Glycine
Receptors, Glycine
Glycine Agents
Glycine Plasma Membrane Transport Proteins
Glycine Dehydrogenase (Decarboxylating)
Strychnine
Glycine N-Methyltransferase
Glycine Decarboxylase Complex H-Protein
Betaine
Glycine Decarboxylase Complex
Soybeans
Glycine Hydroxymethyltransferase
Amino Acid Transport Systems, Neutral
Amino Acids
Molecular Sequence Data
Taurine
Amino Acid Sequence
Aminomethyltransferase
Amino Acid Oxidoreductases
Receptors, N-Methyl-D-Aspartate
Alanine
Serine
Receptors, Neurotransmitter
Glycine Dehydrogenase
Amidinotransferases
Mutation
Proline
RNA, Transfer, Gly
Base Sequence
Picrotoxin
Glycine Transaminase
Aminobutyrates
Transferases
Mutagenesis, Site-Directed
Aspartic Acid
beta-Alanine
Receptors, GABA
Betaine-Aldehyde Dehydrogenase
GABA Antagonists
Patch-Clamp Techniques
Benzoic Acid
Hydroxymethyl and Formyl Transferases
Binding Sites
Glutamic Acid
N-Methylaspartate
Neurons
Carrier Proteins
Glutamates
Excitatory Amino Acid Antagonists
Escherichia coli
Bicuculline
Structure-Activity Relationship
Choline Dehydrogenase
Models, Molecular
Amino Acid Substitution
Xenopus laevis
Osteogenesis Imperfecta
Sequence Homology, Amino Acid
Osmotic Pressure
Protein Conformation
Oocytes
Neural Inhibition
Dose-Response Relationship, Drug
Carbon Isotopes
Biological Transport
Cloning, Molecular
Hsp60 is targeted to a cryptic mitochondrion-derived organelle ("crypton") in the microaerophilic protozoan parasite Entamoeba histolytica. (1/5843)
Entamoeba histolytica is a microaerophilic protozoan parasite in which neither mitochondria nor mitochondrion-derived organelles have been previously observed. Recently, a segment of an E. histolytica gene was identified that encoded a protein similar to the mitochondrial 60-kDa heat shock protein (Hsp60 or chaperonin 60), which refolds nuclear-encoded proteins after passage through organellar membranes. The possible function and localization of the amebic Hsp60 were explored here. Like Hsp60 of mitochondria, amebic Hsp60 RNA and protein were both strongly induced by incubating parasites at 42 degreesC. 5' and 3' rapid amplifications of cDNA ends were used to obtain the entire E. histolytica hsp60 coding region, which predicted a 536-amino-acid Hsp60. The E. histolytica hsp60 gene protected from heat shock Escherichia coli groEL mutants, demonstrating the chaperonin function of the amebic Hsp60. The E. histolytica Hsp60, which lacked characteristic carboxy-terminal Gly-Met repeats, had a 21-amino-acid amino-terminal, organelle-targeting presequence that was cleaved in vivo. This presequence was necessary to target Hsp60 to one (and occasionally two or three) short, cylindrical organelle(s). In contrast, amebic alcohol dehydrogenase 1 and ferredoxin, which are bacteria-like enzymes, were diffusely distributed throughout the cytosol. We suggest that the Hsp60-associated, mitochondrion-derived organelle identified here be named "crypton," as its structure was previously hidden and its function is still cryptic. (+info)Carbon 13 NMR study of nonenzymatic reactions of pyridoxal 5'-phosphate with selected amino acids and of related reactions. (2/5843)
Carbon 13 nuclear magnetic resonance spectroscopy has been used to monitor the nonenzymatic reactions of pyridoxal 5'-phosphate with glycine, alanine, valine, serine, and with several other model compounds. Isotopically enriched amino acids were employed so that low concentrations could be utilized while still allowing relatively rapid acquisition of spectral data. The results for alanine and serine are particularly noteworthy in that alanine is deaminated to pyruvate and pyruvate is aminated to alanine, but contrary to the enzymatic reactions of various serine dehydratases wherein serine is converted to pyruvate, the nonenzymatic reaction utilizing serine results in hydroxypruvate rather than pyruvate formation. In the reverse reaction, hydroxypyruvate is aminated to serine but very inefficiently relative to the amination of pyruvate to alanine. The experimental results have been formulated into a proposed reaction mechanism for deamination of amino acids by pyridoxal-P. (+info)Presence of the vesicular inhibitory amino acid transporter in GABAergic and glycinergic synaptic terminal boutons. (3/5843)
The characterization of the Caenorhabditis elegans unc-47 gene recently allowed the identification of a mammalian (gamma)-amino butyric acid (GABA) transporter, presumed to be located in the synaptic vesicle membrane. In situ hybridization data in rat brain suggested that it might also take up glycine and thus represent a general Vesicular Inhibitory Amino Acid Transporter (VIAAT). In the present study, we have investigated the localization of VIAAT in neurons by using a polyclonal antibody raised against the hydrophilic N-terminal domain of the protein. Light microscopy and immunocytochemistry in primary cultures or tissue sections of the rat spinal cord revealed that VIAAT was localized in a subset (63-65%) of synaptophysin-immunoreactive terminal boutons; among the VIAAT-positive terminals around motoneuronal somata, 32.9% of them were also immunoreactive for GAD65, a marker of GABAergic presynaptic endings. Labelling was also found apposed to clusters positive for the glycine receptor or for its associated protein gephyrin. At the ultrastructural level, VIAAT immunoreactivity was restricted to presynaptic boutons exhibiting classical inhibitory features and, within the boutons, concentrated over synaptic vesicle clusters. Pre-embedding detection of VIAAT followed by post-embedding detection of GABA or glycine on serial sections of the spinal cord or cerebellar cortex indicated that VIAAT was present in glycine-, GABA- or GABA- and glycine-containing boutons. Taken together, these data further support the view of a common vesicular transporter for these two inhibitory transmitters, which would be responsible for their costorage in the same synaptic vesicle and subsequent corelease at mixed GABA-and-glycine synapses. (+info)Multiplex sequence analysis demonstrates the competitive growth advantage of the A-to-G mutants of clarithromycin-resistant Helicobacter pylori. (4/5843)
Clarithromycin resistance in Helicobacter pylori is due to point mutation within the 23S rRNA. We examined the growth rates of different types of site-directed mutants and demonstrated quantitatively the competitive growth advantage of A-to-G mutants over other types of mutants by a multiplex sequencing assay. The results provide a rational explanation of why A-to-G mutants are predominantly observed among clarithromycin-resistant clinical isolates. (+info)The role of proline and glycine in determining the backbone flexibility of a channel-forming peptide. (5/5843)
Alamethicin is a helical 20-amino acid voltage-gated channel-forming peptide, which is known to exhibit segmental flexibility in solution along its backbone near alpha-methylalanine (MeA)-10 and Gly-11. In an alpha-helical configuration, MeA at position 10 would normally hydrogen-bond with position 14, but the presence of proline at this position prevents the formation of this interhelical hydrogen bond. To determine whether the presence of proline at position 14 contributes to the flexibility of this helix, two analogs of alamethicin were synthesized, one with proline 14 replaced by alanine and another with both proline 14 and glycine 11 replaced by alanine. The C-termini of these peptides were derivatized with a proxyl nitroxide, and paramagnetic enhancements produced by the nitroxide on the Calpha protons were used to estimate r-6 weighted distances between the nitroxide and the backbone protons. When compared to native alamethicin, the analog lacking proline 14 exhibited similar C-terminal to Calpha proton distances, indicating that substitution of proline alone does not alter the flexibility of this helix; however, the subsequent removal of glycine 11 resulted in a significant increase in the averaged distances between the C- and N-termini. Thus, the G-X-X-P motif found in alamethicin appears to be largely responsible for mediating high-amplitude bending motions that have been observed in the central helical domain of alamethicin in methanol. To determine whether these substitutions alter the channel behavior of alamethicin, the macroscopic and single-channel currents produced by these analogs were compared. Although the substitution of the G-X-X-P motif produces channels with altered characteristics, this motif is not essential to achieve voltage-dependent gating or alamethicin-like behavior. (+info)NMDA receptor characterization and subunit expression in rat cultured mesencephalic neurones. (6/5843)
1. NMDA-induced changes in free intracellular Ca2+ concentration ([Ca2+]i) were determined in individual cultured rat mesencephalic neurones by the fura-2 method. mRNA expression encoding NMDA receptor subunits (NR1, NR2A-D) was examined by RT-PCR. 2. NMDA (1-100 microM, plus 10 microM glycine) induced a concentration-dependent increase in [Ca2+]i (EC50 = 5.7 microM). The effect of NMDA was virtually insensitive to tetrodotoxin (0.3 microM) and nitrendipine (1 microM), but dependent on extracellular Ca2+. 5,7-Dichlorokynurenic acid (10 microM), a specific antagonist at the glycine binding site on the NMDA receptor, abolished the NMDA response. 3. Memantine, an open-channel blocker, and ifenprodil, a preferential non-competitive NR1/NR2B receptor antagonist diminished the NMDA effect with an IC50 value of 0.17 and 1 microM, respectively. Ethanol at 50 and 100 mM caused about 25 and 45%-inhibition, respectively. 4. Agarose gel analysis of the PCR products followed by ethidium bromide fluorescence or CSPD chemiluminescence detection revealed an almost exclusive expression of the NR1 splice variants lacking exon (E) 5 and E22. The 3' splice form without both E21 and E22 exceeded that containing E21 by approximately 4 fold. The relative amounts of NR2A, NR2B, NR2C corresponded to approximately 1:2:1. NR2D mRNA was also detectable. 5. In conclusion, mesencephalic neurones bear ethanol-sensitive NMDA receptors which might be involved in the development of ethanol dependence and withdrawal. The high affinity of NMDA to this receptor, its sensitivity to ifenprodil and memantine may suggest that the mesencephalic NMDA receptor comprises the NR1 splice variant lacking E5, NR2B, and NR2C, respectively. (+info)Antagonist activity of alpha-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells. (7/5843)
1. We have investigated the antagonist properties of 6 alpha-substituted phenylglycine analogues based on the structure of 4-carboxyphenylglycine (4-CPG) for group I metabotropic glutamate receptors (mGlu1alpha and mGlu5a) permanently expressed in CHO cells. 2. (S)-4-CPG and (S)-MCPG were the most selective mGlu1alpha receptor antagonists. Longer chain alpha-carbon substitutions resulted in a progressive loss of antagonist affinity at mGlu1alpha receptors but not at mGlu5a receptors. Thus mGlu1alpha receptor antagonists require small aliphatic groups at the alpha-position. Alpha-cyclopropyl-4-CPG showed a tendency towards mGlu5a selectivity, suggesting that bulky groups at this position may favour mGlu5a receptor antagonism. 3. We demonstrate that the mGlu5a receptor displays agonist-dependent antagonism. L-glutamate-induced Ca2+ release in mGlu5a receptor expressing cells was more susceptible to antagonism by cyclic alpha-carbon derivatives than (S)-3,5-dihydroxyphenylglycine (DHPG)-induced Ca2+ release in the same cell line. 4. The data presented suggests that mGlu1alpha and mGlu5a receptors have different steric and/or conformational requirements for the binding of antagonists and different amino acids which could interact with agonists. 5. These phenylglycine analogues could provide leads for the development of subtype selective antagonists. (+info)Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord. (8/5843)
1. The metabotropic glutamate receptor (mGluR) agonist trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) (10-100 microM) depolarized isolated frog spinal cord motoneurones, a process sensitive to kynurenate (1.0 mM) and tetrodotoxin (TTX) (0.783 microM). 2. In the presence of NMDA open channel blockers [Mg2+; (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK801); 3,5-dimethyl-1-adamantanamine hydrochloride (memantine)] and TTX, trans-ACPD significantly potentiated NMDA-induced motoneurone depolarizations, but not alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate (AMPA)- or kainate-induced depolarizations. 3. NMDA potentiation was blocked by (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) (240 microM), but not by alpha-methyl-(2S,3S,4S)-alpha-(carboxycyclopropyl)-glycine (MCCG) (290 microM) or by alpha-methyl-(S)-2-amino-4-phosphonobutyrate (L-MAP4) (250 microM), and was mimicked by 3,5-dihydroxyphenylglycine (DHPG) (30 microM), but not by L(+)-2-amino-4-phosphonobutyrate (L-AP4) (100 microM). Therefore, trans-ACPD's facilitatory effects appear to involve group I mGluRs. 4. Potentiation was prevented by the G-protein decoupling agent pertussis toxin (3-6 ng ml(-1), 36 h preincubation). The protein kinase C inhibitors staurosporine (2.0 microM) and N-(2-aminoethyl)-5-isoquinolinesulphonamide HCI (H9) (77 microM) did not significantly reduce enhanced NMDA responses. Protein kinase C activation with phorbol-12-myristate 13-acetate (5.0 microM) had no effect. 5. Intracellular Ca2+ depletion with thapsigargin (0.1 microM) (which inhibits Ca2+/ATPase), 1,2-bis(O-aminophenoxy)ethane-N,N,N',N'-tetracetic acid acetyl methyl ester (BAPTA-AM) (50 microM) (which buffers elevations of [Ca2+]i), and bathing spinal cords in nominally Ca2+-free medium all reduced trans-ACPD's effects. 6. The calmodulin antagonists N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W7) (100 microM) and chlorpromazine (100 microM) diminished the potentiation. 7. In summary, group I mGluRs selectively facilitate NMDA-depolarization of frog motoneurones via a G-protein, a rise in [Ca2+]i from the presumed generation of phosphoinositides, binding of Ca2+ to calmodulin, and lessening of the Mg2+-produced channel block of the NMDA receptor. (+info)1. Bone fractures: The most common symptom of OI is an increased risk of fractures, which can occur with minimal trauma or even without any apparent cause.
2. Dental problems: People with OI may have poorly formed teeth, tooth decay, and gum disease.
3. Short stature: Many individuals with OI are short in stature, due to the effects of chronic fractures and pain on growth and development.
4. Muscle weakness: Some people with OI may experience muscle weakness, particularly in the limbs.
5. Joint problems: OI can cause issues with joint mobility and stability, leading to arthritis and other degenerative conditions.
6. Scoliosis: Curvature of the spine is common in people with OI, which can lead to back pain and respiratory problems.
7. Blue sclerae: A distinctive feature of OI is the presence of blue-colored sclerae (the white part of the eye).
8. Other symptoms: Some people with OI may experience hearing loss, vision problems, and delayed development.
There are several types of OI, each caused by a mutation in a specific gene. The most common forms of OI are type I, type II, and type III. Type I is the mildest form and type III is the most severe. There is no cure for OI, but treatment focuses on managing symptoms and preventing complications. This may include:
1. Bracing and orthotics: To support weakened bones and improve posture.
2. Physical therapy: To maintain muscle strength and flexibility.
3. Pain management: To reduce the risk of chronic pain and improve quality of life.
4. Dental care: Regular dental check-ups and appropriate treatment to prevent tooth decay and gum disease.
5. Respiratory care: To manage breathing problems and prevent respiratory infections.
6. Monitoring for hearing loss: Regular hearing tests to detect any hearing loss and provide appropriate intervention.
7. Early intervention: To help children with OI develop skills and abilities to their full potential.
8. Genetic counseling: For families with a history of OI, to understand the risks and implications for future pregnancies.
It's important for people with OI to work closely with their healthcare provider to manage their condition and prevent complications. With proper care and support, many people with OI can lead active and fulfilling lives.
Glycine
Glycine (watch)
Glycine receptor
Glycine tomentella
Glycine microphylla
Glycine mollis
Glycine latifolia
Glycine clandestina
Glycine transporter
Glycine soja
Glycine oxidase
Glycine viscosa
Glycine formimidoyltransferase
Glycine canescens
Glycine (plant)
Glycine reductase
Glycine latrobeana
Glycine (disambiguation)
Glycine dehydrogenase
Glycine transaminase
Glycine encephalopathy
Glycine tabacina
Glycine riboswitch
Glycine dehydrogenase (cytochrome)
Glycine receptor antagonist
Glycine N-carboxyanhydride
Cyclic glycine-proline
Glycine N-methyltransferase
Mitochondrial glycine transporter
Glycine C-acetyltransferase
Glycine encephalopathy - About the Disease - Genetic and Rare Diseases Information Center
DailyMed - GLYCINE solution
Glycine 10877-J
MedlinePlus - Search Results for: GLYCINE
Glycine Supplements & Reviews | Thorne
GLYCINE - Books - NCBI
Arginine:glycine amidinotransferase deficiency | MedlinePlus Genetics
Airpilot Collection | Glycine
Glycine
Grant Abstract: Role of Glycine Metabolism in Cardiovascular Disease
GLYCINE/PD - Search Results - PubMed
Hach Glycine Reagent
Neuroleptic effects on serine and glycine metabolism - PubMed
reverse D amino acid mouse proline-glycine-proline peptide | Semantic Scholar
Glycine Airman Airfighter Automatic GMT Chronograph Watch 3921.16.LB96 - Oak Gem
Glycine Sticks (3 grams) | 30 sticks | Metabolic Maintenance - Blue Sky Vitamin
Request Customization - Capryloyl Glycine Market Size | Global Trends Report, 2023-2032
SC-49992, a mimetic of the peptide arginine-glycine-aspartic acid-phenylalanine that blocks platelet aggregation, enhances...
Urinary Excretion of Nitrogen from 15N-Labelled Amino Acids in the Malnourished and Recovered Child I. Glycine and Lysine |...
Hydration number of glycine in aqueous solution: An experimental estimate | UBC Chemistry
Pharmacological screening of glycine amino acid prodrug of acetaminophen,<b>Arun Parashar</b>: Indian Journal of...
Aphis (Aphis) glycines Matsumura, 1917 | Agriculture and Food
SHARCNET: Publication: Computational surface chemistry of glycine on Si(111)7x7 and Si(100)2x1: Dissociative adsorption through...
Identification of a new ligand binding domain in the alpha1 subunit of the inhibitory glycine receptor | Garvan Institute of...
Garnier Thiebaut Glycines Parme Napkin
Transpiration response of 'slow-wilting' and commercial soybean (Glycine max (L.) Merr.) genotypes to three aquaporin...
Chambre d'hôtes 'La Glycine', room La Menitré, Maine et Loire
Соя культурная - Glycine max - List of subtaxa - Plantarium
Glycine
Amino acids3
- creatine from the protein building blocks (amino acids) glycine , arginine, and methionine. (nih.gov)
- Glycine, which is the smallest of the known amino acids, also helps the body in a variety of other ways. (blueskyvitamin.com)
- Glycine is one of the proteinogenic amino acids. (iiab.me)
Aqueous solution2
- An experimental estimate of hydration number, N-H, of glycine in aqueous solution is given by using the calorimetric methodology developed by us earlier, which is briefly reviewed. (ubc.ca)
- In aqueous solution, glycine itself is amphoteric: at low pH the molecule can be protonated with a pK a of about 2.4 and at high pH it loses a proton with a pK a of about 9.6 (precise values of pK a depend on temperature and ionic strength). (iiab.me)
Serine11
- Glycine which enters the systemic circulation is converted to serine and glyoxylic acid. (nih.gov)
- Glycine is a non-chiral amino acid that can be synthesized in the body from the amino acid serine by Serine Hydroxymethyltransferase. (thomassci.com)
- Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia. (ox.ac.uk)
- The NMDA receptor co-agonists D-serine and glycine are thought to contribute to glutamatergic dysfunction in schizophrenia. (ox.ac.uk)
- They are removed from the synapse by specific neuronal and glial transporters, the status of which is clearly relevant to theories of D-serine and glycine function in the disorder. (ox.ac.uk)
- D-serine is primarily transported by Asc-1, and glycine by GlyT1 but maybe also by SNAT2. (ox.ac.uk)
- Correlation between the expression of serine/glycine metabolism-related proteins and clinicopathologic factors in papillary carcinoma. (biomedcentral.com)
- EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. (bvsalud.org)
- Here, we demonstrate that EWS-FLI1 positively regulates the expression of proteins required for serine - glycine biosynthesis and uptake of the alternative nutrient source glutamine . (bvsalud.org)
- Inhibition of serine - glycine biosynthesis in EWS cells impacts their redox state leading to an accumulation of reactive oxygen species , DNA damage , and apoptosis . (bvsalud.org)
- In summary, our study demonstrates that EWS-FLI1 reprograms the metabolism of EWS cells and that serine - glycine metabolism or glutamine uptake are potential targetable vulnerabilities in this tumor type. (bvsalud.org)
Merr3
Metabolism2
- Under such conditions ammonia resulting from metabolism of glycine may accumulate in the blood. (nih.gov)
- Since this cardio-protective allele is the major genetic determinant of increased plasma glycine levels in humans, we proposed a series of integrative clinical, genetics, bioinformatics, and dietary approaches to investigate the role of glycine metabolism in CVD, which was recently funded through NHLBI grant (R01HL133169). (nih.gov)
Enzyme6
- Glycine encephalopathy is caused by changes in the AMT, GLDC or GCSH genes which result in a deficiency of the enzyme that break-up the glycine. (nih.gov)
- Diagnosis is based in the symptoms, the high glycine levels and the enzyme deficiency, as well as genetic testing. (nih.gov)
- gene provides instructions for making an enzyme called glycine dehydrogenase. (nih.gov)
- GNMT gene provides instructions for producing the enzyme glycine N-methyltransferase. (nih.gov)
- The GATM gene provides instructions for making the enzyme arginine:glycine amidinotransferase. (medlineplus.gov)
- GATM gene mutations impair the ability of the arginine:glycine amidinotransferase enzyme to participate in creatine synthesis, resulting in a shortage of creatine. (medlineplus.gov)
Abnormally high levels2
Arginine9
- Children with arginine:glycine amidinotransferase deficiency may not gain weight and grow at the expected rate (failure to thrive), and have delayed development of motor skills such as sitting and walking. (medlineplus.gov)
- The prevalence of arginine:glycine amidinotransferase deficiency is unknown. (medlineplus.gov)
- Mutations in the GATM gene cause arginine:glycine amidinotransferase deficiency. (medlineplus.gov)
- glycine, arginine, and methionine. (medlineplus.gov)
- Specifically, arginine:glycine amidinotransferase controls the first step of the process. (medlineplus.gov)
- In this step, a compound called guanidinoacetic acid is produced by transferring a cluster of nitrogen and hydrogen atoms called a guanidino group from arginine to glycine. (medlineplus.gov)
- The effects of arginine:glycine amidinotransferase deficiency are most severe in organs and tissues that require large amounts of energy, especially the brain. (medlineplus.gov)
- Edvardson S, Korman SH, Livne A, Shaag A, Saada A, Nalbandian R, Allouche-Arnon H, Gomori JM, Katz-Brull R. l-arginine:glycine amidinotransferase (AGAT) deficiency: clinical presentation and response to treatment in two patients with a novel mutation. (medlineplus.gov)
- 8-Guanidino-octanoyl-aspartic acid-phenylalanine (SC-49992), a mimetic of the tetrapeptide arginine-glycine-aspartic acid-phenylalanine, is a potent inhibitor of platelet aggregation. (aspetjournals.org)
Encephalopathy3
Deficiency1
- glycine amidinotransferase deficiency is an inherited disorder that primarily affects the brain. (nih.gov)
Inhibitory2
- In this study, we investigated the role of 12 contiguous residues of the inhibitory glycine receptor that define the proposed ""loop A"" ligand binding domain. (garvan.org.au)
- Glycine is also an inhibitory neurotransmitter - interference with its release within the spinal cord (such as during a Clostridium tetani infection) can cause spastic paralysis due to uninhibited muscle contraction. (iiab.me)
Transporters1
- The extracellular concentrations of glycine are regulated by Na+/Cl(-)-dependent glycine transporters (GlyTs), which are expressed in neurons and adjacent glial cells. (nih.gov)
Molecule1
- As a bifunctional molecule, glycine reacts with many reagents. (iiab.me)
Subunit1
- part, the alpha (α)1 subunit, of the glycine receptor protein. (nih.gov)
Neurotransmitter1
- Glycine has multiple neurotransmitter functions in the central nervous system (CNS). (nih.gov)
COOH1
- Each liter contains 15 g Glycine, USP (NH 2 CH 2 COOH) in water for injection. (nih.gov)
Receptors1
- Unchanged GlyT1 suggests that glycine transport is not markedly affected in schizophrenia, and therefore that increased synaptic removal is not the basis for the putative deficit in glycine modulation of NMDA receptors in the disorder. (ox.ac.uk)
Genetic3
- We confirmed the physiological relevance of these observations to humans using bioinformatics analyses with publicly available genetic data, which revealed that subjects carrying the CPS1 glycine-raising allele had both decreased vitamin B12 levels and exhibited the same pattern of hematological perturbations observed in glycine-fed mice. (nih.gov)
- An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Glycine (56-40-6). (nih.gov)
- Genetic Toxicity Evaluation of Glycine in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
Ammonia1
- Glycine is also cogenerated as an impurity in the synthesis of EDTA, arising from reactions of the ammonia coproduct. (iiab.me)
Lysine2
- 1. Glycine and lysine with the α-amino nitrogen labelled with 15 N were fed to marasmic and recovered infants. (portlandpress.com)
- 3. [ 15 N]Lysine was retained to a greater extent than [ 15 N]glycine in marasmus and after recovery. (portlandpress.com)
Glutathione2
- The role of the glycine triad in human glutathione synthetase. (nih.gov)
- The glycine in Glycine Sticks [3 grams] 30 sticks by Metabolic Maintenance helps in the production of the antioxidant glutathione, which supports the immune system. (blueskyvitamin.com)
Expression1
- A fourth mutant, W94A, failed to give rise to any glycine-activated currents, although cell-surface expression was observed, suggesting that this residue may also be involved in agonist binding. (garvan.org.au)
Species1
- Glycine hydrochloride, in addition to the role of hydration center, seems also to act as a typical hydrophilic species such as polyols, urea, or polyethylene glycols. (ubc.ca)
Supplemental1
- Glycine Sticks [3 grams] 30 sticks by Metabolic Maintenance are a supplemental form of glycine that helps increase glycine levels in the body. (blueskyvitamin.com)
Humans1
- Of note, the same CPS1 variant was also recently reported as being associated with reduced platelet count, suggesting that decreased thrombotic potential could be another athero-protective consequence of genetically elevated glycine levels in humans. (nih.gov)
Chemistry3
- Glycine is commonly used as a component in Tris-glycine and Tris-glycine-SDS running buffers for polyacrylamide gel electrophoresis, a component of Towbin's transfer buffer for Western blots, a buffer substance in cryoenzymology, in osmotic pressure maintenance in isoelectric focusing of erythrocytes, salting-in effect in protein chemistry, and as a buffer component in the coupled phosphatase-kinase reaction for end labelling of restriction fragments. (thomassci.com)
- SHARCNET: Publication: Computational surface chemistry of glycine on Si(111)7x7 and Si(100)2x1: Dissociative adsorption through adduct formation. (sharcnet.ca)
- Publication: Computational surface chemistry of glycine on Si(111)7x7 and Si(100)2x1: Dissociative adsorption through adduct formation. (sharcnet.ca)
Synthesis1
- Although glycine can be isolated from hydrolyzed protein, this is not used for industrial production, as it can be manufactured more conveniently by chemical synthesis. (iiab.me)
Levels4
- Transient form: Symptoms are similar to the classic form, but glycine levels decrease and the symptoms may improve within time. (nih.gov)
- As part of the studies proposed in R01HL133169, we conducted a 16-week feeding study in apolipoprotein-E deficient (ApoE-/-) mice, which resulted in 2-fold increased plasma glycine levels, and are currently in the process of completing the molecular, metabolomics, and atherosclerosis-related experiments. (nih.gov)
- This administrative supplement seeks to address this question through another 16-week mouse glycine feeding study, whereby blood counts and plasma vitamin B12 levels will be measured on a weekly basis, followed by quantification of hepatic vitamin B12 content at the end of the dietary study. (nih.gov)
- As glycine does not change blood glucose levels, Glycine Sticks [3 grams] 30 sticks by Metabolic Maintenance may offer a sweetener solution to people with hypoglycemia. (blueskyvitamin.com)
Form2
System2
Study1
- In the present study, chemopreventive potential of Glycine max (G. Max) seeds was examined against DMBA-induced skin and MCA-induced cervical papillomagenesis in Swiss albino mice. (who.int)
Center2
- Glycine does not have a chiral center, so it is the only amino acid with no asymmetric carbon. (thomassci.com)
- Both glycine and sodium glycinate seem to work purely as a hydration center without altering the nature of the bulk H2O away from the hydration shell. (ubc.ca)
Functions1
- Glycine functions as a bidentate ligand for many metal ions. (iiab.me)
Content1
- We use cookies to better understand how you use the Glycine site so that we can personalize content and advertising to improve your user experience. (glycine-watch.ch)
Potential3
- Taken together, these exciting new results have led our project in a new direction that suggest another potential atheroprotective mechanism of glycine is through lowering of platelets and leukocytes, which could be mediated through a mechanism involving vitamin B12-availability/absorption. (nih.gov)
- IMSEAR at SEARO: Chemomodulatory potential of Glycine max against murine skin and cervical papillomagenesis. (who.int)
- Singh M, Mendez E, Rao A Ramesha, Kale R K. Chemomodulatory potential of Glycine max against murine skin and cervical papillomagenesis. (who.int)
Body1
- The body produces glycine. (blueskyvitamin.com)
Water1
- For 500ml of 2.5 M glycine dissolve 93.8g in water to 500ml. (openwetware.org)
Brain1
- Glycine is a chemical messenger that transmits signals in the brain. (nih.gov)
Studies1
- Animal reproduction studies have not been conducted with 1.5% Glycine Irrigation, USP. (nih.gov)
Group1
- Acetaminophen prodrug was synthesized by esterification between the carboxyl group of amino acid glycine and hydroxyl group of acetaminophen. (ijp-online.com)