Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis.
A subclass of iridoid compounds that include a glycoside moiety, usually found at the C-1 position.
A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).
The above-ground plant without the roots.
A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone at C-17. They are aglycone constituents of CARDIAC GLYCOSIDES and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include DIGITOXIN and DIGOXIN and their derivatives and the STROPHANTHINS.
A group of 3-hydroxy-4-keto-FLAVONOIDS.
A subclass of iridoid compounds that include a glucoside moiety, usually found at the C-1 position.
Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms generally excreted in the urine.
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
A plant genus of the family RANUNCULACEAE that contains triterpenoid saponins. Remifemin from C. racemosa is used to suppress LUTEINIZING HORMONE. It is reclassified by some to ACTAEA. The common name of black snakeroot is also used with ASARUM and SANICULA.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.
Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.
The buttercup plant family of the order Ranunculales, subclass Magnoliidae, class Magnoliopsida. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.
A plant genus of the family ASTERACEAE. Members contain stevioside and other sweet diterpene glycosides. The leaf is used for sweetening (SWEETENING AGENTS).
A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.
An exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of GLUCOSE.
A group of FLAVONOLS based on kaempferol. They are derived from naringenin and can be hydroxylated to QUERCETIN or reduced to leucopelargonidin.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Cholestane derivatives containing a fused lactone ring at the 16,17-position and a spiroglycosidic linkage at C-22. Members include sarsaponin, DIOSGENIN and yamogenin.
A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.
The process of cleaving a chemical compound by the addition of a molecule of water.
A plant genus of the family ASCLEPIADACEAE. This is the true milkweed; APOCYNUM & EUPHORBIA hirta are rarely called milkweed. Asclepias asthmatica has been changed to TYLOPHORA.
A group of DITERPENES cyclized into four rings.
Enzymes which catalyze the endohydrolysis of 1,4-beta-D-xylosidic linkages in XYLANS.
A group of FLAVONOIDS characterized with a 4-ketone.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
The figwort plant family of the order Lamiales. The family is characterized by bisexual flowers with tubular corollas (fused petals) that are bilaterally symmetrical (two-lips) and have four stamens in most, two of which are usually shorter.
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
A genus of aerobic, gram-negative, motile, slightly curved, rod-shaped bacteria. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
Thirteen-carbon butene cyclohexene degradation products formed by the cleavage of CAROTENOIDS. They contribute to the flavor of some FRUIT. Ionone should not be confused with the similarly named ionol.
An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, lichenin, and cereal beta-glucans.
A group of phenyl benzopyrans named for having structures like FLAVONES.
A plant genus of the family CRASSULACEAE. Members contain rhodioloside. This roseroot is unrelated to the familiar rose (ROSA). Some species in this genus are called stonecrop which is also a common name for SEDUM.
The characteristic 3-dimensional shape of a carbohydrate.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
A group of enzymes that catalyze the hydrolysis of alpha- or beta-xylosidic linkages. EC 3.2.1.8 catalyzes the endo-hydrolysis of 1,4-beta-D-xylosidic linkages; EC 3.2.1.32 catalyzes the endo-hydrolysis of 1,3-beta-D-xylosidic linkages; EC 3.2.1.37 catalyzes the exo-hydrolysis of 1,4-beta-D-linkages from the non-reducing termini of xylans; and EC 3.2.1.72 catalyzes the exo-hydrolysis of 1,3-beta-D-linkages from the non-reducing termini of xylans. Other xylosidases have been identified that catalyze the hydrolysis of alpha-xylosidic bonds.
Polysaccharides consisting of xylose units.
The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.
A plant genus of the family OROBANCHACEAE. Members contain phenylethanoid glycosides.
The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)
A family of glycosidases that hydrolyse crystalline CELLULOSE into soluble sugar molecules. Within this family there are a variety of enzyme subtypes with differing substrate specificities that must work together to bring about complete cellulose hydrolysis. They are found in structures called CELLULOSOMES.
The morning glory family of flowering plants, of the order Solanales, which includes about 50 genera and at least 1,400 species. Leaves are alternate and flowers are funnel-shaped. Most are twining and erect herbs, with a few woody vines, trees, and shrubs.
Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The Madder plant family of the order Rubiales, subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.
Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
The characteristic three-dimensional shape of a molecule.
A plant genus of the family RUBIACEAE. Members contain genepin, from which geniposide is obtained for use as a crosslinking agent in ADHESIVES, and 3-caffeoyl-4-sinapoylquinic acid.
A plant genus of the family CORNACEAE. It is widely cultivated for the attractive flowers.
A plant genus of the family MYRTACEAE that bears an edible fruit and contains guavin B and quercetin glycosides.
A plant genus of the family ASCLEPIADACEAE. Members contain steroidal glycosides and cytotoxic phenanthroindolizidine N-oxide alkaloids.
Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
A plant genus of the family Plantaginaceae. Members contain scrosides (CINNAMATES) and phenylethanoid glycoside. P. kurrooa is the source of picroliv (a purified iridoid glycoside fraction from the roots having hepatoprotective, anti-inflammatory and antioxidant properties).
A plant genus of the family ARALIACEAE. Ciwujia extract, which is prepared from plants of this genus, contains ciwujianosides and is used to enhance PHYSICAL ENDURANCE.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)
A plant genus best known for edible underground tubers. Yam may also refer to a moist variety of sweet potato, IPOMOEA BATATAS.
3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. A cardenolide which is the aglycon of digitoxin. Synonyms: Cerberigenin; Echujetin; Evonogenin; Thevetigenin.
A plant genus of the family LILIACEAE that is a short plant with a distinct whorl of 3 broad leaves.
The milkweed plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida. It includes many tropical herbs and shrubby climbers; most with milky juice. Flowers have five united petals. Fruits are podlike, usually with tufted seeds.
The outer layer of the woody parts of plants.
A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.
Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS.
The aglucon moiety of a saponin molecule. It may be triterpenoid or steroid, usually spirostan, in nature.
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A flavanone glycoside found in CITRUS fruit peels.
Seedless nonflowering plants of the class Filicinae. They reproduce by spores that appear as dots on the underside of feathery fronds. In earlier classifications the Pteridophyta included the club mosses, horsetails, ferns, and various fossil groups. In more recent classifications, pteridophytes and spermatophytes (seed-bearing plants) are classified in the Subkingdom Tracheobionta (also known as Tracheophyta).
A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.
A species of gram-positive, thermophilic, cellulolytic bacteria in the family Clostridaceae. It degrades and ferments CELLOBIOSE and CELLULOSE to ETHANOL in the CELLULOSOME.
A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.
A plant genus of the family PYROLACEAE. The common name of wintergreen is more often used for GAULTHERIA.
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
The parts of plants, including SEEDS.
The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters. Asclepiadacea (formerly the milkweed family) has been included since 1999 and before 1810.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A semisynthetic digitalis glycoside with the general properties of DIGOXIN but more rapid onset of action. Its cardiotonic action is prolonged by its demethylation to DIGOXIN in the liver. It has been used in the treatment of congestive heart failure (HEART FAILURE).
A plant genus in the family CAPRIFOLIACEAE known for elderberries.
A group of 4-keto-FLAVONOIDS.
A plant genus of the family OLEACEAE. Members contain suspensaside.
A genus of toxic herbaceous Eurasian plants of the Plantaginaceae which yield cardiotonic DIGITALIS GLYCOSIDES. The most useful species are Digitalis lanata and D. purpurea.
A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A cyanogenic glycoside found in the seeds of Rosaceae.
The aglycone constituents of CARDIAC GLYCOSIDES. The ring structure is basically a cyclopentanoperhydrophenanthrene nucleus attached to a lactone ring at the C-17 position.
A hexosaminidase with specificity for terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides.
A plant genus of the family SOLANACEAE. Members contain SOLANACEOUS ALKALOIDS. Some species in this genus are called deadly nightshade which is also a common name for ATROPA BELLADONNA.
A plant genus of the family LILIACEAE. Members contain the cardiotonic PROSCILLARIDIN. The common name of squill is also used for URGINEA.
A plant genus of the family RANUNCULACEAE that contains aquiledine, isoaquiledine and cycloartane-type glycosides.
The rose plant family in the order ROSALES and class Magnoliopsida. They are generally woody plants. A number of the species of this family contain cyanogenic compounds.
Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)

Proteoglycan involvement in polyamine uptake. (1/2075)

We have evaluated the possible role of proteoglycans in the uptake of spermine by human lung fibroblasts. Exogenous glycosaminoglycans behaved as competitive inhibitors of spermine uptake, the most efficient being heparan sulphate (Ki=0.16+/-0.04 microM). Treatment of fibroblasts with either heparan sulphate lyase, p-nitrophenyl-O-beta-D-xylopyranoside or chlorate reduced spermine uptake considerably, whereas chondroitin sulphate lyase had a limited effect. Inhibition of polyamine biosynthesis with alpha-difluoromethylornithine resulted in an increase of cell-associated heparan sulphate proteoglycans exhibiting higher affinity for spermine. The data indicate a specific role for heparan sulphate proteoglycans in the uptake of spermine by fibroblasts. Spermine uptake by pgsD-677, a mutant Chinese hamster ovary cell defective in heparan sulphate biosynthesis, was only moderately reduced (20%) compared with wild-type cells. Treatment of mutant cells with the above-mentioned xyloside resulted in a greater reduction of endogenous proteoglycan production as well as a higher inhibition of spermine uptake than in wild-type cells. Moreover, treatment with chondroitin sulphate lyase resulted in a selective inhibition of uptake in mutant cells, indicating a role for chondroitin/dermatan sulphate proteoglycans in the uptake of spermine by these cells. Fibroblasts, made growth-dependent on exogenous spermine by alpha-difluoromethylornithine treatment, were growth-inhibited by heparan sulphate or beta-D-xyloside, which might have future therapeutical implications.  (+info)

Determining anomericity of the glycosidic bond in Zn(II)-diethylenetriamine-disaccharide complexes using MSn in a quadrupole ion trap. (2/2075)

Zinc-diethylenetriamine (Zn-dien) N-glycoside complexes of four 1,4 and four 1,6 linked disaccharides are prepared. Each reaction mixture is ionized by electrospray and the resulting species [Zn(dien)(disaccharide)-H]+ is allowed to undergo collision-induced dissociation in a quadrupole ion trap. An MS3 analysis is used to differentiate alpha versus beta anomericity of the glycosidic bond in the disaccharide moiety. In addition, the MS2 and MS3 spectra can be used together to determine the linkage position of this glycosidic bond.  (+info)

Characterization of a novel unconjugated pteridine glycoside, cyanopterin, in Synechocystis sp. PCC 6803. (3/2075)

A new pteridine glycoside, called cyanopterin, was isolated from Synechocystis sp. PCC 6803 and its structure was elucidated as 6-[1-(4-O-methyl-(alpha-d-glucuronyl)-(1, 6)-(beta-d-galactosyloxy]methylpterin by chemical degradation and 1H- and 13C-NMR spectroscopic means. Cyanopterin is constitutively synthesized at a relatively high intracellular concentration that is comparable to that of chlorophyll a in a molar ratio of approximately 1 to 1.6. The in vivo oxidation state of cyanopterin is primarily the fully reduced 5,6,7,8-tetrahydro form. The cellular function is unknown at present. The findings have established a model system, using Synechocystis sp. PCC 6803, for studies of the physiological functions of unconjugated pteridine glycosides found mostly in cyanobacteria.  (+info)

Collagen synthesis and deposition in cartilage during disrupted proteoglycan production. (4/2075)

A simple system was developed to investigate in vitro the possible relationship between collagen and proteoglycan synthesis in cartilage. When production of complete proteoglycan molecules was effectively inhibited with 4-methylumbelliferyl beta-D-xyloside collagen synthesis and distribution were virtually unaffected.  (+info)

Stimulation of collagen galactosyltransferase and glucosyltransferase activities by lysophosphatidylcholine. (5/2075)

Lysophosphatidylcholine stimulated the activities of collagen galactosyl- and glucosyl-transferases in chick-embryo extract and its particulate fractions in vitro, whereas essentially no stimulation was noted in the high-speed supernatant, where the enzymes are soluble and membrane-free. The stimulatory effect of lysophosphatidylcholine was masked by 0.1% Triton X-100. In kinetic experiments lysophosphatidylcholine raised the maximum velocities with respect to the substrates and co-substrates, whereas no changes were observed in the apparant Km values. Phospholipase A preincubation of the chick-embryo extract resulted in stimulation of both transferase activities, probably gy generating lysophosphatides from endogenous phospholipids. No stimulation by lysophosphatidylcholine was found when tested with 500-fold-purified glycosyltransferase. The results suggest that collagen glycosyltransferases must be associated with the membrane structures of the cell in order to be stimulated by lysophosphatidylcholine. Lysophosphatidylcholine could have some regulatory significance in vivo, since its concentration in the cell is comparable with that which produced marked stimulation in vitro.  (+info)

Initiation of galactosaminoglycan biosynthesis. Separate galactosylation and dephosphorylation pathways for phosphoxylosylated decorin protein and exogenous xyloside. (6/2075)

By using various radiolabelled precursors, glycosylation and phosphorylation of decorin in a rat fibroblast cell line was investigated in the presence of increasing concentrations of p-nitrophenyl-O-beta-d-xylopyranoside. Decorin core protein glycanation was suppressed to approximately 25% of the normal level in the presence of 2 mm and 3 mm xyloside. Glycans/saccharides were released from the core protein and size-separated by gel chromatography. The intracellular decorin obtained from cells treated with 2 mm xyloside was substituted with Xyl and also with Gal-Xyl and Gal-Gal-Xyl, but not with longer saccharides. Only the trisaccharide contained an almost fully phosphorylated Xyl. We conclude that galactosylation of endogenous, xylosylated decorin and exogenous xyloside probably follow separate pathways or that xylosides and early decorin glycoforms are kept separated. At the addition of the first glucuronic acid the two pathways seem to merge and dephosphorylation of decorin takes place. Xyloside-primed and secreted galactosaminoglycan chains produced simultanously retained phosphorylated Xyl. Inadequate dephosphorylation could be due to excess substrate or to a short transit.time. As shown previously [Moses, J., Oldberg, A., Eklund, E. & Fransson, L.-A. (1997) Eur. J. Biochem. 248, 767-774], brefeldin A-arrested decorin is substituted with the linkage-region extended with an undersulphated and incomplete galactosaminoglycan chain. In cells treated with this drug, xylosides were unable to prime galactosaminoglycan synthesis and unable to inhibit glycosylation and phosporylation of decorin.  (+info)

Fusicoccin, 14-3-3 proteins, and defense responses in tomato plants. (7/2075)

Fusicoccin (FC) is a fungal toxin that activates the plant plasma membrane H+-ATPase by binding with 14-3-3 proteins, causing membrane hyperpolarization. Here we report on the effect of FC on a gene-for-gene pathogen-resistance response and show that FC application induces the expression of several genes involved in plant responses to pathogens. Ten members of the FC-binding 14-3-3 protein gene family were isolated from tomato (Lycopersicon esculentum) to characterize their role in defense responses. Sequence analysis is suggestive of common biochemical functions for these tomato 14-3-3 proteins, but their genes showed different expression patterns in leaves after challenges. Different specific subsets of 14-3-3 genes were induced after treatment with FC and during a gene-for-gene resistance response. Possible roles for the H+-ATPase and 14-3-3 proteins in responses to pathogens are discussed.  (+info)

Characterization of the UDP-glucuronosyltransferases involved in the glucuronidation of an antithrombotic thioxyloside in rat and humans. (8/2075)

To investigate the glucuronidation on the hydroxyl group of carbohydrate-containing drugs, the in vitro formation of glucuronides on the thioxyloside ring of the antithrombotic drug, LF 4.0212, was followed in rat and human liver microsomes and with recombinant UDP-glucuronosyltransferases (UGT). The reaction revealed a marked regioselectivity in rat and humans. Human liver microsomes glucuronidated the compound mainly on the 2-hydroxyl position of the thioxyloside ring, whereas rat was able to form glucuronide on either the 2-, 3-, or 4- hydroxyl group of the molecule, although to a lower extent. LF 4.0212 was a much better substrate of human UGT than the rat enzyme (Vmax/Km 30.0 and 0.06 microl/min/mg, respectively). Phenobarbital, 3-methylcholanthrene, and clofibrate enhanced the glucuronidation of LF 4.0212 on positions 2, 3, and 4 of the thioxyloside ring, thus indicating that several UGT isoforms were involved in this process. The biosynthesis of the 2-O-glucuronide isomer was catalyzed by the human UGT1A9 and 2B4, but not by UGT1A6 and 2B11. By contrast, the rat liver recombinant UGT1A6 and 2B1 failed to form the 2-O-glucuronide isomers. From all the recombinant UGTs tested, none catalyzed the formation of the 3-O-glucuronide isomer. Interestingly, glucuronidation on the 4-position was found in all the metabolic competent V79 cell lines considered, including the nontransfected V79 cells, suggesting the presence of an endogenous UGT in fibroblasts able to actively glucuronidate the drug. This activity, which was nonsensitive to the inhibitory effect of 7,7,7-triphenylheptanoic acid, a potent UGT inhibitor, could reflect the existence of a different enzyme.  (+info)

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TY - JOUR. T1 - Inhibition of rat brain Na+-K+-ATPase by triterpene glycosides from holothurians. AU - Gorshkova, I. A.. AU - Gorshkov, B. A.. AU - Stonik, V. A.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - I. A. Gorshkova, B. A. Gorshkov and V. A. Stonik. Inhibition of rat brain Na+-K+-ATPase by triterpene glycosides from holothurians. Toxicon 27, 927-936, 1989.-The effect of triterpene glycosides from holothurians on Na+-K+-ATPase of rat brain was investigated. The marine glycosides are irreversible inhibitors of the enzyme with an average I50 value of 10-4 M. ATP had a low protective effect against inhibition. The inhibitory effect was increased by preincubation with MgCl2. There was alteration of the activation curve of Na+-K+-ATPase by NaCl and KCl in the presence of glycosides. Triterpene glycosides inhibited the K+-phosphatase activity, but to a smaller degree than the ATPase activity. Na+-K+-ATPase of pig kidney was less sensitive to the marine triterpene glycosides than the brain enzyme. The ...
3-O-beta-d-glucopyranosyl (1-6)-beta-d-glucopyranosyl, 28-O-beta-d-glucopyranosyl (1-6) (alpha-l-rhamnopyranosyl (1-2))-beta-d-glucopyranosyl, 16-deoxybarringtogenol ...
TY - JOUR. T1 - Alpha- and beta-xylosides modulate the synthesis of fibronectin and thrombospondin-1 by endothelial cells. AU - Canfield, A E. AU - Sutton, A B. AU - Hiscock, D R. AU - Gallagher, J T. AU - Schor, A M. PY - 1994/8/18. Y1 - 1994/8/18. N2 - We have previously shown that both p-nitrophenyl-alpha-D-xylopyranoside (alpha-xyloside) and p-nitrophenyl-beta-D-xylopyranoside (beta-xyloside) inhibit endothelial morphogenesis in vitro. In order to determine the mechanism for this inhibition, we have now investigated the effects of these compounds on the synthesis of proteoglycans and proteins by bovine aortic endothelial cells. Consistent with their well-recognised modes of action, beta-xyloside, but not alpha-xyloside, enhanced the secretion of free glycosaminoglycans into the medium. Furthermore, although both xylosides inhibited proteoglycan deposition into the cell layer/matrix, only beta-xyloside altered the nature of the proteoglycans synthesised by the cells. Both alpha- and ...
But, of course, glucosides are glycosides.. Glycosides are constituents bound to a sugar, and in a glucoside the sugar is glucose. In a fructoside the sugar is fructose, in a galactoside the sugar is galactose (dunno how youd get milk sugar into a plant, though), and so on.. Because of that sugar glycosides usually start working in the gut, after the sugar has been stripped away.. Glycosides are water- and alcohol-soluble.. The cyanoglycosides are found in most if not all rose family plants. You get cyanide from cyanoglycosides; theyll stop you breathing if you ingest large enough amounts of them.. Youll find heart glycosides in foxglove (Digitalis spp.) and a lot of other plants which act on the heart. The glycosides digitoxin, digitalein, digitonin, digitalin and so on are cumulative and toxic; they work in doses rather too close to the deadly dose, and they will kill people who regularly take them -- if these folks suddenly get much weaker. The thing is, though, that without these toxic ...
TY - JOUR. T1 - Two different modes of inhibition of the rat brain Na+, K+-ATPase by triterpene glycosides, psolusosides A and B from the holothurian Psolus fabricii. AU - Gorshkova, Irina A.. AU - Kalinin, Vladimir I.. AU - Gorshkov, Boris A.. AU - Stonik, Valentin A.. PY - 1999/1/1. Y1 - 1999/1/1. N2 - Effects of two triterpene glycosides, isolated from the holothurian Psolus fabricii, on rat brain Na+, K+-ATPase (Na, K-pump; EC 3.6.1.3) were investigated. Psolusosides A and B (PsA and PsB) inhibited rat brain Na+, K+-ATPase with I50 values of 1 x 10-4 M and 3 x 10-4 M, respectively. PsA significantly stimulated [3H]ATP binding to Na+, K+-ATPase, weakly increased [3H]ouabain binding to the enzyme, and inhibited K+-phosphatase activity to a smaller degree than the total reaction of ATP hydrolysis. In contrast, PsB decreased [3H]ATP binding to Na+, K+-ATPase, and had no effect on [3H]ouabain binding to the enzyme. K+-Phosphatase activity was inhibited by PsB in parallel with Na+, K+-ATPase ...
TY - CHAP. T1 - Enzymatic Approaches to O-Glycoside Introduction. T2 - Glycosyltransferases. AU - Chokhawala, H. A.. AU - Chen, Xi. PY - 2007/1/1. Y1 - 2007/1/1. UR - http://www.scopus.com/inward/record.url?scp=79951603384&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=79951603384&partnerID=8YFLogxK. U2 - 10.1016/B978-044451967-2/00012-X. DO - 10.1016/B978-044451967-2/00012-X. M3 - Chapter. AN - SCOPUS:79951603384. SN - 9780444519672. VL - 1-4. SP - 415. EP - 451. BT - Introduction to Glycoscience; Synthesis of Carbohydrates. PB - Elsevier. ER - ...
In molecular biology, glycoside hydrolase family 79 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. Glycoside hydrolase family 79 includes endo-beta-N-glucuronidase EC 3.2.1.31 and heparanase (CAZY GH_79). Heparan sulphate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulphate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena ...
In molecular biology, Glycoside hydrolase family 14 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. Glycoside hydrolase family 14 CAZY GH_14 comprises enzymes with only one known activity; beta-amylase (EC 3.2.1.2). A Glu residue has been proposed as a catalytic residue, but it is not known if it is the nucleophile or the proton donor. Beta-amylase is an enzyme that hydrolyzes 1,4-alpha-glucosidic linkages in starch-type polysaccharide substrates so as to remove successive maltose units from the non-reducing ends of ...
Glycoside Hydrolase Family 31, 978-620-0-10221-8, Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. In molecular biology, glycoside hydrolase family 31 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of |100 different families. This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
Weng, A, et al. (2015) Improved intracellular delivery of peptide- and lipid-nanoplexes by natural glycosides. J Control Release. 2015 May 28; 206:75-90. PM ID: ...
quercetin 3-O-alpha-L-rhamnopyranosyl-(1-2)-(beta-D-glucopyranosyl-(1-3)-alpha-L-(4-O-trans-p-coumaroylrhamnopyranosyl)-(1-6))-beta-D-galactopyranoside-7-O-alpha-L- ...
glycoside hydrolase family 2 protein; FUNCTIONS IN: carbohydrate binding, cation binding, beta-galactosidase activity, hydrolase activity, hydrolyzing O-glycosyl compounds, catalytic activity; INVOLVED IN: carbohydrate metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: male gametophyte, guard cell; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase family 2, immunoglobulin-like beta-sandwich (InterPro:IPR006102), Glycoside hydrolase, catalytic core (InterPro:IPR017853), Glycoside hydrolase, family 42, domain 5 (InterPro:IPR004199), Glycoside hydrolase family 2, TIM barrel (InterPro:IPR006103), Glycoside hydrolase, family 2 (InterPro:IPR006101), Glycoside hydrolase-type carbohydrate-binding (InterPro:IPR011013), Glycoside hydrolase-type carbohydrate-binding, subgroup (InterPro:IPR014718), Glycoside hydrolase family 2, carbohydrate-binding (InterPro:IPR006104), Glycoside hydrolase, subgroup, catalytic core (InterPro:IPR013781), Glycoside hydrolase, families 2 and 20, immunoglobulin-like ...
Rationale: Although phenylethanoid glycosides (PhGs) occur widely in plants, their characterisation by liquid chromatography/mass spectrometry (LC/MS) is l...
TY - JOUR. T1 - Triterpene glycosides from the tubers of Leontice smirnowii. AU - Tabatadze, N.. AU - Tabidze, B.. AU - Mshvildadze, V.. AU - Elias, R.. AU - Dekanosidze, G.. AU - Balansard, G.. AU - Kemertelidze, E.. PY - 2009/5/1. Y1 - 2009/5/1. UR - http://www.scopus.com/inward/record.url?scp=69249202266&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=69249202266&partnerID=8YFLogxK. U2 - 10.1007/s10600-009-9313-2. DO - 10.1007/s10600-009-9313-2. M3 - Article. AN - SCOPUS:69249202266. VL - 45. SP - 453. EP - 454. JO - Chemistry of Natural Compounds. JF - Chemistry of Natural Compounds. SN - 0009-3130. IS - 3. ER - ...
When a monosaccharide interacts with alcohol in the presence of acid catalyst called glycosides. When naming of glycosides, the (ose) suffix of the sugar name is replaced by (oside), and the alcohol group name is placed first. It is most common in acetals, glycoside formation involves the loss of an equivalent of water. The diether product is stable to base and alkaline oxidants such as Tollens reagent. Since acid-catalyzed aldolization is reversible, glycosides may be hydrolyzed back to their alcohol and sugar components by aqueous acid. ...
diabetes medication glycoside for sale - 52 - Manufacturer diabetes medication glycoside wholesalers & diabetes medication glycoside manufacturers from China manufacturers.
The methyl glycosides of N-acetyl-d-glucosamine (d-GlcNAc) and N-acetyl-d-galactosamine (d-GalNAc) have been used as model glycan analogs to study the effects of lithium cation binding on glycan structure in gas-phase experiments. Infrared multiple photon dissociation (IRMPD) spectra for the two Li+-complexed anomers of methyl-d-GlcNAc revealed a difference of 10 cm−1 between their respective carbonyl stretching band positions. A corresponding 11 cm−1 shift was observed for the two Li+-complexed anomers of methyl-d-GalNAc. Theoretical calculations indicate that the position of the methyl group (α and β, or axial and equatorial, respectively) on carbon 1 of the sugar and its close proximity to the carbonyl of the acetamido group on carbon 2 cause the average orientation of the carbonyl to change in order to minimize steric hindrance. This change in orientation is postulated to be the cause of the observed Cdouble bond; length as m-dashO stretching band shift. The calculations also predict ...
Improved pharmacokinetics and stability properties of catalase by chemical glycosidation with end-group activated dextran Journal of Applied Polymer Science Wiley 0021-8995 1097-4628 10.1002/APP.25019
Saccharide is also called carbohydrate, consisting of carbon (C), hydrogen (H) and oxygen (O) atoms, usually with the empirical formula Cm(H2O)n. The saccharides are divided into four chemical groups: monosaccharides, disaccharides, oligosaccharides, and polysaccharides. Carbohydrates perform numerous roles in living organisms. Polysaccharides serve for the storage of energy (e.g. starch and glycogen) and as structural components. The 5-carbon monosaccharide ribose is an important component of coenzymes (e.g. ATP, FAD and NAD) and the backbone of the genetic molecule known as RNA. The related deoxyribose is a component of DNA. Saccharides and their derivatives include many other important biomolecules that play key roles in the immune system, fertilization, preventing pathogenesis, blood clotting, and development.. A glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store ...
Saccharide is also called carbohydrate, consisting of carbon (C), hydrogen (H) and oxygen (O) atoms, usually with the empirical formula Cm(H2O)n. The saccharides are divided into four chemical groups: monosaccharides, disaccharides, oligosaccharides, and polysaccharides. Carbohydrates perform numerous roles in living organisms. Polysaccharides serve for the storage of energy (e.g. starch and glycogen) and as structural components. The 5-carbon monosaccharide ribose is an important component of coenzymes (e.g. ATP, FAD and NAD) and the backbone of the genetic molecule known as RNA. The related deoxyribose is a component of DNA. Saccharides and their derivatives include many other important biomolecules that play key roles in the immune system, fertilization, preventing pathogenesis, blood clotting, and development.. A glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store ...
Department of Chemistry, UBC Faculty of Science. Vancouver Campus. 2036 Main Mall. Vancouver, BC Canada V6T 1Z1. Tel: 604.822.3266. Fax: 604.822.2847. ...
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You are viewing an interactive 3D depiction of the molecule 2,4-dibromo-6-[3-(3-bromo-4-hydroxyphenyl)propanoyl]-3,5-dihydroxyphenyl beta-d-glucopyranoside (C21H21Br3O10) from the PQR.
ChemInform Abstract: Direct Chemical Synthesis of β-Mannopyranosides and Other Glycosides via Glycosyl Triflates.|span||/span| | D. CRICH; S. SUN | download | BookSC. Download books for free. Find books
The glycoside hydrolases of this family are lytic transglyosylases (also referred to as peptidoglycan lyases) of bacteriophage origin and they constitute family 4 of the classification scheme of Blackburn and Clarke [1]. Unfortunately, the origin of many of the hypothetical enzymes listed in GH104 is misleading because they are encoded within prophages which have been integrated into the chromosome of their bacterial host. In other cases, the phage enzyme has been acquired by pathogenicity islands on the bacterial chromosome. The prototype for this family is the enzyme from lambda phage. These enzymes cleave the β-1,4 linkage between N-acetylmuramoyl and N-acetylglucosaminyl residues in peptidoglycan (Figure 1). No other activities have been observed. ...
Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.
Synthesis and Characterization of Glycosides von Marco Brito-Arias und Buchbewertungen gibt es auf ReadRate.com. Bücher können hier direkt online erworben werden.
U.S. exports of Glycosides, natural or synthetic, and salts, ether decreased 25.84 percent from $7.95 million to $5.9 million through the first two months of 2020 when compared to the same period the previous year, according to WorldCity analysis of the latest U.S. Census Bureau data.
Cattle encephalon glycoside and ignotin injection improves cognitive impairment in APPswe/PS1dE9 mice used as multitarget anti-Alzheimers drug candidates. Neuropsychiatr Dis Treat. 2015; 11:537-48 ...
Disclosed is a process for purifying an impure anthracyclinone glycoside by selective adsorption of a slightly acidic aqueous solution of an impure glycoside on at least one resin and subsequent de-absorption of the purified glycoside by elution with acidic water or a mixture of water and a polar solvent.
Extra info for Carbohydrate chemistry Volume 34. Example text. 4~ HO OH 29 0 31 Me Amino-sugar glycosides. The torsionally constrained 2-azidoglycosyl donor 32 was used in the preparation of the a-linked glucosaminyl inositol (Scheme 3), and in the course of the same work alternative access to a-linked compounds of this type was obtained via a p-orthoester as indicated in Scheme 4? New work has been reported on the preparation of P-D-glucosaminides from the 1,2oxazoline hydrochloride 31 made from the p-glycosyl chloride. ~More specifically, compounds 33 were made from the corresponding ally1 glycosides by OBn - a-Linked glycoside (60%) N3 32 L-J Reagent: i, NBS Scheme 3 BnO&Ro- BnO j 0 Reagents: i, NIS; ii, Tf20, DMAP; iii, TMSN3, Bu4NF Scheme 4 OBn N3 20 Carbohydrate Chemistry initial epoxidations and nucleophilic epoxide ring openings,& and diosgenyl 2-amino-2-deoxy-f3-~-g~ucopyranosides with trichloroacetyl and tetrachlorophthaloyl N-protection were made from the corresponding 2-acetylated ...
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RUI: Functionalized bis (morindone-C, O-glycosides) for the molecular recognition of DNA in the major groove. Investigators in the field of molecular recognition study the non-covalent interactions between two (or more) molecules with the aim of understanding the driving forces behind these associations. With this information in hand, it is possible to develop a set of rules for the design of molecules (ligands) capable of specific binding interactions with other target molecules (receptors). DNA.... ...
28 UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1-,5)-beta-D-galactofuranosyl-(1-,4)-alpha-L-rhamnopyranosyl-(1-,3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = 28 UDP + [beta-D-galactofuranosyl-(1-,5)-beta-D-galactofuranosyl-(1-,6)]14-beta-D-galactofuranosyl-(1-,5)-beta-D-galactofuranosyl-(1-,4)-alpha-L-rhamnopyranosyl-(1-,3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis- ...
As part of Natural Medicine Week, accredited registered practitioners of the Australian Traditional-Medicine Society and partners are hosting a number of events throughout Australia. Find out if there is an event near to learn, hear or experience natural medicine for yourself.. Find Out More. ...
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TY - JOUR. T1 - Three new flavonol glycosides from Fissistigma pallens. AU - Nhiem, Nguyen Xuan. AU - Thinh, Ngo Sy. AU - Thu, Nguyen Thi Bich. AU - Anh, Luu The. AU - Ngoc, Tran Minh. AU - Tai, Bui Huu. AU - Yen, Pham Hai. AU - van Kiem, Phan. AU - van Minh, Chau. AU - Park, Seonju. AU - Kim, Seung Hyun. N1 - Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2015.79 and by National Research Foundation of (NRF) grant [NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea; NAFOSTED [104.01-2015.44]; NRF [2016R1A2B4006742].. PY - 2019. Y1 - 2019. N2 - Three new flavonol glycosides, fissflavosides A-C (1-3), together with six known flavonol glycosides, kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (4), kaempferol 3-O-α-L-rham-nopyranosyl-(1→6)-β-D-galactopyranoside (5), kaempferol ...
RATIONALENegative ESI-QIT-MS of several subtypes of flavonoid O-glycosides is known to produce deprotonated molecular ions which undergo homolytic fragmentation at the glycosidic bond upon collision-induced dissociation (CID). However, these subtypes have never been simultaneously compared under unified MS conditions.. METHODSThe (-)-ESI-MSn fragmentations of 69 flavonoid O-glycosides, involving eight subtypes, were analyzed using a quadrupole ion-trap mass spectrometer with collision energies varying from 18-44%. Factors influencing the homolytic glycosidic bond fragmentation, such as collision energy, hydroxylation of aglycone, and glycosylation pattern, were comprehensively studied.. RESULTSUnder the unified CID-QIT-MS2 conditions, the precursor deprotonated molecular ions [M-H](-) for 3-O-glycosyl, 3,7-di-O-glycosyl and 3,6,7-tri-O-glycosyl flavonols experienced homolytic fragmentation at the glycosidic bond and generated the radical aglycone ion [Y-0-H](-center dot). This gas-phase CID ...
The receptor for the wilt-inducing phytotoxin fusicoccin was purified to homogeneity from plasma membranes of Commelina communis as a complex with the radioligand [3H]9-nor-8-hydroxyfusicoccin. The preparation consisted of two polypeptides with apparent molecular masses of 30.5 kDa and 31.5 kDa an …
Examination of the bulbs of Lilium pumilum (Liliaceae) led to the isolation of four novel steroidal glycosides (1-4) with a 2,3,4-trisubstituted β-d-glucopyranosyl unit. In 1 and 3, the α-L-arabinopyranosyl moiety is linked to C-3 of the inner trisubstituted β-D-glucopyranosyl group and is present as an usual 4C1 conformation. In contrast, in 2 and 4, the α-L-arabinopyranosyl moiety, which is attached to C-4 of the inner trisubstituted β-D-glucopyranosyl group, is present as a 1C4 conformation. The structures of the new steroidal glycosides were determined based on the results of spectroscopic analyses, including two-dimensional (2D) NMR data and hydrolysis.
TY - JOUR. T1 - Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum. AU - Rateb, Mostafa E. AU - Hassan, Hossam M. AU - Arafa, El-Shaimaa A. AU - Jaspars, Marcel. AU - Ebel, Rainer. AU - Rateb, Mostafa Ezzat Mohamed. PY - 2014/4. Y1 - 2014/4. N2 - Bioassay and NMR-guided fractionation of the methanolic extract of Rhododendron decorum leaves resulted in the isolation of two new flavonoid glycosides, 5,7-dihydroxy-6,8-dimethyldihydroflavanone-7-O-alpha-L-arabinopyranosyl(1--,6)-beta-D-glucopyranoside (decoroside A, 1) and its 3-hydroxy congener (decoroside B, 2), along with five known compounds myricitrin (3), afzelin (4), (-)-epicatechin (5), (+)-catechin (6), and ampeloptin (7). The structures of the isolated compounds were elucidated by extensive interpretation of their spectral data. Biological evaluation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed promising cytotoxic activities of these compounds against ...
Abstract: Premise of the study: Microsatellite primers were developed for the common milkweed, Asclepias syriaca, to assist in genet identification and the analysis of spatial genetic structure. • Methods and Results: Using an enrichment cloning protocol, eight microsatellite loci were isolated and characterized in a North American population of A. syriaca. The primers amplified di- and tri-nucleotide repeats with 4-13 alleles per locus. • Conclusions: The primers will be useful for studies of clonality and gene flow in natural populations. Abstract: Chapter 3 Spatial genetic structure (SGS) is largely determined by the reproductive strategies of species. Many plant species, including Asclepias syriaca, the common milkweed, reproduce both sexually and asexually and there can be great variation in SGS among species that reproduce by both methods. SGS was assessed within an old field population of A. syriaca in northern Michigan. Strong SGS was detected to 38 m when multiple identical ...
Absolute most potent extract of Cistanche available. Known for immune action and reduction of the markers of aging. 60% Phenylethanoid Glycosides, 22% Echinacoside, 8% Acetoside
Glycosides are classified based on the following: 1) Chemical nature of aglycone part 2)Therapeutic activity of aglycone part. 3)Type of linkage between glycone and aglycone part. REF:PHARMACOGNOSY:NEERALI PRAKASHAN PUBLICATIONS. 34 edition, page-167 ...
The aim of this study was to identify and elucidate the vasorelaxant activity of echinacoside, a phenylethanoid glycoside isolated from the medicinal herb Cistanche tubulosa, and its possible underlying mechanism on isolated rat thoracic aortic rings pre-contracted with phenylephrine (PE, 1 mu M) and KCI (60 mM). Echinacoside (30-300 mu M) exhibited an acute relaxation in endothelium-intact rings in a concentration-dependent manner, while this relaxation was significantly inhibited in endothelium-denuded condition and in the presence of the endothelial nitric oxide synthase (eNOS) inhibitor, N-w-nitro-L-arginine methyl ester (L-NNA, 100 mu M), an unselective Soluble guanylate cyclase blocker, methylene blue (10 mu M), the selective sGC inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 1 mu M); in addition, atropine (1 mu M), a selective muscarinic receptor antagonist, partially affected the relaxation. However, the cyclooxygenase inhibitor indomethacin (5 mu M) had no influence on the ...
AbstractActein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida (Chinese herb shengma) which could inhibit the growth of breast cancer cells. Nevertheless, the effect of actein on angiogenesis, which is an essential step for tumor growth and metastasis, has never been reported. Hence, this study aimed to investigate the in vitro and in vivo effects of actein on angiogenesis using human microvascular endothelial cells (HMEC-1), matrigel plug and tumor-bearing mouse models. Our results showed that actein significantly inhibited the proliferation, reduced the migration and motility of endothelial cells, and it could suppress the protein expressions of VEGFR1, pJNK and pERK, suggesting that JNK/ERK pathways were involved. In vivo results showed that oral administration of actein at 10 mg/kg for 7 days inhibited blood vessel formation in the growth factor-containing matrigel plugs. Oral actein treatments (10-15 mg/kg) for 28 days resulted in decreasing mouse 4T1 breast ...
Pharmacological Investigations of Phenylethanoid Glycosides in Blue Light and N-Retinylidene-N-Retinylethanolamine Induced Retinal Degeneration and Their Protective Effects in ...
Triterpene Glycosides Black Cohosh Extract Manufacturers, Factory, Suppliers From China, We are looking forward to building positive and beneficial links with the companies around the world. We warmly welcome you to contact us to begin discussions on how we can bring this into being.
Great spangled fritillary (Speyeria cybele) on common milkweed (Asclepias syriaca). Wild River State Park, MN, USA.. WildRiverStatePark227Asclepias syriacaFaunaFloraMinnesotaSpeyeria cybeleUSAWild River State Parkbutterflycommon milkweedgreat spangled fritillaryinsectwildlife. From Speyeria cybele - Great spangled fritillary (USA) ...
The present study was aimed to evaluate the in vivo radioprotective efficacy of quercetin-3-O-rutinoside (PMC-1), the key bioactive constituent flavonoid glycoside isolated from the whole plant of Pilea microphylla was evaluated. In vivo survival studies established the optimum effective dose of PMC-1 at 25 mg/kg/i.p. At the optimum dose, PMC-1 prevented the depletion of endogenous antioxidants in the liver of irradiated mice. In vivo protection towards gastrointestinal tract and haematopoietic system was confirmed by the restoration of radiation-induced reduction in villi height, number of crypt cells and spleen index. PMC-1 also attenuated the radiation-induced apoptosis in spleenocytes significantly. Single cell gel electrophoresis of peripheral blood leukocytes showed inhibition of radiationinduced DNA damage by PMC-1. PMC-1 pretreatment significantly reversed the changes by increasing pro-survival (ERK) and decreasing pro-apoptotic (BAX) gene expressions compared to radiation control. Thus, ...
Chemical investigation of Maesa lanceolata leaves aqueous MeOH extract has led to the isolation of eight new triterpene glycosides identified as 16-oxo-28-hydroxyolean-12-ene 3- O - β -glucopyranosyl-(1 → 6)- β -glucopyranoside 1 , 16 α , 28-dihydroxyolean-12-ene 3 - O - β -[(6- O -galloylglucopyranosyl-(1 → 2)][ β -glucopyranosyl-(1 → 6)]- β -glucopyranoside 2, 16 α , 22 α , 28-trihydroxyolean-12-ene 3- O -[ β -glucopyranosyl-(1 → 2)] [ α -rhamnopyranosyl- (1 → 6]- β -glucopyranoside 3 , 22 α -acetyl-16 α -hydroxyolean-12-en-28-al 3- O -[ α -rhamnopyranosyl- (1  6)- β -glucopyranosyl-(1  3)] [ β -glucopyranosyl-(1  2)]- β -arabinopyranoside 4 , 22 α -acetyl-16 α ,21 β -dihydroxyoleanane-13 β :28-olide 3- O -[ β -glucopyranosyl-(1 → 6)] [6- O -coumaroylglucopyranosyl-(1 → 2)]- β -glucopyranoside 5 , 16 α ,22 α -diacetyl-21 β - angeloyloleanane-13 β :28-olide 3 β - O -[ β -glucopyranosyl-(1 → 2)][ ...
Glycoconjugate antigens are prepared by preparing a hapten glycoside, especially an alpha glycoside prepared by the Fischer method, with an olefinic aglycon moiety, especially one having a non-terminal double bond, ozonolyzing the hapten glycoside with an olefinic aglycon moiety having a non-terminal double bond to form a hapten-glycoside derivative, preferably without producing Germaldehyde as a by-product, removing by-products of ozonolysis, and conjugating the hapten-glycoside derivative to a carrier.
https://www.reporthive.com/request_customization/2574396. Table of Contents. Report Overview:It includes major players of the global Alkyl Glycoside Market covered in the research study, research scope, and Market segments by type, market segments by application, years considered for the research study, and objectives of the report.. Global Growth Trends:This section focuses on industry trends where market drivers and top market trends are shed light upon. It also provides growth rates of key producers operating in the global Alkyl Glycoside Market. Furthermore, it offers production and capacity analysis where marketing pricing trends, capacity, production, and production value of the global Alkyl Glycoside Market are discussed.. Market Share by Manufacturers:Here, the report provides details about revenue by manufacturers, production and capacity by manufacturers, price by manufacturers, expansion plans, mergers and acquisitions, and products, market entry dates, distribution, and market areas ...
The known flavonoid chrysin-7-O-(β-D-glycopyranoside) (chrysin glucoside,1) as a major fraction and a new glycoside flavone, chrysin-7-O-β-D-[(6
We have a new research publication out this week in collaboration with the Weinert lab at Emory. It is available via open access HERE.. Fontaine, B.M., K. Nelson, J.T. Lyles, P.B. Jariwala, J. M. Garcia-Rodriguez, C.L. Quave, E.E. Weinert. (2017) Identification of Ellagic Acid Rhamnoside as a Bioactive Component of a Complex Botanical Extract. Frontiers in Microbiology 8:496 doi: 10.3389/fmicb.2017.00496. Abstract. Staphylococcus aureus is a leading cause of hospital-acquired infections. It is listed among the top serious threats to human health in the USA, due in large part to rising rates of resistance. Many S. aureus infections are recalcitrant to antibiotic therapy due to their ability to form a biofilm, which acts not only as a physical barrier to antibiotics and the immune system, but results in differences in metabolism that further restricts antibiotic efficacy. Development of a modular strategy to synthesize a library of phenolic glycosides allowed for bioactivity testing and ...
TY - JOUR. T1 - Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade. AU - Shen, Shing Chuan. AU - Chen, Yen Chou. AU - Hsu, Feng-Lin. AU - Lee, Woan Rouh. PY - 2003/8/1. Y1 - 2003/8/1. N2 - Flavonoids were demonstrated to possess several biological effects including antitumor, antioxidant, and anti-inflammatory activities in our previous studies. However, the effect of glycosylation on their biological functions is still undefined. In the present study, the apoptosis-inducing activities of three structure-related flavonoids including aglycone quercetin (QUE), and glycone rutin (RUT; QUE-3-O-rutinoside), and glycone quercitrin (QUI; QUE-3-O-rhamnoside) were studied. Both RUT and QUI are QUE glycosides, and possess rutinose and rhamnose at the C3 position of QUE, respectively. Results of the MTT assay showed that QUE, but not RUT and QUI, exhibits significant cytotoxic effect on HL-60 cells, ...
This family of glycoside hydrolases exclusively contains phosphorylases that cleave β-glycosidic bonds. The substrate specificities found in GH94 are: cellobiose (Glc-β1,4-Glc) phosphorylase (EC 2.4.1.20), cellodextrin ((Glc-β1,4-)n-1Glc; n ≥ 3) phosphorylase (EC 2.4.1.49), and N,N-diacetyl chitobiose (GlcNAc-β1,4-GlcNAc) phosphorylase. Moreover, a phosphorylase domain belonging to this family is found in cyclic β-1,2-glucan synthase, a modular protein that also contains a glycosyltransferase domain from Glycosyltransferase Family 84 [1]. The GH94 domain is thought to phosphorolyze protein-bound β-1,2-glucans synthesized from UDP-glucose by the GT84 domain. GH94 enzymes were initially classified in Glycosyltransferase Family 36 because none of them show hydrolytic activity. However because of the evolutionary, structural and mechanistic relatedness with clan GH-L glycoside hydrolases, the family was re-assigned to family GH94 [2]. ...
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TY - JOUR. T1 - Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach.. AU - Sumida, Tomomi. AU - Stubbs, Keith A.. AU - Ito, Makoto. AU - Yokoyama, Shigeyuki. PY - 2012/4/7. Y1 - 2012/4/7. N2 - One useful methodology that has been used to give insight into how chemically synthesized inhibitors bind to enzymes and the reasons underlying their potency is crystallographic studies of inhibitor-enzyme complexes. Presented here is the X-ray structural analysis of a representative family 20 exo-β-N-acetylhexosaminidase in complex with various known classes of inhibitor of these types of enzymes, which highlights how different inhibitor classes can inhibit the same enzyme. This study will aid in the future development of inhibitors of not only exo-β-N-acetylhexosaminidases but also other types of glycoside hydrolases.. AB - One useful methodology that has been used to give insight into how chemically synthesized inhibitors bind ...
Plant-derived cardiac glycosides particularly digoxin can be used for the treating congestive heart failure along with other cardiac disorders (1).05) Figure 1: Cardiac glycoside items of detoxified TSM...
Glycosides are compounds which contain two parts: a sugar component which is in its cyclic (ring) form, and another component attached to the sugar at the number 1 (or glycosidic carbon). Some of these companion molecules can also be sugars, so sucrose, being a 2-sugar molecule (disaccharide) made of one glucose unit and one fructose unit attached through the appropriate carbon, is an example of one of these types of glycosides. The glycosides which appear to influence beer flavor are found in hops and have aromatic compounds bonded to the carbohydrates. In their combined state, the glycosides have no flavor; no sweetness and no aroma. However, once this glycosidic bond is broken the aromatic compound is free to volatilize into the headspace of the beer and ultimately into your nose ...
Some glycoside hydrolases have broad specificity for hydrolysis of glycosidic bonds, potentially increasing their functional utility and flexibility in physiological and industrial applications. To deepen the understanding of the structural and evolutionary driving forces underlying specificity patterns in glycoside hydrolase family 5, we quantitatively screened the activity of the catalytic core domains from subfamily 4 (GH5_4) and closely related enzymes on four substrates: lichenan, xylan, mannan, and xyloglucan. Phylogenetic analysis revealed that GH5_4 consists of three major clades, and one of these clades, referred to here as clade 3, displayed average specific activities of 4.2 and 1.2U/mg on lichenan and xylan, approximately 1 order of magnitude larger than the average for active enzymes in clades 1 and 2. Enzymes in clade 3 also more consistently met assay detection thresholds for reaction with all four substrates. We also identified a subfamily-wide positive correlation between ...
Caldicellulosiruptor glycoside hydrolase inventory.As mentioned above, only two (C. bescii and C. saccharolyticus) of the nine described Caldicellulosiruptor species currently have publically available genome sequences (29, 51). Due to renewed interest in biomass-degrading microbes, five additional genome sequencing projects are under way, three of which are finished (for C. hydrothermalis, C. kronotsyensis, and C. owensensis), to help pinpoint what makes some species more cellulolytic than others in the genus. Draft and finished versions of these genome sequences were examined for GH family diversity.. Previous studies looking into Caldicellulosiruptor diversity have identified glycoside hydrolases, mostly cellulases and xylanases, produced by selected species (4, 19). Here, the biomass deconstruction-related GH inventory, inferred from each draft and finished genome sequence, was examined to provide insights into the observed differential responses to microcrystalline cellulose. Based on the ...
Publication Details (including relevant citation information): Lavandulifolioside: A New Phenylpropanoid Glycoside from Stachys lavandulifolia
Calendula Flowers | contains a variety of active natural compounds, such as flavonol glycosides, triterpene oligoglycosides, and soothing ...
Robb, CS, Mystkowska, AA and Hehemann, JH (2017) Crystal structure of a marine glycoside hydrolase family 99-related protein lacking catalytic machinery. Protein Science, 26(12). 2445-2450. doi:10.1002/pro.3291 ...
As a rule, about 1% of genes in a given genome encode glycoside hydrolases and their homologues. On the basis of sequence similarity they have been grouped into more than ninety GH families during the last 15 years. The GH97 family has been established very recently and initially included only 18 bacterial proteins. However, the evolutionary relationship of the genes encoding proteins of this family remains unclear, as well as their distribution among main groups of the living organisms. The extensive search of the current databases allowed us to double the number of GH97 family proteins. Five subfamilies were distinguished on the basis of pairwise sequence comparison and phylogenetic analysis. Iterative sequence analysis revealed the relationship of the GH97 family with the GH27, GH31, and GH36 families of glycosidases, which belong to the α-galactosidase superfamily, as well as a more distant relationship with some other glycosidase families (GH13 and GH20). The results of this study show an
INDICATIONS. Hoodia is a natural appetite suppressant that helps you reduce your interest in food and makes you feel full faster and longer.. INSTRUCTIONS. The use of Hoodia in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/ health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.. If you miss a dose of this medicine and you are using it regularly, take it as soon as possible. If you do not remember until later, skip the missed dose and go back to your regular dosing schedule ...
A comparative discussion of the signals in the13C NMR spectra of acetylated methyl α- and β-D-xylopyranosides, α- and β-D-glucopyranosi
Healthy circulation formula. Natural extract of ginkgo biloba herbs with a minimum of 24% glycosides and 6% ginkgoglides. Helps maintain normal brain and nervous system function.
I found this link trying to explain it: Why pyranosides do not mutarotate? however, I dont understand a step of the reasoning.. Why is it that acetalisation needs a stronger acid than for hemi-acetalisation? I was wondering why cant the mechanism be similar to the the one for the mutarotation of glucose as shown below: ...
The treatment of cardiac failure is complicated by the difficulty in determining the optimal therapeutic response and undesirable side-effects. The side-effects of cardiac glycosides can be...
High-level prescribing trends for Cardiac glycosides (BNF section 2.1.1) across all GP practices in NHS England for the last five years. You can explore prescribing trends for this section by CCG, or learn more about this site.. View all matching dm+d items.. ...
hoodia oxypregnane, steroidal, glycoside, Bushmans hat,Xhoba, Hoodia has received publicity in recent times for its natural appetite suppressant properties..
If the shape of the health-care team in this syndrome. [note exercises to improve his or her own beliefs about an area of the source of ie is social security. Or do you often have indigestion, if others are discussed extensively in other parts of the dark or black. Repeat doses of 190-280 mg. Patients may also need to be available in his or her problem. 57 the caregiver in identifying environmental stimuli (light, sounds, and disorientation. In all situations there is raised blood pressure, an effect on the system fights back and you may need only to the possibility of recurrence and for the client will spend [number] minutes with the client, meeting needs in an acid and oxalate raphides oxalates strychnine and brucine carboxylic acid none glycosides: Other cyanogenic glycoside apple western choke cherry wild black cherry elderberry failure (chap. Dilutional therapy should be discontinued prior to teaching sessions. Exaggerated startle response 15. It may occur and can bypass the blockage. ...
Treatment of peracetylated alkyl and aryl 1,2-trans-glycosides with iodine in the presence of HMDS has been found to result in the anomerization leading to the formation of the respective 1,2-cis-glycosides. In the case of alkyl glycosides with aglyc
An alkenyl glycoside is prepared by reacting a metathesis-derived unsaturated fatty alcohol containing 10 to 30 carbon atoms with either (1) a reducible monosaccharide or composition hydrolyzable to
Glycosides can be linked by an O- (an O-glycoside), N- (a glycosylamine), S-(a thioglycoside), or C- (a C-glycoside) glycosidic ... glycosides are classified as α-glycosides or β-glycosides. Some enzymes such as α-amylase can only hydrolyze α-linkages; others ... Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. ... The two primary glycosides, stevioside and rebaudioside A, are used as natural sweeteners in many countries. These glycosides ...
"Cardiac Glycosides". www.people.vcu.edu. Retrieved 2017-05-25. Cheeke PR (1989-07-31). Toxicants of Plant Origin: Glycosides. ... The general structure of a cardiac glycoside consists of a steroid molecule attached to a sugar (glycoside) and an R group. The ... as done by cardiac glycosides. Nevertheless, due to questions of toxicity and dosage, cardiac glycosides have been replaced ... Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of ...
P57 is an oxypregnane steroidal glycoside isolated from the African cactiform Hoodia gordonii. P57 is hypothesized to be the ... studies of the anorectic mechanism of a plant steroidal glycoside". Brain Research. 1020 (1-2): 1-11. doi:10.1016/j.brainres. ...
... , also known as sennoside or senna, is a medication used to treat constipation and empty the large intestine ... Common side effects of senna glycoside include abdominal cramps. It is not recommended for long-term use, as it may result in ... Senna glycosides can increase digoxin toxicity in patients taking digoxin by reducing serum potassium levels, thereby enhancing ... They are anthraquinone derivatives and dimeric glycosides. Senna is an over-the-counter medication available in multiple ...
Glycoside Stevia Sugar substitute Brandle, J. E.; Telmer, P. G. (2007). "Steviol glycoside biosynthesis" (PDF). Phytochemistry ... Steviol glycosides are the chemical compounds responsible for the sweet taste of the leaves of the South American plant Stevia ... A commercial steviol glycoside mixture extracted from the plant was found to have about 80% stevioside, 8% rebaudioside A, and ... Synthesis of steviol glycoside begins with isoprene units created via the DXP or MEP pathway. Two molecules derived from ...
... s are classified into EC 3.2.1 as enzymes catalyzing the hydrolysis of O- or S-glycosides. Glycoside ... Mutant glycoside hydrolases termed glycosynthases have been developed that can achieve the synthesis of glycosides in high ... Thioglycoligases catalyze the condensation of activated glycosides and various thiol-containing acceptors. Various glycoside ... Mucopolysaccharidoses Glucosidase Lysozyme Glycosyltransferase List of glycoside hydrolase families Clans of glycoside ...
In molecular biology, glycoside hydrolase family 70 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... "Glycoside Hydrolase Family 70". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 36 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 36 can be subdivided into 11 families, GH36A to GH36K. Henrissat B, Callebaut I, Mornon JP, Fabrega ... Glycoside hydrolase family 36 also includes enzymes with α-N-acetylgalactosaminidase EC 3.2.1.49 and stachyose synthase EC 2.4. ... Glycoside hydrolase family 36 together with family 31 and family 27 alpha-galactosidases form the glycosyl hydrolase clan GH-D ...
In molecular biology, glycoside hydrolase family 108 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 108 CAZY GH_108 includes enzymes with lysozyme (N-acetylmuramidase) EC 3.2.1.17 activity. A glutamic ... "Glycoside Hydrolase Family 108". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 35 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 35 CAZY GH_35 comprises enzymes with only one known activity; beta-galactosidase (EC 3.2.1.23). ... "Glycoside Hydrolase Family 35". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
... is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a widespread group of ... Glycoside hydrolase family 1 CAZY GH_1 comprises enzymes with a number of known activities; beta-glucosidase (EC 3.2.1.21); ... "Glycoside Hydrolase Family 1". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 63 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... "Glycoside Hydrolase Family 63". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 100 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 100 CAZY GH_100 includes enzymes with invertase activity EC 3.2.1.26. Henrissat B, Callebaut I, ... "Glycoside Hydrolase Family 100". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, Glycoside hydrolase family 11 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 11 CAZY GH_11 comprises enzymes with only one known activity, xylanase (EC 3.2.1.8). These enzymes ... "Glycoside Hydrolase Family 11". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 39 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 39 CAZY GH_39 comprises enzymes with several known activities; alpha-L-iduronidase (EC 3.2.1.76); ... "Glycoside Hydrolase Family 39". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 66 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 66 CAZY GH_66 includes enzymes with cycloisomaltooligosaccharide glucanotransferase EC 2.4.1.248 and ... "Glycoside Hydrolase Family 66". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 24 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 24 CAZY GH_24 comprises enzymes with only one known activity; lysozyme (EC 3.2.1.17). This family ... "Glycoside Hydrolase Family 24". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 77 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... "Glycoside Hydrolase Family 77". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 65 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... "Glycoside Hydrolase Family 65". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, Glycoside hydrolase family 18 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... "Glycoside Hydrolase Family 18". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 33 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... "Glycoside Hydrolase Family 33". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 7 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 7 CAZY GH_7 comprises enzymes with several known activities including endoglucanase (EC 3.2.1.4) and ... "Glycoside Hydrolase Family 7". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 92 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 92 includes enzymes with mannosyl-oligosaccharide α-1,2-mannosidase EC 3.2.1.113, mannosyl- ... "Glycoside Hydrolase Family 92". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 71 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... "Glycoside Hydrolase Family 71". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, Glycoside hydrolase family 10 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 10 CAZY GH_10 comprises enzymes with a number of known activities; xylanase (EC 3.2.1.8); endo-1,3- ... "Glycoside Hydrolase Family 10". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 78 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 78 CAZY GH_78 includes enzymes with α-L-rhamnosidase EC 3.2.1.40 activity. This family includes ... For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in ... "Glycoside Hydrolase Family 78". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ...
In molecular biology, glycoside hydrolase family 44 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 44 CAZY GH_44, formerly known as cellulase family J, includes enzymes with endoglucanase EC 3.2.1.4 ... "Glycoside Hydrolase Family 44". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, Glycoside hydrolase family 17 is a family of glycoside hydrolases. It folds into a TIM barrel. Glycoside ... y[ _]9 Glycoside hydrolase family 17 CAZY GH_17 comprises enzymes with several known activities; endo-1,3-beta-glucosidase (EC ... "Glycoside Hydrolase Family 17". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 73 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 73 CAZY GH_73 includes peptidoglycan hydrolases with endo-β-N-acetylglucosaminidase specificity. ... "Glycoside Hydrolase Family 73". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
In molecular biology, glycoside hydrolase family 37 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a ... Glycoside hydrolase family 37 CAZY GH_37 comprises enzymes with only one known activity; trehalase (EC 3.2.1.28). Trehalase is ... "Glycoside Hydrolase Family 3". CAZypedia.org. Retrieved 2018-03-06. CAZypedia Consortium (December 2018). "Ten years of ... A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different ...
Cardiac glycosides are medicines for treating heart failure and certain irregular heartbeats. They are one of several classes ... The medicine digoxin contains cardiac glycosides.. Besides the foxglove plant, cardiac glycosides also occur naturally in ... Cardiac glycoside overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be ... Cardiac glycoside is a chemical that has effects on the heart, stomach, intestines, and nervous system. It is the active ...
Cardiac glycosides. Class Summary. Decrease AV nodal conduction, primarily by increasing vagal tone. ... Cardiac glycoside with direct inotropic effects in addition to indirect effects on cardiovascular system. Acts directly on ...
Bioavailability of cyanidin glycosides from natural chokeberry (Aronia melanocarpa) juice with dietary-relevant dose of ...
Cardiac glycosides. Class Summary. These drugs slow AV nodal conduction primarily by increasing vagal tone. They are used ...
Cyanogenic Glycosides in Plant Foods by Bolarinwa Islamiyat Folashade, Orfila Caroline from Waterstones today! Click and ... Natural Plant Toxins - Cyanogenic Glycosides in Plant Foods (Paperback). Bolarinwa Islamiyat Folashade (author), Orfila ...
Cohesin module from Clostridium perfringens ATCC13124 family 33 glycoside hydrolase. ... Cohesin module from Clostridium perfringens ATCC13124 family 33 glycoside hydrolase.. *PDB DOI: 10.2210/pdb2VO8/pdb ...
Aim: To test whether the antineoplastic, antipathogenic plant derived secondary metabolites, solasodine glycosides, can treat ... containing solasodine glycosides, for his psoriasis. Result: Topical applications of PsorendBEC twice daily resulted in ... The same solasodine glycosides, but in a different topical cream formulation, CuradermBEC5, is effective against a wide variety ... Solasodine Glycosides from the Eggplant in a Topical Cream PsorendBEC Are Effective against Psoriasis () ...
The isolation of four novel acylated flavonoid glycosides from the roots of Saussurea lappa and their identification using a ... Acylated Flavone Glycosides from the Roots of Saussurea lappa and Their Antifungal Activity by Kolisetty Sambasiva Rao ... "Acylated Flavone Glycosides from the Roots of Saussurea lappa and Their Antifungal Activity" Molecules 12, no. 3: 328-344. ... "Acylated Flavone Glycosides from the Roots of Saussurea lappa and Their Antifungal Activity" Molecules 12, no. 3: 328-344. ...
Here, kasugamycin was discovered to be a competitive inhibitor of glycoside hydrolase family 18 (GH18) chitinases from three ... Here, kasugamycin was discovered to be a competitive inhibitor of glycoside hydrolase family 18 (GH18) chitinases from three ... Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases. Huitang Qi1†, Xi Jiang3†, Yi Ding1 ... The glycoside hydrolase family 18 (GH18) chitinases (EC 3.2.1.14) are key enzymes that biodegrade chitin, which is the most ...
Notice of Modification to the List of Permitted Sweeteners to Enable the Use of Steviol Glycosides from Stevia rebaudiana ... If you wish to contact the Food Directorate electronically, please use the words "Steviol glycosides" in the subject line of ... Notice of Modification to the List of Permitted Sweeteners to Enable the Use of Steviol Glycosides from Stevia rebaudiana ... Canada had previously permitted steviol glycosides from the stevia plant to comprise one or more of ten named steviol ...
A concentration dependent inhibition of the cellular uptake of both cardiac glycosides by quinine and quinidine was found, ... A multispecific uptake system for taurocholate, cardiac glycosides and cationic drugs in the liver.. *H. Steen, M. Merema, D. ... Interactions of cationic drugs and cardiac glycosides at the hepatic uptake level: studies in the ratin vivo, isolated perfused ... Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat ...
A covenient entry to 2-C-methylene glycosides C. Booma and K. K. Balasubramanian, J. Chem. Soc., Chem. Commun., 1993, 1394 DOI ... Syntheis of tri-O-benzyl-2-C-acetoxymethylglycals and subsequent Ferrier rearangement to give 2-C-methylene glycosides is ...
Studies revealed no adverse effects of steviol glycosides whenever taken at amounts of approximately 4 mg per day. In December ... Scientific information on steviol glycosides, including rebaudioside A (used in rebiana) and concluded that theyre safe ...
EverSweet contains Rebaudioside M and Rebaudioside D, two of the sweeter-tasting steviol glycosides. EverSweet gives food and ... EverSweet contains Rebaudioside M and Rebaudioside D, two of the sweeter-tasting steviol glycosides. EverSweet gives food and ... Home » Inside the new fermentation facility that produces steviol glycoside ingredients. Inside the new fermentation facility ...
... and serum cardiac glycoside concentrations on presentation to hospital ... and serum cardiac glycoside concentrations on presentation to hospital ...
Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK. / Xu, Ya ming; Smith, Jeffrey ... Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK. In: Bioorganic and Medicinal ... Xu, Y. M., Smith, J. A., Lannigan, D. A., & Hecht, S. M. (2006). Three acetylated flavonol glycosides from Forsteronia refracta ... Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK. Bioorganic and Medicinal ...
Research, Technology, Methods , chemical substances , biochemical compounds , carbohydrates , glycosides. Fields of Study , ...
XESTOVANIN-A AND SECOXESTOVANIN-A, TRITERPENOID GLYCOSIDES WITH NEW CARBON SKELETONS FROM THE SPONGE XESTOSPONGIA-VANILLA. ... XESTOVANIN-A AND SECOXESTOVANIN-A, TRITERPENOID GLYCOSIDES WITH NEW CARBON SKELETONS FROM THE SPONGE XESTOSPONGIA-VANILLA. ... XESTOVANIN-A AND SECOXESTOVANIN-A, TRITERPENOID GLYCOSIDES WITH NEW CARBON SKELETONS FROM THE SPONGE XESTOSPONGIA-VANILLA ...
Comparing glycoside hydrolase profiles of R. bieti with those of other animal revealed that the R. bieti microbiome was most ... Metagenomic and functional analysis demonstrated that R. bieti possesses a broad diversity of bacteria and numerous glycoside ... From: Metagenomic analysis of the Rhinopithecus bieti fecal microbiome reveals a broad diversity of bacterial and glycoside ...
Evolution of a major virion protein of the giant pandoraviruses from an inactivated bacterial glycoside hydrolase. ... evolved from an inactivated derivative of a bacterial glycoside hydrolase of the GH16 family. The ancestral form of MVP2 was ...
... has a modular structure consisting of a glycoside hydrolase family 10 catalytic domain and CBM1 at the C-terminus separated by ... From: Contribution of a family 1 carbohydrate-binding module in thermostable glycoside hydrolase 10 xylanase from Talaromyces ...
Steviol glycosides (SGs) are extracted from Stevia leaves for use as a natural sweetener. Among SGs, stevioside is most ... Kim, M.J., Zheng, J., Liao, M.H., Jang, I.-C. (2019). Overexpression of SrUGT76G1 in Stevia alters major steviol glycosides ... Overexpression of SrUGT76G1 in Stevia alters major steviol glycosides composition towards improved quality. ...
Effect of sun exposure on carotenoids and C13-norisoprenoid glycosides in Syrah berries (Vitis vinifera L.). Sciences des ... Effet de lensoleillement sur les teneurs en caroténoïdes et en glycosides de C13-norisoprénoïdes dans les baies de Syrah ( ... Effect of sun exposure on carotenoids and C13-norisoprenoid glycosides in Syrah berries (Vitis vinifera L.) ...
Glycoside hydrolases (GHs) are the enzymes that catalyze the cleavage of glycosidic bonds, which link carbohydrate units to ...
New Acylated Flavonol Glycosides and a Phenolic Profile of Pritzelago alpina, a Forgotten Edible Alpine Plant ... New Acylated Flavonol Glycosides and a Phenolic Profile of Pritzelago alpina, a Forgotten Edible Alpine Plant. Chemistry & ... Thirteen acylated flavonoid glycosides, 1-13, including eleven new congeners, 3-13, were isolated from the aerial parts of ... The new compounds were shown to be kaempferol and quercetin glycosides acylated for most of them by a branched short chain ...
Glycoside Hydrolase Family 57. From CAZypedia. Revision as of 05:08, 13 January 2010 by Stefan Janecek. (talk , contribs) (→‎ ... S Amylolytic families of glycoside hydrolases: focus on the family GH-57. Biologia 2005; 60(Suppl. 16) 177-84. ... R, and Janecek S. Relationships between SLH motifs from different glycoside hydrolase families. Biologia 60(Suppl. 16) 115-21. ... Zona R, Chang-Pi-Hin F, ODonohue MJ, and Janecek S. (2004). Bioinformatics of the glycoside hydrolase family 57 and ...
Dive into the research topics of Synthetic studies on natural pterin glycosides. Together they form a unique fingerprint. ...
The large Glycoside Hydrolase family 5 (GH5) groups together a wide range of enzymes acting on β-linked oligo- and ... Table 1 Newly defined subfamilies within glycoside hydrolase family GH5 Full size table. ... The large Glycoside Hydrolase family 5 (GH5) groups together a wide range of enzymes acting on β-linked oligo- and ... The module types and other protein segments present are: GHx_y - glycoside hydrolase family x subfamily y (pink); CEx - ...
  • Health Canada's Food Directorate received a food additive submission requesting that the permitted steviol glycosides content of this sweetener be expanded to include all the steviol glycosides in the Stevia rebaudiana Bertoni plant (stevia plant). (canada.ca)
  • As no safety concerns were raised through Health Canada's assessment the Department has enabled the expanded use of the food additive steviol glycosides to comprise all the steviol glycosides in the Stevia rebaudiana Bertoni plant described in the information document below by updating the List of Permitted Sweeteners , effective August 30, 2017 . (canada.ca)
  • Health Canada's Food Directorate is committed to reviewing any new scientific information on the safety in use of any food additive, including steviol glycosides. (canada.ca)
  • If you wish to contact the Food Directorate electronically, please use the words " Steviol glycosides " in the subject line of your e-mail. (canada.ca)
  • Studies revealed no adverse effects of steviol glycosides whenever taken at amounts of approximately 4 mg per day. (silt3.com)
  • Prior to this, stevia-based ingredients were only permitted to be used as a dietary health supplement into the U.S. Scientific information on steviol glycosides, including rebaudioside A (used in rebiana) and concluded that they're safe because of their desired usage - to sweeten foods and beverages and established a permanent appropriate day-to-day Intake (ADI) degree. (silt3.com)
  • EverSweet contains Rebaudioside M and Rebaudioside D, two of the sweeter-tasting steviol glycosides. (foodbusinessnews.net)
  • Steviol Glycosides Labeling - What's new? (foodlawlatest.com)
  • A new enzymatic process for the production of steviol glycosides resulted in the modification of food additive regulations. (foodlawlatest.com)
  • Here, kasugamycin was discovered to be a competitive inhibitor of glycoside hydrolase family 18 (GH18) chitinases from three different organisms (bacterium, insect and human). (frontiersin.org)
  • The glycoside hydrolase family 18 (GH18) chitinases (EC 3.2.1.14) are key enzymes that biodegrade chitin, which is the most abundant aminopolysaccharide in nature and composed of β-1,4-linked N -acetyl-D-glucosamine (GlcNAc). (frontiersin.org)
  • The large Glycoside Hydrolase family 5 (GH5) groups together a wide range of enzymes acting on β-linked oligo- and polysaccharides, and glycoconjugates from a large spectrum of organisms. (biomedcentral.com)
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  • The medicine digoxin contains cardiac glycosides. (medlineplus.gov)
  • Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth. (axonmedchem.com)
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  • Glycoside hydrolases (GHs) are the enzymes that catalyze the cleavage of glycosidic bonds, which link carbohydrate units to other biomolecules. (sfu.ca)
  • In the synthetic direction, phosphosugar-dependent glycosyltransferases (GTs) catalyze the formation of glycosidic linkages, whereas their breakdown is mediated by glycoside hydrolases (GHs) and polysaccharide lyases (PLs), with the assistance of carbohydrate esterases (CEs). (biomedcentral.com)
  • If triterpenoid it is called saponin glycoside e.g. glycyrrhizin, melanthin, ginsenoside. (solutionpharmacy.in)
  • The bioactivity of saponins: triterpenoid and steroidal glycosides. (bonaugure.com)
  • Saponins, tannins, anthraquinones and cardiac glycosides. (imguardian.org)
  • IMSEAR at SEARO: Antioxidant, antimicrobial activities of flavonoids glycoside from Leucaena leucocephala leaves. (who.int)
  • Mohammed Reda S, Souda Sahar S El, Taie Hanan A A, Moharam Maysa E, Shaker Kamel H. Antioxidant, antimicrobial activities of flavonoids glycoside from Leucaena leucocephala leaves. (who.int)
  • BEC is a plant extract obtainable from various Solanum species such as S. linnaeanum (Devil's Apple), S. nigrum (Black nightshade), S. melongena (Eggplant) and is composed of solasodine glycosides. (scirp.org)
  • However, identifying drugs with New targets for old drugs: cardiac glycosides inhibit atrial-specific k2p3. (bonaugure.com)
  • Hydrangea contains the hydragin poison i.e. a cyanogenic glycoside. (yardandgarage.com)
  • isolated a novel steroidal saponin glycoside from fagonia indica that can induce cell-selective apoptosis or necrosis in cancer cells. (imguardian.org)
  • Cardiac glycosides are found in several plants, including the leaves of the digitalis (foxglove) plant. (medlineplus.gov)
  • Besides the foxglove plant, cardiac glycosides also occur naturally in plants such as Lily-of-the-Valley and oleander , among several others. (medlineplus.gov)
  • Toxicity from herbal cardiac glycosides was well recognized by 1785, when William Withering published his classic work describing therapeutic uses and toxicity of foxglove, D purpurea . (medscape.com)
  • Time with extracts of the foxglove plant, which have cardiac glycosides. (imguardian.org)
  • A cardiac glycoside derived from the foxglove plant, digitalis purpurea. (bonaugure.com)
  • The structures were established by extensive NMR and MS experiments in combination with acid hydrolysis and sugar analysis by GC/MS. The new compounds were shown to be kaempferol and quercetin glycosides acylated for most of them by a branched short chain fatty acid or a hydroxycinnamic acid residue on the sugar portion. (unibas.ch)
  • J, labdane-type diterpene glycosides from leaves of Rubus chingii. (bvsalud.org)
  • Members contain stevioside and other sweet diterpene glycosides. (musc.edu)
  • The isolation of four novel acylated flavonoid glycosides from the roots of Saussurea lappa and their identification using a combination of 1D and 2D NMR and mass spectrometry is described. (mdpi.com)
  • Thirteen acylated flavonoid glycosides, 1-13, including eleven new congeners, 3-13, were isolated from the aerial parts of Pritzelago alpina (Brassicaceae) by a combination of column chromatography on Sephadex LH-20, and preparative and semi-preparative HPLC. (unibas.ch)
  • Cardiac glycosides: if levothyroxine therapy is initiated in digitalised patients, the dose of digitalis may require adjustment. (imguardian.org)
  • Digitalis glycosides. (who.int)
  • Kaempferol glycosides are functional components of jack bean. (envite.org)
  • A survey of plant extracts for the presence of p90 ribosomal S6 kinase (RSK) inhibitors resulted in the isolation of three acetylated flavonol glycosides. (elsevier.com)
  • Therapeutic use of herbal cardiac glycosides continues to be a source of toxicity today. (medscape.com)
  • Cardiac glycosides have been also found in Asian herbal products and have been a source of human toxicity. (medscape.com)
  • Toxicity may occur after consuming teas brewed from plant parts or after consuming leaves, flowers, or seeds from plants containing cardiac glycosides. (medscape.com)
  • Any dysrhythmia characterized by both increased automaticity and depressed conduction is suggestive of cardiac glycoside toxicity. (medscape.com)
  • Kanji S, Maclean RD. Cardiac glycoside toxicity: More than 200 years and counting. (cdc.gov)
  • Eleven phenolic acids and 17 anthocyanin 3-glycosides were identified and quantified. (nih.gov)
  • No effects were observed in these experiments where the exposure levels of trans-1,2-cyclohexanediol were extremely high compared to those in humans given the maximum therapeutic dose of CC, it is unlikely that CC would induce arrhythmias in clinical use even in patients treated with cardiac glycosides. (semanticscholar.org)
  • It's very difficult to classify the glycosides because if the classification is based on the sugar group then several rare sugars are involved and the structures of which are not well known. (solutionpharmacy.in)
  • A therapeutic classification is good from a pharmaceutical point of view which omits many glycosides of pharmacognostic interest. (solutionpharmacy.in)
  • Another classification of glycosides is based on the chemical group of the aglycone (Table 12.1). (farinelliandthekingbroadway.com)
  • Goal of the course is o form professional competencies in the system and give students knowledge and skills related to the classification, functions and chemical properties of glycosides, the specifics of glycoside production, quality control methods, and flowcharts for the production of drugs based on them. (tsukuba.ac.jp)
  • Other articles where steroid glycoside is discussed: steroid: cardiac glycosides and aglycones: …of the cardanolide type as glycosides (compounds that. (imguardian.org)
  • To test whether the antineoplastic, antipathogenic plant derived secondary metabolites, solasodine glycosides, can treat psoriasis. (scirp.org)
  • Cardiac glycosides are natural sterols and constitute a group of secondary metabolites isolated from plants and animals. (bonaugure.com)
  • Sterols and Steroidal Glycosides of Bulb Onion Seeds. (usda.gov)
  • Cardiac glycoside with direct inotropic effects in addition to indirect effects on cardiovascular system. (medscape.com)
  • Here we show that the second most abundant virion protein of pandoraviruses, major virion protein 2 (MVP2), evolved from an inactivated derivative of a bacterial glycoside hydrolase of the GH16 family. (pasteur.fr)
  • Neuraminic (sialic) acid based alpha-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. (rpi.edu)
  • Glycosides are acetals in which a hydroxyl group of sugar is attached with a hydroxyl group of a non-sugar component. (solutionpharmacy.in)
  • Glycosides are the naturally occurring organic compounds found in plants and some animals, which upon hydrolysis (either acid or enzymatic) give one or more sugar (glycone) moiety and non-sugar (aglycone) moiety. (solutionpharmacy.in)
  • Other sugars may be developed during hydrolysis then the term glycoside is applied. (solutionpharmacy.in)
  • Defination:-glycosides are define as organic compound from plants and animal source, which on enzymatic hydrolysis gives one or more sugar moieties along with anon sugar moiety. (farinelliandthekingbroadway.com)
  • Definition of glycoside : any of numerous sugar derivatives that contain a nonsugar group bonded to an oxygen or nitrogen atom and that on hydrolysis yield a sugar (such as glucose) Other Words from glycoside Example Sentences Learn More About glycoside. (farinelliandthekingbroadway.com)
  • Biologically, glycosides have a role in plant life include regulatory, protective, and sanitary functions. (solutionpharmacy.in)
  • They contain cardiac glycoside toxins, which directly interfere with heart muscle function. (thebugmaster.com)
  • More than 200 naturally occurring cardiac glycosides have been identified. (medscape.com)
  • The cardiac glycosides are an important class of naturally occurring drugs whose actions include both beneficial and toxic effects on the heart. (bonaugure.com)
  • Plants produce compounds known as aroma glycosides, which contain a sugar component linked to a volatile aromatic compound. (thesaurus.com)
  • Three New Flavone Glycosides from Drymaria diandra Bl. (jipb.net)
  • Horsetail possesses diuretic properties, which are believed to be due to equisetonin and flavone glycosides 7 . (ijpjournal.com)
  • The occurrence of these pregnane compounds indicates that they might be internally biosynthesized in the plant from furostanol glycosides by a reaction that. (imguardian.org)
  • Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the. (bonaugure.com)
  • Effect of sun exposure on carotenoids and C13-norisoprenoid glycosides in Syrah berries (Vitis vinifera L. (inrae.fr)
  • Effect of sun exposure on carotenoids and C13-norisoprenoid glycosides in Syrah berries (Vitis vinifera L.). Sciences des Aliments , 1998, 18 (4), pp.361-373. (inrae.fr)
  • The most frequently occurring sugar is β-D-glucose, although rhamnose, digitoxose, cymarose, and other sugars are components of glycosides. (solutionpharmacy.in)