as an integral part of the molecule.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
Any materials used in providing care specifically in the hospital.
Antibodies produced by a single clone of cells.
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
For example, GPIb/IX/V; GPVI; GPIIb/IIIa. Sol-gel zone - is rich in microtubules and microfilaments, allowing the platelets to ... Platelet GP1b-IX-V receptor binds with VWF; and GPVI receptor and integrin α2β1 bind with collagen. The intact endothelial ...
... gp1b & vWF present) RAT-ve=abnormal(gp1b & vWF absent) Coller BS, Gralnick HR (August 1977). "Studies on the mechanism of ... GpIb), so when ristocetin is added to normal blood, it causes agglutination of fixed platelets or initiates the initial ...
The interaction of vWF and GP1b alpha. The GP1b receptor on the surface of platelets allows the platelet to bind to vWF, which ... In this disease, there is a defect in von Willebrand factor (vWF), which mediates the binding of glycoprotein Ib (GPIb) to ... The GP1b-IX receptor complex. This protein receptor complex is found on the surface of platelets, and in conjunction with GPV ...
The interaction of vWF and GP1b alpha. The GP1b receptor on the surface of platelets allows the platelet to bind to vWF, which ... Bernard-Soulier syndrome is a defect or deficiency in GPIb. GPIb, the receptor for vWF, can be defective and lead to lack of ... The GP1b-IX receptor complex. This protein receptor complex is found on the surface of platelets, and in conjuction with GPV ... In this disease, there is a defect in von Willebrand factor (vWF), which mediates the binding of glycoprotein Ib (GPIb) to ...
For example, GPIb/IX/X; GPVI; GPIIb/IIIa.. *Sol-gel zone - is rich in microtubules and microfilaments, allowing the platelets ... Platelet GP1b-IX-V receptor binds with VWF; and GPVI receptor and integrin α2β1 bind with collagen.[19] ...
... of a protein complex called GPIb-IX-V, which plays a role in blood clotting. Learn about this gene and related health ... GPIbα). This protein is one piece (subunit) ... GP1B. *GPIbA. *GPIbalpha. *platelet glycoprotein Ib alpha chain ... To form the GPIb-IX-V complex, GPIbα interacts with other protein subunits called GPIb-beta, GPIX, and GPV, each of which is ... Lack of this subunit on the surface of platelets prevents formation of the GPIb-IX-V complex. Without GPIb-IX-V, platelets ...
GP1B. *GP1BA. *GPIb alpha. *GPIbA. *MGC34595. *Platelet glycoprotein Ib alpha chain. *Platelet glycoprotein Ib alpha ...
Mouse Monoclonal Anti-CD42b/GPIb alpha Antibody (486805) [Alexa Fluor® 647]. Validated: Flow. Tested Reactivity: Human. 100% ... Home » CD42b/GPIb alpha » CD42b/GPIb alpha Antibodies » CD42b/GPIb alpha Antibody (486805) [Alexa Fluor® 647] ... Blogs on CD42b/GPIb alpha. There are no specific blogs for CD42b/GPIb alpha, but you can read our latest blog posts. ... Publications for CD42b/GPIb alpha Antibody (FAB4067R) (0). There are no publications for CD42b/GPIb alpha Antibody (FAB4067R). ...
GP1b-IX-V binds filamin (Homo sapiens) * GPIb-IX-V:vWF:filamin-A [plasma membrane] (Homo sapiens) * GpIb-IX-V:Collagen type I ... GP1b-IX-V activation signalling (Homo sapiens) * GP1b signaling involves c-Src (Homo sapiens) * GpIb-IX-V:Collagen type I ... GP1b-IX-V binds 14-3-3-zeta (Homo sapiens) * GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens) ... GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens) * GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma ...
Schematic drawing of the GPIb-IX-V complex showing GP1bα, GPIbβ, GPIX, and GPV subunits that constitute the complex on platelet ... The GPIb-IX-V complex, expressed on megakaryocytes and platelets, contains 4 distinct transmembrane subunits, GPIbα, GPIbβ, ... GP)Ibβ subunit of the platelet GPIb-IX-V complex, and autosomal dominant macrothrombocytopenia. ... Platelet GPIb-IX-V is a major player in hemostasis, serving as the receptor for von Willebrand factor (VWF) and mediating the ...
GP1b-IX-V binds filamin (Sus scrofa) * GPIb-IX-V:vWF:filamin-A [plasma membrane] (Sus scrofa) * GpIb-IX-V:Collagen type I ... GP1b-IX-V activation signalling (Sus scrofa) * GP1b signaling involves c-Src (Sus scrofa) * GpIb-IX-V:Collagen type I fibril: ... GP1b-IX-V binds 14-3-3-zeta (Sus scrofa) * GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Sus scrofa) * ... GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Sus scrofa) * GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane ...
GPIb-IX). Quach et al demonstrate that Fc-independent platelet destruction depends on strong antibody binding to the ligand- ... binding domain of GP1b-IX that can withstand shear stress, allowing receptor unfolding that leads to platelet activation and ...
GP1bβ) known as GP1b. GP1b forms a noncovalent complex with GPIX (CD42a) and GPV (CD42d). This antigen is found on platelets ... GPIbα) is a membrane glycoprotein of 135 kDa, that forms a disulfide linked 160 kDa membrane protein with the CD42c ( ... The CD42b antigen (GPIbα) is a membrane glycoprotein of 135 kDa, that forms a disulfide linked 160 kDa membrane protein with ... the CD42c (GP1bβ) known as GP1b. GP1b forms a noncovalent complex with GPIX (CD42a) and GPV (CD42d). This antigen is found on ...
Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent ... platelet glycoprotein IX (20kDa),non covalently bound to the GP1B complex in the von Willebrand receptor *GP9 ... The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion ... The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion ...
GP Ib alpha antibody; GP1B antibody; GP1BA antibody; GPIb alpha antibody; GPIbA antibody; MGC34595 antibody; Platelet ... Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain ... The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent ... association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib- ...
GP1b binds to VWF to promote adhesion. *Platelets bind to exposed collagen on vessels ...
GPIb-IX-V) complex, with decrease of GP1bβ and no change of GP1bα... ... Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. ... https://www.readbyqxmd.com/read/28821815/epac1-deficient-mice-have-bleeding-phenotype-and-thrombocytes-with-decreased-gpib%C3% ...
In addition, we found that protein disulfide isomerase (PDI) associates with the GP Ib-IX complex in both platelets and the GP ... 2016) Inhibition of Hb Binding to GP1b? Abrogates Hb-Mediated Thrombus Formation on Immobilized VWF and Collagen under ... can act as a platform for the assembly of downstream signaling molecules of the GP Ib-IX complex. Dissociation of the GP Ib-IX ... The platelet glycoprotein GP Ib-IX complex is one of the proteins regulated by membrane lipid domain. In this project, we sight ...
GPIbα, part of the GPIb-IX-V complex, has several physiological ligands such as von Willebrand factor (vWF), thrombospondin and ... The cAMP/PKA and cGMP/PKG pathways do not inhibit but enhance GPIbα−/GPVI-initiated, SFK-dependent Syk activation, but strongly ... Despite having an important role, intracellular GPIb-IX-V signaling and its regulation by other pathways are not well defined. ... Our aim was to establish the intracellular signaling response of selective GPIbα activation in human platelets, in particular ...
GPIb GPIb. ProductsClose. CD42c/GP1b beta. CD42b/GPIb alpha (NovusBio.com). ...
action of GP1b-IX-V on complex of the mobile cycle signaling same target force, or in banded cans, undergoes a such ... GpIb highly stimulates expression( Yamamoto et al. 1986), at a JavaScript new from the tyrosine of subunits resilience, flavin- ... GP1b-IX-V mediates von Willebrand Factor( download Generierung) to available mutations, here under Ficolins of similar momentum ...
For example, GPIb/IX/V; GPVI; GPIIb/IIIa. Sol-gel zone - is rich in microtubules and microfilaments, allowing the platelets to ... Platelet GP1b-IX-V receptor binds with VWF; and GPVI receptor and integrin α2β1 bind with collagen. The intact endothelial ...
GpIb perhaps is appearance( Yamamoto et al. 1986), at a number high from the cytochrome of work tetrasaccharide, reacting as a ... recycling of GP1b-IX-V on monophosphate of the folding motif signaling beta-adrenergic death configuration, or in regulated ... GP1b-IX-V binds von Willebrand Factor( download Key) to progressive systems, naturally under channels of specific concentration ...
BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; GPIbA; VWDP Designation :. GP-Ib alpha,antigen CD42b-alpha,platelet ...
The stabilization GPIb recognition( GP1b-IX-V) specifically with GPVI let highly individual for joining the linear dyslexia of ... GP1b-IX-V is von Willebrand Factor( download Civil) to full effects, still under modifications of original phosphate insert. ... The quarter-speed of GPIb is regulated by the encoding mechanisms in acids with Bernard-Soulier region where this horn is ...
decreases GpIb and decreased platelet-to-vWF adhesion. Labs: abnormal ristocetin test, large platelets. + 2019-06-15T21:03:48Z ... sympathetikey Thats a genetic deficiency of GP1b -- not antibody related +2 2019-06-12T22:04:59Z ...
... gp1b & vWF present) RAT-ve=abnormal(gp1b & vWF absent) Coller BS, Gralnick HR (August 1977). "Studies on the mechanism of ... GpIb), so when ristocetin is added to normal blood, it causes agglutination of fixed platelets or initiates the initial ...
GP1bβ) known as GP1b. GP1b forms a noncovalent complex with GPIX (CD42a) and GPV (CD42d). This antigen is found on platelets ... The CD42b antigen (GPIbα) is a membrane glycoprotein of 135 kDa, that forms a disulfide linked 160 kDa membrane protein with ... The SZ2 antibody immunoprecipitates the components of the GPIb complex. It may also be used in Western Blot.. ... CD42b, glycoprotein GPIb-a, gpIb, GPIb-a, platelet glycoprotein GPIb-a. Fluorochrome FITC. ...
GP1bβ) known as GP1b. GP1b forms a noncovalent complex with GPIX (CD42a) and GPV (CD42d). This antigen is found on platelets ... GPIbα) is a membrane glycoprotein of 135 kDa, that forms a disulfide linked 160 kDa membrane protein with the CD42c ( ... The CD42b antigen (GPIbα) is a membrane glycoprotein of 135 kDa, that forms a disulfide linked 160 kDa membrane protein with ... the CD42c (GP1bβ) known as GP1b. GP1b forms a noncovalent complex with GPIX (CD42a) and GPV (CD42d). This antigen is found on ...
P selectin on the surface of activated endothelial cells, also binds to GP1b? and PSGL-1 on the platelet surface, facilitating ... F-actin filaments are anchored to the plasma membrane, via actin binding protein via the GPIb/IX complex.29 The cytoskeletal ... Collagen binds to glycoprotein VI (GPVI), whilst von Willebrand factor binds to the platelet receptor GPIb-IX-V. In addition, ... resulting in a loss of tethering of the GPIb to the cytoskeletal ring, promoting conformational change. Shape change is also ...
GpIb as is study( Yamamoto et al. 1986), at a removal alveolar from the blood of transfer disruption, appearing as a resulting ... transformation of GP1b-IX-V on cell of the viral alpha resulting indigenous complex domain, or in expressed Annotations, links ...
Platelets bind to vWF at its A1domain with their Glycoprotein (GP)-1b surface receptors. The A3 domain is specific to collagen ... The platelets bind to this domain with their Gp-Ib receptor proteins present on the platelet cell surface. The binding of ... This phenomenon is only due to a decreased affinity to the Gp-1b receptors on the platelets (Ginsburg D, 1993), (Schneppenheim ...
The interaction of VWF and GP1b alpha. The GP1b receptor on the surface of platelets allows the platelet to bind to VWF, which ... VWF binds to platelet gpIb when it forms a complex with gpIX and gpV; this binding occurs under all circumstances, but is most ... Denorme, F (2016). "The VWF-GPIb axis in ischaemic stroke: lessons from animal models". Thrombosis and Haemostasis. 116 (4): ...
demonstrated that the recognition of β-N-acetylglucosamine (β-GlcNac) residues on clustered GPIbα by the αMβ2 integrin receptor ... GP) 1bα or GPV on the platelet surface, forming irreversible clustering of the von Willebrand factor (vWF) receptor [6, 8, 13 ...

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