Glycerophospholipids: Derivatives of phosphatidic acid in which the hydrophobic regions are composed of two fatty acids and a polar alcohol is joined to the C-3 position of glycerol through a phosphodiester bond. They are named according to their polar head groups, such as phosphatidylcholine and phosphatidylethanolamine.Plasmalogens: GLYCEROPHOSPHOLIPIDS in which one of the two acyl chains is attached to glycerol with an ether alkenyl linkage instead of an ester as with the other glycerophospholipids.Acyltransferases: Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.Glycerylphosphorylcholine: A component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. (From Stedman, 26th ed) It counteracts the effects of urea on enzymes and other macromolecules.Ethanolamine: A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.Phosphatidic Acids: Fatty acid derivatives of glycerophosphates. They are composed of glycerol bound in ester linkage with 1 mole of phosphoric acid at the terminal 3-hydroxyl group and with 2 moles of fatty acids at the other two hydroxyl groups.Phosphatidylcholines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.Glyceryl Ethers: Compounds in which one or more of the three hydroxyl groups of glycerol are in ethereal linkage with a saturated or unsaturated aliphatic alcohol; one or two of the hydroxyl groups of glycerol may be esterified. These compounds have been found in various animal tissue.Phosphatidylethanolamines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Aeromonas: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs singly, in pairs, or in short chains. Its organisms are found in fresh water and sewage and are pathogenic to humans, frogs, and fish.Sphingolipids: A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)Lipid Metabolism: Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.Acylation: The addition of an organic acid radical into a molecule.Phospholipases: A class of enzymes that catalyze the hydrolysis of phosphoglycerides or glycerophosphatidates. EC 3.1.-.Membrane Lipids: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.Phospholipases A: Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Phospholipases A2: Phospholipases that hydrolyze the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.Sphingomyelins: A class of sphingolipids found largely in the brain and other nervous tissue. They contain phosphocholine or phosphoethanolamine as their polar head group so therefore are the only sphingolipids classified as PHOSPHOLIPIDS.Choline: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.Ceramides: Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Cardiolipins: Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Mitochondrial ADP, ATP Translocases: A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.Barth Syndrome: Rare congenital X-linked disorder of lipid metabolism. Barth syndrome is transmitted in an X-linked recessive pattern. The syndrome is characterized by muscular weakness, growth retardation, DILATED CARDIOMYOPATHY, variable NEUTROPENIA, 3-methylglutaconic aciduria (type II) and decreases in mitochondrial CARDIOLIPIN level. Other biochemical and morphological mitochondrial abnormalities also exist.Oxidative Phosphorylation: Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.Glycerol: A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.Skin Cream: A water-soluble medicinal preparation applied to the skin.Hepatitis, Infectious Canine: A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.Eriobotrya: A plant genus of the family ROSACEAE that is the source of an edible fruit. Members contain TRITERPENES.Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.Dermatitis, Atopic: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.Rosacea: A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is characterized by FLUSHING; ERYTHEMA; EDEMA; RHINOPHYMA; papules; and ocular symptoms. It may occur at any age but typically after age 30. There are various subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous, and ocular (National Rosacea Society's Expert Committee on the Classification and Staging of Rosacea, J Am Acad Dermatol 2002; 46:584-7).Tandem Mass Spectrometry: A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Fatty Acid Synthases: Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives.Plastids: Self-replicating cytoplasmic organelles of plant and algal cells that contain pigments and may synthesize and accumulate various substances. PLASTID GENOMES are used in phylogenetic studies.TriglyceridesAlkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Fatty Acid Synthase, Type I: Animal form of fatty acid synthase which is encoded by a single gene and consists of seven catalytic domains and is functional as a homodimer. It is overexpressed in some NEOPLASMS and is a target in humans of some ANTINEOPLASTIC AGENTS and some ANTI-OBESITY AGENTS.Choline Kinase: An enzyme that is active in the first step of choline phosphoglyceride (lecithin) biosynthesis by catalyzing the phosphorylation of choline to phosphorylcholine in the presence of ATP. Ethanolamine and its methyl and ethyl derivatives can also act as acceptors. EC 188.8.131.52.Sulfolobus: A genus of aerobic, chemolithotrophic, coccoid ARCHAEA whose organisms are thermoacidophilic. Its cells are highly irregular in shape, often lobed, but occasionally spherical. It has worldwide distribution with organisms isolated from hot acidic soils and water. Sulfur is used as an energy source.Rudiviridae: Family of rod-shaped DNA viruses infecting ARCHAEA. They lack viral envelopes or lipids.Fuselloviridae: A family of lemon-shaped DNA viruses infecting ARCHAEA and containing one genus: Fusellovirus.Receptors, Calcium-Sensing: A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.Lipothrixviridae: Family of enveloped, lipid-containing, filamentous DNA viruses that infect ARCHAEA.Gene Expression Regulation, Archaeal: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in archaea.Coxsackie and Adenovirus Receptor-Like Membrane Protein: An Ig superfamily transmembrane protein that localizes to junctional complexes that occur between ENDOTHELIAL CELLS and EPTHELIAL CELLS. The protein may play a role in cell-cell adhesion and is the primary site for the attachment of ADENOVIRUSES during infection.
Glycerol-3-phosphate dehydrogenase (NAD+)
1-alkenyl-2-acylglycerol choline phosphotransferase
For example, glycerophospholipids are composed of a glycerol backbone linked to one of approximately 10 possible headgroups and ... This involves the use of prepacked columns containing silica or other stationary phases to separate glycerophospholipids, fatty ... For example, NP-HPLC effectively separates glycerophospholipids on the basis of headgroup polarity, whereas RP-HPLC effectively ... "Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry". Meth. Enzymol. Methods in ...
Glycerophospholipid - Wikipedia
There are three major classes namely; 1-alkyl-2-acyl glycerophospholipid, 1,2-diacyl glycerophospholipid and plasmalogen. The ... The term glycerophospholipid signifies any derivative of glycerophosphoric acid that contains at least one O-acyl, or O-alkyl, ... Each glycerophospholipid molecule consists of a small polar head group and two long hydrophobic chains. In the cell membrane, ... Glycerophospholipids can also act as an emulsifying agent to promote dispersal of one substance into another. This is sometimes ...
Glycerophospholipid acyltransferase (CoA-dependent) - Wikipedia
Glycerophospholipid dictionary definition | glycerophospholipid defined
... plural glycerophospholipids) 1. (organic chemistry) Any phospholipid based on glycerol Origin From glycero- + phospho- + lipid ... "glycerophospholipid." YourDictionary, n.d. Web. 18 September 2018. ,http://www.yourdictionary.com/glycerophospholipid,. ... glycerophospholipid. (n.d.). Retrieved September 18th, 2018, from http://www.yourdictionary.com/glycerophospholipid ...
Intermembrane transport: Glycerophospholipid homeostasis of the Gram-negative cell envelope | PNAS
Intermembrane transport: Glycerophospholipid homeostasis of the Gram-negative cell envelope. Matthew J. Powers, M. Stephen ... Intermembrane transport: Glycerophospholipid homeostasis of the Gram-negative cell envelope. Matthew J. Powers, M. Stephen ... Intermembrane transport: Glycerophospholipid homeostasis of the Gram-negative cell envelope. Matthew J. Powers and M. Stephen ... Intermembrane transport: Glycerophospholipid homeostasis of the Gram-negative cell envelope Message Subject (Your Name) has ...
Glycerophosphoglycerophosphoglycerols (Cardiolipins) - Glycerophospholipids | Sigma-Aldrich
KEGG PATHWAY: Glycerophospholipid metabolism - Helicobacter pylori Aklavik86
Efficient and Specific Analysis of Red Blood Cell Glycerophospholipid Fatty Acid Composition
... between RBC phospholipids and glycerophospholipids. The analysis of RBC glycerophospholipid fatty acids yields faster, easier ... Aim We developed a method for the specific analysis of RBC glycerophospholipids. The application of the new method in a DHA ... Methods Methyl esters of glycerophospholipid fatty acids are selectively generated by a two step procedure involving methanolic ... Fatty acid status in RBC glycerophospholipids and other established markers were evaluated in thirteen subjects participating ...
Glycerophospholipids - DrugBank
Colfosceril palmitate is indicated for the treatment of respiratory distress syndrome (RDS) in premature infants. The official label is referred as a intratracheal suspension for prophylactic treatment of infants of less than 1350 grams of birth weight under risk of developing RDS, or in infants with birth weight greater than 1350 grams with pulmonary immaturity, or as rescue treatment of infants that already developed RDS.[L1109] The central feature of RDS is a surfactant deficiency due to lung immaturity. This lung condition is more frequently presented due to risk factors like prematurity, delayed lung maturation caused by maternal diabetes or male gender, or surfactant dysfuntion due to perinatal asphyxia, pulmonary infection or delivery without labor.[T70 ...
Glycerophospholipid | definition of Glycerophospholipid by Medical dictionary
What is Glycerophospholipid? Meaning of Glycerophospholipid medical term. What does Glycerophospholipid mean? ... Looking for online definition of Glycerophospholipid in the Medical Dictionary? Glycerophospholipid explanation free. ... redirected from Glycerophospholipid). Also found in: Wikipedia. phosphoglyceride. [fos″fo-glis´er-īd] a class of phospholipids ... For this glycerophospholipid, the OR between extreme tertiles was 0.. Untargeted metabolic profiling identifies altered serum ...
Glycerophospholipid Biosynthetic Pathway (Homo sapiens) - WikiPathways
... and in different types of glycerophospholipids in the same cell or tissue. In general, glycerophospholipids contain a saturated ... In glycerophospholipids, two fatty acids are ester-linked to glycerol at C-1 and C-2, and a highly polar or charged (and ... Ontology Term : glycerophospholipid metabolic pathway added !. 95594. view. 14:18, 5 January 2018. DeSl. Changed part of the ... Glycerophospholipids or phosphoglycerides, in which the hydrophobic regions are composed of two fatty acids joined to glycerol ...
Glycerophospholipid Biosynthetic Pathway (Homo sapiens) - WikiPathways
... and in different types of glycerophospholipids in the same cell or tissue. In general, glycerophospholipids contain a saturated ... Glycerophospholipid Biosynthetic Pathway (Homo sapiens). From WikiPathways. Revision as of 20:57, 20 July 2013 by Amanzo (Talk ... In glycerophospholipids, two fatty acids are ester-linked to glycerol at C-1 and C-2, and a highly polar or charged (and ... Ontology Term : glycerophospholipid metabolic pathway added !. 95594. view. 14:18, 5 January 2018. DeSl. Changed part of the ...
Italian cohort of patients affected by inflammatory bowel disease is characterised by variation in glycerophospholipid, free...
Choline and Ethanolamine Glycerophospholipids | Springer for Research & Development
Choline and ethanolamine glycerophospholipids are amphipathic molecules that are asymmetrically distributed in the bilayer. ... Outer Leaflet Neural Membrane Glycerophospholipid Metabolism Ethanolamine Glycerophospholipids Choline Phosphotransferase These ... and rearrangements of glycerophospholipids in membranes. Glycerophospholipids are a storage depot for precursors for second ... New perspectives on the regulation of intermembrane glycerophospholipid traffic. J Lipid Res 44: 441-449.PubMedGoogle Scholar ...
Molecules | Free Full-Text | OSBP-Related Proteins: Liganding by Glycerophospholipids Opens New Insight into Their Function
... and to play a role in the intracellular transport of this glycerophospholipid; Additionally, two mammalian ORPs were shown to ... OSBP-Related Proteins: Liganding by Glycerophospholipids Opens New Insight into Their Function. Vesa M. Olkkonen 1,2. ... Olkkonen, V.M. OSBP-Related Proteins: Liganding by Glycerophospholipids Opens New Insight into Their Function. Molecules 2013, ... "OSBP-Related Proteins: Liganding by Glycerophospholipids Opens New Insight into Their Function." Molecules 18, no. 11: 13666- ...
Glycerophospholipids in the Brain | Springer for Research & Development
Horrocks Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders provides ... Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders Akhlaq A. Farooqui and Lloyd A. ... Brain Disorder Farooqui Glycerophospholipids Horrocks Nervous System Neurological Phospholipase Authors and affiliations. * ... The information in Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders is presented in a lively manner ...
Fatty acid profiles of plasmalogen choline and ethanolamine glycerophospholipids in pig and rat hearts.
Glycerophospholipids | ENCOGNITIVE.COM
Glycerophospholipids. Changes in the Fatty Acid Composition of Brain and Liver Phospholipids from Rats Fed Fat-Free Diet Tagged ... Identification of glycerophospholipids in rapeseed, olive, almond, and sunflower oils by LC-MS and LC-MS-MS Tagged: * ... Glycerophospholipids enriched in docosahexaenoic acid (GPL-DHA) have been shown to regulate the (n-6)/(n-3) fa... ... Identification of Abundant Alkyl Ether Glycerophospholipids in the Human Lens by Tandem Mass Spectrometry Techniques Tagged: * ...
Glycerophospholipids and sphingolipids correlate with poor prognostic genotypes of human papillomavirus in cervical cancer:...
We identified glycerophospholipids and sphingolipids as the primary contributors for grouping. Furthermore, supported by cell ... Glycerophospholipids and sphingolipids correlate with poor prognostic genotypes of human papillomavirus in cervical cancer: ... Glycerophospholipids and sphingolipids correlate with poor prognostic genotypes of human papillomavirus in cervical cancer: ...
Figures and data in The Acinetobacter baumannii Mla system and glycerophospholipid transport to the outer membrane | eLife
Figures and data in The Acinetobacter baumannii Mla system and glycerophospholipid transport to the outer membrane | eLife
An Acinetobacter baumannii ABC transporter likely facilitates transport of glycerophospholipids from the inner to the outer ... Newly synthesized glycerophospholipids accumulate at the inner membrane of MlaA mutants.. (A) LC-MS/MS quantification of 13C ... Outer membrane glycerophospholipid levels are reduced in ∆mlaC mutant.. (A) Identification of inner and outer membrane ... Newly synthesized glycerophospholipids accumulate at the inner membrane of Mla mutants.. (A) LC-MS/MS quantification of 13C ...
GigaDB Dataset - DOI 10.5524/100341 - Supporting data for 'Lipidomics profiling reveals the role of glycerophospholipid...
The effect of low α-linolenic acid diet on glycerophospholipid molecular species in guinea pig brain<...
The effect of low α-linolenic acid diet on glycerophospholipid molecular species in guinea pig brain. / Kurvinen, J. P.; Kuksis ... Kurvinen JP, Kuksis A, Sinclair AJ, Abedin L, Kallio H. The effect of low α-linolenic acid diet on glycerophospholipid ... The changes in guinea pig brain (cerebrum) glycerophospholipid molecular species resulting from a low α-linolenic acid (ALA) ... N2 - The changes in guinea pig brain (cerebrum) glycerophospholipid molecular species resulting from a low α-linolenic acid ( ...
Glycerophospholipid metabolism - Yeast Metabolome Database
This project is supported by the Canadian Institutes of Health Research, Canada Foundation for Innovation, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Canada, Genome Alberta, and Genome British Columbia, a not-for-profit organization that is leading Canadas national genomics strategy with $900 million in funding from the federal government ...
Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the...
Furthermore, targeted RNA interference-mediated downregulation of candidate glycerophospholipid metabolism genes revealed a ... These results indicate that glycerophospholipid metabolism, and in particular phosphatidylcholine biosynthesis, plays an ... and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in ...
Reactome | Glycerophospholipid biosynthesis
Glycerophospholipids are first formed by the de novo (Kennedy) pathway using fatty acids activated as acyl-CoA donors. However ... Mechanisms of glycerophospholipid homeostasis in mammalian cells Hermansson, M, Hokynar, K, Somerharju, P ... Each glycerophospholipid is involved in acyl chain remodeling via cleavage by phospholipases followed by reacylation by an ... In addition, glycerophospholipids act as precursors of lipid mediators such as platelet-activating factor and eicosanoids. ...
Lipid - Wikipedia
The glycerophospholipids are the main structural component of biological membranes, as the cellular plasma membrane and the ... Examples of glycerophospholipids found in biological membranes are phosphatidylcholine (also known as PC, GPCho or lecithin), ... Glycerophospholipids, usually referred to as phospholipids (though sphingomyelins are also classified as phospholipids), are ... The formation of lipid bilayers is an energetically preferred process when the glycerophospholipids described above are in an ...
Glycerophospholipid metabolism. Left, glycerophospholip | Open-i
Left, glycerophospholipid synthesis; Right, glycerophospholipid degradation. The enzymes are choline kinase (ChoK), ... ijms-16-00924-f001: Glycerophospholipid metabolism. Left, glycerophospholipid synthesis; Right, glycerophospholipid degradation ... ijms-16-00924-f001: Glycerophospholipid metabolism. Left, glycerophospholipid synthesis; Right, glycerophospholipid degradation ... Mentions: Glycerophospholipids are the main component of biological membranes and contain at least one O-1-acyl, O-1-alkyl, or ...
Glycerophospholipid Synthesis Essay. Biochemistry: Lipid Metabolism
In Situ Structural Characterization of Glycerophospholipids and Sulfatides in Brain Tissue Using MALDI-MS/MS<...
In Situ Structural Characterization of Glycerophospholipids and Sulfatides in Brain Tissue Using MALDI-MS/MS. Journal of the ... Jackson, S. N., Wang, H. Y. J., & Woods, A. S. (2007). In Situ Structural Characterization of Glycerophospholipids and ... Jackson, Shelley N. ; Wang, Hay Yan J ; Woods, Amina S. / In Situ Structural Characterization of Glycerophospholipids and ... In Situ Structural Characterization of Glycerophospholipids and Sulfatides in Brain Tissue Using MALDI-MS/MS. / Jackson, ...
carS - CDP-archaeol synthase - Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) - carS gene & protein
MetabolismPathwaysEthanolaminePATHWAYPhosphatidic acidGlycerolPhospholipidsBiosynthesisCholinePlasmalogensCompositionForm a unique fingerprintMembraneSynthesisCholesteryl estersLinkagesCystic fibrosisLipid MediatorsReactionsSerumAmphipathicAcidMembranesCeramideHPLCSphingomyelinPhospholipaseStructuralBrain
- In addition, pathway analysis revealed that EGCG was involved in the regulation of the lipid and glucose metabolism, including insulin signaling pathway, Type II diabetes mellitus, glycerophospholipid metabolism, and adipocytokine signaling pathway. (thefreedictionary.com)
- The derivations of those biomarkers can be regulated by administration of XKS, which suggested that the intervention effect of XKS against AS may involve in regulating the lipid perturbation including fatty acid [beta]-oxidation pathway, sphingolipid metabolism, glycerophospholipid metabolism and bile acid biosynthesis. (thefreedictionary.com)
- Glycerophospholipids in Brain: Phospholipases A 2 in Neurological Disorders provides a synthesis of material on the metabolism of phospholipids in the brain which has previously only been available in a scattered number of original papers and reviews. (springer.com)
- Chen, X (2017): Supporting data for "Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis" GigaScience Database. (gigadb.org)
- Interestingly, many different bioactive lipid molecules, such as inositol trisphosphate, diacylglycerol, arachidonic acid, phosphatidic acid, and lysophosphatidic acid, are generated during glycerophospholipid metabolism, and these bioactive lipid molecules in turn regulate different signaling pathways in the cells [12, (nih.gov)
- This signature implies changes, mainly by down-regulation, in glycerolipid, glycerophospholipid and sphingolipid metabolism suggesting an altered biosynthetic pathway of glycerophospholipids and cell signaling as second messengers in women with PCOS. (udl.cat)
- Among its related pathways are Metabolism and Glycerophospholipid Biosynthetic Pathway . (genecards.org)
- The alkylacylglycerophospholipids are less abundant than the plasmalogens, e.g., about 59% of ethanolamine glycerophospholipids of human heart are plasmalogens, whereas only 3.6% are alkylacylglycerophospholipids. (wikipathways.org)
- However, in bovine erythrocytes, 75% of the ethanolamine glycerophospholipids are of alkylacyl type. (wikipathways.org)
- Choline and ethanolamine glycerophospholipids are amphipathic molecules that are asymmetrically distributed in the bilayer. (springer.com)
- Choline and ethanolamine glycerophospholipids are synthesized at the endoplasmic reticulum and are transported to other membranous structures by phospholipid exchange and transfer proteins. (springer.com)
- Fatty acid profiles of plasmalogen choline and ethanolamine glycerophospholipids in pig and rat hearts. (biomedsearch.com)
- This study examined the fatty acid composition of the choline and ethanolamine glycerophospholipids in pig heart and compared the results with those in rat heart. (biomedsearch.com)
- The presence of an additional head group (such as choline, ethanolamine, serine, inositol, and glycerol) attached to the phosphate allows for many different glycerophospholipids. (nih.gov)
- Glycerophospholipids are first formed by the de novo (Kennedy) pathway using fatty acids activated as acyl-CoA donors. (reactome.org)
- In the de novo pathway of glycerophospholipid biosynthesis, lysophosphatidic acid (LPA) is initially formed from glycerol 3-phosphate (G3P). (reactome.org)
- The AGPAT2 enzyme is part of a chemical pathway in many cells that produces two important types of fats (lipids): glycerophospholipids and triacylglycerols. (medlineplus.gov)
- Cellular membranes contains a distinct composition of various glycerophospholipids such as phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidylinositol (PI), cardiolipin (CL), lysophosphatidic acid (LPA) and lysobisphosphatidic acid (also known as bis(monoacylglycerol) hydrogen phosphate - BMP). (reactome.org)
- Additional reactions convert phosphatidic acid to glycerophospholipids and triacylglycerols. (medlineplus.gov)
- Glycerophospholipids or phosphoglycerides are glycerol-based phospholipids. (wikipedia.org)
- The term glycerophospholipid signifies any derivative of glycerophosphoric acid that contains at least one O-acyl, or O-alkyl, or O-alk-1'- enyl residue attached to the glycerol moiety. (wikipedia.org)
- In glycerophospholipids, two fatty acids are ester-linked to glycerol at C-1 and C-2, and a highly polar or charged (and therefore hydrophilic) head group is attached to C-3 through a phosphodiester bond. (wikipathways.org)
- These lipids differ from conventional glycerophospholipids in that the sn-1 substituent is attached to the glycerol backbone via an 1-O-alkyl or an 1-O-alk-1'-enyl ether rather than an ester bond. (encognitive.com)
- Glycerophospholipids are the main component of biological membranes and contain at least one O-1-acyl, O-1-alkyl, or O-1-alkenyl residue attached to the glycerol moiety. (nih.gov)
- Den midterste struktur er en triglycerid bestående af oleoyl -, stearoyl - og palmitoyl -kæder hæftet på en glycerol -rygrad. (wikipedia.org)
- High correlations were observed for most of the mono- and polyunsaturated fatty acids, and for the omega-3 index (r = 0.924) between RBC phospholipids and glycerophospholipids. (plos.org)
- The analysis of RBC glycerophospholipid fatty acids yields faster, easier and less costly results equivalent to the conventional analysis of RBC total phospholipids. (plos.org)
- Eukaryotic membranes contain significant amounts of two other types of glycerophospholipids: Plasmalogens and Alkylacylglycerophospholipids. (wikipathways.org)
- About 20% of mammalian glycerophospholipids are plasmalogens, this percentage varies both from species to species and from tissue to tissue within a given organism. (wikipathways.org)
- The special glycerophospholipids plasmalogens (Pls) are enriched in the brain and reported to prevent neuronal cell death by enhancing phosphorylation of Akt and ERK signaling in neuronal cells. (clarkfrancis.com)
- Introduction Plasmalogens (Pls), JTC-801 which are glycerophospholipids characterized by the presence of vinyl ether linkage at the position, are enriched in the central anxious program [1, (clarkfrancis.com)
- Klem S, Klingler M, Demmelmair H, Koletzko B (2012) Efficient and Specific Analysis of Red Blood Cell Glycerophospholipid Fatty Acid Composition. (plos.org)
- Effects of salinity on the fatty acid composition of total lipid and individual glycerophospholipid classes of Atlantic salmon (Salmo salar) and turbot (Scopthalmus maximus) cells in culture. (thefreedictionary.com)
- Subsequent acyl chain remodeling (Lands cycle) generates the diverse glycerophospholipid composition and asymmetry characteristic of cell membranes. (reactome.org)
- Output: possible oxidized glycerophospholipid chain-composition masses, with various annotations, including predicted product ions. (lipidmaps.org)
- FA composition was assessed in serum glycerophospholipids. (ufz.de)
Form a unique fingerprint1
- The cell membrane seen under the electron microscope consists of two identifiable layers, or "leaflets", each of which is made up of an ordered row of glycerophospholipid molecules. (wikipedia.org)
- While the initial discovery and subsequent studies have posited that it mediated retrograde lipid transport (removing glycerophospholipids from the outer membrane and returning them to the inner membrane), others have asserted the opposite. (pnas.org)
- The degree of saturation and the length of glycerophospholipid-acyl chains are important determinants of neural membrane properties. (springer.com)
- Glycerophospholipids are a storage depot for precursors for second messengers, and may be involved in membrane fusion, apoptosis, and regulation of the activities of membrane-bound enzymes and ion-channels. (springer.com)
- Since the most of the glycerophospholipids are found in all membrane compartments, there must be extensive network of transport of glycerophospholipids from one membrane compartment to another via various mechanisms including diffusion through the cytosol, formation of transportation complexes, and diffusion via membrane contact sites (MCS) (Osman et al. (reactome.org)
- Site-directed mutagenesis and molecular dynamics simulations further revealed a built-in motif allowing en bloc insertion of the fusion loop into membranes, making few nonpolar side-chain interactions with the aliphatic moiety and multiple polar interactions with lipid head groups upon membrane restructuring. (uni-saarland.de)
- A lack of enzyme activity may also reduce the levels of glycerophospholipids in adipocytes, which changes the structure of the cell membrane and disrupts normal signaling within these cells. (medlineplus.gov)
- Determinants of Serum Glycerophospholipid Fatty Acids in Cystic Fibrosis. (cdc.gov)
- Glycerophospholipids undergo base-exchange, methylation, and decarboxylation reactions for interconversion. (springer.com)
- These reactions and activities of phospholipases A 2 , C, and D are involved in the turnover, compositional maintenance, and rearrangements of glycerophospholipids in membranes. (springer.com)
- Glycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. (reactome.org)
- We aimed to investigate the determinants of serum glycerophospholipids' FAs in CF with regard to the highest number of FAs and in the largest cohort to date. (cdc.gov)
- Fatty acid status in RBC glycerophospholipids and other established markers were evaluated in thirteen subjects participating in a 30 days supplementation trial (510 mg DHA/d). (plos.org)
- In general, glycerophospholipids contain a saturated fatty acid at C-1 and an unsaturated fatty acid at C-2, and, in general terms, the fatty acyl groups are generally 16 or 18 carbons long. (wikipathways.org)
- Glycerophospholipids enriched in docosahexaenoic acid (GPL-DHA) have been shown to regulate the (n-6)/(n-3) fa. (encognitive.com)
- One of the main functions of glycerophospholipid is to serve as a structural component of biological membranes. (wikipedia.org)
- Most of the glycerophospholipids are synthesized at the endoplasmic reticulum (ER), however, some, most notably cardiolipin, and BMP are synthesized in the mitochondrial and endosomal membranes respectively. (reactome.org)
- Glycerophospholipids are the major component of cell membranes and are involved in chemical signaling within cells. (medlineplus.gov)
- This paper describes the use of positive and negative ion electrospray mass spectrometry (MS) and MS/MS (tandem mass spectrometry) to identify glycerophospholipid and ceramide headgroups and their alkyl, alkenyl and acyl constituents. (montclair.edu)
- The liposome is composed of ceramide, cholesterol, and the glycerophospholipid POPC. (the-scientist.com)
- By means of UPLC/MS technology, we found in a previous study that there are significant changes between the phospholipid levels of AMI patients before I/R treatment compared to healthy controls - specifically, glycerophospholipid is significantly down-regulated and most sphingomyelin are up-regulated. (thefreedictionary.com)
- In Situ Structural Characterization of Glycerophospholipids and Sulfatides in Brain Tissue Using MALDI-MS/MS . Journal of the American Society for Mass Spectrometry , 18 (1), 17-26. (elsevier.com)
- Jackson, SN, Wang, HYJ & Woods, AS 2007, ' In Situ Structural Characterization of Glycerophospholipids and Sulfatides in Brain Tissue Using MALDI-MS/MS ', Journal of the American Society for Mass Spectrometry , vol. 18, no. 1, pp. 17-26. (elsevier.com)
- General structural formula of a glycerophospholipid. (britannica.com)