OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
GlycopeptidesOligosaccharidesCarbohydrate ConformationMannosePronaseCarbohydrate SequenceFucoseTeicoplaninCarbohydratesGlycoproteinsGlycosylationPolysaccharidesAsparagineSialic AcidsGlucosamineVancomycinChromatography, GelNeuraminic AcidsAmino SugarsGlycoside HydrolasesGalactoseAcetylgalactosamineLectinsMucinsChromatography, AffinityAnti-Bacterial AgentsMannosidasesMolecular Sequence DataPlant LectinsAcetylglucosamineAcetylglucosaminidaseOvomucinPeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidaseMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseAmino AcidsAmino Acid SequenceFetuinsChromatography, High Pressure LiquidConcanavalin ACarbon-Oxygen LigasesHexosaminesTrypsinHexosesEnterococcusMass SpectrometryStaphylococcus haemolyticusPeriodic AcidMolecular WeightMannosidesMonosaccharidesMicrobial Sensitivity TestsHexosaminidasesGram-Positive Bacterial Infectionsalpha-MannosidaseGlycomicsVancomycin ResistanceChemistryN-Acetylneuraminic AcidGlycosidesChromatography, PaperChemical PhenomenaAntigens, Tumor-Associated, CarbohydrateStaphylococcal InfectionsMucin-1NeuraminidaseAsialoglycoproteinsHydroxylysineSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationChromatography, Ion ExchangeStaphylococcus aureusTandem Mass SpectrometryGalactose OxidaseAcetamidesMagnetic Resonance SpectroscopyMNSs Blood-Group SystemEnterococcus faeciumSuccinic AnhydridesOxazolidinonesMethicillin Resistancealpha-L-FucosidasePeptide FragmentsSulfuric AcidsGalactosamineAntifreeze ProteinsBlood Group AntigensGram-Positive BacteriaDrug Resistance, MicrobialCattlealpha-Fetoproteins
Glycopeptides
Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.
Oligosaccharides
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
Carbohydrate Conformation
The characteristic 3-dimensional shape of a carbohydrate.
Mannose
A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)
Pronase
A proteolytic enzyme obtained from Streptomyces griseus.
Carbohydrate Sequence
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
Fucose
Teicoplanin
Glycopeptide antibiotic complex from Actinoplanes teichomyceticus active against gram-positive bacteria. It consists of five major components each with a different fatty acid moiety.
Carbohydrates
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Glycoproteins
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Glycosylation
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Polysaccharides
Asparagine
A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Sialic Acids
A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.
Glucosamine
Vancomycin
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
Chromatography, Gel
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
Neuraminic Acids
Amino Sugars
SUGARS containing an amino group. GLYCOSYLATION of other compounds with these amino sugars results in AMINOGLYCOSIDES.
Glycoside Hydrolases
Galactose
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
Acetylgalactosamine
The N-acetyl derivative of galactosamine.
Lectins
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Mucins
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Chromatography, Affinity
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Mannosidases
Glycoside hydrolases that catalyze the hydrolysis of alpha or beta linked MANNOSE.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Plant Lectins
Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.
Acetylglucosamine
The N-acetyl derivative of glucosamine.
Acetylglucosaminidase
A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.
Ovomucin
A heterogeneous mixture of glycoproteins responsible for the gel structure of egg white. It has trypsin-inhibiting activity.
Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
An amidohydrolase that removes intact asparagine-linked oligosaccharide chains from glycoproteins. It requires the presence of more than two amino-acid residues in the substrate for activity. This enzyme was previously listed as EC 3.2.2.18.
Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
A group of related enzymes responsible for the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose-content glycopeptides and GLYCOPROTEINS.
Amino Acids
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Fetuins
A family of calcium-binding alpha-globulins that are synthesized in the LIVER and play an essential role in maintaining the solubility of CALCIUM in the BLOOD. In addition the fetuins contain aminoterminal cystatin domains and are classified as type 3 cystatins.
Chromatography, High Pressure Liquid
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Concanavalin A
A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
Carbon-Oxygen Ligases
Enzymes that catalyze the joining of two molecules by the formation of a carbon-oxygen bond. EC 6.1.
Hexosamines
Trypsin
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
Hexoses
Enterococcus
A genus of gram-positive, coccoid bacteria consisting of organisms causing variable hemolysis that are normal flora of the intestinal tract. Previously thought to be a member of the genus STREPTOCOCCUS, it is now recognized as a separate genus.
Mass Spectrometry
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Staphylococcus haemolyticus
A species of STAPHYLOCOCCUS found on the skin of humans (and non-human primates), often causing hospital-acquired infections (CROSS INFECTION).
Periodic Acid
A strong oxidizing agent.
Molecular Weight
The sum of the weight of all the atoms in a molecule.
Mannosides
Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with an alcohol to form an acetal. They include both alpha- and beta-mannosides.
Monosaccharides
Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)
Microbial Sensitivity Tests
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Hexosaminidases
Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminidases also act on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES.
Gram-Positive Bacterial Infections
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.
alpha-Mannosidase
An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
Glycomics
The systematic study of the structure and function of the complete set of glycans (the glycome) produced in a single organism and identification of all the genes that encode glycoproteins.
Vancomycin Resistance
Nonsusceptibility of bacteria to the action of VANCOMYCIN, an inhibitor of cell wall synthesis.
Chemistry
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
N-Acetylneuraminic Acid
An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
Glycosides
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Chromatography, Paper
An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).
Chemical Phenomena
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
Antigens, Tumor-Associated, Carbohydrate
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.
Mucin-1
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
Neuraminidase
An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)
Asialoglycoproteins
Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.
Hydroxylysine
A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens.
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
Chromatography, Ion Exchange
Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.
Staphylococcus aureus
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
Tandem Mass Spectrometry
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Galactose Oxidase
An enzyme that oxidizes galactose in the presence of molecular oxygen to D-galacto-hexodialdose. It is a copper protein. EC 1.1.3.9.
Acetamides
Derivatives of acetamide that are used as solvents, as mild irritants, and in organic synthesis.
Magnetic Resonance Spectroscopy
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
MNSs Blood-Group System
A system of universal human blood group isoantigens with many associated subgroups. The M and N traits are codominant and the S and s traits are probably very closely linked alleles, including the U antigen. This system is most frequently used in paternity studies.
Enterococcus faecium
A species of gram-positive, coccoid bacteria whose organisms are normal flora of the intestinal tract. Unlike ENTEROCOCCUS FAECALIS, this species may produce an alpha-hemolytic reaction on blood agar and is unable to utilize pyruvic acid as an energy source.
Succinic Anhydrides
A subclass of anhydrides with the general structure of dihydrofurandione. They can be substituted on any carbon atom. They modify and inhibit proteins and enzymes and are used in the acylation of amino- and hydroxyl groups.
Oxazolidinones
Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.
Methicillin Resistance
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
alpha-L-Fucosidase
An enzyme that catalyzes the hydrolysis of an alpha L-fucoside to yield an alcohol and L-fucose. Deficiency of this enzyme can cause FUCOSIDOSIS. EC 3.2.1.51.
Peptide Fragments
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Sulfuric Acids
Inorganic and organic derivatives of sulfuric acid (H2SO4). The salts and esters of sulfuric acid are known as SULFATES and SULFURIC ACID ESTERS respectively.
Galactosamine
Antifreeze Proteins
Proteins that bind to ice and modify the growth of ice crystals. They perform a cryoprotective role in a variety of organisms.
Blood Group Antigens
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
Gram-Positive Bacteria
Bacteria which retain the crystal violet stain when treated by Gram's method.
Drug Resistance, Microbial
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Cattle
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
alpha-Fetoproteins
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.

Glycopeptides from the surgace of human neuroblastoma cells. (1/2148)

Glycopeptides suggesting a complex oligosaccharide composition are present on the surface of cells from human neuroblastoma tumors and several cell lines derived from the tumors. The glycopeptides, labeled with radioactive L-fucose, were removed from the cell surface with trypsin, digested with Pronase, and examined by chromatography on Sephadex G-50. Human skin fibroblasts, brain cells, and a fibroblast line derived from neuroblastoma tumor tissue show less complex glycopeptides. Although some differences exist between the cell lines and the primary tumor cells, the similarities between these human tumors and animal tumors examined previously are striking.  (+info)

Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL. (2/2148)

T cell receptor (TCR) recognition of nonpeptidic and modified peptide antigens has been recently uncovered but is still poorly understood. Immunization with an H-2Kb-restricted glycopeptide RGY8-6H-Gal2 generates a population of cytotoxic T cells that express both alpha/beta TCR, specific for glycopeptide, and gamma/delta TCR, specific for the disaccharide, even on glycolipids. The crystal structure of Kb/RGY8-6H-Gal2 now demonstrates that the peptide and H-2Kb structures are unaffected by the peptide glycosylation, but the central region of the putative TCR binding site is dominated by the extensive exposure of the tethered carbohydrate. These features of the Kb/RGY8-6H-Gal2 structure are consistent with the individual ligand binding preferences identified for the alpha/beta and gamma/delta TCRs and thus explain the generation of a carbohydrate-specific T cell response.  (+info)

Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity. (3/2148)

Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand.  (+info)

The structure of a glycopeptide (GP-II) isolated from Rhizopus saccharogenic amylase. (4/2148)

Mild alkaline treatment of glycopeptide (GP-II) resulted in the loss of 1 mole of serine and 5 moles of threonine per mole of GP-II, suggesting the presence of O-glycosyl bonds between 1 serine and 5 threonine residues and carbohydrate chains. Treatment of GP-II with alkaline borohydride released only disaccharide. Methylation studies of the carbohydrate moiety gave 2,3,4,6-tetra-O-methyl and 2,4,6-tri-O-methyl derivatives of mannose in a ratio of approximately 1:1. In addition, one step of Smith degradation resulted in the loss of about 6 residues of mannose per mole of GP-II. Moreover, alpha-mannosidase [EC 3.2.1.24] liberated about 6 residles of mannose per mole of GP-II. On the basis of these data, the structure of the carbohydrate moiety of GP-II was confirmed to be 3-O-alpha-mannosylmannose. The amino- and carboxyl-terminal amino acids of GP-II were determined to be threonine and serine, respectively. On reductive cleavage of N-proline bonds with metallic sodium in liquid ammonia, 2 moles of alanine per mole of GP-II were lost. From the compositions of three fragments isolated from the reductive cleavage products, the amino acid sequence of the peptide portion of GP-II was determined. Based on these data, a probable structure was proposed for GP-II.  (+info)

Participation of a trisaccharide-lipid in glycosylation of oviduct membrane glycoproteins. (5/2148)

Preincubation of a hen oviduct membrane preparation with UDP-Nactyl[14C]glucosamine and bacitracin, followed by incubation with GDP-mannose, leads to formation of a chloroform/methanol (2/1)-extractable glycolipid. Treatment of the lipid with mild acid results in the release of a trisaccharide shown to have the structure beta-mannosyl-N-acetylglucosamineyl-N-acetylglucosamine. Incubation of purified trisaccharide-lipid with oviduct membranes in the presence of sodium deoxycholate, Mn2+, and GDP-mannose leads to formation of a labeled glycoprotein with an apparent molecular weight of 25,000...  (+info)

Synergy of an investigational glycopeptide, LY333328, with once-daily gentamicin against vancomycin-resistant Enterococcus faecium in a multiple-dose, in vitro pharmacodynamic model. (6/2148)

The pharmacodynamics of an investigational glycopeptide, LY333328 (LY), alone and in combination with gentamicin, against one vancomycin-susceptible and two vancomycin-resistant Enterococcus faecium strains were studied with a multiple-dose, in vitro pharmacodynamic model (PDM). Dose-range data for the PDM studies were obtained from static time-kill curve studies. In PDM experiments conducted over 48 h, peak LY concentrations of 0.1x and 1x the MIC every 24 h and peak gentamicin concentrations of 18 micrograms/ml every 24 h (Gq24 h) and 6 micrograms/ml every 8 h (Gq8 h) were studied alone and in the four possible LY-gentamicin combinations. Compared to either antibiotic alone, LY-gentamicin combination regimens produced significantly higher apparent killing rates (KRs) calculated during the initial 2 h postdosing. The mean KRs for LY or gentamicin alone versus those for the LY-gentamicin combination regimens were 0.35 +/- 0.55 log10 CFU/ml/h (95% confidence interval [CI95%], 0 to 0.70) and 1.46 +/- 0.71 log10 CFU/ml/h (CI95%, 1.01 to 1.91), respectively (P < 0.0001). Bacterial killing at 48 h (BK48), which was calculated by subtracting the bacterial counts at 48 h from the initial inoculum, with a negative value indicating net growth, was also significantly greater. The mean BK48S were -0.69 +/- 0.44 log10 CFU/ml (CI95%, -0.41 to -0.97) and 3.72 +/- 2.28 log10 CFU/ml (CI95%, 2.28 to 5.17) for LY or gentamicin alone versus LY-gentamicin combination regimens, respectively (P < 0.0001). None of the 12 regimens with LY or gentamicin alone but 75% (9 of 12) of the LY-gentamicin combination regimens were bactericidal. Eighty-three percent (10 of 12) of the LY-gentamicin combination regimens also demonstrated synergy. No significant differences between the pharmacodynamics of LY-gentamicin combination regimens containing Gq24 h versus those containing Gq8h were detected.  (+info)

Evaluation of bactericidal activities of LY333328, vancomycin, teicoplanin, ampicillin-sulbactam, trovafloxacin, and RP59500 alone or in combination with rifampin or gentamicin against different strains of vancomycin-intermediate Staphylococcus aureus by time-kill curve methods. (7/2148)

This in vitro study evaluated the activities of vancomycin, LY333328, and teicoplanin alone and in combination with gentamicin, rifampin, and RP59500 against Staphylococcus aureus isolates with intermediate susceptibilities to vancomycin. Ampicillin-sulbactam and trovafloxacin were also evaluated. LY333328 and ampicillin-sulbactam resulted in bactericidal activity against all isolates. The combination of gentamicin with glycopeptides showed synergistic activity, while rifampin had no added benefit.  (+info)

Evidence for an adenovirus type 2-coded early glycoprotein. (8/2148)

We have identified an adenovirus type 2 (Ad2)-induced early glycopolypeptide with an apparent molecular weight of 20,000 to 21,000 (20/21K), as estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The 20/21K polypeptide could be labeled in vivo with [(3)H]glucosamine. [(35)S]methionine- and [(3)H]-glucosamine-labeled 20/21K polypeptides bound to concanavalin A-Sepharose columns and were eluted with 0.2 M methyl-alpha-d-mannoside. The pulse-labeled polypeptide appeared as a sharp band with an apparent molecular weight of 21K, but after a chase it converted to multiple bands with an average molecular weight of 20K. This variability in electrophoretic mobility is consistent with glycosylation or deglycosylation of the 20/21K polypeptide. Analysis of the pulse and pulse-chase-labeled forms by using partial proteolysis indicated that the polypeptides were highly related chemically, but not identical. Most of the 20/21K polypeptide is localized in the cytoplasm fraction of infected cells lysed by Nonidet P-40. The 20/21K polypeptide and a 44K polypeptide, labeled with [(35)S]methionine or [(3)H]glucosamine in Ad2-infected human cells, were precipitated by a rat antiserum against an Ad2-transformed rat cell line (T2C4), but not by antisera against three other Ad2-transformed rat cell lines, or by serum from nonimmune rats. The partial proteolysis patterns of the 20/21K and the 44K polypeptides were indistinguishable, indicating that the two polypeptides are highly related, and suggesting that the 44K polypeptide might be a dimer of the 20/21K polypeptide. The 20/21K polypeptide was also induced in Ad2-early infected monkey and hamster cells. These results imply that the 20/21K polypeptide is synthesized in Ad2-infected human, monkey, and hamster cells, and in one but not all Ad2-transformed rat cells. Thus, the 20/21K polypeptide is probably viral coded rather than cell coded and viral induced.  (+info)

Characterization of Glycan Binding Site of O-Linked Glycopeptides Using MALDI-7090 High-Resolution MALDI-TOF MS - Related...Characterization of Glycan Binding Site of O-Linked Glycopeptides Using MALDI-7090 High-Resolution MALDI-TOF MS - Related...
This page is Related Information of Characterization of Glycan Binding Site of O-Linked Glycopeptides Using MALDI-7090 High-Resolution MALDI-TOF MS.
https://www.shimadzu.com/an/industries/life-science/life-science-proteomics/characterization-of-glycan/related-information.html
Glycopeptides Are No More Effective than β-Lactam Agents for Prevention of Surgical Site Infection after Cardiac Surgery: A...
A meta-analysis was performed to investigate whether a switch from β-lactams to glycopeptides for cardiac surgery prophylaxis should be advised. Results of 7 randomized trials (5761 procedures) that compared surgical site infections (SSIs) in subjects receiving glycopeptide prophylaxis with SSIs in those who received β-lactam prophylaxis were pooled. Neither agent proved to be superior for prevention of the primary outcome, occurrence of SSI at 30 days (risk ratio [RR], 1.14; 95% confidence interval [CI], 0.91-1.42). In subanalyses, β-lactams were superior to glycopeptides for prevention of chest SSIs (RR, 1.47; 95% CI, 1.11-1.95) and approached superiority for prevention of deep-chest SSIs (RR, 1.33; 95% CI, 0.91-1.94) and SSIs caused by gram-positive bacteria (RR, 1.36; 95% CI, 0.98-1.91). Glycopeptides approached superiority to β-lactams for prevention of leg SSIs (RR, 0.77; 95% CI, 0.58-1.01) and were superior for prevention of SSIs caused by methicillin-resistant gram-positive bacteria ...
http://oxfordindex.oup.com/view/10.1086/383318
One-Step Enrichment of Intact Glycopeptides From Glycoengineered Chinese Hamster Ovary Cells<...
TY - JOUR. T1 - One-Step Enrichment of Intact Glycopeptides From Glycoengineered Chinese Hamster Ovary Cells. AU - Yang, Ganglong. AU - Höti, Naseruddin. AU - Chen, Shao Yung. AU - Zhou, Yangying. AU - Wang, Qiong. AU - Betenbaugh, Michael. AU - Zhang, Hui. PY - 2020/4/17. Y1 - 2020/4/17. N2 - Recently, the glycoproteomic analysis of intact glycopeptides has emerged as an effective approach to decipher the glycan modifications of glycoproteins at the site-specific level. A rapid method to enrich intact glycopeptides is essential for the analysis of glycoproteins, especially for biopharmaceutical proteins. In this study, we established a one-step method for the rapid capture of intact glycopeptides for analysis by mass spectrometry. Compared to the conventional sequential enrichment method, the one-step intact glycopeptide enrichment method reduced the sample preparation time and improved the detection of intact glycopeptides with long sequences or non-polar amino acids. Moreover, an increased ...
https://jhu.pure.elsevier.com/en/publications/one-step-enrichment-of-intact-glycopeptides-from-glycoengineered-
Molecular basis of antibody binding to mucin glycopeptides in lung cancer<...
TY - JOUR. T1 - Molecular basis of antibody binding to mucin glycopeptides in lung cancer. AU - Qu, Jin. AU - Yu, Hongtao. AU - Li, Fenge. AU - Zhang, Chunlei. AU - Trad, Ahmad. AU - Brooks, Cory. AU - Zhang, Bin. AU - Gong, Ting. AU - Guo, Zhi. AU - Li, Yunsen. AU - Ragupathi, Govind. AU - Lou, Yanyan. AU - Hwu, Patrick. AU - Huang, Wei. AU - Zhou, Dapeng. PY - 2016/2. Y1 - 2016/2. N2 - Glycopeptides bearing Tn epitopes are emerging targets for cancer diagnosis and immunotherapy. In this study, we analyzed membrane proteins containing O-glycosylated tandem repeat (TR) sequences in lung cancer patients of different types and stages, using gene microarray data in public domain. The expression of Tn and glycopeptide epitopes on the surface of lung cancer cell lines were studied by monoclonal IgG antibodies 14A, 16A, and B72.3. The binding of mAbs to synthetic glycopeptides were studied by surface plasmon resonance. Nine mucin mRNAs were found to be expressed in lung cancer patients but at similar ...
https://www.scholars.northwestern.edu/en/publications/molecular-basis-of-antibody-binding-to-mucin-glycopeptides-in-lun
Formation of homogeneous cross-linked lattices between oligomannose type glycopeptides and concanavalin A<...Formation of homogeneous cross-linked lattices between oligomannose type glycopeptides and concanavalin A<...
TY - JOUR. T1 - Formation of homogeneous cross-linked lattices between oligomannose type glycopeptides and concanavalin A. AU - Islam Khan, M.. AU - Bhattacharyya, Lokesh. AU - Brewer, Curtis F.. PY - 1988/5/16. Y1 - 1988/5/16. N2 - Certain oligomannose type glycopeptides have previously been shown to be bivalent for binding to concanavalin A, and to give quantitative precipitation profiles with the protein that consist of single peaks which correspond to the binding stoichiometry of glycopeptide to protein monomer (1:2) (Bhattacharyya, L., Ceccarini, C., Lorenzoni, P., and Brewer, C.F. (1987) J. Biol. Chem. 262, 1288-1293). In the present study, equimolar mixtures of two oligomannose type glycopeptides, a Man-6 and a Man-9 glycopeptide, gives a quantitative precipitation profile which shows two protein peaks. Each glycopeptide was radiolabelled with 3H or 14C, and the the precipitation profiles of the individual glycopeptides in the mixture determined. The results show that the radioactivity ...
https://einstein.pure.elsevier.com/en/publications/formation-of-homogeneous-cross-linked-lattices-between-oligomanno-2
Copeptin, the C-terminal section of provasopressin, has emerged as a novel | immune-source.comCopeptin, the C-terminal section of provasopressin, has emerged as a novel | immune-source.com
immune Uncategorized Mouse monoclonal to IGFBP2, Ziprasidone manufacture Copeptin, the C-terminal section of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in Ziprasidone manufacture Mouse monoclonal to IGFBP2 patients with acute stroke. Stroke is a disastrous disease; it is one of the leading causes of death and serious disability worldwide1. Mortality after 1 year ranges between 21% and 27%; approximately 15% to 30% of stroke survivors are permanently disabled1. It is necessary to evaluate prognostic factors to predict functional outcomes and mortality after stroke, which could be effective in creating therapeutic strategies and improving survival rates. Patient age and stroke ...
http://www.immune-source.com/2017/08/copeptin-the-c-terminal-section-of-provasopressin-has-emerged-as-a-novel/
Partial characterization of the oligosaccharides of mouse thymocyte Thy-1 glycoprotein | Biochemical JournalPartial characterization of the oligosaccharides of mouse thymocyte Thy-1 glycoprotein | Biochemical Journal
Four glycopeptides (I, IIA, IIB, III) with different oligosaccharide structures were isolated from purified mouse thymocyte Thy-1 glycoprotein. The glycoprotein was digested with Pronase, and the glycopeptide fraction was isolated by gel filtration and acetylated with [3H]acetic anhydride. The different glycan structures were separated by affinity chromatography on concanavalin A-Sepharose 4B and lentil lectin-Sepharose 4B. Size determinations of intact and exoglycosidase- and endoglycosidase-digested glycopeptides were performed by gel filtration on Bio-Gel P-6, calibrated with glycopeptides of known structure. On the basis of these experiments and on the behaviour of the glycopeptides on the lectin columns, the following structures of the oligosaccharide chains were proposed: I, triantennary complex-type with terminal fucose; IIA, biantennary complex-type without fucose; IIB, biantennary complex-type with fucose; III, a mixture of high-mannose chains containing either five or six ...
http://www.biochemj.org/content/221/2/379
Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin : The H2O Metabolism Pilot StudyWater Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin : The H2O Metabolism Pilot Study
article{e00c4d89-ef12-4d42-9fc1-b94975575fa4, abstract = {,p,OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose.,/p,,p,DESIGN, SETTING, AND PARTICIPANTS: Thirty-one healthy adults with high copeptin (>10.7 pmol · L-1 in men and >6.1 pmol·L-1 in women) identified in a population-based survey from 2013 to 2015 and with a current 24-hour urine osmolality of >600 mOsm · kg-1 were included.,/p,,p,INTERVENTION: Addition of 1.5 L water daily on top of habitual fluid intake for 6 weeks.,/p,,p,MAIN OUTCOME MEASURE: Pre- and postintervention fasting plasma copeptin concentrations.,/p,,p,RESULTS: Reported mean water intake increased from 0.43 to 1.35 L · d-1 (P < 0.001), with no other observed changes in diet. Median (interquartile range) urine osmolality was reduced from 879 (705, 996) to 384 (319, 502) mOsm · kg-1 (P < 0.001); urine volume ...
https://lup.lub.lu.se/search/publication/e00c4d89-ef12-4d42-9fc1-b94975575fa4
Search of: Recruiting, Not yet recruiting, Available Studies | Diabetes Insipidus - List Results - ClinicalTrials.govSearch of: Recruiting, Not yet recruiting, Available Studies | Diabetes Insipidus - List Results - ClinicalTrials.gov
Correlation between plasma copeptin levels and other markers used in management of diabatic ketoacidosis in the first 36 hours after diagnosis- Plasma copeptin levels at diagnosis of diabate mellitus type 1 without ketoacidosis in ...
https://clinicaltrials.gov/ct2/results?recr=Open&cond=%22Diabetes+Insipidus%22&show_rss=Y&sel_rss=new14
Creative Peptides Has Released New Discovery in Glycopeptide SynthesisCreative Peptides Has Released New Discovery in Glycopeptide Synthesis
August 19th, 2016 - Creative Peptides, a professional supplier of peptides manufacturing upon academic, clinical, commercial and government laboratories in diverse applications, has released its efficient Glycopeptide Synthesis service, to help speed up the advance in solid phase methods. Nowadays, glycopeptides have played a pivotal role in a myriad of organisms and systems, such as biology, physiology, medicine, bioengineering and technology, etc. As is known, synthetic glycopeptides are able to offer an unique frontier for research in glycobiology and proteomics as well as for drug discovery & development, drug delivery & targeting, diagnostics development and biotechnological applications, which also promotes the development of modern biomarker discovery process. Based on rapid achievements in peptides research, increasing number of scientists are trying to discover more effective methods in modern scientific research, such as deslorelin acetate, aviptadil acetate, Chimeric Peptides, and so on.
https://lifeboat.com/blog/2016/08/creative-peptides-has-released-new-discovery-in-glycopeptide-synthesis
Ligand-free strategy for ultrafast and highly selective enrichment of glycopeptides using Ag-coated magnetic nanoarchitectures ...Ligand-free strategy for ultrafast and highly selective enrichment of glycopeptides using Ag-coated magnetic nanoarchitectures ...
Selective enrichment of glycopeptides from complicated biological samples is essential for MS-based glycoproteomics, but still remains a great challenge. In this study, we report an unprecedented ligand-free strategy for the selective enrichment of glycopeptides by simply utilizing the multivalent interactio
http://pubs.rsc.org/en/Content/ArticleLanding/2012/JM/c2jm35196j
Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins - Chemical Communications (RSC...Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins - Chemical Communications (RSC...
A number of recent advances in the chemical synthesis of glycopeptides and glycoproteins are described, with particular focus on the development of peptide ligation strategies and their implementation in the convergent assembly of complex glycopeptides. Recent applications in the synthesis of full length homogeneou RACI100: Celebrating Australian Chemistry
http://pubs.rsc.org/en/Content/ArticleLanding/2010/CC/b913845e
Edible Birds Nest: Physicochemical Properties, Production, and Application of Bioactive Extracts and Glycopeptides<...
TY - JOUR. T1 - Edible Birds Nest. T2 - Physicochemical Properties, Production, and Application of Bioactive Extracts and Glycopeptides. AU - Daud, NurAliah. AU - Mohamad Yusop, Salma. AU - Babji, Abdul Salam. AU - Lim, Seng Joe. AU - Sarbini, Shahrul Razid. AU - Hui Yan, Tan. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Edible birds nest (EBN), the swiftlets nest, has been consumed for centuries as a tonic or health food. The information upon the usage and benefits of the EBN are largely based on historical and observational reports since its discovery, until some were proven scientifically at recent times. Studies have been conducted on the major components of the EBN, i.e. glycoprotein, in attempts to elucidate the roles of the glycoprotein in terms of functionality toward health improvement. This article presents a review of the physicochemical and nutritional composition of EBN from different harvested locations and its functional properties. The conversion of EBN glycoproteins to glycopeptides ...
https://ukm.pure.elsevier.com/en/publications/edible-birds-nest-physicochemical-properties-production-and-appli
Identification of O-glycosylated decapeptides within the MUC1 repeat domain as potential MHC class I (A2) binding epitopes<...
TY - JOUR. T1 - Identification of O-glycosylated decapeptides within the MUC1 repeat domain as potential MHC class I (A2) binding epitopes. AU - Ninkovic, Tanja. AU - Kinarsky, Leo. AU - Engelmann, Katja. AU - Pisarev, Vladimir. AU - Sherman, Simon. AU - Finn, Olivera J.. AU - Hanisch, Franz Georg. N1 - Funding Information: The work was supported by NIH grant 1RO1 CA84106 and the Köln-Fortune Programme (to F.G.H.) and by NIH grant 2PO CA73743 (to O.J.F.).. PY - 2009/11. Y1 - 2009/11. N2 - The MUC1 glycoprotein is considered a tumor antigen due to its over expression and aberrant glycosylation in cancer tissues. The latter results in appearance of new antigenic tumor specific glycopeptides not found on normal glycoforms of the mucin. MUC1 glycopeptides can be presented by APCs on MHC class II molecules to activate glycopeptide specific helper T-cells. No study has yet reported presentation of MUC1 glycopeptides on MHC class I molecules as stimulators of cytotoxic T-cells. In this study we show ...
https://experts.nebraska.edu/en/publications/identification-of-o-glycosylated-decapeptides-within-the-muc1-rep
Sexual disparity of copeptin in healthy newborn infants - Zurich Open Repository and ArchiveSexual disparity of copeptin in healthy newborn infants - Zurich Open Repository and Archive
RESULTS: Multivariable linear regression analysis revealed stressful delivery (regression coefficient β = .569, P ,0.001), acidosis (β = -.347, P , .001), and male gender (β = .132, P , .01) as independent determinants of copeptin at birth. In infants born without stress, that is by primary cesarean section (n = 81), male gender was the sole variable associated with copeptin (β = .286, P , .05), copeptin concentrations being higher in boys [median 5.5 pmol/L (interquartile range 4.4-10.2)] than in girls [4.8 pmol/L (interquartile range 3.6-5.8), P , .05]. At day 3 of life, copeptin was determined independently by postnatal physiological dehydration (β = .485; P , .001) and birth weight (β = .279; P , .01 ...
http://www.zora.uzh.ch/id/eprint/103489/
Site-Specific Glycoprofiling of N-Linked Glycopeptides Using MALDI-TOF MS: Strong Correlation between Signal Strength and...Site-Specific Glycoprofiling of N-Linked Glycopeptides Using MALDI-TOF MS: Strong Correlation between Signal Strength and...
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https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_ac900231w
Convergent Chemoenzymatic Synthesis of Glycopeptides and Glycoproteins - Lai-Xi WangConvergent Chemoenzymatic Synthesis of Glycopeptides and Glycoproteins - Lai-Xi Wang
The goal of the proposed research is to develop a general and highly efficient chemo enzymatic method for making diverse homogeneous glycopeptides and glycoprot...
http://grantome.com/grant/NIH/R01-GM080374-07
A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as...A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as...
We report here the use of TEV protease cleavable fusion proteins to produce glycosylated bioactive peptides and proteins. Bacterial expression was utilized to produce two fusion proteins, GPRT-C37-H6 and His-tagged interleukin-2 (amino acids 6-133), which when cleaved by the tobacco etch virus NIa protease (TEV protease) to generate HIV entry inhibitor peptide C37-H6 and a truncated version of the cytokine interleukin-2, both containing N-terminal cysteines. The N-terminal cysteine containing C37-H6 and truncated interleukin-2 were then joined to a synthetic glycopeptide thioester utilizing native chemical ligation under nondenaturing and denaturing conditions, respectively. The ligations of the glycopeptide to the C37-H6 peptide and the truncated interleukin-2 protein both proceeded in high yield, though the size, and physical properties of the two polypeptides differ greatly ...
https://vivo.scripps.edu/display/endnote209989
Synthesis of glycopeptides containing carbohydrate and peptide recognition motifs. Novel enzymatic mechanisms in carbohydrate...Synthesis of glycopeptides containing carbohydrate and peptide recognition motifs. Novel enzymatic mechanisms in carbohydrate...
Synthesis of glycopeptides containing carbohydrate and peptide recognition motifs. Novel enzymatic mechanisms in carbohydrate metabolism
http://www.readabstracts.com/Chemistry/Synthesis-of-glycopeptides-containing-carbohydrate-and-peptide-recognition-motifs.html
Kanwaljeet Kaur | NIIKanwaljeet Kaur | NII
Antimicrobial glycopeptides of innate immune origin : The resistance of insects to bacterial infection is explained by their ability to synthesize a diverse range of antibacterial peptides. A remarkable feature of some proline rich antibacterial peptides such as drosocin, pyrrhocoricin, formaecins, diptericin and lebocins which have been isolated from insects, is the presence of conserved O-glycosylated threonine residue and the integrity of the carbohydrate side chain is necessary for their maximum activity. The exact role of the sugar remains an enigma. We are addressing the problem of role of carbohydrate domains in the activity of antimicrobial glycopeptides by studying their structure-function relationship. However, the mode of action of this class of cationic antimicrobial glycopeptides is not known completely and they are thought to kill bacteria by entering cells and binding to target/targets. The studies addressing mechanistic aspects are also undertaken and are in progress for the ...
http://www1.nii.res.in/research/kanwaljeet-kaur
Copeptin and Long-Term Risk of Recurrent Vascular Events After Transient Ischemic Attack and Ischemic Stroke | StrokeCopeptin and Long-Term Risk of Recurrent Vascular Events After Transient Ischemic Attack and Ischemic Stroke | Stroke
To control for potential effects on mortality because of reverse causation, we did a sensitivity analysis excluding patients with major stroke, but results remained qualitatively unchanged (Table 2). In addition, analysis of copeptin by tertiles or by using the 90th percentile of copeptin levels in controls (8.11 pmol/L) in patients revealed similar results (all vascular events: top tertile versus lowest tertile: adjusted HR, 1.91; 95% CI, 1.43-2.53; P,0.0001 and 90th percentile of controls in patients: adjusted HR, 1.76; 1.41-2.20; P,0.0001; Table I in the online-only Data Supplement). Use of the 95th percentile of controls (10.67 pmol/L) in patients revealed practically identical results (all vascular events: adjusted HR, 1.76; 1.40-2.21). The absolute 5-year risk for recurrent vascular events was 0.38 (95% CI, 0.33-0.42) for patients with copeptin levels ≥90th percentile in controls and 0.21 (0.18-0.25) for patients with levels below (Table II in the online-only Data Supplement).. Levels of ...
http://stroke.ahajournals.org/content/46/11/3117
Analysis of Glycopeptides of Monoclonal Antibody Using MALDI-7090 High-Resolution MALDI-TOF MS - Related Information :...Analysis of Glycopeptides of Monoclonal Antibody Using MALDI-7090 High-Resolution MALDI-TOF MS - Related Information :...
This page is Related Information of Analysis of Glycopeptides of Monoclonal Antibody Using MALDI-7090 High-Resolution MALDI-TOF MS.
https://www.shimadzu.com/an/industries/life-science/life-science-proteomics/glycopeptides-of-m/related-information.html
Glycopeptides and Lipoglycopeptides - Infections - MSD Manual Consumer VersionGlycopeptides and Lipoglycopeptides - Infections - MSD Manual Consumer Version
Glycopeptides and Lipoglycopeptides - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer Version.
https://www.msdmanuals.com/en-in/home/infections/antibiotics/glycopeptides-and-lipoglycopeptides
Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide | Science Translational MedicineMimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide | Science Translational Medicine
Fig. 3. Isolation and characterization of N332-dependent antibodies isolated using native-like SOSIP trimers and synthetic Man9-V3 glycopeptide.. (A) ELISA binding analyses of plasma from the HIV-infected donor CH765 to Man9-V3 and aglycone V3 peptides. Donor plasma was screened in duplicate assays, and binding is represented as mean values. (B) Memory B cells from donor CH765 were decorated with either fluorophore-conjugated BG505.T332N.SOSIP and DU156.12.SOSIP in phycoerythrin (PE) and allophycocyanin (APC), or Man9-V3 tetramers tagged to SA-AF647 (Alexa Fluor 647) and SA-BV421 (Brilliant Violet 421). The B cells from which CH765-VRC41.01, VRC41.02, and DH563 were cloned are indicated as green, red, and blue dots, respectively. (C) Immunogenetics and phylogeny of the DH563-VRC41 clonal lineage were inferred using Clonanalyst (33, 34). See also fig. S3. nt, nucleotide. (D) Reactivity of CH765-VRC41.01, CH765-VRC41.02, and DH563 to Man5, Man6, Man7-D1, Man7-D3, Man8-D1D3, and Man9 glycans, ...
https://stm.sciencemag.org/content/9/381/eaai7521/tab-figures-data
GlycoFish - omicXGlycoFish - omicX
A mass spectrometry-based glycoproteomic characterization of zebrafish embryos was performed to identify the N-linked glycoproteins and N-linked glycosylation sites. To increase the number of glycopeptides, proteins from zebrafish were digested with two different proteases--chymotrypsin and trypsin--into peptides of different length. The N-glycosylated peptides of zebrafish were then captured by the solid-phase extraction of N-linked glycopeptides (SPEG) method and the peptides were identified with an LTQ OrbiTrap Velos mass spectrometer.
https://omictools.com/glycofish-tool
ACQUITY UPLC Glycoprotein BEH Amide VanGuard Pre-column, 300Å, 1.7 µm, 2.1 mm X 5 mm, 3/pk with Glycoprotein Performance Test...ACQUITY UPLC Glycoprotein BEH Amide VanGuard Pre-column, 300Å, 1.7 µm, 2.1 mm X 5 mm, 3/pk with Glycoprotein Performance Test...
Waters Glycoprotein BEH Amide 300A, 1.7um columns were primarily designed for the analysis of intact glycoproteins, glycoprotein fragments, and glycopeptides.. Each batch of Glycoprotein BEH Amide 300A 1.7um material is specifically quality control tested with the Waters Glycoprotein Performance Test Standard (P/N 86008010 that includes a mixture of Ribonuclease A as well as Ribonulease B glycoforms) to help ensure batch to batch consistency. This kit includes one Glycoprotein BEH Amide 300A, 1.7um column and one vial of Waters Glycoprotein Performance Test Standard. The standard is included to be able to immediately benchmark the column upon receipt and can be reordered as a separate part for continued monitoring. Each batch of digestion standard is prepared under strict quality control criteria confirmed on the included certificate of analysis.
https://www.waters.com/nextgen/kr/ko/shop/columns/176003699-acquity-uplc-glycoprotein-beh-amide-vanguard-pre-column-300a-17-.html?locale=en_US
ACQUITY UPLC Glycoprotein BEH Amide VanGuard Pre-column, 300Å, 1.7 µm, 2.1 mm X 5 mm, 3/pk with Glycoprotein Performance Test...ACQUITY UPLC Glycoprotein BEH Amide VanGuard Pre-column, 300Å, 1.7 µm, 2.1 mm X 5 mm, 3/pk with Glycoprotein Performance Test...
Waters Glycoprotein BEH Amide 300A, 1.7um columns were primarily designed for the analysis of intact glycoproteins, glycoprotein fragments, and glycopeptides.. Each batch of Glycoprotein BEH Amide 300A 1.7um material is specifically quality control tested with the Waters Glycoprotein Performance Test Standard (P/N 86008010 that includes a mixture of Ribonuclease A as well as Ribonulease B glycoforms) to help ensure batch to batch consistency. This kit includes one Glycoprotein BEH Amide 300A, 1.7um column and one vial of Waters Glycoprotein Performance Test Standard. The standard is included to be able to immediately benchmark the column upon receipt and can be reordered as a separate part for continued monitoring. Each batch of digestion standard is prepared under strict quality control criteria confirmed on the included certificate of analysis.
https://www.waters.com/nextgen/xg/fr/shop/columns/176003699-acquity-uplc-glycoprotein-beh-amide-vanguard-pre-column-300a-17-.html
Diagnosis of fatal chest pain with copeptin levels. | AbstractDiagnosis of fatal chest pain with copeptin levels. | Abstract
Chest pain is a clinical problem which often results in emergency department visits and is characterized by difficult differential diagnosis. Although..
https://www.alliedacademies.org/abstract/diagnosis-of-fatal-chest-pain-with-copeptin-levels-4534.html
New Dual Biomarker Test Could Speed Rule-Out of MI in the ED - CardioExchange CardioExchangeNew Dual Biomarker Test Could Speed Rule-Out of MI in the ED - CardioExchange CardioExchange
Only 1 in 10 patients with acute chest pain in the emergency department turn out to have an acute myocardial infarction, yet many are not released from the hospital until after 6 to 12 hours of cardiac monitoring and multiple ECG and troponin tests. The search for a test that can rule out MI early in the process has proved elusive.. The Biomarkers in Cardiology-8 (BIC-8) trial, presented at the European Society of Cardiology meeting in Amsterdam, was designed to determine the utility of the combination of troponin and copeptin testing. Copeptin is a marker of severe hemodynamic stress. After an acute MI, copeptin levels increase rapidly. In earlier observational studies, the combination test was found to have a negative predictive value of 99%.. Some 902 patients with suspected ACS who were troponin-negative were randomized to standard treatment or an experimental strategy in which those with a negative copeptin test were discharged early. At 30 days, there were no significant differences in the ...
https://blogs.jwatch.org/cardioexchange/2013/09/04/biomarker/
Conjugation of Glycopeptide Thioesters to Expressed Protein Fragments | Springer for Research & DevelopmentConjugation of Glycopeptide Thioesters to Expressed Protein Fragments | Springer for Research & Development
This method describes the conjugation of a synthetic glycopeptide to the N-terminus of a recombinant human interleukin-2 (IL-2) protein fragment. The IL-2 protein fragment is produced as an...
https://rd.springer.com/protocol/10.1385/1-59259-813-7%3A255
ALZFORUM | NETWORKING FOR A CUREALZFORUM | NETWORKING FOR A CURE
Nilsson J, Rüetschi U, Halim A, Hesse C, Carlsohn E, Brinkmalm G, Larson G. Enrichment of glycopeptides for glycan structure and attachment site identification ...
http://www.alzforum.org/papers/enrichment-glycopeptides-glycan-structure-and-attachment-site-identification
Bachem - Bachem AG and GlyTech, Inc. announce co-promotion agreementBachem - Bachem AG and GlyTech, Inc. announce co-promotion agreement
Bubendorf/Basel, October 7, 2014 - Bachem the leading peptide manufacturer, and GlyTech Inc. (Kyoto, Japan), the world-leading developer of glycosylated drugs, announced today that they have entered into a co-promotion agreement for GlyTechs glycosylation technology. As part of the agreement, Bachem will leverage its sales and marketing resources to enhance GlyTechs partnering efforts and GlyTech will promote Bachem as the partner of choice for manufacture of its glycopeptides and glycoproteins. Press release. ...
http://www.bachem.com/news-media/press-releases/detail/article/bachem-ag-and-glytech-inc-announce-co-promotion-agreement/
The antibody sticks and recognises to a cell-surface receptor.The antibody sticks and recognises to a cell-surface receptor.
Cancers Vaccine - Synthetically generated glycopeptides from tumor cells may stimulate the formation of specific antibodies Tumor cells and healthy somatic cells differ in the structures on their surfaces. Because these distinctions between surface area antigens are minimal frequently, all initiatives in this direction have far failed thus; it is not feasible to elicit a targeted immune response directed specifically against the tumor cells. A united group of researchers headed by Horst Kunz in Mainz, Germany, has now come a step further. They have successfully developed a artificial vaccine that induces a solid and particular immune response against the desired tumor antigen in mice.. ...
http://northendbikes.com/2017/09/03/the-antibody-sticks-and-recognises-to-a-cell-surface-receptor/
FDA Grants QIDP Designation to The Medicines Companys Investigational Antibiotic Oritavancin
The Medicines Company (NASDAQ: MDCO) today announced that the U.S. Food and Drug Administration (FDA) has designated oritavancin as a Qualified Infectious Disease Product (QIDP)
http://www.andhranews.net/Business/2013/FDA-Grants-QIDP-Designation-Medicines-Companys-46793.htm
Publications | Research | Materials Research Science and Engineering Center | Brandeis UniversityPublications | Research | Materials Research Science and Engineering Center | Brandeis University
Dr. Blanc is a postdoc supervised by Fraden. Blancs role on this IRG1 project was calculation of the liquid crystalline phase behavior. This work was partially supported by the MRSEC). Zhou, J., Du, X., Chen, X. and Xu, B., Adaptive Multifunctional Supramolecular Assemblies of Glycopeptides Rapidly Enable Morphogenesis, Biochemistry 57, 4867-4879 (2018) doi: 10.1021/acs.biochem.8b00125.. Feng, Z., Wang, H., Wang, S., Zhang, Q., Zhang, X., Rodal, A. A. and Xu, B., Enzymatic Assemblies Disrupt the Membrane and Target Endoplasmic Reticulum for Selective Cancer Cell Death, J Am Chem Soc 140, 9566-9573 (2018) doi: 10.1021/jacs.8b04641.. Lazaro, G. R., Dragnea, B. and Hagan, M. F., Self-assembly of convex particles on spherocylindrical surfaces, Soft Matter 14, 5728-5740 (2018) doi: 10.1039/c8sm00129d.. Zeng, C, Rodriguez Lazaro, G, Tsvetkova, IB, Hagan, MF, & Dragnea, B. Defects and Chirality in the Nanoparticle-Directed Assembly of Spherocylindrical Shells of Virus Coat Proteins. ACS Nano, ...
https://www.brandeis.edu/mrsec/research/publications.html
galectin 1 Protocols and Video...galectin 1 Protocols and Video...
Video articles in JoVE about galectin 1 include Isolation and Characterization Of Chimeric Human Fc-expressing Proteins Using Protein A Membrane Adsorbers And A Streamlined Workflow, Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells, Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve, Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry.
https://www.jove.com/keyword/galectin+1
Antibacterial activity of the new glycopeptide antibiotic SKF104662<...Antibacterial activity of the new glycopeptide antibiotic SKF104662<...
TY - JOUR. T1 - Antibacterial activity of the new glycopeptide antibiotic SKF104662. AU - Jorgensen, J. H.. AU - Redding, J. S.. AU - Maher, L. A.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - The inhibitory activity of the new glycopeptide antibiotic SKF104662 was generally equivalent (±1 concentration increment) to the activities of vancomycin, teicoplanin, and daptomycin against selected gram-positive bacteria. However, SKF104662 demonstrated greater activity against Staphylococcus epidermidis and S. haemolyticus than did teicoplanin and was more active than the other drugs against Clostridium difficile isolates. SKF104662 possessed bactericidal activity quite similar to that of vancomycin against selected isolates of Staphylococcus, Streptococcus, and Enterococcus species.. AB - The inhibitory activity of the new glycopeptide antibiotic SKF104662 was generally equivalent (±1 concentration increment) to the activities of vancomycin, teicoplanin, and daptomycin against selected gram-positive bacteria. ...
https://scholars.uthscsa.edu/en/publications/antibacterial-activity-of-the-new-glycopeptide-antibiotic-skf1046
Copeptin, a surrogate marker for arginine vasopressin secretion, is positively associated with glucagon - Forskning - Region...
Aim: To explore the association of plasma copeptin, the C-terminal portion of provasopressin and a stable surrogate marker for arginine vasopressin secretion, with plasma glucagon in obese men and men of normal weight. Methods: We measured fasting blood concentrations of copeptin and glucagon in 102 healthy obese men (mean ± sd age 49.4 ± 10.2 years) and a control group 27 healthy men of normal weight (mean ± sd age 51.5 ± 8.4 years). Differences between groups were evaluated using t-tests, and multiple linear regression analysis, adjusting for age and weight status (normal weight vs obese), was used to calculate unstandardized regression coefficients (β) with 95% CIs between copeptin and glucagon. Copeptin was (natural) log-transformed. Results: The obese men had higher [median (interquartile range)] plasma copeptin concentrations [6.6 (4.6-9.5) vs 4.9 (3.5-6.8) pmol/l; P = 0.040] and higher mean ± sd plasma glucagon concentrations (8.5 ± 3.8 vs 5.3 ± 1.4 pmol/l; P , 0.001) than the ...
https://research.regionh.dk/da/publications/copeptin-a-surrogate-marker-for-arginine-vasopressin-secretion-is-positively-associated-with-glucagon
Abstract 15186: High Level of Copeptin in ST Elevation Acute Myocardial Infarction Patients is Associated with In-Hospital...Abstract 15186: High Level of Copeptin in ST Elevation Acute Myocardial Infarction Patients is Associated with In-Hospital...
Background. Copeptin has been known to predict heart failure and cardiovascular death in patients with acute coronary syndrome.. Methods. We collected coronary arterial blood samples from the infarct artery during primary percutaneous coronary intervention (PCI) in 80 STEMI pts and 28 controls. We assessed commonly used cardiac biomarkers (CK, CK-MB, troponin-I, CRP) and additionally measured recently introduced biomarkers (Copeptin [C-terminal Provasopressin] and N-terminal pro-B-type natriuretic peptide [NT-proBNP]).. Results. Pt age was 58±12 yrs and 93% were males. Intravascular ultrasound (IVUS) of the culprit lesion in 67 pts showed ruptured plaques in 28 pts. STEMI pts had a higher Copeptin level (265.89±183.11 pmol/L) vs193.67±60.16 pmol/L in normal controls, p=0.005. Especially, Copeptin levels were higher in ruptured plaque compared to non-ruptured plaques: 318.83±209.34 pmol/L vs 221.99±151.49 pmol/L, p=0.034. While troponin I, CK-MB, and CRP were not correlated with Copeptin, ...
http://circ.ahajournals.org/content/126/Suppl_21/A15186
Copeptin Release in Cardiac Surgery-A New Biomarker to Identify Risk Patients?Copeptin Release in Cardiac Surgery-A New Biomarker to Identify Risk Patients?
Regardless of cardiac surgical procedure and perioperative course, all patients had an early significant rise of copeptin concentrations, generally peaking at weaning from CBP or upon arrival in the intensive care unit. Among patients with normal copeptin concentration preoperatively and uneventful …
https://pubmed.ncbi.nlm.nih.gov/29102258/
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute...Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute...
The median concentration of copeptin at admission was lower in AECOPD compared to acute HF (8.8 [5.2-19.7] vs. 22.2 [10.2-47.9]) pmol/L, p < 0.001), but NT-proBNP discriminated acute HF from non-HF related dyspnea more accurately than copeptin (ROC-AUC 0.85 [0.81-0.89] vs. 0.71 [0.66-0.77], p < 0.0001). Adjusted for basic risk factors, increased copeptin concentrations predicted mortality in AECOPD (HR per log (ln) unit 1.72 [95% CI 1.21-2.45], p = 0.003) and acute HF (1.61 [1.25-2.09], p < 0.001), whereas NT-proBNP concentrations predicted mortality only in acute HF (1.62 [1.27-2.06], p < 0.001). On top of a basic model copeptin reclassified a significant proportion of patients into a more accurate risk strata in AECOPD (NRI 0.60 [0.19-1.02], p = 0.004) and acute HF (0.39 [0.06-0.71], p = 0.020). CONCLUSION ...
https://www.physiciansweekly.com/prognostic-and-diagnostic-significance-of-copeptin-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-and-acute-heart-failure-data-from-the-ace-2-study-2/
Vicia graminea - EY Laboratories, Inc.Vicia graminea - EY Laboratories, Inc.
Crude extracts of Vicia graminea seeds contain an agglutinin that is blood group N specific. The lectin exhibits a complex carbohydrate specificity. It is not inhibited by any mono- or disaccharides, although the O-linked blood group N antigen is a disaccharide with the structure Gal β(1,3)GalNAc. This carbohydrate structure is also recognized by the peanut lectin, but PNA binds to other galactose containing glycoconjugates as well. The peptide portion of the blood group N antigen is critical for binding of VGA. The extended binding site of the lectin reacts with clusters of O-linked Gal β(1,3)GalNAc adjacent to an N-terminal leucine residue 1,2 . Disaccharide clusters located on the first eight amino acids of O-linked glycopeptides react more strongly than these same clusters located on other amino acid residues 2 . VGA will bind to glycoproteins containing sialic acid, but removal of terminal sialic acid residues from these glycoproteins increases the reactivity of VGA. Both VGA and PNA can ...
http://eylabs.com/vicia-graminea/
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.. The study of protein glycosylation has lagged far behind the progress of current proteomics because of the enormous complexity, wide dynamic range distribution and low stoichiometric modification of glycoprotein. Solid phase extraction of tryptic N-glycopeptides by hydrazide chemistry is becoming a popular protocol for the analysis of N-glycoproteome. However, in silico digestion of proteins in human proteome database by trypsin indicates that a significant percentage of tryptic N-glycopeptides is not in the preferred detection mass range of shotgun proteomics approach, that is, from 800 to 3500 Da. And the quite big size of glycan groups may block trypsin to access the K, R residues near N-glycosites for digestion, which will result in generation of big glycopeptides. Thus many N-glycosites could not be localized if only trypsin was used to digest proteins. Herein, we describe a comprehensive way to analyze the N-glycoproteome ...
http://www.uniprot.org/citations/19159218
Research highlight - Analytics of Biomolecular Interactions - Amsterdam Institute for Molecules, Medicines and Systems (AIMMS),...Research highlight - Analytics of Biomolecular Interactions - Amsterdam Institute for Molecules, Medicines and Systems (AIMMS),...
Kathrin Stavenhagen: Glycopeptide analysis remains challenging because of its sample heterogeneity resulting from the degree of glycosylation site occupancy (macroheterogeneity) and the different glycoforms attached to individual glycosylation sites (microheterogeneity).. With respect to the latter one, qualitative site-specific glycosylation information of glycoproteins can be obtained by unspecific protease treatment resulting in small amino acid stretches carrying the glycan. This improves determination of the glycosylation sites. However, detecting these glycopeptides by 1D-LC-ESI-MS/MS is challenging due to insufficient or irreversible retention on the stationary phase and thus multiple analyses with different LC-setups are required. Since biological sample amounts are usually limited, methods for acquiring comprehensive information in a single run are necessary.. To obtain qualitative information of the glycosylation site we set up an integrated C18-porous graphitized carbon ...
https://aimms.vu.nl/en/research/research-groups/analytics-of-biomolecular-interactions/research-highlight/index.aspx
Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies | Science Translational MedicineStaged induction of HIV-1 glycan-dependent broadly neutralizing antibodies | Science Translational Medicine
Although it typically evades the immune system, HIV does have sites of vulnerability that can be targeted in vaccine design. One such site is a glycan near the V3 loop of the envelope protein, but antibodies recognizing this epitope are often not detected in people infected with HIV. Alam et al. designed a synthetic glycopeptide that can identify B cells targeting this epitope and also used it to immunize macaques. Bonsignori et al. used this synthetic glycopeptide and other baits to study the V3-glycan antibody responses of an HIV-infected individual that developed broadly neutralizing antibodies. They also examined viral evolution over time and found clues as to why these types of antibodies do not develop more often. These tools and findings could pave the way for a vaccine that protects against diverse strains of HIV. ...
http://stm.sciencemag.org/content/9/381/eaai7514.editor-summary
Glycopeptides | Profiles RNS
Kailemia MJ, Wei W, Nguyen K, Beals E, Sawrey-Kubicek L, Rhodes C, Zhu C, Sacchi R, Zivkovic AM, Lebrilla CB. Targeted Measurements of O- and N-Glycopeptides Show That Proteins in High Density Lipoprotein Particles Are Enriched with Specific Glycosylation Compared to Plasma. J Proteome Res. 2018 02 02; 17(2):834-845 ...
https://profiles.uchicago.edu/profiles/display/16165
APAC, Europe, America region to generate massive revenues for Glycopeptide Antibiotics market by 2026APAC, Europe, America region to generate massive revenues for Glycopeptide Antibiotics market by 2026
Market Study Report, LLC, has recently added a report on the Glycopeptide Antibiotics market which presents substantial inputs about the market size, market share, regional trends, and profit projection of this business sphere
https://www.algosonline.com/news/glycopeptide-antibiotics-market-analysis-report
GlycoProtDB - Glycoprotein DatabaseGlycoProtDB - Glycoprotein Database
1) Kaji H, Saito H, Yamauchi Y, Shinkawa T, Taoka M, Hirabayashi J, Kasai K, Takahashi N, Isobe T. Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins. Nat Biotechnol. 2003 Jun;21(6):667-72. [PMID: 12754521]. 2) Kaji H, Yamauchi Y, Takahashi N, Isobe T. Mass spectrometric identification of N-linked glycopeptides using lectin-mediated affinity capture and glycosylation site-specific stable isotope tagging. Nat Protoc. 2006;1(6):3019-27. [PMID: 17406563]. 3) Shinkawa T, Taoka M, Yamauchi Y, Ichimura T, Kaji H, Takahashi N, Isobe T. STEM: a software tool for large-scale proteomic data analyses. J Proteome Res. 2005 Sep-Oct;4(5):1826-31. [PMID: 16212438]. 4) Kaji H, Kamiie J, Kawakami H, Kido K, Yamauchi Y, Shinkawa T, Taoka M, Takahashi N, Isobe T. Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins. Mol Cell Proteomics. 2007 Dec;6(12):2100-9. ...
https://acgg.asia/db/gpdb/index?doc_no=3
Copeptin Helps in the Early Detection of Patients With Acute Myocardial Infarction: The Primary Results of the CHOPIN Trial -...Copeptin Helps in the Early Detection of Patients With Acute Myocardial Infarction: The Primary Results of the CHOPIN Trial -...
AMI was the final diagnosis in 156 patients (7.9%). A negative copeptin and cTnI at baseline ruled out AMI for 58% of patients, with a negative predictive value (NPV) of 99.2%. AMIs not detected by the initial cTnI alone were picked up with copeptin >14 pmol/L in 23/32 patients (72%). Non−ST-segment elevation MIs (NSTEMIs) undetected by cTnI at 0 hours were detected with copeptin >14 pmol/L in 10/19 patients (53%). Projected average time-to-decision could be reduced by 43% (from 3.0 hours to 1.8 hours) by the early rule out of 58% of patients. Both abnormal copeptin and cTnI were predictors of death at 180 days (p < 0.0001 for both, c-index 0.784 and 0.800, respectively). Both were independent of age and each other and provided additional predictive value (p < 0.0001).. ...
http://www.acc.org/latest-in-cardiology/journal-scans/2013/05/08/16/26/copeptin-helps-in-the-early-detection-of-patients-with-acute-mi
Structural Analysis of Glycosylated Peptides in Complex Mixtures with ,,, Ion Trap MSn ( Structural Analysis of...Structural Analysis of Glycosylated Peptides in Complex Mixtures with ,,, Ion Trap MSn ( Structural Analysis of...
Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MS n Shiaw-Lin Wu Pavel Bondarenko Tom Shaler Paul Shieh and William S. Hancock Protein Glycosylation The data presented here can be acquired using a,Structural,Analysis,of,Glycosylated,Peptides,in,Complex,Mixtures,with,,,,,,,,,,,,Ion,Trap,MSn,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology
http://www.bio-medicine.org/biology-technology/Structural-Analysis-of-Glycosylated-Peptides-in-Complex-Mixtures-with--0D-0A-0A--------Ion-Trap-MSn-732-1/
Designer Glycopeptides for Cytotoxic T Cell-based Elimination of Carcinomas | Journal of Experimental Medicine | Rockefeller...Designer Glycopeptides for Cytotoxic T Cell-based Elimination of Carcinomas | Journal of Experimental Medicine | Rockefeller...
There is a very strong correlation between the affinity of peptide binding to MHC molecules and the capacity of the peptide to induce an immune response (31, 32). This information is critical to the strategy used in this study. The size of a peptide determines its capacity to bind class I MHC. Whereas the optimal peptide length for most murine MHC molecules appears to be 9-amino acid residues, the Kb and Kk molecules prefer 8-residue peptides (33). Kb molecules were initially chosen to define a glycopeptide that: (a) binds with high affinity; and (b) will be of a structure that skews the T cell response toward recognition of the carbohydrate moiety rather than toward either the peptide or the MHC molecule. The critical anchor residues for Kb binding have been canonically defined as phenylalanine (F) or tyrosine (Y) in position 5 and leucine (L) or methionine (M) at position 8 of an octamer peptide (8). The maintenance of critical hydrogen bonding between main chain atoms in the peptide and atoms ...
https://rupress.org/jem/article/199/5/707/40046/Designer-Glycopeptides-for-Cytotoxic-T-Cellbased
Glycan and Glycopeptide Analysis | Mass Spectra Interpretation | Post Translational ModificationGlycan and Glycopeptide Analysis | Mass Spectra Interpretation | Post Translational Modification
Perform Glycan and Glycopeptide Qualitative Analysis, Glycan Structure Prediction & Multi stage Mass Spectrometry (MSn) data analysis using accurate ranking mechanism.
http://premierbiosoft.com/glycan/index.html
Methods For The Analysis Of Glycoproteins Or Glycopeptides By Mass Spectrometry | 360BIOMethods For The Analysis Of Glycoproteins Or Glycopeptides By Mass Spectrometry | 360BIO
The leading news and search platform for precision medicine and medical diagnostics. From biomarkers to genetic testing and molecular diagnostics, a comprehensive review of up-to-date information required by researchers and physicians.
http://360.bio/patents/US9255906/methods-analysis-glycoproteins-glycopeptides-mass-spectrometry/
Semisynthesis of a homogeneous glycoprotein enzyme : ribonuclease C: part 1 - ERef BayreuthSemisynthesis of a homogeneous glycoprotein enzyme : ribonuclease C: part 1 - ERef Bayreuth
Seven in one blow: The efficient formation of mixed disulfides on the thiol-rich fusion protein A followed by subsequent intein cleavage gave the fragment B with all seven cysteines protected against oxidation. The native chemical ligation of B with synthetic glycopeptide thioesters provides glycoproteins ...
https://eref.uni-bayreuth.de/14573/
February | 2014 | Life-Sciences
FDA Accepts Filing of NDA for IV Antibiotic Oritavancin with Priority Review Oritavancin ( INN, also known as LY333328) is a novel semi-synthetic glycopeptide antibiotic being developed for the treatment of serious Gram-positive infections. Originally discovered and developed by Eli Lilly, oritavancin was acquired by InterMune in 2001 and then by Targanta Therapeutics in late 2005. In Dec 2008 the FDA declined to approve […]. ...
http://life-sciences.blognotions.com/2014/02/
Umesh Laddi | Life-Sciences
FDA Accepts Filing of NDA for IV Antibiotic Oritavancin with Priority Review Oritavancin ( INN, also known as LY333328) is a novel semi-synthetic glycopeptide antibiotic being developed for the treatment of serious Gram-positive infections. Originally discovered and developed by Eli Lilly, oritavancin was acquired by InterMune in 2001 and then by Targanta Therapeutics in late 2005. In Dec 2008 the FDA declined to approve […]. ...
http://life-sciences.blognotions.com/author/uladdi/page/2/
Structure Cluster - 1GAC: NMR structure of asymmetric homodimer of a82846b, a glycopeptide antibiotic, complexed with...Structure Cluster - 1GAC: NMR structure of asymmetric homodimer of a82846b, a glycopeptide antibiotic, complexed with...
1GAC: Conformation of A82846B, a Glycopeptide Antibiotic, Complexed with its Cell Wall Fragment: An Asymmetric Homodimer Determined Using NMR Spectroscopy.
http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1GAC
Plus itPlus it
An estimate of the relative abundance of the various O-glycans was determined from nanoLC-ESI-IT-MS analysis of trypsin-generated (glyco)peptides. It should be noted that because the signal of the monosialylated O-glycopeptide in triply charged state overlapped with the doubly charged peak of the hinge repeat peptide with a putative acetylation modification in all samples, only the doubly charged signal of the monosialylated O-glycopeptide was quantified, thereby leading to an underestimation of this O-glycoform. Furthermore, it is known that glycopeptides with different glycan structures can have different response factors (35), and thus the relative abundances we measured may not accurately reflect the real ratios. In order to obtain a more reliable estimate of the percentage of the hinge repeat motif bearing an O-glycan, tryptic IgG peptides were incubated with exoglycosidases, trimming all O-glycans down to a single N-acetylhexosamine. A previous study of quantitative measurements of a ...
https://www.mcponline.org/content/14/5/1373
Publications | Max Planck Institute of Colloids and Interfaces
Danishefsky, S. J.; Hu, S.; Cirillo, P. F.; Eckhardt, M.; Seeberger, P. H.: A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a natural peptide motif. Chemistry - A European Journal 3 (10), pp. 1617 - 1628 (1997 ...
https://www.mpikg.mpg.de/publication-search/6345166?page=26&person=%2Fpersons%2Fresource%2Fpersons121849
Ciencias de la vida: instrumentos analíticos para la investigación proteómica y metabolómica - Applications - Life Science and...Ciencias de la vida: instrumentos analíticos para la investigación proteómica y metabolómica - Applications - Life Science and...
Despite a known biological importance, the glycoconjugate complexity has been an obstacle to their systematic analysis. Bruker is now delivering the tools to successfully address the challenges of glyco analysis. This includes glycopeptides, glycans, and glycoproteins and thus supports all common strategies.. Glyco Analysis ...
https://www.bruker.com/es/applications/life-sciences.html
Publications | Max Planck Institute of Colloids and Interfaces
Stavenhagen, K.; Hinneburg, H.; Thaysen-Andersen, M.; Hartmann, L.; Varón Silva, D.; Fuchser, J.; Kaspar, S.; Rapp, E.; Seeberger, P. H.; Kolarich, D.: Quantitative mapping of glycoprotein micro-heterogeneity and macro-heterogeneity: an evaluation of mass spectrometry signal strengths using synthetic peptides and glycopeptides. Journal of Mass Spectrometry 48 (6), pp. 627 - 639 (2013 ...
https://www.mpikg.mpg.de/publication-search/5205161?person=%2Fpersons%2Fresource%2Fpersons121390
TeicoplaninTeicoplanin
Teicoplanin Teicoplanin Systematic (IUPAC) name  ? Identifiers CAS number 61036-62-2 ATC code J01XA02 PubChem  ? Chemical data Formula Variable Mol.
https://www.chemeurope.com/en/encyclopedia/Teicoplanin.html
Ovarian disorders - Oxford MedicineOvarian disorders - Oxford Medicine
The ovary produces (1) gametes-germ cells in the ovary have undergone the first meiotic division to become oocytes in primordial follicles by the time of birth, with about 400 of these ovulating during reproductive life; and (2) hormones-oestradiol, progesterone, androgens, and two nonsteroidal glycopeptides, inhibin A and B....
http://oxfordmedicine.com/view/10.1093/med/9780199204854.001.1/med-9780199204854-chapter-130801
Copeptin predicts prognosis in HF patientsCopeptin predicts prognosis in HF patients
Copeptin predicts prognosis in patients with heart failure, according to research presented at the ESC Congress today, August 25, by Professor Stefan Störk from Germany.
https://medicalxpress.com/news/2012-08-copeptin-prognosis-hf-patients.html
ChemIDplus - 192126-76-4 - MQBCDKMPXVYCGO-FQBKTPCVSA-N - Mycothiol - Similar structures search, synonyms, formulas, resource...
192126-76-4 - MQBCDKMPXVYCGO-FQBKTPCVSA-N - Mycothiol - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/192126-76-4
Biochem 3A03 & 3R06 Projects Completed! - McArthur Lab
Tammy Lau - The Importance of Protocol Design for RNA-Seq in the Ongoing Development of a Novel Technology for Tissue Specific Gene Expression Profiling in C. elegans. Arjun Sharma - The Glycopeptide Resistance Predictor. ...
http://mcarthurbioinformatics.ca/?p=872
GlycopeptideGlycopeptide
The glycopeptides are produced by spotting FMOC protected amino acids allowing the synthesis to be performed at microgram ( ... Glycopeptides are peptides that contain carbohydrate moieties (glycans) covalently attached to the side chains of the amino ... The synthesis of glycopeptides provides biological probes for researchers to elucidate glycan function in nature and products ... In this method, libraries of glycopeptides are produced on a cellulose surface (e.g. filter paper) which acts as the solid ...
https://en.wikipedia.org/wiki/Glycopeptide
Mannopeptimycin glycopeptideMannopeptimycin glycopeptide
... is a lead antibiotic peptide. Sum, Phaik-Eng; How, David; Torres, Nancy; Petersen, Peter J.; Lenoy ... "Novel ether derivatives of mannopeptimycin glycopeptide antibiotic". Bioorganic & Medicinal Chemistry Letters. 13 (6): 1151- ...
https://en.wikipedia.org/wiki/Mannopeptimycin_glycopeptide
Glycopeptide antibioticGlycopeptide antibiotic
Ramoplanin, although a "glycopeptide" in the literal sense, has a quite different structural core. It not only binds to Lipid ... Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic ... Glycopeptides have typically been considered the last effective line of defense for cases of MRSA, however several newer ... The second-generation glycopeptides, or "lipoglycopeptides", have better binding to Lipid II due to the lipophilic moieties, ...
https://en.wikipedia.org/wiki/Glycopeptide_antibiotic
Glycopeptide alpha-N-acetylgalactosaminidaseGlycopeptide alpha-N-acetylgalactosaminidase
Glycopeptide α-N-acetylgalactosaminidases belong to family GH101 of glycoside hydrolases. Ashida H, Maki R, Ozawa H, Tani Y, ... is an enzyme with systematic name glycopeptide-D-galactosyl-N-acetyl-α-D-galactosamine D-galactosyl-N-acetyl- ...
https://en.wikipedia.org/wiki/Glycopeptide_alpha-N-acetylgalactosaminidase
B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferaseB-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
... is a galactosyltransferase. It is classified under EC 2.4.1.38 ...
https://en.wikipedia.org/wiki/B-N-acetylglucosaminyl-glycopeptide_b-1,4-galactosyltransferase
Streptomyces candidusStreptomyces candidus
1994). Glycopeptide antibiotics. New York u.a.: Dekker. ISBN 0-8247-9193-2. Wagman, edited by Gerald H.; Cooper, Raymond (1989 ...
https://en.wikipedia.org/wiki/Streptomyces_candidus
KibdelosporangiumKibdelosporangium
Nagarajan, Ramakris (1994). Glycopeptide Antibiotics. CRC Press. ISBN 9780824791933. Mukherjee, Joydeep (2014). ...
https://en.wikipedia.org/wiki/Kibdelosporangium
Ototoxic medicationOtotoxic medication
Glycopeptides are another class of antibiotics. Vancomycin is the class originator for the glycopeptides. Lipoglycopeptides are ... Glycopeptides, on the other hand, are rarely associated with ototoxicity. Aminoglycosides are a class of antibiotics. The most ... The most common classes of ototoxic medications include antibiotics (including aminoglycosides and glycopeptides) and ... a subclass of glycopeptides and they are derived from the structure of vancomycin. Examples are telavancin and dalbavancin. ...
https://en.wikipedia.org/wiki/Ototoxic_medication
VancomycinVancomycin
... is a glycopeptide antibiotic medication used to treat a number of bacterial infections. It is recommended ... It is a type of glycopeptide antibiotic and works by blocking the construction of a cell wall. Vancomycin was approved for ... These P450s are recruited by the X domain present in the 7th NRPS module, which is unique to glycopeptide antibiotic ... Glycopeptide-Intermediate Staphylococcus aureus Working Group". The New England Journal of Medicine. 340 (7): 493-501. doi: ...
https://en.wikipedia.org/wiki/Vancomycin
Glycosidic bondGlycosidic bond
O-linked glycopeptides recently have been shown to exhibit excellent CNS permeability and efficacy in multiple animal models ... The peculiar nature of O-linked glycopeptides is that there are numerous examples which are CNS penetrant. The fundamental ... "Biousian glycopeptides penetrate the blood-brain barrier". Tetrahedron: Asymmetry. Carbohydrate Science. Part 1. 16 (1): 65-75 ...
https://en.wikipedia.org/wiki/Glycosidic_bond
PiperacillinPiperacillin
... glycopeptides, bacitracin, and fosfomycin.". In Giguère S, Prescott JF, Dowling PM (eds.). Antimicrobial Therapy in Veterinary ...
https://en.wikipedia.org/wiki/Piperacillin
CorbomycinCorbomycin
Ordinary glycopeptides instead block cell wall formation. It can block infections caused by the drug-resistant strain of ... Corbomycin is a member of the glycopeptide family of antibiotics that are produced by soil bacteria. Corbomycin blocks ... v t e (Articles with short description, Short description matches Wikidata, Use mdy dates from February 2020, Glycopeptide ... Researchers found the substance while studying the biosynthetic genes of glycopeptides that lacked self-resistance mechanisms. ...
https://en.wikipedia.org/wiki/Corbomycin
AvidinAvidin
Bruch RC, White HB (October 1982). "Compositional and structural heterogeneity of avidin glycopeptides". Biochemistry. 21 (21 ...
https://en.wikipedia.org/wiki/Avidin
TeicoplaninTeicoplanin
Thirty-five of these ORFs are similar to those found in other glycopeptide gene clusters. The function of each of these genes ... It is a semisynthetic glycopeptide antibiotic with a spectrum of activity similar to vancomycin. Its mechanism of action is to ... Heydorn A, Petersen BO, Duus JO, Bergmann S, Suhr-Jessen T, Nielsen J (March 2000). "Biosynthetic studies of the glycopeptide ... Peschke M, Brieke C, Cryle MJ (October 2016). "F-O-G Ring Formation in Glycopeptide Antibiotic Biosynthesis is Catalysed by ...
https://en.wikipedia.org/wiki/Teicoplanin
LipoglycopeptideLipoglycopeptide
... s are a class of antibiotic that have lipophilic side-chains linked to glycopeptides. The class includes ... Van Bambeke F. (August 2006). "Glycopeptides and glycodepsipeptides in clinical development: a comparative review of their ... Telavancin#Mechanism of action Kahne, Dan; Leimkuhler, Catherine; Lu, Wei; Walsh, Christopher (2005). "Glycopeptide and ...
https://en.wikipedia.org/wiki/Lipoglycopeptide
Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidasePeptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase
The systematic name of this enzyme class is N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase. ... Plummer TH, Tarentino AL (Oct 1981). "Facile cleavage of complex oligosaccharides from glycopeptides by almond emulsin peptide ... Takahashi N (Jun 1977). "Demonstration of a new amidase acting on glycopeptides". Biochemical and Biophysical Research ... Other names in common use include: glycopeptide N-glycosidase, glycopeptidase, N-oligosaccharide glycopeptidase, N-glycanase, ...
https://en.wikipedia.org/wiki/Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine_amidase
ProteoglycanProteoglycan
"Nomenclature of glycoproteins, glycopeptides and peptidoglycans, Recommendations 1985". www.qmul.ac.uk. Retrieved 16 March 2021 ...
https://en.wikipedia.org/wiki/Proteoglycan
GlycoproteinGlycoprotein
"Nomenclature of glycoproteins, glycopeptides and peptidoglycans, Recommendations 1985". www.qmul.ac.uk. Retrieved 16 March 2021 ... Ero1 Female sperm storage Glycocalyx Glycome Glycopeptide Gp120 Gp41 Miraculin P-glycoprotein Proteoglycan Ribophorin Glycan ... February 2011). "Cysteine S-glycosylation, a new post-translational modification found in glycopeptide bacteriocins". FEBS ...
https://en.wikipedia.org/wiki/Glycoprotein
Kerry LaPlanteKerry LaPlante
In year 2006, LaPlante focused her study on a glycopeptide antibiotic "Oritavancin", its development, usage and efficacy in ... Ward, Kristina E; Mersfelder, Tracey L; LaPlante, Kerry L (April 2006). "Oritavancin - an investigational glycopeptide ...
https://en.wikipedia.org/wiki/Kerry_LaPlante
Streptococcus dysgalactiaeStreptococcus dysgalactiae
... is uniformly susceptible to glycopeptides and oxazolidones. Diernhofer first used the name ...
https://en.wikipedia.org/wiki/Streptococcus_dysgalactiae
GlycosideGlycoside
... glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides.[citation needed] Much of the chemistry of glycosides is ...
https://en.wikipedia.org/wiki/Glycoside
Carbohydrate Structure DatabaseCarbohydrate Structure Database
Walsh I.; Zhao S.; Campbell M.; Taron C.H.; Rudd P.M. (2016). "Quantitative profiling of glycans and glycopeptides: an ...
https://en.wikipedia.org/wiki/Carbohydrate_Structure_Database
DihydroxyphenylglycineDihydroxyphenylglycine
DHGP is also found in vancomycin and related glycopeptides. Although the (S) stereoisomer is synthesized by the DpgA-D enzymes ... Chen, H., Tseng, C. C., Hubbard, B. K., Walsh, C. T. "Glycopeptide antibiotic biosyntehsis: Enzymatic assembly of the dedicated ... Yim, G., Thaker, M. N., Koteva, K., Wright, G. "Glycopeptide antibiotic biosynthesis." The Journal of Antibiotics, 2017, 67, 31 ... "A Polyketide Synthase in glycopeptide Biosynthesis: the Biosynthesis of the Non-Proteogenic Amino Acid (S)-3,5- ...
https://en.wikipedia.org/wiki/Dihydroxyphenylglycine
DirithromycinDirithromycin
... is a macrolide glycopeptide antibiotic. Dirithromycin (Dynabac) is a more lipid-soluble prodrug derivative of 9S- ...
https://en.wikipedia.org/wiki/Dirithromycin
Antarctic silverfishAntarctic silverfish
This Antarctic marine fish is one of several in the region that produce antifreeze glycopeptides as an adaptation against the ... A. P. Wohrmann (1995). "Antifreeze glycopeptides in the high-Antarctic Silverfish Pleurogramma antarcticum (Notothenioidei)". ...
https://en.wikipedia.org/wiki/Antarctic_silverfish
ST6GALNAC1ST6GALNAC1
June 2020). "Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries". Cell Chemical Biology. 27 (9): 1207-1219.e9. doi:10.1016 ...
https://en.wikipedia.org/wiki/ST6GALNAC1
D-alanine-(R)-lactate ligaseD-alanine-(R)-lactate ligase
Perichon B, Reynolds P, Courvalin P (September 1997). "VanD-type glycopeptide-resistant Enterococcus faecium BM4339". ...
https://en.wikipedia.org/wiki/D-alanine—(R)-lactate_ligase
O-GlcNAcO-GlcNAc
Using a bait glycopeptide based roughly on a consensus sequence for O-GlcNAc, α-enolase, EBP1, and 14-3-3 were identified as ... Teo, CF; Ingale, S; Wolfert, MA; Elsayed, GA; Nöt, LG; Chatham, JC; Wells, L; Boons, GJ (May 2010). "Glycopeptide-specific ... Directed tandem MS and targeted glycopeptide assignment allow for identification of O-GlcNAcylated peptide sequences. One ... recoded glycopeptides from beads using mild acid Obtain a full-scan mass spectrum from isotopically recoded glycopeptides Apply ...
https://en.wikipedia.org/wiki/O-GlcNAc
LantibioticsLantibiotics
Sublancin may be an S-linked glycopeptide). They are synthesised with a leader polypeptide sequence that is removed only during ... "Sublancin is not a lantibiotic but an S-linked glycopeptide". Nat. Chem. Biol. 7 (2): 78-80. doi:10.1038/nchembio.509. PMC ...
https://en.wikipedia.org/wiki/Lantibiotics
LinezolidLinezolid
Pigrau C, Almirante B (April 2009). "[Oxazolidinones, glycopeptides and cyclic lipopeptides]" [Oxazolidinones, glycopeptides ... A large meta-analysis of randomized controlled trials found linezolid to be more effective than glycopeptide antibiotics (such ... Falagas ME, Siempos II, Vardakas KZ (January 2008). "Linezolid versus glycopeptide or beta-lactam for treatment of Gram- ... Linezolid's spectrum of activity against Gram-positive bacteria is similar to that of the glycopeptide antibiotic vancomycin, ...
https://en.wikipedia.org/wiki/Linezolid
Laboratory Detection of Coagulase-negative Staphylococcus species with Decreased Susceptibility to the Glycopeptides Vancomycin...Laboratory Detection of Coagulase-negative Staphylococcus species with Decreased Susceptibility to the Glycopeptides Vancomycin...
What CoNS species with decreased susceptibility to glycopeptides have been reported? Isolates of S. haemolyticus and S. ... The term glycopeptide refers to a group of antimicrobial agents that includes vancomycin, teicoplanin, and several other ... Why is the term "glycopeptide" used, instead of vancomycin, to describe the decreased susceptibility of these CoNS isolates? ... Because of its broader scope, the term glycopeptide is used instead of vancomycin to describe these isolates. CoNS isolates ...
https://www.cdc.gov/hai/settings/lab/labdetectioncoagulase_negative.html
Retropharyngeal Abscess Medication: Antibiotics, Cephalosporins, 3rd Generation, Nitroimidazoles, Fluoroquinolones, Antibiotics...Retropharyngeal Abscess Medication: Antibiotics, Cephalosporins, 3rd Generation, Nitroimidazoles, Fluoroquinolones, Antibiotics...
Inhibits cell-wall biosynthesis; blocks glycopeptide polymerization by binding tightly to D-alanyl-D-alanine portion of cell ...
https://www.medscape.com/answers/764421-201163/which-medications-in-the-drug-class-glycopeptides-are-used-in-the-treatment-of-retropharyngeal-abscess
Figure - First Characterization of a Cluster of VanA-Type Glycopeptide-Resistant Enterococcus faecium, Colombia - Volume 8,...
First Characterization of a Cluster of VanA-Type Glycopeptide-Resistant Enterococcus faecium, Colombia Diana Panesso*, ... Pulsed-field gel electrophoresis restriction fragment patterns of SmaI-digested genomic DNA obtained from glycopeptide- ... First Characterization of a Cluster of VanA-Type Glycopeptide-Resistant Enterococcus faecium, Colombia. ...
https://wwwnc.cdc.gov/eid/content/8/9/961-f1.htm
Fractionation of sialylated oligosaccharides, glycopeptides, and glycoproteins on immobilized elderberry (Sambucus nigra L.)...Fractionation of sialylated oligosaccharides, glycopeptides, and glycoproteins on immobilized elderberry (Sambucus nigra L.)...
... glycopeptides, and glycoproteins on immobilized elderberry (Sambucus nigra L.) bark lectin ... Oligosaccharides, glycopeptides, or glycoproteins containing terminal Neu5Ac(alpha 2-6)Gal/GalNAc sequences bound to SNA- ... Furthermore, the SNA-Sepharose column was capable of resolving two oligosaccharides/glycopeptides based on the number of Neu5Ac ... Fractionation of sialylated oligosaccharides, glycopeptides, and glycoproteins on immobilized elderberry (Sambucus nigra L.) ...
https://eurekamag.com/research/040/168/040168543.php
Characterization of coagulase-negative staphylococcal isolates from blood with reduced susceptibility to glycopeptides and...Characterization of coagulase-negative staphylococcal isolates from blood with reduced susceptibility to glycopeptides and...
The aim of this study was to characterize CoNS with reduced susceptibility to glycopeptides causing blood stream infection (BSI ... Clinical review revealed that in 13 cases (7 in haematology and 6 in ICU), CoNS with reduced susceptibility to glycopeptides ... CoNS are usually multidrug-resistant and glycopeptide antibiotics have been to date considered the drugs of choice for ... Multi-resistant CoNS with reduced susceptibility to glycopeptides, although still relatively infrequent in our hospital, are ...
https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-9-83
RePub, Erasmus University Repository: A multi-center blinded study on the efficiency of phenotypic screening methods to...RePub, Erasmus University Repository: A multi-center blinded study on the efficiency of phenotypic screening methods to...
A multi-center blinded study on the efficiency of phenotypic screening methods to detect glycopeptide intermediately ... A multi-center blinded study on the efficiency of phenotypic screening methods to detect glycopeptide intermediately ...
https://repub.eur.nl/pub/36872
Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases | UBC...Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases | UBC...
The fluorescence-quenched glycopeptide N-gamma-{[}2-acetamido-6-(2-amino)benzamido-2,6-dideoxy-beta-D-glucopyr anosyl]-N-alpha ... Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases. ... Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases. ... Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases ...
https://www.chem.ubc.ca/convergent-synthesis-fluorescence-quenched-glycopeptide-potential-substrate-peptide-n-glycosidases
Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus.Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus.
Strains of Staphylococcus aureus with reduced susceptibility to glycopeptides have been reported from Japan, the United States ... Title : Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus. Personal Author(s) : Tenover, F. ... Many of the isolates with reduced susceptibility to glycopeptides have been associated with therapeutic failures with ...
https://stacks.cdc.gov/view/cdc/3314
Sulfated Glycoproteins, Glycolipids, and Glycosaminoglycans from Synaptic Plasma and Myelin Membranes: Isolation and...Sulfated Glycoproteins, Glycolipids, and Glycosaminoglycans from Synaptic Plasma and Myelin Membranes: Isolation and...
Isolation and Characterization of Sulfated Glycopeptides. Together they form a unique fingerprint. ...
https://experts.umn.edu/en/publications/sulfated-glycoproteins-glycolipids-and-glycosaminoglycans-from-sy/fingerprints/?sortBy=alphabetically
IMSEAR at SEARO: Glycopeptides-Important treatment option for methicillin-resistant Staphylococcus aureus.
Arora S, Arora U. Glycopeptides-Important treatment option for methicillin-resistant Staphylococcus aureus. Indian Journal of ...
https://imsear.searo.who.int/handle/123456789/143844
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological...
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological ... Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological ... Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological ...
https://iris.unimore.it/handle/11380/642502
Convergent Solid-Phase Synthesis of N-Glycopeptides Facilitated by Pseudoprolines at Consensus-Sequence Ser/Thr Residues -...Convergent Solid-Phase Synthesis of N-Glycopeptides Facilitated by Pseudoprolines at Consensus-Sequence Ser/Thr Residues -...
Convergent Solid-Phase Synthesis of N-Glycopeptides Facilitated by Pseudoprolines at Consensus-Sequence Ser/Thr Residues. In: ... Mit diesem Ansatz gelingt es, komplexe Peptide und N-Glycane effizient an der Festphase zu verknüpfen, sodass Glycopeptide und ... Convergent Solid-Phase Synthesis of N-Glycopeptides Facilitated by Pseudoprolines at Consensus-Sequence Ser/Thr Residues ...
https://eref.uni-bayreuth.de/5565/
Glycopeptides | Profiles RNS
"Glycopeptides" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Glycopeptides" by people in this website by year, and whether ... Below are the most recent publications written about "Glycopeptides" by people in Profiles. ... studies of the anti-MUC1 monoclonal antibody C595 and synthetic MUC1 mucin-core-related peptides and glycopeptides. ...
https://profiles.musc.edu/display/89428/
Sensitivity of S. aureus to beta-lactam and glycopeptide. (In vitro)Sensitivity of S. aureus to beta-lactam and glycopeptide. ("In vitro")
... aureus to beta-lactam and glycopeptide. ("In vitro"). Rev. cir. traumatol. buco-maxilo-fac. [online]. 2010, vol.10, n.4, pp. 39 ... with the aim of this study was to compare in vitro the degree of effectiveness of beta-lactam antibiotics and glycopeptide in ...
http://revodonto.bvsalud.org/scielo.php?script=sci_abstract&pid=S1808-52102010000400008&lng=en&nrm=iso&tlng=en
First Characterization of a Cluster of VanA-Type Glycopeptide-Resistant Enterococcus faecium, Colombia - Volume 8, Number 9...
Influence of oral glycopeptide on the faecal flora of human volunteers: selection of highly glycopeptide-resistant enterococci. ... Plessis P, Lamy T, Donnio PY, Autuly F, Grulois I, Le Prise PY, Epidemiologic analysis of glycopeptide-resistant enterococcus ... Glycopeptide-resistant enterococci: a decade of experience. J Med Microbiol. 1998;47:849-62. DOIPubMedGoogle Scholar ... Glycopeptide-resistant enterococci from uncooked meat. J Antimicrob Chemother. 1996;38:908-9. DOIPubMedGoogle Scholar ...
https://wwwnc-origin.cdc.gov/eid/article/8/9/01-0435
Nutrients | Free Full-Text | Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on...Nutrients | Free Full-Text | Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on...
Miller, F. Glycopeptides of human immunoglobulins. 3. The use and preparation of specific glycosidases. Immunochemistry 1972, 9 ...
https://www.mdpi.com/2072-6643/10/11/1599/htm
Quantitative Glycan Standards • QA-Bio • Sialic Acids • GlycopeptidesQuantitative Glycan Standards • QA-Bio • Sialic Acids • Glycopeptides
BioQuant Glycopeptide. BioQuant Chitotriose. BioQuant Man8. BioQuant NANA. BioQuant NGNA. 2-AB Chitotriose. 2-AA Chitotriose ... This quantitative glycopeptide standard was developed for use during the sialic acid or monosaccharide release and labeling ...
https://www.qa-bio.com/product-category/glycanstandards/quantitative_standards/
Emergence of a strain of methicillin-resistant Staphylococcus aureus with decreased susceptibility to vancomycin 7 months after...
Staphylococcus aureus with decreased susceptibility to vancomycin 7 months after treatment with glycopeptide antibiotics」主題。共同形 ... Staphylococcus aureus with decreased susceptibility to vancomycin 7 months after treatment with glycopeptide antibiotics. ...
https://tmu.pure.elsevier.com/zh/publications/emergence-of-a-strain-of-methicillin-resistant-staphylococcus-aur-2/fingerprints/
Ser(TF) antigen-biotin - Chemitope GlycopeptideSer(TF) antigen-biotin - Chemitope Glycopeptide
Galβ(1-3)GalNAcα1-O-Serine antigen N-acetylated and functionalized with a PEG3-biotin Specifications Alternative name(s) Ac-Ser(TF)-PEG3-biotin, CD176-biotin Molecular weight 913 Purity ≥95% Reference number CGB-352 Availability Inquire Related products Thr(TF) antigen-biotin, Ser(TF) antigen-biotin, Thr(Tn) antigen-bi
https://www.chemitopeglycopeptide.com/products/sertf-antigen-biotin
Françoise Van Bambeke | UCLouvainFrançoise Van Bambeke | UCLouvain
Glycopeptides in clinical development: pharmacological profile and clinical perspectives.. In: Current opinion in pharmacology ... Glycopeptides and glycodepsipeptides in clinical development: a comparative review of their antibacterial spectrum, ... structure-based study of the active site in the wild-type enzyme and in glycopeptide-dependent mutants.. In: Journal of ... Van Bambeke, Françoise ; Van Laethem, Yves ; Courvalin, Patrice ; Tulkens, Paul M.. Glycopeptide antibiotics: from conventional ...
https://uclouvain.be/en/directories/francoise.vanbambeke
Meningitis Medication: Sulfonamides, Tetracyclines, Carbapenems, Fluoroquinolones, Antibiotics, Miscellaneous, Glycopeptides,...
Glycopeptides. Class Summary. Vancomycin inhibits bacterial cell wall synthesis by blocking glycopeptide polymerization. It is ... Vancomycin is a glycopeptide antibiotic that is active against staphylococci, streptococci, and other gram-positive bacteria. ...
https://www.staging.medscape.com/answers/232915-13499/which-medications-in-the-drug-class-penicillins-amino-are-used-in-the-treatment-of-meningitis
Ester-linked glycopeptides as tools for studies of biological phenomena FULIREster-linked glycopeptides as tools for studies of biological phenomena FULIR
Horvat, Štefica; Jerić, Ivanka; Varga-Defterdarović, Lidija; Roščić, Maja; Horvat, Jaroslav (2001) Ester-linked glycopeptides ... The obtained results demonstrate that the chemical properties of the glycopeptides studied are determined by the structure and ... glycopeptides; enkephalin; opioid; imidazolidinone; Maillard; glycation; glycation end-products; maillard reaction; amino-acids ...
http://fulir.irb.hr/979/
Resistance to Glycopeptide Antibiotics - Bacterial Resistance to AntibioticsResistance to Glycopeptide Antibiotics - Bacterial Resistance to Antibiotics
Vancomycin and teicoplanin are the two glycopeptides used clinically. They bind the terminal D-alanyl-D-alanine side chains of ... aureus) and GISA (glycopeptide-insensitive Staph. aureus) are used to denote strains with vancomycin or teicoplanin MICs of 8μg ... The mechanism of glycopeptide resistance is poorly understood, but strains show longer doubling times and decreased ... Resistance to Glycopeptide Antibiotics. , Home , , Pharmaceutical Microbiology , , Pharmaceutical Microbiology , Chapter: ...
https://www.pharmacy180.com/article/resistance-to-glycopeptide-antibiotics-561/
A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a...A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a...
A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a ... A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a ... A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a ...
https://pure.mpg.de/pubman/faces/ViewItemOverviewPage.jsp?itemId=item_3248890_1
3000 Smart Words - Lesson 2: Feelings And Emotion Flashcards | Quizlet3000 Smart Words - Lesson 2: Feelings And Emotion Flashcards | Quizlet
Study with Quizlet and memorize flashcards containing terms like Guilty, Excited, Violent and more.
https://quizlet.com/vn/515953785/3000-smart-words-lesson-2-feelings-and-emotion-flash-cards/
Choice of carbapenem and glycopeptide antibiotics for list - статьяChoice of carbapenem and glycopeptide antibiotics for list - статья
antiinfective agent; carbapenem derivative; glycopeptide; clinical trial; human; publication; review; Anti-Bacterial Agents; ...
https://repository.rudn.ru/ru/records/article/record/270/
Copeptin as a marker of atherosclerosis and arteriosclerosisCopeptin as a marker of atherosclerosis and arteriosclerosis
Copeptin is associated with both coronary atherosclerosis and increased arterial stiffness in the general population. Our data indicates that copeptin may be a useful marker in the assessment of cardiovascular risk.
https://pubmed.ncbi.nlm.nih.gov/34785062/
Liberty Lite 2.0 - Microwave Peptide SynthesizerLiberty Lite 2.0 - Microwave Peptide Synthesizer
Glycopeptides (N/O-linked). View Application Data. High Throughput Synthesis. View Application Data. N-Methyl Peptides. View ...
https://cem.com/liberty-lite-2/
StaphylococcusAntibioticsSusceptibility to glycopeptidesPeptidesGISATeicoplaninAminoglycosidesAntibioticResistanceGlycoproteinsIsolatesAntimicrobial agentsAureus1999ResistantMolecularOligosaccharidesSynthesisAntigensMeSHSialic acidTherapeuticIllustrationsProteinPatientsAnalysisPlasmaStandardRouteHumanTotalNatural
Staphylococcus4
  • CoNS, primarily Staphylococcus haemolyticus and Staphylococcus epidermidis , are often resistant to multiple antibiotics, and glycopeptides have been considered the drugs of choice for the management of infections caused by these organisms [ 4 , 5 ]. (biomedcentral.com)
  • Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus. (cdc.gov)
  • Objective: The indiscriminate use of antibiotics has led to the creation of resistant microorganisms, with the aim of this study was to compare in vitro the degree of effectiveness of beta-lactam antibiotics and glycopeptide in the inhibition of Staphylococcus aureus by comparing its effectiveness in surgical wound infection. (bvsalud.org)
  • OBJECTIVES: Glycopeptides are the drugs of choice to treat infections due to methicillin-resistant Staphylococcus aureus, but since 1995, glycopeptide-intermediate S. aureus (GISA) and heterogeneous GISA (hGISA) have been reported worldwide. (archives-ouvertes.fr)
Antibiotics3
  • CoNS are usually multidrug-resistant and glycopeptide antibiotics have been to date considered the drugs of choice for treatment. (biomedcentral.com)
  • Vancomycin is in a class of medications called glycopeptide antibiotics. (medlineplus.gov)
  • Patients were excluded if there antibiotics were glycopeptide antibi- extubation (2) . (who.int)
Susceptibility to glycopeptides14
  • All clinical isolates with decreased susceptibility to glycopeptides have been oxacillin resistant and resistant to many other commonly used therapeutic agents. (cdc.gov)
  • Like oxacillin-resistant CoNS, isolates with decreased susceptibility to glycopeptides can show heteroresistance. (cdc.gov)
  • What CoNS species with decreased susceptibility to glycopeptides have been reported? (cdc.gov)
  • Isolates of S. haemolyticus and S. epidermidis with decreased susceptibility to glycopeptides have been reported. (cdc.gov)
  • Not all routine susceptibility test methods can detect CoNS isolates with decreased susceptibility to glycopeptides. (cdc.gov)
  • Should CoNS with decreased susceptibility to glycopeptides be reported to infection control? (cdc.gov)
  • The aim of this study was to characterize CoNS with reduced susceptibility to glycopeptides causing blood stream infection (BSI) in critically ill and haematology patients at the University Hospital Tor Vergata, Rome, Italy, in 2007. (biomedcentral.com)
  • Of a total of 17,418 blood cultures, 1,609 were positive for CoNS and of these, 87 (5.4%) displayed reduced susceptibility to glycopeptides. (biomedcentral.com)
  • Clinical review revealed that in 13 cases (7 in haematology and 6 in ICU), CoNS with reduced susceptibility to glycopeptides were responsible for a BSI. (biomedcentral.com)
  • Multi-resistant CoNS with reduced susceptibility to glycopeptides, although still relatively infrequent in our hospital, are emerging pathogens of clinical concern. (biomedcentral.com)
  • Occasionally, these CoNS isolates display a reduced susceptibility to glycopeptides. (biomedcentral.com)
  • Detection of reduced susceptibility to glycopeptides in S. aureus is very difficult in a routine clinical laboratory. (archives-ouvertes.fr)
  • Thus laboratories using currently standardized MIC methods cannot be expected to detect S. aureus strains that may exhibit reduced susceptibility to glycopeptides. (archives-ouvertes.fr)
  • Staphylococcal isolates with reduced susceptibility to glycopeptides, such as vancomycin and teicoplanin, are a serious public health problem because staphylococci frequently show multidrug resistance, and glycopeptides are the only remaining effective drugs. (cdc.gov)
Peptides2
  • Spencer DI, Missailidis S, Denton G, Murray A, Brady K, Matteis CI, Searle MS, Tendler SJ, Price MR. Structure/activity studies of the anti-MUC1 monoclonal antibody C595 and synthetic MUC1 mucin-core-related peptides and glycopeptides. (musc.edu)
  • Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. (ox.ac.uk)
GISA3
  • aureus ) and GISA (glycopeptide-insensitive Staph . (pharmacy180.com)
  • Since the first two VISA isolates in the United States were also resistant to teicoplanin, the term glycopeptide-intermediate S. aureus (GISA) was used to indicate this broader resistance profile. (cdc.gov)
  • Standard MIC values and current MIC breakpoints could not discriminate the hGISA/GISA phenotype from glycopeptide-susceptible S. aureus. (archives-ouvertes.fr)
Teicoplanin3
  • The term glycopeptide refers to a group of antimicrobial agents that includes vancomycin, teicoplanin, and several other antimicrobial agents currently in U. S. clinical trials. (cdc.gov)
  • Vancomycin and teicoplanin are the two glycopeptides used clinically. (pharmacy180.com)
  • Since the early reports of glycopeptide-resistant staphylococci, teicoplanin resistance has become more common than vancomycin resistance, particularly among coagulase-negative staphylococcal species ( 1 - 3 ). (cdc.gov)
Aminoglycosides1
  • Resistance against such diverse groups of drugs as β-lactams, macrolides, aminoglycosides, and glycopeptides continues to evolve. (cdc.gov)
Antibiotic3
  • But multiple resistance was accumulating and by the 1980s empirical therapy of staphylococcal infections, particularly nosocomial sepsis, was changed to the glycopeptide antibiotic vancomycin. (pharmacy180.com)
  • Vancomycin is a glycopeptide antibiotic considered the gold standard in the treatment of staphylococcal infections that are oxacillin-resistant. (bvsalud.org)
  • It is a complex, glycopeptide antibiotic containing amino acids and sugars and has high molecular 2,3 weight with activity in the pH range between 6.0 and 8.0. (bvsalud.org)
Resistance4
  • The mechanism of glycopeptide resistance is poorly understood, but strains show longer doubling times and decreased susceptibility to lysostaphin. (pharmacy180.com)
  • A cluster and humans coming into contact with the animals (farm that includes three genes, vanH , vanA , and vanX , is required for high-level resistance to glycopeptides. (cdc.gov)
  • Furthermore, nucleotide sequences related to the cluster vanHAX are present in this DNA, suggesting that the prolonged use of avoparcin in agriculture led to the uptake of glycopeptide resistance genes by animal commensal bacteria, which were subsequently transferred to humans. (cdc.gov)
  • High-level glycopeptide resistance is conferred by a nol-chloroform extractions. (cdc.gov)
Glycoproteins2
  • Oligosaccharides, glycopeptides, or glycoproteins containing terminal Neu5Ac(alpha 2-6)Gal/GalNAc sequences bound to SNA-Sepharose and were eluted with 50-100 mM lactose, whereas those with Neu5Ac(alpha 2-3)Gal/GalNAc failed to bind to this column. (eurekamag.com)
  • This enzyme is suitable for release of a broad spectrum of N-glycans (high-mannose, hybrid and complex) from glycoproteins and glycopeptides, including those from non-mammalian sources such as plants, insects and parasites carrying α1-3 linked core fucose and xylose moieties . (ludger.com)
Isolates7
  • Why is the term "glycopeptide" used, instead of vancomycin, to describe the decreased susceptibility of these CoNS isolates? (cdc.gov)
  • Because of its broader scope, the term glycopeptide is used instead of vancomycin to describe these isolates. (cdc.gov)
  • Hospital microbiology records for transplant haematology and ICU were reviewed to identify CoNS with elevated MICs for glycopeptides, and isolates were matched to clinical records to determine whether the isolates caused a BSI. (biomedcentral.com)
  • Since the majority of these isolates can be considered as contaminant, the incidence of CoNS with reduced sensitivity to glycopeptides actually causing bloodstream infections (BSI) is difficult to determine. (biomedcentral.com)
  • The objective of this study was to investigate whether glycopeptide-resistant CoNS represent a significant clinical concern by examining CoNS isolates and patient records for 2007. (biomedcentral.com)
  • Determination of glycopeptide genotype indicated the presence of the van A gene in all isolates. (cdc.gov)
  • All isolates were susceptible to glycopeptides. (who.int)
Antimicrobial agents1
  • Primers 16S 440F and 16S 1491R (Table) were ing of glycopeptide antimicrobial agents to their designed to amplify partial 16S rDNA sequences. (cdc.gov)
Aureus1
  • Sensitivity of S. aureus to beta-lactam and glycopeptide. (bvsalud.org)
19991
  • From August 1998 to October 1999, glycopeptide-resistant enterococci (GRE) were isolated from 23 infected patients at a teaching hospital in Medellín, Colombia. (cdc.gov)
Resistant2
  • Pulsed-field gel electrophoresis restriction fragment patterns of Sma I-digested genomic DNA obtained from glycopeptide-resistant Enterococcus faecium isolated at San Vicente de Paul Hospital, Bogotá, Colombia. (cdc.gov)
  • We report here the first isolation and characterization of a cluster of VanA-type glycopeptide-resistant E. faecium in a teaching hospital in Colombia. (cdc.gov)
Molecular2
  • Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity. (ox.ac.uk)
  • Source of the aeroallergen of soybean dust: a low molecular mass glycopeptide from the soybean tela. (cdc.gov)
Oligosaccharides1
  • Furthermore, the SNA-Sepharose column was capable of resolving two oligosaccharides/glycopeptides based on the number of Neu5Ac(alpha 2-6)Gal units present in each molecule. (eurekamag.com)
Synthesis1
  • Dr Barchi's career at the NCI has spanned a wide breadth of drug discovery efforts, including the synthesis of PKC and reverse transcriptase inhibitors, the development of glycopeptide antigens as vaccine candidates against HIV and cancer, as well as the discovery of several glycopeptide-analogues of Antiproliferative Factor (APF), a negative growth factor isolated from patients with interstitial cystitis. (cancer.gov)
Antigens2
  • In addition, our group developed an hybrid gold nanoparticle that can act as a vaccine delivery system for tumor-associated glycopeptide antigens. (cancer.gov)
  • Our goal is to optimize these various nanoconstructs to enhance a glycopeptide-specific immune response that will be specific for distinct tumors bearing these antigens. (cancer.gov)
MeSH1
  • Glycopeptides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
Sialic acid1
  • This quantitative glycopeptide standard was developed for use during the sialic acid or monosaccharide release and labeling process. (qa-bio.com)
Therapeutic1
  • Current focus in the lab is the discovery of novel nanoplatforms for the delivery and therapeutic applications of immunogenic glycopeptides, the search for selective antitumor agents based on APF and the conformational analysis of these synthetic analogues by NMR spectroscopy to guide further discovery efforts. (cancer.gov)
Illustrations1
  • ebook the politics of extremism in south asia: The click of this advance, High Performance Computing has not broken to stand northern illustrations and glycopeptide about the approaches of High Performance Computing. (xconsult.de)
Protein1
  • 10 kD, usually a protein or glycopeptide) that can cause production of specific IgE antibodies and typical allergic responses. (cdc.gov)
Patients3
  • 2. Antiproliferative Factor (APF): A novel antiproliferative glycopeptide from interstitial cystitis/bladder pain syndrome (IC/BPS) patients. (cancer.gov)
  • A novel glycopeptide called APF was isolated from the urine of IC/BPS patients by the team of Susan Keay at the University of Maryland and and fully characterized and synthesized in our lab. (cancer.gov)
  • La réanimation agressive, la prise en charge nutritionnelle, l'excision chirur- gicale complète des plaies infectées, la fermeture rapide des plaies, les greffes et la mise au point d'une chimiothérapie locale et systémique efficace ont permis d'améliorer grandement le taux de morbidité et de mortalité chez les patients brûlés. (who.int)
Analysis1
  • Since biochemical differences between plasma and synovial fluid fibronectins might be in part due to differences in glycosylation we have compared the carbohydrate composition of plasma Fn, synovial fluid Fn, and Fn from synoviocyte conditioned medium by biochemical assay, glycopeptide analysis, and binding to a series of lectins. (jci.org)
Plasma1
  • Glycopeptides formed from synovial fluid Fn are smaller than plasma Fn glycopeptides. (jci.org)
Standard1
  • We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. (ox.ac.uk)
Route1
  • We describe herein the assembly of hEPO(79-166), a key glycopeptide segment en route to erythropoietin, in minimally protected form. (dongsuweigroup.com)
Human1
  • The structure of the glycopeptides of a human M-immunoglobulin. (wustl.edu)
Total1
  • This graph shows the total number of publications written about "Glycopeptides" by people in this website by year, and whether "Glycopeptides" was a major or minor topic of these publications. (musc.edu)
Natural1
  • The change alters the affinity of the glycopeptide for its natural target (6) . (cdc.gov)
(emedicine.medscape.com)
(emedicine.medscape.com)
2020 Annual Report for the Emerging Infections Program for Clostridioides difficile Infection | Emerging Infections Program |...
2020 Annual Report for the Emerging Infections Program for Clostridioides difficile Infection | Emerging Infections Program |... (cdc.gov)
Nutrients | Free Full-Text | Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on...
Nutrients | Free Full-Text | Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on... (mdpi.com)
Recommendations for Preventing Transmission of Infections Among Chronic Hemodialysis Patients
Recommendations for Preventing Transmission of Infections Among Chronic Hemodialysis Patients (cdc.gov)
Intraoperative Redosing of Antibiotic for SSI Prevention
Intraoperative Redosing of Antibiotic for SSI Prevention (medscape.com)
Pediatric Bacterial Meningitis Treatment & Management: Approach Considerations, Initial Supportive Measures, Antibiotic Therapy
Pediatric Bacterial Meningitis Treatment & Management: Approach Considerations, Initial Supportive Measures, Antibiotic Therapy (medscape.com)
Figure - First Characterization of a Cluster of VanA-Type Glycopeptide-Resistant Enterococcus faecium, Colombia - Volume 8,...
Figure - First Characterization of a Cluster of VanA-Type Glycopeptide-Resistant Enterococcus faecium, Colombia - Volume 8,... (wwwnc.cdc.gov)
First Characterization of a Cluster of VanA-Type Glycopeptide-Resistant Enterococcus faecium, Colombia - Volume 8, Number 9...
First Characterization of a Cluster of VanA-Type Glycopeptide-Resistant Enterococcus faecium, Colombia - Volume 8, Number 9... (wwwnc.cdc.gov)
Antimicrobial Resistance Gene Delivery in Animal Feeds - Volume 10, Number 4-April 2004 - Emerging Infectious Diseases journal ...
Antimicrobial Resistance Gene Delivery in Animal Feeds - Volume 10, Number 4-April 2004 - Emerging Infectious Diseases journal ... (wwwnc.cdc.gov)
Figure 2 - Global Spread of Vancomycin-resistant Enterococcus faecium from Distinct Nosocomial Genetic Complex - Volume 11,...
Figure 2 - Global Spread of Vancomycin-resistant Enterococcus faecium from Distinct Nosocomial Genetic Complex - Volume 11,... (wwwnc.cdc.gov)
Guidelines for the Prevention of Intravascular Catheter-Related Infections
Guidelines for the Prevention of Intravascular Catheter-Related Infections (cdc.gov)
Granulosa-Theca Cell Tumors Medication: Antineoplastic agents, Uroprotective agents, Antiemetics
Granulosa-Theca Cell Tumors Medication: Antineoplastic agents, Uroprotective agents, Antiemetics (medscape.com)
Clinical Implications of Varying Degrees of Vancomycin Susceptilibity in Methicillin-Resistant Staphylococcus aureus Bacteremia...
Clinical Implications of Varying Degrees of Vancomycin Susceptilibity in Methicillin-Resistant Staphylococcus aureus Bacteremia... (wwwnc.cdc.gov)
Figure 2 - Clinical Implications of Varying Degrees of Vancomycin Susceptilibity in Methicillin-Resistant Staphylococcus aureus...
Figure 2 - Clinical Implications of Varying Degrees of Vancomycin Susceptilibity in Methicillin-Resistant Staphylococcus aureus... (wwwnc.cdc.gov)
Liberty Lite 2.0 - Microwave Peptide Synthesizer
Liberty Lite 2.0 - Microwave Peptide Synthesizer (cem.com)
Vancomycin: MedlinePlus Drug Information
Vancomycin: MedlinePlus Drug Information (medlineplus.gov)
Methicillin-Resistant Staphylococcus aureus ST398 in Swine Farm Personnel, Belgium - Volume 15, Number 7-July 2009 - Emerging...
Methicillin-Resistant Staphylococcus aureus ST398 in Swine Farm Personnel, Belgium - Volume 15, Number 7-July 2009 - Emerging... (wwwnc.cdc.gov)
Antibiotic Resistance Patterns of Bacterial Isolates from Blood in San Francisco County, California, 1996-1999 - Volume 8,...
Antibiotic Resistance Patterns of Bacterial Isolates from Blood in San Francisco County, California, 1996-1999 - Volume 8,... (wwwnc.cdc.gov)
Staphylococcus Aureus Infection: Practice Essentials, Background, Pathophysiology
Staphylococcus Aureus Infection: Practice Essentials, Background, Pathophysiology (emedicine.medscape.com)
Infections nosocomiales : hausse inquiétante des bactéries multi- et hautement résistantes
Infections nosocomiales : hausse inquiétante des bactéries multi- et hautement résistantes (medscape.com)
Volume 7, Number 2-April 2001 - Emerging Infectious Diseases journal - CDC
Volume 7, Number 2-April 2001 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Co-trimoxazole-Sensitive, Methicillin-Resistant Staphylococcus aureus, Israel, 1988-1997 - Volume 9, Number 9-September 2003 -...
Co-trimoxazole-Sensitive, Methicillin-Resistant Staphylococcus aureus, Israel, 1988-1997 - Volume 9, Number 9-September 2003 -... (wwwnc.cdc.gov)
Conference Summaries - Emerging Infectious Diseases journal - CDC
Conference Summaries - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Novel Antibiotics for the Treatment of Staphylococcus aureus
Novel Antibiotics for the Treatment of Staphylococcus aureus (medscape.com)
Genetics of Antimicrobial Resistance in Staphylococcus Aureus
Genetics of Antimicrobial Resistance in Staphylococcus Aureus (medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
(emedicine.medscape.com)
DailyMed - Search Results for Glycopeptide Antibiotics
DailyMed - Search Results for Glycopeptide Antibiotics (dailymed.nlm.nih.gov)