Derivatives of GLUCURONIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the 6-carboxy glucose structure.
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
A colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables. Also, it is an active ingredient in certain oral sedatives and topical anesthetics.
A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression.
A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.
A 5-carbon keto sugar.
The decarboxylation product of UDPglucuronic acid, which is used for formation of the xylosides of seryl hydroxyl groups in mucoprotein synthesis. Also forms plant xylans.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones.
An enzyme that catalyzes the oxidation of UDPglucose to UDPglucuronate in the presence of NAD+. EC 1.1.1.22.
Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
A species of the fungus CRYPTOCOCCUS. Its teleomorph is Filobasidiella neoformans.
The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium.
Infection with a fungus of the species CRYPTOCOCCUS NEOFORMANS.
Polysaccharides found in bacteria and in capsules thereof.
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Minute intercellular channels that occur between liver cells and carry bile towards interlobar bile ducts. Also called bile capillaries.
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The interactions between physician and patient.
Those individuals engaged in research.
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
A species of gram-negative, aerobic rods formerly called Pseudomonas testosteroni. It is differentiated from other Comamonas species by its ability to assimilate testosterone and to utilize phenylacetate or maleate as carbon sources.
Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
An antiseptic and disinfectant aromatic alcohol.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)
Procedures for the improvement or enhancement of the appearance of the visible parts of the body.
Organic siloxanes which are polymerized to the oily stage. The oils have low surface tension and density less than 1. They are used in industrial applications and in the treatment of retinal detachment, complicated by proliferative vitreoretinopathy.
Localized hyperplasia of the horny layer of the epidermis due to pressure or friction. (Dorland, 27th ed)
Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation.
The process that reverts CELL NUCLEI of fully differentiated somatic cells to a pluripotent or totipotent state. This process can be achieved to a certain extent by NUCLEAR TRANSFER TECHNIQUES, such as fusing somatic cell nuclei with enucleated pluripotent embryonic stem cells or enucleated totipotent oocytes. GENE EXPRESSION PROFILING of the fused hybrid cells is used to determine the degree of reprogramming. Dramatic results of nuclear reprogramming include the generation of cloned mammals, such as Dolly the sheep in 1997.
A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
The segment of GASTROINTESTINAL TRACT that includes the small intestine below the DUODENUM, and the LARGE INTESTINE.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.

Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations. (1/804)

Daidzein and genistein glucuronides (DG and GG), major isoflavone metabolites, may be partly responsible for biological effects of isoflavones, such as estrogen receptor binding and natural killer cell (NK) activation or inhibition. DG and GG were synthesized using 3-methylcholanthrene-induced rat liver microsomes. The Km and Vmax for daidzein and genistein were 9.0 and 7.7 micromol/L, and 0.7 and 1.6 micromol/(mg protein. min), respectively. The absence of ultraviolet absorbance maxima shifts in the presence of sodium acetate confirmed that the synthesized products were 7-O-glucuronides. DG and GG were further purified by a Sephadex LH-20 column. DG and GG competed with the binding of 17beta-(3H) estradiol to estrogen receptors of B6D2F1 mouse uterine cytosol. The concentrations required for 50% displacement of 17beta-(3H) estradiol (CB50) were: 17beta-estradiol, 1.34 nmol/L; diethylstilbestrol, 1.46 nmol/L; daidzein, 1.6 micromol/L; DG, 14.7 micromol/L; genistein, 0.154 micromol/L; GG, 7.27 micromol/L. In human peripheral blood NK cells, genistein at <0.5 micromol/L and DG and GG at 0.1-10 micromol/L enhanced NK cell-mediated K562 cancer cell killing significantly (P < 0.05). At > 0.5 micromol/L, genistein inhibited NK cytotoxicity significantly (P < 0.05). The glucuronides only inhibited NK cytotoxicity at 50 micromol/L. Isoflavones, and especially the isoflavone glucuronides, enhanced activation of NK cells by interleukin-2 (IL-2), additively. At physiological concentrations, DG and GG were weakly estrogenic, and they activated human NK cells in nutritionally relevant concentrations in vitro, probably at a site different from IL-2 action.  (+info)

Identification of cis-9,10-methylenehexadecanoic acid in submitochondrial particles of bovine heart. (2/804)

Submitochondrial particles of bovine heart were hydrolyzed by phospholipase A2 and the products were analyzed by liquid chromatography electrospray ionization-mass spectrometry. We found a fatty acid with a molecular mass of 268 Da and a retention time longer than that of linoleic acid. Next, we synthesized organically cis-9,10-methylenehexadecanoic acid, which has a molecular mass similar to that of the extracted fatty acid, and characterized its high performance liquid chromatography and gas chromatography-mass spectrometry profiles. Using these data we were able to identify endogenous cis-9,10-methylenehexadecanoic acid in rat and human heart and liver tissues that had been hydrolyzed by phospholipase A2. This fatty acid was not detected in tissue extracts that had not been hydrolyzed by phospholipase A2. Similar amounts of cis-9, 10-methylenehexadecanoic acid were measured in tissue extracts after total hydrolysis. These results suggest that cis-9, 10-methylenehexadecanoic acid is a fatty acid component, in the sn-2 position, of phospholipids in some mammalian tissue.  (+info)

Metabolites of a tobacco-specific carcinogen in urine from newborns. (3/804)

BACKGROUND: Cigarette smoking during pregnancy can result in fetal exposure to carcinogens that are transferred from the mother via the placenta, but little information is available on fetal uptake of such compounds. We analyzed samples of the first urine from newborns whose mothers did or did not smoke cigarettes for the presence of metabolites of the potent tobacco-specific transplacental carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). METHODS: The urine was collected and analyzed for two metabolites of NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronide (NNAL-Gluc). Gas chromatography and nitrosamine-selective detection, with confirmation by mass spectrometry, were used in the analyses, which were performed without knowledge of the origin of the urine samples. RESULTS: NNAL-Gluc was detected in 22 (71%) of 31 urine samples from newborns of mothers who smoked; NNAL was detected in four of these 31 urine samples. Neither compound was detected in the 17 urine samples from newborns of mothers who did not smoke. The arithmetic mean level of NNAL plus NNAL-Gluc in the 27 newborns of smokers for which both analytes were quantified was 0.14 (95% confidence interval [CI] = 0.083-0.200) pmol/mL. The levels of NNAL plus NNAL-Gluc in the urine from these babies were statistically significantly higher than those in the urine from newborns of nonsmoking mothers (geometric means = 0.062 [95% CI = 0.035-0.110] and 0.010 [considered as not detected; no confidence interval], respectively; two-sided P<.001). NNAL plus NNAL-Gluc levels in the 18 positive urine samples in which both analytes were quantified ranged from 0.045 to 0.400 pmol/mL, with an arithmetic mean level of 0.20 (95% CI = 0.14-0.26) pmol/mL, about 5%-10% of the levels of these compounds detected in the urine from adult smokers. CONCLUSIONS: Two metabolites of the tobacco-specific transplacental carcinogen NNK can be detected in the urine from newborns of mothers who smoked cigarettes during pregnancy.  (+info)

Ethyl glucuronide--a marker of alcohol consumption and a relapse marker with clinical and forensic implications. (4/804)

Ethyl glucuronide (EtG) is a non-volatile, water-soluble, direct metabolite of ethanol that can be detected in body fluids and hair. We investigated urine and serum samples from three patient groups: (1) 33 in-patients in acute alcohol withdrawal; (2) 30 detoxified in-patients (treated for at least 4 weeks) from a 'motivation station'; and (3) 43 neuro-rehabilitation patients (non-alcoholics; most of them suffering from stroke, traumatic brain injury, Parkinson's disease etc.) using gas chromatography/mass spectrometry (GC/MS) with deuterium-labelled EtG as the internal standard and additionally in the second group of patients using liquid chromatography (LC/MS-MS). We found no correlation between the concentration of EtG in urine at hospitalization and the blood-ethanol concentration (r = 0.17), the time frame of detection (r = 0.5) or the total amount of clomethiazole required for the treatment of withdrawal symptoms (r = 0.28). In four out of 30 in-patients from the 'motivation station'--where neither clinical impression nor routine laboratory findings gave indications of relapse--concentrations of EtG in urine ranged between 4.2 and 196.6 mg/l. EtG concentrations in urine of between 2.89 and 23.49 mg/l were found in seven out of 43 neuro-rehabilitation patients using GC/MS. The GC/MS and the LC/MS-MS results showed a correlation of 0.98 with Pearson's correlation test and 1.0 with Spearman's correlation test. We suggest that EtG is a marker of alcohol consumption that can be detected for an extended time period after the complete elimination of alcohol from the body. When used as a relapse marker with a specific time frame of detection intermediate between short- and long-term markers, EtG fills a clinically as well as forensically important gap. Its specificity and sensitivity exceed those of all other known ethanol markers.  (+info)

Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: evidence for endoperoxide bioactivation. (5/804)

Ro 42-1611 (arteflene) is a synthetic endoperoxide antimalarial. The antimalarial activity of endoperoxides is attributed to iron(II)-mediated generation of carbon-centered radicals. An alpha, beta-unsaturated ketone (enone; 4-[2',4' bis(trifluoromethyl)phenyl]-3-buten-2-one), obtained from arteflene by reaction with iron(II), was identified previously as the stable product of a reaction that, by inference, also yields a cyclohexyl radical. The activation of arteflene in vivo has been characterized with particular reference to enone formation. [14C]Arteflene (35 micromol/kg) was given i.v. to anesthetized and cannulated male rats: 42.2 +/- 7.0% (mean +/- S.D., n = 7) of the radiolabel was recovered in bile over 5 h. In the majority of rats, the principal biliary metabolites were 8-hydroxyarteflene glucuronide (14.2 +/- 3. 9% dose, 0-3 h) and the cis and trans isomers of the enone (13.5 +/- 4.6% dose, 0-3 h). In conscious rats, 15.3 +/- 1.6% (mean +/- S.D., n = 8) of the radiolabel was recovered in urine over 24 h. The principal urinary metabolite appeared to be a glycine conjugate of a derivative of the enone. Biliary excretion of the glucuronide, but not of the enones, was inhibited by ketoconazole. 8-Hydroxyarteflene was formed extensively by rat and human liver microsomes but no enone was found. Bioactivation is a major pathway of arteflene's metabolism in the rat. Although the mechanism of in vivo bioactivation is unclear, the reaction is not catalyzed by microsomal cytochrome P-450 enzymes.  (+info)

Purification and properties of an alginate lyase from a marine bacterium. (6/804)

An unidentified pseudomonad isolated by enrichment procedures from decomposing seaweed was grown in defined medium containing sodium alginate as the sole carbon source. The alginate lyase recovered from disrupted bacterial cells was purified by a procedure of (NH4)2SO4 precipitation, gel filtration and ion-exchange chromatography. From sodium dodecyl sulphate/polyacrylamide-gel-electrophoresis experiments a mol.wt. of about 50 000 was determined. The enzyme was active against both algal and bacterial alginate preparations. Kinetic studies together with analysis of the unsaturated oligouronide products of alginate lyase action indicated the enzyme was specific for guluronic acid-containing regions of the macromolecular substrate. The specificity of the enzyme can be used to give information about the primary composition of alginate samples.  (+info)

Structural elucidation of a novel exopolysaccharide produced by a mucoid clinical isolate of Burkholderia cepacia. Characterization of a trisubstituted glucuronic acid residue in a heptasaccharide repeating unit. (7/804)

The structure of the exopolysaccharide (EPS) produced by a clinical isolate of Burkholderia cepacia isolated from a patient with fibrocystic lung disease has been investigated. By means of methylation analyses, carboxyl reduction, partial depolymerization by fuming HCl and chemical degradations such as Smith degradation, lithiumethylenediamine degradation and beta-elimination, supported by GC/MS and NMR spectroscopic analyses, the repeat unit of the EPS has been identified and was shown to correspond to the acidic branched heptasaccharide with the following structure: [formula: see text]. This partially acetylated acidic polymer, distinguished by the presence of the less usual D-isomer of rhamnose and of a trisubstituted glucuronic acid residue, could represent the main EPS produced by this bacterial species.  (+info)

Biotransformation of curcumin through reduction and glucuronidation in mice. (8/804)

Curcumin, the yellow pigment in turmeric and curry, has antioxidative and anticarcinogenic activities. In this study, we investigated the pharmacokinetic properties of curcumin in mice. After i.p. administration of curcumin (0.1 g/kg) to mice, about 2.25 microg/ml of curcumin appeared in the plasma in the first 15 min. One hour after administration, the levels of curcumin in the intestines, spleen, liver, and kidneys were 177.04, 26.06, 26.90, and 7.51 microg/g, respectively. Only traces (0.41 microg/g) were observed in the brain at 1 h. To clarify the nature of the metabolites of curcumin, the plasma was analyzed by reversed-phase HPLC, and two putative conjugates were observed. Treatment of the plasma with beta-glucuronidase resulted in a decrease in the concentrations of these two putative conjugates and the concomitant appearance of tetrahydrocurcumin (THC) and curcumin, respectively. To investigate the nature of these glucuronide conjugates in vivo, the plasma was analyzed by electrospray. The chemical structures of these metabolites, determined by mass spectrometry/mass spectrometry analysis, suggested that curcumin was first biotransformed to dihydrocurcumin and THC and that these compounds subsequently were converted to monoglucuronide conjugates. Because THC is one of the major metabolites of curcumin, we studied its stability at different pH values. THC was very stable in 0.1 M phosphate buffers of various pH values. Moreover, THC was more stable than curcumin in 0.1 M phosphate buffer, pH 7.2 (37 degrees C). These results, together with previous findings, suggest that curcumin-glucuronoside, dihydrocurcumin-glucuronoside, THC-glucuronoside, and THC are major metabolites of curcumin in vivo.  (+info)

In female zebrafish ovulation could be induced by male holding water, testis homogenates, and testis fractions containing steroid glucuronides. Deglucuronidation of these fractions led to a loss of ovulation-inducing potency, indicating steroid glucuronides as ovulation inducers. The chemical substances were perceived by the recipient females by means of olfaction. Incubation ... read more experiments showed the capacity of the testes to synthesize various C19 and C21 steroids and seven different steroid glucuronides, i.e., 17α,20β-dihydroxy-4-pregnen-3-one-, testosterone-, androsterone-, epiandrosterone-, 5α-androstane-3α,17β-diol-, and 5α-androstane-3β,17β-diol glucuronide. GC-MS analysis showed the presence of glucuronides of 5α-androstane-3α,17β-diol and cholesterol in male holding water, the latter probably originating from the liver. These compounds may be among the steroid glucuronides functioning as ovulation-inducing pheromones. show less ...
Background: Alcohol consumption is a frequently studied risk factor for chronic diseases, but many studies are hampered by self-report of alcohol consumption. The urinary metabolite ethyl glucuronide (EtG), reflecting alcohol consumption during the past 72 h, is a promising objective marker, but population data are lacking.. Objective: The objective of this study was to assess the reliability of EtG as a marker for habitual alcohol consumption compared with self-report and other biomarkers in the general population.. Methods: Among 6211 participants in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort, EtG concentrations were measured in 24-h urine samples. EtG was considered positive when concentrations were ,= 100 ng/mL. Habitual alcohol consumption was self-reported by questionnaire (categories: no/almost never, 1-4 units per month, 2-7 units per week, 1-3 units per day or ,= 4 units per day). Plasma HDL cholesterol concentration, erythrocyte mean corpuscular volume ...
Biotage Announces an Easy, Cost-Effective Approach to the Analysis of Ethyl Glucuronide (EtG) in Urine for Clinical and Forensic Toxicology Laboratories. Uppsala, Sweden - Biotage® (STO: BIOT), a leading supplier of tools and technology for analytical and medicinal chemistry, introduced a new sample preparation application note for the extraction of ethyl glucuronide from urine by LC-MS.. EtG can be detected at very low levels and being a metabolite it is useful in distinguishing between ingested ethanol and that which is absorbed through the skin from ethanol containing products such as alcohol based hand washes. Rapid and reliable methods with robust extraction protocols are essential for analysis and quantitation of EtG from various matrices.. Advances in the manufacture of polymeric stationary phases and the recent release of EVOLUTE® AX, a mixed-mode ion exchange product, have allowed for the development of a more robust, cost-effective procedure. The protocol was developed on 96-well ...
Shop the best Swanson Rejuv Glucuronolactone Energy Formula 60 Veg Caps products at Swanson Health Products. Trusted since 1969, we offer trusted quality and great value on Swanson Rejuv Glucuronolactone Energy Formula 60 Veg Caps products.
The direct alcohol marker ethyl glucuronide (EtG) is widely used for the assessment of alcohol consumption behavior and abstinence monitoring by hair analysis.
Ethyl Glucuronide, aka EtG is the best way to effectively monitor alcohol abstinence. No one would argue that the number one abused substance in America is alcohol. There are many ways to detect alcohol consumption, and breathalyzers are a wonderful tool in corrections for detecting someone under the influence. However, for those who encourage and monitor abstinence of alcohol, detecting its use after only a few hours had been extremely difficult. Negative breathalyzer readings, and traditional ethanol alcohol tests do not necessarily indicate abstinence.
AMH Nationwide offers hair alcohol tests by ethyl glucuronide (ETG). Call us at ☎ (888) 493-2521 to find more information about a lab near you!
ARE THEY DRINKING? WELL FIND OUT.. Pinnacle Health Technologies (PHT) offers ethyl glucuronide (EtG) and ethyl sulfate (EtS) testing, known as the EtG/EtS Alcohol Testing solution. EtG is a direct metabolite of alcohol ethanol). Its presence in urine may be used to detect recent alcohol ingestion, even after ethanol is no longer measurable. The presence of EtG in urine is an indicator that alcohol was ingested. EtG is detectable in urine for up to 80 hours after the consumption of alcohol. EtG is only evident when alcohol is ingested and is not produced as a result of fermentation. In addition to EtG, recent scientific studies have identified ethyl sulfate (EtS) as a second specific metabolite or biomarker of ethanol. For this reason, PHT tests and reports EtS, in conjunction with EtG, to confirm recent ethanol ingestion or exposure. The detection of EtG and EtS offers greater sensitivity and accuracy for determination of recent alcohol ingestion, than by detection of either biomarker alone. ...
NM Di Filippo, HJ Blumenthal. Experimental cholelithiasis in the golden hamster: effect of glucuronolactone. J Am Osteopath Assoc 1972;72(3):288. doi: .. Download citation file:. ...
Ethyl glucuronide (EtG) is a minor metabolite of alcohol that can be detected in hair. The objective of this study was to develop a validated method for the detection of EtG in hair samples. In addition, the research evaluated whether the level of ethyl glucuronide in hair can distinguish excessive v. social use of alcohol. Samples were collected from individuals who self-reported their daily or weekly consumption of alcohol. The hair samples were extracted and analyzed by GC-MS-MS. This study successfully developed a method to detect EtG in hair. EtG can be detected in concentrations from 1 pg/mg to 2 ng/mg. However, it was not possible to determine whether a correlation exists between a patients self-reported drinking history and the EtG concentrations found in their hair. Further research is needed to refine the extraction method ...
2017. McDonell MG, Leickly E, McPherson S, Skalisky J, Srebnik S, Angelo F, Vilardaga R, Nepom JR, Roll JM, Ries RK. A randomized controlled trial of ethyl glucuronide-based contingency management for outpatients with co-occurring alcohol use disorders and serious mental illness. Am J Psychiatry. 2017; 174 (4): 370-377. PMCID: PMC5378651.. McDonell MG, Leickly E, McPherson S, Skalisky J, Hirchak K, Oluwoye O, Srebnik D, Roll JM, Richard RK. Pretreatment ethyl glucuronide levels predict response to a contingency management intervention for alcohol use disorders with serious mental illness. Am J Addict. 2017; 26(7):673-675. PMCID: PMC5610611.. Leickly E, Skalisky J, McPherson S, Orr MF, McDonell MG. High agreement between benchtop and point-of-care dipcard tests for ethyl glucuronide. Ther Drug Monit. 2017; 39(4):461-462. PMCID: PMC5513150.. ​. 2015. ​. McDonell MG, Skalisky J, Leickly E, McPherson S, Battalio S, Nepom JR, Srebnik D, Roll J, Ries RK. Using ethyl glucuronide in urine to detect ...
It is a typical observe within the cosmetics trade, particularly within the case of the main producers, to take care of costs down by using solely in all probability the most worth efficient ingredients potential. That is the way in which by which that these corporations guarantee their merchandise have the perfect doable profit margin. This follow could also be helpful to them, nonetheless its detrimental to their customers. Whats a EtG alcohol testing ? An EtG, or ethyl glucuronide test will likely be preformed by quite a few means; two specifically are urine alcohol testing and hair alcohol testing. An EtG verify detected by way of urine samples, or with scalp hair samples, take a look at the presence of EtG within the form of a biomarker. EtG or Ethyl glucuronide is a metabolite solely produced when alcohol is within the bloodstream. The extra alcohol an individual consumes, the larger quantity of EtG markers are current in the hair or urine pattern. There are a number of differences ...
ETG drug testing dip kits can be purchased here at Medical Distribution Group for a competitive price. Order online or give us a call today.
Liquid urine controls are designed to monitor the performance with Immunoassay analyzers . Designed to match most testing cutoff levels on the market by leading Immunoassay companies such as Siemens, Roche, Danaher (Beckman) and Abbott. Our formulations are updated as market changes and new testing reagents become avai
These incredibly accurate saliva based drug tests are pefect for any job site or corporate setting. Less invasive that traditional urine tests, these tests are quick to read and dependable.
These incredibly accurate saliva based drug tests are pefect for any job site or corporate setting. Less invasive that traditional urine tests, these tests are quick to read and dependable.
Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) are unique biomarkers of alcohol use. EtG and EtS analysis offers many advantages for abstinence monitoring including the detection window, stability in stored specimens, and specificity. EtG and EtS are both polar, making them difficult to retain via reversed-phase chromatography. Both compounds are also very sensitive to matrix interferences which can result in being unable to achieve low limits of detection and can also make quantitation impossible. In this study, a simple dilute and shoot method was developed and validated for the analysis of EtG and EtS in human urine by LC-MS/MS ...
PMID 16864595] The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. ...
14 Panel|br /| 25 per box|br /| Tests for:Amphetamines - AMP, Barbiturates - BAR, Buprenorphine - BUP, Benzodiazepines - BZO, Cocaine - COC, Ethyl Glucuronide - ETG, Fentanyl - FEN, Methamphetamine - MAMP, Ecstacy - MDMA, Methadone - MTD, Morphine - MOP, Oxycodone - OXY, Phencyclidine - PCP, Marijuana - THC
The human UDP glycosyltransferase (UGT) 3A family is one of three families involved in the metabolism of small lipophilic compounds. Members of these families catalyze the addition of sugar residues to chemicals, which enhances their excretion from the body. The UGT1 and UGT2 family members primarily use UDP glucuronic acid to glucuronidate numerous compounds, such as steroids, bile acids, and therapeutic drugs. We showed recently that UGT3A1, the first member of the UGT3 family to be characterized, is unusual in using UDP N-acetylglucosamine as sugar donor, rather than UDP glucuronic acid or other UDP sugar nucleotides (J Biol Chem 283:36205-36210, 2008). Here, we report the cloning, expression, and characterization of UGT3A2, the second member of the UGT3 family. Like UGT3A1, UGT3A2 is inactive with UDP glucuronic acid as sugar donor. However, in contrast to UGT3A1, UGT3A2 uses both UDP glucose and UDP xylose but not UDP N-acetylglucosamine to glycosidate a broad range of substrates including ...
Johnson-Davis KL, Slawson MH. Ethyl Glucuronide Positivity Rate in a Pain Management Population. J Anal Toxicol. 2015; 39 (9): 686-90.
4-O-Substituted D-glucuronic acid derivatives were synthesized from D-glucose in order to study the regioselectivity of sulfation.
glucuronide: Any of various derivatives of glucuronic acid formed during the metabolism of phenols etc that serve to remove them from the bloodstream
said: You start to count your hours from the time your BAC is zero. You will produce ETG until your BAC is zero. If you can get at least 72 hours, you have a fairly good chance of passing. Hydrate early on after the drinking, then urinate one last time prior to your test to remove any ETG left in your bladder if there is any. You would be much safer to have at least 96 hours after a zero BAC ...
2246380-69-6, MAC glucuronide phenol-linked SN-38, MF: C₅₀H₅₄N₆O₂₀S, MW: [1091.06], Purity: ≥95%, Quantity: 10mg-1g. Supplier with competitive price $., 2246380-69-6, MAC glucuronide phenol-linked SN-38, ADCs-T0110
Dr. Trudy Nwachukwu is a third year Periodontics Resident at the University of Manitoba. She received her Bachelors degree in Dental Surgery( 2004) from the University of Benin, Nigeria. She practiced general dentistry in Dublin, Ireland before completing a Diploma in Postgraduate Dental Studies (2011) from the University of Bristol, United Kingdom and a Masters degree in Dental Public Health(2012) at the University of Manchester, United Kingdom. She is a member of the Royal College of Surgeons, Ireland and a member of the Canadian and American Academy of Periodontology.. ...
TY - JOUR. T1 - A novel pathway for fungal D-glucuronate catabolism contains an L-idonate forming 2-keto-L-gulonate reductase. AU - Kuivanen, Joosu. AU - Sugai-Guérios, Maura Harumi. AU - Arvas, Mikko. AU - Richard, Peter. PY - 2016. Y1 - 2016. N2 - For the catabolism of D-glucuronate, different pathways are used by different life forms. The pathways in bacteria and animals are established, however, a fungal pathway has not been described. In this communication, we describe an enzyme that is essential for D-glucuronate catabolism in the filamentous fungus Aspergillus niger. The enzyme has an NADH dependent 2-keto-L-gulonate reductase activity forming L-idonate. The deletion of the corresponding gene, the gluC, results in a phenotype of no growth on D-glucuronate. The open reading frame of the A. niger 2-keto-L-gulonate reductase was expressed as an active protein in the yeast Saccharomyces cerevisiae. A histidine tagged protein was purified and it was demonstrated that the enzyme converts ...
1. The fate of sulphadimethoxine (2,4-dimethoxy-6-sulphanilamidopyrimidine) was studied in man, rhesus monkey, dog, rat, guinea pig and rabbit. 2. About 20-46% of the dose (0·1g./kg.) of the drug is excreted in the urine in 24hr. in these species, except the rat, in which only 13% is excreted. 3. In man and the monkey sulphadimethoxine N1-glucuronide is the major metabolite in the urine. In the rabbit and guinea pig N4-acetylsulphadimethoxine is the main metabolite. In the dog the drug is excreted mainly unchanged. In the rat equal amounts of the unchanged drug and its N4-acetyl derivative are the main products. 4. Small amounts of sulphadimethoxine N4-glucuronide are found in the urine of all the species. Sulphadimethoxine N1-glucuronide occurs in small amounts in the urine of rat, dog and guinea pig; none is found in rabbit urine. 5. Sulphadimethoxine N4-sulphate was synthesized and found to occur in small amounts in rat urine. 6. Monkey liver homogenates fortified with UDP-glucuronic acid ...
Glucuronolactone Review, Benefits, Effects, Uses, Side Effects and Dosages. What is this Red Bull Energy Drink ingredient used for and how does it work?
Incidence and mortality rates for lung cancer in the United States are significantly greater in blacks than in whites. This disparity cannot be explained by differences in smoking behavior. We hypothesize that the observed racial differences in risk may be due to differences in the metabolic activation or detoxification of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). To test this, different biomarkers of NNK exposure and metabolism, including the urinary metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and the presumed detoxification product [4-(methylnitrosamino)-1-(3-pyridyl)but-1-yl]-beta-O-D-glucosiduronic acid (NNAL-Gluc), were examined along with questionnaire data on lifestyle habits and diet in a metabolic epidemiological study of 34 black and 27 white healthy smokers. Results demonstrated that urinary NNAL-Gluc:NNAL ratios, a likely indicator of NNAL glucuronidation and detoxification, were significantly greater in whites than ...
Phosphatidylethanols (PEth) are a group of phospholipids formed only in the presence of ethanol via the action of phospholipase D. Levels of phosphatidylethanols in blood are used as markers of previous alcohol consumption. For this purpose, PEth is more sensitive than carbohydrate deficient transferrin (CDT), urinary ethyl glucuronide (EtG) and ethyl sulfate (EtS). Intake of less than 48 g ethanol/day for three weeks gives a whole blood a PEth concentration of ...
It is a typical apply inside the cosmetics enterprise, especially referring to the foremost producers, to keep costs down by using solely primarily essentially the most cost environment friendly substances doable. That is the method that these corporations assure their products have the very best doable revenue margin. This comply with could also be helpful to them, but it is detrimental to their prospects. What is a EtG alcohol testing ? An EtG, or ethyl glucuronide test could also be preformed through various means; two particularly are urine alcohol testing and hair alcohol testing. An EtG check out detected through urine samples, or with scalp hair samples, test the presence of EtG within the type of a biomarker. EtG or Ethyl glucuronide is a metabolite only produced when alcohol is within the bloodstream. The extra alcohol an individual consumes, the higher quantity of EtG markers are current throughout the hair or urine sample. There are several variations between hair and urine ...
What are Annulment Varieties ? Whats a EtG alcohol testing ? An EtG, or ethyl glucuronide verify will be preformed by way of numerous means; two particularly are urine alcohol testing and hair alcohol testing. An EtG examine detected by way of urine samples, or with scalp hair samples, check the presence of EtG within the kind of a biomarker. EtG or Ethyl glucuronide is a metabolite only produced when alcohol is within the bloodstream. The extra alcohol a person consumes, the higher quantity of EtG markers are current in the hair or urine pattern. There are a variety of variations between hair and urine samples. For a very long time I have been involved about why at the moments career-minded women are smart about work but not love. I didnt have a full sufficient reply, and when something nags at me, I do analysis. So, for five years, I studied more than 1,200 girls from everywhere in the world. My findings led to 2 research-based, self-help books: Good Relationships, printed by New Horizon ...
Its a typical observe in the cosmetics trade, particularly within the case of the principle manufacturers, to maintain prices down by utilizing solely most likely essentially the most value efficient substances potential. This is the best way by which that these companies guarantee their merchandise have one of the best doable revenue margin. This apply may be useful to them, nonetheless its detrimental to their prospects. Whats a EtG alcohol testing ? An EtG, or ethyl glucuronide examine might be preformed by quite a few means; two specifically are urine alcohol testing and hair alcohol testing. An EtG test detected by the use of urine samples, or with scalp hair samples, test the presence of EtG within the type of a biomarker. EtG or Ethyl glucuronide is a metabolite solely produced when alcohol is within the bloodstream. The extra alcohol a person consumes, the greater amount of EtG markers are present in the hair or urine pattern. There are a number of differences between hair and urine ...
It is a typical observe within the cosmetics commerce, especially in the case of the primary producers, to keep up costs down by using solely probably essentially the most value efficient substances possible. This is the way during which that these corporations guarantee their merchandise have the most effective doable profit margin. This apply could also be useful to them, nonetheless it is detrimental to their clients. Whats a EtG alcohol testing ? An EtG, or ethyl glucuronide test might be preformed by numerous means; two particularly are urine alcohol testing and hair alcohol testing. An EtG check detected by means of urine samples, or with scalp hair samples, take a look at the presence of EtG within the form of a biomarker. EtG or Ethyl glucuronide is a metabolite only produced when alcohol is in the bloodstream. The more alcohol a person consumes, the larger amount of EtG markers are present within the hair or urine pattern. There are a number of differences between hair and urine ...
Oily pores and skin comes with a great deal of additional issues akin to melting make-up, greasiness of the face and pimples inflammations and breakouts. Its a typical observe inside the cosmetics commerce, significantly in the case of crucial producers, to keep costs down by utilizing solely most likely essentially the most worth efficient components attainable. Thats one of the simplest ways that these companies guarantee their products have the very best potential income margin. This observe is also helpful to them, however it is detrimental to their purchasers. Whats a EtG alcohol testing ? An EtG, or ethyl glucuronide take a look at will be preformed by varied means; two notably are urine alcohol testing and hair alcohol testing. An EtG examine detected by the use of urine samples, or with scalp hair samples, verify the presence of EtG inside the type of a biomarker. EtG or Ethyl glucuronide is a metabolite solely produced when alcohol is within the bloodstream. The additional alcohol a ...
Richie, J P et al Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in black and white smokers.. Cancer Epidemiology and Prevention Biomarkers 6.10 (1997): 783-790. Web. 31 July. 2021. ...
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Seidl, et al (2000) did a study to determine whether caffeine and taurine containing energy drinks stimulate cognitive performance and well-being. Seidl, et al (2000) performed a double blinded, placebo controlled study using 10 graduate students. The experimental group ingested a capsule containing caffeine, taurine, glucuronolactone, and the placebo group received a control capsule. The measurements were taken at night, prior to and starting one hour after consumption of energy drink ingredients or placebo. The results showed motor reaction times were significantly longer compared to the baseline measurements for the placebo group but remained unchanged in the energy drink group. Additionally, the evaluated feelings for well being, total scores, vitality scores and social extrovertedness scores were again unchanged for the energy drink group but significantly decreased for the placebo group. The researchers concluded the caffeine, taurine, and glucuronolactone had positive effects on human ...
0. Pages in category English words prefixed with deci- The following 19 pages are in this category, out of 19 total. A prefix is a syllable at the beginning of a word. Learn. The dictionary search results are shown in groups of ten. Quick Summary. A vocabulary list featuring Power Prefix: pre-. decathlon . Want to beat your Scrabble friends no matter where you are? Terms in this set (7) decade. 2 prefix meaning tenth: decigram, deciliter, decinormal. 0. Here are some common prefixes. Prefix: Grammar from EnchantedLearning.com. English words beginning with the prefix deca-. Flashcards. A prefix is a type of affix which is attached to the start of the root word. un- and dis-These prefixes have two meanings: they can have a negative meaning (as above), but they can also mean the opposite of an action or to reverse an action. decagon. Many of todays English words contain prefixes from Greek or Latin. Here are a few commonly used words which have prefix non. Dictionary ... A prefix that ...
Fire Definition, Prefix, Suffix, Ologies and Isms, Fire Information and Meaning, Fireworks Definition, Prefix, Suffix, Ologies and Isms, Fireworks Information and Meaning, Fish Definition, Prefix, Suffix, Ologies and Isms, Fish Information and Meaning, Flags Definition, Prefix, Suffix, Ologies and Isms, Flags Information and Meaning, Flesh Definition, Prefix, Suffix, Ologies and Isms, Flesh Information and Meaning, Flowers Definition, Prefix, Suffix, Ologies and Isms, Flowers Information and Meaning, Food and Nutrition Definition, Prefix, Suffix, Ologies and Isms, Food and Nutrition Information and Meaning, Foreigners Definition, Prefix, Suffix, Ologies and Isms, Foreigners Information and Meaning, Form Definition, Prefix, Suffix, Ologies and Isms, Form Information and Meaning, Fossils Definition, Prefix, Suffix, Ologies and Isms, Fossils Information and Meaning, etc…
Dancing Definition, Prefix, Suffix, Ologies and Isms, Dancing Information and Meaning, Dante Definition, Prefix, Suffix, Ologies and Isms, Dante Information and Meaning, Darkness Definition, Prefix, Suffix, Ologies and Isms, Darkness Information and Meaning, Deafness Definition, Prefix, Suffix, Ologies and Isms, Deafness Information and Meaning, Death Definition, Prefix, Suffix, Ologies and Isms, Death Information and Meaning, Decaying Definition, Prefix, Suffix, Ologies and Isms, Decaying Information and Meaning, Demons Definition, Prefix, Suffix, Ologies and Isms, Demons Information and Meaning, Depth Definition, Prefix, Suffix, Ologies and Isms, Depth Information and Meaning, Deserts Definition, Prefix, Suffix, Ologies and Isms, Deserts Information and Meaning, Devil Definition, Prefix, Suffix, Ologies and Isms, Devil Information and Meaning, etc…
Prefixes are combined with base units and derived units to form multiples of SI units. The factors designated by prefixes are powers of 10, and most prefixes involve exponents that are simple multiples of 3, thereby facilitating conversion procedures using successive multiplications by 103 or 10−3. Compound prefixes formed by the combination of 2 or more SI prefixes generally are not used. It is preferable to use an expression with a single prefix. The kilogram is the only SI base unit with a prefix as part of its name and symbol (kg). However, because compound prefixes are not recommended, prefixes
Schmiedeberg and Meyer followed up on early studies of camphor metabolism and isolated a camphor conjugate from the urine of dogs dosed with camphor.6 They isolated and characterized the sugar moiety as glucuronic acid. Schmid had attributed the formation of euxanthic acid as occurring through the vital process. It wasnt until 1953 that this process was elucidated through the discovery of uridine diphosphoglucuronic acid (UDPGA) by Dutton and Storey and their elaboration of the role of the co-factor in glucuronide formation.7 Ref: 1O.L.Erdmann, J.Prakt. Chem., 33:190 (1844); 37:385 (184), 2W. Schmid, Ann. Chem. Pharm., 93:83 (1855), 3A.Baeyer, Ann. Chem. Pharm., 155:257 (1870) 4J.Von Mering and F. Musculus, Ber. Dtsch.Chem. Ges., 8:662 (1875), 5M.Jaffe, Z.Physiol.Chem. 2:47 (1878), 6O.Schmiedeberg and H.Meyer, Z.Physiol.Chem. 3:422 (1879), 7Dutton, G.J.and Storey, I.D.E., Biochem J.53:37 (1953). Pictures: J.Koch-Weser and P.J.Schechter, Life Sciences 22:1361-1372 (1978). ...
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A vocabulary list featuring Power Prefix: uni-. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Also explore over 28 similar quizzes in this category. The following 200 pages are in this category, out of 2,401 total. Nucleotide Accession Prefixes Prefix Database Type; BA,DF,DG,LD: DDBJ: Clear the board by removing sets of 3. There are cases where these assignments are not adhered to. : die Primer; IPA: [ˊpʁaɪ̯mɐ]) wird in der Molekularbiologie ein Oligonukleotid bezeichnet, das als Startpunkt für DNA-replizierende Enzyme wie die DNA-Polymerase dient.. DNA-Polymerasen benötigen eine Hydroxygruppe als Startpunkt für ihre erste Verknüpfungsreaktion. A prefix is affix thats added in front of a word and often changes the meaning of it. Information about various common prefixes and suffixes, including meanings and examples. How to use prim in a sentence. An example would be im-, this can mean not or into. What does prim and proper expression mean? Meaning ...
Learn about Neutrexin (Trimetrexate Glucuronate Inj) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Prefixes and Suffixes. A prefix is a word part added to the beginning of a root word. A prefix changes the meaning of a word. A suffix is a word part added to the end of a root word. A suffix also changes the meaning of a word. Prefixes We Know. Examples. im- not in- not Slideshow 736122 by ciqala
HPLC-MS/MS Method Validation, determination process for study purpose and others uses also and Glucuronides products check in our vivan life science site.
Propranolol glucuronide is intended for Pharmaceuticals, Doping agents applications. All information about Propranolol glucuronide sodium salt is provided in the MSDS. We deliver compounds with high purity levels and a comprehensive Certificate of Analysis. Connect to your member account to consult the documents ...
We need to define how prefixes interact with contractions. I propose that mappings with prefixes have precedence, and that prefixes should be matched first. This is to keep them reasonably implementable: When we have a mapping with both a prefix and a contraction suffix (like in Japanese: ぐ,ゞ), then the matching needs to go in both directions. The contraction might involve discontiguous matching which needs complex text iteration and handling of skipped combining marks (or rewriting of the text, as in the UCA). Prefix matching should be first because it is contiguous and therefore simple. Once the prefix is matched, we can return to the original text index (right after the prefix) and look at all of the contractions for the prefix ...
Mouse Monoclonal Anti-beta-1,3-Glucuronyltransferase 1/B3GAT1 Antibody (HCD57). Validated: Flow. Tested Reactivity: Human. 100% Guaranteed.
PREFIX def-bw: ,http://environment.data.gov.uk/def/bathing-water/, PREFIX def-bwq: ,http://environment.data.gov.uk/def/bathing-water-quality/, PREFIX def-ef: ,http://location.data.gov.uk/def/ef/SamplingPoint/, PREFIX rdf: ,http://www.w3.org/1999/02/22-rdf-syntax-ns#, PREFIX rdfs: ,http://www.w3.org/2000/01/rdf-schema#, PREFIX skos: ,http://www.w3.org/2004/02/skos/core#, PREFIX time: ,http://www.w3.org/2006/time#, CONSTRUCT {?item def-bwq:faecalColiformCount ?___4 . ?item def-bwq:abnormalWeatherException ?___5 . ?item rdf:type ?___6 . ?item def-bwq:samplingPoint ?___7 . ?___7 def-ef:samplePointNotation ?___8 . ?item def-bwq:entrovirusQualifier ?___9 . ?___9 def-bwq:countQualifierNotation ?___10 . ?item def-bwq:sampleClassification ?___11 . ?___11 def-bwq:complianceCodeNotation ?___12 . ?item def-bwq:discountable ?___13 . ?item def-bwq:intestinalEnterococciQualifier ?___14 . ?___14 def-bwq:countQualifierNotation ?___15 . ?item def-bwq:bathingWater ?___16 . ?___16 skos:prefLabel ?___17 . ?item ...
What is the difference between Affix Prefix and Suffix? Prefix can be used at the beginning of a word. Suffix can be used at the end of a word. Affix can..
PREFIX def-bw: ,http://environment.data.gov.uk/def/bathing-water/, PREFIX def-bwq: ,http://environment.data.gov.uk/def/bathing-water-quality/, PREFIX def-ef: ,http://location.data.gov.uk/def/ef/SamplingPoint/, PREFIX rdfs: ,http://www.w3.org/2000/01/rdf-schema#, PREFIX skos: ,http://www.w3.org/2004/02/skos/core#, PREFIX time: ,http://www.w3.org/2006/time#, CONSTRUCT {?item def-bwq:discountable ?___4 . ?item def-bwq:faecalColiformCount ?___5 . ?item def-bwq:faecalStreptococciCount ?___6 . ?item def-bwq:totalColiformQualifier ?___7 . ?___7 def-bwq:countQualifierNotation ?___8 . ?item def-bwq:intestinalEnterococciCount ?___9 . ?item def-bwq:sampleClassification ?___10 . ?___10 def-bwq:complianceCodeNotation ?___11 . ?item def-bwq:faecalStreptococciQualifier ?___12 . ?___12 def-bwq:countQualifierNotation ?___13 . ?item def-bwq:escherichiaColiCount ?___14 . ?item def-bwq:discounted ?___15 . ?item def-bwq:samplingPoint ?___16 . ?___16 def-ef:samplePointNotation ?___17 . ?item def-bwq:sampleWeek ?___18 ...
Biology prefixes and suffixes help us to understand biology terms. The prefix (chrom- or chromo-) means color. A chromoplast is a pigmented plant cell.
Biology prefixes and suffixes help us to understand science terms. The prefix auto- means self, same, or refers to an involuntary process.
Ark monitors collect data by sending scamper probes continuously to destination IP addresses. Destinations are selected randomly from each routed IPv4 /24 prefix on the Internet such that a random address in each prefix is probed approximately every 48 hours (one probing cycle). A single monitor wont probe all prefixes, but the prefixes it does probe will be randomly distributed, which gives a good sample cross section of the address space. As each probe travels from the monitor to its final destination, it passes through several IP addresses (ie, routers) which are owned by different autonomous systems (ASes ...
Can you name the Surgical Suffixes, Prefixes, and Terms Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by awheeler9
File lib/rss/rss.rb, line 823 def install_ns(prefix, uri) if self::NSPOOL.has_key?(prefix) raise OverlappedPrefixError.new(prefix) end self::NSPOOL[prefix] = uri end ...
SCI, SSCI ve AHCI dışındaki indeks ve özler tarafından taranan dergilerde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden yayınlar dışındaki makale ...
Complaint forms are available at http://www.hhs.gov/ocr/office/file/index.html. LANGUAGE ASSISTANCE SERVICES are available to you at Arizona Digestive Health free of charge. To obtain services, call 602-264-9100.. Español (Spanish): ATENCIÓN: si habla español, tiene a su disposición servicios gratuitos de asistencia lingüística. Llame al 602-264-9100.. 繁體中文 (Chinese): 注意:如果您使用繁體中文,您可以免費獲得語言援助服務。請致電 602-264-9100.. Tiếng Việt (Vietnamese): CHÚ Ý: Nếu bạn nói Tiếng Việt, có các dịch vụ hỗ trợ ngôn ngữ miễn phí dành cho bạn. Gọi số 602-264-9100.. العربية (Arabic): ملحوظة: إذا كنت تتحدث اذكر اللغة، فإن خدمات المساعدة اللغوية تتوافر لك بالمجان. اتصل برقم 602-264-9100.. Tagalog (Tagalog - Filipino): PAUNAWA: Kung nagsasalita ka ng Tagalog, maaari kang gumamit ng mga serbisyo ng tulong sa wika nang walang bayad. ...
1999) A Guideline for the District Health Management Team (DHMT) on Counselling Services. National AIDS Control Programme. ISBN 9987-650-06-6 (1999) Guidelines for Home Based Care Services in Tanzania. National AIDS Control Programme. ISBN 9987-650-02-3 (1999) Manual for Trainers of Hospital Based Counsellors. National AIDS Control Programme. ISBN -9987-650-11-2 ...
UDP-glucuronate decarboxylase (UGD; EC 4.1.1.35) catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is then ... 2002). "UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization". J ... "Entrez Gene: UXS1 UDP-glucuronate decarboxylase 1". CS1 maint: discouraged parameter (link) Maruyama K, Sugano S (1994). "Oligo ...
This enzyme participates in pentose and glucuronate interconversions. BURMA DP, HORECKER BL (1958). "Pentose fermentation by ...
This enzyme participates in pentose and glucuronate interconversions. As of late 2007, only one structure has been solved for ...
This enzyme participates in pentose and glucuronate interconversions. As of late 2007, two structures have been solved for this ...
This enzyme participates in pentose and glucuronate interconversions. Dahms AS, Donald A (1982). "D-xylo-Aldonate dehydratase ...
This enzyme participates in pentose and glucuronate interconversions. Shaw DR (February 1962). "Pyrophosphorolysis and enzymic ...
This enzyme participates in pentose and glucuronate interconversions. Chiang C, Knight SG (1960). "A new pathway of pentose ...
This enzyme participates in pentose and glucuronate interconversions. Hickman J, Ashwell G (1960). "Uronic acid metabolism in ...
Mechanism of action of UDP-glucuronate carboxyl-lyase. Biosynthesis of uridine diphosphate-D-xylose. V. UDP-D-glucuronate and ... V. UDP-D-glucuronate and UDP-D-galacturonate carboxy-lyase of Ampullariella digitata. Fan, D. F. and Feingold, D. S. Arch. ... Mechanism of action of UDP-glucuronate carboxyl-lyase. Schutzbach, J. S. and Feingold D. S. J. Biol. Chem. 245:2476-2482, 1970 ...
This enzyme participates in pentose and glucuronate interconversions. This enzyme catalyses the conversion of L-arabinose to L- ...
This enzyme participates in pentose and glucuronate interconversions. Glaser L (April 1963). "Ribitol-5-phosphate dehydrogenase ...
This enzyme participates in pentose and glucuronate interconversions. As of late 2007, only one structure has been solved for ...
This enzyme participates in pentose and glucuronate interconversions. Moran F, Nasuno S, Starr MP (1968). "Oligogalacturonide ... 2 5-dehydro-4-deoxy-D-glucuronate Hence, this enzyme has one substrate, 4-(4-deoxy-beta-D-gluc-4-enuronosyl)-D-galacturonate, ... and one product, 5-dehydro-4-deoxy-D-glucuronate. This enzyme belongs to the family of lyases, specifically those carbon-oxygen ...
This enzyme participates in pentose and glucuronate interconversions. Wing RA, Yamaguchi J, Larabell SK, Ursin VM, McCormick S ...
This enzyme participates in pentose and glucuronate interconversions. As of late 2007, two structures have been solved for this ...
This enzyme participates in pentose and glucuronate interconversions. This enzyme belongs to the family of oxidoreductases, ...
This enzyme participates in pentose and glucuronate interconversions. As of late 2007, only one structure has been solved for ...
This enzyme participates in pentose and glucuronate interconversions. Yamanaka K, Gino M, Kaneda R (1977). "A specific NAD-D- ...
This enzyme participates in pentose and glucuronate interconversions. Buchert J, Viikari L (1988). "The role of xylonolactone ...
This enzyme participates in pentose and glucuronate interconversions. SMILEY JD, ASHWELL G (1960). "Uronic acid metabolism in ...
This enzyme participates in pentose and glucuronate interconversions. This enzyme belongs to the family of oxidoreductases, ...
This enzyme participates in pentose and glucuronate interconversions. As of late 2007, 3 structures have been solved for this ...
This enzyme participates in pentose and glucuronate interconversions. Dahms AS (1974). "3-Deoxy-D-pentulosonic acid aldolase ...
This enzyme is also called D-ribulokinase (phosphorylating). This enzyme participates in pentose and glucuronate ...
This enzyme participates in pentose and glucuronate interconversions. As of late 2007, only one structure has been solved for ...
This enzyme participates in pentose and glucuronate interconversions. Chiang C, Knight SG (1961). "L-Arabinose metabolism by ...
This enzyme participates in pentose and glucuronate interconversions. Smiley JD, Ashwell G (1961). "Purification and properties ...
The main metabolite formed is 4-hydroxyatomoxetine, which glucuronate rapidly. 4-hydroxyatomoxetine is equivalent to ...
Miglio, F.; Rovati, L. C.; Santoro, A.; Setnikar, I. (August 2000). "Efficacy and safety of oral betaine glucuronate in non- ...
... chondroitin-glucuronate C5-epimerase is identical to SART2". J Biol Chem. 281 (17): 11560-8. doi:10.1074/jbc.M513373200. PMID ... chondroitin-glucuronate C5-epimerase is identical to SART2". J. Biol. Chem. 281 (17): 11560-8. doi:10.1074/jbc.M513373200. PMID ...
In enzymology, a glucuronate isomerase (EC 5.3.1.12) is an enzyme that catalyzes the chemical reaction D-glucuronate ⇌ {\ ... and D-glucuronate ketol-isomerase. This enzyme participates in pentose and glucuronate interconversions. As of late 2007, two ... The systematic name of this enzyme class is D-glucuronate aldose-ketose-isomerase. Other names in common use include uronic ... displaystyle \rightleftharpoons } D-fructuronate Hence, this enzyme has one substrate, D-glucuronate, and one product, D- ...
D-glucuronate dehydrogenase, D-glucuronate reductase, and L-glucuronate reductase (incorrect). This enzyme participates in ... In enzymology, a glucuronate reductase (EC 1.1.1.19) is an enzyme that catalyzes the chemical reaction L-gulonate + NADP+ ⇌ {\ ... displaystyle \rightleftharpoons } D-glucuronate + NADPH + H+ Thus, the two substrates of this enzyme are L-gulonate and NADP+, ... whereas its 3 products are D-glucuronate, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically ...
Trimetrexate Glucuronate Inj) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, ... Trimetrexate glucuronate for injection is a pale greenish-yellow powder or cake. Trimetrexate glucuronate is soluble in water ... TABLE 2: TREATMENT IND Survival Rate One Month After Completion of Neutrexin (trimetrexate glucuronate inj) Therapy. IST RIST. ... Neutrexin (trimetrexate glucuronate inj) forms a precipitate instantly upon contact with chloride ion or leucovorin, therefore ...
Pentose and glucuronate interconversions - Veillonella parvula [ Pathway menu , Organism menu , Pathway entry , Download KGML ...
Pentose and glucuronate interconversions - Roseobacter denitrificans [ Pathway menu , Organism menu , Pathway entry , Download ...
D-glucuronate. + NADPH. + H+. Synonyms. AKR1A1, aldehyde reductase, aldehyde reductase II, ALR1, D-glucuronate dehydrogenase, D ... 1.1.1.19: glucuronate reductase. This is an abbreviated version, for detailed information about glucuronate reductase, go to ... glucuronate reductase, D-glucuronic reductase, hexonate dehydrogenase, L-glucuronate reductase, L-gulonate NAD-3-oxidoreductase ... Source Tissue on EC 1.1.1.19 - glucuronate reductase. Please wait a moment until all data is loaded. This message will ...
UDP glucuronate decarboxylase and synthesis of capsular polysaccharide in Cryptococcus neoformans. Jacobson, E.S., Payne, W.R. ... UDP glucuronate decarboxylase and synthesis of capsular polysaccharide in Cryptococcus neoformans [4]. ...
UDP Glucuronate Decarboxylase and Synthesis of Capsular Polysaccharide in Cryptococcus neoformans. Eric S. Jacobson, William R. ... UDP Glucuronate Decarboxylase and Synthesis of Capsular Polysaccharide in Cryptococcus neoformans. Eric S. Jacobson, William R. ... UDP Glucuronate Decarboxylase and Synthesis of Capsular Polysaccharide in Cryptococcus neoformans. Eric S. Jacobson, William R ... UDP Glucuronate Decarboxylase and Synthesis of Capsular Polysaccharide in Cryptococcus neoformans Message Subject (Your Name) ...
Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila. T.E. Haerry, T.R. Heslip, J.L. Marsh, M.B. ... Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila. T.E. Haerry, T.R. Heslip, J.L. Marsh, M.B. ... Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila. T.E. Haerry, T.R. Heslip, J.L. Marsh, M.B. ... Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila Message Subject (Your Name) has sent you a message ...
Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro ...
Methotrexate, Trimetrexate Glucuronate, and Leucovorin in Treating Patients With Refractory or Recurrent Osteosarcoma. The ... Drug Information available for: Leucovorin Methotrexate Trimetrexate glucuronate Genetic and Rare Diseases Information Center ... Patients receive high-dose methotrexate IV over 4 hours on days 1 and 8 and oral trimetrexate glucuronate twice daily on days 2 ... PURPOSE: This phase I trial is studying the side effects and best dose of trimetrexate glucuronate when given together with ...
Transport of Glutathione, Glucuronate, and Sulfate Conjugates by the MRP Gene-encoded Conjugate Export Pump. Gabriele ... Transport of Glutathione, Glucuronate, and Sulfate Conjugates by the MRP Gene-encoded Conjugate Export Pump ... Transport of Glutathione, Glucuronate, and Sulfate Conjugates by the MRP Gene-encoded Conjugate Export Pump ... Transport of Glutathione, Glucuronate, and Sulfate Conjugates by the MRP Gene-encoded Conjugate Export Pump ...
Drug Information available for: Leucovorin calcium Trimetrexate glucuronate Genetic and Rare Diseases Information Center ... To provide trimetrexate glucuronate to immunosuppressed patients with Pneumocystis carinii pneumonia (PCP) for whom this ... A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate With Leucovorin Protection for Patients With ... A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate With Leucovorin Protection for Patients With ...
Drug Information available for: Leucovorin calcium Trimetrexate glucuronate Genetic and Rare Diseases Information Center ... To provide trimetrexate glucuronate to immunosuppressed patients with Pneumocystis carinii pneumonia (PCP) for whom this ... A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate With Leucovorin Protection for Patients With ... Patients receive intravenous infusions of trimetrexate glucuronate and leucovorin for 21 days. Leucovorin is continued for 3 ...
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Trimetrexate glucuronate [USAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information ... Substance Name: Trimetrexate glucuronate [USAN]. RN: 82952-64-5. UNII: L137U4A79K. InChIKey: ZCJXQWYMBJYJNB-LRDBBFHQSA-N. Notes ... 2,4-Diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline mono-D-glucuronate ... 2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-, mono-D-glucuronate ...
... pentose and glucuronate interconversion. This protein is involved in the pathway pentose and glucuronate interconversion, which ... D-glucuronate = D-fructuronate.UniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB ... Glucuronate isomeraseUniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ... View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in ...
Myo-inositol + O2 = D-glucuronate + H2O.1 Publication. ,p>Manually curated information for which there is published ... This protein is involved in step 1 of the subpathway that synthesizes D-glucuronate from myo-inositol.. Proteins known to be ... View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glucuronate from myo- ... This subpathway is part of the pathway myo-inositol degradation into D-glucuronate, which is itself part of Polyol metabolism. ...
UDP-Glucuronate Decarboxylase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... UDP-D-glucuronate = UDP-D-xylose + CO(2). *UXS1_HUMAN,Q8NBZ7. UniProtKB/Swiss-Prot Function: Catalyzes the NAD-dependent ... UXS1 (UDP-Glucuronate Decarboxylase 1) is a Protein Coding gene. Among its related pathways are Amino sugar and nucleotide ... Pathway: Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step ...
13- Pentose phosphate pathway; fructose-, mannose metabolism; pentose and glucuronate interconversions; peptidoglycan- and ...
Glucuronates / metabolism * Glucuronosyltransferase / biosynthesis * Glucuronosyltransferase / genetics* * ...
Glucuronates / metabolism * Glucuronidase / chemistry * Glucuronidase / metabolism * Glucuronidase / physiology* * Humans * ...
4) urea; 5) fructose; 6) glucose; 7) honey; 8) lactic acid; 9) maltose; 10) sodium glucuronate; and 11) mixtures thereof, with ...
This assay can also be used to determine the concentration of beta-glucuronides and glucuronate 1-phosphate after enzymatic ... Reference : A spectrophotometric assay of D-glucuronate based on Escherichia coli uronate isomera.... ... A spectrophotometric assay of D-glucuronate based on Escherichia coli uronate isomerase and mannonate dehydrogenase. ... in which D-glucuronate is converted to D-mannonate with concomitant oxidation of NADH to NAD(+). The sensitivity of this assay ...
Glucuronate pathway (uronate pathway) Glucuronate pathway (uronate pathway)Pathway module; Carbohydrate and lipid metabolism; ...
2 B and C ). Glucuronate, mannose, fucose (Fig. 2D ), and ribose were involved in maintenance, but not initiation. The order of ... Glucuronate, mannose, fucose, and ribose appeared to be involved in maintenance, but not initiation. The in vitro order of ... glucuronate released from oligosaccharides by β-glucuronidase (ΔuidA), tryptophan (ΔtnaA), and gluconeogenic nutrients (ΔppsA Δ ... glucuronate , mannose , fucose , ribose. The results of this systematic analysis of nutrients used by E. coli MG1655 to ...
d-glucuronate 5-P. 2.8. Imidodiphosphate. 29.5. Pyrophosphate. 2.8. d-3-deoxyglucose 6-P. 29.0. Thymidine 5′-triphosphate. 2.8 ...
... trimetrexate glucuronate; triptorelin; tubulozole hydrochloride; uracil mustard; uredepa; vapreotide; verteporfin; vinblastine ...
... trimetrexate glucuronate; triptorelin; tubulozole hydrochloride; uracil mustard; uredepa; vapreotide; verteporfin; vinblastine ...
  • UDP glucuronate decarboxylase activity was comparable in encapsulated and non-encapsulated strains of Cryptococcus neoformans , required NAD ( K a = 0.2 mM), and was inhibited by NADH ( K i = 0.1 mM) and UDP xylose. (asm.org)
  • UXS1 (UDP-Glucuronate Decarboxylase 1) is a Protein Coding gene. (genecards.org)
  • 33 UDP-Glucuronate Decarboxylase 1 (UXS1) Antikörper von 7 Herstellern verfügbar auf www.antikoerper-online.de. (antikoerper-online.de)
  • This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism. (uniprot.org)
  • View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism . (uniprot.org)
  • This subpathway is part of the pathway myo-inositol degradation into D-glucuronate, which is itself part of Polyol metabolism. (uniprot.org)
  • View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glucuronate from myo-inositol , the pathway myo-inositol degradation into D-glucuronate and in Polyol metabolism . (uniprot.org)
  • In addition, the finding indicates that the catabolic D-glucuronate pathway in A. niger differs fundamentally from the other known D-glucuronate pathways. (vtt.fi)
  • d-Glucuronate is a key metabolite in the process of detoxification of xenobiotics and in a recently constructed synthetic pathway to produce d-glucaric acid, a "top value-added chemical" from biomass. (mit.edu)
  • D-xylulose is a monosaccharide, converted from xylitol in the glucuronate pathway. (sigmaaldrich.com)
  • This enzyme participates in pentose and glucuronate interconversions. (wikipedia.org)
  • Pentose and glucuronate interconversions 4 of 311 pathways' ## [1] 'Querying. (bioconductor.org)
  • Trimetrexate glucuronate for injection is a pale greenish-yellow powder or cake. (rxlist.com)
  • Neutrexin (trimetrexate glucuronate for injection) with concurrent leucovorin administration (leucovorin protection) is indicated as an alternative therapy for the treatment of moderate-to-severe Pneumocystis carinii pneumonia ( PCP ) in immunocompromised patients, including patients with the acquired immunodeficiency syndrome (AIDS), who are intolerant of, or are refractory to, trimethoprim-sulfamethoxazole therapy or for whom trimethoprim-sulfamethoxazole is contraindicated. (rxlist.com)
  • Neutrexin (trimetrexate glucuronate for injection) is administered at a dose of 45 mg/m 2 once daily by intravenous infusion over 60 minutes. (drugs.com)
  • Hematologic toxicity: Neutrexin (trimetrexate glucuronate for injection) and leucovorin doses should be modified based on the worst hematologic toxicity according to the following table. (drugs.com)
  • Neutrexin (trimetrexate glucuronate for injection) [MedImmune Oncology, Inc. (bioportfolio.com)
  • In enzymology, a glucuronate isomerase (EC 5.3.1.12) is an enzyme that catalyzes the chemical reaction D-glucuronate ⇌ {\displaystyle \rightleftharpoons } D-fructuronate Hence, this enzyme has one substrate, D-glucuronate, and one product, D-fructuronate. (wikipedia.org)
  • The systematic name of this enzyme class is D-glucuronate aldose-ketose-isomerase. (wikipedia.org)
  • Other names in common use include uronic isomerase, uronate isomerase, D-glucuronate isomerase, uronic acid isomerase, and D-glucuronate ketol-isomerase. (wikipedia.org)
  • en] Escherichia coli uronate isomerase and mannonate dehydrogenase were overexpressed in E. coli BL21(DE3)pLysS cells and purified to near-homogeneity. (uni.lu)
  • The KduI/IolB family of enzymes includes 5-keto 4-deoxyuronate isomerase (KduI) and 5-deoxy-glucuronate isomerase (IolB). (ebi.ac.uk)
  • 2.2 Angstrom Crystal Structure of Glucuronate Isomerase from Salmonella typhimurium. (csgid.org)
  • Neutrexin is the brand name for trimetrexate glucuronate. (rxlist.com)
  • Neutrexin (trimetrexate glucuronate inj) is available as a sterile lyophilized powder, containing trimetrexate glucuronate equivalent to either 200mg or 25mg of trimetrexate without any preservatives or excipients. (rxlist.com)
  • What are the precautions when taking trimetrexate glucuronate inj (Neutrexin)? (rxlist.com)
  • This indication is based on the results of a randomized , controlled double-blind trial comparing Neutrexin (trimetrexate glucuronate inj) with concurrent leucovorin protection (TMTX/LV) to trimethoprim-sulfamethoxazole (TMP/SMX) in patients with moderate-to-severe Pneumocystis carinii pneumonia, as well as results of a Treatment IND. (rxlist.com)
  • The FDA granted a Treatment IND for Neutrexin (trimetrexate glucuronate inj) with leucovorin protection in February 1988 to make Neutrexin (trimetrexate glucuronate inj) therapy available to HIV-infected patients with histologically confirmed PCP who had disease refractory to or who were intolerant of TMP/SMX and/or intravenous pentamidine. (rxlist.com)
  • In Canada, Hexalen (altretamine) was approved in August 1994 for use as a first-line and salvage treatment for ovarian cancer, while NeuTrexin (trimetrexate glucuronate) was approved in December 1993 for the treatment of Pneumocystis carinii pneumonia (PCP), the most common life-threatening infection associated with AIDS. (thefreedictionary.com)
  • Reference : A spectrophotometric assay of D-glucuronate based on Escherichia coli uronate isomera. (uni.lu)
  • Other names in common use include aldehyde reductase, L-hexonate:NADP dehydrogenase, TPN-L-gulonate dehydrogenase, aldehyde reductase II, NADP-L-gulonate dehydrogenase, D-glucuronate dehydrogenase, D-glucuronate reductase, and L-glucuronate reductase (incorrect). (wikipedia.org)
  • Uridinediphosphoglucose (UDPG) dehydrogenase, UDPG epimerase and UDP-glucuronate epimerase activities in H. diminuta were highest in subtegumental parenchyma, indicating that this is where mucopolysaccharide precursors are synthesized. (eurekamag.com)
  • In enzymology, a glucuronate reductase (EC 1.1.1.19) is an enzyme that catalyzes the chemical reaction L-gulonate + NADP+ ⇌ {\displaystyle \rightleftharpoons } D-glucuronate + NADPH + H+ Thus, the two substrates of this enzyme are L-gulonate and NADP+, whereas its 3 products are D-glucuronate, NADPH, and H+. (wikipedia.org)
  • This is an abbreviated version, for detailed information about glucuronate reductase, go to the full flat file . (brenda-enzymes.org)
  • A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate With Leucovorin Protection for Patients With Pneumocystis Carinii Pneumonia. (clinicaltrials.gov)
  • For the catabolism of D-glucuronate, different pathways are used by different life forms. (vtt.fi)
  • 2) Chondroitin sulfate(D-glucuronate GalNAc sulfate)It is the most abundant GAG. (powershow.com)
  • UDP-glucose + 2 NAD + + H 2 O = UDP-glucuronate + 2 NADH. (rcsb.org)
  • Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. (hindawi.com)
  • This protein is involved in step 1 of the subpathway that synthesizes D-glucuronate from myo-inositol. (uniprot.org)
  • To provide trimetrexate glucuronate to immunosuppressed patients with Pneumocystis carinii pneumonia (PCP) for whom this investigational compound could provide significant medical benefit. (clinicaltrials.gov)
  • The deletion of the corresponding gene, the gluC, results in a phenotype of no growth on D-glucuronate. (vtt.fi)
  • In this communication, we describe an enzyme that is essential for D-glucuronate catabolism in the filamentous fungus Aspergillus niger. (vtt.fi)
  • This assay can also be used to determine the concentration of beta-glucuronides and glucuronate 1-phosphate after enzymatic hydrolysis of these compounds with beta-glucuronidase or alkaline phosphatase. (uni.lu)
  • The fourth ingredient Sodium Glucuronate aids the elimination of various compounds by making them more easily eliminated through urination. (professionalmuscle.com)
  • Although this may seem a bit out of place I believe it is very much worth our while to examine before looking at the specific actions of Sodium Glucuronate. (professionalmuscle.com)
  • Cohorts of 3-6 patients receive escalating doses of trimetrexate glucuronate until the maximum tolerated dose (MTD) is determined. (clinicaltrials.gov)
  • Rabbits excrete it mainly as glucuronate (12-55 per cent. (inchem.org)
  • Determine the maximum tolerated dose of trimetrexate glucuronate when administered with high-dose methotrexate and leucovorin calcium in patients with refractory or recurrent high-grade osteosarcoma. (clinicaltrials.gov)
  • Patients receive high-dose methotrexate IV over 4 hours on days 1 and 8 and oral trimetrexate glucuronate twice daily on days 2-6 and 9-13. (clinicaltrials.gov)
  • PURPOSE: This phase I trial is studying the side effects and best dose of trimetrexate glucuronate when given together with methotrexate and leucovorin in treating patients with refractory or recurrent osteosarcoma. (clinicaltrials.gov)
  • Patients receive intravenous infusions of trimetrexate glucuronate and leucovorin for 21 days. (clinicaltrials.gov)
  • UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1. (abcam.com)
  • Leucovorin is continued for 3 additional days after discontinuation of trimetrexate glucuronate. (clinicaltrials.gov)
  • In animals, d -Glc is converted to AsA via d -glucuronate, l -gulonate, and l -gulono-1,4-lactone ( l -GulL), which is then oxidized to AsA. (plantphysiol.org)